PMC4069135_01
CT scan, October 2012 (before vemurafenib therapy).. Abbreviation: CT, computed tomography.
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After the fifth chemotherapy cycle, further evaluations showed increase in the diameters of the right inguinal, iliac, and obturator lymph nodes (CT scan, Figure 1) and abnormal fluorodeoxyglucose uptake in the same sites.
Comparison between PET at baseline (upper row) and PET after 1 month of vemurafenib therapy (lower row).. Abbreviation: PET, positron emission tomography.
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After the first month of vemurafenib treatment, evaluation with PET and CT scan revealed volume reduction and metabolic silencing of pelvic and inguinal adenopathies (Figure 2).
CT scan, July 2013, after 10 months of vemurafenib therapy.. Note: Imaging shows near-complete resolution of previously enlarged pelvic and inguinal nodes.. Abbreviation: CT, computed tomography.
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After 10 months of vemurafenib treatment, radiographic control showed complete morphological and metabolic remission of disease (Figure 3).