PMC3354388_01
Benign epidermal inclusion cyst filled with laminated keratin (hematoxylin and eosin, original magnification x100).
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F1
Histological examination of the specimen showed a cystic lesion lined by bland squamous epithelium and filled with laminated keratin (Fig. 1).
Malignant squamous cell carcinoma arising from the epidermal cyst; with mitotic activity and cellular atypia (hematoxylin and eosin, original magnification x400).
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F2
These areas of typical epidermal cyst were juxtaposed with zones that displayed marked nuclear irregularity with mitotic activity and an infiltrative growth pattern (Fig. 2).
Immunohistochemistry showing positivity of the tumor cells for P53 protein (original magnification x200).
NAJMS-2-46-g003.jpg
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F3
Immunohistochemical detection of p53 antigen was found only in cell squamous carcinoma (Fig. 3).