PMC6000912_01
(a) Light microscopy. Hematoxylin and stain. Significant endocapillary proliferation with neutrophils and swollen endothelial cells. (b) Jones stain with occasional double contour. No evidence of significant crescents noted. (c) Periodic acid-Schiff stain revealed mild mixed interstitial inflammation with lymphocytes, plasma cells, and neutrophils. (d) Trichrome stain with focal mild interstitial fibrosis and tubular atrophy. (e) Electron microscopy. Large subepithelial electron dense deposits (arrow) consistent with "humps".
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fig1
Preliminary biopsy report was consistent with postinfectious glomerulonephritis (Figure 1). A month later, creatinine had decreased to 1.9 mg/dL (168 mumol/L), and in a 3-month period, it had returned to baseline and proteinuria and hematuria had completely resolved (Figure 3 and Table 1).
(a) Light microscopy. Hematoxylin and Eosin stain with decreased endocapillary proliferation of neutrophils with some karyorrhectic debris and moderate crescents. (b) Jones stain with an early fibroepithelial crescent. (c) Trichrome stain with crescent and focal mild interstitial fibrosis and tubular atrophy. (d) Electron microscopy. Minimal residual subendothelial electron dense deposits but no evidence of large subepithelial electron dense deposits "humps".
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fig2
Second kidney biopsy one week later revealed minimal residual subendothelial electron dense deposits, but no evidence of large subepithelial electron dense deposits (Figure 2).
Creatinine and spot urine protein/creatinine ratio during clinical course.
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fig3
A month later, creatinine had decreased to 1.9 mg/dL (168 mumol/L), and in a 3-month period, it had returned to baseline and proteinuria and hematuria had completely resolved (Figure 3 and Table 1).