PMC3263006_01
Sagittal MRI with contrast shows midline dural-based frontal fossa mass with a separate "cap-like" mass and surrounding vasogenic edema
SNI-2-181-g002.jpg
PMC3263006_01_SNI-2-181-g002.jpg
F1
Magnetic resonance imaging (MRI) demonstrated a very large intracranial frontal fossa mass with significant bifrontal edema [Figure 1].
Microscopic review of dual pathologies. (a) Low-power view of meningioma containing foci of large B-cell lymphoma; the latter is characterized by dense aggregates of cells having marked nuclear enlargement and hyperchromasia. (b) Enlarged cells of B-cell lymphoma (left) and contiguous meningioma (right); an intranuclear pseudoinclusion is present in the meningothelial component. (c) Immunohistochemical staining for CD20, a B-cell marker, demonstrates diffuse positivity in the tumor cells. Non-staining, arch-shaped vascular endothelium is present in the upper half of the field
SNI-2-181-g003.jpg
PMC3263006_01_SNI-2-181-g003.jpg
F2
Figure 2 illustrates the malignant lymphoma interdigitating with the WHO grade I meningioma.