PMC3362992_01
Perianal plaques in various stages of eruption.
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fig1
The lesions began eight weeks prior to presentation, were multiple, scattered in the perianal area and upper thigh bilaterally, and three centimeters at the widest diameter (Figure 1).
Skin biopsy with hematoxylin/eosin at 400x power. Lymphocytic infiltrate of dermis with enlarged endothelial cells and occasional magenta-colored intranuclear inclusions.
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However, the superficial dermis demonstrated a distinct perivascular lymphocytic infiltrate, and the endothelial cells were markedly enlarged (Figure 2).
Skin biopsy with immunoperoxidase stain at 400x power. Cytomegalovirus positive cell featured in the center of view.
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fig3
Some endothelial cells contained magenta-colored nuclear inclusions consistent with cytomegalovirus (CMV) infection which was confirmed by a positive CMV immunostain (Figure 3).