PMC7530229_01
Computed tomography revealed a localized mass that did not appear to invade the liver and swollen lymph nodes around the gallbladder.
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Computed tomography (CT) confirmed the same mass, which did not appear to invade the liver, and swollen lymph nodes around gallbladder (Fig. 1).
Magnetic resonance imaging of the gallbladder lesion showed low intensity on a T1-weighted image (a) and high intensity on a T2-weighted image (b) compared with the intensities of the liver parenchyma.
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Magnetic resonance imaging depicted the gallbladder lesion with low intensity on T1-weighted images and high intensity on T2-weighted images compared with the intensity in the liver parenchyma (Fig. 2a, b). 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) confirmed these findings (maximum standardized uptake value = 6.9) with no evidence of malignancy in other organs.
Endoscopic ultrasonography showed a hypoechoic trapezoidal-shaped protruding lesion of 25 x 12 mm in size. The thickened outer hyperechoic layer was preserved, which suggested no invasion to the liver parenchyma.
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The thickened outer hyperechoic layer was preserved, which suggested no invasion of the liver parenchyma (Fig. 3).
The resected specimen showed a submucosal tumour-like lesion of 28 x 15 mm in size (a). Split image of the tumour showed an expanding appearance and homogenous white colour (b). Haematoxylin and eosin staining showed lymphocytes mainly in the mucosal layer with muscular and subserosal propria invasion (arrow) (c).
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The resected specimen (Fig. 4a, b) presented a submucosal tumour-like lesion of 28 x 15 mm in size at the neck and body of the gallbladder on the liver bed side. Histopathologically, hematoxylin and eosin staining showed diffuse infiltration of atypical large-sized lymphocytes mainly in the mucosal layer with muscular and subserosal propria invasion (Fig. 4c).
Haematoxylin and eosin (HE) staining showed atypical large-sized lymphocytes (a). Immunohistochemical examination revealed the infiltrated lymphocytes to be CD3e negative (b) and CD20 (c) and CD79a (d) positive, which was similar to the pattern of histological findings of the specimen of right testis resected 8 years ago (e-h).
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Immunohistochemical examination revealed the infiltrated lymphocytes to be CD20 and CD79a positive, and CD3e negative, which was similar to the pattern of histological findings of specimen of the right testis resected 8 years ago (Fig. 5a-h).