PMC9253620_01
Timeline of the patient's clinical manifestations and treatment.
IDR-15-3417-g0001.jpg
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TMP-SMX (120 mg/kg dose Q6H) combined with CAS (14.4 mg, QD) as well as MEM (100 mg Q8H) was continued for 11 days (Figure 1).
PMC9253620_02
Imaging data of lungs. (A) on the 1st day of admission, CR showed exudation in both lungs and large effusion in the right pleural cavity. (B) CR indicated a large amount of diffuse patchy exudation in both lung fields on the 4th day. (C and D) Chest CT scans showed dense shadow and consolidation were diffused in both lungs on the 12th day. (E and F) on the day before discharge day, CR showed exudation and consolidation still existed in large areas of the lungs.
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CMV levels increased (Table 1). CT showed that both lungs were white with pneumothorax and pleural effusion (Figure 2C and D). CR showed that the lungs were still exuding severely (Figure 2E and F).
PMC9253620_03
Timeline of the patient's clinical manifestations and treatment.
IDR-15-3417-g0001.jpg
PMC9253620_03_IDR-15-3417-g0001.jpg
f0001
TMP-SMX (120 mg/kg dose Q6H) combined with CAS (14.4 mg, QD) as well as MEM (100 mg Q8H) was continued for 11 days (Figure 1).
Imaging data of lungs. (A) on the 1st day of admission, CR showed exudation in both lungs and large effusion in the right pleural cavity. (B) CR indicated a large amount of diffuse patchy exudation in both lung fields on the 4th day. (C and D) Chest CT scans showed dense shadow and consolidation were diffused in both lungs on the 12th day. (E and F) on the day before discharge day, CR showed exudation and consolidation still existed in large areas of the lungs.
IDR-15-3417-g0002.jpg
PMC9253620_04_IDR-15-3417-g0002.jpg
f0002
CMV levels increased (Table 1). CT showed that both lungs were white with pneumothorax and pleural effusion (Figure 2C and D). CR showed that the lungs were still exuding severely (Figure 2E and F).
Blood mGNS gene sequence coverage depth map for PJ (A) and CMV (B); sputum mGNS gene sequence coverage depth map for PJ (C) and CMV (D). Multiple Mapping: Multiple comparing 2 or more species. Unique Mapping: unique comparison to a certain species. Identity: the identity of the sequence compared to the reference genome. The abscissa is the size and location of the genome; the ordinate on the left is the number of sequenced sequences of the reference genome; the ordinate on the right is the consistency of the sequenced sequence with the reference genome. Peak map of PJ nucleic acid by Sanger sequencing (E).
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The other microorganisms detected by mNGS are listed in Table 1, which were mainly common bacteria and were not considered to be the cause of invasive lung infections. The genomic coverage depth map of the sequence obtained by mNGS is shown in Figures 3A-D. We also verified PJ infection by Sanger sequencing (Figure 3E).
PMC9253620_04
Imaging data of lungs. (A) on the 1st day of admission, CR showed exudation in both lungs and large effusion in the right pleural cavity. (B) CR indicated a large amount of diffuse patchy exudation in both lung fields on the 4th day. (C and D) Chest CT scans showed dense shadow and consolidation were diffused in both lungs on the 12th day. (E and F) on the day before discharge day, CR showed exudation and consolidation still existed in large areas of the lungs.
IDR-15-3417-g0002.jpg
PMC9253620_04_IDR-15-3417-g0002.jpg
f0002
CMV levels increased (Table 1). CT showed that both lungs were white with pneumothorax and pleural effusion (Figure 2C and D). CR showed that the lungs were still exuding severely (Figure 2E and F).