PMC9136431_01
Histological findings of the liver.. The liver biopsy showed marked canalicular cholestasis, predominantly in a pericentral
(zone 3) distribution. Numerous large intracanalicular bile thrombi were present
throughout the hepatic parenchyma, associated with hepatocyte rosettes and patchy
cytoplasmic condensation and eosinophilia. Lobular inflammation, as is the norm in
cholestatic hepatitis, was minimal within the lobule. The portal tracts showed only
minimal inflammation, without any evidence of bile duct injury or loss, and there was no
interface hepatitis present (x200).
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PMC9136431_01_10.1177_20420986221100118-fig1.jpg
fig1-20420986221100118
Histological findings of a liver biopsy (Figure 1) showed marked canalicular cholestasis (predominantly in a pericentral (Zone 3) distribution) associated with numerous large intracanalicular bile thrombi throughout the parenchyma.
Changes in biochemical examination findings.
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PMC9136431_01_10.1177_20420986221100118-fig2.jpg
fig2-20420986221100118
The cholestasis improved 10 weeks after the discontinuation of CT-P13, and no DILI redeveloped, even after re-switching from CT-P13 to O-IFX (Figure 2).