PMC4361913_01
Time course of the plasma concentration during gefitinib (250 mg/day) administration in the present case. The gefitinib concentration increased to 626.6 and 670.0 ng/ml (before and 12 h after dosing, respectively) on day 16. On day 46, the concentration was 538.4 ng/ml at the trough level and 609.2 ng/ml 12 h after the administration of gefitinib. The plasma concentration of gefitinib had reached the steady state by day 16 at the latest.
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F1
Thus, we concluded that the plasma concentration of gefitinib had reached the steady state by day 16 at the latest (fig. 1).