PMC3370326_01
PMC3370326_02
Kidney biopsy, hematoxylin-eosin, and light microscopy. Enlarged hypocellular glomerulus with deposits of amorphous material (arrow). Magnification 300x.
cln-67-06-685-g001.jpg
PMC3370326_02_cln-67-06-685-g001.jpg
f1-cln_67p685
A kidney biopsy was performed and showed secondary amyloidosis as the main finding, which was associated with signs of acute tubular necrosis and interstitial nephritis (Figures 1 and 2).
Congo red staining shows apple-green birefringence on glomeruli (arrowheads) and tubules (double arrowheads). Not shown: tubules with degenerative changes, focal areas of necrosis and areas of interstitial nephritis. Normal blood vessels.
cln-67-06-685-g002.jpg
PMC3370326_02_cln-67-06-685-g002.jpg
f2-cln_67p685
A kidney biopsy was performed and showed secondary amyloidosis as the main finding, which was associated with signs of acute tubular necrosis and interstitial nephritis (Figures 1 and 2).
Top: Family pedigree. Bottom: Individual genotypes and corresponding DNA sequence chromatograms. The nucleotide position refers to the MEFV mRNA sequence, with the A of the start codon designated as nucleotide 1. WT: wild type. Individual II-1 was not evaluated.
cln-67-06-685-g003.jpg
PMC3370326_02_cln-67-06-685-g003.jpg
f3-cln_67p685
The diagnosis of FMF was based on clinical criteria (Table 1) and further refined by demonstration of M694V allele homozygosity in the MEFV gene (Figure 3).