PMC4448067_01
Motor neurones in the spinal cord (a, ai, b, bi) and hypoglossal nucleus (c) of case 1. Immunohistochemistry for TDP-43 (a, ai, c) and p62 (b, bi). Physiological intranuclear TDP-43 staining (arrowhead in a) and pathological aggregations of phosphorylated TDP-43 (arrows in c) are seen, with strong intracytoplasmic extranuclear positivity for TDP-43 (ai) and p62 (bi). Original magnification: x400 (a, b), x600 (c); scale bars: 50 mum (a, b), 20 mum (c).
crn-0007-0095-g01.jpg
PMC4448067_01_crn-0007-0095-g01.jpg
F1
Some of the remaining spinal cord motor neurones displayed characteristic intracytoplasmic extranuclear inclusions that stained positive for TDP-43 (fig. 1a) as well as for p62 antibodies (fig. 1b); TDP-43 inclusions were also seen in hypoglossal nucleus motor neurones (fig. 1c).
PMC4448067_02
PMC4448067_03