PMC3615912_01
Right conjunctival amyloidosis.
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Progressive swelling decreased visual acuity and then development of ptosis during the last 8 months, prompted the patient to seek ophthalmologic evaluation (Figure 1).
Histological section of conjunctiva showing stromal nodular accumulation of proteinaceous acellular material with minimal associated perivascular plasma cells and lymphocytes. (hematoxylin and eosin, x400).
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Histopathological examination demonstrated amyloid deposition within the conjunctival stroma and subconjunctival fibro-adipose tissue (Figure 2), highlighted by Congo red histochemical stain with birefringence and apple-green dichroism of extracellular deposits under polarized light (Figure 3A,B).Both kappa and lambda light chains were detected on immunohistochemical, immunofluorescence, and in-situ hybridization studies.
Characteristic dichroism of amyloid on polarized light examination. (A) Congo red, x200; (B) Congo red (polarized), x200).
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Histopathological examination demonstrated amyloid deposition within the conjunctival stroma and subconjunctival fibro-adipose tissue (Figure 2), highlighted by Congo red histochemical stain with birefringence and apple-green dichroism of extracellular deposits under polarized light (Figure 3A,B).Both kappa and lambda light chains were detected on immunohistochemical, immunofluorescence, and in-situ hybridization studies.