PMC9709395_01
PMC9709395_02
Changes in biochemical indices and medicine dosage of the patients. Elemental calcium (mg); active vitamin D, calcitriol (mug); plain vitamin D, calciferol/cholecalciferol (IU); serum PTH, serum parathyroid hormone level (ng/ml); SCa, serum calcium level (mmol/L); pre, prepregnancy; w, gestation week; post, postpregnancy; m, month after delivery. (A) Drug dosage, serum calcium, and PTH level of patient 1. (B) Drug dosage, serum calcium, and PTH level of patient 2. (C) Drug dosage, serum calcium, and PTH level of patient 3. (D) Drug dosage, serum calcium, and PTH level of patient 4. (Ea) Drug dosage, serum calcium, and PTH level of patient 5's first pregnancy. (Eb) Drug dosage, serum calcium, and PTH level of patient 5's third pregnancy.
fendo-13-1050305-g001.jpg
PMC9709395_08_fendo-13-1050305-g001.jpg
f1
Calcium metabolism also worsened during this pregnancy period ( Tables 2 ,  3 ;  Figure 1Eb ). Figure 1 , during pregnancy, calcium homeostasis was described as stable in Pt 1 due to stable serum calcium level and drug dosage ( Figure 1A ), improved in Pt 3 due to increased serum calcium and reduced drug dosage ( Figure 1C ), and worsened in Pt 5 because of the obviously decreased serum calcium level and increased drug dosage during the two pregnancies ( Figure 1E ). For patients 2 and 4, the changes in PHP condition were difficult to evaluate due to the lack of prepregnancy data and the change in vitamin D agent type ( Figures 1B, D ). And for the third pregnancy of patient 5, whose condition has worsened, the PTH level was slightly increased in the last two trimesters compared to that of the first trimester ( Table 2 ;  Figure 1 ). Increased serum calcium and PTH levels were found during these two lactation periods compared to those during pregnancy ( Table 2 ;  Figure 1E ). The serum calcium level increased from 2.19 (week 28) to 2.49 mmol/L (3 months postpartum) with stable medicine and declined PTH level (from 113 to 49.9 pg/ml) in patient 1 ( Figure 1A ). Calcitriol was reduced from 1 mug/day (week 32) to 0.25 mug/day (3 months postpartum) with stable serum calcium and increased PTH level (from 25.6 to 75.1 pg/ml) in Pt 4 ( Figure 1D ).
PMC9709395_03
PMC9709395_04
Changes in biochemical indices and medicine dosage of the patients. Elemental calcium (mg); active vitamin D, calcitriol (mug); plain vitamin D, calciferol/cholecalciferol (IU); serum PTH, serum parathyroid hormone level (ng/ml); SCa, serum calcium level (mmol/L); pre, prepregnancy; w, gestation week; post, postpregnancy; m, month after delivery. (A) Drug dosage, serum calcium, and PTH level of patient 1. (B) Drug dosage, serum calcium, and PTH level of patient 2. (C) Drug dosage, serum calcium, and PTH level of patient 3. (D) Drug dosage, serum calcium, and PTH level of patient 4. (Ea) Drug dosage, serum calcium, and PTH level of patient 5's first pregnancy. (Eb) Drug dosage, serum calcium, and PTH level of patient 5's third pregnancy.
fendo-13-1050305-g001.jpg
PMC9709395_08_fendo-13-1050305-g001.jpg
f1
Calcium metabolism also worsened during this pregnancy period ( Tables 2 ,  3 ;  Figure 1Eb ). Figure 1 , during pregnancy, calcium homeostasis was described as stable in Pt 1 due to stable serum calcium level and drug dosage ( Figure 1A ), improved in Pt 3 due to increased serum calcium and reduced drug dosage ( Figure 1C ), and worsened in Pt 5 because of the obviously decreased serum calcium level and increased drug dosage during the two pregnancies ( Figure 1E ). For patients 2 and 4, the changes in PHP condition were difficult to evaluate due to the lack of prepregnancy data and the change in vitamin D agent type ( Figures 1B, D ). And for the third pregnancy of patient 5, whose condition has worsened, the PTH level was slightly increased in the last two trimesters compared to that of the first trimester ( Table 2 ;  Figure 1 ). Increased serum calcium and PTH levels were found during these two lactation periods compared to those during pregnancy ( Table 2 ;  Figure 1E ). The serum calcium level increased from 2.19 (week 28) to 2.49 mmol/L (3 months postpartum) with stable medicine and declined PTH level (from 113 to 49.9 pg/ml) in patient 1 ( Figure 1A ). Calcitriol was reduced from 1 mug/day (week 32) to 0.25 mug/day (3 months postpartum) with stable serum calcium and increased PTH level (from 25.6 to 75.1 pg/ml) in Pt 4 ( Figure 1D ).
