PMC3629051_01
(A) Image of the unfixed liver revealed hepatomegaly without gross metastasis. (B) Microscopic examination of the liver revealed diffuse infiltration by pleomorphic cells with some glandular formation. (C) Immunohistochemical staining for E-cadherin expression in the metastatic nodule in the lung was strongly positive, (D) that of metastatic tumor cells in the liver was negative (arrow).
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The liver capsule was smooth, the cut surfaces of which showed non-homogeneous dark brown and yellow tissue and no mass-forming lesions (Fig. 1A). Microscopic examination revealed diffuse infiltration of the liver parenchyma by pleomorphic cells with some glandular formation (Fig. 1B). Notably, tumor cells in the lung nodule strongly expressed E-cadherin (Fig. 1C), while tumor cells in the liver did not (Fig. 1D).