PMC4772458_01
Malignant PT of the breast showing a leaf-like pattern with increased stromal cellularity and atypia (hematoxylin and eosin stain, original magnification x 100)
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Fig1
Histological examination showed a biphasic proliferation characterized by a double layered epithelial component arranged in clefts surrounded by an hpercellular fibrosarcomatous component organized in leaf-like structures Fig. 1.
Axial computed tomography image showing a moth-eaten appearance of the femoral head
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Fig2
Computed tomography and FDG-PET Scan revealed a moth-eaten appearance Fig. 2 and pathological FDG uptake of the left femoral head without other suspect lesions.
PMC4772458_02
Malignant PT of the breast showing a periductal stromal growth with malignant features (hematoxylin and eosin stain, original magnification x 100)
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Fig5
The patient's past medical history was significant for previous bilateral mastectomy for malignant PT one and two year ago Fig. 5.
Axial computed tomography showing a solid aggressive osteolytic mass of the left iliac bone with extensive soft tissue invasion
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Fig6
Computed tomography and magnetic resonance imaging revealed a solid aggressive osteolytic mass of the left iliac bone with extensive soft tissue invasion measuring 13 x 11 cm Fig. 6.
Proliferation of densely packed spindle cells (hematoxylin and eosin stain, original magnification x 100)
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Fig7
Biopsy of the tumor was performed and showed a sarcomatous proliferation similar to that described for the first case Figs. 7 and 8 with the same immunohistochemical profile.
Tumor cells showing severe nuclear atypia with mitoses (hematoxylin and eosin stain, original magnification x 400)
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Fig8
Biopsy of the tumor was performed and showed a sarcomatous proliferation similar to that described for the first case Figs. 7 and 8 with the same immunohistochemical profile.