PMC2671966_01
Severe cholestasis with bile inside the hepatocytes and numerous bile casts in the
          canaliculi, predominantly in the pericentrilobular zone; small numbers of mononuclear
          cells and neutrophils infiltrate into the vicinity of the cholestasis (HE, x
          400)
14-le-0032f1.jpg
PMC2671966_01_14-le-0032f1.jpg
f1-14-le-0032
The liver architecture was intact           (Figure 1).
Evolution of alkaline phosphatase, gamma glutamyl transpeptidase (GGT), and total
          bilirubin; UNL: upper normal limit
14-le-0032f2.jpg
PMC2671966_01_14-le-0032f2.jpg
f2-14-le-0032
The         patient presented with slow and progressive improvement of all clinical and laboratory         parameters, with complete normalization of the bilirubin levels in 8 months, alkaline         phosphatase in 16 months, and GGT in 35 months (Figure 2).