PMC4992750_01
CT scan of the abdomen demonstrate a mass, arising from the uncinate process of the pancreas.
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Two years later she started to complain of vague abdominal pain and this was investigated with computed tomography (CT) scans which revealed a 3.5 cm enhancing lesion in the pancreas in addition to multiple uterine fibroids (Figure 1). Immunohistochemical staining of stromal cells was positive for CD117 (c-kit) and DOG-1 and negative for smooth muscle actin, S-100 protein, and ALK-1 (Figure 3 and Table 1).
EUS showing hypoechoic mass in the pancreatic uncinate process during FNA procedure.
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She underwent endoscopic ultrasonography guided fine needle aspiration (EUS-FNA) of the pancreatic lesion (Figure 2).
Pathology shows spindle cell lesion composed of intersecting fascicles and relatively bland spindle cells. (a) CD117, (b) DOG1, (c) spindled tumor cells which are negative for pancytokeratin, (d) atypical spindle cells on H&E stain, and (e) atypical spindle cells on H&E stain.
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Immunohistochemical staining of stromal cells was positive for CD117 (c-kit) and DOG-1 and negative for smooth muscle actin, S-100 protein, and ALK-1 (Figure 3 and Table 1).