PMC4636166_01
Corneal graft melting.. Note: Corneal graft melting observed when patient came to the emergency ward.
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The patient also observed the appearance of a wide white spot in the center of the cornea from a few days (Figure 1).
Corneal graft perforation with iris prolapse.. Note: Corneal graft melting rapidly progressed to corneal perforation with iris prolapse although given the systemic and topic broad-spectrum antibiotic therapy.
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Corneal graft melting progressed to perforation with iris prolapse in 2 days (Figure 2).
Corneal ulcer before study treatment.. Note: Corneal ulcer affected epithelium, Bowman membrane, and anterior stroma with a longest linear diameter equal to 7 mm and a greatest perpendicular width equal to 5 mm.
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Corneal photography at a magnification of x16 showed that a large persistent epithelial defect with longest linear diameter equal to 7 mm, greatest perpendicular width equal to 5 mm, and smooth, rolled edges (Figure 3).
Confocal microscopy analysis of corneal ulcer before study treatment.. Note: Confocal microscopy analysis showed no nerve regeneration and stromal inflammation in corneal graft.
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Confocal microscopy analysis showed no nerve regeneration and stromal inflammation in the corneal graft (Figure 4).
Corneal ulcer after 2 weeks of study treatment (V2).. Note: Corneal ulcer improved after therapy with a partial healing >50% already in V2.
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In detail, corneal photographies showed partial healing >50% already in V2 (Figure 5) and a complete healing in V4 (Figure 6).
Corneal ulcer healing after 4 weeks of study treatment (V4).. Note: Corneal ulcer completely healed in V4.
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In detail, corneal photographies showed partial healing >50% already in V2 (Figure 5) and a complete healing in V4 (Figure 6).
Confocal microscopy analysis of the cornea after 4 weeks of study treatment (V4).. Note: Confocal miscroscopy showed complete resolution of stromal inflammation in V4.
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Confocal microscopy showed complete resolution of stromal inflammation in V4 (Figure 7).