PMC3012839_01
Levels of biochemical parameters during hospitalization.
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F1
Gradually, the patient's mental status became normal, and liver function, coagulation profiles and other biochemical variables improved notably (Fig. 1).
Initial liver biopsy performed on day 12 of hospitalization. (A) Massive hepatocellular necrosis was mainly located in zone 3 with moderately inflammatory infiltration (Hematoxylin and eosin staining x 200). (B) No obvious deposition of fibrous tissue observed within portal tracts (Masson's trichrome staining x 100).
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F2
Bile ducts appeared normal except for cholangioles with bile plugs (Fig. 2).
Repeat liver biopsy performed 6 months after discharge. (A) Distortion of lobular structure of the liver accompanied by scattered foci of hepatocellular necrosis within lobules and lymphocytic piecemeal necrosis (Hematoxylin and eosin staining x 200). (B) Expanded portal tracts with fibrous septa indicative of postnecrotic hepatic cirrhosis (Masson's trichrome staining x 200).
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F3
The biopsy showed evidence of some swollen hepatocytes and scattered foci of hepatocellular necrosis within the liver lobules (Fig. 3).