PMC10331224_01
Gallium-67 scintigraphy (A), showing high uptake in bilateral lacrimal glands, and magnetic resonance imaging, showing bilateral lacrimal gland masses in axial (B) and coronal section (C) at the initial visit at the age of 63 years.
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Gallium-67 scintigraphy showed abnormally high uptake only in bilateral lacrimal glands (Figure 1A) and magnetic resonance imaging demonstrated the enlargement of bilateral lacrimal glands (Figure 1B and C).
Right lacrimal gland extirpated at the age of 63 years. Infiltration with monotonous cells (A, hematoxylin-eosin), positive for cyclin D1 (B) and CD20 (D). Ki-67 labeling index was less than 1 % (C). Cyclin D1 was re-stained in 2021 with anti-cyclin D1 antibody (Abcam SP4, rabbit monoclonal, x150 dilution). Ki-67 was re-stained in 2023 (NCL-Ki67p, Leica Biosystems, rabbit polyclonal, x500 dilution). Scale bar = 200 microm.
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She underwent lacrimal gland extirpation on both sides in August 2004 and the pathological diagnosis was MCL, based on the infiltration with small monotonous cells (Figure 2A) which were positive for cyclin D1 (Figure 2B), CD5, CD20 (Figure 2D), and CD79a, but negative for CD3. Ki-67 labeling index was less than 1 % (Figure 2C).
Bone marrow biopsy at the age of 63 years. Infiltration with monotonous cells (A, hematoxylin-eosin), positive for cyclin D1 (B). Cyclin D1 was re-stained in 2021 with anti-cyclin D1 antibody (Abcam SP4, rabbit monoclonal, x150 dilution). Scale bar = 200 microm.
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After the completion of radiation, bone marrow biopsy revealed the infiltration with MCL (Figure 3A), positive for cyclin D1 (Figure 3B).