PMC9215205_01
Here is reported the timeline of poziotinib administration and the related toxicities.
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In  Figure 1 , the timeline of poziotinib administration with the resulting side effects is reported.
CT scans performed on January 2021 [(A), baseline poziotinib] and subsequently on March 2021 (B) and October 2021 (C) demonstrated a PR (B) and a disappearance of the lesion (C).
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Then, in October 2021, CT scan confirmed a CR (reduction on tumour size of 100%) on both the liver and the retroperitoneal nodes ( Figure 2 ).
This figure demonstrated the exact lesions selected as target lesion for central and local radiological review.
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The graphics showed the local (A) and the central review (B) of the RECIS 1.1 criteria.
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