PMC5726703_01
Red, dome-shaped and firm nodule on the left cheek
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Physical examination revealed a red, dome-shaped and firm nodule of 13x13 mm in size on the left cheek (Figure 1).
Dense nodular and diffuse dermal lymphocytic infiltrate, separated from
the epidermis by a grenz zone, and admixed with numerous histiocytes and
dendritic cells surrounding the pilosebaceous units. A -
Hematoxylin-eosin, original magnification x 40. B -
Hematoxylin- eosin, original magnification x 100
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A 4-mm punch biopsy was taken and hematoxylin-eosin (HE) stained sections of the specimen demonstrated a dense nodular and diffuse dermal lymphocytic infiltrate, separated from the epidermis by a grenz zone, and admixed with numerous histiocytes and dendritic cells that surrounded the pilosebaceous units (Figure 2).
IImmunohistochemical staining. A - CD3. B -
CD4. C - CD8 and D - CD20
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CD20-positive B-cells and CD3, CD4 and CD8-positive T-cells, with abundant S100 and CD1a-positive dendritic cells surrounding hair follicles, consistent with the diagnosis of pseudolymphomatous folliculitis (Figures 3 and 4). Clonal T-cell receptor and immunoglobulin heavy chain gene rearrangements were not performed.
IImmunohistochemical staining. A - S100 e B -
CD1a
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CD20-positive B-cells and CD3, CD4 and CD8-positive T-cells, with abundant S100 and CD1a-positive dendritic cells surrounding hair follicles, consistent with the diagnosis of pseudolymphomatous folliculitis (Figures 3 and 4). Clonal T-cell receptor and immunoglobulin heavy chain gene rearrangements were not performed.