PMC3687167_01
Clinical picture showing swelling in the right side angle of mandible
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F1
A 16-year-old male patient reported with a chief complaint of swelling on the right side of the face for the past 2 months [Figure 1].
CT scan showing an osteolytic lesion about 2.5 x 2 cm in dimension extending from the distal aspect of 47 to the ramus of the mandible with destruction of buccal cortical plate
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F2
The clinical and radiologic findings were suggestive of odontogenic tumor [Figures 2a-c].
Photomicrograph showing biphasic nature of myofibroma with elongated spindle cells seen alternating with closely packed cells with small rounded nuclei and eosinophilic cytoplasm forming interlacing fascicles. (H and E, stain x200)
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F3
These cells were seen alternating with closely packed cells with small rounded nuclei and eosinophilic cytoplasm [Figure 3].
Hemangiopericytoma-like vascular pattern is seen. (H and E, stain x100)
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F4
Vascular spaces mimicking the hemangiopericytoma pattern were also observed [Figure 4].
Strong immunoreactivity for alphaSMA in the tumor cells and hemangiopericytoma-like vascular pattern is seen. Note that the blood vessel walls are also positive (x100)
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F5
Positive immunoreactivity was observed for vimentin and alphaSMA [Figures 5 and 6] and negative immunoreactivity for S100, desmin, and CD68, thus confirming the myofibroblastic nature of the tumor.
Photomicrograph demonstrating strong immunoreactivity for alphaSMA in the tumor cells showing a biphasic pattern (x100)
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F6
Positive immunoreactivity was observed for vimentin and alphaSMA [Figures 5 and 6] and negative immunoreactivity for S100, desmin, and CD68, thus confirming the myofibroblastic nature of the tumor.