PMC5634960_01
Hematoxylin and Eosin stain of aspirate material from FNA of left thyroid lobe nodule. a Cellular aspirate smear consisting of epithelial elements admixed with red blood cells (200X). b Follicular cells with elongate/spindle nuclei, dispersed chromatin, and abundant eosinophilic granular cytoplasm (400X)
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Fig1
A repeat FNA of the right-sided nodule was subsequently determined to be suspicious for malignancy carrying a 60-75% malignancy rate (Fig. 1).
HTT (superior) juxtaposed with uninvolved thyroid parenchyma (inferior) with intervening fibrous capsule (H&E, 200X)
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Fig2
Extracellular hyalinization and prominent stromal dystrophic calcification could also be appreciated (Figs. 2 and 3).
Representative sections of HTT. a Organoid and trabecular growth pattern with prominent stromal dystrophic calcifications (H&E, 100X). b Higher magnification of features shown in A (H&E, 200X). c Neoplastic cells with predominantly spindle morphologic, clumped nuclear chromatin, and abundant granular eosinophilic cytoplasm (H&E, 400X)
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Fig3
Extracellular hyalinization and prominent stromal dystrophic calcification could also be appreciated (Figs. 2 and 3).