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PMC5066990_02
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Computed tomography scan of case 3.. Note: An irregular mass with a clear border, uneven density, and heterogeneous enhancement is visible.
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Radiological investigations revealed a mediastinal mass measuring 8 cm in its largest dimension (Figure 1).
Pathological results from an atypical thymic carcinoid.. Notes: A section of the mass from case 3 was observed under a light microscope (Olympus BX51; Olympus Corporation, Tokyo, Japan) after hematoxylin-eosin staining. Original magnification x100.
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Hematoxylin-eosin staining demonstrated that the tumor cells were arranged in a nested, trabecular, or pseudorosette pattern, with mild atypia and homogeneous staining in nuclei and chromatin in all three cases (Figure 2).
Immunohistochemistry results from an atypical thymic carcinoid.. Notes: Immunohistochemistry analysis of a tumor sample from case 3 demonstrating positive detection of CD56, CAM5.2, CgA, CK, and Syn (A-E, respectively). The staining index for Ki-67 (F) was between 5% and 20%. Magnification x100.
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Immunohistochemistry of tumor samples of the three cases demonstrated positivity for CD56, CAM5.2, CgA, CK, and Syn (Figure 3A-E), and staining indices for Ki-67 of between 5% and 20% (Figure 3F).