PMC6756369_01
PET-CT and MRI results showed multiple masses located in the peritoneum and omentum.
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PET-CT indicated thickening of the peritoneum and omentum which is hypermetabolic with an SUVmax of 2.5 (Figure 1A). Abdominal MRI revealed that peritoneal and omental thickening with nodules, suggestive of malignant disease (Figures 1B and 2A).
MRI revealed tumour masses at different stages of the disease including (A) pretreatment (B) post-treatment and (C) recurrence.
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Abdominal MRI revealed that peritoneal and omental thickening with nodules, suggestive of malignant disease (Figures 1B and 2A). AFP declined sharply from 60,500 ng/mL to 450 ng/mL and with the complete regression of ascites (Figure 4). After 2 cycles, MRI revealed that all the pre-existing lesions were disappeared (Figure 2B). AFP level increased again to 22,312 ng/mL (Figure 2C). At the time, the liver function of the patient returned to a normal level.
(A) Hepatocellular carcinoma composed of cells exhibited an eosinophilic cytoplasm and enlarged and round nuclei (haematoxylin & eosin, stain 200) (B) The tumour cells were positive for alpha-fetoprotein (AFP) (AFP stain 100) (C) The tumour cells were positive for Arginase l (Arginase l stain 100) (D) The tumour cells were positive for CK8/18 (CK8/18 stain 100) (E) The tumour cells were positive for Glypican 3 (Glypican 3 stain 100) (F) The tumour cells were positive for CD34 (CD34 stain 100).
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The neoplastic cells were immunoreactive for Glypican 3, Arginase I, alpha-fetoprotein (AFP), CK8/18, and CD34, weakly positive for PCK, CK19, and CK7 and negative for EMA, hepatocytes, CK20, calretinin, and VIM (Figure 3A-F).
The chart shows the general trend of serum AFP at different stages of the treatment.. Abbreviations: XELOX, Oxaliplatin and Capecitabine, X: Capecitabine; S, Sorafenib; L, Lenvatinib.
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AFP declined sharply from 60,500 ng/mL to 450 ng/mL and with the complete regression of ascites (Figure 4). After 2 cycles, MRI revealed that all the pre-existing lesions were disappeared (Figure 2B).