PMC5465775_01
Purplish nodules on lower extremities.
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Ten days later, she developed tender erythematous nodules and plaques on her upper and lower extremities as well as on the abdomen, clinically suggestive of erythema nodosum-like lesions (Fig. 1).
Hemalun eosin, x50 magnification. The infiltrate occurred in fat lobules.
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Histopathological examination showed no specific perivascular lymphohistiocytic infiltrate in the superficial dermis, but in the deep dermis and hypodermis the infiltrate was composed with a predominance of neutrophils (Fig. 2).
Hemalun eosin, x400 magnification. A: Inflammatory compounds (containing polymorphonuclear neutrophils) surrounding hypodermis capillary walls. B: Fibrinoid necrosis of a vascular wall.
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In hypodermis, these neutrophils were located in fat lobules and surrounded some capillary walls with fibrinoid necrosis and nuclear debris (Fig. 3).