PMC5909731_01
Bony hard swelling causing obliteration of the vestibule of left side of mandible, extending from the right deciduous lateral incisor to the left deciduous second molar region
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The swelling caused buccal and lingual cortical expansion and the buccal plate was perforated in some areas (Fig. 1).
A) The CT revealed a well-defined multilocular radiolucent lesion extending from the lower right deciduous lateral incisor to the right deciduous second molar region. B) Bucco-lingual expansion, perforation and thinning of the buccal plate were observed. The lesion also showed small calcified areas. C) Multiple impacted permanent teeth were noted
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The lesion also showed small calcified areas and multiple impacted permanent teeth (Fig. 2).
A) Multiple follicles of proliferating odontogenic epithelium with the surrounding primitive ectomesenchyme showed increased cellularity simulating the dental papillae. B) Areas showing dentin formation and enamel spaces (hematoxylin-eosin, original magnification 100x).C, D) Areas with cartilage formation were also observed. These areas exhibited increased maturation as they progressed further away from the epithelial follicles, showing hypercellularity and some binucleated cells (hematoxylin-eosin, original magnification: C) 200x, D) 400x)
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The central cells were loosely arranged and angular to spindle in shape (Fig. 3A). The surrounding primitive ectomesenchyme showed increased cellularity simulating the dental papillae with areas showing dentin formation (Fig. 3B). The cartilaginous areas exhibited increased maturation as they progressed further away from the epithelial follicles (Fig. 3C, D).
A) Immunohistochemical examination revealed that all epithelial components showed strong diffuse reactivity for cytokeratin. B) The chondroid tissue also showed cytokeratin expression. C) Vimentin expression was detected in both the stromal ectomesenchymal component (D) and in the chondroid tissue (E & F) S-100 protein showed negative expression in all components (original magnification 200 x)
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Immunohistochemical examination revealed that all epithelial components showed strong diffuse reactivity for cytokeratin (Fig. 4A). The chondroid tissue also showed cytokeratin expression (Fig. 4B). Vimentin expression was detected in both the stromal ectomesenchymal component (Fig. 4C) and in the chondroid tissue (Fig. 4D). S-100 protein showed negative expression in all components (Fig. 4E, F).