PMC9876767_01
Image characteristics in the present case. CT- scan of the abdomen and pelvis revealed a mass with a size of 36x34 mm in the distal common bile duct (CBD) between segments 4 and 5 of the liver (A). Microscopically (hematoxylin and eosin (HE) 100), the tumor is composed of squamous cells with nonkeratinization (B). Positron emission tomography-computed tomography showed a hypermetabolic mass with a size of 26x28 mm involving the edge of the lobectomy site (C)
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F1
No other mass was observed in the abdomen o pelvis (Figure 1A). Hematoxylin-eosin staining (H&E) of the liver mass showed infiltrating features with squamoid cells and varying degrees of differentiation and atypia (Figure 1B). Because of the patient's abdominal pain, a positron emission tomography (PET) scan was performed six weeks after surgery that showed a hypermetabolic mass 26x28 mm in size involving the edge of the lobectomy site with SUVmax=10.8, indicating recurrence (Figure 1C).
IHC analysis showed that CK8, CK18, CK7, CK20, GCDFP-15, and HepPar-1 staining were negative, but p63 expression was positive
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F2
Cytokeratin (CK)7, 8, 18, 20 (-) and gross cystic disease fluid protein (GCDFP-15) were negative, but P63 was positive (Figure 2).