PMC5871389_01
A - 6 cm-diameter tumor. B - Immediate
postoperative period
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f1
Dermatological examination revealed a vegetative and ulcerated tumor, friable, measuring 6cm in diameter, located in the right upper thoracic area (Figure 1). The patient underwent surgery with complete resection of the lesion and wide safety margins (Figure 1). 
A: Intense proliferation of pleomorphic cells in the dermis
(Hematoxylin & eosin, X200); B: Infiltration of adipose
tissue with neovascularization (Hematoxylin & eosin, X100);
C: Fusiform and polygonal pleomorphic multinucleated cells
with hyperchromasia of the nucleoli and mitotic figures (Hematoxylin &
eosin, X400); D: Immunohistochemistry 90% highly positive for
Ki-67 antibody, a cell proliferation marker, CD-68; E: A
macrophage marker (IHC, X200); and F: Vimentin, a mesenchymal
cell marker, IHC X100).
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PMC5871389_01_abd-93-01-0154-g02.jpg
f2
Histopathological examination associated with immunohistochemical (IHC) profile (Vimentin and CD68 positive) were compatible with undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma), but negative for other markers, such as high molecular weight cytokeratin, CD45, S100 protein, MELAN-A, HMB45, CD56, CD24, desmin, CD31, and Bcl2, which excluded other cancers, such as amelanotic melanoma, Merkel cell carcinoma, and lymphoma (Figure 2).