PMC10098200_01
Preoperative computed tomography (CT) scans. (A) Markedly enlarged prostate with irregular morphology, measuring approximately 58x93x106mm, with an indistinct border with the rectum. (B) Indistinct demarcation of the prostate from the posterior bladder wall. The red arrow indicates the site of the lesion.
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The local border between the prostate and the posterior wall of the bladder was poorly delineated ( Figures 1A, B ).
The hematoxylin-eosin (HE) and immunohistochemical pictures. (A) The tumor cells are uniform in size, round in shape, well-defined, and distributed around blood vessels (HE, original magnification, 100x). (B) The tumor cells show diffuse heterogeneous proliferation, increased mitotic signs, and visible multifocal necrosis (HE, original magnification, 200x). Immunohistochemistry: SMA (C), Vimentin (D), Desmin (E), TFE3 (F), and HMB45 (G).
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Tumor cells showed diffuse atypia with increased mitotic activity and multifocal necrosis under high power field ( Figures 2A, B ). TFE3, and desmin ( Figures 2C-G ). These findings were highly suggestive of a malignant glomus tumor.
Treatment timeline of the malignant glomus tumor case.
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The treatment timeline for this patient is summarized in  Figure 3 .