PMC6970194_01
Serial serum 25-hydroxyvitamin (OH)-D concentrations in a dog with cholecalciferol rodenticide toxicosis starting at the time of initial presentation (a; Day 1) as well as on subsequent evaluations on (b; Day 26, c; Day 78, d; Day 120, e; Day 179, f; Day 286, g; Day 326). The dog received prednisone (0.6 mg/kg PO q24 h), aluminum hydroxide (16 mg/kg PO q12 h), and Hills Prescription Diet k/d (Hill's Pet Nutrition Inc., Topeka, KS) from the time of hospital discharge (day 8) to (f; Day 286). Serum 25(OH)D measured at Michigan State University (MSU) Diagnostic Center for Population and Animal Health with a commercially available and validated radioimmunoassay. The reference interval for canine serum 25(OH)D established by MSU is 109-423 nmol/L. The dotted black line denotes the upper limit of the reference interval.
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F1
Serum 25-hydroxy (OH)D concentration on day 1 (~3 days after cholecalciferol rodenticide ingestion) was markedly increased (3,625 nmol/L; reference interval 109-423 nmol/L; Figure 1). The serum 25(OH)D concentration was still markedly increased (6,091 nmol/L; Figure 1). While all parameters on serum biochemical profiles and ionized calcium concentrations remained within their respective reference intervals (Table 2), the serum 25(OH)D concentration, remained mildly above the reference interval, day 326 (Figure 1).