PMC8566709_01
Clinical picture of the patient. Elevated, keloid-like, fine nodules coalescing into diffuse sclerodermoid plaques in a background of erythema were found on the right upper arm, chest wall, and abdomen.
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On examination, the chest wall and abdomen were diffusely indurated with erythematous nodules coalescing into diffuse sclerodermoid plaques in a background of erythema, and the right upper arm was also involved (Figure 1).
Skin histopathology of the patient. (A, B) Biopsy specimen of the chest showed single files or small clusters of monomorphous atypical cells with a cytoplasm rich in vacuoles seen in the dermis [(A) hematoxylin and eosin, x50; (B) hematoxylin and eosin, x100]. (C, D) Immumohistochemical staining showed the tumor cells were CK7+ (C) and ER+ (D) (x200).
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A biopsy of chest lesion showed a proliferation of monomorphous atypical tumor cells with a cytoplasm rich in vacuoles, presenting a single-file pattern or in small clusters (Figures 2A, B). Immunohistochemical staining revealed atypical cells were positive for cytokeratin 7 and estrogen receptor, but cytokeratin 20, progesterone receptor, and GCDFP-15 were negative (Figures 2C, D).