PMC5347490_01
Chest CT scan revealed multiple tumors in bilateral lung: (a) pleural effusion, (b) swollen mediastinal lymph nodes, and (c) destructed thoracic vertebrae.
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Computed tomography (CT) and magnetic resonance imaging (MRI) findings revealed multiple bilateral lung nodules, swollen mediastinal lymph nodes, and osteolysis of thoracic vertebrae (Figure 1).
Histopathological finding of hematoxylin and eosin stained section: (a) pseudoalveolar arrangement of large and polygonal cells with abundant cytoplasm and (b) immunostain using anti-TFE3 antibody were positive for most of tumor cells.
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Histologically, the tumors showed a characteristic pseudoalveolar pattern, composed of large polygonal tumor cells with abundant cytoplasm, vesicular nuclei, marked nucleoli, and low nuclear cytoplasmic ratio (Figure 2(a)). The results were positive for TFE3 (Figure 2(b)) and S100 protein and very focally positive for CD10.