PMC1797843_01
RNFL thickness in each quadrant of the eye, as measured by optical coherence tomography. (A) Right eye. (B) Left eye. Solid lines refer to the patient's eyes at 9, 10, or 15 months of follow-up; dashed and dotted lines refer to historical groups of healthy subjects (control) and of patients in an advanced stage of LHON with atrophy of the optic nerve.
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Figure 1 shows the retinal nerve fiber layer (RNFL) thickness in each quadrant, as measured by optical coherence tomography, for each of the patient's eyes after 9, 10, and 15 months, alongside values for historical groups of healthy subjects and of patients in an advanced stage of LHON (with atrophy of the optic nerve).
Three-generation reconstruction of the patient's maternal line. mtDNA analysis of the patient and his mother and siblings (asterisks) revealed the homoplasmic 11778/ND4 LHON mutation in all four of them; however, the patient was the only family member affected.
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No history of occupational or environmental exposure to solvents (or other particular toxic substances) was reported for any of the family members tested (Figure 2).