PMC8175264_01
Axial (A) and coronal (B) computed tomography scan showing 12 x 12 x 18 cm mass at the tail of pancreas and splenic hilum. Histological sections of the lesion show that the lymphoma invades toward pancreas without infiltrating into pancreatic parenchyma (C) (hematoxylin and eosin x 20). Sections of the spleen reveal lymphoma cells infiltrating into splenic parenchyma with extensive necrosis (D) (hematoxylin and eosin x 40). Higher magnification shows a monomorphic population of large lymphocytes (E) (hematoxylin and eosin x 400). Immunohistochemical stain showing CD5+ expression by lymphocytes (F).
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Computed tomography imaging (Fig. 1A, B) demonstrated a 12 x 12 x 18 cm heterogeneous mass with central necrosis that arose from the pancreatic tail and extended into the spleen. The final pathological and cytological analysis showed diffuse large B cell lymphoma (Fig. 1C, F) arising from the spleen and involving the pancreatic tail, adjacent soft tissue, and lymph nodes.