PMC9978767_01
Gadolinium-enhanced T1-weighted MRI before (A) axial, (B) coronal and after (C) axial, (D) coronal) gross total resection of glioblastoma at our institute.
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Gross total resection of the tumor, placement of carmustine wafer in the resection cavity and cranioplasty were conducted at our institute ( Figure 1 ).
Sagittal CT (A), T2-weighted (B), and gadolinium-enhanced T1-weighted (C) MRI sequences of the spine showing development of metastatic lesion.
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CT showed an osteolytic mass on the body of the first lumbar vertebrae and MRI showed an enhanced lesion constricting the spinal canal ( Figure 2 ).
Immunohistopathological investigation showed densely infiltrating spindle-shaped cells with eosinophilic cytoplasm accompanied with regions of necrosis, consistent with glioblastoma (A) primary site, (B) lumbar metastasis). The cells were positive for glial fibrillary acidic protein (GFAP) (C) and negative for mutant isocitrate dehydrogenase 1 (IDH1-R132H) (D). MIB-1 labeling index was 30% (E). The original magnification was x200 (A-E).
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Needle biopsy of the mass on the first lumbar vertebrae showed densely infiltrating spindle-shaped cells with eosinophilic cytoplasm accompanied with regions of necrosis, which was consistent with glioblastoma ( Figure 3 ).
Copy number profiles of primary and metastatic lesions calculated by methylation array are shown. Copy number baseline imbalance was enhanced for the metastatic lesion compared with the primary lesion.
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