PMC9263086_01
(A) A pedigree of the family. The arrow indicates the proband. (B, C) Positron emission tomography with computed tomography scanning in (B) the cervical lymph nodes and (C) the right knee joint. (D) Contrast-enhanced magnetic resonance imaging of the synovium of the right knee joint in T1 weighted image. (E) Computed tomography scan of the abdomen.
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The patient was born to a Jewish (Eastern European ancestry) father and a Japanese mother ( Figure 1A ). Tests for hepatitis B and C virus were negative. 18F-fluorodeoxyglucose positron emission tomography with computed tomography scanning demonstrated fluorodeoxyglucose accumulation in the cervical lymph nodes and right knee joint ( Figures 1B, C ). Moreover, magnetic resonance imaging revealed contrast enhancement along the synovium of the right knee joint ( Figure 1D ). Figure 1E ). Fortunately, his condition improved with conservative treatment.
(A) Elastica-Masson staining (x40) and (B) Hematoxylin and eosin staining (x200) of the liver sections.
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AIH was not clear, the overall histopathological image was consistent with that of AIH ( Figures 2A, B ). According to the revised original scoring system of the International Autoimmune Hepatitis Group, our patient had a score of 14 prior to treatment, indicating a probable diagnosis of AIH.
Timeline of the case exhibiting hematological testing, symptom presentation, and treatment.
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Incidentally, methylprednisolone pulse therapy promptly normalized liver enzymes, and he was free of FMF/AIH attacks for 2 y. ( Figure 3 ).