PMC3432342_01
Amyloid-beta-related angiitis. (a) Magnetic resonance T2 FLAIR imaging at admission to Neuro ICU note hyperintense lesion in the grey and white matter in the right sensorimotor cortex. (b) Hematoxylin-eosin-stained section shows characteristic double barrel lumen appearance of an amyloid laden vessel. (c) Immunohistochemistry using monoclonal antibody against beta-amyloid reacting to vessels in the meninges and parenchyma. (d) Squash prep at time of surgery-blood vessel and extensive perivascular lymphocytic infiltrate. (e) Lymphocytic response with intramural vascular inflammation. (f) Antibody against CD3 demonstrates a perivascular T-cell infiltrate.
CRIM.PATHOLOGY2012-678746.001.jpg
PMC3432342_01_CRIM.PATHOLOGY2012-678746.001.jpg
fig1
Magnetic resonance imaging with contrast revealed several T2 signal abnormalities in the deep cerebellar white matter, right posterior thalamus, and right posterior frontal gyri (Figure 1(a)). T2 signal abnormalities, as well as surrounding dura mater. The biopsy showed evidence of ABRA (Figure 1(a)).