PMC6512746_01
(a) Chest CT revealed right dominant non-segmental infiltrative shadows, multiple nodules, and right pleural effusion. (b) Hematoxylin and eosin staining, detecting some of the alveolar spaces containing Masson bodies (circles) and showing high fibrin precipitation and bleeding (arrows). (c) Grocott's silver staining showing the spherical fungi of different sizes. (d) Treatment course of patient 1.
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fig1
Chest radiograph showed infiltrative shadows in the upper right lobe and right pleural effusion. Chest CT revealed right dominant non-segmental infiltrative shadows, multiple nodules, and right pleural effusion (Fig. 1a). Masson bodies, which was consistent with OP. Moreover, intra-alveolar granulomas and high fibrin precipitation and bleeding, which strongly indicated various degrees of inflammation, were revealed (Fig. 1b). Spherical fungi of large variation sizes of about several mum to 20 mum were revealed by Grocott's silver stain (Fig. 1c). After fluconazole treatment, her symptoms, chest radiograph and CT finding improved (Fig. 1d).
PMC6512746_02
(a) Chest CT revealed non-segmental infiltrative shadows with air bronchogram and surrounding ground-glass opacity in bilateral lungs. (b) A few spores of cryptococcus yeast were detected in the smear of BALF by Grocott's silver stain. (c) Treatment course of patient 2.
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Chest CT revealed non-segmental infiltrative shadows with air bronchogram and surrounding ground-glass opacity in the bilateral lungs (Fig. 2a). A small number of Cryptococcus neoformans was detected from the fungal culture of BALF (Fig. 2b). After antifungal treatment, his hypoxemia, chest radiograph and CT finding were improved (Fig. 2c).