PMC6343171_01
H&E staining and IHC characterization of the renal oncocytoma from the patient carrying the germline VHL deletion. (a) H&E staining of tumor tissue. (b, c) IHC for Complex V, subunit D in the renal oncocytoma (b) and in a normal kidney used as control (c), both with a QS of 8 (P = 4, I = 2). Magnification for all IHC images: 200x.
OMCL2019-8069583.001.jpg
PMC6343171_01_OMCL2019-8069583.001.jpg
fig1
Almost all tumor cells displayed intense and diffuse eosinophilic cytoplasmic granularity (Figure 1(a)) consequent to mitochondrial overload as observed with the positive anti-OxPhos antibody (Figures 1(b)-1(c)).