PMC9173960_01
Auricular tumour node with an ulcerated surface that infiltrates the dermis while preserving cartilage (*) (a). Transition from differentiated component with smooth muscle morphology to osteosarcoma component (b).
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Macroscopic examination showed helix ear tissue with solid tumor mass measuring 1.9 x 1.7 cm, ulcerated surface (Figure 1(a)). Histologically, well-circumscribed dermal cellular nodule showed two different, sharply separated components (Figure 1(b)).
Spindle cell morphology of leiomyosarcoma (a) and dedifferentiated component of tumour characterized by pleomorphic, atypical cell producing osteoid (b) that was immunohistochemically completely negative for smooth muscle actin (SMA, as well as other muscle markers) (c).
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The other component consisted of atypical pleomorphic cells producing osteoid matrix in disorganized trabeculae with focal calcification, and osteoclastic giant cells were frequently scattered throughout the osteoid matrix (Figures 2(a) and 2(b)). Areas with leiomyosarcomatous appearance were strongly positive for alpha smooth muscle actin (Figure 2(c)) and vimentin, while focally positive for desmin and calponin, and negative for S-100.