PMC4940021_01
Quantitative analysis of CaN-IR neurons: layers II-VI of the prefrontal cortex (BA46), hippocampus, caudate nucleus, and putamen.. Notes: In each histogram, "Sz" indicates the schizophrenia group, "cont" indicates the control group, and "tacrolimus" indicates the tacrolimus case. Analysis of covariance was used to compare the percentage of CaN-IR neurons among the three groups. (A) Percentage of CaN-IR neurons in each layer of the prefrontal cortex (BA46). (B) Percentage of CaN-IR neurons in each subfield of the hippocampus. (C) Percentage of CaN-IR neurons in the caudate and putamen.. Abbreviations: CaN-IR, calcineurin-immunoreactive; DG, dentate gyrus.
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f1-ndt-12-1645
The percentages of CaN-IR neurons in the BA46, hippocampus, caudate nucleus, and putamen are shown in Figure 1A-C. CaN-IR neurons among the schizophrenia group, healthy control group, and the tacrolimus case (all P>0.5, analysis of covariance). Compared with the healthy control group and schizophrenia group, the percentages of CaN-IR neurons in layers III-VI of the BA46 and the putamen tended to be lower in the tacrolimus case (Figure 1A and C).
CaN-IR neurons in brain sections from controls, patients with schizophrenia, and a patient with both schizophrenia and acute myelomonocytic leukemia treated with tacrolimus.. Notes: (A) Calcineurin-immunoreactive (CaN-IR) cells in the prefrontal cortex (BA46, layers V-VI) of a control brain (72-year-old male with a postmortem interval [PMI] of 12.5 hours). (B) CaN-IR cells in the prefrontal cortex (BA46, layers V-VI) of the brain of a patient with schizophrenia (48-year-old male with a PMI of 10 hours). (C) CaN-IR cells in prefrontal cortex (BA46, layers V-VI) in the brain of a patient with both schizophrenia and acute myelomonocytic leukemia treated with tacrolimus (31-year-old female with a PMI of 9.5 hours). Immunopositive neurons are indicated by arrows, and immunonegative neurons are indicated by arrowheads. Magnification x200.
ndt-12-1645Fig2.jpg
PMC4940021_01_ndt-12-1645Fig2.jpg
f2-ndt-12-1645
Representative images of CaN-IR neurons in the prefrontal cortex (BA46, layers V-VI) are shown in Figure 2.