PMC4159182_01
Schematic illustration of different types of database sources that need to be created for the analysis of cases (patients) versus healthy individuals (controls).. Since these data are as a rule stored in different domains (clinical and research), a single case-control study needs to collect the data several times during a study, and this cycle must be repeated whenever a new case-control study is initiated.
pone.0104382.g001.jpg
PMC4159182_01_pone.0104382.g001.jpg
pone-0104382-g001
To this end, our requirements at Karolinska University Hospital, Karolinska Institutet and Stockholm County Council have guided and motivated us to initiate a research and development project aimed at building an informatics system for integrating healthcare and clinical research databases, hence bridging the clinical and research domains as illustrated in figure 1.
PMC4159182_02