PMC10362653_01
PMC10362653_02
A) X-ray of the left thigh showing an oval opacity in the soft parts located in the inner face of the mid-thigh; B) chest X-ray showing pulmonary nodules of metastatic appearance
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F1
The Chest X-ray revealed the presence of pulmonary nodules of metastatic appearance (Figure 1).
MRI of the thigh showing a well limited soft tissue mass, roughly rounded, with polylobed contours, measuring 8cm in great axis, pushing the medial rectus muscle, respecting the femur and the vascular-nervous bundle
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F2
The MRI revealed a well limited soft tissue mass, roughly rounded, with polylobed contours, in T1 hypo signal and T2 heterogeneous hyper signal, measuring 8cm in great axis, pushing the medial rectus muscle, respecting the femur and the vascular-nervous bundle (Figure 2).
macroscopic appearance of the tumor, showing a soft tissue encapsulated mass with polylobed contours, displaying multiple lobules of gelatinous appearance, separated by fibrous septa with prominent hemorrhage and necrosis
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F3
The gross examination of the resection specimen revealed an encapsulated mass with polylobed contour, measuring 8x7cm, displaying at cut multiple lobules of translucent gelatinous appearance, separated by fibrous septa, with prominent hemorrhage and necrosis (Figure 3).
A) low power view showing a soft tissue tumoral proliferation, well limited at periphery by a fibrous capsule; B) multinodular growth pattern with delicate fibrous septas (Hematoxylin and eosin staining, magnification x4)
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F4
The histological findings in the biopsy and the resection specimen were identical, revealing a tumoral proliferation well limited by a fibrous capsule at periphery, showing a multinodular growth pattern, made of strands and cords of bland looking cells, embedded within copious myxoid matrix (Figure 4).
A) low magnification view showing a striking myxoid background with prominent intra-tumoral hemorrhage (Magnification x4); B) strands and cords of interconnected tumor cells embedded within the myxoid matrix, with focal hemosiderin deposition (magnification x10)
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F5
The stroma is densely myxoid and hypo vascular, with prominent hemorrhage and focal hemosiderin deposition (Figure 5).
uniform tumor cells provided with bland ovoid nuclei and interconnected by delicate cytoplasmic processes (magnification x40)
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F6
The tumor cells are provided with small ovoid nuclei, and acidophilic cytoplasm, occasionally vacuolated, emitting cytoplasmic projections interconnecting the cells (Figure 6).
tumors cells showing diffuse expression of GFAP and NSE while EMA and cytokeratin were expressed focally
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F7
While Epithelial membrane antigen (EMA) and Cytokeratin were expressed focally (Figure 7).