PMC8049140_01
Clinical course of the patient before desensitization and under long-term therapy with colomycin. (A) FEV1 trend before desensitization with colomycin, years 2006-2010. (B) FEV1 trend after desensitization with colomycin and under regular, twice daily nebulized colomycin therapy, years 2010-2015. (C) Concentration of Pseudomonas strains in years 2008-2015-before and after desensitization. (D) Number of antibiotic courses in years 2002-2019-before and after desensitization. D-Desensitization: 06.2010.
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F1
The clinical condition improved significantly, the lung function trend was stable, the microbiological findings of Pseudomonas aeruginosa were reduced to 103 cells/ml, also the number of oral and intravenous antibiotic courses could be reduced as well as the number of hospital admissions due to pulmonary exacerbations (Figure 1).