PMC10038002_01
A lesional skin biopsy from perianal giant CA showed: verrucous hyperplasia of squamous epithelium with Koilocyte cells (A) x40, (B) x100. Clinical manifestations before treatment (C). Elimination of giant perianal CA lesions after nearly 1 year's treatment with paiteling (D-G). No relapse appeared 10 months after the treatment finished (H).
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Physical examination of the perianal region revealed massive verrucous lesions surrounding the anus, hyperkeratotic and giving an aspect of a cauliflower, and contact bleeding test seemed positive (Figure 1C). A biopsy from fresh warts presented Koilocyte cells (Figure 1A and B). The therapeutic effect was satisfactory and achieved clinical recovery with no recurrence occurring thus far (Figure 1D-H).