PMC5228656_01
(A-D) Axial CT images demonstrated multiple calcifications within bilateral thalamus, basal ganglia, subcortical white matter of parietal, temporal and occipital lobe, and dentate nucleus of cerebellum, an intraparenchymal cyst in the left temporo-parietal region and widespread low-density area of the cerebral white matter. (E-P) MRI of the brain was performed using a 1.5T scanner (Signa EXCITE, GE Medical Systems, Pewaukee, WI) with the following sequences: T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), fluid-attenuated inversion recovery image (FLAIR), diffusion-weighted image (DWI), and gradient-echo imaging (T2*WI). (E-H)T1WI (repetition time/echo time (TR/TE), 1538.8/9.128 ms; field of view (FOV), 24 cm; and matrix size, 32 x 32) and T2WI (TR/TE, 3620/88.884 ms; FOV, 24 cm; and matrix size, 32 x 32) showed multiple cysts in the left temporo-occipital lobe, right temporal lobe, and right occipital lobe. (I-K) FLAIR (TR/TE, 8002/166.132 ms; FOV, 24 cm; and matrix size, 32 x 32) images depicted the diffuse hyperintense area in cerebral white matter. In addition, some abnormalities, which were suggestive of calcifications and cysts, could also be observed. (M, N) T2*WI (TR/TE, 300/20 ms; FOV, 24 cm; and matrix size, 32 x 32) revealed several hypointense regions within the thalamus, basal ganglia, subcortical white matter in bilateral parietal, temporal and occipital lobes representing calcifications (in combination with A-D) and micro hemorrhages (white arrow). (O-P) Single-voxel proton magnetic resonance spectroscopy analysis (H1-MRS, TR/TE, 1500/35 mms; FOV, 24 cm; matrix size, 32 x 32; and 14.4 cm3 voxel size) on the left basal ganglia revealed a normal spectrum. DWI = diffusion-weighted image, FLAIR = fluid-attenuated inversion recovery image, FOV = field of view, H1-MRS = proton magnetic resonance spectroscopy, MRI = magnetic resonance imaging.
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Neuroimaging including cranial computed tomography (CT) and magnetic resonance images (MRI) revealed a variety of intracranial calcifications which involved the thalamus, basal ganglia, parietal lobe, temporal lobe, occipital lobe, and cerebellum (Fig. 1A-D), 3 parenchymal cysts located in the left temporo-occipital lobe, right temporal lobe, and right occipital lobe, respectively (Fig. 1E-H), diffuse hyperintense region in cerebral white matter (Fig. 1I-L), and micro hemorrhages within the left temporal lobe and right occipital lobe (Fig. 1M and N). Single-voxel proton magnetic resonance spectroscopy (H1-MRS) analysis on the left basal ganglia revealed a normal spectrum (Fig. 1O and P).