PMC4080671_01
(a) T1 contrast showing homogenously hypointense lesion with minimal patchy enhancement in cerebellum (b) T2 fluid attenuated inversion recovery showing homogenously hypertintense lesion in cerebellum
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F1
Magnetic resonance imaging-brain showed - An ill- marginated infiltrating mass lesion in postero-superior cerebellar hemisphere with extension across the midline to involve left cerebellar hemisphere, compressing and displacing the 4th ventricle [Figure 1].
Photomicrographs of the tumor showing moderate cellularity in a fibrillary background (a, H and E, x200). The tumor cells show moderate nuclear pleomorphism, frequent mitoses (arrow) (b, H and E, x400), immunopositivity for glial fibrillary acidic protein (c, immunohistochemical [IHC]; x400) and high MIB-1 labeling index (d, IHC; x400)
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F2
Histopathology examination showed a moderately cellular tumor with a fibrillary background infiltrating into the cerebellar parenchyma [Figure 2a]. The tumor cells displayed moderate nuclear pleomorphism and frequent mitotic figures, including atypical forms [Figure 2b]. Tumor cells were immunopositve for glial fibrillary acidic protein [Figure 2c] and p53. MIB-1 labeling index was approximately 25% in the highest proliferating areas [Figure 2d].