PMC9747738_01
a PET-CT reveals intense FDG uptake in the bone marrow, and an increased uptake, but to a lesser extent, in the liver. The spleen did not exhibit FDG uptake. PET-CT can be a valuable tool to exclude secondary causes of HLH and identify sites of hemophagocytosis. b Bone marrow aspirates demonstrating evidence of hemophagocytosis (x400).
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F1
Upon 18F-fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET)-CT, liver uptake was relatively even (standardized uptake value max/mean, 3.2/2.3), and FDG activity was not increased in the spleen (shown in Fig. 1a). A bone marrow biopsy revealed normocellular marrow with substantial histiocytosis and active hemophagocytosis, without any malignant cell infiltration (shown in Fig. 1b).