PMC6590396_01
PMC6590396_02
Ocular surface with epithelial abnormalities. After the instillation of fluorescein dye in the tear film (blue cobalt light with yellow filter written n.12), the ocular surface revealed multiple patterns of epithelial abnormalities, which are seen as non-colored areas of the tear film (located at the same site during the various blinking). Clearly, the latter represent irregularities of the epithelial-basal membrane complex. When recurrent erosions occur, the site of epithelial defects corresponds to those of the epithelial blisters. If an epithelial defect lasts more than two weeks, it can be considered as "persistent" (or PED).
DDDT-13-2001-g0001.jpg
PMC6590396_02_DDDT-13-2001-g0001.jpg
F0001
In addition, the ocular surface was analyzed using by slit-lamp biomicroscopy (Figures 1 and 2).
Ocular surface with a persistent epithelial defect (PED). Epithelial defects are considered as "persistent" when they last at least 2 weeks without regression. In this image, after the instillation of fluorescein dye in the tear film (blue cobalt light with yellow filter Written n.12), this patient clearly showed a paracentral area of epithelial loss, which was refractory to the first-line treatment.
DDDT-13-2001-g0002.jpg
PMC6590396_02_DDDT-13-2001-g0002.jpg
F0002
In addition, the ocular surface was analyzed using by slit-lamp biomicroscopy (Figures 1 and 2).