PMC4861795_01
Axial CT neck (a and b), sagittal CT neck (c and d), and coronal CT neck (e), with contrast, show the anteriorly sessile soft tissue mass arising from the laryngeal surface of epiglottis, with relatively stable position. The epiglottis has no submucosal extension.
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fig1
Direct visualization of the mass through mouth (a) and flexible fiberoptic laryngoscopy shows the mass extending to oropharynx (b), but the glottis was not involved and was visualized when passing the scope around the mass (c).
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fig2
Just beyond the mass, the hypopharynx and laryngeal inlet were normal in appearance (see Figure 2).
Permanent sections showing histology of B-cell lymphoma; low power (a) and high power (b) show the typical histological structure. Further immunostainings of the mass for typical lymphoma markers, including CD3 (c), CD10 (d), CD20 (e), BCL2 (f), BCL6 (g), Ki67 (h), and MUM1 (i).
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fig3
The biopsy revealed an unusual B-cell lymphoma subtype (see Figure 3), based on immunostaining and in situ hybridization (Table 1).
Laryngoscopy was performed three months posttreatment. There was no evidence of residual tumor.
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fig4
She was seen again four months later with normal voice and remained disease free on examination (Figure 4).