PMC8714887_01
Colonoscopic changes in the patient. (A) The terminal ileum was covered with white moss with a large and flaky ulcer accompanied by erosion. (B) The mucosa was hyperemic and edematous, with a perforated intestinal wall with a diameter of ~1.5 cm. (C) Scattered inflammatory polypoid changes were observed in the mucosa around the ileocecal valve mouth, without erosion or ulcer, whereas the morphology of the ileocecal valve was deformed. (D) No abnormalities were observed in the mucosa of the terminal ileum.
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F1
He was admitted to the hospital again and underwent electronic colonoscopy (Figures 1A,B) and pathological examination (Figures 2A,B), whereby Crohn's disease (CD) was diagnosed.
Histopathological changes in the patient. (A) The mucosal tissue of the ileocecal junction was denatured and necrotic, with ulcerative changes. (B) Neutrophils accumulated in the lumen of the gland with chronic inflammation, and a crypt abscess was seen (arrow). (C) A few neutrophils were seen infiltrating the mucosa of the transverse colon. (D) No obvious abnormality was observed in the intestinal crypt of the ileocecal mucosa.
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F2
He was admitted to the hospital again and underwent electronic colonoscopy (Figures 1A,B) and pathological examination (Figures 2A,B), whereby Crohn's disease (CD) was diagnosed.
Ocular fundus changes in the patient. (a) No obvious abnormality was observed in the left fundus. (b) The cornea of the right eye was deformed, the anterior chamber was clear, the crystal membrane was white and cloudy, the intraocular lens was normal, the optic papilla was pale, and the macular area was yellow and disordered (C/D = 0.7).
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F3
Nevertheless, the anterior chamber was still clear, the crystal membrane was white and cloudy, the intraocular lens was normal, the optic papilla was pale, and the macular area was yellow and disordered (C/D = 0.7) (Figure 3).
Magnetic resonance venography (MRV) changes in the patient. (A) There were many banded filling defects in the superior sagittal sinus (arrow). (B) A few filling defects were seen in the left transverse sinus (arrow). (C) The superior sagittal sinus was slightly narrowed, and the margin was rough (arrow). No obvious intracranial venous thrombosis was observed. (D) The left transverse sinus was slightly thin (arrow).
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F4
No abnormal signal shadow was observed in the brain parenchyma, ventricle, brainstem, or cerebellum (Figures 4A,B).