PMC6598318_01
Presurgery in vitro spiking of rFVIIa.. rFVIIa, recombinant activated Factor VII.
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fig1-2040620719860025
Table 1, Figure 1), aPCC (0.05 IU/ml, 0.1 IU/ml, 0.2 IU/ml, 0.3 IU/ml, 0.5 IU/ml, 0.75 IU/ml; Table 2, Figure 2) and porcine FVIII (50 IU/ml, 100 IU/ml 200 IU/ml; Table 3, Figure 3) in vitro into the patient's plasma and whole blood and analyzed the results. The patient had an excellent TGA response to rFVIIa demonstrating an increasing endogenous thrombin potential (ETP) and peak thrombin as expected.
Presurgery in vitro spiking of aPCC.. aPCC, activated prothrombin complex concentrate.
10.1177_2040620719860025-fig2.jpg
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fig2-2040620719860025
Table 1, Figure 1), aPCC (0.05 IU/ml, 0.1 IU/ml, 0.2 IU/ml, 0.3 IU/ml, 0.5 IU/ml, 0.75 IU/ml; Table 2, Figure 2) and porcine FVIII (50 IU/ml, 100 IU/ml 200 IU/ml; Table 3, Figure 3) in vitro into the patient's plasma and whole blood and analyzed the results. The patient had an excellent TGA response to rFVIIa demonstrating an increasing endogenous thrombin potential (ETP) and peak thrombin as expected.
Presurgery in vitro spiking of porcine FVIII.
10.1177_2040620719860025-fig3.jpg
PMC6598318_01_10.1177_2040620719860025-fig3.jpg
fig3-2040620719860025
Table 1, Figure 1), aPCC (0.05 IU/ml, 0.1 IU/ml, 0.2 IU/ml, 0.3 IU/ml, 0.5 IU/ml, 0.75 IU/ml; Table 2, Figure 2) and porcine FVIII (50 IU/ml, 100 IU/ml 200 IU/ml; Table 3, Figure 3) in vitro into the patient's plasma and whole blood and analyzed the results. The patient had an excellent TGA response to rFVIIa demonstrating an increasing endogenous thrombin potential (ETP) and peak thrombin as expected.
Perioperative management.
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The patient has continued physical therapy as an outpatient and has had an overall outstanding result (currently 11 months after surgery) with restoration of mobility in his right knee and a reduction in his pain which is currently related to his ongoing physical therapy (Figure 4).