PMC4173311_01
MRI on admission (5 months before death). MRI on admission (a and b) transversal and sagittal Flair sequence; (c) Sagittal T2-weighted sequence. Demonstration of a hyperintense lesion extending on both side of the pons (arrow), predominantly on the left side beneath the red nuclei up to the right sided mesencephalon along the third ventricle
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F1
MRI (Flair and T2-weighted sequences) showed a hyperintense lesion extending from the postero-lateral left portion of mesencephalon. Most characteristic sequences are shown in Figure 1.
Microscopical findings within the biopsy specimen. (a) hematoxylin and eosin staining: Enlarged dark nuclei of oligodendroglial cells. (b) immunhistochemical staining with immunoperoxidase: Detection of JC virus antigen within these nuclei (visualized as dark brown nuclei)
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F2
The biopsy specimen [Figure 2] showed brain tissue with reactive astrocytosis, a few lipid-filled macrophages, a venule with some perivascular lymphocytes, and dark nuclei of glial cells.