PMC8633869_01
PMC8633869_02
MRI brain prior to starting chelation showing high T1 signal sequentially in basal ganglia, especially globus pallidus (A) and midbrain (B).
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PMC8633869_02_gr1b.jpg
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He underwent a brain MRI (magnetic resonance imaging) with and without contrast which demonstrated T1 hyperintense signal in basal ganglia (particularly globus pallidus), cerebral peduncles, midbrain, dorsal pons, superior cerebellar peduncles, dentate nuclei and cerebellar white matter (Fig. 1).
PMC8633869_03
MRI brain obtained 9 months after starting chelation showing resolution of T1 signal sequentially in globus pallidus (A) and midbrain (B).
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PMC8633869_03_gr2b.jpg
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A repeat brain MRI obtained 9 months after starting chelation, showed nearly complete resolution of the hyperintense signal in the globus pallidus and other aforementioned regions related to manganese deposition (Fig. 2).