PMC4895069_01
47-year-old woman with invasive lobular carcinoma of the left breast. MLO view of the left breast from 1996 shows no abnormality. MLO view of the left breast from 1999 shows an apparent increase in retroglandular fat and retraction of breast parenchyma from the chest wall, hence "shrinking".
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When compared to the previous study (Fig. 1A), mammography of the left breast showed significant retraction of the breast parenchyma from the chest wall with breast tissue no longer overlying the pectoralis muscle on the mediolateral oblique (MLO) view (Fig. 1A). The cranio-caudal (CC) view of the left breast similarly showed an apparent increase in retroglandular fat and retraction of the fibroglandular tissue in the outer central breast (Fig. 1B). In addition, a single small axillary lymph node was seen (Fig. 1A).
PMC4895069_02
47-year-old woman with invasive lobular carcinoma of the left breast. CC view of the left breast from 1996 shows no abnormality. CC view of the left breast from 1999 shows shrinking volume of the outer breast.
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When compared to the previous study (Fig. 2B), mammography revealed "shrinking" of the glandular volume of the entire left breast without any change on physical exam. Sonography showed a large area of ill-defined shadowing (Fig. 2C), and MRI demonstrated a large mass with diffuse enhancement and radiating spicules (Fig. 2D).