PMC3025371_01
PMC3025371_02
(a) Endoscopic appearance of the ileal pouch before starting infliximab therapy showing diffuse inflammation. (b) Histology of the ileal pouch before starting infliximab therapy showing focal moderate ulceration and cryptitis with a crypt abscess. (c) Histology of the ileal pouch before starting infliximab therapy showing focal chronic regenerative glandular changes.
GRP2010-860394.001.jpg
PMC3025371_02_GRP2010-860394.001.jpg
fig1
After another severe exacerbation a year later, the pouch was found to be grossly inflamed with diffuse ulcerations (Figure 1(a)). The biopsies showed mild to moderate active chronic inflammation, cryptitis, and crypt abscesses without any granulomas (Figures 1(b) and 1(c)). 
PMC3025371_03
PMC3025371_04
(a) Normal endoscopic appearance of the ileal pouch after infliximab therapy. (b) Normal histology of the ileal pouch after infliximab therapy.
GRP2010-860394.002.jpg
PMC3025371_04_GRP2010-860394.002.jpg
fig2
The most recent endoscopy of the pouch (after two years of infliximab therapy) revealed completely normal mucosa with no inflammation (Figures 2(a) and 2(b)).