PMC6022815_01
Fundus photographs and results of measurement of the macular GCC and cpRNFL obtained from Case 1.. Notes: Fundus photographs of the right (A) and left (B) eyes at initial presentation. Macular GCC maps of the right (C) and left (D) eyes at initial presentation and of the right (E) and left (F) eyes 5 months later. Spectral domain optical coherence tomography was used to measure the thicknesses of the internal limiting membrane, retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer, as well as provide macular GCC maps based on the normative database. On the macular GCC maps, green indicates that the thicknesses are within the normal range, yellow - abnormal below the 5% level, and red - abnormal below the 1% level. Temporal, superior, nasal, inferior, temporal graphs of the thickness of the cpRNFL in the right (G) and left (H) eyes 5 months after the initial presentation.. Abbreviations: GCC, ganglion cell complex; cpRNFL, circumpapillary retinal nerve fiber layer; T, temporal; S, superior, N, nasal; I, inferior.
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The results of a fundus examination were unremarkable in both eyes ("oculus uterque" or OU) (Figure 1A and B). When the GCC thickness was measured by optical coherence tomography (OCT) (RS-3000 Advance OCT; Nidek, Gamagori, Japan), there was a slight reduction in the papillomacular bundles OU (Figure 1C and D). The reduction in the papillomacular bundles worsened during the follow-up period (Figure 1E and F), but no changes in circumpapillary retinal nerve fiber layer (cpRNFL) parameters were observed (Figure 1G and H).
PMC6022815_02
Fundus photographs and results of measurement of the macular GCC and cpRNFL obtained from Case 2.. Notes: Fundus photographs of the right (A) and left (B) eyes at initial presentation. Macular GCC maps of the right (C) and left (D) eyes at the initial presentation and of the right (E) and left (F) eyes 1 month later. Temporal, superior, nasal, inferior, temporal graphs of the thickness of the cpRNFL in the right (G) and left (H) eyes 1 month after the initial presentation.. Abbreviations: GCC, ganglion cell complex; cpRNFL, circumpapillary retinal nerve fiber layer; T, temporal; S, superior, N, nasal; I, inferior.
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OU, except for retinal arteriolosclerosis OU (Figure 2A and B). OCT showed that the reduction in the macular GCC thickness was not apparent at the initial presentation (Figure 2C and D). It became evident 1 month later when both optic disks still appeared normal (Figure 2E and F), but no changes in cpRNFL parameters were observed (Figure 2G and H).
PMC6022815_03
Fundus photographs and results of measurement of the macular GCC and cpRNFL obtained from Case 3.. Notes: Fundus photographs of the right (A) and left (B) eyes at initial presentation. Macular GCC maps of the right (C) and left (D) eyes at initial presentation. Temporal, superior, nasal, inferior, temporal graphs of the thickness of the cpRNFL in the right (E) and left (F) eyes at the initial presentation.. Abbreviations: GCC, ganglion cell complex; cpRNFL, circumpapillary retinal nerve fiber layer; T, temporal; S, superior, N, nasal; I, inferior.
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OU, except for slight optic disk pallor OD (Figure 3A and B). OCT showed decreased papillomacular bundles OU (Figure 3C and D), but no changes in cpRNFL parameters were observed (Figure 3E and F).