PMC8666494_01
Physical findings showed a giant left breast mass measuring 20 cm x 20 cm in diameter with ulceration of the overlying skin.
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Physical examination revealed a large, firm and mobile left breast mass measuring 20 cm x 20 cm, with three ulcerated lesions and peau d'orange skin changes (Figure 1).
Histopathologic examination of the tumor showed stromal hypercelluarity with mild nuclear atypia. Hematoxylin and eosin staining at 400x showed atypical stromal cells showed hyperchromatic nuclei, prominent nucleoli and occasional mitoses. (A) Immunohistochemical staining showed expression of estrogen receptors (B) and progesterone receptors. (C) Note the leaf-like architecture consisting of elongated cleft-like spaces containing papillary projections of epithelial-lined stroma with hyperplasia.
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All these histological features were consistent with a benign phyllodes tumor (Figure 2).