PMC9709395_05
Changes in biochemical indices and medicine dosage of the patients. Elemental calcium (mg); active vitamin D, calcitriol (mug); plain vitamin D, calciferol/cholecalciferol (IU); serum PTH, serum parathyroid hormone level (ng/ml); SCa, serum calcium level (mmol/L); pre, prepregnancy; w, gestation week; post, postpregnancy; m, month after delivery. (A) Drug dosage, serum calcium, and PTH level of patient 1. (B) Drug dosage, serum calcium, and PTH level of patient 2. (C) Drug dosage, serum calcium, and PTH level of patient 3. (D) Drug dosage, serum calcium, and PTH level of patient 4. (Ea) Drug dosage, serum calcium, and PTH level of patient 5's first pregnancy. (Eb) Drug dosage, serum calcium, and PTH level of patient 5's third pregnancy.
fendo-13-1050305-g001.jpg
PMC9709395_08_fendo-13-1050305-g001.jpg
f1
Calcium metabolism also worsened during this pregnancy period ( Tables 2 ,  3 ;  Figure 1Eb ). Figure 1 , during pregnancy, calcium homeostasis was described as stable in Pt 1 due to stable serum calcium level and drug dosage ( Figure 1A ), improved in Pt 3 due to increased serum calcium and reduced drug dosage ( Figure 1C ), and worsened in Pt 5 because of the obviously decreased serum calcium level and increased drug dosage during the two pregnancies ( Figure 1E ). For patients 2 and 4, the changes in PHP condition were difficult to evaluate due to the lack of prepregnancy data and the change in vitamin D agent type ( Figures 1B, D ). And for the third pregnancy of patient 5, whose condition has worsened, the PTH level was slightly increased in the last two trimesters compared to that of the first trimester ( Table 2 ;  Figure 1 ). Increased serum calcium and PTH levels were found during these two lactation periods compared to those during pregnancy ( Table 2 ;  Figure 1E ). The serum calcium level increased from 2.19 (week 28) to 2.49 mmol/L (3 months postpartum) with stable medicine and declined PTH level (from 113 to 49.9 pg/ml) in patient 1 ( Figure 1A ). Calcitriol was reduced from 1 mug/day (week 32) to 0.25 mug/day (3 months postpartum) with stable serum calcium and increased PTH level (from 25.6 to 75.1 pg/ml) in Pt 4 ( Figure 1D ).
PMC9709395_06
Changes in biochemical indices and medicine dosage of the patients. Elemental calcium (mg); active vitamin D, calcitriol (mug); plain vitamin D, calciferol/cholecalciferol (IU); serum PTH, serum parathyroid hormone level (ng/ml); SCa, serum calcium level (mmol/L); pre, prepregnancy; w, gestation week; post, postpregnancy; m, month after delivery. (A) Drug dosage, serum calcium, and PTH level of patient 1. (B) Drug dosage, serum calcium, and PTH level of patient 2. (C) Drug dosage, serum calcium, and PTH level of patient 3. (D) Drug dosage, serum calcium, and PTH level of patient 4. (Ea) Drug dosage, serum calcium, and PTH level of patient 5's first pregnancy. (Eb) Drug dosage, serum calcium, and PTH level of patient 5's third pregnancy.
fendo-13-1050305-g001.jpg
PMC9709395_08_fendo-13-1050305-g001.jpg
f1
Calcium metabolism also worsened during this pregnancy period ( Tables 2 ,  3 ;  Figure 1Eb ). Figure 1 , during pregnancy, calcium homeostasis was described as stable in Pt 1 due to stable serum calcium level and drug dosage ( Figure 1A ), improved in Pt 3 due to increased serum calcium and reduced drug dosage ( Figure 1C ), and worsened in Pt 5 because of the obviously decreased serum calcium level and increased drug dosage during the two pregnancies ( Figure 1E ). For patients 2 and 4, the changes in PHP condition were difficult to evaluate due to the lack of prepregnancy data and the change in vitamin D agent type ( Figures 1B, D ). And for the third pregnancy of patient 5, whose condition has worsened, the PTH level was slightly increased in the last two trimesters compared to that of the first trimester ( Table 2 ;  Figure 1 ). Increased serum calcium and PTH levels were found during these two lactation periods compared to those during pregnancy ( Table 2 ;  Figure 1E ). The serum calcium level increased from 2.19 (week 28) to 2.49 mmol/L (3 months postpartum) with stable medicine and declined PTH level (from 113 to 49.9 pg/ml) in patient 1 ( Figure 1A ). Calcitriol was reduced from 1 mug/day (week 32) to 0.25 mug/day (3 months postpartum) with stable serum calcium and increased PTH level (from 25.6 to 75.1 pg/ml) in Pt 4 ( Figure 1D ).
