PMC3687426_01
Combined small cell and squamous cell carcinoma of the larynx. The microphotograph shows a collision phase of squamous cell carcinoma invasion and surrounding nests of small cell carcinoma (H&E, 200x)
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Histologic appearance of small cell carcinoma with an invasive squamous cell carcinoma part after hematoxylin and eosin staining is shown in Fig. 1.
Combined small cell and squamous cell carcinoma of the larynx. The chromogranin reactivity in the small cell carcinoma component is seen in this figure (ABC method, 200x)
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The immunohistochemical staining panel showed a diffuse positive reaction to synaptophysin and chromogranin A in the small cell neuroendocrine type carcinoma component (Fig. 2).
Combined small cell and squamous cell carcinoma of the larynx. The p63 reactivity is seen in the nuclei of the cells of the squamous cell carcinoma component (ABC method, 200x)
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The cells from the SCC component showed positive reaction to p63 (Fig. 3), to HMWCK and to cytokeratin 5/6 (CK5/6), while TTF-1 and p16 were negative.