PMC9178785_01
(A) The CT image of the patient's chest and abdomen. (B) The CT of the chest. A large soft tissue density mass was seen in the right breast, measuring approximately 17.1 cm x 13.2 cm x 17.2 cm, with clear borders, regular morphology, and uniform density.
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There was no abnormality in the nasopharynx on CT of the head and chest ( Figures 1A, B ).
(A) Section of the tumor showing tumor mesenchymal cell hyperplasia and unremarkable ductal epithelial hyperplasia (H&E x200). (B) Higher magnification of section in panel (A) showing moderate atypia of mesenchymal cells (H&E x400). (C) Immunohistochemical staining of this phyllodes tumor (IGF-2 IHC x200) and (D) higher magnification of the phyllodes tumor depicted in panel (C) showing positivity for IGF-2 in the cytoplasm of tumor mesenchymal cells and ductal epithelium (IGF-2 IHC x400). (E) Immunohistochemical staining of the control phyllodes tumor of breast obtaining from another woman without hypoglycemia (IGF-2 IHC x200) and (F) Higher magnification of the phyllodes tumor depicted in Figure 2E showing negativity for IGF-2 in the control tumor tissue (IGF-2 IHC x400).
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Postoperative paraffin pathology confirmed the right breast borderline phyllodes tumor ( Figures 2A, B ) with a maximum diameter of approximately 19 cm. Immunohistochemical staining of the phyllodes tumor with rabbit polyclonal anti-IGF-2 antibodies showed immunopositivity for IGF-2 in the cytoplasm of tumor mesenchymal cells and ductal epithelium ( Figures 2C, D ).