PMC7333030_01
Transabdominal ultrasonography.
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On abdominal ultrasonography, the gallbladder measured 8.7 x 4.8 cm and was filled with necrotized mass and all edges of the gallbladder were clear except for the bottom (Figure 1).
Pathohistochemical profile. (a) Ligand: normal gallbladder mucosa. (b, c) H&E stain shows proliferation of spindle cells arranged in interlacing bundles, pronounced nuclear atypia, pleomorphism, and many atypical mitotic figures (x200 and x400, respectively). (d) SMA stain: the neoplastic cells show a strong cytoplasmic staining reaction (x200).
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fig2
On microscopy, the tumor consisted of diffuse proliferation of pleomorphic spindle to oval tumor cells with marked variation in size and shape and the presence of many abnormal mitoses and large hyperchromatic nuclei (Figure 2). Immunohistochemical investigations were strongly positive for smooth muscle actin (SMA) and desmin and negative for CK, CD117, and CD34 (Figure 2).