PMC3200069_01
Microphotographs showing (a) well-differentiated SCC with keratin pearl formation seen in Case 1 and (b) poorly differentiated squamous cell carcinoma seen in Case 3. The tumor is comprised predominantly of undifferentiated malignant tumor cells with islands of clearly squamous cells interspersed without keratinisation as seen in this picture; (c) moderately differentiated SCC in Case 4 showing solid sheets of tumor cells arising from the pelvis and infiltrating renal parenchyma. The urothelium lining the pelvis shows squamous metaplasia and dysplasia; (d) the same case showing tumor cells forming true papillae with fibrovascular cores seen in other areas; (e) all cases showed features of chronic pyelonephritis in the surrounding kidney as can be seen here in Case 3; (f) perineural invasion (arrow) of tumor cells seen in Case 2; (g) section from Case 1 with infiltration of the perirenal fat by the tumor cells.
ONCOLOGY2011-620574.003.jpg
PMC3200069_04_ONCOLOGY2011-620574.003.jpg
fig3
Histopathology of the lesion showed a moderately differentiated squamous cell carcinoma, with solid and focal papillary pattern (Figures 3(c) and 3(d)). The adjacent urothelium showed squamous metaplasia and dysplasia (Figure 3(c)).
PMC3200069_02
Gross photographs of operated kidney specimen showing (a) marked hydronephrosis, dilated pelvicalyceal system with markedly thinned out renal parenchyma seen in Case 2. An area of thickening is seen at the upper pole (white arrow); (b) replacement of the whole kidney by a solid grey-white tumor in Case 3. The tumor is limited to the kidney. In situ renal stones are identified (black arrow) and there are features of hydronephrosis.
ONCOLOGY2011-620574.002.jpg
PMC3200069_03_ONCOLOGY2011-620574.002.jpg
fig2
Surprisingly, nearly the whole kidney was replaced by a solid grey-white tumor, surrounding the dilated calyces, with a scant rim of renal parenchyma seen at the periphery (Figure 2(b)).
Microphotographs showing (a) well-differentiated SCC with keratin pearl formation seen in Case 1 and (b) poorly differentiated squamous cell carcinoma seen in Case 3. The tumor is comprised predominantly of undifferentiated malignant tumor cells with islands of clearly squamous cells interspersed without keratinisation as seen in this picture; (c) moderately differentiated SCC in Case 4 showing solid sheets of tumor cells arising from the pelvis and infiltrating renal parenchyma. The urothelium lining the pelvis shows squamous metaplasia and dysplasia; (d) the same case showing tumor cells forming true papillae with fibrovascular cores seen in other areas; (e) all cases showed features of chronic pyelonephritis in the surrounding kidney as can be seen here in Case 3; (f) perineural invasion (arrow) of tumor cells seen in Case 2; (g) section from Case 1 with infiltration of the perirenal fat by the tumor cells.
ONCOLOGY2011-620574.003.jpg
PMC3200069_04_ONCOLOGY2011-620574.003.jpg
fig3
Histopathology of the lesion showed a moderately differentiated squamous cell carcinoma, with solid and focal papillary pattern (Figures 3(c) and 3(d)). The adjacent urothelium showed squamous metaplasia and dysplasia (Figure 3(c)).
PMC3200069_03
Radiological images. (a) Plain X-ray (KUB) of Case 3 showing multiple radio-opaque shadows in the left kidney; (b) IVP skiagram of the same case at 15 min showing normal excretion of dye in the right kidney while there is complete absence of excretion in the left kidney. Dye excretion was not seen in the left kidney even up to 24 hours. Multiple renal stones can be seen in the left kidney similar to (a); (c) CT scan image of Case 4 showing small and irregular hydronephrotic right kidney with a nodule in the region of pelvis; (d) CECT image of Case 4 showing focal contrast enhancement in the nodule in pelvis.
ONCOLOGY2011-620574.001.jpg
PMC3200069_04_ONCOLOGY2011-620574.001.jpg
fig1
Contrast enhanced computerized tomography (CECT) scan showed small irregular hydronephrotic right kidney with a suspicious nodular lesion (Figures 1(c) and 1(d)).
