PMC9128050_01
Treatment approach/follow-up timeline and results for CVI class C6 ((CEAP) classification) patient using AF and AM. (a) Treatment approach and timeline (FU = follow-up). (b) Qualitative analysis and images for medial wound. (c) Quantitative analysis of medial wound dimensions over treatment time course showing maximum measured values of length, width, and depth of wound in centimeters (note: medial wound closure observed at 4 weeks; no data (ND) recorded for two last follow-ups). (d) Qualitative analysis and images for lateral wound. (e) Quantitative analysis of lateral wound dimensions over treatment time course showing maximum measured values of length, width, and depth of wound in centimeters. (f) Qualitative image of lateral wound at week 17 follow-up visit.
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Therapeutics Inc., Research Triangle, NC, USA) were used for biologic therapy. The treatment course lasted for 10 weeks, with a follow-up at 17 weeks (Figure 1(a)). Both medial and lateral wounds were assessed qualitatively and quantitatively 4 weeks prior to initial treatment (Figure 1(b)-(e)). A total of three treatment sessions were performed over 10 weeks and a final observation was conducted at week 17 (Figure 1(a)). When the patient arrived for the first treatment, both the medial (Figure 1(b) and (c)) and lateral (Figure 1(d)) wounds were non-healed despite successful RFA. During the first treatment (Figure 1(b) and (d) "week 0"), two 2 mL vials of Dermacyte  Liquid were diluted 1:1 (8 mL total volume) and injected around the wound bed periphery of the lateral VLU and one 2 mL vial (4 mL total diluted solution) was used for the medial VLU. Interestingly, closure of the medial wound was observed after 4 weeks and its treatment was discontinued (Figure 1(b) and (c)). The lateral wound also showed qualitative (Figure 1(d)) and quantitative improvement during the 4-week time (Figure 1(e)). Additional reduction in wound size was observed at weeks 8 and 10 (Figure 1(d) and (e)). At the 17-week follow-up, the patient demonstrated almost complete wound closure with significant areas of re-keratinization (Figure 1(f)).