PMC4274913_01
Hypochromic skin lesions associated with vitiligo.
CRII2014-394754.002.jpg
PMC4274913_01_CRII2014-394754.002.jpg
fig2
Earliest manifestations of vitiligo were observed at 12 years of age, with symmetrical patches of hypopigmented skin in ankles, knees, and hands (Figure 2).
Allergic reaction to Detemir. Note distribution of wheals and flares, as well as angioedema of lips and eyelids.
CRII2014-394754.003.jpg
PMC4274913_01_CRII2014-394754.003.jpg
fig3
One week after discharge, the patient attends emergency services again due to pruriginous papules in the neck, thorax, and limbs that appeared approximately 45 minutes after the Detemir injections (Figure 3), and one event during dinner-time injection associated with intense pruritus with glulisine dosage.