PMC6629187_01
DNA sequencing of the PRNP gene.. Compared with the standard sequence, the substitution of cytosine with adenine at codon 196 of the PRNP gene results in the substitution of alanine for glutamate (E196A). The PRNP polymorphism of codon 129 was 129M/M homozygous.
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F0001
As compared to the standard PRNP sequence (NCBI: NM183079.1), the sequence analysis of the PRNP gene in the current patient showed a missense mutation occurring at codon 196 (E196A: GAG-GCG) (Figure 1).
Results of DWI scans.. a  and b  show an increase in signal intensity changes at the surface of the temporal lobe and bilateral basal ganglia regions (especially the caudate nucleus). c  and d  show ribbon-like signals in the right parietal lobe.
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F0002
In the current case, the diffusion-weighted magnetic resonance imaging (DWI/MRI) showed an increase in signal intensity changes at the surfaces of the right temporal and parietal lobes, left parietal lobe, and the bilateral basal ganglia region (Figure 2).
Results of the second EEG.. The second EEG was performed at 2 months after onset of the movement disorder, and a week after the first EEG. The results of the two EEG examinations were similar. a  demonstrates abnormal waves in the background. b  displays sharp waves, sharp slow waves, and slow waves that are discharged synchronously or asynchronously at the bilateral occipital and frontal region.
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F0003
Electroencephalography (EEG) was performed twice, but no typical periodic sharp wave complexes (PSWCs) were observed (Figure 3).