PMC3804822_01
A) Hematoxylin & Eosin, 40x; B) Hematoxylin & Eosin, 200x; C) CK5/6, 100x; D) Epstein-Barr Virus, 100x.
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Histopathology on low power showed an unremarkable epidermal surface, with no ulceration or dysplastic changes (Figure 1A). On higher power examination (Figure 1B), the biphasic nature of the lesion became more apparent. Immunohistochemical (IHC) studies showed that the tumor cells were diffusely positively for epithelial differentiation (AE1/AE3 and EMA) and more specifically squamous cell involvement with CK5/6 (Figure 1C). The tumor cells also reacted negativity with Epstein-Barr virus (EBV) (Figure 1D).