PMC9730821_01
Tophi were found to have precipitated in the subcutaneous tissue and skin ulcerations were observed. The subcutaneous tophi deposits were similar to papules on the forearms, shins, and inner thighs and contained a chalk-like substance. Subcutaneous gout on the thigh also resulted in skin ulceration.
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Tophaceous deposits were found in subcutaneous tissues and multiple joints ( Figure 1 ), which had led to the development of articular deformities.
Fluctuations in body temperature during treatment. plasma adsorption.
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On the 4th day of hospitalization, the patient began to experience chills followed by high fever (Tmax 39.5 C) ( Figure 2 ) and arthralgia once again.
Inflammatory cytokines changes during treatment (A) TNF-a levels during the course; (B) IL-6 levels during the course; (C) IL-10 levels during the course; (D) changes of TNF-a, IL-6, IL-10 pre- and post- plasma adsorption). TNF-a, tumor necrosis factor-a; IL-6, interleukin-6; IL-10, interleukin-10. NS, not significant.
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Figures 3A-C ). This was accompanied by notable improvements in the clinical manifestations of gouty arthritis. Finally, there were 6 treatment sessions in total. However, due to the sharp fluctuation in the values and the small sample size, we did not find any significant difference in IL-6 and TNF-alpha before and after PA treatment ( Figure 3D ).