PMC6783555_01
Connections between different symptom groups in anti-IgLON5 disease. Each symptom group is represented by a fragment of the outer circular layout. Arcs represent connection and flow between groups. Fragments and arch sizes are equal to percentage of overall symptoms/flow between symptom groups. (A) Shows the combination of all symptoms. Majority of cases experienced sleep disorder and bulbar symptoms, but almost all patients have three symptoms or more. (B) When focusing on patients with sleep disorder, most cases also display bulbar symptoms followed by gait impairment, while association with peripheral symptoms is the rarest combination. (C) Patients with bulbar symptoms mainly have sleep disorder, followed by gait impairment, oculomotor abnormalities and neuropsychiatric symptoms. (D) Patients with movement disorders (mainly chorea and parkinsonism) have associative sleep disorder and bulbar symptoms, but also gait impairment. (E) Oculomotor abnormalities were associated with sleep disorder, bulbar symptoms, and gait impairment. (F) Patients with gait impairment were also found to have mainly sleep disorder, bulbar symptoms, but also neuropsychiatric symptoms. (G) Neuropsychiatric symptoms were associated with mainly sleep disorder, bulbar symptoms, and gait impairment. (H) Dysautonomia was also associated to with these features.
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F1
An overview of symptoms and their association is provided in Figure 1.