PMC5449127_01
Sleep diary data of the patient from December 2015 to February 2016 (double plot).. Notes: Calculated from sleep onset and offset times recorded in a sleep diary, the mean (SD) time of the patient's sleep-wake cycle was 33.4 (10.1) hours. Aripiprazole (3 mg) was administered on December 17, 2015, and the patient's sleep-wake cycle was resynchronized ~1 month after administration, with a mean (SD) sleep-wake cycle of 24.2 (3.0) hours. The detailed clinical course is described in the text.. Abbreviation: SD, standard deviation.
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AM and awoke between 8 AM and 11 AM (Figure 1), similar to her sleep-wake pattern before she was diagnosed with N24SWD. Although the patient's depressive symptoms, including loss of energy, were not improved by treatment with aripiprazole (a CGI-S score of 4.0), her sleep-wake cycle remained synchronized on the same dose of aripiprazole for at least 6 months, and the mean (SD) time of the patient's sleep, awake and sleep-wake cycle were 9.9 (2.1), 14.3 (2.7) and 24.2 (3.0) h, respectively (calculated using sleep diary data between February 2016 and July 2016).