PMC10035544_01
a Clinical aspect of the PAM at the beginning. b Evolution of the diffuse PAM after 10 weeks of topical INF alpha 2b. c Histological study, C-MIN 5 Hematoxylin Eosin, x10. d Clinical resolution after 2 months of cryotherapy.
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F1
A 64-year-old Caucasian female presented with diffuse pigmentation of the right eye involving the inferior tarsal conjunctiva, fornix, and inferotemporal bulbar conjunctiva (Fig. 1a). This was well-tolerated; however, after 10 weeks, lesional regression was very slow (Fig. 1b). We performed three map biopsies in the areas of greatest pigmentation at the level of the fornix and the histological study showed a PAM with atypia (C-MIN 5) (Fig. 1c). This afforded progressive depigmentation, which was completed 2 months later (Fig. 1d).