PMC3921079_01
Scotopic electroretinograms elicited by a blue stimulus of 5.2x10-3 cd-s/m2 after 30 minutes of dark adaptation. The cone-rod mixed maximum response was elicited by a white flash of 44.2 cd-s/m2. The cone response and a 30 Hz flicker response were elicited by white stimuli of 4 cd-s/m2 and 0.9 cd-s/m2, respectively, on a blue background of 30 cd/m2. The electroretinograms were recorded on June 2010 and October 2012.
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Full-field rod ERGs were absent and cone-rod mixed responses were the negative type, indicating ON bipolar cell dysfunction (Figure 1). His visual field has not constricted and his ERGs have not changed (see Figure 1).
Fundus photographs of a patient diagnosed with carcinoma-associated retinopathy who developed choroidal atrophy during a 2-year follow-up period. Fundus photographs of the right (A) and left (B) eyes taken at the initial examination in June 2010. Fundus photographs of the right (C) and left (D) eyes taken in October 2012.
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However, fundus photographs taken in October 2012 showed diffuse choroidal hypopigmentation in both eyes (Figure 2). We also found that the choroidal vessels were more visible than those obtained at the initial examination (Figure 2).
Spectral domain optical coherence tomographic images showing progressive choroidal thinning. These images were recorded in June 2010 (A, right; B, left), July 2011 (C, right; D, left), and October 2012 (E, right; F, left). Arrowhead shows the lower border of the choroid.
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Spectral domain optical coherence tomography (Heidelberg Engineering, Heidelberg, Germany) showed a slight reduction in retinal thickness during the 2 years of follow-up, but the morphological architecture of the retina appeared almost normal at both times (Figure 3). Consistent with the choroidal hypopigmentation of the fundus, spectral domain optical coherence tomography showed a marked decrease in choroidal thickness over the 2-year period (Figure 3, arrowhead).