PMC3891161_01
Uterine cervix punch biopsy shows invasive squamous cell carcinoma, keratinizing type. Hematoxylin and eosin stain (x200)
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F1
Microscopically, the biopsy specimen revealed a keratinizing type invasive squamous cell carcinoma (Figure 1).
Abdomen and pelvic MRI scan shows 5.5x3.5 cm high signal intensity mass in the uterine cervix.
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F2
There was a 5.5x3.5 cm high signal intensity mass in the uterine cervix with invasion of the left parametrium and a 1 cm lymph node in the left external iliac area on MRI scan (Figure 2).
Bone marrow examination shows granulocytic reactive marrow. No evidence of bone marrow involvement of malignant tumor was detected. Wright, Giemsa stain (x400).
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F3
There was no evidence of bone marrow involvement of malignant tumor (Figure 3).
Immunohistochemical staining of G-CSF(A), IL-6(B) (x200).
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F4
Staining for G-CSF and IL-6 was mainly observed in the cytoplasm of cancer cells (Figure 4A, 4B).
Follow-up abdomen and pelvic MRI scan shows no cervical mass.
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F5
After these treatments, the cervical mass was no longer seen in the follow up MRI scan (Figure 5).
Follow-up chest X-ray shows markedly increased metastatic nodules of right lower lobe and left upper lobe and newly developed metastatic nodule in right upper lobe.
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F6
After four cycles of treatment, a marked increase in metastatic lung nodules was found on the follow-up chest X-ray (Figure 6), with severe granuocytosis (52,700/microL).