PMC7733341_01
(A) Fundus photograph showing active juxtamacular retinitis before treatment, (B) inactive lesion after treatment with intravitreal clindamycin, (C) spectral-domain optical coherence tomography showing hyperreflective spots in the vitreous, macular edema with intra- and sub-retinal fluid before treatment, hyperreflectivity of the neurosensory retina can be noted in the temporal aspect precluding the individualization of the different layers, (D) normal retinal thickness and foveal contour after treatment.
OPTH-14-4279-g0001.jpg
PMC7733341_01_OPTH-14-4279-g0001.jpg
f0001
A 40-year-old woman was diagnosed with ocular toxoplasmosis based on her presentation with a corrected distance visual acuity (CDVA) of counting fingers (CF) at 1 metre, 2+ vitreous cells, and an active juxtamacular retinitis (Figure 1A) in the right eye (RE). Spectral-domain optical coherence tomography (SD-OCT) of RE revealed macular edema with intra- and sub-retinal fluid, and vitreous hyperreflectivity (Figure 1C). At 2 months, CDVA was 6/6 with an inactive lesion and complete resolution of macular edema (Figure 1B and D).
PMC7733341_02
(A) Fundus photograph showing active juxtamacular toxoplasmic retinochoroiditis before treatment, (B) sharpening of lesion borders after treatment with intravitreal clindamycin, (C) spectral-domain optical coherence tomography showing elevation of the neurosensory retina and retinal pigment epithelium with the presence of intra- and sub-retinal fluid before treatment, hyperreflectivity of the neurosensory retina can be noted in the inferior nasal aspect precluding the individualization of the different layers, (D) normal foveal contour with evidence of retinal pigment epithelial and outer retinal atrophy after treatment.
OPTH-14-4279-g0002.jpg
PMC7733341_02_OPTH-14-4279-g0002.jpg
f0002
A 57-year-old woman presented with a CDVA of CF at 1/2 metre, 3+ vitreous cells, and focal juxtamacular retinochoroiditis (Figure 2A) in the RE. RE SD-OCT showed elevation of the neurosensory retina and retinal pigment epithelium (RPE) with the presence of intra- and sub-retinal fluid (Figure 2C). At 2 months, CDVA was 6/12, vitreous inflammation resolved, and the lesion remained quiescent with some evidence of outer retinal and RPE atrophy (Figure 2B and D).
PMC7733341_03
(A) Fundus photograph showing active juxtamacular focal retinitis before treatment, (B) sharpening of lesion borders after treatment with intravitreal clindamycin, (C) spectral-domain optical coherence tomography showing increased retinal thickness, subretinal fluid, and vitreous hyperreflectivity before treatment (D) normal retinal thickness and foveal contour after treatment.
OPTH-14-4279-g0003.jpg
PMC7733341_03_OPTH-14-4279-g0003.jpg
f0003
A 12-year-old boy was diagnosed with active toxoplasmosis based on his presentation with a CDVA of 6/18, 2+ vitreous cells, and focal juxtamacular retinitis (Figure 3A) in the RE. SD-OCT of RE revealed macular edema with increased retinal thickness, sub-retinal fluid, and vitreous hyperreflectivity (Figure 3C). One month later, CDVA improved to 6/6 with the sharpening of the lesion borders, resolution of vitritis and macular edema (Figure 3B and D).
PMC7733341_04
(A) Fundus photograph showing active juxtapapillary retinitis before treatment, (B) quiescent lesion after treatment with intravitreal clindamycin.
OPTH-14-4279-g0004.jpg
PMC7733341_04_OPTH-14-4279-g0004.jpg
f0004
A 22-year-old male presented with a CDVA of 6/9, 2+ vitreous cells, and an active juxtapapillary retinitis (Figure 4A) in the RE. CDVA improved to 6/6 at 1 month with a quiescent toxoplasmic lesion free of inflammation (Figure 4B).