PMC2741561_01
The flourescein angiography photograph (B) shows a fluorescence block for multiple dot subretinal hemorrhage, cotton-wool spots and vein meandering with the color fundus photograph (A), but it does not show the avascular area. Three months later, the fundus photograph (C) shows an almost normal retina appearance although dot subretinal hemorrhage and cotton-wool spots remain. The flourescein angiography photograph (D) shows no abnormality. The OCT shows remarkable macular edema, with the macular thickness indicated at 638 mum (E). (F) Macular thickness the following day shows 220 mum. The retinal thickness was reduced to 140 mum three months later.. Abbreviation: OCT, optical coherence tomography.
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Ocular fundus findings included massive dilatation of the retinal veins, widespread dot-blot hemorrhages, and multiple cotton-wool spots (Figure 1A). In addition, macular edema was determined by optical coherence tomography (Zeiss Straus OCT; OCT3, Carl Zeiss Meditec, Jena, Germany) (Figure 1E). The macular edema and the ONH circulation, particularly the central retinal artery (CRA) blood flow, improved a few days after the aspirin administration was initiated (Figures 1E and F, Figures 2A and C), and her left visual acuity also improved to 0.8. Three months later, her visual acuity was restored to 1.2, and macular edema had disappeared completely (Figure 1G).
Optic nerve head blood flow levels by LSFG. We show examinations with LSFG from the first and second days, as well as three months later. B, D, and F are monochrome-converted images of A, C and E, respectively, which makes observing optic nerve heads and vessels easier. The square shows the blood flow (A, C, E) measurement part of CRA, both the optic nerve head of the nasal side as well as the temporal side. The blood flow rate in the CRA improved by 84.3%, on the temporal side it improved by 32% and that of the nasal side showed a 3.9% improvement. Three months later, the CRA blood flow rate was shown to have improved by 253%, although that of the temporal side and nasal side of ONH decreased by 10% and 15%, respectively.. Abbreviations: CRA, central retinal artery; LSFG, laser speckle flowgraphy; ONH, optic nerve head.
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LSFG indicated ONH blood flow levels were markedly decreased (Figure 2A). The macular edema and the ONH circulation, particularly the central retinal artery (CRA) blood flow, improved a few days after the aspirin administration was initiated (Figures 1E and F, Figures 2A and C), and her left visual acuity also improved to 0.8. In terms of ocular hemodynamics, LSFG showed a further increase of CRA blood flow and no abnormal findings by FA (Figure 2D and E).