PMC10092711_01
Inframammary (A), axillary (B), and neck (C) Hailey-Hailey disease skin lesions.
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Disease Activity Score-28 (DAS28-CRP) for RA with C-reactive protein. During physical examination, multiple skin lesions with exudative intertriginous papulovesicles and erythematous plaques with erosions and painful fissures were observed, affecting axillae, inframammary folds, and neck (Figure 1).
Inframammary (A), axillary (B), and neck skin (C) after methotrexate therapeutic regimen.
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In subsequent consultations, following a progressive tapering of prednisolone dosage and increase in weekly methotrexate to a maximum of 20 mg/week, the patient presented RA remission with a DAS28-CRP score of 1.70 and progressive amelioration of skin lesions, giving place to hyperpigmented lichenified plaques, with improvement of erosions and fissures, and absence of exudation (Figure 2).