PMC5818906_01
PMC5818906_02
PMC5818906_03
Clinical aspects (patient 3). (a) Lesion on R thigh, recurrence after initial resection. (b) The same patient three years later (a few months before his death).
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fig1
The lesion was located on the right thigh (Figure 1(a)) and clinically resembled BU or a soft tissue tumor. The lesion extended to the whole right lower limb with a pseudoelephantiasis aspect (Figure 1(b)), and the skin ulcerated on the calf.
Histopathology of basidiobolomycosis. (a) Granulomatous inflammation with eosinophils and multinucleated giant cells in the subcutaneous tissue. Hematoxylin-Eosin, 50x. (b) Granulomatous inflammation with eosinophils cells and septate hyphal fragments. Hematoxylin-Eosin, 100x. (c) Granulomatous inflammation with eosinophils, multinucleated giant cells, and the Splendore-Hoeppli phenomenon. Hematoxylin-Eosin, 100x. (d) Septate hyphal fragments (arrow). Gomori-Grocott staining, 400x.
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fig2
Histopathological results after HE staining of all three cases showed tuberculoid granulomata with giant cells (Figure 2(a)), numerous lymphocytes, histiocytes and eosinophilic cells (Figure 2(b)), an amorphous eosinophilic material also known as the "Splendore-Hoeppli phenomenon" (Figure 2(c)), and 10 mum diameter septate hyphal fragments (Figure 2(b)), confirmed also by the Gomori-Grocott staining (Figure 2(d)).