PMC3259023_01
Ultrasonography revealed a well-circumscribed homogeneous hypoechoic mass 5 cm in diameter.
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Ultrasonography revealed a well-circumscribed homogeneous hypoechoic mass 5 cm in diameter (Figure 1).
Mammography in May 2011 revealed well-defined, rounded, and oval masses, some with coarse calcifications and the largest being 5 cm in diameter (white arrow).
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In 2011, one of the masses in the left breast changed in diameter from 3 cm on mammography done in February 2010 (Figure 3) to 5 cm diameter in mammography done in May 2011 (Figure 2).
Mammography in February 2010 revealed well-defined, rounded and oval masses, some with coarse calcifications the largest being 3 cm in diameter (white arrow).
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In 2011, one of the masses in the left breast changed in diameter from 3 cm on mammography done in February 2010 (Figure 3) to 5 cm diameter in mammography done in May 2011 (Figure 2).
Within the typical fibroadenoma, irregular groups of invasive carcinoma cells are seen in the stroma (arrows). Hematoxylin and eosin (HE) x50.
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Microscopy revealed fibroadenoma with many foci of invasive duct carcinoma (Figure 4).
Nests of invasive carcinoma (arrow). Hematoxylin and eosin (HE) x100.
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Staining of the myoepithelium around tumoral foci with CD10 and actin was negative (Figures 5 and 6).
Myoepithelial cells are absent in invasive carcinoma (black arrow), and myoepithelial cells are preserved in fibroadenoma structures (white arrow). Calponin immunostain x100.
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Staining of the myoepithelium around tumoral foci with CD10 and actin was negative (Figures 5 and 6).