PMC3573450_01
A single, dome-shaped, swelling is seen at the left index figure without significant changes of the overlying skin. Tumor nodule measures 2.0 x 2.3 cm in size
IDOJ-4-33-g001.jpg
PMC3573450_01_IDOJ-4-33-g001.jpg
F1
Swelling measured 2.0 x 2.3 cm in size [Figure 1].
(a and b) Scanner and low-power view showing highly cellular smear composed of syncytial clusters and many scattered cells (H and E stain); (c and d) syncytial cluster showing round to polygonal cells with abundant, finely granular cytoplasm with an ill-defined border, eccentric round to oval nuclei, evenly distributed chromatin and occasional small conspicuous nucleoli. Many fragile cells with stripped nuclei are evident in the background of finely granular material (H and E, x40); (e and f) MGG stain highlights the dispersed as well as clusters of tumor cells in finely granular material (H and E, x40)
IDOJ-4-33-g002.jpg
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F2
Nuclear atypia, mitosis, and necrosis were not observed [Figure 2].
(a) A tumor composed of sheets of large, round to polygonal cells with ill-defined cytoplasmic borders (H and E, x 10); (b and c) the tumor cells have abundant granular eosinophilic cytoplasm, round to oval centrally or eccentrically located nuclei with occasional small nucleoli. Eosinophilic ovoid bodies are surrounded by a clear halo (arrow and circle) (H and E, x40). On immunohistochemistry, (d) the tumor cells show strong cytoplasmic positivity for the S-100 protein (H and E, x40); (e) the tumor cells show positivity for vimentin (H and E, x40); (f) the tumor cells are negative for CD68 (H and E, x40)
IDOJ-4-33-g003.jpg
PMC3573450_01_IDOJ-4-33-g003.jpg
F3
CD68 was negative in tumor cells [Figure 3].