PMC4151469_01
SNaPshot testing of biopsy of right upper lobe nodule after 3 months of erlotinib therapy. Multiplexed panel detecting mutational status of representative gene loci. Solid arrows indicate mutant peaks at EGFR and PI3Kca gene loci.
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F1
TKI therapy. The presence of the T790M mutation prior to EGFR TKI therapy together with the allele frequency of the T790M mutation from the SNaPshot results (Figure 1) made us consider the possibility of a germline EGFR mutation.