PMC3591259_01
Bone marrow biopsy specimen showing CD 20 positive atypical cells in clusters (original magnification X 200) within sinusoids of bone marrow.
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The bone marrow biopsy revealed large atypical CD20 positive lymphoid cells in sharply demarcated clusters restricted to the sinusoids, the cells characterized by markedly irregular nuclei and multiple nucleoli, thus clinching the diagnosis of intravascular large B cell lymphoma (Figure 1a, b & c). Following eight cycles of R-CHOP, the patient has been afebrile and doing well and is considered to be in remission eight months later, with repeat bone marrow biopsy showing disappearance of lymphoma cells (Figure 1d).