PMC3681400_01
Evolution of serum creatinine in relation to important clinical events and colimycin treatment.
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Inflammatory parameters decreased and plasma creatinine reached stable levels (Figure 1). Antibiotics were left unchanged except for a dose reduction of meropenem (2 g q12h) because of a slight postoperative plasma creatinine increase (Figure 1).
Colistin base concentrations in plasma and ultrafiltrate during continuous venovenous hemofiltration (CVVH).. Notes: Ultrafiltrate: plain line; Plasma: dotted line.
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The initial plasma colistin concentration of 8.06 mug/mL (peak level) fell within 12 hours to below 1 mug/mL (Figure 2, dotted line). The maximal colistin concentration (0.46 mug/mL) in the ultrafiltrate was attained only after 3 hours (Figure 2, plain line).