PMC5813913_01
Endoscopic picture of ulcers at the soft palate and gingiva with irregular margins, raised edges and erythematous floors.
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figure1
A screening upper endoscopy with narrow band imaging (NBI) showed multiple oral and pharyngeal ulcers with irregular margins, raised edges and erythematous floors (Figures 1 and 2), thick aryepiglottic folds (Figure 3), multiple small gastric fundic gland polyps and multiple small submucosal duodenal swellings (Figure 4).
Ulcer at the uvula with white light endoscopy (left) and NBI (right).
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figure2
A screening upper endoscopy with narrow band imaging (NBI) showed multiple oral and pharyngeal ulcers with irregular margins, raised edges and erythematous floors (Figures 1 and 2), thick aryepiglottic folds (Figure 3), multiple small gastric fundic gland polyps and multiple small submucosal duodenal swellings (Figure 4).
Thickened aryepiglottic fold (yellow arrow) suspicious of infiltration.
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figure3
A screening upper endoscopy with narrow band imaging (NBI) showed multiple oral and pharyngeal ulcers with irregular margins, raised edges and erythematous floors (Figures 1 and 2), thick aryepiglottic folds (Figure 3), multiple small gastric fundic gland polyps and multiple small submucosal duodenal swellings (Figure 4).
Multiple submucosal swellings at the second part of the duodenum as seen by white light endoscopy (upper left), NBI (lower left) and magnified view (right).
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figure4
A screening upper endoscopy with narrow band imaging (NBI) showed multiple oral and pharyngeal ulcers with irregular margins, raised edges and erythematous floors (Figures 1 and 2), thick aryepiglottic folds (Figure 3), multiple small gastric fundic gland polyps and multiple small submucosal duodenal swellings (Figure 4).
Histopathologic sections from oropharyngeal mucosa, stained by hematoxylin & eosin with different magnification powers (x4: left side, x8: right side); showing malignant lymphocytic infiltration with hyperchromatic enlarged nuclei and scanty cytoplasm.
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figure5
Histopathologic examination of pharyngeal biopsy revealed infiltration by malignant lymphoid cells with hyperchromatic enlarged nuclei and scanty cytoplasm (Figures 5 and 6) while immune-histochemical staining showed CD3 (+), CD4 (+) and CD8 (-) cells (Figures 7-9).
Histopathologic sections stained by hematoxylin & eosin from the same specimen with higher magnification powers (x20: left side, x40: right side).
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figure6
Histopathologic examination of pharyngeal biopsy revealed infiltration by malignant lymphoid cells with hyperchromatic enlarged nuclei and scanty cytoplasm (Figures 5 and 6) while immune-histochemical staining showed CD3 (+), CD4 (+) and CD8 (-) cells (Figures 7-9).
Immune-histochemical staining of the same sections showing CD3-positive cells (x20: left side, x40: right side).
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figure7
Histopathologic examination of pharyngeal biopsy revealed infiltration by malignant lymphoid cells with hyperchromatic enlarged nuclei and scanty cytoplasm (Figures 5 and 6) while immune-histochemical staining showed CD3 (+), CD4 (+) and CD8 (-) cells (Figures 7-9).
Immune-histochemical staining of the same sections showing CD4-positive cells (x20: left side, x40: right side).
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figure8
Histopathologic examination of pharyngeal biopsy revealed infiltration by malignant lymphoid cells with hyperchromatic enlarged nuclei and scanty cytoplasm (Figures 5 and 6) while immune-histochemical staining showed CD3 (+), CD4 (+) and CD8 (-) cells (Figures 7-9).
Immune-histochemical staining of the same sections showing CD8-negative cells (x20: left side, x40: right side).
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PMC5813913_01_can-12-801fig9.jpg
figure9
Histopathologic examination of pharyngeal biopsy revealed infiltration by malignant lymphoid cells with hyperchromatic enlarged nuclei and scanty cytoplasm (Figures 5 and 6) while immune-histochemical staining showed CD3 (+), CD4 (+) and CD8 (-) cells (Figures 7-9).