PMC6203236_01
Computed tomography image of the patient's neck demonstrates a homogeneous increase in the size of the left submandibular gland (arrow). No lymphadenopathy was present.
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Computed tomography imaging of the mass revealed left submandibular gland enlargement and no cervical lymphadenopathy (Fig. 1).
Permanent histopathology specimen of submandibular gland lesion (A) shows large regular islands of carcinoid tumor cells in a so-called organoid pattern on the right, with residual submandibular acini and ducts on the left (Hematoxylin & eosin staining; original magnification x100). (B) On higher (x400) magnification, features characteristic of neuroendocrine tumor cells are apparent with hematoxylin & eosin staining showing cells with a characteristic coarsely granular "salt-and-pepper" chromatin. (C) Positive chromogranin immunostaining is consistent with neuroendocrine tumor cells.
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Immunohistochemistry was again positive for chromogranin and synaptophysin, consistent with the previous FNA and was (Fig. 2).