PMC9791267_01
H&E stains of the liver biopsy show malignant-appearing cells with a largely spindled morphology. The tumor cells show large nuclear/cytoplasmic ratios; large, extremely atypical nuclei with frequent prominent nucleoli; and coarse, clumped chromatin.. Abbreviation: H&E, hematoxylin and eosin.
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He underwent liver and portal lymph node core needle biopsies (Figure 1).
Bulky pretreatment tumor (top and bottom left) in liver with periportal adenopathy with obvious regression on posttreatment scans (top and bottom right).
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The patient is tolerating therapy and has completed 17/24 treatment cycles while remaining independent in his activities of daily living (Figure 2).