PMC8606537_01
Lipid storage in quadriceps femoris muscle biopsy. H&E stain revealed intracytoplasmic vacuoles appearing in most fibers of patient 2 (A, magnification x 400) and patient 3 (B, magnification x 200). ORO stain demonstrated abnormal accumulation of lipid droplets in muscle tissue of patient 2 (C, magnification x 400), and of patient 3 (D, magnification x 60). The electron microscopic ultrastructural muscle fiber study reveals the substantial deposition of lipid droplets between myofibrils in patient 2 (E, magnification x 3,000) and in patient 3 (F, magnification x 1,500).
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F1
Here, we used patients 2 and 3 as representative samples in Figure 1.