PMC3242356_01
In vivo human RPE and choroidal GAPDH and nitrotyrosine. Ischemic choroid and RPE (A) demonstrate GAPDH nuclear translocation in RPE and vascular endothelial cells (C) as well as considerable immunoreactive nitrotyrosine (E). RPE and choroid of control eye shows only cytoplasmic GAPDH and minimal nitrotyrosine (B,D,F). Bar = 25 mum.
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F1
The eye revealed arteriolosclerosis and infarction of the optic nerve and surrounding portions of the choroid and outer retina as well as adjacent ischemia, all consistent with occlusion of short posterior ciliary artery perfusion (Figure 1A).