PMC7784096_01
(A) Suprarenal mass with hypodense areas displacing the right kidney postero-inferiorly (CT Abdomen axial view); (B) CT Abdomen (coronal view).
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There were hypodense areas within the tumour, representing areas of necrosis (Figure 1A and 1B).
(A) Huge mass measuring 16 cm x 14 cm x 11 cm, weighing 1610.6 g, comparing to the normal right adrenal gland (4.0 cm x 3.5 cm x 1.3 cm); (B) Normal right adrenal measuring 4.0 cm x 3.5 cm x 1.3 cm.
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Both the tumour and right adrenal were removed (Figure 2A and 2B).
(A) Dedifferentiated area composed of diffuse sheets of pleomorphic cells displaying large irregular nuclei with vesicular chromatin, inconspicuous nucleoli and moderate eosinophilic cytoplasm. Numerous bizarre and multinucleated cells are seen (H&E, x40); (B) Fluorescence in situ hybridization (FISH) analysis for MDM2 gene using MDM2/CEP 12 probe (green signal) (VYSIS), shows many nuclei with amplified signals (red signal), i.e., consistent with MDM2 gene amplification.
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Histopathological examination of the tumour revealed a FNCLCC (Federation Nationale des Centres de Lutte Centre Le Cancer) grade 2 dedifferentiated liposarcoma (Figure 3A and 3B).