PMC5912277_01
(a) Emaciation, muscle loss, unkept haircoat and alopecia. (b) Fragile thin inelastic skin. (c) Bilateral symmetrical alopecia, unkempt haircoat, and potbellied abdomen
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On physical examination, the cat displayed abdominal distension, fragile/thin skin and symmetrical bilateral alopecia predominantly affecting the thorax and limbs (Figure 1).
Home-generated serial blood glucose measurements before diabetic remission. The curves are shown in relation to glargine insulin dose modifications and days on trilostane treatment. All curves started at midday and finished at midnight
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However, given the persistence of clinical signs and the results of serial blood glucose evaluation (Table 1, Figure 2), the glargine dose was increased to 4 U q12h SC. Additionally, glycemic control improved, as demonstrated by subsequent resolution of diabetic signs, as well as serial blood glucose assessment (Figure 2).
Ultrasonographic appearance showing bilateral enlargement of the adrenal glands. (a) Left (L) adrenal longitudinal section (1.41 x 0.71 cm). (b) Left adrenal transverse (transv) section (0.68 x 0.88 cm). (c) Right (R) adrenal transverse section (0.76 x 1.01 cm). (d) Right adrenal longitudinal section (1.36 x 0.8 cm)
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Additionally, bilateral adrenomegaly was present on abdominal ultrasonography (US), further supporting this diagnosis (Figure 3).
(a) Weight and muscle mass gain, complete haircoat re-growth and re-pigmentation. (b) Loss of potbellied appearance and ventral abdominal haircoat re-growth
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Two months later (100 days after starting trilostane) the cat was reported to show no clinical signs of DM, demonstrated an increased weight of 3.4 kg, complete fur re-growth (Figure 4) and fair control of blood glucose concentrations.