PMC5954348_01
Sarcoma forming cellular fascicles is seen in the stroma of the tongue, focally invading the intrinsic muscle (left upper corner).. The surface squamous epithelium shows no dysplastic field change or connection with sarcoma. (H&E stain; magnification, x20).
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No osseous, chondroid or rhadomyomatous differentiation was seen on haematoxylin and eosin staining ( Figure 1- Figure 3).
The sarcoma tumor cells possessed enlarged, elongated, pleomorphic and hyperchromatic nuclei, distinct nucleoli and small amount of cytoplasm.. Mitotic figures were frequently noted. No osseous, chondroid or rhadomyomatous differentiation was seen. (H&E stain; magnification, x400).
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No osseous, chondroid or rhadomyomatous differentiation was seen on haematoxylin and eosin staining ( Figure 1- Figure 3).
A Circos plot showing somatic genetic variations.. An ideogram of a normal karyotype is shown in the outermost ring. Chromosomes are segmented into contiguous bins of 1 Mb in size. The second ring from outside shows CNVs at corresponding chromosomal positions. Distinct heights of red dots indicate different inferred copy numbers. Regions that are not covered by any dots have a copy number of two. The third ring shows SNV density. Purple dots with different heights indicate SNV densities of the corresponding regions. The innermost ring shows positions of genes with non-synonymous mutations found in the undifferentiated sarcoma. CNV, copy number variation; SNV, single nucleotide variant.
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