PMC9247202_01
Routine gastroscopy revealed smooth mucosa in the gastric antrum (A), absence of gastric fold along the greater curvature of the gastric body (B), pale appearance of mucosa, increased visibility of vasculature, and multiple gastric submucosal bulges within gastric body, and fundus (B,C), EUS confirmed hyperechoic NETs originated from the muscularis mucosa, with an intact muscularis propria (D).
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F1
Routine gastroscopy revealed autoimmune gastritis, multiple gastric submucosal bulges, and no endoscopic features related to H. pylori status according to the Kyoto classification (Figures 1A-C). Endoscopic ultrasonography (EUS) revealed multiple submucosal bulges (Figure 1D), which were confirmed as G2 NETs in the gastric fundus, gastric body junction, and gastric body by histopathological examination of endoscopic biopsies (Figure 2).
Histological findings of pathological biopsies. (A) Hematoxylin and eosin staining (200x). (B) Ki-67 staining revealed the Ki-67 index was 15% and mitotic rate was 12. The carcinoid showed positive staining of CgA (C), Syn (D), CD56 (E), SSTR2 (F), CK (G), and negative staining for CD117 (H).
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F2
Endoscopic ultrasonography (EUS) revealed multiple submucosal bulges (Figure 1D), which were confirmed as G2 NETs in the gastric fundus, gastric body junction, and gastric body by histopathological examination of endoscopic biopsies (Figure 2).