PMC4893446_01
Preserved lymph node architecture. Residual follicles with atretic germinal centers.
CRIM2016-1970276.001.jpg
PMC4893446_01_CRIM2016-1970276.001.jpg
fig1
Obliteration of subcapsular sinuses and regressed germinal centers in typically large follicles, some of which with "lollipop" features (onion skin appearance of the mantle zone lymphocytes and sclerotic blood vessels radially traversing into the germinal center), were detected (Figures 1 -3).
H-E regressed germinal centers (black arrows) surrounded by concentric layers of small lymphocytes (white arrows). Two follicles with hyaline-vascular changes (yellow arrow).
CRIM2016-1970276.002.jpg
PMC4893446_01_CRIM2016-1970276.002.jpg
fig2
Obliteration of subcapsular sinuses and regressed germinal centers in typically large follicles, some of which with "lollipop" features (onion skin appearance of the mantle zone lymphocytes and sclerotic blood vessels radially traversing into the germinal center), were detected (Figures 1 -3).
Lymphocytes in the mantle zone are positive (black arrows) for Bcl-2 and negative in the small regressed germinal center (white arrows).
CRIM2016-1970276.003.jpg
PMC4893446_01_CRIM2016-1970276.003.jpg
fig3
Obliteration of subcapsular sinuses and regressed germinal centers in typically large follicles, some of which with "lollipop" features (onion skin appearance of the mantle zone lymphocytes and sclerotic blood vessels radially traversing into the germinal center), were detected (Figures 1 -3).