PMC3932838_01
((a)-(b)) The peripheral blood shows normal mature neutrophils and lymphocytes with normal red blood cell morphology. Rare morphologically normal platelets are identified. (c) The bone marrow aspirate shows a spectrum of normal maturation in erythroid and granulocytic precursors. No abnormal cell population is identified. (d) The bone marrow core biopsy cellularity is appropriate for age. (e) The bone marrow interstitium does not show the presence of megakaryocytes. (f) Immunohistochemistry for CD61, a megakaryocytic antigen, does not show the presence of megakaryocytes on the core biopsy tissue section.
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CD61, consistent with a diagnosis of AAT (Figure 1). Cytogenetic analysis of the bone marrow revealed a normal female karyotype (46,XX).
Patient's platelet counts over 121 days following treatment with ATG and CSP. Displayed in dark and light grey lines are platelets count and CSP levels, respectively.
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By 4 months after initiation of ATG/CSP treatment the platelet level had increased to 115, 000 x 109/L and remained stable thereafter (Figure 2).