PMC8415261_01
Nomograph of predicted tacrolimus plasma concentrations corrected for hematocrit. (A) Schijvens' nomograph (B) Use of the Schijvens' nomograph to convert the measured TWBC (5.4 microg/l with 24.6% Hct) on day 24 to [B(i)] predicted tacrolimus plasma concentration and [B(ii)] predicted TWBC for 40% Hc.
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F1
Because of a persistent anemia with an Hct value of less than 25%, the nomograph of "predicted tacrolimus plasma concentrations corrected for Hct" published by, which described the relationship between TWBC and plasma tacrolimus concentrations for different Hct levels, was used to correct the TWBC (see Figure 1A). TWBC for 40% Hct revealed supratherapeutic concentrations (15 microg/l) on day 17 and 18 as well as high concentrations (11.5 microg/l) on day 22 and 23. Tacrolimus plasma concentrations were measured on day 24 by LC/MS and compared to the tacrolimus plasma concentrations predicted by the nomograph to assess the method's accuracy (Figure 1B).