PMC3516128_01
FNA cytology, Case 1. (A) Low magnification shows several sheets of follicular cells with some singly scattered oval-shaped tumor cells within a background of abundant bluish mucin (Papanicolaou stain). (B) High magnification shows the tumor cells having abundant cytoplasm and vesicular nuclei with nuclear inclusions (Papanicolaou stain). Inset indicates nuclear inclusions. (C) Microfollicles of tumor cells show irregular nuclei and rare mitotic figures. (D) Intracytoplasmic vacuoles compressing cell nuclei are rarely found (Papanicolaou stain).
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FNA taken from the right lobe showed many singly scattered discohesive cells and occasional clusters had scanty to abundant granular cytoplasm in a mixed sticky mucin and colloidal background (Fig. 1A). Frequent nuclear inclusions and rare mitoses with atypical forms were found (Fig. 1B and C). Rare intracytoplasmic vacuoles were also found (Fig. 1D).
(A-D) Case 1. (A) Grossly, the thyroid nodule is ovoid and shows a greenish to brown-colored mucoid cut surface. (B) On light microscopy, the oval-shaped mass is encapsulated by a well-formed thick capsule and contains abundant extracellular mucin. (C) Some tumor cells of the microfollicles contain mucinous material. Arrow indicates nuclear clearing and inclusions (right: thyroglobulin immunostain). (D) Microfollicles of tumor cells show nuclear irregularities and nuclear inclusions (inset). (E and F) Case 2. (E) The thyroid nodule shows trabecular arrangements of oval shaped tumor cells in abundant myxoid stroma. (F) High magnification of this lesion shows spillage of extracellular mucin and irregular nuclei with nuclear inclusions (inset).
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Microscopically, the tumor was composed of anastomosing cords and trabeculae of polygonal cells with intervening amyloid-like extracellular eosinophilic stroma and bluish mucinous material (Fig. 2E). Some areas of the first case's lesion showed nuclear irregularities with frequent inclusions, whereas Case 2 showed nuclear irregularities with occasional intranuclear inclusions (Fig. 2F).
PMC3516128_02
(A-D) Case 1. (A) Grossly, the thyroid nodule is ovoid and shows a greenish to brown-colored mucoid cut surface. (B) On light microscopy, the oval-shaped mass is encapsulated by a well-formed thick capsule and contains abundant extracellular mucin. (C) Some tumor cells of the microfollicles contain mucinous material. Arrow indicates nuclear clearing and inclusions (right: thyroglobulin immunostain). (D) Microfollicles of tumor cells show nuclear irregularities and nuclear inclusions (inset). (E and F) Case 2. (E) The thyroid nodule shows trabecular arrangements of oval shaped tumor cells in abundant myxoid stroma. (F) High magnification of this lesion shows spillage of extracellular mucin and irregular nuclei with nuclear inclusions (inset).
ccrep-5-2012-155f2b.jpg
PMC3516128_02_ccrep-5-2012-155f2b.jpg
f2-ccrep-5-2012-155
Microscopically, the tumor was composed of anastomosing cords and trabeculae of polygonal cells with intervening amyloid-like extracellular eosinophilic stroma and bluish mucinous material (Fig. 2E). Some areas of the first case's lesion showed nuclear irregularities with frequent inclusions, whereas Case 2 showed nuclear irregularities with occasional intranuclear inclusions (Fig. 2F).