PMC4061176_01
Surgical specimen of paraganglioma of vagina.
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The tumor mass was gray-white and taupe, with a size of 35x30x25 mm (Figure 1).
Vaginal tumor cells.. Note: Vaginal tumor cells showed nested aggregation and microscopically small nests composed of neoplastic cells having abundant cytoplasms demarcated by delicate fibrous stroma and capillaries in the Zellballen pattern (hematoxylin and eosin staining, 100x).
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In the tumor stroma, blood sinus, blood capillary, and little fibrous tissue could be found (Figure 2).
Positive immunohistochemical staining for chromogranin (400x) (A); positive immunohistochemical staining for synaptophysin (400x) (B).
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Synaptophysin, chromogranin A, protein S-100, neuron-specific enolase, cell proliferation-associated antigen Ki67, and vimentin were all positive, while smooth-muscle actin, human melanoma-associated antigen (HMB-45), and cytokeratin were negative in immunohistochemistry assay (Figure 3).