PMC6485059_01
Chronological relationships of antibiotic treatment, vitamin K1 administration, surgical procedures, and coagulation time fluctuation of the patient. APTT prolonged activated partial thromboplastin time, PBD post-burn day, PT prothrombin time
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Fig1
Broad-spectrum antibiotics, Meropenem  (1.0 g three times daily), was applied intravenously since PBD 3 as the empirical therapy for extensive burn patients and continued for ensured Pseudomonas aeruginosa-positive of the wound in this patient (Fig. 1). APTT improved to 47 s and came back to the normal range on PDB 39 along with normal value of coagulation factor II, VII, IX, and X (Figs. 1 and 4), even with combined usage of tigecycline (0.5 g three times daily) and fosfomycin sodium (4.0 g three times daily) intravenously, started on PBD 38, dealing with multi-resistant strain of Klebsiella pneumonia (tigecycline resistant). Another two operations were performed for grafting on PBD 40 and 52.
Daily maximal temperature and heart rate (HR) of the patient during his stay in hospital. PBD Post-burn day
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Fig2
Not until PBD 13 did the patient show the signs of infection, such as chill, high fever, wounds infiltration, delirium, and neutrocytosis (Figs. 2 and 3), while his hemodynamic status remained stable, all coagulation criteria within normal range.
Infection related indicators (blood cell count and Precalcitonin (PCT)) levels of the patient during his stay in hospital. PBD Post-burn day, PLT Platelet, WBC White blood cell
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Fig3
Not until PBD 13 did the patient show the signs of infection, such as chill, high fever, wounds infiltration, delirium, and neutrocytosis (Figs. 2 and 3), while his hemodynamic status remained stable, all coagulation criteria within normal range.
Coagulation factor level fluctuation of the patient before and during his treatment of hypocoagulation. PBD Post-burn day
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Fig4
APTT improved to 47 s and came back to the normal range on PDB 39 along with normal value of coagulation factor II, VII, IX, and X (Figs. 1 and 4), even with combined usage of tigecycline (0.5 g three times daily) and fosfomycin sodium (4.0 g three times daily) intravenously, started on PBD 38, dealing with multi-resistant strain of Klebsiella pneumonia (tigecycline resistant). Another two operations were performed for grafting on PBD 40 and 52.
Relationship between intravenous vitamin K1, meropenem, fosfomysin sodium, tigecycline, and levels of factors related to hypocoagulopathy. Meropenem, 1.0 g three times daily; tigecycline, 0.5 g three times daily; fosfomycin sodium, 4.0 g three times daily. PBD post-burn day
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Fig5
The patient was discharged on PBD 67 with all burn wounds recovered and no abnormality in coagulation status (Fig. 5).