PMC5772065_01
Light photomicrographs of liver sections. (A) The lobules reveal lobular inflammation by a mixed infiltrate, including lymphocytes and neutrophils, with cholestasis, hepatocyte swelling, centrilobular hepatocyte dropout, and scattered apoptotic hepatocytes (hematoxylin and eosin stain). (B) Some portal tracts contain a mild, mixed inflammatory infiltrate. There is focal interlobular bile duct injury in association with ductular reaction and accompanying neutrophils (hematoxylin and eosin stain). (C) Trichrome stain highlights areas of centrilobular dropout but shows no evidence of advanced fibrosis. (D) Periodic acid-Schiff stain is negative for diagnostic inclusions.
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F1
He underwent a liver biopsy (Figure 1), which revealed no evidence of advanced fibrosis but did show lobular inflammation with cholestasis, centrilobular hepatocyte dropout, and apoptotic hepatocytes.