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Histological evaluation of the patent's tumor. (A) Hematoxylin and eosin staining microphotograph. (B) Immunohistochemical staining for TTF-1 (SPT24). (C) Immunohistochemical staining for p40 (DeltaNp63). (D) FISH analysis for ALK-EML4 translocation.
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F1
ALK translocation was detected using FISH (Figure 1).
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PMC6803543_04
MRI evaluation of brain metastases dynamics at therapy lines 3 and 4 after development of the ceritinib resistance. Treatment regimens were pemetrexed + cisplatin (2015.04.03), topotecan followed by crizotinib (2015.07.20) and crizotinib + bevacizumab (2016.11.25). (A) Lesion 1, right temporoparietal region. (B) Lesion 2, right occipital lobe. (C) Lesion 3, right occipital lobe.
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F2
This resulted in a decrease of several brain lesions (Table 1, MRI 2016.08.04, 2016.10.24, and 2016.11.25; Figure 2, 2016.11.25).
PMC6803543_05
MRI evaluation of brain metastases dynamics at therapy lines 3 and 4 after development of the ceritinib resistance. Treatment regimens were pemetrexed + cisplatin (2015.04.03), topotecan followed by crizotinib (2015.07.20) and crizotinib + bevacizumab (2016.11.25). (A) Lesion 1, right temporoparietal region. (B) Lesion 2, right occipital lobe. (C) Lesion 3, right occipital lobe.
fonc-09-01026-g0002.jpg
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F2
This resulted in a decrease of several brain lesions (Table 1, MRI 2016.08.04, 2016.10.24, and 2016.11.25; Figure 2, 2016.11.25).
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PMC6803543_07