PMC5604556_01
CT scan before and after apatinib/TMZ treatment (the lesions are indicated by red triangles): multiple metastases can be found in lungs and liver before apatinib/TMZ therapy (A and B), and the lesions were smaller in lungs (C and E) after 2 months' administration of apatinib/TMZ and could barely be seen in liver (D and F) after 5 months of apatinib/TMZ treatment.. Abbreviations: CT, computed tomography; TMZ, temozolomide.
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The results showed multiple metastases in both lungs, hilar lymph nodes, liver, and bones (including vertebra, sternum, and iliac bone; Figure 1A and B), and it was considered to be a progressive disease (PD). After 2 months of treatment, the lesions in lung and liver were significantly reduced in size, which was considered to be a partial response (PR) based on the CT scan (Figure 1C and D). The following reviews of CT and MRI 3 months later showed no progression (Figure 1E and F).
Immunohistochemical staining showing high expression of CD117 and VEGFR-3. Magnification power: 100x.. Abbreviation: VEGFR-3, vascular endothelial growth factor receptor 3.
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The protein expressions of CD117 and VEGFR3 were high (Figure 2).