PMC6109551_01
CT scan showing (a) 15 cm splenomegaly after CLL diagnosis in 2006. (b) CT scan in 2013 showing increased massive splenomegaly (28 cm) with splenic infarct and hepatomegaly, after PMF diagnosis. (c) Bone marrow biopsy showing hypercellular bone marrow with fibrosis, consistent with the diagnosis of myelofibrosis.
CRIHEM2018-7426739.001.jpg
PMC6109551_01_CRIHEM2018-7426739.001.jpg
fig1
Bone marrow biopsy revealed a hypercellular bone marrow with increased reticulin stain and fibrosis (Figure 1). Imaging studies showed massive splenomegaly (Figure 1, about 28 cm on CT scan).
Karyotype showing trisomy 9, t (1; 6).
CRIHEM2018-7426739.002.jpg
PMC6109551_01_CRIHEM2018-7426739.002.jpg
fig2
A karyotype from the bone marrow showed chromosomal abnormalities of trisomy 9 (+9) and t (1; 6) (Figure 2).