PMC7719490_01
Histopathology of the tumor resected from the skull base of the patient. (a) Hematoxylin and eosin and (b) positive expression of Brachyury in the nucleus of tumor cells.
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The tumor mainly showed conventional histology, namely, epithelioid to spindle cells arranged in anastomosing cords and nests in a myxoid matrix (Figure 1(a), left side). In addition, the tumor partly showed chondroid histology, i.e., singly arranged tumor cells within the chondroid matrix (Figure 1(a), right side). Immunohistochemically, tumor cells in both areas were positive for AE1/3, epithelial membrane antigen (EMA), S100, and Brachyury (Figure 1(b)).
18F-FDG-PET/CT scan at first presentation. 18FDG uptake in (a) skull base and C6 and (b) T12.
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Positron emission tomography (PET) and magnetic resonance imaging (MRI) of the whole spine revealed lesions at C6 and T12 (Figures 2 and 3).
MRI at first presentation. (a) Sagittal image of tumors at skull base and C6, axial image of tumor at (b) skull base and (c) C6, and (d) sagittal and (e) axial images of the tumor at T12.
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Positron emission tomography (PET) and magnetic resonance imaging (MRI) of the whole spine revealed lesions at C6 and T12 (Figures 2 and 3).