PMC8556653_01
Chest CT showing a lung mass in the right upper lobe associated with large homolateral pleural effusion.
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Chest computed tomography (CT) showed a lung mass in the right upper lobe associated with large homolateral pleural effusion (Fig. 1).
PET/CT scan showing high FDG uptake at a lesion in the upper lobe of the right lung and a smaller lesion in the lower lobe of the left lung.
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Whole-body positron emission tomography (PET/CT) scan detected a high 2-[18F]FDG uptake lesion in the upper lobe of the right lung (SUVmax = 51,0) and a small lesion (SUVmax = 2,7) in the lower lobe of the left lung (Fig. 2).
Pleomorphic carcinoma comprising an undifferentiated non-small cell carcinoma component with large, pleomorphic cells (A and B) and rare giant multinucleated cells (B) admixed with a fusocelular component (H&E staining at 200x magnification).
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Histopathological examination was consistent with pleomorphic carcinoma comprising an undifferentiated non-small cell carcinoma component, with large pleomorphic cells and rare giant multinucleated cells admixed with a spindle-shaped component (Fig. 3).
Immunohistochemistry (IHC) images showing CKAE1AE3 expression (A) and beta-HCG expression (IHC at 200x magnification).
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The epithelial cell component showed focal expression for CK7 and did not express TTF-1 or P40 (Fig. 4).