PMC9989185_01
(A, B) Case 1-Sagittal MRI demonstrating eccentric patchy abnormal intramedullary high STIR signal and enhancement within the spinal cord, most conspicuous at the level of C6/C7 and T5 (arrows); (C) Case 2-Sagittal and (D, E) axial MRI images showing longitudinally extensive abnormal T2 signal hyperintensity in the cord from T4/T5 to T12 with a faint focus of cord signal hyperintensity at C5/C6 and at T1/2; (F) Case 3-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity in the mid-thoracic cord on initial presentation and (G) extending to involve the mid- to lower cervical spinal cord 2 weeks later; (H) Case 4-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity from mid-thoracic cord T6/T7, extending to the conus medullaris (I).
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F1
An MRI whole spine demonstrated extensive central high T2 signal within the spinal cord from T6/T7 level to the conus medullaris, with evidence of contrast enhancement at T10/T11 (Figures 1H, I).
Timeline of each patient presented (IVMP, intravenous methylprednisolone; OD, once daily; TM, transverse myelitis; IVIg, intravenous immunoglobulin; BD, twice daily; PLEX, plasmapheresis; ICI, immune checkpoint inhibitor; TDS, three times daily).
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PMC9989185_01_fneur-14-1130313-g0002.jpg
F2
PMC9989185_02
(A, B) Case 1-Sagittal MRI demonstrating eccentric patchy abnormal intramedullary high STIR signal and enhancement within the spinal cord, most conspicuous at the level of C6/C7 and T5 (arrows); (C) Case 2-Sagittal and (D, E) axial MRI images showing longitudinally extensive abnormal T2 signal hyperintensity in the cord from T4/T5 to T12 with a faint focus of cord signal hyperintensity at C5/C6 and at T1/2; (F) Case 3-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity in the mid-thoracic cord on initial presentation and (G) extending to involve the mid- to lower cervical spinal cord 2 weeks later; (H) Case 4-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity from mid-thoracic cord T6/T7, extending to the conus medullaris (I).
fneur-14-1130313-g0001.jpg
PMC9989185_04_fneur-14-1130313-g0001.jpg
F1
An MRI whole spine demonstrated extensive central high T2 signal within the spinal cord from T6/T7 level to the conus medullaris, with evidence of contrast enhancement at T10/T11 (Figures 1H, I).
PMC9989185_03
(A, B) Case 1-Sagittal MRI demonstrating eccentric patchy abnormal intramedullary high STIR signal and enhancement within the spinal cord, most conspicuous at the level of C6/C7 and T5 (arrows); (C) Case 2-Sagittal and (D, E) axial MRI images showing longitudinally extensive abnormal T2 signal hyperintensity in the cord from T4/T5 to T12 with a faint focus of cord signal hyperintensity at C5/C6 and at T1/2; (F) Case 3-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity in the mid-thoracic cord on initial presentation and (G) extending to involve the mid- to lower cervical spinal cord 2 weeks later; (H) Case 4-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity from mid-thoracic cord T6/T7, extending to the conus medullaris (I).
fneur-14-1130313-g0001.jpg
PMC9989185_04_fneur-14-1130313-g0001.jpg
F1
An MRI whole spine demonstrated extensive central high T2 signal within the spinal cord from T6/T7 level to the conus medullaris, with evidence of contrast enhancement at T10/T11 (Figures 1H, I).
PMC9989185_04
(A, B) Case 1-Sagittal MRI demonstrating eccentric patchy abnormal intramedullary high STIR signal and enhancement within the spinal cord, most conspicuous at the level of C6/C7 and T5 (arrows); (C) Case 2-Sagittal and (D, E) axial MRI images showing longitudinally extensive abnormal T2 signal hyperintensity in the cord from T4/T5 to T12 with a faint focus of cord signal hyperintensity at C5/C6 and at T1/2; (F) Case 3-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity in the mid-thoracic cord on initial presentation and (G) extending to involve the mid- to lower cervical spinal cord 2 weeks later; (H) Case 4-Sagittal MRI images demonstrating longitudinally extensive abnormal T2 signal hyperintensity from mid-thoracic cord T6/T7, extending to the conus medullaris (I).
fneur-14-1130313-g0001.jpg
PMC9989185_04_fneur-14-1130313-g0001.jpg
F1
An MRI whole spine demonstrated extensive central high T2 signal within the spinal cord from T6/T7 level to the conus medullaris, with evidence of contrast enhancement at T10/T11 (Figures 1H, I).