PMC7139170_01
Ochronotic deposits within the carotid plaque and intima.
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After carotid duplex showed high-grade (more than 80%) stenosis of right internal carotid artery (Figure 1), the patient was referred to vascular surgery for carotid endarterectomy.
H&E stain of carotid plaque:showing ochronotic (brownish) deposit near
the intimal wall with stripped layers of tunica media to the far left.
Atherosclerotic cholesterol plaque is depicted to the right of the
ochronotic deposits. A dense cholesterol-rich core is in the center with
right-sided pink-appearing thrombus.
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He was noted to have an impressive heavily brown-black pigmented discoloration of the carotid plaque as depicted in Figure 2.
Preoperative ultrasound imaging. Left panel shows internal carotid artery
high-grade stenosis with significant luminal stenosis. Right panel shows
velocities in proximal internal carotid artery.
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HGA deposits as black-brownish areas in the intima (Figure 3).