PMC4913156_01
The evolution of tumor burden is shown over 3 serial CT scans: 1) on 1/5/15 before starting afatinib 2) after stopping RRx-001 on 1/11/16 due to progression and 3) at the nadir of tumor regression (34.8% compared to 1/11/16) on 4/7/16 after 4 cycles of reintroduced carboplatin. Taken together the net percentage of tumor reduction from 1/5/15 to 4/7/16 was 54.6%. Target lesions are circled in red.
gr2.jpg
PMC4913156_01_gr2.jpg
fig2
Serial CT scans over an approximately 1-year timespan demonstrate that a significant decrease in tumor size occurred as a result of RRx-001 pretreatment prior to sequentially reintroduced carboplatin (Fig. 2).