PMC3504268_01
PMC3504268_02
PMC3504268_03
PMC3504268_04
PMC3504268_05
(a) A 29-year-old man had hypopigmented, finely wrinkle, slightly scaly patches without telangiectasia or induration on bilateral forearm and trunk. (b) Similar lesions on thigh bilaterally. (A) Before therapy and (B) complete clinical response after 30 sessions of PUVA (patient 2).
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fig2
PUVA showed CR in patient 2 (Figures 2(a) and 2(b)).
(a) A 30-year-old woman had hypopigmented patches on sunlight covered body sites. Note these patches extend to neck and (b) breast which is less likely in progressive macular hypomelanosis. (A) before therapy (B) showing almost complete clinical response after 40 sessions of narrow-band UVB. Note some hypopigmented lesions persist under the chin and neck (patient 4).
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fig4
Narrow-band UVB showed CR in patients 1 and 4 (Figures 4(a) and 4(b)), and PR in patient 5 (Figure 5) within 30-48 sessions.
A 29-year-old woman showing hypopigmented skin patches on thigh after 32 sessions of narrow band-UVB therapy (patient 5).
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fig5
Narrow-band UVB showed CR in patients 1 and 4 (Figures 4(a) and 4(b)), and PR in patient 5 (Figure 5) within 30-48 sessions.
(a) The skin biopsy from buttocks (patient 3) shows extensive epidermal changes with marked epidermotrophism of lymphocytes (Hematoxylin-eosin stain, original magnification x100). (b) Greater magnification highlights atypical lymphocytes and formation of numerous (>3) Pautrier's microabscesses (H&E stain, 400x).
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fig6
Three cases (patients 1, 3, and 5) showed extensive changes with marked epidermotrophism of atypical lymphocytes and formation of numerous (>3) Pautrier's microabscesses (Figures 6(a) and 6(b)).
Atypical lymphocytes showing epidermotropism and formation of Pautrier's microabscesses (H&E stain, 400x) (patient 2).
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fig7
The epidermal changes in other two were not so extensive with formation of at least one microabscess (Figures 7 and 8).
Aypical lymphocytes in lacunae in the epidermis (H&E stain, 400x) (patient 4).
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fig8
The epidermal changes in other two were not so extensive with formation of at least one microabscess (Figures 7 and 8).