PMC6016157_01
Fundus photographs, fundus autofluorescence imaging (FAF), and optical coherence tomography (OCT) images obtained during the first examination. (a) Fundus photograph showed a tiny, yellowish spot in the bilateral fovea. (b) FAF showed no abnormalities in either of the eyes. (c) OCT showed a diffused and elevated ellipsoid zone and disrupted interdigitation zone in both foveal areas.
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Fundus examinations showed a tiny, yellowish spot in the fovea bilaterally (Figure 1(a)). FAF (Spectralis HRA; Heidelberg Engineering, Heidelberg, Germany) (Figure 1(b)), fluorescein angiography, and indocyanine green angiography all indicated that there were no remarkable abnormalities in either of the eyes. OCT (Cirrus HD-OCT; Carl Zeiss Meditec AG, Dublin, CA, USA) images showed an elevated and blurred ellipsoid zone along with loss of the interdigitation zone at the foveal area bilaterally (Figure 1(c)). There was also no vitreomacular adhesion or traction seen in either of the eyes (Figure 1(c)).
Optical coherence tomography (OCT) images during the follow-up examinations. (a-e) OCT images at 2 (a), 4 (b), 9 (c), 12 (d), and 21 (e) weeks after beginning prednisolone therapy. Ellipsoid zone elevation was improved in both eyes after 2 weeks. Diffused ellipsoid zone gradually improved and became almost normal after 4 weeks in the right eye and after 21 weeks in the left eye. There was observation of the disrupted interdigitation zone after 12 weeks in the right eye and after 21 weeks in the left eye.
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However, loss of the interdigitation zone was observed after 12 weeks in the right eye and after 21 weeks in the left eye (Figure 2).