PMC6332809_01
(A) A microphotograph of the blood smear showing small lymphoid cells with dense chromatin. Their nucleoli and their cytoplasmic expansions suggested the hypothesis of a T-prolymphocytic neoplasm. (B) Complex karyotype involving no less than six pairs of chromosomes, forming a typical profile of T-PLL. (C) FISH analysis.
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Cytoplasmic expansions (blebs) were present (Fig. 1A). Furthermore, these abnormal nuclei could be subdivided in two different type, as a first one carried an additional monosomy of chromosome 15, and a second carried a rearrangement in both long arms of chromosomes 1 and 3, suggesting a potential translocation t(1;3) (Fig. 1B). Among these abnormalities, 14 inversion is a characteristic lesion of T -PLL, which is frequently included in complex karyotype. ATM involvement is also recurrent 3 (Fig. 1C).