PMC5215554_01
Distribution and disease penetrance of ALSP cases with CSF1R mutation. (a) The mean age of onset in women was significantly younger than that of men. (b) Kaplan-Meier curves showing the difference in probability of survival between sexes. There was no significant difference. (c) Kaplan-Meier curves showing the age-dependent penetrance. There was a significant difference between sexes.
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In addition, the age-dependent penetrance plays a role, as shown in Fig. 1c.