PMC8101659_01
A - Photomicrograph of peripheral blood smear showing lymphocytosis comprising atypical lymphoid cells; B - Photomicrograph of bone marrow aspirate exhibiting dual population of atypical lymphoid cells - small CLL lymphocyte (arrow) and prolymphocytes (arrowheads) [Leishman stain (A) X400, (B) X1000].
autopsy-11-e2020196-gf01.jpg
PMC8101659_01_autopsy-11-e2020196-gf01.jpg
gf01
Analysis of the lymphoid morphology divulged two population of cells, the predominant (70% of lymphoid cells) being small atypical lymphocytes having round nuclei, clumped chromatin and scant cytoplasm, while the other sort (30% of lymphoid cells) constituted medium-sized cells (twice the size of a small lymphocyte) with a round to indented nucleus, moderately condensed nuclear chromatin, prominent central nucleolus and a moderate amount of cytoplasm (Figure 1A). The majority (68%) of these lymphoid cells were the medium-sized cells, while the remaining (32%) comprised the small atypical lymphocytes (Figure 1B).