PMC3862332_01
Pre-operative MRI showing the tumor, affecting both anterior and posterior cervical lips, with possible early involvement of the vaginal fornices. Clear fat plains where observed between the tumor and bladder anteriorly and rectosigmoid posteriorly.
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A biopsy was taken and the histopathology showed a poorly differentiated malignant tumor (Fig. 1).
Postoperative radical hysterectomy specimen showing the cervical tumor through adequate vaginal cuff.
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Immunohistochemistry showed strong positivity for S100 (Fig. 2), vimentin, melanin-A, MITF and patchy positivity for HM45 (Fig. 3).
Immunohistochemistry (IHC) images H&E at x 200 magnification.
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There was possible involvement of vaginal fornices but no evidence of parametrial involvement (Supplementary Fig. 4). There was possible involvement of vaginal fornices but no evidence of parametrial involvement (Supplementary Fig. 4).
Immunohistochemistry (IHC) images for S100 at x 200 magnification.
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Figs. 5 and 6). Final histopathological report verified the presence of a cervical malignant melanoma measuring in total 33 x 22 x 35 mm, obscuring the external os and extending into the endocervical canal. Figs. 5 and 6). Final histopathological report verified the presence of a cervical malignant melanoma measuring in total 33 x 22 x 35 mm, obscuring the external os and extending into the endocervical canal.
Immunohistochemistry (IHC) images for HMB45 at x 200 magnification.
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Figs. 5 and 6). Final histopathological report verified the presence of a cervical malignant melanoma measuring in total 33 x 22 x 35 mm, obscuring the external os and extending into the endocervical canal. Figs. 5 and 6). Final histopathological report verified the presence of a cervical malignant melanoma measuring in total 33 x 22 x 35 mm, obscuring the external os and extending into the endocervical canal.