PMC6079566_01
Breast MRI. Ill-defined deep retroareolar spiculate mass-like lesion extending over 3 x 1.5 cm revealing early enhancement peak with associated architectural distortion.
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Findings were suggestive of BIRADS type IV lesion (Figure 2).
(a and b) Low magnification histopathological examination of the breast tumor demonstrating nests of neoplastic epithelial cells in a background of dense lymphocytic infiltrate. (c and d) Higher magnification showing the tumor cells with abundant pale cytoplasm, large vesicular nuclei, and prominent nucleolus (hematoxylin and eosin stain).
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An excisional biopsy was performed and revealed breast tissue with extensive lymphocytic infiltrate intermixed with neoplastic epithelial cells (Figure 3).
The lymphocytes show positive immunohistochemical staining for CD3 (a), CD20 (b), and the tumor cell-positive immunohistochemical staining for cytokeratin AE1/AE3 (c).
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Immunohistochemistry results were positive for CK AE1/E3 antibody in the neoplastic epithelial cells with no expression of estrogen or progesterone receptors, and HER2/neu was not overexpressed (Figure 4(c)). The lymphocytes in the background stained positive for both CD3 and CD20 (Figures 4(a) and 4(b)).