PMC9424543_01
(A) Insignificant pathological findings in H&E staining and direct immunofluorescence staining. Scale bar: 100 mum. (B) Extensive podocyte foot process effacement (arrow) in patient's kidney biopsied samples. (Electron microscopy image).
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F1
Pathology revealed no glomerular lesion or tubular injury and no immune deposits; however, extensive podocyte effacement and microvilli transformation confirmed an MCD diagnosis (Figure 1).
Illustration of the disease course by showing daily protein loss and serum albumin levels of the patient after 2 weeks of the second dose of the Moderna COVID-19 vaccine. Week 0: start prednisolone treatment (1 mg/kg/day).
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F2
The patient achieved partial remission (50% reduction from the initial value of 24-h urine protein) at 2 weeks and complete remission (urine protein excretion < 0.3g/day) at 10 weeks of steroid use (Figure 2).