PMC5682635_01
Documentation of retinoblastoma control using spectral domain hand-held optical coherence tomography (HH-OCT). Following 6 cycles of intravenous chemotherapy for bilateral retinoblastoma, the left eye demonstrated small dome-shaped, outer retinal tumor recurrence (a) of 2750 microm in basal dimension and 792 microm thickness in the parafoveolar region, documented on HH-OCT (b) and with adjacent shallow subretinal fluid. The mass was 615 microm from the foveola. Following 1 cycle of intraarterial chemotherapy, the tumor showed complete regression (c) and HH-OCT (d) documented a concave scar of 120 microm in thickness and located 663 microm from foveola. There was OCT light transmission through atrophic retinal pigment epithelial accentuating the underlying thin choroid. The foveola remained intact
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Fig1
At 6-months follow-up, the right eye remained under control, but the left eye revealed a subtle recurrence of the juxtafoveal tumor (Fig. 1a) and HH-OCT (iVue Optovue, Fremont, CA) revealed an intact macula with adjacent tumor recurrence (Fig. 1b), measuring 2750 microm in diameter and 792 microm in thickness. Treatment with intraarterial chemotherapy (IAC) using Melphalan 5 mg was performed and complete tumor control was achieved with 1 cycle (Fig. 1c), leaving a concave scar of 2750 microm in diameter and 120 microm in thickness, located 663 microm from the foveola. In addition, there was underlying choroidal thinning and preservation of the foveal microanatomy documented by HH-OCT OS (Fig. 1d).