PMC10108403_01
Color Doppler ultrasound of enlarged lymph nodes in groin and neck.
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Color Doppler ultrasound of enlarged lymph nodes in groin and neck (Figure 1).
Hematoxylin and eosin(H&E x 200) straining shows the nodal architecture effacement by diffuse sheets of histiocytes with abundant eosinophilic cytoplasm and surrounding lympho-plasmacytic infiltrate (a). The areas where the histiocytes engulf intact chronic inflammatory cells are called emperipolesis (red arrows) (b).
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The pathological examination results were as follows: histiocyte-like cells significantly proliferated with multiple plasma cell infiltration and interstitial fibrosis (Figure 2). Immunohistochemical staining: plasma cell IgG (+), IgG4 (partial +, < 100 /HPF), IgG4 < IgG < 40%, CD38 (+), CD138 (+), K (dominant +), lambda (partial +), residual follicular CD20 (+), interstitial CD3 (+), histiocytic like cells CD1a (-), langerin (-), S-100 (+), CD163 (+) (Figure 3), and penetration phenomenon (Figure 2).
(immunohistochemistryX200) shows the characteristic histiocytes were strongly positive for S-100 protein (a) and CD163 (b).
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Immunohistochemical staining: plasma cell IgG (+), IgG4 (partial +, < 100 /HPF), IgG4 < IgG < 40%, CD38 (+), CD138 (+), K (dominant +), lambda (partial +), residual follicular CD20 (+), interstitial CD3 (+), histiocytic like cells CD1a (-), langerin (-), S-100 (+), CD163 (+) (Figure 3), and penetration phenomenon (Figure 2).