PMC5383939_01
A: Upon admission to the hospital, patient 1 was only able to take a few steps and had been wheelchair-bound for the past four months. In addition, his upper extremities had been paralyzed for over twelve months. In the preceding months, the patient's speech had degenerated, and the patient had difficulty swallowing both solid food and liquids, including saliva.
B: On the 2
nd and 3
rd treatment days, patient 1 reported that he was able to lie in bed without experiencing muscle pain in the neck, shoulders, or back. On day 4, the patient was able to stand from a sitting position. On day 5, the patient was able to walk unaided a distance of approximately 100 meters. During days 76 to 91 the patient experienced increasing muscle pain in the neck, shoulders, or back, his walking ability regressed, and the patient became wheelchair-bound again. His swallowing and speech remained functional.
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In addition, his upper extremities had been paralyzed for over twelve months (see Figure 1A). On day 5, the patient was able to walk unaided a distance of approximately 100 meters (see Figure 1B).
The clinical progression and effect of treatment in Patient 1.
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 Figure 2 shows the progression of symptoms and the effect of treatment.
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The clinical progression and effect of treatment in Patient 2.
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Figure 3 shows the progression of symptoms and the effect of treatment in Patient 2.
PMC5383939_03
The clinical progression and effect of treatment in Patient 3.
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 Figure 4 shows this patient's progression of symptoms and the effect of treatment.