PMC6360957_01
Two infiltrated plaques with exulcerated center, located on the right
epicanthus and in the left malar region
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f1
Two ulcerated, crusted, erythematous infiltrated plaques were observed: one on the right epicanthus, measuring 3 x 2cm; the other in the left malar region, measuring 4 x 2.5cm (Figure 1).
Ulcerated epidermis and remaining epithelium presenting pathological changes
of viral cytopathic effect, represented by focal necrosis, keratinocytes
with karyomegaly, multinucleation, ground- glass chromatin and molded
nuclei. Dermis showed a dense/diffuse nodular lymphocytic infiltrate, with
lymphocytes presenting pleomorphism, hyperchromatism, and grooved nuclei
(Hematoxylin & eosin, x100)
abd-94-01-0111-g02.jpg
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f2
The dermis showed a dense/diffuse nodular lymphocytic infiltrate, with lymphocytes presenting focal cytologic atypia, expressed by pleomorphism, hyperchromatism and grooved nuclei (Figure 2).
Post-treatment, healed lesions
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f3
After oral administration of acyclovir (400mg, five times daily) for one week, the lesions were completely healed (Figure 3).