PMC4313754_01
Structurally dissimilar base chemical structures of clopidogrel and ticagrelor. Note the base chemical structure similarity of clopidogrel and ticlopidine, and to a lesser extent prasugrel.
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F1
Given his reaction to three antiplatelet agents, and after reviewing the molecular structure of all four drugs (Fig. 1), as well as available literature on clopidogrel sensitisation and its cross-reactivity towards ticlopidine and prasugrel, there was significant concern about the risk of similar but more severe and rapid onset hypersensitivity reaction.