PMC6714328_01
Histopathological findings in a kidney biopsy specimen showing collapse of capillary loop and segmental sclerosis with proliferation of glomerular epithelial cells. (a) Hematoxylin-eosin staining, high magnification. Intraluminal cell proliferation or necrotizing crescentic formation is not shown. (b) Periodic acid-Schiff staining, high magnification. Mesangial matrix proliferation or mesangial cell proliferation is not shown. (c) Periodic acid-methenamine-silver staining, low magnification. (d) Periodic acid-methenamine-silver staining, high magnification. A segmental lesion is observed at the tubular pole. (e) Periodic acid-methenamine-silver staining, low magnification. (f) Periodic acid-Schiff staining. Although there was slight lymphocytic infiltration in the tubulointerstitial area, obvious tubulointerstitial nephritis was not detected.
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fig1
TIN were not detected in the specimens (Figure 1). There was one glomerulus in the immunofluorescence specimen.
Patient's clinical course. The patient was treated with PSL and CyA. The urine protein/urine creatinine ratio gradually decreased until complete remission (urine protein excretion <0.3 g/gCr) was achieved. CyA: cyclosporine; PSL: prednisolone.
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fig2
The urinary protein/urinary creatinine ratio was 0.09 g/g Cr, her serum albumin level increased to 3.7 g/dL, and her leg edema disappeared (Figure 2).