PMC8613885_01
Clinical findings of the mass, arising in the internal surface of the left cheek.
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The overlying skin showed an angiomatous appearance (Figure 1).
CT scan imaging showing an infiltrative heterogenous mass of the left cheek (white star).
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Computed tomography (CT) showed an ill-defined, tissular mass, with heterogenous enhancement, measuring 78 x 54 x 38 mm (Figure 2).
PASCC histological features: pseudo vascular pattern: (A) hematoxylin and eosin, x100 and (B and C) hematoxylin and eosin, x400 (black arrow: pseudovascular channel).
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Neoplastic cells arranged in trabecula and irregular anastomosing channels due to tumor cell discohesiveness (Figure 3).
PASCC immunohistochemistry: the carcinomatous cells are p63 positive (A), AE1/AE3 positive (B), erg negative (positivity seen in stromal vessels) (C), CD34 negative (positivity in stromal vessels) (D) (immunohistochemical stain, x100).
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A large panel was made on immunohistochemistry, showing positivity for epithelial markers (AE1/AE3; EMA, p63, p40) with negative vascular markers (CD31, CD34, erg) (Figure 4).