PMC9744190_01
PMC9744190_02
(A) Long-term evolution of allograft function of patients included in the CNI weaning protocol. All patients with a decrease > 50% of eGFR at long-term were those with IgA glomerulonephritis recurrence. (B) Long-term evolution of proteinuria of patients included in the CNI weaning protocol. (C) Representation of DSA's maximal MFI. 3/5 patients who underwent tacrolimus withdrawal presented an early occurrence of de novo DSA with a MFI > 2000, quickly reversed after specific treatment. 2 patients developed a de novo DSA long term after the study, independently of their inclusion group.
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TAC group and 1 in the TAC group,  Figures 1A, B ). Two patients were reported to have late adherence issues and thus developed another long-term dnDSA (6 and 9 years) after the study. Interestingly, all dnDSA that occurred during the study period following tacrolimus weaning remained non-detectable (MFI < 1000) at long-term follow-up ( Figure 1C ).
PMC9744190_03