PMC4763580_01
(a and b) Multiple non healing ulcers over the shin
IDOJ-7-43-g001.jpg
PMC4763580_01_IDOJ-7-43-g001.jpg
F1
Three similar ulcers [Figure 1a and b] appeared on the shin over the next one month.
(a-c) Hyperplastic, sclerotic epidermis and a dense superficial and deep dermal infiltrate of lymphocyte and plasma cells concentrated around the blood vessels and sweat glands with several granulomas arranged in a horizontal manner in mid and lower dermis. (H and E, x10, x40, x40)
IDOJ-7-43-g002.jpg
PMC4763580_01_IDOJ-7-43-g002.jpg
F2
Skin biopsy from the edge of the ulcer revealed a hyperplastic, sclerotic epidermis and a dense superficial and deep dermal infiltrate of lymphocyte and plasma cells concentrated around the blood vessels and sweat glands [Figure 2a-c].
(a and b) Complete healing and softening of skin after treatment with thalidomide
IDOJ-7-43-g003.jpg
PMC4763580_01_IDOJ-7-43-g003.jpg
F3
Pain reduced dramatically within 2 weeks and the ulcers healed completely after 4 weeks [Figures 3a and b].