PMC2821763_01
Morphological aspects of ileocecal surgical specimens with intussusception; (a)-(d) Patient 1 (adenovirus infection); (e) Patient 2 (adenovirus infection); (f) Patient 3 (no adenovirus infection). (a) Ileocecal specimen with polypoid intraluminal tumour nodules (arrowhead). The appendix is marked by an arrow. Barr indicates 1 cm. (b) Transmural tissue section of the terminal ileum displaying lymphoid hyperplasia with diffuse lymphocytic infiltration. H/E; original magnification 50x. (c) Dense lymphocytic infiltrates in strong vicinity to nervous plexus with ganglia (arrowheads). Lymphocytes accumulate in subserosal connective tissues. H/E; original magnification 200x. (d) Anti-CD3 immunohistochemistry demonstrates T-lymphocytes in strong vicinity to the intramural plexus cells (plexus border is marked by dotted line). Small vessels crossing the plexus are marked with arrowheads. Original magnification 400x. (e) Tissue section of the terminal ileum (patient 2) demonstrates the plexus myentericus (dotted line) and several infiltrating lymphocytes and eosinophiles (arrowheads). H/E; original magnification 400x. (f) Transmural ileal tissue section (patient 3, adenovirus negative intussusception) with only mild lymphoid hyperplasia and few infiltrating lymphocytes (the nervous plexus is marked by arrowheads). Inset: Strong accumulation of erythrocytes adjacent to the nervous plexus (dotted line), but morphological features of inflammatory neuropathy are not visible. H/E; original magnification 50x; inset 400x.
GRP2009-579501.001.jpg
PMC2821763_03_GRP2009-579501.001.jpg
fig1
Densely packed erythrocytes were found adjacent to the nervous plexus, but morphological hallmarks of inflammatory neuropathy, demonstrated in adenovirus-positive cases 1 and 2, were not visible (Figure 1(f)).
PMC2821763_02
Morphological aspects of ileocecal surgical specimens with intussusception; (a)-(d) Patient 1 (adenovirus infection); (e) Patient 2 (adenovirus infection); (f) Patient 3 (no adenovirus infection). (a) Ileocecal specimen with polypoid intraluminal tumour nodules (arrowhead). The appendix is marked by an arrow. Barr indicates 1 cm. (b) Transmural tissue section of the terminal ileum displaying lymphoid hyperplasia with diffuse lymphocytic infiltration. H/E; original magnification 50x. (c) Dense lymphocytic infiltrates in strong vicinity to nervous plexus with ganglia (arrowheads). Lymphocytes accumulate in subserosal connective tissues. H/E; original magnification 200x. (d) Anti-CD3 immunohistochemistry demonstrates T-lymphocytes in strong vicinity to the intramural plexus cells (plexus border is marked by dotted line). Small vessels crossing the plexus are marked with arrowheads. Original magnification 400x. (e) Tissue section of the terminal ileum (patient 2) demonstrates the plexus myentericus (dotted line) and several infiltrating lymphocytes and eosinophiles (arrowheads). H/E; original magnification 400x. (f) Transmural ileal tissue section (patient 3, adenovirus negative intussusception) with only mild lymphoid hyperplasia and few infiltrating lymphocytes (the nervous plexus is marked by arrowheads). Inset: Strong accumulation of erythrocytes adjacent to the nervous plexus (dotted line), but morphological features of inflammatory neuropathy are not visible. H/E; original magnification 50x; inset 400x.
GRP2009-579501.001.jpg
PMC2821763_03_GRP2009-579501.001.jpg
fig1
Densely packed erythrocytes were found adjacent to the nervous plexus, but morphological hallmarks of inflammatory neuropathy, demonstrated in adenovirus-positive cases 1 and 2, were not visible (Figure 1(f)).
PMC2821763_03
Morphological aspects of ileocecal surgical specimens with intussusception; (a)-(d) Patient 1 (adenovirus infection); (e) Patient 2 (adenovirus infection); (f) Patient 3 (no adenovirus infection). (a) Ileocecal specimen with polypoid intraluminal tumour nodules (arrowhead). The appendix is marked by an arrow. Barr indicates 1 cm. (b) Transmural tissue section of the terminal ileum displaying lymphoid hyperplasia with diffuse lymphocytic infiltration. H/E; original magnification 50x. (c) Dense lymphocytic infiltrates in strong vicinity to nervous plexus with ganglia (arrowheads). Lymphocytes accumulate in subserosal connective tissues. H/E; original magnification 200x. (d) Anti-CD3 immunohistochemistry demonstrates T-lymphocytes in strong vicinity to the intramural plexus cells (plexus border is marked by dotted line). Small vessels crossing the plexus are marked with arrowheads. Original magnification 400x. (e) Tissue section of the terminal ileum (patient 2) demonstrates the plexus myentericus (dotted line) and several infiltrating lymphocytes and eosinophiles (arrowheads). H/E; original magnification 400x. (f) Transmural ileal tissue section (patient 3, adenovirus negative intussusception) with only mild lymphoid hyperplasia and few infiltrating lymphocytes (the nervous plexus is marked by arrowheads). Inset: Strong accumulation of erythrocytes adjacent to the nervous plexus (dotted line), but morphological features of inflammatory neuropathy are not visible. H/E; original magnification 50x; inset 400x.
GRP2009-579501.001.jpg
PMC2821763_03_GRP2009-579501.001.jpg
fig1
Densely packed erythrocytes were found adjacent to the nervous plexus, but morphological hallmarks of inflammatory neuropathy, demonstrated in adenovirus-positive cases 1 and 2, were not visible (Figure 1(f)).