PMC6617654_01
a Photograph of the patient at age 4 (left) compared to 26 (right). b Coronal view of brain MRI with no abnormality detected c Growth charts constructed with standard data obtained from CDC. Stature (top), and weight (middle) display a drop in linear growth and significant weight gain at 4 years of age; increased linear growth upon initiation of growth hormone at age 7 with a plateau following discontinuation at age 14. BMI (bottom) has been in the obese range since age 4. d 10-day glucose tracing by insulin pump shows improvement in blood glucose after 8-12 h of starting GLP-1 agonist, liraglutide, on May 16
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Fig1
Her insulin requirements dropped precipitously to less than 30% of baseline doses within 8 to 12 h of initiation (Fig. 1d).
PMC6617654_02
a Photograph of the patient at age 4 (left) compared to 26 (right). b Coronal view of brain MRI with no abnormality detected c Growth charts constructed with standard data obtained from CDC. Stature (top), and weight (middle) display a drop in linear growth and significant weight gain at 4 years of age; increased linear growth upon initiation of growth hormone at age 7 with a plateau following discontinuation at age 14. BMI (bottom) has been in the obese range since age 4. d 10-day glucose tracing by insulin pump shows improvement in blood glucose after 8-12 h of starting GLP-1 agonist, liraglutide, on May 16
40842_2019_82_Fig1_HTML.jpg
PMC6617654_02_40842_2019_82_Fig1_HTML.jpg
Fig1
Her insulin requirements dropped precipitously to less than 30% of baseline doses within 8 to 12 h of initiation (Fig. 1d).
a MRI abdomen showing hepatocellular carcinoma in the left lobe (BCLC stage A). b The liver mass biopsy showed a small amount of fibrotic background liver. The main lesion was a well-differentiated hepatocellular neoplasm composed of sheets of lesional hepatocytes and absence of normal portal structures. c This higher magnification of the hepatocellular neoplasm shows an unpaired artery (*) and surrounding well-differentiated neoplastic hepatocytes. d Trichrome stain highlights cirrhotic background
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Fig2
The biopsy of the lesion favored the diagnosis of a well differentiated hepatocellular carcinoma (Fig. 2).