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Histopathological and immunohistochemical features of the bone marrow biopsy. (A) Proliferation of large-sized lymphoid cells with large nuclei and conspicuous nucleoli. (B) Lymphoma cells are positive for CD20 (hematoxylin and eosin; magnification, x400).
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Bone marrow aspiration and biopsy revealed hypercellularity with proliferation of large-sized lymphoid cells containing irregular-shaped large nuclei with conspicuous nucleoli (Fig. 1A). Lymphoid cells in the bone marrow were positive for CD20, bcl-2, bcl-6 and MUM1 (Fig. 1B), but negative for CD3, CD5, CD10, CD138 and cyclin D1.