PMC5909947_01
Multiple liver nodules, with hypoechoic rim (halo sign).
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F1
The abdominal ultrasound we performed confirmed these findings (Figures 1, 2). 
Hypervascular liver metastases.
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F2
The abdominal ultrasound we performed confirmed these findings (Figures 1, 2). 
Hematoxylin and eosin staining. Atypical small cell proliferation.
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F3
The histopathological examination described atypical small and monomorphic cell proliferation, with round nuclei, without obvious nucleolus, with eosinophilic cytoplasm; compact cellular placement, frequently around neoformed capillaries resulting in microacinar structures (Figures 3, 4). 
Monomorphic cells, with round nuclei and eosinophilic cytoplasm.
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F4
The histopathological examination described atypical small and monomorphic cell proliferation, with round nuclei, without obvious nucleolus, with eosinophilic cytoplasm; compact cellular placement, frequently around neoformed capillaries resulting in microacinar structures (Figures 3, 4). 
IHC positive for chromogranin A
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F5
 Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).
IHC positive for synaptophysin
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F6
 Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).
IHC positive for synaptophysin - detail
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F7
 Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).
IHC for Ki67+ (10-15%)
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F8
 Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).