PMC5436009_01
Multiple pigmented follicular papules (a) and widespread ulcers on the right lower leg (b). c, d Dense infiltrate of atypical lymphocytes throughout the dermis with Langhans giant cells and epithelioid cells. Original magnification x100 (c) and x400 (d).
cro-0010-0372-g01.jpg
PMC5436009_01_cro-0010-0372-g01.jpg
f1
On her initial visit, physical examination revealed multiple pigmented follicular papules (Fig. 1a) and widespread ulcers on the right lower leg (Fig. 1b). Histological findings revealed dense infiltrate of atypical lymphocytes throughout the dermis with Langhans type giant cells and epithelioid cells (Fig. 1c, d).
Paraffin-embedded tissue samples were deparaffinized and stained with anti-CD30 Ab (a) and anti-CD163 Ab (b). The sections were developed with 3,3'-diaminobenzidine tetrahydrochloride (a) or liquid permanent red (b). c Biopsy from the left inguinal lymph node revealed prominent masses of epithelioid cells with giant cells and a dense infiltrate of atypical lymphocytes. Original magnification x200 (a, b) and x100 (c).
cro-0010-0372-g02.jpg
PMC5436009_01_cro-0010-0372-g02.jpg
f2
In addition, a dense infiltration of CD30+ cells (Fig. 2a) and CD163+ macrophages (Fig. 2b), both of which possessed dendritic-shaped cytoplasm, was observed. The lymph node biopsy from the left inguinal lymph node revealed prominent masses of epithelioid cells with giant cells and a dense infiltrate of atypical lymphocytes (Fig. 2c).