PMC10082601_01
Paradoxical palmoplantar pustulosis lesions on patient's soles (A), after 3 months treatment with secukinumab (B) and 10 months treatment with ixekizumab (C).
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After half year of adalimumab treatment, a painful eruption of pustules on both palms and soles developed (Figure 1A) along with scaly plaques on his scalp and left lower limb (Palmoplantar Pustulosis Area Severity Index, PPPASI: 26). However, after 3 months of secukinumab treatment with a dosage of 300mg per injection, his lesions were not improved (Figure 1B) (PPPASI: 36). After 10 months follow-up, his paradoxical psoriasis went into complete remission (Figure 1C).