PMC4153201_01
Histological examination of the infiltrated bronchial mucosa with Haematoxylin-Eosin staining: amorphous eosinophilic deposition
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Biopsy of the bronchial infiltration was examined with Hematoxylin-Eosin staining and showed amorphous eosinophilic deposition in the mucosa (Figure 1).
Histological examination of the infiltrated bronchial mucosa under polarized light with Congo Red staining: green- yellowish amyloid deposition.
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Specimen examination under polarized light with Congo Red staining revealed green- yellowish amyloid deposition predominating in the vessel walls (Fig. 2).
Histological examination of the infiltrated bronchial mucosa with immunochemical study: positive amyloid deposition by the anti-lambda antibody.
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Histochemical study revealed lambda light chains (Fig. 3).
Chest CT scan: bilateral broncho-vascular thickening, narrowing the proximal bronchi diameter, calcified mediastinal lymphadenopathies and pulmonary nodules.
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Chest CT scan revealed bilateral broncho-vascular thickening narrowing the proximal bronchi diameter, collapsed middle lobe, numerous pulmonary nodules with many calcified ones, collapsed left lower lobe, septal thickening of both lower lobes and lymphadenopathies of the interbronchial, hilar and mediastinal chains with central and peripheral calcifications (Fig. 4).
Histological examination of salivary glands with immunohistochemical study: positive amyloid deposition by the anti-lambda antibody.
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Labial biopsy revealed AL amyloidosis associated with chronic sialadenitis type 3 of the Chisholm's classification (Figure 5).