PMC3321533_01
Chest radiograph at initial presentation showing large right hilar mass with right paratracheal soft tissue mass (see arrows).
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Initial chest radiograph (Figure 1) showed a large right hilar mass with right paratracheal soft tissue mass.
Pretreatment computed tomography of the thorax demonstrating a large anterior mediastinal mass (see arrows).
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Chest CT (Figure 2) demonstrated a large anterior mediastinal mass (13 cm x 6 cm) compressing the SVC, right pleural effusion, and subcarinal and pericardiac lymphadenopathy.
Positron emission tomography (PET) scan showing a hypermetabolic mediastinal mass (see arrows).
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Positron emission tomography (PET) scan confirmed a hypermetabolic mediastinal mass extending to the subcarinal region and inferiorly to diaphragmatic surface along the right side of the heart with maximum standardized uptake value of 6.5 (Figure 3).
The tumor cells (see arrows) exhibit features of small-cell carcinoma: nuclear molding, high nuclear-to-cytoplasm ratio, and fine chromatin pattern/"salt and pepper" nuclei. H and E (hematoxylin and eosin) staining.
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fig4
The tumor cells exhibited features of small-cell carcinoma: nuclear molding, high nuclear-to-cytoplasm ratio, and fine chromatin pattern/"salt and pepper" nuclei (Figure 4).
Positive synaptophysin stain, consistent with neuroendocrine origin (see arrows).
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