PMC10084863_01
Clinical appearance before and 28 weeks after the treatment with Ustekinumab. (A-C) Clinical appearance of the dorsum of the hand, nails, flexion side of fingers and the right forearm before the treatment with Ustekinumab. (D-F) Clinical appearance of the dorsum of the hand, nails, flexion side of fingers and the right forearm 28 weeks after the treatment with Ustekinumab.
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Further examination revealed that anonychia occurred on five fingers, three fingernails were dystrophic, and seven fingers could not be fully extended (Figure 1A-C). The pain was completely eliminated half a month after the first injection, and improvement in the skin lesions was observed 4 weeks after the treatment, and the skin lesions were almost completely resolved after the third treatment (28 weeks after the initiation of the treatment) (Figure 1D-F; for details of the timeline, see Figure 2).
The timeline of the course of disease.
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The pain was completely eliminated half a month after the first injection, and improvement in the skin lesions was observed 4 weeks after the treatment, and the skin lesions were almost completely resolved after the third treatment (28 weeks after the initiation of the treatment) (Figure 1D-F; for details of the timeline, see Figure 2).