PMC4666177_01
Normal karyotype. Karyogram before cell expansion (bone marrow cells). Karyotype: 46,XY
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PMC4666177_01_13039_2015_197_Fig1_HTML.jpg
Fig1
This patient showed a normal karyotype: 46,XY[20] (Fig. 1).
Karyotype with trisomies. Karyogram after cell expansion, from the first cultivation (mesenchymal stem cells at second passage). Karyotype: 43,XY, +2,+4,+5,-10,-11,-14,-15,-18,-22
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PMC4666177_01_13039_2015_197_Fig2_HTML.jpg
Fig2
In the first cultivation, the MSC at second passage (P2) showed a hyperdiploid clone (Fig. 2), with a composite karyotype: 43 ~ 52,XY,+X,+4,+5,+10[cp4]/46,XY[18], and non-clonal trisomies:+2,+12,+20.
Karyotype with translocation. Karyogram after cell expansion, from the second cultivation (mesenchymal stem cells at third passage). Karyotype: 46,XY, t(9;18)(p24;q11)
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PMC4666177_01_13039_2015_197_Fig3_HTML.jpg
Fig3
At P3, these cells showed a clonal translocation: 46,XY,t(9;18)(p24;q11)/46,XY[5] (Fig. 3).