PMC6312798_01
In this patient with caecal adenocarcinoma, enlarged lymph nodes in the small bowel mesentery were resected and subjected to histologic and pharmacologic study. Drug concentrations in peritoneal fluid (PF) and plasma (PL) were also determined. Doxorubicin concentration in lymph nodes (LN) was markedly increased over that in plasma and was very similar to the intraperitoneal drug concentration between 60-90 min.
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Fig. 1 shows the pharmacokinetics of intraperitoneal doxorubicin in peritoneal fluid, mesenteric lymph nodes, and plasma.
PMC6312798_02
In this patient with malignant peritoneal mesothelioma, doxorubicin concentrations in peritoneal fluid (PF), plasma (PL), mesothelioma tumor nodules (TN) and lymph nodes (LN) within the small bowel mesentery were determined. High concentrations of drug were present within small tumor nodules bathed by the chemotherapy solution. Similar high concentrations of doxorubicin were present in lymph nodes buried within the mesenteric fat of the small bowel.
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The results of the doxorubicin within blood, peritoneal fluid, lymph nodes, and tumor are shown in Fig. 2.