PMC5480042_01
(a-c) The progression of invasive papillary breast carcinoma followed up for 10 years (LM, x200). ER: estrogen receptor; PR: progesterone receptor.
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fig1
In the past 10 years, the size of tumor increased to 12.1 x 9.0 x 4.2 cm and included multifocal air-bubble portions (Figure 1).
(a-c) Unaltered immunohistochemistry (ER/PR/C-erbB2/Ki-67) as an independent prognostic factor (LM, x200). H&E: hematoxylin and eosin; ER: estrogen receptor; PR: progesterone receptor.
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fig2
The immunohistochemistry results, corresponding to biopsies taken at subsequent examinations, have remained unaltered since 2006 (Figure 2).