PMC9702802_01
Timeline of the case and ELISA results of antibodies against ganglioside complexes. (A) The patient started inhaling N2O occasionally 2 years ago, felt numbness and weakness 2 months ago, significantly improved after receiving the treatment of IVIG, and almost recovered 6 months after the admission. (B) ELISA tests indicated the anti-GM1 IgM antibodies were positive in both CSF and serum while anti-GM1 IgG antibodies were negative. IVIG, intravenous immunoglobulin; CSF, cerebrospinal fluid.
fneur-13-1033327-g0001.jpg
PMC9702802_01_fneur-13-1033327-g0001.jpg
F1
The patient was a 20-year-old camgirl without any other medical history and occasionally inhaled N2O for fun in the last 2 years (Figure 1A). IgM antibodies were positive in both serum and CSF while anti-GM1 IgG antibodies were negative (Figure 1B). Intravenous immunoglobulin (0.4g/kg x 5 days) was then given as an additional treatment.