PMC4629615_01
Heart: Left ventricular hypertrophy and right ventricular dilatation.
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F1
Mitral valve leaflets are fleshy, shrunk and nodular.
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F2
The mitral valve leaflets were unevenly thickened, fleshy and shrunk (Fig. 2).
The lung is severely congested, edematous and dark red in color.
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F3
The lungs were severely congested and oozed blood from cut surfaces (Fig. 3).
The liver showing typical nutmeg appearance of venous congestion.
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F4
The liver was enlarged and showed typical nutmeg appearance (Fig. 4).
A segment of the small intestine showing severe sub-serosal petichial and ecchymotic hemorrhages.
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F5
The small intestine contained little food and showed sub-serosal petechial and ecchymotic hemorrhages on a segment measuring about 25 cm (Fig. 5).
Mitral valve showing fibromyxomatous degeneration formed of loosely arranged stellate fibroblast.(H&E x10).
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F6
Mitral valve showing fibromyxomatous degeneration and mucopolysaccharide-rich ground substance (Alcian blue, x10).
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F7
The lung showing edema and severe vascular congestion (H&E, x40).
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F8
The pulmonary vessels and capillaries were severely congested with accumulation of transudate in air capillaries (Fig. 8).
The liver shows congestion in a centrilobular vein and close sinusoids, necrosis in the centrilobular hepatocytes (right) and fatty degeneration in the outer hepatic zones (H&E, x20).
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F9
The hepatocytes close to the inner zone were necrosed, while those in the middle and portal zones were loaded with fat vacuoles (Fig. 9).
Renal glomeruli are moderately enlarged and show segmental glomerulosclerosis with partial adhesion and narrowing of urinary space. The nearby arterioles are arteriosclerotic.
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F10
The renal arterioles in many instances had onion like thickening of their walls and narrow lumen (Fig. 10).
Smooth translucent fibrinous thrombi in renal intertubular capillaries (H&E, x40).
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F11
Septic mural thrombi were observed in many medium-sized vessels, while homogenous micro-thrombi were noticed in many capillaries (Fig. 11).
Small intestine showing villous cicatrisation and atrophy. The submucosal arterioles are distorted, partially obliterated and hyalinized (H&E, x10).
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F12
The overlying mucosal villi were sclerotic and atrophied (Fig. 12).
A myocardial arteriole showing wall thickening with hyalinization (H&E, x40).
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F13