PMC5824516_01
H & E stain of 10X view showing tumour cells arranged in alveolar pattern separated by fibrovascular stroma
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F1
On microscopic examination, the tumor was composed of cells arranged in alveolar pattern separated by fibrovascular stroma [Figure 1].
H & E stain 40x view showing Two distinctive types of cells - large cells arranged peripherally with abundant cytoplasm, round vesicular nucleus and brown pigment; and small cells with scanty cytoplasm and hyperchromatic round nuclei were seen in the center
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F2
Two distinctive types of cells were seen - large cells arranged peripherally with abundant cytoplasm, round vesicular nucleus and brown pigment; and small cells with scanty cytoplasm and hyperchromatic round nuclei were seen in the center [Figure 2].
IHC Stain Cytokeratin
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F3
Cytokeratin, [Figure 3] MELAN-A and HMB45 [Figure 4] were positive in large cells and negative for small cells.
IHC stain HMB45
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F4
Cytokeratin, [Figure 3] MELAN-A and HMB45 [Figure 4] were positive in large cells and negative for small cells.
IHC Stain NSE
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F5
Neuron-specific enolase (NSE) [Figure 5] and synaptophysin [Figure 6] were positive in small round cells and negative in large cells.
IHC Stain Synaptophysin
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F6
Neuron-specific enolase (NSE) [Figure 5] and synaptophysin [Figure 6] were positive in small round cells and negative in large cells.