PMC5437481_01
Anterior segment photography and corneal topography of 3 patients with unilateral posterior polymorphous corneal dystrophy. a Anterior segment photography of a 25-year-old male (Case 1). The left eye showed a horizontal band-like lesion at the level of Descemet's membrane and the corneal endothelium (arrowheads). b Corneal topography of case 1 revealed a bow tie, with-the-rule (WTR) astigmatism (steep K = 43.55 D x 107, flat K = 41.46 D x 17). Interestingly, the corneal astigmatism flat cylinder axis corresponded to the band lesion axis. c Corneal topography of the uninvolved eye of case 1 showed a mild WTR astigmatism (steep K = 42.83 D x 93, flat K = 42.08 D x 3). d Anterior segment photography of an 11-year-old boy (Case 2). The left eye showed a snail-track lesion at the level of Descemet's membrane along the superotemporal cornea (arrowheads). e Corneal topography of case 2 showed an asymmetric bow tie WTR astigmatism with superior steepening (steep K = 50.98 D x 95, flat K = 43.72 D x 5). f Corneal topography of the uninvolved eye of case 2 showed a mild WTR astigmatism (steep K = 46.30 D x 93, flat K = 44.76 x 3). g Anterior segment photography of a 4-year-old girl (Case 3). It showed a band-like lesion along the 40 -50  meridians at the level of Descemet's membrane (arrowheads). h Corneal topography of case 3 revealed a bow tie WTR astigmatism (steep K = 45.5 D x 95, flat K = 42.7 D x 5). i Corneal topography of the uninvolved eye of case 3 showed a mild WTR astigmatism (steep K = 44.7 D x 90, flat K = 43.1 D x 180).
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F1
Slit-lamp examination revealed a band-like lesion along the 40-50  meridians at the level of Descemet's membrane in the left eye (Fig. 1g). Corneal topography (Orbscan II) showed a bow tie WTR astigmatism (steep K = 45.50 D x 95, flat K = 42.70 D x 5; Fig. 1h) in the left eye and a more mild WTR astigmatism (steep K = 44.70 D x 90, flat K = 43.10 D x 180; Fig. 1i) in the right eye.
Specular microscopy images of patients with unilateral posterior polymorphous corneal dystrophy (PPCD). a, b A 25-year-old male with PPCD in his left eye (Case 1). In the right eye (a), no abnormalities were seen, and the endothelial cell count was 2,941 cells/mm2. In the left eye (b), variations in cell size and morphology were observed, and the endothelial cell count was 1,529 cells/mm2. c, d An 11-year-old boy with PPCD in his right eye (Case 2). In the right eye (c), variations in cell size and morphology were observed and the endothelial cell count was 1,730 cells/mm2. In the left eye (d), no abnormalities were observed, and the endothelial cell count was 2,570 cells/mm2. e, f A 4-year-old girl with PPCD in her left eye (Case 3). In the right eye (e), no abnormalities were seen, and endothelial cell count was 3,322 cells/mm2. In the left eye (f), variations in cell size and morphology were seen, and the endothelial cell count was 1,845 cells/mm2.
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F2
Noncontact specular microscopy revealed an endothelial cell density of 3,322 and 1,845 cells/mm2 in the right and left eyes, respectively (Fig. 2e, f).
Anterior segment optical coherence tomography of a patient (Case 1). It showed irregular posterior endothelial surface with hyperreflectivity in his left eye.
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F3
Anterior segment optical coherence tomography (Spectralis OCT; Heidelberg Engineering, Heidelberg, Germany) revealed an irregular, hyper-reflective posterior endothelial surface in the left eye (Fig. 3).
PMC5437481_02
Anterior segment photography and corneal topography of 3 patients with unilateral posterior polymorphous corneal dystrophy. a Anterior segment photography of a 25-year-old male (Case 1). The left eye showed a horizontal band-like lesion at the level of Descemet's membrane and the corneal endothelium (arrowheads). b Corneal topography of case 1 revealed a bow tie, with-the-rule (WTR) astigmatism (steep K = 43.55 D x 107, flat K = 41.46 D x 17). Interestingly, the corneal astigmatism flat cylinder axis corresponded to the band lesion axis. c Corneal topography of the uninvolved eye of case 1 showed a mild WTR astigmatism (steep K = 42.83 D x 93, flat K = 42.08 D x 3). d Anterior segment photography of an 11-year-old boy (Case 2). The left eye showed a snail-track lesion at the level of Descemet's membrane along the superotemporal cornea (arrowheads). e Corneal topography of case 2 showed an asymmetric bow tie WTR astigmatism with superior steepening (steep K = 50.98 D x 95, flat K = 43.72 D x 5). f Corneal topography of the uninvolved eye of case 2 showed a mild WTR astigmatism (steep K = 46.30 D x 93, flat K = 44.76 x 3). g Anterior segment photography of a 4-year-old girl (Case 3). It showed a band-like lesion along the 40 -50  meridians at the level of Descemet's membrane (arrowheads). h Corneal topography of case 3 revealed a bow tie WTR astigmatism (steep K = 45.5 D x 95, flat K = 42.7 D x 5). i Corneal topography of the uninvolved eye of case 3 showed a mild WTR astigmatism (steep K = 44.7 D x 90, flat K = 43.1 D x 180).
cop-0008-0250-g01.jpg
PMC5437481_03_cop-0008-0250-g01.jpg
F1
Slit-lamp examination revealed a band-like lesion along the 40-50  meridians at the level of Descemet's membrane in the left eye (Fig. 1g). Corneal topography (Orbscan II) showed a bow tie WTR astigmatism (steep K = 45.50 D x 95, flat K = 42.70 D x 5; Fig. 1h) in the left eye and a more mild WTR astigmatism (steep K = 44.70 D x 90, flat K = 43.10 D x 180; Fig. 1i) in the right eye.
