PMC6886270_01
Painful ulcerated nodules on the inferior limbs slowly progressing over a 7-month period.
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A 73-year-old woman presented with a history of painful ulcerated nodules on lower limbs slowly progressing over a 7-month period (Figure 1).
Amyloid deposits deep in the dermis and subcutaneous fat on H&E.
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Skin biopsy of lesions revealed amyloid deposits deep in the dermis and subcutaneous fat (Figure 2) (Figure 3).
Amyloid deposit on thioflavine immunofluorescence.
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Skin biopsy of lesions revealed amyloid deposits deep in the dermis and subcutaneous fat (Figure 2) (Figure 3).
Plasma cell perivascular infiltrate on H&E. Monotypic kappa light-chain restriction was observed on immunohistochemistry.
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Monoclonal plasma cells were found around blood vessels, and monotypic kappa light-chain restriction was observed (Figure 4).