PMC4378881_01
Histologic features of the tumor: (a) HE Staining x 40: modular malignant epithelial proliferation overlayed by hyperplastic epidermis with paget's lesion. (b): HE Staining x 40: trabecular proliferation centrated by necrotic areas. (c): HE Staining x 400: Cuboid epithelial cells with indistinct borders amphophilic cytoplasm and hyperchromatic nuclei. Figures of mitoses are frequent. (d): positive immunostain of this tumor cells by the anti cytokeratine 7. (e): Diffuse and intensive immunostain of the tumor cells by the anti Her-2/neu
PAMJ-19-188-g001.jpg
PMC4378881_01_PAMJ-19-188-g001.jpg
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Some mitotic figures are seen (Figure 1: a, b, c). Immunohistochemical study showed that the tumor cells were positive for low-weight cytokeratin (CK7), EMA and Her-2/neu (Figure 1: d, e).