PMC10404823_01
A) Duodenal biopsy specimen showing flattening of the villous architecture increased lymphocytes in the surface epithelium (H&E Stain 100x magnification). B) CD3 stain of the duodenal biopsy specimen highlighting the showing a clear decrease in villous height/crypt depth ratio and marked intraepithelial lymphocytosis, exceeding 25IEP/100EC at the tips of the remaining villi (CD3 stain 100x magnification)
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F1
Figure 1). Following UGIE and the finding of a flat duodenal mucosa, the patient was recommended to start with a strict gluten-free diet (GFD) under dietitian's guidance as she was highly suspicious for seronegative coeliac disease.