PMC9933358_01
Radiographic computed tomography study of the lesion in the liver in 2007, a cystic lesion 5 mm in diameter (arrow) (A), 2009, the lesion 36 mm in diameter (arrow) (B)
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F1
In addition, abdominal CT showed a well- demarcated lesion 5 mm in diameter in the anterior subcapsular area of the right lobe of the liver (Fig. 1 A). A subsequent ceCT scan of the abdomen revealed multiple solid lesions in the liver ranging from 10 to 36 mm in diameter with homogenous enhancement (Fig. 1 B).
Histopathological analysis of the metastasis in the liver. Haematoxylin and eosin staining showing high-grade metastatic neoplasm (40x and 100x magnification, respectively) (A, B), immunohistochemical staining for the caldesmon shows positivity on the periphery of the lesion (white arrow) and the necrosis in the centre (black arrow) (40x magnification) (C), immunohistochemical staining demonstrates positivity for caldesmon (arrow) (100x magnification) (D)
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F2
Based on histopathological and immunohistochemical results, a diagnosis of leiomyosarcoma G3 was put forward (Fig. 2 A, B). The histopathological examination showed areas of extensive central necrosis and fibrosis in its centre (Fig. 2 C), with atypical cells on the periphery, positive for desmin, HHF35, MIB, and caldesmon and negative for CD117, CD34, myogenin, and SMA (Fig. 2 D), consistent with metastasis of leiomyosarcoma.