PMC3861607_01
Pathological features indicative of adenocarcinoma (H&E; magnification, x100).
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Cystoscopy identified a 4-cm whitish mass at the dome of the urinary bladder, with pathological features indicative of adenocarcinoma (Fig. 1).
Computed tomography (CT) scan of the abdomen. Arrows indicate urinary bladder masses.
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A computed tomography (CT) scan of the abdomen was performed on February 3, 2012, which demonstrated masses within the urinary bladder (Fig. 2).
(A) Glandular area (H&E; magnification, x100). (B) Cytoplasmic hyaline globules in tumour cells (H&E; magnification, x400). (C) Hepatoid and solid area (H&E; magnification, x100).
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Two similar 5-cm tumours were present, with various histological morphologies in different areas, featuring reticular, glandular, papillary, microcystic, solid and hepatoid patterns (Fig. 3).
(A) Patchy and moderate reactivity to alphaFP (magnification, x40). (B) Diffuse and strong reactivity to SALL4 (magnification, x40). alphaFP; alpha-fetoprotein; SALL4, Sal-like protein 4.
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The tumour cells showed immunohistochemical reactivity for antibodies against MNF116, alpha-fetoprotein (alphaFP) and Sal-like protein 4 (Fig. 4), but not against EMA, HCG, placental alkaline phosphatase, CD30 and octamer-binding transcription factor 3/4. The final pathological diagnosis was of a yolk sac tumour.
Computed tomography (CT) scan of the abdomen and pelvis. Arrow indicates enlarged paraaortic lymph nodes.
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A CT scan of the abdomen and pelvis on March 9, 2012, demonstrated several enlarged paraaortic lymph nodes of <=1.5 cm in size (Fig. 5).