PMC8762331_01
Brain magnetic resonance imaging (MRI) findings in patients 1 and 2. Patient 1 (A-C) On admission, FLAIR hyperintensity was seen in the leptomeningeal of bilateral frontal lobe and parietal lobe in patient 1 (A) (arrowhead); repeat brain MRI FLAIR result returned to normal at discharge and 8 months after discharge (B,C). Patient 2 (D-G) Brain MRI results showed T2 FLAIR and DWI hyperintensity (D,E) (arrowhead) with swelling of brain tissue and narrowing of sulcus; the swelling of brain tissue was alleviated, and hyperintensity of FLAIR and DWI was improved after immunotherapy (F,G) (arrowhead); brain MRI normalized at 1 month after discharge (H).
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PMC8762331_02_fnhum-15-782490-g001.jpg
F1
Brain MRI results showed FLAIR (Figure 1D) hyperintensity and diffusion-weighted images (DWI; Figure 1E) showed diffusion restriction in the right temporal lobe, parietal lobe, and occipital lobe without enhancement (Supplementary Figure 2, clinical evolution of the patient 2). Repeat brain MRI results showed lower hyperintensity of FLAIR (Figure 1F) and DWI (Figure 1G) than before. During the follow-up, repeated brain MRI normalised at 1 month without relapse (Figure 1H).
PMC8762331_02
Brain magnetic resonance imaging (MRI) findings in patients 1 and 2. Patient 1 (A-C) On admission, FLAIR hyperintensity was seen in the leptomeningeal of bilateral frontal lobe and parietal lobe in patient 1 (A) (arrowhead); repeat brain MRI FLAIR result returned to normal at discharge and 8 months after discharge (B,C). Patient 2 (D-G) Brain MRI results showed T2 FLAIR and DWI hyperintensity (D,E) (arrowhead) with swelling of brain tissue and narrowing of sulcus; the swelling of brain tissue was alleviated, and hyperintensity of FLAIR and DWI was improved after immunotherapy (F,G) (arrowhead); brain MRI normalized at 1 month after discharge (H).
fnhum-15-782490-g001.jpg
PMC8762331_02_fnhum-15-782490-g001.jpg
F1
Brain MRI results showed FLAIR (Figure 1D) hyperintensity and diffusion-weighted images (DWI; Figure 1E) showed diffusion restriction in the right temporal lobe, parietal lobe, and occipital lobe without enhancement (Supplementary Figure 2, clinical evolution of the patient 2). Repeat brain MRI results showed lower hyperintensity of FLAIR (Figure 1F) and DWI (Figure 1G) than before. During the follow-up, repeated brain MRI normalised at 1 month without relapse (Figure 1H).
Review flow-chart.
fnhum-15-782490-g002.jpg
PMC8762331_02_fnhum-15-782490-g002.jpg
F2
Brain MRI results showed FLAIR (Figure 1D) hyperintensity and diffusion-weighted images (DWI; Figure 1E) showed diffusion restriction in the right temporal lobe, parietal lobe, and occipital lobe without enhancement (Supplementary Figure 2, clinical evolution of the patient 2).