PMC4333549_01
Fundus findings before and after intravitreal bevacizumab injection. At presentation, optic discs welling, macular edema, and peripapillary flame-shaped hemorrhages and hard exudates were present in both eyes (a). One month after intravitreal bevacizumab injection, the bilateral optic disc swelling and hard exudates were decreased (b). Three months (c). after the treatment, the optic disc swelling, macular edema and hard exudates decreased both eyes
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F1
Fundoscopic examination showed bilateral optic disc swelling, peripapillary retinal edema involving the macula and peripapillary flame-shaped hemorrhages with multiple hard exudates more with the right eye [Figure 1a]. One month after the treatment, visual acuity was 20/400 and 20/100 in her right and left eyes, respectively, and the bilateral optic disc edema and macular edema had resolved [Figures 1b and 3b]. Three months after the treatment, much of the hard exudates surrounding the fovea bilaterally were absorbed on fundus examination [Figure 1c].
Fluorescein angiography findings before and after intravitreal bevacizumab injection. At presentation, profuse fluorescein leakage from the optic disc and diffuse leakage from the capillaries along the vascular arcades were present in both eyes (a). One month after intravitreal bevacizumab injection, decreased leakage from the optic discs and the retinal vessels (b). Three months after the treatment, minimal fluorescein leakage occurred from the optic disc both eyes with macular area of nonperfusion of the right eye (c)
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F2
Fluorescein angiography (FAG) showed extensive fluorescein leakage from the optic disc and diffuse capillary leakage along the vascular arcades in both eyes [Figure 2a]. FAG showed minimal leakage from the optic discs bilaterally with macular area of nonperfusion of the right eye which might explain decreased right eye vision [Figure 2b].
Optical coherence tomography findings before and after intravitreal bevacizumab injection. At presentation, macular edema and subfoveal neurosensory detachments were noted both eyes. The central macular thickness (CMT) was 392 mm in the right eye and 874 mm in the left eye (a). One month after the treatment, CMT decreased to 193 mm in the right eye and 194 mm in the left eye (b). The CMT reduced to 144 mm in right eye and 193 mm in left eye with atrophic thinning of the fovea 3 months after the (c)
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F3
Optical coherence tomography (OCT) revealed bilateral marked macular edema and neurosensory detachment [Figure 3a]. One month after the treatment, visual acuity was 20/400 and 20/100 in her right and left eyes, respectively, and the bilateral optic disc edema and macular edema had resolved [Figures 1b and 3b]. Although she showed resolution of the bilateral macular edema, atrophic thinning of the fovea in both eyes was detected on OCT [Figure 3c].