PMC3541771_01
Intraoral photo of the granular cell tumour affecting the dorsum of the tongue.
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fig1
The lump was tender to palpation and had an unusual hyperkeratotic surface (Figure 1).
Low power view of oral granular cell tumour stained with hematoxylin and eosin.
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fig2
An excisional biopsy was performed under local anaesthesia and the specimen submitted for histological analysis (Figures 2 and 3).
High power view of oral granular cell tumour stained with hematoxylin and eosin.
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fig3
An excisional biopsy was performed under local anaesthesia and the specimen submitted for histological analysis (Figures 2 and 3).
PMC3541771_02
Intraoral photo of the granular cell tumour affecting the buccal mucosa.
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fig4
Extraorally no pathology was detected intraorally the lesion presented as a thick, raised, white plaque, fixed to underlying tissues and measuring 6 mm in diameter (Figure 4). 
Immunoreactivity of the lesion for S-100 protein.
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fig5
The results of this confirmed the diagnosis of a granular cell tumour; the immunohistochemistry showed that the cells were positive for S-100, but negative for Melan A, MNF-116, and CD68, consistent with a granular cell tumour (Figure 5).