PMC9547027_01
PMC9547027_02
gross examination of the specimen showing a white beige neoplasm, encapsulated, with yellowish, necrotic and hemorrhagic areas (blue arrow)
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F1
Diagnosis: the gross examination of the specimen revealed a white beige neoplasm, encapsulated, measuring 19x18x17 cm, with yellowish, necrotic and hemorrhagic areas (Figure 1).
histological examination, hematoxylin and eosin stain, (A, 10x) and (B, 20x) showing the chromophobe renal cell carcinoma and high-grade sarcomatous component with sheets lipoblasts pleomorphics
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F2
The histopathological examination showed two distinct morphologic components, chromophobe renal cell carcinoma and sarcomatous component (Figure 2): the sarcomatous component was predominant and constituted of sheets lipoblasts pleomorphics with micro and macrovacuolated cytoplasms notching the nuclei in concave way.
immunohistochemistry, (A, 20x) and (B, 40x); chromophobe renal cell carcinoma showing positive reactivity for cytokeratin AE1/AE3
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F3
Immunohistochemically, Chromophobe renal cell carcinoma cells were positive for cytokeratin AE1/AE3 and cytokeratin 7 (Figure 3).