PMC3829678_01
Computed tomography scan showed an irregular abnormal soft tissue mass located in the left upper lobe.
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Enhanced computed tomography (CT) showed an irregular abnormal soft tissue mass located in the left upper lobe that was approximately 1.7 cmx 0.8 cm in size and obviously enhanced with contrast medium (Figure 1).
(A) Tumor showing the moderately differentiated adenocarcinoma growing with a born formation. Hematoxylin and eosin staining, original magnification x50. Scale bar 1 mm. (B) Mature bony trabeculae in the abundant fibroblastic stroma were surrounded by osteoblasts. Hematoxylin and eosin staining, original magnification x100. Scale bar 600 mum.
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New bone formation was observed at the center of the tumor (approximately 1.25 mm x 0.85 mm, Figure 2A). The bone island consisted of mature bone tissue and was surrounded by osteoblast cells that were accompanied by proliferating fibroblasts (Figure 2B).
(A) On immunohistochemical analysis, tumor cells were positive for cytokeratin 7. (B) TTF-1 immunohistochemistry shows strong nucleus staining in the tumor cells, original magnification x100. Scale bar 400 mum.. Abbreviation: TTF-1, thyroid transcription factor-1.
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Immunohistochemical staining showed that the tumor cells were positive for cytokeratin-7 (Figure 3A) and thyroid transcription factor-1 (Figure 3B), but the metaplastic bone tissue was negative for these factors.