PMC9684727_01
Two CT images of the chest on admission and after treatment. (A-C) A cavernous and fluid-flat mass in the lower lobe of the left lung and multiple nodules in the upper lobe of both lungs (the largest nodule is shown in the figure), both of which show mild circumferential enhancement on enhancement scans. (A) Unenhanced period. (B) Venous phase. (C) Pulmonary window. (D) Postoperative changes in the left lung, with significantly smaller nodules in the upper lobes of both lungs (largest nodule in the figure) than before.
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Chest CT examination was performed on May 16, 2021 ( Figures 1A-C ). A CHOP chemotherapy regimen (ECOG score 0 points, body surface area 1.52 m2, cyclophosphamide 1.1 g1day, pyridoxine 70 mg1day, vinorelbine 40 mg1day, prednisone 100 mg1-5day) was given on August 23, September 16, October 7, October 27, November 18, December 7, 2021, at the Department of Hematology of our hospital, and the CT scan was repeated on October 27, showing that the patient's condition improved ( Figure 1D ).
Microscopic findings and immunohistochemistry of surgical pathological specimens: lymphoid cells infiltrated the blood vessel wall in tumor tissue, B lymphocytes scattered in the background of abundant T lymphocytes, and T lymphocytes heteroplasia, with CD8-positive cells as the host. (A, B) Hematoxylin-eosin staining (x100 and x400). (C, D) Immunohistochemical results of CD4 (x100 and x400). (E, F) Immunohistochemical results of CD8 (x100 and x400).
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The macroscopic examination of the surgical specimen from June 19, 2021 ( Figure 2 ) revealed a 4x1.4x1 cm piece of lung tissue in the left upper lung and a 0.8x0.8x0.7 cm tumor seen in the lung tissue at a distance of 0.6 cm from the lung resection margin.