PMC4308043_01
(A) Section of cervix showing a proliferation of small round cells infiltrating the stoma and in glands (H+E, x40), (B) Neoplastic cells characterized by scant cytoplasm surrounding hyperchromatic round to oral nuclei. There were no glandular structures or intracytoplasmic mucin. (H+E, x400), (C) Small cell population with some cells having hyperchromatic or pyknotic nuclei while others have paler chromatin with prominent nucleoli (H+E, x600), (D) A subpopulation of cells shows strong cytoplasmic staining with antibodies directed against synaptophysin (Immunoperoxidase, x400).
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F1
Histologic sections of the cervical tumor showed invasion of the stroma with a population of small round cells (Figure 1A). The individual cells had scant cytoplasm (Figure 1B). Other nuclei had a paler chromatin appearance with distinct nucleoli (Figure 1C). The neoplastic cell population demonstrates strong cytoplasmic staining for synaptophysin in some cells (Figure 1D).