PMC5588201_01
a Heart histopathology:interstitial inflammation, focal necrosis (arrow) and disarray of myocardial cells. Hematoxylin and eosin stain. x100. b Heart histopathology:perivascular infiltrates of eosinophils and mononuclear cells (arrow), and some myocardial cells in disarray, undergoing necrosis. Hematoxylin and eosin stain. x400. c Lung histopathology: vascular congestion of alveolar wall capillaries (arrow) and alveolar damage. d Bone marrow: prominent active hemophagocytic CD68-positive macrophages. CD68 immunoperoxidase staining. x1,000.
mpp-0024-0195-g01.jpg
PMC5588201_01_mpp-0024-0195-g01.jpg
F1
The autopsy revealed EM with prominent interstitial edema and inflammatory infiltrate composed of eosinophils and mononuclear cells (fig. 1a, b). Vascular congestion of alveolar wall capillaries and alveolar damage were present (fig. 1c). Eosinophilic infiltrates were found in the stomach and skeletal muscles, while massive hemophagocytosis was observed in bone marrow and lymph nodes (fig. 1d).