PMC2716486_01
Esophagoscopy showing several flat and black pigmented mucosal lesions in the distal esophagus and esophagogastric junction (arrows).
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fig1
Esophagoscopy revealed several flat and black pigmented mucosal lesions with a short shallow mucosal break in the distal esophagus and esophagogastric junction (Figures 1  and 2).
Esophagoscopy showing flat and black pigmented mucosal lesions with reflux esophagitis in close up of esophagogastric junction.
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PMC2716486_01_GRP2009-285753.002.jpg
fig2
Esophagoscopy revealed several flat and black pigmented mucosal lesions with a short shallow mucosal break in the distal esophagus and esophagogastric junction (Figures 1  and 2).
Histologically the tumor mainly consisted of poorly cohesive neoplastic cells with hyperchromic muclei and cytosolic melanin granules which predominantly proliferated in the mucosa (Hematoxylin and eosin stain, x400).
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PMC2716486_01_GRP2009-285753.003.jpg
fig3
Microscopic examination of biopsy specimens showed proliferation of poorly cohesive neoplastic cells with hyperchromic nuclei and cytosolic melanin granules which predominantly proliferated in the mucosa (Figure 3, H&E stain, x400).
Immunohistochemical stain. The cells sporadically showed immunoreactivity for S-100 protein (x400, a) and HMB-45 antibody (x400, b).
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PMC2716486_01_GRP2009-285753.004.jpg
fig4
The cells sporadically showed immunoreactivity for S-100 protein and HMB-45 antibody (Figure 4, x400).