PMC4776232_01
Lymphoepithelioma-like carcinoma: solid nests of tumor cells with dense lymphocytic infiltration (hematoxylin and eosin stain; original magnification x400).
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On pathologic examination, the tumor cells had irregular vesicular nuclei, prominent nucleoli and indistinct cytoplasmic borders with high nuclear/cytoplasmic ratio (Fig. 1).
Strong nuclear staining with ERG in lymphoepithelioma-like carcinoma (immunohistochemical stain; original magnification x400).
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ERG and NKX3.1 (Figure 2, Figure 3), epithelial marker CKAE1/3 and negative for prostatic carcinoma markers (PSA, p504S) and urothelial carcinoma marker (p63 and GATA3). EBV-encoded RNA (EBRE) was not identified by chromogenic in situ hybridization (CISH).
Strong nuclear staining with NKX3.1 in lymphoepithelioma-like carcinoma (immunohistochemical stain; original magnification x400).
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ERG and NKX3.1 (Figure 2, Figure 3), epithelial marker CKAE1/3 and negative for prostatic carcinoma markers (PSA, p504S) and urothelial carcinoma marker (p63 and GATA3). EBV-encoded RNA (EBRE) was not identified by chromogenic in situ hybridization (CISH).