PMC5216146_01
(A) Mulberry cells in the urine sediment. The appearance resembles a mulberry. Magnification is x400 and scale bar represents 10 mum. (B) A mulberry body in the urine sediment. A lamellar appearance is the characteristic picture of mulberry bodies. Magnification is x1,000 and scale bar represents 10 mum.
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Regular urinalysis tests showed proteinuria (548 mg/gCre), and mulberry cells and bodies in the urinary sediment (Fig. 1).
Light microscopic image of a kidney biopsy sample. Enlarged and vacuolated podocytes are shown. Vacuolated change was also observed in some of the tubular epithelium cells (periodic acid-Schiff stain x400).
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The other twenty-five glomeruli contained strikingly enlarged and vacuolated podocytes (Fig. 2).
Electron microscopic image of a kidney biopsy sample. Myelin-like bodies are present in the podocytes (x2,500).
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Enlarged lysosomes packed with lamellated membrane structures (myelin-like bodies) were detected in podocytes by electron microscopy (Fig. 3), and the rate of foot process fusion was 50 %.