PMC6636556_01
(a) Frontal view of the large protruding tumor, located on the anterior chest wall, measuring 4 x 3 cm at the first visit. (b, c) Axial (b) and sagittal (c) view of the tumor (arrow) on T2-weighted magnetic resonance imaging.
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On examination, a protruding lesion was noted on the left chest wall, measuring approximately 4 x 3 cm in size (Figure 1(a)). Magnetic resonance imaging revealed a tumor measuring 4 x 3 x 3 cm, protruding subcutaneously superior to the clavicle (Figures 1(b) and 1(c)).
(a) The mass comprising fibromyxoid tissue with focal spindle cell proliferation and inflammation in a loosely myxoedematous matrix with extravasated red blood cells on hematoxylin and eosin (HE) staining. (b) Fluorescence in situ hybridization (FISH) analysis showing USP6 gene break-apart signals. (c) The tumor with necrosis that spontaneously separated and fell off (measuring 6.5 x 5.3 x 3 cm).
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Histopathological examination following hematoxylin and eosin staining of the needle biopsy specimen revealed that the mass comprised fibromyxoid tissue with focal spindle cell proliferation and inflammation in a loosely myxoedematous matrix with extravasated red blood cells (Figure 2(a)). Apart Probe was performed. FISH analysis revealed many USP6 rearrangements by splitting of the red and green signals in both nuclei in this field, strongly suggesting a diagnosis of NF (Figure 2(b)). Although the histopathological results did not match the clinical course, such as extremely rapid growth, he was followed up without treatment. One month later, the tumor spontaneously separated and fell off (Figure 2(c)).
(a) Frontal view of the enlarging tumor with bleeding during the operation. (b) Wide excised specimen of the tumor, measuring approximately 5.5 x 4.5 x 3 cm.
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Following this, the remaining tumor on the chest wall continued to grow rapidly (Figure 3(a)). The resected tumor measured approximately 5.5 x 4.5 x 3 cm (Figure 3(b)).