PMC3905963_01
MRI of pediatric glioma. (A) MRI shows a large right thalamic tumor compressing the third ventricle. (B) MRI control 9 months later.
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F1
Diffusion-tensor imaging was conducted to locate the posterior limb of the internal capsule (PLIC) in the preoperative MR (Figure  1A). An MR image obtained 9 months later revealed no tumor recurrence, and the patient remained neurologically intact (Figure  1B).
Histopathological features of the pediatric glioma reported. (A) Microcalcifications. (B) A prominent micro-vascular stroma presenting branching capillaries with endothelial tumefaction can be observed. (C) Anaplastic aspect with high nuclear to cytoplasmic ratio and mitosis was present. (D) Intermingled "egg-fried" cells can be observed in a number of anaplastic foci.
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F2
Micro-calcifications were present but there was no necrosis (Figure  2A). A prominent micro-vascular stroma presenting branching capillaries with endothelial tumefaction was observed (Figure  2B). Most tumor cells had an anaplastic aspect with a high nuclear to cytoplasmic ratio, and mitosis were present (Figure  2C). However, intermingled "fried-egg" cells were observed in a number of anaplastic foci (Figure  2D).
Tumor immunoreactivity. (A) GFAP immunoreactivity was variable whereas Synaptophysin was negative. (B) Cytoplasmic immunoreactivity for Vimentin and CD57 (HNK-1) were positive. (C) Nuclear p53 was positive in 15%-20% of cells. (D) Growth fraction (ki 67) was approximately 30%.
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F3
GFAP immunoreactivity was variable whereas Synaptophysin was negative (Figure  3A). Cytoplasmic immunoreactivity for Vimentin and CD57 (HNK-1) were positive (Figure  3B), and. nuclear p53 was positive in 15%-20% of cells (Figure  3C). The growth fraction (ki 67) was approximately 30% (Figure  3D).