PMC9935475_01
Clinical findings of pemphigus vulgaris after SARS-CoV-2; (a) multiple painful erosive and crusted patches on the scalp and (b) biopsy site from the abdomen.. SARS-COV-2: Severe Acute Respiratory Syndrome Coronavirus 2
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FIG1
An otherwise healthy 17-year-old female presented with a six-week history of multiple erosions on the scalp, nose, abdomen, and mucosal area, including the oral and vulva areas (Figure 1).
(a) Immunohistochemical study of the SARS-CoV-2 spike protein showing positivity in basal keratinocytes (arrows) and endothelial cells (arrowhead) (original magnification x 400). (b) A representative figure of negative staining of a pemphigus vulgaris specimen before 2019 (original magnification x 400).. SARS-CoV-2: Severe Acute Respiratory Syndrome Coronavirus-2
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FIG2
The findings showed fine-to-coarse, bright red granular deposits in the nucleus and cytoplasm of the basal keratinocytes as well as in the vascular endothelial cells and epithelial cells of the eccrine glands (Figure 2a). Negative control in the form of three PV specimens before 2019, biopsies from non-COVID-19 related inflammatory dermatoses revealed no staining (Figure 2b).