PMC9969865_01
A skin color, semicircular nodule on the left side of the alar of the nose, with telangiectasis on the surface.
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Physical examination showed a clearly circumscribed semicircular nodule on the left side of the alar of her nose, 9 mm in diameter, skin color, moderate hardness, with smooth surface and telangiectasis, without ulcer and crust (see Figure 1).
The tumor composed of irregularly shaped lobules enmeshed in a dense fibrous stroma.
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Histologic examination showed normal epidermis (See Figure 2), there were several well-circumscribed irregular shaped nodules in the dermis, which were enmeshed in a dense fibrous stroma. There were prominent lymphoid cells infiltration around the nodules (see Figures 2 and 3).
The lobules had a peripheral rim of 1 or 2 layers of basaloid cells, central RS-L cells, and lymphocytes infiltration around. (Magnification x10).
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There were prominent lymphoid cells infiltration around the nodules (see Figures 2 and 3).
EMA-positive staining of the ductal structures. (Magnification x200).
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Immunohistochemical study showed cytokeratin and epithelial membrane antigen (EMA) were positive (see Figure 4), and carcinoma embryonic antigen (CEA) was negative.
T cells were the predominantly infiltrated cells in CL, T cell receptor marker CD3. (Magnification x200).
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The infiltration was composed of a mixture of T and B lymphocytes, with a predominance of T cells (see Figures 5 and 6).
B cell marker CD20. (Magnification x200).
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The infiltration was composed of a mixture of T and B lymphocytes, with a predominance of T cells (see Figures 5 and 6).
RS-L cell marker CD30. (Magnification x200).
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CD30+ cells (RS-L cells) (see Figure 7) are scattered in the center of the lobules, which may be representing activated lymphocytes and histiocytes.
CD1a positive staining of many intralobular dendritic cells. (Magnification x200).
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S100-positive dendritic cells were stained, and co-expressed CD1a (see Figures 8 and 9), possibly represent Langerhans cells.
S-100-positive staining of many intralobular dendritic cells. (Magnification x200).
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S100-positive dendritic cells were stained, and co-expressed CD1a (see Figures 8 and 9), possibly represent Langerhans cells.