PMC2939476_01
(a) Nodular stage Kaposi's sarcoma containing compact keratin layer in the epidermis (Hematoxylin-Eosin [H-E], x40). (b) Lamellar keratin accumulation on the epidermis at the surface of the lesion (H-E, x100). (c) Neoplastic proliferation consisting of fusiform cells and extravasated erythrocytes in nodular stage Kaposi's sarcoma (H-E, x200).
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fig1
A cutaneous horn structure composed of compact keratin was observed on the epidermis at the tumour surface (Figures 1(a)-1(c)).
CD31 (a) and HHV-8 (b) immunoreactivity in neoplastic spindle cells ((a)-(b): AEC-DAB, x400).
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fig2
The immunohistochemical analysis showed a positive cytoplasmic reaction with lymphovascular endothelial markers (CD31, CD34, and D2-40) and a positive nuclear reaction with human herpesvirus-8, latent nuclear antigen-1 (HHV-8, LNA-1) in the neoplastic cells (Figure 2).