PMC2989757_01
Metastatic malignant mesothelioma to lymph node. (H&E, 10x). The inset shows that the tumor cells are polygonal with well-defined cell membranes and dense eosinophilic cytoplasm (H&E, 60x).
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fig1
Nuclei were generally single, and mitoses were scant (Figure 1).
Metastatic malignant mesothelioma to lymph node. The tumor cells are positive for cytokeratin by immunohistochemistry (Keratin, 40x).
PRI2010-846571.002.jpg
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fig2
Tumor cells were positive for cytokeratin (Figure 2), calretinin (Figure 3), D2-40 (Figure 4), CD10, and CK5/6, focally positive for CK7 and CA-125, and negative for hepatocellular antigen, renal carcinoma antigen, prostatic specific antigen, carcinoembryonic antigen, HMB45, S100 protein, p63, CDX2, CK20, thyroid transcription factor-1, inhibin, and alpha-feto protein by immunohistochemistry.
Metastatic malignant mesothelioma to lymph node. The tumor cells are positive for calretinin by immunohistochemistry (Calretinin, 40x).
PRI2010-846571.003.jpg
PMC2989757_01_PRI2010-846571.003.jpg
fig3
Tumor cells were positive for cytokeratin (Figure 2), calretinin (Figure 3), D2-40 (Figure 4), CD10, and CK5/6, focally positive for CK7 and CA-125, and negative for hepatocellular antigen, renal carcinoma antigen, prostatic specific antigen, carcinoembryonic antigen, HMB45, S100 protein, p63, CDX2, CK20, thyroid transcription factor-1, inhibin, and alpha-feto protein by immunohistochemistry.
Metastatic malignant mesothelioma to lymph node. The tumor cells are positive for D2-40 by immunohistochemistry (D2-40, 40x).
PRI2010-846571.004.jpg
PMC2989757_01_PRI2010-846571.004.jpg
fig4
Tumor cells were positive for cytokeratin (Figure 2), calretinin (Figure 3), D2-40 (Figure 4), CD10, and CK5/6, focally positive for CK7 and CA-125, and negative for hepatocellular antigen, renal carcinoma antigen, prostatic specific antigen, carcinoembryonic antigen, HMB45, S100 protein, p63, CDX2, CK20, thyroid transcription factor-1, inhibin, and alpha-feto protein by immunohistochemistry.
PMC2989757_02
Metastatic malignant mesothelioma to lymph node. The tumor cells are large and polygonal with eosinophilic cytoplasm. They have prominent nucleoli and display numerous mitoses (H&E, 40x).
PRI2010-846571.005.jpg
PMC2989757_02_PRI2010-846571.005.jpg
fig5
The tumor cells were large and polygonal with eosinophilic cytoplasm, large prominent nucleoli, and numerous mitoses (Figure 5).
PMC2989757_03