PMC6507100_01
Radiolucent and well-delimited lesion surrounding the third molar in the left side of the mandible.
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Panoramic radiography revealed a well-delimited radiolucent lesion circumscribing the tooth germ of the third molar (Figure 1).
Microscopically, the lesion was characterized by a loose connective tissue recovered by a columnar epithelium (a). Areas with different cell densities were noticed in the specimen (b, c). In some regions, upon the columnar cells, 3 layers of stratified squamous cells were detected exhibiting an outer enamel epithelium-like morphology (d). Scale bar: (a): 80 mum; (b-d): 20 mum.
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Histologic analysis revealed a fragment of loose connective tissue covered with the epithelium exhibiting predominantly a columnar morphology (Figure 2(a)). In the connective tissue, areas with a great number of cells showing a morphology ranging from fusiform to stellate morphology were noticed (Figure 2(b)). On the other hand, regions with low cell density and myxoid appearance were also observed in the connective tissue (Figure 2(c)). In some areas, the columnar cells were covered by a stratified squamous epithelium, which was interpreted as similar to the outer enamel epithelium of the enamel organ (Figure 2(d)).