PMC5742908_01
Fundus photograph of the left eye showing central exudation and intraretinal hemorrhages in the temporal macula.
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Fundus examination of the left eye showed intraretinal hemorrhages and exudation with associated edema centrally (Figure 1).
Wide-field fluorescein angiography of the left eye highlighting numerous microaneurysms and associated leakage within the macula (a) and peripheral capillary dropout (b).
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Wide-field fluorescein angiography of the left eye revealed central microaneurysms with leakage and capillary nonperfusion peripherally (Figure 2).
(a) Initial OCT of the macular with intraretinal edema and subretinal fluid. (b) Persistent macular edema despite initial peripheral laser photocoagulation and three intravitreal bevacizumab injections at 3 months. (c) Resolution of central macular edema at 12 months after repeated intravitreal aflibercept injections.
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Spectral domain optical coherence tomography (OCT) initially demonstrated macular edema and subretinal fluid (Figure 3(a)). Despite a series of three monthly intravitreal bevacizumab injections, macular edema persisted at 3 months (Figure 3(b)). Additional focal laser to noncenter involving macular edema was also applied at month 10; however, the improvement of macular edema on OCT was most pronounced following two additional monthly injections of intravitreal aflibercept (Figure 3(c)).