PMC6778923_01
(a) Infiltrating tumour masses. The tumour has infiltrated through the mucosa. (b) The tumour masses have invaded the serosa. The mucin lakes are delineated by thick fibrous bands of tissue (H&E stains, x40 magnification). (c, d) Infiltrating tumour cells. The tumour cells have signet ring shapes and are floating in lakes of mucin (H&E stains, x400 magnification).
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fig1
Microscopically, the tissue sections showed areas with mucosal infiltration of the tumour which was composed of lakes of mucin (Figure 1(a)), and the tumour had invaded to the level of serosa (Figure 1(b)). The tumour cells had abundant cytoplasm with hyperchomatic, pleomorphic, and densely stained nuclei which were pushed to the peripheral parts of the tumour cells giving the appearance of signet ring (Figure 1(c)), and in some areas the mucinous lakes were forming lobules (Figure 1(d)).