PMC8351025_01
(a) 59 year-old woman with metastatic endometrial stromal sarcoma treated with chemotherapy. CT chest with contrast (upper row) demonstrates scattered peripheral cystic nodules compatible with treated metastatic disease. CT chest without contrast 2 months later (bottom row) demonstrates interval development of a spontaneous large left pneumothorax. Note the subpleural location of several of the left lung nodules, which may result in a pneumothorax secondary to pleural rupture, (b) 56 year-old woman with metastatic endometrial stromal sarcoma. CT chest with contrast (upper row) demonstrates multiple bilateral pulmonary parenchymal nodules compatible with metastatic disease. CT chest with contrast following 2 months of chemotherapy (bottom row) demonstrates interval development of spontaneous large right and moderate left pneumothoraces. Many of the parenchymal nodules have undergone cystic transformation following chemotherapy.
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PMC8351025_02_10.1177_2036361320972865-fig1.jpg
fig1-2036361320972865
A CT angiography during admission redemonstrated innumerable solid pulmonary nodules, now with central cavitation (Figure 1(b)). This can result in simultaneous cystic and solitary nodular lesions as was seen in Figure 1. As seen in Figure 1(b), as these parenchymal nodules evolve, they can undergo cystic transformation and depending on their location within the lung, can result in pneumothoraces.
PMC8351025_02
(a) 59 year-old woman with metastatic endometrial stromal sarcoma treated with chemotherapy. CT chest with contrast (upper row) demonstrates scattered peripheral cystic nodules compatible with treated metastatic disease. CT chest without contrast 2 months later (bottom row) demonstrates interval development of a spontaneous large left pneumothorax. Note the subpleural location of several of the left lung nodules, which may result in a pneumothorax secondary to pleural rupture, (b) 56 year-old woman with metastatic endometrial stromal sarcoma. CT chest with contrast (upper row) demonstrates multiple bilateral pulmonary parenchymal nodules compatible with metastatic disease. CT chest with contrast following 2 months of chemotherapy (bottom row) demonstrates interval development of spontaneous large right and moderate left pneumothoraces. Many of the parenchymal nodules have undergone cystic transformation following chemotherapy.
10.1177_2036361320972865-fig1.jpg
PMC8351025_02_10.1177_2036361320972865-fig1.jpg
fig1-2036361320972865
A CT angiography during admission redemonstrated innumerable solid pulmonary nodules, now with central cavitation (Figure 1(b)). This can result in simultaneous cystic and solitary nodular lesions as was seen in Figure 1. As seen in Figure 1(b), as these parenchymal nodules evolve, they can undergo cystic transformation and depending on their location within the lung, can result in pneumothoraces.
(a) Atypical round cells with more angulated and irregular nuclear outlines, HE x 200x, (b) cells with pleomorphism and prominent mitotic figures, HE x 400x, (c) tumor cells showing CD10 positivity, CD10 x 200x, and (d) tumor cells showing ER positivity, ER x 200x.
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PMC8351025_02_10.1177_2036361320972865-fig2.jpg
fig2-2036361320972865
The mitotic count was high (18/10 hpf) and with areas of necrosis present (Figure 2(a) and (b)). Immunostain for CD10 was positive in both cases (Figure 2(c)) and ER immunostain was positive in one case (Figure 2(d)).