PMC5735622_01
Plasmablastic lymphoma. The tumor cell was large with prominent nucleoli (a) (H&E staining, magnification x600) and positive for Epstein-Barr virus by in situ hybridization with the EBER probe (b) (DAB, magnification x400).
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fig1
Biopsies from the polypoid mass of the ileum-cecum valve and the lytic lesion of the left humerus (Figure 1) revealed infiltration by neoplastic cells with plasmablastic traits and expression of CD38, CD138, MUM-1/IRF4, CD79a, and CD30.
Bone marrow biopsy with limited interstitial infiltration by CLL. The neoplastic cells were small and round (a) (H&E staining, magnification x200) expressing CD20 (b), CD5 (c), and CD23 (d) (DAB, magnification x200).
CRIHEM2017-2861596.002.jpg
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fig2
B cells (CD20+, CD23+, and CD5+) compatible with CLL (Figure 2). Bone marrow cytogenetics was normal (46, XY).