PMC5019129_01
H&E images of breast tumor and bone metastasis. (A) Shows well-differentiated to moderately differentiated invasive ductal breast carcinoma in the right breast. (B-C) Shows metastasis with well-differentiated features of invasive ductal breast carcinoma isolated from the hip (B) and femur (C) resection from the same patient. Scale bar represents 100 mum.
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Representative images of the IDC in both the right breast and right hip are shown in Figure 1A and B. Histology of the femur revealed metastatic IDC (Fig. 1C).
Weight versus time (months after diagnosis) and surgical, pharmacological, and clinical events. An initial decrease in weight corresponds with the initiation of surgical and medical interventions; later a decline in weight around 18 months after the time of diagnosis in August 2013 corresponds with the timing of several interventions and clinical events. Lettered items below the axis in dark blue correspond to surgical events as follows: A) bilateral salpingo-oophorectomy, B) spinal fusion, C) right total hip replacement, D) left total hip replacement, and E) wound spinal revision. Lettered items below the axis in bright blue correspond to clinical events as follows: F) start letrozole, G) start Arixta, and H) stop letrozole. Lettered items below the axis in pale blue correspond to clinical events as follows: I) left deep vein thrombosis, J) left femur and left hip metastasis, and K) right hip, right femur metastasis, and T11 metastasis.
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Her weight loss over time could have been affected by clinical events, medical intervention, or surgical intervention (Fig. 2).