PMC7435328_01
Preoperative clinical picture showing 3 x 3cm swelling in the hard palate.
f1000research-9-25478-g0000.jpg
PMC7435328_01_f1000research-9-25478-g0000.jpg
f1
A 59-year-old female patient presented to the outpatient clinic in the Oral and Maxillofacial Surgery Department, Cairo University in January 2019 complaining of a large painless swelling in the hard palate ( Figure 1).
Hematoxylin and eosin-stained sections showing epithelioid cells forming meningiothelial whorls (magnification, x100).. Indistinct cell membranes with uniform nuclei and no mitotic figures (inset; magnification, x200).
f1000research-9-25478-g0001.jpg
PMC7435328_01_f1000research-9-25478-g0001.jpg
f2
The cells exhibited round to oval nuclei ( Figure 2).
Hematoxylin and eosin-stained sections showing syncytial cells (magnification, x100).. Psammoma bodies seen between meningiothelial cells (inset), (x200).
f1000research-9-25478-g0002.jpg
PMC7435328_01_f1000research-9-25478-g0002.jpg
f3
Psammoma bodies were also present ( Figure 3).
Meningioma tumor cells showing a positive cytoplasmic immunohistochemical reaction for (
a) epithelial membrane antigen and (
b) Vimentin (magnification, x200).
f1000research-9-25478-g0003.jpg
PMC7435328_01_f1000research-9-25478-g0003.jpg
f4
Cells were positively stained using primary antibodies for epithelial membrane antigen (EMA) and vimentin ( Figure 4a, b), but were not stained when using primary antibodies for S100, pancytokeratin, p63, chromogranin and renal cell carcinoma glycoprotein ( Figure 5a-e).
Meningioma tumor cells react negatively following immunohistochemical staining for (
a) renal cell carcinoma glycoprotein, (
b) S100, (
c) chromoginin, (
d) p63, (
e) PanCK (magnification, x100).
f1000research-9-25478-g0004.jpg
PMC7435328_01_f1000research-9-25478-g0004.jpg
f5
Cells were positively stained using primary antibodies for epithelial membrane antigen (EMA) and vimentin ( Figure 4a, b), but were not stained when using primary antibodies for S100, pancytokeratin, p63, chromogranin and renal cell carcinoma glycoprotein ( Figure 5a-e).