PMC3975208_01
a Histology of the biopsy sample. A lot of dilated capillaries were observed in the mucosa (arrows). x100. b Facial appearance: almost no external lesions on the right eyelid. No proptosis can be seen. c, d Close-up view of the superficial lesion at the right medial ocular angle. Superficial tortuous blood vessels are visible.
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F1
In the biopsy sample, a lot of dilated capillaries were observed in the mucosa (fig. 1a, arrows), indicating that the lesion was a capillary hemangioma/malformation, but not infantile hemangioma. It appeared as superficial tortuous blood vessels, and the conjunctiva appeared violet/blue in color (fig. 1b-d).
a Gadolinium-enhanced MRI before treatment, with maximal dimensions of 16 x 11 mm. Internal signal voids (arrows) represent internal high-flow vessels. b After 1 year of topical timolol treatment, a reduction in size (12 x 8 mm, arrow) can be seen.
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F2
The deeper lesion lay posterior to the orbital septum and was detected using MRI with low signal intensity on T1-weighted images versus high signal intensity on T2-weighted images with internal signal void (fig. 2a, arrows) and gadolinium enhancement. The deeper lesion had also reduced in size, with maximal MRI axial dimensions of 16 x 11 mm (fig. 2a), decreasing to 12 x 8 mm (fig. 2b, arrow) after 1 year of treatment.
Close-up view of the superficial lesions. a Photo at initial presentation. The lesions can be seen in the eyelids, conjunctiva and expanding into the subconjunctival space. b Four months later, the lesions were partially reduced. c Eight months later, a clear tendency toward regression can be seen. d After 1 year of treatment, the lesions were nearly absent.
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F3
The superficial lesion gradually regressed, as shown in fig. 3a-c, and had almost disappeared after 1 year of treatment (fig. 3d).