PMC6942777_01
Thyroid gland pathology. Hematoxylin and eosin stain of histological sample from case 1, showing fibrosis and tissue distortion. Original magnification x20.
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Its histological study identified thyroid gland with follicles of different sizes, without oxyphilic changes, full of colloid material surrounded by abundant dense fibro-connective tissue with interspersed collagen and abundant lymphoplasmacytic inflammatory infiltrate with some eosinophils (Figure 1).
Thyroid gland pathology. Staining for IgG4. Multiple IgG4-positive cells were observed (brown color). Original magnification x40.
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Immunohistochemistry tests were performed, which were positive for IgG4 (Figure 2).
PMC6942777_02
Thyroid gland pathology. Hematoxylin and eosin stain of histological sample from case 2, showing fibrosis and tissue distortion. Original magnification x20.
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Microscopic visualization showed tissue with architectural distortion due to the presence of extensive fibrosis, with severe atrophy of the follicles, evident dense inflammatory infiltrate and abundant plasma cells (Figure 3).