PMC4365557_01
Contrast-enhanced CT scan performed at the time of diagnosis in December 2009. (a) Presence of a large mass arising from an osteochondroma (arrow) of the left iliac bone (coronal plane, bone window, venous phase); (b) the primary tumour appears as a poli-lobulated mass extending within the pelvis, characterised by an irregular, peripheral contrast enhancement and scattered calcification islets (circle) (axial plane, abdomen window, arterial phase).
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Fig1
December 2009, a 38-year old woman, in good general conditions, was diagnosed a 17-cm large mass arising from an osteochondroma of the left iliac bone (Figure 1). Diagnostic biopsy revealed grade 2 secondary peripheral cCS (Figure 2).
Tru-cut biopsy of the pelvic, primary tumour, performed in December 2009. Histopathological examination (HE x5, inset x10): fibrous tissue with nests of cartilaginous proliferation with hypercellularity and variation in cellular size and shape, in a focally myxoid matrix. Final diagnosis was G2 peripheral conventional chondrosarcoma. Radiologic features were not consistent with the presence of dedifferentiated areas thus supporting the final diagnosis of a conventional chondrosarcoma.
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Fig2
December 2009, a 38-year old woman, in good general conditions, was diagnosed a 17-cm large mass arising from an osteochondroma of the left iliac bone (Figure 1). Diagnostic biopsy revealed grade 2 secondary peripheral cCS (Figure 2).
CT scan without contrast of the liver at the time of the first hepatic progression, showing a single metastasis, characterised by pronounced hypodensity and calcification islets (axial plane, abdomen window).
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Fig3
In July 2012, the disease progressed locally and gave a single liver metastasis, confirmed on biopsy (Figure 3).
Contrast-enhanced CT scan of the liver and the pelvis (axial plane, abdomen window, venous phase). The progressive hepatic metastasis (black arrow) before (a) and after (b) chemotherapy with cisplatin/etoposide, then a RECIST response after 4 (c) and 9 (d) cycles of gemcitabine. Pelvis reports (e-h) appear stable (white arrow: primary tumour; asterisk: urinary bladder).
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Fig4
By RECIST the disease looked stable with regard to the pelvic, primary lesion, while a partial response of the liver lesion was observed (Figure 4).