PMC10343433_01
(Panel A) shows RNS tracking of long episodes over time, which demonstrates a significant increase in long episodes on the day of the higher dose psychedelic mushroom use with 32 long episodes. The x-axis is calendar dates demonstrating the timeline of the occurrence of the episodes. The y-axis is the number of long episodes, with each box representing 10 long episodes. (Panels B, C) provide examples of electrocorticography recordings of two of the long episodes, demonstrating typical seizures. The x-axis is time in seconds, and the y-axis is the relative voltage for each channel. LH, left hippocampus; RH, right hippocampus; numbers 1-4 refer to the depth electrode contact.
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F1
During a routine clinic visit, the review of RNS data demonstrated a significant outlier with 32 long episodes in 1 day (Figure 1).
A photograph showing the dried mushrooms consumed by the patient, which are identifiable as Psilocybe cubensis. He fully consumed the second mushroom from the left on the first day (the day of the seizures), estimated to be 2.5-3.0 g (~20 mg pure psilocybin). On subsequent days, he took smaller amounts, not more than 1.5 g (~10 mg pure psilocybin) at a time, over 1 week.
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F2
The patient identified this as the day he used psychedelic mushrooms recreationally (Figure 2).