PMC4337497_01
Macroscopic findings of the stomach. Hemorrhagic fluid contained many gray-white drug particles. The gastric mucosa showed diffuse hemorrhage.
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Examination of her organs revealed her heart weighed 210 g and had no observable coronary artery abnormalities, her brain weighed 1,540 g and looked edematous, her left and right lungs weighed 130 g and 160 g, respectively, and there was 135 g of gastrointestinal contents, which contained many drug particles (Fig. 1).
Histopathology of the stomach, heart, and lung. (a) Gastric erosion with hemorrhage. Inflammatory cell infiltration is not seen because of the early phase of the lesion. (b) Edematous change of the cerebrum. Note the submeningeal and perivascular area. (c) No caffeine-related changes are observed in the heart. (d) No caffeine-related changes are observed in the lungs. H & E staining, x200.
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While mild erosion of the stomach with hemorrhage (Fig. 2a) and brain edema (Fig. 2b) were seen, there were nonspecific changes in many of the organs, including the heart (Fig. 2c), lungs (Fig. 2d), liver and kidneys.