PMC8712336_01
Baseline MRI of the uterine cervix SCCOHT. The cervical tumor grows atypically more around the uterus, than infiltrating it. Expansive tumor growth with pressing to the bladder or rectum, with no clear infiltration into adjacent organs.
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F1
Magnetic resonance imaging (MRI) of the pelvis revealed a tumor measuring 80 x 90 x 80 mm, growing from the cervical region, de facto resembling the uterus (Figure 1), filling the vagina, pressing on the bladder and rectum, without clear invasion into adjacent organs.
MRI confirming a partial tumor response 1 month after completion of radiotherapy at a dose of 59.4 Gy in 33 fractions. The treatment response was obvious, however incomplete.
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F2
The partial regression of both the tumor and lymphadenopathy was confirmed by MRI (Figure 2).
CT scan confirming rapid tumor dissemination with omental, liver, lung, and pleural metastases, with ascites and bilateral pleural effusion.
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F3
Although partial regression of the pelvic tumor was confirmed on the whole-body CT scan, there was massive systemic progression of the disease with mediastinal and neck lymphadenopathy, multiple metastatic lesions of the lungs and pleura with bilateral pleural effusions, multiple liver metastases (largest 52 x 36 mm), omental involvement with soft tissue masses (largest 72 x 56 mm), and ascites (Figure 3).
SMARCA4-deficient carcinoma of uterine cervix resembling SCCOHT. The tumor consists of cells with enlarged vesicular nuclei with clearly visible nucleoli and abundant eosinophilic cytoplasm. It is so-called large cell, or rhabdoid, variant of this tumor (hematoxylin-eosin, original magnification 400x).
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F4
Microscopically, the tumor was composed entirely of large cells with vesicular, less commonly hyperchromatic nuclei, frequently with prominent nucleoli, and with abundant eosinophilic cytoplasm, sometimes imparting a rhabdoid appearance (Figure 4).
SMARCA4-deficient carcinoma of uterine cervix resembling SCCOHT. Tumor cells are negative for SMARCA4 expression. The brown staining of the nuclei of non-tumor fibroblasts and inflammatory cells can serve as a positive internal control. (immunohistochemistry, original magnification 400x).
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F5
BRG-1) expression (Figure 5).