PMC9065553_01
The detailed information of chemotherapy and MRD; VDLP: vindesine (VDS), daunorubicin (DNR), l-asparaginase, and prednisone; CAM: cyclophosphamide (CTX), cytarabine (Ara-C), and mercaptopurine (6-MP). HD-MTX: high dose of methotrexate; HF: heart failure; HT: heart transplantation. The purple boxes revealed daunorubicin infusion dosages from Day 1 (D1) to Day 3 (D3).
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F1
The detailed information of chemical drugs and minimal residual disease (MRD) are showed in Figure 1. DNR was administrated three consecutive daily doses every 3 weeks and the infusion dosage each day is presented in Figure 1.
The changes of shortening fraction (SF), serum pro B type natriuretic peptide (Pro-BNP), creatine kinase (CK-MB), and cardiac troponin I (cTnI) after the outset of chemotherapy.
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F2
I (cTnI) were also routinely monitored and are shown in Figure 2. In May 2018, he received cardiac transplantation in our hospital.
(A,B) The structural changes of this transplant recipient's myocardium, being magnified respectivelyx100 and x400 by light microscope. The myocardium of the specimen from the heart transplant recipient revealed hypertrophy of cardiomyocytes with disordered arrangement; segmental vacuolar degeneration; and myocardial fibers blurring. (C,D) The histopathological characteristics of the biopsy tissue from retroauricular lymph nodes on the left side, being magnified respectivelyx100 and x400 by light microscope. The images show groups of lymphoma cells compartmentalized by fine fibrosis, large and arranged neoplasm in a diffuse pattern that partially effaces normal nodal architecture, and areas of geographic necrosis. The lymphoma cells are moderately large in size with an abundant amount of cytoplasm, most of which is without nucleoli.
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F3
The pathology of myocardial tissue suggested dilated cardiomyopathy seen in Figures 3A,B. The biopsy confirmed monomorphic diffused large B cell lymphoma (DLBCL) associated with Epstein-Barr virus (EBV) as shown in Figures 3C,D.