PMC5328973_01
(A) Chest CT prior to hematopoietic stem cell transplant for patient 1 showing multiple masses due to EBV lymphoproliferative disease. (B) Multiple warts on the knee for patient 2.
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F1
At age 14, a persistent cough led to repeat CT scan, which showed two new areas of nodularity (1-2 cm) in her left lower lobe (Figure 1). Examination at age of 17 years found widespread warts on his elbows, knees, and the nape of his neck (Figure 1) and, during evaluation, he reported ongoing onychomycosis.
Pathology of the lung biopsy of the right lower lobe consistent with lymphomatoid granulomatosis. (A) 2x image showing large areas of necrosis. (B) 20x image showing lymphohistiocytic infiltrate with some large atypical lymphoid cells. (C) 40x image showing CD20 positive B lymphocytes by immunostaining. (D) 10x EBER showing EBV positive cells, including those in the vessel wall (arrow).
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F2
Grade 2 LYG (Figure 2). Given the rarity of EBV + LYG and her age, she was referred to the National Cancer