PMC5024316_01
Average detection/stimulation counts (DSCs) by time of day (h). Blue, series one, refers to six-day average detection (January 1-6) on full-dose mirtazapine. Red, series two, refers to six-day average off of mirtazapine and trazodone (January 11-12 and 15-18; trazodone was taken on January 13-14 prior to bedtime). Green, series three, refers to six-day average back to full-dose mirtazapine (January 19-24).
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Her RNS system was interrogated; histograms of DSC by hour suggested far higher counts during sleeping hours than during wakeful hours while the patient was on mirtazapine (Fig. 1). Data appear in Fig. 1.