PMC6343154_01
Histologic sections of the duodenal major papilla tumor biopsy. (a) Hematoxylin and eosin, 10x amplification. (b) Hematoxylin and eosin, 40x amplification. (c) GATA-3 (IHC), 40x amplification. (d) ER (IHC), 40x amplification. (e) PR (IHC), 40x amplification. (f) HER2 (IHC), 40x amplification. Isolated tumor cells and tumor cells clustered in solid pattern were seen in the lamina propria of the duodenal mucosa. The tumor cells have pleomorphic nuclei with prominent nucleoli. IHC profiling was weakly positive for GATA-3 (c), strongly positive for HER2 (f), and negative for ER (d) and PR (e).
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fig1
Forceps biopsy from the major duodenal papilla was consistent with poorly differentiated adenocarcinoma (Figures 1(a) and 1(b)), of which histopathologic features showed no overt similarity to those of the prior mastectomy specimen. T-cell-specific transcription factor GATA-3 (Figure 1(c)) and negative for cytokeratin20 (CK20), ER, PR, and gross cystic disease fluid protein-15 (GCDFP-15) (Figures 1(d)-1(f)).