PMC6176286_01
Case 1. (a) On gross examination a polypoid mass filled the endometrial cavity. (b, c) The tumor comprised well-differentiated endometrioid carcinoma and UC whose component represented about 80% of the whole neoplasm (hematoxylin and eosin [HE]).
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fig1
The well-differentiated endometrioid carcinoma was confirmed on the surface of the endometrial polyp, and the coexisting UC showed a diffuse proliferation of atypical cells (Figure 1).
Case 1. (a) The tumor was composed of well-differentiated endometrioid carcinoma and UC with a sharp border (HE). ((b) ER, (c) PR) Differentiated components were strongly positive for ER and PR, whereas undifferentiated areas were not stained. (d) Pancytokeratin (AE1/AE3) was diffusely expressed in the well-differentiated carcinoma component and focally expressed in the UC component.
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fig2
Estrogen receptor (ER) and progesterone receptor (PR) were well expressed only in the differentiated carcinoma component (Figure 2).
PMC6176286_02
Case 2. (a) The tumor comprised moderately DEC and UC. (b) Pancytokeratin (AE1/AE3) was diffusely expressed in the well-differentiated carcinoma component and focally expressed in the UC component.
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fig3
Pancytokeratin (AE1/AE3) was diffusely expressed in the differentiated carcinoma component and focally expressed in the UC component (Figure 3).