PMC6262786_01
(a) Computed tomography of the chest showing a lung nodule measuring 12 x 10 mm in the right basal segment (arrow). (b) Computed tomography one year prior showing a lung nodule measuring 7 x 6 mm (arrow). (c) Positron emission tomography showing no uptake of 18-fluorodeoxyglucose into the lung nodule.
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The chest CT revealed a solitary pulmonary nodule measuring 12 x 10 mm with a clear margin in the right lower lobe that had grown from 7 x 6 mm at the time of the initial diagnosis of the tongue cancer one year prior (Fig. 1a, b). There was no uptake on the 18-fluorodeoxyglucose positron emission tomography (18-FDG-PET) (Fig. 1c).
(a) Histologically the tongue lesion shows an invasive squamous cell carcinoma with dyskeratosis (hematoxylin and eosin, X150). (b) Histologically the right lung nodule exhibits tubular and cribriform patterns containing an amorphous eosinophilic material (hematoxylin and eosin, X150).
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It was a typical finding of an ACC which was different from the histology of the tongue SqCC one year prior (Fig. 2a, b).
Histologically both a gingival cancer from 36 years prior (a) and a cervical metastasis 31 years prior (b) revealed tubular and cribriform patterns with amorphous eosinophilic material (hematoxylin and eosin, X150).
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We retrospectively reviewed the histology of the gingival cancer resected 36 years previously, which revealed a cribriform pattern just the same as that of the lung nodule (Fig. 3a). A metastatic lymph node, dissected 31 years previously also revealed the same histology as the ACC (Fig. 3b).