PMC3420661_01
Showing child with huge hepatomegaly.
CRIM.PATHOLOGY2011-314696.001.jpg
PMC3420661_01_CRIM.PATHOLOGY2011-314696.001.jpg
fig1
Abdominal examination detected hepatomegaly (10 cm) which was firm, smooth, and nontender; without any other organomegaly or ascites (Figure 1).
Showing wrist X-ray with features of active rickets.
CRIM.PATHOLOGY2011-314696.002.jpg
PMC3420661_01_CRIM.PATHOLOGY2011-314696.002.jpg
fig2
Wrist X-ray showed features of active rickets (Figure 2).
Showing histopathology of liver. Liver biopsy detected large pale staining hepatocytes with centrally placed nuclei giving appearance of plant cells and mosaic pattern with fibrous septa extending from portal tracts which as not entirely specific but suggestive of GSD.
CRIM.PATHOLOGY2011-314696.003.jpg
PMC3420661_01_CRIM.PATHOLOGY2011-314696.003.jpg
fig3
Liver biopsy was done which detected large pale staining hepatocytes with centrally placed nuclei giving appearance of plant cells and mosaic pattern with fibrous septa extending from portal tracts which not pathognomonic but suggestive of GSD (Figure 3).
Showing wrist X-ray with features of healing rickets.
CRIM.PATHOLOGY2011-314696.004.jpg
PMC3420661_01_CRIM.PATHOLOGY2011-314696.004.jpg
fig4
Repeated X-ray wrist showed significant recovery from rickets (Figure 4).