PMC6201621_01
PMC6201621_02
Radiological findings: A) bladder ultrasonography T: tumor; F: Foley catheter; B) non-contrast-computed tomography image, lymph node swelling (asterisks); C) JJ stent after transurethral resection
PAMJ-30-134-g001.jpg
PMC6201621_02_PAMJ-30-134-g001.jpg
f0001
Mild dilatation was observed in the left kidney and an approximately four cm mass in the left lateral wall of the bladder were observed at CT (Figure 1).
Histological examination: tumoral tissue with intense cellularity in a loose vascularized stroma, hematoxylin-eosin staining, x200; B) diffuse areas of necrosis and hemorrhage in the tumor, x100; C) synaptofizin positive, x400; D) chromogranin A positive, x200; E) CD56 positive, x400; F) CD44 negative, x400)
PAMJ-30-134-g002.jpg
PMC6201621_02_PAMJ-30-134-g002.jpg
f0002
Immunohistochemically, the tumor neuroendocrine tumor differentiation markers CD56, chromogranin A and synaptophysin were positive while CD44 was negative, exhibiting neuroendocrine differentiation (Figure 2, Figure 3).
Large numbers of atypical mitotic figures in all fields (indicated by an arrow), hematoxylin-eosin staining, x400
PAMJ-30-134-g003.jpg
PMC6201621_02_PAMJ-30-134-g003.jpg
f0003
Immunohistochemically, the tumor neuroendocrine tumor differentiation markers CD56, chromogranin A and synaptophysin were positive while CD44 was negative, exhibiting neuroendocrine differentiation (Figure 2, Figure 3).