PMC9597019_01
A PET-CT scan showed a lesion about 0.7 cm in diameter above the right thigh.
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In addition, PET-CT examination showed soft tissue nodules in front of the right femur, about 0.7 cm in diameter, with increased expression of somatostatin receptors: it is likely to be a phosphaturic mesenchymal tumor (Figure 1).
Representative images of histology and immunohistochemistry of case 1. (A and B) H&E
(10xand 4x) highlighted bland spindle cells, smudgy/grungy basophilic matrix and hemorrhage.
(C) H&E (10x) showed focal ossification. (D) Immunohistochemistry (20x) demonstrated
positive staining for FGF-23 in tumour cells.
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The histology of the postoperative specimens showed that the tumor was composed of bland short spindle cells, smudgy/grungy basophilic matrix, mature adipose tissue, hemorrhage, and focal ossification (Figure 2).
PMC9597019_02
A PET-CT scan showed a lesion about 1.5 cm x 1.8 cm in size above the right thigh.
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And PET-CT showed a slightly low-density nodule in the inner muscle of the right middle thigh, about 1.5 cm x 1.8 cm in size, with increased expression of somatostatin receptors: the possibility of phosphaturic mesenchymal tumor (Figure 3).
Representative images of histology and immunohistochemistry of case 2. (A and B) H&E
(20x and 10x) highlighted bland spindle cells, multinucleated giant cells and focal myxoid
changes. (C) H&E (4x) showed hemangiopericytomatous-like blood vessels and smudgy/grungy
basophilic matrix. (D) Immunohistochemistry (20x) demonstrated positive staining for FGF-23
in tumor cells.
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Smudgy/grungy basophilic matrix, hemangiopericytomatous-like blood vessels, a small number of thick walled vessels, a little adipose tissue, hemorrhage, focal ossification, multinucleated giant cells, and focal myxoid degeneration could be seen (Figure 4).Immunohistochemical staining showed positive for vimentin, SATB2, and CD56, but negative for CD31, CD34, desmin, CD99, Bcl-2, S-100, Syn, CK-pan, and STAT6.