PMC9610126_01
Preoperative magnetic resonance imaging (MRI) scans of Patient No. 1 with neurofibromatosis type 2: (a) Axial T2-weigthed MRI with contrast shows a meningioma 23 x 15 x 8 mm in size at the C1-2 level. The tumor adheres to the posterior-lateral side of the spinal canal. The meningioma presses and displaces the spinal cord. (b) Sagittal T2-weigthed MRI with contrast shows the meningioma and coexisting intraspinal ependymoma sized 11 x 9 x 5 mm at the C2 level. (c) Coronal T1-weigthed MRI with contrast shows the meningioma before surgery.
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F1
In the center of the spinal cord, the tumor was located at the C2 level [Figure 1].
PMC9610126_02
Pre- and post-operative imaging of patient No. 2: (a) Pre-operative sagittal T2-weigthed thoracic MRI of a 10-year-old girl. A small meningioma 7 x 5 x 8 mm at the Th11 level. (b) Sagittal T2-weigthed cervicothoracic junction MRI exposes a massive meningioma 24 x 11 x 15.5 mm at the Th3-Th4 level. The tumor presses and displaces the spinal cord. (c) Post-operative control sagittal T2-weigthed cervical and thoracic MRI. A post-operative reaction at the Th11 level. At the Th3/Th4 level, MRI shows a postoperative reaction or tumor residual mass. A MRI control scan was performed 6 months after the primary surgery.
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F2
Thoracic MRI showed a small tumor 7 x 5 x 8 mm in size at the Th11 level [Figure 2a]. Th3/Th4 level [Figure 2b]. The tumor significantly compressed and displaced the spinal cord. After total gross tumor resection, regression of lower limbs paresis was observed [Figure 2c].
MRI scan performed after 3-year follow-up of Patient No. 2: (a) Sagittal T2-weigthed thoracic MRI shows multiple small meningiomas at the Th2, Th5, Th8, Th9, Th11, Th12/L1 levels, and a tumor at the Th3-Th4 level sized 17 x 7 x 27 mm causing spinal cord compression. (b) Sagittal T2-weigthed cervical MRI presents tumors at the C2-3 and C6-7 levels with spinal cord compression. (c) Axial T2-weighed cervical MRI shows bilateral vestibular schwannomas.
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F3
Control thoracic MRI showed multiple meningiomas at the Th2 to L1 level [Figure 3a]. Cervical MRI demonstrated a pathological mass at C2-C3 and at C6-C7 level with spinal cord compression [Figure 3b]. Bilateral vestibular schwannomas were also detected on the MRI scan [Figure 3c].
PMC9610126_03