PMC4727271_01
Radiologic appearance of the tumor. a Mammography shows a dense mass with partially indistinct margin in the right breast. b Contrast-enhanced MRI shows a high-intensity lesion on T2- and diffusion-weighted imaging. c, d After 12 months of letrozole treatment, mammography reveals disappearance of the tumor (c) and MRI shows no evidence of tumor (d)
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Fig1
Mammography revealed a dense mass with partially indistinct margins (Fig. 1a), and ultrasonography showed a well-defined mass with rough borders measuring 21 mm in diameter. T1-weighted imaging and a high-intensity lesion on T2- and diffusion-weighted imaging (Fig. 1b). The kinetic curve showed a rapid-washout pattern suggestive of malignant disease. On preoperative examination, mammography revealed disappearance of the tumor (Fig. 1c). MRI likewise showed no evidence of tumor (Fig. 1d), and ultrasonography showed an area of low echogenicity measuring 7 mm in size, suggesting a treatment scar.
Histological findings of the biopsy and breast conserving surgery. a Histopathological examination reveals proliferation of cancer cells with papillary structures, accounting for over 90 % of the whole lesion, supported by arborizing fibrovascular stroma (hematoxylin-eosin). b Pathological examination shows fibrosis and elastosis, which was thought to represent tissue replaced by cancer cells after neoadjuvant chemotherapy. However, no viable cancer cells were found and pCR was diagnosed
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Fig2
Ultrasonography-guided needle biopsy was performed and histopathological examination revealed proliferation of cancer cells with papillary structures, accounting for over 90 % of the whole lesion, supported by an arborizing fibrovascular stroma (Fig. 2a). Pathological examination showed fibrosis and elastosis, which was thought to represent tissue replaced by cancer cells after neoadjuvant chemotherapy, but there is no viable cancer cells and pCR was diagnosed (Fig. 2b).