PMC6580185_01
Liver function test values before, during, and after treatment with voriconazole. Day 1 refers to the first day of the first induction chemotherapy.
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Ten days after starting voriconazole, however, her liver transaminases rose, accompanied by only slightly elevated cholestatic parameters and normal bilirubin levels ( Figure 1 ).
Liver function test values before, during, and after treatment with posaconazole. Day 1 refers to the first day of the second induction chemotherapy. Isavuconazole treatment was started on day 29.
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After 4 days of posaconazole treatment, liver enzymes began to rise ( Figure 2 ). However, despite this, transaminases continued to rise ( Figure 2 ).
Isavuconazole treatment, chemotherapy, and allogenic HSCT (day 46). Day 1 refers to the first day of isavuconazole treatment.
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During the first weeks of treatment with isavuconazole, transaminases steadily decreased, and the patient improved clinically ( Figure 3 ).