PMC5733935_01
This glomerulus demonstrates accentuation of the lobular architecture with associated endocapillary hypercellularity and duplication of the glomerular basement membranes (Jones methenamine silver).
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fig1
Kidney biopsy showed cellular crescents involving up to 63% of the sampled glomeruli (Figure 4), which demonstrated a membranoproliferative pattern of injury with prominent accentuation of the lobular structure and duplication of the glomerular basement membranes (Figure 1).
There is granular mesangial and capillary wall immunofluorescence staining for the respective immunoglobulins and complement components that range from 1 to 2+ on a scale of 0-4+.
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fig2
On a 0-4+ scale, immunofluorescence microscopy demonstrated granular capillary wall and mesangial staining for C3 (2+), C4d (1-2+), C1q (1+), and IgG (1+ in a segmental distribution) (Figure 2).
Figure demonstrating arteriolar thrombotic microangiopathy.
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fig3
Additional findings of a thrombotic microangiopathic injury were observed in a hilar arteriole with a thrombus (Figure 3).
A cellular crescent fills Bowman space adjacent to this glomerulus with prominent endocapillary hypercellularity (Periodic acid-Schiff).
CRIN2017-7964015.004.jpg
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fig4
Kidney biopsy showed cellular crescents involving up to 63% of the sampled glomeruli (Figure 4), which demonstrated a membranoproliferative pattern of injury with prominent accentuation of the lobular structure and duplication of the glomerular basement membranes (Figure 1).