PMC6375020_01
(a) Section showing the presence of bile pigment within tubular epithelial cells (white arrow) and rigid cast in one of the tubules with surrounding interstitial inflammation (H and E, x400). (b) Section showing numerous tubules containing PAS negative-fractured casts, interstitial inflammation, interstitial fibrosis, and tubular atrophy along with two normal glomeruli (PAS, x200). (c) Section showing characteristic giant cell reaction to myeloma casts (H and E, x400). (d) Section showing negative Prussian blue reaction in bile pigment (Perl's stain x 400, black arrow)
IJN-29-50-g001.jpg
PMC6375020_01_IJN-29-50-g001.jpg
F1
Interstitial fibrosis tubular atrophy was about 40%, and mild patchy interstitial edema and lymphocytic infiltrate were noted [Figure 1a-d].
(a and b) Photomicrographs of direct immunofluorescence showing kappa restriction (FITC, x400)
IJN-29-50-g002.jpg
PMC6375020_01_IJN-29-50-g002.jpg
F2
No glomerular or tubular basement membrane positivity was noted [Figure 2a and b].