PMC4130425_01
Time course of patient treatment and therapeutic drug monitoring results. Time course of (A) voriconazole i. v. dosage administration, (B) comedication with esomeprazole or ranitidine and (C) associated antiretroviral therapy. Voriconazole plasma trough concentrations. qd: once a day; b.i.d.: Twice a day.
1742-6405-11-25-1.jpg
PMC4130425_01_1742-6405-11-25-1.jpg
F1
Voriconazole first C0 was subtherapeutic (<1.0 mug/mL; range 1.0 - 5.0 mug/mL ) (Figure  1). Several voriconazole C0 were then measured below the therapeutic range despite substantial increased dosing (Figure  1).