PMC5337871_01
Gross image of right ovarian solid and multicystic mass which measured 27.0 x 17.0 x 5.0 cm. The capsular surface showed a 4.0 x 2.0 cm area of disruption (blue arrow). A 4.3 x 3.0 x 0.6 cm solid area was also noted (red arrow).
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fig1
Some cyst walls were focally lobulated and one cyst wall demonstrated a 4.3 x 3.0 x up to 0.6 cm tan-brown solid area (Figure 1).
Sections from the tumor show networks of anastomosing slit-like to cystic spaces lined by cuboidal Sertoli cells, resembling the rete testis. Some of the retiform tubules are denoted by blue arrows (H&E, 100x).
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fig2
Areas with irregular networks of elongated, slit-like tubules, and papillae with fibrotic cores lined by Sertoli cells arranged in an architectural pattern resembling the rete testis were also noted in sections from the solid area (Figures 2-5).
Another section of the tumor demonstrates sheets of Sertoli cells. Within the sheets of Sertoli cells, areas of small tubular formation can be seen. Clusters of Leydig cells are also noted (blue arrows) (H&E, 100x).
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fig3
Areas with irregular networks of elongated, slit-like tubules, and papillae with fibrotic cores lined by Sertoli cells arranged in an architectural pattern resembling the rete testis were also noted in sections from the solid area (Figures 2-5).
A section of the tumor shows the solid component of the tumor composed of Sertoli cells. Small tubular formation is noted in the solid component. Cuboidal Sertoli cells line the slit-like spaces (H&E, 200x).
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fig4
Areas with irregular networks of elongated, slit-like tubules, and papillae with fibrotic cores lined by Sertoli cells arranged in an architectural pattern resembling the rete testis were also noted in sections from the solid area (Figures 2-5).
Image of the tumor demonstrating the merging of the solid component composed of Sertoli cells with the Sertoli cells lining the slit-like spaces (H&E, 400x).
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fig5
Areas with irregular networks of elongated, slit-like tubules, and papillae with fibrotic cores lined by Sertoli cells arranged in an architectural pattern resembling the rete testis were also noted in sections from the solid area (Figures 2-5).
Immunohistochemical profile of the tumor for pancytokeratin, beta-catenin, calretinin, and inhibin (20x).
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fig6
Images with the staining patterns of the tumor for inhibin, calretinin, beta-catenin, and pancytokeratin are presented in Figure 6.
Nuclear and cytoplasmic beta-catenin positivity in retiform areas and focal solid areas composed of sheets of Sertoli cells (200x).
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fig7
Images showing nuclear and cytoplasmic beta-catenin positivity in Sertoli cells, retiform areas, and Leydig cells are shown in Figures 7, 8, and 9, respectively.
Beta-catenin with nuclear and cytoplasmic positivity in retiform areas (400x).
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fig8
Images showing nuclear and cytoplasmic beta-catenin positivity in Sertoli cells, retiform areas, and Leydig cells are shown in Figures 7, 8, and 9, respectively.
Beta-catenin with nuclear and cytoplasmic positivity in Leydig cells (400x).
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fig9
Images showing nuclear and cytoplasmic beta-catenin positivity in Sertoli cells, retiform areas, and Leydig cells are shown in Figures 7, 8, and 9, respectively.