PMC5771736_01
A, Numerous subcutaneous nodules present on the right thigh, which were also present on the left thigh. B, Atrophic scars after numerous subcutaneous nodule excisions on the right thigh.
gr1.jpg
PMC5771736_01_gr1.jpg
fig1
The patient has since had around 10 and 14 nodules surgically removed from the left and right leg, respectively, which has improved his pain yet has left significant atrophic scars (Fig 1, B).
A, Necrotizing granulomatous inflammation. Peripheral fibrosis and fat necrosis with granulomatous reaction is also seen. B, At higher magnification, a histiocytic infiltrate with multinucleated giant cells surrounding necrosis with calcification is present. (A and B, Hematoxylin-eosin stain; original magnifications: A, x20; B, x100).
gr2.jpg
PMC5771736_01_gr2.jpg
fig2
A right thigh nodule biopsy found fibroconnective tissue with dense fibrosis, granulomatous inflammation, fat necrosis, and calcification on histology (Fig 2, A and B).
PMC5771736_02
Numerous subcutaneous nodules present on the right shoulder, which were also present on the left shoulder.
gr3.jpg
PMC5771736_02_gr3.jpg
fig3
One month after completion of her trial in August 2012, the patient noted around ten 1- to 2-cm subcutaneous nodules on each of her upper arms at her immunotherapy injection sites (Fig 3).
PMC5771736_03