PMC3979789_01
Electrophoresis of serum (A) and urine (B). The arrow in the urine electrophoresis indicates the pathological homogenous component that accounted for 53.3% of the urinary proteins in the beta-fraction.
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The electrophoretic analysis of the serum and urine proteins is shown in Figure 1. The serum electrophoresis pattern showed decreased albumin and increased alpha1-fraction, beta-fraction, and gamma-globulins, suggesting polyclonal gammopathy (Figure 1A). The urine electrophoresis showed increased beta-fraction, which accounted for 53.3% of the urinary proteins (Figure 1B).
Thigh muscle biopsy.. Notes: (A) Inflammatory cells invading the endomysium within the muscle fascicles (arrows). Hematoxylin and eosin stain (x200 magnification). (B) Immunohistochemical staining for CD8. Activated CD8+ T cell lymphocytes have infiltrated the vastus lateralis muscle (x100 magnification, brown color, arrows).
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Biopsy of the left vastus lateralis muscle demonstrated endomysial chronic inflammation and muscle fiber necrosis (Figure 2A), and immunohistochemical stain showed infiltration by CD8+ T cells (Figure 2B).