PMC3863985_01
Brain Activity During Production of English Sentences Containing a Large Number of Vowels.. Before treatment with sodium oxybate (A), 90 minutes after treatment (B), and 8 months after treatment (C). Brain activity is shown on the inflated brain surfaces in the standard Talairach-Tournoux space and on the series of axial slices. The color bar represents t score.
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PMC3863985_01_tre-03-206-4731-1-g001.jpg
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Sentence production showed bilaterally increased brain activity in the sensorimotor cortical regions, basal ganglia, and cerebellum (Figure 1A), which was in line with abnormal brain activity found in larger studies in SD patients. Post-treatment fMRI, which was conducted 90 minutes after the drug intake when the patient had improved voice symptoms, showed significantly attenuated brain activity in the primary sensorimotor cortex (right>left), putamen, and cerebellum (Figure 1B). The brain activity during speech production remained attenuated in the basal ganglia and cerebellum with further normalization of activity in the bilateral sensorimotor cortices compared with the first post-treatment scan (Figure 1C).