PMC7276430_01
Timeline with CT scan and FEV1 evolution over time.
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PMC7276430_01_gr1.jpg
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In March 2014 (T0) (Fig. 1), because of a high risk of relapse, she received an allogenic hematopoietic stem cell transplantation (HSCT).
A) Lung CT-scan: "Crazy Paving" pattern with excavated subpleural lesion (circled) B) Explanted lung showing diffuse diffuse yellow cut surface and the fungal cavity (circled) C) Photomicrograph of pulmonary parenchyma: alveoli are filled by eosinophilic amorphous or finely granular material that is periodic acid-Schiff-positive. Haematoxylin and eosin stain (x100). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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High-resolution computed tomography (HRCT) showed a bilateral perihilar mosaicism with zones of ground glass attenuation in a "crazy paving" pattern (Fig. 2, panel A). At T0 + 45 months, because of worsening of PFT, appearance of a cavitary subpleural lesion on HRCT (Fig. 2, panel A (red circle)), and high levels of serum galactomannan, posaconazole was introduced for suspicion of a locally invasive pulmonary aspergillosis.