PMC3923505_01
Sequential change of T2-weighted MRI (upper column), Gd-enhanced T1-weighted MRI (middle column) and F-BPA-PET (lower column) of Case 1, a 44-year-old male. The timing of the MRIs is depicted above the MRIs. F-BPA-PET images were taken just before the BNCT and at 1 month and 10 months after the BNCT. These PET images show the gradual decrease of the tracer uptake as a promising effect of the BNCT. BV was started 10 months after the BNCT, and the MRI showed marked improvement of both perifocal edema and contrast enhancements by BV treatment.
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F1
Upon referral, MRI showed a slightly enhanced lesion with mild perifocal edema (Figure  1). BPA positron emission tomography (F-BPA-PET) image showed marked tracer uptake in the left parietofrontal region (Figure  1), with a 6.0 lesion/normal (L/N) brain ratio of the tracer, indicating that the lesion was a highly malignant tumor. F-BPA-PET showed a favorable decrease of tracer uptake (Figure  1, lower panel). F-BPA-PET was originally developed to estimate the absorbed dose in BNCT, as described above .
PMC3923505_02
Sequential change of T2-weighted MRI (upper column), Gd-enhanced T1-weighted MRI (middle column) and F-BPA-PET (lower column) of Case 2, a 41-year-old man. The timing of the MRI is depicted above the MRI. F-BPA-PET images were taken just before the BNCT, 1 month after and 12 months after the BNCT. These PET images show the gradual decrease of the tracer uptake as a promising effect of BNCT. BV was started 13 months after the BNCT, and an MRI showed a marked positive effect of the BV treatment on the perifocal edema and contrast enhancements.
1748-717X-9-6-2.jpg
PMC3923505_02_1748-717X-9-6-2.jpg
F2
MRI showed a definitively enhanced lesion with moderate perifocal edema (Figure  2). A simultaneous F-BPA-PET image showed marked tracer uptake in the right parietal region with a 3.8 L/N ratio of the tracer, indicating that the lesion was a recurrent malignant tumor and not psPD (Figure  2, lower panel).
PMC3923505_03
PMC3923505_04