PMC9149484_01
a Right fundus photograph - normal. b Left fundus photograph - subtle greyish lesion in the papillomacular region with accompanying epiretinal gliosis and loss of foveal reflex. Black arrows indicate retinal folds temporal to the lesion. a was taken with Zeiss Clarus  500, Jena, Germany. b was taken with Zeiss Visucam  224, Jena, Germany. This combination allowed for best resolution of available pictures.
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F1
Fundus examination of the right eye was normal (shown in Fig. 1a). Left eye fundus examination showed a subtle elevated greyish lesion in the papillomacular region with loss of the foveal reflex (shown in Fig. 1b). Accompanying epiretinal gliosis was also present (shown in Fig. 1b).
a Right macular OCT - normal. b Left macular OCT - inner retinal thickening with loss of foveal depression. The arrow indicates gliosis overlying the lesion.
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F2
Optical coherence tomography (OCT) of the right eye was normal (shown in Fig. 2a) whereas it revealed retinal thickening mostly of inner retinal layers in the left eye (shown in Fig. 2b). Retinal nerve fiber, ganglion cell, and inner plexiform layers were markedly thickened and showed an associated epilesional gliotic reaction (shown in Fig. 2b, green arrow).
a Right macular EDI-OCT - normal. b Left macular EDI-OCT - irregular retinal thickening associated with disorganization of inner and outer retinal layers. Choroidal thickness is 224 mum. Yellow arrow shows "shark-teeth" sign. Green arrow indicates marked thickening of outer nuclear layer.
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F3
Sub-foveal choroidal thickness measured by enhanced-depth imaging OCT was 283mum OD and 224mum OS (shown in Fig. 3a, b). The "shark-teeth" sign was present on OCT sections of the fovea (shown in Fig. 3b, yellow arrow). Marked thickening of the outer nuclear layer was also present on OCT sections near the fovea (shown in Fig. 3b, green arrow).
a Right macular near-infrared imaging - normal. b Left macular near-infrared imaging - generalized hyporeflectivity of the macular region with oblique linear hyperreflectivity corresponding to the epiretinal gliosis.
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F4
Near-infrared imaging of the right eye was normal (shown in Fig. 4a). Fig. 4b). Fundus and OCT findings were suggestive of a unilateral, solitary, foveal CHRRPE.