PMC8116581_01
Fundus photographs and spectral-domain optical coherence tomography (SD-OCT) findings. Fundus photograph in 2012 (A) and in 2020 (B) showing bilateral optic disc temporal pallor with normal macula in both eyes. (C) SD-OCT foveal B-scan in 2012 revealing a normal ellipsoid zone (EZ) and a central foveal thickness (CFT) of 246 mum in the right eye (RE) and 239 in left eye (LE). (D) SD-OCT foveal B-scan in 2020 confirming a normal EZ and a CFT of 229 mum in the RE and 239 in the LE.
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F1
Fundus examination was stable over time showing bilateral optic disk temporal pallor with normal macula in both eyes and no signs of diabetic retinopathy (Figures 1A,B). Macular and optic nerve SD-OCT measurements were stable after 8 years of follow-up (Figures 1C,D, 2). RE and 239 mum in LE, with a preservation of the inner and outer retinal layers (Figures 1C,D). Regarding optic nerve analysis, in 2012 SD-OCT showed a reduction of the peripapillary RNFL, a suffering of superior and inferior axonal fibers of optic nerve in both eyes and of nasal axonal fibers in LE.
Retinal nerve fiber layer (RNFL) thickness evaluated with spectral domain-optical coherence tomography. Average RNFL thickness and RNFL symmetry did not change significantly throughout the follow-up period.
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F2
Macular and optic nerve SD-OCT measurements were stable after 8 years of follow-up (Figures 1C,D, 2). As shown in Figure 2 all these findings were stable during the follow-up.
Octopus visual field testing (32 standard). Above the exam performed in 2015 and below the exam performed in 2020, showing stable perimeter indices over the years.
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F3
Figure 3 shows Octopus visual field with values of a mean deviation of 6.5 dB in RE and 8.9 dB in LE in 2015, and a mean deviation of 6.2 dB in RE and 8.6 dB in LE in 2020.