PMC4220425_01
(a) A papillary cluster of tumor cells displaying prominent pseudostratification of nuclei toward the periphery (Papanicolaou, x400). (b) Rosette-like clusters of tumor cells with tall cytoplasm merging toward the lumen. Inset shows singly lying cells with columnar configuration and wispy cytoplasm (Papanicolaou, x400). (c) Prominent nuclear grooves (black arrows) were seen in the fine needle aspiration smears. Inset shows presence of mitotic figures (Papanicolaou, x400). (d) Histologic section of tumor showing trabecular arrangement with presence of pseudostratification and rosette-like structures (black arrow). Inset highlights the same rosette-like structures (H and E, x200)
CJ-11-27-g001.jpg
PMC4220425_01_CJ-11-27-g001.jpg
F1
The papillary fronds, periphery of syncytial fragments as well as the rosette-like clusters of tumor cells showed prominent pseudostratification [Figure 1a] of the nuclei. Many singly lying cells were also seen having a columnar configuration and wispy cytoplasm [Figure 1b, inset]. However, nuclear grooves [Figure 1c] were frequently encountered in the tumor cells. Mitotic figures were seen [Figure 1c, inset]. Rosette like clusters of the tumor cells were also observed having peripherally aligned nuclei and columnar cytoplasmic processes merging toward the center [Figure 1b]. The tumor cells had mostly trabecular arrangement with pseudostratification of nuclei [Figure 1d]. Rosette-like structures were also noted in the broad trabeculae of columnar cells [Figure 1d, black arrow and inset].