PMC8531482_01
Patient's family tree according to the boy's mother.
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F1
BMI, which was insignificant, followed by a reduction of body mass and reaching a BMI at the third percentile at the age of 15, which requires attention and subsequent follow-up (Supplementary Figure 1). Because of this fact, we planned an increase in energy intake and scheduled a consultation with a pediatric dietologist.
PMC8531482_02
(A) Initial fibrocalcinous changes on the aortic root and on the mitral valve annulus. (B) Initial intima media thickness of the last 10 mm of the right common carotid artery.
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F2
Echocardiography revealed posterior annular calcification of the mitral valve and thickened and sclerotic aortic valve without any pathological gradient, normal ejection fraction (67%), and normal global longitudinal strain (-25%) (Figure 2). Intima-media thickness of the carotid arteries was elevated for the patient's age and corresponded to the values of a 30-year-old male (Figure 2).
Dynamics of LDL-C, non-HDL-C, Apolipoprotein B/A1 during the 5-year follow-up.
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F3
Since January 2020, the target levels have been successfully preserved below 3.5 mmol/l. (Figure 3). The dynamics of the different lipid profile values during the 5-year course are displayed in Figure 3.
PMC8531482_03
Patient's family tree according to the boy's mother.
fcvm-08-743341-g0001.jpg
PMC8531482_03_fcvm-08-743341-g0001.jpg
F1
BMI, which was insignificant, followed by a reduction of body mass and reaching a BMI at the third percentile at the age of 15, which requires attention and subsequent follow-up (Supplementary Figure 1). Because of this fact, we planned an increase in energy intake and scheduled a consultation with a pediatric dietologist.
Dynamics of LDL-C, non-HDL-C, Apolipoprotein B/A1 during the 5-year follow-up.
fcvm-08-743341-g0003.jpg
PMC8531482_03_fcvm-08-743341-g0003.jpg
F3
Since January 2020, the target levels have been successfully preserved below 3.5 mmol/l. (Figure 3). The dynamics of the different lipid profile values during the 5-year course are displayed in Figure 3.
Involution of the xanthomas during the 5-year follow-up.
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F4
Skin lesions' appearance during the 5-year period is shown on Figure 4.