PMC6041115_01
Preoperative CT scans showing the mediastinal mass and the involvement of the sternum.
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Tomography (CT) scan was performed. This evaluation showed a retrosternal oval lesion (5.5 x 4 cm) with an intra- and extra-thoracic growth and a multifocal lymphadenopathy ranging between 7 mm and 4 cm in the prevascular area, aortopulmonary window, and right paratracheal station (Fig. 1).
Pathological images of the lesion: A) lymphoid nodule surrounded by fibrotic tissue (H&E, 20x), B) intralesional infiltrate composed of small lymphocytes, histiocytes, plasmacells, and numerous eosinophils (H&E, 200x), C) several mono- or plurinucleated lymphoid cells are evident, reminiscents of Reed-Sternberg cells, sometimes surrounded by a clear halo (H&E, 400x), D) these cells showed cytoplasmic (often membranous) positivity for CD30 (CD30, 600x).
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At immunohistochemistry these cells showed cytoplasmic (often membranous) positivity for CD30 (Fig. 2), and negativity for CLA, CK, CD79 and CD3.