PMC6069891_01
Immunohistochemical stains demonstrated biphasic components. The carcinoma component (a) showed positivity for thyroglobulin (b). The sarcoma component (c) showed positivity for myogenin (d). All pictures are at 200x
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Fig1
TTF1 (Fig. 1). The sarcoma (spindled) component was negative for all thyroid carcinoma markers (TTF-1, thyroglobulin and PAX8), but was positive for vimentin and focally positive for myogenin (supporting skeletal muscle differentiation) consistent with mesenchymal differentiation.
Histological features of primary thyroid cancer and metastatic lung nodules. The epithelial component in the thyroid cancer (a) is morphologically similar to the epithelial component in the lung nodule (d). The sarcomatous component is composed of spindle cells both in the thyroid cancer (b) and in the lung nodule (e). There is vascular invasion in the thyroid cancer (c). Low power review of a small lung nodule (40x) in (f)
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Fig2
Histological examination of the lung nodules revealed similar tumor morphology and tumor differentiation when compared to the original thyroid tumor, which is somewhat unusual for a biphasic carcinosarcoma (Fig. 2).