PMC6662440_01
A large ulcerated 3 x 3 cm tumor on the extensor surface of the left thigh at presentation (a); a widespread erythematous papulonodular eruption involving the face, the trunk and the extremities with occasional scaling at the periphery of the lesions (b).
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fig1
On physical examination there was a nodular, incipiently ulcerated, crumbly lesion 3 x 3 cm in dimension on the extensor surface of the left thigh, as well as crops of multiple elevated dome-shaped nodules and papules of reddish color and shiny, smooth surface on the trunk, the upper and lower extremities, the neck, periorbital and on the genitalia (Figures 1(a) and 1(b)).
Histology revealed a diffuse lymphocytic infiltration in the reticular dermis by small, medium, and large sized lymphocytes, some of which with anaplastic nuclei, accompanied by a variable number of neutrophils and histiocytes (hematoxylin-eosin stain x 20 (a), x 40 (b), x 60 (c)).
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Histology revealed a diffuse lymphocytic infiltration in the reticular dermis by small, medium, and large sized lymphocytes, some of which with anaplastic nuclei, accompanied by a variable number of neutrophils and histiocytes (Figures 2(a)-2(c)).
Immunophenotypically the lymphocytes were CD3+ (x20) (a) and >75% CD30+ (x40) (b) and (x60) (c) (Immunohistochemistry with Envision Detection System Peroxidase/DAB, Rabbit/Mouse).
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Complete remission of the eruption leaving depressed scars, including the previous tumor on the left thigh (a) and the papulonodular eruption at other body sites (b).
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Of notice was the regression of the ulcerated nodular lesion on the left thigh (Figures 4(a) and 4(b)).