PMC9938395_01
11-mm semi-pedunculated polyp in the ascending colon (black arrow).
crg-2022-0017-0001-529170_f1.jpg
PMC9938395_01_crg-2022-0017-0001-529170_f1.jpg
F1
It was hard, isolated gray-white submucosal lesion with normal overlying mucosa (shown in Fig. 1).
The morphology of granular cell tumor in intramucosal and focally submucosal location in a colon polyp (H&E. x10). Infiltrative growth pattern with nested or trabecular cellular clusters or sheets are appreciated. The cells are with abundant amphophilic granular cytoplasm and centrally or eccentrically located small round or irregularly shaped nuclei. No necrosis or mitosis is appreciated.
crg-2022-0017-0001-529170_f2.jpg
PMC9938395_01_crg-2022-0017-0001-529170_f2.jpg
F2
Histopathologic examination of the resected polyp showed an intramucosal and submucosal tumor composed of polygonal cells with abundant amphophilic granular cytoplasm and centrally or eccentrically located small round or irregularly shaped nuclei (shown in Fig. 2).
S100 positive staining highlighted the infiltrating trabecular growth pattern of this granular cell tumor (H&E. x10).
crg-2022-0017-0001-529170_f3.jpg
PMC9938395_01_crg-2022-0017-0001-529170_f3.jpg
F3
Immunohistochemical analysis showed tumor cells were positive for S-100 (shown in Fig. 3), CD68, and inhibin and negative for CD117 and neurofilament.