PMC6008617_01
Anesthetic record. The black line indicates heart rate (HR) and the red lines indicate blood pressure (BP). a: six hundred mL of blood loss within 20 minutes, b: six hundred and fifty mL of blood loss within 30 minutes, c: administration of 0.1 mg phenylephrine, x: start or end of anesthesia,  : start or end of the surgery, T: tracheal intubation, E: extubation, TCI: target-controlled infusion, and FFP: fresh frozen plasma.
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fig1
Propofol was continuously infused intravenously at a target concentration of 2 to 4 mug/ml (Figure 1) and BIS levels were maintained between 40 and 60. Regarding hemodynamics, when 600 ml of blood was rapidly lost within 20 minutes, blood pressure decreased from 113/66 to 93/55 mmHg and heart rate increased from 55 to 70 bpm (Figure 1 a). Similarly, when 850 ml of blood was lost within 30 minutes, systolic blood pressure decreased from 108/65 to 95/60 mmHg and heart rate increased from 66 to 74 bpm (Figure 1 b). Administration of 0.1 mg of phenylephrine increased blood pressure from 87/55 to 117/76 mmHg and decreased heart rate from 70 to 65 bpm (Figure 1 c).