PMC8371466_01
Chronic inflammation and immune activation: a delicate balance.
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As known, inflammation plays a key role in oncogenesis (Figure 1).
The pathogenetic role of HIV.
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Moreover, HIV could determine microsatellite gene instability and genetic alterations, promoting formation of different cancers, including NMSCs (Figure 2).
The exploration of a bond between NMSCs and immuno-viral profile of PLWH.
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A peculiar correlation between decreased immune-surveillance and carcinogenic virus co-infections might favor oncogenesis, increasing the risk of developing tumors in these subjects (see Figure 3).