PMC9440669_01
Clinical characteristics of pityriasis lichenoides et varioliformis acuta. Multiple discrete erythematous papules with crusted lesions on the (A) trunk and (B and C) extremities, some healed with varioliform scar.
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Dermatological examination revealed multiple discrete erythematous papules with crusted lesions on the trunk and extremities, and some healed with varioliform scars (Figure 1).
Histopathology of pityriasis lichenoides et varioliformis acuta. (A) Dense superficial and deep perivascular infiltrate and interface dermatitis (H&E 40X), (B) consisting of lymphocytes admixed with extravasated erythrocytes (H&E 100X). (C) Scatter and confluent necrotic keratinocytes, parakeratosis, and exocytosis of lymphocytes into the epidermis (H&E 400X).
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Scatter and confluent necrotic keratinocytes, parakeratosis, and exocytosis of lymphocytes into the epidermis were noted (Figure 2).
Immunohistochemistry of pityriasis lichenoides et varioliformis acuta. Positive (A) CD3, (B) CD4, and (C) CD8 but negative (D) CD30 staining of lymphocytes. (x40 original magnification).
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T cells over CD4-positive T cells and negative for CD 30 staining. (Figure 3). The clinicopathological findings were consistent with PLEVA.
Clinical characteristics of lymphomatoid papulosis. Multiple discrete erythematous-to-brownish papules with some central necrotic crusts on the (A) trunk and (B) extremities.
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Dermatological examination revealed multiple discrete erythematous-to-brownish papules with some central necrotic crusts on the trunk and extremities (Figure 4).
Histopathology of lymphomatoid papulosis type F. (A) Superficial and deep perivascular and perifollicular infiltrate with epidermal hyperplasia and focal hyperkeratosis (H&E 100X). (B) Perifollicular infiltrate of atypical large mononuclear cells with folliculotropism (H&E 400X).
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Skin biopsy obtained from the right arm revealed perifollicular infiltrate of large atypical mononuclear cells with abundant cytoplasm and prominent nuclei admixed with lymphocytes, few neutrophils, and eosinophils with folliculotropism (Figure 5).
Immunohistochemistry of lymphomatoid papulosis type F. Positive (A) CD3, (B) CD4, and (C) CD8 staining of small lymphocytes in perivascular area. (D) Perifollicular and follicular infiltrate of positive CD30 large atypical mononuclear cells (x40 original magnification).
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Immunohistochemistry demonstrated large atypical CD30+ cell infiltrate within the hair follicle and CD3+, CD4+, and CD8+ small lymphocytes in perivascular areas. (Figure 6).