PMC4836139_01
a MRI (T2-enhanced, coronal image) showing two bladder tumors, one on the left side of trigone (arrowhead) and the other on the right side of the trigone (arrow). b MRI (T2-enhanced, sagittal image) showing a bladder tumor on the left side of the trigone (arrowhead) and perivesical soft tissue invasion. c The average value of the ADC of the tumor was 782 x 10-3 mm2/s.
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F1
MRI revealed that the tumor on the left side of the trigone had invaded the perivesical soft tissue of the bladder, but not the prostate or seminal vesicles (fig. 1a, b).
a-d LELCB in this case. a Microscopic findings at low magnification showed that the tumors had invaded the perivesical soft tissue. H&E stain. b Microscopic findings at high magnification showed that tumor cells (arrows) were surrounded by infiltrating lymphocytes (arrowheads). H&E stain. c Immunohistochemical staining for cytokeratin (AE1/AE3). d Immunohistochemical staining for E-cadherin. e EBER-ISH for this case. Tumor cells were negative. f Lymphoepithelioma of the pharynx in another patient. EBER-ISH of tissues. Tumor cells (arrows) were positive for EBER-ISH (positive control).
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F2
Pathological findings revealed large, undifferentiated carcinoma cells with pleomorphic nuclei and prominent nucleoli, the infiltration of inflammatory cells consisting predominantly of lymphocytes, and the reach of their invasion to the perivesical soft tissue of the bladder (fig. 2a, b). Tumor cells were positive for cytokeratin (AE1/AE3) (fig. 2c) and E-cadherin (fig. 2d).