PMC8570448_01
Organs from stillborn child with COVID-19 show viral infiltration. (A) H&E stained lung section showing lymphocytic infiltration (red) and proliferation of epithelial cells. 100x magnification. (B) H&E stained pancreas section showing lymphocytic infiltration (red). Islets are indicated in black. 100x magnification. (C) H&E stained sections demonstrating cellular changes in an endocrine pancreatic islet. 400x magnification. (D) Coronavirus spike proteins in the islets detected by immunohistochemistry (brown). 400x magnification.
gr1.jpg
PMC8570448_01_gr1.jpg
fig0005
Proliferative changes in the lungs as observed in adults infected with SARS-CoV-2 were noticed, but without signs of ARDS (Fig. 1A). Nodular hyperplasia in the adrenal cortex was detected and mononuclear infiltration and cellular changes were documented in liver and kidney and more pronounced in the pancreas (Fig. 1B,C) as found in adult COVID-19 patients. Virus antigen was detected in brain, kidney, heart, spleen, adrenal, and pancreas (Fig. 1D).