PMC2823050_01
Enhanced abdominal CT scan shows an enlarged spleen with multiple low attenuated nodular lesions and liver cirrhosis featuring a nodular surface, heterogeneous density and mild atrophy of the left lobe.
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F1
The abdominal computed tomography (CT) scan showed splenomegaly with the multiple hypodense nodules of different sizes and liver cirrhosis featuring a nodular surface, heterogeneous density and mild atrophy of the left lobe (Fig. 1).
A. T2-weighted abdominal magnetic resonance image shows multiple splenic nodules with high signal intensity. B. T1-weighted abdominal magnetic resonance image shows multiple splenic nodules with iso to low-signal intensity.
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F2
The splenomegaly, with multiple nodules and liver cirrhosis, were found on abdominal MRI (Fig. 2).
The multiple circumscribed blood-filled spongy nodules of 0.2 to 0.6 cm in size located within the spleen that weighed 370 g. The capsule was intact and tensile, with a vaguely micronodular surface. The cut surface of the spleen was a dark purple color and beef-like soft.
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F3
On the serial sections, there were multiple circumscribed blood-filled spongy like nodules of 0.2 to 0.6 cm in size (Fig. 3).
Anastomosing vascular channels with a pseudopapillary pattern and exfoliated cells present in the luminal spaces of the vascular channels (H & E stain, x 400).
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F4
The luminal spaces of the vascular channels contained exfoliated cells (Fig. 4).
Immunohistochemical staining of the splenic nodules. A. Positive staining for the Factor VIII. B. Positive staining for CD31. C. Positive staining for CD68. D. Negative staining for CD34.
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F5
The immunohistochemical staining of the lining cells showed positive for Factor VIII, CD31 and CD68, and negative for CD34 (Fig. 5).