PMC4880811_01
Detection of a somatic KRAS mutation (c.35G > T; p.G12V) in DNA extracted from micro-dissected tumor cells from the patient with recurrent low-grade serous carcinoma. DNA extracted from micro-dissected adjacent stromal cells was used as normal control. Sequencing chromatograms were generated using PCR Sanger sequencing with AB3730XL sequencer
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PMC4880811_01_40661_2016_26_Fig1_HTML.jpg
Fig1
This revealed a KRAS mutation (Fig. 1).
Computerized tomography (CT) scans showing a decrease in an implant close to the hepatic flexure of the colon after the patients have started taking selumetinib since June 2008
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PMC4880811_01_40661_2016_26_Fig2_HTML.jpg
Fig2
An implant close to the hepatic flexure of the colon had a measurement of 1.8 cm (Fig. 2a). Subsequent CT imaging scan done in June 2009 showed sufficient change in her measurable disease, including the previous hepatic flexure implant (0.9 cm, Fig. 2b) to register a partial response.