PMC8490074_01
Microscopic images of the renal biopsy (H&E). (a) The biopsy was composed of two cores of renal tissue (40x). (b) It showed diffuse endocapillary proliferative glomerulonephritis with epithelial crescents (arrow) (100x). (c) Some glomeruli showed neutrophil infiltration (arrow) (400x) and (d) necrotizing lesions (arrow) (400x).
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fig1
These crescents expanded beyond the limit of Bowman's capsule disrupting the glomerular outline (Figure 1).
Periodic acid-Schiff (a) and silver (b) stained sections showed disruptive crescents extending beyond the limit of Bowman's capsule (arrows) (400x). (c) Immunofluorescence of C3 showed coarse granular mesangial deposits (400x). Immunofluorescence was negative for IgG (d), IgA (e), IgM (f), and C1q (g).
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fig2
IgA, IgG, IgM, and C1q. It was concluded as ANCA-negative pauci-immune CGN with isolated C3 deposits (Figure 2).