PMC6362841_01
T2-weighted magnetic resonance image of patient's brain demonstrates T2 hyper-intense signal with associated diffusion restriction in the cortex, predominantly in the parietal and temporal lobes, and predominantly on the left. Note associated gyral thickening.
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F1
A repeat brain MRI showed bilateral cortical ribboning not reported on previous imaging (Figure 1).
MRI of patient's brain over a year prior to presentation at our institute, reported as notable only for evidence of chronic small vessel disease. Diffusion weighted sequence imaging (left) indicates cortical ribboning retrospectively though T2-weighted image (right) does not yet reflect these findings and there is no gyral thickening.
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F2
While the documented imaging reports did not report CJD-associated MRI findings, subsequent review of the images indicated that our patient had evidence of cortical ribboning on early imaging done at initial evaluation (Figure 2).