PMC4341266_01
Cranial bone CT image of 3x3 cm bone defect on right occipital bone
PAMJ-19-124-g001.jpg
PMC4341266_01_PAMJ-19-124-g001.jpg
F0001
On cranial CT examination we detected a bony defect of 3x3 cm (Figure 1).
Gadolium enhancing cranial MR image of bone defect and surrounding lesion with high gadolinium enhancement
PAMJ-19-124-g002.jpg
PMC4341266_01_PAMJ-19-124-g002.jpg
F0002
Her gadolinium enhanced cranial MRI revealed bony defect along with massive gadolinium enhancement in adjacent tissue (Figure 2).
(a) fibrous dysplasia bearing "J" and "C" shaped irregular bony structures unaccompanied by osteoblastic/osteoclasticactivity. (Hematoxylin-eosin, original magnification x 100); (b)Hypercellular tissue intervening irregular shaped bony structures of fibrous dysplasia (Hematoxylin- eosin, original magnification x200); (c) Reticul in fibers forming characteristic "woven" bone pattern of fibrous dysplasia (Reticul in stain, original magnification x 100); (d) Characteristic "J" and "C" shaped irregular bony structures expressing intense and diffuse vimentin reactivity
PAMJ-19-124-g003.jpg
PMC4341266_01_PAMJ-19-124-g003.jpg
F0003
Bone trabeculae are in shape of "c" and "j" and some of them are fused with each other (Figure 3a). Microscopically findings of the case consist of bone lesion surrounded by compact bone tissue, mature lymphocytes that infiltrate fibrous tissue and dendritic cells (Figure 3b). On polarized filter examination, it has the characteristics of "woven bone" (Figure 3c). Conventional histochemistry doesn't reveal any PAS property; reticular formation with "woven" bone properties is seen on reticulin stain and collagen fibers with "woven" bone properties is seen on MTC stain (Figure 3d).