PMC5727344_01
Gross photograph of mastectomy specimen with cut surface revealing a fibrous, grey-white, partially encapsulated tumor
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F1
Grossly, cut surface revealed a fibrous, grey-white, partly encapsulated 3.5x3 cm tumor with mucoid and glistening areas (Figure 1 (Fig. 1)).
Photomicrograph showing IDC with marked nuclear pleomorphism and atypical mitotic figures (H&E 400X)
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F2
Microscopically, the tumor had two distinct patterns; high grade IDC (Figure 2 (Fig. 2)) and tumor cells scattered singly, in groups and cords within a chondromyxoid matrix.
Photomicrograph showing tumor cells scattered singly, in groups and cords within a chondromyxoid matrix with atypical nuclei and eosinophilic cytoplasm (H&E 200X)
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F3
Mucoid to overtly cartilaginous areas were identified in the matrix (Figure 3 (Fig. 3)).
Photomicrograph showing invasive ductal carcinoma with an abrupt transition to chondromyxoid matrix without an intervening spindle cell component (H&E 200X)
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F4
The chondromyxoid matrix was multifocal, of high grade with abrupt transition between IDC component and metaplastic areas (Figure 4 (Fig. 4)).
Immunohistochemical profiling: Matrix-producing tumor cells showing positive immunoexpression for S100 and negative for cytokeratin (IHC 200X)
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F5
IDC cells stained positive for cytokeratin and negative for S100 (Figure 5 (Fig. 5)).
Immunohistochemical profiling: Infiltrating ductal carcinoma cells showing positive immunoexpression for cytokeratin and negative for S100 (IHC 200X)
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F6
MPC areas revealed immunoexpression for S100 and were negative for cytokeratin (Figure 6 (Fig. 6)).