PMC9477220_01
Histochemistry and immunohistochemistry of tumor tissue of primary cancer and lymph node metastasis.. Slides from formalin fixed paraffin embedded tissue samples form primary tumor and supraclavicular metastasis were stained for Hematoxylin-eosin, p16 and PD-L1.
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F1
Immunohistochemistry found 2% of the tumor cells expressing PD-L1. (Figure 1).
Contrast enhanced computed tomography of the chest and abdomen at beginning, during and at the end of nivolumab treatment.. Representative lymph node metastases are shown before, during at end of treatment. Arrows show the metastatic sites before start of treatment.
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F2
Staging with contrast-enhanced computed tomography after three months in May 2018 showed regression of lymph node metastasis (Figure 2). Treatment was continued until February 2020 and stopped thereafter with ongoing complete response in March 2020 (Figure 2).