PMC4780707_01
Selection of data for self- controlled case-series analysis.. Cases of IS were primarily identified in the Hospital Discharge Register. Case verification was performed for cases eligible for rotavirus vaccine (under 8 months of age) which occurred during the immunisation programme. Case verification was carried out using Brighton collaboration case definition.
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December 2013 (Fig 2). During the verification 13 (29% of cases) were discarded.
Distribution of intussusception cases according to day of admission.. Cases which have occurred after the first vaccine dose are marked green, after the second dose red and after the third dose blue. Vertical broken line separates the pre-specified risk and control intervals.
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In the SCCS analysis, we had 22 vaccinated cases with date of admission less than 43 days after any of the three vaccine doses (Fig 3). There was no risk detected after the second and third doses: the relative numbers of cases (as is seen in the Fig 3) are 3 divided by 5 and 2 divided by 4, respectively.