PMC10276541_01
Ectopic thyroid tissue found in breast. Hematoxylin and eosin (HE) staining shows thyroid-like structure (*) and breast structure (triangles). The scale bar is 1 mm.
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The HE staining image (Figure 1) showed mammary gland structures including glandular acinus and cystic hyperplasia, which accompanied usual ductal hyperplasia and columnar cell lesions.
IHC staining of ectopic thyroid tissue. (a) HE staining shows TFCs and colloids. (b) Positive immunohistochemistry staining of TG. (c) Positive staining of TTF-1. (d) Positive staining of TPO. The scale bar is 100 mum.
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The thyroid tissue regions had obvious thyroid-like follicles that containing pink colloid and were surrounded by cells with similar character of thyroid follicular epithelial cells (Figure 2a). IHC staining indicated that thyroglobulin (TG) distributing in thyroid follicles, suggesting the origin of thyroid tissues (Figure 2b). Thyroid transcription factor-1 (TTF-1) expressed in cells which surrounding follicles revealed follicular cells (Figure 2c). Thyroid peroxidase (TPO) existed in the apical membrane of the thyrocyte further confirmed ectopic thyroid gland (Figure 2d).