PMC8645409_01
Panoramic radiograph revealed a multilocular radiolucency in the body and ramus of the mandible (a). Computed axial tomography revealed a large hypodense lesion exhibiting cortical bone destruction (b-e).
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A panoramic radiographic exam showed the presence of an expansive and multilocular radiolucent lesion, extending from the left condyle to the mandibular body (Figure 1(a)). Computed tomography revealed a hypodense area with cortical bone destruction (Figures 1(b)-1(e)).
HE staining revealed a neoplasm composed of sheets of spindle cells arranged in bundles and exhibiting a storiform pattern (a, b). Hyalinized collagen and myxoid areas were identified in some parts of the specimen (c). The neoplastic cells were positive for AE1/AE3 (d), CK-7 (e), and CD99 (g); diffusely positive for vimentin (f) and TLE-1 (h); and negative for CD34 (i), S100 (j), SMA (k), and HHF35 (l). Scale bar: A = 200 mum and B - L = 50 mum.
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Individually, the cells showed no defined limits with oval nuclei and loose chromatin (Figures 2(a) and 2(b)). In focal areas, hyalinized collagen and myxoid areas were identified (Figure 2(c)). The results showed that neoplastic cells were positive for vimentin and CD-99 (Figures 2(f) and 2(g), respectively). In focal areas of the tumor, the cells were positive for AE1/AE3 (Figure 2(d)), while SMA and HHF35 staining was negative for tumor cells (Figures 2(k) and 2(l), respectively). The tumoral cells showed focal expression of CK-7 (Figure 2(e)). TLE-1 was detected in nuclei of almost all tumoral cells (Figure 2(h)).