PMC7256313_01
(A) Admission chest x-ray with bilateral pulmonary infiltrates mainly on bases, (B) Progression of bilateral infiltrates at the time of intubation, (C) Extra corporeal oxygenation instauration, (D)Extubated and decannulated patient 7 days after initial imaging.
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She tested positive for influenza B, her chest x-ray on admission showed bilateral interstitial infiltrates (Fig. 1A), and she was started on renally-adjusted oseltamivir (CrCl 14 mL/min). Over the next 48 h, due to increasing oxygen demand and impending respiratory failure the patient was placed on mechanical ventilation (Fig. 1 B) and the oseltamivir dose was doubled. Due to the continuous decline of her respiratory condition, the patient was started on extracorporeal membrane oxygenation (ECMO) on the fourth day of hospitalization (Fig. 1 C). Chest x rays taken 48 h post initiation of baloxavir showed significant improvement of the bilateral pulmonary infiltrates and after another 48 h the patient was taken off ECMO and was extubated three days afterwards (Fig. 1 D).