PMC6671878_01
- A - Endoscopic view of a sessile 0.3 cm LCH polyp in the sigmoid colon; B - Endoscopic view of an ulcerated and infiltrated 0.5 cm LCH polyp in the cecum; C - Photomicrography of a submucosal LCH nodule with central necrosis and ulceration (H&E, 100x); D - Photomicrography of LCH destructive infiltration of colonic crypt (H&E, 400x); E - CD1a immunostaining of infiltrative lesion showed in (D) (400x); F - CD207 immunostaining of the same lesion in (D) (400x).
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A previously healthy, nonsmoking 48-year-old male was referred for routine screening colonoscopy, which revealed two sessile, smooth, firm and yellowish LCH polyps in the sigmoid colon, measuring 0.2 and 0.3 cm (Figure 1A). A third colonoscopy after 28 months of follow-up found a submucosal 0.5 cm infiltrated and ulcerated LHC polyp in the cecum, close to the ostium of the appendix (Figure 1B). The three lesions were predominantly submucosal and showed areas of central necrosis (Figure 1C). The cecal polyp showed mucosal infiltration (Figure 1D) and ulceration. Immunohistochemical analysis of the lesions showed strong and diffuse staining for CD1a (Figure 1E) and CD207 (Figure 1F).