PMC7499309_01
Bone marrow aspirate. Numerous blast cells (arrow) with scant, basophilic cytoplasm containing occasional vacuoles are shown (May-Grunwald-Giemsa: (a) 200x and (b) 1000x).
CRIPA2020-5606391.001.jpg
PMC7499309_01_CRIPA2020-5606391.001.jpg
fig1
Bone marrow smears were highly cellular, with numerous atypical blasts with a scant, basophilic cytoplasm, occasional small vacuoles, and prominent mitotic figures (Figures 1(a) and 1(b)).
Photographs of bone marrow biopsy with primary Burkitt lymphoma. Low magnification showed a (a) hypercellular bone marrow with (b) monotonous infiltration of medium-sized lymphocytes that displayed (c) many mitotic (arrowhead) and apoptotic figures (arrow). Immunohistochemical analysis of lymphoma cells showed positivity for (d) CD20, (e) CD10, (f) Bcl-6, and (g) c-myc, while (h) Bcl-2 was negative. (i) Ki67 proliferative rate of tumor cells was nearly 100%.
CRIPA2020-5606391.002.jpg
PMC7499309_01_CRIPA2020-5606391.002.jpg
fig2
A starry sky pattern with numerous tangible body macrophages was present (Figures 2(a)-2(c)). Ki67 was positive in nearly 100% of tumor cells (Figures 2(d)-2(i)).