PMC2828429_01
PMC2828429_02
Endobronchi tumor proliferation (HE x40).
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F1
Histological findings revealed an endobronchial and submucosal tumor composed of a proliferation of small cells, with a predominantly whorled pattern (Fig 1, 2).
Small cells proliferation of plasmocytoid-type, in a whorled pattern. The nuclei showed dispersed chromatin with no mitotic activity (HE x400).
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F2
Histological findings revealed an endobronchial and submucosal tumor composed of a proliferation of small cells, with a predominantly whorled pattern (Fig 1, 2). Most of the cells appeared as plasmocytoid-type (Fig 2). A clear cell changes were focally seen throughout the tumor (Fig 2).
Immunohistochemestry: Diffuse positivity for Actine smooth muscle.
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F3
The tumor cells were not only positive for smooth muscle actin (Fig 3) and vimentine, but also for S100 protein (Fig 4).
Tumor cells positive to S100 protein.
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F4
The tumor cells were not only positive for smooth muscle actin (Fig 3) and vimentine, but also for S100 protein (Fig 4).
Tumor cells negatives to cytokeratine.
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F5
Tumor cells were negative for cytokeratine (Fig 5), neuroendocrine markers including chromogranine and synaptophysin as well as for epithelial membrane antigen, desmin, HMB45 and CD34.