PMC10374946_01
Diagnosis of nasopharynx cancer. (A,B) Diagnostic imaging result. A mass on the posterior wall of the nasopharynx: the red arrow points to. (C) Image of pathological diagnosis. Magnification; x40 andx100. A paraffin section of the mass was stained with HE, showing obvious tumor nests, oval nuclei: the yellow arrow points to. (D) P63 immunohistochemical staining. Magnification;x40 and x100. A paraffin section of the mass was stained with P63, a large number of P63-positive cells can be seen under the basement membrane, squamous cell carcinoma is positive for P63: the red arrow points to. P63-positive cells indicated by blue arrows are the basement membrane.
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F1
The first doctor performed a contrast-enhanced magnetic resonance scan of the nasopharynx, which showed a mass on the posterior wall of the nasopharynx, then we reexamined a 3-T contrast-enhanced MRI (Figures 1A, B ). The patient was subsequently diagnosed with NPC by pathological biopsy (Figures 1C, D ).
Timeline of treatment and radiographic responses. (A) Timeline of treatment. (B) Imaging results showing regression of the lesion and demonstrating the effectiveness of the anlotinib combined with ticeorgio regimen.
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F2
All treatments resulted in PR (Figure 2A). During the timely periodic follow-up checks, residual tumor foci decreased further in size, and the final assessment of efficacy was cCR (Figure 2B 2019.07.03). However, the result of the sixth month's follow-up examination revealed parapharyngeal lymph node exhibited a trend toward increasing size (Figure 2B 2020.02.10). And a subsequent MR (Figure 2B 2020.07.17) scan showed further enlargement of the parapharyngeal lymph nodes, leading to invasion of the parapharyngeal space and the lateral pterygoid muscle.