PMC3966260_01
PMC3966260_02
PMC3966260_03
Graphic summary of biochemical liver injury with administration of adalimumab in Subject 3. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).
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fig1
She was found to have elevated liver enzymes, with ALT 184 and AST 167 (Figure 1). After six weeks of drug discontinuation, liver enzymes normalized (Figure 1).
Liver biopsy showing portal inflammation in Subject 3 (hematoxylin and eosin stain, magnification x200).
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fig2
Also, histologically, occasional lymphocytic infiltrates of the bile duct epithelium were seen, focally resembling a florid ductal lesion (Figures 2 and 3).
Liver biopsy showing lymphocytic and plasma cell infiltrate in Subject 3 (hematoxylin and eosin stain, magnification x400).
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fig3
Also, histologically, occasional lymphocytic infiltrates of the bile duct epithelium were seen, focally resembling a florid ductal lesion (Figures 2 and 3).