PMC4802128_01
(A) 1.7 x 1.5-cm cervical mass with a homogeneous intensity on T1-weighted images and a heterogeneous intensity on T2-weighted images on posterior cervix.
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Magnetic resonance imaging (MRI) showed a 1.7 x 1.5-cm cervical mass with a homogeneous intensity on T1-weighted images and a heterogeneous intensity on T2-weighted images (Fig. 1).
The tumor was located in ecto-endocervix. HE X50.
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Signet ring cells were within pools of extracellular mucin (Fig. 2, Fig. 3).
The nuclei of tumor cells were diffusely positive for p16. p16 x400.
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An immunohistochemical study of the tumour showed positivity for p16 (Fig. 4), CDX-2, MUC1, MUC2 and MUC5AC and negativity for synaptophysin, chromogranin A and CK-20.