PMC6552338_01
Erythematous, violaceous nodules and plaques (varying in size from 0.5 to 1.5 cm) on (a, b) hands and (c) knees/pretibial regions.
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Several regular, edematous, violaceous erythematous nodules and plaques, varying in size from 0.5 to 1.5 cm, with peripheral excoriations were noted on the volar and dorsal surfaces of both hands, including all fingers (Figure 1(a) and (b)). Similar lesions were visible on both knees, calves and pretibial regions (Figure 1(c)).
Diffuse, dense dermal inflammatory neutrophilic infiltrates with sparse lymphocytes and no evidence of vasculitis (hematoxylin-eosin stain; (a) x4, (b) x40).
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Histopathology of both punch biopsies of the left thigh showed diffuse, dense dermal inflammatory neutrophilic infiltrates with sparse lymphocytes (Figure 2(a) and (b)), pathognomonic for Sweet's syndrome.
Chronic, diffuse colitis with crypt abscesses (x4).
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This diagnosis was confirmed on histopathology of the colonic biopsy, which showed chronic, diffuse colitis with crypt abscesses (Figure 3).