PMC9853382_01
Headache VAS score (black), BDG assay (blue), CSFP (orange), mNGS SSRN (green). The treatment course: voriconazole iv for 4 weeks, but both of mNGS SSRN and CSFP increase, so intrathecal and intravenous amphotericin B were added, combined with voriconazole, for 8 weeks. Then voriconazole po for a year. VAS: visual analogue scale, BDG: (1-3)-beta-D-glucan, CSFP: cerebrospinal fluid pressure, mNGS: metagenomic next-generation sequencing, SSRN: species-specific read number, iv: intravenous injection, po: per os, it: intrathecal injection.
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PMC9853382_01_fcvm-09-1042631-g001.jpg
F1
The intracranial pressure gradually decreased to normal, the G test result turned negative, and repeated mGNS tests of the CSF became negative (see Figure 1 for the specific treatment course).