PMC6383178_01
Multiple bilateral lung nodules in CT scan.
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Serial CT scans revealed that two of the aforementioned pulmonary nodules had slightly increased in size (Fig. 1).
Gross appearance of one of the cysts. Note the thin wall of the cyst and the multiloculation.
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Both of these lesions were thin-walled and multiloculated and contained mucoid material. (Fig. 2).
H&E stain showing a benign biphasic lesion composed of mucinous glandular epithelium, and ovarian-like stroma. Original magnification (a,b) x 200, (c,d) x 400.
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The epithelial cells are positive for CK AE1/AE3 (a), EMA (b), MUC5AC (c) and TTF-1 (d). PAS/Diastase (k,l) highlighted diastase indigestible mucin. The stromal cells are focally positive for SMA (g), while diffusely positive for ER (f) and CD10 (e). Both cell types were negative for S100 (h), CD34 (i) and Inhibin (j).
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Immunohistochemistry showed that Cytokeratin AE1/AE3, EMA and TTF-1 are positive in the epithelial cells and negative in the stromal cells (Fig. 4a-c). MUC5AC is weakly positive at the surface of the epithelial cells. (Fig. 4d). The cells of the ovarian-like stroma are positive for estrogen receptors and CD10 and focally positive for SMA. (Fig. 4e and g). PAS, PAS/D and Mucicarmine special stains highlighted mucin in the cystic spaces and at the surface of the epithelial cells. (Fig. 4k-m). CD34, S100 and Inhibin are negative (Fig. 4h-j).