PMC5224420_01
Pathological and immunohistochemical features of the follicular dendritic cell sarcoma (FDCS). The Hematoxylin and Eosin staining reveal diffuse proliferation of spindled cells with nuclear atypia (arrows, A to C, x40). Eosinophilic cytoplasm with indistinct cytoplasmic borders and vesicular nuclei of the spindled cells are shown (Bx200, arrows). Scattered small lymphoid cells and perivascular (arrow) clusters of small lymphocytes (Cx40) are also marked. Immunohistochemistry demonstrates positivity of tumor cells for CD21 (Dx100), CD35 (Ex100), vimentin (Fx100), S-100 (Gx100), CD3 (Hx100) and CD1a (arrows).
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F1
Needle biopsy of the lymph node and pathology confirmed a diagnosis of FDCS (Figure 1). The Hematoxylin and Eosin staining revealed diffuse proliferation of spindled cells with nuclear atypia (Figure 1A) and eosinophilic cytoplasm (Figure 1B). Scattered small lymphoid cells and perivascular (arrow) clusters of small lymphocytes (Figure 1C) are also marked. Immunohistochemistry demonstrates positivity of tumor cells for CD21 (Figure 1D), CD35 (Figure 1E), vimentin (Figure 1F), S-100 (Figure 1G), CD3 (Figure 1H) and CD1a (not shown) while negativity for EMA, CK, CD20, lysozyme, MPO, CD34, CD30, and HMB45 (not shown).