PMC7399447_01
Brain MRI of the patient: axial plane of T1-weighted brain MRI (A) with and (B) without contrast. (C) Sagittal plane of T1-weighted brain MRI. MRI of the brain shows a low-signal, heterogeneous mass in T2 and T1 in the right frontal lobe area, extending to the right parietal area and with significant midline shift to the left. After contrast injection, a punctuate enhancement was reported.
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Given the imaging findings, the differential diagnoses of low-grade glioma and brain lymphoma were rendered (Figure 1).
(A) Hematoxylin and eosin staining, 400x, showing cartilaginous lobules without atypia, mitosis, or necrosis and (B) positive IHC staining of S100 marker.
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There was no evidence of brain parenchyma or dura (Figure 2A). To determine the exact nature of the mass, immunohistochemical staining for EMA, CK, GFAP, and S100 markers was performed, which was positive for S100 and negative for the other three markers (Figure 2B).