PMC3245497_01
Erythematous skin lesions, red-purple in color were located on the back, shoulders, the external surfaces of the arms, and on the anterior medial side of the thighs. Erythematous skin lesions, red-purple in color were located on the back, shoulders, the external surfaces of the arms, and on the anterior medial side of the thighs
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On the first week of admission, the skin lesions transformed into red-purple, firm and painful subcutaneous nodules (Figure 1).  These findings were consistent with the early lesions of fat necrosis of the newborn, and a skin biopsy was performed.
Focal nonspecific inflammation consisting of histiocytes and lymphocytes (a), eosinophilic crystals with radial extension in the necrotic fat cells (b)
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Pathological examination of the biopsy material obtained from the lesion border revealed a small number of lymphocytes and focal inflammatory areas consisting of histiocytes (Figure 2a). Additionally, there were radial eosinophilic crystals in the fat cells (Figure 2b).