PMC4929492_01
Axial (left) and sagittal (middle) T1 weighted MRI with gadolinium, and sagittal CT scan (right) of unsecured AV fistula.
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A pre-surgical computed tomography angiogram and brain magnetic resonance imaging (Figure 1) demonstrated a complex brain AV malformation with preserved pallidal anatomy.
Sample LFP spectrograms in GPI (action) (A) and GPE (B). Corresponding GPI (C) and GPE (D) power spectral densities are included. Brackets (A-D): Delta, delta (0-3Hz); theta, theta (4-7 Hz); alpha, alpha (8-12Hz); Lbeta, low beta (13-20Hz); Hbeta, high beta (21-29Hz); gamma, gamma (30-200Hz). Mean PSD values (+- SEM) for each spectral band for GPI (action) (E), GPI (rest) (F) and GPE (G) are shown.
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LFP recordings revealed highest powers in delta and theta followed by a decrease in power with each subsequent frequency after (alpha, beta, and gamma) with action (Figure 2). Beta frequencies had significantly more power than gamma in the Gpi (p = 0.0067) (Figure 2).
Paired t-test of GPI firing frequency at rest vs. action (A) and GPI bursting index at rest vs. action (B).
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Microelectrode recording (MER) were obtained in the Gpi and Gpe to study neuronal firing rates and bursting indices (BIs) (Figure 3). Furthermore, no changes were found in the Gpi BI rest (4.55+-0.93) action (5.58+-0.84) (p = 0.28, Figure 3).