PMC6662482_01
PET-CT scan images. (a) Pathologically enlarged, metabolically active left axillary lymph node. (b) Metabolically active thickening and seroma around left breast implant.
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PET CT scan confirmed increased uptake in the left axillary node and around the left breast implant (Figure 1), without other evident areas of disease.
(a) Surgically removed textured silicone implant. (b) Fibrous capsule from which the implant was removed; solid BIA-ALCL deposits on the internal surface; (c) seroma fluid from inside the fibrous capsule which contained CD30-positive atypical lymphocytes.
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Surgery was performed with en bloc capsulectomy and removal of the implant (Figure 2).
(a) H&E axillary lymph node showing ALCL; (b) H&E capsule showing BIA-ALCL; (c) CD30 positive immunohistochemical staining on capsular lymphoma cells.
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Histopathological examination (Figure 3) demonstrated both the breast capsule and lymph node to be infiltrated with CD30 positive, ALK-negative BIA-ALCL.
A: family pedigree. Proband for this case report is family member A. Other cancer-affected relatives: B-D, as described in the article.
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The pedigree is shown in Figure 4.