PMC8188964_01
(1) Metastatic carcinoma cells from the breast cells infiltrating urinary bladder (hematoxylin-eosin 400x). (2) Gross cystic disease fluid protien-15 immunostaining is positive in the tumor cells, confirming breast cancer. (3) Estrogen receptor shows >90% positivity with strong nuclear staining. (4) Progesterone receptor immunostaining is positive with weak to moderate intensity in about 15% of tumor cell nuclei.
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Histopathology came back significant for metastatic breast cancer, consistent with her hormone receptor-positive (HR+) primary breast cancer (Figure 1).