PMC7337270_01
Histopathology of the biopsy specimen of the right cervical lymph node.. Monotonous infiltration of medium to large-sized lymphoma cells is observed
(A, low-power field; B, high-power field.
Hematoxylin-eosin staining). Immunohistochemistry shows that the lymphoma cells are
CD3-positive (C), CD20-negative (D) and CCR4-positive
(E).
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Biopsy specimens of cervical lymph nodes and abdominal skin exhibited monotonous infiltration of medium to large-sized lymphocytes with a phenotype of CD3+, CD5+, CD10-, CD20-, CD79a-, CD30-, CD56-, Bcl6-, granzyme B-, CD45RO-, CCR4+ and TdT-. (Figure 1A-E) The Ki-67 labeling index was 80%.
Thoracolumbar MR images: T2-weighted image (A) and
contrast-enhanced sagittal fat-saturated T1-weighted images
(B, C).. On the T2-weighted image, the CSF signal surrounding the conus medullaris is effaced.
Red triangles: The leptomeningeal linear or nodular enhancement,
corresponding to the intramedullary mass.
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On day 25, an intradural extramedullary mass was detected on thoracolumbar MRI, suggesting infiltrated lymphoma (Figure 2).