PMC6389794_01
Chest X-ray showing a well-marginated, supra-diaphragmatic round opacity at the left lower zone. Computed tomography (CT) of his chest further revealed a large, 8 cm x 8 cm x 10 cm, supradiaphragmatic, complex solid mass in the lower left hemithorax, along the anterior chest wall, with incidental cystic lesion of liver (Fig. 2A).
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(A) Initial CT with arrow indicating a supradiaphragmatic, complex solid mass (Yellow arrow) with incidental cystic lesion of liver (Blue Arrow). (B) CT performed three months after surgery, showing resolution of the tumor. (C) CT at seven months post-surgery, with arrows demonstrating new pleural lesions and a mediastinal mass.
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A chest CT performed 3-months later showed no residual tumor or metastasis (Fig. 2B). CT showed a large left pleural-based mass, causing compression of surrounding structures, and a new right middle lobe lung lesion (Fig. 2C). CT guided biopsy of new lesion was done and was consistent with dedifferentiated LPS.
(A) Histopathology of dedifferentiated liposarcoma (LPS), showing numerous lipoblasts (hematoxylin and eosin [H&E] staining, magnification x 100). (B) Dedifferentiated LPS showing large pleomorphic cells arranged in a storiform pattern (H&E staining, magnification x 400).
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Gross pathology specimen of the excised tumor, showing sarcomatoid and lipomatous tissue.
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The biopsy confirmed dedifferentiated LPS and gross pathology of the excised tumor revealed sarcomatoid and lipomatous tissue (Fig. 4).