PMC8432357_01
PMC8432357_02
A - Medium sized blood vessel, Kidney (H&E, 440x); B - CD20 immunostaining, Kidney (440x) demonstrating malignant lymphoid infiltrate which stains positive for CD20.
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Examination of multiple organs did show malignant lymphoid cells with enlarged round or oval nuclei with prominent chromatin and occasional nucleoli and scant cytoplasm within the vascular spaces (Figure 1A). These malignant cells did stain positive for CD20 (Figure 1B), and were found in vasculature of the brain, heart, lungs, liver, spleen, kidneys, thyroid, peri-adrenal adipose, prostate, and testes.
A - Liver with lymphocytic infiltrate (H&E, 440x); B - CD20 immunostaining, Liver (440x) demonstrating malignant lymphoid infiltrate which stains positive for CD20.
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CD20 (Figure 2) and negative for CD3 and CD34. Cervical lymph nodes sampled did not contain malignant cells.