PMC4085295_01
Clinical course of lamivudine or entecavir and tenofovir disoproxil fumarate therapy.. Abbreviations: ALT, alanine aminotransferase; ETV, entecavir; HBV, hepatitis B virus; LAM, lamivudine; TDF, tenofovir disoproxil fumarate.
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Moreover, ALT was elevated in September 2013 (Figure 1).
Evolution of the viral polymerase reverse transcriptase protein sequence (amino acids 1-344) during lamivudine, entecavir, and tenofovir disoproxil fumarate therapy.. Notes: The AB033550 strain was reported by Okamoto et al. In June 2010, two kinds of strain were identified, June 2010-1 and -2.. Abbreviation: rt, reverse transcriptase.
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Since April 2013 (month 31 of TDF and ETV treatment), amino acid substitutions of rtL180M, rtS202G, and rtM204V have emerged and have been found to be associated with an increase in serum HBV DNA (Figure 2).