PMC9918330_01
Signet ring cell carcinoma infiltrating the bladder. Microscopic appearance using haematoxylin and eosin stain; original magnification: 100x
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FIG1
She underwent a bladder ultrasound, which revealed "bladder thickening and left pyelocaliceal dilatation; a transurethral resection of a 4cm lesion of the bladder fundus revealed an adenocarcinoma with signet ring cell morphology compatible with a bladder metastasis of the gastric neoplasia" (Figure 1).
PMC9918330_02
Malignant epithelial neoplastic structures of adenocarcinomas invading the bladder. Microscopic appearance using haematoxylin and eosin stain; original magnification: 100x
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FIG2
Biopsy of the bladder lesion revealed tissue fragments with malignant epithelial neoplasm, and an immunohistochemical profile compatible with bladder metastasis of colonic origin (Figures 2, 3): caudal-type homeobox transcription factor 2 (CDX2) +, cytokeratin (CK) 7-, CK20-, GATA binding protein 3 (GATA3), and thyroid transcription factor (TTF-1).
Immunohistochemistry revealing Caudal-type homeobox transcription factor 2 (CDX2) positive tumour cells. Original magnification: 100x
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FIG3
Biopsy of the bladder lesion revealed tissue fragments with malignant epithelial neoplasm, and an immunohistochemical profile compatible with bladder metastasis of colonic origin (Figures 2, 3): caudal-type homeobox transcription factor 2 (CDX2) +, cytokeratin (CK) 7-, CK20-, GATA binding protein 3 (GATA3), and thyroid transcription factor (TTF-1).
PMC9918330_03
18F-FDG PET showing penile metastasis. FDG PET: Fluorodeoxyglucose positron emission tomography
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FIG4
In this context, he performed an abdominopelvic nuclear magnetic resonance (AP NMR) and an 18- fluorodeoxyglucose positron emission tomography (PET), which revealed an extensive penile mass causing obliteration of the penile urethra (Figure 4).
Malignant epithelial neoplastic structures of adenocarcinoma invading the penile structures. Microscopic appearance using haematoxylin and eosin stain; original magnification: 100x
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FIG5
A biopsy was performed on the penile lesion, and its histology revealed malignant epithelial neoplastic structures of adenocarcinoma with an immunohistochemical profile of CK20+, CDX2+ and CK7-, compatible with metastatic neoplasia from primitive adenocarcinomas of the colon/rectum (Figures 5, 6).
Immunohistochemistry cytokeratin 20 (CK20) positive tumour cells. Original magnification: 100x
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FIG6
A biopsy was performed on the penile lesion, and its histology revealed malignant epithelial neoplastic structures of adenocarcinoma with an immunohistochemical profile of CK20+, CDX2+ and CK7-, compatible with metastatic neoplasia from primitive adenocarcinomas of the colon/rectum (Figures 5, 6).