PMC8101654_01
Mammography and photomicrographs of the aspiration smears. A - Well defined, sub-areolar, radio-opaque lesion within the breast; B - Cohesive clusters of tumor cells (Giemsa, 100X); C - Mildly pleomorphic polygonal tumor cells with centrally placed nuclei in a fluid background (Giemsa, 400X).
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On examination, the mass appeared non-tender, firm, mobile, and was located in the central quadrant (Figure 1A).
Photomicrography of the tumor. A - Microcystic and follicular arrangement of the tumor cells with eosinophilic extracellular secretion (H&E, 100X); B - Intracellular vacuolation and eosinophilic secretion (H&E, 200X); C - Magenta colored secretion for Periodic acid Schiff stain (H&E, 100X); D - No positivity for ER immunostain (200X).
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HER2/neu was done by immunostain and incomplete; faint membranous staining was noted in more than 10% of the tumor cells (Figures 2 D, 33B). Hence, the tumor was labeled as negative (score 1) and fluorescent in-situ hybridization (FISH) was not performed.