PMC7115058_01
Ulcerated lesions located in the lower part of left labia minora in a context of atrophy with a pale pink hue (post biopsy).
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fig1
This lesion occurred in a context of atrophic-like vulva with a pale pink hue (Figure 1).
Histological features of vulval intestinal/enteric heterotopia view. Sharp transition of the normal squamous epithelium into enteric-type in a context of chronic inflammation.
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A biopsy of the lesion was taken and revealed an abrupt transition of the normal squamous epithelium into mucinous enteric-type columnar glandular epithelium in a context of chronic inflammation (Figure 2).
Intestinal/enteric vulval heterotopia. At high power view, some glands were lined by a mucinous columnar epithelium with nuclear stratification, mild atypia, and rare mitosis compatible with either inflammatory or regenerative atypia even if a possible associated low-grade dysplasia cannot be excluded (a). Note the strong positive staining for the CK 20 (b) and CDX2 (c). The CK 7 staining was less marked (d).
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fig3
Staining for ER, PR, GCDFP-15, GATA 3, and PAX-8 was negative (Figure 3).