PMC3622399_01
Fundus photographs and cytological examination of Case 1. Fundus photographs of (A) right and (B) left eye at the initial examination. Diffuse vitreous opacification can be seen in both eyes. (C) Atypical lymphocytes with anisonucleosis, aberrant chromatin, and dyskaryosis. Giemsa stain (400x). (D) Immunocytochemical findings (400x).. Note: Lymphoma cells are positive for leukocyte common antigen (LCA; arrows).
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At the initial examination, her best-corrected visual acuity (BCVA) was 20/25 in both eyes, and diffuse vitreous opacifications with aggregation of large cells were present in both eyes (Figure 1A and B). Atypical lymphocytes with anisonucleosis, aberrant chromatin, and dyskaryosis were detected by cytological analysis (Figure 1C). The lymphoma cells were positive for leukocyte common antigen (LCA: Figure 1D).
PMC3622399_02
Fundus photographs, fluorescein angiograms, and cerebral MRI of Case 2 obtained in 2008. (A) Central retinal vein occlusion can be seen in left eye: hyperemic swollen papilla, engorged veins, streaky retinal bleedings, and cottonwool spots. (B) Fluorescein angiograms showing staining of the walls of large veins, and no nonperfused areas in the left eye. (C) Cerebral MRI shows the tumor in paranasal sinuses (arrow heads), compressed optic nerve (arrow), and proptosis of the left eye.. Abbreviation: MRI, magnetic resonance imaging.
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He was diagnosed with central retinal vein occlusion of the left eye (Figure 2A and B), and diabetic retinopathy in both eyes, and diffuse large B-cell lymphoma of the paranasal sinuses (Figures 2C and 3) in November 2008.
Histopathological examination of paranasal-sinuses tumor of Case 2. (400x) (A) Atypical cells with anisonucleosis, aberrant chromatin, and dyskaryosis. Giemsa stain. Immunocytochemical findings. The cells are negative for T-lymphocyte surface antigen (CD3). (B) Immunocytochemical findings. The cells are negative for cytokeratin (AE1/AE3), a marker of epithelial cells. (C) Immunocytochemical findings. The cells are positive for B-lymphocyte surface antigen (CD20). (D) Immunocytochemical findings. The cells are negative for T-lymphocyte surface antigen (CD3).
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He was diagnosed with central retinal vein occlusion of the left eye (Figure 2A and B), and diabetic retinopathy in both eyes, and diffuse large B-cell lymphoma of the paranasal sinuses (Figures 2C and 3) in November 2008.
Cytological examination of infusion fluid of Case 2 (400x). (A and B) Atypical lymphocytes with anisonucleosis, aberrant chromatin, and dyskaryosis. (A) Giemsa stain; (B) Papanicolaou stain. (C) Immunocytochemical findings. Lymphoma cells are positive for B-lymphocyte surface antigen (CD20). (D) Immunocytochemical findings. Lymphoma cells are negative for T-lymphocyte antigen (CD3).
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From the infusion fluid, atypical lymphoid cells with large and irregular nuclei and prominent nucleoli were detected by cytological analysis (Figure 4A and B). T-lymphocyte surface antigen (CD3) (Figure 4C and D). The