PMC9702555_01
Sequential images of the primary lesion over 7 years, from the time of the first visit to the introduction of the second treatment.
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On day 13, CT revealed a good systemic response with all metastatic lesions, including brain metastases ( Figures 2C, D ), compared with baseline imaging ( Figure 1H ).
Therapeutic effect of brain metastasis using second-line treatment selpercatinib.
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On day 13, CT revealed a good systemic response with all metastatic lesions, including brain metastases ( Figures 2C, D ), compared with baseline imaging ( Figure 1H ).
PMC9702555_02
Sequential images of the primary lesion over 7 years, from the time of the first visit to the introduction of the second treatment.
fonc-12-1019932-g001.jpg
PMC9702555_02_fonc-12-1019932-g001.jpg
f1
On day 13, CT revealed a good systemic response with all metastatic lesions, including brain metastases ( Figures 2C, D ), compared with baseline imaging ( Figure 1H ).
Therapeutic effect of brain metastasis using second-line treatment selpercatinib.
fonc-12-1019932-g002.jpg
PMC9702555_02_fonc-12-1019932-g002.jpg
f2
On day 13, CT revealed a good systemic response with all metastatic lesions, including brain metastases ( Figures 2C, D ), compared with baseline imaging ( Figure 1H ).
Pathologic findings from the first diagnostic cell block showed adenocarcinoma in the presence of many lymphocytes (A, B, H&E staining, original magnification x 400). A re-biopsy sample also showed adenocarcinoma with an alveolar, ductal structure (C, D, H&E staining, original magnificationx200 andx400, respectively). Fusion KIF5B-exon 15; RET-exon 12 was detected by PCR/NGS assay from first diagnostic specimens, and NGS assay from re-biopsy specimens.
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PMC9702555_02_fonc-12-1019932-g003.jpg
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RET from formalin-fixed paraffin-embedded (FFPE) specimens from 7-year-old pleural effusion cell blocks ( Figures 3A, B ), which were morphologically similar to re-biopsy sample in terms of malignant cells with large nucleoli ( Figures 3C, D ). RNA (1256 ng) was collected from the initial cell block sample, with an RNA integrated number (RIN) value of 4.8. A K15RET12 fusion peak was detected by single-plex polymerase chain reaction (PCR) ( Figure 3 ) and NGS assay.