PMC3521439_01
A - Atrophic lymphoid follicle, with expanded mantle zone with a concentric
appearance (H & E x 200). B - Plasma cells in interfollicular areas (H ;& E x 200). C - Immunohistochemistry showing plasmablasts positive for HHV8-LANA1
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The interfollicular areas also were expanded - containing a large quantity of mature plasma cells - and highly vascularized (Figures 1A and 1B). The immunohistochemical study with HHV-8-LANA-1 revealed plasmablasts with nuclear positivity within the mantle zones, as well as the positivity in scattered endothelial cells in the lymphoid follicles (Figure 1C).
A - Note the capsular thickening and ill-formed vascular channels (H & E x
100). B - Immunohistochemistry with anti-HHV8-LANA1 showing nuclear positivity in
spindle cells and in the endothelial cells lining the vascular channels
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Focal areas of capsular thickening in the routine H & E stain were also observed (Figure 2A).