PMC7546332_01
Pedigree of the clustered SARS-Cov-2 infection cases. Arrow indicates the proband (case 1). Case 2, 3, and 4 are close contacts of case 1. Full black fills indicate the individuals with COVID-19 symptoms (case 1 and 2), while partial black fills indicate asymptomatic carriers of SARS-CoV-2 (case 3 and 4).
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F1
He had a fever of 37.8 C and a productive cough after 4 days (Figure 2 and Table 1).
Timeline of the cases exposed to SARS-CoV-2.
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F2
On Jan 19, 2020, case 1 (index patient) visited Wuhan (Hubei, China) for a meeting and then took a train from Wuhan on Jan 21 and arrived at Liaocheng (Shandong, China) on Jan 22 (Figure 2). He had a fever of 37.8 C and a productive cough after 4 days (Figure 2 and Table 1). Case 2 was a close contact of case 1 from Jan 22 to 26, and afterwards she developed to a fever of 38.9 C and cough (Figure 2). After two consecutive negative SARS-CoV-2 nucleic acid tests of nasopharyngeal swabs with 24 h interval, case 1 and 2 were discharged on Feb 15 (Figure 2). As close contacts of case 1 and 2, case 3, and 4 visited the Fever Clinic for further examination on Feb 4 (Figure 2). After 36 days of isolation and observation, case 3's nasopharyngeal swab and fecal samples turned negative for SARS-CoV-2 (Figure 2). For case 4, her nasopharyngeal swab samples turned negative after 22 days of isolation, but the fecal samples have tested positive until now (100 days by May 13; Figure 2).
Chest CT images of the four family-clustered cases. (A) Case 1. (B) Case 2. (C) Case 3. (D) Case 4.
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F3
His chest computed tomogram (CT) scans showed multiple mottling and ground-glass opacities in the bilateral lung (Figure 3A), suggesting this patient has developed to pneumonia. Her chest CT showed multiple inflammatory changes and bronchitis in the bilateral lung (Figure 3B). Both individuals did not show any clinical symptoms, such as fever, chills, cough, sore throat, rhinorrhea, or diarrhea, and no signs of pneumonia was observed on chest CT scans (Table 1 and Figures 3C,D).