PMC10027483_01
Fig. 1 (A-C) Brain magnetic resonance imaging (MRI) at the age of 4 years showed hypomyelination with a discrepancy between T1- and T2-weighted images and increased white matter signal intensity is seen on T2 and fluid-attenuated inversion recovery (FLAIR) images in the supra- and infratentorial brain involving the external and internal capsules as well as the corticospinal tract in the brainstem, indicating extensive demyelination.
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PMC10027483_01_10-1055-s-0043-1764370-i2300004-1.jpg
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Neuroimaging was performed, including an MRI of the brain (see Fig. 1 ) performed at the age of 4 years, and showed clear characteristics of hypomyelination with a discrepancy between T1- and T2-weighted images.