PMC8580761_01
Magnetic resonance imaging findings (fluid-attenuated inversion-recovery). (A) Day 34: a high-frequency signal was observed in the occipital white matter. (B) Day 63: extension of the high-frequency signal to the corpus callosum/pons was observed. (C) Day 83: the high-frequency signal in the occipital lobe had expanded further and extended to the frontal lobe.
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Magnetic resonance imaging (MRI) on the same day showed a high-frequency signal in the diffusion-weighted image of the posterior aspect of the periventricular white matter, suggesting reversible occipital leukoencephalopathy, and tacrolimus was discontinued (Fig. 1).
Central autopsy pathological findings. (A) Hematoxylin and Eosin (H&E) staining, low power (10x): congestion and perivascular inflammatory cell infiltration in the cerebral cortex and edema in the white matter were observed. (B) H&E staining, high power (40x): cell infiltration was observed in the Virchow-Robin cavity around the cortical blood vessels. (C) Immunostaining for CD3: infiltration by CD3-positive T cells was observed.
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The autopsy results suggested GVHD (Fig. 2).