PMC5303837_01
Simplified diagnostic and management algorithm for acute liver failure in neonates. *PT is prothrombin time; **INR is international normalized ratio; ***herpes simplex virus is the most common virus associated with NALF with high mortality rate without early initiation of treatment (cutaneous findings are uncommon); **** includes respiratory chain defects, errors in fatty acid oxidation, and mitochondrial DNA depletion syndromes; ***** includes hereditary tyrosinemia type 1, galactosemia, and hereditary fructose intolerance; ******ET is exchange transfusion; *******IVIG is intravenous immunoglobulin (modified from Taylor and Whitington, 2016).
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fig1
Figures 1 and 2 show a diagnostic algorithm for NLF and GALD-NH, respectively.
Diagnostic and management algorithm for gestational alloimmune liver disease-neonatal hemochromatosis. *GALD-NH is gestational alloimmune liver disease-neonatal hemochromatosis; **IVIG is intravenous immunoglobulin (modified from Lopriore et al., 2013).
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fig2
Figures 1 and 2 show a diagnostic algorithm for NLF and GALD-NH, respectively.
(a) Overview of the patient. (b) Macroscopic view of the liver at autopsy. Analysis of the liver showed multiple nodules in the parenchyma, causing architectural distortion.
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fig3
The liver weighed 136 g, with multiple brownish-green nodules distorting its architecture (Figures 3 and 4).
Perls' stain showing hepatic and extrahepatic siderosis.
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fig4
The liver weighed 136 g, with multiple brownish-green nodules distorting its architecture (Figures 3 and 4).