PMC5758937_01
: Clinical outcome and platelet (PLT) count in a ITP patient associated with 3% of a JAK2V617F allele burden (AB) followed ET with 27% of AB after 13 years.
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In March 2004, a 72 year old woman suffering from rheumatoid arthritis, presented with petechiae, ecchymoses, epistaxis and a platelet (PLT) count of 13,000/muL was diagnosed with ITP (Fig. 1).
A: Bone marrow film of ITP diagnosed in 2004 (magnification 20x). Megakaryocytes are diffuse and slightly increased in number, with normal features.. B. Bone marrow trephine of ET diagnosed in 2017 (magnification 20x). Clusters of large to giant mature megacaryocytes with folded nuclei.
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B and C hepatitis, CMV, and HIV were all negative. Bone marrow aspirate showed increased megakaryocytes and normal myeloid/erythroid ratio (Fig. 2A). A bone marrow trephine was performed, showing increased cellularity and several clusters of large to giant mature megacaryocytes with folded nuclei (Fig. 2B).