PMC9047788_01
(a) Solitary lesion of GF with ulcer on the central forehead. (b) Lesion of GF after
successful treatment of the ulcer with a combination of intralesional triamcinolone and
pimecrolimus cream.
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III skin. In the glabellar region, there was a solitary 7 cmx5 cm brown-purple, shiny, bossellated, annular, firm plaque with large overlying telangiectasias (Figure 1(a)). The ulcer healed and the lesion continues to flatten and lighten gradually but is still present (Figure 1(b)).
(a) A diffuse dermal infiltrate extends into the deep dermis, occasionally accompanying
adnexal structures. A grenz zone is present. Note the superficial dilated lymphatics
(10x magnification, H&E stain). (b) Higher magnification reveals a mixed population
of plasma cells, neutrophils, eosinophils, lymphocytes, and histiocytes. Most vessels
are dilated and are lined by plump endothelial cells (200x magnification, H&E
stain).
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Skin biopsy showed inflammation involving the entire dermis composed of lymphocytes, plasma cells, histiocytes, neutrophils, and eosinophils (Figure 2).