PMC9582333_01
(A) Light microscopy shows glomerular sclerosis, fibrous crescents, interstitial fibrosis, and tubular atrophy (H&E, 100X). (B) Glomerulus with fibrocellular crescents (H&E, 400X). (C) Active glomerular lesion showing endo and extracapillary hypercellularity (H&E, 400X). (D) Thickened and tortuous arteriole associated with globally sclerotic glomerulus and extensive parenchymal atrophy and fibrosis (H&E, 400X).
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F1
A kidney biopsy was performed 15 days after initiation of treatment and 80 days after vaccine administration (Figure 1) and revealed crescentic glomerulonephritis with glomerular sclerosis, fibrous crescents, interstitial fibrosis, and tubular atrophy (Figures 1A,B). We also observed in the glomeruli active inflammatory lesions characterized by endothelial swelling, endocapillary proliferation, accumulation of macrophages, hyaline deposits and cellular e fibrocellular crescents (Figures 1B-D).