PMC4242899_01
The image shows a 17 mm high intensity area in the pons on T2-weighted (A) and diffusion-weighted (B) magnetic resonance imaging (MRI) of the brain.
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Brain magnetic resonance imaging (MRI) revealed a non-enhancing, high-intensity area of 17 mm in diameter in the pons on T2- and diffusion-weighted imaging (Figure 1A and B); however, no abnormal neurological signs were observed.
Pathological specimens.. Notes: (A) Skin biopsy specimen taken from the lower abdomen reveals proliferation of large lymphoma cells filling the vessels of hypodermic adipose tissue. (B) Numerous lymphoma cells with irregular nuclear contours and large nucleoli clustered are seen in small vessel lumens. Hematoxylin and eosin staining; magnification (A) x40 (B) x100.
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All specimens revealed large B lymphoma cells within small veins and capillaries of the subcutaneous fat tissues but not outside the vessels (Figure 2A and B).
Immunohistochemistry demonstrating positivity of intravascular lymphoma cells for CD20.. Note: Magnification x100.
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Magnetic resonance imaging (MRI) of the brain after receiving chemotherapy.. Notes: Pontine lesion on T2-weighted (A) and diffusion-weighted (B) MRI of the brain completely resolved after eight cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.
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After eight cycles of R-CHOP therapy, the pontine lesion had completely disappeared (Figure 4A and B).