PMC6196920_01
Chest CT scan showing bilateral ground glass opacities and nodular densities.
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fig1
He had a computed tomography (CT) scan of the chest which showed bilateral ground glass opacities predominantly in the upper lobes with increased nodularity and small-volume mediastinal lymphadenopathy (Figure 1).
Atypical lymphocytes in the vessels (100x).
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fig2
Pathologic examination of the wedge resection of the lung showed expanded pulmonary interstitium by atypical, discohesive lymphoid cells within alveolar capillaries on routine hematoxylin and eosin staining (Figures 2 and 3).
Hematoxylin-eosin staining atypical lymphocytes in the capillaries (20x).
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fig3
Pathologic examination of the wedge resection of the lung showed expanded pulmonary interstitium by atypical, discohesive lymphoid cells within alveolar capillaries on routine hematoxylin and eosin staining (Figures 2 and 3).
Hematoxylin-eosin staining showing angiotropism of medium size vessel.
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fig4
These atypical lymphoid cells also demonstrated angiotropism/angioinvasion of the medium sized pulmonary vessels (Figure 4).
CD20 immunostaining showing intravascular atypical lymphoid cells.
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fig5
Immunohistochemical (IHC) staining (DAKO platform) showed that the atypical lymphoid cells were positive for CD20 (Figures 5 and 6), CD79A, Pax5, BCL2, MUM1, BCL6 (more than 30%), and CD10 (focal; less than 10%).
CD20 immunostain showing angiotropism of medium size vessels by atypical lymphoid cells.
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fig6
Immunohistochemical (IHC) staining (DAKO platform) showed that the atypical lymphoid cells were positive for CD20 (Figures 5 and 6), CD79A, Pax5, BCL2, MUM1, BCL6 (more than 30%), and CD10 (focal; less than 10%).