PMC3714043_01
INR curve and timing of moxifloxacin administration in Case 1 (arrow pointing the day that patient received moxifloxacin).
JCHIMP-1-11512-g001.jpg
PMC3714043_01_JCHIMP-1-11512-g001.jpg
F0001
The trend of INR level in relation to moxifloxacin administration is illustrated in Fig. 1.
PMC3714043_02
INR curve and timing of moxifloxacin administration in Case 2 (arrows pointing the days that patient received moxifloxacin).
JCHIMP-1-11512-g002.jpg
PMC3714043_02_JCHIMP-1-11512-g002.jpg
F0002
His INR (Fig. 2) went up to 3.5, 24 hours after initiation of moxifloxacin (Day two in Fig. 2), 6.3 on Day three and then 6.9 on Day four, when he was admitted to hospital. Warfarin was resumed two days later (Day seven in Figure 2). His INR was mostly within the therapeutic range (Day 9 to Day 13 in Fig. 2) till the last two days, when it went up from 2.2 on day 13 to 5 on day 15.