PMC6626978_01
Schema of surgical and percutaneous Isolated Pelvic and Limb Perfusion (IPLP) with chemofiltration.
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The patient was scheduled for wide surgical excision of cutaneous recurrences combined with locoregional Melphalan (30 mg) chemotherapy by way of Isolated Pelvic and limb Perfusion (IPLP), based upon palliative criteria (Fig. 1).
MCC characteristics: A) Haematoxilin and eosin stain 100 x . Monotonous dermal round cell infiltrate and diffuse pattern of infiltration; B) CD56 100 x . Strong and diffuse immunoreactivity; C) Cytokeratin 20 400 x . Dot-like immunoreactivity; D) RT-PCR demonstrating for MCPyV VP1, small T antigen and large T antigen RT-PCR products from patient RNA.
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Timeline of treatment.
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Within 3 months, the patient also developed an inguinal lymph node recurrence and was subjected to a third round of surgery combined with Melphalan IPLP (Fig. 3). Fig. 3 illustrates the timeline of treatment and location of cutaneous recurrences.