PMC9194368_01
The electroencephalogram (EEG) of the patient before treatment. (A) Background activity: 6~7 Hz low to medium voltage theta waves over bilateral occipital regions during wakefulness. (B) Interictal VEEG: spike and slow waves in the left frontal and central regions during wakefulness. (C-F) Ictal EEG: the focal seizure begins with low voltage, fast-wave rhythm over the left frontal and central regions, gradually progressing to spike-and-wave discharges in all regions, predominantly in the left frontal region, lasting about 35 s, during which the electromyography (EMG) burst. The seizure ends and is followed by diffuse background voltage attenuation. (G) Serum anti-LGI 1-Ab: 1:30. (H) One month after treatment, serum anti-LGI 1 Ab is negative.
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F1
Electroencephalography (EEG) revealed slow background activity (Figure 1A) and epileptiform activity in the left frontocentral region (Figure 1B). The ictal video-EEG (VEEG) captured focal epileptic seizures originating from the left frontal and central regions (Figures 1C-F). Abs was detected at a titer of 1:30 (Figure 1G) in the serum and was negative in the CSF. Abs against NMDAR, GABABR, AMPAR, Caspr2, Amphiphysin, CV2, PNMA2 (Ma2), Hu, Ri, Yo, and anti-thyroid Abs were negative in the CSF and serum. One month later, serum anti-LGI1 Abs were negative (Figure 1H).