PMC2648950_01
Patient 1.
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F1
Sensorineural hearing impairment was noted at 15 years of age and type 2 diabetes mellitus was diagnosed at 16 years of age (Figure 1).
Patient 1. Magnetic resonance imaging - morphologic appearance suggesting "empty sella".
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F2
The MRI study of the diencephalic and pituitary region was suggestive for the diagnosis of empty sella (Figure 2).
Patient 2. Normal MRI study of the diencephalic and pituitary region.
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F3
DEXA body composition analysis. Patient 2. Height/Weight: 167 cm/120 kg. Sex/Etnic: Female/White. Total region = 1,158 g/cm2 BMD1
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F4
We used Re-GH in this patient for 12 consecutive months, in a dose of 0,25 mg/day, with very good results: the total body fat mass decreased after one year, most significant in visceral trunk location as revealed by DEXA body composition, the bone density increased with 5% after 6 months (Figure 4).
Patient 2. Echocardiography: left ventricular mass index, fractional shortening and fiber shortening velocity improved after 12 month of low-dose therapy with Re-GH.
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F5
Echocardiography has shown that left ventricular mass index, fractional shortening and fiber shortening velocity improved after 12 month of low-dose therapy (Figure 5).
Patient 3.
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F6