PMC7218518_01
Cerebral blood flow imaged by SPECT during mania and after recovery. a During mania, the blood flow in the orbitofrontal cortex (OFC) was low (solid-line circle), while the blood flow in the posterior cingulate cortex (PCC) was high (dashed circle). b After recovery, blood flow was normalized in both the OFC and the PCC
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Fig1
Magnetic resonance imaging was not available due to his tattooed back, but single photon emission computed tomography (SPECT) revealed low blood flow in the OFC and high blood flow in the PCC (Fig. 1a). Hypo-activity in the OFC and hyper-activity in the PCC were no longer detected by SPECT (Fig. 1b).