PMC8963484_01
Chest X-ray of the lungs from the acute phage of the two fatal cases. (A) Case 1. Acute phage of pneumonia revealed the texture of the two lungs as thickened and fuzzy, the light transmittance of the left lung is diffusely reduced, left diaphragm blurred, the light transmittance of the right lung unevenly reduced, patchy shadows shown in the right lung. (B) Case 2. The lung light transmittance was unevenly reduced, and multiple high-density shadows and small air bubble emphysema were seen in both lungs. Part of the bronchiectasis and part of the cavity were irregular, especially in the middle lobe of the right lung.
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Chest CT demonstrated diffuse parenchymal changes and small alveolar emphysema in both lungs ( Figure 1B ).
Phylogenetic tree based on the two WUPyV complete genome sequences from fatal cases. Phylogenetic analyses were performed with other 114 WUPyV complete sequences submitted to GenBank, with all sequences derived from China (67 in total) and representative sequences from other countries (23 from Australia, 2 from Thailand, 5 from Germany, 3 from Netherlands, 5 from Canada, 3 from Sweden, 3 from South Korea, and 1 from the USA). MEGA v7.0 software was used to generate phylogenetic trees with the neighbor-joining method and the Kimura 2-parameter model. The robustness of the phylogenetic trees was assessed using the bootstrap method with 1,000 replicates. Reference genomes with bootstrap values below 70 are not shown. The strains in the current study are marked with a solid red circle.
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KX034823.1), which was collected from Chongqing, China, in 2013 ( Figure 2 ).