PMC7246417_01
(a) Representative low-power image showing sheets of malignant cells and hemorrhage present between areas of extensive amyloid deposition (x40). (b) The amyloid deposits are Congo-Red positive (x100).
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Sections submitted from the mass demonstrated extensive deposition of amorphous, pale eosinophilic material involving the lamina propria, muscularis mucosa, submucosa, muscularis propria, and subserosa with prominent involvement of vessels (Figure 1(a)). Congo red stain (Figure 1(b)) and showed apple-green birefringence under polarized light, characteristic of amyloid. Closely intermingled with and diffusely infiltrating the amyloid deposits, there were sheets of highly atypical, plump spindled cells with amphophilic cytoplasm, oval large nuclei, prominent nucleoli, and frequent mitotic figures (Figures 2(a) and 2(b)).
(a, b) Diffuse infiltration of amyloid deposits by high-grade angiosarcoma (x200). (c-e) The malignant cells are positive for CD31 (patchy) (c), ERG (d), and MYC (e) (x400).
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Congo red stain (Figure 1(b)) and showed apple-green birefringence under polarized light, characteristic of amyloid. Closely intermingled with and diffusely infiltrating the amyloid deposits, there were sheets of highly atypical, plump spindled cells with amphophilic cytoplasm, oval large nuclei, prominent nucleoli, and frequent mitotic figures (Figures 2(a) and 2(b)). SOX10, S100 protein, and KIT (Figures 3(a)-3(d)). Strong expression of MYC protein by immunohistochemistry was present (Figure 2(e)).
(a-d) The tumor cells are negative for keratin AE1/AE3 (a), SOX10 (b), S100 (c), and KIT (d) (x100).
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SOX10, S100 protein, and KIT (Figures 3(a)-3(d)). Strong expression of MYC protein by immunohistochemistry was present (Figure 2(e)).