PMC3350080_01
Concentration-time curve of vancomycin in a 7-year-old child. Initial concentration was collected nine hours after a dose. Shaded area indicates time of active high-flux hemodialysis therapy. Total dialysis time = 6 hours.
CRIM.PEDIATRICS2011-678724.001.jpg
PMC3350080_01_CRIM.PEDIATRICS2011-678724.001.jpg
fig1
Serial vancomycin concentrations were collected during dialysis (Figure 1), and dialysis was stopped after 6 hours when a concentration of less than 50 mcg/mL was achieved. There was a noticeable redistribution effect of vancomycin following cessation of dialysis (Figure 1) with a resulting rise in vancomycin concentration to a second peak of 73.9 mcg/mL 22 hours after stopping dialysis.