PMC3965941_01
Clockwise, from left: nodular lesions involving the face in a disseminated pattern, mimicking lepromatous leprosy; the boggy pus draining lesions at the back with ulceronodular features (black arrow); eye involvement in the form of nodules on the conjunctiva (yellow arrow) and conjunctival suffusion (green arrow); mucous surface involvement in the form of broken down nodular lesion on the soft palate (red arrow).
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fig1
These lesions were shiny and without skin changes and a few of them showed pus drainage from the central sunken areas (Figure 1).
Histopathological examination of the liver (a) and skin lesion (b) showing features of LD bodies in the former and amastigote forms in the latter. H&E stain (400x) and eosin stain (400x), respectively.
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fig2
The dermis showed loss of adnexal structures and a rich collection of histiocytes filled with amastigote forms of leishmaniasis (Figure 2(a)). The hyperplastic Kupffer cells and granulomatous collection of macrophages showed presence of intracellular LD bodies (Figure 2(b)) which was also subsequently shown in the bone marrow biopsy (Figure 3).
Histopathological examination of the bone marrow showing LD bodies within the histiocytic macrophages (black arrow); eosin stain (1000x).
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fig3
The hyperplastic Kupffer cells and granulomatous collection of macrophages showed presence of intracellular LD bodies (Figure 2(b)) which was also subsequently shown in the bone marrow biopsy (Figure 3).