PMC7770176_01
Pedigree of the family carrying the MUTYH mutation c.1187G>A (p.Gly396Asp). CAMA, breast cancer; CRC, colorectal cancer; EC, endometrial cancer (Department of Clinical Genetics, St. Elizabeth Cancer Institute, Bratislava, Slovakia).
fgene-11-590486-g001.jpg
PMC7770176_01_fgene-11-590486-g001.jpg
fig1
The brother of the proband died aged 50 from an unknown gastrointestinal disease (probably gastric cancer; Figure 1).
PMC7770176_02
Pedigree of the family carrying the MUTYH mutations c.1187G>A (p.Gly396Asp) and c.536A>G (p.Tyr179Cys). CRC, colorectal cancer; RCC, renal cell cancer (Department of Clinical Genetics, St. Elizabeth Cancer Institute, Bratislava, Slovakia).
fgene-11-590486-g002.jpg
PMC7770176_02_fgene-11-590486-g002.jpg
fig2
The brother of the proband's father died from RCC at the age of 60 (Figure 2).