PMC7165335_01
An ulcerated mass in the anterior region of the mandible.
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The lesion was soft to firm in consistency on palpation (Figure 1).
The panoramic radiograph shows an ill-defined unilocular radiolucency extending from the right lateral incisor to the left second premolar, as well as root resorption of teeth 20, 21, and 22.
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Thinning and erosion of the lingual cortical plate and root resorption of teeth #22, #21, and #20 were also seen (Figures 2 and 3).
CBCT revealed a large destructive lesion with irregular borders associated with a soft tissue mass causing extensive perforation of the buccal cortical plate.
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Thinning and erosion of the lingual cortical plate and root resorption of teeth #22, #21, and #20 were also seen (Figures 2 and 3).
Microscopic sections showed papillary projections with fibrovascular cores lined by cuboidal and columnar cells (H & E x100).
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The nuclei showed a ground glass appearance (Figures 4 and 5).
The nuclei showed ground glass appearance (H & E x400).
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The nuclei showed a ground glass appearance (Figures 4 and 5).
The nuclei of neoplastic cells were strongly and diffusely positive for TTF1.
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The tumoral cells were strongly and diffusely positive for TTF1 and CK7 (Figures 6 and 7).
The cytoplasm of tumoral cells was strongly and diffusely positive for CK7 (x400).
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The tumoral cells were strongly and diffusely positive for TTF1 and CK7 (Figures 6 and 7).
Large hemorrhagic mandibular mass 10 days following initial visit.
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In addition, she had been suffering from bleeding of the lesion (Figure 8) and numb-chin syndrome.