PMC6505228_01
(a) Right chest breast mass, (b) chest X-ray, and (c) computed tomography of
chest (prior to thoracentesis).
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PMC6505228_01_10.1177_2324709619847230-fig1.jpg
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The patient reported having a right chest wall/breast mass since childhood but noticed significant worsening for several months prior to being seen (Figure 1a). An admission chest X-ray was notable for complete opacification of the right lung compatible with a large pleural effusion (Figure 1b). Further workup with computed tomography scan of the chest revealed a 6 to 7 cm mass in the right breast with right axillary adenopathy, a large right pleural effusion, and a 7-mm soft tissue nodule at the left lung base (Figure 1c).
Core biopsy of the right breast mass. (a) Invasive ductal carcinoma, (b)
estrogen receptor positive, and (c) GATA-3 antibody staining pattern: GATA-3
antibody appears to have an essential role in controlling genes that are
involved in differentiation and proliferation of breast cancer.
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PMC6505228_01_10.1177_2324709619847230-fig2.jpg
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The patient underwent an ultrasound-guided core biopsy of the right breast mass with pathology revealing invasive ductal carcinoma, grade 2, and positive for estrogen receptor (ER) 90%, progesterone receptor (PR) 1% to 5%, and human epidermal growth factor receptor 2 positive, equivocal by immunohistochemistry, and positive by FISH (fluorescence in situ hybridization; Figure 2a-c).