PMC4325687_01
(A) Clinical overview image of a new 8 mm bluish nodule (black arrow). (B) Close-up image reveals a pink halo and peripheral tan pigmentation. (Copyright:  2015 Mancebo et al.)
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On the left dorsal forearm, a new 8 mm bluish nodule was detected during photographically assisted examination using total body photography digital images (Figure 1).
Nonpolarized contact dermoscopic image showing central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with irregular tan-brown pigmentation. (Copyright:  2015 Mancebo et al.)
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Non-polarized contact dermatoscopic examination revealed a central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with focal irregular tan-brown pigmentation (Figure 2).
Histopathologic examination revealed a nodular basaloid tumor island budding from the epidermis, stromal retraction, and small cystic spaces filled with mucin and pigment (hematoxylin-eosin, x40). (Copyright:  2015 Mancebo et al.)
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Histopathologic examination of the biopsy specimen revealed a nodular basaloid tumor abutting from the epidermis with mucinous stroma, stromal retraction, and small cystic spaces filled with mucin and melanin pigment (Figure 3). Many atypical melanocytes were identified within the tumor as well as in the adjacent epidermis (Figures 3 and 4).
Histopathologic examination also demonstrated atypical melanocytes as single cells and clusters within the basaloid nodule and along the dermal-epidermal junction (hematoxylin-eosin, x400). (Copyright:  2015 Mancebo et al.)
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Many atypical melanocytes were identified within the tumor as well as in the adjacent epidermis (Figures 3 and 4).
BerEP4 labeled the nodular basaloid tumor, consistent with a diagnosis of basal cell carcinoma (x40). (Copyright:  2015 Mancebo et al.)
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The nodular basaloid tumor stained with BerEp4 (Figure 5).
HMB45 highlighted the atypical melanocytes present in the (A) BCC tumor island as well as the (B) dermal-epidermal junctional (A, x40; B, x200). (Copyright:  2015 Mancebo et al.)
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The atypical melanocyte population within the tumor and along the dermal-epidermal junction stained with HMB-45 (Figure 6A and 6B), A103, and Sox10.