PMC6487749_01
Case 1: (a) a 2-year-old boy presented with leukocoria of the left eye (OS). (b) Computed tomography (CT) of the orbit showed diffuse infiltrating retinoblastoma OS. (c) Histopathology revealed post-laminar optic nerve tumor infiltration (hematoxylin and eosin stain, 10x magnification) and (d) minor choroidal tumor infiltration (hematoxylin and eosin stain, 40x magnification). (e) Orbital relapse of retinoblastoma with conjunctival chemosis, implant migration, and palpable orbital mass in the left socket. (f) The findings were confirmed by an isodense mass in the left lateral orbit on CT. (g) The tumor regressed with treatment, which is confirmed by CT orbit (h).
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At 2-year follow-up visit, the child had a grade 1 contracted socket, slightly migrated implant, shallow fornices, and a well-fitting prosthesis, with no evidence of persistent or recurrent tumor (Figure 1).
PMC6487749_02
Case 2: (a) a 2-year-old girl presented with preseptal cellulitis and leukocoria of the right eye (OD). (b) Computed tomography (CT) of the orbit showed tumor filling the globe with intratumor calcification. (c, d) Histopathology revealed massive choroidal tumor infiltration (hematoxylin and eosin stain, 10x and 40x magnification). (e) Orbital relapse of retinoblastoma with unstable conformer, shallow inferior fornix, implant migration, and palpable orbital mass in the right socket. (f) The findings were confirmed by an isodense mass in the right inferomedial orbit on CT. (g) The tumor regressed with treatment, which is confirmed by CT orbit (h).
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At 6.5-year follow-up visit, the socket presented a good volume and surface, with a well-centered implant and mild superior sulcus deformity, with no evidence of tumor recurrence (Figure 2).