PMC9618642_01
PMC9618642_02
Brain imaging of subjects with PLPHP deficiency. MRI of subjects 2 (A-D) and 3 (E,F) at 4.5 and 2.5 years. (A,E) Sagittal T1 demonstrates thin corpus callosum. (B,F) Axial views show a patchy bilateral increase in T2 and (C,D,G,H) FLAIR signal in the deep white matter around the ventricles at bilateral frontal and bilateral peritrigonal regions. Both subjects have cerebral atrophy, most noted in subject 2, with a prominence of CSF spaces, particularly over frontal and sylvian regions bilaterally.
fneur-13-913652-g0001.jpg
PMC9618642_03_fneur-13-913652-g0001.jpg
F1
The CSF spaces and ventricles were enlarged, suggesting poor cerebral growth (Figures 1E-H).
PMC9618642_03
Brain imaging of subjects with PLPHP deficiency. MRI of subjects 2 (A-D) and 3 (E,F) at 4.5 and 2.5 years. (A,E) Sagittal T1 demonstrates thin corpus callosum. (B,F) Axial views show a patchy bilateral increase in T2 and (C,D,G,H) FLAIR signal in the deep white matter around the ventricles at bilateral frontal and bilateral peritrigonal regions. Both subjects have cerebral atrophy, most noted in subject 2, with a prominence of CSF spaces, particularly over frontal and sylvian regions bilaterally.
fneur-13-913652-g0001.jpg
PMC9618642_03_fneur-13-913652-g0001.jpg
F1
The CSF spaces and ventricles were enlarged, suggesting poor cerebral growth (Figures 1E-H).