PMC9626822_01
A timeline showing symptoms and exams/interventions performed on the patient. AOSD, Adult-onset Still's disease; CRP, C-reactive protein; LDH, lactate dehydrogenase, ESR, erythrocyte sedimentation rate.
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F1
The lymph node ultrasound revealed extensive enlarged superficial lymph nodes (Figure 1). We performed the electrophysiological examination, and nerve and muscle biopsy revealed immune-mediated extensive peripheral nerve injury (Supplementary Figures 1-3).
Patient's photograph of the sural nerve biopsy specimen. Electron microscopic findings: Myelinated nerve fibers were extensively destroyed. Wallerian degeneration could be observed (white star), and Schwann cells and macrophages were not observed. Scale bars: 2mum.
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F2
We performed the electrophysiological examination, and nerve and muscle biopsy revealed immune-mediated extensive peripheral nerve injury (Supplementary Figures 1-3). Intriguingly, electron microscopy images of nerve biopsy demonstrate the typical manifestation of distal axonal degeneration due to nerve injury:Wallerian degeneration (Figure 2).