PMC4748757_01
Baseline FDG-PET/CT (left) demonstrating an FDG avid tumor is compared to interim FDG-PET/CT after 5 weeks of treatment with RRx-001 (right). The treatment effect is indicated by extensive central tumor necrosis with a thin halo of the apparently viable tumor.
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F1
Five weeks later, due to progressively worsening abdominal pain, he was imaged with PET/CT, which demonstrated an enlarged necrotic mass in the head of the pancreas with a thin capsule of apparently viable tumor (fig. 1).
Pancreatic FNA/cell block analysis. Scoring scale from 1 to 3. Cellularity scale: Ki-67 index, <2% = 1, 2-20% = 2, and >20% = 3. Necrosis scale: punctuate/focal = 1, geographic = 2, and widespread = 3. T-cell scale: number of CD3+ T cells per high-power field (x40), 1 = low, 2 = medium, and 3 = high.
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F2
A comparison of cellularity, necrosis, and T-cell infiltrate before and after treatment with RRx-001 is demonstrated graphically in figure 2, and the degree of necrosis in figure 3.
Hematoxylin and eosin cell block staining before (a) and after therapy (b, 5 weeks from start of therapy) showing decreased cellular viability and a high degree of necrosis.
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F3
A comparison of cellularity, necrosis, and T-cell infiltrate before and after treatment with RRx-001 is demonstrated graphically in figure 2, and the degree of necrosis in figure 3.