PMC3420475_01
(a) Leukocytoclastic vasculitis of thin walled, papillary dermal vessels characterized by mural fibrinoid necrosis and nuclear dust (arrow). A marked perivascular neutrophilic infiltrate and many extravasated red blood cells are present (hematoxylin and eosin stain; 100x). (b) Intraluminal monoclonal immunoglobulin casts in superficial papillary dermal vessels. Note swollen endothelial cells (arrow) (periodic acid-schiff stain, 400x).
CRIM.RHEUMATOLOGY2011-124940.001.jpg
PMC3420475_01_CRIM.RHEUMATOLOGY2011-124940.001.jpg
fig1
A skin punch biopsy revealed leukocytoclastic vasculitis with cryoglobulin deposits (Figure 1).