PMC4784184_01
Initial clinical presentation:clinical composite photograph of the patient's left eye reveals an extensive fleshy salmon solid tumor of the conjunctiva extending into the orbit inferonasally
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F1
Upon further ophthalmic evaluation, a fleshy, salmon colored conjunctival tumor was identified in her left eye [Figure 1].
Histopathology from biopsied conjunctival lesion:photomicrograph reveals sheets of large neoplastic lymphoid cells with moderate nuclear pleomorphism, vesicular chromatin, and large nucleoli underlying normal epithelium. (H&E, 30X)
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F2
Histopathologic examination of the specimen revealed sheets of large neoplastic lymphoid cells with moderate nuclear pleomorphism, vesicular chromatin, and large nucleoli underlying the normal conjunctival epithelium [Figure 2].
Immunohistochemical stains of conjunctival lesion:photomicrographs of multiple immunohistochemical assays showed that the large lymphoid cells stained strongly positive for CD20 and MUM-1; it was also positive for Pax-5 and weakly positive for Bcl-6. The large lymphoid cells were negative for CD10. The small background lymphocytes stained positive with CD3
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F3
The small background lymphocytes were CD3-positive [Figure 3].