PMC8667193_01
The bone marrow biopsy shows hypercellularity with increased megakaryocytes (A, H&E x40). The immunohistochemical studies show increased interstitial macrophages by CD68 (PGM1) (B, x40); and they are type 2 macrophages negative for pSTAT1 (C, x 0) but positive for CD163 (D, x40).
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CD68+ macrophages and atypical megakaryocytes; the macrophages are predominantly type 2 macrophages since they are negative for pSTAT1 and positive for CD163 (Figure 1). Chromosome analysis, acute myeloid leukemia (AML) FISH panel, next generation sequencing (NGS) for myeloid neoplasms (11 gene panel), and myeloproliferative neoplasm (MPN) panel (JAK2, CALR,
PMC8667193_02
The bone marrow biopsy shows hypocellularity with left-shifted myelopoiesis (A, H&E x 0). Immunohistochemical studies shows increased interstitial macrophages by CD68 (PGM1) (B, x40); they are type 2 macrophages (M2) negative for pSTAT1 (C, x 0) and positive for CD163 (D, x40).
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CD68+ macrophages, which were predominantly type 2 macrophages negative for pSTAT1 and positive CD163 (Figure 2). Chromosome analysis, AML FISH, NGS for myeloid neoplasms (11 gene panel),