PMC5079240_01
Microscopic examination and IHC study of tumoral cells (x400).. (A) H&E: Discohesive small round cells arranged as vague rosettes.. (B) CD 99: Positive membranous staining in tumoral cells.. (C) NSE: Positive cytoplasmic staining in tumoral cells.. (D) CD 45: Negative in tumoral cells.. (E) CD 56: Negative in tumoral cells.. (F) CK 7: Positive cytoplasmic staining in surface urothelial cells and negative in tumoral cells.. G- CK 20: Negative in surface urothelial cells and tumoral cells.. H- Synaptophysin: Negative in tumoral cells.. I- Chromogranin: Negative in tumoral cells.
gr1.jpg
PMC5079240_01_gr1.jpg
fig0005
PMC5079240_02
Nephrectomy specimen after neoadjuvant chemotherapy. Only a necrotic area was noted in lower pole which failed to prove any residue of tumoral cells in microscopic examination.
gr2.jpg
PMC5079240_02_gr2.jpg
fig0010
Sections of radical nephrectomy showed a yellow soft lesion resembling necrosis in lower pole measuring 2 x 2 x 2 cm (Fig. 2).
PMC5079240_03
CT scan of the third case revealing a large inhomogenous left renal mass occupying the left side of abdomen.
gr3.jpg
PMC5079240_03_gr3.jpg
fig0015
In abdominopelvic contrast enhanced CT scan (Fig. 3) a large left renal mass was confirmed.
Small round cells with high N/C ratio, rather round monotonous nuclei and scanty cytoplasm (x400).
gr4.jpg
PMC5079240_03_gr4.jpg
fig0020
The pathology diagnosis was in favor of ES/PNET of the kidney (Fig. 4, Fig. 5).