PMC6052933_01
Bronchofibroscopic biopsy revealed SCC with opening of right upper lobar bronchus (A), and TBNA found cancer cells in 4R (B) and 7 lymph node groups (C).. Abbreviations: SCC, squamous cell carcinoma; TBNA, transbronchial needle aspiration.
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Pathologic results of bronchofibroscopic biopsy revealed lung SCC with right hilar and mediastinal lymph nodes metastases (Figure 1).
Chest CT images.. Notes: (A and B) the images shows after radiotheray and icotinib, that the right lung primary lesion and mediastinal lymph node were enlarged, and the disease had progressed in March 2016; (C) the image shows tumor shrinkage in May 2016; (D) the image reveals a large cavity in the lung tumor and minimal change in tumor size, in July 2016; (E) the image shows a mass in the right lung hilum and mediastinum, and disease progression once more in October 2017.. Abbreviation: CT, computed tomography.
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Unfortunately, in March 2016, after 8 months of icotinib therapy, the disease progressed again (Figure 2A and B). Imaging examination showed tumor shrinkage after 2 months of apatinib administration (Figure 2C). Moreover, about 4 months later, chest CT scan revealed a large cavity of 2.9x1.6 cm in the lung tumor, with minimal change in tumor size (Figure 2D). The latest chest CT scan on October 2017 showed a mass in the right lung hilum and mediastinum, so the disease had progressed once more (Figure 2E).