PMC2990339_01
The high grade UES of the ovary is composed of dedifferentiated round and oval to spindled cells. The nuclei are polymorphous; vesicular with coarse chromatin and large nucleoli; the cytoplasmata are scant. Mitotic figures are readily identified (H&E, x400).
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fig1
Their nuclei were polymorphous vesicular with coarse chromatin and large nucleoli (Figure 1).
Areas with smaller and more monotonous cells are observed focally (H&E, x400).
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fig2
There were transitions to areas with rather monotonous cells (Figure 2).
Endometrium-like glands corresponding to ovarian endometriosis were surrounded by broad fibrous stroma with macrophages (x100).
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fig3
Adjacent to the tumor tissue endometrium-like glands corresponding to ovarian endometriosis were found, surrounded by broad fibrous stroma with macrophages; there was no condensation of tumor cells around endometriotic glands "periglandular collaring" or polypoid intraluminal projections by the sarcoma (Figure 3). 
Tumor cells of high grade ovarian UES show focal strong immunostaining for CD10 (x400).
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fig4
Immunohistochemically, tumor cells showed diffuse strong reactivity for vimentin and patchy strong staining for CD10 in about 50% of cells (Figure 4); there was no staining of tumor cells for AE1/AE3, desmin, S-100, LCA, CD20, c-kit, and CD31.