PMC10357379_01
Longitudinal dynamics of inflammatory protein biomarkers levels measured from plasma in Case 1 at hospital days 0, 4, 7, and 14. The box plots represent control values from convalescent plasma samples collected from non-MIS-A control patients 3 months following COVID-19 diagnosis.
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fig2
Compared to post-COVID-19 convalescent controls (Supplementary Table S2), we observed elevations in IL-8, IL-10, IP-10, IL-18, TNFR-1, Ang2, ICAM-1, SP-D, and MMP-8, which peaked by hospital day 7 and then normalized (Figure 2).
PMC10357379_02
PMC10357379_03
Histological images from endomyocardial biopsy of Case 3. Sections show acute myocarditis with focal myocyte damage associated with mixed inflammatory cell infiltrates containing abundant eosinophils and histiocytes along with a mixture of lymphocytes, plasma cells and occasional neutrophils. The inflammation is particularly prominent in a perivascular and endocardial pattern with extension into the interstitial space.
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Histopathology from a myocardial biopsy suggested acute myocarditis (Figure 3).