PMC9492836_01
Timeline of relevant data, interventions, and outcomes.
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F1
Consequently, she was admitted to our rehabilitation center on August 5, 2020, for further observation (Timeline Figure 1, full details in Supplementary material). MRI showed that the lesion was mainly confined to the left precentral gyrus (Supplementary Figure 1).
MRI results. (A-C), diffusion tensor tractography of the corticospinal tract (CST). (A) Regions of interest (ROI) for reconstructing the CST are located at the precentral gyrus (red color, obtained from the AAL90 template), the posterior limb of the internal capsule (yellow color), and the cerebral peduncle (green color) on the fractional anisotropic (FA) map. (B) A coronal view of the bilateral CSTs (blue color) from the healthy control. The red, yellow, and green areas represent the ROI of the precentral gyrus, the posterior limb of the internal capsule, and the cerebral peduncle. (C) A coronal view of bilateral CSTs from the patient at t1 (5 weeks) and t4 (45 weeks). On the left of the C map (t1), the cyan region is the lesion registered from T1 space to FA space. (D,E) activation during passive unaffected (left) and affected (right) hand movements of the patient and healthy control. (D) Activation of passive movement of the patient at t1, t3 (12 weeks), and t4; (E) activation of passive movement of healthy control. Color bar = t-value. The left side indicates the left hemisphere. L, left; R, right.
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F2
The individual axial FA map indicated the posterior limb of the internal capsule and the cerebral peduncle (Figure 2A). Tractography was performed on healthy control (Figure 2B) and a t1 and t4 scan of the patient (Figure 2C). The brain activation pattern of passive movement of unaffected hands of the patient was similar to that of healthy control, showing dominant contralateral activation and less ipsilateral activation (Figures 2D,E).