PMC7585506_01
Photo image: two small ulcerations, with delicate rims and indurated bases, emerged within the margins of a large scar on the right nasal wing. Histologic image: Islands and nests of basaloid cells, with palisading of the cells at the periphery and a haphazard arrangement of those cells in the centers of the islands. The tumor cells have a hyperchromatic nucleus with relatively little, poorly defined cytoplasm. An inflammatory cell infiltrate is present. The epidermis is ulcerated (HE 10X).
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The scar was, in fact, an old cutaneous flap, round shaped and well delineated, achieved decades ago subsequent to a caustic burn (Figure 1).  Histologic examination described: islands and nests of basaloid cells, with palisading of the cells at the periphery and a haphazard arrangement of those cells in the centers of the islands; the tumor cells with hyperchromatic nucleus and relatively little, poorly defined cytoplasm and inflammatory cell infiltrate (Figure 1).
PMC7585506_02
Photo image: Eczematous-like lesion, located on the right third digital pulp, on an area of severe scarring and contracture. Histologic image: Nests of squamous epithelial cells in the dermis. The cells have abundant eosinophilic cytoplasm and a large, vesicular, nucleus. There is variable central keratinization and horn pearl formation. Individual cell keratinization is also present (HE 40X).
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A 64-year-old female retired nurse, with allergic background, has been treated for months for an eczematous-like lesion, located on the right third digital pulp, on an area of severe scarring and contracture, induced by a critical burn, occurred three decades previously (Figure 2). Histologic examination described: nests of squamous epithelial cells in the dermis, characterized by abundant eosinophilic cytoplasm and a large, vesicular, nucleus (Figure 2).
PMC7585506_03
Photo image: Small papule, surrounding by ulceration within the area of stasis dermatitis. Histologic image: Nests of squamous epithelial cells in the dermis. The cells have abundant eosinophilic cytoplasm and a large, vesicular, nucleus. There is variable central keratinization and horn pearl formation. Individual cell keratinization is also present (HE 40X).
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A 57-year-old male patient, treated for years for venous insufficiency and stasis dermatitis seek for medical advice for a small papule, surrounding by ulceration, within the limits of affected area, completely asymptomatic (Figure 3). Histologic report was in favour of squamous cell carcinoma (SCC)-Figure 3 and the patient was transferred to Oncology for further evaluation and treatment.
PMC7585506_04
Photo image: Large ulceration, covered with pus and necrotic tissue, localized within the area of a large ancient burn scar on the thorax. Histologic image: The tumor cells in the dermis have large, hyperchromatic nuclei and hypertrophic nucleoli often present. There is melanin present in the cells (HE 100X).
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Surgery Department for a large ulceration, covered with pus and necrotic tissue, localized within the area of a large ancient burn scar (Figure 4). Surgical treatment allowed sampling for histologic examination which concluded malignant melanoma (Figure 4).
PMC7585506_05
Photo image: Interscapular small scar and eczema-like lesion covered by crust. Histologic image: Nodular histologic (solid) basal cell carcinoma. Histological characteristics area similar to those described in photography number 1B. The epidermis is not ulcerated in this field. An inflammatory cell infiltrate is present (HE 40X).
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A 52-year-old female patient seeks for advice and treatment for a persistent pruritus and eczema-like lesion, covered by crust, localized in the interscapular area, close to a small scar of unknown origin (Figure 5). Histologic report described nodular histologic (solid) basal cell carcinoma (Figure 5).