PMC5511828_01
(A) H&E stain with necrotic fibers (arrow, 200x magnification), (B) stain for non-specific esterase with macrophages engulfing the necrotic myofiber (arrow, 200x magnification), (C) succinate dehydrogenase/cytochrome-C-oxidase (SDH/COX) combination stain with increased blue fibers, which lack cytochrome-C-oxidase function (arrows, 200x magnification), (D) DPNH stain with a nectoric fiber, but intact myotubular structures in the other myofibers (200x magnification).
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F1
The necrotic fibers accounted for approximately 1% of the fibers in the biopsy without a lymphocytic or plasma cell inflammatory infiltrate in the muscle (Figure 1A). Macrophages within the myofibers were englufing the necrotic fibers (Figure 1B). There was a mild increase in the number of myofibers whose mitochondrial respiratory functions were impaired or lost (Figure 1C). In chronic myopathic processes, the finding of moth-eaten fibers can be identified (Figure 1D).