PMC7387958_01
Hemophagocytosis on bone marrow smear (100x magnification).
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The aspirate smear was positive for hemophagocytosis (Figure 1).
Encapsulated fungus in the cytoplasm of mononuclear cells on bone marrow smear (100x magnification).
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Additionally, it also showed some inclusions on the marrow that were highly suspicious for a fungal infection (Figure 2).
Budding fungus from intracellular to extracellular space on silver staining of mononuclear cells on bone marrow smear (100x magnification).
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Encapsulated organisms with narrow based budding positive on silver stain were confirmed which clinched the diagnosis of disseminated histoplasmosis (Figure 3).