PMC10354642_01
MRI of the patient's liver (A). T1WI showed the presence of clumpy and other low-confounding signal shadows in the right lobe of the liver (B). Most of the lesion site on T2WI had slightly higher signal shadows, with irregular bars of low signal shadows inside (C). On DWI, the lesion site was unevenly hyperintense (D). Contrast-enhanced MRI showed that the edge of the arterial lesion was strengthened, with significant punctate strengthening, and large areas of low intensity were seen in the lesion (E, F). The lesion site in the portal phase and delayed phase had a clear marginal contour and mild internal delayed intensification. MRI, magnetic resonance imaging; T1WI, T1 weighted image; T2WI, T2 weighted image; DWI, diffusion weighted imaging.
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F1
Conventional and contrast-enhanced MRI showed a 20 cm diameter mass in the right posterior lobe of the liver (Figure 1).
Pathological characteristics of the tumor. H&E stained image showing that the tumor contained a mixture of proliferative spindle cells and a large number of small lymphocytes and plasma cells. Hematoxylin and eosin stain, original magnification 200X (A) and 400X (B). Immunohistochemistry showed that the neoplastic cells were strongly positive for CD23 (C) and EBER staining (D). Magnification 200X (C) and 400X (D). In CD3 (E) and CD20 (F) staining, the oval tumor cells were negative, and there were positive T cells and B cells infiltrated in the background.Magnification 400X (E) and 400X (F). H&E, hematoxylin and eosin;EBER, Epstein-Barr virus-encoded RNA.
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F2
Pathological analysis of surgical specimens showed that the tumor was composed of proliferating spindle cells arranged in an interlaced manner, with weakly acidophilic cytoplasm, oval nuclei, flocculent or fine-grained chromatin, small and clear nucleoli, and increased plasma in the background (Figure 2). In situ hybridization showed EBER positivity (Figure 2).