PMC4711036_01
Panel A, B and C demonstrate spirals and handwriting of patient 1 in January 2013, February 2013, and May 2013, respectively. She was on no medication in January 2013, levetiracetam 2,000 mg/day in February 2013, and levetiracetam 2,000 mg/day and primidone 100 mg/day in May 2013. Panels A1, B1 and C1 are spirals from the left hand, and panels A2, B2 and C2, are from the right. Panels B3 and C3 are handwriting from the right hand. There is improvement of her hand spirals and handwriting over time.
40734_2014_13_Fig1_HTML.jpg
PMC4711036_01_40734_2014_13_Fig1_HTML.jpg
Fig1
This tremor was also visible on Archimedes spiral (Figure 1A). She was started on levetiracetam with a slow titration to 2,000 mg/day, with marked improvement of both her myoclonus, the ET-like movements of her hands (Figure 1B and C), and symptoms of OT (Additional file 2: Video 2).
PMC4711036_02