PMC9207503_01
Kidney biopsy findings: (A) Global glomerular basement membrane thickening (Masson's Trichrome, 400x). (B) Glomerular characteristic deposits forming "spikes" and "chain links" figures (periodic acid methenamine, 1,000x). (C) PLA2R immunohistochemical stain revealing no immunoreactivity (400x). (D) Some glomeruli show weak and segmental staining for thyroglobulin along the glomerular capillary (200x).
fimmu-13-824124-g001.jpg
PMC9207503_01_fimmu-13-824124-g001.jpg
f1
Light microscopy revealed a diffuse GBM thickening (Figure 1A) with characteristic deposits ("spikes" and "chain links") under silver stain (Figure 1B) and a mild mesangial matrix expansion and focal segmental mesangial proliferation. IgG (3+/3+), in granular pattern, and global and diffuse distribution along the GBM, in addition to 2+/3+ staining for IgA, IgM, C3, C1q, Kappa resembling IgG, in a "full house" pattern. Immunohistochemical staining for PLA2R was negative (Figure 1C) for thyroglobulin (TG) (Figure 1D), showing weak and segmental staining along the glomerular capillary, and anti-thyroid peroxidase (TPO) antibody was not available.