PMC2988226_01
a Ultrasonography at 35 weeks' gestation, showing orbital mass (arrowhead) and displaced eyeball (arrow). b Clinical photograph taken on day 1 of life, showing a huge mass in the right orbit and proptosis. Axial T1 (c), axial T2 (d), and sagittal T1 (e) magnetic resonance imaging of the orbit after gadolinium injection; well-enhanced and marginated heterogeneous tumor without intracranial extension is seen.
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F1
A newborn girl presented with massive proptosis of the right eye, which was identified as secondary to an orbital mass found at 35 weeks of gestation by prenatal ultrasonography (fig. 1 a). A large, firm mass completely filled the right orbit and was associated with hemorrhage (fig. 1 b). Magnetic resonance imaging of the head and orbits revealed a large, well-delineated right orbital mass with no evidence of surrounding bony erosion or intracranial extension (fig. 1 c-e).
a Light microscopy image of the orbital tumor, showing sheets of polygonal and spindle cells with vesicular nuclei, prominent nucleoli, and eosinophilic cytoplasmic inclusions. H.E. Original magnification, x400. b Immunohistochemical analysis showing tumor cells positive for MIC-2 (CD99). Original magnification, x400.
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F2
There were abundant amphophilic or faintly eosinophilic cytoplasmic inclusions (fig. 2a). A (fig. 2b). All of these findings were consistent with a diagnosis of MRT.
PMC2988226_02
Autopsy findings of tumor recurrence at exenterated site (top left), pons (top right), posterior aspect of the lung (bottom left), liver (bottom center), and retroperitoneum (bottom right).
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F3
The masses were firm, irregular shaped, and fixed to adjacent organs (fig. 3).