PMC3235906_01
Antibody-mediated rejection characterized by endothelial cell swelling and numerous macrophages filling vascular spaces.
JTRAN2011-351950.001.jpg
PMC3235906_01_JTRAN2011-351950.001.jpg
fig1
An autopsy was performed, and although the initial gross evaluation failed to show the cause of her graft failure, histologic and pathologic myocardial sections eventually revealed severe but patchy cellular and antibody-mediated rejection. (Figures 1, 2(a), 2(b), and 3 show the pathologic findings of antibody-mediated rejection in the case described here.)
(a) Antibody-mediated rejection, high power. Longitudinal section of capillary with mild endothelial cell swelling and macrophages accumulating in lumen. (b) Immunoperoxidase staining with CD68 highlights the macrophages.
JTRAN2011-351950.002.jpg
PMC3235906_01_JTRAN2011-351950.002.jpg
fig2
An autopsy was performed, and although the initial gross evaluation failed to show the cause of her graft failure, histologic and pathologic myocardial sections eventually revealed severe but patchy cellular and antibody-mediated rejection. (Figures 1, 2(a), 2(b), and 3 show the pathologic findings of antibody-mediated rejection in the case described here.)