PMC5412178_01
Overview of the control scans prior to the introduction of FT (A) CT scan of diffuse astrocytoma, (B) NMRI after the completed oncology treatment indicates the 5 mm recurrence, (C) 11 mm recurrence, (D) tumour progression.
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F1
The scan showed a well-limited tumour mass without necrosis, located to the left frontotemporoparietally, dimensions: 56 x 45 x 51 mm (Figure 1A). A control scan using nuclear magnetic resonance (NMR) technique, performed in April 2012 (Figure 1B), showed the presence of local recurrence, with a diameter of 5 mm, and the scan in September 2012 showed an increase in the tumour to 11 mm (Figure 1C). In February 2013, due to the weakness of the right limbs and speech disturbances, an emergency NMRI was performed, with added contrast (contrast media: gadoteric acid, 0.2 ml/kg), and found the presence of an extensive brain oedema and recurrent tumour, 40 mm in diameter, which was spreading towards the basal ganglia, and a midsagittal plane shifted approximately 9 mm to the right (Figure 1D).
Overview of the control NMRI following the introduction of FT (A) Control scan upon the completion of the combined treatment with TMZ and FT and the regression of the tumour, (B, C and D) continuation of regression to the point of complete absence of clinical and radiological signs of tumour, achieved only with the FT.
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F2
A control NMRI performed in October 2013 showed that there had been a regression of the tumour, with the diameter being 22 mm at the time (Figure 2A). FT. The only pharmaceutical drugs she continued to take were anti-epileptics. Subsequent control scans, performed in February and October 2014, showed a tumour regression (Figures 2 B and 2C). Finally, 30 months after the introduction of the FT, the tumour could not be detected on the control scan from 31 August 2015, and the irregular dotted area that post-contrastly raised the signal intensity, was recognized by a physician as a scar of surgery from 2011 (Figure 2D).