PMC8591027_01
Evaluation of lesioned site and tactile threshold. (A)
Left panel: the computed tomography (CT) images of patient 1 at onset and 4 weeks post-onset show a high-and low-density area in the left thalamus, respectively. Right panel: the CT image at onset and T1-weighted magnetic resonance image at 5 weeks post-onset in patient 2 show a high-density area and a low signal-intensity area in the right thalamus, respectively. (B) Left panel showing tactile thresholds in patient 1. Right panel showing tactile thresholds in patient 2. The monofilaments of 20 different sizes (1.65-2.83, 3.22-3.61, 3.84-4.31, 4.54-6.45, and 6.65 expressed as the log of the bending force in mg) were applied to the index finger (three points), mother finger (one point), middle finger (three points), and palm (five points). Normal: 1.65-2.83; diminished light touch: 3.22-3.61; diminished protective sensation: 3.84-4.31; loss of protective sensation: 4.56-6.45; deep pressure sensation: 6.65; and unmeasurable: >6.65.
fnhum-15-761186-g001.jpg
PMC8591027_02_fnhum-15-761186-g001.jpg
F1
Head CT showed a high-density area in the right thalamus (Figure 1A). Briefly, monofilaments of 20 different sizes (1.65-2.83, 3.22-3.61, 3.84-4.31, 4.54-6.45, and 6.65 expressed as the log of the bending force in mg) were applied to the index finger (three points), mother finger (one point), middle finger (three points), and palm (five points) (Figure 1B).
PMC8591027_02
Evaluation of lesioned site and tactile threshold. (A)
Left panel: the computed tomography (CT) images of patient 1 at onset and 4 weeks post-onset show a high-and low-density area in the left thalamus, respectively. Right panel: the CT image at onset and T1-weighted magnetic resonance image at 5 weeks post-onset in patient 2 show a high-density area and a low signal-intensity area in the right thalamus, respectively. (B) Left panel showing tactile thresholds in patient 1. Right panel showing tactile thresholds in patient 2. The monofilaments of 20 different sizes (1.65-2.83, 3.22-3.61, 3.84-4.31, 4.54-6.45, and 6.65 expressed as the log of the bending force in mg) were applied to the index finger (three points), mother finger (one point), middle finger (three points), and palm (five points). Normal: 1.65-2.83; diminished light touch: 3.22-3.61; diminished protective sensation: 3.84-4.31; loss of protective sensation: 4.56-6.45; deep pressure sensation: 6.65; and unmeasurable: >6.65.
fnhum-15-761186-g001.jpg
PMC8591027_02_fnhum-15-761186-g001.jpg
F1
Head CT showed a high-density area in the right thalamus (Figure 1A). Briefly, monofilaments of 20 different sizes (1.65-2.83, 3.22-3.61, 3.84-4.31, 4.54-6.45, and 6.65 expressed as the log of the bending force in mg) were applied to the index finger (three points), mother finger (one point), middle finger (three points), and palm (five points) (Figure 1B).
Paired median nerve somatosensory evoked potential in patient 1. Left panels: to investigate the effect of the conditioning stimulus (CS) on the SEP induced by the test stimulus (TS), the single median nerve SEPs (single SEP) (right-MN: CS alone), and the paired median nerve SEPs (p-SEP) were recorded at the CP3 and CP4 electrodes. In the p-SEP recording, the right-MN stimulus (CS) was performed 1 ms after the left-MN stimulus (TS). Right panels: all SEP waveforms at CP3 and CP4 from patient 1. We compared the SEP averaged over the first 250 epochs with the SEP averaged over the second 250 epochs (total number of epochs recorded: 500). Black line: the SEP averaged over the first 250 epochs. Red line: the SEP averaged over the second 250 epochs. Gray line: the SEP averaged over all epochs (500 epochs) (TS alone condition). Green line: the SEP averaged over all epochs (500 epochs) [(TS + CS) - CS alone condition]. Dotted line: the time duration of stimulation. MN, median nerve.
fnhum-15-761186-g002.jpg
PMC8591027_02_fnhum-15-761186-g002.jpg
F2
In the s-SEP paradigm, s-SEPs were obtained by stimulation of the right and left median nerves at the wrist (Figures 2, 3). We calculated and compared the average of the SEP from 1 to 250 epochs with those from 251 to 500 epochs (Figures 2, 3).
Paired median nerve somatosensory evoked potential in patient 2. Left panels: to investigate the effect of conditioning stimulus (CS) on the SEP induced by the test stimulus (TS), the single median nerve SEPs (single SEP) (left-MN: CS alone), and the paired median nerve SEPs (p-SEP) were recorded at the CP3 and CP4 electrodes. In the p-SEP recording, the left-MN stimulus (CS) was performed 1 ms after the right-MN stimulus (TS). Right panels: all SEP waveforms at CP3 and CP4 from patient 2. We compared the SEP averaged over the first 250 epochs with the SEP averaged over the second 250 epochs (total number of epochs recorded: 500). Black line: the SEP averaged over the first 250 epochs. Red line: the SEP averaged over the second 250 epochs. Gray line: the SEP averaged over all epochs (500 epochs) (TS alone condition). Green line: the SEP averaged over all epochs (500 epochs) [(TS + CS) - CS alone condition]. Dotted line: the time duration of stimulation. MN, median nerve.
fnhum-15-761186-g003.jpg
PMC8591027_02_fnhum-15-761186-g003.jpg
F3
In the s-SEP paradigm, s-SEPs were obtained by stimulation of the right and left median nerves at the wrist (Figures 2, 3). We calculated and compared the average of the SEP from 1 to 250 epochs with those from 251 to 500 epochs (Figures 2, 3).