PMC9149489_01
Motor nerve conduction studies (Median nerve/APB) from a normal subject (a) and a patient with IgM paraproteinaemic polyneuropathy and anti-MAG antibodies (b). Abnormalities demonstrated in B are reduced motor amplitude; severe prolongation of the distal motor latency (from wrist stimulation to the muscle); and mild slowing of the motor conduction velocity (wrist to elbow), indicating predominantly distal slowing, characteristic of the disorder.
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F1
These findings were diagnostic of WM (lymphoplasmacytic lymphoma) with suspected related sensorimotor neuropathy (shown in Fig. 1).
Axial MRI scans demonstrating lesions suggestive of malignant tumour with surrounding vasogenic oedema (T2 weighted images - Cases 1 and 2; gadolinium-enhanced T1-weighted image - Case 3).
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F2
MRI demonstrated an enhancing lesion in the right frontal lobe, suggestive of a malignant neoplasm (shown in Fig. 2).
Biopsies from all 3 patients showed features of Glioblastoma, IDH-wildtype (WHO grade IV) with pleomorphic astrocytic cells, mitotic activity, microvascular proliferation (Case 1) and necrosis (Cases 2 and 3). In each case, the cell proliferation index assessed by ki67 immunohistochemistry was high. IDH1 was assessed as nonmutated by lack of staining for the common IDH-1 (R132H) mutation specific antibody.
crn-0014-0213-g03.jpg
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F3
The patient underwent a craniotomy for partial debulking, with histological analysis confirming glioblastoma IDH-wildtype (WHO grade IV) with GFAP immunoreactivity, lack of staining for IDH1 (R132H), retained ATRX and a high Ki67 proliferation index (shown in Fig. 3).
PMC9149489_02
Axial MRI scans demonstrating lesions suggestive of malignant tumour with surrounding vasogenic oedema (T2 weighted images - Cases 1 and 2; gadolinium-enhanced T1-weighted image - Case 3).
crn-0014-0213-g02.jpg
PMC9149489_03_crn-0014-0213-g02.jpg
F2
MRI demonstrated an enhancing lesion in the right frontal lobe, suggestive of a malignant neoplasm (shown in Fig. 2).
Biopsies from all 3 patients showed features of Glioblastoma, IDH-wildtype (WHO grade IV) with pleomorphic astrocytic cells, mitotic activity, microvascular proliferation (Case 1) and necrosis (Cases 2 and 3). In each case, the cell proliferation index assessed by ki67 immunohistochemistry was high. IDH1 was assessed as nonmutated by lack of staining for the common IDH-1 (R132H) mutation specific antibody.
crn-0014-0213-g03.jpg
PMC9149489_03_crn-0014-0213-g03.jpg
F3
The patient underwent a craniotomy for partial debulking, with histological analysis confirming glioblastoma IDH-wildtype (WHO grade IV) with GFAP immunoreactivity, lack of staining for IDH1 (R132H), retained ATRX and a high Ki67 proliferation index (shown in Fig. 3).
PMC9149489_03
Axial MRI scans demonstrating lesions suggestive of malignant tumour with surrounding vasogenic oedema (T2 weighted images - Cases 1 and 2; gadolinium-enhanced T1-weighted image - Case 3).
crn-0014-0213-g02.jpg
PMC9149489_03_crn-0014-0213-g02.jpg
F2
MRI demonstrated an enhancing lesion in the right frontal lobe, suggestive of a malignant neoplasm (shown in Fig. 2).
Biopsies from all 3 patients showed features of Glioblastoma, IDH-wildtype (WHO grade IV) with pleomorphic astrocytic cells, mitotic activity, microvascular proliferation (Case 1) and necrosis (Cases 2 and 3). In each case, the cell proliferation index assessed by ki67 immunohistochemistry was high. IDH1 was assessed as nonmutated by lack of staining for the common IDH-1 (R132H) mutation specific antibody.
crn-0014-0213-g03.jpg
PMC9149489_03_crn-0014-0213-g03.jpg
F3
The patient underwent a craniotomy for partial debulking, with histological analysis confirming glioblastoma IDH-wildtype (WHO grade IV) with GFAP immunoreactivity, lack of staining for IDH1 (R132H), retained ATRX and a high Ki67 proliferation index (shown in Fig. 3).