PMC8374937_01
Clinical photos. (A) Bilateral lung infection with a bilateral pleural effusion, a paraspinal mass of the right lower mediastinum, and pericardial effusion. (B) CT of pulmonary Talaromyces marneffei infection. (C) Enlarged spleen, multiple splenic lesions, cholecystitis, and peritoneal effusion. (D) Abnormality of the patient's toenails. (E) Rash on the patient's back due to Talaromyces marneffei infection. (F) Surgical exploration demonstrated intestinal perforation and edema of the surrounding mucosa.
fimmu-12-682350-g001.jpg
PMC8374937_03_fimmu-12-682350-g001.jpg
f1
However, two weeks after his admission, several scattered umbilical fossa-like red blisters began to appear on the patient's back, which gradually spread to both the upper limbs and the chest (Figure 1E); the blisters were not itchy but were painful. Intestinal perforation with erosion, ulcers and polypoid lesions could be seen during the operation (Figure 1D).
PMC8374937_02
Clinical photos. (A) Bilateral lung infection with a bilateral pleural effusion, a paraspinal mass of the right lower mediastinum, and pericardial effusion. (B) CT of pulmonary Talaromyces marneffei infection. (C) Enlarged spleen, multiple splenic lesions, cholecystitis, and peritoneal effusion. (D) Abnormality of the patient's toenails. (E) Rash on the patient's back due to Talaromyces marneffei infection. (F) Surgical exploration demonstrated intestinal perforation and edema of the surrounding mucosa.
fimmu-12-682350-g001.jpg
PMC8374937_03_fimmu-12-682350-g001.jpg
f1
However, two weeks after his admission, several scattered umbilical fossa-like red blisters began to appear on the patient's back, which gradually spread to both the upper limbs and the chest (Figure 1E); the blisters were not itchy but were painful. Intestinal perforation with erosion, ulcers and polypoid lesions could be seen during the operation (Figure 1D).
PMC8374937_03
Clinical photos. (A) Bilateral lung infection with a bilateral pleural effusion, a paraspinal mass of the right lower mediastinum, and pericardial effusion. (B) CT of pulmonary Talaromyces marneffei infection. (C) Enlarged spleen, multiple splenic lesions, cholecystitis, and peritoneal effusion. (D) Abnormality of the patient's toenails. (E) Rash on the patient's back due to Talaromyces marneffei infection. (F) Surgical exploration demonstrated intestinal perforation and edema of the surrounding mucosa.
fimmu-12-682350-g001.jpg
PMC8374937_03_fimmu-12-682350-g001.jpg
f1
However, two weeks after his admission, several scattered umbilical fossa-like red blisters began to appear on the patient's back, which gradually spread to both the upper limbs and the chest (Figure 1E); the blisters were not itchy but were painful. Intestinal perforation with erosion, ulcers and polypoid lesions could be seen during the operation (Figure 1D).
PMC8374937_04
(A) STAT1 GOF mutation sequence in the patient and his parents. The patient had a heterozygous mutation in exon 10 of the STAT1 gene (Y287N, nt.859T > A). The parents had no mutations. (B) Th17 assay. Peripheral blood mononuclear cells from the patient and a control were isolated and stimulated with phorbol myristate acetate and ionomycin. Intracellular IL-17 was measured by flow cytometry.
fimmu-12-682350-g002.jpg
PMC8374937_05_fimmu-12-682350-g002.jpg
f2
PMC8374937_05
(A) STAT1 GOF mutation sequence in the patient and his parents. The patient had a heterozygous mutation in exon 10 of the STAT1 gene (Y287N, nt.859T > A). The parents had no mutations. (B) Th17 assay. Peripheral blood mononuclear cells from the patient and a control were isolated and stimulated with phorbol myristate acetate and ionomycin. Intracellular IL-17 was measured by flow cytometry.
fimmu-12-682350-g002.jpg
PMC8374937_05_fimmu-12-682350-g002.jpg
f2