PMC4935008_01
Cervical lymph node biopsy.. Notes: (A) Lymph node with geographic necrosis surrounded by histiocytes (hematoxylin-eosin stain, x10 magnification). (B) Geographic necrosis and cellular detritus without the presence of polymorphonuclear neutrophils or histiocytes (hematoxylin-eosin stain, x40 magnification). (C and D) Positive immunostaining in histiocytes with CD68 (hematoxylin-eosin stain, x10 and x40 magnifications). (E) Immunostaining with CD20 antibody (hematoxylin-eosin stain, x10 magnification). (F) Negative immunostaining with CD1a antibody (hematoxylin-eosin stain, x40 magnification).
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Owing to the nonspecific findings of the first lymph node sampling, it was decided to perform a second biopsy guided by ultrasound to select tissue with less necrosis (Figure 1).