PMC3138735_01
Proportion of positive samples (positivity rate) by age.. Points are located at the mean of the ages in the age groups; Germany 2009/2010.
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It first increased up to 10 years of age and then declined thereafter (Fig. 2).
Vaccinated cases by time between vaccination and Illness.. Frequency of reported and vaccinated laboratory-confirmed cases of pandemic influenza H1N1(2009) by interval between vaccination and illness onset; weeks of illness onset 44-53/2009; Germany.
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The number of vaccinated cases by interval between vaccination date and illness onset started with a peak on the first day after vaccination and decreased then rapidly to very low numbers by day 10-14 (Fig. 3).
Case-series method.. Frequency of total number of cases with known age and onset of illness (grey, left y-axis), of vaccinated cases by week of vaccination (dashed grey line; right y-axis), vaccinated cases by week of illness onset (unprotected period; dashed-dotted line; right y-axis), vaccinated cases by week of illness onset (protected period; black line; right y-axis) and vaccinated cases by week of illness onset that would be expected if the vaccine had no effect (protected period; dashed black line; right y-axis), Germany; week 44-53, 2009.
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Figure 4 shows the total number of cases by week of illness onset as well as the number of vaccinated cases by week of vaccination. The expected number of vaccinated cases during their protected period (assuming that VE is 0%) differs markedly from the curve with the actual number of vaccinated cases during the protected period (Fig. 4).
Vaccine effectiveness by weekly cohort.. Vaccine effectiveness of pandemic AS03-adjuvanted vaccine, by weekly vaccinated cohort; case-series method; force of infection is represented by all reported cases with available information on age, illness onset and vaccination status; for methods: see text; up = unprotected period, pp = protected period, pv = post vaccination.
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The VE estimates for the different weekly cohorts is relatively stable within the two age segments despite the low numbers of vaccinated cases (Tab. 3; Fig. 5).