PMC3424652_01
Gross examination reveal pink-tan tissue fragments.
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fig1
Gross examination revealed two portions of pink-tan tissue measuring 7.3 x 2.8 x 1.4 cm and 4.5 x 2.8 x 1.2 cm (Figure 1).
Area of well-differentiated fatty component (arrow). The lesion is submucosal.
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Microscopic examination revealed a biphasic submucosal neoplasm (Figure 2) composed of a well-differentiated lipomatous component adjacent to a high-grade spindle cell sarcoma.
Examination of the fibrous septa shows atypical hyperchromatic stromal cells (arrow) and scattered lipoblasts (arrowhead).
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fig3
Examination of the well-differentiated areas showed mature adipose tissue with fibrous septae containing atypical hyperchromatic stromal cells and scattered lipoblasts (Figure 3) which involved the surgical resection margin.
The high-grade component was composed of atypical spindle cells with nuclear hyperchromasia.
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The morphologically high-grade component corresponded to the firm area identified grossly and was composed of atypical spindle cells with nuclear hyperchromasia and easily identifiable mitotic figures (Figure 4).
Fluorescence in situ hybridization studies showed amplification of the CPM gene.
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Fluorescence in situ hybridization studies showed amplification of the CPM gene (Figure 5).