PMC10369183_01
Brain MRI characteristic of SPATCCM in the proband (top panel) and his affected brother (lower panel). (A) Sagittal T1 weighted image demonstrates significant thinning of the corpus callosum. (B) Axial T2-Weighted Image demonstrating atrophy of the frontal and temporal lobes with a prominence of the subarachnoid spaces. (C) Widening of the Sylvian fissures. (D) Sagittal T1-weighted image demonstrates significant thinning of the corpus callosum and mild atrophy of the cerebellum. (E) Axial T2-Weighted Image demonstrating generalized atrophy of the frontal, temporal, and parietal lobes with a prominence of the subarachnoid spaces; enlargement of the ventricular system is not compatible with the chronological age of the patient. (F) Widening of the Sylvian fissures.
fped-11-1183574-g002.jpg
PMC10369183_03_fped-11-1183574-g002.jpg
F2
Like his sibling but to a lesser extent, Brain MRI showed atrophy of the frontal and temporal lobes with a prominence of the subarachnoid spaces and widening of the Sylvian fissures bilaterally associated with thinning of the corpus callosum (Figures 2D-F).
PMC10369183_02
PMC10369183_03
Brain MRI characteristic of SPATCCM in the proband (top panel) and his affected brother (lower panel). (A) Sagittal T1 weighted image demonstrates significant thinning of the corpus callosum. (B) Axial T2-Weighted Image demonstrating atrophy of the frontal and temporal lobes with a prominence of the subarachnoid spaces. (C) Widening of the Sylvian fissures. (D) Sagittal T1-weighted image demonstrates significant thinning of the corpus callosum and mild atrophy of the cerebellum. (E) Axial T2-Weighted Image demonstrating generalized atrophy of the frontal, temporal, and parietal lobes with a prominence of the subarachnoid spaces; enlargement of the ventricular system is not compatible with the chronological age of the patient. (F) Widening of the Sylvian fissures.
fped-11-1183574-g002.jpg
PMC10369183_03_fped-11-1183574-g002.jpg
F2
Like his sibling but to a lesser extent, Brain MRI showed atrophy of the frontal and temporal lobes with a prominence of the subarachnoid spaces and widening of the Sylvian fissures bilaterally associated with thinning of the corpus callosum (Figures 2D-F).