PMC7728113_01
Intraprocedural image of a voluminous pedunculated polyp, with irregular surface tubulo-villous appearance; SFI mode. SFI: Spectral focused imaging
RJME-61-1-235-fig1.jpg
PMC7728113_01_RJME-61-1-235-fig1.jpg
F1
The lesion responsible for the bleeding was a voluminous pedunculated polyp (2.5/1.5/1.5 cm, a pedicle of 0.8 cm diameter), with hemorrhagic regions, located in the sigmoid (Figure 1).
Colonic adenoma with low-grade dysplasia. HE staining, x40
RJME-61-1-235-fig2.jpg
PMC7728113_01_RJME-61-1-235-fig2.jpg
F2
Histologically, the excised fragment was identified as a tubulovillous adenoma with low-grade dysplasia, comprising multiple foci of complete and incomplete squamous metaplasia, similar to squamous morules commonly found in some endometrial carcinomas, as it can be seen in Figures 2,3,4,5,6,7.
Immunoexpression of p16 in the areas of squamous metaplasia. IHC staining, DAB chromogen, x100. IHC: Immunohistochemical; DAB: 3,3'-Diaminobenzidine
RJME-61-1-235-fig8.jpg
PMC7728113_01_RJME-61-1-235-fig8.jpg
F8
Ki67 was negative in the areas of squamous metaplasia, suggesting that those areas are mitotically inactive (Figures 8 and 9).
Absence of Ki67 immunoexpression in the areas of squamous metaplasia. IHC staining, DAB chromogen, x100. IHC: Immunohistochemical; DAB: 3,3'-Diaminobenzidine
RJME-61-1-235-fig9.jpg
PMC7728113_01_RJME-61-1-235-fig9.jpg
F9
Ki67 was negative in the areas of squamous metaplasia, suggesting that those areas are mitotically inactive (Figures 8 and 9).