PMC2868923_01
Brain magnetic resonance images of the patient at age 72 years showing slightly enlarged biparietal sulci and the absence of frontal or temporal lobar atrophy.
nihms197959f1.jpg
PMC2868923_01_nihms197959f1.jpg
F1
Retrospective review of these images suggested bilateral parietal atrophy (Figure 1).
Positron emission tomography with radiolabeled fluorodeoxyglucose in the patient at age 73 years showing hypometabolism in the bilateral parietal and anterotemporal regions.
nihms197959f2.jpg
PMC2868923_01_nihms197959f2.jpg
F2
Positron emission tomography (PET) demonstrated hypometabolism in the bilateral parietal and anterotemporal regions (Figure 2). There were neuritic plaques in the lateral, laterobasal, and accessory basal amygdala ranging from approximately 10 to 20 per 1.6 mm2 (Figure 5); 2+ Kromer Vogt rating for plaques in the amygdala.
Bielschowsky silver impregnation staining showing an overview of large neuritic plaques (arrows) and smaller neurofibrillary tangles in the lateral amygdala adjacent to the inferior horn of the lateral ventricle. Bar=0.5 mm.
nihms197959f3.jpg
PMC2868923_01_nihms197959f3.jpg
F3
Neurofibrillary tangles were abundant in the lateral amygdala (approximately 150 per 1.6 mm2) (Figure 3 and Figure 4).
Bielschowsky silver impregnation staining showing a higher-power view of neurofibrillary tangles (arrowheads) in the lateral amygdala (approximately 150 tangles per 1.6 mm2). Bar=0.1 mm.
nihms197959f4.jpg
PMC2868923_01_nihms197959f4.jpg
F4
Neurofibrillary tangles were abundant in the lateral amygdala (approximately 150 per 1.6 mm2) (Figure 3 and Figure 4).
Bielschowsky silver impregnation staining showing a higher-power view of neuritic plaques, amyloid core, and surrounding tangles (approximately 10-20 neuritic plaques per 1.6 mm2). Bar=0.1 mm.
nihms197959f5.jpg
PMC2868923_01_nihms197959f5.jpg
F5
There were neuritic plaques in the lateral, laterobasal, and accessory basal amygdala ranging from approximately 10 to 20 per 1.6 mm2 (Figure 5); 2+ Kromer Vogt rating for plaques in the amygdala.