PMC8005656_01
Imaging results for the patient. CT showed that the transmittance of both lungs decreased, and there were many high-density nodular lesions with clear boundaries and cavities in both lungs (A-D) and enhanced CT scan of the chest and abdomen showed thymic dysplasia, diffuse pulmonary nodules (E, F) and liver nodules (G, H). Abdominal MRI showed many short T2 signal sites in (I, J) liver and kidney (K, L). The original bilateral lung fields were absorbed after treatment (M, N).
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CT showed that the transmittance of both lungs decreased, and there were many high-density nodular lesions with clear boundaries and cavities in both lungs ( Figures 1A-D ). Her thymus was small ( Supplementary Figure 1 ), which may have led to an abnormal number and function of T lymphocytes, suggesting the possibility of immunodeficiency.
Representative images of Talaromyces marneffei colonies. Clones appeared on the 3rd day when cultured in Sabouraud medium at 28 C (A). A light grey-brown film with a diameter of approximately 3-5 mm was noted. A typical red product developed. A clone cultured at 28 C was selected to prepare a bacterial smear and was observed under a high-magnification microscope (B). Branched, colorless and transparent mycelium was observed.
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During the treatment period, the patient's body temperature increased, and a rash appeared ( Supplementary Figure 2 ).