PMC10408311_01
Computed tomography of the maxillofacial region showed a well-defined 25 mm x 16 mm osteolytic lesion involving the right mandible.
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Computed tomography of the maxillofacial region showed a well-defined 25 mm x 16 mm osteolytic lesion affecting the right mandible; erosion of the cortex was present (Figure 1).
Gross specimen showed bundles of spindle-shaped fibroblasts as well as foam cells (hematoxylin and eosin, x100).
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The gross specimen of the lesion showed whorled bundles of spindle-shaped fibroblasts (Figure 2), as well as foam cells, mingled with scant multinucleated giant cells, without any bone formation in the lesion.
Strongly and diffusely positive staining for SATB2 by immunohistochemistry (Envison, x200).
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The lesion showed strongly and diffusely positive staining for SATB2 (Special AT-rich sequence binding protein 2) (Figure 3), focal positive for SMA (Anti-smooth muscle antibody), KP1 (Anti-CD 68 antibody), and ER (Estrogen Receptor) (Figure 4), and negative for H3.3G34W by immunohistochemistry.
ER expressed in the NOF (Envision, x400).. NOF: non-ossifying fibroma.
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The lesion showed strongly and diffusely positive staining for SATB2 (Special AT-rich sequence binding protein 2) (Figure 3), focal positive for SMA (Anti-smooth muscle antibody), KP1 (Anti-CD 68 antibody), and ER (Estrogen Receptor) (Figure 4), and negative for H3.3G34W by immunohistochemistry.
USP6 break-apart fluorescence in situ hybridization.
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With respect to USP6 (Ubiquitin-specific proteases) break-apart fluorescence in situ hybridization, the result was negative (Figure 5).