PMC7399333_01
Histochemical and immunohistochemical examinations of the tumor from our case. (A) LCNEC of the bladder showed large cells with large nuclear size, prominent nucleoli, and abundant cytoplasm. (H&E staining, x400). The neoplasm displayed positive expression of CgA (B), strong and diffused expression of Syn (C), absent NSE expression (D), positive for CD56 (E), and the proliferative index Ki67 was 90% (F). A final diagnosis of LCNEC was performed. LCNEC, large cell neuroendocrine carcinoma; H&E, hematoxylin and eosin; CgA, Chromogranin A; Syn, synaptophysin; NSE, neuron specific enolase.
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F1
The pelvis CT revealed a suspicious mass addressing the anterior right wall of bladder (41 mm x 34.8 mm x 31.0 mm) with multiple high-density calcification lesions (Supplementary Figure 1). As seen in Figure 1, immunohistochemical analysis showed the neoplastic cells were positive for neuroendocrine markers like: chromogranin A (CgA), synaptophysin (Syn), and CD56.