PMC4038867_01
(a) Magnetic resonance imaging (MRI) Coronal view with contrast; (b) MRI Sagittal view; (c) histopathology showed proliferation of cells with hyperchromatic nuclei and scant cytoplasm
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F1
Severe vasogenic edema was noticed at the cerebellum, with a mass effect and a resultant tonsillar herniation [Figure 1a and b]. Histopathologic examination showed highly cellular neoplasm composed of cells with medium sized and hyperchromatic nuclei, little cytoplasm and moderate nuclear pleomorphism as well as foci of necrosis, which is indicative of classic medulloblastoma [Figure 1c].
PMC4038867_02
(a) Axial magnetic resonance imaging with contrast; (b) histopathology showed proliferation of undifferentiated cells with nuclear molding, surrounding vessel
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F2
Though MRI-based initial diagnosis was meningioma [Figure 2a], Histopathologic examination showed highly cellular neoplasm composed of large cells with hyperchromatic nuclei, scant cytoplasm, nuclear molding and moderate pleomorphism,consistent with undifferentiated medulloblastoma [Figure 2b].
PMC4038867_03
(a) Magnetic resonance imaging axial view T2; (b) coronal view T2; (c) histopathology showed hypocellular areas with nodular fashion (Pale islands)
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F3
MRI investigations picked a solid mass in the posterior fossa and the left hemispheric lesion and mild hydrocephalus [Figure 3a and b]. Histopathologic examination showed proliferation of large cells with hyperchromatic nuclei and scant cytoplasm, as well as nodular foci of tumor in less cellular areas, which is indicative of desmoplastic nodular medulloblastoma [Figure 3c].
PMC4038867_04
(a) Axial magnetic resonance imaging with contrast; (b) histopathology showed proliferation of hyperchromatic cells with areas of necrosis
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F4
Brain MRI detected a huge cerebellar hemispheric mass with cystic and solid components and extension to the brain stem and cerebellopontine angle [Figure 4a]. Histopathologic examination showed proliferation of large neoplastic cells with hyperchromatic nuclei and scant cytoplasm, moderate mitosis, extensive areas of necrosis and nodular arrangement, which is indicative of desmoplastic nodular medulloblastoma [Figure 4b].