PMC3745288_01
Skin biopsy showing calcium deposition in small arterioles.
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This pattern is strongly suggestive of calciphylaxis (Figure 1).
Day 10: thigh bullae and ulcerated skin.
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The patient developed a right foot blister on day 7 and bilateral thigh blisters on day 10 (Figure 4) that were attributed initially to volume overload.
Day 14: necrotic and eschar lesion.
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The skin became mottled and the lesions worsened progressively over 3 days to become necrotic eschars (Figure 5).
Day 17: worsening necrotic lesion on extremities, flanks and lower abdomen.
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Similar lesions developed over the lower extremities, flanks, and lower abdomen (Figure 6).
Progressively worsening lesions on bilateral thigh.
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Diffuse skin necrotic eschar.
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The patient had eschar lesions on the right lower extremity (75 x 20 cm), the left lower extremity (75 x 20 cm), and an abdominal lesion (10 x 5 x 5 cm) (Figure 8).