PMC5065632_01
Radiological findings. A CT scan shows a well-circumscribed nodule in S6 of the right lung.
gr1.jpg
PMC5065632_01_gr1.jpg
fig0005
A computed tomography (CT) scan showed a well-circumscribed nodule in segment 6 (S6) of the right lung (Fig. 1).
Microscopic findings. (A) The tumor was highly hemorrhagic and necrotic. H.E. stain, x10. (B) An intimate admixture of atypical cytotrophoblasts and syncytiotrophoblasts arranged in nests without a villus structure is visible. H.E. stain, x20. (C) Tumor cells were strongly positive for hCG. Immunohistochemistry against beta-hCG, x20.
gr2.jpg
PMC5065632_01_gr2.jpg
fig0010
The histopathological findings showed that the tumor was highly hemorrhagic and necrotic and consisted of an intimate admixture of atypical cytotrophoblasts and syncytiotrophoblasts arranged in nests without a villus structure (Fig. 2A and B). The immunohistological findings indicated that the tumor cells were strongly positive for human chorionic gonadotropin (hCG) (Fig. 2C) and positive for cytokeratin (CK) 7, but were negative for thyroid transcription factor-1, alpha fetoprotein, and CK 20.