PMC7333039_01
Ileum. (a) Hypertrophy of muscularis propria (magnification 10x, H&E). (b) Focally absent ganglion cells (magnification 20x, S100). (c) Auerbach's plexus highlighted in dark brown (magnification 10x, S-100). (d) Numerous ganglion cells in some areas (magnification 20x, S100).
CRIGM2020-1272567.001.jpg
PMC7333039_01_CRIGM2020-1272567.001.jpg
fig1
Full-thickness sections from the ileum (Figure 1), cecum (Figure 2), appendix, colon, sigmoid, and rectum (Figures 3 and 4) were obtained and stained with hematoxylin and eosin (H&E), calretinin, and for S-100, a neuronal marker.
Cecum. (a) Reduced ganglion cells (magnification 40x, H&E). (b) Reduced ganglion cells (magnification 40x, S100).
CRIGM2020-1272567.002.jpg
PMC7333039_01_CRIGM2020-1272567.002.jpg
fig2
Full-thickness sections from the ileum (Figure 1), cecum (Figure 2), appendix, colon, sigmoid, and rectum (Figures 3 and 4) were obtained and stained with hematoxylin and eosin (H&E), calretinin, and for S-100, a neuronal marker.
Hypertrophy of the muscularis propria in rectum and sigmoid sections. (a) Rectum (magnification 10x, H&E). (b) Sigmoid colon (magnification 10x, H&E).
CRIGM2020-1272567.003.jpg
PMC7333039_01_CRIGM2020-1272567.003.jpg
fig3
Full-thickness sections from the ileum (Figure 1), cecum (Figure 2), appendix, colon, sigmoid, and rectum (Figures 3 and 4) were obtained and stained with hematoxylin and eosin (H&E), calretinin, and for S-100, a neuronal marker.
Sigmoid colon. (a) Focally absent ganglion cells (magnification 40x, H&E). (b) Focally absent ganglion cells (magnification 40x, S100).
CRIGM2020-1272567.004.jpg
PMC7333039_01_CRIGM2020-1272567.004.jpg
fig4
Full-thickness sections from the ileum (Figure 1), cecum (Figure 2), appendix, colon, sigmoid, and rectum (Figures 3 and 4) were obtained and stained with hematoxylin and eosin (H&E), calretinin, and for S-100, a neuronal marker.