PMC4899670_01
33-year-old male with thalassemia intermedia. AP and lateral lumbar radiographs show severe osteopenia, hepatosplenomegaly, and T12 compression fracture.
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Lumbar radiographs demonstrated severe osteopenia, hepatomegaly, splenomegaly, and a wedge-compression fracture of the T12 vertebral body (Fig. 1).
33-year-old male with thalassemia intermedia. Sagittal T1- and T2-weighted images show T12 compression fracture and diffusely hypointense marrow.
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MRI demonstrated diffusely hypointense bone marrow on the T1- and T2-weighted images, consistent with red-marrow activation secondary to anemia and iron deposition (Fig. 2).
33-year-old male with thalassemia intermedia. T1-weighted coronal image shows markedly enlarged, hypointense liver and splenomegaly.
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An enlarged, diffusely hypointense liver was seen on the T1-weighted images, consistent with iron deposition (Fig. 3).