PMC6005304_01
Hematoxylin and eosin stain of intraocular hemangiosarcoma demonstrating neoplastic spindle cells lining blood-filled vascular channels. Arrows indicate neoplastic cells lining vascular, blood-filled channels.
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fig1
The presence of atypical fusiform cells, carpeting the posterior aspect of the iris and ciliary body surface, dissecting the hemorrhage in the posterior chamber, and forming vascular channels, was deemed to be suggestive of metastatic hemangiosarcoma to the eye (Figure 1).
Hematoxylin and eosin stain of splenic hemangiosarcoma. Neoplasm consists of erratic streams of neoplastic, endothelial-like, fusiform cells forming the linings of tortuous blood-filled channels and cavities supported by fibrous stroma.
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fig2
The growth comprised erratic streams of neoplastic, endothelial-like, fusiform cells forming the linings of tortuous blood-filled channels and cavities supported by fibrous stroma (Figure 2).
Positive immunohistochemical staining of the splenic tumor for CD31. Brown color indicates positive staining of neoplastic cells immunoreactive with a monoclonal mouse anti-human CD31 antibody.
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fig3
As can be seen in Figure 3, the neoplastic cells were immunoreactive for CD31 antibody.