PMC3198616_01
Disc photographs, Goldmann visual fields, and MR images of patient 1. (a)-(f) represent the initial episode in the right eye and (g)-(l) represent the recurrence in the left eye. Figure (e) is a coronal STIR image showing high signal within the right optic nerve, and Figure (f) is a coronal T1 fat saturation postgadolinium image showing associated optic nerve enhancement. (k) and (l) are coronal STIR and T1 postgadolinium images showing left optic nerve swelling and enhancement.
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fig1
Magnetic resonance (MR) imaging performed 2 weeks after the onset of her symptoms showed hyperintensity on STIR images and Gadolinium enhancement of the intraorbital portion of the right optic nerve (Figures 1(e) and 1(f)). MR imaging showed STIR hyperintensity and enhancement of the left optic nerve (Figures 1(k) and 1(l)).
PMC3198616_02
Goldmann visual fields performed on patient 2 at presentation of a recurrent episode of left retroorbital pain (a) and 2 months following treatment with intravenous methylprednisolone (c). The right eye had sustained an episode of optic neuritis previously (b and d).
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fig2
Visual acuity remained 6/5, and Goldmann perimetry was normal (Figure 2(a)). Her left visual function and visual field had remained unchanged on follow-up 2 months after treatment with intravenous methylprednisolone (Figure 2(c)).
PMC3198616_03
Coronal STIR image showing high signal within the optic nerve corresponding to the side of the pain in Case 3.
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fig3
MR imaging revealed STIR hyperintensity within the left optic nerve; no abnormality was detected within the brain (Figure 3).
PMC3198616_04
MR imaging of Case 4 showing extensive enhancement of the left optic nerve both intraorbitally (a) and intracranially (b).
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fig4
MR imaging showed extensive enhancement of the left optic nerve both intraorbitally and intracranially (Figure 4).
PMC3198616_05
PMC3198616_06
MR images of Case 6 showing gadolinium enhancement of the left optic nerve 24 hours after the onset of left retroorbital pain.
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fig5
MR imaging of the orbits with Gadolinium enhancement confirmed acute optic neuritis (Figure 5).
PMC3198616_07
PMC3198616_08
Goldmann visual fields showing minimal change in the left eye 1 month after a recurrent episode of optic nerve swelling (c) compared with visual fields performed 4 months before this recurrence (a). The contemporaneous right visual fields (b and d) are presented for comparison.
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fig6
Goldmann visual fields 4 months before and 1 month after this episode are shown in Figure 6.