PMC5414488_01
(a) Scanner view shows the tumour cells in the lamina propria and in the submucosa and muscularis propria of the colonic wall (H&E x40 magnification). (b) High power view shows the morphology of the tumour cells in the lamina propria with preservation of the crypts (H&E x400 magnification). (c) High power view shows the tumour cells arranged in sheets in the submucosa and muscularis propria. The prominent intranuclear and intracytoplasmic inclusions can be noted (H&E x400 magnification).
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fig1
These tumour cells were seen in the lamina propria in between the preserved crypts and infiltrating the muscularis propria and beyond, but confined to the bowel wall (Figure 1(a)). The tumour cells had plasmacytoid morphology with marked pleomorphism and many intranuclear and intracytoplasmic inclusions (Figures 1(b) and 1(c)).
(a) High power view shows the tumour cells staining positive for vimentin (IH stain with haematoxylin counterstain x400 magnification). (b) High power view shows tumour cells are positive for CD138 (IH stain with haematoxylin counterstain x400 magnification). (c) High power view shows that tumour cells are positive for MUM 1 (IH stain with haematoxylin counterstain x400 magnification). (d) High power view shows that tumour cells are positive for CD56 (IH stain with haematoxylin counterstain x400 magnification). (e) High power view shows that tumour cells are positive for kappa light chain (IH stain with haematoxylin counterstain x400 magnification). (f) High power view shows that tumour cells are negative for Lambda light chain (IH stain with haematoxylin counterstain x400 magnification). (g) High power view shows the ki67 proliferation index in the tumour (IH stain with haematoxylin counterstain x400 magnification).
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fig2
The tumor cells were negative for the cytokeratins, lymphoid markers, and all mesenchymal markers except vimentin (Figure 2(a)). The plasma cell markers CD138, MUM-1, and CD56 were positive along with positivity for kappa light chain and negativity for Lambda light chain staining (Figures 2(b)-2(f)). Ki-67 proliferation index was 30% (Figure 2(g)).