PMC4782402_01
(a) Smear reveals round to oval cells with hyperchromatic nuclei with a cell cluster showing deep cytoplasmic eosinophilia and dense compact chromatin (H and E, x40) (b) Tumor cells are forming epithelial pearl-like structure and a cell showing INCI (thin arrow) (H and E, x200) (c) Background population consists of lymphocytes and eosinophils (arrow) (H and E, x200)
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PMC4782402_01_JCytol-33-37-g001.jpg
F1
A few cell clusters showed squamoid differentiation in the form of pyknotic to densely compact nucleus and deeply orangophilic cytoplasm [Figure 1a]. At a few paces, the cells formed ill-defined epithelial pearl-like structures and only very occasionally the cells showed intranuclear cytoplasmic inclusion (INCI) [Figure 1b]. Background population comprised predominantly of lymphocytes and a significant number of eosinophils (1-2 cells/hpf) [Figure 1c].
(a) Histology showed island of squamoid cells embedded in a sclerotic stroma and dense eosinophil cell infiltrate (H and E, x100) (b) Normal thyroid parenchyma showed lymphocytic thyroiditis (H and E, x200) (c) Calcitonin negative (calcitonin, x200) (d) TTF-1 positivity (TTF-1, x200) (e) Thyroglobulin negative (thyroglobulin, x200) (f) Cytokeratin positive (cytokeratin, x200)
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F2
Histological diagnosis was further confirmed immunohistochemically as the tumor was positive for thyroid transcription factor-1 (TTF-1) and cytokeratin and negative for thyroglobulin and calcitonin [Figure 2].