PMC6591315_01
The effect of reserpine withdrawal on striatal DAT availability. Parametric images of striatal dopamine transporter (DAT) availability acquired using DAT-SPECT with [123I]FP-CIT. Images show the distribution volume ratio (DVR), which was used as a measure of DAT availability. The mild and homogenous decrease in DAT availability at initial presentation (01/2018) was completely resolved at follow-up (04/2018), 3 months after the withdrawal of reserpine. Images were acquired on a dual-headed SPECT system, 3 h after intravenous injection of 185 MBq [123I]FP-CIT.
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F1
DAT SPECT showed a mild but remarkable bilateral homogenous reduction of DAT availability in the striatum (Figure 1; approximated striatal binding potential, BP: right 1.72, left, 1.89, lower normal cut-off: 2.1), without the anterior-posterior gradient with strong putaminal involvement that is typical for PD. After 3 months, this tremor had also disappeared and a follow-up DAT SPECT scan had normalized completely (Figure 1; striatal BP: right, 2.22; left, 2.34).