PMC5070041_01
Large mass in the right lobe of the thyroid displacing the trachea medially, common carotid artery posteriorly, and sternocleidomastoid muscle laterally
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F1
The lesion had heterogeneous contrast enhancement with lobulated contour, and internal macrocalcifications with necrotic areas were obvious [Figure 1].
Hypercellular smear with prominent single cells, insular pattern, and transgressing vessels (Diff-Quik, x40)
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F2
The FNA was hypercellular not only as single cells but also insular and trabecular arrangements were noticed [Figures 2 and 3].
Cells have delicate eosinophilic cytoplasm (Pap, x400)
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F3
The FNA was hypercellular not only as single cells but also insular and trabecular arrangements were noticed [Figures 2 and 3].
Cells have a high nuclear/cytoplasmic ratio, nuclei are round, slightly hyperchromatic and relatively uniform with macronucleoli (Pap, x400)
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F4
Nuclei were round, slightly hyperchromatic, and macronucleoli were prominent [Figure 4].
Cell block (H and E, x40)
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F5
Immunohistochemical analyses were performed on the cell-block [Figure 5].
Diffuse nuclear TTF-1 positivity (x40)
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F6
PAX-8 revealed diffuse nuclear positivity, whereas p53 was positive in 9.2% of cell nuclei [Figures 6 and 7]. Pan-CK showed extensive and thyroglobulin (TG) weak focal cytoplasmic staining.
Nuclear p53 positivity (x40)
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F7
PAX-8 revealed diffuse nuclear positivity, whereas p53 was positive in 9.2% of cell nuclei [Figures 6 and 7]. Pan-CK showed extensive and thyroglobulin (TG) weak focal cytoplasmic staining.