PMC6047856_01
Skin rash before and after treatment.. Notes: (A) Skin exfoliation on the back. (B) Dermal detachment and loose blisters on the right sole. (C) Back skin after several days of treatment. (D) Skin rash cured after treatment.
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f1-dddt-12-2163
T790M mutation was diagnosed, he started taking AZD-9291 with a dose of 80 mg/day to delay the disease progression. Twenty-one days later, he presented with several oral blisters and scattered erythematous maculopapular rashes, which rapidly developed into mucosal erosion and general epidermal detachment involving his entire body with exfoliation on his back skin (Figure 1A and B).