PMC3687442_01
This histological feature reveals that the normal prostatic tissues have been replaced by diffusely infiltrated large lymphoid cells. H&E x400
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F0001
Histological examination of the tumor revealed that the normal prostatic tissues were diffusely infiltrated by large lymphoid cells, with vesicular nuclei, fine chromatin and scanty cytoplasm, either amphophilic or basophilic (Fig. 1).
Immunohistochemistry showed the tumor cells to be positive for CD45, CD20, CD79a. DAB x400
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F0002
Immunohistochemically, the tumor cells were strongly positive for CD45, CD20, CD79a and negative for CD10, CD5, CD23, CD3, CD45RO, PSA, P504S, 34betaE12, CKpan, Syn and CgA (Fig. 2).
PMC3687442_02
The tumor was composed of large atypical cells with vesicular nuclei and abundant cytoplasm, H&E x400
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F0003
It had a diffuse infiltrating pattern (Fig. 3).
Immunohistochemistry showed that the tumor cells were positive for CD45, CD20, CD79a, DAB x400
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F0004
PSA, P504S, 34betaE12, CKpan, Syn and CgA were negative (Fig. 4). Pathologic examination confirmed the diagnosis of primary NHL (diffuse large B-cell type) of the prostate.