PMC4672079_01
SDPR expression for various hematopoietic cells. Each dot in the plot corresponds to the expression of SDPR in a microarray. Horizontal lines represent the median expression for each class of cells. Expression is given on y-axis on a log2 scale. HSC_BM, Hematopoietic stem cells from bone marrow; early HPC_BM, Hematopoietic progenitor cells from bone marrow; CMP, Common myeloid progenitor cell; GMP, Granulocyte monocyte progenitors; MEP, Megakaryocyte-erythroid progenitor cell; PM_BM, Promyelocyte from bone marrow; MY_BM, Myelocyte from bone marrow; PMN_BM, Polymorphonuclear cells from bone marrow; PMN_PB, Polymorphonuclear cells from peripheral blood; CD14+ monocytes, CD14+ Monocytes; B cells, CD19+ B cells; CD4+ T cells, CD4+ T cells; CD8+ T cells, CD8+ T cells; NK cells, CD56+ natural killer cells; mDC, CD11c+ myeloid dendritic cells; pDC, CD123+ plasmacytoid dendritic cells.
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Given that SDPR is highly expressed in hematopoietic early progenitor cells (Fig. 1), we hypothesized that the fusion of the SDPR promoter to the PDGFRB coding region would result in overexpression of PDGFRB as has been reported with other fusions.