PMC3579744_01
Opaque and ovoid lesion occupying mediant equatorial region of the right.
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F1
Mammography revealed an opaque and ovoid lesion occupying the median equatorial region of the right breast; this lesion was 35 mm in diameter, with regular margins, moderate intensity and homogeneous density; there was no evidence of defined focus of pathological calcification (Figure 1).
a: Breast tissue: invasive neoplasm adjacent to dilacted duct. (Hematoxylin Eosin 20 x). b: Detail of the neoplastic population(Hematoxylin Eosin 40 x).
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F2
a: Three multinuclear giant cells surrounded by neoplastic mononuclear cells (Hematoxylin Eosin 40 x). b: neoplastic cells nuclear features (Hematoxylin Eosin 40 x).
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F3
a: Immunohistochemical staining for Cytokeratin Pan stains the ductal structure while tumor cells are negative(20 x). b: Positivity for Vimentin(40 x).
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F4
Immunohistochemical stainings for Cytokeratin Pan (Figure 4a), Cytokeratin 7-8-18-19, EMA (epithelial membrane antigen), S100 protein, SMA (smooth muscle actin) and CD34 were negative; immunohistochemical staining for vimentin was positive (Figure 4b).