PMC3484813_01
Neoplastic cells growing in poorly defined glandular structures were seen at the periphery of the biopsy (H&E).
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figure1
A tru-cut biopsy of the breast lump confirmed that it was an invasive carcinoma (Figure 1), the tissue was positive for hormonal estrogen and progesterone receptors (50%), HER-2 expression was complete and intense in 70% of neoplastic cells (3+), and Ki-67 expression was positive in 20% off cells (Figure 2). A bone scan indicated secondary bone lesions (sternum, left humeral head,
Neoplastic cells were positive for ER, PgR and HER2/neu and are characterized by a high proliferative fraction.
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figure2
A tru-cut biopsy of the breast lump confirmed that it was an invasive carcinoma (Figure 1), the tissue was positive for hormonal estrogen and progesterone receptors (50%), HER-2 expression was complete and intense in 70% of neoplastic cells (3+), and Ki-67 expression was positive in 20% off cells (Figure 2). A bone scan indicated secondary bone lesions (sternum, left humeral head,
Bone scan before oral Cyclophosphamide and Methotrexate chemotherapy.
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In May 2008, the breast site had progressed, and a new lesion was detected on the skull (Figure 3).
Bone scan after 42 months of oral Cyclophosphamide and Methotrexate chemotherapy.
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The last bone scan showed a pathologic capitation only on the skull and sternum (Figure 4).