PMC6089094_01
Family heredogram showing the patient's affected family members.. Notes: The patient with XP is represented by the striped square. The XP patient reported a sister (full circle), 2 brothers (solid squares), and a cousin (not shown) with skin cancer.. Abbreviation: XP, xeroderma pigmentosum.
tacg-11-089Fig1.jpg
PMC6089094_01_tacg-11-089Fig1.jpg
f1-tacg-11-089
During his familial history investigation, the patient reported a sister, 2 brothers, and a cousin with skin cancer (Figure 1); however, no details were observed in his records.
Illustrative pictures from a typical ulcerative of BCC and SCC from the face of an XP patient.. Notes: Illustrative pictures from a typical ulceration of BCC (reproduced from Wikimedia commons. [webpage on the Internet]. Basal Cell Carcinoma. Available from https://commons.wikimedia.org/wiki/File:Basal_cell_carcinoma.jpg.) (A) and SCC (B) from the face of an XP patient. H&E staining under 400x magnification of the BCC stained with H&E (400x) Reproduced from Alergodermatoligia. [blog on the Internet]. Available from http://alergodermatologia.blogspot.com.br/2008/06/ cncer-da-pele.html. Carcinoma cells arise in the basal cells and at deepest layer of the epidermis. (C). The lesion shows neoplastic cells among the connective tissue. H&E staining under 400x magnification of the SCC. Neoplastic epithelial cells constitute cell groups that accumulate within the connective tissue of the dermis. Available from https://commons.wikimedia.org/wiki/File:Basal_cell_carcinoma_histopathology_%283%29.jpg. (D) Adapted with permission from Faculty of Medical Sciences of the State University of Campinas (UNICAMP). Pathological Anatomy, Neuropathology and Neuroimaging. [webpage on the Internet]. Available from http://anatpat.unicamp.br/lamneo11.html.). Abbreviations: BCC, basal cell carcinoma; H&E, hematoxylin and eosin; SCC, squamous cell carcinoma; XP, xeroderma pigmentosum.
tacg-11-089Fig2.jpg
PMC6089094_01_tacg-11-089Fig2.jpg
f2-tacg-11-089
We show here, for educational purposes, the SCC and BCC (Figure 2) tumors that were found in the face and wrist of a comparable XP patient.
Illustrative pictures from a typical ulceration of CM form the face of an XP patient.. Notes: Photograph of atypical ulceration of CM from the face of an XP patient (A). H&E staining under 400x magnification (reproduced from Wikipedia. [website on the Internet]. Available from https://pt.wikipedia.org/wiki/Melanoma#/media/File:Melanoma.jpg.). CM originates from melanocytes in the basal layer of the epidermis and infiltrates the dermis (B). (Adapted with permission from Faculty of Medical Sciences of the State University of Campinas (UNICAMP). Pathological Anatomy, Neuropathology and Neuroimaging. [webpage on the Internet]. Available from http://anatpat.unicamp.br/lamdegn17.html.). Abbreviations: CM, cutaneous melanoma; H&E, hematoxylin and eosin; XP, xeroderma pigmentosum.
tacg-11-089Fig3.jpg
PMC6089094_01_tacg-11-089Fig3.jpg
f3-tacg-11-089
At 62 years, an inoperable recurrence of CM (Figure 3) was observed.