PMC9128425_01
(a) Histological staining of retrocorneal lesion. Epithelialization of endothelial cells, which show replacement of normal endothelial cells with larger hexagonal epithelial type cells with hematoxylin and eosin. (b) Immunohistochemistry staining of epithelial cells (positive pan-cytokeratin marker)
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F1
Descemet-stripping automated endothelial keratoplasty (DSAEK) surgery was done in July 2019. Descemet's membrane was sent for pathological examination and a diagnosis of epithelial ingrowth was confirmed [Figure 1a and b].
(a) Epithelial ingrowth, initial presentation (the arrowheads point to the edge of epithelial ingrowth). (b) The disappearance of epithelial ingrowth after 11 doses of methotrexate injections
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F2
A retrocorneal membrane with a defined border covering the peripheral corneal endothelium was noted on a slit-lamp examination [Figure 2a]. Eleven months after his last injection, there was no recurrence, but his vision was HM [Figure 2b].