PMC9298961_01
Biopsy specimens of cutaneous tubercle of the right tibia. Photograph showing local degeneration and necrosis of subcutaneous fat( ), revealing lymphocytic infiltration( ) with irregular nuclear morphology and nuclear rupture in the fat lobules, being in line with changes in nodular panniculitis. Specific stain: Periodic Acid Schiff Diastase (PAS-D) (-), Alcian blue (AB) (-). Direct immunofluorescence assay: IgG, C3, IgM, IgA (-).
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The pathological biopsy of the subcutaneous nodules indicated nodular panniculitis ( Figure 1 ).
Bone marrow smears showing hematopoietic cells ( ) and increased reticulocytes.
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Hemophagocytic cells were found in bone marrow aspiration ( Figure 2 ).
Clinical course and laboratory examination. IVIG, immu-noglobulin. (MP1 80-40mg daily, MP2 60-28mg daily, MP3 500-40mg daily, MP4 500-20mg daily, MP5 20-1mg daily).
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The abnormal laboratory findings all returned to normal ( Figure 3 ).