PMC6174197_01
(A) thyroid fine-needle aspiration smear(400x, Giemsa stain) showing a small dishesive group of large, atypical, epithelioid cells with well-defined cell borders, pleomorphic and vesicular, central nuclei and eosinophilic cytoplasms. (B,C) Histology slides (B, 100x; C, 200x; H&E stain) show the above cells organized in sheets and papillae with fibrin cores or lining irregular vascular. Areas of recent and remote hemorrhage with siderophages can be seen. The tumor cell delimiting the vascular spaces are dishesive and pluristratified. Some cells show small intracytoplasmic lumina. (D) the tumor cells display diffuse nuclear stain for the vascular transcription factor Erg-1 (200x, DAB stain).
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F1
A diagnosis of malignancy was given (Category 6 according to Bethesda 2010) with a suggestion for an anaplastic carcinoma (Figure 1A). The final histologic diagnosis was primary epithelioid angiosarcoma of the thyroid, grade 3 according to FFCCS (Figures 1B-D).