PMC9685536_01
(A) Cranial enhanced MRI showing the right parietal lobe mass measuring approximately 2.1 cm (red arrow); (B) linear enhancement of leptomeninges in the left cerebral hemisphere (red box); (C) the right parietal lobe mass shrank 6 months after aumolertinib plus bevacizumab treatment; (D) linear enhancement of leptomeninges disappeared 6 months after aumolertinib plus bevacizumab treatment.
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Figure 1 ). Furthermore, the effect of the combination therapy has lasted for >22 months and is still in close follow-up.
PMC9685536_02
(A) Cranial enhanced MRI showing linear enhancement of leptomeninges in the temporal lobe (red box); (B) linear enhancement of leptomeninges disappeared 2 months after aumolertinib plus bevacizumab treatment.
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A repeated MRI revealed significant parenchymal and leptomeningeal lesion improvements ( Figure 2 ).
PMC9685536_03
(A) Cranial enhanced MRI showing left frontotemporal linear enhancement (red box); (B) linear enhancement of leptomeninges shrunk 2 months after aumolertinib plus bevacizumab treatment.
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Figure 3 ). Furthermore, the efficacy has been durable for 10 months without any notable side effects.
PMC9685536_04
(A) Cranial enhanced MRI showing linear enhancement of ventricular ependyma (red arrow); (B) linear enhancement of leptomeninges regressed 2 months after aumolertinib plus bevacizumab treatment.
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Leptomeningeal dissemination and brain metastases had regressed on MRI 2 months after the treatment initiation ( Figure 4 ).
PMC9685536_05
(A) Cranial enhanced MRI showing patchy high signals in the left temporal lobe (red box); (B) high signals of leptomeninges disappeared 2 months after aumolertinib plus bevacizumab treatment.
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Leptomeningeal metastases showed a complete disappearance after 2 months of treatment ( Figure 5 ).