PMC8024097_01
MRI-Scan showing a suspicious lesion of the remaining left testis (a). Cross-section of the specimen showing a biphasic lesion (b). A microscopic overview showing paratesticular tissue at the top, ovarian tissue on the left side, and an eosinophilic tumor on the right side (c).
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Macroscopically, a biphasic mass was observed (Figure 1(b)). Histologically, the main tumor mass showed a solid growth pattern (Figure 1(c)) with eosinophilic granules and occasional Reinke crystalloids (Figure 2(a)).
Leydig cell tumor with characteristic Reinke crystalloids (a), positivity for calretinin (b), inhibin (c), and melanA (d). Compressed seminiferous tubules in the Leydig cell tumor (e). Ovarian tissue with corpora albicantia (f).
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Histologically, the main tumor mass showed a solid growth pattern (Figure 1(c)) with eosinophilic granules and occasional Reinke crystalloids (Figure 2(a)). Immunohistochemic positivity for inhibin, calretinin, and melanA confirmed the diagnosis of a Leydig cell tumor (Figures 2(b)-2(d)). A few remaining compressed seminiferous tubules without remaining spermatogonia were embedded in the tumor (Figure 2(e)). The second mass showed ovarian stroma with several corpora albicantia, but without any oocytes or follicles, resulting in the initial diagnosis of a DSD, ovotesticular (Figure 2(f)).