PMC7670254_01
Lymphocyte count, cytomegalovirus (CMV) blood and cerebrospinal fluid (CSF) viral load, and the progression of symptoms and events over one year, in a 10-year-old girl who underwent allogeneic HSCT. Colour bars represent the timeline graph of antiviral treatments and their corresponding duration. After discontinuing the immune-suppressive regimen, the patient first experienced headaches with high blood CMV load, despite therapy with valganciclovir and foscarnet. Her symptoms then worsened until overt immune reconstitution inflammatory syndrome (IRIS) occurred, with high CSF CMV load, despite CMV clearance from the blood, together with an increase in lymphocyte count and severe bone marrow and renal toxicity. After the initiation of anti-CMV-specific immune globulins, the CSF viral load dropped rapidly, and symptoms improved. HSCT, hematopoietic stem cell transplantation; IST, immunosuppressive therapy; IRIS, immune reconstitution inflammatory syndrome; CMV, cytomegalovirus; CSF, cerebrospinal fluid.
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Serum and cerebrospinal fluid (CSF) cytomegalovirus (CMV)-IgG antibodies (Ab) titre evaluation in CMV-IgG-positive patients undergoing the Cytotect CP treatment (Cytotect group, n = 15) and those not so treated (Control group, n = 15). In the Cytotect group, the CSF CMV Ab levels were significantly higher than serum Ab levels (P < 0.001) and CSF Ab levels of the Control group (P < 0.0001). CMV serum and CSF Ab evaluations were performed in triplicates, and their results are shown as mean +- SD. Statistical analysis was performed using the Mann-Whitney U-test.
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The results are shown in Figure 2.