PMC5844257_01
Changes in liver function test values and azole antifungal serum levels during antifungal therapy.. Notes: Liver enzyme normal values (UI/L): GGT 8-16, ALP 40-129, ALT 7-41, AST 10-40. Serum bilirubin values are not represented, always kept within the normal range (0.2-1.2 mg/dL).. Abbreviations: GGT, gamma-glutamyl transpeptidase; ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase.
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Antifungal treatment was started with intravenous (iv) voriconazole (6 mg/kg twice daily as a loading dose followed by 4 mg/kg twice daily as a maintenance dose). At that time, liver function tests were as follows: gamma-glutamyl transpeptidase (GGT) 72 UI/L, alkaline phosphatase (ALP) 122 UI/L, alanine transaminase (ALT) 26 UI/L, aspartate transaminase (AST) 18 UI/L and total bilirubin 0.2 mg/dL (Figure 1).