PMC6448097_01
Right anterior oral tongue lesion at initial presentation.
10.1177_1179554919838254-fig1.jpg
PMC6448097_01_10.1177_1179554919838254-fig1.jpg
fig1-1179554919838254
Physical examination revealed a 2.5-cm ulcerative lesion of the anterior right oral tongue with central necrosis, with palpable deep extension of abnormal tissue to the midline (Figure 1).
PET/CT imaging demonstrating a hypermetabolic lesion of the right anterior tongue (arrow). CT indicates computed tomography; PET, positron emission tomography.
10.1177_1179554919838254-fig2.jpg
PMC6448097_01_10.1177_1179554919838254-fig2.jpg
fig2-1179554919838254
A positron emission tomography (PET)/computed tomography (CT) scan was performed confirming the right tongue lesion (Figure 2), and mildly hypermetabolic right level II nodes were visualized.
H&E stain of right anterior oral tongue mass demonstrating mitotically active infiltrating nests of epithelioid cells (arrows).
10.1177_1179554919838254-fig3.jpg
PMC6448097_01_10.1177_1179554919838254-fig3.jpg
fig3-1179554919838254
These cells demonstrated a high degree of cellular atypia with eccentrically placed nuclei with prominent nucleoli and dense pink cytoplasm (Figure 3), which combined with the infiltrative growth pattern confirmed a malignant tumor.
Immunohistochemistry demonstrating positivity for pancytokeratin (arrows).
10.1177_1179554919838254-fig4.jpg
PMC6448097_01_10.1177_1179554919838254-fig4.jpg
fig4-1179554919838254
Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
Immunohistochemistry demonstrating positivity for epithelial membrane antigen (EMA).
10.1177_1179554919838254-fig5.jpg
PMC6448097_01_10.1177_1179554919838254-fig5.jpg
fig5-1179554919838254
Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
Immunohistochemistry demonstrating positivity for calponin (arrows).
10.1177_1179554919838254-fig6.jpg
PMC6448097_01_10.1177_1179554919838254-fig6.jpg
fig6-1179554919838254
Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
Immunohistochemistry demonstrating positivity for glial fibrillary acidic protein (arrows).
10.1177_1179554919838254-fig7.jpg
PMC6448097_01_10.1177_1179554919838254-fig7.jpg
fig7-1179554919838254
Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
Three-month postoperative photograph demonstrating well-healed surgical site and no evidence of residual disease at primary site.
10.1177_1179554919838254-fig8.jpg
PMC6448097_01_10.1177_1179554919838254-fig8.jpg
fig8-1179554919838254
Physical examination and indirect flexible nasopharyngolaryngoscopy were normal, with a well-healed surgical defect (Figure 8).