PMC8668610_01
(A) (Giemsa, 200x) depicts a hypercellular bone marrow, featuring expansion of the eosinophilic lineage, comprising maturing to fully mature eosinophils, while tryptase stain [(B); 200x] delineates the presence of scattered aggregates of epitheliod to spindled mast cells, featuring at least partial CD25-positivity (inset, 400x). Bone marrow biopsy at 3 months from Imatinib initiation [(C); Giemsa, 200x] shows a reduction of cellularity, eosinophilic compartment, and mast cells [(D); tryptase, 200x], which appear scattered. Restitutio ad integrum of the hematopoiesis is steadily apparent in subsequent biopsies [(E, F); Giemsa, 200x], with only scattered tryptase+ cells [(E, F) insets].
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