PMC4976160_01
A mass in the tail of the pancreas with (a) strong enhancement and with (b) rapid washout, MRI images.
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fig1
The patient underwent magnetic resonance imaging (MRI) which revealed a 3 cm, well-demarcated, enhanced mass in the tail of the pancreas (Figures 1(a) and 2(b)).
Histological examination. (a) The tumor shows well-defined borders with thick fibrous capsule (H&E x100). (b) Clear cells in solid nests and few tubules (H&E x200). (c) Clear cells in solid nests with round nuclei without atypia or mitoses (H&E x400).
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Microscopic examination of the neoplasm showed a tumor with well-defined borders with a fibrous capsule (Figure 2(a)) that consisted of clear cells located in solid nests with a few tubules (Figure 2(b)). The solid nests had round nuclei and were without atypia, mitoses, or necrosis (Figure 2(c)).
Immunohistochemical examination. (a) The tumor cells are positive for Cytokeratin-7 (Immunostain x200). (b) The tumor cells are positive for Cytokeratin-8/Cytokeratin-18 (Immunostain x200). (c) The tumor cells are positive for NSE (Immunostain x200). (d) Intracytoplasmic PAS positive granules (PAS x400). (e) Focal basolateral membranous staining for vimentin (Immunostain x400).
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Immunohistochemical examination revealed cells positive for each of the following: Cytokeratin-7 (Figure 3(a)), Cytokeratin-8/Cytokeratin-18 (Figure 3(b)), neurospecific enolase (NSE) (Figure 3(c)), and intracytoplasmic periodic acid-Schiff (PAS) (Figure 3(d)). All cells were negative for vimentin (Figure 3(e)).