PMC4896177_01
75-year-old woman with bilateral thigh pain. Radiographs of the right (A) and left (B) femora demonstrate extensive regions of soft tissue calcification (arrows) in the thighs.
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Radiographs (Figure 1) of both femora demonstrate masses of soft tissue calcification in the thighs without cortical erosion or mass effect.
75-year-old woman with bilateral thigh pain. Radiographs of the right (A) and left (B) humeri demonstrate extensive calcified soft tissue deposits (arrows).
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Radiographs of both humeri (Figure 2) also demonstrate large areas of calcification in the soft tissues without abnormality of the adjacent humeri.
75-year-old woman with bilateral thigh pain. Axial (A) and coronal (B) computed tomography of bilateral thighs shows that the calcified masses (arrows) within the quadriceps muscles are relatively symmetric and most extensive involving the distal thirds of the thighs.
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Computed tomography of the bilateral thighs (Figure 3) shows the calcifications are symmetric and most extensive in the distal thirds of the thighs.
75-year-old woman with bilateral thigh pain. Axial T1-weighted (A), coronal T1-weighted (B) and coronal inversion recovery (C) magnetic resonance images of the right knee show the mass-like area of calcification (arrows) in the vastus lateralis muscle. The mass has heterogeneous isointense to hypointense signal on T1 and homogeneous low signal on the inversion recovery sequence.
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Magnetic resonance imaging (Figure 4) of her right knee demonstrates a mass-like area of calcification in the vastus lateralis muscle, unchanged from the calcification seen on the previous radiographs.
75-year-old woman with bilateral thigh pain. Axial (A) and coronal (B) computed tomography of the bilateral thighs reveals the mass-like area of calcification (arrows) in the distal right vastus lateralis muscle had increased in size over the intervening two years (See Figure 3 for comparison).
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Computed tomography of the right thigh (Figure 5) reveals the mass-like area of calcification and soft tissue density in the distal right vastus lateralis muscle has increased in size and is significantly closer to the skin surface.
75-year-old woman with bilateral thigh pain. Histologic section (Hematoxylin-eosin; x100, x100, x40 respectively) photographs of the surgically excised mass shows (A) amorphous calcified material bordered by a few osteoclast-like giant cells (arrow) with a surrounding wall of fibrous tissue, (B) amorphous calcified material with surrounding fibrous tissue, and (C) the cystic fibrous-walled cavity beneath the skin.
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The surgical pathology revealed fibrous tissue and calcified debris (Figure 6).