PMC8173047_01
Expiratory high-resolution computed tomography (HRCT) revealed bilateral mosaic attenuation (arrows) consistent with air trapping.
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F1
Inspiratory and expiratory chest high-resolution computed tomography (HRCT) revealed bilateral mosaic attenuation, consistent with air trapping (Figure 1).
Thoracoscopic lung biopsy from a coffee roasting/packaging facility worker exposed to diacetyl showing (a) perivascular inflammatory infiltrates [black arrow] and (b) respiratory epithelium [gray arrows] and multinucleate giant cells with cholesterol clefts [black arrow].
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F2
Thoracoscopic lung biopsy revealed focal mild cellular bronchiolitis and pleuritis, including perivascular inflammatory infiltrates (Figure 2a; black arrow), and peribronchiolar giant cells/granulomas (Figure 2b; black arrow), but no evidence of fibrosis or destruction of the bronchioles.
Percent predicted forced expiratory volume in 1 second (%pred FEV1). percent predicted forced vital capacity (%pred FVC), and ratio of FEV1 to FVC expressed as a percent (%FEV1/FVC) for patient diagnosed with flavoring-related lung disease, August 2016 to July 2019.
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F3
Periodic spirometry through 2019 (Table 1 and Figure 3), demonstrated persistent mixed pattern without improvement despite cessation of exposure.