PMC4118728_01
Photomicrograph showing small-cell neuroendocrine carcinoma of cervix. (1a) H& E 10X and (1b) H&E 40X.
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A biopsy of the cervix revealed a small-cell neuroendocrine carcinoma of the cervix (Figure 1a & 1b) which explained the hyponatremia and neurological findings as of the paraneoplastic manifestation due to ectopic hormonal production by the tumour.
Immuno histochemistry of small-cell neuroendocrine carcinoma cervix showing positivity for (2a) chromogranin and (2b) synaptophysin.
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MRI pelvis showing well-defined iso-hyperintense lesion in the cervix (2.8 x 2.4 cm) and a large simple right ovarian cyst hypointense on T1Wand hyperintense on T2W.
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A magnetic resonance imaging (MRI) scan of the abdomen and pelvis revealed a well-defined iso-hyperintense lesion, 2.8 x 2.4 cm in the cervix, and a large well-defined cystic lesion 12 x 9.5 cm in size hypointense on T1W (T1 weighted image) and hyperintense on T2W (T2 weighted image) extending from the right lower abdomen into the pelvis posterolateral to the uterus, with no solid components/septations (Figure 3).
Type III radical hysterectomy and BSO showing right ovarian simple cyst (15 x 8cm); cervical tumour 3.5 x 3.5 cm, mainly involving the endocervix; and posterior vaginal flap tumour nodule.
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Also, a left parametrial nodule of 0.5 x 0.5 cm was identified which was removed in the specimen (Figure 4).