PMC7728119_01
(a) Chondrosarcomatous differentiation within the malignant mesenchymal component; (b) The malignant mesenchymal component represented by an atypical fusocellular population, located in the immediate vicinity of the epithelial component that has the appearance of DCIS. HE staining: (a) x100; (b) x40. DCIS: Ductal carcinoma in situ; HE: Hematoxylin-Eosin
RJME-61-1-129-fig1.jpg
PMC7728119_01_RJME-61-1-129-fig1.jpg
F1
No axillary nodes metastasis (N 0/22) was found (Figure 1, a and b).
PMC7728119_02
(a) Mesenchymal-epithelial biphasic aspect: the fusocellular component is predominant and has condensation around the epithelial component; (b) Tubular structures devoid of myoepithelial cells, arranged in a desmoplastic stroma and accompanied by the hypercellular mesenchymal contingent; (c) Microscopic image with epithelial, tubular structures, positive for anti-p63 antibody. HE staining: (a and b) x100. Anti-p63 antibody immunostaining: (c) x200. HE: Hematoxylin-Eosin
RJME-61-1-129-fig2.jpg
PMC7728119_02_RJME-61-1-129-fig2.jpg
F2
The malignant mesenchymal component of the phyllodes tumor was described by immunohistochemistry (IHC) as smooth muscle actin (SMA) and cluster of differentiation (CD) 10 focally positive, CD34 and p63 positive (Figure 2c); CK AE1/AE3, c-kit, desmin, myoglobin, CK high molecular weight (CKHMW) were negative.
PMC7728119_03
(a) Epithelial contingent represented by ductal structures with DCIS lesions with cribriform and solid architecture; (b) DCIS lesions with micropapillary architecture, surrounded by a hypercellular mesenchymal contingent, composed of fusiform cells, with mild, mitotically-active atypia. HE staining: (a) x40; (b) x100. DCIS: Ductal carcinoma in situ; HE: Hematoxylin-Eosin
RJME-61-1-129-fig3.jpg
PMC7728119_03_RJME-61-1-129-fig3.jpg
F3
As for the mesenchymal component, a G2 malignancy was assigned (Figure 3, a and b).
PMC7728119_04
(a) Typical biphasic aspect with the predominance of the mesenchymal, hypercellular contingent, with nuclear atypia and mitotic activity; (b) Image of malignant epithelial component represented by a proliferation of epithelial cells with moderate atypia, arranged in trabeculae and focally drawing glandular lumens. HE staining: (a) x100; (b) x40
RJME-61-1-129-fig4.jpg
PMC7728119_04_RJME-61-1-129-fig4.jpg
F4