PMC3825694_01
An ulcerated metastatic nodule on the chest region is observed.. Note: Other metastatic lesions over the chest and reconstructed breast are also present.
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Multiple erythematous painful nodules from 5 mm to 2 cm were distributed on her chest and over the reconstructed breast (Figure 1).
Microphotograph of immunoperoxidase staining of a metastatic cutaneous lesion of the patient.. Notes: Neoplastic cells in the dermis show a strong reaction with anti-mucin 1 monoclonal antibody (HMFG1 monoclonal antibody) with a mixed pattern.
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By immunohistochemistry, MUCI expression was studied and a strong reaction was found with a mixed pattern at the plasma membrane and in the cytoplasm (Figure 2).
Breast cancer cutaneous metastasis.. Notes: Tumoral malignant cell nests passing through the epidermis are observed. Mucin 1 expression is found at the epidermal borders and at the tumor cells. The pattern of expression is cytoplasmic.
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The epidermis showed no signals of ulceration (Figure 3), and in some malignant cells, a MUCI moderate reaction was found.