PMC4065452_01
Tumor extending from distal aspect of 37 to uvula
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F1
Intraorally there was a pedunculated and ulcerated growth covered with slough, extending from the distal aspect of 37 to uvula, measuring approximately 5 x 3 cm [Figure 1].
Photomicrograph showing epithelial component around the glandular spaces and arranged in solid nests surrounded by spindle component. (H&E stain, x400)
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F2
These were surrounded by sheets of spindle cells with marked atypical nuclei [Figure 2].
Immunohistochemistry revealed strong nuclear positivity of tumor cells for Transducer-like enhancer of split 1 (TLE1) in both spindle and epithelial component (IHC stain, x100)
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F3
Immunohistochemistry revealed strong nuclear positivity in both the components for transducer-like enhancer of split 1 (TLE1) [Figure 3], epithelial membrane antigen (EMA) positivity [Figure 4] in the cuboidal epitheloid cells, vimentin [Figure 5] and Bcl-2 positivity [Figure 6] in the spindle cells, which confirmed the diagnosis of biphasic SS (BSS).
Immunohistochemistry revealing Epithelial Membrane Antigen (EMA) positivity in the cuboidal epitheloid cells and negativity in the spindle cells (IHC stain, x100)
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F4
Immunohistochemistry revealed strong nuclear positivity in both the components for transducer-like enhancer of split 1 (TLE1) [Figure 3], epithelial membrane antigen (EMA) positivity [Figure 4] in the cuboidal epitheloid cells, vimentin [Figure 5] and Bcl-2 positivity [Figure 6] in the spindle cells, which confirmed the diagnosis of biphasic SS (BSS).
Immunohistochemistry revealing vimentin positivity in the spindle cells and negativity in the cuboidal cells (IHC stain, x400)
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F5
Immunohistochemistry revealed strong nuclear positivity in both the components for transducer-like enhancer of split 1 (TLE1) [Figure 3], epithelial membrane antigen (EMA) positivity [Figure 4] in the cuboidal epitheloid cells, vimentin [Figure 5] and Bcl-2 positivity [Figure 6] in the spindle cells, which confirmed the diagnosis of biphasic SS (BSS).
Immunohistochemistry revealing Bcl-2 positivity in the spindle cells (IHC stain, x100)
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F6
Immunohistochemistry revealed strong nuclear positivity in both the components for transducer-like enhancer of split 1 (TLE1) [Figure 3], epithelial membrane antigen (EMA) positivity [Figure 4] in the cuboidal epitheloid cells, vimentin [Figure 5] and Bcl-2 positivity [Figure 6] in the spindle cells, which confirmed the diagnosis of biphasic SS (BSS).