PMC7060432_01
Kidney biopsy findings. (a) Periodic acid-Schiff and (b) Jones methenamine silver-stained sections demonstrate mild-to-moderate mesangial widening and minimal endocapillary proliferation with associated segmental double contours of the glomerular basement membrane. (c) C3-dominant staining is present in the mesangium and peripheral glomerular capillary loops. (d) Electron microscopy reveals subendothelial immune deposits with evidence of glomerular basement membrane reduplication.
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Light microscopy revealed mild to moderate mesangial widening, mild mesangial hypercellularity, and minimal endocapillary proliferation (Figure 1(a)). Segmental double contours of the glomerular basement membrane were identified, but no large subendothelial deposits or hyaline thrombi were seen (Figure 1(b)). On immunofluorescence microscopy, there was C3-dominant staining (2+) with less-intense IgM staining (1+) in the mesangium and scattered along the glomerular capillary loops (Figure 1(c)). Ultrastructural analysis revealed scattered subendothelial and mesangial electron-dense immune deposits with associated glomerular basement membrane reduplication and mesangial cell interposition (Figure 1(d)).