PMC8101660_01
Clinical features of the intraoral OFMT. A - A painless nodule in the anterior region of buccal mucosa with approximately 2 years of duration; B - A well-circumscribed submucosal nodule with a smooth surface and normochromic in the anterior region of buccal mucosa measuring 1.3 cm in maximum diameter.
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Intraoral examination revealed a submucosal, smooth-surfaced, well-circumscribed, and normochromic nodule, which measured nearly 1.3 cm in maximum diameter (Figure 1).
Photomicrographs of the intraoral ossifying fibromyxoid tumor. A - A well-circumscribed tumor with a complete fibrous capsule that extended fibrous septa, separating the hypercellular area from other areas (H&E, 1.44x); B - Peripheral shell of lamellar bone within the fibrous capsule (H&E, 5x); C - The cells range from small round to oval to fusiform shapes, with bland nuclei with fine chromatin and indistinct cytoplasm borders. The hypercellular area exhibited less intercellular matrix, often showing nuclear overlapping (H&E, 20x); D - Intermediate cellularity (H&E, 20x).
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Few mitoses were also found, particularly in hypercellular areas (Figure 2 and Figure 3).
Photomicrographs of the intraoral ossifying fibromyxoid tumor. A - Hypocellular area with abundant fibromyxoid matrix (H&E, 20x); B - Hyaline material in the center of the lesion resembling chondroid or osteoid material (H&E, 10x).
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Few mitoses were also found, particularly in hypercellular areas (Figure 2 and Figure 3).
Immunohistochemical reactions of the intraoral ossifying fibromyxoid tumor. A - Vimentin showed cytoplasmic positivity in all tumor cells (20x); B - Intact nuclear expression of INI-1 in all tumor cells (20x); C - S100 exhibit nuclear positivity in the tumor cells; D - mainly in fibromyxoid and hyaline areas (20x).
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INI-1 nuclear expression was conserved in all tumor cells (Table 1, Figure 4, and Figure 5).
Immunohistochemical reactions of the intraoral ossifying fibromyxoid tumor. A - Ki67 was low (< 5%); B - however, in the hypercellular area had an increased rate (< 10%) (immunohistochemistry, 20x).
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INI-1 nuclear expression was conserved in all tumor cells (Table 1, Figure 4, and Figure 5).