PMC3187931_01
Formalin-fixed paraffin-embedded (FF-PE) samples of CT-guided fine needle aspiration of both the right (A) and the left (B) nodule (Hematoxylin and eosin stain, 40X.)
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F1
In both cases the cytological analysis (Fig. 1) was consistent with adenocarcinoma, displaying a TTF-1 and p63 positive immunohistochemical profile.
Evolution of tumor lesions after 6 months therapy with erlotinib as documented by CT scan. Panel A: thoracic CT scan, after chemotherapy. Panel B: thoracic CT scan after 6 months of therapy with erlotinib, 150 mg/die.
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F2
After 6 months of treatment the EGFR mutated lesion displayed a volume reduction of more than 50%; the controlateral nodule showed a less but still significant (15 %) reduction in both diameter and density (Fig.2).