PMC8100182_01
PMC8100182_02
High resolution chest CT showing diffuse thickening of the interlobular septae (white arrows) in the right lung.
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F1
A high resolution chest CT revealed diffuse, extensive thickening of the interlobular septae on the right leading to a suspicion for unilateral lymphangiectasia (Figure 1).
Wedge resection of right lower lobe. (A) Hematoxylin-Eosin stain showing thickened pleura and septum containing increased number of markedly dilated lymphatic channels. (B) Trichrome stain showing fibrosis (blue) in the pleura and septum. (C) Immunostain staining nuclei red confirming lymphatic origin of endothelium of dilated pleural and septal vessels.
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F2
The patient underwent a thoracoscopic lung biopsy at the age of 2 which identified pleural and septal fibrosis with dilated lymphatics consistent with pulmonary lymphangiectasia (Figure 2).
PMC8100182_03