PMC4227444_01
(a) Clinical appearance of the conjunctival mass lesion. Note that the globe is significantly displaced inferiorly. (b) Magnetic resonance imaging of the conjunctival mass lesion (arrow).
CRIM2014-614353.001.jpg
PMC4227444_01_CRIM2014-614353.001.jpg
fig1
His vision was 20/20 in each eye, and a complete ocular examination revealed normal findings, except for a mass lesion involving the superior bulbar conjunctiva of the right eye and significantly displacing the globe inferiorly (Figure 1(a)). The diagnostic impression on clinical and radiological findings was of a probable metastatic neoplasm (Figure 1(b)).
(a) Photomicrograph showing cellular neoplasm with darkly staining nuclei and scanty cytoplasm in the subepithelial stroma of the conjunctiva (stain, hematoxylin-eosin; original magnification, x200). (b) Photomicrograph showing intense immunoreactivity to thyroid transcription factor- (TTF-) 1, consistent with small cell lung cancer (stain, TTF-1; original magnification, x100).
CRIM2014-614353.002.jpg
PMC4227444_01_CRIM2014-614353.002.jpg
fig2
The highly cellular tumor was composed of small round to oval shaped cells with scant cytoplasm, finely granular chromatin, and absent or inconspicuous nucleoli, compatible with metastatic small cell lung cancer (Figure 2(a)). The tumor cells showed intense immunoreactivity to thyroid transcription factor- (TTF-) 1 and keratin, consistent with small cell lung cancer (Figure 2(b)).