PMC3133008_01
Case 1. A 52-year-old man with very severe fibrovascular proliferation throughout the posterior pole (A). In the retro-mode image, neovascular vessels in the fibrovascular membrane were clearly observed (B). Three days after intravitreal bevacizumab (IVB), most new vessels had regressed in the significantly contracted fibrovascular membrane (C). Neovascular vessel structures were still clearly observed in the retro-mode image after IVB (D). Arrows and arrowheads indicate the same neovascular vessels across images.
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f1-opth-5-897
Fundus examination disclosed very severe fibrovascular proliferation throughout the posterior pole (Figure 1A). However, the outline of the fibrovascular membrane itself was not clear (Figure 1B). Three days after 1.25 mg of IVB, fundus examination disclosed regression of most of the new vessels in the significantly contracted fibrovascular membrane, consistent with previous reports (Figure 1C). Surprisingly, most neovascular vessel structures in the fibrovascular membrane were still clearly observed in the retro-mode image (Figure 1D).
PMC3133008_02
Case 2. A 39-year-old man with severe fibrovascular proliferation around the optic nerve head (A). Neovascular vessels in the fibrovascular membrane were clearly observed in the retro-mode image (B). Two days after intravitreal bevacizumab (IVB), most of the new vessels had regressed. However, in the retro-mode imaging, neovascular vessel structures were still observed (C). Arrows and arrowheads indicate same neovascular vessels in the different images. Staining of the neovascular tissue from this case with hematoxylin-eosin disclosed that many neovascular capillaries were still present (arrowheads), but that only large vessels contained red blood cells (arrows) (D).
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Fundus examination disclosed severe fibrovascular proliferation around the optic nerve head (Figure 2A). Similarly to Case 1, neovascular vessels were clearly observed in the fibrovascular membrane with the retro-mode imaging function of the F10 SLO (Figure 2B). However, in the retro-mode image, neovascular vessels were still observed in the fibrovascular membrane (Figure 2C). Staining of the neovascular tissue with hematoxylin-eosin disclosed that many neovascular capillaries were still present, but that only large vessels contained red blood cells (Figure 2D).