PMC4068904_01
General design of OGSF representing genetic susceptibility to vaccine adverse event. Square boxes denote classes, and italicized terms along the arrows denote relations.
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F2
Figure 3 by following the general OGSF design pattern (Figure 2). For ontological modeling, it is critical to generate description logic constraints and axioms to accurately represent human- and computer-interpretable knowledge.
OGSF modeling of vaccine-associated multiple sclerosis. Square boxes denote classes, and curved box denote instances.
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F3
Figure 3 by following the general OGSF design pattern (Figure 2). For ontological modeling, it is critical to generate description logic constraints and axioms to accurately represent human- and computer-interpretable knowledge. Case Study 1 is such a study, which is represented as 'genetic association study_1' (Figure 3). This figure does not include many linkages and axioms similar to those illustrated in Figure 3.
OGSF modeling of case study 2. Square boxes denote classes, and curved boxes denote instances.
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F4
The OGSF design pattern was applied to represent the information from these clinical trial studies (Figure 4). Instead, Figure 4 focuses on representation of statistics providing evidence indicating the type of genetic associations to vaccine adverse events.