PMC7495152_01
Neck mass in a 17-year-old female. (a) Sections show a diffuse proliferation of intermediate-sized atypical cells with prominent nucleoli in a background of apoptotic debris and numerous tingible-body macrophages (hematoxylin-eosin, original magnification 40x). The tumor cells are positive for (b) CD20 (original magnification 40x), (c) CD10 (original magnification 40x), and (d) BCL-6 (original magnification 40x) and negative for (e) CD56 (original magnification 20x). The tumor cells show weak MYC expression (f) (original magnification 40x).
CRIHEM2020-8896322.001.jpg
PMC7495152_01_CRIHEM2020-8896322.001.jpg
fig1
Ki-67 highlighted a high proliferative index (Figure 1).
Flow cytometry from a neck mass in a 17-year-old female demonstrating neoplastic (a) CD20-positive B-cells with CD10 co-expression. The neoplastic cells demonstrate positive expression for (b) CD19, CD22, and (c) CD38 with (d) no CD16 or CD56 expression.
CRIHEM2020-8896322.002.jpg
PMC7495152_01_CRIHEM2020-8896322.002.jpg
fig2
Flow cytometry identified 86% of events as lymphocytes, a majority of which were B cells expressing CD45 (bright), CD20, CD19, CD10, CD22, CD38 (moderate-bright), FMC-7, CD23 (dim partial), and kappa light chain (Figure 2).
PET scan from a 17-year-old female showing a large FDG-avid right cervical mass, compatible with primary malignancy. No FDG-avid malignancy is identified elsewhere in the body.
CRIHEM2020-8896322.003.jpg
PMC7495152_01_CRIHEM2020-8896322.003.jpg
fig3
A positron emission tomography (PET) scan identified hypermetabolic activity (SUV 34.1) in the primary right level 2A cervical mass (5.8 x 4.1 cm) as well as a left level 2A lymph node (1.6 x 1.1 cm, SUV 2.4) (Figure 3).