PMC3426187_01
Section of intestine showing diffuse infiltration of mucosa and submucosa by neoplastic monotonous medium-sized cells. Individual cells have pale nuclei and occasional prominent nucleoli (Inset) ( H&E x 100X, Inset: H&E x 400X).
CRIM.GM2012-425358.001.jpg
PMC3426187_01_CRIM.GM2012-425358.001.jpg
fig1
Histology from the thickened ileum showed similar neoplastic monotonous cells of suspected lymphoid morphology as observed in the stomach (Figure 1).
Section of intestine showing neoplastic cells strongly positive for CD34 (immunohistochemistry x 400X).
CRIM.GM2012-425358.002.jpg
PMC3426187_01_CRIM.GM2012-425358.002.jpg
fig2
Immunohistochemistry performed on both stomach and ileum showed diffuse and strong positivity for CD34, MPO Ckit, MiB1 being 70% and negativity for CD3, CD20, and CD10 (Figures 2 and 3), thus making a diagnosis of extramedullary myeloid tumour or involvement by AML.
Section of intestine showing neoplastic cells strongly positive for MPO (immunohistochemistry x 400X).
CRIM.GM2012-425358.003.jpg
PMC3426187_01_CRIM.GM2012-425358.003.jpg
fig3
Immunohistochemistry performed on both stomach and ileum showed diffuse and strong positivity for CD34, MPO Ckit, MiB1 being 70% and negativity for CD3, CD20, and CD10 (Figures 2 and 3), thus making a diagnosis of extramedullary myeloid tumour or involvement by AML.
Bone marrow aspirate showing hypercellular marrow with 90% blasts morphology cells (Wrights x 1000X).
CRIM.GM2012-425358.004.jpg
PMC3426187_01_CRIM.GM2012-425358.004.jpg
fig4
Subsequently, a bone marrow aspirate and biopsy done showed a hypercellular marrow containing almost 85%-90% cells of blast morphology, thus confirming marrow involvement by acute leukemia (Figure 4).