PMC4157055_01
(A) Pre-operative office-based flexible laryngoscopy demonstrating a large submucosal mass centered within left aryepiglottic fold with inferior extension to the false fold and lateral obliteration of the adjacent piriform sinus. (B) Axial CT-scan with contrast. (C) Representative coronal and (D) axial MRI images.
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A). A CT scan of the head and neck revealed a well-circumscribed low-attenuated mass without contrast enhancement; axial and coronal MRI demonstrated contrast enhancement on T1-weighted images (Figure 1B & C).
Histology: The supraglottic biopsy consists of bundles of spindle cells set within a loose myxoid to collagenous stroma. At high power (inset), the spindle cells are associated with coarse collagen bundles and have hyperchromatic buckled nuclei characteristic of neurofibroma. (Hematoxylin and eosin 100x; inset 400x).
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Pathologic analysis of the mass confirmed the diagnosis of LNF (Figure 2).
Post-operative laryngoscopy: (A) 3-month and (B) 6-month.
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Figure 3 shows the post-operative endoscopy at 3-months (left) and 6-months (right).