PMC9684098_01
Baseline color fundus photographs (a and b) showing perifoveal areas of hypopigmentation, corresponding to hyporeflective lesions seen on infrared reflectance images (c and d).
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Upon slit lamp examination and fundus photography, hypopigmented perifoeval areas (OU) were detected (Fig. 1a and b ). Infrared reflectance (IR) imaging showed two perifoveal hyporeflective lesions (OD) - One superotemporal (wedge-shaped) and the other inferior and inferotemporal to the fovea (Fig. 1c, Fig. 2a ) - And a diffuse perifoveal semi-circular hyporeflective lesion (OS) extending from the inferonasal axis to the superotemporal axis (Fig. 1d, Fig. 2d).
Cross-sectional optical coherence tomography scans at baseline (b and e; OD and OS), showing areas of outer plexiform layer thickening, outer nuclear layer thinning, and disruption of ellipsoid zone, and upon 2-week follow-up visit (c and f; OD and OS), showing partial improvement of abnormalities (c and f; OD and OS), corresponding to the section shown on en face scans (a and d; OD and OS, respectively).
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OCT (SD-OCT) showed OPL thickening, ONL thinning, and disruption of the ellipsoid zone in areas corresponding to the lesions (OU) (Fig. 2b and e). OCT angiography indicated no flow abnormality at superficial/deep retinal vasculature or choriocapillaris. SD-OCT scan also showed partial improvement at the pathology sites (Fig. 2c and f).