PMC8478362_01
PMC8478362_02
Skin bullae; A - bullae in the first patient; B - bulla with pooled blood in the second patient.
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Abdomen and lower limbs showed skin bullae, some of which with pooled blood (Figures 1 and 2).
A - histopathology from a bulla in the second case with epidermal delamination, without inflammatory changes (H&E, 2x); B - high power magnification from (A) showing subepidermal detachment with the accumulation of protein-rich fluid in the bullous cavity and dermal proliferation of rod-shaped bacteria without inflammatory reaction (H&E, 400x); C - rod-shaped bacteria in the dermis (H&E,1000x).
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Abdomen and lower limbs showed skin bullae, some of which with pooled blood (Figures 1 and 2).
Histopathology of the liver from the first case. A - multiple optically empty areas, with varying size (H&E, 2x); B - rod-shaped bacteria in adjacent liver parenchyma without inflammatory reaction (H&E, 400x); C - rod-shaped bacteria in the liver parenchyma (H&E,1000x).
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In both patients, the most severely affected organ was the steatotic liver (Figures 3, 4).
Histopathology of the liver from the second case. A - multiple large optically empty areas (H&E, 2x); B - rod-shaped bacteria in adjacent liver parenchyma without inflammatory reaction (H&E, 400x).
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In both patients, the most severely affected organ was the steatotic liver (Figures 3, 4).
Histopathology of the spleen from the first case. A - multiple large optically empty areas (H&E, 2x); B - rod-shaped bacteria in adjacent parenchyma and bacterial colonies without inflammatory reaction (H&E 400x); C - rod-shaped bacteria in spleen parenchyma (H&E,1000x).
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Histopathology of the myocardium from the second case. A - multiple optically empty areas, with varying size (H&E, 2x); B - rod-shaped bacteria in adjacent parenchyma without inflammatory reaction (H&E 400x); C - rod-shaped bacteria in the myocardium, H&E 1000x).
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