PMC5201311_01
Percent positivity of HPV16 variant by 5-year age intervals.. The figure shows the percentage of HPV16 infections as a whole and as segregated by lineages D (D2 and D3) and A (A1/2) based on 5-year age intervals for all CC patients (n = 462). The decrease in HPV16 and D2 percent positivity with patient age to the 51-55 year-old interval were statistically significant (p < 0.05, Spearman correlation). The HPV16+ plot has already been published in a previous paper, but it was included as a reference for the trend of HPV16 variants.
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PMC5201311_01_pone.0169315.g003.jpg
pone.0169315.g003
To investigate whether the different components of the HPV16 curve were associated with specific variants, the trends in variant percentages were analyzed by considering 5-year intervals (Fig 3).
PMC5201311_02
PMC5201311_03