PMC4434159_01
A) Mid-power view showing the mainly papillary architecture of this primary peritoneal mesothelioma. Note the proliferation of malignant epithelioid type mesothelial cells. Hematoxylin -eosin (H&E) stain. Original magnification 100x. B) Higher power view of the tumor showing the classic malignant mesothelial cell features. H&E stain. Original magnification 400 x. Supporting the diagnosis of malignant mesothelioma: C) strong calretinin positivity. Original magnification 100 x. D) Strong D2-40 positivity. Original magnification 100 x. E) Strong CK5/6 positivity. Original magnification 200 x.
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These cells were positive for calretinin found in both benign mesothelial cells and mesothelioma (Fig. 1A-B). CK5/6, calretinin and WT-1 are used collectively for mesothelioma (Fig. 1C-E).