PMC9536094_01
Endoscopic appearance of MCC with gastric metastasis.
10.1177_11795476221112382-fig1.jpg
PMC9536094_01_10.1177_11795476221112382-fig1.jpg
fig1-11795476221112382
Gastroenterology was consulted and performed an upper endoscopy which revealed a malignant appearing 3-cm ulcerated gastric nodule with stigmata of recent bleeding (Figure 1).
Chromogranin stain, 600x magnification of gastric mucosal biopsy.
10.1177_11795476221112382-fig2.jpg
PMC9536094_01_10.1177_11795476221112382-fig2.jpg
fig2-11795476221112382
Tumor cells were positive for pancytokeratin, NSE, chromogranin, synaptophysin, and CK20 (classic perinuclear dot-like pattern) (Figures 2, 3, and 4).
Synaptophysin stain, 600x magnification of gastric mucosal biopsy.
10.1177_11795476221112382-fig3.jpg
PMC9536094_01_10.1177_11795476221112382-fig3.jpg
fig3-11795476221112382
Tumor cells were positive for pancytokeratin, NSE, chromogranin, synaptophysin, and CK20 (classic perinuclear dot-like pattern) (Figures 2, 3, and 4).
CK20 stain, 600x magnification, Gastric mucosal biopsy depicting tumor cell positivity in the characteristic paranuclear dot-like pattern.
10.1177_11795476221112382-fig4.jpg
PMC9536094_01_10.1177_11795476221112382-fig4.jpg
fig4-11795476221112382
Tumor cells were positive for pancytokeratin, NSE, chromogranin, synaptophysin, and CK20 (classic perinuclear dot-like pattern) (Figures 2, 3, and 4).
Hematoxylin and Eosin stain, 400x magnification of gastric wedge resection depicting gastric mucosa with tumor cells in the lamina propria.
10.1177_11795476221112382-fig5.jpg
PMC9536094_01_10.1177_11795476221112382-fig5.jpg
fig5-11795476221112382
These morphologic and immunohistochemical features along with the patient's history of MCC were consistent with a diagnosis of metastatic MCC (Figure 5).