PMC4802571_01
Scleroderma digital ulcers. Ulcers on the (A) volar left third digit and (B) the lateral right second digit occurring within weeks of discontinuation of divalproex sodium. Re-epithelialization of the ulcers (C and D) after 2 months of therapy.
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Within weeks of discontinuing divalproex sodium the patient developed 4 painful digital ulcers (Fig 1, A and B). Divalproex sodium ER 250 mg daily was restarted, and the ulcers healed (Fig 1, C and D).