PMC3362186_01
Time course of blood tests: aspartate aminotransferase (U/l), alanine aminotransferase (U/l), bilirubin (micromol/l), lactate dehydrogenase (U/l), coagulation factor V (%), international normalized ration (INR), lactate (mmol/l) and ammonia (micromol/l).
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F1
Nevertheless, the patient developed acute liver failure, with rapidly rising transaminases and worsening coagulation (fig. 1).
Histopathological examination of the liver explant was suggestive of subacute toxic liver injury with little signs of histological recovery and without signs of underlying chronic liver disease such as fibrosis or cirrhosis. a Hypoplastic and hyperplastic hepatocytes. b Resorptive inflammation and ductular proliferation. c Ductular proliferates as a sign of regeneration (cytokeratin 7 immunostaining). d No preexisting fibrous septa or cirrhosis (Elastica van Gieson staining). e Sinusoidal fibrous septa seen as a sign of reparation (Sirius staining). Scale bars represent 200 microm in panels a-d and 100 microm in panel e.
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F2
Histopathological analysis of the liver explant revealed subacute toxic liver injury without signs of underlying liver disease (fig. 2).