PMC6077533_01
Magnetic resonance imaging (MRI) findings of communicating hydrocephalus and leptomeningeal enhancement in the basal cistern at the time of initial manifestation of mental confusion (2012).
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However, a provisional diagnosis of communicating hydrocephalus caused by tuberculous meningitis was made based on MRI findings of leptomeningeal enhancement in the basal cisterns (Figures 1(a) and 1(b)). MRI of the brain showed multiple linear and nodular leptomeningeal enhancing lesions scattered in basal and left sylvian cisterns (Figure 1(c)). MRI of the brain surface revealed extensive progression of diffuse leptomeningeal enhancement in the basal and left sylvian cisterns (Figure 1(d)). MRI of the whole spine was subsequently performed in order to detect further leptomeningeal spread. MRI showed multiple leptomeningeal enhancing nodules displaying high signal intensity on T2-weighted images (Figure 1(e)), disseminating along the whole spinal cord without intramedullary lesion.
Histopathologic examination of disseminated leptomeningeal glioneuronal tumor.
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Histologic diagnosis revealed DLGNT without intraparenchymal brain lesion (Figure 2(a)). Monotonous oligodendrocyte-like or neurocyte-like tumor cells with round nuclei and clear cytoplasm were found (Figure 2(b)). Immunohistochemical stainings for Olig-2 and synaptophysin were positive (Figures 2(c) and 2(d)).