PMC5871390_01
A: severe oral mucositis with hemorrhagic crusts
B: papules with central necrosis in the pre-sternal region.
C: involvement in areas of pressure. D:
significant improvement after suspension of medication and replacement of
folinic acid
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PMC5871390_01_abd-93-01-0155-g01.jpg
f1
She developed severe oral mucositis along with papules with central necrosis in the presternal region (Figure 1). Interestingly, areas of pressure were markedly involved (Figure 1). The patient showed significant clinical and laboratory improvement after suspension of medication and replacement of folinic acid (Figure 1).
Light microscopy with necrosis of epidermis A: and oral
mucosa B: Hematoxylin & eosin, X400
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PMC5871390_01_abd-93-01-0155-g02.jpg
f2
Light microscopy of the oral mucosa and the affected skin showed epidermal basal necrosis with discreet and superficial inflammatory infiltrate (Figure 2).