PMC4435291_01
Morphology of core needle biopsy of the liver showed diffuse acute hepatitis with inflammatory infiltrate containing occasional eosinophils.
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F1
Biopsy of the liver showed moderate acute hepatitis with parenchymal necrosis, prominent canalicular cholestasis, and lymphocytic infiltrate (Figure 1).
Graph of liver function tests showing increase in transaminases over 2 weeks, followed by slow recovery over 2 months. Total bilirubin peaked at 23 mg/dL, and was back to baseline in approximately 2 months after discontinuation of sorafenib. Aspartate aminotransferase (AST; blue circle); alanine aminotransferase (ALT; green square); alkaline phosphatase (turquoise triangle); and bilirubin (red diamond).
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F2
His ALT and AST levels peaked to 1,193 U/L and 766 U/L, respectively, prior to total bilirubin peak at 23 mg/dL (direct bilirubin 20 mg/dL) after 2 weeks (Figure 2).