PMC4036137_01
a-c CT findings. Contrast CT showed the tumor to have a ring enhancement area in the caudate lobe of the liver and a high- to low-density round area was shown in the internal part of the tumor. Arrows indicate the tumor. d-f MRI findings. The T1-weighted image showed a high-intensity round area in a low-intensity round area, the T2-weighted image showed a high-intensity round area in a low-intensity round area, and gadoxetic acid-enhanced MRI (EOB) showed a slightly contrasted low-intensity area in the caudate lobe of the liver. Arrows indicate the tumor.
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F1
Contrast CT showed the tumor to have a ring enhancement area and a high- to low-density round area (fig. 1a-c). The T1-weighted image showed a high-intensity round area in a low-intensity area, the T2-weighted image showed a high-intensity round area in a low-intensity area, and gadoxetic acid-enhanced MRI showed a slightly contrasted low-intensity area in the same segment (fig. 1d-f).
Biopsy finding. Cellular and structural atypia, enlarged hyperchromatic nuclei and two or three layers of trabecular pattern, which indicated moderately differentiated HCC, were found in the specimen.
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F2
Cellular and structural atypia, enlarged hyperchromatic nuclei and two or three layers of trabecular pattern, which indicated moderately differentiated HCC, were found in the specimen (fig. 2).
Macroscopic and pathological finding of the resected specimen. a The tumor consisted of viable and necrosis areas with well-demarcated nodular lesions at the caudate lobe (S1). The viable tumor size was 11 mm in diameter. b Histological examination showed a trabecular and pseudo-glandular structure with enlarged nuclei and hyperchromatins, which indicated moderately differentiated HCC in the viable area. c, d The necrosis area consisted of sclerotic fibrous stroma and liquefaction (arrows), and hyalinized degeneration (arrow) with hemosiderin-laden macrophages, plasmacytes and fibroblasts was found. e, f Vessel occlusion with organization (e), stenotic arteries with wall thickness (f) and mild chronic inflammation in fibrously enlarged portal areas were found in the necrotic area.
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F3
The viable tumor size was 11 mm in diameter (fig. 3a). Histological examination showed a trabecular and pseudo-glandular structure with enlarged nuclei and hyperchromatins, which indicated moderately differentiated HCC in the viable area (fig. 3b). The necrosis area consisted of sclerotic fibrous stroma and liquefaction, and hyalinized degeneration with hemosiderin-laden macrophages, plasmacytes and fibroblasts was found (fig. 3c, d). Vessel occlusion with organization (fig. 3e), stenotic arteries with wall thickness (fig. 3f) and mild chronic inflammation in fibrously enlarged portal areas were found in the necrotic area.