PMC5288508_01
Patient 1. (a), (c), (e), and (g): right eye. (b), (d), (f), and (h): left eye. (a) and (b): fundus examination showing small pigment epithelium alterations in the foveal area without obvious vascular abnormalities. (c), (d), (e), and (f): fluorescein angiography (min and min) showing perifoveal telangiectasia with late intraretinal staining. (g) and (h): spectral-domain optical coherence tomography (B-scan) showing cystoid macular edema with a central macular thickness measured to 312 mum on the right eye and to 345 mum on the left eye. (i) and (j): autofluorescence images were unremarkable.
CRIOPM2017-5395069.001.jpg
PMC5288508_01_CRIOPM2017-5395069.001.jpg
fig1
Fundus examination revealed small pigment epithelium alterations in the foveal area without capillary abnormalities or dilatations on both eyes (Figures 1(a) and 1(b)). FA confirmed also the absence of late staining of the optic disc and the absence of vein abnormalities excluding an Irvine-Gass syndrome or a branch retinal vein occlusion (Figures 1(c), 1(d), 1(e), and 1(f)). SD-OCT (Spectralis Heidelberg Engineering, Germany) showed cystoid macular edema with a central macular thickness measured to 312 mum RE and to 345 mum LE (Figures 1(g) and 1(h)). Autofluorescence images were unremarkable on both eyes (Figures 1(i) and 1(j)).
PMC5288508_02
Patient 2. (a), (c), (e), and (g): right eye. (b), (d), (f), and (h): left eye. (a) and (b): fundus examination showing perifoveal exudates with small perifoveal capillary abnormalities on both eyes and a photocoagulation scar in the temporal area in the left eye. (c), (d), (e), and (f): fluorescein angiography (min and min) showing perifoveal telangiectasia mainly located in the superior and temporal area in the right eye and in the inferior and temporal area in the left eye with late intraretinal staining. (g) and (h): spectral-domain optical coherence tomography (B-scan) showing cystoid macular edema on both eyes with subretinal fluid in the right eye with a central macular thickness measured to 538 mum on the right eye and to 334 mum on the left eye. (i) and (j): autofluorescence images revealed in RE some hypoautofluorescent lesions in the temporal and inferior macular area, with a stellar distribution corresponding to the exudates. In the LE, the autofluorescence images revealed a large hypoautofluorescent lesion in the temporal area coexisting with smaller ones in the inferior area corresponding to photocoagulation scars.
CRIOPM2017-5395069.002.jpg
PMC5288508_02_CRIOPM2017-5395069.002.jpg
fig2
Fundus examination revealed perifoveal exudates with small perifoveal capillary abnormalities on both eyes (Figures 2(a) and 2(b)). Left eye examination showed also photocoagulation scar in the temporal area (Figure 2(b)). FA (FA; Spectralis, HRA, Heidelberg Engineering, Germany) revealed perifoveal telangiectasia mainly located in the superior and temporal area in the RE and in the inferior and temporal area in the LE with late intraretinal staining corresponding to the angiographic cystic macular edema (Figures 2(c), 2(d), 2(e), and 2(f)). FA examination confirmed the presence of telangiectasia in the anterior periphery and also the absence of vein abnormalities excluding a branch retinal vein occlusion. SD-OCT (Spectralis Heidelberg Engineering, Germany) showed cystoid macular edema on both eyes with subretinal fluid in the RE and central macular thickness was measured to 538 mum on RE and to 334 mum LE (Figures 2(g) and 2(h)). In the LE, the autofluorescence images revealed a large hypoautofluorescent lesion in the temporal area coexisting with smaller ones in the inferior area corresponding to photocoagulation scars (Figures 2(i) and 2(j)).