PMC5078756_01
Left ovary: carcinosarcoma associated with the wall of a dermoid cyst with no demonstrable connection with internal cyst lining (hematoxylin and eosin, 40x).
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fig1
The cystic component was a dermoid cyst composed of benign squamous epithelial lining with foci of cartilage, without connection between the cyst lining and malignant components (Figure 1).
(a) Left ovary: carcinosarcoma consists of glands with complex papillary embedded in a solid sarcomatoid proliferation (hematoxylin and eosin, 100x). (b) Left ovary: the epithelial component displays strong reactivity indicating cytokeratin (AE1/AE3) (100x). (c) Left ovary: the sarcomatoid cell population illustrates focal staining for vimentin, while most of the epithelial component showed negative results (100x).
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fig2
The mesenchymal component was high-grade pleomorphic and spindle cell sarcoma of a nonspecified type (Figure 2(a)). The immunohistochemical studies gave positive reactions for cytokeratin (AE1/AE3) and cytokeratin 7 in the carcinomatous component (Figure 2(b)), whereas only a rare focal reaction was observed in the sarcomatous part. The sarcomatous component showed focal immunoreactions for vimentin, desmin, and actin, while the epithelial component was negative with these stains (Figure 2(c)).
(a) Left fallopian tube: the serous tubal intraepithelial carcinoma (STIC) is noted in the tubal mucosa of the left fallopian tube (hematoxylin and eosin, 200x). (b) Left fallopian tube: the serous tubal intraepithelial carcinoma (STIC) displays strong nuclear p53 expression, in contrast to the adjacent tubal epithelia (200x).
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fig3
The left tubal serous adenocarcinoma and adjacent STIC also showed a similar abnormal p53 expression (Figure 3).