PMC7501957_01
Clinical case 1: baseline pre-FAc therapy SD-OCT from the RE (right panels) and the LE (left panels). The most relevant optical coherence tomography (OCT) characteristics included the presence of outer photoreceptor segment disruption, significant amount of hard exudates (HE), hyper-reflective foci (HF), disruption in outer plexiform layer (dOPL), presence of confluent cysts in outer nuclear layer (ONLc) and in inner nuclear layer (INLc), ONLc in comparison with INLc were particularly more evident in the RE.
IMCRJ-13-437-g0001.jpg
PMC7501957_01_IMCRJ-13-437-g0001.jpg
f0001
PMC7501957_02
Clinical case 2: A severe non-proliferative DR case with DME that was unresponsive to anti-VEGF and corticosteroids. Left, middle and right panels show fluorescein angiography, retinography and SD-OCT images, respectively, at baseline, pre-injection of the FAc implant. The SD-OCT shows external photoreceptor disruption, a significant amount of HE, HF, dOPL, presence of confluent and expressive ONLc and not so relevant INLc (Figure 4, right panel).
IMCRJ-13-437-g0004.jpg
PMC7501957_02_IMCRJ-13-437-g0004.jpg
f0004
A 60-year-old female with type 2 diabetes and DME described for the first time in the RE in 2011 against a background of severe non-proliferative DR (Figure 4; Table 2).
PMC7501957_03
Clinical case 3: Images shown of the RE (left panel) and LE (right panel). Retinography (top panel of images), fluorescein angiography (middle panel of images) and SD-OCT (bottom panel of images). The most relevant OCT characteristics included the presence of outer photoreceptor segment disruption, dOPL, presence of central confluent ONLc and INLc, with a relatively equivalent distribution of cysts between both nuclear layers in both eyes. The case shows recurrent DME as the patient case was responsive to IVI of triamcinolone and PRP. Patient lived a long way from the hospital, had PDR in the LE (i.e. the non-vitrectomized eye).
IMCRJ-13-437-g0007.jpg
PMC7501957_03_IMCRJ-13-437-g0007.jpg
f0007
Figure 7 shows the RE and LE status observed pre-FAc.