PMC5771935_01
(A) Hypercellular bone marrow (>95%) with heavy infiltration by blasts (88%). (B) Reticulin stain (0-3+) showing focal minimal increase in reticulin fibrosis (1+). (C) Bone marrow smear with markedly increased blasts that were positive on flow cytometry (D) for CD10, CD19, CD20, CD22, and TdT.
CCR3-6-155-g001.jpg
PMC5771935_01_CCR3-6-155-g001.jpg
ccr31264-fig-0001
The diagnosis was confirmed by the finding of 88% blasts in a 95% cellular bone marrow (BM, Fig. 1), all of which expressed the B-cell antigens CD19, CD20, and CD22.