PMC3843903_01
Submandibular mass biopsy revealing florid follicular hyperplasia along with eosinophilic cell infiltration, focal fibrosis and giant cell reaction.
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F1
The patient underwent biopsy of the submandibular mass that revealed features of Castleman's disease (fig. 1).
Liver biopsy revealing perisinusoidal deposition of eosinophilic, amorphous material within the extracellular matrix with hepatocyte atrophy, consistent with hepatic amyloidosis.
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F2
A subsequent liver biopsy revealed perisinusoidal deposition of eosinophilic, amorphous material within the extracellular matrix with hepatocyte atrophy, consistent with hepatic amyloidosis (fig. 2).
Bone marrow biopsy revealing diffuse extracellular eosinophilic, amorphous material consistent with amyloidosis.
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F3
Bone marrow biopsy revealed diffuse extracellular eosinophilic, amorphous material consistent with amyloidosis with increased kappa light chain-restricted plasma cell count (6% of hematopoietic bone marrow cells) (fig. 3).