PMC5240303_01
a- b patient 1. c-d patient 2. a and c H&E 20x. Tubulointerstitial inflammation with eosinophils and acute tubular epithelial cell injury. b and c DIF 20x. IgG reactive interstitial plasma cells with tubulointerstitial inflammation
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Fig1
Renal biopsy (Fig. 1) demonstrated diffuse active tubulointerstitial nephritis with severe acute tubular cell injury. Immunofluorescence revealed no glomerular, tubular or vascular wall immune staining (Fig. 1).
Immunohistochemistry of renal biopsies from patients 2 (top panel: a) and 1 (bottom panel: b) reveals an inflammatory infiltrate composed of CD4 and CD8 T-cells and macrophages.
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Fig2
Immunohistochemistry revealed an inflammatory infiltrate composed of CD4 and CD8 T-cells and macrophages (Fig. 2).    In May 2015, the patient presented with a new subcutaneous nodule on the anterior left leg (Fig. 2), which was confirmed as metastatic melanoma. Immunohistochemistry revealed an inflammatory infiltrate composed of CD4 and CD8 T-cells and macrophages (Fig. 2).