PMC3390923_01
Anatomy of 1846 and healthy comparison 3608 based on high-resolution T2-weighted structural MRI scans. Panel A uses three-dimensional models of traced structures from 1846 (see Fig. 1) and planar sections to illustrate the location of the slices shown in panels BD. In panel B, sagittal sections reveal the extensive atrophy of 1846's left hippocampus along its entire length (left column). The right hippocampus is less compromised (right column). In panel C, successive coronal sections illustrate hippocampal anatomy of the anterior hippocampal head (top row), the posterior hippocampal head at the uncal apex (middle row), and the hippocampal body caudal to the uncal apex (bottom row). At bottom right, 3608's right hippocampus contains enough detail for identification of several hippocampal subfields. In panel D, axial sections reveal the severe atrophy of 1846's left hippocampus and the corresponding enlargement of the inferior horns of the lateral ventricles. Common abbreviations for panels BD: A, anterior; P, posterior; R, right; L, left; h, hippocampus; hh, hippocampal head; hb, hippocampal body; ht, hippocampal tail; a, amygdala; v, inferior horn of the lateral ventricle; mb, mammillary body/bodies; sub, subiculum; ca1, cornu ammonis-1; dg/ca4, dentate gyrus and cornu ammonis-4; fim, alveus/fimbria.
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F2
Anatomically, the right hippocampi of the two patients are strikingly similar, showing relatively circumscribed lateral reductions in volume, but 1846's left hippocampus is markedly more atrophic than RB's (see Neuroanatomy section and Figure 2).