PMC6333084_01
PMC6333084_02
A, TLR4 promoter consensus DNA sequences and SNPs in the present case at the indicated positions. Closed arrow indicates the rare homozygote revealed by direct sequencing at -3612. B, Schema of periodic fever induction that is possibly affected by TLR4 polymorphisms and menstruation through bacteria colonization in the present case. Abbreviation: LPS, lipopolysaccharide
CCR3-7-155-g001.jpg
PMC6333084_02_CCR3-7-155-g001.jpg
ccr31941-fig-0001
On the other hand, the TLR4 promoter region included six of the eight SNPs that had been found in Swedish patients with ABU (Figure 1A).