PMC6511651_01
Fundus photographs and B-scan OCT images of the left eye in case 1. Images were obtained at the first examination (4 days after the onset) (A), and then at 1 month (B), 6 months (C), 4 years (D), and 5 years (E). (A) Fundus photograph shows a small dark gray lesion supero-nasal to the fovea. OCT shows a hyperreflective band ranging from the inner plexiform layer to the OPL, which corresponded to the fundus lesion. (B) Fundus photograph shows there was a gradual disappearance of the lesion. OCT showed that the hyperreflective band was limited to the thinned inner nuclear layer. (C) OCT revealed there was a thin and irregular inner nuclear layer and OPL with the hyperreflective change no longer present. (D and E) Additional OCT images show the presence of focal serous retinal detachment, with an excavated change of the inner retinal surface and thickening of the outer nuclear layer.. Abbreviations: OCT, optical coherence tomography; OPL, outer plexiform layer.
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Funduscopy showed a small dark gray lesion supero-nasal to the fovea in the left eye (Figure 1A). B-scan OCT (Cirrus HD-OCT; Carl Zeiss Meditec AG, Dublin, CA, USA) showed a hyperreflective band ranging from the inner plexiform layer (IPL) to the outer plexiform layer (OPL), which corresponded to the fundus lesion (Figure 1A). The patient was followed-up at 1 month (Figure 1B), 6 months (Figure 1C), 4 years (Figure 1D) and 5 years (Figure 1E) after the onset.
OCTA images during the chronic phase in cases 1 and 2. The OCTA images were obtained at 5 years after the onset in case 1 (A) and at 2.5 years after the onset in case 2 (B). The left column shows the superficial capillary plexus (SCP) images while the right column shows the DCP images. OCTA images of both cases revealed there was normal flow of the macular capillaries in the SCP, and a decreased flow in the PAMM lesion, with dilation of the capillaries (yellow arrows) around the lesion in the DCP.. Abbreviations: OCTA, optical coherence tomography angiography; SCP, superficial capillary plexus; DCP, deep capillary plexus; PAMM, paracentral acute middle maculopathy.
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At 2.5 years after onset, OCTA images showed there was a normal flow of the macular capillaries in the SCP, and a decreased flow in the lesion, with dilation of the capillaries around the lesion observed in the DCP (Figure 2B).
PMC6511651_02
OCTA images during the chronic phase in cases 1 and 2. The OCTA images were obtained at 5 years after the onset in case 1 (A) and at 2.5 years after the onset in case 2 (B). The left column shows the superficial capillary plexus (SCP) images while the right column shows the DCP images. OCTA images of both cases revealed there was normal flow of the macular capillaries in the SCP, and a decreased flow in the PAMM lesion, with dilation of the capillaries (yellow arrows) around the lesion in the DCP.. Abbreviations: OCTA, optical coherence tomography angiography; SCP, superficial capillary plexus; DCP, deep capillary plexus; PAMM, paracentral acute middle maculopathy.
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At 2.5 years after onset, OCTA images showed there was a normal flow of the macular capillaries in the SCP, and a decreased flow in the lesion, with dilation of the capillaries around the lesion observed in the DCP (Figure 2B).
Fundus photographs and OCT B-scan images of the right eye in case 2. The images were obtained at the first examination (5 days after the onset) (A), and at 3 weeks (B), 4 months (C), 1.5 years (D), and 2.5 years (E). (A) Fundus photograph shows a small dark gray lesion just superior to the fovea. OCT shows a hyperreflective band that ranges from the inner plexiform layer to the OPL, and which corresponded to the fundus lesion. (B) Funduscopy shows there was a gradual disappearance of the lesion. OCT revealed that the hyperreflective band was limited to the INL with slight thinning. (C) OCT also showed there was a thin and irregular INL and OPL that no longer exhibited a hyperreflective change, an excavated change of the inner retinal surface (arrow), and thickening of the outer nuclear layer. (D and E) The images remain unchanged.. Abbreviations: OCT, optical coherence tomography; OPL, outer plexiform layer; INL, inner nuclear layer.
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Funduscopy showed there was a small dark gray lesion just superior to the fovea in his right eye (Figure 3A). B-scan OCT showed a hyperreflective band ranging from the IPL to OPL, which corresponded to the fundus lesion (Figure 3A). The patient was subsequently followed-up at 3 weeks (Figure 3B), 4 months (Figure 3C), 1.5 years (Figure 3D) and 2.5 years (Figure 3E) after the onset.