PMC4300352_01
Contrast enhanced axial (A, B), coronal (C), and sagittal (D) computerised tomography scan demonstrates the presence of a giant mass distending the abdomen and pelvis. Heterogeneously enhancing (black arrows in B) lesion placed anterior to the mesenteric vessels (arrows). Coronal image demonstrates the bowel loop (straddling sign) (arrows in C) and mesenteric fat (arrowhead in A) over the mass. Anterior compression of the renal veins and inferior vena cava (arrows in A, arrowheads in B, and arrows in D)
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There was a minimal amount of ascites in the Douglas' space (Figure 1).
Macroscopic view of liposarcoma
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The excised mass was approximately 40 cm wide, weighed 7000 g, was greyish-brown, and had a fairly smooth surface and a lobule appearance (Figures 2A, B).
A - Diffuse S-100 positivity in the tumour (immunoperoxidase stain, 200x). B - Spindle-ovoid shaped atypical cells within a myxoid stroma (H + E stain, 200x). C - Ki-67 staining (arrows) in the tumour (immunoperoxidase stain, 200x)
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In histopathological examination, small "spindle-like/ovoid" and sometimes star-like shaped small atypical cells, which were stained positive with vimentin and S-100 in immunohistochemical staining (Figure 3A), showed no immunoreactions with CD117 and Desmin, resembling the histomorphology of angiomyxoma in some focuses. Widespread myxoid changes were observed (Figure 3B). The tumour cells exhibited an intermediate level of atypicality, and Ki-67 proliferation index was evaluated as 3-4% (Figure 3C).