PMC5726694_01
Clinical aspect of the histoplasmosis lesion: granular ulcer with red and
yellow dots in the hard-soft palate
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An 81-year-old male Caucasian patient was referred to our unit with a lesion on the soft palate that had appeared three months before (Figure 1).
Histopathological aspects of histoplasmosis. A:
microphotograph showing diffuse infiltrate of epithelioid macrophages
containing H. capsulum (arrow). Presence of
lymphoplasmacytic inflammatory infiltrate with polymorphonuclear
neutrophils (Hematoxylin & eosin, X400). B:
microphotograph showing small particles of H.
capsulatum measuring between 1 and 2microm (arrow).
(GMS, X200)
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The slides with the specimens were stained with hematoxylin-eosin (HE) and Gomori's methenamine-silver (GMS), confirming the presence of the fungus (Figure 2).
Radiograph revealed micronodules and fibroatelectatic changes, which are
nonspecific and may be residual, associated with smoking and COPD. There
is no evidence of active pleuropulmonary lesions
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The patient was referred to assess pulmonary involvement, and there was no evidence of active pleuropulmonary lesions (Figure 3).
Clinical aspect of the lesion 30 days after starting treatment
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Itraconazole 200 mg/day was prescribed for the treatment of oral histoplasmosis, with significant improvement after 30 days (Figure 4).