PMC6728670_01
Conditioning Regimen: Myeloablative FA5-CYBU protocol.
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An intensified conditioning of fludarabine (30mg/m2 qd for 5 days), busulfan (9.6 mg/kg separated into 3 days), cytosine arabinoside(2.0/m2 qd for 5 days), cyclophosphamide (3.6 g/m2 separated into 2 days), and rabbit antithymocyte globulin (ATG-Fresenius; 10 mg/kg) was selected to treat the patient (Fig 1).
Flowchart of sequencing system.
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The 1000 Genomes Project and ESP6500 database were used to filter no pathogenic mutation (Fig 2).