PMC6151220_01
(a) Jumping translocations of 1q observed in the three patients. The jumping translocation in each cell lineage is shown inside a circle. Arrow points to an additional rearrangement evolved in a cell lineage. (b) Epigenetic alterations in the formation of jumping translocations of 1q. Hypomethylation of 1q12 pericentric heterochromatin induced chromatin decondensation, triradial formation, and break-off of 1q donor segment. Loss of telomeric function by variant telomeric repeats and shortened telomeres produced instable recipient chromosomes. The successive fusions between break-off donor segment and recipient chromosomes resulted in clonal abnormalities with cell linages sharing gains of donor chromosome segment.
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fig1
The chromosome patterns of jumping translocations of 1q are shown in Figure 1(a).
Patterns of donor and recipient chromosomes in jumping translocations of 1q of MDS and AML patients.
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Figure 2. For a total of 110 cell lineages from these 33 cases, the cell lineages with jumping translocations of 1q in a patient ranged from two to ten, with an average of about three cell lineages.