PMC10199318_01
Physical features and MRI of the brain of the girl. (a) Simian crease was found in the right palm; (b) comparison of the foot size between the patient (R) and healthy counterpart (L); (c) comparison of the palm size between the patient (L) and healthy counterpart (R); (d) I  cleft palate; (e) MRI findings of hydrocephalus; (f) comparison of physical characteristics between the patient (R) and healthy counterpart (L).
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Upon admission, the child was conscious and in normal mental status, malnourished, emaciated (weighed 4.7 kg), body height of 63 cm, pale skin, simian crease was found in the right palm, small-size limbs (Figure 1a-c), small head circumference (36.5 cm), anterior fontanelle closure, normal eye movement, occasional tremor, and no strabismus. A 1 cm long cleft was seen in the upper jaw (Figure 1d).