PMC8422814_01
Case #1 with deep vulvar ulcer while receiving secukinumab.
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August 2019 with an 8-month history of recurrent oral ulcers and a 1-month history of a deep painful vulvar ulcer (see Figure 1). After she failed a course of anti-viral therapy prescribed by her family doctor and had two negative vulvar viral swabs for herpes simplex virus as well as a negative polymerase chain reaction (PCR) test for Haemophilus ducreyi, a biopsy was performed, and her family doctor asked her to hold secukinumab.
PMC8422814_02
Case #2 persistent oral ulcer while receiving ixekizumab.
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PMC8422814_02_10.1177_2050313X211034925-fig2.jpg
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In May 2019, the patient presented with a 3-week history of a painful oral ulcer that was not responding to topical anti-fungal therapy (see Figure 2).