PMC6332779_01
Family pedigree. Note inbreeding meeting in the family because both monozygotic twin sisters had the same couple. In individuals III-1, IV-1, IV-2, IV-3 and IV-4 their human leukocyte antigen (HLA) haplotype is shown on their right side. Interesting, purpose and daughter IV-4, as well as both brothers share the same HLA haplotype, respectively. The rest affected individuals were diagnosed with some endocrinopathy but were not reviewed by us and did not accept the HLA test
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PMC6332779_01_CCR3-7-79-g001.jpg
ccr31919-fig-0001
We investigated the genes of the human leukocyte antigen (HLA) class I system (HLA-A, HLA-B, HLA-C) and class II (HLA-DR, HLA-DQ) to examine the genetic basis of autoimmunity in this family, and Figure 1 shows the results.