PMC8246146_01
A-D: MRI of a mass lesion along the right-sided precentral gyrus. (A) FLAIR measurement showing a smooth bordered, hyperintense mass in the right precentral gyrus without significant perifocal edema. This lesion shows no contrast enhancement (B), but a circumscribed increase (C, arrow) of the regional cerebral blood volume (rCBV) as well as a clear increase (D, arrow) of the choline peak on MR spectroscopy (SVS SE 135).
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The structural focus of the seizures was a suspected low-grade right frontal precentral glioma detected on MRI (see Fig. 1A-D).
A1 + A2: Inflammation and reparation in a portal tract and loss of hepatocytes around the tracts. Additionally centroacinar necrosis is seen, indicating the damage (H&E, A1: original magnification 10x20, A2: 20x magnification). B: Fibrosis and beginning cirrhosis with increased portal and perisinusoidal collagen. Some of the portal tracts start to connect with each other gibing the aspect of a regenerative nodule (EvG, original magnification 10x20). C: Immunostaining for CK7 decorates increased number of cholangiocellular reactions in the ductal plate as a sign of regeneration (CK7, original magnification 10x20).
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There was significant parenchymal damage with corresponding accompanying cellular reaction and mild to moderately dense inflammatory cellular infiltration in the portal fields (see Fig. 2A-C).
Illustration of liver parameters AST (triangle), ALT (circle), GGT (square) and bilirubin (diamond) over time on days 1, 4, 7, 9, 14, 16, 18, 21 and as a late control after 203 days. Please note that AST, ALT and GGT parameters were measured in U/l, while bilirubin was measured in mg/dl.
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The time course of the liver serum parameters obtained as laboratory tests are displayed in Fig. 3.