PMC10467300_01
Multiple discrete brown smooth nodules distributed over the penis before the treatment (a), most have marked improvement after 2 weeks of treatment of tofacitinib (b), and only hyperpigmentation left behind after 1-month treatment, (c) and the hyperpigmentation disappears 4 months later (d).
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PMC10467300_01_10.1177_20406223231195632-fig1.jpg
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Cutaneous examination revealed multiple discrete brown smooth nodules distributed over the thighs, scrotum, and penis [Figure 1(a)]. Two weeks later, most nodules had marked relief [Figure 1(b)]. Then tofacitinib was reduced to 5 mg daily, leading to complete remission for the lesions with hyperpigmentation left behind after another 2 weeks of treatment [Figure 1(c)]. In a 6-month of follow-up, the hyperpigmentation disappeared without lesional recurrence [Figure 1(d)].
PMC10467300_02
Multiple red nodules on the buttocks (a), showing marked improvement after 1 week of treatment with tofacitinib (b).
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PMC10467300_02_10.1177_20406223231195632-fig2.jpg
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He was diagnosed with scabies and administered topical 10% sulfur ointment alone, twice daily for 3 days, 1 week apart for two cycles, which led to excellent remission for the symptoms and signs except for the nodules on the buttocks [Figure 2(a)]. Then tofacitinib 5 mg, twice daily, was prescribed, which resulted in evident improvement for the nodules after 1-week treatment [Figure 2(b)].
PMC10467300_03
PMC10467300_04
Multiple red nodules on the scrotum (a), showing clearance of nodules after 1 week of treatment with tofacitinib (b).
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PMC10467300_04_10.1177_20406223231195632-fig3.jpg
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He was diagnosed with scabies and was treated with two cycles of topical 10% sulfur ointment, twice daily for 3 days, 1 week apart, which led to excellent response except for some of the pruritic nodules on the scrotum [Figure 3(a)]. Therefore, tofacitinib 5 mg twice daily alone was prescribed for a week, showing excellent response with clearance of nodules [Figure 3(b)].
PMC10467300_05