PMC1192792_01
Liver biopsy contains numerous neoplastic elongate cells consistent with malignant melanoma infiltration.
1471-2407-5-67-1.jpg
PMC1192792_01_1471-2407-5-67-1.jpg
F1
Autopsy revealed >80% liver infiltration by melanoma (Figure 1), a diagnosis verified by an immunohistochemical phenotype of S-100 and HMB-45 positive cells (Figure 2).
Immunohistochemistry of the liver. S-100 antibody stains malignant melanocytes with a brown chromogen (diaminobenzidine). Rare negative cells (blue due to hematoxylin counterstaining) are intact hepatocytes.
1471-2407-5-67-2.jpg
PMC1192792_01_1471-2407-5-67-2.jpg
F2
Autopsy revealed >80% liver infiltration by melanoma (Figure 1), a diagnosis verified by an immunohistochemical phenotype of S-100 and HMB-45 positive cells (Figure 2).