PMC4607473_01
HISTOPATHOLOGY AND IMMUNOPHENOTYPE OF BURKITT LYMPHOMA LYMPHOMA. H&E staining shows Burkitt lymphoma with uniform intermediate-sized tumor cells with small nucleoli, fine chromatin, and frequent apoptotic bodies. Immunohistochemistry shows strong homogenous staining for CD20, Ki67 (MIB1), CD10, BCL6, and MYC. Tumor cells are negative for BCL2. FISH studies for MYC using dual color break apart probes show one allele with colocalization of both probes (red and green) and one allele with segregation of both probes.
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F1
Core needle biopsy from a retroperitoneal node showed BL with positive FISH studies for MYC gene rearrangement. (Figure 1) EBER1-mRNA by in-situ hybridization (ISH) was positive.
PRE & POST TREATMENT PET-CT SCAN SHOWING COMPLETE RESPONSE TO CHEMOTHERAPY. Pre-treatment positron emission tomography (PET) - computed tomography (CT) scan (A) shows intense fluoro-deoxy glucose (FDG) uptake corresponding to a 6 cm right axillary lymph node, along with abnormal glucose uptake in the left axillary, left para-aortic, mediastinal and right external iliac lymph nodes. A follow-up PET-CT scan (B) 3 months after starting chemotherapy shows a complete response.
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F2
He achieved a complete response (Figure 2) and has remained in remission for the past 51 months.
PMC4607473_02
HISTOPATHOLOGY AND IMMUNOPHENOTYPE OF BURKITT LYMPHOMA LYMPHOMA. H&E staining shows Burkitt lymphoma with uniform intermediate-sized tumor cells with small nucleoli, fine chromatin, and frequent apoptotic bodies. Immunohistochemistry shows strong homogenous staining for CD20, Ki67 (MIB1), CD10, BCL6, and MYC. Tumor cells are negative for BCL2. FISH studies for MYC using dual color break apart probes show one allele with colocalization of both probes (red and green) and one allele with segregation of both probes.
nihms698179f1.jpg
PMC4607473_03_nihms698179f1.jpg
F1
Core needle biopsy from a retroperitoneal node showed BL with positive FISH studies for MYC gene rearrangement. (Figure 1) EBER1-mRNA by in-situ hybridization (ISH) was positive.
PMC4607473_03
HISTOPATHOLOGY AND IMMUNOPHENOTYPE OF BURKITT LYMPHOMA LYMPHOMA. H&E staining shows Burkitt lymphoma with uniform intermediate-sized tumor cells with small nucleoli, fine chromatin, and frequent apoptotic bodies. Immunohistochemistry shows strong homogenous staining for CD20, Ki67 (MIB1), CD10, BCL6, and MYC. Tumor cells are negative for BCL2. FISH studies for MYC using dual color break apart probes show one allele with colocalization of both probes (red and green) and one allele with segregation of both probes.
nihms698179f1.jpg
PMC4607473_03_nihms698179f1.jpg
F1
Core needle biopsy from a retroperitoneal node showed BL with positive FISH studies for MYC gene rearrangement. (Figure 1) EBER1-mRNA by in-situ hybridization (ISH) was positive.
RAPIDLY PROGRESSIVE LYMPHADENOPATHY. CT scan shows bulky right inguinal (A) and retroperitoneal (B) lymphadenopathy with an 11x8 cm mass encasing the iliac and common femoral veins (arrow).
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F3
CT scan showed bulky lymphadenopathy above and below the diaphragm with an 11 cm right groin mass encasing the iliac and common femoral veins. (Figure 3) A Doppler study showed extensive thrombosis of the right leg involving the distal external iliac and femoral veins.