PMC3595975_01
Renal pathology of DIC in association with metastatic prostate cancer. The peripheral glomerular capillaries (A) and afferent arteriole (B, arrows) were distended by thrombi formation (periodic acid methenamine silver stain). Fibrin strands revealed by phosphotungstic acid hematoxylin stain constituting the thrombi (C). The presence of sparsely scattered platelets within the thrombi was detected by immunostaining with an anti-CD41 antibody (D). Focal segmental sclerosis of the glomeruli (E and F; periodic acid methenamine silver stain). Segmental sclerosis of capillary architecture associated with attachments to the Bowman's capsule with prominence of overlying epithelial cells (E, arrows). Segmental sclerosis was also noted at the urinary pole with capillary lumina obliterated by infiltration of mononuclear leukocytes and foam cells (F, arrowhead).. Notes: Original magnification: x200. Scale bars: 100 muM.
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The vast majority of the remaining glomeruli showed numerous thrombi formation mainly involving peripheral glomerular capillaries and afferent arterioles, reflective of severe coagulation disorder (Figure 1A and B). A phosphotungstic acid hematoxylin stain identified dark blue fibrin strands constituting the thrombi (Figure 1C). CD41 immunostaining showed the presence of sparsely scattered platelets within the thrombi (Figure 1D). The FSGS was characterized by segmental sclerosis of capillary architecture associated with attachment to Bowman's capsule, accompanied by the prominence of overlying epithelial cells (Figure 1E). Another glomerulus exhibited the segmental obliteration of a few capillaries by infiltration of mononuclear leukocytes and foam cells, and attachment to Bowman's capsules near the urinary pole (Figure 1F).