PMC3014742_01
PMC3014742_02
(a) Actinic keratosis and multiple squamous cell carcinomas of photo-exposed areas induced by voriconazole. (b) Microinvasive squamous cell carcinoma. Epithelial proliferation composed of atypical keratinocytes infiltrating the dermis, magnification x200. (c) Actinic keratosis hyperkeratosis, slightly atypical epidermal hyperplasia; magnification x200.
CRIM2010-351084.001.jpg
PMC3014742_02_CRIM2010-351084.001.jpg
fig1
In August 2006, while the patient was still receiving voriconazole, multiple erosive and keratosic lesions of photo-exposed areas appeared, associated with erythema of the back of hands (Figure 1(a)). Subsequently, 17 squamous cell carcinomas and multiple actinic keratoses (Figures 1(b) and 1(c)) on the face and scalp were diagnosed up to December 2008 at which time voriconazole was discontinued.