PMC4318070_01
Distant (a) and closer (b) views of pilar leiomyoma of the nasal dorsum presenting as an erythematous dermal nodule on the bridge of the nose
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F1
A healthy 24-year-old female patient presented with a 5 mm x 7 mm red dermal nodule on the bridge of her nose [Figures 1 and 2].
Right (a), upward (b) and left (c) views of the pilar leiomyoma of the nose of a healthy 24-year-old woman
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F2
A healthy 24-year-old female patient presented with a 5 mm x 7 mm red dermal nodule on the bridge of her nose [Figures 1 and 2].
A low magnification view (a) of the biopsy specimen from the nasal dorsum shows a plaque-like proliferation of cells, which are present in the mid and deep reticular dermis. Closer view (b) abundant mucin between the bundles of cells. The high magnification view (c) the cells have blunt-tipped, cigar-shaped nuclei without atypia or mitoses. These findings are suggestive of a pilar leiomyoma (H and E, a = x2, b = x4, c = x20)
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F3
A 2 mm punch biopsy revealed smooth muscle bundles forming a plaque in the dermis [Figure 3].
The tumor cells in the dermis express smooth muscle actin (a) The individual cells strongly stain positive (b) confirming the diagnosis of a pilar leiomyoma (smooth muscle actin immunoperoxidase staining using DAB, a = x4, b = x20)
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F4
The bundles of tissue were separated by abundant mucin and immunoperoxidase staining confirmed the presence of smooth muscle actin (SMA) [Figure 4].