PMC4694747_01
Representative features of endoscopic findings of colonic enteropathy-associated T-cell lymphoma. (A) Colonoscopy revealed hyperemic, thickened mucosa with central ulceration on the cecum and (B) flesh-like flat thickened lesions on the proximal descending colon. (C) There was a discrete ulcerative lesion with diffuse mucosal thickening and edematous mucosa on the ascending colon.
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Colonoscopy revealed about 3-cm-sized discrete ulcerative lesion with hyperemic edematous mucosa on the proximal ascending colon (Fig. 1C).
PMC4694747_02
Representative features of endoscopic findings of colonic enteropathy-associated T-cell lymphoma. (A) Colonoscopy revealed hyperemic, thickened mucosa with central ulceration on the cecum and (B) flesh-like flat thickened lesions on the proximal descending colon. (C) There was a discrete ulcerative lesion with diffuse mucosal thickening and edematous mucosa on the ascending colon.
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Colonoscopy revealed about 3-cm-sized discrete ulcerative lesion with hyperemic edematous mucosa on the proximal ascending colon (Fig. 1C).
Representative features of typical pathologic findings of colonic enteropathy-associated T-cell lymphoma. (A) The colon biopsy showed heavy intraepithelial lymphocytosis involving the surface epithelium (H&E stain, x200). Many CD8-positive (B), CD56-positive (C), and T-cell in-tracellular antigen 1-positive (D) intraepithelial lymphocytes were scattered (x200).
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Biopsy specimens from the lesion showed diffuse infiltration of small- to medium-sized atypical lymphoid cells with CD4-, CD8+, CD56+, and T-cell intracellular antigen 1 (TIA-1)+ immunophenotypes (Fig. 2).
Representative features of endoscopic findings of the small-bowel enteropathy-associated T-cell lymphoma. (A) Double-balloon-enteroscopy (DBE) showed diffuse fine granularity and edematous mucosa with circumferential shallow ulcerations on the ileum. (B) DBE revealed diffuse mucosal thickening and nodularity with multiple shallow semicircular ulcerations from the mid to distal jejunum. In another cases, shallow ulcerations encircled the diffusely swollen mucosa of the jejunum (C), and innumerable fine granular elevations (velvety or sand-like mucosa) were observed on the mid to distal jejunum (D).
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EGD through the gastrojejunostomy site revealed shallow ulcerations which encircled the diffusely swollen lumen of the afferent loop of the jejunum (Fig. 3C). Edematous mucosa with innumerable fine granular elevations, described as velvety or sand-like mucosa, caused obstruction of the, mid to distal jejunum (Fig. 3D).
PMC4694747_03
Representative features of endoscopic findings of the small-bowel enteropathy-associated T-cell lymphoma. (A) Double-balloon-enteroscopy (DBE) showed diffuse fine granularity and edematous mucosa with circumferential shallow ulcerations on the ileum. (B) DBE revealed diffuse mucosal thickening and nodularity with multiple shallow semicircular ulcerations from the mid to distal jejunum. In another cases, shallow ulcerations encircled the diffusely swollen mucosa of the jejunum (C), and innumerable fine granular elevations (velvety or sand-like mucosa) were observed on the mid to distal jejunum (D).
gnl-10-147f3.jpg
PMC4694747_04_gnl-10-147f3.jpg
f3-gnl-10-147
EGD through the gastrojejunostomy site revealed shallow ulcerations which encircled the diffusely swollen lumen of the afferent loop of the jejunum (Fig. 3C). Edematous mucosa with innumerable fine granular elevations, described as velvety or sand-like mucosa, caused obstruction of the, mid to distal jejunum (Fig. 3D).
PMC4694747_04
Representative features of endoscopic findings of the small-bowel enteropathy-associated T-cell lymphoma. (A) Double-balloon-enteroscopy (DBE) showed diffuse fine granularity and edematous mucosa with circumferential shallow ulcerations on the ileum. (B) DBE revealed diffuse mucosal thickening and nodularity with multiple shallow semicircular ulcerations from the mid to distal jejunum. In another cases, shallow ulcerations encircled the diffusely swollen mucosa of the jejunum (C), and innumerable fine granular elevations (velvety or sand-like mucosa) were observed on the mid to distal jejunum (D).
gnl-10-147f3.jpg
PMC4694747_04_gnl-10-147f3.jpg
f3-gnl-10-147
EGD through the gastrojejunostomy site revealed shallow ulcerations which encircled the diffusely swollen lumen of the afferent loop of the jejunum (Fig. 3C). Edematous mucosa with innumerable fine granular elevations, described as velvety or sand-like mucosa, caused obstruction of the, mid to distal jejunum (Fig. 3D).
Representative features of typical pathologic findings of small-bowel enteropathy-associated T-cell lymphoma. (A) The small intestine biopsy showed heavy intraepithelial lymphocytosis involving the surface epithelium (H&E stain, x200). Many CD8-positive (B), CD56-positive (C), and T-cell intracellular antigen 1-positive (D) intraepithelial lymphocytes were scattered (x200).
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TIA-1 positivity (Fig. 4). Tissue DNA analysis demonstrated monoclonal T-cell receptor gamma rearrangement.