PMC3881083_01
Exophytic, corneal brown lesion located in the left nostril.
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The patient presented with an asymptomatic nodular growth and brown lesion measuring 5 mm in diameter and located in the left nostril of the nose (Figure 1); the patient had noticed the appearance of the lesion a few months previous to his visit to us.
A: Epithelial proliferation both above and below the level of residual epidermis (hematoxylin and eosin (H&E) stain); B: Keratin crypt formation at the surface of the lesion with hyperkeratotic epithelium and acanthosis (H&E stain); C: Epithelial proliferation containing a squamous eddy formation (H&E stain); D: High-power photomicrograph depicting base of inverted follicular keratosis with peripheral palisading of basaloid cells at the periphery of the tumor lobules and intercellular edema; E: Squamous eddy formation.
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The histopathologic findings, illustrated in Figures 2a-e show downward growth of the epithelium with intralesional corneal cystic inclusions, surrounded by nonspecific chronic inflammatory infiltration, with no evidence of cellular atypia.
Spontaneous regression of the inverted follicular keratosis
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Four months later, the patient reported a spontaneous regression of the remaining tumor (Figure 3).