PMC6677001_01
(a) Photomicrograph showing tumors cells in polypoidal growth (H and E, x100) and (b) photomicrograph showing tumors cells arranged in tubules and micropapillary fashion (H and E, x100), (c) photomicrograph showing sheets of tumor cells with clear cytoplasm (H and E, x100), (d) photomicrograph showing urothelial carcinoma in situ (H and E, x100)
NMJ-60-40-g001.jpg
PMC6677001_01_NMJ-60-40-g001.jpg
F1
Sections from polypoidal growth [Figure 1a] seem to be composed of cells arranged in tubules, papillae, and tubulocystic areas and at places trabeculae [Figure 1b]. Many cells showed clear cytoplasm [Figure 1c]. Lining epithelium surrounding the tumor showed urothelial carcinoma in situ [Figure 1d].
(a) Photomicrograph showing CK7 immunoreactivity (x100), (b) photomicrograph showing Ki67 expression (x100), (c) photomicrograph showing p53 immunoreactivity (x100)
NMJ-60-40-g002.jpg
PMC6677001_01_NMJ-60-40-g002.jpg
F2
Tumor cells showed immunoreactivity for CEA and CK7 [Figure 2a]. Ki67 labeling index [Figure 2b] and p53 [Figure 2c] immunoreactivity were 90% and 95%, respectively.