PMC7170742_01
MRI Brain: A) axial; T2W1 B) T1W1 show heterogeneous peripheral left parieto-occipital solid mass with a cystic component; heterogeneous enhancement with rim enhancement seen in B) in keeping with high grade malignancy
PAMJ-35-26-g001.jpg
PMC7170742_01_PAMJ-35-26-g001.jpg
f0001
On plain CT scan of the head (Figure 1), there was a complex lesion with cystic and solid components and calcification along left parieto-occipital lobe associated with florid vasogenic edema.
Gliosarcoma: hematoxylin and eosin staining (H&E); A) glial component X20; B) glial component X40; C) sarcomatous component X20; D) sarcomatous component X40
PAMJ-35-26-g002.jpg
PMC7170742_01_PAMJ-35-26-g002.jpg
f0002
This was alternated by a sarcomatous part revealing fascicles of spindle cells with atypical, highly pleomorphic nuclei (some bizarre nuclei) (Figure 2).
Immunohistochemical and special stains; A) reticulin in sarcomatous component; B) vimentin in sarcomatous component; C) GFAP in glial and sarcomatous component; D) GFAP in glial component
PAMJ-35-26-g003.jpg
PMC7170742_01_PAMJ-35-26-g003.jpg
f0003
Immunohistochemical analysis revealed the glial component to be Glial Fibrillary Acidic Protein (GFAP) positive and the sarcomatous component as diffusely positive for reticulin and vimentin but negative for GFAP Figure 3.