PMC7250377_01
A dark-red nodule with extended purpura on the right femur with prominent lymph edema (a). Irregularly anastomosing vascular channels lined by single layers of enlarged, atypical endothelial cells that existed between the collagen bundles (H&E staining) (b). Immunohistochemical staining for case 1: IL-23 (c) and IL-17 (d).
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PMC7250377_01_cro-0013-0462-g01.jpg
F1
During her initial visit, physical examination revealed a dark-red nodule with extended purpura on the right femur together with prominent lymph edema (Fig. 1a). Histologically, these were irregularly anastomosing vascular channels lined by single layers of enlarged, atypical endothelial cells that existed between the collagen bundles (Fig. 1b). Moreover, a substantial number of IL-23-producing cells (Fig. 1c) as well as IL-17-producing cells (Fig. 1d) were detected at the edge of the tumor mass.
PMC7250377_02
Multiple dark-red nodules with extended purpura on the left femur with prominent lymph edema (a). Irregularly anastomosing vascular channels lined by single layers of enlarged, atypical endothelial cells that existed between collagen bundles with prominent apoptotic cells (b). Immunohistochemical staining for case 2: IL-23 (c) and IL-17 (d).
cro-0013-0462-g02.jpg
PMC7250377_02_cro-0013-0462-g02.jpg
F2
During her initial visit, physical examination revealed multiple dark-red nodules with extended purpura on the left femur with prominent lymph edema (Fig. 2a). Histologically, these were irregularly anastomosing vascular channels lined by single layers of enlarged, atypical endothelial cells that existed between the collagen bundles with prominent apoptotic cells (Fig. 2b). Moreover, substantial numbers of IL-23-producing cells (Fig. 2c) as well as IL-17-producing cells (Fig. 2d) were detected at the edge of the tumor mass.