PMC7734869_01
Modified diisocyanate inhalation test protocol. Blue columns represent diisocyanate testing, red arrows mark the time points of lung function measurements. ppb = parts per billion.
allergologieselect-4-124-02.jpg
PMC7734869_01_allergologieselect-4-124-02.jpg
Figure2
Based on these findings, a modified short-term inhalation test with 3 ppb MDI over 1 minute was carried out in deviation from the standard exposure protocol (Figure 2).
Effect parameters before, 20 minutes, and 24 hours after inhalation testing. sRt = specific airway resistance; FEV1 = forced expiratory volume in 1 second; eNO = exhaled nitric oxide; ppb = parts per billion.
allergologieselect-4-124-03.jpg
PMC7734869_01_allergologieselect-4-124-03.jpg
Figure3
Examination of the sputum showed a percentage increase (from 23 to 31%) and an absolute increase (from 3.6 x 106 to 4.1 x 106) of eosinophilic granulocytes after the inhalation test (Figure 3).