PMC4453162_01
Magnetic resonance imaging of lower extremities demonstrating a left tibial intramedullary lesion with focal extraosseous extension
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F1
Magnetic resonance imaging of the lower extremities revealed a distal left tibial lesion measuring 11.0 cm x 2.1 cm with focal extraosseous extension [Figure 1].
Fine-needle aspiration, left leg, Diff-Quik (x200), showing a cellular yield of cohesive, three-dimensional tumor clusters with cellular overlapping and architectural disorder
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F2
The cytologic smears showed a moderately cellular yield, with the tumor arranged mostly in three-dimensional cohesive clusters with cellular overlapping and architectural disorder [Figure 2].
Fine-needle aspiration, left leg, Diff-Quik (x400), columnar tumor cells arranged in glandular configuration with elongated nuclei, mild to moderate nuclear pleomorphism, and finely dispersed chromatin
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F3
The cells contained elongated nuclei showing mild to moderate nuclear pleomorphism with finely dispersed chromatin and occasional prominent nucleoli [Figure 3].
(a) Fine-needle aspiration, left leg, cell block preparation with cribriform tumor glands (H and E, x400). (b) Estrogen receptor (x400). (c) Thyroid transcription factor-1 (x400). (d) Paired box gene 8 (x400). (e) Mammaglobin (x400)
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F4
The cell block preparation revealed tumor glands arranged in frequent cribriform structures lined by crowded columnar cells [Figure 4].
Hysterectomy specimen showing cribriform tumor glands of endometrioid adenocarcinoma infiltrating the myometrium. H and E (x200)
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F5
Microscopic examination confirmed the diagnosis of FIGO grade 2 endometrioid adenocarcinoma, characterized by myoinvasive neoplastic cribriform glands similar to that seen in the patient's bone FNA [Figure 5].