PMC7232727_01
Magnetic resonance imaging (MRI). The sella was expanded by a macroadenoma (white arrow) with mild contrast enhancement.
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Magnetic resonance imaging showed that the sella turcica was expanded by a pituitary macroadenoma measuring 2.1 x 1.8 x 1.9 cm (Figure 1).
The tumor has two areas. One dominated by round monotonous cells (double arrows) forming pseudopapillary structures and another (upper area) showing neuropil tissue where scattered neurons (single arrow) are noted (H&E stain, X100).
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Histopathological examination of the resected tumor samples showed two patterns (Figure 2).
(a) Synaptophysin immunohistochemical stain highlights the cytoplasm of the tumor cells (x200). (b) Growth hormone immunohistochemical stain highlighting most of the tumor cells (x200). (c) Small neurons and their axons (arrow) showing strong reactivity to prolactin immunohistochemical stain (x200). (d) Cytokeratin paranuclear dot-like staining depicts fibrous bodies in most of the tumor cells cytoplasm (x200).
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Immunohistochemical studies (Figure 3) showed that the tumor cells are strongly positive for synaptophysin and growth hormone.