PMC10015970_01
Clinical photographs of patient 1 before and after baricitinib treatment. Multiple, depigmented patches on the trunk. (a-c) Significant repigmentation on the trunk after twice-daily oral baricitinib application for 8 months. (d-f).
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A halo nevi was also found on the right ribs (Figure 1a-c). Notably, 8 months after treatment initiation, the hypopigmented patches showed significant repigmentation with good tolerance (Figure 1d-f).
PMC10015970_02
Clinical photographs of patient 2 before and after baricitinib treatment. Multiple, hypopigmented-to-depigmented patches on the trunk and extremities. (a-c) Significant repigmentation on the trunk and extremities after twice-daily oral baricitinib application for 6 months. (d-f).
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Physical examination showed multiple, hypopigmented-to-depigmented patches of skin on the facial area, trunk, and extremities (about 60% BSA, basic surface area) (Figure 2a-c). Over 75% repigmentation of the lesions was observed after 6 months (Figure 2d-f).