PMC5721486_01
(a) The smear shows many ball-like clusters in a necrotic background (Papanicolaou, x20). (b) Tumor cells have large nuclei with prominent nucleoli, and moderate amount of cytoplasm. (Papanicolaou, x400).
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F1
The cytologic features showed many ball-like tumor cell clusters in a necrotic background [Figure 1a]. These large neoplastic cells showed moderate amount of cytoplasm, prominent nucleoli, and nuclear overlapping [Figure 1b].
(a) The cervical biopsy specimen shows well-defined nests, tubules, rosettes and peripheral palisading pattern of tumor cells. (b) The tumor cells have abundant cytoplasm, large nuclei, prominent nucleoli, and focal nuclear molding (H and E, x400). (c) The tumor cells show an immunoreactivity for synaptophysin (x100). (d) The tumor cells show an immunoreactivity for CD56 (x100).
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F2
The nuclei of neoplastic cells were large with prominent nucleoli and focal nuclear molding [Figure 2a and b]. Immunohistochemical stains exhibited positive reactivity for synaptophysin, chromogranin, and CD56 [Figure 2c and d].
(a) Blurred or abortive rosettes is observed in some cluster (Papanicolaou, x400). (b) In immunocytochemistry, the tumor cells show a positivity for synaptophysin (x200).
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F3
Tumor cell clusters showed blurred or abortive rosettes [Figure 3a]. ThinPrep Pap smear vial. The synaptophysin immunostain demonstrated positive reactivity in tumor cells [Figure 3b].