PMC8323073_01
Axial (
A) and sagittal (
C) Short-TI Inversion Recovery (STIR) magnetic resonance imaging (MRI) images of the bilateral lower extremities demonstrate edematous signal involving the left lower extremity vastus medialis, vastus intermedius, soft tissues of the popliteal fossa, and overlying subcutaneous soft tissues. Axial fat-saturated T1-weighted postcontrast MRI of the bilateral lower extremities (
B) demonstrates associated enhancement of the vastus medialis, vastus intermedius, and soft tissues of the popliteal fossa. Findings are compatible with myositis with overlying cellulitis.
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Magnetic resonance (MR) imaging of her lower extremity demonstrated myositis and fasciitis involving the soft tissues of the distal left thigh, but no abscess ( Figure 1A-C).
Skin punch biopsy demonstrates acute suppurative panniculitis with suppurative necrosis (20x, Hematoxylin and Eosin).
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A lesion on her back was biopsied and demonstrated acute suppurative panniculitis and suppurative necrosis ( Figure 2).
Axial (
A) and sagittal (
B) fat-saturated volumetric interpolated breath-hold examination (VIBE) postcontrast magnetic resonance imagery (MRI) images of the thoracic spine demonstrate multilevel thoracic osteomyelitis and discitis with associated epidural and paravertebral abscesses.
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MR imaging of her spine demonstrated enhancement of T9-T11 with an epidural abscess ( Figure 3A-B).
Decreased cytokine response to toll-like receptor (TLR) agonists:
A) TNF alpha,
B) IL-1b, and
C) IL-6 was measured following peripheral blood mononuclear cell (PBMC) stimulation with PAM3CSK4 (TLR2 and TLR1), zymosan (TLR2 and TLR6), Poly (I:C) (TLR3), flagellin (TLR 5), CLO97 (TLR7 and TLR8), and LPS (TLR4).
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Laboratories) using peripheral blood mononuclear cells ( Figure 4). LPS-induced CD62L shedding in neutrophils is an additional potential screening test for