PMC3325746_01
A) Adenocarcinoma seen in the cervical biopsy prior to treatment. Neoplasia with villoglandular architecture with low grade nuclei and signs of mucin secretion (hematoxylin-eosin; original magnification x100); B) Endometrial adenocarcinoma after treatment showing glandular and cribriform architecture and intraglandular foci of necrosis (hematoxylin-eosin; original magnification x100).
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F1
Biopsy analysis revealed an endocervical adenocarcinoma, histological grade 1 (Figure 1A). The residual tumor was classified as a grade 2 endometrioid adenocarcinoma, which was positive for estrogen and progesterone receptors and vimentin (Figure 1B).
A,B) Sagittal and coronal T2-weighted images that demonstrate masses in both the endometrial cavity and the endocervical canal; each is associated with distinct signal intensities; C) apparent diffusion coefficient (ADC) maps generated prior to treatment.
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F2
Regions of interest were identified by MRI and indicated with white boxes within the ADC maps, and ADC values associated with these regions were 0.72+-0.18x10-3 mm2/s (Figure 2C) for the endometrial tumor and 0.59+-0.12x10-3 mm2/s for the cervical tumor (Figure 2C). Figures 2A and 2B, representing the sagittal and coronal T2-weighted images that demonstrate both masses, were present in both the endometrial cavity and the endocervical canal.