PMC10176193_01
Immunohistochemistry of tumour biopsy specimen (x400 magnification), showing cytokeratin negative (a), LCA/CD45 positive (b), CD3 negative (c), CD20 positive (d), Ki67 expression +-95% (e), suggesting CD20 (+), highly proliferative DLBCL.
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F1
CD20 (+), highly proliferative DLBCL (Fig. 1a-c). Contrast CT scan showed a mass on the right maxillary sinus, destroying the posteromedial wall of the maxillary sinus, extending to the nasal cavity, ethmoid sinus, and masticator space, with metastasis to right cervical lymph nodes (Fig. 2a-c).
Pre-treatment head and neck CT scan with contrast, showing mass on right maxillary sinus destroying the posteromedial wall of maxillary sinus (a), extending to right parapharyngeal space (b), with metastasis to right cervical lymph nodes (c).
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F2
CD20 (+), highly proliferative DLBCL (Fig. 1a-c). Contrast CT scan showed a mass on the right maxillary sinus, destroying the posteromedial wall of the maxillary sinus, extending to the nasal cavity, ethmoid sinus, and masticator space, with metastasis to right cervical lymph nodes (Fig. 2a-c).
Post-treatment head and neck CT scan with contrast, showing residual mucosal thickening of right maxillary sinus (a), clear right parapharyngeal space (b), absence of right cervical lymphadenopathy (c), suggesting complete response.
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F3
A repeat CT scan was performed 1 month after the completion of chemotherapy, showing a complete response (Fig. 3a-e).