PMC7103042_01
(a) Hypercellular bone marrow core biopsy with lymphocytic infiltrate (arrows) and a few dysplastic cells (hematoxylin-eosin). (b) Reticulin stain demonstrates increased reticulin fibers (arrows). (c) Immunohistochemical staining for CD61 reveals numerous CD61-positive immature cells with megakaryocytic differentiation (arrows).
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PMC7103042_01_CRIPE2020-7813048.001.jpg
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However, her bone marrow core biopsy was hypercellular (>95% cellularity) with a few dysplastic cells (Figure 1(a)). Reticulin stain revealed increased reticulin fibers (Figure 1(b)). Because the BMA and biopsy were nondiagnostic, immunostaining for megakaryocytic marker CD61 was performed on the bone marrow core and revealed numerous (>20%) CD61-positive immature cells that demonstrated histologic megakaryocytic differentiation and appeared in sheets (Figure 1(c)).