PMC4052065_01
A submucosal swelling of the left subglottic trachea (arrow) by fiberscopic examination.
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The laryngeal mucosa did not appear to have an ulcerative or hemorrhagic lesion (Figure 1).
MRI revealed the same findings as CT scanning: (a) a low-intensity area on T1-weighted images and (b) a nonhomogenous high-intensity area on T2-weighted images. (c) The tumor demonstrates high intensity on a postgadolinium contrast T1 image (arrow).
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T1-weighted images (Figure 2(a)) and a nonhomogenous high-intensity area on T2-weighted images (Figure 2(b)). The images of the tumor demonstrated high intensity on a postgadolinium contrast T1 image (Figure 2(c)).
From behind, the laryngectomy specimen reveals a giant cell tumor under the intact mucosa (*). E: epiglottis, H: hyoid bone, T: trachea, VF: vocal fold, and scale bar = 3.0 cm.
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The interface between the tumor and the adjacent mucosa and the cartilage was clearly delineated (Figure 3).
(a) Histological examination demonstrates that the cellular mononuclear eosinophilic stromal component (arrowhead) and multinucleated osteoclast-like giant cells (arrow) were scattered throughout the lesions in an intermediate power field. Pleomorphic giant cells are absent. (b) Mitotic figures are about 6/10 HPF by the lack of cytological atypia.
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Histological examination revealed a cellular mononuclear eosinophilic stromal component, and multinucleated osteoclast-like giant cells were scattered throughout the lesion in an intermediate power field (Figure 4(a)). HPF by the lack of cytological atypia (Figure 4(b)). Histopathological findings yielded a diagnosis of "giant cell tumor with local invasion." The patient has been well following total laryngectomy and subsequently free of disease for two and a half years.