PMC6344924_01
Hematoxylin and eosin staining (HE) of intraoperative frozen sections of lymph nodes showing large follicles without evidence of metastasis. Magnification, x20, x400.
rjz008f01.jpg
PMC6344924_01_rjz008f01.jpg
rjz008F1
Although the intraoperative frozen sections of the lymph nodes revealed no evidence of metastasis, large follicles were detected (Fig. 1).
Immunohistochemistry of sampled lymph nodes showing positivity for CD20, CD10, and Bcl-2 protein. Magnification, x20.
rjz008f02.jpg
PMC6344924_01_rjz008f02.jpg
rjz008F2
The tumor cells expressed CD20, CD10, and Bcl-2 (Fig. 2).
Hematoxylin and eosin staining of surgical specimens. (A) Specimens of the nipple showing Paget's disease and (B) Specimens of the tumor in the left lateral breast showing scirrhous carcinoma. Magnification, x40, x100, x400.
rjz008f03.jpg
PMC6344924_01_rjz008f03.jpg
rjz008F3
Because there was no continuity between invasive ductal carcinoma and Paget's disease, a diagnosis of synchronous multicentric breast cancer was made (Fig. 3).