PMC9666705_01
HE stained sample of the papillary thyroid carcinoma.
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Fine needle aspiration (FNA) biopsy confirmed metastatic papillary thyroid carcinoma with involvement of cervical lymph nodes (Figure 1).
HE stained sample at low (a) and high (b) power magnification showing direct invasion of PTC (vertical arrow) into perithyroidal soft tissue and parathyroid tissue (horizontal arrow), with no demonstrable capsule and background thyroid tissue with Hashimoto's thyroiditis (a, star).
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Final pathology confirmed a 45 mm low grade conventional type papillary carcinoma in the left thyroid lobe with microscopic extension into perithyroidal soft tissue focally and into the adjacent left parathyroid gland (Figures 2 and 3). The background thyroid parenchyma showed features suggestive of Hashimoto's thyroiditis (Figure 2(a)).
GATA-3 positive stained parathyroid tissue (long arrow) demonstrating direct invasion of PTC (short arrow) into parathyroid tissue that has no evidence of a capsule.
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Final pathology confirmed a 45 mm low grade conventional type papillary carcinoma in the left thyroid lobe with microscopic extension into perithyroidal soft tissue focally and into the adjacent left parathyroid gland (Figures 2 and 3).
PTC cells showing cystoplasmic positivity for BRAFV600E mutation on both the right (a) and left (b) side.
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Immunohistochemistry was positive for BRAFv600E (Figure 4).