PMC5881413_01
CT chest at presentation (Fig. 1a and b) showing numerous, bilateral lung nodules of varying size and CT chest after 15 weeks of treatment (Fig. 1c and d) showing significant reduction in the size and number of pulmonary lesions, but not yet complete resolution.
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Chest x-ray (CXR) and computed tomography (CT) chest revealed numerous bilateral lung nodules (>50) ranging in size from a few millimetres to several centimetres in diameter and also mediastinal and hilar lymphadenoapthy (Fig. 1a and b). Repeat CT chest at 15 weeks showed significant reduction in the size and number of pulmonary lesions (Fig. 1c and d).
Histopathology of CT-guided biopsy of lung nodule from left lower lobe. a: H&E section demonstrating tissue necrosis with cryptococci (eosinophilic, thin-walled, round yeast forms surrounded by a polysaccharide capsule). b: Yeast cells are positive for D-PAS stain.
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Histology of a CT-guided biopsy of a lung nodule showed yeasts in a background of chronic inflammation (Fig. 2a and b).