PMC6489092_01
Trends of Hb and Ferritin in time with respect to cycles and IL-10 dosing. Relationship between levels of Hb, and Ferritin over time in relation to RBC infusion and IL-10 dosing.
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F1
Hb levels at the end of cycle 2 (6/13/2018) revealed no change in Hb (Fig. 1). However, by the end of the 3rd cycle of therapy (6/30/2018), the patient experienced a grade III anemia with a hemoglobin drop to 6.6 g/dL with no evidence of bleeding or hemolysis.
PET-CT scan images for Patient #01 prior (A) and 4 months following (B) treatment with Nivolumab + AM0010.
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F2
Four months following treatment initiation (9/4/2018), PET-CT scan revealed marked reduction in SUV from 11.2 to below pathogenic level, 2.7 in the RUL and no evidence in tumor activity in the adrenal glands (Fig. 2).