PMC4421565_01
Light microscopy revealed mild mesangial prominence and focal increase in endolumenal cells. No global or segmental glomerulosclerosis was noted. A proximal tubule (center, bottom) shows mild acute injury (PAS reaction, original magnification x40).
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fig1
Glomeruli showed up to mild mesangial proliferation, with occasional foci of increased cells within capillary lumens (Figure 1).
Ultrastructural studies revealed widespread acute podocyte injury, with near total foot process effacement as well as microvillous transformation and condensation of the actin cytoskeleton. Some proteinaceous material is noted in the capillary lumen (electron microscopy, original magnification x8000).
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fig2
Electron microscopy of two glomeruli confirmed the above findings and revealed near total podocyte foot process effacement with associated microvillous transformation (Figure 2).