PMC3917591_01
Clinical appearance of patient 1. (A) Up to 12 mm oval erythematous plaques on the patient's face are shown. (B) Histopathological findings of patient 1 (hematoxylin and eosin stain, original magnification, x100). Naked epithelioid cell granulomas accompanied by giant cells were observed in the upper dermis. (C) Positron emission tomography image of patient 1. Mediastinal and hilar lymph nodes show positive results. (D) Cardiac apex shows accumulation of 18F-fluorodeoxyglucose. (E) A positive result in the diaphragm is shown. (F) The left parotid gland was also positive.
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PMC3917591_01_1752-1947-8-17-1.jpg
F1
Physical examination revealed up to 12mm oval erythematous plaques on his face (Figure 1A). Histopathologically, naked epithelioid cell granulomas with giant cells were observed in the upper dermis (Figure 1B). PET-CT images revealed mediastinal and hilar LN swelling (Figure 1C), as well as involvement of the myocardium (Figure 1D), diaphragm (Figure 1E) and left parotid gland (Figure 1F).
PMC3917591_02
Clinical appearance of patient 2. (A) Five-millimeter, irregularly shaped plaques are shown. (B) Histopathological findings of patient 2 (hematoxylin and eosin stain; original magnification x 100). Naked epithelioid cell granuloma with giant cells can be seen in the upper dermis. (C) Positron emission tomography image of patient 2. Multiple myocardial focal uptakes are observed at the middle to inferior wall. HLA means horizontal long axis, VLA means vertical long axis, and SA means short axis in Figure 2-C.
1752-1947-8-17-2.jpg
PMC3917591_02_1752-1947-8-17-2.jpg
F2
Her physical examination revealed 5mm, irregularly shaped plaques on her face (Figure 2A). Histopathologically, naked epithelial cell granuloma with giant cells were observed in the upper dermis (Figure 2B). PET-CT images revealed mediastinal and hilar lymph node (LN) swelling and multiple middle and inferior myocardial wall uptakes (Figure 2C).