PMC5588430_01
a Dermal wound after cryotherapy. b Dermal wound after dermal substitute application (Integra ). c Complete wound healing (day 90) after treatment with PG.
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F1
At the first visit, at the Division of Oral and Maxillofacial Surgery, Second University of Naples, Italy, the skin lesion had resulted in a complete loss of epidermis and dermis, was egg-shaped and with a regular circumference (the lesion size measured 6 x 7 x 1.2 cm, width, length, and depth, respectively; fig. 1a). First, the patient was subjected to the dermal substitute application (Integra ; fig. 1b) which required the surgical extension of the injured area. The complete wound healing was observed at the 3-month of follow up (fig. 1c).