PMC5340656_01
Histopathology of renal biopsy demonstrating acute tubulointerstitial nephritis with some chronicity. (A) Glomerulus showing ischemic change and periglomerular fibrosis. Hematoxylin & eosin (H&E) stain, 200x. (B) Lymphocytic tubulitis, 500x, Periodic acid-Schiff stain. (C) Interstitial inflammation in the medulla, predominantly chronic, with interstitial fibrosis, tubular atrophy, and regeneration. H&E stain, 200x. (D) Interstitial fibrosis highlighted with Masson-trichrome stain, 200x. Sclerotic collagen is highlighted in blue.
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F1
TIN and some interstitial fibrosis (Figure 1). The patient was treated with prednisone (60 mg daily) for TIN with improvement of creatinine to 1.0 mg/dL.
Histopathology of lower GI biopsies demonstrating Crohn's disease. (A) Terminal ileum showing mild active ileitis, with lymphocytic and neutrophilic infiltration into glands and mild architectural distortion. H&E stain, 50x. (B) Chronic active colitis with granuloma formation (arrow) in the ascending colon. H&E stain, 200x. (C, D) Descending colon with chronic active colitis with crypt abscess (arrow) formation (C) and cryptitis (D). H&E stain, 200x.
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F2
Colonoscopy confirmed ileocolonic CD (Figure 2).