PMC5234270_01
Astroblastoma - Axial NECT (a) shows a heterogenous mass in the right temporal lobe with calcification (arrow). Axial FLAIR (b), T2W (c), and T1W pre-contrast (d) images show T1 & T2 prolongation in the right temporal lobe (arrowheads) and right temporal horn. There is dilation of the right temporal horn (arrow). The T1W post-contrast image (e) shows lesion enhancement and enhancement of cysts (dotted arrow). There is diffusion restriction (arrow) on DWI (f) and ADC (g). The coronal gradient T2* image (h) shows a region of susceptibility artifact compatible with calcification.
SNI-7-1008-g001.jpg
PMC5234270_01_SNI-7-1008-g001.jpg
F1
A large area of gradient susceptibility along the posterior aspect of the lesion represented calcifications [Figure 1].
Astroblastoma Immunohistochemistry - x100, x200, and x400 hematoxylin and eosin (H&E) staining depicting epithelioid cells of the astroblastoma (a-c). x400 H&E staining demonstrating astroblastoma cells with short cytoplasmic processes arranged in perivascular pseudorosettes (d). x400 GFAP+ staining (e). x200 PHH3 positive staining at (f)
SNI-7-1008-g002.jpg
PMC5234270_01_SNI-7-1008-g002.jpg
F2
The neoplasm was positive for glial fibrillary acidic protein (GFAP), synaptophysin, and Olig2; IDH1 was negative, similar to the staining profiles reported in recent literature [Figure 2].