PMC5362917_01
(a) Cytological examination revealed moderate cellularity smears composed of epithelial cell clusters consisting of an exclusive population of oncocytic cells seen in sheets and papillary clusters, along with abundant single cells (magnification x 40). (b) Moderate-to-abundant densely stained granular cytoplasm with round nuclei and indistinct nucleoli (magnification x 100)
10.1177_2055116917693491-fig1.jpg
PMC5362917_01_10.1177_2055116917693491-fig1.jpg
fig1-2055116917693491
Intracellular eosinophilic materials were also found (Figure 1).
The tumours were mahogany/dark reddish brown, well circumscribed and contained a central scar (approximate size 2.83 cm x 2.2 cm x 3.5 cm). A rim of compressed normal renal parenchyma was found
10.1177_2055116917693491-fig2.jpg
PMC5362917_01_10.1177_2055116917693491-fig2.jpg
fig2-2055116917693491
(a) The tissue was composed of solid nests, anastomosing cords and closely packed glands separated by a delicate fibrovascular stroma (haematoxylin and eosin, x 10). (b) Individual neoplastic cells were cylindrical to polyhedral in shape, had distinct cell borders and contained moderate amounts of finely granular eosinophilic cytoplasm and round-to-oval nuclei (haematoxylin and eosin, x 40). (c) Chromogranin negative (magnification x 40). (d) Cytokeratin positive (magnification x 40). (e) Neuron-specific enolase negative (magnification x 40). (f) Vimentin negative (magnification x 40)
10.1177_2055116917693491-fig3.jpg
PMC5362917_01_10.1177_2055116917693491-fig3.jpg
fig3-2055116917693491
Individual neoplastic cells were cylindrical to polyhedral in shape, had distinct cell borders and contained moderate amounts of finely granular eosinophilic cytoplasm and round-to-oval nuclei (Figure 3). The neoplastic cells were negative for chromogranin A, neuron-specific enolase and vimentin, indicating that the origin was not mesenchymal or neuronal/neuroendocrine (Figure 3b).
The neoplastic cells were interconnected via junctional complexes and contained numerous round-to-oval, electron dense mitochondria (x 2500 electron microscope)
10.1177_2055116917693491-fig4.jpg
PMC5362917_01_10.1177_2055116917693491-fig4.jpg
fig4-2055116917693491
Ultrastructurally, neoplastic cells were interconnected via junctional complexes and contained numerous round-to-oval, electron-dense mitochondria (Figure 4).