PMC7350519_01
Multiple papulonodular skin lesions with predilection for cheeks.
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F1
On physical examination at admission, disseminated, single, pearly yellow nodules localized on the face, trunk, and extremities (Figure 1); bruises; and significant hepatosplenomegaly were found.
Histiocyte proliferation in the bone marrow of patient in remission of acute lymphoblastic leukemia (ALL); magnification, x1,000.
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F2
Bone marrow examination confirmed persistent complete remission with negative MRD of <0.01%; however, an increased number of histiocytes with hemophagocytosis (Figures 2, 3) was seen in bone marrow.
Hemophagocytosis in bone marrow; magnification, x1,000.
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F3
Bone marrow examination confirmed persistent complete remission with negative MRD of <0.01%; however, an increased number of histiocytes with hemophagocytosis (Figures 2, 3) was seen in bone marrow.
Skin biopsy revealed diffuse infiltration by histiocytes positive for CD45 and CD68 and negative for S100 and CD1a. Hematoxylin-eosin stain; magnification, x10.
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F4
Skin biopsy revealed diffuse infiltration by histiocytes expressing CD45 and CD68 but negative for CD1a, langerin, and S100 (Figure 4); thus, JXG was recognized.