PMC3388291_01
Chest CT of case 1 before chemotherapy demonstrating diffuse pleural dissemination of the tumor and irregular thickening of the bronchovascular bundle, indicating carcinomatous lymphangitis, and right pleural effusion (a). CT after two cycles of chemotherapy showing significant response (b).
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fig1
Four months later, the patient again developed dyspnea on exertion, and CT scan revealed increased size of the pulmonary tumor and diffuse pleural dissemination with thickening of pleurovascular bundles, indicating carcinomatous lymphangitis (Figure 1(a)). Chest radiograph and CT demonstrated significant disease regression (Figure 1(b)).
PMC3388291_02
Chest CT of case 2 demonstrating tumor of the right upper lung (a). CT after the first cycle of the chemotherapy demonstrated remarkable response (b).
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fig2
CT scan revealed multiple pulmonary metastasis and right hilar lymphadenopathy (Figure 2(a)). Combination chemotherapy consisting of pemetrexed, carboplatin, and bevacizumab was administered at the same dosage and schedule as Case 1. CT after the first cycle of triplet chemotherapy demonstrated significant disease regression (Figure 2(b)).