PMC9898712_01
PET-CT before treatment. The scan showed abnormal accumulation in the mediastinal mass.
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Fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT showed abnormal accumulation with an SUV max of 14.24 in the mediastinal mass, which ran from the left supraclavicular fossa to the superior mediastinum and left pericardium (Figure 1).
Pathological findings of lymph node biopsy. Atypical large cells resembling centroblasts or immunoblasts showed dense proliferation with Hodgkin/Reed Sternberg cells. These atypical lymphoid cells were positive for CD30, weakly positive for PAX5, partially positive for CD20 and CD15, and negative for EBER. Numerous histiocytes were positive for CD68 and CD163.
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Additional immunostains highlighted atypical large cells positive for CD30 and PD-L1, weakly positive for PAX5, partially positive for CD20 and CD15, and negative for EBER (Figure 2).