PMC7502268_01
Patient's course of infection (top panel) and antimicrobial treatment (lower panel) is shown in (A). Grey shaded areas highlight fungal infections and antifungal treatments. Vertical dotted lines correspond to days of surgical intervention. Antimicrobial treatment was given either orally (red) or intravenously (IV, in orange). Infections were identified from urine (light green), intra-abdominal fluid (blue) or blood (dark blue) cultures. Bubble stamps in the top panel emphasize infections where evidence suggests that antimicrobial resistance emerged through distinct evolutionary process. The 'stamps' are as depicted in Fig. 1. (B) Resistance profiles of the various infectious agents over time as determined by the Clinical and Laboratory Standards Institute (CLSI) breakpoints with MIC measured with Sensititre: Resistant (red), intermediate (yellow), sensitive (light blue) and non-interpretable MICs (grey; embedded x indicates the measured MIC in microg/ml)
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Timing of antibiotics and resistance profiles of bacteria and fungi are summarized in Fig. 2.