PMC5099173_01
Measurements of systemic and hemodynamic variables during ECMO "weaning." From top to bottom HR, MABP, SaO2, EtCO2, ECMO Flow, and cTOI, pTOI. These data was collected in a 3-years old infant.
fphys-07-00515-g0005.jpg
PMC5099173_01_fphys-07-00515-g0005.jpg
F5
Figure 5 displays some of the raw measurements taken during ECMO weaning. The upper plots in Figure 5 shows the changes in HR, MABP, SaO2, EtCO2, and the ECMO Flow.
On the left partial linear contributions of the systemic variables on the cTOI, gray solid line, and pTOI, black solid line, estimated using SIDE-ObSP. From top to bottom, partial contribution from HR, MABP, SaO2, EtCO2, and ECMO flow. On the right the frequency response of the individual subsystems linking each input with the output. This response was computed as the amplitude of the Fourier transform of the estimated impulse responses obtained from SIDE-ObSP. The frequency responses are organized presenting the one related to the cerebral hemodynamics first followed by the one related to the peripheral hemodynamics, for each input variable.
fphys-07-00515-g0006.jpg
PMC5099173_01_fphys-07-00515-g0006.jpg
F6
The results are presented in Figure 6. Taking this information into account the results presented in Figure 6 indicate that, in contrast with the peripheral circulation, the changes in cerebral hemodynamics caused by variations in MABP, HR, and ECMO flow are highly attenuated since the gain values are much smaller in the frequency response that correspond to the cerebral hemodynamics than the one from the peripheral hemodynamics.