PMC4929373_01
Pathological findings of primary sigmoid colon cancer and metastatic ovarian tumor. The primary sigmoid colon cancer (a) represents a moderately differentiated adenocarcinoma, and the metastatic ovarian tumor (b) is also identified as an adenocarcinoma. Both the sigmoid colon cancer and ovarian tumor show negative staining for CK7 (c: sigmoid colon cancer; d: ovarian tumor) and positive results for CK20 (e: sigmoid colon cancer; f: ovarian tumor).
crg-0010-0199-g01.jpg
PMC4929373_01_crg-0010-0199-g01.jpg
F1
The pathological finding was moderately differentiated adenocarcinoma (fig. 1a), and the UICC TNM classification was T2, Nx, M0. The pathological finding was adenocarcinoma, similar to the sigmoid colon cancer (fig. 1b). The sigmoid colon cancer showed negative staining for CK7 and positive staining for CK20, as is usually seen in the majority of colorectal cancers (fig. 1c, e). The left ovarian tumor also showed negative staining for CK7 and positive staining for CK20, compatible with its colon cancer origin (fig. 1d, f).
MRI in March 2006 showed multiple metastatic tumors approximately 18 mm in diameter as well as surrounding brain edema in the bilateral frontal lobes (a). After GKS, the tumors had reduced in size by May 2006 (b).
crg-0010-0199-g02.jpg
PMC4929373_01_crg-0010-0199-g02.jpg
F2
March 2006, convulsions of the left arm and leg were noted, followed by weakness of the left leg as well as gait disturbance. Magnetic resonance imaging (MRI) showed metastases in the bilateral frontal lobes (fig. 2a). After GKS, the patient was able to walk and the tumors were reduced in size (fig. 2b).
MRI in November 2006 showed recurrent brain metastasis approximately 20 mm in diameter in the left frontal lobe (a). MRI in February 2007 showed that GKS was effective in controlling the lesion (b).
crg-0010-0199-g03.jpg
PMC4929373_01_crg-0010-0199-g03.jpg
F3
During the administration of FOLFOX, recurrence of a brain metastasis in the left frontal lobe was noted (fig. 3a). In November 2006, GKS for the recurrent brain metastasis was performed and was effective in controlling the lesion (fig. 3b).