PMC3936946_01
Histological and immunohistochemical findings. (A) Micrograph of hematoxylin and eosin stained section of surgical specimen showing invasive ductal carcinoma proliferating in a trabecular manner (x40). (B) Micrograph of immunohistochemical stained section of surgical specimen showing the tumor cells have strongly positive nuclear staining for estrogen receptors (x100). (C) Micrograph of immunohistochemical stained section of surgical specimen showing the tumor cells have strong membrane staining for human epidermal growth factor receptor 2 (2+ score) (x100)]. (D) The Ki-67 (MIB-1, DAKO, 1:100) labeling index is 5%.
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Immunohistochemical (IHC) examination of the tumor cells was positive for estrogen receptors, negative for progesterone receptors, and showed moderate membrane staining for human epidermal growth factor receptor 2 (HER-2) (2+ score) (Figure 1).
(A) CT image obtained 12 months postoperatively showing multiple nodular shadows in both lungs (white circle). (B) CT image obtained 3 months after commencing exemestane showing the lung metastases have resolved completely with no development of new lesions.
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Twelve months postoperatively, in May 2006, she was asymptomatic, yet screening computed tomography (CT) revealed multiple nodular shadows in both lungs (Figure 2A), which were diagnosed as metastases to the lungs with a 12-month disease-free interval. Three months after this treatment change, a CT scan showed a CR of her lung metastases with no development of any new lesions (Figure 2B).