PMC6684484_01
Bone marrow examination at diagnosis.
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Auer rods, and strong myeloperoxidase (Figure 1). All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) were administered immediately after APL was suspected.
Chromosome karyotype analysis at first diagnosis: 45, X, -X [16].
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CD13, CD33, CD117, and CD64, and was negative for HLA-DR and CD34, CD3, CD4, CD56, CD5, CD10, CD19, CD20, CD7, CD11b, CD16, CD15, CD14, CD36, CD41, and CD71. Chromosomal examination of leukemia cells revealed the karyotype 45, X, -X (Figure 2).
Chromosome karyotype analysis at relapse: 45, X, -X [8]/45, idem, t(9; 12) (q13; p11) [12].
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Cytogenetics revealed 45, X, -X [8]/45, idem, t(9;12)(q13;p11) [12], which differed from that during the initial diagnosis (Figure 3).