PMC9125307_01
A 54-years-old patient with a pedunculated nodule at the tip of glans that was show to be leiomyosarcoma on histopathological exam.
fonc-12-851003-g001.jpg
PMC9125307_01_fonc-12-851003-g001.jpg
f1
A physical examination identified a nodule at the tip of the penis, measuring 2.0 x 1.0 cm ( Figure 1 ).
Features of Penile intraepithelial neoplasia in the glans of a patient with leiomyosarcoma. Dysplastic epithelial cell in all squamous layers (A). Immunohistochemistry staing for: Ki67 in suprabasal layers (B), p16 (C) and p53 (D).
fonc-12-851003-g002.jpg
PMC9125307_01_fonc-12-851003-g002.jpg
f2
A focal area compatible with Penile intraepithelial neoplasia (PeIN) was also observed, with epithelial layers showing immunostaining for P16, P53, and Ki67 ( Figure 2 ).
Histopathological and immunohistochemical aspects of leiomyosarcoma of the penis: spindle cell malignant neoplasm with a high number of mitoses (white arrow) and atypical mitoses (black arrow) (A); the neoplasm was negative for epithelial markers: epithelial membrane antigen (B) and pan-cytokeratin (C); the immunohistochemical expression was strong and diffuse for smooth muscle markers: alpha-smooth muscle actin (D) and calponin (E); the neoplasm is also negative expression for: p16 (F), S100 (G) and CD34 (H).
fonc-12-851003-g003.jpg
PMC9125307_01_fonc-12-851003-g003.jpg
f3
Tumor cells were negative for, CD34, CD31, v-ets erythroblastosis virus E26 oncogene like isoform 2 (ERG), and FLI1 ( Figure 3 ).