PMC5726704_01
Previous treatments with hydrocortisone acetate cream 1% and hydroquinone
cream 3% for one year, with no improvement. She denied respiratory or
ocular symptoms. Physical examination revealed well-defined
yellowish-brown infiltrated plaques located in the inner third of the
eyebrows
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f1
She had a permanent makeup cosmetic tattoo 16 years before the onset of lesions (Figure 1).
A. Dense granulomatous infiltrate involving the entire
dermis with presence of pigmented granules in the papillary dermis.
Hematoxylin & eosin, X10. B. Epithelioid granulomas
surrounded by lymphocytic infiltrates with black pigment in the central
portion. Hematoxylin & eosin, X40
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f2
Histopathological examination of one of the lesions showed thick dermis with lymphocytic infiltrates around epithelioid granulomas involving the entire dermis, with presence of black pigment in the central portion (Figure 2).
PMC5726704_02
Physical examination showed areas of tattoos on his forearms, right thigh
and foot with numerous salmon-colored papules and plaques with discrete
scaling at the periphery
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f3
The second case was a 20-year-old man, tattoo artist, who reported the onset of painful lesions on 3 tattoos made one year and a half earlier (Figure 3).
A. Epithelioid granulomas with central black pigment
involving the entire dermis with mild inflammatory infiltrate.
Hematoxylin & eosin, X10. B. Epithelioid granuloma.
Hematoxylin & eosin, X10
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f4
Histopathology revealed a sarcoidal granulomatous reaction (Figure 4).