PMC5259934_01
(a) Smears:plenty of plump spindle cells with abundant eosinophilic cytoplasm (H&E, x40). Inset:cells with bipolar cytoplasmic extensions and fine nuclear chromatin (Pap, x100) (b) Smears : collagenous matrix and small cells with scant cytoplasm (H&E, x40) (c) Histopathology : dermal tumor comprising of spindle cells with areas of hyalinization (H&E, x40). Inset:multiple subcutaneous swellings in the cervical region (d) Histopathology:small cells arranged around thin blood vessels (H&E, x40). Inset:immunohistochemistry-vimentin positivity
JCytol-34-53-g001.jpg
PMC5259934_01_JCytol-34-53-g001.jpg
F1
On examination, the patient had total seven subcutaneous, nontender, mobile swellings ranging in size from 1 cm x 1 cm to 3 cm x 3 cm in both cervical [Figure 1c, inset], right paraspinal regions and the anterior abdominal wall. Predominantly, spindle cells with eosinophilic cytoplasm [Figure 1a], collagenous matrix, and a few small cells with scanty cytoplasm were observed [Figure 1b]. Isolated plump spindle cells showed bipolar cytoplasmic extensions and round-to-oval nuclei with fine granular chromatin without prominent nucleoli [Figure 1a, inset]. The sections revealed intact epidermis and the dermis showed the presence of a tumor mass that comprised of spindle cells arranged in a haphazard manner with areas of hyalinization [Figure 1c]. The central tumor area showed small cells with scanty cytoplasm arranged around thin-walled blood vessels [Figure 1d]. Immunohistochemistry revealed positivity for actin, vimentin [Figure 1d, inset] and desmin negativity.