PMC9126827_01
Representative HRCT of the chest before and after booster mRNA anti-COVID-19 vaccination. A) Comparison CT scan performed 18 months before anti-COVID-19 vaccination showing extended patchy areas of GGO along with traction bronchiectasis and bronchiolectasis in the lower lobes with left predominance suggestive for a fibrotic NSIP pattern. B) After the third dose of vaccination, chest HRCT revealed the presence of new areas of diffuse and severe GGO over-imposed on the NSIP pattern as for acute exacerbation.
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Chest X-ray showed a widespread reticulation with multiple small opacities in the lower lung zones. Chest high-resolution computed tomography (HRCT), confirmed the presence of ground-glass opacities (GGO) and areas of consolidations mainly in the lower lobes (Fig. 1).
A) Representative lung CT angiography images after booster mRNA anti-COVID-19 vaccination. Evidence of a hypodense embolic defect in an anterior segmental vessel of the right pulmonary artery is appreciable in the ipsilateral upper lobe, suggestive for pulmonary embolism, as shown in the mediastinal window with a 9 mm MIP (Maximum Intensity Projection) reconstruction. B) Contextual evidence of GGO alterations as for NSIP acute exacerbation is detectable in the lung window.
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Integrated CT-angiography revealed the concomitance of bilateral endoluminal thromboembolic defects at the segmentary/sub-segmentary level (Fig. 2).