PMC8348153_01
Computed tomography scans showed bilateral diffuse nodules and areas of parenchymal consolidations (A,B). Follow-up computed tomography scan after 10 years observation showed progression and evolvement of the bilateral multiple consolidations and nodules (C). Consolidations and nodules are calcified (D).
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Multiple calcifications were to observe. (Fig. 1 C,D).
PMC8348153_02
Computed tomography scan showing multiple lung and subpleural nodules in a perilymphatic distribution in both upper lobes.
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Chest CT (Fig. 2.) showed bilateral hilar, axillary and epigastric lymphadenopathy, multiple lung and subpleural nodules in a perilymphatic distribution with predominance to both upper and middle lobe.
PMC8348153_03
Computed tomography scan showing a tumour with 44 mm in maximal diameter in the right lung.
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Control chest CT revealed mild progression of the disease with maximal diameter of the nodule to 44 mm (Fig. 3.).
PMC8348153_04
Computed tomography scan showing a tumour in 3rd segment of the right lung (A) with diffuse subpleural traction bronchiectasis and honeycombing (UIP pattern) (B). Microscopic examination of the tissue specimen with hematoxylin and eosin staining under low magnification showing diffuse pulmonary amyloidosis. A fragment of lung parenchyma with amorphouseosinophilic material.Inflammatory infiltrates composed of lymphocytes and plasma cells are visible around the amyloid deposits (C). Congo red staining under low magnification showed amyloid deposits (D). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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High resolution computer tomography (HRCT) performed in 2013 revealed signs of usual interstitial pneumonia (UIP) (Fig. 4B) accompanied by irregular subpleural consolidations in both lungs, extending to maximal 18 mm in diameter. As malignancy was suspected, 18-F- fluorodeoxyglucose (FDG) positron emission tomography (PET-CT) was conducted and characterized one nodule in 3rd segment of the right lung as suggestive of malignancy (Fig. 4A). Deposits showed positivity to Congo red staining and green birefringence to polarized light (Fig. 4C and D).