PMC8317776_01
Hematoxylin and eosin staining showing (A) carcinomatous focus composed of fused irregular glands with cribriform and central necrosis; (B) sarcomatous areas with spindle and pleomorphic cells and atypical mitosis; and (C) carcinoma with an adjacent sarcomatous area with patchy necrosis.
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Areas of the tumor also had spindle and pleomorphic cells with enlarged hyperchromatic nuclei intermixed with the carcinomatous component (Fig. 1).
Immunohistochemical staining showing pan-cytokeratin positivity in carcinomatous and sarcomatous cells.
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Immunohistochemistry revealed positivity for pan-cytokeratin and vimentin in the sarcomatous foci, and positivity for pan-cytokeratin, high-molecular-weight keratin, and NKX3.1 in the carcinomatous areas (Fig. 2, Fig. 3).