PMC3764336_01
MRI brain scans of Patient SA. (A) Sagittal image demonstrating loss of volume of the left medial frontal and parietal cortex with a pathologically widened cingulate sulcus. (B) Coronal images showing loss of cortical volume particularly of the superior parietal lobe adjacent to a widened intraparietal sulcus, most prominently on the left, together with reduction in caudate head volume bilaterally. (C) Axial images demonstrating widened sulci over superior parietal and frontal regions, including the left central sulcus. White arrowhead = cingulate sulcus; yellow arrowhead = left intraparietal sulcus; red arrowhead = left central sulcus; green arrowhead = caudate head.
gr1.jpg
PMC3764336_01_gr1.jpg
fig1
Magnetic resonance imaging (MRI; Fig. 1) demonstrated cortical atrophy, slightly more prominent over parietal than frontal regions and in the left hemisphere compared to the right. Selected images in Fig. 1 demonstrate loss of volume of the left medial frontal and parietal cortex with a pathologically widened cingulate sulcus (white arrowhead); loss of cortical volume adjacent to a widened intraparietal sulcus particularly involving the superior parietal lobe, most prominently on the left (yellow arrowhead); widened sulci over superior parietal and frontal regions, including the left central sulcus (red arrowhead); and reduction in caudate head volume bilaterally (left side marked with green arrowhead).