PMC5813918_01
A 56-year-old woman with neurofibroma of the right sulcus: (a) US reveals a solid mass, oval-shaped, with circumscribed margins; the mass abuts the chest wall without signs of infiltrations (arrows). (b) Colour-Doppler shows high vascularity.
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An ultrasound (US) examination conducted at our hospital revealed a highly vascular hypoechoic round lesion of 3 cm, with smooth well-defined margins, deeply seated under the muscular aponeurotic fascia (Figure 1).
A 56-year-old woman with neurofibroma of the right sulcus: (a) T2W axial MR images demonstrate the mass is heterogeneously hyperintense compared to muscles and hypointense compared to fat tissues. The mass is within the breast but seated under the muscular aponeurotic fascia (arrow). (b) and (c) Axial T1W images with fat suppression; before gadolinium injection, the mass appears hypointense, with well-defined margins; (c) after gadolinium injection, the mass shows a heterogeneous enhancement.
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Contrast enhancement was highly heterogeneous (Figure 2).
Spindle cell lesion composed of slender fibroblast-like cells with storiform pattern and very low amount of stroma.
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Histopathologic analysis of the mass revealed a spindle cell lesion composed of fibroblast-like cells arranged in storiform pattern with little stroma, no features of malignancy and no mitoses (Figure 3).
Focal and weak immunoreactivity for S-100 protein.
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Immunohistochemistry revealed the positivity of the neoplastic cells for p75 and S-100 protein (Figure 4), markers of neural origin, and a negativity for markers of vascular, muscular and epithelial origin such as CD31, CD34, desmin, smooth muscle actin and cytokeratins.