PMC9934963_01
Genogram.
can-16-1487fig1.jpg
PMC9934963_01_can-16-1487fig1.jpg
figure1
Figure 1 describes his genogram.
Loss of the wild-type alternate allele (LOH) of TP53 and XAF1 germline variants.
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PMC9934963_01_can-16-1487fig2.jpg
figure2
TP53 (c.1010G>A, p.[Arg337His]) and in XAF1 (c.400G>T, p.[Glu134Ter]). Tumour DNA extracted from a paraffin-embedded biopsy of a pNET liver metastasis showed loss of the wild-type alternate allele (LOH) of both germline variants (Figure 2), with allele frequency of 92% for TP53 and allele frequency of 91% for XAF1.