PMC10294021_01
Multimodal imaging before and after retinal pigment epithelium (RPE) tear. a, b Near-infrared image and optical coherence tomography (OCT) image prior to RPE tear development. OCT shows a wrinkled RPE band as response to intravitreal aflibercept treatment. Besides, OCT scan reveals a hyperreflective macular neovascularization (MNV) membrane underneath the RPE band and a sub-RPE cleft presenting as hypo-reflective space between the Bruch's membrane and the MNV. c-f Multimodal imaging after intravitreal faricimab injection: color fundus photography shows a depigmented area corresponding to the exposed choroid (star) (c). d RPE tear area appears as sharp hyperreflectivity in near-infrared image (star). e OCT shows the retracted edge of torn RPE and the missing RPE band in the RPE tear area (arrowhead). f Correspondingly, the area of unilobular RPE tear exhibits a markedly reduced fundus autofluorescent signal as RPE cells with fluorescent lipofuscin are lost (arrowhead).
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F1
Despite treatment, the height of the PED increased from 402 microm to 608 microm, and the amount of subretinal fluid became more (Fig. 1a, b). Four weeks after receiving the injection, the patient developed an RPE tear (Fig. 1c-f).