PMC10251436_01
Axial PET slices showing areas of moderate glucose hypometabolism in bilateral mesial brain regions in case 1 (A) and case 2 (B).
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F1
Visual analysis of PET images showed a moderate reduction in 18F-FDG uptake in the bilateral mesial-temporal region (Figure 1); these findings were confirmed by the voxel-wise analysis.
Coronal and axial slices showing SPM areas of reduced brain metabolism superimposed on a T1 axial magnetic resonance reference atlas. The colored areas indicate the locations where the voxel values of both patients are significantly hypometabolic compared to healthy subjects (P < 0.001). The t-values are represented by the brightness of the color.
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PMC10251436_01_fped-11-1165072-g002.jpg
F2
The SPM8 analysis showed, at a height threshold of p < 0.001 (uncorrected), a significant hypometabolism (p < 0.001) in both patients (n = 2), as compared to healthy subjects (n = 19), in the left and right mesial-temporal regions with a peak in the bilateral hippocampus (right: MNI coordinates 22/-12/-20 mm with a T-score of 6.7; left: MNI coordinates -20/-16/-19 mm with a T-score of 6.1; Figure 2).