PMC7351976_01
Pre-operative imaging of a 44-year-old female with intraepithelial carcinoma in bPRMC (Case 10). Unenhanced and enhanced axial CT scan (A and B) reveals an oval-shaped, well-circumscribed cyst with a thick irregular wall and contrast enhancement in the venous phase, while axial CT scan (C and D) shows a broad-based mural nodule on the front wall with contrast enhancement in the venous phase. CT scan in the coronal (E) and sagittal (F) planes also demonstrates an irregular cyst wall and mural nodules in the venous phase.
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CT results indicated the presence of an enhanced mural nodule of 4.6x1.5 cm and an enhanced thick irregular wall of 6 mm (Figure 2). Consequently, an imaging diagnosis of retroperitoneal cystadenocarcinoma was made.
Surgical highlights and microscopic features of a 44-year-old female with intraepithelial carcinoma in bPRMC (Case 10). The huge cyst was drained laparoscopically and the puncture hole (indicated by the white triangle) was carefully sutured (A). The mass was then put into a specimen bag and was taken out through a trocar hole (B). Hematoxylin-eosin sections show areas of intraepithelial carcinoma marked by severe nuclear atypia (C and D) with haemorrhage and interstitial fibrosis (E). Immunohistochemistry stains show diffuse immunoreaction for CK 7 (F) and CEA (G), as well as focally positive staining for CK 20 (H).
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CK 7 and CEA, as well as focal positive staining for CK 20 (Figure 3). Considering the retroperitoneal location of the mass, the tumour was therefore diagnosed as bPRMC with intraepithelial carcinoma.