PMC8212948_01
(A) Chest computed tomography showing multifocal and confluent consolidations with ground-glass attenuation in >50% of the pulmonary parenchyma. (B) Echocardiogram showing left coronary artery dilatation (red arrow).
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F1
Chest computed tomography showed bilateral ground-glass opacities diffusely distributed with consolidated areas in the right lung (Figure 1A). Echocardiography showed dilation of the left coronary artery trunk (Figure 1B), corroborating the diagnosis of Multisystemic Inflammatory Syndrome in Children (MIS-C) with a "Kawasaki-like" disease.
Kidney biopsy showing lupus nephritis and thrombotic microangiopathy findings. (A) Histological sections demonstrate proliferative glomerulonephritis and fibrin thrombi in afferent arteriole (trichrome stain, 400x). (B) Immunofluorescence staining revealed fibrin deposition within the intravascular thrombi (fibrinogen antiserum, 400x).
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F2
Immunofluorescence showed 12 glomeruli under study conditions with the following findings: IgG ++, IgA +, IgM ++, C3 ++, fibrinogen ++, kappa ++, lambda ++, and C1q ++, which was compatible with "Full-House" Nephropathy, thrombotic microangiopathy and advanced chronic kidney disease (Figures 2A,B).