PMC5306993_01
Transurethral bladder resection specimen displaying plasmacytoid tumor cells, with eccentric nuclei and eosinophilic cytoplasm. There is occasional intracytoplasmic vacuolization (H&E, x400).
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fig1
On H&E staining, the basic morphology of the tumor cells was plasmacytoid, with eccentric nuclei and eosinophilic cytoplasm (Figure 1).
Strong and diffuse nuclear immunoreactivity for GATA3 by tumor cells in the transurethral bladder resection specimen (x400).
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fig2
Tumor cells displayed both strong and diffuse nuclear reactivity for p53 and GATA3 (Figure 2).
Duodenal biopsy with atypical cells in submucosal location, showing enlarged nuclei and nucleoli, with partial plasmacytoid morphology. These cells were presented in a single cell pattern (H&E, x400).
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fig3
Some sparse interspersed atypical cells were noted in this layer, showing enlarged nuclei and nucleoli, with partial plasmacytoid morphology (Figure 3).
Duodenal biopsy showing strong nuclear GATA3 immunoreactivity in many tumor cells, which are observed more readily on immunostaining than on H&E histology (x100).
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fig4
They were immunoreactive for OSCAR pankeratin and GATA3 and, thus, were considered consistent with the previously diagnosed PUC (Figure 4).