PMC5602683_01
MRI findings at onset of neurological disturbances.. Notes: Brain MRI images from June 2015 showed (A) T2 hyperintense lesions in left temporal lobe and brainstem (circles), (B) T1 hyperintense lesions in basal ganglia (thin arrows), known as calcifications, and (C) leptomeningeal contrast enhancement at midbrain-pons junction (arrow).. Abbreviation: MRI, magnetic resonance imaging.
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She was diagnosed with NPSLE and basal ganglia calcification (Figure 1) and then treated with 1 g methylprednisolone (MPRE) pulses for 5 consecutive days followed by prednisolone (PRE) 60 mg/daily and hydroxychloroquine 400 mg/daily, with relapse during PRE dose reduction when reaching the 7.5 mg/day dosage.
Brain MRI images before and after B-cell depleting therapy.. Notes: Brain MRI images from February 2016 showed extensive and bilateral focal or confluents subcortical and deep WM lesions, hyperintense in long TR sequences, involving (A) semioval centers (S), temporal lobe (*), (B) external capsule, claustrum and subinsular regions (thin arrow) and (C) midbrain (arrow) without contrast enhancement. Moderate subcortical atrophy with dilation of lateral ventricles. Brain MRI in September 2016, 6 months after RTX treatment, showed reductions in numbers and size of hyperintensity lesions in WM, especially in temporal lobes bilaterally (D and E) and brainstem (F).. Abbreviations: MRI, magnetic resonance imaging; WM, white matter; RTX, rituximab.
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Brain magnetic resonance imaging (MRI) confirmed basal ganglia calcifications and showed a dramatic increase in the number and size of previous white matter (WM) lesions (Figure 2) with hyperintensity on diffusion-weighted images and enhanced apparent diffusion coefficient suggesting vasogenic edema (Figure 3). Follow-up MRI revealed remarkable reduction in number and size of WM lesions (Figures 2 and 3).
DWI images before and after B-cell depleting therapy.. Notes: Brain MRI DWI sequences from February 2016 (A and B) showed hyperintensity in right temporal lobe (dashed circles), external capsule and claustrum (dashed ovals) with increased apparent diffusion coefficient (not shown) suggesting vasogenic edema. *Basal ganglia calcification. On September 2016, 6 months after RTX treatment, brain MRI DWI sequences (C and D) showed complete disappearance of edema.. Abbreviations: MRI, magnetic resonance imaging; DWI, diffusion-weighted imaging; RTX, rituximab.
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Brain magnetic resonance imaging (MRI) confirmed basal ganglia calcifications and showed a dramatic increase in the number and size of previous white matter (WM) lesions (Figure 2) with hyperintensity on diffusion-weighted images and enhanced apparent diffusion coefficient suggesting vasogenic edema (Figure 3). Follow-up MRI revealed remarkable reduction in number and size of WM lesions (Figures 2 and 3).