PMC9046006_01
Colonoscopy showing a 10 mm sessile sigmoid colon polyp.
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fig1
A 67-year-old African American female with a medical history of hypertension, dyslipidemia, diabetes mellitus type II, and chronic kidney disease IIIa underwent age-appropriate average-risk screening colonoscopy which revealed one 10 mm sessile polyp (Paris II-a) in the sigmoid colon (Figure 1).
Sigmoid colon polypectomy showing benign colonic mucosa with hyperplastic changes and submucosal accumulation of eosinophilic materials, which are S100, CD117, CD34, and SMA negative (excluding neuroma, GIST, and leiomyoma) (a). The material is positive for Congo red stain consistent with amyloids (b).
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fig2
Complete polypectomy was performed via hot snare, and histopathology showed colonic mucosa with hyperplastic changes, accompanied by submucosal accumulation of eosinophilic, paucicellular materials positive for Congo red stain, with green birefringence, consistent with amyloids (Figure 2).