PMC3623451_01
Bronchial brushings in Thin Prep (a) Scanning view showing columnar cell clusters in mucoid background (Papanicolau stain x40) (b) Rare cluster of bronchial epithelial cells with terminal bars and cilia (Papanicolau stain x400) (c) Many clusters composed of disorganized columnar cells with abundant vacuolated cytoplasm and irregular nuclear contours (Papanicolau stain x400) (d) CDX2 nuclear positive stain (x400) (e) CK20 positive stain (x400) (f) CK7 negative stain (x200)
CJ-10-1-g001.jpg
PMC3623451_01_CJ-10-1-g001.jpg
F1
The lesional cells were positive for CK20 and CDX2 but negative for CK7 (performed on Thin Prep slides, Figure 1).
Concurrent bronchial biopsy specimen showing well differentiated mucin secreting adenocarcinoma with vacuolated cytoplasm and irregular nuclear outlines (a) H and E, x100 (b) CDX2 and (c) CK20 are positive (x400)
CJ-10-1-g002.jpg
PMC3623451_01_CJ-10-1-g002.jpg
F2
The concurrent biopsy and the previous resection specimens showed similar cytomorphologic features and immunohistochemical profiles [Figure 2].