PMC5015614_01
Spectral domain optical coherence tomography (SDOCT) and infrared images of Case 1. A: Large number of reticular pseudodrusen (RPD) is visible within the macular area on infrared imaging in the right eye. SDOCT shows subretinal deposits with a maximum of stage 3 according to Zweifel et al. B: Large number of RPD is visible within the macular area on infrared imaging in the left eye. SDOCT shows subretinal deposits with a maximum of stage 3. C: After 35 months, number and severity of RPD significantly decreased within the macula on infrared and SDOCT in the right eye. Photoreceptor layer disturbance and alterations of the ellipsoid band are visible. D: RPD in the left eye appeared stable.
OC-04-06-g-001.jpg
PMC5015614_01_OC-04-06-g-001.jpg
F1
His right eye showed dry AMD with RPD (Figure 1A (Fig. 1)), his left eye predominantly classic CNV and RPD (Figure 1B (Fig. 1)). After 35 months, nearly all RPD in the macular area had disappeared on the infrared image and the photoreceptor layer in this area appeared disturbed on SDOCT (Figure 1C (Fig. 1)). In the left eye, RPD appeared stable during follow-up (Figure 1D (Fig. 1)).
PMC5015614_02
Spectral domain optical coherence tomography (SDOCT) and infrared images of Case 2. A: Few reticular pseudodrusen (RPD) were visible in the right eye with a maximum of stage 3 of subretinal deposits according to Zweifel et al. on SDOCT. B: Left eye showed no RPD. C: After 23 months, the number of RPD increased in the right eye. D: Left eye showed no RPD on SDOCT scans. E: After 43 months, RPD nearly completely disappeared within the macula on infrared and SDOCT in the right eye. Outer retinal thinning is visible at this time point. F: On SDOCT scans, no RPD could be detected. On the infrared image, there is evidence for few new RPD at the superior vascular arcades.
OC-04-06-g-002.jpg
PMC5015614_02_OC-04-06-g-002.jpg
F2
Her right eye showed dry AMD and few RPD (Figure 2A (Fig. 2)), her left eye occult CNV without RPD (Figure 2B (Fig. 2)). After 23 months, the number of RPD had increased in the right eye (Figure 2C (Fig. 2)). After 9 injections of ranibizumab, 43 months after baseline, no subretinal deposits were visible on SDOCT scans, only few RPD were present near the superior vascular arcade on infrared images (Figure 2E (Fig. 2)). The left eye was treated with a total of 10 injections and SDOCT scans did not show RPD during follow-up (Figure 2D, 2F (Fig. 2)).
PMC5015614_03
Spectral domain optical coherence tomography (SDOCT) and infrared images of Case 3. A: Reticular pseudodrusen (RPD) are visible within the macular area on infrared imaging in the right eye. SDOCT shows subretinal deposits with a maximum of stage 3 according to Zweifel et al. B: RPD are visible within the macular area on infrared imaging in the left eye. SDOCT shows subretinal deposits with a maximum of stage 3 of subretinal deposits. C: 47 months after baseline, the right eye appeared stable. D: RPD nearly completely disappeared within the macula on infrared and SDOCT images in the left eye. Thinning of the outer retina is visible at this time point.
OC-04-06-g-003.jpg
PMC5015614_03_OC-04-06-g-003.jpg
F3
A 80-year-old male presented with neovascular AMD with predominantly classic CNV and few RPD on his right eye (Figure 3A (Fig. 3)) and dry AMD and RPD in his left eye (Figure 3B (Fig. 3)). The right eye received 22 intravitreal ranibizumab injections during 47 months follow-up, RPD remained stable (Figure 3C (Fig. 3)). After 47 months, RPD had nearly completely disappeared on infrared imaging and only few remaining subretinal deposits were visible on SDOCT (Figure 3D (Fig. 3)).
PMC5015614_04
Spectral domain optical coherence tomography and infrared images of case 4. A: Reticular pseudodrusen (RPD) are visible within the macular area on infrared imaging in the right eye. SDOCT shows subretinal deposits with a maximum of stage 3 according to Zweifel et al. B: RPD are visible within the macular area on infrared imaging in the left eye. SDOCT shows subretinal deposits with a maximum of stage 3 of subretinal deposits. C: 47 months after baseline, RPD decreased within the macula on infrared and SDOCT images in the right eye D: Left eye appeared approximately stable.
OC-04-06-g-004.jpg
PMC5015614_04_OC-04-06-g-004.jpg
F4
A 81-year-old female presented with dry AMD and RPD in her right eye (Figure 4A (Fig. 4)) and predominantly classic CNV and RPD in her left eye (Figure 4B (Fig. 4)). RPD in the right eye remained approximately stable during follow-up (Figure 4C (Fig. 4)). After 47 months, following 25 intravitreal injections, progressive decrease of RPD and subretinal deposits was detected on infrared and SDOCT images (Figure 4D (Fig. 4)).