PMC8502046_01
Clinical characteristics of the patient. Granulomas presented in the patient as multiple yellowish papuloplaques distributed in a grid pattern on the anterior of the neck were found at all injection sites. (A left view, B front view, C right view).
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A 54-year-old male presented with multiple relatively well-demarcated yellowish papuloplaques distributed in a grid pattern on the anterior of his neck (Figure 1).
Histopathological characteristics of the patient. Dermal granuloma was found on histological examination of lesional skin with a well-demarcating feature. Macrophages and multi-nucleated giant cells were found along the periphery of the granuloma. (A hematoxylin-eosin, x40, B hematoxylin-eosin, x200).
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Multi-nucleated giant cells were detected at higher magnification (Figure 2).
Immunohistochemistry of the patient. The granuloma of the patient was not immunohistochemically stained with PAS or Alcian blue, revealing no fungal infection or mucin deposition. (A PAS, x100, B Alcian blue, x100).
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Alcian blue staining was negative and Periodic acid-Schiff (PAS) staining did not reveal any fungal spores or hyphae (Figure 3).