PMC4857354_01
Imaging and histological characteristics of involved parotid gland, lung, liver and skin: (a) Contrast-enhanced MRI of head showed homogeneously enlarged parotid glands (arrow); (b) HRCT (lung window) revealed randomly distributed lesions in both lung fields, mainly included cysts (fine arrows) of variable size, shape and wall and nodules (coarse arrow); (c) contrast-enhanced CT scan indicated intrahepatic diffuse small nodules (arrows) and (d) CD1a antibody staining positive (arrow) in skin (magnification 400x).. MRI: magnetic resonance imaging; CT: computerized tomography; HRCT: high-resolution computed tomography.
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Head MRI indicated homogeneous enlargement of bilateral parotids (Figure 1(a)) and confluent lymph nodes. Imaging features on pulmonary high-resolution CT (Figure 1(b)) included combination of nodular or reticulonodular opacities with ill-defined margins and cysts with different thick walls, variable sizes and bizarre shapes. Abdominal CT showed multiple round and oval hypodense nodules within liver (Figure 1(c)). Punch biopsy of skin revealed LCs admixed with eosinophils and lymphocytes infiltration, and confirmatory staining with CD1a (Figure 1(d)) and Langerin was positive.