PMC7332717_01
During the initial diagnosis of Vogt-Koyanagi-Harada syndrome, color fundus photographs of the right (A) and left (B) fundus show serous retinal detachment and swollen optic nerve head, venous phase of angiogram depicts fluorescein leakage from the optic disk associated with multiple pinpoint leakages at the posterior pole, (C) right and (D) left eyes; optical tomographic section delineates serous retinal detachment and corrugation of the retinal pigment epithelium/choroid layer in (E) right and (F) left eyes.
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F1
Her color fundus photographs, fluorescein angiogram (FA), and optical coherence tomographic (OCT) examination at the initial diagnosis of VKH syndrome were obtained (Figure 1 (Fig. 1)).
During the initial diagnosis of choroidal neovascularization (CNV), color fundus photographs of the right (A) and left (B) posterior pole show the foveal lesions, venous phase of angiogram demonstrates foveal hyperfluorescence, (C) right and (D) left eyes; optical coherence tomographic section depicts juxtafoveal (E, right eye) and subfoveal (F, left eye) CNV. A week following the left aflibercept injection, subretinal fluid greatly subsided in OS (H, left eye), but the subretinal and intraretinal fluid increased in OD just prior to aflibercept injection (G, right eye).
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F2
Grayish looking juxtafoveal and subfoveal lesions in the OD and OS respectively were noted (Figure 2A and B (Fig. 2)). FA and OCT revealed bilateral type 2 CNV (Figure 2C, D, E, and F (Fig. 2)) without any other findings indicative of active inflammation. Control OCT revealed that the juxtafoveal CNV was enlarged significantly with some intraretinal fluid in OD (Figure 2G (Fig. 2)) whereas the subretinal fluid in OS was mostly resolved (Figure 2H (Fig. 2)).
Eight months after the diagnosis of choroidal neovascularization (CNV), color fundus photographs of the right (A) and left (B) eyes show stable-looking foveas with relatively reduced CNV. Optical coherence tomographic section shows stable CNV without intraretinal and subretinal fluid, (C) right and (D) left eyes. Optical coherence tomographic angiogram (3x3, outer retinal slab) delineates the residual CNV, (E) right eye and (F) left eye.
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F3
Both macular lesions were determined stable upon clinical and OCT examinations, and no further injections were administered (Figure 3A, B, C and D (Fig. 3)). Moreover, OCT angiography pictures were obtained (Figure 3E and F (Fig. 3)).