PMC9932033_01
Hematoxylin and eosin-stained section of the nasal polyp (scale bar = 50 mum). Marked eosinophil infiltration in the subepithelial area is observed.
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F1
JESREC score and tissue eosinophil count in the nasal polyp at the first treatment was 17 and 107/hpf, respectively (Figure 1).
Images of nasal endoscopy and sinus CT before initiation of dupilumab therapy. (A) Nasal polyps occupying the common nasal meatus were observed. (B) Soft tissue density lesions were filling all sinuses on both sides. CT, computed tomography; INT, inferior nasal turbinate; NS, nasal septum.
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F2
On nasal endoscopy, nasal polyps occupying both sides of the common nasal meatus were observed, with a total polyp score (TPS) of 8 (Figure 2A). Computed tomography (CT) of the sinus revealed a soft tissue density lesion filling all sinuses on both sides, with a Lund-Mackay CT score (LMS) of 24 (Figure 2B).
Images of nasal endoscopy and sinus CT 6 months after the initiation of dupilumab therapy. (A) Nasal polyps occupying the common nasal meatus were still observed. (B) Soft tissue density filled all sinuses on both sides. CT, computed tomography; INT, inferior nasal turbinate; NS, nasal septum.
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F3
TPS of 6 (Figures 3A,B). The blood eosinophil percentage at that time was 11%.
Images of nasal endoscopy and sinus CT 1 month after the diagnosis of SARS-CoV-2 infection. (A) A marked reduction of nasal polyps was confirmed. (B) Soft tissue density lesions in the sinuses were markedly reduced. CT, computed tomography; INT, inferior nasal turbinate; NS, nasal septum; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
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F4
A marked reduction in nasal polyps was confirmed on nasal endoscopy, with a TPS of 3 (Figure 4A). Sinus CT also revealed a marked reduction in soft tissue density lesions of the paranasal sinuses, with an LMS of 12 (Figure 4B).