PMC9709395_07
Changes in biochemical indices and medicine dosage of the patients. Elemental calcium (mg); active vitamin D, calcitriol (mug); plain vitamin D, calciferol/cholecalciferol (IU); serum PTH, serum parathyroid hormone level (ng/ml); SCa, serum calcium level (mmol/L); pre, prepregnancy; w, gestation week; post, postpregnancy; m, month after delivery. (A) Drug dosage, serum calcium, and PTH level of patient 1. (B) Drug dosage, serum calcium, and PTH level of patient 2. (C) Drug dosage, serum calcium, and PTH level of patient 3. (D) Drug dosage, serum calcium, and PTH level of patient 4. (Ea) Drug dosage, serum calcium, and PTH level of patient 5's first pregnancy. (Eb) Drug dosage, serum calcium, and PTH level of patient 5's third pregnancy.
fendo-13-1050305-g001.jpg
PMC9709395_08_fendo-13-1050305-g001.jpg
f1
Calcium metabolism also worsened during this pregnancy period ( Tables 2 ,  3 ;  Figure 1Eb ). Figure 1 , during pregnancy, calcium homeostasis was described as stable in Pt 1 due to stable serum calcium level and drug dosage ( Figure 1A ), improved in Pt 3 due to increased serum calcium and reduced drug dosage ( Figure 1C ), and worsened in Pt 5 because of the obviously decreased serum calcium level and increased drug dosage during the two pregnancies ( Figure 1E ). For patients 2 and 4, the changes in PHP condition were difficult to evaluate due to the lack of prepregnancy data and the change in vitamin D agent type ( Figures 1B, D ). And for the third pregnancy of patient 5, whose condition has worsened, the PTH level was slightly increased in the last two trimesters compared to that of the first trimester ( Table 2 ;  Figure 1 ). Increased serum calcium and PTH levels were found during these two lactation periods compared to those during pregnancy ( Table 2 ;  Figure 1E ). The serum calcium level increased from 2.19 (week 28) to 2.49 mmol/L (3 months postpartum) with stable medicine and declined PTH level (from 113 to 49.9 pg/ml) in patient 1 ( Figure 1A ). Calcitriol was reduced from 1 mug/day (week 32) to 0.25 mug/day (3 months postpartum) with stable serum calcium and increased PTH level (from 25.6 to 75.1 pg/ml) in Pt 4 ( Figure 1D ).
PMC9709395_08
Changes in biochemical indices and medicine dosage of the patients. Elemental calcium (mg); active vitamin D, calcitriol (mug); plain vitamin D, calciferol/cholecalciferol (IU); serum PTH, serum parathyroid hormone level (ng/ml); SCa, serum calcium level (mmol/L); pre, prepregnancy; w, gestation week; post, postpregnancy; m, month after delivery. (A) Drug dosage, serum calcium, and PTH level of patient 1. (B) Drug dosage, serum calcium, and PTH level of patient 2. (C) Drug dosage, serum calcium, and PTH level of patient 3. (D) Drug dosage, serum calcium, and PTH level of patient 4. (Ea) Drug dosage, serum calcium, and PTH level of patient 5's first pregnancy. (Eb) Drug dosage, serum calcium, and PTH level of patient 5's third pregnancy.
fendo-13-1050305-g001.jpg
PMC9709395_08_fendo-13-1050305-g001.jpg
f1
Calcium metabolism also worsened during this pregnancy period ( Tables 2 ,  3 ;  Figure 1Eb ). Figure 1 , during pregnancy, calcium homeostasis was described as stable in Pt 1 due to stable serum calcium level and drug dosage ( Figure 1A ), improved in Pt 3 due to increased serum calcium and reduced drug dosage ( Figure 1C ), and worsened in Pt 5 because of the obviously decreased serum calcium level and increased drug dosage during the two pregnancies ( Figure 1E ). For patients 2 and 4, the changes in PHP condition were difficult to evaluate due to the lack of prepregnancy data and the change in vitamin D agent type ( Figures 1B, D ). And for the third pregnancy of patient 5, whose condition has worsened, the PTH level was slightly increased in the last two trimesters compared to that of the first trimester ( Table 2 ;  Figure 1 ). Increased serum calcium and PTH levels were found during these two lactation periods compared to those during pregnancy ( Table 2 ;  Figure 1E ). The serum calcium level increased from 2.19 (week 28) to 2.49 mmol/L (3 months postpartum) with stable medicine and declined PTH level (from 113 to 49.9 pg/ml) in patient 1 ( Figure 1A ). Calcitriol was reduced from 1 mug/day (week 32) to 0.25 mug/day (3 months postpartum) with stable serum calcium and increased PTH level (from 25.6 to 75.1 pg/ml) in Pt 4 ( Figure 1D ).