PMC8267438_01
Histologic sections of involved occipital lobe. Luxol Fast Blue/PAS stain, Panel A (20X) and Panel B (40X), showing perivenous demyelination (pink areas around vessels) in areas of macrophage infiltration (arrowheads). Neurofilament protein stain demonstrates axonal preservation (arrows) in these areas, Panel C (40X) and Panel D (100X). Perivenous macrophage infiltration (arrows) is highlighted by CD68 immunohistochemistry, Panel E (40X) and Panel F (100X) (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article).
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C and Panel D). Perivenous macrophage infiltration was confirmed by CD68 and CD163 immunohistochemical stains (Fig. 1, Panel E and Panel F). CD3 and CD8 immunohistochemistry corroborated the presence of perivascular and parenchymal cytotoxic T lymphocytes, which were scant in comparison to the number of macrophages (data not shown).