PMC5379814_01
(a) Contrast enhanced computed tomogram head showing a well-defined hyperdense intraventriuclar lesion. (b-d) MRI axial images showing well-defined T1 hypo, T2 hyperintense lesion occupying the body of both lateral ventricles well enhancing with central hypointensity and another ill-defined lesion in the right frontal lobe. (e) Sagittal MRI showing the lesion pushing the body corpus callosum superiorly. (f) FLAIR coronal image showing hyperintense lesion. (g) Postoperative Non contrast computed tomogram showing total excision
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F1
T1 hypointense, T2 hyperintense intraventricular lesion filling the bilateral lateral ventricle with avid contrast uptake and central non-enhancing area [Figure 1a-e]. There was a non-enhancing area in the right frontal lobe contiguous with the intraventricular lesion as apparent on T2 and FLAIR images [Figure 1f].
(a) Photomicrograph of the tumor showing distinctly two populations of cells, one of a high-grade glial cell types showing marked nuclear pleomorphism and multinucleated tumor giant cells merging with bundles of malignant spindle-shaped cells (H and E, x250). (b) Photomicrograph showing selective cells stained positive for glial fibrillary acidic protein (PAP, x450). (c) Photomicrograph showing vimentin positivity by both types of tumor cells i.e., spindle-shaped cells and malignant glial cells with bizarre nuclei (PAP, x450)
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F2
Tumor cells showed immunoreactivity for glial fibrillary acidic protein (GFAP) and vimentin [Figure 2a-c].