PMC8244589_01
Light microscopy. Early stage of thrombotic microangiopathy: this artery shows oedematous intima and few myointimal cells corresponding to "mucoid intimal hyperplasia" (FAOG, 400x).
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F1
Kidney biopsy showed diffuse glomerular sclerosis (90%), interstitial fibrosis (90%) and tubular atrophy, associated with severe vascular lesions characteristic of TMA (Figures 1, 2).
Light microscopy. Later changes of thrombotic microangiopathy: the artery contains fibro-oedema with few collagen fibers within intima revealed in blue with trichome FAOG (FAOG, 400x).
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F2
Kidney biopsy showed diffuse glomerular sclerosis (90%), interstitial fibrosis (90%) and tubular atrophy, associated with severe vascular lesions characteristic of TMA (Figures 1, 2).
Immunofluorescence microscopy. IgA deposits are observed within mesangium and glomerular membranes (400x).
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F3
IgA (Figure 3) and C3 deposits, with focal IgA staining in some arterioles. In addition, deposits of C5b-9, were present with IgA and C3 deposits, within the mesangium and the wall of small arterioles.