PMC3261598_01
(a) Contrast-enhanced axial CT through the penis demonstrates a low attenuating lesion in the corpora of the penis with peripheral enhancement. No inguinal lymphadenopathy present. (b) F18-FDG PET image fused with corresponding CT demonstrates increased FDG uptake in the periphery of an ill-defined lesion within the corpora of the penis. (c) Histopathological examination shows tumor composed of spindle cells with hyperchromatic nuclei, inconspicuous nucleoli with frequent mitoses (d) Histopathological examination shows positivity for smooth muscle antigen
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F1
Tumor cells also stained positive for smooth muscle antigen (SMA) consistent with diagnosis of leiomyosarcoma of penis [Figures 1c and 1d]. This mass showed slightly thick, peripheral rim enhancement on the contrast-enhanced CT images corresponding to an area of increased F-18 FDG uptake, with an internal homogeneous region of low density, compared to the adjacent normal shaft of the penis, representing residual disease [Figures 1a and 1b].