PMC9713765_01
Initial diagnosis pathology specimen of the first patient. Magnification, x2. Neoplastic proliferation developed at the expense of the posterior part of the uterine cervix over a thickness of 4.5 mm.
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No vaginal or paracervical involvement and no lymphovascular space involvement (LVSI) were found on the surgical specimens (Figs. 1 and 2). Reread of the trachelectomy pathology specimens concluded a major GCC with a minor SCC component (Figs. 1 and 2), whereas the biopsy of the recurrent lesion showed only SCC.
Initial diagnosis pathology specimen of the first patient. Magnification, x400. Poorly differentiated carcinoma arranged in the form of large, more or less anastomosing masses. The tumor cells were large, with abundant, eosinophilic, finely granular cytoplasm and a large nucleus, usually clear with a prominent nucleolus. Under the microscope, numerous figures of mitosis and marked anisokaryosis were observed. The stroma was inflammatory and rich in polynuclear eosinophilic cells.
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No vaginal or paracervical involvement and no lymphovascular space involvement (LVSI) were found on the surgical specimens (Figs. 1 and 2). Reread of the trachelectomy pathology specimens concluded a major GCC with a minor SCC component (Figs. 1 and 2), whereas the biopsy of the recurrent lesion showed only SCC.
Recurrence pathology specimen of the first patient. Magnification, x200. Ectocervix with high-grade dysplastic epithelium infiltrated by squamous cell carcinoma. The presence of foci of squamous intraepithelial neoplasia of grade 3 was observed. Infiltrating squamous cell carcinoma was associated with it, indicating tumor masses surrounded by a fibrous-inflammatory stroma. Some of the clusters were located between large vessels. Presence of an aspect of keratinization. The tumor cells were large, with eosinophilic cytoplasm. Anisocytosis and anisokaryosis were important. Figures of mitosis were frequently observed.
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The biopsy of this lesion confirmed the recurrence of a non-keratinizing SCC (Fig. 3).
PMC9713765_02
Initial diagnosis pathology specimen of the second patient. Magnification, x2. The presence of a tumor proliferation developed at the expense of the posterior lip of the uterine cervix over a thickness of 17 mm was observed.
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Results of definite pathology confirmed 13 disease-free lymph nodes and a 21 mm slightly-differentiated adenosquamous carcinoma with a morphologic appearance of GCC without lymphovascular invasion and minimal lateral safety margins of 3 mm (Figs. 4 and 5).
Initial diagnosis pathology specimen of the second patient. Magnification, x400. Poorly differentiated infiltrating carcinoma arranged in small clumps and trabeculae with poorly defined contours and focally arranged in the form of glands. The cells were small, with marked atypia; they had an atypical nucleus, often clear and glassy with a prominent nucleolus. Figures of mitosis were frequently observed. The stroma was highly inflammatory and contained numerous eosinophilic polynuclear cells.
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Results of definite pathology confirmed 13 disease-free lymph nodes and a 21 mm slightly-differentiated adenosquamous carcinoma with a morphologic appearance of GCC without lymphovascular invasion and minimal lateral safety margins of 3 mm (Figs. 4 and 5).
Recurrence pathology specimen of the second patient. Magnification, x2. Fibrous adipose tissue infiltrated by a poorly differentiated carcinoma.
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The CT scan-guided biopsy of this adenopathy confirmed the recurrence of GCC, despite the normal Scc level (Figs. 6 and 7).
Recurrence pathology specimen of the second patient. Magnification, x400. The tumor was arranged in trabeculae, the tumor cells were of medium size, the nuclei were hyperchromatic and irregular, and the cytoplasm was eosinophilic.
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The CT scan-guided biopsy of this adenopathy confirmed the recurrence of GCC, despite the normal Scc level (Figs. 6 and 7).