PMC7234328_01
(a) Papillary structure (20x magnification, hematoxylin-eosin staining). (b) Papillary thyroid cancer nuclear features (pleomorphism, elongation, grooves) (40x magnification, hematoxylin-eosin staining). (c) Islands of moderately differentiated squamous cell carcinoma (20x magnification, hematoxylin-eosin staining). (d) In detail large squamous cells with polygonal shape and large cytoplasms (40x magnification, hematoxylin-eosin staining).
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TGDR, classical type, infiltrating the surrounding soft tissues and the hyoid bone (Figure 1(a) and (b)) and adjacent 1 cm moderately differentiated SCC (Figure 1(c) and (d)) infiltrating the surrounding muscles, with diffuse lymphatic embolism.
(a) Lymph node metastasis of papillary thyroid carcinoma (2x magnification, hematoxylin-eosin staining). (b) Lymph node metastasis of squamous carcinoma (10x magnification, hematoxylin-eosin staining). (c) Thyroglobulin expression of metastasis from papillary thyroid carcinoma (10x magnification, hematoxylin-eosin staining). (d) P40 expression of metastasis from squamous cell carcinoma (10x magnification, hematoxylin-eosin staining).
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The accessory chain harbored 5 lymph nodes with metastasis from SCC; the right lateral compartment also contained 25 lymph nodes with massive metastasis from SCC (Figure 2(b) and (d)) and 2 lymph nodes with mixed metastases from SCC and PTC. The 18 mm lymph node on the jugular vein was a metastasis from PTC (Figure 2(a) and (c)) infiltrating the soft tissues.