PMC8281927_01
The CT images of the adrenal glands for case1 (A), case 2 (B) and case 3 (C). Adrenal contrast-enhanced CT showed adrenal hyperplasia (arrows).
fendo-12-687809-g001.jpg
PMC8281927_03_fendo-12-687809-g001.jpg
f1
MRI of the pituitary gland did not showed signs of pituitary adenoma ( Supplementary Figure 1C ). Abdominal CT only showed nodular hyperplasia of the left adrenal gland ( Figure 1C ).
Low power views showing the thickened medulla (black triangle) and hyperplastic adrenal cortex (black star) (A). High-power views of the medulla (B). Chromogranin expression in the medullary cells (C). High-power views of the cortex (D).
fendo-12-687809-g002.jpg
PMC8281927_03_fendo-12-687809-g002.jpg
f2
ACTH staining in hyperplastic adrenal medulla cells ( Figures 2A-C ,  3C ) and nodular hyperplasia of adrenal cortex in both adrenal glands ( Figure 2D ).
ACTH immunostaining of the adrenal glands for case1 (A), case 2 (B), case 3 (C), adrenal cortex of normal control (D) and adrenal medulla of normal control (E). ACTH staining showed sporadic positive ACTH staining for case 1, numerous adrenal medulla cells positive for ACTH for case 2, focal positive ACTH staining for case 3 and negative ACTH staining for normal control.
fendo-12-687809-g003.jpg
PMC8281927_03_fendo-12-687809-g003.jpg
f3
ACTH staining in hyperplastic adrenal medulla cells ( Figures 2A-C ,  3C ) and nodular hyperplasia of adrenal cortex in both adrenal glands ( Figure 2D ).
PMC8281927_02
The CT images of the adrenal glands for case1 (A), case 2 (B) and case 3 (C). Adrenal contrast-enhanced CT showed adrenal hyperplasia (arrows).
fendo-12-687809-g001.jpg
PMC8281927_03_fendo-12-687809-g001.jpg
f1
MRI of the pituitary gland did not showed signs of pituitary adenoma ( Supplementary Figure 1C ). Abdominal CT only showed nodular hyperplasia of the left adrenal gland ( Figure 1C ).
Low power views showing the thickened medulla (black triangle) and hyperplastic adrenal cortex (black star) (A). High-power views of the medulla (B). Chromogranin expression in the medullary cells (C). High-power views of the cortex (D).
fendo-12-687809-g002.jpg
PMC8281927_03_fendo-12-687809-g002.jpg
f2
ACTH staining in hyperplastic adrenal medulla cells ( Figures 2A-C ,  3C ) and nodular hyperplasia of adrenal cortex in both adrenal glands ( Figure 2D ).
ACTH immunostaining of the adrenal glands for case1 (A), case 2 (B), case 3 (C), adrenal cortex of normal control (D) and adrenal medulla of normal control (E). ACTH staining showed sporadic positive ACTH staining for case 1, numerous adrenal medulla cells positive for ACTH for case 2, focal positive ACTH staining for case 3 and negative ACTH staining for normal control.
fendo-12-687809-g003.jpg
PMC8281927_03_fendo-12-687809-g003.jpg
f3
ACTH staining in hyperplastic adrenal medulla cells ( Figures 2A-C ,  3C ) and nodular hyperplasia of adrenal cortex in both adrenal glands ( Figure 2D ).
PMC8281927_03
The CT images of the adrenal glands for case1 (A), case 2 (B) and case 3 (C). Adrenal contrast-enhanced CT showed adrenal hyperplasia (arrows).
fendo-12-687809-g001.jpg
PMC8281927_03_fendo-12-687809-g001.jpg
f1
MRI of the pituitary gland did not showed signs of pituitary adenoma ( Supplementary Figure 1C ). Abdominal CT only showed nodular hyperplasia of the left adrenal gland ( Figure 1C ).
Low power views showing the thickened medulla (black triangle) and hyperplastic adrenal cortex (black star) (A). High-power views of the medulla (B). Chromogranin expression in the medullary cells (C). High-power views of the cortex (D).
fendo-12-687809-g002.jpg
PMC8281927_03_fendo-12-687809-g002.jpg
f2
ACTH staining in hyperplastic adrenal medulla cells ( Figures 2A-C ,  3C ) and nodular hyperplasia of adrenal cortex in both adrenal glands ( Figure 2D ).
ACTH immunostaining of the adrenal glands for case1 (A), case 2 (B), case 3 (C), adrenal cortex of normal control (D) and adrenal medulla of normal control (E). ACTH staining showed sporadic positive ACTH staining for case 1, numerous adrenal medulla cells positive for ACTH for case 2, focal positive ACTH staining for case 3 and negative ACTH staining for normal control.
fendo-12-687809-g003.jpg
PMC8281927_03_fendo-12-687809-g003.jpg
f3
ACTH staining in hyperplastic adrenal medulla cells ( Figures 2A-C ,  3C ) and nodular hyperplasia of adrenal cortex in both adrenal glands ( Figure 2D ).