PMC5804617_01
Transition of oral oxycodone equivalent narcotic dose, warfarin dose, and PT-INR. Horizontal axis: number of days elapsed since hospitalization (days). Figure top: transition of oral oxycodone equivalent narcotic dose. Vertical axis: oral oxycodone equivalent narcotic dose (mg). Figure bottom: transition of warfarin dose and PT-INR. Vertical axis: warfarin dose (mg) and PT-INR. a The peak of PT-INR after administration of acetaminophen. b The peak of PT-INR after administration of oxycodone. c The plateau of PT-INR after administration of methadone. Methadone was not converted to form a ratio with other opioids; the graph was prepared by converting methadone 15 mg to oral oxycodone 80 mg
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PMC5804617_01_40981_2017_92_Fig1_HTML.jpg
Fig1
We started concomitant administration of oxycodone and acetaminophen under monitoring of the PT-INR because acetaminophen increased the PT-INR to 2.93 (Fig. 1). 