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Chest radiograph: a right hilar opacification.
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Chest radiograph demonstrated a right hilar opacification which was thought to be malignant (Figure 1).
A submucosal tumor mass protruding into the luminal airway.
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Direct bronchoscopy revealed an obstruction of the bronchi of the third segment of the right upper lobe by a submucosal tumor mass (Figure 2).
Endobronchial biopsy of granular cell tumor (case 1): A bronchial wall covered with metaplastic, reactive squamous epithelium (yellow star), lying above tumor tissue (arrow) composed of oval to round cells with abundant granular, eosinophilic cytoplasm, with small nuclei (H&E).
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Clusters of cells were separated by delicate fibrovascular stroma (Figure 3).
Immunohistochemistry (case 1): tumor cells were strongly positive for S-100.
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Immunohistochemistry revealed PS100-positive tumor cells (Figure 4).
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Endobronchial biopsy of granular cell tumor (case 2): polygonal tumor cells were infiltrative between bronchial glands (H&E).
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These tumor cells were infiltrative between bronchial glands (Figure 5).
Immunohistochemistry (case 2): S-100 positive.
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Immunohistochemically, all tumor cells were S-100 (Figure 6) and vimentin-positive.
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