PMC3914222_01
Glomeruli from the renal biopsy. (a) Cellular destructive crescent with discontinuities in Bowman's capsule (arrow). The adjacent interstitium had edema and a mononuclear leukocytic infiltrate. Periodic acid-Schiff x250. (b) Immunofluorescence showing strong (3-4+) linear IgG staining along capillary walls. The capillary walls are disrupted focally due to crescent formation x250. (c) Broken glomerular capillary wall (arrow) associated with a cellular crescent. There are no capillary wall electron dense deposits x10,000.
CRIM.NEPHROLOGY2012-132085.001.jpg
PMC3914222_01_CRIM.NEPHROLOGY2012-132085.001.jpg
fig1
Eight glomeruli had crescents, all in an active stage (Figure 1(a)). Immunofluorescence was performed on 14 glomeruli, all of which had strong linear capillary wall staining for IgG with lesser staining for kappa and lambda light chains (Figure 1(b)). Ultrastructural study was performed on three glomeruli and confirmed disruptions of capillary and Bowman's capsular basement membranes (Figure 1(c)).