PMC8576382_01
Right carotid body of Case 1 - Haematoxylin-eosin (A) and immunohistochemitries for CD61 (B; arrows: fibrin/platelet microthrombosis), nucleocapsid (C), Spike (D), CD68 (E) and CD3 (F). Scale bars: 100 microm (A, B); 50 microm (C-F).
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f1
The right (Figure 1) and left (Supplementary Figure 2) CBs showed severe blood congestion of microvasculature, with some small CD61-positive platelet thrombi.
Right carotid body of Case 2 - Haematoxylin-eosin (A) and immunohistochemitries for CD61 (B), nucleocapsid (C; arrows: positive cells), Spike (D), CD68 (E) and CD3 (F). Scale bars: 100 microm (A); 50 microm (B-F). Inserts: high magnification of positive type I cells; Scale Bar: 15 microm.
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f2
The right (Figure 1) and left (Supplementary Figure 2) CBs showed severe blood congestion of microvasculature, with some small CD61-positive platelet thrombi. In this case (Figure 2), some small CD61-positive platelet thrombi were also found in the vessels of the CB, in the presence of moderate congestion.
Right carotid body of Case 3 - Haematoxylin-eosin (A) and immunohistochemitries for nucleocapsid (B,C; arrows: positive cells), Spike (D), CD68 (E) and CD3 (F). Scale bars: 100 microm (A); 50 microm (B-F). Inserts: high magnification of positive type I cells. Scale Bar: 15 microm.
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f3
Both right (Figure 3) and left (Supplementary Figure 3) CBs showed similar features, characterized by increased connective tissue in the absence of blood congestion or microthrombosis.
Right carotid body of Case 4 - Haematoxylin-eosin (A) and immunohistochemitries for nucleocapsid (B-C; arrows: positive cells), Spike (D; arrows: positive cells), CD68 (E) and CD3 (F). Scale bars: 100 microm (A); 50 microm (B-F). Inserts: high magnification of positive type I cells. Scale Bar: 15 microm.
fimmu-12-736529-g004.jpg
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f4
Also in this case both CBs (right, Figure 4; left, Supplementary Figure 4) exhibited similar features.