PMC9259366_01
A 45-year-old female presented with proptosis, periorbital fullness, and movement limitation in the right eye (a-c). Orbital MRI demonstrates a large orbital mass in the lateral part of the right orbit that spreads to the orbital apex and pushes the optic nerve medially. The mass is isointense to the brain tissue in T1- (d) and T2-weighted (e) images and enhances homogeneously in T1-weighted fat saturation (f).
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fig1
On examination, the right eye had nonaxial proptosis assessed by Hertel exophthalmometer and limitation in the movements, particularly lateral and upward rotation (Figure 1). Postcontrast T1-weighted images disclosed remarkable enhancement of the mass (Figure 1).
(a) Photomicrograph of orbit with well-differentiated squamous cell carcinoma showing an infiltrative growth pattern of epithelial cells with some keratin pearls (asterisk) (low power field, x100, H&E staining). (b) Photomicrograph from orbital well-differentiated squamous cell carcinoma revealing squamous neoplastic epithelial cells with intercellular desmosomes and keratin pearls (arrowhead) (high power field, x400, H&E staining). (c) Photomicrograph from the perineural invasion of orbital squamous cell carcinoma (arrow) (medium power field, x200, H&E staining).
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fig2
The histopathologic findings were consistent with a well-differentiated invasive SCC, mixed small and large cell keratinizing type (Figure 2).