PMC9276994_01
An ultrasound scan showing severe polyhydramnios with a single DVP of 13.9 cm at 30 weeks and 2 days.
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F1
At 30 weeks + 2 days, a follow-up ultrasound scan showed significant polyhydramnios with an AFI of 35 cm and a single DVP of 13.9 cm (Figure 1).
An ultrasound scan showing an AFI of 24.1 cm at 31 weeks 2 days.
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F2
One week later, the AFI decreased from 35 to 24.1 cm (Figure 2), while the DA diameter significantly decreased from 3.8 to 3.1 mm (corresponding to the 1st centile).
An ultrasound scan shows DA diameter at 31 weeks 6 days (3.57 mm, 6th centile).
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F3
Four days later, the AFI increased to 28 cm, while the DA diameter increased to 3.57 mm [corresponding to the 6th centile (Figure 3)].
An ultrasound scan showing findings at 34 weeks + 2 days (A): AFI of 45.9 cm. (B): Umbilical artery Doppler waveform with increased PI above the 99th centile.
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F4
AFI at 45.9 cm (Figure 4A). At that point, the umbilical artery pulsatility index (PI), which was previously normal, increased considerably to 1.38 (Reference range 0.60-1.28 at 34 weeks, i.e., above the 99th centile) (Figure 4B). A summary of the changes in AFI and DA diameter in response to indomethacin dose adjustments is shown in Figure 5.
A summary diagram to outline changes in AFI and DA diameter during the antenatal indomethacin therapy of the patient.
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F5
At that point, the umbilical artery pulsatility index (PI), which was previously normal, increased considerably to 1.38 (Reference range 0.60-1.28 at 34 weeks, i.e., above the 99th centile) (Figure 4B). A summary of the changes in AFI and DA diameter in response to indomethacin dose adjustments is shown in Figure 5.
PMC9276994_02