PMC2831908_01
Computed tomography scan showing splenic masses.
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F1
A computed tomography (CT) scan of her abdomen was ordered by her primary care physician, and this showed multiple masses within the spleen which were suspicious for malignancy (Figure 1).
Sections of spleen showing intraparenchymal masses.
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F2
Pathologic examination of the gross specimen (Figure 2) revealed intraparenchymal splenic lesions.
Representative section of ovary stained with hematoxylin and eosin (100x) demonstrating irregular nests of large anaplastic cells with an ill-defined cribriform architecture infiltrating the ovary. No residual normal ovarian tissue is shown.
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F3
Representative sections from the ovary (Figure 3) and spleen (Figure 4) are shown here. The tumor at both sites showed a similar morphology of a poorly differentiated adenocarcinoma consisting of irregular nests of large anaplastic polygonal cells with an ill-defined cribriform pattern (Figure 3, inset).
Representative section of spleen stained with hematoxylin and eosin (20x) demonstrating morphology similar to that seen in the ovary. Normal residual spleen is seen on the right.
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F4
Representative sections from the ovary (Figure 3) and spleen (Figure 4) are shown here.