PMC9741533_01
The tumor in the sigmoid fixated to the abdominal wall seen on CT in lateral cross-section.
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fig1
An urgent computed tomography (CT) scan was conducted which revealed an infiltrative process in the sigmoid colon (Figure 1) and probable metastatic lesions in the liver.
H&E slides demonstrate colonic adenocarcinoma with a clear cell component with clear cytoplasms: (a) 40x; (b) 100x.
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fig2
Histological examination revealed mucinous colon adenocarcinoma with a clear cell component (Figures 2 and 3).
Microscopic appearance of the clear cell component in the tumor: (a) 40x; (b) 100x.
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fig3
Histological examination revealed mucinous colon adenocarcinoma with a clear cell component (Figures 2 and 3).
Focal distribution of CK20 positive staining in the tumor (100x).
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A panel of histochemical and immunohistochemical reactions was done (Figures 4-6).
Strong nuclear CDX2 positive staining in the tumor (100x).
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fig5
A panel of histochemical and immunohistochemical reactions was done (Figures 4-6).
Alcian/PAS staining was negative in the tumor cells of the clear component: (a) 40x; (b) 100x.
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fig6
A panel of histochemical and immunohistochemical reactions was done (Figures 4-6).
Positive staining of the clear cell component for MMR: (a) PMS2 (100x); (b) MSH6 (100x); (c) MSH2 (100x); (d) MCH1 (100x).
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fig7
Mismatch repair protein (MMR) immunohistochemical testing was performed which yielded a positive reaction indicating that the tumor is negative for microsatellite instability (MSI-H) (Figure 7).