PMC6766119_01
Cutaneous mass of the right thigh.
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fig1
An 11-day-old male was referred for evaluation of a cutaneous mass of the right upper lateral thigh (Figure 1).
Excision of mass and primary closure.
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Primary closure was performed after undermining with recruitment of local tissue (Figure 2).
Histopathology with hematoxylin and eosin staining. Scanning view (1x magnification) shows a dermal proliferation of spindled cells with lighter and darker areas.
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The final pathology revealed the diagnosis of infantile myofibroma (Figures 3-7).
Low power view (5x magnification) shows a nodular/multinodular tumor with a zonal appearance of hypercellular areas in the center and hypocellular areas at the periphery.
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fig4
The final pathology revealed the diagnosis of infantile myofibroma (Figures 3-7).
Higher power view (10x magnification) shows a multinodular, biphasic tumor with alternating hyper and hypocellular areas.
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The final pathology revealed the diagnosis of infantile myofibroma (Figures 3-7).
High-power view (20x magnification) shows numerous hemangiopericytoid slit-like vessels in the center of the tumor.
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The final pathology revealed the diagnosis of infantile myofibroma (Figures 3-7).
Staining for smooth muscle actin shows that myofibroblastic areas (myoid component) are positive while the fibroblastic areas (nonmyoid areas) are negative (10x magnification).
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fig7
The final pathology revealed the diagnosis of infantile myofibroma (Figures 3-7).