PMC8172285_01
(a) 4x magnification of the results of upper endoscopy biopsy showing nonspecific chronic inflammatory infiltrate with a thickened subepithelial collagen table. (b) 20x magnification higher-power image of the thickened subepithelial collagen table, showing diagnostic features of entrapped cellular elements such as inflammatory cells and blood vessels.
CRII2021-5574944.001.jpg
PMC8172285_01_CRII2021-5574944.001.jpg
fig1
An endoscopy was performed, and biopsies showed collagenous gastritis (Figure 1).
(a) 10x magnification of histopathology of the polypoid gastric body lesion showing poorly differentiated adenocarcinoma with surface ulceration. (b) High-power magnification of the gastric polypoid lesion showing high-grade dysplasia. (c) EBV-infected carcinoma cells (black stain present) juxtaposed with normal gastric glandular mucosa (black stain absent), using EBV-related encoded RNA in situ hybridization assay (EBER ish).
CRII2021-5574944.002.jpg
PMC8172285_01_CRII2021-5574944.002.jpg
fig2
Eight years later (2020), his screening endoscopy showed a new polyp that, on biopsy, revealed poorly differentiated gastric adenocarcinoma that was positive for EBV (Figure 2).