PMC2954744_01
Skull CT: Deep-seated cerebral lesion with an irregular outline, mass-effect, peripheral contrast uptake, and central necrosis.- Skull CT: Deep-seated cerebral lesion with an irregular outline, mass-effect, peripheral contrast uptake, and central necrosis.
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A skull computerized tomography (CT) scan showed a deep-seated, irregularly shaped expansive lesion on the right of brain, with peripheral contrast uptake that was impinging on and obstructing the cerebrospinal fluid (CSF) pathways (see Figure 1).
A, B: Histological sections of cerebral tissue showing areas of elongated cells with pleomorphic and hyperchromatic nuclei that are associated with vascular neoformation and extensive hemorrhage and necrosis.- A, B: Histological sections of cerebral tissue showing areas of elongated cells with pleomorphic and hyperchromatic nuclei that are associated with vascular neoformation and extensive hemorrhage and necrosis.. C: Immunohistochemistry positive for GFAP.
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These findings, along with the morphological features and the presence of necrosis, confirmed the diagnosis of GBM (see Figure 2). The patient, whose level of consciousness improved with steroids but whose motor functioning remained impaired, was referred to radiotherapy.
CT (above) and MTI (below): A large lesion impinging on the thalamus and basal ganglia with peripheral contrast uptake and central necrosis.- CT (above) and MTI (below): A large lesion impinging on the thalamus and basal ganglia with peripheral contrast uptake and central necrosis.
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Skull CT and MRI results showed an increase of the lesion size (see Figure 3).