PMC3504292_01
Ulcerative plaque on the dorsal foot, the blue elliptical line indicates the site of the biopsy (a), multiple ulcerative nodules behind the lateral malleolus (b), microscopic view of septal and lobular panniculitis H&E stain x100 (c).
CRIM.DM2012-612434.001.jpg
PMC3504292_01_CRIM.DM2012-612434.001.jpg
fig1
Dermatological examination revealed a large ulcerative plaque on the dorsal aspect of the left foot surrounded by two satellite purple papules (Figure 1(a)). In addition to multiple grouped dusky erythematous nontender ulcerative nodules behind the lateral malleolus of the left leg (Figure 1(b)). These changes even involved the panniculus causing septal and lobular panniculitis (Figure 1(c)).
PMC3504292_02
Microscopic view of septal and lobular panniculitis H&E x400 (a), dermal foci of intra and extracellular LT bodies H&E x1000 (b), non-metachromatic LT bodies Gimesa stain x1000 (c).
CRIM.DM2012-612434.002.jpg
PMC3504292_02_CRIM.DM2012-612434.002.jpg
fig2
The fatty lobules and its septa were infiltrated by lymphocytes, histiocytes, and plasma cells causing both septal and lobular panniculitis (Figure 2(a)). Aggregations of high number of LT bodies were seen mainly inside of macrophages of the superficial dermis stained by H&E (Figure 2(b)). Gimesa stain confirmed the presence of the non-metachromatic nuclei of the LT bodies (Figure 2(c)).