PMC9098366_01
(a) Low-power examination reveals Schwannian cells arranged in loose fascicles, surrounded by eosinophilic stroma with Verocay bodies (40x). (b) Higher power examination shows the bland Schwannian cells set in a loose collagenous stroma with hyalinized vessels (200x). Schwannian cells are positive for (c) SOX-10 (200x) and (d) S100 (200x).
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fig1
Microscopic examination reveals fragments of a benign nerve sheath tumor comprised of Schwannian cells arranged in loose fascicles set in an eosinophilic stroma with occasional hyalinized vessels and Verocay bodies, compatible with Schwannoma (Figures 1(a) and 1(b)). Immunohistochemical stains are performed and show that the tumor cells are diffusely positive for S100 and SOX-10 in the Schwannoma component (Figures 1(c) and 1(d)).
(a) Separate fibrous fragment with psammomatous calcifications and vague bland spindled to ovoid cells is shown. This fragment is negative for (b) SOX-10 and positive for (c) EMA and (d) SSTR2A (all images at 100x).
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fig2
Also present was a small separate fibrous fragment with psammomatous calcifications and vaguely nested bland spindled to ovoid cells with focal crush artifact (Figure 2(a)). The small fibrous fragment, on the other hand, is negative for SOX-10 (Figure 2(b)) and shows weak staining for S100 while PR and CD34 show patchy weak staining and EMA and SSTR2A are positive (Figures 2(c) and 2(d)) thus compatible with a meningothelial origin.