PMC10182764_01
Clinical image of physical finding. (A) Ocular hypertelorism and left eye ptosis. (B) Webbed neck. (C) Scoliosis.
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However, during physical examination, we discovered some abnormalities, such as ocular hypertelorism and left eye ptosis (Figure 1A), webbed neck (Figure 1B), vertebrae scoliosis (Figure 1C), and a lack of pubic hair.
Histopathological examination from hyperpigmented macules on right arm showed melanocytes deposition on basal layer of epidermis.
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The histopathological analysis of hyperpigmented macules from the right arm revealed a greater number of melanocytes in the epidermis' basal layer, elongated epidermal rete ridges, mild inflammatory cells infiltrate on the upper dermis, dilation of blood vessels, and no tumor cells (Figure 2).
Comparison between skin manifestation before and after two sessions of treatment. (A) Hyperpigmented macules on right cheek. (B) Improvement on right cheek skin lesions after two sessions of treatment.
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Improvement was observed in terms of skin tone brightness as assessed using spectrophotometry (Figure 3A and B).