PMC3986535_01
The histologic section of the parotid gland tumor shows a malignant proliferation of a duct, resembling ductal carcinoma in situ of the breast. There is a cribriform architecture with central necrosis (arrow). The cells have prominent nucleoli with apocrine type cytoplasm (H and E, x10 Obj)
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F1
He was originally diagnosed at age 67 with a 1.5 cm right submandibular SDC, which showed large polygonal epithelioid cells with prominent nucleoli and abundant granular eosinophilic cytoplasm, arranged in a cribriform pattern with central necrosis [Figure 1].
Composite photograph of the pleural fluid shows smears and cell block. The smear shows a single cluster of epithelioid cells with prominent nucleoli and apocrine cytoplasm (Papanicolaou stain, x40 Obj). A subtle cribriforming feature is noted (arrow). The inset is a photomicrograph of the cell block showing a cluster of malignant epithelioid cells making a lumen (H and E, x60 Obj)
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F2
Cytological evaluation of cytospin preparations and cell block revealed large, pleomorphic epithelioid cells in small clusters with subtle cribriform features [Figure 2].
Composite photograph of the immunohistochemical stains performed on the cell block. Panel A is a photomicrograph of androgen receptor showing positive nuclear staining of the malignant cells. Panel B shows human epidermal growth factor receptor-2/neu staining cell membrane of the malignant cells. Panel C illustrates cell membrane and cytoplasmic staining of these cells with MOC-31. Panel D shows cytoplasmic staining of this cluster with gross cystic disease fluid protein-15 (x60 Obj)
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F3
Immunohistochemical stains [Figure 3] performed on the cell block were positive for androgen receptor (AR) (panel A), HER2/neu (panel B), Moc31 (panel C) and GCDFP-15 (panel D).