PMC5436014_01
Preoperative neuroimaging of the patient showing an infiltrating right fronto-temporo-insular tumor with irregular contrast enhancement.
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Neuroimaging studies demonstrated an irregular space-occupying process consistent with a malignant glioma in the right fronto-temporo-insular region (Fig. 1).
Intraoperative view of the patient's cerebral surface with the naked eye (a), under blue light exposure (b), and by using IRT brain mapping (c).
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After the dura opening, the cerebral surface appeared seemingly normal (Fig. 2a). However, the ultraviolet light exposure revealed a moderate fluorescence in the region of the Silvian fissure (Fig. 2b), and the IRT observation demonstrated a significantly colder area (Deltat  1.01 C) in the limited field of the middle frontal gyrus, well corresponding to the epicenter of the lesion (Fig. 2c).
Conventional histological analysis of the lesion revealing prominent cellular polymorphism, microvascular proliferation, and pseudopalisading necroses. HE. x100.
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A partial excision of the lesion was performed, and the histological result was GBM (Fig. 3).