PMC6247656_01
Locations and paralogue analysis of SCN11A variants associated with pain diseases in the Nav1.9 channel. The Nav1.9 channel, like other sodium channels, is composed of 24 transmembrane segments organized into four domains. Mutated residues are in bold, black dots represent locations of mutated residues in the channel. Amino acid residue number is given above mutated residue. Paralogue sodium channels along with mutated residues and their numbers are given below equivalent residues in SCN11A.
CRIG2018-6898546.001.jpg
PMC6247656_01_CRIG2018-6898546.001.jpg
fig1
Material, Fig.  S1). Muscle enzymes were within reference ranges.