PMC4427148_01
Fundus photographs of the right eye (a) and the left eye (b) of a patient complaining of blurred vision but with 20/20 vision in both eyes. Cuticular drusen can be seen as many small yellowish sub-RPE deposits.
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F1
An ophthalmoscopy showed many small sub-RPE deposits in both eyes (fig. 1a, b).
OCT of the right eye. Cuticular drusen (arrowhead) are seen as small nodular elevations of the RPE with a 'saw-tooth pattern'.
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F2
The SD-OCT images showed nodular elevations of the RPE which had a 'saw-tooth pattern' (fig. 2).
Fundus photograph (a), autofluorescence image (b), fluorescein and indocyanine green angiograms (c) and OCT image (d) of the left eye. a A fundus photograph shows cuticular drusen and subretinal hemorrhage. b An autofluorescence image shows mottled hyper- and hypofluorescent regions. c, d Fluorescein and indocyanine green angiograms showing a filling of the intraretinal neovascularization. The fluorescein angiogram has a 'stars-in-the-sky' appearance. Fluorescein leakage can be seen around the neovascularization. e OCT shows subretinal exudative changes (arrowhead) and a 'saw-tooth pattern' (arrow).
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F3
Six months after the initial examination, a fundus examination showed intraretinal hemorrhage (fig. 3a) in the left eye, and her visual acuity decreased to 20/40. Autofluorescencent images showed mottled hyper- and hypofluorescent regions (fig. 3b). Fluorescein and indocyanine green angiography by cSLO showed an early filling of an intraretinal neovascularization (fig. 3c, d) and late leakage. The fluorescein angiography images had a 'stars-in-the-sky' appearance in the area of the cuticular drusen, and the SD-OCT images showed subretinal exudative changes with a 'saw-tooth pattern' (fig. 3e).