PMC7682778_01
Flow cytometric (FCM) immunophenotyping of the bone marrow. FCM indicated that the abnormal B lymphocyte population mainly expressed CD19, CD45, HLA-DR, CD22, CD20, CD103, CD99 and negative for CD25, CD117, CD56, and FMC7.
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Flow immunophenotyping can detect abnormal B lymphocyte population, the phenotype was similar to the initial course and mainly expressed CD19++, CD45++, HLA-DR++, CD22++, CD20++, CD103++, CD99+, CD25-, CD117-, CD56-, and FMC7- (Figure 1), which indicated the relapse of the disease.
The change of skin rash induced by cladribine in HCL, before (A-C) and after (D-F) rescue. The diffuse, exfoliated, and itchy erythema (throughout the chest, back and limbs) gradually faded after a combination treatment with corticosteroids, immunoglobulin, ebastine, and sodium thiosulfate.
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Moreover, the rash on the chest and abdomen, back, and both lower limbs (Figure 2A-C) darkened and was intensively distributed. Then, the patient was discharged (Figure 2D-F).