PMC9935794_01
Radiographic images at first visit: (a) T2WI MRI image of the neck, (b) cervical X-ray, and (c) 99mTc-HMDP scintigraphy, ventral view (A) and dorsal view (B). Significant accumulation in the wrists, knees and sternoclavicular joints is shown.
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Before his visit to us, he was referred to our department of neurology for cervical chord lesions detected incidentally by MRI (Figure 1(a)). On the radiographic image, the third to fifth cervical bones were assimilated (Figure 1(b)) while an MRI of the sacroiliac (SI) joint was almost normal. 99mTc-HMDP bone scintigraphy showed accumulation in the wrists, knees, and sternoclavicular joints (Figure 1(c)).
Changes over time in BASDAI and CRP during the therapy with Brodalumab. At 0 weeks, subcutaneous injection of Brodalumab 210 mg was initiated (arrow) and repeated weekly for two weeks. After loading, it was maintained by injection every two weeks.
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BASDAI and CRP improved from 5.1 to 2.3 mg/dl before treatment to 1.3 and 0.2 mg/dl respectively at four weeks after treatment (Figure 2).