PMC5670499_01
Photograph of the patient before onset of alopecia, after first alemtuzumab cycle (A). Six months after second alemtuzumab cycle, the patient presented with smooth, circular areas of complete hair loss at both thighs (B). Three months later, the alopecia progressed to a complete loss of all scalp hair with a few remaining thin and pigmented residual hairs (C) and a patchy body hair loss including chest (D), axillae, and pubic region. Eyebrows and eyelashes were extensively involved (E).
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F1
Prior to alemtuzumab treatment, the patient received interferon-beta-Ia i.m., interferon-beta-Ib s.c., and 11 cycles of mitoxantrone with a cumulative dose of 71 mg/m2 without relevant hair loss (Figure 1A). Six months after the second cycle, the patient reported newly emerged smooth, circular areas of complete hair loss at both thighs (Figure 1B). Three months later, the patient complained of progression of alopecia to a patchy body hair loss and complete loss of all scalp hair including eyebrows and eyelashes (Figures 1C-E).
PMC5670499_02