PMC4655025_01
Initial gangrene of the lower limb at admission.
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These lesions had a necrotic appearance, without granulation tissue, and were covered by purulent exudates (Figure 2).
Seven days after EBS treatment and standard dressing.
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After 7 days of therapy, the wide ulcers of the lower limb started to present some granulation tissue with irregular edges and discrete fibrinous exudate (Figure 3).
After 2 weeks of EBS treatment and standard dressing.
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Following a two-week EBS treatment period, all wide ulcers of the lower limb had improved with remarkable reduction and marked granulation tissue was apparent on the wide ulcers (Figure 4).
Skin ulcers completely heal after 5 weeks.
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EBS treatment, the ulcers on the leg had completely healed (Figure 5) and the patient was able to walk using a walking aid. ESR and CRP consequently decreased to almost normal values.
PMC4655025_02
Foot diabetic ulcer at admission.
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A skin examination performed at the time of admission showed a foot ulcer of about 2.5 cm involving the fascia, and it was evaluated as grade II according to the Wagner grading system (Figure 6).
Wound epithelization after 10 days of EBS treatment.
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 Figure 7 shows changes in the diabetic ulcer, respectively, after 10 days of treatment.
Complete diabetic ulcer healing at discharge.
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