PMC4855794_01
Colonoscopic image of a Type 3 tumor of the sigmoid colon.
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On annual colonoscopy, a slightly elevated 2-cm lesion with small central ulcer was seen in the sigmoid colon (Fig. 1).
(a) Gross pathology of a resected Type 3 tumor of the sigmoid colon. Black line is the section b. (b) Microscopic image of the section with focal neuroendocrine features. (H&E, 1.25x) Focal neuroendocrine features was seen in the area of the black square (Fig. 3a-d).
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The histopathology of the specimen revealed a tubular adenocarcinoma invading to the muscularis propria (pMP) with focal neuroendocrine differentiation (Fig. 2a). Neuroendocrine features were found in the marginal area of the tumor, (Figs. 2 b, 3 a) which stained positive for both Chromogranin A (Fig. 3b) and Synaptophysin (Fig. 3c) and negative for CD56 (Fig. 3d), Ki67 index was 50%.
(a) Microscopic image showing focal neuroendocrine features (H&E, 4x). (b) Chromogranin stain in the area of focal neuroendocrine features (4x). (c) Synaptophisin stain in the area of focal neuroendocrine features (4x). (d) CD56 stain in the area of focal neuroendocrine features(4x).
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Neuroendocrine features were found in the marginal area of the tumor, (Figs. 2 b, 3 a) which stained positive for both Chromogranin A (Fig. 3b) and Synaptophysin (Fig. 3c) and negative for CD56 (Fig. 3d), Ki67 index was 50%.