PMC7132166_01
Pathology from Patient #1 Autopsy.. Heart: H&E of myocyte hypertrophy and thickened cardiac vessels with pink amorphous material (A). Congo Red with perivascular apple-green birefringent amyloid deposition in cardiac vessels (B). Protein P immunohistochemistry with patchy staining of amorphous material within vessel walls (C). Lung: H&E showing a vessel with thickened walls containing pink amorphous material (D). Congo Red with perivascular apple-green birefringent amyloid deposition (E). Amyloid A immunohistochemistry showing strong perivascular staining (F). Kidney. H&E showing a large deposit of pink amorphous material (G) and a vessel with thickened walls containing pink amorphous material (H). Congo Red with perivascular apple-green birefringent amyloid deposition (I). Stomach (J), Large Bowel (K), Bladder (L), and Prostate (M). H&E showing vessels with thickened walls containing pink amorphous material. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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Autopsy was performed which revealed diffuse, systemic amyloidosis with predominantly serum AA protein involving the pulmonary, cardiovascular, gastrointestinal, and endocrine system (Fig. 1).
PMC7132166_02