PMC5376440_01
(a) Dense plasma cell infiltrate, H&E, 40x; (b) CD138 immunostain labeling plasma cells, IHC 40x; (c) Kappa in situ hybridization with only rare plasma cell labeling, ISH, 40x; (d) Lambda in situ hybridization with most plasma cells labeling, ISH, 40x.
CRIONM2017-4296802.001.jpg
PMC5376440_01_CRIONM2017-4296802.001.jpg
fig1
Hematoxylin-eosin staining of the lip biopsy revealed a dense plasmacytic infiltration in the deep dermis (see Figure 1(a)). Immunohistochemistry was positive for CD138 (see Figure 1(b)) and revealed that most plasma cells were lambda positive and with rare kappa-positive plasma cells (see Figures 1(c) and 1(d)).