PMC4873689_01
H&E staining showing hypercellular stroma with absence of atypia or mitosis.
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PMC4873689_01_gr1.jpg
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The mitotic index was very low (2 x 10 hpf), and no necrosis, atypia or pleomorphism was seen (Fig. 1, Fig. 2).
H&E staining showing leaf-like structure in a monomorphic background.
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PMC4873689_01_gr2.jpg
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The intraductal epithelial proliferation was arranged in a cribriform and solid pattern of growth; the tumour itself showed foci of comedo-type necrosis, pleomorphism and mitotic activity with nuclear hyperchromasia (Fig. 2).
H&E. staining showing DCIS with comedo necrosis.
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PMC4873689_01_gr3.jpg
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Overall, the histopathological features were compatible with a biphasic tumour consisting of a benign phyllodes tumour with foci of high-grade DCIS without an invasive component (Fig. 3) and appeared to be excised with narrow margins.