PMC4211464_01
Group A beta-hemolytic streptococci with involvement of the deeper layers of the skin and subcutaneous tissue, spreading across the fascial planes of the subcutis.
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F1
In spite of relevant antibiotic treatment, the clinical condition rapidly deteriorated with involvement of the deeper layers of the skin and subcutaneous tissue, spreading across the fascial planes of the subcutis (Figure 1).
Diffuse proliferative glomerulonephritis with approximately 40% halfmoons. Significant tubulus atrophy and interstitial fibrosis with inflammation. Endocapillary glomerulonephritis, with accumulation of endothelial cells and inflammatory cells in the capillary lumina. Changes compatible with acute post-streptococcal glomerulonephritis. No signs of systemic disease or vasculitis.
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F2
Using immunofluorescence techniques, granular deposits of IgG and C3 were identified as typically seen in acute post-streptococcal glomerulonephritis (APSGN) (Figure 2).