PMC4899666_01
49-year-old female with granular-cell tumor of the abdominal wall. Ultrasonography of left upper quadrant subcutaneous fat demonstrating a 2.2 cm, slightly ill-marginated hypoechoic mass in the subcutaneous tissue.
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Ultrasound examination revealed an irregular soft-tissue mass in the left subcostal subcutaneous tissue, measuring 2.2 cm in greatest dimension (Fig. 1).
49-year-old female with granular-cell tumor of the abdominal wall. Magnetic resonance images (A, T1, axial, fat-suppressed, post-IV contrast; B, T1, coronal, fat-suppressed, post-IV contrast; C, T1, axial precontrast; D, T2, sagittal) showing the enhancing soft-tissue mass in left upper quadrant subcutaneous fat (dimensions, 2.2 x 2.2 x 2.8 cm).
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A chest-wall MRI revealed a nonspecific enhancing soft-tissue mass within the subcutaneous fat in the same site, measuring up to 2.8 cm in greatest dimension (Fig. 2).
49-year-old female with granular-cell tumor of the abdominal wall. Gross appearance of the granular-cell tumor with cut surface, showing a relatively well-demarcated, solid pale yellow mass.
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All margins were negative on gross examination, with the closest margin 5 mm from the mass to the cut edge (Fig. 3).
49-year-old female with granular-cell tumor of the abdominal wall. Hematoxylin and eosin stain showing granular-cell tumor composed of large polygonal cells with granular cytoplasm, separated by slender fibrous tissue (A, x 100 magnification; B, x 600 magnification).
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The tumor measured 2.1 cm in greatest dimension, and was composed of large polygonal cells with granular-appearing cytoplasm, separated by fibrotic tissue (Fig. 4).
49-year-old female with granular-cell tumor of the abdominal wall. The granular cytoplasm expresses S-100 protein (S-100 immunohistochemical stain, x200).
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The granular cytoplasm stained strongly for S-100 protein (Fig. 5).