PMC8577522_01
(A) Timeline of patient disease progression and treatment interventions. Sagittal (B) and axial (C) T2-weighted images, and sagittal (D) and axial (E) contrast-enhanced T1-weighted images of the lumbosacral spine were obtained on patient presentation in 2018. The 1.2 x 1.3 x 2.3 cm enhancing intradural extramedullary mass posterior to L3 is indicated by white arrows. (F) Copy number variation plot demonstrating chromosomal derangements present in the lesion.
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F1
A timeline illustrating this patient's disease course is shown in Figure 1A. T12-L1; Figure 1B-E). There was additional "sugar-coating" metastatic involvement of the distal spinal cord, but no abnormal enhancement in the brain. Whole chromosome events within the lesion included loss of chromosome 10 and gain of chromosome 7 (Figure 1F).
Pathologic findings: the glial neoplasm (A) identified in the resection specimen was GFAP-positive (B) and had vascular proliferation (*). Spinal cord from the autopsy showed the spinal dura mater to be expanded by the subarachnoid neoplasm (C) that surrounded the spinal cord but did not infiltrate it on cross-sections grossly (D) or microscopically (E). Original magnifications: A, 100x; B, 200x; E, 20x.
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F2
The neoplasm was diffusely positive for GFAP upon immunohistochemical analysis, with a Ki-67 of 30%-40% (Figure 2A and B). Subsequent autopsy showed the spinal subarachnoid space to be engorged by abundant glial neoplasm (Figure 2C-E).