PMC5917250_01
Fig. 1. A: Still frame of left coronary angiography showing restenosis in the proximal LAD. Letters in black correspond with the optical coherence tomography (OCT) images that follow. B-F: OCT from distal to proximal left anterior descending (LAD) and left mainstem demonstrating mature neo-intimal hyperplasia in mid-LAD stent (C, asterisk), aggressive immature neo-intimal hyperplasia in the proximal LAD stent (D, double arrowhead line) with tissue protrusion (E, arrowheads) and stent edge vascular response (F).
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F1
Coronary angiography demonstrated in-stent restenosisof the proximal LAD stent (Fig. 1A). Optical coherencetomography (OCT) demonstrated various tissue responses tostent implantation (Fig. 1B). High-signal, smooth muscle-richmature neo-intimal hyperplasia was present within the stent in themid-LAD (Fig. 1C; asterisk) whereas signal-poor homogeneousaggressive immature neo-intimal hyperplasia was present at thelevel of the proximal stent edge, causing sub-total occlusion (Fig. 1D; double arrowhead line), with tissue protrusion clearly visiblebelow the immature neo-intimal hyperplasia in certain frames(Fig. 1E; arrowheads). Proximal to the stent, an inhomogeneousedgevascular response was observed (Fig. 1F).