PMC6450628_01
Bone marrow histology at the time of aplastic anemia diagnosis in patients with previous history of Hodgkin Lymphoma.. The hematoxylin and eosin (H&E) stained bone marrow histology sections at 25x, 50x, and 100x magnification reveal severely reduced cellularity and reduced trilineage hematopoiesis of Patient 1 (A), Patient 2 (B), and Patient 3 (C).
pone.0215021.g001.jpg
PMC6450628_02_pone.0215021.g001.jpg
pone.0215021.g001
PMC6450628_02
Bone marrow histology at the time of aplastic anemia diagnosis in patients with previous history of Hodgkin Lymphoma.. The hematoxylin and eosin (H&E) stained bone marrow histology sections at 25x, 50x, and 100x magnification reveal severely reduced cellularity and reduced trilineage hematopoiesis of Patient 1 (A), Patient 2 (B), and Patient 3 (C).
pone.0215021.g001.jpg
PMC6450628_02_pone.0215021.g001.jpg
pone.0215021.g001
Clinical Course of patients with Hodgkin Lymphoma and Aplastic Anemia.. A schematic diagram demonstrating the clinical course of 15 patients with diagnoses of HL and AA. Patient reported by Brusamolino et al. is not shown because of incomplete clinical information. Blue triangle, HL diagnosis; red circle, AA diagnosis; black triangle, death; green cross, last follow-up. Treatments for HL and AA are denoted by black vertical lines, with treatment and response listed above the respective line. HL, Hodgkin Lymphoma; AA, Idiopathic Acquired Aplastic Anemia; ABVD, Doxorubicin, Bleomycin, Vinblastine, Dacarbazine; ASHAP, Doxorubicin, Solumedrol, Cytarabine, Cisplatin; MOPP, Mechlorethamine, Vincristine, Procarbazine, Prednisone; MTNI, Modified Total Nodal Irradiation; C-MOPP, Cyclophosphamide, Vincristine, Procarbazine, Prednisone; CHOP, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone; Allo BMT, Allogenic Bone Marrow Transplant; hATG, Horse Antithymocyte Globulin; ATG, Antithymocyte Globulin; ALG, Antilymphocyte Globulin, CsA, Cyclosporine A; Tac, Tacrolimus; G-CSF, Granulocyte Colony Stimulating Factor; CR, Complete Response; PR, Partial Response; NR, No Response.
pone.0215021.g002.jpg
PMC6450628_02_pone.0215021.g002.jpg
pone.0215021.g002
A in S1 Appendix). After a detailed review, we identified eight articles that included a total of 12 cases where HL patients were also diagnosed with AA (Fig 2, Table 2).