PMC6570645_01
Histology. a Representative portal tract from the liver biopsy with absence of the interlobular bile duct. The hepatocytes show severe small droplet steatosis. (H&E, x400). b The explant liver showed a biliary pattern of cirrhosis with extensive ductular reaction (H&E, x40). c A portal tract from the liver explant with absence of the interlobular bile duct and associated ductular reaction and cholestasis (H&E, x20). d Example of normal portal tract
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Fig1
Representative images are shown in Fig. 1, along with a normal liver biopsy for comparison. Overall the findings were of cholestasis with duct damage, and duct loss (only three of eight portal tracts containing ducts) (Fig. 1a). Overall, the findings were consistent with ductopenia, likely secondary to drug-induced vanishing bile duct syndrome (Fig. 1b, c).
Trends in hepatic enzyme and bilirubin levels in U/L from baseline through 6 months post-liver transplant. Aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) trends are shown on the primary y axis on the left. The total bilirubin (TBili) trends are shown on the secondary y axis on the right
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Fig2
The trend in her LFTs pre- and post transplant are outlined in Fig. 2.