PMC4604645_01
Patternless sheets of primitive appearing neoplastic cells with hyperchromatic nuclei with neuropil
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F1
The histopathology report described a malignant infiltrating tumor present in sheets [Figure 1]. The tumor was composed of small oval to indented basophilic cells, exhibiting nuclear hyperchromasia [Figures 1 and 2].
Primitive appearing neoplastic cells with hyperchromatic nuclei, scant cytoplasm, and indistinct cell borders
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F2
The tumor was composed of small oval to indented basophilic cells, exhibiting nuclear hyperchromasia [Figures 1 and 2].
Tumor with areas of necrosis as indicated by the arrow (H and E, x20)
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F3
Extensive necrosis [Figure 3] and karyorrhexis were identified with areas of hemorrhage.
Neoplastic cells showing prominent mitotic figures as pointed out by the arrow (H and E, x40)
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F4
Brisk mitotic figures were also seen [Figure 4].
Tumor cells showing positivity for immunohistochemical stain CD56
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F5
The tumor cells showed positivity for immunohistochemical stain CD 56 [Figure 5].
Tumor cells showing focal positivity for immunohistochemical stain glial fibrillary acidic protein
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F6
Focal positivity for immunohistochemical stain glial fibrillary acidic protein was also seen [Figure 6].