PMC4266253_01
(A and B) Right chest wall mass measuring 29.5x26.0x14.0 cm that ulcerated the overlying skin and formed a fungating necrotic skin lesion.
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Physical examination was remarkable for a large, firm, mobile, fungating, right breast mass measuring 29.5x26.0x14.0 cm, with a necrotic core and three ulcerated lesions (Figure 1A and B).
Sectioning revealed a nodular mass having a tan-white fleshy cut surface with both myxoid and fibrous areas, along with scattered areas of necrosis. The area corresponding to the fungating lesion had a necrotic rim with a hemorrhagic cut surface.
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Histopathology of the right breast mass (Figures 2 and 3) showed a malignant, high-grade PT with a tiny focus of invasive ductal carcinoma.
Microscopic examination of the resected specimen (10x magnification) showed a malignant phyllodes tumor with extensive stromal overgrowth (A). The stromal component varied in cellularity, with some areas (50x magnification) having a low-grade appearance (B), while others (50x magnification) had a more high-grade appearance with increased cellularity, nuclear pleomorphism, and numerous mitotic figures (C).
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Histopathology of the right breast mass (Figures 2 and 3) showed a malignant, high-grade PT with a tiny focus of invasive ductal carcinoma.