PMC8407784_01
MRI coronal view showed a mass in the nasal cavity (A) and MRI sagittal view showed a heterogeneously enhanced mass (red arrow) at nasal cavity affecting ethmoid sinus, sphenoid sinus and hard palate bone (B).
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Magnetic resonance imaging (MRI) revealed a mass measuring 20 mm in the nasal cavity, affecting the ethmoid sinus, sphenoid sinus, and hard palate bone (Figure 1).
Histomorphological details of NC. Tumor was composed of basaloid squamous cells. The periphery of the tumor nests was arranged in a palisade pattern. Focal abrupt keratinization could be seen (A x100; B x400).
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Abundant cytoplasm, frequent mitotic figures, and focal abrupt keratinization with few keratin pearls were evident (Figure 2).
Immunohistochemistry staining of tumor cells that were positive for CK (A x200), p40 (B x200) and NUT (D x40; inset x400). Ki-67 index of tumor cells was >60% (C x200).
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The Ki-67 index was >60% (Figure 3). Shundong Dai, Department of Pathology, Shanghai Ninth People's Hospital), and the diffuse strong staining of NUT was consistent with the FISH data (Figure 3D).
Fluorescence in situ hybridization demonstrated the gene rearrangement of NUTM1. Large proportion cells showing 1 red 1 green 1 fusion signal, indicating NUTM1 fused with partner genes.
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Finally, the patient requested a FISH test in our hospital, which demonstrated that the proportion of 1 red 1 green 1 fusion signal was 23%, the proportion of 1 red 1 green signal was 10%, and that of 1 red 1 fusion signal was 5% (Figure 4).