PMC5656353_01
SPECT images using Tc-99m TRODAT-1.. Notes: (A) SPECT images under bupropion use. (B) SPECT images after discontinuation of bupropion for 14 days. The striatum is marked by the dotted line.. Abbreviations: L, left; R, right; SPECT, single-photon emission computed tomography.
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f1-ndt-13-2637
TRODAT-1 showed decreased DAT binding capacity in bilateral striata (uptake ratio of striata: right 0.31; left 0.27, Figure 1A) and immeasurable visual score of striata due to an atypical pattern of striatal uptake. The uptake ratio was calculated by the following equation: (The average count density of striatum - the average count density of the reference regions)/the average count density of the reference regions. The reference regions were the cerebellar and the occipital cortex. The striatum is marked by the dotted line in Figure 1. The follow-up SPECT after 14 days showed improvement in the uptake ratio of striata (right 0.47; left 0.56, Figure 1B) and the visual score of striata (Score 0 with intact striatal shape).