PMC4531605_01
(A) Aggregation of monomorphous population of large lymphoid tumor cells (H&E, x200). (B) Immumohistochemical staining shows a positive reaction for CD20, which indicates a lymphoma of B-cell origin (H&E, x400).
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Histological examination of the biopsy taken transurethrally from two parts of the bladder mucosa and urethra showed malignant lymphoma (Figure 1A). Immunohistochemical study showed positive reaction for the monoclonal antibody marking B-lymphocytes (Figure 1B).
Abdomino-pelvic CT scan demonstrates left-side hydronephrosis and hydroureter with left proximal ureter infiltration (A) and left lateral wall of bladder thickening with perivesical fat infiltration (B). CT scan after two cycles of CHOP chemotherapy shows the nearly complete regression of the previous lesions (C, D).
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Abdomino-pelvic CT scan demonstrated left side hydronephrois and hydroureter with left proximal ureter infiltration and thickening of the left lateral wall of the bladder with perivesical fat infiltration without lymph node enlargement (Figure 2A, 2B). The lesions of the bladder and left urinary tract were nearly completely regressed after two cycles of systemic CHOP chemotherapy with simultaneous restoration of urinary function (Figure 2C, 2D).
Bone marrow biopsy shows diffuse infiltration of lymphoid cells (H&E, x400).
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Bone marrow aspiration and biopsy revealed normocellular marrow with diffuse infiltration of lymphoid cells (Figure 3).