PMC8077407_01
Histopathological examination of the primary leptomeningeal glioblastoma. a Prominent tumor cell infiltrate in the subarachnoid space and reactive astrogliosis in the brain parenchyma. x20. Hematoxylin and eosin. b The astrocytic tumor cells are positive for glial fibrillary acid protein. x40. c Nearly all tumor cells are positive for the oncoprotein p53. x10. d The p53-positive tumor cells are spreading through the Virchow-Robin spaces throughout the brain. x40.
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F1
A diffuse, malignant, astrocytically differentiated leptomeningeal glioma was found in the overlying meninges, compatible with a primary leptomeningeal glioblastoma of a diffuse type (WHO grade IV, IDH wild type) with tumor infiltration of the cerebral parenchyma and the cerebellar cortex (Fig. 1).