PMC4397003_01
Intraoral picture showing growth in the lower left posterior region on lingual and distal aspect of 36.
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fig1
The growth was sessile, dark red in colour, firm in consistency, tender on palpation, and nonfluctuant (Figure 1).
Orthopantomograph showing no bony involvement.
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fig2
The orthopantomograph showed no bony involvement (Figure 2).
Intertwining bundles of spindle cells with abundant extracellular collagenous matrix (H&E stain, original magnification x40).
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fig3
The tumor was composed mainly of streaming and interlacing fascicles of spindle-shaped cells resembling fibroblasts or smooth muscle cells, suggesting myofibroblastic differentiations (Figure 3), and a few mitotic figures.
Groups of densely packed cells adjacent to angular hemangiopericytoma-like blood vessels (H&E stain, original magnification x40).
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fig4
In some areas, the lesional cells appeared to be round or polygonal and closely packed (Figure 4).
Bundles of lesional spindle cells intensely positive for alpha-smooth muscle actin (original magnification x40).
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fig5
Immunohistochemistry showed a positive reaction in the tumor cells for alpha-smooth muscle actin (alpha-SMA) (Figure 5) but no immunoreactivity for antibodies directed against CD34 (Figure 6).
Lesional cells are negative for CD34. Positive stain highlights the extensive vascular network of the lesion (original magnification x40).
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fig6
Immunohistochemistry showed a positive reaction in the tumor cells for alpha-smooth muscle actin (alpha-SMA) (Figure 5) but no immunoreactivity for antibodies directed against CD34 (Figure 6).