PMC7484737_01
Hemoglobin level as a function of time and treatments. Doses of oral steroids are specified below the respective arrows. Intravenous cyclosporin was introduced at 3 mg/kg for 3 days before being switched for oral cyclosporin 80 mg twice a day with a slow taper.
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F1
Despite a total of 29 PRBCs with a nadir at 4.3 g/dL and a thorough workup to find a source of bleeding, hemoglobin level remained persistently low (Figure 1). Nivolumab was withdrawn on day 98 after the 8th cycle, and oral corticosteroid treatment was initiated on day 135 (60 mg a day) without efficacy (Figure 1).