PMC6900610_01
Imaging and pathology of the initial CD5+ small bowel diffuse large B-cell
lymphoma. (A) Computed tomography scan showing isolated small bowel mass. (B
and C) Hematoxylin and eosin, original magnification x4 (B), x100 (C),
showing large centroblastic lymphocytes. (D) CD5, original magnification x4.
(E) CD79a, original magnification x50.
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Biopsy of the ileocecal mass (Figure 1) showed diffuse infiltrate of large (centroblast-like) lymphoid cells positive for CD20, CD5, CD23, CD43, BCL-2, BCL-6, c-MYC, MUM-1, and with Ki-67 of 60%.
Imaging, pathology, and genetic analysis of the relapsed CD5+ diffuse large
B-cell lymphoma. (A) Omental caking in abdomen. (B) Right-sided pleural
effusion with thoracic lymphadenopathy. (C) Bony lytic lesion in the right
femur. (D and E) Hematoxylin and eosin, original magnification x4 (D), x100
(E), showing large centroblastic lymphocytes. (F) CD5, (G) pleural
fluid:hematoxylin and eosin, original magnification x50, demonstrating large
centroblastic lymphocytes in pleural fluid. (H) Cytogenetic analysis showing
complex karyotyping. (I) Genetic sequencing analysis.
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Biopsy of the omental mass (Figure 2) confirmed progression of CD5+ DLBCL.