PMC6005282_01
(a) Presence of ectopic endometrium in the uterine wall (H&E, original magnification x10). (b) Cystic endometriosis present in the ovary (H&E, original magnification x10). (c) The adenomyosis in the uterine wall is surrounded by a stromal reaction evidenced by the CD10 positivity (ABC, original magnification x10). (d) The ectopic glandular epithelium of the cystic structure in the ovary expresses estrogen, as evidenced by immunohistochemistry with a monoclonal antibody specific for estrogen (ABC, original magnification x10).
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fig1
In detail, adenomyosis was described in the uterus because of the presence of ectopic glandular tissue in the muscular wall of the uterus (Figure 1(a)). On the other hand, at the level of the ovary, cystic enlargements filled with fluid were seen macroscopically; histologically, these cystic structures presented the classic glandular epithelium of the endometrium with one layer of cuboidal or tall cells, thus representing classic cystic endometriosis of the ovary (Figure 1(b)). Immunohistochemical staining was performed, by using the ABC method and diaminobenzidine, by means of specific antibodies for estrogen and CD10 in order to confirm the ability of the glandular epithelium to secrete estrogen and the presence of a stromal reaction surrounding the ectopic endometrial tissue (Figures 1(c) and 1(d)).