PMC3891405_01
Skin lesions of case I. There are numerous, small subcutaneous nodules of neurofibroma and brownish-pigmented lesions (cafe au lait spots) in the trunk.
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F1
A physical examination revealed a large, hard soft-tissue mass bulging out from the middle abdomen, and numerous, small subcutaneous neurofibroma nodules and brownish-pigmented lesions (cafe au lait spots) in the trunk and extremities (Figure 1). An abdominal CT scan demonstrated a large (approximately 9x10 cm) inhomogeneous mass with an area of central necrosis (Figure 2).
Abdominal CT scan of case I demonstrating a large (approximately 9x10 cm) inhomogeneous mass with an area of central necrosis.
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F2
A physical examination revealed a large, hard soft-tissue mass bulging out from the middle abdomen, and numerous, small subcutaneous neurofibroma nodules and brownish-pigmented lesions (cafe au lait spots) in the trunk and extremities (Figure 1). An abdominal CT scan demonstrated a large (approximately 9x10 cm) inhomogeneous mass with an area of central necrosis (Figure 2).
(A) The tumor cells show frequent mitoses of more than five per one high power field (H & E stain, x400). (B) Immunohistochemical stain for the S-100 protein shows a positive reaction.
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F3
The histopathology of the circumscribed and encapsulated mass obtained by a wide excision indicated a MPNST from the mesentery showing frequent mitoses in more than five per one high power field (Figure 3A). In the immunohistochemical stain, the tumor cells stained positively to the S-100 protein, which is a cytoplasmic marker used for identifying Schwann cells (Figure 3B).
PMC3891405_02
Chest PA (A) and CT scan (B) of case II show a homogenous mass measuring 3.5 cmx2.5 cm at the left upper lung field with a well-demarcated margin.
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F4
A chest PA and CT scan demonstrated a homogenous mass measuring 3.5x2.5 cm at the left upper lung field with a well-demarcated margin (Figure 4A, 4B). A wide excision was performed.
Chest CT scan of case II shows an inhomogeneous mass and a large amount of a left pleural effusion.
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F5
A chest CT scan demonstrated an inhomogeneous mass and a large amount of a left pleural effusion (Figure 5).
The chest CT scan shows that the tumor is markedly reduced after chemotherapy.
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F6
After 6 cycles of MAID combination chemotherapy, a CT scan showed that the mass was markedly reduced (Figure 6).