PMC3919839_01
Lymph node showing evident loss of architecture with widespread apoptosis and necrosis (inset, at high power). [Copyright:  2014 Di Lernia et al.]
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The lymph node structure was completely effaced by diffuse necrotic areas with abundant karyorrhectic debris (Figure 1); the search for DNA of Mycobacterium tuberculosis was negative.
At low power, the epidermis is hyperkeratotic and the basal membrane is focally thickened. The dermis shows scattered aggregates of granulocytes (A). Interstitial mucin deposits are highlighted with Alcian PAS stain (B). [Copyright:  2014 Di Lernia et al.]
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The dermis showed conspicuous interstitial mucin deposits, dense perivascular and perifollicular lymphocytic infiltrates with interface dermatitis (Figure 2) and superficial nuclear debris with karyorrhexis.