PMC5925958_01
Flow - volume loop of pulmonary function test.
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FEV1/FVC - 76%, % FEV1 - 74%, % FVC - 97%, % FEF25-75 - 38%, % FEF50 - 40%, % FEF75 - 31%, % PEFR - 74%. Flow - volume loop has been shown in Fig. 1.
Axial High Resolution CT of Thorax (Lung Window) showing a nodular opacity with foci of calcification within the lumen of left upper lobe bronchus along with adjacent bronchial wall thickening (white arrow).
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As there was persistent rhonchi and shortness of breath despite optimal treatment for asthma exacerbation, CT chest was done which revealed left upper lobe bronchial wall thickening and calcification with moderate stenosis (Fig. 2).
Fiberoptic bronchoscopy showing yellowish color, nodular tumor like lesion in left upper lobe bronchus.
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In view of CT chest findings, fiberoptic bronchoscopy was done which showed yellowish color, nodular tumor like lesion in left upper lobe bronchus (Fig. 3).
Section shows bronchial mucosa with extra cellular deposition of amorphous pink material (H&E, 10x).
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Biopsy of the lesion revealed benign bronchial mucosa and underlying stoma with pink amorphous material deposits showing orange red by congo red stain and green birefringence under polarized light, suggesting amyloidosis (Fig. 4, Fig. 5).