PMC6815603_01
Macroscopic and microscopic descriptions of WD in case number 1. (a) Intestinal lipodystrophy in duodenum. (b) CD68 positive for macrophage-duodenal biopsy. (c) PAS-positive granules-duodenal biopsy.
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fig1
The histological findings resulted in PAS-positive granules in macrophages (intestinal lipodystrophy) (Figure 1).
Course of body temperature ( C) in case number 1.
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fig2
There were no relapses after 6 months and was a significant weight recovery (Figures 2 and 3).
Course of CRP (mg/l) in case number 1.
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fig3
There were no relapses after 6 months and was a significant weight recovery (Figures 2 and 3).
PMC6815603_02
Course of CRP (mg/l) in case number 2.
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fig4
Tropheryma whipplei detection by PCR on saliva and stool in case number 2 (original report from the Reference Laboratory of Marseille, France).
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fig5
Thus, the duodenal samples, as well as other samples from stool and saliva, collected before the introduction of the antibiotic therapy, were analyzed for T. whipplei by PCR in the Reference Center of Marseille, resulting all positive (Figures 5 and 6).
Tropheryma whipplei detection by PCR on duodenum sample in case number 2 (duplicate from the original report from the Reference Laboratory of Marseille, France).
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fig6
Thus, the duodenal samples, as well as other samples from stool and saliva, collected before the introduction of the antibiotic therapy, were analyzed for T. whipplei by PCR in the Reference Center of Marseille, resulting all positive (Figures 5 and 6).