PMC6245346_01
Microscopic view of the bone marrow aspirate.. Notes: The upper picture shows a severe dysgranulopoiesis, characterized by a maturation stop after meta-/myelocyte stage, before starting filgrastim. The lower picture shows a normal bone marrow of our patient 2 weeks after terminating filgrastim.
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B19], Rubella, cytomegalovirus, and herpes infections, [para] influenza, respiratory syncytial virus, adenovirus) could be demonstrated. Testing for antineutrophil antibodies was not done, as the tests often show false-positive and false-negative results. Bone marrow aspiration revealed a severe dysgranulopoiesis, characterized by a maturation stop after meta-/myelocyte stage (Figure 1), indicating severe congenital neutropenia. Two weeks after terminating, the filgrastim a new bone marrow aspiration (Figure 1) and a complete blood count was repeated.
ANC (cells/microL) of the patient (the arrows symbolize the start and the terminating of filgrastim) over several months.. Abbreviation: ANC, absolute neutrophil count.
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Two months after birth, filgrastim was terminated which, initially, led to a decrease of ANC, before it stabilized in the normal range (Figure 2).