PMC3420691_01
Highly atypical spindle cells arranged in fascicles, and presenting brisk mitotic activity (H&E, x400).
CRIM.PATHOLOGY2012-579245.001.jpg
PMC3420691_01_CRIM.PATHOLOGY2012-579245.001.jpg
fig1
Paraffin sections showed a tumor composed of spindle cells, arranged in interlacing fascicles (Figure 1).
A remaining breast duct in the periphery of the tumor, immunoreactive to keratins AE1/AE3, surrounded by compactly arranged malignant cells, negative to keratins (DAB/Hematoxylin, x400).
CRIM.PATHOLOGY2012-579245.002.jpg
PMC3420691_01_CRIM.PATHOLOGY2012-579245.002.jpg
fig2
Malignant cells were infiltrating between pre-existing benign ducts in the periphery of the tumor (Figure 2).
Many cancer cells are moderately to strongly positive to CD68 (DAB/Hematoxylin, x400).
CRIM.PATHOLOGY2012-579245.003.jpg
PMC3420691_01_CRIM.PATHOLOGY2012-579245.003.jpg
fig3
All of the above antibodies presented a negative reaction in the tumor cells, except CD68 (Figure 3) and vimentin.