PMC3271840_01
Skin symptoms. The right 5th toe was swollen and had a purple-reddish color (a). A crusted ulcer was present on the ventral side of the toe (b).
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F1
An ulcer 5 mm in diameter, covered with a crust and accompanied by pain and numbness was noted at the toe tip (fig.1a, b).
Histopathological findings (hematoxylin and eosin staining). Hyperkeratosis, parakeratosis, and a partial defect were noted in the epidermis. Inflammatory cells infiltrated around dermal blood vessels (a) (x40), and the blood vessels were partially dilated and contained platelet thrombi (b) (x400).
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F2
Histopathological examination of the ulcerated skin showed that the epidermis was partially defective, platelet thrombi were present in dilated small blood vessels in the upper to middle dermis, and inflammatory cells had infiltrated around the small vessels (fig.2a). The inner wall was destroyed in some blood vessels and the structure was unclear with complete obstruction of the lumen (fig.2b).