PMC9215171_01
MRI of the patient years after surgery removal of the astrocytoma. An area of right frontoparietal encephalomalacia is observed with retraction of the frontal horn of the right lateral ventricle with slight perilesional edema.
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A brain MRI showed gliosis in the left temporal region suggestive of metastasis without further investigation ( Figure 1 ). Additional findings included a left spinal nodule with a lipomatous appearance and uterine fibroids ( Supplementary Figure 1 ).
Structural conformation and pairing of ACSL6. (A) Weight isoform with secondary structure coloring. On the light green alpha-helices, on the purple beta-sheet and the coils. (B) Structural alignment of both models. In both arrows they represent the point where the amino acid change occurs. (C) Differences representing 21.5%. dissimilarity. At the bottom, the transmembrane domain. In gray structural agreements between models.
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Modifications at this level alter how enzymes:like ACSL6:carry out their catalysis, how atoms bind to cofactors, and how substrates interact with the binding pocket ( Figure 2 ) ( Supplementary Figure 2 ).