PMC5896418_01
Section of the lymph node shows numerous atrophic germinal centers with marked vascular proliferation in the interfollicular area along with increased number of plasma cells (arrow); (a) x40, (b) x100, and (c) x200; focal vascular malformation is noted near the capsule (d) (x40); Immunostains CD31 and ERG highlight vascular proliferation (e) and (f) (x200), respectively; a large portion of the vascular endothelial cells and scattered cells in lymphoid follicles are positive for herpes virus type 8 (HHV8) by immunohistochemical staining (g) (x200); focal increased number of Epstein-Barr virus (EBV) positive cells are also noted by in situ hybridization for Epstein-Barr virus-encoded RNA (EBER) (h) (x400).
CRIHEP2018-9324872.001.jpg
PMC5896418_01_CRIHEP2018-9324872.001.jpg
fig1
Periaortic lymph node biopsy showed human herpes virus 8 (HHV8) associated Castleman's disease and marked vascular proliferation (Figure 1).