PMC7048152_01
Hypopigmented patches on the patient's back.
dic-8-212582-g001.jpg
PMC7048152_01_dic-8-212582-g001.jpg
f1-dic-212582_brugnara
In February 2017, a dermatologic clinical examination found several hypopigmented patches on the patient's forehead and back, suggesting vitiligo (Figure 1).
The absence of melanocytes and pigment in the epidermis was shown in hematoxylin and eosin stained slices.
dic-8-212582-g002.jpg
PMC7048152_01_dic-8-212582-g002.jpg
f2-dic-212582_brugnara
The CD3+CD4+/CD3+CD8+ ratio was 3.3 (normal value 1-2.5), with prevalent Th lymphocytes (Figures 2 and 3).
Immunohistochemical staining with Melan A showed the absence of melanocytes in the epidermis, confirming the diagnosis of vitiligo.
dic-8-212582-g003.jpg
PMC7048152_01_dic-8-212582-g003.jpg
f3-dic-212582_brugnara
The CD3+CD4+/CD3+CD8+ ratio was 3.3 (normal value 1-2.5), with prevalent Th lymphocytes (Figures 2 and 3).