PMC2827861_01
(A) Single photon emission computed tomographic (SPECT) scan taken after 4 h demonstrating focal uptake of 99m-technetium (99mTc)-labelled neutrophils in the left lower lobe (blue arrow). The red arrow depicts the expected uptake of 99mTc-labelled neutrophils in the vertebral bone marrow. Normal uptake is also seen anteriorly in the sternum and in the ribs. (B) SPECT scan of a matched subject with chronic obstructive pulmonary disease showing minimal activity within the vascular compartment at 4 h and a diffuse signal within the lung fields.
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F1
As shown in fig 1A, the 4 h scan demonstrated unexpected and intense focal activity in the left lower lobe indicative of localised uptake of 99mTc-labelled neutrophils (a 4 h image from an age- and severity-matched current smoking subject with COPD is shown in fig 1B, demonstrating diffuse lung uptake only).