PMC10080590_01
PMC10080590_02
CT scan of the thorax. (A) Right breast mass, arrowed. (B) Left breast mass, arrowed.
fonc-13-1034556-g001.jpg
PMC10080590_02_fonc-13-1034556-g001.jpg
f1
The mass was abutting the right pectoralis muscles with no clear fat plane at the central region (Figure 1A). A lobulated heterogeneously enhancing mass at the upper inner quadrant of the left breast extended to the retroareolar region, measuring 2.4 x 5.4 x 4.2 cm with calcifications and a necrotic center within (Figure 1B).
Photos of the patient. (A, B) Preoperatively, front and right lateral views. (C) Postoperatively, front.
fonc-13-1034556-g002.jpg
PMC10080590_02_fonc-13-1034556-g002.jpg
f2
The patient underwent bilateral mastectomy and axillary dissection successfully (Figures 2A-C).
Microscopic analysis of the right breast. (A) The right breast tumor shows hypercellularity [hematoxylin-eosin (H&E) staining, x4]. (B) The spindle-shaped cells are arranged in fascicles in a herringbone pattern (H&E, x20). (C) Focal leaf-like pattern typical of phylloides tumor with adjacent necrosis (H&E, x4). (D) The tumor is seen less than 1 mm from the inked deep margin (H&E, x4).
fonc-13-1034556-g003.jpg
PMC10080590_02_fonc-13-1034556-g003.jpg
f3
The right mastectomy specimen weighed 1.2 kg with a maximal diameter of 16 cm and was a malignant phylloides (Figure 3).
Microscopic analysis of the left breast. (A, B) The left breast tumor shows variable morphology of invasive carcinoma comprised of infiltrating small ducts, cords, and cribriform glands with a micropapillary pattern (H&E, x4). (C) Clusters of cells floating in mucin pools (H&E, x4). (D) The malignant cells display pleomorphic vesicular nuclei with inconspicuous nucleoli (H&E, x20).
fonc-13-1034556-g004.jpg
PMC10080590_02_fonc-13-1034556-g004.jpg
f4
It was an invasive carcinoma of no special type (ER positive 60%, PR positive 50%, and HER2 negative) (Figure 4).