PMC6205822_01
A lung SCC patient was identified as harboring ERBB2 20ins and responded to afatinib.. Notes: (A) Hematoxylin-eosin staining revealed the histological appearance of SCC. The green arrow and a green circle indicate typical histological appearance of SCC. (B) Responses of an ERBB2 20ins patient with lung SCC to afatinib. Computed tomography scans of the chest were obtained at baseline and after 3 months treatment of afatinib. The red arrows indicate tumor lesion.. Abbreviations: 20ins, exon 20 insertions; SCC, squamous cell carcinoma.
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SCC (Figure 5A). She was diagnosed with stage IV SCC with bone and brain metastasis. Criteria In Solid Tumors (RECIST) 1.1, evident by tumor shrinkage (Figure 5B) and alleviation of symptoms, such as coughing, thoracalgia, and dyspnea. Collectively, this case is the first report of an SCC patient harboring ERBB2 20ins and showing benefit from afatinib.