PMC4722732_01
On contrast-enhanced CT, the tumor demonstrated marked enhancement in the arterial phase
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PMC4722732_01_12957_2016_771_Fig1_HTML.jpg
Fig1
On contrast-enhanced CT, the tumor demonstrated marked enhancement in the arterial phase (Fig. 1).
Pathology slides of the resected specimen with different stains. a Hematoxylin and eosin staining demonstrating the classic Zellballen pattern of paraganglioma (HE, x400). b The chief cells showed positive staining to NSE (IHC, x400). c The chief cells showed positive staining to Syn (IHC, x400). d The sustentacular cells showed positive staining to S-100 (IHC, x400)
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PMC4722732_01_12957_2016_771_Fig2_HTML.jpg
Fig2
Histological examination showed that the tumor was composed of well-defined nests of cuboidal cells separated by vascular fibrous septa, forming the classic Zellballen pattern (Fig. 2a). The chief cells showed positive staining to neuron-specific enolase (NSE) (Fig. 2b), chromogranin A (CgA), synaptophysin (Syn) (Fig. 2c), but showed negative response to vimentin (Vim), endomysial (EMA), cytokeratin (CK), insulin, and glucagon. The chief cells were surrounded by S-100 protein-positive sustentacular cells (Fig. 2d).