PMC4719895_01
Microscopic image (100x) of the left ureter lined by normal urothelium (black arrow) and facing metastatic tumor nodule (white arrow) filling ureteral lumen. The tumor is composed of clear cells with classic architecture of alveolar nests and tightly packed tubules surrounded by delicate blood vessels. An immunohistochemistry with a sensitive and specific marker of renal tubular origin PAX8 showed diffuse nuclear staining of tumor and confirming morphologic impression of extra-renal metastasis of clear cell RCC, Fuhrman grade 2.
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Fuhrman grade 2/4 (Fig. 1). Final permanent surgical margins were free of carcinoma.