PMC3797651_01
Findings at presentation. (A) Fundus photograph of right eye. An orange-yellow mass is shown at the inferotemporal side. (B) Fundus photograph of left eye. A yellow-white mass is shown at the superior side. (C) Early frame and (D) late frame of fluorescein angiogram of left eye. Note hyperfluorescence in the tumor region from the early phase to late phase.
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f1-opth-7-2003
Fundus examination revealed an orange-yellow mass that was 8 disc diameter (DD) in size with no measurable height at the inferotemporal side of the fundus OD, and a yellow-white mass 12 DD in size and 4.8 mm in height at the superior side of the fundus OS (Figure 1A and B). Fluorescein angiography of the left eye showed hyperfluorescence inside the mass from early to late phase (Figure 1C and D).
Histopathology of the tumor from a breast biopsy. Foci of oval and spindle-shaped cells are shown in alveolar and palisading arrangement.. Notes: Hematoxylin and eosin staining; scale bar =100 mum.
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f2-opth-7-2003
Histopathology of the tumor from a breast biopsy revealed foci of oval and spindle-shaped cells in alveolar and palisading arrangement (Figure 2), and that from a lung biopsy showed oval hypertrophic nuclei and proliferation of atypical epithelial cells in rosette-like arrangement.
Findings at 15 months after presentation. (A) Fundus photographs of right eye and (B) left eye. The choroidal tumors are shown. The tumors have apparently enlarged in size compared with size at presentation. (C) Early frame and (D) late frame of indocyanine green angiogram of right eye. Choroidal vessels inside the tumor are stained from the early phase, with a mixture of hyperfluorescence and hypofluorescence in the late phase.
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f3-opth-7-2003
The left optic disc was invisible because of the enlarged mass, and best-corrected visual acuity was reduced to hand motion (Figure 3A and B). An indocyanine green angiogram of the right eye showed choroidal vessel staining inside the mass from the early phase, and a mixture of hyper- and hypofluorescence in the late phase (Figure 3C and D).
Findings after photodynamic therapy of right eye and external radiation therapy of left eye. (A) Fundus photograph of right eye 5 months after photodynamic therapy. The choroidal tumor at the inferior-temporal side has decreased in size compared with size before therapy. (B) Fundus photograph of left eye 5 months after external radiation therapy. The choroidal tumor has decreased in size and the optic disc is visible.
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f4-opth-7-2003