PMC8438150_01
(A-G): Case 1: Day 1: axial MRI, T1-weighted with contrast (A), FLAIR-sequence (B), CT-scan (C) show a left frontal white matter lesion (big arrows) with rim contrast enhancement (arrowheads) and midline shift; Day 2 (D): CT-scan: progressive edema; Day 15 (E,F): CT-scan: bleedings (small arrows); Day 80 (G): reimplantation of bone plate. (I-IV): Histopathology of the brain biopsy (Case 1). Multiple perivascular bleedings [(I), HE-stain], fibrin accumulation [(II), Ladewig-stain], demyelinization [(III), LFB-PAS] and granulocystic infiltration [(IV), Chloracetatesterase]. (a-c): Case 2: Day 3: axial MRI, FLAIR-sequence (a) shows a subcortical left temporooccipital white matter lesion (big arrows) with midline shift and multiple hemorrhages (arrowheads) in SWAN-sequence (b,c).
fneur-12-673611-g0001.jpg
PMC8438150_02_fneur-12-673611-g0001.jpg
F1
The lesion was located predominantly subcortical without affecting the temporal pole, typical for AHLE (Figures 1a-c).
PMC8438150_02
(A-G): Case 1: Day 1: axial MRI, T1-weighted with contrast (A), FLAIR-sequence (B), CT-scan (C) show a left frontal white matter lesion (big arrows) with rim contrast enhancement (arrowheads) and midline shift; Day 2 (D): CT-scan: progressive edema; Day 15 (E,F): CT-scan: bleedings (small arrows); Day 80 (G): reimplantation of bone plate. (I-IV): Histopathology of the brain biopsy (Case 1). Multiple perivascular bleedings [(I), HE-stain], fibrin accumulation [(II), Ladewig-stain], demyelinization [(III), LFB-PAS] and granulocystic infiltration [(IV), Chloracetatesterase]. (a-c): Case 2: Day 3: axial MRI, FLAIR-sequence (a) shows a subcortical left temporooccipital white matter lesion (big arrows) with midline shift and multiple hemorrhages (arrowheads) in SWAN-sequence (b,c).
fneur-12-673611-g0001.jpg
PMC8438150_02_fneur-12-673611-g0001.jpg
F1
The lesion was located predominantly subcortical without affecting the temporal pole, typical for AHLE (Figures 1a-c).