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Timeline with relevant anamnestic data.
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F1
At the age of 35 years, the patient visited our outpatient clinic with a progressing gait disturbance and muscular pain which led to admission (for the timeline of symptoms, see Figure 1).
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[123I] FP-CIT-SPECT of our EOPD patient showed profoundly reduced binding at dopamine transporters on nigrostriatal neurons. Reductions were slightly more pronounced on the left side for the caudate nucleus (right: -41%; left: -48%) and the putamen (right: -67%; left: -71%) as compared to the age-related reference (DaTQUANTTM software, GE Healthcare).
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F2
[123I]N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane (FP-CIT) SPECT (Single-photon emission computed tomography) revealed profoundly and left-pronounced reduced striatal uptake at presynaptic dopamine transporters, suggesting a neurodegenerative Parkinson syndrome (Figure 2). [18F]FDG-PET's search of the brain for signs of an atypical Parkinson's syndrome remained unremarkable.
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