PMC10248242_01
Histologic features and immunohistochemical stains in this case of ALK+ LBCL. Histology demonstrated sheets of large monomorphic immunoblastic or plasmablastic cells with moderate to abundant amounts of lightly eosinophilic cytoplasm and abundant necrosis (A). The tumor cells were negative for CD3 (B), CD30 (C), and pancytokeratin (D); the tumor cells were positive for ALK (E), Oct2 (F), BOB1 (G), dim CD79a (H), CD45RB (I), IgG (J), TP53 (K), and c-MYC (L).
fonc-13-1174606-g001.jpg
PMC10248242_01_fonc-13-1174606-g001.jpg
f1
H&E stained slides of the nasopharyngeal mass showed sheets of large cells with round to oval nuclei, dispersed chromatin and prominent, often single, centrally located nucleoli ( Figure 1A ). A broad panel of immunostains was performed and the neoplastic cells were positive for ALK, Oct2, c-MYC, BOB1, CD45RB (LCA), CD79a (dim), CD10 (dim), Bcl-6 (subset), CD138, MUM-1, IgG. ( Figures 1B-L ).