PMC5347374_01
Microscopically, the tumour consisted of elongated, anastomosing tubules separated by lakes of mucin from a prominent spindle cell area. The tubules were composed of low cuboidal cells with an amphophilic to eosinophilic cytoplasm with low-grade nuclei. Foci of sarcomatoid differentiation were seen with pleomorphic high-grade nuclei without any evidence of vascular invasion. Haematoxylin and eosin, 10x.
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F1
No lymphovascular invasion was noted (Figures 1 and 2).
MTSCC: Foci of sarcomatoid differentiation were seen with pleomorphic high-grade nuclei without any evidence of vascular invasion. Haematoxylin and eosin, 40x.
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F2
No lymphovascular invasion was noted (Figures 1 and 2).
The typical blue-coloured mucin in the stroma between the tubules and the cords. Alcian blue stain, 40x.
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F3
Alcian blue stain showed the typical blue-coloured mucin in the stroma between the tubules and the cords (Figure 3).
MTSCC: Immunohistochemistry showing diffuse positivity for cytokeratin in the tumour cells. IHC cytokeratin, 40x.
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F4
The tumour cells were diffusely positive for cytokeratin 7 (Figure 4), EMA and vimentin but negative for CD10.