PMC4935918_01
(a) Fundus photograph of the left eye shows central retinal vein occlusion with disk edema, dilated retinal veins, peripapillary cotton-wool spots, and hemorrhages. (b) Fluorescein angiogram (1 minute and 14 seconds after injection of the dye) photograph of the left eye shows central retinal vein occlusion with marked delay in arteriovenous transit time, masked by retinal hemorrhages, vessel wall staining, and a few small patches of retinal capillary obliteration. (c) Fundus photography of the left eye after 8 weeks shows that superficial cotton-wool spots and retinal hemorrhages were all resolved.
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Funduscopic examination revealed severe optic disk edema, superficial retinal hemorrhages with cotton-wool spots in all quadrants, and markedly engorged retinal veins in the left eye (Figure 1(a)). Fluorescein angiography (1 minute and 14 seconds after injection of the dye) showed CRVO with marked delay in arteriovenous transit time, masked by retinal hemorrhages, vessel wall staining, and a few small patches of retinal capillary obliteration (in areas of cotton-wool spots) (Figure 1(b)). Subsequently, cryoglobulins became undetectable, the patient's visual acuity improved to 20/32, and superficial cotton-wool spots and retinal hemorrhages all resolved over an 8-week period in the left eye (Figure 1(c)).
(a) Optical coherence tomography of the left eye shows macular edema (central foveal thickness: 437 mum). (b) Optical coherence tomography of the left eye after 8 weeks (central foveal thickness: 242 mum) (after two monthly ranibizumab injections).
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Optical coherence tomography of the left eye showed macular edema (central foveal thickness: 437 mum) (Figure 2(a)). Macular edema also decreased (central foveal thickness: 242 mum) (Figure 2(b)).