PMC10321783_01
Preoperative vs postoperative clinical features and microscopic analyses: A - Clinical aspect of an exophytic irregular yellowish and dark red-violaceous nodular lesion in right ventral and lateral border of the tongue; B - After 18 months of follow-up, no recurrence was noticed; C - Photomicrograph showing squamous epithelium with acanthosis, hyperparakeratosis, and elongated rete ridges, which encompassed dilated and congested vessels. (H&E, 10X); D - Photomicrograph presenting vascular spaces delimited by normal-appearing endothelial cells containing inside numerous erythrocytes and proteinaceous eosinophilic material. (H&E, 10X).
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The intraoral examination revealed a painless exophytic irregular dark red-violaceous nodular lesion in the tongue's right ventral and lateral border and a similar papule in the ipsilateral dorsal region surrounded by white plaques (Figure 1A). After 18 months of follow-up, there were no signs of relapse (Figure 1B).
Immunohistochemical reactions. A - Most vessels showing positivity for CD34; B - Some vessels were highlighted by alpha-SMA; C - Focal positivity for D2-40. (DAB stain, 10X).
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Most vessels were CD34 positive; some were highlighted by alpha-SMA, whereas D2-40 was focal (Figure 2A-C).