PMC3234065_01
Histologic examination of the breast mass showed a high-grade carcinoma with pleomorphic nuclei and prominent nucleoli infiltrating predominantly in sheets with occasional glandular formations. A prominent lymphoplasmacytic infiltrate surrounds clusters of tumour cells. (Haematoxylin and eosin, x200)
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She underwent lumpectomy and sentinel node biopsy; the tumour was a 2.5-cm infiltrating ductal carcinoma with medullary features (Figure 1). Histologic examination of the lumpectomy specimen (Figure 1) shows a 1.4-cm invasive ductal adenocarcinoma with medullary features.
Histologic examination of the left-ovarian mass shows a histologic picture similar to the breast carcinoma with sheets of high-grade tumour cells surrounded by a lymphoplasmacytic infiltrate. Mitotic figures are easily identified. (Haematoxylin and eosin, x200)
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Subsequent sections confirmed the left ovary to be replaced by a metastatic cancer with medullary features (Figure 2), while the omental mass had classical features of papillary serous cancer (Figure 3). Microscopically, the left ovary showed a high-grade adenocarcinoma composed of sheets of tumour cells with a predominantly solid pattern and focal glandular differentiation (Figure 2).
Histologic examination of the omental mass shows tumour cells arranged in papillary groupings with numerous psammoma bodies. A lymphoplasmacytic infiltrate is not seen. (Hematoxylin and eosin, x200)
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Subsequent sections confirmed the left ovary to be replaced by a metastatic cancer with medullary features (Figure 2), while the omental mass had classical features of papillary serous cancer (Figure 3). The omental mass showed a different histologic picture with a papillary growth pattern (Figure 3), a lack of a lymphoplasmacytic infiltrate and numerous psammoma bodies diagnostic of a papillary serous adenocarcinoma.