PMC4039184_01
FDOJ sample completely converted the marrow of the JB to fatty tissue.
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In parallel to histopathology, we performed a Luminex -based cytokine analysis (Luminex Corporation, Austin, TX, USA) on the FDOJ of the lower right retromolar area 48/49 (in US terminology area 32), which is structurally similar to what was shown in Figure 1.
Tumor cells in the retromolar area of FDOJ tissue (HE 400-fold).
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FDOJ sample found hallmarks of osteonecrotic metastases of an adenocarcinoma of the breast. Figure 3 demonstrates the remarkably close accumulation and direct proximity of the tumor cells (red arrows) and necrotic adipocytes (green arrows), which we consider as a source of immunological networking by the FDOJ.
Analysis of seven cytokines in excised FDOJ tissue (retromolar area of the right mandible) from a MaCa patient in comparison to a normal JB.
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Results of the cytokine assay are presented in Figure 4.