PMC8378835_01
Obvious signs detected on sight: protruding lower jaw, an enlarged nose, thickened lips, Olympian forehead and protrusive eyebrow arches.
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On examination, there were new obvious signs detected on sight: protruding lower jaw and brow, an enlarged nose, thickened lips, coarse fingers and toes (Fig. 1).
Hypodense liver metastatic nodule (blue arch), lesion in the right side of the third lumbar vertebra reaching the medullary canal (red arch), left pneumonectomy with diffuse right pulmonary dense nodules. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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We spotted multiple osseous lesions concerning the posterior arch of the 12th left rib with extension to the soft parts, the right side of the third lumbar vertebra, and into the medullary canal (Fig. 2).
Malignant epithelial proliferation arranged in cords within a thin fibro-vascular stroma (A). Cells Immunostaining revealed Synaptophysin and Chromogranin (B).
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