PMC10091230_01
Spatial arrangement of ascending colon tumor, sigmoid colon tumor, and carcinomatosis with MSS/pMMR and MSI-H/dMMR biomarkers, respectively. Remesz O. Intestinesall.svg. Wikimedia Commons, 2009.
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F1
Thus, the patient had two separate colonic primaries, both MSS by PCR and NGS, and a third metastatic adenocarcinoma that was MSI-H/dMMR and BRAFV600E mutated (shown in Fig. 1).
Timeline of tissue NGS and ctDNA NGS testing and therapeutic regimens of chemotherapy, immunotherapy, and surgical resection for patients with CRC.
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F2
Following surgery, she has received nivolumab without cytotoxic chemotherapy and has ongoing complete response to treatment (shown in Fig. 2).