PMC3861598_01
(A) Dark red maculopapules on the chest. (B) Multiple dark-red maculopapules on the lower extremities.
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A 35-year-old male presented to Cangzhou Central Hospital (Cangzhou, China) in September 2009 with multiple dark red maculopapules on the trunk and limbs (Fig. 1).
Hematoxylin-eosin stain of small, irregularly branched blood vessels proliferating throughout the dermis and embedded in a desmoplastic stroma at magnifications (A) x40 and (B) x200.
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The tumors were of the same histopathology and demonstrated proliferation of irregularly branched, thin-walled venules infiltrating the sclerotic dermal collagen and the presence of few blood vessels with inconspicuous lumina (Fig. 2A). A mixture of flat and plump endothelial cells was observed (Fig. 2B), however, there was an absence of cellular atypia and mitotic figures.
Endothelial cells of the proliferative vessels expressed (A) CD31, (B) CD34 and (C) factor VIII. (D) The pericytes expressed SMA and (E) HHF-35 (magnification, x400).
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Immunohistochemically, the endothelial cells of the proliferating vessels expressed CD31 (Fig. 3A), CD34 (Fig. 3B) and factor VIII (Fig. 3C). The pericytes expressed SMA (Fig. 3D) and HHF-35 (Fig. 3E).