PMC6020482_01
The appearance of skin lesions on the lower extremity of the patient. Note the linear pattern of the skin lesions.
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fig1
Based on the linear pattern of skin vesicular lesions, the diagnosis of IP was raised in consultation with a dermatologist (Figures 1-3).
The appearance of skin lesions on the trunk and upper extremity of the patient.
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fig2
Based on the linear pattern of skin vesicular lesions, the diagnosis of IP was raised in consultation with a dermatologist (Figures 1-3).
The appearance of skin lesions on the arm of the patient.
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fig3
Based on the linear pattern of skin vesicular lesions, the diagnosis of IP was raised in consultation with a dermatologist (Figures 1-3).
An ulcerative lesion with a fibrinous cap and intraepidermal vesicles (H&E x40).
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fig4
Skin punch biopsy revealed an ulcerative lesion with a fibrinous cap and spongiotic vesicles (Figure 4) with marked eosinophilic exocytosis associated with dyskeratotic keratinocytes and eosinophilic intraepidermal microabscess formation (Figure 5).
Dyskeratosis with prominent eosinophilic spongiosis and microabscess formation (H&E x400).
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fig5
Skin punch biopsy revealed an ulcerative lesion with a fibrinous cap and spongiotic vesicles (Figure 4) with marked eosinophilic exocytosis associated with dyskeratotic keratinocytes and eosinophilic intraepidermal microabscess formation (Figure 5).
Disappearance of skin lesions in 11-month old.
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fig6
In the repeated patient's follow-up until the age of 11 months, eye and CNS evaluations were unremarkable; also skin lesions have been completely improved (Figure 6).