PMC4357675_01
Exophytic nodular lesion approximately 3 x 6 cm in size with surface ulceration in the left lateral perianal region.
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F1
Dermatology examination revealed an exophytic condyloma-like nodular lesion approximately 3 x 6 cm in size with surface ulceration in the left lateral perianal region and no other pathological findings on whole body examination (fig. 1).
a Edematous stroma, mononuclear inflammatory cells, stratified squamous epithelium with epithelial cell islands containing pleomorphic cells and showing infiltrative growth and tumor cell islands with peripheral palisading. HE, x40. b The tumor islands with peripheral palisading. The tumor cells had a pleomorphic character with a large vesicular nucleus and narrow cytoplasm. HE, x400.
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F2
HIV, HSV and syphilis serology results were negative. Histopathological evaluation of a punch biopsy obtained from the lesion showed an edematous stroma containing mononuclear inflammatory cells under a stratified squamous epithelium with epithelial cell islands containing pleomorphic cells and showing infiltrative growth and tumor cell islands with peripheral palisading (fig. 2a). The tumor cells had a pleomorphic character, with a large vesicular nucleus and narrow cytoplasm (fig. 2b).