PMC5143733_01
Clinical picture of the bullous lesion along with histopathologic examination of the biopsy specimen. (a) Picture showing bullous lesion on the surface of skin. (b) Histopathologic examination of the specimen shows a punch biopsy specimen Haematoxylin and Eosin (H&E) stain at 40x. Subepidermal vesicle formation is seen with inflammatory infiltrate in the vesicular space. (c) H&E stained specimen at 100x Basket weave stratum cornea is seen overlying epidermis with some exocytosis of neutrophils. (d) H&E staining at 400x. Within the papillary dermis a perivascular infiltrate of neutrophils and lymphocytes with occasional eosinophils is seen.
CRIN2016-6713807.001.jpg
PMC5143733_01_CRIN2016-6713807.001.jpg
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Peripheral arterial pulses were all absent, and no bruits could be heard over carotids, abdomen, or femoral; however, skin examination revealed extensive bullous lesions over the extremities extensor surfaces and trunk (Figure 1(a)). Deposition of fibrinogen was seen in a vascular pattern in papillary dermis that was suggestive of dermatitis herpetiformis versus linear IgA bullous dermatosis (LABD), with no evidence of calciphylaxis (Figure 1).