PMC8531974_01
PMC8531974_02
skin examination- purpuric nodules on the back, thigh and forearm with a size of 2cm suggesting multiple histiocytofibroma
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F1
Skin examination revealed the presence of purpuric nodules on the back, thigh and forearm with a size of 2cm which appeared a few months ago (Figure 1), and in the biopsy of a skin lesion in the thigh histological appearance of a dermatofibroma (histiocytofibroma) (Figure 2).
skin biopsy- histiocyto fibroma (dermatocyto fibroma): the reticular dermis has a non-encapsulated lesion of moderate cell density made up of spindle cells; the epidermis is acanthotic and has hyperpigmentation; (A: original magnification HEx25); (B: original magnification HEx400)
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F2
Skin examination revealed the presence of purpuric nodules on the back, thigh and forearm with a size of 2cm which appeared a few months ago (Figure 1), and in the biopsy of a skin lesion in the thigh histological appearance of a dermatofibroma (histiocytofibroma) (Figure 2).
external genitalia varicocela
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F3
Examination of the external genitalia revealed normal-sized testes with bilateral hydrocele (Figure 3) confirmed by ultrasound.
panoramic X-ray showing generalized aggressive perodontitis
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F4
The panoramic X-ray showed aggressive periodontitis (Figure 4).
computed tomography scan of the facial mass showing a fistula between the left nasal cavity and hard palate
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F5
The CT scan of the facial mass highlighted a large bucco-nasal communication measuring 1.5cm with a dehiscence of the bony palate opposite the implantation site of the upper incisors (11 and 12) with widening of the desmodental space around the root of 28 rarefaction of the alveolar bone and condensation of the underlying basal bone (Figure 5).
a lymph node biopsy- Langerhans Cell Histiocytosis (LCH) (original magnification HEx100)
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F6
A lymph node biopsy was performed and confirmed the Langerhans Cell Histiocytosis (LCH) based on the morphological (Figure 6) and the immunohistochemical examination which showed that histioid cell cytoplasm and nucleus were positive for CD1a and SP100 marker (Figure 7).
Langerhans Cell Histiocytosis (LCH) (Immunohistochemical stain for Langerhans cell-specific CD1a antigen)
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F7
A lymph node biopsy was performed and confirmed the Langerhans Cell Histiocytosis (LCH) based on the morphological (Figure 6) and the immunohistochemical examination which showed that histioid cell cytoplasm and nucleus were positive for CD1a and SP100 marker (Figure 7).