PMC3483702_01
Photomicrographs showing histological and immunohistochemical findings. (a) The tumour is composed of small-cells with round to fusiform shape, scanty cytoplasm with fine granular nuclear chromatin, absence of nucleoli, and with high mitotic activity (H & E; x200). The tumour cells were immunohistochemically positive for (b) cluster of differentiation 56 glycoprotein, (c) synaptophysin (a neuroendocrine marker) (x200), and (d) CgA (x200).
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PMC3483702_01_CRIM.ONCMED2012-539306.001.jpg
fig1
Immunohistochemical staining was positive for cluster of differentiation 56 glycoprotein (CD56), synaptophysin (Syn), and chromogranin A (CgA) (Figure 1); CD34, CD31, S-100, VIM, GFAP, DES, and MyoD were negative.
Clinical photograph of the "moon face".
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PMC3483702_01_CRIM.ONCMED2012-539306.002.jpg
fig2
Meanwhile, during the radiotherapy the patient also developed symptoms of weakness, hand numbness, finger twitching, facial swelling, and nocturia (Figure 2).