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Response to treatment in Case 1. (A) Calcium levels in relationship to denosumab administration and PRRT cycles in case 1; (B) Anterior view of 177Lu-LUTATHERA scintigraphy after I, II, and IV cycles of PRRT; (C) Posterior view of 177Lu-LUTATHERA scintigraphy after I, II, and IV cycles of PRRT.
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After the first cycle of treatment, PTHrP declined from 451 to 150 ng/l (see  Figure 2 ). Moreover, an objective tumor response was observed at CT evaluation after three cycles of treatment: hepatic lesions were reduced at VIII segment (44 x 36 vs 53 x 48 mm), IVa segment (25 x 23 vs 30 x 27 mm), and VI segment (26 x 19 vs 32 x 26 mm) (see  Figure 2 ).
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