PMC6549525_01
(A) Depiction of the history of a 19-year-old patient with urothelial carcinoma and (B) (20X magnification) Hematoxylin and Eosin stained section (i) showing a high-grade urothelial carcinoma with plenty of large pleomorphic cells; (ii,iii) showing a high-grade urothelial carcinoma infiltrating the detrusor muscle.
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F1
An overview of the medical disease history is illustrated in a timeline (Figure 1A). Photomicrographs of the tumor from the urinary bladder showed a high-grade urothelial carcinoma with plenty of large pleomorphic cells and infiltrating the detrusor muscle (Figure 1B). WES data analysis revealed 558 exonic somatic mutations, of which 360 missense, 26 nonsense, 30 frameshift deletions/ insertions and, also 10 splice site mutations were annotated (Supplementary Figure 1).