PMC2636039_01
Clinical appearance, A and B - at presentation, C - immediately
after incision biopsy and D - 2.5 months after starting therapy
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F1
Lid edema, prominent vessels over the lids and lagophthalmos were more pronounced in the left than the right eye [Fig. 1]. Proptosis completely disappeared, the exposure keratitis of the left eye healed and disc edema totally subsided 2.5 months after starting therapy [Fig. 1].
Computerized tomography showing erosion of medial orbital
walls into nose and lateral wall of the nose bordering infratemporal
fossa on both sides
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F2
Computerized tomography [Fig. 2] showed diffuse infiltration of the orbit and erosion of medial wall of the orbit bordering the nose and lateral wall of the nose bordering the infratemporal fossa on both sides.
H and E staining A (10X), B (40X) showing solid sheets of
predominantly undifferentiated cells along with a few interspersed
elongated and fusiform cells with central nucleus and eosinophilic
cytoplasm. The undifferentiated cells are round to elongated with large
pleomorphic nucleus and prominent single to multiple nucleoli with
numerous atypical mitosis. Few vacuolated cells are also seen. Positive
Leukocyte Common Antigen (C) and Vimentin stains (D)
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F3
Histopathological sections [Fig. 3] study showed solid sheets of predominantly undifferentiated cells along with a few interspersed elongated and fusiform cells with central nucleus and eosinophilic cytoplasm. It was negative for all markers except Vimentin and Leukocyte Common Antigen [Fig. 3].