PMC4899544_01
The tumor infiltrated by individual cells in a pattern mimicking lobular breast carcinoma, with scattered signet ring cells (inset) with a globule of mucin pushing the nucleus to the side, creating the signet-ring appearance.
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The LEEP cone biopsy and vaginal biopsy showed adenocarcinoma characterized by small infiltrating cells with small signet ring-like intracytoplasmic lumina staining for periodic acid Schiff(PAS), growing in cords and sheets without desmoplasia, mimicking lobular carcinoma of the breast (Fig. 1).