PMC7370553_01
(a) Painful ulcer with undermined borders and purulent discharge diagnosed as pyoderma gangrenosum on the left lower leg before secukinumab; (b) improvement after 1 month; (c) 2 months; and (d) 3 months of secukinumab, started at 300 mg subcutaneous weekly for 5 weeks, followed by monthly maintenance dosing.
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On presentation to dermatology, there was a tender, 14 cm x 9 cm granulating ulcer on the left lower medial leg with irregular, undermined borders (see Figure 1(a)). The patient had significant improvement after 3 months of treatment; she had no pain and the ulcerated skin had healed completely (see Figure 1(b)-(d)).