PMC7192399_01
Liver biopsy (A and B). A: H&E 20x, periductular clusters of malignant plasma cells with features of plasmablasts. In addition, increased iron deposits in hepatocytes and Kupffer Cells. B: kappa and lambda CISH 10x, plasma cells with monotypic kappa staining pattern.
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figure1
The biopsy demonstrated infiltration of bile ducts and ductules by clusters of atypical plasma cells with features of plasmablasts (Figure 1A and B).
Liver biopsy. (A and B). A: Trichrome stain 10x: the stain highlights the presence of fibrosis around the malignant plasma cells. B: Iron Stain 10x: increased intracytoplasmic iron deposits in hepatocytes and Kupffer Cells.
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figure2
A trichrome stain highlighted peri-cellular fibrosis around the infiltrate (Figure 2A). In addition, increased deposits of iron in the hepatocytes and Kupffer Cells were noted, consistent with secondary iron overload (Figures 2B).