PMC9891144_01
a In gastric mucosa, multiple black nodular lesions were identified with white light. The two largest lesions of 5 mm were present on the distal body. These lesions were suggestive of melanoma metastasis. b Similar black nodular lesion of 3 mm on the duodenum.
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F1
Upper endoscopy was performed showing multiple black nodular lesions in the stomach and duodenum (Fig. 1).
Narrow-band imaging: black patches present on the summit of elevated lesions. The lesions' base showed an enlarged regularly placed oval and elongated pit pattern in contrast to a small pit pattern of the surrounding normal gastric mucosa.
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F2
Narrow-band imaging revealed the presence of black patches on the top of these nodular lesions (Fig. 2).
a Lamina propria diffuse infiltration by epithelioid malignant neoplasia. Haematoxylin-eosin staining. x40. b Tumoural cells show intense and diffuse expression for HMB45. HMB45. x40.
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F3
Histopathological examination showed an epithelioid malignant injury with intense and diffuse HMB45 expression suggestive of pigmented melanoma (Fig. 3).