PMC4318821_01
High-resolution computed tomographic scan of the chest revealing multiple foci of ground glass opacities (blue arrows) and bilateral pulmonary nodular infiltrates (green arrows).
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Repeat HRCT showed development of new extensive bilateral pulmonary nodular infiltrates with ground glass opacities (Fig. 1).
Light microscopic findings of lung specimen (40x) stained with hematoxylin and eosin showing Aspergillus hyphae invading through the bronchial wall. A blood vessel is visible in the lower left field with an occluding thrombus and inflammatory cells in its lumen.
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Autopsy revealed Aspergillus hyphae invading through the bronchial mucosa, almost completely obliterating the lumen of mid- to small-sized bronchi (Fig. 2).
Hematoxylin and eosin stain of the lung specimen under a light microscope at 200x showing typical branching, septate Aspergillus hyphae, invading through the mucosa of a distal bronchi.
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Aspergillus was also evident with concomitant widespread pulmonary arterial thrombi (Fig. 3). Acute tubular necrosis in the kidneys and centrilobular liver necrosis were also reported.