PMC5816321_01
1a,b - Clinical manifestation of a 78-year-old female patient with NF 1 and ventricular polyposis; 1c,d,e,f - Clinical manifestation of NF1 in both patient's daughters
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F1
Clinical examination revealed multiple nodular and tumour-like formations, measuring from 1 to 5 cm, disseminated on the whole body and extremities, with a smooth surface and regular borders (Fig. 1a). The same clinical findings were observed in patient's daughters, both of them with long-standing duration and progressive behaviour for dissemination (Fig. 1b,c,d,e).