PMC6293043_01
Typical aspect of Darier disease before treatment with large papular keratotic closets of the folds.
gr1.jpg
PMC6293043_01_gr1.jpg
fig1
The area affected was greater than 50% of body surface area (Fig 1).
PMC6293043_02
PMC6293043_03
Clinically complete remission after 4 months of alitretinoin combined with topical 5-FU.
gr2.jpg
PMC6293043_03_gr2.jpg
fig2
The patient achieved a clinically complete remission of DD in 4 months (Fig 2).