PMC3860023_01
(a) Axial T1-weighted MRI, showing a hypoattenuating lesion, with a central area of low intensity indicating necrosis. Images 6 months (b) and 12 months (c) after treatment.
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T1-weighted images sized of 13 cm x 9 cm x 11 cm, and hyperintense on T2-weighted images (Fig. 1a). There was no mediastinal lymphadenopathy or brain involvement on CT scan. After 6 months, the lesion decreased in size to 7 cm x 5 cm (Fig. 1b). However, imaging studies have shown the persistence of a small calcified lesion of 3 cm x 1.5 cm (Fig. 1c).
Histopathology of the liver biopsy shows (a) normal hepatocytes and tumor cells (H&E, 100x) and (b) infiltration of large lymphoid cells (H&E, 400x), (c) positive CD45-LCA (100x), (d) positive cytokeratin in normal hepatocytes (100x), (e) positive Ki67 (400x) and (f) positive CD20 (400x).
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