PMC4246609_01
T1-weighted gadolinium enhanced magnetic resonance imaging revealing a tumor signal in the deep lobe of the parotid gland.
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Magnetic resonance imaging (Fig. 1) identified a neoplasm of ~2 cm in diameter located in the deep lobe of the parotid gland and involving the exofacial parotid gland.
(A) Tumor in the primary site arranged in a glandular pattern with necrosis in the center of the duct (H&E; magnification, x100). (B) Tumor in the lymph node demonstrating a similar structure as observed in (A) (H&E; magnification, x100). (C) Positive HER-2 expression in the tumor sample (ABC; magnification, x100). (D) Diffusely positive CK-H expression and (E) moderately positive CK8/CK18 expression (ABC; magnification, x100). (F and G) The expression of p63 and calponin located in the myoepithelial surrounding the salivary ducts (ABC; magnification X100). H&E, hematoxylin and eosin; ABC, avidin-biotin complex; CK, cytokeratin; CK-H, high molecular weight CK.
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Frozen sections of the lymph nodes confirmed that six out of eight nodes contained malignant cells, highly suggestive of salivary gland carcinoma (Fig. 2B).