PMC6186323_01
CT appearance of the three cases and pathological features of case 3. Panel (a) showed diffused reticulation as the manifestation of suspected GLILD in case 1. Panel (b) showed focal hypodense splenic lesions with splenomegaly in case 1. Panel (c) showed bronchiectasis with infiltrates and mucus plugs in case 2. Panel (d) showed diffused micronodules and bronchiectasis as the manifestation of GLILD in case 3. Panels (e) and (f) revealed diffused infiltration of lymphocytes and lymphoid follicles formation in the lung tissues, scattered with epithelioid granulomas and multinuclear giant cells, consistent with the pathological manifestation of GLILD.
BMRI2018-3724630.001.jpg
PMC6186323_03_BMRI2018-3724630.001.jpg
fig1
CD4+/CD8+ ratio were also detected (Table 1). Chest CT demonstrated diffused nodules, bronchiectasis, and mediastinal lymphadenopathy (Figure 1(d)), with a severe restrictive ventilatory defect and a diffusion impairment confirmed by PFTs. Wedge resection of the right middle lobe and right lower lobe was performed; the diagnosis of GLILD was confirmed by pathology subsequently (Figures 1(e) and 1(f)).
PMC6186323_02
CT appearance of the three cases and pathological features of case 3. Panel (a) showed diffused reticulation as the manifestation of suspected GLILD in case 1. Panel (b) showed focal hypodense splenic lesions with splenomegaly in case 1. Panel (c) showed bronchiectasis with infiltrates and mucus plugs in case 2. Panel (d) showed diffused micronodules and bronchiectasis as the manifestation of GLILD in case 3. Panels (e) and (f) revealed diffused infiltration of lymphocytes and lymphoid follicles formation in the lung tissues, scattered with epithelioid granulomas and multinuclear giant cells, consistent with the pathological manifestation of GLILD.
BMRI2018-3724630.001.jpg
PMC6186323_03_BMRI2018-3724630.001.jpg
fig1
CD4+/CD8+ ratio were also detected (Table 1). Chest CT demonstrated diffused nodules, bronchiectasis, and mediastinal lymphadenopathy (Figure 1(d)), with a severe restrictive ventilatory defect and a diffusion impairment confirmed by PFTs. Wedge resection of the right middle lobe and right lower lobe was performed; the diagnosis of GLILD was confirmed by pathology subsequently (Figures 1(e) and 1(f)).
PMC6186323_03
CT appearance of the three cases and pathological features of case 3. Panel (a) showed diffused reticulation as the manifestation of suspected GLILD in case 1. Panel (b) showed focal hypodense splenic lesions with splenomegaly in case 1. Panel (c) showed bronchiectasis with infiltrates and mucus plugs in case 2. Panel (d) showed diffused micronodules and bronchiectasis as the manifestation of GLILD in case 3. Panels (e) and (f) revealed diffused infiltration of lymphocytes and lymphoid follicles formation in the lung tissues, scattered with epithelioid granulomas and multinuclear giant cells, consistent with the pathological manifestation of GLILD.
BMRI2018-3724630.001.jpg
PMC6186323_03_BMRI2018-3724630.001.jpg
fig1
CD4+/CD8+ ratio were also detected (Table 1). Chest CT demonstrated diffused nodules, bronchiectasis, and mediastinal lymphadenopathy (Figure 1(d)), with a severe restrictive ventilatory defect and a diffusion impairment confirmed by PFTs. Wedge resection of the right middle lobe and right lower lobe was performed; the diagnosis of GLILD was confirmed by pathology subsequently (Figures 1(e) and 1(f)).