PMC6503594_01
Endoscopic view showing erythematous rectal mucosa (red arrow) with areas of
normal-looking mucosa (green arrow).
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Approximately, 25 cm from the anal canal, the colonoscopy revealed diffuse rectal erythematous and superficial ulcerations with areas of normal-looking mucosa (Figure 1, arrows).
The histologic view showing focally ulcerated rectal mucosa recovered by
normal epithelium with regular crypts without architectural distorsion. The
lamina propria is widely occupied by numerous variable-sized optically empty
vacuoles resembling adipocytes. (Hematoxylin-eosin 100x).
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The lamina propria was widely occupied by numerous variable-sized optically empty vacuoles resembling adipocytes (Figure 2).
Focally, the vacuoles are fused and form large spaces with discrete amorphous
and eosinophilic content (black arrow). The empty vacuoles are intermingled
with inflammatory cells and seem to be lined by cells with oval to flattened
nuclei (red arrow) (Hematoxylin-eosin 400x).
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Focally, these vacuoles were fused and form large spaces with discrete amorphous and eosinophilic content (Figure 3, black arrow). The empty vacuoles were intermingled with inflammatory cells and seem to be lined by cells with oval to flattened nuclei (Figure 3, red arrow).
Immunohistochemical view showing weak and focal positive staining with CD31
(a) and S-100 (b) around the empty spaces, corresponding to reactive
inflammatory cells of the lamina propria. Note the strong CD31 positive
staining around vascular spaces in the muscularis mucosae (red arrows)
(Immunohistochemistry 50x and 100x, respectively).
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The immunohistochemical analysis showed weak and focal positive staining with CD31 (Figure 4(a)) and S-100 (Figure 4(b)) around the empty spaces (vacuoles), corresponding to reactive inflammatory cells of the lamina propria.