PMC9154136_01
Multiple papules, nodules, and plaques with yellowish centers located over the pubis, vulva, and proximal left thigh area
IJD-67-71-g001.jpg
PMC9154136_01_IJD-67-71-g001.jpg
F1
Later, the patient evolved to erythroderma and multiple painless papules, nodules, and infiltrated rounded plaques with slightly raised borders, ranging from 3 mm to 1.5 cm in diameter, distributed over the pubis [Figure 1].
(a) Histopathologic examination of a punch biopsy specimen from a pubic lesion showing mixed inflammatory cell infiltrate, including numerous reactive lymphocytes, histiocytes, and scattered eosinophils, that are mixed with large atypical lymphoid cells in the dermis (hematoxylin and eosin stain, x10). (b) High-power view, demonstrating the presence of Reed-Sternberg cells (continuous arrow) and Hodgkin cells (dotted arrow) (hematoxylin and eosin stain, x40)
IJD-67-71-g002.jpg
PMC9154136_01_IJD-67-71-g002.jpg
F2
Punch biopsies performed on the pubic lesions and the erythrodermic skin showed a dermal mixed inflammatory cell infiltrate combined with atypical large lymphoid cells with large uni- or bi-nucleated "mirror image" nuclei and prominent eosinophilic nucleoli [Figure 2a and b].