PMC6180957_01
Maculopapular rash.
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Additionally, she reported 4-5 days of erythematous rash that began on her face and chest that then spread to her arms and abdomen (Figures 1-2).
Crusted vesicle.
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Additionally, she reported 4-5 days of erythematous rash that began on her face and chest that then spread to her arms and abdomen (Figures 1-2).
Skin biopsy.
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The patient's dermatologist had performed skin biopsies 2 days prior to admission that showed multinucleated giant cells with viral inclusions suggestive of some type of herpes virus infection (Figures 3-5).
Skin biopsy: intact epidermis on one side and lesion on the other.
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The patient's dermatologist had performed skin biopsies 2 days prior to admission that showed multinucleated giant cells with viral inclusions suggestive of some type of herpes virus infection (Figures 3-5).
Skin biopsy: viral cytoplasmic effect including multinucleated cells and marginalization of chromatin.
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The patient's dermatologist had performed skin biopsies 2 days prior to admission that showed multinucleated giant cells with viral inclusions suggestive of some type of herpes virus infection (Figures 3-5).
Hepatocytes with frank necrosis.
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Liver biopsy was performed which revealed multiple areas of necrotic hepatocytes (up to 35% of liver parenchyma) (Figures 6-7) in zones 2 and 3 of the liver.
Larger foci of hepatocytes with frank necrosis.
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Liver biopsy was performed which revealed multiple areas of necrotic hepatocytes (up to 35% of liver parenchyma) (Figures 6-7) in zones 2 and 3 of the liver.
Areas of necrosis abutting portal triad with chronic minimal inflammation; no significant steatosis seen and no periportal fibrosis or vasculitis appreciated.
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The necrosis also abutted portal triads seen in the specimens (Figure 8).