PMC4327552_01
Clinical appearance and histological findings. a Solitary, red-brown, well-demarcated plaque on the abdomen. b, c Nodular infiltration of large cells with eosinophilic ground-glass cytoplasm accompanied by scattered lymphocytes in the superficial and middle dermis (b: lower magnification, c: higher magnification). d The large epithelioid histiocytes in the dermis were positive for CD68.
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F1
The skin lesion exhibited a well-demarcated brown-red plaque measuring 15 x 10 mm (fig. 1a). Skin biopsy revealed nodular infiltration of large cells with an abundant eosinophilic ground-glass cytoplasm between collagen bundles in the superficial, partially vaguely nodular appearance (fig. 1b). Nuclei were generally vesicular with a single nucleolus and without atypia, but some were binucleated or multinucleated (fig. 1c). Immunohistochemical staining of the large cells was positive for CD68 (fig. 1d), but negative for S-100 protein and CD1a (data not shown).