PMC8559632_01
Sonography of left breast. A hypoecho mass with microcystic component was seen in retroareolar site
cjim-12-444-g001.jpg
PMC8559632_01_cjim-12-444-g001.jpg
F1
Sonography showed lobulated hypoecho mass with microcyctic areas measuring 20x17 mm at 3o'clock beside areol (Fig 1).
Gross picture shows tan-brown firm mass with multiple cyst formation
cjim-12-444-g002.jpg
PMC8559632_01_cjim-12-444-g002.jpg
F2
On gross examination, the surgical margins are free from tumoral cells and nipple was retracted (fig 2).
Microscopic sections show several cystic areas filled by mucinous secretion and lined by papillary and cribriform neoplasm
cjim-12-444-g003.jpg
PMC8559632_01_cjim-12-444-g003.jpg
F3
Microscopically, neoplastic tissue was seen, composed of dilated ducts, filling by papillary projections, cribriform and fused glands, lined by mild to moderate atypical cells with scattered mitoses and without distinct, myoepithelial layer mostly floating in mucinous lakes with invasion to surrounding stroma (figure 3).
In immunohistochemistry staining for A) Estrogen Receptors (10x), B) Estrogen Receptors (40x); tumoral cells show moderate to intense nuclear positivity. C) Progesterone receptors (10x), D) Progesterone receptors (40x); tumoral cells show weak nuclear positivity
cjim-12-444-g004.jpg
PMC8559632_01_cjim-12-444-g004.jpg
F4
Immunohistochemistry profile showed positive estrogen and progesterone receptors and negative for HER2 (figure 4).