PMC7477112_01
CT scan on day 3 showed bilateral, patchy alveolar opacities progressing to diffuse consolidations, with a "white lung" appearance and widespread ground-glass opacities and moderate bilateral pleural effusions.
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F1
On day 3, a chest computerized tomography (CT) without contrast showed severe lung injury (Figure 1).
PMC7477112_02
PMC7477112_03
(A) Before the first administration of canakinumab, the chest X-ray shows interstitial changes, ground glass opacities, and multifocal and bilateral effusions. (B) After second administration, the chest X-ray shows the extensive bilateral opacities and bilateral effusions, concomitant to bacterial superinfection.
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F2