PMC3303756_01
Hematoxylin and eosin staining of HPV11-positive urethral condyloma acuminatum showing koilocytosis and parakeratosis.
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fig1
HE staining. Histology of the urethral lesions showed koilocytosis and parakeratosis supporting the diagnosis as condyloma acuminatum (Figure 1).
Hematoxylin and eosin staining of bladder squamous papilloma (HPV negative).
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fig2
Hematoxylin and eosin staining of bladder urothelial inverted papilloma (HPV negative).
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fig3
Detection of HPV sequences by the PapiPlex method. Upper panel: urethral condyloma showing HPV11 sequences (arrow), lower panel: a squamous papilloma with no HPV sequences.
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fig4
HPV-6, 11, 16, 18, 30, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 66 DNA sequences were assessed at one time with the PapiPlex method using those DNA samples as templates. HPV-11 DNA sequences were detected in DNA extracted from the urethral condyloma, while no HPV DNA sequences were positive in any of the genomic DNA samples extracted from the bladder tumors (Figure 4).