PMC6000719_01
Two distinct gallbladder masses, one in gallbladder neck (arrow) as squamous cell carcinoma, and the other in fundus (arrowhead) as adenocarcinoma.
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Gross examination of the gallbladder by pathologist revealed a white-colored mass, measuring 3 * 2 cm in gallbladder neck and another mass in fundus, as wall thickening measured 5 * 3 cm (Fig. 1).
(A) Well-differentiated squamous cell carcinoma in gallbladder neck (100*magnification), with (B) squamous cells and keratinous pearl (400*magnification), and (C) well-differentiated adenocarcinoma in fundus (40*magnification), with (D) gland formation (200*magnification).
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Microscopic findings disclosed squamous cell carcinoma in gallbladder neck and adenocarcinoma in the fundus (Fig. 2), without any transitional areas between these two distinct masses.
Immunohistochemical staining for CK5/6 shows strong positive reactivity with diffuse cytoplasmic staining and perinuclear enhancement.
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Immunohistochemical staining for cytokeratin5/6(CK5/6) showed diffuse cytoplasmic staining with perinuclear enhancement (Fig. 3).