PMC9069638_01
Oral clinical examination.
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A = initial visit (at age 5). A well-circumscribed brownish round-to-oval macule on the hard palatal mucosa, adjacent to the left first primary upper molar of approximately 0.2 cm in maximum diameter.
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B = second visit (at age 8). An elongated ovoid brownish macule with slight asymmetry and colour variation; a small increase in size compared to the first appearance is seen.
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fig1
Oral clinical examination revealed a well-circumscribed brownish round to ovoid macule on the hard palatal mucosa, adjacent to the left first primary upper molar, measuring approximately 0.2 cm in maximum diameter (Figure 1A). Indeed, on clinical examination, the lesion appeared somewhat increased with a more ovoid and elongated shape (measuring approximately 0.3 x 0.2 cm); in addition, slight asymmetry and colour variation were noticed (Figure 1B).
Histopathologic examination of melanocytic nevus (hematoxylin and eosin stain, original magnification x200).
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A and B = nevus cells randomly distributed along the basal layer of the epithelium, forming small nests in the junctional area and within the papillary layer of the lamina propria.
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fig2
The lesion was excised, and microscopic examination revealed nevus cells randomly distributed along the basal cell layer, organized into nests along the junctional area and within the papillary layer of lamina propria (Figure 2A and 2B); mitoses were absent.
Immunohistochemical examination of melanocytic nevus (original magnification x100).
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Positivity of nevus cells for: A = SOX-10; B = Melan-A.
jomr-13-e5-g003.jpg
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fig3
Immunohistochemical evaluation showed positivity of nevus cells for SOX-10 (Figure 3A) and Melan-A (Figure 3B).