PMC3420589_01
Photomicrograph of the preinduction chemotherapy of bone marrow showing diffuse infiltration by malignant cells.
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fig1
Flow cytometry of initial bone marrow biopsy (Figure 1) showed 27% myeloblast, positive for CD34, CD 117, HLA-DR and CD 33 and negative for CD14, and CD56 as well as 61% monoblast positive for CD14, CD11b,HLA-DR and CD64 and negative for CD34,CD 56 and CD117.
Low power photomicrograph of bone marrow showing areas of necrosis and nonnecrotic areas after G-CSF administration.
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fig2
Given mounting concern for identification of definitive etiology of profound leuckocytosis, a repeat bone marrow biopsy was done on day 21, which revealed hypercellular marrow with patchy myelonecrosis and 1% myeoblast 6.8% monocytes (Figure 2).