PMC5751031_01
Centrizonal parenchyma demonstrating severe cholestasis with formation of cholestatic rosettes, mild lymphocytic inflammation, reactive changes in hepatocytes, and an acidophil body (apoptotic hepatocyte). Hematoxylin and eosin stain, 400x overall magnification.
omx077f01.jpg
PMC5751031_01_omx077f01.jpg
omx077F1
A percutaneous liver biopsy was performed showing severe cholestasis with bile duct injury/inflammation and hepatocyte injury without steatosis (Fig. 1), consistent with DILI.