PMC8129544_01
Midsagittal (FLAIR sequences) slices show selective midbrain tegmentum atrophy with "Hummingbird sign" (flattening of the superior aspect of the midbrain tegmentum) in both patients. Axial slices (FLAIR sequences) additionally show a "Mickey Mouse sign" (reduction of the anteroposterior midline midbrain diameter) in patient 1 (A) and an incipient "Morning Glory sign" (loss of the lateral convex margin of the midbrain tegmentum) in patient 2 (B), all of which are highly suggestive of PSP. Atrophy is also noted in the superior medial frontal cortex affecting the pre-supplementary motor area and the supplementary motor area, but the cingulate gyrus and the orbitofrontal cortex are preserved. Moderate atrophy of the body of the corpus callosum is seen in patient 1.
fnagi-13-635896-g001.jpg
PMC8129544_02_fnagi-13-635896-g001.jpg
F1
A brain MRI showed moderate cortical, subcortical, and midbrain tegmentum atrophy (Figure 1).
PMC8129544_02
Midsagittal (FLAIR sequences) slices show selective midbrain tegmentum atrophy with "Hummingbird sign" (flattening of the superior aspect of the midbrain tegmentum) in both patients. Axial slices (FLAIR sequences) additionally show a "Mickey Mouse sign" (reduction of the anteroposterior midline midbrain diameter) in patient 1 (A) and an incipient "Morning Glory sign" (loss of the lateral convex margin of the midbrain tegmentum) in patient 2 (B), all of which are highly suggestive of PSP. Atrophy is also noted in the superior medial frontal cortex affecting the pre-supplementary motor area and the supplementary motor area, but the cingulate gyrus and the orbitofrontal cortex are preserved. Moderate atrophy of the body of the corpus callosum is seen in patient 1.
fnagi-13-635896-g001.jpg
PMC8129544_02_fnagi-13-635896-g001.jpg
F1
A brain MRI showed moderate cortical, subcortical, and midbrain tegmentum atrophy (Figure 1).