PMC9668457_01
Liver biopsy (a, b) and explanted liver (c, d) show marked hepatitis that demonstrates progression from the biopsy time point to the explant. Panel a (Hematoxylin and Eosin) shows marked hepatitis with swollen hepatocytes, compared to the explant (panel c, Hematoxylin and Eosin), where most of the swollen hepatocytes are no longer visible while active inflammation persists. In both samples, adenovirus immunohistochemistry was negative (panels b and d; inset shows positive control for adenovirus). (Original magnification, panels a-d: 100x).
CRIT2022-9426175.001.jpg
PMC9668457_01_CRIT2022-9426175.001.jpg
fig1
Liver biopsy was performed on day of admission (DOA) 2, showing severe diffuse hepatocellular swelling with moderate portal and lobular lymphocytic and neutrophilic infiltration/inflammation without fibrosis (Figure 1).