PMC5806670_01
Clinical and gross examination of one-year-old ewe of "Ouled Djellal" breed with nasal tumour. (A): Nasal discharge, exophthalmia, deformation of the frontal bone and facial asymmetry. (B): Sagittal section of the head with tumoral masses ( ). (C): Softening and perforation of the frontal, lacrimal and ethmoidal bones ( ).
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F1
In February 2014, a one-year-old ewe of "Ouled Djellal" breed was presented with persistent sero-mucous nasal discharge, head shaking, muzzle licking, respiratory distress, exophthalmia and frontal protrusion with major facial deformation (Fig. 1A). After longitudinal cut of the head along the midline, bilateral, friable tumour masses were found in the caudal part of the nasal cavity closely attached to the mucous membrane of the ethmoid turbinates (Fig. 1B). Softening, atrophy and perforation were observed in the right side of the frontal, lacrimal and ethmoidal bones (Fig. 1C).
Pathological presentation of the nasal adenocarcinoma (HE, magnification X100). (A): Tubular ( ) and papillary (e) patterns of nasal adenocarcinoma. HE x 100. (B): Papillary (e) projections. Note the epithelial layer composed mainly of non-ciliated cells ( ) with thin oval nuclei and mononuclear cells ( ) infiltrating into the stroma. HEx100. (C): Stroma infiltration of lymphocytes and plasma cell (S) (H&E x100).
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F2
Microscopical examinations showed neoplastic cells arranged in tubular and papillary structures (Fig. 2A). The stromal fibrous connective tissue was infiltrated by numerous lymphocytes, plasma cells and macrophages and varied from scattered to more abundant in some areas (Fig. 2C).