PMC8027102_01
Clinical features of the hand lesions. (A, B) Contracture deformity of both hands was evident, and an ulcer was detected on the flexor side of the 5th metacarpophalangeal joint of the left hand.
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Physical examination showed a 2.0 x 1.0 cm red ulcer on the flexor side of the 5th metacarpophalangeal joint of the left hand ( Figures 1A, B ).
Histopathology of the hand lesion. HE staining of the tissue (panel A was from the edge of the ulcer, panel B was from the ulcer) revealed atypical squamous cell proliferation and horn pearls in the dermis (H&Ex100, x10). Immunohistochemical staining of the biopsy specimen showed (C, D) the squamous cells were positive for pan cytokeratin and negative for vimentin (x100).
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Well differentiated SCC was diagnosed ( Figure 2 ).
Timeline of the disease's development.
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The patient has been followed-up for 8 years and has remained free of recurrence of the SCC ( Figure 3 ).