PMC4211482_01
(A) A freckle and sable ulcer, measuring 2cmx1cm in diameter on the right nasal wall. (B) Histology showed nets of basaloid cells infiltrated in the dermis (x200). (C) The tumor was completely cleared at the 6-month follow-up visit. (D) After treatment, there are no tumor cells in this slide (x100).
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F1
The edge of the lesion has a characteristic rolled border, and hemorrhagic effusion on the surface of the ulcer (Figure 1A). A punch biopsy specimen of the lesion showed nets of basaloid cells infiltrated in the dermis characteristic of peripheral palisading and cleft, which is between tumor focal and matrix (Figure 1B). The ulcer was completely cleared after six months of treatment (Figure 1C). Skin biopsy revealed no tumor cells in the slide (Figure 1D).
PMC4211482_02
(A) An ulcer with blood crust, measuring 2.0cmx1.5 cm in diameter on the right temple. (B) Histology showed cystic spaces or necrosis in the centre of mass (x100). (C) The tumor was completely cleared at the 4-month follow-up visit. (D) Skin biopsy revealed infiltration of lymphocytes around the vessels in dermis, and no focal of tumor being seen (x100).
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F2
The lesion had a characteristic rolled border (Figure 2A). A punch biopsy specimen of the lesion showed cystic spaces or necrosis in the centre of mass (Figure 2B).The patient was initially treated with oral acitretin at a dose of 20 mg/d (0.4 mg/kg) and topical applied retinoc acid 0.1% cream two times daily. After 16 weeks, the lesion has disappeared (Figure 2C). Skin biopsy revealed infiltration of lymphocytes around the vessels in dermis and no focal of tumor was seen (Figure 2D).
PMC4211482_03
(A) Two tightening conjointed nodules on the left temple, measuring 2.0 cmx2.0cm and 1.0 cmx1.0cm in diameter, respectively. (B) A punch biopsy specimen of the lesion showed cystic spaces or necrosis in the centre of mass (x100). (C) The tumor was completely cleared at the 8-week follow-up visit. (D) Skin biopsy revealed infiltration of lymphocytes around the vessels indermis, and no focal of tumor cell being seen (x40).
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F3
The edge of the lesions had a characteristic rolled border (Figure 3A). A punch biopsy specimen of the lesions showed cystic spaces or necrosis in the center of mass (Figure 3B). The lesions were completely clear after eight weeks treatment (Figure 3C). Skin biopsy revealed infiltration of lymphocytes around the vessels in dermis and no focal of tumor cells was seen (Figure 3D).
PMC4211482_04
(A) A patch with blood crust, measuring 2cmx1.5cm in diameter on the right temple. (B) Histology showed large islands of tumor predominate (x100). (C) The tumor was completely cleared at the 8-week follow-up visit. (D) Skin biopsy revealed epidermis was infiltrated by lymphocytes (x100).
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F4
The edge of the lesion had swollen up with a characteristic rolled border (Figure 4A). A punch biopsy specimen of the lesion showed large islands of tumor predominate (Figure 4B). The tumor was completely clear at the 6-week follow-up visit (Figure 4C). Skin biopsy revealed epidermis infiltrated by lymphocytes (Figure 4D).