PMC4750020_01
Mild focal atypia and increased mitotic rate are seen (100 x, hematoxylin & eosin).
gr1.jpg
PMC4750020_01_gr1.jpg
f0005
Pathology of the smaller uterine tumor showed a smooth muscle tumor with focal, mild, cytologic atypia, apoptotic cell necrosis and increased mitotic activity with up to 9 MF per 10 HPF (Fig. 1, Fig. 2) consistent with diagnosis of STUMP.
Stump is ER positive, p16 and p53 negative (immunoperoxidase, 200 x).
gr3.jpg
PMC4750020_01_gr3.jpg
f0015
Immunohistochemical staining for p53 and p16 was negative (Fig. 3).