PMC8107718_01
(A) Abdominal computed tomography revealed a relatively homogeneously enhancing mass in the left kidney (blue arrow) and a cystic lesion in the right kidney (red arrow). (B) Histology showed cells arranged in a single or multiple layers, which could be seen in some areas of the cyst wall. Cellular atypia, nucleoli, and mitosis were not obvious. (C) Necrosis and hemorrhage are visible in another area, and some suspicious infiltrating glands were seen in the fibrous stroma (yellow arrow). (D) In the postoperative pathological examination, we observed follicular architecture with micro- and macrofollicles containing eosinophilic secretions or colloid-like material in the cyst wall of the right kidney. (E) Follicular cells contained moderate eosinophilic cytoplasm and round nuclei. (F) The left renal tumor is a typical clear cell renal cell carcinoma.
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Abdominal computed tomography revealed a relatively homogeneously enhancing mass in the lower pole of the left kidney (4 cm in its greatest dimension) and a cystic lesion in the right kidney ( Figure 1A ). Cellular atypia, nucleoli, and mitosis were not obvious ( Figure 1B ). Obvious necrosis and hemorrhage could be seen in another area, and the fibrous tissue in the cyst wall was perforated; some suspicious infiltrating glands could also be seen in the fibrous stroma ( Figure 1C ). According to the postoperative pathology examination, we observed follicular architecture with micro- and macrofollicles containing eosinophilic secretions or colloid-like material in another area of the right renal cyst wall ( Figure 1D ). The follicular cells contained moderate eosinophilic cytoplasm and round nuclei ( Figure 1E ). The left renal tumor was a typical clear cell renal cell carcinoma ( Figure 1F ).
(A) Immunohistochemistry revealed that the tumor cells of the right kidney tumor were CK7-positive. (B) Immunohistochemistry also revealed that the tumor cells of the right kidney tumor were PAX2-positive. (C) Immunohistochemistry showed that the tumor cells of right kidney tumor were TTF1-negative.
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Immunohistochemistry revealed that the tumor cells of the right kidney tumor were positive for cytokeratin 7 (CK7) ( Figure 2A ) and paired Box 2 (PAX2) ( Figure 2B ) but were negative for transcription termination factor 1 (TTF1) ( Figure 2C ), thyroglobulin (TG), and synaptophysin (Syn).