PMC3504212_01
(a) Collapsed glomerular capillary loops with obliteration of vascular spaces are noted. Podocyte hyperplasia and synechiae formation along with tubular atrophy are evident (Hematoxylin-eosin 100x),(b) high-power view showing prominent collapse of glomerular tuft with obliteration of vascular spaces along with pseudocrescent formation (Jones-Silver stain 400x), and (c) electron microscopy showing collapse of the glomerular tuft with basement membrane wrinkling, podocyte enlargement, and effacement of foot processes. No tubuloreticular inclusions in endothelial cells are seen (2,950x).
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PMC3504212_01_CRIM.TRANSPLANTATION2011-263970.001.jpg
fig1
Biopsy findings are shown in Figure 1.Figure 1(a) shows collapsed capillary loops in two glomeruli with complete obliteration of the vascular spaces. The glomerular changes were diagnostic of CG.  Figure 1(b) is higher-power view of a glomerulus showing prominent collapse of the glomerular tuft with obliteration of vascular space. Also evident is hypertrophy and hyperplasia of visceral epithelial cells (pseudocrescent), a hallmark of CG.  Figure 1(c) shows collapse of the tuft with basement membrane wrinkling, enlarged podocyte, and effacement of foot processes, changes consistent with CG.