PMC6474392_01
MRI pre (a,d,g) and post Vemurafenib (b,c,e,f,h,i) coronal T2w (a-f) and sagittal Gd T1w (g-i) images show best response after 6 months (b,e,h) and stable disease after 32 months (c,f,i).
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F1
Testosterone basal level was 54.5 ng/dL, PRL, beta-HCG, DHEAS and thyroid function were all normal. These results confirmed the suspect of an early puberty of central origin and a brain Magnetic Resonance Imaging (MRI) was then performed. The brain imaging showed diffused pathological tissue, extending from the left diencephalic region and involving the cerebral peduncle caudally, the basal ganglia region cranially (globus pallidus, putamen and posterior arm of the internal capsule), the outer capsule laterally, the temporo-mesial cortex and subcortical white matter, which extended deeply to the anterior portion of the temporal lobe, to the optic chiasm and bilateral retrochiasmatic tract (Figure 1).
Pleomorphic Xanthoastrocytoma. (A,B) Hematoxylin&Eosin staining shows a marked cellular pleomorphism, with the coexistence of several cell types. (C) Strong positivity for GFAP in immunohistochemistry. (D) Positivity for BRAF V600E in immunohistochemistry.
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