PMC6066556_01
(200X magnification). (A) HER-2 immunostain showing overexpression of HER-2 with intense circumferential staining of the tumor cells. (B) Hematoxylin and Eosin stained section showing malignant glands infiltrating adipose tissue.
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F1
However, there was perineural invasion as well as involvement of the SCM (Figure 1). HER-2 staining was performed on the previous surgical specimen and showed overexpression of HER-2 (Figure 1).
(A) Transverse abdominal PET scan before systemic therapy with TDM1, showing FDG avid liver lesion. (B) Transverse abdominal PET scan after treatment, showing disappearance of FDG avid liver lesion.
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F2
Follow up PET scan four months later, showed resolution of the liver metastatic lesion (Figure 2).
(A) Coronal Brain MRI, T1 with contrast showing a hyperintense lesion in the left cerebellar lobe before systemic therapy with TDM1. (B) Coronal Brain MRI, T1 with contrast showing decrease in the size of the lesion after treatment.
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F3
MRI brain revealed a significant decrease in the number and size of the metastatic enhancing brain lesions, in keeping with a good response to treatment (Figure 3).