PMC9733125_01
Non-contrast-enhanced CT image of the chest. Axial image in lung window setting (A) shows a well-delineated subsolid nodule in the paravertebral region of the right lower lobe. The lesion has a predominant ground glass appearance. A more prominent vessel is running through the lesion, but in mediastinal setting (B) no clear solid components can be delineated.
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F1
CT. Chest CT was performed six weeks later and showed persistence of the subsolid lesion in the right lower lobe (Figure 1A). The lesion has a predominant ground glass appearance since normal lung architecture with no clear solid areas in mediastinal window (Figure 1B).
Fused 18FDG-PET/CT image in axial plane shows moderate FDG uptake in the subsolid nodule in the right lower lobe.
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F2
Because of the large size of the lesion, 18F-FDG-PET was performed (Figure 2) and showed moderate FDG uptake.
Photomicrographs of the resected specimen. Overview (A) shows the lesion consisting of diffusely strongly widened septa infiltrated by the tumoral lymphoid cells. Importantly, the tissue architecture is densened by the tumoral infiltrate. Close-up image (B) shows the tumor in the alveolar septa. Yellow line shows remnant alveolar epithelium. The tumor consists of small lymphoid cells admixed with somewhat larger plasmacytic cells characterised by ample, slightly basophilic cytoplasm and an excentric nucleus.
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F3
Histopathologic examination showed an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Figure 3).