PMC2929522_01
Macrophotograph showing solid tumoral lesion in subepidermal area. A slice of the lesion contained some regions of bleeding.
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fig1
A slice of the lesion contained some regions of bleeding (Figure 1). 
Histological microphotograph showing neoplastic cells with prominent nucleoli and moderate plemorphism beneath the squamous epithelium (H&E; (a) x100; (b) x200; (c) x400).
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fig2
The lesion was localized predominantly in the dermis, beneath hyperkeratotic epidermis, and pressing on subcutaneous fatty tissue (Figure 2(a)). The tumor cells had translucent cytoplasm, prominent cytoplasmic membranes, and round-to-ovoid nuclei (Figure 2(b)). Pleomorphisms in the tumor cell nuclei and eosinophilic nucleoli were apparent (Figure 2(c)).
Renal cell carcinoma marker and vimentine immunoreactions in neoplastic tumor cells (ABC-DAB; (a, b) x200).
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fig3
The tumor cells reacted positively with RCC (Figure 3(a)), vimentin (Figure 3(b)), pan-CK, EMA (Figure 4(a)), and CD10, but no reaction was observed with the other immune indicators.
Diffuse positive membranous immunoreaction with antibodies against EMA (a) and focal positive nuclear Ki-67 immunoreaction (b) are observed in the clear cells (ABC-DAB; (a) x200; (b) x400).
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fig4
The tumor cells reacted positively with RCC (Figure 3(a)), vimentin (Figure 3(b)), pan-CK, EMA (Figure 4(a)), and CD10, but no reaction was observed with the other immune indicators. A 5% Ki67 index was determined for the neoplastic cells (Figure 4(b)).