PMC9715735_01
Timeline of clinical course before and after CO intoxication. PANSS, Positive and Negative Syndrome Scale; MINI, Mini-International Neuropsychiatric Interview; CGI-S, Clinical Global Impressions- Severity; CGI-I, Clinical Global Impressions-Improve.
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F1
In a clock-drawing test performed on the day of evaluation, he could not tell the hour hand from the minute hand and could not draw the hour hand (as dictated by a doctor; Figure 1). The treatment schedule is shown in Figure 1. In short, HBOT did not change his brain structure and function (Figure 2 and Table 1). Supplementary Figure 1 shows a change in scores on the Clinician-Rated Dimensions of Psychosis Symptom Severity (Dimensional) scale in the DSM-5, both the psychotic and cognitive symptoms.
Brain MRI T2 fluid-attenuated inversion recovery image. (A) Initially, it shows bilateral symmetric confluent high signal intensities in periventricular white matters of cerebral hemispheres, which are compatible with delayed CO encephalopathy. (B) After HBOT shows increases in the extent of confluent high signal intensities in bilateral cerebral periventricular and subcortical white matter. MRI, magnetic resonance imaging; CO, carbon monoxide; HBOT, hyperbaric oxygen therapy.
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F2
In short, HBOT did not change his brain structure and function (Figure 2 and Table 1).