PMC6381419_01
Color fundus photography (initial manifestation): radiation maculopathy with enlarged arterial calibration, intraretinal hemorrhages, exudates, microaneurisms, and diffuse macular edema (A, B). Fundus fluorescein angiography (late venous phase): bilateral enlarged and clear-cut foveal avascular zone with perifoveal teleangiectasia and diffuse macular edema (C, D)
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F1
The left retina showed modest intraretinal hemorrhages and microaneurisms at the posterior pole and enlarged arterial calibration (Figure 1 A, B (Fig. 1)). Diffuse macular leakage was observed in the late venous phase bilaterally (Figure 1 C, D (Fig. 1)). 
Color fundus photography (Eleven years after initial presentation): retinal crystals surrounding the fovea bilaterally (A, B). Optical coherence tomography (single horizontal linear scan): punctate hyperreflectivity in near all retinal layers. Retinal crystals are corresponding to superficial hyperreflective spots (C, D).
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F2
During a routine examination in 2013, we noticed retinal crystals, which surrounded and spared the fovea (Figure 2 A, B (Fig. 2)). Optical coherence tomography (OCT) showed hyperreflective dots mainly located in the superficial nerve fibre layer, which corresponded to the crystalline deposits and additionally punctate hyperreflectivity in the outer plexiform and nuclear layer (Figure 2 C, D (Fig. 2)).