PMC3914224_01
Renal graft biopsies. In case 1, histological findings were irrelevant; no viral inclusions were identified by light microscopy (H&E (a) and (b)) or immunohistochemistry. Renal biopsy of case 2 demonstrated focal interstitial necrotizing granulomata with neutrophils, plasma cells, and lymphocytes ((c) H&E and (d) PAS stain); note that the glomeruli are not affected. Control graft biopsy only demonstrated minimal interstitial fibrosis ((e) PAS stain and (f) Masson trichromic stain).
CRIM.NEPHROLOGY2013-195753.001.jpg
PMC3914224_02_CRIM.NEPHROLOGY2013-195753.001.jpg
fig1
A graft biopsy was also performed revealing histopathological findings consistent with adenovirus nephritis (Figures 1(c) and 1(d)). PCR for adenovirus were negative on two subsequent determinations (Figure 3). Posterior SCr determination decreased to 1.4 mg/dL, and a control graft biopsy performed 2 months after discharge showed less than 5% of interstitial fibrosis, without inflammatory infiltrate or other acute change (Figures 1(e) and 1(f)).
Case 1: correlation of SCr, leukocytes, and treatment administration.
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fig2
B19 antigenemia has remained negative. Blood and urine real-time PCR for adenovirus has remained negative in 3 serial subsequent determinations (Figure 2).
PMC3914224_02
Renal graft biopsies. In case 1, histological findings were irrelevant; no viral inclusions were identified by light microscopy (H&E (a) and (b)) or immunohistochemistry. Renal biopsy of case 2 demonstrated focal interstitial necrotizing granulomata with neutrophils, plasma cells, and lymphocytes ((c) H&E and (d) PAS stain); note that the glomeruli are not affected. Control graft biopsy only demonstrated minimal interstitial fibrosis ((e) PAS stain and (f) Masson trichromic stain).
CRIM.NEPHROLOGY2013-195753.001.jpg
PMC3914224_02_CRIM.NEPHROLOGY2013-195753.001.jpg
fig1
A graft biopsy was also performed revealing histopathological findings consistent with adenovirus nephritis (Figures 1(c) and 1(d)). PCR for adenovirus were negative on two subsequent determinations (Figure 3). Posterior SCr determination decreased to 1.4 mg/dL, and a control graft biopsy performed 2 months after discharge showed less than 5% of interstitial fibrosis, without inflammatory infiltrate or other acute change (Figures 1(e) and 1(f)).
Case 2: correlation of SCr, leukocytes, and treatment administration.
CRIM.NEPHROLOGY2013-195753.003.jpg
PMC3914224_02_CRIM.NEPHROLOGY2013-195753.003.jpg
fig3
PCR for adenovirus were negative on two subsequent determinations (Figure 3). Posterior SCr determination decreased to 1.4 mg/dL, and a control graft biopsy performed 2 months after discharge showed less than 5% of interstitial fibrosis, without inflammatory infiltrate or other acute change (Figures 1(e) and 1(f)).