PMC9986888_01
Histology of transbronchial biopsy specimen. (a) Hematoxylin-eosin staining, (b) P40, (c) TTF-1, (d) CD56, and (e) chromogranin A staining by immunohistochemistry. Scale bars, 200 microm.
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Pathological analysis of a resected specimen obtained by bronchoscopy revealed a keratinizing tendency; in addition, p40 was positive, and thyroid transcription factor-1 (TTF-1), synaptophysin, CD56, and chromogranin A were all negative by immunohistochemistry (Figure 1).
Clinical course. Black solid box, terms of radiotherapy; striped box, terms of EGFR-TKIs; Mo, months; CYFRA 21-1, serum cytokeratin-19 fragments.
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Overall, the EGFR-TKIs decreased the size of the cancer alongside stereotactic radiotherapy for the multiple bone metastases (Figure 2).