PMC4041608_01
A) Representative coronal volumetric MRI and B) FDG-PET slices from patient with nv-PPA carrying the P264L Presenilin mutation. Arrow indicates left peri-sylvian volume loss and preserved hippocampi. B) FDG-PET scan indicating patterns of hypometabolism particularly in left temporal and parietal cortices.
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Volumetric MR brain imaging (Figure 1, panel A) revealed global volume loss accentuated within the left cerebral hemisphere. Metabolic brain imaging using FDG-PET (Figure 1, panel B) identified asymmetric hypometabolism within the left hemisphere, most strikingly within the left temporal and parietal lobes. Diffusion weighted imaging (B=1000 s/mm2) was also carried out (see supplementary figure 1).