PMC10228719_01
(A) Fiberoptic bronchoscopy shows cauliflower-like new organisms blocking the left main bronchus and oozing blood on the surface of the new organisms. The pathological classification of lung squamous cell carcinoma was confirmed by multi-biomarker immunohistochemistry. (B) HEx100, (C) HEx400, (D) ki-67, (E) P40, (F) TTF-1.
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This location was the site of the biopsy, which revealed lung squamous cell carcinoma ( Figure 1A ). TTF-1 (-) ( Figures 1B-F ) in immunohistochemistry. The patient ceased chemotherapy because he could not endure the adverse effects of nausea and vomiting after one cycle of perfusion chemotherapy (40 mg nedaplatin via bronchial artery infusion administration) and paclitaxel systemic intravenous treatment.
The clinical course schedule of this patient includes the treatment plan received by the patient and the chest CT of the disease response on each treatment route.
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The therapy options, disease response, and PFS for each treatment line are summarized in  Figure 2 .