PMC4998242_01
Metaphase fluorescent in situ hybridization (FISH) using the probe in the Smith-Magenis syndrome (SMS, OMIM 182290). The red area shows the control the green gene responsible for SMS. FISH = fluorescent in situ hybridization, SMS = Smith-Magenis syndrome.
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F1
Owing to persistence of tachypnia, mild hypotonia, feeding difficulties, sleep disturbances, and mild dysmorphic facial features observed clearly such as a flat, broad nasal bridge and small mandible, suspicion of genetic abnormalities were considered and blood samples were sent for chromosome analysis and for FISH testing (Figure 1).