PMC10440052_01
Timeline of events and treatments.
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This timeline of events is displayed in Figure 1. Representative images of her brain MRIs are noted in Figure 2, where (1) demonstrates the mass at diagnosis, (2) is post concurrent TMZ and radiation, and (3) is her last brain MRI.
(A) Initial MRI (T2 FLAIR sequence) showing left thalamic lesion consistent with MGMT hypermethylated, IDH1/2 WT. (B) MRI was obtained after completion of concurrent chemoradiation with TMX, followed by maintenance TMZ. (C) Nodular foci of T2 hyperintensity that remained unchanged.. Abbreviations: MRI, magnetic resonance imaging; MGMT, O6-methylguanine-DNA methyl-transferase; TMZ, temozolomide; TMZ - WT, Wild type.
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Representative images of her brain MRIs are noted in Figure 2, where (1) demonstrates the mass at diagnosis, (2) is post concurrent TMZ and radiation, and (3) is her last brain MRI.
(A) Representative image of a monoblast (left) and immature monocyte (right), with fine chromatin, prominent nucleoli, and a small nuclear indentation. (Credit: Cho J. and Venkataraman, G. "Monoblast and immature monocytic cell in peripheral blood" ASH Image Bank, 7/5/2018). (B) Myeloid blasts (CD45 dim, red) are confirmed on flow cytometry and make up 67% of total events. (C) Monocytes (blue/purple) at all stages of maturation express high levels of CD36 and CD64. (D) As monocytes mature, they acquire increasing levels of CD14. This plot demonstrates a major immature population of monocytes (purple) that are lacking CD14.
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The patient was diagnosed with AML with monocytic differentiation (Figure 3).