PMC5928033_01
Firm flesh-colored nodules within the scrotal dermis before and after surgery.
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Physical examination (Fig. 1) revealed 5 prominent flesh/white colored firm and non-tender nodules within the scrotal skin that measured up to 10 mm in diameter.
Upper left. Hematoxylin and eosin stain (HE) of complete nodule. Upper right: HE stain revealed numerous amorphous calcified areas within the dermis. Lower left: Close look at calcified deposits. Lower right: Resection shows epidermis, dermis and subcutis. Epidermis shows hyperplastic epithelium with basal hyperpigmentation. In the underlying dermis and subcutis, numerous size variant of calcified deposits. There are no epithelial or melanocytic changes. No evidence of malignancy.
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The histopathological evaluation revealed the presence of calcium deposits with periinflammation and without cyst walls representative of the diagnosis ISC (Fig. 2).