PMC7553885_01
Initial clinical aspect. Erythematous lesion with whitish areas, irregular and granulomatous surfaces involving the soft palate, pharyngeal arches and pharynx.
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Intraorally, total denture with satisfactory hygiene; presence of a non-bleeding erythro-leucoplastic lesion with irregular surface and diffuse contours that affected the soft palate and oropharynx (Fig. 1).
CT Scan. (A and B) Images suggest muco-periosteal reaction in palatal region not compatible with neoplasia. Free airways.
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Histopathological Findings. (A) Mucosa coated by hyperparqueredized squamous epithelium exhibiting exocytosis and pseudoepitheliomatous hyperplasia. The lamina propria consists of dense connective tissue with intense chronic inflammatory infiltrate and the presence of multinucleated giant cells of the Langerhans type. (B) PAS staining and Grocott demonstrated yeasts with birefringent circular structural fields compatible with Paracoccidioides brasiliensis (arrows).
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Material was collected for incisional biopsy demonstrating non-specific chronic inflammatory tissue sections with immunohistochemical markings for Paracoccidiodesbrasiliensis (Fig. 3).