PMC6167997_01
Body temperature change after CAR T-cell therapy.. Abbreviation: CAR, chimeric antigen receptor.
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She developed febrile syndrome from day +1 to +5 and her body temperature reached a peak of 40.7 C at 16:00 on day +2 (April 23) (Figure 1), indicating a low-grade cytokine release syndrome (CRS) (Figure 2 and Table 2). Physiological parameters of the patient before and after the therapy were listed as following: body temperature (Figure 1), CRP (Figure 2), CAR T-cell expansion (Figure 3), ultrasound results (Figure 4), and cytokine levels (Table 2).
CRP change after CAR T-cell therapy.. Abbreviations: CRP, C-reactive protein; CAR, chimeric antigen receptor.
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She developed febrile syndrome from day +1 to +5 and her body temperature reached a peak of 40.7 C at 16:00 on day +2 (April 23) (Figure 1), indicating a low-grade cytokine release syndrome (CRS) (Figure 2 and Table 2). Physiological parameters of the patient before and after the therapy were listed as following: body temperature (Figure 1), CRP (Figure 2), CAR T-cell expansion (Figure 3), ultrasound results (Figure 4), and cytokine levels (Table 2). Figure 4C exhibited the post-therapy 2-month follow-up check and ultrasound indicated normalsized uterus with even echo signal in myometrium and smooth anterior and posterior uterine. Figure 4D and E shows ultrasound images of normal sized uterus on day +90 and day +120 post-treatment, respectively.
Expansion of CAR T-cell from peripheral blood after therapy.. Abbreviation: CAR, chimeric antigen receptor.
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Physiological parameters of the patient before and after the therapy were listed as following: body temperature (Figure 1), CRP (Figure 2), CAR T-cell expansion (Figure 3), ultrasound results (Figure 4), and cytokine levels (Table 2).
Pelvic ultrasound results of the patient before and after CAR T-cell therapy.. Notes: (A) Ultrasound results from day -7 before CAR T-cell therapy; (B-F) day +28, day +60, day +90, day +120, and day +360 ultrasound results after CAR T-cell therapy.. Abbreviation: CAR, chimeric antigen receptor.
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Physiological parameters of the patient before and after the therapy were listed as following: body temperature (Figure 1), CRP (Figure 2), CAR T-cell expansion (Figure 3), ultrasound results (Figure 4), and cytokine levels (Table 2). As shown in Figure 4A, on day -7 before CAR T-cell therapy, the ultrasound indicated a smooth surface of anterior and posterior uterine wall. Figure 4B. Figure 4C exhibited the post-therapy 2-month follow-up check and ultrasound indicated normalsized uterus with even echo signal in myometrium and smooth anterior and posterior uterine. Figure 4D and E shows ultrasound images of normal sized uterus on day +90 and day +120 post-treatment, respectively. The most recent 12-month (day +360) follow-up check (April 26, 2018) did not show significant restrictive echo with abnormality, nor obvious blood flow signal (Figure 4F).