PMC4325382_01
Fine-needle aspiration smears show increased cellularity with mostly single, dispersed cells and occasional larger clusters of plasmacytoid cells. The nuclei are relatively monomorphic, eccentrically placed and have fine nuclear chromatin. (a, b) Pap smear. (c) Diff-Quik
CJ-12-1-g001.jpg
PMC4325382_01_CJ-12-1-g001.jpg
F1
The overall cytomorphological findings were consistent with a well- to moderately-differentiated mammary carcinoma with plasmacytoid features, raising concern for a neuroendocrine carcinoma [Figure 1].
Invasive carcinoma comprised of plasmacytoid tumor cells, is seen on hematoxylin and eosin-stained tissue sections of the core needle biopsy (a). The tumor cells are immunopositive for synaptophysin which supports the diagnosis of neuroendocrine carcinoma (b)
CJ-12-1-g002.jpg
PMC4325382_01_CJ-12-1-g002.jpg
F2
Due to the lack of cell block material from the FNAB, a CNB was subsequently performed under US guidance [Figure 2].