PMC7440724_01
PMC7440724_02
PMC7440724_03
PMC7440724_04
Corpus Callosum. The pseudocolored fibers are overlaid on each infant's own structural MPRAGE image. Five corpus callosum segments are of equal length where Green = genu; Light Blue = rostral body; Red = mid body; Dark Blue = isthmus/posterior body; Yellow = splenium. In the axial view right = right, left = left.
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There was visible improvement in the corpus callosum of Case 2 post-treatment which was comparable to Comparison 2 (Figure 1).
Corticospinal Tract (CST). The pseudocolored fibers are overlaid on each infant's own structural MPRAGE image.
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Case 1 pre- and post- cranial orthotic treatment CST reconstruction showed an intact tract when compared to the CST of the comparison infants (Figure 2). Case 2 pre- cranial orthotic treatment CST was thinner than the CST of Comparison 1, however, Case 2 post- cranial orthotic treatment CST was similar to the CST of Comparison 2.
Medial Lemniscus (ML). The pseudocolored fibers are overlaid on each infant's own structural MPRAGE image.
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However, Comparison 1 ML was thinner compared to the ML of the both Cases at pre cranial orthotic treatment time point (Figure 3).
Dorsal Language Network (DLN). The pseudocolored fibers are overlaid on each infant's own structural MPRAGE image. Green = anterior segment of the DLN; Red = long segment of the DLN; Yellow = posterior segment of the DLN. In the axial view right = right, left = left.
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Comparison 1 and Comparison 2 both had all 3 segments revealed bilaterally which all had a typical configuration (Figure 4).
Ventral Language Network (VLN). The pseudocolored fibers are overlaid on each infant's own structural MPRAGE image. Green = inferior longitudinal fasciculus (ILF); Red = inferior fronto-occipital fasciculus (IFOF); Yellow = uncinate fasciculus (UF). In the axial view right = right, left = left.
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Both Comparison 1 and Comparison 2 showed typical reconstruction of the VLN bilaterally (Figure 5).
Cingulum. The pseudocolored fibers are overlaid on each infant's own structural MPRAGE image. In the axial view right = right, left = left.
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Post-treatment of Case 2 showed clear improvement in the tracts of the whole cingulum bilaterally and was comparable to the cingulum of the Comparison 2 (Figure 6).