PMC5917940_01
(A) Percutaneous liver biopsy with hematoxylin and eosin stain showing enlarged hepatocytes with cytoplasmic pallor, pink globules consistent with glycogen accumulation (white arrow), and prominent glycogenated nuclei (black arrow). (B) Diastase-periodic acid-Schiff stain with removed glycogen leaving empty-looking cytoplasm (white arrow) and nuclei (black arrow).
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F1
Increased hepatocyte glycogen was confirmed on a periodic acid-Schiff stain, and hepatocytes became "ghost cells" upon diastase digestion of the glycogen (Figure 1).
Trichrome stain demonstrating multifocal periportal scarring (black arrow) with periportal bridging fibrosis (white arrow).
CG-CGCR180018F002.jpg
PMC5917940_01_CG-CGCR180018F002.jpg
F2
Mild lobular inflammation with periportal and bridging fibrosis (F3 fibrosis) was also noted, which was an unusual finding for GH (Figure 2).