Gross photographs of operated kidney specimen showing (a) marked hydronephrosis, dilated pelvicalyceal system with markedly thinned out renal parenchyma seen in Case 2. An area of thickening is seen at the upper pole (white arrow); (b) replacement of the whole kidney by a solid grey-white tumor in Case 3. The tumor is limited to the kidney. In situ renal stones are identified (black arrow) and there are features of hydronephrosis.
ONCOLOGY2011-620574.002.jpg
PMC3200069_03_ONCOLOGY2011-620574.002.jpg
fig2
Surprisingly, nearly the whole kidney was replaced by a solid grey-white tumor, surrounding the dilated calyces, with a scant rim of renal parenchyma seen at the periphery (Figure 2(b)).
Microphotographs showing (a) well-differentiated SCC with keratin pearl formation seen in Case 1 and (b) poorly differentiated squamous cell carcinoma seen in Case 3. The tumor is comprised predominantly of undifferentiated malignant tumor cells with islands of clearly squamous cells interspersed without keratinisation as seen in this picture; (c) moderately differentiated SCC in Case 4 showing solid sheets of tumor cells arising from the pelvis and infiltrating renal parenchyma. The urothelium lining the pelvis shows squamous metaplasia and dysplasia; (d) the same case showing tumor cells forming true papillae with fibrovascular cores seen in other areas; (e) all cases showed features of chronic pyelonephritis in the surrounding kidney as can be seen here in Case 3; (f) perineural invasion (arrow) of tumor cells seen in Case 2; (g) section from Case 1 with infiltration of the perirenal fat by the tumor cells.
ONCOLOGY2011-620574.003.jpg
PMC3200069_04_ONCOLOGY2011-620574.003.jpg
fig3
Histopathology of the lesion showed a moderately differentiated squamous cell carcinoma, with solid and focal papillary pattern (Figures 3(c) and 3(d)). The adjacent urothelium showed squamous metaplasia and dysplasia (Figure 3(c)).
PMC3200069_04
Radiological images. (a) Plain X-ray (KUB) of Case 3 showing multiple radio-opaque shadows in the left kidney; (b) IVP skiagram of the same case at 15 min showing normal excretion of dye in the right kidney while there is complete absence of excretion in the left kidney. Dye excretion was not seen in the left kidney even up to 24 hours. Multiple renal stones can be seen in the left kidney similar to (a); (c) CT scan image of Case 4 showing small and irregular hydronephrotic right kidney with a nodule in the region of pelvis; (d) CECT image of Case 4 showing focal contrast enhancement in the nodule in pelvis.
ONCOLOGY2011-620574.001.jpg
PMC3200069_04_ONCOLOGY2011-620574.001.jpg
fig1
Contrast enhanced computerized tomography (CECT) scan showed small irregular hydronephrotic right kidney with a suspicious nodular lesion (Figures 1(c) and 1(d)).
Microphotographs showing (a) well-differentiated SCC with keratin pearl formation seen in Case 1 and (b) poorly differentiated squamous cell carcinoma seen in Case 3. The tumor is comprised predominantly of undifferentiated malignant tumor cells with islands of clearly squamous cells interspersed without keratinisation as seen in this picture; (c) moderately differentiated SCC in Case 4 showing solid sheets of tumor cells arising from the pelvis and infiltrating renal parenchyma. The urothelium lining the pelvis shows squamous metaplasia and dysplasia; (d) the same case showing tumor cells forming true papillae with fibrovascular cores seen in other areas; (e) all cases showed features of chronic pyelonephritis in the surrounding kidney as can be seen here in Case 3; (f) perineural invasion (arrow) of tumor cells seen in Case 2; (g) section from Case 1 with infiltration of the perirenal fat by the tumor cells.
ONCOLOGY2011-620574.003.jpg
PMC3200069_04_ONCOLOGY2011-620574.003.jpg
fig3
Histopathology of the lesion showed a moderately differentiated squamous cell carcinoma, with solid and focal papillary pattern (Figures 3(c) and 3(d)). The adjacent urothelium showed squamous metaplasia and dysplasia (Figure 3(c)).