PMC9277201_01
Transvaginal ultrasound of right adnexa. RT: right; TRANS: transverse.
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fig1
The official ultrasound showed a normal left ovary, no intrauterine pregnancy, a possible right ovary, and complex fluid within the right adnexa with an echogenic structure measuring 1.16 x 1.20 x 1.1 cm with circumferential color Doppler flow imaging, consistent with the "ring of fire" sign (Figure 1).
(a) Low power image of a partial mole shows an admixture of normal-appearing and enlarged hydropic villi scalloped borders. (b) High power image shows nucleated red blood cells (arrow) ((a) original magnification x100; (b) original magnification x400, hematoxylin and eosin (H&E) stain).
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The pathology results showed histologic features consistent with partial hydatidiform mole (Figure 2).
Genetic profiles of a dispermic partial hydatidiform mole by multiplex PCR assay. Dispermic paternal alleles (with homozygous paternal alleles in duplicate quantity in D8S1179 locus) shown, in addition to the presence of one maternal allele. Normal biallelic profiles seen in the (b) maternal endometrium.
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fig3
Molecular studies for gestational disease profile subsequently showed chorionic villi tissue genetically identical to maternal tissue in one set alleles and different in two sets of paternal alleles consistent with a partial mole genotype (Figure 3).