PMC2671152_01
T2-weighted scans from S at age 5, shortly after completion of radiation therapy (slices are approximately Z=0 through Z=60). The cystic lesions had not formed by this time, but regions of white matter damage are evident (white arrows).
nihms89389f1.jpg
PMC2671152_01_nihms89389f1.jpg
F1
White matter damage following radiation therapy was initially progressive, as was the development of large cystic regions in the left frontal and parietal lobes (compare Figures 1 and 2).
Axial slices (Z=20, 25, 30 and 35) showing T2-weighted (A, B), mean diffusivity (C, D) and fractional anisotropy (E, F) for S (A, C, E) and a 12 year old female control subject (B, D, F). The two large cystic lesions in the left hemisphere are evident in A and C (arrows). Diffusely increased mean diffusivity (MD) and reduced fractional anisotropy (FA) are evident in panels C and E, respectively.
nihms89389f2.jpg
PMC2671152_01_nihms89389f2.jpg
F2
White matter damage following radiation therapy was initially progressive, as was the development of large cystic regions in the left frontal and parietal lobes (compare Figures 1 and 2).