PMC4933033_01
(A) Individual tumor cells established as primary culture. (B) Dose-response curve of the tumor cells established as primary culture and treated with Sorafenib for up to 144 h. Concentrations as indicated. Data reported present the mean +- SD of experiment performed in triplicates. Control: DMSO treated cells. (C) Dose-response curve of the tumor cells established as primary culture and treated with Sorafenib, Vandetanib and MLN8054 for 72 h. Concentrations as indicated. Data reported present the mean +- SD of experiment performed in triplicates. Control: DMSO treated cells.
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From fresh tumor tissue a primary cell culture was established and in vitro analysis of three different drugs demonstrated Sorafenib as the most effective one (Fig. 1A-C).
FDG-PET-CT screen of a pulmonary metastasis of ATC nine months after diagnosis.
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Imaging detected a new solitary lesion of 10 x 7 mm size in the right upper lobe of the lung that was suspicious for a metastasis (Fig. 2).