PMC8207277_01
Lymphocytoma cutis:firm, pink to red plaque on the left cheek, 5 x 6 cm in size.
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A 68-year-old woman presented with a pink to red plaque on the left cheek, 5 x 6 cm in size (Figure 1).
Lymphocytoma cutis treated with mycophenolate mofetil after 3 months (left) and 6 months (right).
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The MMF dose was increased to 1000 mg BID for 3 months with complete clearance (Figure 2).
(a) 2x magnification, dense nodular/follicular architecture extending into the mid/deep dermis, and the grenz zone; (b) 10x magnification, polarization of the follicles; (c) 20x magnification eosinophils in the bottom half (difficult to appreciate), tingible body macrophages.
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A skin biopsy of the left cheek showed a very dense nodular lymphocytic infiltrate with germinal centers containing tangible body macrophages (Figure 3).