PMC1796851_01
MRI scan showing a large bifrontal hyperintense mass with central necrosis.
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F1
T1-weighted image, occupying the anterior cranial compartment [Fig 1]. The tumor was compressing the frontal horns of lateral ventricles along with anterior part of corpus callosum.
Cut-section of the tumor showing grayish-white irregular and friable surface.
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F2
Gross examination of the resected tumor showed a 10 x 8 x 2 cm soft tissue with its cut-section showing grayish-white, irregular surface with focal necrosis [Fig 2].
Photomicrograph of the tumor showing sheets of tumor cells arranged in papillary pattern and a papilla with fibrovascular core (inset) (H&E, x200).
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F3
Histopathological examination revealed a tumor tissue composed of sheets of cells arranged in perivascular pseudopapillary pattern [Fig 3] along with few well formed papillae with central fibrovascular core [Fig 3, inset].
Tumor cells showing immunoreactivity to (a) MIB-1 and (b) EMA (x400).
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F4
MIB-1 labeling index was high with mean LI of 12% [Fig 4a]. Immunohistochemical positivity to epithelial membrane antigen (EMA) [Fig 4b] and vimentin was seen while Cytokeratin (CK), GFAP and S100 were non-reactive.