PMC3934073_01
Numerous gray and brown papules in the axillary area
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F0001
The patient reported pain in the oral cavity on ingestion of sour or hot food (Figs. 1 and 2).
Lesions on mucous membranes in the course of acanthosis nigricans
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F0002
The patient reported pain in the oral cavity on ingestion of sour or hot food (Figs. 1 and 2).
Vitiligo lesions on the neck and back
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F0003
In addition, many vitiligo spots were detected on the back, cleavage, dorsal surface of the hands and on the face (Fig. 3).
Histologic examination reveals hyperkeratosis, papillomatosis with minimal or no acanthosis or hyperpigmentation.. The dermal papillae project upward as fingerlike projections and correlate with the clinical picture (H+E staining, magnification 40x)
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F0004
A skin specimen collected from the right axillary was evaluated by the pathologist: skin covered with acanthotic epidermis and hypertrophic skin papilla - suspicion of acanthosis nigricans (Fig. 4).