PMC5636907_01
(A) Endoscopic view of esophageal glycogenic acanthosis on EGD. (B) Small sessile fibroblastic polyp in the descending colon.
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F1
On esophagogastroduodenoscopy (EGD), glycogenic acanthosis was observed in the esophagus (Figure 1). On colonoscopy, 12 sessile polyps measuring 2-5 mm in diameter were seen in the transverse, descending, and sigmoid colon (Figure 1).
Hematoxylin & eosin stain demonstrating mucosal replacement by spindle cells without evidence of hyperplasia or dysplasia.
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F2
Entrapped crypts demonstrated slight reactive change, distinct from the inflammation typically observed with inflammatory fibroid polyps, and also showed no evidence of hyperplasia or dysplasia (Figure 2).
Negative immunohistochemical staining with (A) S-100, (B) epithelial membrane antigen, and (C) CD34.
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F3
On immunohistochemical staining, the spindle cells were negative for S-100, epithelial membrane antigen, claudin-1, and CD34 (Figure 3).