PMC3896681_01
Histopathologic examination of formalin fixed paraffin embedded (FFPE) biopsied tissue from the presumed primary tumor site. (A) Low power (100x). Cellular tumor composed of spindled cells. (B) High power (400x). Short atypical spindle cells with few mitotic figures. Immunohistochemical studies reveal the tumor to be reactive for (C) S-100 protein and (D) CD34.
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F1
The diagnosis of a malignant solitary fibrous tumor was also entertained, but the features were not typical for such a diagnosis (Figure 1 A,B upper left and right panels with 100x and 400x magnification, respectively). Immunohistochemical stains for S-100 and CD34 were positive (Figure 1 C,D lower left and right panels, respectively).
Imaging studies pre and post- treatment. A: Pre-treatment CT scan of the Chest shows left chest wall tumor invading the ribs and left sided pleural effusion. B. Post-treatment CT scan of the Chest shows a decrease in size of the tumor and decrease in pleural effusion.
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F2
After of two cycles of therapy, the patient had a 25% reduction in greatest unidimensional tumor measurment per RECIST 1.1 (Figure 2 A,B), which is stable disease (SD), and also just below the criteria for a partial response (PR).