PMC9249592_01
(A, B, and C) Extensive, thick, large symmetrical, scaly plaques of elephantine psoriasis over the lower limbs of a 35-year-old patient with chronic myeloid leukemia taking nilotinib.
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On the cutaneous examination, extensive, thick, large, scaly, symmetrical plaques were seen over the medial surface of her thighs, knees, posterior aspect of calves, and dorsum of the foot with well-defined interrupted convex borders (Figure 1).
(A) Histopathologic examination showing psoriasiform acanthosis and parakeratosis (hematoxylin and eosin staining x 100). (B) High power reveals neutrophilic parakeratosis and Munro's microabscess (hematoxylin and eosin staining x 400).
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The histopathologic examination showed hyperkeratosis, neutrophilic parakeratosis, Munro's microabscess, psoriasiform acanthosis, dermal vascular dilatation, and perivascular lymphocytic infiltration (Figure 2).