PMC9720555_01
Imaging findings. (A) Enhanced computed tomography shows a well-defined tumor with heterogeneous hyperattenuation in the small intestine (yellow arrow). (B) Double-balloon endoscopy shows a submucosal tumor in the ileum. (C) An ileal series on double-balloon endoscopy shows a filling defect corresponding to the tumor site (yellow arrow). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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Computed tomography (CT) revealed a well-circumscribed tumor with heterogeneous hyperattenuation in the small intestine (Fig. 1A). Double-balloon endoscopy (DBE) revealed a submucosal tumor (SMT) in the ileum (Fig. 1B), and the ileal series showed filling defects corresponding to the tumor site (Fig. 1C).
Intraoperative findings reveal redness on the serosa of the ileum 90 cm from the ileocecal valve (white arrow), consistent with the tumor.
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Intraoperative findings revealed erythema of the serosa of the ileum 90 cm from the ileocecal valve (Fig. 2).
Macroscopic findings identified a round 15-mm submucosal tumor (yellow arrow). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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The macroscopic results showed a round 15-mm SMT (Fig. 3), and the histopathological examination revealed spindle-shaped cell growth and peritumoral lymphoid cuffs (Fig. 4A-C).
Histopathological and immunohistochemical findings. (A) The histopathological findings revealed a well-defined submucosal tumor; hematoxylin and eosin staining (6x). (B, C) The tumor had a peritumoral lymphoid cuff, characteristic of intestinal schwannoma (yellow arrow), and spindle-shaped cell growth; hematoxylin and eosin staining: (B) 40x and (C) 200x. Immunohistochemical analysis revealed tumor cells with negative staining for (D) c-kit and (E) CD34, but positive staining for (F) S100 (all 40x). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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Immunohistochemical analysis demonstrated that the tumor cells were negative for c-kit and CD34 but positive for S100 staining (Fig. 4D-F); therefore, the patient was diagnosed with ileal schwannoma.