PMC6358352_01
(A) Histopathology-nasal clear cell carcinoma H&E (magnification x400), (B) Ki-67 (index30%), (C) CD10 (+), (D) CA9 (+), (E) PAX-8 (+), (F) Vimentin (+), (G) EMA (+), (H) AE1/AE3 (+).
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F1
CA 9, CD 10, EMA, and Ki-67 (Fig. 1), while SMA, Syn, P 63, CD 34, CgA, HMB 45, and S-100 were negative, which indicated the nasal metastatic tumor had a renal origin. Combination of imaging and histological examination, the patient was diagnosed as CCRCC and nasal metastatic tumor.
(A) A solitary nasal cutaneous nodule as big as a horsebean. (B) Quickly shrinkage of nasal metastatic tumor after 8-week treatment with axitinib.
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F2
The nasal metastasis shrinkage was observed after 8-week treatment with initial dose of 5 mg twice a day (Fig. 2) and the primary tumor was stable.