PMC7184790_01
Spindle squamous cell carcinoma prior to excision.
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F1
At the time of excision, the tumor had grown to 3 x 3.5 cm (Fig. 1).
Hematoxylin-eosin stain of section from completely excised skin tumor located on the right gluteal region. Short black arrow: epidermis with hyperplasia. White arrow: poorly differentiated squamous cell carcinoma in upper dermis. Long black arrow: spindle cell carcinoma in dermis
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F2
The histology following the complete resection of the tumor showed a central area with papillomatosis and partly ulcerated surface, and transition from hyperplastic and dysplastic squamous epithelium to invasive low-differentiated SCC with a dominating spindle cell component (Fig. 2).
Hematoxylin-eosin stain of section of lymph node from right inguinal region (x10). Black arrow: lymphatic tissue. Blue arrow: metastatic spindle cell carcinoma. Lower right corner: metastatic spindle cell carcinoma, immunohistochemical positive reaction cytokeratin 14, confirming epithelial origin.
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F3
Immunohistochemically, a positive reaction for cytokeratin CK14 and P40 was observed as well as co-expression of vimentin (Fig. 3).