PMC4813628_01
Celiac disease - endoscopic appearance
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F1
Upper digestive endoscopy showed the loss of Kerckring folds in the descending duodenum, which is a characteristic feature for celiac disease (Fig. 1).
Marked villous atrophy and increased number of intraepithelial lymphocytosis, HE, 200x
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F2
Histologic examination completed with immunohistochemical tests confirmed the diagnosis of gluten-sensitive enteropathy grade 3 C ( Oberhuber): complete villous atrophy, decreased number of caliciform cells and lymphoplasmocitary infiltration of lamina propria with raised intraepithelial lymphocyte count (Fig. 2).
Immunohistochemistry: CD 3 positive intraepithelial T lymphocytes, 400x
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F3
Immunohistochemistry examination recognized typical findings: CD3 positive within intraepithelial lymphocytes, CD4 positive in the small lymphocytes of lamina propria and CD8 positive in the small intraepithelial lymphocytes (Fig. 3,4).