PMC1334206_01
Lymph node infarction with viable rim of sub capsular lymphoid tissue. (40X, H & E) Inset: Note the cellular outlines of the individual lymphocytes, which have undergone coagulative necrosis. (400X, H&E).
1472-6890-5-11-1.jpg
PMC1334206_01_1472-6890-5-11-1.jpg
F1
On microscopy, two of the lymph nodes (including the largest one) showed near total infarction of the parenchyma with preservation of cellular outlines of the lymphocytes (Fig 1).
Perinodal blood vessels show marked congestion (H&E-40X), and fibrin thrombi (Inset-H&E-100X).
1472-6890-5-11-2.jpg
PMC1334206_01_1472-6890-5-11-2.jpg
F2
The medullary vessels showed vascular congestion however the blood vessels in the perinodal adipose tissue showed multiple fibrin thrombi with congestion in some of the vessels (Fig 2).
CD20 immunohistochemistry highlights the viable subcapsular lymphoid tissue, where as the adjacent infarcted area also shows focal positivity (H&E-200X).
1472-6890-5-11-3.jpg
PMC1334206_01_1472-6890-5-11-3.jpg
F3
T-cells. The infarcted tissue showed variable positivity and these markers highlighted few reactive follicles (Fig 3). The uninvolved lymph nodes also showed a normal positivity pattern.