PMC4408676_01
(a) Ovoid to spindly tumoral cells are embedded in chondromyxoid tissue fragments. (b) Highly pleomorphic small epithelial islands adjacentt to the chondromixoid tissue fragments. (c) Some chondrocyte like cells are observed in abundant metachromatic extracellular material. d)Tumor cells admixed with necrotic material
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F1
These cells also formed sheet-like clusters [Figure 1a]. Between these neoplastic tissue fragments, loosely cohesive, highly pleomorphic epithelial cells with hyperchromatic and angulated nuclei were present [Figure 1b]. Some chondrocyte like cells were found to be present in the metachromatic extracellular matrix [Figure 1c]. One of the aspirates was mostly composed of necrosis [Figure 1d].
(a and b) Transition from carcinoma to chondromyxoid matrix without intervening spindle cell component. (c) High grade hyaline cartilaginous matrix. (d) Central comedo-necrosis with high grade solid undifferentiated mammary carcinoma
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F2
Histopathological examination showed invasive carcinoma with an abrupt transition to chondromyxoid matrix without an intervening spindle cell component [Figure 2a and b]. Medium to large sized chondrocyte-like tumor cells embedded in a chondromyxoid matrix sometimes formed discrete nodules [Figure 2a]. Focal areas of the matrix ranged from mucoid appearing to hyaline cartilaginous matrix [Figure 2c]. The chondromyxoid matrix was multifocal and mostly of high grade and showed direct transition to a carcinomatous component, which was composed of high grade undifferentiated mammary carcinoma with necrotic areas [Figure 2d].