PMC10046802_01
PMC10046802_02
Timing of major events in both kidney transplant recipients. (A) Recipient of the right kidney. (B) Recipient of the left kidney.
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fig1
The timing of most important events for both recipients is presented in Figure 1.
Histopathological findings in the recipient of the right kidney. (A) Adenocarcinoma in the surveillance biopsy of the graft [hematoxylin-eosin (H&E)]. (B) Adenocarcinoma in the surveillance biopsy of the graft - closer view (H&E). (C) Adenocarcinoma in the surveillance biopsy of the graft expressing cytokeratin 7 (immunohistochemical staining). (D) Adenocarcinoma in the surveillance biopsy of the graft expressing mucin-1 protein (immunohistochemical staining).
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Immunohistochemical findings (positive immunohistochemical staining for cytokeratin 19 and 7 and mucin-1 protein) suggested a pancreatic origin of the tumor (Figure 2).
Ultrasound of the growing formation (arrow) in the kidney graft seen in the left kidney transplant recipient. An aspiration needle biopsy showed poorly differentiated cells of metastatic adenocarcinoma.
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In summer and fall 2017, serial ultrasound examinations of the graft showed growing complex formation in the lower pole of the kidney (Figure 3).
Pathological findings in the recipient of the left kidney. (A) Macroscopic view of the adenocarcinoma (arrow). (B) Adenocarcinoma by light microscopy (H&E).
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fig4
Examination of the explanted kidney revealed an adenocarcinoma with identical immunohistochemical features as in the first recipient, suggesting a pancreatic origin of the tumor (Figure 4).