PMC6827600_01
MRI images showing endocranial mycotic abscess at day 41 and the result at the end of treatment with ISC, day 359.
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A new MRI, at day +41, revealed the presence of a brain mycotic abscess with associated vasogenic cerebral edema of the right temporal lobe (Figure 1). At six months from HSCT, a new MRI of the brain showed the reduction of the para-cavernous abscess with partial reabsorption of the purulent quote and temporal lobe edema (Figure 1).
TDM of ISC during one year of treatment showing an increment of plasma concentrations in correspondence with the improvement of intestinal GvHD (all blood samples were collected 12 hours after the last administration of the drug).
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ISC dosage was increased to 300 mg/die in consideration of ISC plasma concentrations (Figure 2); deferasirox was reintroduced in therapy.