PMC8488421_01
Photographic images of vitiligo with isolated areas of pigmentation on the upper limbs (a) and trunk (b), highlighted by dermatoscopic examination (c).
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F1
Clinical and dermatoscopic examination revealed vitiligo covering > 85% of the skin, with small areas of repigmentation (Fig. 1).
Reflectance confocal microscopy images of apparently normal skin with low pigmentation in the dermal layer (a) and vitiligo lesions (b), showing disappearance of the normal ring structures at the dermo-epidermal junction level with only a shadow of the pre-existing dermal papillary rings and no bright structures detected in the upper epidermal layers.
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F2
Examination by RCM (VivaScope 1500; Maving GmbH, Munich, Germany) revealed disappearance of the bright dermal papillary rings normally seen at the dermo-epidermal junction in depigmented vitiligo lesions (Fig. 2) and activated dendritic melanocytes in repigmented lesions (Fig. 3).