PMC4109629_01
(A) Erythema and hundreds of tiny pustules on the thigh. (B) Skin biopsy revealed formation of subcorneal pustules containing neutrophil aggregates and Kogoj spongiform pustules in the base of the epidermis, and superficial perivascular neutrophil infiltration in the dermis. (C) Mass of scales on the thigh after treatment.
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Case 1 was a 50-year-old woman who presented with a large area of erythema and hundreds of tiny nonfollicular pustules, and a 2-week history of itching and pain from head to foot (Figure 1A). Histopathological examination of a biopsy from a pustule was consistent with a diagnosis of acute generalized exanthematous pustulosis (AGEP, Figure 1B). The patient's condition improved further with gradually tapering doses of methylprednisolone (Figure 1C) during a hospital stay of 20 days.
PMC4109629_02
(A) Erythema and lots of tiny pustules on the abdomen. (B) Many pustules on the basis of erythema on the lower abdomen.
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Case 2 (Figure 2A and B) was an 89-year-old man who presented with a 1-week history of generalized erythema, tiny pustules, and pruritus.
PMC4109629_03
(A) Lots of tiny pustules on the trunk. (B) Many tiny pustules and some scales on the upper limbs.
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Three days later, many tiny pustules appeared on the upper limbs (Figure 3B), which disappeared on the following day.
PMC4109629_04
(A) Lots of tiny pustules on the trunk. (B) Many tiny pustules and some scales on the upper limbs.
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Three days later, many tiny pustules appeared on the upper limbs (Figure 3B), which disappeared on the following day.