PMC3271029_01
An abdominal computed tomography (CT) scan showing a heterogeneous mass (3 cm x 4 cm) located in the lower part of the stomach body. The tumor is indicated with an arrow.
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F1
Abdominal CT scan showed a well-defined, heterogeneous mass (3 x 4 m) which was located in the lower part of the stomach body (Figure 1).
Gastric endoscopy confirmed an ulcerated tumor with bleeding along the lesser curvature of the proximal stomach.
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F2
Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvature of the proximal stomach (Figure 2) and a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body (Figure 3).
Gastric endoscopy showing a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body.
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F3
Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvature of the proximal stomach (Figure 2) and a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body (Figure 3).
Macroscopic examination of a total gastrectomy specimen showing Borrman type-2 tumor measuring 5 x 6 cm (black arrow) and submucosal nodule measuring 3 x 4 cm in the stomach (white arrow).
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F4
Macroscopic examination of the total gastrectomy specimen showed Borrman type-2 tumor measuring 5 x 6 cm and submucosal nodule measuring 3 x 4 cm in the stomach (Figure 4).
Microscopic examination of the proximal tumor in the stomach demonstrating typical histological findings of adenocarcinoma (A). In addition, histopathological examination of the submucosal nodule revealed GIST of the low-risk category, composed of cytologically bland spindle cells with a low mitotic index (< 5) (B). Immunohistochemistry indicated strong staining for CD34 (C) and C-kit (D), while negative results were observed for S-100 (E) and SMA (F).
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F5
On histopathological examination, the Borrman type-2 tumor gastric tumor showed transmural infiltration by a poorly differentiated diffuse adenocarcinoma (Figure 5A). The immunohistochemistry indicated strong staining for CD34 and C-kit, while expressions of SMA and S-100 were negative (Figure 5B-F).