PMC5917516_01
(a) Ulceroproliferative growth in right mandibular retromolar trigone (b) Proliferative growth in mandibular anterior region
JOMFP-22-108-g001.jpg
PMC5917516_02_JOMFP-22-108-g001.jpg
F1
Intraoral examination revealed an irregular ulcer approximately 2.5 cm x 3.5 cm in size in the lower right jaw region extending anteroposteriorly from mandibular right lateral incisor to the right retromolar area [Figure 1b].
(a) Orthopantomograph showing slight erosion of underlying bone in lesional area (b) Orthopantomograph showing erosion of the underlying bone in anterior mandibular region
JOMFP-22-108-g002.jpg
PMC5917516_02_JOMFP-22-108-g002.jpg
F2
On radiographic examination, OPG showed erosion of the underlying bone in the anterior mandibular region [Figure 2b] Based on clinical findings, differential diagnosis of squamous cell carcinoma/tubercular ulcer was made.
Stained section showing top to bottom dysplastic features in overlying epithelium (H&E x 10)
JOMFP-22-108-g003.jpg
PMC5917516_01_JOMFP-22-108-g003.jpg
F3
Hence, the diagnosis of carcinoma in situ was given [Figure 3].
Stained section showing nests, cords and gland-like lobules of closely packed basaloid cells with prominent comedo necrosis surrounded by fibrous stroma (H&E, x4)
JOMFP-22-108-g004.jpg
PMC5917516_01_JOMFP-22-108-g004.jpg
F4
The periphery of the neoplastic nests is surrounded by a fibrous stroma with prominent areas of comedo necrosis [Figure 4].
Showing islands surrounded at periphery by pleomorphic hyperchromatic basaloid cells showing palisaded nuclear arrangement with attempt at gland formation (H&E x 40)
JOMFP-22-108-g005.jpg
PMC5917516_01_JOMFP-22-108-g005.jpg
F5
Keratin pearls, increased and abnormal mitotic figures within squamous islands were evident [Figure 5].
PMC5917516_02
(a) Ulceroproliferative growth in right mandibular retromolar trigone (b) Proliferative growth in mandibular anterior region
JOMFP-22-108-g001.jpg
PMC5917516_02_JOMFP-22-108-g001.jpg
F1
Intraoral examination revealed an irregular ulcer approximately 2.5 cm x 3.5 cm in size in the lower right jaw region extending anteroposteriorly from mandibular right lateral incisor to the right retromolar area [Figure 1b].
(a) Orthopantomograph showing slight erosion of underlying bone in lesional area (b) Orthopantomograph showing erosion of the underlying bone in anterior mandibular region
JOMFP-22-108-g002.jpg
PMC5917516_02_JOMFP-22-108-g002.jpg
F2
On radiographic examination, OPG showed erosion of the underlying bone in the anterior mandibular region [Figure 2b] Based on clinical findings, differential diagnosis of squamous cell carcinoma/tubercular ulcer was made.