PMC5835247_01
Glomerulus from July 2016 kidney biopsy showing segmental fibrinoid necrosis and a cellular crescent.
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fig1
A renal biopsy revealed a pauci-immune necrotizing and crescentic glomerulonephritis (Figure 1) suggestive of MPO-ANCA-associated nephritis.
Photomicrographs from autopsy. (a) Liver (40x) with focal necrosis and microabscesses. (b) Liver (100x) with normal bile ducts without inflammation. Inset (400x): phagocytosis of blood cells by Kupffer cells. (c) Bone marrow (40x) displays appropriate cellularity for age with a slight reactive shift. Inset (400x): hemophagocytosis in the bone marrow. (d) Spleen (40x) with sinusoidal expansion by macrophages with abundant hemophagocytosis (inset: 400x).
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fig2
The same findings were present on the liver at autopsy, along with hemophagocytosis in the bone marrow and spleen (Figure 2).