PMC4829625_01
An example of the individual management of cervical cancer FIGO stage IB1 in pregnancy (case 5, after). a Colposcopy in pregnancy was performed at initial diagnosis and subsequently during neoadjuvant chemotherapy to monitor the response to treatment; acetic acid was used for the visualization of cervical changes. Signs of invasive disease included atypical vessels and ulceration (arrow). b A pelvic MRI scan was performed at 20 wks GA and ruled out lymph node involvement; the sagittal T2-weighted image identifies the tumor by an increase in size and signal intensity (arrow). c Representative images of Ki-67 expression in non-treated and treated SCC visualized by immunohistochemistry (brown, arrow); hematoxylin (blue) was used for nuclear staining (bright field image, x100 magnification)
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Fig1
Clinical and colposcopic follow-ups were scheduled every 3 weeks confirming stable disease (Fig. 1a). Systems, Best, Netherlands) to rule out lymph node involvement and advanced disease (Fig. 1b). Staging laparoscopy was refused by the patient. The pathologic examination revealed a Ki-67 activity of 36.47 % after neoadjuvant chemotherapy compared to a proliferation index of 32.22 % at initial diagnosis suggesting stable disease (Fig. 1c).