PMC5406799_01
Intraoral photograph showing large nonulcerated lesion with obliteration of buccal vestibule
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F1
Obliteration of buccal vestibule and missing regional teeth were noticed [Figure 1].
Occipitomental radiograph showing mixed radiopaque and radiolucent lesion in the right maxilla
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F2
Radiographic examination revealed the presence of a radiolucent resorptive lesion involving right maxillary residual ridge and maxillary antrum admixed with areas of radio-opacities [Figure 2].
Histopathology showing odontogenic epithelium and ghost cells in the epithelium and in the connective tissue with foreign body reaction (x10)
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F3
Active formation of dysplastic dentin in connective tissue stroma and prominent eosinophilic transformation of anucleated epithelial cell called "ghost cell" in epithelium and connective tissue resulting in multinucleated foreign body giant cell reaction were also present [Figure 3].
Van Gieson stain showing positivity toward dentinoid material
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F4
Van Gieson stain showed positivity for ghost cell and dysplastic dentin, whereas pan-cytokeratin positivity was observed in the odontogenic epithelial islands [Figures 4-7].
Immunostain showing strong positivity of odontogenic epithelial islands with pan-cytokeratin
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F5
Van Gieson stain showed positivity for ghost cell and dysplastic dentin, whereas pan-cytokeratin positivity was observed in the odontogenic epithelial islands [Figures 4-7].
Ghost cell (H & E, x40)
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F6
Van Gieson stain showed positivity for ghost cell and dysplastic dentin, whereas pan-cytokeratin positivity was observed in the odontogenic epithelial islands [Figures 4-7].
Foreign body giant cell reaction adjacent to ghost cell (H & E, x100)
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F7
Van Gieson stain showed positivity for ghost cell and dysplastic dentin, whereas pan-cytokeratin positivity was observed in the odontogenic epithelial islands [Figures 4-7].