PMC1201178_01
Sonographic examination: 15 mm hypoechoic solid, non-calcified circumscribed mass, with a thin echoic rim, benign in appearance, located in subcutaneous fat at 9 o'clock in the left breast.
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F1
SCM, did not show any obvious abnormality. Sonographic examination revealed a 1.5 cm in size, hypoechoic, solid, non-calcified, circumscribed mass, grossly ovoid with a thin echoic rim, located in the subcutaneous fat at 9 o'clock in the left breast (Figure 1).
photomicrograph 2A) Invasive ductal carcinoma, apocrine type: tumor exhibits an irregular invasive border and forms glandular structures. Hematoxylin and eosin stain, original magnification x 40. 2B) Invasive ductal carcinoma, apocrine type: cytological characteristics of intermediate nuclear grade, prominent nucleoli, and eosinophilic granular cytoplasm. Hematoxylin and eosin stain, original magnification x 100.
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F2
An infiltrating ductal carcinoma, apocrine type, grade 2 of 3 of modified Bloom and Richardson, with associated ductal carcinoma in situ, cribriform type, nuclear grade 2 of 3, occupying 10% of tumor mass (Figures 2A and 2B) was identified.
PMC1201178_02
Pedigree of the family with germline BRCA2: 6503delTT mutation. All individuals affected with cancer (ca) are depicted by filled-in symbols. Individual ID numbers, age at the time of diagnosis (dx) and/or death are below each symbol.
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F3
French Canadian population. Family history (Figure 3) was significant for breast cancer in proband's father (II-6) who was diagnosed at the age of 77 and mother (II-7) diagnosed at 79.