PMC9910202_01
Computed tomography scan showing an enhanced mass located in the left submandibular gland. Red arrows: sebaceous carcinoma mass (A). Ultrasound examination revealed a mixed-component nodule in the left submandibular gland (B).
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A nodular lesion in the left submandibular gland was observed with a diameter of approximately 1.2 cm, uniform reinforcement, and clear boundary (Figure 1A). Ultrasound examination revealed a mixed-component nodule in the left submandibular gland (Figure 1B).
((A) x200) Hematoxylin and eosin staining showing tumor cell nests infiltrating into the salivary gland tissues. Malignant cells show prominent nucleoli, nuclear atypia, and foamy cytoplasm. ((B) x400) Perineural invasion was present in the tumor tissue. ((C) x400) Immunohistochemical examination showed: negative staining for androgen receptor; ((D) x400) positive staining for CK7; ((E) x400) positive staining for epithelial membrane antigen (EMA) in focal areas; ((F) x400) negative staining for GCDFP; ((G) x400) KI-67 index of approximately 15%; ((H) x400) positive staining for MLH1; ((I) x400) positive staining for P63; ((J) x400) negative staining for S-100.
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Malignant cells were characterized by pleomorphic nuclei with prominent nucleoli and a moderate number of mitoses in the foamy cytoplasm (Figure 2A). There was evidence of perineural invasion (Figure 2B), but no significant vascular invasion was observed. The tumor was negative for androgen receptor (AR), CEA, S-100, CK5/6, BCL-2, SOX-10, SOX-11, SMA, CD117, DOG-1, Galectin-3, GCDFP-15, and GFAP (Figure 2C-J). 