PMC7170404_01
Colonoscopy images showing areas of non-continuous colitis with scattered erosions. (A) Colitis of cecum, (B) non-continuous colitis, (C) colitis of transverse colon, (D-F) repeat colonoscopy images showing the resolution of previous colitis in the 3-month follow-up.
bmjgast-2019-000360f01.jpg
PMC7170404_01_bmjgast-2019-000360f01.jpg
F1
The colitis was non-continuous, with scattered erosions, demonstrated in figure 1.
(A) Photomicrograph showing colonic mucosa with lymphocytic infiltration (H&E, 100X); inset showing the predominance of lymphocytes, neutrophils, and plasma cells in the lamina propria. (B) Photomicrograph showing colonic mucosa with neutrophilic cryptitis in the background of the preserved crypt architecture that is characteristic of infectious colitis (H&E, 400X). (C) Photomicrograph showing Epstein-Barr virus-infected cells in the lamina propria (chromogenic in situ hybridisation, 100X). (D, E, F) Photomicrographs showing no infection with (D) HSV1, (E) HSV2, (F) CMV (immunohistochemistry, 100X). CMV, cytomegalovirus; HSV,
herpes simplex virus.
bmjgast-2019-000360f02.jpg
PMC7170404_01_bmjgast-2019-000360f02.jpg
F2
The histology and immunochemistry are further demonstrated in figure 2.