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A) Patient with chalazion-like induration of the left lower eyelid on July 11, 2008. B) High magnification of the lower eyelid with chalazion-like presentation. C) After one month, induration of the lower eyelid became rapidly enlarged. Note a diffuse, erythematous, thickened lower eyelid. D) High magnification of the thickened lower eyelid.
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On July 11, 2008, the patient noted an induration in the skin of her left lower eyelid (Figures 1A, B). However, the condition worsened rapidly, and swelling of the lower eyelid became remarkable (Figures 1C, D).
PMC2754084_04
A) Light micrograph of hematoxylin and eosin stained eyelid biopsy specimen. Lymphoma cells were infiltrated into the subcutaneous tissue. P, palpebral skin; Bar = 200 mum. B) High magnification of the lymphoma cells infiltrated in the orbicular muscles (arrows). Bar = 100 mum. C) Light micrograph of eyelid biopsy specimen immunostained with CD3 antibody. CD3 positive lymphoma cells were distributed in the subcutaneous tissue. Bar = 100 mum. Photographs of eyelids before D) and after irradiation E) The eyelid tumor was dramatically improved after irradiation.
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Pathological examination demonstrated that medium-sized lymphoma cells with round nuclei (Figures 2A, B) had infiltrated subcutaneously. CD3 (Figures 2C). Considering these results, the palpebral lesion was diagnosed as recurrence of PTCL. The eyelid tumor was dramatically improved after irradiation (Figures 2D, 2E).