PMC6398342_01
Clinical presentation of cutaneous Candida
albicans infection. (a) Clinical appearance of the infection
showing multiple, hard papules on a scaly, reddish skin. (b) Improvement of
the papules after 2 weeks of oral fluconazole treatment.
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A 37-year-old man referred to our clinic for itchy, painless papules on his left foot (Figure 1(a)). No specific distribution pattern was noticed (Figure 1(a)). Therefore, the patient received oral fluconazole therapy (100 mg/die) and 2 weeks after treatment showed a clinical improvement characterized by a significant decrease in the number of papules (Figure 1(b)).
Peptide mass fingerprinting of Candida albicans
performed by MALDI-TOF MS.
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MALDI-TOF MS is shown in Figure 2. Microscopic examination of methylene blue-stained C. albicans culture highlighted the formation of true hyphae (Figure 3).
Filamentous stage of development of Candida
albicans. Formation of true hyphae in liquid Sabouraud medium
of the C. albicans isolated after 72 h at
28 C. The heat-fixed smear was stained with methylene blue. Images were
acquired with a magnification of 400x and relative insets at 1000x, using a
Leica DM5000B microscope equipped with Digital FireWire Color Camera systems
Leica DFX300 and processed using the Leica Application Suite 2.7.0.R1
software (Leica).
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MALDI-TOF MS is shown in Figure 2. Microscopic examination of methylene blue-stained C. albicans culture highlighted the formation of true hyphae (Figure 3).