PMC5684422_01
On cystourethroscopy: A black colored lesion partially occluding the distal third of the urethra.
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On cystourethroscopy, it was evident that the lesion partially occluded the distal third of the urethra (Fig. 1).
On light microscopy: the large epitheloid tumor cells have dusty brown melanin pigments and frequent mitotic figures (H&E, x400).
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Most of the tumor cells contained coarsely granular melanocytic pigment (Fig. 2).
On IHC: The tumor cells were immunoreactive for HMB-45(A) and S-100 protein(B).
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Immunohistochemically tumor cells showed strong cytoplasmatic reactivity for HMB45 and S100 (Fig. 3A and B).