PMC3764967_01
Abdominal CT images. a Before ERT. Liver size: 23.3 x 15.4 x 20.3 cm. Spleen size: 12.8 x 10.5 x 21.1 cm. b 5 months after ERT started. Liver size: 22.1 x 15.3 x 17.9 cm. Spleen size: 11.8 x 9.4 x 17.3 cm.
crg-0007-0340-g01.jpg
PMC3764967_01_crg-0007-0340-g01.jpg
F1
The splenic and the superior mesenteric vein were dilated and tortuous, whereas no apparent cirrhotic change of the liver was observed (fig. 1a). Figure 1b shows the CT scan 5 months after ERT started.
Microscopic findings of liver biopsy specimen. a, b Gaucher cells in Glisson's capsule (Elastica-Masson, a x40, b x400). c Arrowheads indicate the assembly of Gaucher cells in Glisson's capsule (hematoxylin and eosin, x200). d The cytoplasm of Gaucher cells is well stained with periodic acid-Schiff (x400).
crg-0007-0340-g02.jpg
PMC3764967_01_crg-0007-0340-g02.jpg
F2
The liver biopsy specimen showed that numerous large cells with striated cytoplasm assembled in Glisson's capsule (fig. 2).
Changes in platelets count and ACE concentration during the course of ERT.
crg-0007-0340-g03.jpg
PMC3764967_01_crg-0007-0340-g03.jpg
F3
Platelet counts number and ACE concentration, a biomarker of the progress of Gaucher disease, were also improved from 7.4 to 11.3 x 104/mul and from 42.5 to 24.7 IU/mul, respectively (fig. 3).