PMC4004835_01
Growth chart. The patient's height and weight were almost the mean until the age of
11. His growth spurt started at about the age of 13 and his adolescence was of the
slightly delayed type.
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Both growth and development were normal with therapy (Fig. 1). At the age of 15, his height was 167 cm, and his weight was 57 kg (Fig. 1).
Clinical course until the age of 13. The dosage of thyroid hormone was gradually
increased as he grew and the maximum dose was 110 mug/day. Serum
levels of TSH were within the normal range. At the age of 13 yr and 4 mo, the serum
level of TSH dropped to an undetectable level.
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The dosage of l-thyroxine was gradually increased as he grew and the maximum dose was 110 mug/day at the age of 11 (Fig. 2).
Clinical course after the age of 13. The initial dosage of methimazole (MMI) was 20
mg/day. One month after the start of therapy, the serum level of free T4
was normalized. After two months of therapy, the serum level of TSH had risen to a
detectable level.
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Having confirmed hyperthyroidism, therapy was started with antithyroid drugs (Fig. 3).