PMC9534171_01
Dermatologic features of monkeypox in a 24-year-old Taiwanese man, showing skin lesions in different stages (asynchronous): Pustular and vesicular lesions over his neck (A), chest (B), arms (C), anal region (D), buttock (E), thigh (F), foot (G), genitals (H, I), and resolving with scabs over his buttock and thigh (J) and foot (K) on day 9 after disease onset.
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Hospital, Kaohsiung, Taiwan, with scattered vesicular and pustular skin lesions over his face, limbs, trunk, genital, perianal areas; tender, swollen, inguinal lymph nodes bilaterally; fever, sore throat, and myalgia for 2 days (Fig. 1 A-K). Examination revealed scattered pustules and vesicles over his face, limbs, trunk, genital, and perianal areas (Fig. 1 A-K).
Direct whole genome sequencing on the vesicular fluid sample by Oxford Nanopore MinION apparatus obtained 197,315 base pairs sequence. The results indicate that viral sequence shares high similarity with the "West African" monkeypox virus clade, including the European (Germany) and American lineages, rather than the "Central African" or Congo clade. The Taiwan monkeypox strain (MPXV/human/Taiwan/110-231642/2022) was submitted to GISAID (accession no. ON918656.1).
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The result indicates that the viral sequence shares higher similarity with the "West African" MPXV clade, including the European (Germany) and America lineages, rather than the "Central Africa" or Congo clade (Fig. 2 ). The accession numbers of Taiwan MPXV and other reference strains are listed in Fig. 2. 