PMC8558046_01
Intranasal neurostimulator and various application methods. (A) Intranasal neurostimulator device; (B) intranasal application; (C) extranasal application (Photos courtesy of Allergan ).
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During the visit, they received two test applications (intranasal and extranasal) in random sequence (Figure 1), separated by at least 60 min. For the intranasal application, briefly, the device was turned on and the tips of the device were inserted into the nasal cavity for approximately 3 min (Figure 1B). For the extranasal application, the device was turned on and the tips were placed on the outside surface of the nose, just below the nasal bridge, for approximately 3 min (Figure 1C).