PMC4128839_01
Fundus and OCT findings at presentation for both eyes in case 1.. Notes: Fundus finding showed bilateral optic disc swelling (A and B) and disc hemorrhage superiorly in right eye (A) and macular edema with partial macular star at presentation (A and B) (A [right eye] and B [left eye]). OCT finding showed presence of bilateral subretinal fluid (C and D) (C [right eye] and D [left eye]).. Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; max, maximum; min, minimum; vol, volume; OCT, optical coherence tomography.
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Fundus examination showed features of bilateral neuroretinitis characterized by optic disc swelling with partial macular star (Figure 1A and B). Optical coherence tomography (OCT) showed presence of bilateral subretinal fluid with loss of foveal depression (Figure 1C and D).
Fundus and OCT findings at 6 weeks posttreatment for both eyes in case 1.. Notes: Fundus finding showed resolution of optic disc swelling and macular edema at 6 weeks posttreatment (A and B) (A [right eye] and B [left eye]). OCT finding showed resolution of subretinal fluid at 6 weeks posttreatment (C and D) (C [right eye] and D [left eye]).. Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; max, maximum; min, minimum; vol, volume; OCT, optical coherence tomography.
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After 6 weeks of systemic azithromycin therapy and oral prednisolone, there was improvement of visual acuity in the left eye (right eye: 6/9, left eye: 6/9) and bilateral resolving of optic disc swelling and macular star (Figure 2A and B). There was resolution of panuveitis and subretinal fluid in both eyes (Figure 2C and D).
PMC4128839_02
Fundus and OCT findings at presentation and follow-up for left eye in case 2.. Notes: Left eye showed optic disc swelling inferiorly associated with disc hemorrhage and macular edema at presentation (A). OCT showed presence of subretinal fluid at presentation (B). There was formation of partial macular star at 1-month follow-up (C), and resolution of optic disc swelling and macular edema at 2-month follow-up (D). Repeat OCT showed resolution of subretinal fluid at 2-month follow-up (E).. Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; max, maximum; min, minimum; OCT, optical coherence tomography; vol, volume.
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The macula was edematous with retinal exudates (Figure 3A). OCT of the left eye showed presence of subretinal fluid (Figure 3B). Follow-up at 1 month showed regression of optic disc swelling and resolving of macular edema with formation of partial macular star (Figure 3C). Two months after the initial visit, the visual acuity of the left eye had improved to 6/6 with complete resolution of optic disc swelling and macular edema (Figure 3D). Repeat OCT of the left eye showed resolution of the subretinal fluid (Figure 3E).
PMC4128839_03
Fundus and OCT findings at presentation and follow-up for right eye in case 3.. Notes: Right eye showed optic disc swelling with focal retinitis and macular edema with retinal exudates at presentation (A). OCT showed presence of subretinal fluid at presentation (B). There was formation of macular star at 1-week follow-up (C), and resolution of optic disc swelling and macular edema at 6-week follow-up (D). Repeat OCT showed resolution of subretinal fluid at 6-week follow-up (E).. Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; max, maximum; min, minimum; OCT, optical coherence tomography; vol, volume.
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There was presence of focal retinitis lesion at the temporal and superior margins of the optic disc (Figure 4A). OCT of the right eye showed presence of subretinal fluid (Figure 4B). There was formation of macular star of the right eye at 1-week follow-up (Figure 4C). There was regression of optic disc swelling and macular edema (Figure 4D). Repeat OCT of the right eye showed resolution of the subretinal fluid (Figure 4E).
PMC4128839_04
Fundus and OCT findings at presentation and follow-up for right eye in case 4.. Notes: Right eye showed optic disc swelling at inferior disc margin with macular star at presentation (A). OCT showed presence of subretinal fluid at presentation (B). There was prominent macular star and resolution of optic disc edema at 1-month follow-up (C). Repeat OCT showed resolution of subretinal fluid at 1-month follow-up (D).. Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; max, maximum; min, minimum; OCT, optical coherence tomography; vol, volume.
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Fundus examination of the right eye showed optic disc swelling at the inferior disc margin associated with macular star (Figure 5A). OCT of the right eye showed presence of subretinal fluid (Figure 5B). At follow-up at 1 month, there was improvement of visual acuity of the right eye, from 6/30 to 6/7.5, with regression of optic disc swelling and prominent macular star (Figure 5C). Repeat OCT of the right eye showed resolution of the subretinal fluid (Figure 5D).