PMC9731974_01
Physical examination findings in a 20-year-old female with DRESS-induced vanishing bile duct syndrome. A, Erythematous papules coalescing into thin plaques on the abdomen. B, Generalized jaundice including scleral icterus. C, Generalized jaundice including the scalp. DRESS, Drug rash with eosinophilia and systemic symptoms.
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A 20-year-old female with a past medical history of bipolar 2 disorder was admitted for a diffuse morbilliform eruption (Fig 1, A) and elevated aspartate transaminase (AST)/alanine transaminase (ALT) (AST/ALT, 128/270 U/L; ref: 9-32/7-33), secondary to lamotrigine. Physical examination demonstrated worsening jaundice including scleral icterus (Fig 1, B and C), increased bruising, and no remaining morbilliform rash.