PMC10403978_01
Clinical images showing the occipital view of hair regrowth and colour before and after dupilumab treatment. (a) Before dupilumab treatment. (b) After one injection at week 4 of dupilumab treatment. (c) After three injections at week 12 of dupilumab treatment. (d) After seven injections at week 28 of dupilumab treatment.
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At the same time, the repigmented segment of the hair shaft continued growing longer (Figure 1).
Gross and dermoscopic view of hair repigmentation after six injections at week 24 of dupilumab treatment. (a) Photograph of the shed hair with repigmentation at the distal end. (b) Dermoscopic view of hair repigmentation (red arrow) on the scalp.
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Seven locations on the scalp were chosen, that is, in the frontal, parietal, parietal-occipital, temporal (left and right) and occipital (upper and lower) areas (Figure 2).
Percentage of black and white hairs across the scalp during dupilumab treatment. During dupilumab therapy, the proportion of white hair continuously decreased and that of repigmented black hair increased, showing a significant negative correlation between them (r = -1, p = 0.0004).
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During treatment, the proportion of white hair continuously decreased and that of repigmented black hair increased (Figure 3), showing a significant negative correlation between them (r = -1, p = 0.0004).
Increasing length of the pigmented hair shaft segment at different locations on the scalp after dupilumab administration. The average repigmentation rates on the whole scalp were 0.32 mm/day, 0.41 mm/day and 0.4 mm/day, respectively, from days 164 (week 24) to 204 (week 30), from days 204 (week 30) to 241 (week 35) and from days 241 (week 35) to 281 (week 41) after the first injection of dupilumab, which were all similar to the normal hair growth rate of 0.411 mm +- 0.053 mm/day.
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The length of the repigmented hair shaft was measured and recorded from six locations except in the lower occipitalia area on days 164 (week 24), 204 (week 30), 241 (week 35), and 281 (week 41) after the first injection of dupilumab (Figure 4).