PMC5694027_01
Case 1:Diffuse erythema and thickening of right true cord.
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F1
The left true vocal fold was normal (see Figure 1).
Case 1:Numerous encapsulated cryptococcal organisms (arrows) in vocal cord subepithelial stroma, H&E stain, 40x.
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F2
Histological examination revealed collections of cryptococcal organisms lying within the superficial lamina propria, with an associated inflammatory infiltrate comprising abundant plasma cells, lymphocytes, and some histiocytes (see Figure 2).
PMC5694027_02
Case 2:Mucosal lesion right true vocal cord with focal erythroleukoplakia.
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F3
At microlaryngoscopy her right true cord was found to be inflamed, with focal erythroleukoplakia (see Figure 3).
Case 2:Numerous encapsulated cryptococcal organisms in true cord subepithelial stroma (arrows), periodic acid-Schiff stain positive, 40x.
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F4
Aggregates of Cryptococcus organisms, as confirmed by periodic acid-Schiff and methanamine silver staining, lay in the surface inflammatory crust and within the subepithelial stroma (see Figures 4 and 5).
Case 2:Encapsulated cryptococcal organisms (arrow), methanamine silver stain positive, 40x.
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F5
Aggregates of Cryptococcus organisms, as confirmed by periodic acid-Schiff and methanamine silver staining, lay in the surface inflammatory crust and within the subepithelial stroma (see Figures 4 and 5).