PMC3797528_01
Magnetic resonance (MR) imagines of patient with 4H syndrome. (A) MR T1-weighted axial scan demonstrates iso- or hyperintensity of the cerebral white matter. (B) MR T2-weighted axial scan demonstrates irregular hyperintensity of the cerebral white matter with hypointensity of the optic radiations (white arrow), lateral thalamus (thick black arrow), and dentate nucleus (thin black arrow).
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F1
A follow-up MRI showed no significant changes (Fig. 1). The clinical and neuroimaging findings (Fig. 1) remained globally stable except for the development of vertical gaze palsy, horizontal restrictive gaze and absence of smooth pursuit.