PMC7364798_01
Primary central nervous system ALK-positive anaplastic large cell lymphoma. (a) The tumor effect from right occipital lobe to falx cerebrum with large area cerebral edema and partial cystis degeneration. (b) Tumor cells were arranged in diffuse monotonous growth pattern with focal ecrosis and starry-sky mimicking presented. (c) The neoplastic lymphoid cells were not large cells obviously. Nuclei of most tumor cells were subtle irregular-shaped and contain multiple basophilic nucleoli. The neoplastic cells stained strongly for CD30 on the cell membrane and in the Golgi region. (d) and ALK1 (e, f) FISH identified ALK gene break apart.
10.1177_2058738420941756-fig1.jpg
PMC7364798_01_10.1177_2058738420941756-fig1.jpg
fig1-2058738420941756
Head magnetic resonance imaging (MRI) examination showed a mass effect from right occipital lobe to falx cerebrum with large area cerebral edema and partial cystis degeneration (Figure 1(a)). Focal or sheets of necrosis and starry-sky mimicking presented (Figure 1(b)). Many mitoses could be easily found (Figure 1(c)). Immunohistochemical staining showed that neoplastic cells stained strongly for CD30 on the cell membrane and in the Golgi region (Figure 1(d)) and ALK1 (Figure 1(e)). Gene translocation involving ALK was identified by fluorescence in situ hybridization (FISH) using ALK break apart probe (Figure 1(f)).