PMC9932521_01
Patient case history and tumor histology. (A) Case history, outlining clinical progression, therapy and surgery history, and blood marker profiles. (B) H&E staining of patient tumor tissue (third surgery), PDX, organoid and 2D cells culture, as indicated. Signet ring cells are highlighted by black arrows (20X magnification).
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The clinical history of this case is summarized in  Figure 1A .