PMC7547344_01
Photoradiograph showing the patient's teeth before the first extractions.
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Thirty days after the last dose of ramucirumab, the right maxillary central incisor, right maxillary second premolar, left maxillary first and second molars, and left mandibular lateral incisor were extracted (Figure 1).
Photographs showing the healing process of the sockets. (a) Bone exposure was noted 23 days after the extractions in each socket (arrow, sockets of the first molar and second premolar; arrowhead, socket of the third molar). (b) Sixty-one days after the extractions, sockets of the first molar and second premolar were mostly covered with soft tissue (arrow), whereas the socket of the third molar was not covered (arrowhead). (c) Seventy-five days after the extractions, sockets of the first molar and second premolar were almost completely covered with soft tissue (arrow), but the socket of the third molar was only slightly covered (arrowhead). (d) One hundred and seventeen days after extractions, sockets of the first molar and second premolar were completely covered with soft tissue (arrow). However, the socket of the third molar was only partially covered (arrowhead). (e). One hundred and thirty days after extraction, the socket of the third molar was almost completely covered with soft tissue (arrowhead).
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Twenty-three days after the extractions, the patient stated that he was still in severe pain but the pain was better than before (Figure 2(a)). Sixty-one days after the extractions, the pain was considerably diminished, and soft tissue mostly covered the extraction sockets of the first molar and second premolar, but not that of the third molar (Figure 2(b)). Seventy-five days after the extractions, the socket of the third molar was slightly covered with soft tissue (Figure 2(c)). By comparison, the extraction sockets of the first molar and second premolar were completely covered with soft tissue (Figure 2(d)). One hundred and thirty days after the extractions, the extraction socket of the third molar was almost completed covered with soft tissue with almost no pain (Figure 2(e)).