PMC6302154_01
High-resolution computed tomography findings. (A, B) Chest computed tomography showed emphysema in the upper lung and wide-ranging ground-glass attenuation and reticulation with lower-lobe predominance. Ground-glass attenuation was distributed mainly in the peripheral areas and partially along the bronchovascular bundles. (C, D) At 3 months following the diagnosis of DIP, immunosuppressive treatment with prednisolone had led to an improvement in the radiological findings.
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The ground-glass attenuation was distributed mainly in peripheral areas and partially along the bronchovascular bundles (Fig. 1A and B). Moreover, findings from HRCT performed 3 month later confirmed this improvement (Fig. 1C and D).
Histological findings of the lung. (A) The alveolar architecture was relatively maintained, although chronic inflammatory infiltrate was present within the interstitium. Interstitial fibrosis was mild. The severity of the lesions varied from one lobe to another (Hematoxylin and eosin [HE] staining, x 12.5). (B) Many lymphoid follicles were observed in interstitial and peribronchial areas (HE staining, x 12.5). (C) This lesion was characterized by an accumulation of large macrophages in the alveolar space with inflammatory cell infiltration in the alveolar septa, pleura, and interlobular septa (HE staining, x 100). (D) This lesion showed an accumulation of pigmented eosinophilic macrophages in the alveolar spaces with infiltrating plasma cells and lymphocytes (HE staining, x 200).
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Histologically, the lesion was well defined, mainly by the interlobular septum, and showed an accumulation of large eosinophilic macrophages in the alveolar space with inflammatory cell infiltration in the alveolar septa, pleura, and interlobular septa (Fig. 2A-D). Many lymphoid follicles were observed in the interstitial and peribronchial areas (Fig. 2B).