PMC6313995_01
Photomicrographs: lesion with papillary appearance showing exophytic projections of epithelial proliferation with benign appearance (a), transition zone of malignant neoplasm in the right vocal fold (b), well-differentiated SCC (c), dotted brown nuclei showing positive CISH result for high-risk HPV (16/18) in LP (d), and in SCC (e).
CRIOT2018-4362162.001.jpg
PMC6313995_01_CRIOT2018-4362162.001.jpg
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This epithelium exhibited projections towards the connective tissue and was infiltrated into the connective tissue, forming islands and strands of malignant epithelial cells (Figure 1). The epithelium was found with digitiform projections and fibrovascular connective tissue centers containing mononuclear inflammatory infiltrate (Figure 1(a)). A transitional zone was found in this biopsy, where the atypical epithelium protrudes exophytically with a digitiform aspect (Figure 1(b)). Atypical mitoses and areas of necrosis were also found (Figure 1(c)). Both lesions showed a positive result in CISH for high-risk HPV types 16 and 18 (Figures 1(d) and 1(e)) and negative for low-risk HPV types 6 and 11.