PMC5816871_01
Peripheral smear showing frequent elliptocytes, tear drop cells, schistocytes, and occasional spherocytes.
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fig1
Peripheral smear in Figure 1 shows frequent elliptocytes, teardrop cells, schistocytes, and occasional spherocytes.
A bone marrow aspirate (a) and core biopsy (b) showing a hypercellular marrow with trilineage dyspoiesis and associated erythroid hyperplasia without any fibrosis.
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fig2
A bone marrow aspirate and core biopsy in Figure 2 show a hypercellular marrow with trilineage dyspoiesis and associated erythroid hyperplasia without any fibrosis.
Iron staining before treatment showing increased storage and sideroblastic iron with few ring sideroblastic iron.
CRIHEM2018-6819172.003.jpg
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fig3
Peripheral smear showing improvement in elliptocytosis after completion of 6 cycles of treatment with azacytidine.
CRIHEM2018-6819172.004.jpg
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fig4
Patient has been independent of any supportive transfusions, and repeat bone marrow biopsy after completion of 6 cycles showed complete cytogenetic remission as well as significant improvement in elliptocytosis as shown in Figure 4.