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The pictures of patients' hands and feet before and after the treatment of dupilumab. From case 1 to case 5.
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Hyperkeratosis and erythema gradually recovered during the therapy (Figure 1). 
Dynamic changes of various parameters during the dupilumab therapy. The sequence of five charts was as follows: (A) Eosinophils, (B) IgE, (C) HECSI, (D) PESCI and (E) PP-NRS.
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The pruritus of all the patients was also markedly alleviated, which obviously improved the life quality of patients (Figure 2).