PMC9747720_01
a Two glomeruli are globally obsolescent (sclerosed) with capillary tuft of glomeruli with cellular crescents showing few or no inflammatory cell elements. b On periodic acid-Schiff stain, the glomerular basement membranes of unaffected segments show wrinkling and thickening of the glomerular basement membrane. Tubules reveal focal atrophy and interstitium is minimally infiltrated by chronic inflammatory cells.
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F1
A kidney biopsy revealed changes of fibrous crescents with interstitial fibrosis and tubular atrophy with negative immunofluorescence compatible with a systemic disease mediated by ANCA (Fig. 1a, b).