PMC4323913_01
A glomerulus with thickened glomerular capillary loops (a, PAS stain; x400) and spikes on Jones stain (arrow in b, x400). Immunoflourescence shows immunoglobulin G deposits (c), which on electron microscopy were subepithelial in location (d)
IJN-25-50-g001.jpg
PMC4323913_01_IJN-25-50-g001.jpg
F1
Jones silver stain revealed spikes [Figure 1].
Immunoflourescence study showing granular deposits of immunoglobulin (Ig) G3, C3 and Kappa along the glomerular capillary loops, while lambda is negative. Immunoflourescence for IgG1, IgG2 and IgG4 were negative
IJN-25-50-g002.jpg
PMC4323913_01_IJN-25-50-g002.jpg
F2
IgG, kappa light chain and deposition of monoclonal IgG3 and C3 along glomerular capillary loops with intensity being 3 + on a scale of 0-3+ [Figure 2]. IgA, IgM, lambda light chain and complement (C1q) were negative.