PMC8437414_01
Physical examination of the female patient diagnosed as mediastinal small cell carcinoma complicated with primary cutaneous cryptococcosis. Multiple painful skin lesions with erythema and swelling on both thighs (A and B). Abscesses on both thighs (C and D).
IDR-14-3693-g0001.jpg
PMC8437414_01_IDR-14-3693-g0001.jpg
f0001
Physical examination indicated painful skin lesions with erythema, swelling and abscesses on both thighs (Figure 1A-D).
Computed tomography (CT) scan of the chest and abdomen. Multiple metastases of the tumor were observed in the lung (A), liver, vertebral body (B), retroperitoneum (C), and caput femoris (D).
IDR-14-3693-g0002.jpg
PMC8437414_01_IDR-14-3693-g0002.jpg
f0002
Laboratory assay results revealed that carbohydrate antigen 125 (CA125), CA199 and neuron-specific enolase (NSE) were substantially increased, while results of her computed tomography (CT) scan of the chest and abdomen showed multiple metastases of the tumor within the lung, liver, left adrenal gland, retroperitoneum, vertebral body and caput femoris (Figure 2A-D).
Treatment with cutting the abscesses and lavaging the abscess cavities with fluconazole saline solution (A). A large amount of pus from the abscesses (B). Inflammation within the skin lesions was obviously improved after a week of treatment (C and D).
IDR-14-3693-g0003.jpg
PMC8437414_01_IDR-14-3693-g0003.jpg
f0003
Treatment with fluconazole (400 mg/day) via intravenous infusion was then initiated and the abscess cavities were rinsed with fluconazole saline solution twice daily after local incision and drainage (Figure 3A and B). After a week of this treatment, inflammation within the skin lesions was clearly improved (Figure 3C and D), but wound healing was very slow due to the cachexia resulting from the advanced stage of the tumor.