PMC5498199_01
The Progression of the Echocardiographic Data and the Examination Findings..
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Cardiac MRI showed diffuse hypertrophy in the left ventricular wall (Fig. 1A, B). Late gadolinium enhancement was seen in the basal- to mid-inferolateral wall of the left ventricular subepicardial myocardium (Fig. 1C).
Cardiac magnetic resonance imaging (MRI). A and B: Perfusion images. C: Delayed gadolinium enhancement.
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Light microscopy of hematoxylin and eosin-stained sections revealed a lack of myofibrillar disarray, clear cellular reticula, and ceramide deposition within the cellular reticula (Fig. 2A). Although other staining methods were applied, there were no significant findings (Fig. 2B, C, D).
Light micrographs of a left ventricular endomyocardial biopsy specimen. A: Hematoxylin and Eosin staining (x100). B: Elastica van Gieson staining (x100). C: Periodic acid-Schiff staining (x100). D: Congo red staining (x100).
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In addition, electron microscopy revealed the enargement of the mitochondrial cells (1.0-2.5 mum in diameter), which exhibited abnormal hyperplasia, central core lysis in the cristae, and abnormal concentric circular lamination (Fig. 3).