PMC6398080_01
(a) Mild, focal mesangial hypercellularity, lobular architecture, and expanded matrix. The glomerular capillary wall is markedly and uniformly thickened. (b) Arteries are present and have mild arteriosclerosis. (c) Tubular atrophy involving less than 5% of the cortex.
CRIRH2019-1219529.001.jpg
PMC6398080_01_CRIRH2019-1219529.001.jpg
fig1
There was no necrosis, crescents, vasculitis, or focal segmental glomerulosclerosis (Figure 1).
Immunofluorescence pathology slides. Mesangium showing focal moderate granular staining along the (a) GBM IgG (trace to 1+), (b) GBM IgA (1+ to 2+), (c) GBM IgM (4+), (d) GBM C1Q (2+ to 3+), and (e) GBM C3 (1+ to 2+) and (f) electron microscopy slide. No globally sclerotic glomeruli, no significant podocyte foot effacement (about 10%), numerous amorphous electron dense deposits are predominantly subendothelial.
CRIRH2019-1219529.002.jpg
PMC6398080_01_CRIRH2019-1219529.002.jpg
fig2
Electron microscopy showed global glomerular capillary wall thickening, GBM duplication, and subendothelial deposits with no significant podocyte foot effacement (Figure 2).