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PMC8577432_02
Macroscopic lesions: facial pustules (a) and front papules (b). Macroscopic facial lesions appear similar to Acne vulgaris lesions.
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Three weeks post ART, few facial comedones, papules and pustules appeared (Fig. 1).
Microscopic aspect of the facial pustule (a, b). Haematoxylin and eosin staining magnification. (a) Ruptured infundibular epidermal cyst, with severe acute and chronic inflammation, 5X. (b) Mixed inflammation, mostly composed by granulocyte cells, surrounding the epidermal cyst, 20X.
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The histological microscopic examination showed an epidermal infundibular cyst with peripheral ulcer, associated to an acute and chronic inflammatory infiltrates into the dermal layer (Fig. 2).
Immunohistochemistry of the facial pustule. (a) A large amount of T CD3 lymphocyte cells, 10X (b) with a majority of T helper CD4 phenotype, 10X (c) with respect to T cytotoxic CD8 phenotype, 10X.
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The immune-phenotype study, revealed a large amount of T lymphocytes cells (CD3) with a majority of CD4 phenotype with respect to CD8 phenotype (Fig. 3).