PMC4640583_01
Clinicopathologic description of invasive mucormycosis and RM1 strain characterization.. (A) Computerized tomography showing multi-focal sinusitis (red arrows). (B) 20x magnification of hematoxylin and eosin stain of nasal tissue showing chaining chlamydospores in an area of necrotic tissue mimicking toruloid septate hyphae (red arrow shows immature chlamydospores). Scale bar = 50 muM. (C) 20x magnification of Papanicolaou stain of biopsy of lower extremity nodule showing chronic inflammation and invasive, non-septated hyphal form. (D) 100x magnification of microscopic morphology of strain RM1grown on Sabourad-Dextrose-Emmons agar at 30 C for 48 hrs showing barrel-shaped chlamydospores that resemble pauci-septate hyphae. Scale bar = 10 muM.
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Unexplained fevers began on day 24, and a CT scan showed invasive sinusitis (Fig 2A). Nasal biopsy revealed tissue invasion by septated hyphae consistent with hyalohyphomycetes (Fig 2B). Biopsy showed invasive hyphal elements consistent with disseminated mucormycosis (Fig 2C).