PMC8267553_01
Growth chart and clinical events of case 1. The patient's linear growth accelerated
since about the age of 6 yr. GnRH agonist was started at 6 yr and 10 mo and was
stopped at 10 yr and 8 mo. Hydrocortisone was initiated at 10 yr and 11 mo. Breast
budding and menarche occurred at 11 yr and 2 mo and 11 yr and 10 mo, respectively. Her
adult height was 140 cm. Open and closed circles represent bone age and chronological
age, respectively.
cpe-30-143-g001.jpg
PMC8267553_01_cpe-30-143-g001.jpg
fig_001
Her linear growth had accelerated since she was about 6 yr old (Fig. 1), and her bone age (BA) was greater (9 yr and 0 mo) than her chronological age (CA: 6 yr and 8 mo).
Growth chart and clinical events of case 2. Hydrocortisone was initiated at 6 yr.
Breast budding occurred at 10 yr. GnRH agonist was started at 10 yr and 7 mo and was
stopped at 12 yr and 3 mo. Open and closed circles represent bone age and
chronological age, respectively.
cpe-30-143-g002.jpg
PMC8267553_01_cpe-30-143-g002.jpg
fig_002
Her BA (9 yr and 3 mo) was greater than her CA (6 yr and 4 mo) (Fig. 2).