PMC7029763_01
Intra-oral clinical aspect.. Swelling of the right maxillary alveolar ridge, expanded to the right hard palate.
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Conventional oral examination showed an overall swelling of the gingiva surrounding the painful teeth and extending to the right palatal mucosa ( Figure 1), whereas no signs of oral disease could be detected in the lower lip.
Ortopantomography, showing no evidence of any organic lesion in the oral and maxillofacial area.
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Orthopantomography (OPT) showed no signs of odontogenic disease, being completely unremarkable ( Figure 2).
CT scan.. Assial view showing solid mass in right maxilla causing destruction of the maxillary sinus floor.
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Histopathological examination of the sample.. (
A) Hematoxylin & eosin 20x revealing "Starry-sky" pattern from pleomorphic and highly apoptotic lymphocytes and macrophages; (
B) EBER 20x
in situ hybridization positive to EBV-encoded RNA.
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Histology showed in each slide a diffuse infiltration of monomorphic, medium size cells with scarce basophilic cytoplasm, non-cleaved round nuclei, mitotically active with a high rate of spontaneous apoptosis ( Figure 4a). CISH staining for EBV-encoded RNA (EBER) transcript was widely positive ( Figure 4b).
PMC7029763_02