PMC4194013_01
Microscopic findings of the thyroid, lymph node, and lung tumors. In the primary thyroid lesion, the tumor cells exhibited a typical papillary structure (a), nuclear grooves (black arrow) and intranuclear cytoplasmic inclusion (white arrow) (b). The lymph node was diagnosed as metastasis of papillary thyroid carcinoma (c). There were multinucleated cells; however, no cellular atypia was observed within the lung tumor (d). Thyroglobulin was stained within the lung tumor (e). a-d H&E staining, e thyroglobulin staining
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Fig1
Histological analysis revealed tumor cells with a typical papillary structure, with nuclear grooves and intranuclear cytoplasmic inclusion, leading to a diagnosis of PTC (Fig. 1a, b). Excisional biopsy of one cervical lymph node was performed 2 years and 6 months after surgery and the histological diagnosis was metastasis of PTC (Fig. 1c). There were multinucleated cells in the surgical specimen, without cellular atypia, suggestive of anaplastic carcinoma (Fig. 1d). Furthermore, there were multinucleated cells, without cellular atypia inside the lung lesion (Fig. 1d), while immunostaining of thyroglobulin was positive within the lung tumor (Fig. 1e).
Microscopic findings (CA19-9 staining) of the thyroid, cervical lymph node, and lung tumors. The primary thyroid tumor (a) and cervical lymph node (b) were negative for CA19-9, whereas the lung tumor (c) was positive
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Fig3
Intense staining was observed in the cytoplasm of the pulmonary lesions with immunostaining of CA19-9, although there was no staining in the primary thyroid lesion or cervical lymph node metastasis (Fig. 3a-c).