PMC5207432_01
WBC gradually increased postoperatively.. Notes: "A" represents the day the patient took hydroxyurea 0.5 g tid po; "B" represents the day the patient took hydroxyurea 1.0 g tid po; "C" represents the day the patient took hydroxyurea 2.0 g bid po; "D" represents the day the patient took hydroxyurea 1.0 g tid po; "E" represents the day the patient did not take the hydroxyurea; "F" represents the day the patient took hydroxyurea 1.0 g tid po. The patient was discharged on March 30, 2015.. Abbreviations: bid, twice daily; po, per os; tid, three times a day; WBC, white blood cell.
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However, the patient's white blood cells (WBCs) increased gradually without fever or use of medications, such as granulocyte colony-stimulating factor (G-CSF) and steroids, after the end of the second course (Figure 1), and neutrophils accounted for ~93%.
Bone marrow biopsy (hematoxylin and eosin 10x40).
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Next, a bone marrow biopsy was performed; the results showed myeloid and erythroid focal hyperplasia and significant partial immature myeloid cell proliferation (Figure 2).
Immunohistochemistry (MPO 10x40).. Abbreviation: MPO, myeloperoxidase.
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Immunohistochemistry showed individual lymphocytes CD3 (+), individual lymphocytes CD20 (+), erythroid CD235a (+), megakaryocytes CD61 (+), CD34 (-), individual monocytes CD14 (+), individual plasma cells CD138 (+), a large number of myeloid myeloperoxidase (MPO) (+) (Figure 3).