PMC7102415_01
Patient 1: (a) pretreatment; (b) after 4 weeks treatment with tretinoin and azelaic acid; and (c) after 12 weeks treatment with tretinoin lotion and azelaic acid.
CRIDM2020-5217567.001.jpg
PMC7102415_01_CRIDM2020-5217567.001.jpg
fig1
Hyperpigmented macules were noted on her chest and back, along with hyperpigmented papules and pustules on her back (Figure 1(a)). The patient denied any itching or burning sensations where the tretinoin 0.05% lotion had been applied, and there was no evidence of retinoid dermatitis or xerosis in the treatment areas. (Figure 1(b)).
PMC7102415_02
PMC7102415_03
Patient 3: (a) pretreatment (chin and neck); (b) pretreatment (chest); (c) pretreatment (back); (d) after 12 weeks treatment with tretinoin lotion and azelaic acid (chin and neck); (e) after 12 weeks treatment with tretinoin lotion and azelaic acid (chest); and (f) after 12 weeks treatment with tretinoin lotion and azelaic acid (back).
CRIDM2020-5217567.002.jpg
PMC7102415_03_CRIDM2020-5217567.002.jpg
fig2
The patient's chest had erythematous papules and macules, while her back and shoulders had many erythematous papules and hyperpigmented macules (Figures 2(a)-2(c)).
PMC7102415_04