PMC4735027_01
Computed tomography scan of the chest. CT of the chest showing anasarca, pulmonary edema, small bilateral pleural effusions, and ill-defined nodular opacities in both lung bases.
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Computed tomography (CT) scan of the chest, abdomen and pelvis demonstrated diffuse anasarca and ill-defined nodular opacities in both lung bases (Fig. 1).
Histopathology. Scanning power micrograph of the bronchial biopsy showing the pulmonary parenchyma with proliferation of spindle cells (arrow) forming cleft like spaces, widening the interstitium and extending to the alveolar septae (H&E stain, 40x magnification).
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The bronchial biopsy showed areas of interstitial spindle cell proliferation extending into alveolar septae (Fig. 2, Fig. 3).
Intermediate power photomicrograph of the bronchial biopsy stained by the immunoperoxidase method for human herpes virus-8 (HHV8) in an area of spindle cell proliferation. The brown stained nuclei (arrow) represent a positive reaction diagnostic of involvement by Kaposi's sarcoma (HHV-8 immunoperoxidase stain, 100x magnification).
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Immunoperoxidase staining for human herpes virus-8 (HHV8) showed positive nuclear staining in the proliferating spindle cells, confirming the diagnosis of pulmonary Kaposi's sarcoma (Fig. 4).