PMC7103050_01
Multiple gray-white granular nodules present on the patient's skin.
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These nodules gradually progressed to the upper limbs and shoulders in the following six months (Figure 1).
Angiographic flow phase images (blood-pool phase, 0h) showing asymmetric perfusion in the lower extremities.
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Angiographic flow phase images showed asymmetric perfusion in the lower extremities with the left greater than the right (Figure 2).
Delayed images (blood-pool phase, 3h) showing moderate-to-intense uptake related to superficial soft tissues of the left calf muscles.
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Delayed images showed moderate-to-intense uptake related to superficial soft tissues of the left calf muscles (Figure 3).
Fusion images showing the areas of abnormal radiotracer uptake were at the left lateral gastrocnemius muscle.
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Fusion images showed that the areas of abnormal radiotracer uptake were at the left lateral gastrocnemius muscle (Figure 4).
Skin biopsy showing subcutaneous arteriole calcification.
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For further diagnosis and treatment, skin biopsy (pea-sized tissue) was performed, and the results showed subcutaneous arteriole calcification and extensive calcium salt deposition confirming calciphylaxis (Figure 5).