PMC5437439_01
CT of the abdomen using pancreatic protocol.
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F1
The initial diagnosis was unclear and the patient underwent computed tomography (CT) of the abdomen for further evaluation (Fig. 1).
EUS image of the pancreas with squamous cell carcinoma.
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F2
For further evaluation, endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) was performed (Fig. 2).
The neoplasm is composed of many malignant cells with round to oval nuclei (HE). a Sheets of malignant cells with round to oval nuclei with thick nuclear membrane. b Prominent nucleoli and high N/C ratio cytoplasm which are eosinophilic granular and moderate to abundant with rather well-defined borders.
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F3
FNA samples from the pancreas were sent for pathological examination (Fig. 3).
The CEA marker (a) is negative, the CK5/6 (b) and P63 (c) markers are positive.
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F4
The immunohistochemical studies (Fig. 4) were performed using antihuman antibodies against the following markers: unlike CEA, which was negative in tumor cells, CK5/6 and P63 were strongly positive in tumor cells.
Abdominal axial CT scan depicting a developed pancreatic SCC.
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F5
Four months after chemotherapy, clinical signs continued and abdominal CT was done again (Fig. 5).