PMC5698793_01
Colonoscopy showing severe ileal serpiginous ulceration and diffuse ileitis (Rutgeerts classification i4) before starting vedolizumab and ustekinumab therapy.
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Crohn's symptoms and iron deficiency anemia after receiving a retrial of infliximab with the addition of methotrexate combination therapy. Colonoscopy showed ongoing deep serpiginous ileal ulcers, colonic aphthous ulceration, and worsening deep rectal ulceration (Figure 1).
Colonoscopy showing ileal mucosal healing 6 months after starting vedolizumab and ustekinumab therapy.
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Colonoscopy 6 months after dual biologic therapy showed mucosal healing of the ileum and colon (Figure 2), which is the first time the patient has had mucosal healing since diagnosis.