PMC5772863_01
Focal proliferative IgA nephropathy (Lee grading, III) was diagnosed using electron microscopy. In accordance with the Oxford classification of IgA nephropathy, it was equivalent to M1 E0 S1 T0. IgA, immunoglobulin A.
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In addition, arteriole walls were thickened and a stenosis was identified in the lumen (Fig. 1).
Pathological examination or renal tissue using optical microscopy. (A) Glomerular sclerosis indicated by hematoxylin and eosin staining. (B) Glomerular segmental sclerosis indicated by periodic acid-silver metheramine. (C) Glomerular balloon adhesion indicated by periodic acid-Shiff staining. (D) Immunoglobulin A deposition indicated by immunofluorescence detection of paraffin-embedded sections. Points of interest pertaining to each description are indicated with a red arrow. Magnification, x400.
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Optical microscopy performed on renal biopsy sections (magnification, x400) revealed eight glomeruli, one of which was sclerotic (hematoxylin-eosin staining; Fig. 2A) and another one was segmental sclerotic (periodic acid-silver methenamine; Fig. 2B). Fig. 2C). Furthermore, focal segmental exacerbation, vacuolization and granular degeneration of renal tubular epithelial cells, focal atrophy, renal interstitial focal necrosis and inflammatory cell infiltration were observed. The results of immunofluorescent staining were as follows: IgA positive (2+); and IgM, IgG, C3, C1q negative (Fig. 2D).