PMC9849900_01
Color ultrasound. This image showed a hypoechoic mass in the posterior wall of the bladder. CDFI: no blood flow signal in the mass [arrow].
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CDFI: no blood flow signal in the mass was noted ( Figure 1 ).
MRI. This image showed a space-occupying lesion with long T1 signal in the right anterior wall of the bladder [(A), arrow]; this image showed a space-occupying lesion with short T2 signal in the right anterior wall of the bladder [(C), arrow]; the enhancement scanning was even [(E), arrow]; diffusion was limited [(G), arrow]. This image showed a space-occupying lesion with long T1 signal in the posterior upper wall of the bladder [(B), arrow]; this image showed a space-occupying lesion with short T2 signal in the posterior upper wall of the bladder [(D), arrow]; the enhancement scanning was even [(F), arrow]; diffusion was limited [(H), arrow].
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Pelvic magnetic resonance imaging indicated bladder cancer ( Figures 2A-H ).
Cystoscope. This image showed a space-occupying lesion in the posterior upper wall of the bladder [(A), arrow]; this image showed a space-occupying lesion in the right anterior wall of the bladder [(B), arrow].
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During the operation, the right side and posterior bladder wall showed two nodular lesions with a size of approximately 20 mmx15 mm and 10 mmx10 mm, with a broad base and little bleeding upon resection, respectively ( Figures 3A, B ).
Pathology. Hematoxylin-eosin staining of a surgical specimen. demonstrated MALT lymphoma [(A, B)]; Immunohistochemical staining. demonstrated ki-67 expression (C). Immunohistochemical staining demonstrated. CD20 expression (D).
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Histopathological studies of the resected tumors revealed a large number of proliferating lymphocytes, mainly medium-sized lymphocytes, and some with an empty cytoplasm; lymphoid follicular hyperplasia with irregular enlargement of the marginal area was noted ( Figures 4A, B ). Immunohistochemical studies of the tumors showed that the lesion was positive for the expression of CD20, CD79a, BCL-2, Ki-67 and CD21 and negative for CD3, CD5, CD10, CD23, CD138, cyclin D1 and lambda ( Figures 4C,D ).