PMC9850144_01
Breast mass at 10 o'clock position. (A) Hematoxylin-eosin (HE) stain at 100x magnification shows tumor cells in a hemorrhagic necrotic background. (B) HE stain at 400x magnification shows sheet-like formation of epithelial cells with pleomorphic hyperchromatic nuclei, multiple prominent nucleoli and abundant vacuolated cytoplasm. No syncytiotrophoblastic cells are seen. (C) Immunohistochemistry shows all cancer cells strongly express human chorionic gonadotropin (hCG).
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GATA 3, cytokeratin 7, and mammoglobin were expressed, and the tumor cells did not express hCG as demonstrated in  Figure 1 .
Breast mass at 6 o'clock position. (A) HE staining at 100x magnification shows tumor cells with sheets, tubular, cords or single cell formation infiltrating through desmoplastic stroma. (B) HE staining at 400x magnification shows moderately differentiated tumor cells with high nuclear: cytoplasmic ratio and pleomorphic hyperchromatic nuclei infiltrating through desmoplastic stroma. (C) hCG IHC shows that all the cancer cells are negative for beta-HCG.
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Immunohistochemical stains found the tumor cells did not express estrogen, progesterone, or HER2 receptors (triple negative) with a markedly elevated proliferative marker, Ki-67, at 70%, with expression of cytokeratin 7, GATA3, and importantly, hCG as demonstrated in  Figure 2 .