PMC5299656_01
Key imaging and pathology results from the Rhabdomyosarcoma and Diffuse large B-cell lymphoma. a Axial view of the left thigh rhabdomyosarcoma demonstrating the lesion was FDG-avid on PET scan. b Morphology of rhabdomyosarcoma showing spindle cells in intersecting fascicles. (H&E, 200x) c Immunohistochemical stain for Desmin showing diffuse positivity supporting the diagnosis of rhabdomyosarcoma. d Axial view of the mediastinal diffuse large B-cell lymphoma demonstrating FDG-avidity on PET scan. e Morphology of lymph node showing involvement by diffuse large B-cell lymphoma. (H&E, 200x) f Higher power image of the lymphoma showing large lymphoid cells in sheets. (H&E, 400x)
40364_2017_86_Fig1_HTML.jpg
PMC5299656_01_40364_2017_86_Fig1_HTML.jpg
Fig1
Given the simultaneous occurrence of two rare and pathophysiologically distinct malignancies, each tumor was sequenced using MSK-IMPACT, a hybridization capture-based next-generation DNA sequencing assay of exons of 410 genes recurrently mutated in solid tumors (Fig. 1).