PMC3638573_01
X-ray (one day after inpatient admittance) and CT scan of the chest (one month prior to first chemotherapy administration). Normal finding in both lungs.
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fig1
At that time the conventional chest X-ray and the previous computerised tomography of the chest (obtained one month prior to the initiation of chemotherapy) were inconspicuous (Figure 1).
X-ray (seven days after inpatient admittance) and CT scan of the chest (five days after initiation of chemotherapeutic treatment). Patchy airspace consolidation with peribronchial and peripheral distribution. Small pleural effusion bilaterally (black asterisk).
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fig2
During the course of treatment, both the conventional X-ray and the CT scan of the chest revealed bilateral patchy consolidations of both lungs and low-grade pleural effusions (Figure 2).
Lung biopsy specimen obtained by video-assisted thoracoscopic wedge resection (HE x10). Extensive granulomatous inflammation. No evidence of fibrosis or malignancy.
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fig3
The histological findings revealed extensive granulomatous inflammation with no evidence of malignancy (Figure 3).
CT scan of the chest five months after the first application of chemotherapy. Small scar in the right upper lobe (white arrow) and small pleural calcification (white arrowhead) as residual lesions of the inflammatory process.
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fig4
A CT scan of the chest 5 months after respiratory failure (Figure 4) showed virtually complete resolution with only slight residual subpleural scarring and pleural calcifications.