PMC4696675_01
Brain MRI of the proband at the age of 14 months (A), 28 months (B), and 4 and a half years (C,D).. After the initial normal findings (A), note the progressive cerebellar atrophy mainly involving the complete vermis (indicated by the arrows in B, C). The hemispheres, displaying prominence of the cerebellar folia, were eventually affected (D).
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Subsequent studies performed at the ages of 28 months and 4 years showed a conspicuous and progressive, predominantly vermian, cerebellar atrophy with no involvement of other brain areas (Fig 1).