PMC7260585_01
Chest computed tomography scans on admission, showing multiple ground-glass opacities and interlobular septal thickening in both lungs. Arrow shows the location of one of the transbronchial lung biopsies, the right S2b.
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Chest CT revealed low attenuation areas, suggesting emphysema and diffuse GGOs along with interlobular septal thickening in both lungs (Fig. 1).
(A) Histological examination of the lung tissue obtained using a transbronchial lung biopsy demonstrating infiltration of signet-ring cell carcinoma cells into the alveolar septa (hematoxylin and eosin staining). (B-D) Immunohistochemical staining of tumor cells, negative for Napsin A (B) and positive for CDX-2 (C) and cytokeratin 20 (D).
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TTF-1, and Napsin A, and positive for CDX-2, cytokeratin 7, and cytokeratin 20) that infiltrated the alveolar septa in all specimens (Fig. 2). The tumor cells contained abundant intracellular mucin.