PMC9037592_01
PMC9037592_02
The treatment timeline. VP, Vincristine + Prednisone; DAC, decitabine; HAAG, homoharringtonine (H), cytarabine (A), aclarubicin (A), granulocyte colony stimulating factor (G-CSF); CT, computed tomography; GM/M, beta-D-Glucan (G); Galactomannan (GM) tests; mNGS, metagenomic next-generation sequencing.
fmed-09-854338-g0001.jpg
PMC9037592_03_fmed-09-854338-g0001.jpg
F1
The antibiotic therapy was then adjusted to amphotericin B liposome, imipenem/cilastatin, daptomycin, piperacillin/tazobactam, and posaconazole (Figure 1). On the 4th day, we infused the maternal neutrophils for 3 days (Figure 1). The antibiotic therapy was then adjusted to imipenem/cilastatin, datamycin, piperacillin/tazobactam, amphotericin B liposome, posaconazole, and caspofungin (Figure 1).
CT images, advancement of skin damage, and morphologic features of microbiological cultures in this case. (A-C) Day 0, day 1, and day 7 of the chest CT images, respectively. (D-G) Day 1, 3, 5, and 7 images of the nasal skin, respectively. (H,I) Bacterial cultures of Staphylococcus haemolyticus and MDR Pseudomonas aeruginosa, respectively. (J,K) The morphologic features of Mucor.
fmed-09-854338-g0002.jpg
PMC9037592_03_fmed-09-854338-g0002.jpg
F2
On the 5th day, the skin of the nose was ulcerated and sunken, which was not alleviated during the course of the treatment (Figures 2F,G). Bacterial cultures of the nasal secretions indicated the presence of Staphylococcus haemolyticus, MDR Pseudomonas aeruginosa, and Stenotrophomonas maltophilia (Figures 2H,I), while fungal cultures suggested Mucor infection after multiple cultures (Figures 2J,K).
PMC9037592_03
The treatment timeline. VP, Vincristine + Prednisone; DAC, decitabine; HAAG, homoharringtonine (H), cytarabine (A), aclarubicin (A), granulocyte colony stimulating factor (G-CSF); CT, computed tomography; GM/M, beta-D-Glucan (G); Galactomannan (GM) tests; mNGS, metagenomic next-generation sequencing.
fmed-09-854338-g0001.jpg
PMC9037592_03_fmed-09-854338-g0001.jpg
F1
The antibiotic therapy was then adjusted to amphotericin B liposome, imipenem/cilastatin, daptomycin, piperacillin/tazobactam, and posaconazole (Figure 1). On the 4th day, we infused the maternal neutrophils for 3 days (Figure 1). The antibiotic therapy was then adjusted to imipenem/cilastatin, datamycin, piperacillin/tazobactam, amphotericin B liposome, posaconazole, and caspofungin (Figure 1).
CT images, advancement of skin damage, and morphologic features of microbiological cultures in this case. (A-C) Day 0, day 1, and day 7 of the chest CT images, respectively. (D-G) Day 1, 3, 5, and 7 images of the nasal skin, respectively. (H,I) Bacterial cultures of Staphylococcus haemolyticus and MDR Pseudomonas aeruginosa, respectively. (J,K) The morphologic features of Mucor.
fmed-09-854338-g0002.jpg
PMC9037592_03_fmed-09-854338-g0002.jpg
F2
On the 5th day, the skin of the nose was ulcerated and sunken, which was not alleviated during the course of the treatment (Figures 2F,G). Bacterial cultures of the nasal secretions indicated the presence of Staphylococcus haemolyticus, MDR Pseudomonas aeruginosa, and Stenotrophomonas maltophilia (Figures 2H,I), while fungal cultures suggested Mucor infection after multiple cultures (Figures 2J,K).