PMC9929649_01
CT scan of the chest revealing desmoid tumor originating from intercostal musculature and invading the central aspect of the left breast implant. The desmoid tumor is marked with a white arrowhead.
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F1
Given her worsening heart failure, the patient was being evaluated for cardiac transplant and obtained a CT of the chest which demonstrated a 5.7 x 4.3 cm hypodense mass of the left chest wall and left axillary adenopathy (Fig. 1).
Intraoperative photos of the desmoid tumor of the left chest. The tumor was smooth, fungating from the intercostal space and extending into the substance of the left breast implant. Excised mass is featured in the inset image next to a ruler to show its dimensions.
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F2
It was excised at the base for biopsy (Fig. 2).
Desmoid-type fibromatosis. H&E. x100 (a) and H&E. x200 (b): bland spindle cell proliferation composed of elongated nuclei with prominent nucleoli arranged in long sweeping fascicles. c Smooth muscle actin immunohistochemistry, x200: shows diffuse cytoplasmic and membranous expression. d Beta-catenin immunohistochemistry, x200: shows nuclear localization, characteristic of desmoid type fibromatosis.
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F3
Immunohistochemical staining for beta-catenin demonstrated diffuse nuclear localization of the protein in keeping with a diagnosis of desmoid type fibromatosis (Fig. 3).