PMC5313423_01
The clinical course of Case 1.
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A probable diagnosis of DILI was considered, and mosapride and trimebutine were discontinued (Fig. 1).
Liver biopsy at Day 11 showed collapsed hepatocytes in zone 3 with slight infiltration of the acini by inflammatory cells, including lymphocytes and histiocytes.
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Liver biopsy at Day 11 showed the presence of collapsed hepatocytes in zone 3 with slight infiltration of the acini by inflammatory cells, including lymphocytes and histiocytes (Fig. 2).
PMC5313423_02
The clinical course of the Case 2.
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On Day 5, his PT was 45.5% (PT-INR 1.57), and methylprednisolone (500 mg/day) was administered for 3 days based on the diagnosis of acute liver failure (ALF) without hepatic coma (Fig. 3).
Laparoscopy at Day 11 showed reddish markings on the surface of the liver.
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The patient's clinical findings and biological data showed gradual improvement, and laparoscopy on Day 11 showed reddish markings on the surface of the liver (Fig. 4).
Liver biopsy at Day 11 showed distinct interface hepatitis, bridging necrosis with regenerative micronodules, numerous foci of lobular inflammation, and collapsed hepatocytes.
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A histological examination of a liver specimen taken at laparoscopy demonstrated distinct interface hepatitis, bridging necrosis with regenerative micronodules, numerous foci of lobular inflammation and collapsed hepatocytes (Fig. 5).