PMC7441430_01
Zosteriform vesicle-like papules, measuring 0.5-1.0 cm on the left breast. Pink or red, firm, and tender.
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fig1
The lesions were pink or red, firm, and tender (Figure 1).
Skin biopsy revealed (a) blue nodular lesions infiltrating in the dermis, composed of clustered heterogeneous tumor cells with glandular formation (H&E, magnification: x20); (b) some tumor cells were detected within vessels or lymphatic vessels (H&E, magnification: x40); (c) some cells were blue and transparent, and mitosis was significant (H&E, magnification: x200).
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fig2
Mitosis was significant (Figures 2(a)-2(c)).
Immunohistochemical stain highlighting the tumor cells, showing (a) CK-7, (b) EMA, and (c) TTF-1 positive.
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fig3
In immunohistochemistry, tumor cells were positive for cytokeratin (CK), cytokeratin-7 (CK7), thyroid transcription factor-1 (TTF1), and EMA and negative for cytokeratin-20 (CK20), carcinoembryonic antigen (CEA), and gross cystic disease fluid protein-15 (GCDFP-15) (Figures 3(a)-3(c)).