PMC5488594_01
Chest computed tomography scan image show the right lower lobe nodule of the lung
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F1
Chest CT-scan showed a 1.8 cm x 0.9 cm nodule in the right lower lung lobe [Figure 1]. The chest CT scan showed a 1.8 cm x 0.9 cm nodule in the right lower lung lobe [Figure 1].
(a) Papanicolaou stain smears show high grade spindle cell neoplasm. (b) H and E stained section from cell block shows sweeping fascicles of spindle cell lesion with nuclear atypia. (c) Cell block; prostatic specific antigen immunostains highlighted the large atypical epithelial cells. (d) Cell block; cytokeratin adverse event 1/3 immunostains is negative in the large atypical stromal cells. (e) Prostatectomy resection; left lobe shows prostatic stromal sarcoma. (f) Prostatectomy specimen; right lobe, prostatic adenocarcinoma, acinar, type, Gleason score 3 + 3 = 6. (g) Neoplastic spindle cells on cytology. (h) Cytomorphology showing high grade spindle cells
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F2
The biopsy showed malignant neoplasm with mixed spindle and epithelial cell features confirmed to be metastatic PSS with proper immunohistochemical stains [Figure 2a-d]. The morphologic picture and the immunohistochemical profile of the PSS are identical to the lung nodular lesion [Figure 2e and f]. The cells had a fascicular arrangement with focal storiform pattern with no glandular architectures were identified [Figure 2a, b, g and h]. The current case tumor cells were positive for CK AE1/AE3, PSA, PR, CD34, actin, desmin and vimentin, and negative for S100, TTF-1, napsin A, CK 7, CD117, ER, and melan A [Figure 2c and d].