PMC7568228_01
Hyperchromatic-crowded groups (a and b) adjacent to benign squamous cells (PAP, x40), (c) hyperchromatic-crowded group with intracytoplasmic mucin (PAP, x40), (d) The biopsy specimen showed cribriform/microacinar architecture with confluent neoplastic glands (H and E, x40).
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F1
The cells showed high nuclear-cytoplasmic ratios, hyperchromatic nuclei with coarse chromatin, nuclear membrane irregularities, ill-defined cell borders, and prominent nucleoli [Figure 1].
(a and b) Angulated, fragmented, infiltrative, and irregularly shaped glands with a conspicuous desmoplastic reaction (H and E, x4 and x10). (c and d) Malignant fused glands with cribriform architecture and a neutrophilic infiltrate (H and E, x10 and x40).
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F2
HCG. High-risk human papillomavirus (HPV) test was positive in this patient, and endocervical curettage with cervical biopsy revealed the findings shown in Figure 2.
Immunohistochemistry for p16, monoclonal carcinoembryonic antigen, estrogen receptor, and progesterone receptor.
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F3
The tumor cells showed nuclear immunoreactivity for p16 with monoclonal carcinoembryonic antigen (mCEA) immunoreactivity but nonimmunoreactivity for estrogen receptor (ER), progesterone receptor (PR), and vimentin [Figure 3].