PMC4272654_01
High magnification retinography of the left eye reveals several optic disc drusen, as well as bone spicule-shaped pigmentary deposits and sheathing of the retinal blood vessels.
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F1
Fundoscopic examination disclosed large optic disc drusen, cystic macular changes, and retinal pigment epithelium (RPE) clumping and atrophy at the macular region and mid periphery in both eyes, as well as vascular sheathing (Figure 1).
Optic coherence tomography (OCT) before and after topical carbonic anydrase treatment. A and B: Right and left eyes one week after phacoemulsification show diffuse increase in retinal thickness and hyporeflective cystic changes at the inner and outer plexiform layers, as well as a small pocket of subfoveal fluid. Aspect of the scans very similar before surgery (not presented due to very low resolution of the scans). C and D: right and left eye 2 months after topical carbonic anydrase inhibitor four times a day. There is marked decrease in retinal thickness and cystic changes. The anatomical outcome was maintained four months after discontinuation of the treatment.
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F2
Central retinal volume was of 13.65mm3 in the right eye and 10.49mm3 in the left eye (Figures 2A and B). A progressive decrease of macular thickness and of cystic changes, more pronounced at the right eye, was observed during the course of topical CAI treatment, and the central macular thickness improved to 355 +- 12 microns in the right eye (central volume of 10.31mm3) and 361 +- 22 microns in the left eye (central volume of 10.00mm3) (Figure 2C and D).