PMC10276542_01
(a) Two-dimensional ultrasound imaging shows an irregular hyperechoic lesion in the right lobe of the liver with liquefaction in the center. (b) Contrast-enhanced ultrasound shows no contrast enhancement in any of the three phases.
j_biol-2022-0592-fig001.jpg
PMC10276542_01_j_biol-2022-0592-fig001.jpg
j_biol-2022-0592_fig_001
A contrast-enhanced ultrasound showed that there was no enhancement of the contrast medium at any time in the lesion, so it was considered to be focal necrosis with partial liquefaction (Figure 1).
(a) x100 and (b) x200: the proliferation of interlobular fibrous tissue, small focal lymphocytic infiltration, and irregular vascular lymphatics can be seen between them. The endothelial cells are arranged in the shape of spikes. (c) x200: CD31 (+++), CD34 (+++), FVIII-RAg (+), and Ki-67 <1%.
j_biol-2022-0592-fig002.jpg
PMC10276542_01_j_biol-2022-0592-fig002.jpg
j_biol-2022-0592_fig_002
Immunohistochemistry with a result of Cluster of Differentiation 31 (CD31) (+++), CD34 (+++), Factor VIII-Related Antigen (FVIII-RAg) (+), and Ki-67 (antigen identified by monoclonal antibody Ki-67) <1% led to a pathological diagnosis of hepatic RH (Figure 2).
Infiltration of lymphocytes and monocytes in the portal area (x100).
j_biol-2022-0592-fig003.jpg
PMC10276542_01_j_biol-2022-0592-fig003.jpg
j_biol-2022-0592_fig_003
A biopsy was taken again after 6 months, and the pathological examination showed only an infiltration of focal lymphocytes and monocytes in the portal area (Figure 3).