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Metastasis of high-grade infiltrating urothelial carcinoma: poorly differentiated carcinomatous process (A), CK7+ (B) and CK20+ (C).
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Thus, the diagnosis retained was that of localization in the breast of a poorly differentiated carcinomatous process compatible with the vesical origin already known in the patient (Fig. 1).
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(A) and (B): Breast metastasis of clear cell carcinoma. Breast tissue infiltrated by a carcinomatous proliferation composed of nests, separated by a vascular network. Tumor cells show clear cytoplasm surrounded by distinct cell membranes.
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The tumor nests are separated by a delicate vascular network (Fig. 2).
Immunohistochemical staining showing positive expression of PAX8 in tumor cells: (A) negative expression of GATA3 (B), RE (C), RP (D).
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Immunohistochemical staining shows PAX 8 antibody and CD10 antibody-positive staining for tumor cells, but negative for GATA3 and CK7 (Fig. 3).
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Immunohistochemical staining showing positive expression of H-caldesmon (A) and Desmin (B) negative expression of CKAE1/AE3 (C).
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The immunohistochemical study confirms the muscular origin by showing the positivity of the myogenic markers (SMA, Desmin, H-caldesmon) (Fig. 5).