PMC10151700_01
Representative image of a smear from a fine needle aspirate of the left renal mass. Cytologic examination of modified Wright's stained smears revealed moderate numbers of irregularly shaped dense clusters of medium to large (12-20 um) round to cuboidal cells. The cells had round to ovoid nuclei with fine chromatin and inapparent nucleoli. They had high nuclear to cytoplasmic ratios with small amounts of medium to dark blue cytoplasm with low numbers of discrete margined vacuoles. Based on the cohesive appearance, a cytologic diagnosis of carcinoma was made. Scale bar = 50 microns.
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F1
The nuclei within the cells were noted to be round to ovoid with nuclear crowding in clusters (Figure 1).
Computed tomography: coronal view of the abdomen with the caudal thorax at the top of the image, demonstrating a large, complex, multilobular mass arising from the left kidney (arrow).
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F2
A large, complex, multilobular mass arising from the left kidney was found (Figure 2).
Expression of IGF 2 represented by immunoreactive brown stain in ~50% of the cells within the cytoplasm; (inset) higher magnification of positive cells (arrow). Scale bar = 200 microns.
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F3
Immunohistochemistry for IGF-2 revealed that more than 50% of the neoplastic cells were immunoreactive with diffuse cytoplasmic granular staining (Figure 3).