PMC5703762_01
(A) Histological features of liver biopsy, showing significant anisonucleosis, mild liver cell plate disarray, loss of nuclear polarity, hepatocytes and glycogenated nuclei, and focal macrovesicular steatosis (hematoxylin and eosin stain, 40x magnification). (B) Frequent mitotic figures (arrow) (hematoxylin and eosin stain, 40x magnification). (C) Trichrome stain highlighting peri-centrovenular fibrosis (40x magnification). (D) Trichrome stain highlighting peri-sinusoidal/peri-hepatocellular fibrosis (40x magnification).
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F1
Liver biopsy was remarkable for focal hepatocytes with glycogenated nuclei, 1% macrovesicular steatosis, occasional ceroid macrophages, and significant anisonucleosis with enlarged nuclei, multiple nucleoli, and frequent mitotic figures (Figure 1).