PMC8794452_01
Histological examination of first bone marrow aspiration, showing pure red cell aplasia (hematoxylin and eosin stain, 10x).
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The exam showed a serious depletion of erythroblasts, confirming the hypothesis of the condition of PRCA, likely related to thymoma (Figures 1,2).
Histological examination of second bone marrow aspiration, showing red cell aplasia and depletion of megakaryocytes (hematoxylin and eosin stain, 10x).
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During hospitalization, multiple red cells and platelets transfusions were necessary and a second BMA was conducted, showing a condition of medullary aplasia of both erythrocyte and megakaryocytic lines (cellularity of 30%, myeloid blasts <1%, 5% mitosis) (Figures 3,4).