PMC5943118_01
A: Primary cardiac fibroblastic osteosarcoma with well-differentiated osteosarcoma infiltrating the left atrium (HE, x4 magnification). B: Primary cardiac fibroblastic osteosarcoma with osseous matrix, osteoid matrix embedded pleomorphic tumor cells (HE, x20 magnification). C: Spindle cells with a solid growth pattern of pleomorphic and spindle cells with prominent nuclear atypia (HE, x10 magnification).
medi-97-e9543-g001.jpg
PMC5943118_01_medi-97-e9543-g001.jpg
F1
Primary, cardiac fibroblastic osteosarcoma had the typical appearance of interlacing hyperchromatic spindle-shaped stromal cells associated with osseous matrix (Fig. 1A). Osteoclastic-like, giant cells were scattered throughout without foci of hemorrhage and necrosis (Fig. 1B). Tumor cells were pleomorphic with spindle-shaped nuclei and hyperchromatin (Fig. 1C).