PMC7768563_01
Hailey-Hailey disease with bilateral eroded macerated erythematous plaques in inguinal
regions.. This picture was taken during an exacerbation in the last year, and the patient's rash
was considerably worse at first consultation (no pictures available).
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Bilateral macerated erythematous plaques with erosions were noted in the inguinal regions extending to lateral labia majora (Figure 1).
A hematoxylin phloxine saffron-stained section at 10x magnification shows multi-layered
intraepidermal acantholysis with few dyskeratosis and parakeratosis, and perivascular
lymphocytic infiltrates in the superficial dermis.
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Skin biopsy revealed acantholysis at multiple levels in the epidermis, resembling a "dilapidated brick wall" with few dyskeratosis and parakeratosis (Figure 2).
Timeline of management and response to treatments.. HHD: Hailey-Hailey disease.
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A timeline of management is presented in Figure 3.