PMC8713720_01
Numerous palpable and non-palpable purpura on the lower legs.
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At presentation, there were numerous palpable and non-palpable purpura, approximately 3 mm in diameter, on the extremities (Figure 1).
Histopathological features of the purpura. Perivascular neutrophil infiltration and nuclear dust deposition in the upper dermis. (H&E staining, x100).
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Biopsy specimen from purpura on the right thigh revealed perivascular infiltration of neutrophils with nuclear dust and extravasated erythrocytes in the upper dermis (Figure 2), which was consistent with leukocytoclastic vasculitis.
Direct immunofluorescence showed deposition of IgA (A) and C3 (B) in the vessel walls of the upper dermis (x200).
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Direct immunofluorescence showed deposition of IgA and C3 in the vessel walls of the upper dermis (Figure 3A and B).