PMC6721453_01
(a) Dermal infiltration of neutrophils of Sweet's syndrome, (b) bone marrow trephine demonstrating hairy cell leukemia infiltration, and (c) bone marrow trephine immunohistochemistry for CD20.
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fig1
A skin biopsy demonstrated dermal neutrophils producing upper dermal edema and a subepidermal blister consistent with bullous Sweet's syndrome (acute febrile neutrophilic dermatosis) (Figure 1(a)). Trephine biopsy demonstrated an infiltration of hairy cells with typical morphology (Figure 1(b)) with immunohistochemistry of these hairy cells demonstrating positivity for CD10, CD20, CD25, CD72, and BCL2 (Figure 1(c)).