PMC8422449_01
Axial, sagittal, and coronal T1 injected magnetic resonance imaging, with stereotactic radiosurgery planning from the GammaPlan software Elekta Instruments, Inc., version 11.0.3 delivering a 14 Gy at 50% isodose for a 1.9 cm3 pineal region lesion.
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F1
The serum laboratory workup for germ cell tumor markers (alphafetoprotein and beta-HCG) was negative [Figure 1].
Papillary tumor of the pineal region. (1) The vascular axes of neoplastic papillae often harbor multiple capillaries. Neoplastic cells detached from the papillary vascularized core, leading to an apparent clear perivascular space. (2) Cytokeratin AE1-AE3 is diffusely expressed in the epithelial-like neoplastic cells and predominates in perivascular areas.
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F2
Vessels were hyalinized and had a pseudoangiomatous morphology, with multiple lumina and an absence of microvascular proliferation [Figure 2].