PMC7608632_01
The timeline of the case report.
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The overall timeline is summarized in Figure 1.
Positive DFX challenge: a few discrete ill-defined erythematous macules on the right arm.
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Generalized pruritic papular rash (Ring and Messmer grade 1) occurred at the cumulative dose of 611 mg (Figure 2).
Lip angioedema during the second DFX graded challenge and treating through with H1-antihistamine.
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She developed mild lip angioedema 45 minutes after the last dose (Figure 3), which spontaneously resolved the next day without increasing the dose of antihistamine.