PMC9151731_01
A-C) Preoperative chest HR-CT image shows multiple 1-to-8-mm round nodes (white arrowheads). The black arrowheads indicate sporadic pulmonary cysts. These findings were limited to the right lower lobe, but they were not aggregated. D) The maximum intensity projection (MIP) reformation and E) the minimum intensity projection (MinIP) reformation of post operative HR-CT. The white arrowheads indicate residual nodules in the right lower lobe. Mosaic perfusion was not demonstrated.
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Small lung cysts were also observed in the peripheral pulmonary parenchyma of the right lower lobe, suggesting obstructive changes (Fig. 1A-C). The residual peripheral nodules and airway trapping with small lung cysts in the right lower lobe were observed, but no signs of mosaic perfusion were seen (Fig. 1 D, E).
A) Histopathological examination of the resected specimen shows tumors with diameters of 1-5.1 mm and cell proliferation in the bronchioles. B, C) High-magnification image of the tumor shown by the black arrow in A). Prominent spindle cells and fibrovascular stroma can be seen. Immunohistochemistry showed cytoplasmic staining for D) chromogranin A, E) synaptophysin, and F) CD56.
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Pathological examination of the resected specimen revealed multiple nodules composed of spindle cells, and immunohistochemistry revealed staining for chromogranin A, synaptophysin, and CD56, suggesting neuroendocrine tumors (Fig. 2).
Pathological findings of neuroendocrine cell hyperplasia. A) Low-magnification image (black arrow) and B) high-magnification image of an area of neuroendocrine cell hyperplasia. C) CD56 staining showed a linear proliferation of clusters of neuroendocrine cells on the epithelial membrane of bronchioles.
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NECH was also observed on some bronchioles (Fig. 3).