PMC5048359_01
Findings in case 1 were weight loss, weakness, fasciculation, and the gait of both forelimbs.
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Case 1 was a 15-year-old female (Arupasa) with noticeable physical disorders, including fasciculation and palpation of the withers (Fig. 1, Table 1).
The muscle necrosis with fibrosis in case 1 (arrow).
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Partial muscle necrosis with fibrosis was also seen (Fig. 2).
The histopathological findings with muscle fiber atrophy in case 1 (arrow).
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Histopathological findings included Bunina bodies in nerve cytoplasm of the spinal cord ventral horn and in muscle fibers (Figs. 3, 4, 5).
The histopathological findings with Bunina bodies (arrow) in nerve cytoplasm of the spinal cord (ventral horn) in case 1.
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Histopathological findings included Bunina bodies in nerve cytoplasm of the spinal cord ventral horn and in muscle fibers (Figs. 3, 4, 5).
Swelling of the nerve axons of the spinal cord ventral horn in case 1 (arrow).
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Histopathological findings included Bunina bodies in nerve cytoplasm of the spinal cord ventral horn and in muscle fibers (Figs. 3, 4, 5).
PMC5048359_02
Characteristic gathering of feet under the body ("horse on a ball") in a horse with acutely presenting EMND (case 2). Elevation of the tailhead in the
horse.
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After 59 weeks, the animal started to show fasciculation in both hind limbs, heavy sweating of the whole body, increased heart rate (100 beats min), respiratory distress (30 beaths min), CRT extension (3 sec), eye conjunctival hyperemia, dry mouth, and tension in the hind limbs (Fig. 6).
Neurogenic atrophy in the tongue (arrow) (case 2).
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The results revealed extensive limbs and tongue neurogenic muscle atrophy (Fig. 7).
PMC5048359_03