PMC9853929_01
(A) Pleomorphic adenoma in left nasal septum (black arrow); left middle turbinate (blue arrow). (B) Gross picture of excised mass from left nasal septum.
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Smooth, rounded, firm, polypoidal bleeding mass of about 3 x 3 cm2 arising from cartilaginous part of nasal septum of left nostril was excised and sent for histopathological examination (Fig. 1).
Histology section using hematoxylin and eosin staining. (A) Cellular tumor arranged in sheets (black arrow); sebaceous differentiation (blue arrow). (B) Intact respiratory lining epithelium (black arrow); tubules containing eosinophilic acellular secretion (blue arrow). (C) Areas of myxoid matrix (black arrow); myoepithelial cells melting in myxoid stroma (blue arrow). (D) Squamous differentiation.
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The tumor cells were arranged predominantly in sheets, focally in tubules and trabeculae with an overlying intact respiratory lining epithelium (Fig. 2A and B). Multiple areas of myxoid matrix are identified with the myoepithelial cells seen to be melting in the myxoid stroma (Fig. 2C). Some areas of abrupt squamous differentiation and sebaceous differentiation were also identified (Fig. 2D and A).