PMC9381253_01
(a) Ulcerated and necrotic right nasolabial plaque with destruction of the right nasal wing on day 1 of the consultation. (b) Ulcerated and necrotic nasolabial plaque with significant loss of substance one month later after the first day of consultation.
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fig1
The lesion was infiltrated at the base with ulceration in its center and destruction of the right wing of the nose (Figure 1).
(a) Diffuse lymphoid infiltrate of the dermis and hypodermis epidermotropism, (b) diffuse lymphoid infiltrate of the dermis and hypodermis epidermotropism.
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fig2
The cells were of medium size with reduced cytoplasm and rounded or cleaved nuclei with 6 mitoses/10 HPF (Figure 2).
Immunohistochemistry had shown a lymphoid infiltrate expressing (a) CD3 +: positive, (b) CD8 + positive, and (c) KI67: proliferative index estimated at 50%.
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fig3
Ki67, a proliferative index, was estimated at 50% (Figure 3).
Complete healing of the lesion three months after the last chemotherapy treatment.
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fig4
After three doses of multidrug therapy, the lesion was completely healed (Figure 4).