PMC9063658_01
MRI scan indicated dural sinus thrombosis.
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F1
Cerebral angiography in local hospital indicated dural sinus thrombosis (Figure 1) and the patient was given anticoagulation with LMWH, dehydration therapy, neurotrophic treatment and so on.
Erythema at injection sites when the patient was admitted (A). Ulcerations on the scrotum were manifest 2-weeks later (B).
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F2
In physical examination, limited abduction of his left eye, erythema at injection sites (Figure 2A) and raised temperature of skin on the right inner thigh were manifest, together with swelling of bilateral lower limbs, particularly in the right. Meanwhile, the patient began to exhibit two ulcers on the scrotum (Figure 2B).
Sequencing analysis of the patient revealed a heterozygous mutation in TFPI.
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F3
TFPI (NM_006287; c.C403T: p.R135X; Figure 3).