PMC5286473_01
PET CT before treatment. Stage II bulky Hodgkin lymphoma.
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Positron-emission tomography (PET) CT scan showed numerous lymphadenopathy lesions (axillary, pectoral) with a standard uptake value (SUV) max of 10.1 (Figure 1).
Follicle bulb onion, typical of Castleman disease. Stained section of lymph node biopsy, x100 magnification, HES coloration.
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A new anatomopathologic analysis led to the conclusion that a focal plasma cell variant of Castleman disease (Figures 2 and 3) coexisted in the same interfollicular area as CD30+ HL lesion (Figures 4, 5, and 6).
Plasmacytic cells labeled with MUM1 antibody. Section of lymph node biopsy, x400 magnification.
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A new anatomopathologic analysis led to the conclusion that a focal plasma cell variant of Castleman disease (Figures 2 and 3) coexisted in the same interfollicular area as CD30+ HL lesion (Figures 4, 5, and 6).
Plasmacytic cell and Hodgkin cell lymphoma. Section of lymph node biopsy, x100 magnification.
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A new anatomopathologic analysis led to the conclusion that a focal plasma cell variant of Castleman disease (Figures 2 and 3) coexisted in the same interfollicular area as CD30+ HL lesion (Figures 4, 5, and 6).
Hodgkin cells stained with anti-CD30 antibodies. Section of lymph node biopsy, x400 magnification.
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fig5
A new anatomopathologic analysis led to the conclusion that a focal plasma cell variant of Castleman disease (Figures 2 and 3) coexisted in the same interfollicular area as CD30+ HL lesion (Figures 4, 5, and 6).
Hodgkin cells. Section of lymph node biopsy, x400 magnification.
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A new anatomopathologic analysis led to the conclusion that a focal plasma cell variant of Castleman disease (Figures 2 and 3) coexisted in the same interfollicular area as CD30+ HL lesion (Figures 4, 5, and 6).
PET CT after treatment.
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The patient achieved complete remission, according to the Cheson criteria, assessed with PET CT, after 2 and 4 curative treatments (Figure 7).