PMC5784750_01
Clinical course and results of immunohistochemistry, imaging, and pathology analyses.. Notes: (A) Timeline of examination and therapy. Black arrow heads indicate pelvic CT scans and immunohistochemical analyses at 3-month intervals for 9 months. (B) Temporal profile of immunohistochemical analysis of the patient's CSF. Robust reactivity in the hippocampus was observed on admission. This reactivity remained after the first operation and the immunotherapy (after 3 and 6 months). Note that no reactivity was confirmed after the second operation (after 9 months). Scale bar: 200 mum. (C) Pelvic CT scan images. Bilateral ovarian teratomas on admission (yellow arrows) were enucleated in the first operation. Six months later, recurrence of the left ovarian teratoma could be seen (yellow arrow). The bilateral ovaries were completely resected by salpingo-oophorectomy (second operation; after 9 months). Scale bar: 5 cm. (D) Pathological findings. In addition to the left ovary, the pathological examination of the right ovary showed a mature cystic teratoma, indicating bilateral recurrence of the ovarian teratomas. Yellow arrows show neuroglial tissues. Scale bar: 100 mum.. Abbreviations: CSF, cerebrospinal fluid; CT, computed tomography; m, months.
ndt-14-339Fig1.jpg
PMC5784750_01_ndt-14-339Fig1.jpg
f1-ndt-14-339
The timeline of the examination and therapy is shown in Figure 1A. Although her pelvic CT at 3 months after the first operation showed no signs of tumor, another pelvic CT at 6 months indicated significant recurrence of a left-sided ovarian teratoma (Figure 1C). Concurrent immunohistochemical CSF analyses revealed persistently high reactivity of NMDAR antibody (Figure 1B). The pathological results showed recurrent mature cystic teratomas on the ovaries from both sides (Figure 1D).