PMC8740123_01
Clinical presentations of a patient (patient six in Supplemental Table 1) with peripheral anterior synechiae (PAS) after CLASS. (A) Slit-lamp examination (DC-4, Topcon Corporation, magnification 16X) of a 61-year-old male patient at 3 weeks after CLASS. (B) Ultrasound biomicroscopy (UBM) examination indicated PAS (white arrow). (C) Gonioscopy examination confirmed PAS around the treating area (white arrow). (D) After Nd:YAG laser synechiolysis treatment, the iris retreated from the trabeculodescemetic window (TDW) (white arrow). (E) Slit-lamp examination of the patient at 6 months after CLASS showed no obvious filtering bleb. (F) UBM examination at 6 months after CLASS showed no PAS. (G) Gonioscopy examination at 12 months after CLASS showed a second PAS (white arrow). (H) UBM examination confirmed a second PAS (white arrow) at 12 months after CLASS.
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F3
Figure 3 shows the images of a 61-year-old male patient (patient six in Supplemental Table 1), with a baseline IOP of 45.3 mm
PMC8740123_02
Proportions of postoperative laser interventions and success rate after CLASS. (A) Proportions of patients underwent neodymium-doped yttrium aluminum garnet (Nd:YAG) laser synechiolysis and Nd:YAG laser goniopuncture at different timepoints within 1 year follow-up. (B) Changes of complete success (CS) rate, qualified success (QS) rate, total success rate (QS + CS), and failure rate (F) at different timepoints within 1 year follow-up.
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F2
As shown in Figure 2B, the complete success (CS) rate was 91.3% at 1 W after CLASS and decreased to 56.5% at 2 W and only 34.8% at 1 M.
Clinical presentations of a patient (patient 23 in Supplemental Table 1) with scleral reservoir reduction. (A) Slit-lamp examination of a 46-year-old female patient at 1 month after CLASS, with a flat congested bleb at the filtering area. (B) UBM examination indicated a decrease in the scleral reservoir, although the IOP was 6.0 mm Hg. (C) Slit-lamp examination at 2 months after CLASS showed no obvious bleb with conjunctival congestion around the filtering area and the IOP raised to 25.7 mm Hg. (D) Gonioscopy examination indicated no PAS and Nd:YAG laser goniopuncture was performed at the TDW (red arrow) to enhance aqueous humor outflow. (E) Slit-lamp examination of the patient at 9 months after CLASS showed a flat and diffuse bleb. (F) UBM examination at 9 months after CLASS showed an enlarged scleral reservoir with a small hole in the TDW after Nd:YAG laser goniopuncture treatment.
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F4
Clinical characteristics of a patient with iris incarceration (patient 10 in Supplemental Table 1). (A) Slit-lamp examination showed a pear-shaped pupil (white arrow). (B) UBM examination identified iris incarceration (white arrow). (C) Slit-lamp examination showed the pupil shape returned to circular after surgical repositioning. (D) UBM examination showed the iris root returned to normal site after surgical repositioning (white arrow).
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F5
The patient developed iris incarceration and received surgical repositioning at 2 M after CLASS (Figure 5).