PMC9925237_01
Patient presentation at rash onset.
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At the clinic visit, physical examination was notable for scattered pink dermal papules with a dusky red center bilateral dorsal and palmar hands, as well as bilateral conjunctival erythema (Figure 1).
Histology on low (hematoxylin-eosin stain; original magnifications: (a) x 20) and high (hematoxylin-eosin stain; original magnifications: (b) x 200) power show a moderately dense perivascular and interstitial inflammatory infiltrate composed of lymphocytes, histiocytes, and numerous neutrophils with surrounding papillary dermal edema. (c)/(d). High power views demonstrate scattered nuclear dust (karyorrhexis) and fibrin within the walls of the small blood vessels with extravasation of red blood cells in the surrounding stroma (hematoxylin-eosin stain; original magnifications: (c) x 400; (d) x 400).
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High-power views demonstrated scattered nuclear dust and fibrin within the walls of the small blood vessels with extravasation of red blood cells in the surrounding stroma (Figure 2).
Rash at one week follow-up.
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The patient followed up one week later with a more typical appearing rash for LCV (Figure 3).