PMC10212671_01
Ultrasonographic finding of the left thyroid nodule (28 mm x 19 mm in size).
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An ultrasound examination of the thyroid demonstrated a 4 mm x 3 mm nodule in the right thyroid lobe, two nodules in the left thyroid lobe, the smaller one measuring 4 mm x 4 mm in size and the larger one measuring 28 mm x 19 mm in size, which was classified as an ACR TI-RADS 5 nodule (Figure 1).
Macroscopic appearance of the thyroid lobe showing the cut surface of cribriform-morular thyroid carcinoma.
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Macroscopic examination of the left thyroid lobe showed one clean-edged nodule measuring 30 mm x 20 mm in size (Figure 2), while the right thyroid lobe showed no nodule.
Histopathological evaluation of the thyroid carcinoma. (a) Cribriform and papillary growth pattern of tumor cells, low power. (b) Tumor area showing a cribriform growth pattern along with a morular structure (black arrow), high power. (c) TTF-1 was positive in nuclear of tumor cells, high power. (d) TG was negative in tumor cells, high power. (e) beta-Catenin was positive in the cytoplasm and nucleus of tumor cells, high power. (f) CDX2 was positive in the nuclei of the morulae, high power.
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CDX2 was positive in the nuclei of the morulae, while TG was negative in the nucleus and cytoplasm of the tumor cells (Figure 3).