PMC3354386_01
Macroscopy of the right ovarian tumor: a papillary, polypoid component protrudes into a cystic space.
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F1
The outside of the cyst was smooth but the inside was partly covered with several papillomatous vegetations (Fig. 1).
Proliferating Brenner tumor of the right ovary: a and b: Hematoxylin and eosin staining showing the papillomatous, without infiltrating configuration with low grade cytological features (Magnification x40 and x200); c and d: Immunohistochemistry showing positivity of the tumor cells for cytokeratin 7 (Magnification x40 and x200).
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F2
Microscopic examination (Fig. 2a, b) showed a cyst with endoluminal papillae covered by transitional epithelium, practically indistinguishable from the urinary bladder tumors (Fig. 3a, b), without stroma infiltration. Immunohistochemical studies demonstrated that the ovarian Brenner tumor and the multiple recurrent urothelial carcinoma of bladder stained diffusely positive for cytokeratin 7, but both of these tumors were negative for cytokeratin 20 (Fig. 2c, d and Fig. 3c, d).