PMC1780055_01
A, C Pre-Operative MRI: contrast-enhancing lesion in the left and right frontal lobe. B MRI follow-up after 6 month: no recurrence of the tumor after resection and irradiation (left frontal). D MRI follow-up after 6 month: no progression of the tumor after irradiation only (right frontal).
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F1
Two intracerebral lesions were identified by magnetic resonance imaging (MRI) of the head (Figure 1A+C). Initial MRI demonstrated a contrast-enhancing lesion in the left frontal lobe and a smaller lesion in the right frontal lobe (Figure 1A+C). MRI identified no tumor recurrence in the left frontal lobe and no progression of the lesion on the right (Figure 1B+D).
Whole-body MRI (T2WI) identified structure of increased signal intensity in close relation to the sciatic nerve (arrow).
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F2
One of the lesions was contiguous with the sciatic nerve (Figure 2 and 3).
Whole-body MRI (T1WI+Gd) axial sacral slice, identified structure of increased signal intensity in close relation to the right sciatic nerve.
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F3
One of the lesions was contiguous with the sciatic nerve (Figure 2 and 3).
Spinal sagittal MRI (T1WI+Gd) identified tumors in the sacral section of spinal column (S1 and S2).
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F4
Spinal MRI demonstrated further metastases at the level of S1 and S2 but no relationship to spinal nerves (Figure 4).
A Hematoxylin-Eosin (H&E) staining, with polymorphic, spindled cells in nestlike clusters (10x). B Melanin within epitheloid cells (20x). C Positive immunreaction against S-100 (20x). D Positive immunreaction against VIM (20x).
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F5
Hematoxylin-eosin (H&E) staining demonstrated tumor tissue with spindled epithelioid cells, some of which contained melanin (Figure 5A+B). Immunohistochemically, strong expression of vimentin (dilution 1:600; Zymed, Wien/Austria) and S-100 (dilution 1:6000; DAKO, Glostrup/Denmark) was demonstrated (Figure 5C+D).