PMC2816287_01
Chest computed tomography shows diffuse micronodules and ground glass opacities in both lung fields.
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F1
During the 3 yr follow-up period, no significant change was found in pulmonary micronodular densities, but occasionally, GGO was found on chest CT with symptoms of dyspnea ATS grade II and fever (Fig. 1).
Histologic section shows numerous micronodules in the alveolar spaces (H&E, x1).
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F2
Histologic sections showed numerous micronodules in the alveolar spaces (Fig. 2). Mitotic figures were less than 2 per 10 high power fields.
Microscopically, nodules consist of short spindle cells arranged in ill-defined whorls. The tumor cells have bland nuclear features and eosinophilic cytoplasm (H&E, x200). Inset shows nuclear immunoreactivity for estrogen receptor (x400).
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F3
These nodules consisted of short spindle cells arranged in ill-defined whorls and the neoplastic cells had bland nuclear features and eosinophilic cytoplasm (Fig. 3). Immunohistochemically, these neoplastic cells showed strong nuclear staining for estrogen receptor (Novocastra, Newcastle, U.K., 1:100 dilution) (Fig. 3, inset) and progesterone receptor (Novocastra, 1:40 dilution), and diffuse cytoplasmic staining for CD10 (Novocastra, 1:40 dilution).