PMC3489072_01
Microscopy and immunohistochemistry of the SLCT of the right ovary (A-C) and histology of the endometrioid carcinoma of the endometrium (D). (A) Tubular structures lined by Sertoli-type cells with variable number of Leydig cells packed in ribbons or nests between tubules (H and E, x40). (B) Positivity for inhibin of both Sertoli and Leydig cells components of the SLCT (H and E, x40). (C) Positivity for pancitokeratine (H and E, x40). (D) histological appearance of the endometrial neoplasm (H and E, x40).
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Microscopical examination of the neoplasm located in the right ovary revealed a proliferation of tubular structures lined by one layer of cuboidal epithelial cells with Sertoli cell appearance, amphophilic vacuolated clear cytoplasm, oval basal nuclei, and scant nucleoli (Fig. 1A). The intervening stroma contained nests of variable numbers of large monomorphic cuboidal cells with eosinophilic cytoplasm and central located nuclei with the aspect of Leydig cells (Fig. 1A). Immunohistochemistry showed strong positivity of the neoplasm for inhibin and pancytokeratine (Fig. 1B and C) and negativity for vimentine, placental alkaline phosphatase, synaptophysin, cytokeratine 20, and alpha-fetoprotein; less than 5% of tumor cells were positively stained for the proliferation marker Ki67/MIB-1. Concerning the neoplasm found in the endometrium, the diagnosis was endometrioid adenocarcinoma (G2 pT1B/FIGO IA, FIGO 2009 staging) (Fig. 1D).
Effect of salpingo-oophoretomy with hysterectomy on alopecia and hair growth on linea alba. (A) Scalp of the patient before surgery. (B) Scalp of the patient 12 months after surgery. (C) Videodermoscopy of the linea alba before surgery. (D) Videodermoscopy of the linea alba 12 months after surgery.. Note: Red dots indicate hair follicles.
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Twelve months postoperatively, the patient was in good health, alopecia (Fig. 2A and B) and hirsutism (Fig. 2C and D) had substantially improved, and total serum T levels (0.8 ng/mL), delta-4-androstenedione (0.8 ng/mL), and DHEA (1.5 ng/mL) were within the normal range.