PMC8349010_01
Chest CT images in case 1 (A, B) and case 2 (C, D). A, Chest CT images in case 1 at admission showed patchy consolidation, ground-glass opacities (GGO. ) and traction bronchiectasis predominantly in bilateral lower lobes. B, Chest CT images in case. 1 showed improvement of consolidation and GGO after two sessions plasma exchange (PE) with intensive immunosuppressive treatment compared to those of admission. C, Chest CT images in case 2 at admission showed bilateral consolidations and GGO in bilateral lower lobes. D, Chest CT images in case 2 after 1st session of PE showed improvement of both consolidation and GGO compared to those of admission.
gr1.jpg
PMC8349010_02_gr1.jpg
fig1
Chest HRCT revealed bilateral consolidations and GGO consistent with interstitial pneumonia due to dermatomyositis (Fig. 1C). The chest interstitial shadows with consolidation and GGO on HRCT improved after the first PE session (Fig. 1D).
Improvement in titers of anti-MDA5 Ab and serum KL-6 and ferritin values after PE. Clinical parameters (serum titers of anti. -MDA5 Ab, KL-6 and ferritin) for RP-ILD with anti. -MDA5 Ab were promptly decreased after both 1st and 2nd session of PE.
gr2.jpg
PMC8349010_02_gr2.jpg
fig2
Ab and KL-6 levels were promptly decreased to the normal range (Fig. 2, Fig. 3). Although serum KL-6 levels re-increased after 2 sessions of PE, there was no evidence for newly appearance of interstitial shadow.
Clinical course and changes in parameters of Case 1 (a) and Case 2 (b). Serum titers of anti. -MDA5 Ab, KL-6 and ferritin, and the therapeutic interventions were shown. After 2 sessions of PE, blood parameters were maintained to be stable as well as improvement clinical symptoms.
gr3.jpg
PMC8349010_02_gr3.jpg
fig3
After the first PE session, the anti-MDA5 Ab, ferritin, KL-6, IL-6, IL-8, and IL-18 blood levels were decreased to 300 index, 53.6 ng/ml, 206 U/mL, 8.0 pg/ml, 13.4 pg/ml, and 305 pg/ml, respectively (Fig. 3).
PMC8349010_02
Chest CT images in case 1 (A, B) and case 2 (C, D). A, Chest CT images in case 1 at admission showed patchy consolidation, ground-glass opacities (GGO. ) and traction bronchiectasis predominantly in bilateral lower lobes. B, Chest CT images in case. 1 showed improvement of consolidation and GGO after two sessions plasma exchange (PE) with intensive immunosuppressive treatment compared to those of admission. C, Chest CT images in case 2 at admission showed bilateral consolidations and GGO in bilateral lower lobes. D, Chest CT images in case 2 after 1st session of PE showed improvement of both consolidation and GGO compared to those of admission.
gr1.jpg
PMC8349010_02_gr1.jpg
fig1
Chest HRCT revealed bilateral consolidations and GGO consistent with interstitial pneumonia due to dermatomyositis (Fig. 1C). The chest interstitial shadows with consolidation and GGO on HRCT improved after the first PE session (Fig. 1D).
Improvement in titers of anti-MDA5 Ab and serum KL-6 and ferritin values after PE. Clinical parameters (serum titers of anti. -MDA5 Ab, KL-6 and ferritin) for RP-ILD with anti. -MDA5 Ab were promptly decreased after both 1st and 2nd session of PE.
gr2.jpg
PMC8349010_02_gr2.jpg
fig2
Ab and KL-6 levels were promptly decreased to the normal range (Fig. 2, Fig. 3). Although serum KL-6 levels re-increased after 2 sessions of PE, there was no evidence for newly appearance of interstitial shadow.
Clinical course and changes in parameters of Case 1 (a) and Case 2 (b). Serum titers of anti. -MDA5 Ab, KL-6 and ferritin, and the therapeutic interventions were shown. After 2 sessions of PE, blood parameters were maintained to be stable as well as improvement clinical symptoms.
gr3.jpg
PMC8349010_02_gr3.jpg
fig3
After the first PE session, the anti-MDA5 Ab, ferritin, KL-6, IL-6, IL-8, and IL-18 blood levels were decreased to 300 index, 53.6 ng/ml, 206 U/mL, 8.0 pg/ml, 13.4 pg/ml, and 305 pg/ml, respectively (Fig. 3).