PMC3033007_01
Color fundoscopic images of right a) and left b) eyes 72 hours postingestion demonstrating retinal pallor and cherry red spots. Fluorescein angiograms of right c) and left d) eyes 72 hours postingestion revealing normal retinal vessels.
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Fundoscopy revealed partial resolution of the CRS (Figure 1A, B). Fluorescein angiography showed normal filling times and no evidence of leakage or vascular staining (Figure 1C, D).
OCT images of the macula of the right a) and left b) eyes 72 hours postingestion demonstrating marked thickening and hyper-reflectivity of the inner retina.. Abbreviations: OCT, optical coherence tomography.
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Stratus time-domain OCT revealed inner retinal hyperreflectivity with thickening in both eyes (Figure 2A, B).
Color fundoscopic images of right a) and left b) eyes 28 months postingestion showing attenuated retinal vessels and optic nerve pallor. FA of the right c) and left d) eyes reveals attenuated vessels without evidence of perfusion deficits.. Abbreviations: FA, fluorescein angiography.
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Dilated fundus examination revealed optic nerve pallor OU with retinal atrophy and severely attenuated retinal arterioles and venules (Figure 3A, B). However, normal arteriovenous transit times and arteriolar perfusion were demonstrated by fluorescein angiography (Figure 3C, D).
Time domain OCT images of the macula of the right a) and left b) eyes 28 months postingestion showing atrophy of the neuroretina.. Abbreviations: OCT, optical coherence tomography.
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Macular volumes for a 6 mm diagonal had decreased to 4.68 mm3 OD and 5.06 mm3 OS (Figure 4A, B).
Spectral OCT images of the right a) and left b) eyes 28 months postingestion showing atrophy of the neuroretina.. Abbreviations: OCT, optical coherence tomography.
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FAF photography (TRC-50DX; Topcon, Oakland, NJ) revealed a generalized hyperfluorescent pattern without evidence of atrophic retinal pigment epithelial changes (Figures 5, 6).
Fundus autofluorescence of right a) and left b) eyes 28 months postingestion demonstrating diffuse hyperfluorescence without evidence of RPE atrophic lesions OU.. Abbreviations: RPE, retinal pigment epithelium, OU, both eyes.
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FAF photography (TRC-50DX; Topcon, Oakland, NJ) revealed a generalized hyperfluorescent pattern without evidence of atrophic retinal pigment epithelial changes (Figures 5, 6).