PMC9675090_01
Intraoral examination shows: A - a well-circumscribed mass covered by an erythematous mucosa in the anterior portion of the tongue (Frontal view); B - right lateral view.
autopsy-12-e2021405-g01.jpg
PMC9675090_01_autopsy-12-e2021405-g01.jpg
gf01
The lesion was covered by erythematous surface mucosa (Figures 1A, and 1B).
A - Trans-operative aspect of encapsulated lesion on the submucosa; B - size specimen (scale bar = 1 cm).
autopsy-12-e2021405-g02.jpg
PMC9675090_01_autopsy-12-e2021405-g02.jpg
gf02
SFT. Surgical excision revealed an encapsulated lesion on the submucosa, which supported our previous hypothesis of a benign tumor (Figures 2A and 2B).
Photomicrographs of the biopsy specimen show: A - a dense proliferation of neoplastic cells partially surrounded by a thick fibrous capsule (H&E, 2.5X); B - Staghorn-like vessels (H&E, 10X); C - branching with evident perivascular hyalinization (H&E, 10X); D - Sheet of the spindle to ovoid cells with indistinct cytoplasmic borders (H&E, 40X).
autopsy-12-e2021405-g03.jpg
PMC9675090_01_autopsy-12-e2021405-g03.jpg
gf03
The histological examination evidenced a dense proliferation of neoplastic mesenchymal cells partially surrounded by a thick fibrous capsule (Figure 3A). Staghorn-like vessels (Figure 3B) and branching with evident perivascular hyalinization can be identified (Figure 3C). At high power, tumor cells showed a spindle to ovoid shape with indistinct cytoplasmic borders and a small number of mitotic features (Figure 3D).
Immunohistochemical panel showing the neoplastic cells with: A - diffuse expression of CD34 (10X); B - STAT-6 (10X).
autopsy-12-e2021405-g04.jpg
PMC9675090_01_autopsy-12-e2021405-g04.jpg
gf04