PMC3843934_01
Scleromyxedema: nodular lesions on the face (a) and papular mucinosis on the neck (b).
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F1
Tender nodules of a hard consistency could be palpated bilaterally on the upper and lower eyelids, on the forehead, lateral parts of the nose, behind the ears and on the fingers (fig. 1).
Scleromyxedema: collagen fibers in the dermis are widely separated by mucin deposits (a, b). Nodular involvement of subcutaneous tissue (c). Fibroblasts are increased in number (d). Localization: trunk (a, b) and periorbital subcutaneous tissue (c, d). Stainings: HE (a, d) and Alcian blue (b, c).
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F2
Mucin deposition was demonstrated with Alcian blue staining (fig. 2).
Complete regression of nodular lesions on the face (a) and papular mucinosis on the neck (b).
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F3
Treatment with thalidomide was continued with a lower daily dose (50 mg/day) and finally discontinued in July 2011 due to complete disease remission (fig. 3).