PMC10028179_01
Brain MRI showing the two brain metastases, the right frontal (3 mm) and the left occipital one (18 mm). GTV was the T1-gadolinium enhanced lesion while PTV was defined as GTV + 3 mm.
fonc-13-1136300-g001.jpg
PMC10028179_01_fonc-13-1136300-g001.jpg
f1
In October 2021, brain MRI revealed two brain metastasis, one was in the right frontal lobe (3 mm) and the other in the left occipital lobe (18 mm), both associated with extensive brain edema ( Figure 1 ).
Impressive volume reduction of two brain radionecrosis areas. (A) Left occipital lesion. Above, MRI before cabozantinib (9 months after SRS). Below, MRI after cabozantinib (13 months after SRS). (B) Right frontal lesion: Above, MRI before cabozantinib (9 months after SRS). Below, MRI after cabozantinib (13 months after SRS).
fonc-13-1136300-g002.jpg
PMC10028179_01_fonc-13-1136300-g002.jpg
f2
After only 2 months from second-line systemic therapy, the brain MRI showed excellent reduction of the two areas of brain radionecrosis with a surprising shrinkage of the associated edema ( Figure 2 ).