PMC4737841_01
Cases 1~3 before (A), during (B), and after (C) application of capsaicin. The blue marker signifies the predetermined area of alloknesis to von Frey pinprick. Notice that the area of alloknesis is larger than that of hyperpigmentation, particularly in case 1 and 3 and to a lesser extent in case 2. As evident in all 3 cases (B and C), the erythema extends beyond the area of application highlighting capsaicin-induced activation of C-mechano-insensitive-fibers.
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PMC4737841_03_ad-28-86-g001.jpg
F1
Inspection revealed no visible skin alterations in the area where the itch was perceived : medially to the left scapula (Fig. 1, 1C).
Case 1 at follow-up (and 2nd treatment), 3 months following the initial treatment. Notice the significantly retracted area of alloknesis indicated by the black demarcation (Fig. 1A, B for comparison). The patient also exhibited diminished hyperpigmentation.
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F2
By the third treatment, the area of alloknesis had retracted by approximately 15%~25% (Fig. 2).
PMC4737841_02
Cases 1~3 before (A), during (B), and after (C) application of capsaicin. The blue marker signifies the predetermined area of alloknesis to von Frey pinprick. Notice that the area of alloknesis is larger than that of hyperpigmentation, particularly in case 1 and 3 and to a lesser extent in case 2. As evident in all 3 cases (B and C), the erythema extends beyond the area of application highlighting capsaicin-induced activation of C-mechano-insensitive-fibers.
ad-28-86-g001.jpg
PMC4737841_03_ad-28-86-g001.jpg
F1
Inspection revealed no visible skin alterations in the area where the itch was perceived : medially to the left scapula (Fig. 1, 1C).
PMC4737841_03
Cases 1~3 before (A), during (B), and after (C) application of capsaicin. The blue marker signifies the predetermined area of alloknesis to von Frey pinprick. Notice that the area of alloknesis is larger than that of hyperpigmentation, particularly in case 1 and 3 and to a lesser extent in case 2. As evident in all 3 cases (B and C), the erythema extends beyond the area of application highlighting capsaicin-induced activation of C-mechano-insensitive-fibers.
ad-28-86-g001.jpg
PMC4737841_03_ad-28-86-g001.jpg
F1
Inspection revealed no visible skin alterations in the area where the itch was perceived : medially to the left scapula (Fig. 1, 1C).