PMC4038865_01
Magnetic resonance imaging scan showing an intramedullary well-circumscribed hemorrhagic lesion involving the spinal cord at the D9-D10 level, showing no significant postcontrast enhancement
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F1
Associated cord edema is seen from the D5 to the D12 level [Figure 1].
H and E, x40: Sheets and nests of cells with marked pigment deposition
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F2
On microscopic examination of the hematoxylin and eosin-stained slides, a lesion was seen showing sheets and nests of cells with marked pigment deposition [Figure 2].
H and E, x400: Cells with moderate cytoplasm and oval to elongated nuclei
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F3
It showed cells with moderate cytoplasm and oval to elongated nuclei [Figure 3].
Perl's stain x100: Negative for iron
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F4
Perl's stain for iron was negative [Figure 4].
HMB 45 x100: Positive
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F5
S-100 x100: Positive
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F6
EMA x100: Negative
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F7
Melan-A, while they were negative for CK, EMA [Figure 7], CD34 [Figure 8], GFAP and NSE. Mib-1 labeling index was less than 1% [Figure 9].
CD34 x100: Negative
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F8
Melan-A, while they were negative for CK, EMA [Figure 7], CD34 [Figure 8], GFAP and NSE. Mib-1 labeling index was less than 1% [Figure 9].
Ki-67 x100: Very low
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F9
Melan-A, while they were negative for CK, EMA [Figure 7], CD34 [Figure 8], GFAP and NSE. Mib-1 labeling index was less than 1% [Figure 9].