PMC5971236_01
Axial MRI shows a 7.5 cm heterogenous mass in the right frontal lobe with T1-weighted sequences showing patchy enhancement following contrast administration (a) and hyperintensity with surrounding vasogenic edema on T2-weighted fluid attenuated inversion recovery sequences (b).
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However, magnetic resonance imaging (MRI) of the brain revealed a 7.5 cm heterogenous mass in the right frontal lobe (Figure 1) that showed patchy contrast enhancement, focal calcifications with blood products, and surrounding vasogenic edema with mild midline shift.
H&E stain shows a biphasic neoplasm characterized by dysplastic ganglion cells, including binucleate forms ((a) 400x magnification), and a hypercellular malignant glial component with nuclear atypia and increased mitotic activity ((b) 200x magnification).
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The ganglioglioma was qualified as anaplastic due to increased cellularity, nuclear atypia, and mitotic activity in the glial component (Figure 2).