PMC6280303_01
Haematoxylin and eosin stain at 400x magnification demonstrating numerous apoptotic bodies and patchy fibrotic changes in the perivenular and portal areas. This is consistent with generalized cholestatic and inflammatory changes.
CRIHEP2018-2816907.001.jpg
PMC6280303_01_CRIHEP2018-2816907.001.jpg
fig1
A core needle biopsy of the liver was performed, which revealed inflammatory activity and apoptotic bodies spanning all zones of the liver, in keeping with acute cholestatic hepatitis, a pathological picture often related to drug-induced liver injury or nonhepatic viral infection (Figures 1 and 2).
Periodic acid-Schiff stain at 100x magnification demonstrating decreased parenchymal glycogenation. PAS diastase reveals numerous Kupffer cells and portal macrophages.
CRIHEP2018-2816907.002.jpg
PMC6280303_01_CRIHEP2018-2816907.002.jpg
fig2
A core needle biopsy of the liver was performed, which revealed inflammatory activity and apoptotic bodies spanning all zones of the liver, in keeping with acute cholestatic hepatitis, a pathological picture often related to drug-induced liver injury or nonhepatic viral infection (Figures 1 and 2).