PMC8572618_01
(a, b) The subserosal tissue exhibits a prominent population of signet ring-like cells, associated with oedema and a delicate capillary network. (c) The signet ring-like cells show strong nuclear and cytoplasmic positivity for S100 protein. A small nerve (upper right) is also reactive for S100 staining.
CRIPA2021-4676885.001.jpg
PMC8572618_01_CRIPA2021-4676885.001.jpg
fig1
Within the subserosa, there was a prominent population of cells with signet ring morphology, characterised by a large single intracytoplasmic vacuole displacing the nucleus to the cell periphery (Figures 1(a) and 1(b)). They showed strong nuclear and cytoplasmic staining for S100 protein (Figure 1(c)).