PMC5345969_01
Clinical course of the patient. Top: Treatments and interventions. H, isoniazid; R, rifampicin; E, ethambutol; Z, pyrazinamide; L, levofloxacin; PSL, prednisolone; NAd, noradrenaline; NHF, nasal high flow; NIPPV, non-invasive positive pressure ventilation; IPPV, invasive positive pressure ventilation. Middle: Serum level of TNFalpha and whole-blood level of IFNgamma. IFNgamma-release assays were performed with the T-SPOT. TB and QuantiFERON TB Gold-In-Tube kits. T-SPOT panel A, the number of ESAT-6-specific spot-forming cells; T-SPOT panel B, the number of CFP-10-specific spot-forming cells. QFT TB, amount of IFNgamma produced in response to TB antigen; QFT Mitogen, amount of IFNgamma produced in response to stimulator; QFT Nil, non-specific baseline IFNgamma level. Bottom: High-resolution computed tomography of the thorax on days 0, 25, and 37, showing progressive worsening of disseminated TB, followed by fibrosis.
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fig1
TB (Fig. 1). The presence of Mycobacterium tuberculosis was confirmed by polymerase chain reaction on gastric lavage obtained on admission to the previous hospital (day -1).