PMC6295187_01
BCC, x100. A. Nodular type, HE staining; B. Adenoid type, HE staining; C. Morpheaform type, HE staining; D. Nodular type, Ki67 staining; E. Adenoid type, Ki67 staining; F. Morpheaform type, Ki67 staining
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PMC6295187_01_CHSJ-44-1-9-fig1.jpg
F1
In the periphery of tumor islets, tumor cells showed palisading or slit-like appearance (Fig.1A). In the case of adenoid BCCs, in addition to classical histopathological aspects, we found anastomosed cellular strands and a more desmoplastic tumor stroma (Fig.1B). For morpheaform BCCs, the tumor parenchyma was represented by one-two cell clusters surrounded by a densely collagenous stroma with numerous fibroblastic elements (Fig.1C). By comparison PI Ki67 mean value for nodular BCCs was 16.9+-5.4 ( Fig.1D-F).
Ki67 proliferation index depending on histologic type (A) and stage (B)
CHSJ-44-1-9-fig2.jpg
PMC6295187_01_CHSJ-44-1-9-fig2.jpg
F2