PMC3684318_01
Biochemical and viral serological markers during the course of the disease, before and after the introduction of tenofovir. ALT, Alanine aminotransferase (U/L); INR, International normalized ratio; HBsAg, hepatitis B surface antigen; HBeAg, Hepatitis B e antigen; Anti-HBc IgM, anti-hepatitis B core IgM antibody; HBV DNA, Hepatitis B DNA; Anti-HBs, anti-hepatitis B surface antibody.
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AHB (clinical encephalopathy was not present), antiviral therapy with lamivudine 100mg daily was then added. A dramatic improvement in liver enzymes and INR was observed, however this was only sustained for the first 9 days (total bilirubin decreased to 5.5mg/dL, ALT 1237U/l and INR 1.15) (Figure 1). Total normalization of the liver biochemical parameters was achieved after 3 months (Figure 1).