PMC10368100_01
a Color fundus photography of the right eye shows a clear vitreous with optic disc neovascularization, posterior pole cotton wool spots, and a hyperemic disc. b Color fundus photography of the left eye shows a vitreous hemorrhage, with a hyperemic disc.
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F1
In OD, the vitreous was clear, while a vitreous hemorrhage was observed in OS (Fig. 1).
Fluorescein angiography of both eyes at presentation. In the arteriovenous frames, disc (a, b) and retinal (c, d) neovascularization can be seen. In (a, b) and (c, d), numerous saccular venular dilations can be observed. In (a), arteriolar saccular dilations can also be seen. In the late frames (e, f), a strong leakage of the disc neovascularization can be appreciated, along with staining of the vessel walls and segmental paravascular leakage.
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F2
In addition, posterior pole venular and arteriolar saccular dilations were also present in OD (Fig. 2).
a, b Color fundus photographs of both eyes. The bilateral disappearance of the discal neovascularization and the saccular dilations. c, d Arteriovenous frames of the fluorescein angiogram. The disappearance of the retinal neovascularization. There is also a significant regression of the saccular dilations. e, f Late frames of fluorescein angiography at the posterior pole reveal the disappearance of disc neovascularization, with persistence of papillitis and a mild diffuse macular edema in both eyes. There is also a complete disappearance of the saccular dilations.
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F3
Fluorescein angiography after the third dose revealed a dramatic reduction of retinal and disc neovascularization, with disappearance of retinal vasculitis, although a mild retinal edema and papillitis persisted in both eyes (Fig. 3).