PMC3031019_01
The development of fever, skin rash and blood eosinophilia in relation to the insertion of antibiotic-loaded bone cement and the administration of systemic antibiotics. The bone cement was loaded with piperacillin/tazobactam, ceftezol sodium, gentamicin and vancomycin hydrochloride.
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F1
In addition, intravenous ceftezol and vancomycin, as well as oral rifampicin were administered, as shown in Fig. 1. Five days later, a maculopapular skin rash developed (Fig. 1). The blood showed an increased eosinophil count (Fig. 1) and C-reactive protein level (11.4 mg/dL). Body temperature returned to normal one month after the insertion of bone cement (Fig. 1).
Drug provocation test with piperacillin/tazobactam.
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F2
However, the DPT for piperacillin/tazobactam was positive; body temperature increased two hours after intravenous administration of piperacillin/tazobactam 2.25 g, and gradually decreased to normal within 72 hr (Fig. 2).