PMC5784222_01
Gross appearance of the tumor. The cervix is surrounded by an irregular tumor (arrows), with erosion in the mucosal surface covered by mucinous layer.
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The cross-sectional area was gelatinous and some parts were covered with mucinous layer (Fig. 1).
Colloid carcinoma component is present in the deep area. Adenocarcinoma in situ (AIS), usual and intestinal types (inset), and endocervical adenocarcinoma (usual type) components are present in the superficial area (A). Colloid carcinoma cells and AIS intestinal type cells (inset) are positive for MUC2(B) and MUC5AC (C) and negative for MUC6 (D).
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On histopathological examination, the tumor deeply invaded the cervical wall (Fig. 2A). MUC5AC and negative for MUC6, and the tumor cells were positive for MUC2 but mucous lakes were negative for MUC2 (Fig. 2B-D). Mucous lakes and tumor cells of both colloid carcinoma and AIS intestinal type were positive for PAS, AB, and mucicarmine stains.