PMC8724197_01
(A) First CT: enlarged lymph nodes (a) 1 year later CT: extensive lymph node enlargement (B) Fibroscopy: numerous nodular protrusions (C) Lymph node biopsy: EBV-associated lymphoproliferative lesions (EBER+) (D) Sanger sequencing images before transplantation (d) Sanger sequencing images after transplantation.
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Figure 1A ). Fibreoptic bronchoscopy revealed a large number of scattered nodular protrusions throughout the trachea and knuckle ( Figure 1B ). EBV-associated lymphoid hyperplastic lesions (EBER+) confirmed by cervical lymph node biopsy ( Figure 1C ). Whole-exome sequencing showed that the patient had a heterozygous mutation (c.3061 G>A p.E1021K) in the PIK3CD gene ( Figure 1D ), and the family genealogy verified that both parents were normal. Figure 1a ). Final cervical lymph node biopsy suggested aggressive lymphoma of the lymph nodes, consistent with plasmablastic lymphoma; IgHV-FR1 (-), IgHV-FR2 (-), IgHV-FR3 (-), IgK-Vk-Jk (+), IgK-Vk-Kde+INTR-Kde (+). Thankfully, this was a successful transplant and the patient was genetically negative at the 1 month post-transplant review ( Figure 1d ).