PMC4531972_01
Portion of the transverse ligament showing deposits of eosinophilic hyaline substance (H&E, x 280).
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These tissues specimens showed multifocal amorphous pinkish deposits in the dense collagenous fibrous bundles in light microscopy, and red colored in hematoxylin and eosin, and Congo red staining (Fig. 1).
Massive amyloid deposits in the transverse carpal ligament (Congo-red. x 100).
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The amyloid protein with Congo red staining exhibited apple-green birefringence under polarized light microscopy (Fig. 2) and electron microscopic examination showed numerous short but thick, nonbranching curvilinear fibrills aligned in parallel and aggregated in bundles (Fig. 3).