PMC10434558_01
Flow cytometry images of the B cell phenotyping: the reduced levels of total and switched B memory cells and plasmablasts are clearly visible.
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Table 1 ;  Figure 1 ), in particular, a decrease in both the percentage and the absolute count of total memory B cells (30 per mul, 6.8% of B cells), with a prevalence of non-switched (CD27+IgD+) over switched (CD27+IgD-) memory B cells (4.3% versus 2.5% of B cells); anti-tetanus and anti-HBs immunoglobulin titers were protective, while anti-diphtheria immunoglobulin titers were not protective. The association of hypogammaglobulinemia and low switched B memory cells, in the absence of T cell immunodeficiency and of any other cause of immunodeficiency, allowed us to make the diagnosis of CVID in our patient, according to the European Society for
PMC10434558_02
Growth curve of the patient: after the initial phase of catch-up growth, the height velocity declines, and the stature slowly approaches the target height.
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The initial catch-up growth of the patient was good, with a height velocity of around 9 cm/year for the first two years of treatment, but this growth spurt coincided with his puberal development and decreased after four years of treatment ( Figure 2 ).