PMC8062188_01
(a) CT scan showing mediastinal lymphadenopathy measuring 35.3 mm (marker); (b) CT scan showing bilateral axillary lymphadenopathies (arrows).
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fig1
The image findings obtained by the computerized tomography (CT) scan revealed homogeneous hepatomegaly with a bipolar diameter of 180 mm and splenomegaly with 146 mm of diameter without focal lesions and numerous lymphadenopathies located in multiple lymph node groups: left axillary, with the largest measuring 21.5 mm in diameter, mediastinum, supraclavicular, pelvic, and inguinal (Figure 1).
Lymph node biopsy showing features of Castleman disease, hyaline vascular type. (a) HE coloration, 10x amplification. Numerous small follicular structures, follicular dendritic type cells, and blood vessels, some with hyaline walls. (b) HE coloration, 20x amplification. Concentric layers of lymphocytes around the follicles, the mantle zone.
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fig2
The axillary lymph node biopsy (Figure 2) revealed numerous small follicular structures, with small centres containing CD21-positive follicular dendritic-type cells, endothelial cells, and CD20-positive small mantle lymphocytes arranged in concentric rings.