PMC3324272_01
Microphotograph of histopathological examination of third operated tumour showing uniform cellular tumour with spindle shaped cells of varying degrees of pleomorphism, vesicular eccentric nuclei with coarse chromatin and few mitotic figures; collagenous fibres arranged in intertwining whorled bundles; few areas of chondroid with no osteoid differentiation. The fat surrounding the tumour shows strands of normal breast tissue.
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The histopathological diagnosis from the last operative specimen was of fibrosarcoma of the breast (Figure 1) while the histopathological examination of both the earlier operative specimens were in favour of a phyllodes tumour (Figure 2a, 2b).
(a) Microphotograph of first surgical specimen: magnification 100X showing moderate stromal hypercellularity with mild nuclear atypia/pleomophism of the spindle cells and myxomatous stromal overgrowth. Focal mildly atypical epithelial hyperplasia was also noted, suggestive of phyllodes tumour (Borderline type). (b) Microphotograph of first surgical specimen: magnification 400X.
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The histopathological diagnosis from the last operative specimen was of fibrosarcoma of the breast (Figure 1) while the histopathological examination of both the earlier operative specimens were in favour of a phyllodes tumour (Figure 2a, 2b).
Photomicrograph of the histopathological slide after the final surgery: uniform spindle cells showing little variation in size and shape and a distinct fascicular arrangement. 400X magnification; H&E stain.
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The cells were spindle-shaped and varied little in size and shape, had scanty cytoplasm with indistinct cell borders, and were separated by interwoven collagen fibres arranged in a parallel fashion, favouring the diagnosis of fibrosarcoma (Figure-3).