PMC4469988_01
(A) Computed tomography chest images upon admission from Case 1 (left) and Case 2 (right) demonstrated ground-glass opacities (arrows) in lung parenchyma. (B) Decrease in parainfluenza virus load by quantitative polymerase chain reaction in tracheal samples obtained daily during the 5-day treatment course on both patients. (C) Plasma concentration of DAS181 during the course of treatment remained low.
nihms699032f1.jpg
PMC4469988_02_nihms699032f1.jpg
F1
Center with fever, hemoptysis, and respiratory distress, and was found to be hemodynamically unstable. Chest CT demonstrated ground-glass opacities in the right upper lobe (Fig. 1A, right), and he required mechanical ventilation. During the treatment course, tracheal aspirates were obtained daily and PIV-3 load was quantified by PCR and decreased substantially while on treatment with DAS181 (Fig. 1B). Drug levels in plasma were closely monitored and remained within a low level, 1.13-2.43 ng/mL (Fig. 1C).
PMC4469988_02
(A) Computed tomography chest images upon admission from Case 1 (left) and Case 2 (right) demonstrated ground-glass opacities (arrows) in lung parenchyma. (B) Decrease in parainfluenza virus load by quantitative polymerase chain reaction in tracheal samples obtained daily during the 5-day treatment course on both patients. (C) Plasma concentration of DAS181 during the course of treatment remained low.
nihms699032f1.jpg
PMC4469988_02_nihms699032f1.jpg
F1
Center with fever, hemoptysis, and respiratory distress, and was found to be hemodynamically unstable. Chest CT demonstrated ground-glass opacities in the right upper lobe (Fig. 1A, right), and he required mechanical ventilation. During the treatment course, tracheal aspirates were obtained daily and PIV-3 load was quantified by PCR and decreased substantially while on treatment with DAS181 (Fig. 1B). Drug levels in plasma were closely monitored and remained within a low level, 1.13-2.43 ng/mL (Fig. 1C).