Specular microscopy images of patients with unilateral posterior polymorphous corneal dystrophy (PPCD). a, b A 25-year-old male with PPCD in his left eye (Case 1). In the right eye (a), no abnormalities were seen, and the endothelial cell count was 2,941 cells/mm2. In the left eye (b), variations in cell size and morphology were observed, and the endothelial cell count was 1,529 cells/mm2. c, d An 11-year-old boy with PPCD in his right eye (Case 2). In the right eye (c), variations in cell size and morphology were observed and the endothelial cell count was 1,730 cells/mm2. In the left eye (d), no abnormalities were observed, and the endothelial cell count was 2,570 cells/mm2. e, f A 4-year-old girl with PPCD in her left eye (Case 3). In the right eye (e), no abnormalities were seen, and endothelial cell count was 3,322 cells/mm2. In the left eye (f), variations in cell size and morphology were seen, and the endothelial cell count was 1,845 cells/mm2.
cop-0008-0250-g02.jpg
PMC5437481_03_cop-0008-0250-g02.jpg
F2
Noncontact specular microscopy revealed an endothelial cell density of 3,322 and 1,845 cells/mm2 in the right and left eyes, respectively (Fig. 2e, f).
PMC5437481_03
Anterior segment photography and corneal topography of 3 patients with unilateral posterior polymorphous corneal dystrophy. a Anterior segment photography of a 25-year-old male (Case 1). The left eye showed a horizontal band-like lesion at the level of Descemet's membrane and the corneal endothelium (arrowheads). b Corneal topography of case 1 revealed a bow tie, with-the-rule (WTR) astigmatism (steep K = 43.55 D x 107, flat K = 41.46 D x 17). Interestingly, the corneal astigmatism flat cylinder axis corresponded to the band lesion axis. c Corneal topography of the uninvolved eye of case 1 showed a mild WTR astigmatism (steep K = 42.83 D x 93, flat K = 42.08 D x 3). d Anterior segment photography of an 11-year-old boy (Case 2). The left eye showed a snail-track lesion at the level of Descemet's membrane along the superotemporal cornea (arrowheads). e Corneal topography of case 2 showed an asymmetric bow tie WTR astigmatism with superior steepening (steep K = 50.98 D x 95, flat K = 43.72 D x 5). f Corneal topography of the uninvolved eye of case 2 showed a mild WTR astigmatism (steep K = 46.30 D x 93, flat K = 44.76 x 3). g Anterior segment photography of a 4-year-old girl (Case 3). It showed a band-like lesion along the 40 -50  meridians at the level of Descemet's membrane (arrowheads). h Corneal topography of case 3 revealed a bow tie WTR astigmatism (steep K = 45.5 D x 95, flat K = 42.7 D x 5). i Corneal topography of the uninvolved eye of case 3 showed a mild WTR astigmatism (steep K = 44.7 D x 90, flat K = 43.1 D x 180).
cop-0008-0250-g01.jpg
PMC5437481_03_cop-0008-0250-g01.jpg
F1
Slit-lamp examination revealed a band-like lesion along the 40-50  meridians at the level of Descemet's membrane in the left eye (Fig. 1g). Corneal topography (Orbscan II) showed a bow tie WTR astigmatism (steep K = 45.50 D x 95, flat K = 42.70 D x 5; Fig. 1h) in the left eye and a more mild WTR astigmatism (steep K = 44.70 D x 90, flat K = 43.10 D x 180; Fig. 1i) in the right eye.
Specular microscopy images of patients with unilateral posterior polymorphous corneal dystrophy (PPCD). a, b A 25-year-old male with PPCD in his left eye (Case 1). In the right eye (a), no abnormalities were seen, and the endothelial cell count was 2,941 cells/mm2. In the left eye (b), variations in cell size and morphology were observed, and the endothelial cell count was 1,529 cells/mm2. c, d An 11-year-old boy with PPCD in his right eye (Case 2). In the right eye (c), variations in cell size and morphology were observed and the endothelial cell count was 1,730 cells/mm2. In the left eye (d), no abnormalities were observed, and the endothelial cell count was 2,570 cells/mm2. e, f A 4-year-old girl with PPCD in her left eye (Case 3). In the right eye (e), no abnormalities were seen, and endothelial cell count was 3,322 cells/mm2. In the left eye (f), variations in cell size and morphology were seen, and the endothelial cell count was 1,845 cells/mm2.
cop-0008-0250-g02.jpg
PMC5437481_03_cop-0008-0250-g02.jpg
F2
Noncontact specular microscopy revealed an endothelial cell density of 3,322 and 1,845 cells/mm2 in the right and left eyes, respectively (Fig. 2e, f).