PMC7669509_01
Chest CT scans (26.03.2020) were performed and images were recorded prior to any therapies. A 48 x 36 mm size lesion in the right lung lower lobe, a 78 x 45 mm size lesion in the left lung lower lobe. (A) Lung window. (B) Mediastinal window. Red arrows point to the lung tumor.
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Chest computed tomography (CT) revealed two solid lesions located at the lower lobes of the right lung (48 x 36 mm) and left lung (78 x 45 mm) (Figure 1), suggesting the possibility of a malignant tumor.
Immunohistochemical examination: (A) Hematoxylin and Eosin staining revealed the bottom lobe of the left lung was SCC, and it was positive for (B) P40, (C) P63, (D) Ki-67 (80%), and negative for CD56, Syn, cgA, TTF-1. (E) Hematoxylin and Eosin staining revealed the bottom lobe of the right lung was SCLC and the tumor cells were positive for (F) CD56, (G) Syn, (H) cgA, (I) TTF-1, (J) Ki-67 (90%), and negative for P40, P63.
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TTF-1. The right lung lower lobe tumor was diagnosed as SCLC; tumor cells were positive for CD56, Syn, cgA, TTF-1, and Ki-67 (90%) and negative for P40 and P63 (Figure 2).
Chest CT scans (05.06.2020) after systemic chemotherapy with carboplatin and etoposide. Dramatic shrinkage of the right lung lower lobe tumor from 48 x 36 mm to 30 x 15 mm. Dramatic shrinkage of the left lung lower lobe lesion from 78 x 45 mm to 29.1 x 18.7 mm. (A) Lung window. (B) Mediastinal window.  Red arrows point to the lung tumor.
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The left lung lower lobe tumor also showed from 78 x 45 mm to 29.1 x 18.7 mm (Figure 3).