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Diagram showing patient enrollment.
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Twenty-one lesions fulfilled all the inclusion criteria ( Fig. 1 ).
Case 5: Lesion with lateral progression and deep progression (submucosal cancer to advanced cancer).
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 The lesion was estimated to be submucosal cancer because of SMT (submucosal tumor)-like marginal elevation ( Fig. 2a ). Twelve months later, it was up to 100 mm and the depression progressed more deeply ( Fig. 2b ). The lesion was finally estimated to be cancer invading into the muscularis propria or deeper ( Fig. 2c ). 
Case 21: Lesion with lateral progression and deep progression (submucosal cancer to advanced cancer).
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 The lesion was estimated to be submucosal cancer ( Fig. 3a ) by the thickness and marginal elevation. Twelve months later, it was up to 50 mm and estimated to be muscularis propria cancer because the thickness and elevation became more obvious ( Fig. 3b ). 
Case 11: The lesion was initially diagnosed as intramucosal cancer, and the diagnosis has remained mucosal cancer for 110 months.
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