PMC3804815_01
A) Unremarkable epidermis with tumor bulk in dermis 40x; B) Abundant mitotic activity and focal necrosis 100x; C) CEA 100x; D) CK7 100x; E) EMA 100x; F) GCDFP 100x.
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Microscopic examination revealed fairly well circumscribed but unencapsulated dermal nodule composed of solid sheets and trabeculae of cells with features of adenocarcinoma (Figure 1A). Abundant mitotic activity and focal necrosis were evident (Figure 1B). The overlying epidermis was unremarkable (Figure 1A). The carcinoma cells expressed carcinoembryonic antigen (CEA), Cytokeratin (CK) 7, epithelial membrane antigen (EMA) and Gross cystic disease fluid protein (GCDFP)-15, confirming the apocrine nature of the tumor (Figure 1C-F).