PMC8633843_01
As shown in MIP of 18F-FDG PET, 18F-FDG uptake in the petrous part of right temporal bone [(A), arrows], right foramen magnum, right four anterior ribs, left five lateral ribs and posterior ribs, left eight posterior ribs [(A), arrows], left pedicle of Lumbar 3 vertebral body [(A), arrows], and bilateral ilium [(A), arrowhead] are revealed and characterized with osteolytic bone destruction. Axial CT, PET, and fusion PET/CT images of representative involve bone lesions, including the petrous part of right temporal bone [(B-D), arrows; SUVmax, 20.3] and bilateral ilium [(E-G), arrowhead; SUVmax, 20.3], which are exhibited. In addition, the image shows the 18F-FDG uptake in the abdominal lymph nodes peri-pancreatic, indicating pheochromocytoma metastasis [(H-J), arrow; SUVmax, 5.2].
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F1
An 18F-FDG PET/CT scan reported abdominal lymph node metastasis (SUVmax, 5.2) and multiple bone metastasis (SUVmax, 20.3) (Figure 1), accompanied by FDG uptake of bilateral vertebrae and intercostal muscles (SUVmax, 6.5) related to brown fat uptake (Figure 2).
In this case, 18F-FDG uptake (SUVmax, 6.5) is seen in the bilateral vertebrae and intercostal muscles. Representative brown adipose tissue in the thoracic vertebra transverse process [(B-D), arrows] and in posterior intercostal space [(E-G), arrowhead] in the axial CT, PET, and fusion PET/CT images is exhibited. The most common location for brown adipose tissue that is detectable in adults by PET/CT is the blue area in (A).
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F2
An 18F-FDG PET/CT scan reported abdominal lymph node metastasis (SUVmax, 5.2) and multiple bone metastasis (SUVmax, 20.3) (Figure 1), accompanied by FDG uptake of bilateral vertebrae and intercostal muscles (SUVmax, 6.5) related to brown fat uptake (Figure 2).
Biopsies of the left ilium demonstrated the presence of metastasis of malignant pheochromocytoma. That tumor cells are spindle shaped and oval, with abundant cytoplasm and pink staining, and the nuclei are round, oval, and deeply stained, which are observed in the microscopic section of hematoxylin-eosin stain [(A,B), original magnification x 10].
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F3
The bone biopsy of left iliac (Figure 3) considered metastasis of malignant pheochromocytoma.