PMC9885878_01
Clinical photograph of a female patient showing improvement in minocycline-induced hyperpigmentation before and after treatment. (A) Before treatment. (B) After three treatments of 35% fruit acids. (C) After three intense pulsed light treatments.
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In summary, the appearance of hyperpigmentation was caused by minocycline based on the time node of the occurrence of adverse drug reactions and the adverse effects of oral minocycline, including the formation of hyperpigmentation, so the minocycline was stopped, and the patient was advised to avoid light (Figure 1A). The wavelength of intense pulsed light we chose was 560, and the doses before and after three times were 15 MJ, 14 MJ, and 16 MJ, respectively, and the endpoint response was a slight deepening of the hyperpigmented area (Figure 1B). After the combined treatment of chemical peeling and intense pulsed light, the patient's facial hyperpigmentation largely subsided (Figure 1C).