PMC5824522_01
Intraoral swelling on the palate having intact margins
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F1
Clinical examination showed 1 cm x 1 cm sized, firm swelling with normal overlying mucosa [Figure 1].
Gross specimen measuring 1.5 cm x 1.5 cm x 1 cm
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F2
Cut surface was firm and gray-white with no areas of hemorrhage, necrosis or cystic change [Figure 2].
Histopathological image showing a well-circumscribed lesion composed of multiple cystic spaces (H&E, x40)
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F3
Under low magnification, hematoxylin and eosin-stained sections revealed, a well-circumscribed lesion composed of superficial and deep-seated keratin-filled multicystic spaces of variable size and shape [Figure 3].
Histopathological image showing tumor stroma showing large number of cystic spaces having keratotic lamellae and lined by squamous cells (H&E, x200)
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F4
Within the stroma, a large number of cystic spaces, gland-like tubular structures, tumor islands and mucous cells could be seen [Figures 4 and 5]. Most of the cystic spaces contained keratotic lamellae, some contained eosinophilic material and some were empty [Figure 4].
Histopathological image showing tumor stroma having numerous gland-like tubular structures (H&E, x100)
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F5
Within the stroma, a large number of cystic spaces, gland-like tubular structures, tumor islands and mucous cells could be seen [Figures 4 and 5].
Histopathological image showing tumor stroma showing tumor cells composed of basaloid, plasmacytoid and angular cells (H&E, x400)
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F6
The tumor cells, dispersed throughout the stroma, were pleomorphic with shapes being basaloid, plasmacytoid, angular or elongated [Figure 6].
Histopathological image showing presence of mucous cells containing mucin (Periodic acid-Schiff stain, x200)
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F7
Periodic acid-Schiff staining revealed the presence of mucin in some cystic areas [Figure 7].