PMC9617483_01
papulo-nodular pigmented, firm, fixed mass (gross); (A) dermis showing proliferation of monomorphic spindle shaped cell along with moderate infiltration of inflammatory cells and dilated congested blood vessels (H&E, 100X); (B) cells arranged in storiform pattern; individual cell showing oval to spindled vesicular nucleus with moderate to abundant eosinophilic cytoplasm; (C) scattered intra and extracellular brown pigment is also noted (H&E, 200X); (D) immunohistochemistry for CD34 is diffusely positive in neoplastic cells (IHC, 200X)
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F1
Clinical findings: patient-1 showed a papulo-nodular, pigmented, firm, tender swelling with restricted mobility (Figure 1 A). Primarily benign spindle cell tumour diagnosis was kept with further characterization by immunohistochemistry (IHC) (Figure 1 B,C). Black (HMB)-45, Caldesmon, Melan A. Based on the histomorphology and immunohistochemistry, a diagnosis of pigmented dermatofibrosarcoma was rendered (Figure 1 D).