PMC3148930_01
Cranial computed tomography scan revealed bilateral diffuse hypodensities over the subcortical white matter.
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Five months later (Figure 1), she became mildly forgetful.
Magnetic resonance imaging scan of the brain (sagital section) showing hyperintensities involving white matter.
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Cranial MRI done at this time showed multiple hyperintense periventricular white matter lesions on T2-weighted images (Figures 2, 3, and 4).
Magnetic resonance imaging scan of the brain (coronal section) showing hyperintensities involving white matter.
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Cranial MRI done at this time showed multiple hyperintense periventricular white matter lesions on T2-weighted images (Figures 2, 3, and 4).
Magnetic resonance imaging scan of the brain showing hyperintensities involving the temporal poles in the patient with cerebal autosomal dominant arteriopathy with subcortical infarcts and leuoencephalopathy.
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Cranial MRI done at this time showed multiple hyperintense periventricular white matter lesions on T2-weighted images (Figures 2, 3, and 4).
Mother's cranial computed tomography scan (2007) showing multiple ischemic changes and white matter hyperdensities.
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Her mother had had a history of seven years of subcortical dementia of unknown etiology, dysarthria, multiple ischemic changes, and white matter hypodensities on brain CT scan (Figure 5), prior to her death in 2007.
Pedigree of the family with cerebal autosomal dominant arteriopathy with subcortical infarcts and leuoencephalopathy (CADASIL).
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The patient's pedigree chart is shown in Figure 6.
Pathological changes in the capillary: capillary with granular osmiophilic material deposit located in pericyte infolding and thickened basement membrane showing collagen fibrils. In addition, endothelial cells are thin.
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The skin biopsy revealed characteristic granular osmiophilic material within the basement membrane surrounding the pericytes and smooth muscle cells of the small-sized and medium-sized vessels (Figure 7).