PMC7393264_01
MRI of DMG. (A) Axial T2-weighted MR images. (B) Axial T1-weighted postcontrast MR images. These images demonstrate a well-circumscribed mass (arrows), and best response among responses assessed with the Response Assessment in Neuro-Oncology criteria was stable disease. (C) Immunohistochemical stain demonstrating WT1 protein in the nucleus and cytoplasm of tumor cells, with greater staining intensity in the cytoplasm:a previously known histopathological feature for primary astrocytic tumors (x400). (D) Immunohistochemical stain demonstrating the H3.3K27M mutation in the nucleus of tumor cells, displaying highly anaplastic, pleomorphic tumor cells with abnormal nuclear morphology:histopathological evidence supporting the diagnosis of histological grade IV glioma (x400). MRI, magnetic resonance imaging; DMG, diffuse midline glioma; RANO, response assessment in neuro-oncology.
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F1
Along with these improvements, MRI at week 8 of vaccination revealed obvious reductions in the high signal intensity of the lesion on T2-weighted (Figure 1A) and contrast-enhanced T1-weighted postcontrast (Figure 1B) images.