PMC10130188_01
Timeline of main events and therapy regimens against arthritis and cancer. Created with BioRender.com
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Only marginal reduction in symptoms led to MTX up-titration over time, until elevated liver enzymes prompted a switch to LEF at ~1 year of treatment (Fig. 1). After several more months of therapy with LEF and intermittent prednisolone, which yielded unsatisfactory results, her treatment was escalated to TNF blockade with etanercept (Fig. 1). After postoperative recovery, the patient was started on adjuvant chemotherapy with six cycles of carboplatin and paclitaxel every 3 weeks, and addition of bevacizumab every 3 weeks for 15 months as per interdisciplinary tumour board recommendation (Fig. 1).
PMC10130188_02