PMC8141474_01
Abnormal karyotype showing an extra chromosome 12 and a translocation t(14;18)(q32;q21)
gr1.jpg
PMC8141474_01_gr1.jpg
fig0001
This was confirmed on a follow up sample few weeks later (figure 1).
Two cells (metaphase and interphase) both showing one extra green signal (CEP12) suggestive of a trisomy 12. A normal pattern was observed for chromosome 13 (2 DLEU signals and 2 LAMP signals)
gr2.jpg
PMC8141474_01_gr2.jpg
fig0002
FISH images in two metaphase cells showing break-apart signals for BCL2 and IGH probes, resulting in one abnormal chromosome 14 and one abnormal chromosome 18: der(14) and der(18)
gr3.jpg
PMC8141474_01_gr3.jpg
fig0003