PMC5006953_01
Temporal progression of intraretinal microvascular abnormality (IRMA) to neovascularization elsewhere (NVE) of a single lesion in diabetic retinopathy over a 14-month period. (First row, left) Infrared image shows an IRMA. (First row, right) Concurrent spectral-domain optical coherence tomography (SD OCT) shows slight outpouching of the internal limiting membrane (ILM) with hyperreflective dots in the inner retina. (Second row, left) Infrared image taken 4 months after image in first row. (Second row, right) On concurrent SD OCT image, there is more distinctive outpouching of the ILM without disruption. (Third row, left) Infrared image taken 5 months after image in second row. (Third row, right) The area of outpouching is larger without disruption of the ILM. (Fourth row, left) Infrared image taken 5 months after image in third row shows fine vessels characteristic of neovascularization. (Fourth row, right) SD OCT image shows evidence of NVE with a breach of the ILM and growth into the posterior hyaloid.
nihms793225f4.jpg
PMC5006953_01_nihms793225f4.jpg
F4
His infrared and OCT images of the initial evaluation showed an IRMA located superotemporal to the disc in the left eye (Figure 4, First row). The initial outpouching of the ILM became more prominent 4 and 9 months later (Figure 4, Second row and Third row). Eventually, this IRMA progressed into an NVE 14 months after the initial evaluation (Figure 4, Fourth row).