PMC8415779_01
Changes in haemoglobin (Hb), alanine transaminase (ALT), lactate dehydrogenase (LDH), total bilirubin (TBIL), blood urea nitrogen (BUN), and creatinine (Cr) levels during cefoperazone-tazobactam and cefoperazone-sulbactam treatment. On the 9th day of hospitalization, therapeutic plasma exchange (TPE) with 2,100 mL of frozen plasma and bilirubin adsorption treatment were performed. On days 13 and 14, leukocyte-reduced red blood cells (LRBCs) prepared from 1,200 mL of whole blood were infused. On day 24, TPE with 2,000 mL of frozen plasma and bilirubin adsorption treatment were performed. On day 67 of hospitalization, 1,050 mL of frozen plasma and LRBCs prepared from 1,200 mL of whole blood were used for whole blood replacement therapy, and continuous renal replacement therapy was started. On day 69, TPE was performed using 4,100 mL of frozen plasma, followed by red blood cell exchange treatment with LRBCs prepared from 1,400 mL of whole blood. On day 70, TPE was repeated with 4,000 mL of frozen plasma, and LRBCs prepared from 400 mL of whole blood were infused. On the 71st day of hospitalization, washed red blood cells prepared from 800 mL of whole blood were infused.
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F1
The dynamics of Hb, LDH, total bilirubin, alanine transaminase, BUN, creatinine, and cefoperazone-tazobactam and cefoperazone-sulbactam administration are shown in Figure 1.