PMC3814281_01
Tumour biopsy showing poorly differentiated cells with scarce cytoplasm and vesicular nuclei with inconspicuous nucleoli. High mitotic index and apoptotic figures were present. Immunohistochemical reactions were positive for cytokeratin 8 and 20 and neuroendocrine markers (chromogranin, synaptophysin and CD56/NCAM); TTF-1 was not expressed (H&E stain, 40x).
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A diagnosis of MCC was established (Figure 1).
Before first electrochemotherapy: voluminous bluish lesion of the chin.
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A biopsy of the mass confirmed recurrent MCC (Figure 2).
Reduction of 80% of the volume to the initial lesion after 2 treatments.
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The next ECT treatment resulted in 80% volume reduction compared to the original lesion (Figure 3).
Follow up after four electrochemotherapy applications and 16 months.
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