PMC5156792_01
Computed tomography (CT) images, axial (a) and coronal (b), of the pelvis showing a huge mass involving bladder and rectum.
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Total body computed tomography (TBCT) (Figures 1(a)-1(b)) revealed a voluminous prostate gland (maximum diameter of 10 cm) heterogeneously enhancing the contrast medium.
68 Gallium DOTATATE PET/CT image showing a high and diffuse uptake of the prostate.
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A subsequent 68 Gallium DOTATATE PET/CT found a high uptake of the whole prostate (SUV max 12.7) and of the adjacent lymph nodes, confirming the presence of a neuroendocrine tumour in that site and excluding other distant metastases (Figure 2).
(a) Immunohistochemical stain showing tumour cell positive for ACTH (x40). (b) Immunohistochemical stain showing tumour cell positive for calcitonin (x20).
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The patient underwent a transurethral prostate biopsy that showed a small cell prostate cancer focally positive for ACTH and calcitonin and negative for chromogranin A and PSA at immunocytochemistry (Figures 3(a) and 3(b)).