PMC7184850_01
Computed tomography findings at the first diagnosis. Para-aortic lymph nodes were enlarged (arrows). a Sagittal plane. b Coronal plane.
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F1
Computed tomography (CT) scans showed an enlarged uterus and enlarged lymph nodes, including the para-aortic lymph nodes (Fig. 1).
Histological findings in the uterine cervix. a, b A prevalent solid pattern composed of small cells with hyperchromatic nuclei may be seen. HE. a x100. b x400. Scale bars, 100 mum. c Immunohistochemical staining for CD56. x400. Scale bar, 100 mum. d Immunohistochemical staining for chromogranin A. x400. Scale bar, 100 mum.
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F2
Microscopic examination (Fig. 2a, b) revealed a prevalent solid pattern composed of small cells with hyperchromatic nuclei. On immunohistochemical analysis, CD56 (Fig. 2c) and chromogranin A (Fig. 2d), which are specific to neuroendocrine tumors, were positive.
Computed tomography (CT) findings. a The size of the para-aortic lymph nodes was increased (arrow) at 3 months after etoposide + cisplatin therapy. Because of the lowering of renal function, only plain CT was successful. b The para-aortic lymph nodes have diminished (arrow) at 18 months after paclitaxel, carboplatin, and bevacizumab combination therapy.
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F3
At 3 months after chemotherapy, her NSE level had increased, and CT scans showed an increase in the size of the para-aortic lymph node lesions (Fig. 3a), for which recurrence was diagnosed. CT scans revealed that the para-aortic lymph node lesions had diminished (Fig. 3b) and the patient's NSE level had normalized.