PMC9846320_01
PET-CT revealed an irregular hypodense mass in the lateral segment of left lobe of liver with enhanced FDG drug absorption.
fonc-12-1090634-g001.jpg
PMC9846320_01_fonc-12-1090634-g001.jpg
f1
Prior to postoperative adjuvant therapy, a PET/CT ( Figure 1 ) scan revealed a mild hypodensity mass with a maximum SUV value of 12.0 in the lateral segment of the left hepatic lobe, which was diagnosed as a malignant tumor.
Tumor cells were found in the superficial dermis, the whole epidermis, and the inner corneal layer showed as nested sheets or scattered distribution. The ovoid and polygonal tumor cells had a distinct nuclear membrane, and an eosinophilic nucleolus, as well as abundant cytoplasm and melanin granules and an increased nucleoplasm ratio. Phagocytic melanocytes are found in the superficial dermis.
fonc-12-1090634-g002.jpg
PMC9846320_01_fonc-12-1090634-g002.jpg
f2
Ki-67 was reactive in approximately 40% of the tumor cells ( Figure 2 ).
Glandular formations of varied size, shape, and irregular arrangement that have invaded the submucosa.
fonc-12-1090634-g003.jpg
PMC9846320_01_fonc-12-1090634-g003.jpg
f3
MRI showed an irregular soft-tissue mass with low signal intensity on T1WI (A-C) and slightly high signal intensity on T2WI (D-F) in the lateral segment of left hepatic lobe, as well as dilated adjacent bile ducts, and no clear indication of left portal vein.
fonc-12-1090634-g004.jpg
PMC9846320_01_fonc-12-1090634-g004.jpg
f4
MRCP indicated ( Figure 4 ) multiple liver metastases and biliary obstruction, and tumor progression was considered, so the 4th cycle of immune maintenance therapy was suspended.