PMC3883272_01
59-year-old man presented with a 10-month history of pain and swelling inthe left maxillary sinus diagnosed with Brown tumor associated with tertiary parathyroidism. (October 14, 2010) Axial maxillofacial computed tomography scan shows a lesion on the floor of the left maxillary sinus extending through the nasal cavity (red arrows), infratemporal fossa (blue arrows), pterygopalatine fossa (green arrows), and premaxillary region (yellow arrows). The expansion of the left maxillary sinus is visible.
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F1
The mass was slightly hyperdense with adjacent soft tissue on contrast-enhanced maxillofacial CT scan [Figure 1].
59-year-old man presented with a 10-month history of pain and swelling inthe left maxillary sinus diagnosed with Brown tumor associated with tertiary parathyroidism. Histopathologic slide shows multiple giant cells (black arrow) with spindle-shaped stromal cells, fibrous connective tissue (red arrow) proliferation, and areas of hemorrhage (yellow arrow) (H and E, x 40).
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F2
The incisional biopsy followed by histopathologic investigation of the excised mass revealed a lesion with regions of discrete bone resorption with osteoclast activity, fibroblasts with areas of hemorrahage, and multinucleated giant cells [Figure 2].
59-year-old man presented with a 10-month history of pain and swelling in the left maxillary sinus diagnosed with Brown tumor associated with tertiary parathyroidism. (January 30, 2013) 27-month post-treatment (a) axial and (b) coronal maxillofacial computed tomography images reveal thickening of bone walls of the lesion with a reduction of the tumor volume (arrow) and increase in the density of the lesion.
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F3
CT scan (in January, 2013) 27-months post-treatment showed thickened cortical bone of the tumor walls, decreased tumor size, and increased density of the lesion matrix [Figure 3].