PMC5848354_01
Magnetic resonance imaging scan, coronal section, T2 image, showing enlargement of all extraocular muscles in the left orbit
OJO-11-65-g001.jpg
PMC5848354_01_OJO-11-65-g001.jpg
F1
Magnetic resonance imaging of the orbits revealed the enlargement of all extraocular muscles on the left side [Figure 1].
Histopathology of the left medial rectus muscle revealing chronic lymphocytic leukemia. (a) H and E, x40 revealing an infiltrate with multiple lymphocytes. (b) Positive immunohistochemistry with CD20 (a B cell marker). (c) Positive immunohistochemistry with CD5 (a chronic lymphocytic leukemia marker). (d) Positive immunohistochemistry with Ki-67 (suggestive of low-grade lymphoma)
OJO-11-65-g002.jpg
PMC5848354_01_OJO-11-65-g002.jpg
F2
An incisional biopsy was performed from the left medial rectus muscle and subsequent histological examination revealed a lymphocytic infiltrate between the muscle fibers that was compatible with CLL (CD20 and CD5 positive) [Figure 2].