PMC10294216_01
PET/CT of patient 1 showing FDG activity before and after MRONJ treatment with teriparatide (December 15, 2020 - February 9, 2021). a Prior to treatment, right upper molar region showed molar area activity with SUV 11.2 on October 16, 2019. b PET/CT showed no uptake on June 24, 2020. c PET/CT showed no uptake in the jaw on November 30, 2022.
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F1
Prior to MRONJ treatment (July 22, 2019), positron emission tomography-computed tomography (PET/CT) showed FDG activity in the right upper molar region (SUV 11.2) on 10/16/19 (shown in Fig. 1a), with a prior image of the area (SUV5.5). After beginning treatment, follow-up PET/CT on June 24, 2020, showed no uptake (shown in Fig. 1b). The last PET/CT on November 30, 2022, also did not show uptake in the jaw (shown in Fig. 1c).
PMC10294216_02
PET/CT of patient 2 showing FDG activity before and after MRONJ treatment with teriparatide (May 24, 2021 - July 19, 2021). a SPECT imaging with technetium-99 on November 24, 2020 showed the greatest uptake in the left maxilla and left mandible. b PET/CT on January 11, 2022 did not show uptake in the jaw.
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F2
On November 24, 2020, greatest uptake was seen in the left maxilla and left mandible (shown in Fig. 2a). CT face/neck with contrast, January 11, 2022, suggested bony sequestra in the left maxilla, with soft tissue thickening of the sinus floor (shown in Fig. 2b).
PMC10294216_03
PET/CT of patient 3 showing FDG activity before and after MRONJ treatment. a A panoramic image of the jaws on September 30, 2021 showed irregularity of bone in the right maxillary bone, with loss of visible sinus floor. b Panoramic imaging on August 3, 2022 showed loss of the bicuspid lower left, bone loss in the right upper jaw, the sinus floor appeared intact, and no visible sinus lining thickening.
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F3
A panoramic image of the jaws on September 30, 2021, showed irregularity of bone in the right maxillary bone, with loss of visible sinus floor (shown in Fig. 3a). Panoramic imaging on August 3, 2022, showed loss of bicuspid lower left, bone loss in the right upper jaw, sinus floor appeared intact, and no visible sinus lining thickening (shown in Fig. 3b).