PMC10485270_01
(A) Pedigree of the extended family with no ALS history; (B) Sanger sequencing results of family members. The index patient is heterozygous for c.140A>G mutation, while neither of the asymptomatic parents carries the mutation, confirming the de novo occurrence of the mutation.
fgene-14-1208673-g001.jpg
PMC10485270_01_fgene-14-1208673-g001.jpg
F1
There are no similar complaints in the family and no previous disease history (Figure 1A).
PMC10485270_02
PMC10485270_03