PMC5729639_01
Timeline of serum creatinine results and treatments for subject A.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
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F1
Two years after the KT, her graft function started to deteriorate gradually (Fig. 1).
Localization of the mutations in 4 patients. Subject A has a mutation of c.3644G>A, subject B has a mutation of c.3593A>T. Subject C has 2 mutations of c.3231T>G and c.3415C>T from both parents and subject D has a mutation of c.3572C>T.
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F2
At the age of 4 years, genetic analysis found a heterozygous mutation (c.3572C>T [p.Ser119Leu]) in CFH (Fig. 2), which was inherited from his asymptomatic mother.
PMC5729639_02
PMC5729639_03
Localization of the mutations in 4 patients. Subject A has a mutation of c.3644G>A, subject B has a mutation of c.3593A>T. Subject C has 2 mutations of c.3231T>G and c.3415C>T from both parents and subject D has a mutation of c.3572C>T.
jkms-33-e4-g002.jpg
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F2
At the age of 4 years, genetic analysis found a heterozygous mutation (c.3572C>T [p.Ser119Leu]) in CFH (Fig. 2), which was inherited from his asymptomatic mother.
Timeline of serum creatinine results and treatments for subject B.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
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F3
Soon after the KT, she experienced several recurrences of aHUS coinciding with infections, such as Pneumocystis pneumonia and chickenpox (Fig. 3).
PMC5729639_04
Analysis of CFH binding by western blotting in subject C. The control sample is from a normal person. Lanes 1, 2, and 3 are the patient's results: lane 1 is before the LT, lane 2 is 2 weeks after the LT, and lane 3 is 25 days after the LT. The plasma CFH levels in the patient increased to within the normal range after the LT.. CFH = complement factor H, LT = liver transplantation.
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F4
The patient's serum CFH expression detected by western blotting was relatively low compared to that in a normal control (Fig. 4). After the LT, her plasma complement and CFH levels normalized for the first time in her life (Fig. 4).
Timeline of serum creatinine results and treatments. (A) Subject C. (B) Subject D.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
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F5
After the operations, he has been free from aHUS for 14 months (Fig. 5B).
PMC5729639_05
Localization of the mutations in 4 patients. Subject A has a mutation of c.3644G>A, subject B has a mutation of c.3593A>T. Subject C has 2 mutations of c.3231T>G and c.3415C>T from both parents and subject D has a mutation of c.3572C>T.
jkms-33-e4-g002.jpg
PMC5729639_05_jkms-33-e4-g002.jpg
F2
At the age of 4 years, genetic analysis found a heterozygous mutation (c.3572C>T [p.Ser119Leu]) in CFH (Fig. 2), which was inherited from his asymptomatic mother.
Timeline of serum creatinine results and treatments. (A) Subject C. (B) Subject D.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
jkms-33-e4-g005.jpg
PMC5729639_05_jkms-33-e4-g005.jpg
F5
After the operations, he has been free from aHUS for 14 months (Fig. 5B).