PMC3886104_01
Intraoral view showing buccal (A) and lingual (B) cortical expansion and
overlying mucosal ulceration.
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fig1
Two ulcers were seen with respect to the swelling, one on the anterior lingual aspect measuring about 12 x 8 mm and second one measuring about 5 x 4 mm (Figure 1A, B).
Computed tomography image showing mandibular cortical plate expansion and
erosion of the bony plates.
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fig2
Computed tomographic image of the mandible showed an ill-defined radiolucent mass with respect to the left ramus/body area of size about 2 x 3 cm (Figure 2).
The surgically excised mandibular specimen showing the extent of the
lesion.
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fig3
Patient underwent hemi-mandibulectomy along with excision of the tumour mass under general anaesthesia, following which he was suggested radiation therapy (Figure 3).
Haematoxylin and eosin stained section of ameloblastic carcinoma showing
cellular atypia (original magnification x400).
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fig4
Necrosis, vascular and neural invasion were not observed (Figure 4).
Increased expression of alpha smooth muscle actin in ameloblastic carcinoma
(original magnification x100).
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fig5
AC showed strong immunoreactivity to alpha-SMA in the stroma surrounding the tumour islands (Figure 5). Additional finding was that few cells within the tumour island also exhibited faint positivity towards alpha-SMA (Figure 6A, B).
Expression of alpha smooth muscle actin (indicated by arrows) in the
epithelial islands of ameloblastic carcinoma: A = original magnification
x200; B = original magnification x400.
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fig6
AC showed strong immunoreactivity to alpha-SMA in the stroma surrounding the tumour islands (Figure 5). Additional finding was that few cells within the tumour island also exhibited faint positivity towards alpha-SMA (Figure 6A, B).
Expression of alpha smooth muscle actin in the stroma of follicular
ameloblastoma (original magnification x200).
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fig7
Positive cells in the wall of endothelial vessels were taken as internal positive control (Figure 7).