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Biopsy of pedunculated perianal lesion from patient 1. The biopsy shows a pedunculated condyloma with a transition zone to SCCIS (Hematoxylin-eosin stain; original magnification: x40.)
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The biopsy found a pedunculated condyloma with a transition zone to squamous cell carcinoma in situ (Fig 1) with HPV-16 positivity (Fig 2).
HPV-16 immunostaining of the lesion in Fig 1. Significant HPV-16 nuclear staining is observed within the pedunculated lesion excised from patient 1. HPV-16 staining can be seen within the SCCIS region of the specimen (arrow 1) and within the adjacent condyloma (arrow 2) (original magnification: x40.)
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The biopsy found a pedunculated condyloma with a transition zone to squamous cell carcinoma in situ (Fig 1) with HPV-16 positivity (Fig 2).
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HPV-related oral leukoplakia with biopsy-proven invasive squamous cell carcinoma. This is the clinical appearance before Mohs surgery (A) and after clearance of the tumor (B).
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A man in his 40s with a long history of HIV positivity, moderate-to-heavy smoking, disseminated Kaposi's sarcoma, HPV-related oral leukoplakia (and subsequent invasive squamous cell carcinoma; Fig 3), HPV-related rectal cancer in remission, and a CD4 count less than 200 cells per microliter presented for evaluation and treatment of condylomata on the penis and perianal region.
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