PMC9932956_01
Morphological appearances of KAT6A::NRG1 fusion Renal cell carcinoma. (A) On H&E, the tumour had heterogenous morphology with areas had tubular architecture and resembled type 2 papillary renal cell carcinoma (top) while others had papillary areas with subnuclear vacuolation and more solid nests (inset). B-E are represetative of the immunohistochemical profile. Whereas some markers such as RACEMASE (B) and PAX8 (C) were diffusely expressed in all areas (cytoplasmic and nuclear resectively), CK7 (D) was almost exclusively expressed in the tubular areas while Melan A (E ) was more strongly expressed in the solid areas. Interestingly, the morphology of the lymph node metastatic deposits (F) resembled clear cell papillary renal cell carcinoma. {Magnification x200 (A) and x100 (B-F).
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In addition, there was heterogenous expression of CK7, AMACR and Melan A ( Figure 1 ). The immunohistochemical profile was identical to the core biopsy results ( Figure 1 ). The lymph node metastasis resembled the morphological appearance of clear cell papillary renal cell carcinoma ( Figure 1F ).