PMC5890584_01
(a) Case 1 presented with proptosis and inferior displacement of the left globe. (b and c) Axial and coronal orbital computed tomography demonstrates a tumor about 3.9 cm x 2.2 cm x 3.7 cm in size in the superotemporal orbit. (d) Gross pathology of the excised specimen and tumor marked with stars. (e) Microscopic findings reveal ductal structures with abundant granular eosinophilic cytoplasm (H and E, x100). (f) Immunostain shows strong expression of androgen receptor (x100)
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F1
A 64-year-old male presented with progressive proptosis of the left eye for 3 months [Figure 1a]. Orbital computed tomography (CT) revealed a 3.9 cm x 2.2 cm x 3.7 cm lobulated mass with lateral orbital wall erosion [Figure 1b and c]. He then underwent an orbital exenteration which the gross examination revealed a white firm tumor measuring 3.5 cm x 8 cm x 5 cm [Figure 1d]. The tumor cells were arranged in ductal structures of varying sizes, allying with cribriform pattern [Figure 1e]. Immunohistochemical stains for CK7 [Figure 1f], AR, and gross cystic disease fluid protein 15 (GCDFP-15) were positive.
PMC5890584_02
(a) Case 2 manifested as proptosis and inferior displacement of the right globe. (b-d) Axial and coronal orbital computed tomography demonstrates an infiltrated tumor mass in the lateral orbit of the right eye and destruction of lateral and inferior orbital wall with extension to deep temporal fossa. Focal calcification in the tumor is noted. (e) Microscopic findings revealed ductal structure with comedo necrosis (H and E, x100). (f) Immunostain shows positive nuclear expression for androgen receptor (x100)
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F2
A 64-year-old male presented with proptosis of the right eye and diplopia for 3 weeks [Figure 2a]. Orbital CT showed a mass lesion about 5 cm x 5 cm x 3.3 cm in the right lateral orbital with extensive bony destruction and extension to deep temporal fossa [Figure 2b-d]. The tumor cells have eosinophilic cytoplasm, enlarged nuclei, and prominent nucleoli [Figure 2e]. Immunohistochemically, the tumor is positive for AR [Figure 2f].