PMC3506153_01
Change in phantom limb pain during therapy. (A) Case 1 shows initial use of paroxetine which was partially effective but required high doses. Stepwise switch to milnacipran continued to improve pain relief, leading to a long-term near-total absence of pain. (B) Case 2 shows a dramatic reduction in pain within 6 days of introduction of milnacipran. Total pain relief was obtained after less than 4 weeks of therapy. (C) Case 3 shows that administration of quetiapine to control delirium had no effect on pain relief produced by milnacipran, which was complete within a month. Subsequent resurgences of pain were controlled by increasing the dose of milnacipran.. Abbreviation: VAS, visual analog scale for pain scored in cm on a 10 cm scale.
ndt-8-549f1.jpg
PMC3506153_03_ndt-8-549f1.jpg
f1-ndt-8-549
Figure 1C). Following reports of pain in the left upper arm, a diagnosis of pathological bone fracture resulting from metastasis of liver cancer was made.
PMC3506153_02
Change in phantom limb pain during therapy. (A) Case 1 shows initial use of paroxetine which was partially effective but required high doses. Stepwise switch to milnacipran continued to improve pain relief, leading to a long-term near-total absence of pain. (B) Case 2 shows a dramatic reduction in pain within 6 days of introduction of milnacipran. Total pain relief was obtained after less than 4 weeks of therapy. (C) Case 3 shows that administration of quetiapine to control delirium had no effect on pain relief produced by milnacipran, which was complete within a month. Subsequent resurgences of pain were controlled by increasing the dose of milnacipran.. Abbreviation: VAS, visual analog scale for pain scored in cm on a 10 cm scale.
ndt-8-549f1.jpg
PMC3506153_03_ndt-8-549f1.jpg
f1-ndt-8-549
Figure 1C). Following reports of pain in the left upper arm, a diagnosis of pathological bone fracture resulting from metastasis of liver cancer was made.
PMC3506153_03
Change in phantom limb pain during therapy. (A) Case 1 shows initial use of paroxetine which was partially effective but required high doses. Stepwise switch to milnacipran continued to improve pain relief, leading to a long-term near-total absence of pain. (B) Case 2 shows a dramatic reduction in pain within 6 days of introduction of milnacipran. Total pain relief was obtained after less than 4 weeks of therapy. (C) Case 3 shows that administration of quetiapine to control delirium had no effect on pain relief produced by milnacipran, which was complete within a month. Subsequent resurgences of pain were controlled by increasing the dose of milnacipran.. Abbreviation: VAS, visual analog scale for pain scored in cm on a 10 cm scale.
ndt-8-549f1.jpg
PMC3506153_03_ndt-8-549f1.jpg
f1-ndt-8-549
Figure 1C). Following reports of pain in the left upper arm, a diagnosis of pathological bone fracture resulting from metastasis of liver cancer was made.