PMC4336666_01
Multiple smooth, round, and pinkish papules on the skin of the face near the angle of the mouth.
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F1
The surface of the lesions appeared smooth, round, blanched and pinkish with a dimple in the middle, and they were soft in consistency and non-tender (Figure 1).
Gross picture of the excised specimens.
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F2
Under local anesthesia, the two larger lesions were surgically excised, and the biopsied tissues were fixed in 10% formalin and sent for histopathological examination (Figure 2).
Lobular hyperplasia of epidermis resulting in a cup shaped invagination into the dermis (H and E, x4).
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F3
Microscopic examination of the excised tissue by routine hematoxylin and eosin (H and E) staining revealed hyperplastic epidermis in the form of lobules invaginating into the dermis (Figure 3).
Henderson-Paterson/molluscum bodies appearing eosinophilic in the spinous layer and basophilic in the granular layer (H and E, x20).
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F4
Progressing toward the center of the lobule, the spinous cells showed cytoplasmic vacuolization and large intra-cytoplasmic, basophilic viral inclusions called Molluscum bodies or Henderson-Paterson bodies, which compress the keratinocyte nucleus (Figure 4).
Special stains used to demonstrate molluscum bodies; (a) Molluscum bodies appearing basophilic with gram stain (x10), (b) molluscum bodies appearing eosinophilic with giemsa stain (x10), (c) molluscum bodies appearing eosinophilic with papanicolaou stain (x10).
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F5
Along with H and E, special stains such as Gram's, Giemsa, and Papanicolaou (Figure 5) were also done to demonstrate the viral inclusion bodies within the host cell.