PMC6016583_01
Imaging and histological findings of spinal hemangioblastoma during puerperium.. Notes: (A, B) MRI presentation of the tumor in the immediate postpartum period. (A) Contrast-enhanced T1-weighted sagittal section showing a hyperintense solid nodule at D11-D12 (white arrow). Tumor volume of 1.7 cm3. (B) T2-weighted sagittal section showing bulbocervical edema (*) and extensive hydrosyringomyelia (dotted white arrow). (C, D) MRI presentation of the tumor after 55 days. (C) Reduction in tumor size (tumor volume of 1.0 cm3) but showing the same image characteristics: intense contrast enhancement (solid white arrow). (D) Same caudal and cranial hydrosyringomyelia at C3 (dotted white arrows) but complete disappearance of medullary edema (#). (E) Histopathology (H&E) showing vascular proliferation surrounded by stromal cells with clear nuclei, a characteristic feature of hemangioblastoma (total magnification: 400x). (F) Immunohistochemical staining that was positive for inhibin in stromal cells and negative for estrogen and progesterone receptors (the positivity for estrogen and progesterone receptors would be demonstrated by brown staining in the cell nuclei; total magnification: 400x).. Abbreviation: MRI, magnetic resonance imaging.
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Contrast-enhanced magnetic resonance imaging (MRI) performed on the fifth postpartum day showed a tumor suggestive of hemangioblastoma in the thoracic spine (T11-T12), accompanied by hydrosyringomyelia and edema from C4 to the bulbopontine transition (Figure 1A and B). Imaging control performed 55 days later showed a reduction in the size of the tumor and complete remission of bulbomedullary edema (Figure 1C and D). Histopathological analysis confirmed the diagnosis of hemangioblastoma (Figure 1E), and immunohistochemistry was negative for estrogen and progesterone receptors (Figure 1F).