PMC6497882_01
Neuroimaging examinations. The patient's first MRI brain scan (3 tesla), performed about 2 years into his illness. Panel A: Sagittal FLAIR T2 image highlights the marked frontal and cingulate atrophy. Panel B: The axial 3D FFE T1-w image shows bilateral anterior temporal lobe atrophy (right > left). Panel C: Coronal FFE 3D T1-w image shows fronto-insular and anterior temporal cortical atrophy, mainly on the right side.. Abbreviation: MRI, magnetic resonance imaging.
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 MRI brain scans (3 T) showed bilateral (right > left) fronto-temporo-insular and cingulate atrophy (Figure 1, Panels A-B-C); SPECT brain scan showed no right temporal lobe perfusion and hypoperfusion of the bilateral frontal lobes and left cingulate (Figure 2) and DAT-SCAN showed damage to the nigrostriatal dopamine system, ie right putamen, caudate nucleus (right > left) (Figure 3).
SPECT brain scan shows hypoperfusion of the right temporal lobe and hypoperfusion of the bilateral frontal lobes and left cingulate.. Abbreviation: SPECT, single-photon emission computed tomography.
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 MRI brain scans (3 T) showed bilateral (right > left) fronto-temporo-insular and cingulate atrophy (Figure 1, Panels A-B-C); SPECT brain scan showed no right temporal lobe perfusion and hypoperfusion of the bilateral frontal lobes and left cingulate (Figure 2) and DAT-SCAN showed damage to the nigrostriatal dopamine system, ie right putamen, caudate nucleus (right > left) (Figure 3).
Brain Dat-scan shows damage to the nigrostriatal dopamine system, in particular a loss of dopamine neurons in the right putamen and caudate nucleus (right > left).
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 MRI brain scans (3 T) showed bilateral (right > left) fronto-temporo-insular and cingulate atrophy (Figure 1, Panels A-B-C); SPECT brain scan showed no right temporal lobe perfusion and hypoperfusion of the bilateral frontal lobes and left cingulate (Figure 2) and DAT-SCAN showed damage to the nigrostriatal dopamine system, ie right putamen, caudate nucleus (right > left) (Figure 3).
CSF examination within the normal range for age (Abeta1-42771 pg/mL; tTau 276 pg/mL; nd 42.79 pg/mL; pTau181).. Abbreviations: MRI, magnetic resonance imaging; SPECT, single-photon emission computed tomography; CSF, cerebrospinal fluid.
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Imaging and CSF biomarkers indicated a neurodegenerative process that was not due to amyloidosis (Figure 4).