PMC8350112_01
(A) Glomeruli show a lobular flocculus with a global and diffuse endocapillary proliferation associated with mesangial hypercellularity. Crescents with fibrinoid necrosis were present (arrow) (Trichrome stain: original magnification: 400x). (B) By immunofluorescence, IgG deposits were diffusely observed and organized in a starry sky pattern (FITC: original magnification: 400x). (C) Numerous subepithelial (humps) and mesangial dense deposits were observed by electronic microscopy. Arrow shows so called humps. (D,E) By immunofluorescence, C3 (D) and C5-9 (E) deposits were diffusely observed (FITC: original magnification: 400x).
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F1
Mesangial and endocapillary hypercellularity were present, with crescent formation in 2 out of 21 glomeruli (Figure 1A). Immunofluorescence revealed abundant IgG, C3 and C5-9 deposits arranged in starry sky pattern (Figures 1B,D,E). Ultrastructural analysis displayed subepithelial electron-dense "humps" (Figure 1C).
PMC8350112_02