PMC8034790_01
18F-fluorodeoxyglucose positron emission tomography with computed tomography scan images (a) Maximum-intensity projection images, (b and c) axial computed tomography and fused positron emission tomography with computed tomography images of hypermetabolic lesion in the distal left ureter and right seminal vesicle, respectively, (d) coronal computed tomography and fused positron emission tomography with computed tomography images showing left mild hydroureteronephrosis and diffusely increased 18F-flourodeoxyglucose uptake in the cortex of the left kidney, (e) fused positron emission tomography with computed tomography images of hypermetabolic lesion in the shaft of the penis
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F1
Hypermetabolic lesions were also found in the right seminal vesicle (SUVmax 18.2) and in the shaft of the penis involving corpora cavernosa and corpus spongiosum (SUVmax 7.1) [Figure 1a-e].
Histopathology and immunohistochemistry images of diffuse large B-cell lymphoma, not otherwise specified: (a) Sheets of intermediate-sized mononuclear cells (H and E, x400), Immunohistochemistry of atypical cells was diffusely positive for - (b) CD20 (x400), (c) BCL2 (x400), (d) MUM1 (x400) and negative for (e) CD3 (x400), (f) CD138 (x400), and (g) Cyclin D1 (x400), (h) high proliferation with Ki67 labeling index (x400)
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F2
The patient underwent left ureteroscopy and mucosal biopsy of the left distal ureteric lesion due to easy accessibility which revealed intermediate-sized atypical mononuclear cell infiltrate [Figure 2a]. Immunohistochemistry was positive for CD20, BCL2, and MUM1 and negative for CD3, CD138, BCL6, CD23, CD5, CD10, and Cyclin D1 with high proliferation on Ki-67 index, consistent with DLBCL, not otherwise specified, immunohistochemical subgroup nongerminal center B-cell type [Figure 2b-2h].