PMC9938452_01
A. Parotis gland involved by follicular lymphoma composed of homogeneus nodules (H&E,X40) B. Tumor cells of follicular lymphoma showed positivity for immunohistochemistry of CD20 (CD20/peroxidase stain,X40) C. Bcl-2 (Bcl-2/peroxidase stain,X40) D. CD10 (CD10/peroxidase stain,X40).
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The morphology of the specimen showed complete architectural effacement by a nodular lymphoid proliferation of small lymphocytes with elongated and cleaved nuclei (Figure 1A) in addition to a well defined nodule 4 mm in diameter. The tumor cells in the regions with follicular structure showed positivity for CD20 (Figure 1B), BCL2 (Figure 1C), and CD10 (Figure 1D), and negativity for cyclin D1 and SOX11.
A. Follicular lymphoma with a small focus of Langerhans cell histiocytosis B. Tumor cells of Langerhans cell histiocytosis showed positivity for immunohistiochemistry of CD1a (CD1a/peroxidase stain,X100) C. S-100 (S-100/peroxidase stain,X100).
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Regions with acidophilic cytoplasm, pale clefted nuclei, inconspicous nucleoli, and large atypical cells showed easily detectable nuclear bodies (Figure 2A). The tumor cells in the regions without follicular structure showed positivity for CD1a (Figure 2B), and S-100 (Figure 2C), and negativity for CD163, confirming LCH.
Follicular lymphoma and Langerhans cell histiocytosis shown within the same tissue (H&E, X40).
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Both FL and LCH within the same tissue was shown on Figure 3 (H&E, x40).