PMC8008077_01
Fluid attenuated inversion recovery (a) and T2 turbospin echo sequence (b) demonstrating high signal intensity in the dentate nuclei bilaterally (white arrows).
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T2 turbospin echo, fluid attenuated inversion recovery (FLAIR) and echo-planar diffusion-weighted sequences, which all showed increased signal in the dentate nuclei (Figure 1).
Diffusion-weigthed imaging (a) indicating increased signal in the splenium of the corpus callosum and corresponding apparent diffusion coefficient map (b) showing a decreased signal in this area in keeping with restriction.
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Diffusion signal was, however, also noted in the splenium of the corpus callosum, which showed no discernible T2 or FLAIR signal, and in this location there was evidence of diffusion restriction with low signal on the ADC map suggesting cytotoxic oedema (Figure 2).
Fluid attenuated inversion recovery imaging at the 7-week follow-up imaging, demonstrating resolution of the previous dentate nuclei high signal; compare with Figure 1.
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A follow-up scan approximately 7 weeks later (Figures 3-4), after cessation of metronidazole, showed complete clearing of the previous signal in the dentate nuclei and splenium of the corpus callosum.
(a) Diffusion sequence showing resolution of the splenium lesion at follow up (b) Apparent diffusion coefficient map showing complete resolution of the splenium lesion at follow up imaging; compare with Figure 2.
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A follow-up scan approximately 7 weeks later (Figures 3-4), after cessation of metronidazole, showed complete clearing of the previous signal in the dentate nuclei and splenium of the corpus callosum.