PMC8655243_01
Pre- and postoperative imaging of the child. Preoperative MRI showed hypo- and isointensity mixed signal, together with focal hyperintensity on T1WI (A) and T2-weighted FlAIR (B). The lesion is iso- and hyperintensity mixing signals and well-circumscribed on axial T2WI (C). Post-contrast T1WI showed moderate heterogeneous contrast enhancement of the lesion (D-F). Follow-up MRI at 29-month after surgery revealed that the lesion was completely removed with no signs of recurrence (G-I).
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Magnetic resonance imaging (MRI;  Figure 1 ) revealed a large, irregular, heterogeneous mass of approximately 4.9x5.4x6.2 cm, which herniated to the orientation of the foramen magnum, extending to the C2 level. Iso- and hypointensity signals were seen on T1-weighted imaging (T1WI;  Figure 1A ) and T2-weighted fluid attenuated inversion recovery (FLAIR;  Figure 1B ). Mixing isointensity and hyperintensity signals were seen on T2-weighted imaging (T2WI;  Figure 1C ). On enhancement, the tumor showed moderate heterogeneous enhancement with an ill-defined boundary ( Figures 1D-F ). Postoperative MRI of brain and the whole spinal cord together with the periodical cranial MRI examinations demonstrated that the lesion had been completely removed, with no signs of recurrence or metastasis ( Figures 1G-I ).
Histopathology of the cerebellar liponeurocytoma. Hematoxylin and eosin-staining showing that a large number of small round tumor cells with low mitotic activity grow in sheets, and clusters of fat cells (A) and that chrysanthemum clusters (B) are seen among the cells. Immunohistochemical examination presented a Ki-67 index of 5% grossly, and 10-20% focally (C).
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These tumor cells grew in a sheet shape with clusters of fat cells were observed in the center ( Figure 2A ) or formed chrysanthemum-liking clusters ( Figure 2B ). Immunohistochemical analysis indicated that the Ki-67 index was +- 5% mostly, and only 10-20% focally ( Figure 2C ).