PMC5836207_01
Endoscopic image of a granular cell tumor located on the cecal valve (black arrow).
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F1
Two 9-mm sessile polyps were identified on the ileocecal valve (Fig. 1), which were resected with a hot snare.
Histopathologic images of a granular cell tumor by hematoxylin and eosin staining that is primarily submucosal with some focal mucosal extension (a). It is composed of compact nests of epithelioid cells with oval nuclei including abundant, granular cytoplasm with spindling and moderate nuclear pleomorphism. Mitotic figures are not identified (b). A small cauterized fragment of a tubular adenoma is overlying the granular cell tumor (c), with unknown clinical significance.
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F2
Periodic acid-Schiff staining with and without diastase was positive along with a tubular adenoma in the overlying mucosa (Fig. 2c).
Immunohistologic staining positive for S100, CD68, and inhibin alpha. The Ki-67 index was 2-3%. This immunophenotype is in accordance with the histopathologic findings and is consistent with granular cell tumor with atypical features.
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F3
Immunohistochemical staining was positive for S100, CD68, and inhibin alpha and with a Ki-67 proliferative index of 2-3% (Fig. 3).