PMC7605965_01
(A) Case 1. Bilateral GGO with poorly defined margins and multiple patchy opacity with slight thickening of pulmonary interstitial structures. (B) Case 1. Larger extension of the opacities, with parenchymal changes including consolidations and signs of reticular interstitial thickening, linear scarring and volume loss at the upper lobes.
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The swab for the detection of SARS-CoV-2 RNA, collected at nasopharyngeal and oropharyngeal levels in accordance with Centers for Disease Control (CDC) guidelines, resulted positive the same day and the CT scan showed bilateral GGO with poorly defined margins and multiple patchy opacity with slight thickening of pulmonary interstitial structures involving the 50% of the parenchyma (Figure 1A). April 10th, about one month later the onset of initial symptoms, showed a larger extension of the opacities, with parenchymal changes including consolidations and signs of reticular interstitial thickening, linear scarring and volume loss at the upper lobes (Figure 1B). Again, the respiratory failure was present (ABG at room air: pO2 56, pCO2 52, pH 7.28), needing oxygen support with a maximum FIO2 of 60%, but not requiring ventilation.
PMC7605965_02
(A) Case 2. Multiple patchy, nodular or large opacity and GGO under the pleura, with poorly defined margins and few consolidations at the right lower lobe. (B) Case 2. Right sided pleural effusion and the presence of sub-pleural consolidations and reticular thickening involving the upper lobes.
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In this occasion, the CT scan showed multiple patchy, nodular opacity and GGO under the pleura, with poorly defined margins and few consolidations at the right lower lobe with a cumulative extent of 20% (Figure 2A). Because of the delay in recovery and weaning from oxygen support (ABG at room air: pO2 57, pCO2 39, pH 7.48), a CT scan was therefore repeated, showing a right sided pleural effusion and the presence of sub-pleural consolidations and reticular thickening involving the upper lobes (Figure 2B).