PMC2905698_01
Panel (a) shows an area of invasive, keratinizing squamous cell carcinoma that has infiltrated beyond the muscularis propria (detrusor muscle) and into the perivesical adipose tissue. There is an associated desmoplastic reaction to the tumor. Panel (b) demonstrates the extensive squamous metaplasia seen in the background benign urothelium. Adjacent to the invasive tumor were foci of squamous cell carcinoma in situ (Panel (c)). Original magnification:200x (panel (a)), 400x (panels (b), and (c)).
AU2010-179250.002.jpg
PMC2905698_01_AU2010-179250.002.jpg
fig2
The adjacent bladder mucosa showed focal squamous cell carcinoma in situ and extensive squamous metaplasia of the surrounding benign urothelium (Figure 2).