PMC3804044_01
PMC3804044_02
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Case 3, 7 x 17 cm right-sided facial skin and maxillectomy defect after resection of right-sided squamous cell carcinoma.
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She was then taken to the OR by a head and neck oncologist for a right maxillectomy, dermal fat graft, and a large 7 x 17 cm right cervicofacial flap (Figure 1). 
Case 3, one year after completion of external beam radiation therapy. One can see the smooth skin texture. Cheek deformity and combination of paralytic/cicatricial ectropion right lower lid are evident. Reconstruction of these deformities planned in the near future.
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She suffered no further wound breakdown, is now over one year out from her original surgery, and is free of disease (Figure 2).
PMC3804044_04
Case  4 shows 6 cm diameter right cheek defect after melanoma resection with split thickness skin graft closure.
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At the time of surgery he had a 6 cm defect, which was closed with a split thickness skin graft (Figure 3).
Case  4, eight weeks after initial flap reconstruction and now receiving interferon alpha-IIB therapy. Despite severe neutropenia, full epithelialization occurred within 6 weeks of MatriStem placement.
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During this time the patient became extremely neutropenic, and during the next four weeks he had improvement to complete resolution of his wound, despite white blood cell counts being as low as 2000 cells (Figure 4).