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Incidence of nosocomial Clostridium difficile infection.. Notes: The overall incidence of nosocomial C. difficile infection is shown by year (blue), as is the incidence according to patient age (black). From N Engl J Med, Leffler DA, Lamont JT, Clostridium difficile infection, 372(16):1539-1548. Copyright   (2015) Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
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Another study found that US rates of hospital discharges with CDI increased from ~5 per 1,000 discharges in 2,000 to greater than 10 per 1,000 discharges in 2008; increases were especially prominent among those >=65 years of age (Figure 1).
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