PMC5449580_01
(A) Shoulder CT showing a 9.1 x 5.6 x 5.5 cm destructive expansile lesion at the proximal humeral metaphysis with pathologic fracture and extraosseous soft tissue extension (arrows). (B) Chest CT showing 3.2 x 2.4 x 2.4 cm heterogeneously enhancing soft tissue mass with associated osseous destruction of the fifth right rib at the costochondral junction (arrow). A 2 x 2 cm lytic lesion of the high parietal calvarium near the vertex was identified on head CT (inset, arrow). (C) Abdominal CT showed cirrhotic liver with portal hypertension, moderate perihepatic free fluid, and multiple ill-defined hepatic parenchymal hypodensities abutting the gallbladder fossa (arrow).
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F1
Computed tomography (CT) of the shoulder showed a 9.1 x 5.6 x 5.5 cm destructive expansile lesion at the proximal humeral metaphysis with pathologic fracture and extraosseous soft tissue extension (Figure 1). A 2 x 2 cm lytic lesion of the high parietal calvarium near the vertex was identified on head CT (Figure 1). Abdominal CT showed cirrhotic liver with portal hypertension, moderate perihepatic free fluid, and multiple ill-defined hepatic parenchymal hypodensities abutting the gallbladder fossa (Figure 1).
Biopsy of the shoulder mass showing polygonal eosinophilic cells with round nuclei, prominent cherry-red central nucleoli, and scattered mitotic figures. Tumor cells were immunohistochemically positive for hepatocellular-specific Hep Par1 (inset) and arginase, and showed a CD10 canalicular staining pattern.
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F2
Biopsy of the shoulder mass showed polygonal eosinophilic cells with round nuclei, prominent cherry-red central nucleoli, and scattered mitotic figures (Figure 2). Tumor cells were immunohistochemically positive for hepatocellular-specific Hep Par1 (Figure 2) and arginase, and they had a CD10 canalicular staining pattern.