PMC5423895_01
Axial contrast-enhanced 3D-FAST SPIN ECHO spectral presaturation with inversion recovery [left: pre-whole-brain radiotherapy (WBRT); right: 9-month follow-up]: note decrease in intraparenchymal brain metastases and leptomeningeal enhancement pre- vs. post-WBRT. In addition, note consecutive enlargement of the lateral ventricles on 9-month follow-up scan.
fonc-07-00088-g001.jpg
PMC5423895_01_fonc-07-00088-g001.jpg
F1
Gadolinium-enhanced multiplanar MRI of the brain and spine showed isolated intraparenchymal and leptomeningeal carcinomatosis of the brain; the findings were conclusive for leptomeningeal spread (see Figures 1-3). Figures 1-3), contrast-enhanced MRI of the brain showed sustained durable response in the absence of any severe neurological side effects. Furthermore, follow-up 18F-FDG/PET-CT showed stable extracranial disease with multiple FDG non-avid sclerotic bone lesions as a sign of treatment response to afatinib.
Coronal contrast-enhanced T1-weighted magnetic resonance imaging [left: pre-whole-brain radiotherapy (WBRT); right: 9-month follow-up]: note decrease in leptomeningeal enhancement pre- vs. post-WBRT. In addition, note enlargement of the lateral ventricles on 9-month follow-up scan.
fonc-07-00088-g002.jpg
PMC5423895_01_fonc-07-00088-g002.jpg
F2
Gadolinium-enhanced multiplanar MRI of the brain and spine showed isolated intraparenchymal and leptomeningeal carcinomatosis of the brain; the findings were conclusive for leptomeningeal spread (see Figures 1-3). Figures 1-3), contrast-enhanced MRI of the brain showed sustained durable response in the absence of any severe neurological side effects. Furthermore, follow-up 18F-FDG/PET-CT showed stable extracranial disease with multiple FDG non-avid sclerotic bone lesions as a sign of treatment response to afatinib.
Sagittal contrast-enhanced 3D-FAST SPIN ECHO spectral presaturation with inversion recovery [left: pre-whole-brain radiotherapy (WBRT); right: 9-month follow-up]: note decrease in intraparenchymal brain metastases enhancement pre- vs. post-WBRT. In addition, note enlargement of the ventricles on 9-month follow-up scan.
fonc-07-00088-g003.jpg
PMC5423895_01_fonc-07-00088-g003.jpg
F3
Gadolinium-enhanced multiplanar MRI of the brain and spine showed isolated intraparenchymal and leptomeningeal carcinomatosis of the brain; the findings were conclusive for leptomeningeal spread (see Figures 1-3). Figures 1-3), contrast-enhanced MRI of the brain showed sustained durable response in the absence of any severe neurological side effects. Furthermore, follow-up 18F-FDG/PET-CT showed stable extracranial disease with multiple FDG non-avid sclerotic bone lesions as a sign of treatment response to afatinib.