PMC7577175_01
Clinical image shows an atrophic, indurated, and hypopigmented plaque on left submammary region. Histologically, extragenital lichen sclerosus is characterized by hyperkeratosis (+), epidermal atrophy with flattening of rete ridges (*), edema in the superficial dermis (#), and homogenized collagen in the dermis with subtotal loss of skin adnexal structures (**).
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F1
However, during the last months of the therapy, she presented with an itchy atrophic, indurated hypopigmented plaque on left submammary region (Figure 1). The clinical suspicion of extragenital lichen sclerosus was confirmed by histological evaluation of the lesion revealing hyperkeratosis, epidermal atrophy with flattening of rete ridges, edema in the superficial dermis, and homogenized collagen in the dermis with subtotal loss of skin adnexal structures (Figure 1).