PMC8202299_01
Case 1:Edema over the periorbital region and cheek with surrounding erythema.
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Patient denied a history of acne vulgaris. Physical examination revealed periorbital and maxillary facial edema with associated erythema extending over the malar region (Figure 1).
Low power (10x) magnification shows perivascular and perifollicular lymphoplasmacytic inflammatory infiltrate (black arrows) and ectatic superficial dermal blood vessels (green arrow).
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A 4-mm punch biopsy showed mild spongiosis with peri-adnexal mixed infiltrate and dermal edema (Figure 2).
PMC8202299_02
Case 2:Edema predominantly over the periorbital region.
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A 50-year-old Caucasian male with a past medical history significant for latent autoimmune insulin-dependent diabetes mellitus, rosacea, and acne vulgaris presented with chronic periorbital edema (Figure 3).
High power (40x) magnification shows spongiosis which is exaggerated in the dermo-epidermal junction (red arrow).
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A 3-mm punch biopsy showed dermis with perivascular and perifollicular lymphoplasmacytic inflammation, solar elastosis, and superficial dermal telangiectasias (Figure 4).