PMC9992714_01
Case 1 patient achieved PR after the treatment. (A-E) CT images showing the patient's baseline disease (left panel) and response to treatment (right panel). (A, B) Diffuse thickened gastric wall significantly thinned after the treatment. (C) Pleural effusion indicated the left lung metastasis, and it was absorbed after the treatment. (D) Virchow's nodes were slightly reduced in size. (E) Retroperitoneal lymph nodes shrunk after the treatment. (F-H) Dynamic monitoring of Fbg level, FDP, platelet counts, PT, and APTT, suggested that the coagulation function was restored. (I) Dynamic monitoring of tumor markers during the treatment. (J) Timeline of the treatment. The patient discontinued PD-1 inhibitors on 29 June and received chemotherapy only, and DIC relapsed after 2 months. PR, partial response; Fbg, fibrinogen; FDP, fibrin degradation product; PT, prothrombin time; APTT, activated partial thromboplastin time.
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After three courses of treatment, the patient achieved partial response ( Figure 1 ), according to the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST).
PMC9992714_02
Case 2 patient achieved PR after the treatment. (A-D) The outcomes of CT scans at baseline (left panel) and 2 months after the treatment (right panel). (A) Thickened gastric wall thinned after the treatment. (B) Retroperitoneal lymph nodes significantly shrunk compared with the baseline. (C) The uneven density of the lumbar vertebrae was kept stable during the treatment. (D) Virchow's lymph nodes are slightly reduced in size. (E) The decline in the tumor marker level suggested that the treatment was effective. (F) Anemia remission and coagulation function were restored according to the dynamic monitoring of PLT counts and HGB level. PLT counts temporarily increased in the over-normal range on 8 March but finally returned to the normal range. (G) Timeline of the treatment. PLT, platelet; HGB, hemoglobin.
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The patient achieved partial response after 2 months ( Figure 2 ).