PMC9660256_01
Kidney biopsy findings. (A-B) H&E and PAS staining show segmental sclerosis at the vascular pole of the glomerulus. The patient was diagnosed as having focal segmental glomerulosclerosis, perihilar variant. (A) H&E stain, x 400, (B) PAS stain, x 400). (C) Mild endocapillary hypercellularity and glomerular enlargement was observed in other glomeruli, with a maximum diameter of 302 mum. (PAS stain, x 250). (D) Electron microscopy showing mild effacement of foot processes. (EM, x 12,000).
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F1
In microscopic findings, glomerular size was mildly increased, and there was focal mild hypercellularity involving mesangial and endothelial cells (Figure 1).
Characteristics of the patient during the follow-up. This graph shows the patient's trend of proteinuria and creatinine-based estimated glomerular filtration rate (eGFR) and cystatin C levels during the follow-up. Proteinuria is indicated using a solid line, cystatin C using a dashed line, and creatinine-based eGFR using a double line. The patient's proteinuria and kidney function waxed and waned during the follow-up, and following the administration of losartan, his proteinuria and renal function improved and remains stationary. Creatinine based eGFR (ml/min/1.73 m2), Cystatin C (mg/L), Protein/Cr (mg/mg).
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F2
His proteinuria waxed and waned with his cardiac condition, and the dosage was adjusted according to the symptoms (up to 1.2 mg/kg) (Figure 2).