PMC10336209_01
Magnetic resonance imaging (MRI) shows a heterogeneously enhanced intradural lesion in the right frontotemporal lobe with dural enhancement, extending to the superficial cortex. (A) T1W with contrast, (B) T2W, (C) T2W flair, (D) DWI.
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fig1
Magnetic resonance imaging (MRI) with contrast revealed a heterogeneously intradural lesion measuring 19 x 17 cm in the right frontotemporal lobe (Figure 1).
(A) In the transition area between the normal brain (arrowheads) and meningioma (yellow arrow), abnormal small blood vessels and scattered psammomas can be observed. (B) MA area is typical of small blood vessels cuffed by meningothelial cells (white arrows) or fibroblasts proliferation. Tumor cells and perivascular meningothelial or fibroblast-like spindle cells are positive for SSTR2 (C) but lack immunoreactivity for GFAP (D). H&E staining: A x 40; B x 100. Immunohistochemical staining: C,D x 100.
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fig2
In the adjacent cerebral parenchyma to the lesion, significant proliferation of meningothelial cells surrounding the small blood vessels was detected (Figures 2A,B). Immunohistochemical analysis revealed that tumor cells of the meningioma were positive for vimentin, somatostatin receptor (SSTR)-2 (Figure 2C), epithelial membrane antigen (EMA), and progesterone receptor (PR). The perivascular fibroblast-like spindle cells were positive for vimentin and SSTR2 but lacked immunoreactivity for EMA and GFAP (Figure 2D).