PMC4925958_01
Pyogenic granuloma of the stomach (Case 1). (a) Endoscopic appearance of the 40 mm gastric polypoid nodule with surface erosion. (b-c) Histologically, a capillary hemangioma is present and arranged in a lobular pattern and filled with clusters of small capillary vessels ((b), x100; (c), x400). (d) Immunohistochemistry of CD31 highlighting the capillary proliferation (x400).
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Outside hospital esophagogastroduodenoscopy (EGD) revealed a 40-millimeter gastric polyp (Figure 1(a)). Histology from the polyp revealed inflammatory and hyperplastic changes with features of lobulated capillary hemangioma and granulation tissue (Figures 1(b)-1(d)).
PMC4925958_02
Pyogenic granuloma of the stomach (Case 2). (a) Endoscopic appearance of the 12 mm gastric polypoid nodule with surface erosions. (b-c) Histologically, a capillary hemangioma is present and arranged in a lobular pattern and filled with clusters of small capillary vessels and neutrophils infiltrate ((b), x100; (c), x400). (d) Immunohistochemistry of CD31 highlighting the capillary proliferation (x400).
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EGD revealed a twelve-millimeter, oozing, and pedunculated polyp in the distal antrum with migration into the duodenal bulb (Figure 2(a)). Histology from the initial biopsy and subsequent resection demonstrated fragments of foveolar hyperplasia and lobulated capillary hemangioma with focal granulation tissue, which is characteristic of PG (Figures 2(b)-2(d)).
PMC4925958_03
(a-b) Pyogenic granuloma of the stomach (Case 3). (c-d) Pyogenic granuloma of the ileum (Case 4). Low power views ((a) and (c), H&E, 100x) reveal gastrointestinal mucosa with variable ulceration. High power ((b) and (d), H&E, 400x) exhibits lobular arrangement of capillary proliferation and active inflammation.
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Histological examination of the resected small bowel revealed an incidental finding of PG at the site of Meckel's diverticulum (Figures 3(c)-3(d)).
PMC4925958_04
(a-b) Pyogenic granuloma of the stomach (Case 3). (c-d) Pyogenic granuloma of the ileum (Case 4). Low power views ((a) and (c), H&E, 100x) reveal gastrointestinal mucosa with variable ulceration. High power ((b) and (d), H&E, 400x) exhibits lobular arrangement of capillary proliferation and active inflammation.
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fig3
Histological examination of the resected small bowel revealed an incidental finding of PG at the site of Meckel's diverticulum (Figures 3(c)-3(d)).