PMC3604866_01
Fundus picture of choroidal tumors in the left eye.
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F1
Fundoscopy revealed 4 elevated, choroidal non-pigmented lesions (fig. 1).
Microphotography of the paraganglioma in the right eye showing nests of spindle-shaped cells, surrounded by fibrovascular septa, typical Zellballen (HE, x10 objective).
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F2
These cells were separated by fibrovascular septa and assumed the typical image of 'Zellballen' (fig. 2).
S-100 staining of the sustentacular cells on the periphery of the tumor nests (x10 objective).
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F3
Immunostaining was negative for HMB-45, Melan-A, SMA, EMA and pancytokeratin, and positive for synaptophysin, neuron-specific enolase and chromogranin; S-100 staining was only positive in the surrounding (sustentacular) cells of the cell clusters (fig. 3). The image shown in fig. 3 is typical of a paraganglioma.