PMC9393490_01
Clinical photograph showing diffuse white lesions on ventral (a), dorsal (b), and lateral (c) surfaces of the tongue arising in a patient diagnosed with history of stem cell transplantation.
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Therefore, due to worsening of symptoms interfering with oral intake, the patient was referred to Oral Medicine department, College of Dentistry, University of Florida, for further evaluation (Figure 1). The floor of the mouth showed mixed red and white lesions with an average size about 1 cm (Figure 1).
Photomicrograph of biopsy specimen revealed severely thickened abnormal appearing epithelium with disturbed maturation pattern. (a) Severely thickened and keratotic epithelium exhibiting significant dysplasia with atypical arborization of the rete ridges (magnification 4x). The keratin layer is twice the thickness of the rest of the epithelium. (b) Islands of keratinizing invasive epithelium distributed randomly within connective tissue stroma (magnification 10x).
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A significant dysplasia with atypical arborization of the rete ridges and islands of keratinizing invasive epithelium distributed randomly within connective tissue stroma was present, and it was diagnosed as invasive squamous cell carcinoma (Figure 2).