PMC4199190_01
MR images obtained from a 60-year-old woman with diplopia. Axial T1-weighted images without (A) and with (B) contrast enhancement demonstrate a solitary, contrast-enhancing mass lesion within the fourth ventricle. The mass has an isointense signal to cortex on both fluid-attenuated inversion recovery (FLAIR) (C) and T2-weighted (D) pulse sequences.
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Figure1
A magnetic resonance (MR) image of the brain demonstrated an ovoid fourth ventricular mass that was homogeneously enhancing with contrast material and extended from the left lateral recess of the fourth ventricle to the adjacent paramedian cerebellum without obstructive hydrocephalus (Figure 1).
A: Hematoxylin-eosin staining of the PCNSL shows discohesive, large, pleomorphic cells with mitosis and apoptosis. Immunohistochemistry shows diffuse strong reactivity for CD20 (B) and CD10 (C). D: the Ki67 labeling index of the PCNSL is close to 100%.
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Figure2
Pathologic examination of the tumor revealed discohesive, large, pleomorphic cells that were strongly immunoreactive for CD45, CD20 and CD10 proteins, with a Ki-67 proliferation index of nearly 100% (Figure 2).
PMC4199190_02