PMC9716442_01
TDM of amisulpride (AMI) during hospitalization. Axis Y: ratio
of amisulpride concentration divided by the dose of amisulpride prescribed
to the patient. The range of C/D ratios for amisulpride should be
0.47-0.87 ng/ml/mg. The median of
amisulpride concentrations in relation to prescribed doses was
0.67.
Axis X: time. Serum levels of amisulpride were measured on day
15, day 26, and day 37. Treatment with amisulpride was started on day 4
(400 mg daily). The dose of amisulpride was changed from 400 to 300 mg on
day 18. The dosage of pregabalin (PGB) was 300 mg daily from day 1 to day
28. Dosing of pregabalin was reduced on day 29 from 300 mg daily to 150 mg
daily.
10.1177_20451253221136754-fig1.jpg
PMC9716442_01_10.1177_20451253221136754-fig1.jpg
fig1-20451253221136754
The course of pharmacotherapy, amisulpride serum concentrations, and measurement of renal functions during hospitalization are set out in Table 1 and Figure 1.