PMC6875174_01
Histopathological images of the bone marrow (magnification 10x). (a) Biopsy section obtained on October 2015 showing a hypocellular bone marrow with preserved megakaryopoiesis (hematoxylin and eosin stain). (c) Myeloperoxidase staining revealed adequate numbers of myeloid cells. (d) Glycophorin C staining revealed a virtually absent erythropoiesis. (e) Biopsy section obtained on March 2017 revealed a severe hypocellular marrow (<5%) (hematoxylin and eosin stain). (g) Myeloperoxidase staining revealed a virtually absent myelopoiesis. (h) Glycophorin C staining revealed a virtually absent erythropoiesis. (b and f) In both biopsies, immunohistochemical stain for CD3 revealed a modest lymphoid component with interstitial distribution (CD3+).
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fig1
A bone marrow aspirate and biopsy revealed a virtually absent erythropoiesis with a preserved granulocytic and megakaryocytic maturation without infiltration by thymocytes and CD1a + lymphocytes (Figure 1-2015). After 4 weeks, the patient presented a marked neutropenia, and a bone marrow biopsy showed a final evolution to AA (Figure 1-2017).