PMC9513261_01
Hypercellular bone marrow biopsy with increased myeloid/erythroid ratio.
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PMC9513261_01_gr1.jpg
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The bone marrow aspirate and biopsy showed hypercellular particles with increased amount of immature myeloid cells with relatively decreased erythroid precursors (Fig. 1).
(A) Fluorescence in situ hybridization was used for the detection of t(9;22)(q34;q11). (B) Cytogenetic analysis shows a complex variant three-way translocation 46,XX,t(9;22;16)(q34;q11.2;q24). Arrowheads designate all derivative chromosomes.
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Fluorescent in situ hybridization (FISH) results were positive for BCR::ABL1 fusion (Fig. 2), consistent with t(9;22) and negative for FIP1L1::PDGFRA fusion.