PMC10405930_01
High uptake of 18F-FDG in the known lesions with increasing radioactivity uptake of 18F-FDG PET/CT in September 2022. (A) The hepatopancreatic lesions (SUVmax = 19.8). (B) The dilatation of the distal main pancreatic duct and the intrahepatic bile duct system. (C) The breast lesion (SUVmax = 12.9). (D) Multiple axillary lymph nodes lesions (SUVmax = 10.4).
fonc-13-1204041-g001.jpg
PMC10405930_01_fonc-13-1204041-g001.jpg
f1
High uptake of 18F-FDG was noted within the known lesions in the hepatopancreatic lesions with increasing radioactivity uptake ( Figure 1A ), which was new and increased in scope from March 2017. All of these were considered malignant, and metastatic tumors led to dilatation of the distal main pancreatic duct and the intrahepatic bile duct system ( Figure 1B ). An avid enhancing soft tissue density lesion with the size of approximately 5.3 * 4.3 cm was noted incidentally in the left breast, showing an uneven increase in radioactive uptake (SUVmax = 12.9) ( Figure 1C ). Multiple lymph nodes with increased radioactive uptake were observed in the left axillary region ( Figure 1D ). 18F-FDG PET/CT suggested that further pathological examination is warranted for breast lesions with high FDG uptake. In addition, there were some enhanced nodules in the right breast (BI-RADS 4A) ( Supplementary Figure S1 ).
H&E(100x &400x) and IHC(200x) staining of the breast tissue in September 2022.
fonc-13-1204041-g002.jpg
PMC10405930_01_fonc-13-1204041-g002.jpg
f2
The pathological results ( Figure 2 ) were as follows: hematoxylin and eosin (H&E) staining revealed a histological pattern of adenocarcinoma.