PMC6129762_01
PMC6129762_02
MR T1 images in the coronal plane for LS (left column) and AS's baseline (middle column) and repeat (right column) examinations.
fpsyg-09-01615-g002.jpg
PMC6129762_03_fpsyg-09-01615-g002.jpg
F2
Brain MRI revealed cerebral atrophy involving the superior frontal, temporal, and parietal regions bilaterally (Figure 2). On brain MRI, diffuse additional atrophy was observed, compared to the baseline examination (Figure 2).
PMC6129762_03
Pedigree of the S family. The two cases reported here are indicated by the arrows. Crossed symbols indicate deceased individuals with age of death noted below. Black symbols represent diagnosis of frontotemporal dementia (FTD). Grey symbols represent diagnosis of motor neuron disease (MND). Note that Cases II:2 and IV:1 received a dual diagnosis of FTD and MND.
fpsyg-09-01615-g001.jpg
PMC6129762_03_fpsyg-09-01615-g001.jpg
F1
AS, second degree relative of LS (Figure 1) with 15 years of formal education, presented in their early 80s, 5 years after the onset of cognitive and behavioural symptoms.
MR T1 images in the coronal plane for LS (left column) and AS's baseline (middle column) and repeat (right column) examinations.
fpsyg-09-01615-g002.jpg
PMC6129762_03_fpsyg-09-01615-g002.jpg
F2
Brain MRI revealed cerebral atrophy involving the superior frontal, temporal, and parietal regions bilaterally (Figure 2). On brain MRI, diffuse additional atrophy was observed, compared to the baseline examination (Figure 2).