PMC4727195_01
Clinical course and variation in the serum levels of ALT, AST and T-Bil. ALT, alanine aminotransferase; AST, aspartate aminotransferase; T-Bil, total bilirubin.
ol-11-01-0085-g00.jpg
PMC4727195_01_ol-11-01-0085-g00.jpg
f1-ol-0-0-3853
Therefore, oral administration of regorafenib at 120 mg/day was initiated in October 2013 (Fig. 1).
Histological examination of liver tissue obtained by biopsy on day 50 post-initiation of regorafenib therapy. The sample slide was stained with hematoxylin and eosin, and observed by light microscopy at high power (magnification, x400).
ol-11-01-0085-g01.jpg
PMC4727195_01_ol-11-01-0085-g01.jpg
f2-ol-0-0-3853
Based on the histological examination of a specimen derived from liver biopsy conducted at day 50, which exhibited interface hepatitis with plasma cell infiltration (Fig. 2), regorafenib-induced autoimmune hepatitis was suggested.