PMC10118668_01
Biopsy of the right gonad showing germ cells intermingled with seminiferous tubules with decreased diameter.
2359-4292-aem-62-06-0644-gf01.jpg
PMC10118668_01_2359-4292-aem-62-06-0644-gf01.jpg
f1
The histology revealed bilateral dysgenetic testes with signs of neoplastic transformation on the right gonad (Figure 1).
Large clear germ cells with prominent nuclei interspersed by other small cells with hyperchromatic nuclei and scant cytoplasm (immature Sertoli cells).
2359-4292-aem-62-06-0644-gf02.jpg
PMC10118668_01_2359-4292-aem-62-06-0644-gf02.jpg
f2
The right gonad had two neoplastic lesions: a premalignant one (germ cell cluster, clonal proliferation), within a region of undifferentiated gonadal tissue, and a gonadoblastoma (Figures 2 and 3).
Germ cells positive for OCT3/4.
2359-4292-aem-62-06-0644-gf03.jpg
PMC10118668_01_2359-4292-aem-62-06-0644-gf03.jpg
f3
The right gonad had two neoplastic lesions: a premalignant one (germ cell cluster, clonal proliferation), within a region of undifferentiated gonadal tissue, and a gonadoblastoma (Figures 2 and 3).
PMC10118668_02