PMC5421196_01
Schematic diagram of T2-weighted axial (a) and coronal (b) images revealing a nonenhancing hyperintense lesion in the right mesial temporal lobe. Axial (c) and coronal FLAIR sequences (d) showing a hyperintense lesion in the white matter of the right mesial temporal lobe
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F1
The lesion appeared hyperintense on T2-weighted images [Figure 1a and b]. Fluid-attenuated inversion recovery (FLAIR) sequences delineated a nonspecific hyperintense focus in the right temporal lobe near the gray-white interface [Figure 1c and d].
Schematic diagram of a 20x magnification of H and E stained specimen revealing polyglucosan bodies (a) and 20x magnification of CA stained pink with periodic-acid Schiff staining (b)
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F2
Permanent section H and E slides [Figure 2a] also demonstrated the presence of numerous polyglucosan bodies, far in excess of those found in the normal aging brain. Periodic-acid Schiff stain highlighted the polyglucosan bodies [Figure 2b], providing a final diagnosis of a dense CA lesion.