PMC6628912_01
Day of presentation: many circular pink edematous papules and small plaques with dusky violaceous centers
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F1
Skin examination revealed pink, annular, edematous papules and plaques on the face, trunk, buttocks, and extremities, many with dusky, violaceous centers (Figure 1).
Skin biopsy pathology revealed necrotic keratinocytes within the epidermis and an interface dermatitis consistent with the erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrosis spectrum of inflammatory dermatoses
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F2
Skin biopsy (Figure 2) revealed necrotic keratinocytes within the epidermis and an interface dermatitis consistent with the erythema multiforme/Stevens-Johnson syndrome (EM/SJS) spectrum of inflammatory dermatoses.
Day 2 of hospital course: rapidly progressing rash with more than 10% skin fragility and denudation
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F3
Despite supportive therapy, the patient's eruption rapidly progressed to involve more than 10% of his body surface area, with skin fragility and denudation (Figure 3), requiring transfer to intensive care.