PMC7748904_01
Effects of quetiapine on QTc on a patient with Wolff-Parkinson-White (WPW) Syndrome. This graph represents changes in the QTc interval expressed in milliseconds at various points in time including at baseline, 2, 24, and 48 hours postoverdose and then finally a year after.
CRIPS2020-6633385.001.jpg
PMC7748904_01_CRIPS2020-6633385.001.jpg
fig1
Two hours postoverdose, the patient began to exhibit a prolonged QTc interval of 486 ms which contrasted with her QTc baseline of 445 ms (Figure 1). Forty-eight hours after discontinuation of her medication, the patient's EKG normalized including her QTc interval (QT/QTc of 414/434) (Figure 1), and her PR interval was at 160 ms (Table 1). Twenty-four hours later her EKG showed a QTc interval of 457 ms, PR interval of 170 ms, and heart rate of 89 bpm (Figure 1).