PMC9153279_01
Timeline of tacrolimus trough concentration (black) and serum creatinine (grey) in patient A. Day 1 was day of admission. Dashed line indicates approximate tacrolimus trough concentration, above assay detection limit. Time bar (black) indicates days of rifampicin application.
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Figure1
Within the next 5 days, kidney function recovered (creatinine (discharge) 2.1 mg/dL) and tacrolimus concentration returned to therapeutic levels (tacrolimus C0 (discharge) 4.0 ng/mL) (Figure 1).
PMC9153279_02
Timeline of tacrolimus trough concentration (black) and serum creatinine (grey) in patient B. Day 1 was day of admission. Time bar (black) indicates days of phenytoin application.
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Figure2
Within 4 days, tacrolimus levels normalized (tacrolimus C0 (discharge) 4.3 ng/mL), and kidney function recovered (creatinine (discharge) 2.3 mg/dL) (Figure 2).