PMC9251566_01
Bone marrow findings in CSF3R mutant MDS/MPN cases. The bone marrow biopsy of case 1 shows hypercellularity with myeloid predominant trilineage hematopoiesis with maturation (x400 magnification) (A) and a lymphoid aggregate (x400 magnification) (B). The bone marrow aspirate smear of case 1 shows myeloid hyperplasia with maturation and decreased erythroid elements with mild dyserythropoiesis (x1000 magnification) (C). The bone marrow biopsy of case 2 shows hypercellularity with erythroid predominant trilineage hematopoiesis, dysplastic megakaryocytes, increased macrophages, and one small granuloma (x400 magnification) (D). The bone marrow aspirate smear of case 2 shows erythroid predominance, dyserythropoiesis, occasional macrophages with hemophagocytosis, and ring sideroblasts (inset) (x600 magnification) (E). The bone marrow biopsy of case 3 shows hypercellularity with myeloid predominant trilineage hematopoiesis with maturation, megakaryocytosis with dysplasia, and increased fibrosis (F). The trends of basic complete blood count parameters during the clinical course of patient 1 (G).
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She eventually developed significant leukocytosis (56.2 x 109/L at peak) and thrombocytosis (752 x 109/L at peak) (Fig. 1G).