PMC5299147_01
(a, b) Preoperative T1 magnetic resonance (MR) images demonstrates expansive changed and elongated right optic nerve. (c) Preoperative coronal plane T1 gadolinium-enhanced MR image. (d) Preoperative sagittal plane T2 MR image
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F1
MRI of the brain and orbits showed expansive changed and elongated right optic nerve with contrast enhancement; furthermore, a smaller lesion in the right temporal operculum region was visible in T2 and fluid-attenuated inversion recovery sequence, as well as a small oval lesion in the left cerebellar lobe [Figures 1 and 2].
(a, b) Preoperative magnetic resonance imaging showing left cerebellar and right temporal intracranial lesions
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F2
MRI of the brain and orbits showed expansive changed and elongated right optic nerve with contrast enhancement; furthermore, a smaller lesion in the right temporal operculum region was visible in T2 and fluid-attenuated inversion recovery sequence, as well as a small oval lesion in the left cerebellar lobe [Figures 1 and 2].
(a, b) Postoperative T2 images, axial and coronal plane. (c) Postoperative T1 axial plane image
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F3
After 3 years of follow-up, MRI showed complete tumor removal without any sign of recurrence [Figure 3].
(a) Microscopic features; mainly histiocytes and a few chronic inflammatory cells in fibrous background (hematoxylin and eosin x100). (b) Emperipolesis; an additional common histopathologic finding in Rosai-Dorfmann disease (hematoxylin and eosin x400)
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F4
The phenotype was consistent with RDD [Figures 4 and 5].
Immunohistochemistry: (a) Glial fibrillary acidic protein small fragments of brain tissue were positive whereas tumour was negative (x100). (b) CD68 positive histiocytic tumor cells (x400); (c) negative staining for CD1a (x100)
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F5
The phenotype was consistent with RDD [Figures 4 and 5].