PMC4602651_01
Clinical features of the patient with extensive invasive EMPD. Ill-margined infiltrative erythematous lesion with a crusted, eroded, and scaly surface is covering on the extensive sites of penis, scrotum, left pelvic wall, hip, groins, and thigh. EMPD = extramammary Paget disease.
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F1
A 64-year-old Chinese man presented with a slowly progressive, ill-margined erythematous lesion with a crusted, eroded, and scaly surface involving multiple sites of penis, scrotum, left pelvic wall, hip, groin, and thigh for >4 years, which became extensive in the past 1 year (Figure 1).
Whole-body FDT PET/CT images demonstrated the presence of multiple FDG-avid lesions in the (A) anteroposterior 3D-MIP. The selected (B) coronal and (C-M) transaxial images revealed mild FDG uptake at the extensive cutaneous lesion with (B-E) subcutaneous invasion, involvement of (F-I) regional lymph nodes, and (J-M) multiple intense FDG-avid of skeletal metastases. 3D-MIP = 3-dimensional maximum intensity projection, FDG = fluorodeoxyglucose, PET/CT = positron emission tomography/computed tomography.
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F2
The anteroposterior 3-D maximum intensity projection (Figure 2A) image demonstrated extensive and invasive abnormal FDG-avid lesions in the body. Selected coronal (Figure 2B) and transaxial (Figure 2C-M) views of CT (left column), PET (middle column), and PET/CT (right column) fusion images revealed mild FDG uptake at the extensive cutaneous lesion with subcutaneous invasion (Figure 2B-E), involvement of lymph nodes (Figure 2 F-I), and multiple intense FDG-avid of skeletal metastases (Figure 2J-M).
Histological assessment of EMPD. Hematoxylin and eosin stain (x200) showed that the tumors were composed of cells with prominent nuclei and abundant lightly stained cytoplasm (suggesting Paget cells). EMPD = extramammary Paget disease.
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F3
Hematoxylin and eosin stain showed that the tumors were composed of cells with prominent nuclei and abundant lightly stained cytoplasm (suggesting Paget cells) (Figure 3).