PMC4094021_01
(A) External virilization and ambiguous genitalia. (B) Genitogram demonstrating completely separate urethral and vaginal tracts. (C) Hematoxylin and eosin stain at 200x magnification of dysgenetic gonad with immature ovarian and testicular components. There are areas of solid tubules arranged in sheets and cords with immature Sertoli and germ cells admixed with dense, wavy ovarian-like stroma. Germ cells are noted adjacent to the basement membrane, and primitive seminiferous tubules are present in areas of decreased stromal density. (D) Streak ovary tissue composed of wavy ovarian-like collagenous stroma and scattered, small, and thin tubules. Classic monotonous germ cell tubules are seen closer to the capsule.
nihms599442f1.jpg
PMC4094021_02_nihms599442f1.jpg
F1
A right-sided streak ovary and left-sided dysgenetic gonad were found on both visual examination and histopathology (Figure 1C and D), consistent with the diagnosis of MGD.
PMC4094021_02
(A) External virilization and ambiguous genitalia. (B) Genitogram demonstrating completely separate urethral and vaginal tracts. (C) Hematoxylin and eosin stain at 200x magnification of dysgenetic gonad with immature ovarian and testicular components. There are areas of solid tubules arranged in sheets and cords with immature Sertoli and germ cells admixed with dense, wavy ovarian-like stroma. Germ cells are noted adjacent to the basement membrane, and primitive seminiferous tubules are present in areas of decreased stromal density. (D) Streak ovary tissue composed of wavy ovarian-like collagenous stroma and scattered, small, and thin tubules. Classic monotonous germ cell tubules are seen closer to the capsule.
nihms599442f1.jpg
PMC4094021_02_nihms599442f1.jpg
F1
A right-sided streak ovary and left-sided dysgenetic gonad were found on both visual examination and histopathology (Figure 1C and D), consistent with the diagnosis of MGD.