PMC5795733_01
Case 1. (a) Solitary yellowish-white nodule over the scalp measuring 1 cm in diameter; (b) Fine needle aspiration (FNA) smear showing cluster of cells with vacuolated cytoplasm and bland nuclei intermingled with basaloid cells (Wright Geimsa stain, x400); (c) FNA smear showing clusters with a mixture of basaloid and vacuolated cells along with eosinophilic stroma (Wright Geimsa stain, x100); (d) Section from the the excised tumor demonstrating amalgamation of vacuolated and basaloid cells (H and E, x400)
JCytol-35-60-g001.jpg
PMC5795733_01_JCytol-35-60-g001.jpg
F1
A 46-year-old female presented with a nontender, nonmobile, elevated firm, yellow-colored nodule measuring 1 x 1 cm over the scalp [Figure 1a]. The other population was of basaloid cells [Figure 1b]. Few clusters showed a mixture of these two populations along with eosinophilic stroma [Figure 1c]. The tumor comprised of irregularly-shaped lobules with two types of cells, small round-to-oval basaloid cells admixed with larger cells having round vesicular nuclei and moderate foamy cytoplasm [Figure 1d].
PMC5795733_02
Case 2. (a) Solitary nodule over the scalp with blackish discoloration measuring 1.5 cm in diameter; (b) Fine needle aspiration (FNA) smear showing tight cluster of cuboidal cells with cytoplasmic granularity (Wright Geimsa stain, x400); (c) FNA smear showing cluster of cuboidal cells and few pigment-laden macrophages (Wright Geimsa stain, x200); (d) Section from excised tumor composed of broad anastomosing bands of epithelial cells intermingled with cells showing intracytoplasmic melanin pigment (H and E, x100)
JCytol-35-60-g002.jpg
PMC5795733_02_JCytol-35-60-g002.jpg
F2
A 19-year-old male presented with an asymptomatic pigmented scalp swelling measuring 1.5 x 1.5 cm [Figure 2a]. FNAC smears revealed tight clusters and dispersed small polyhedral to cuboidal cells with cytoplasmic granularity [Figure 2b]. Many cells with cytoplasmic brown black pigment were seen along with specks of calcification[ Figure 2c]. Sections revealed a tumor arising from the epidermis extending into the dermis as broad anastomosing bands of uniform, cuboidal tumor cells with indistinct cell borders, round-to-oval basophilic nucleus, and few showing intracytoplasmic melanin pigment [Figure 2d].