PMC4721013_01
H&E staining of malignant struma ovarii tissues. H&E staining (a) showed fibrous cores of tissue lined by neoplastic cells which contain large overlapping "ground-glass" nuclei characteristic of thyroid papillary carcinoma. b Metastasis to omentum is shown (H&E, original magnifications x400)
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Fig1
An intra-operative frozen and permanent paraffin section was proved to be a malignant struma ovarii with multiple foci of papillary thyroid carcinoma (Fig. 1a). The pathologic examination showed no metastatic neoplasm was found, except on the omentum material (Fig. 1b).
Immunohistochemical (CK19, galetin-3, HBME-1) staining of malignant struma ovarii tissues. a CK19 was diffuse and strong cytoplasmic staining in MSO. b MSO showing strong cytoplasmic staining of galectin-3. c MSO with beautiful complex papillae exhibits a HBME-1 membrane staining pattern (immunohistochemistry, original magnifications x400)
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Fig2
Immunohistochemically, tumor cells were strongly positive for thyroglobulin (Tg), thyroid transcription factor-1 (TTF-1), galetin-3, cytokeratin-19 (CK19), and human bone marrow endothelial cell-1 (HBME-1) (Fig. 2).
PMC4721013_02