PMC5438001_01
Glomerulus showing a cellular crescent with fibrinoid necrosis (Jones methenamine silver stain x 200).
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Figure1
Light microscopy revealed 4 corticomedullary cores with 28 glomeruli, 5 of which were obsolescent. 16 glomeruli demonstrated cellular crescents with marked fibrinoid necrosis (Figure 1).
Obsolescent glomerulus with adjacent multinucleated giant cell (H & E x 200).
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Figure2
Obliteration of Bowman's capsules and periglomerular giant cells were noted in a few glomeruli (Figure 2).
Bright linear IgG staining of the glomerular capillary loops on immunofluorescence.
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Figure3
Bright capillary loop staining was seen with antisera specific for IgG (2+; scale trace through 3+), C3 (1+), and kappa and lambda light chains (both 2+) (Figure 3).
Necrotizing arteritis with transmural inflammation in the lung instertitium (H & E x 200).
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Figure4
The CT-guided lung biopsy revealed multiple cores with necrotizing granulomatous inflammation and focal vasculitis with associated multinucleated giant cells (Figure 4, Figure 5).
Multinucleated giant cells in the lung (H & E x 400).
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Figure5
The CT-guided lung biopsy revealed multiple cores with necrotizing granulomatous inflammation and focal vasculitis with associated multinucleated giant cells (Figure 4, Figure 5).