PMC5613689_01
Malignant peripheral nerve sheath tumor histologically showing fascicles of spindle cells (left) and necrosis (right) (HE, x100).
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Histologically, the material comprised focally necrotic tumor fragments, composed of atypical spindle to polygonal cells showing high mitotic activity, forming fascicles with focal palisading (Figure 1).
Angiosarcoma of the scalp. A gross appearance of the resected specimen, as seen from the skin surface (a) and epidural surface (b).
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In July 2016 the tumor was surgically resected (Figures 2(a) and 2(b)).
Angiosarcoma of the scalp. Histologically, the tumor was composed of aberrant vascular spaces, covered with atypical endothelial cells showing focal proliferation in the form of intraluminal buds ((a) HE, x100; (b) HE, x200). The tumor infiltrated the bone (asterisk) ((c) HE, x100). Tumor cells showing immunohistochemical expression of CD31 ((d) x200).
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Histologically, this tumor was composed of aberrant vascular, focally anastomosing spaces covered with atypical endothelial cells showing prominent nucleoli and high mitotic activity (Figures 3(a) and 3(b)). Tumor infiltrated through the bone (Figure 3(c)). Immunohistochemically, the tumor cells were diffusely positive for CD31 (Figure 3(d)), CD34, and Factor VIII.