PMC9932035_01
CT image results in lung and abdomen of the patient. (A) CT image of lung infection with Talaromyces marneffei. (B) CT image of abdomen, lymphadenopathy in the retroperitoneum and mesenteric root, and hepatosplenomegaly, the largest of which is 31x25 mm (white arrow). (C) CT image of abdomen, lymphadenopathy in the retroperitoneum and mesenteric root, and hepatosplenomegaly are improved, the largest of which becomes normal (white arrow).
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CT on 17 March 2022 showed a little inflammation in the lower lobes of both lungs, lymphadenopathy in the retroperitoneum and mesenteric root, and hepatosplenomegaly ( Figures 1A, B ). After 7 months of follow-up, repeat abdominal CT showed resolution of the retroperitoneum and mesenteric root lymphadenopathy ( Figure 1C ), and no adverse events have been found.
Culture results of this patient. (A) Blood culture on Sabouraud's agar medium plate at 37 C showed yeast phase. (B) Blood culture of Talaromyces marneffei in the mold phase at 25 C, characteristic red pigment production was observed. (C) Lactophenol cotton blue staining from fungal blood culture demonstrating septate hyphae and smooth conidia aloft phialides, which are borne to metulae.
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The coverage of T. marneffei in blood and BALF detected by mNGS was 3.63% and 1.07%, respectively. The pathogen was subsequently confirmed by blood culture on 28 March 2022 ( Figures 2A-C ).
Important clinical information of the recipient and treatment timeline after renal transplantation.
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Important clinical information and treatment timelines for this patient during hospitalization are presented in  Figure 3 .