PMC8695846_01
(A) Erythroderma of the skin prior to alloHSCT. (B) Trephine biopsy (CD3, 15x) with infiltrates of Sezary cells, (C) Skin histology (hematoxilin-eosin stain, 40x) showing diffuse infiltration of the papillary dermis with Sezary cells.
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f1
At presentation an erythroderma involving >90% of the integument was predominant ( Figure 1A ). Immunohistochemistry of both trephine biopsy ( Figure 1B ) and skin histology revealed infiltrations with Sezary cells ( Figure 1C ).
PMC8695846_02
Normalization of CD4:CD8 ratio followed by increase of CD3+ donor chimerism after alloHSCT confirming graft-vs-Sezary effect.
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On day + 172 after alloHCT a complete hematological remission (CR) with no infiltration of SS in bone marrow trephine biopsy, 100% chimerism on sorted CD3 positive cells from bone marrow aspirate and normal pb CD4:CD 8 ratio was documented, thus confirming graft-vs-Sezary effect ( Figure 2 ).