PMC3228386_01
Family Pedigree. Arrows refer to index patients. Causes of death for A and B-natural causes. B had been diagnosed with a benign pituitary tumor. Cause of death for D and F (Sibling 2 and 1 respectively) - Glioblastoma Multiforme. Cause of death for E - Acute Myeloid Leukemia at the age of 60. Family member K was diagnosed with colorectal cancer in 2008 at the age of 45. All other members of family in pedigree are alive and healthy
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F1
Sibling 2 (Person D on pedigree diagram Figure 1) was an 81-year-old Caucasian male with a history significant for colorectal cancer, prostate cancer, and malignant melanoma.
Sibling 1. (a) MRI Brain Axial view T1 with contrast. Large mass located in left temporal lobe region as well as second mass in left occipital region. (b) MRI Brain sagittal T1 with contrast - note the ring enhancement of both lesions. (c) Areas of mitotic activity in tumor cells with increased cellularity consisting of gemistocytic astrocytes (H and E, x100). (d) Areas of tumor, tumor necrosis and endothelial/vascular proliferation; all necessary to make a diagnosis of glioblastoma (H and E, x10)
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F2
Another lesion was discovered in the left occipital lobe measuring 1.7 x 1.5 x 1.7 cm [Figure 2a and 2b]. Histological examination of fresh tissue revealed a malignant hypercellular astrocytoma with microvascularization, necrosis, abnormal mitoses, and bizarre nuclei [Figure 2c and 2d].
PMC3228386_02
Family Pedigree. Arrows refer to index patients. Causes of death for A and B-natural causes. B had been diagnosed with a benign pituitary tumor. Cause of death for D and F (Sibling 2 and 1 respectively) - Glioblastoma Multiforme. Cause of death for E - Acute Myeloid Leukemia at the age of 60. Family member K was diagnosed with colorectal cancer in 2008 at the age of 45. All other members of family in pedigree are alive and healthy
SNI-2-153-g001.jpg
PMC3228386_02_SNI-2-153-g001.jpg
F1
Sibling 2 (Person D on pedigree diagram Figure 1) was an 81-year-old Caucasian male with a history significant for colorectal cancer, prostate cancer, and malignant melanoma.
Sibling 2. (a) MRI Brain with contrast enhanced T1 axial peripherally enhanced lesion in right temporal lobe region extending to the dural surface. (b) MRI Brain T1 sagittal view of same lesion. (c) Cellular glial neoplasm with gemistocytic astrocytes (H and E, x100) (d) Cellular glial neoplasm with vascular proliferation and focal necrosis (H and E, x10)
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F3
Subsequent MRI studies showed a large peripherally enhanced lesion in the right temporal lobe extending from the dural to the ventricular surface [Figure 3a and 3b]. Histopathological evaluation and cytogenetic analysis on specimens were performed [Table 1, Figure 3c and 3d].