PMC8650829_01
Kidney biopsy findings. (A) the glomerular compartment is unremarkable: normal capillary wall and no mesangial or endocapillary hypercellularity, renal cortex with inflammation ((A) periodic acid-Schiff stain, original magnification, 200x; (B) electron microscopy exhibiting podocyte focal foot process effacement without changes to the glomerular basement membrane; (C) renal cortex exhibiting mild interstitial edema and inflammation as well as acute tubular injury. (H&E stain, original magnification, 100x); (D) normal capillary walls without mesangial or endocapillary hypercellularity (Jones methenamine silver stain, original magnification, 200x).
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Interstitial fibrosis and tubular atrophy (IFTA) were estimated to involve 20% of the renal cortex (Figure 1A, C and D). Electron microscopy showed non-significant focal podocyte foot process effacement with otherwise unremarkable findings (Figure 1B).