PMC7330014_01
Left picture shows the frontal view of the patient showing microcephaly, prominent nose (wide bridge, broad root, columella under ala nasi), Middle picture shows Oligodontia, Right picture shows the Generalized brachydactyly (A written consent was obtained from the patient's parents to publish this image).
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F1
In addition, clinical and paraclinical examinations revealed several abnormalities including microcephaly, beaked prominent nose with broad nasal bridge, dental abnormality(Oligodontia), short stature, generalized brachydactyly, gradual deterioration of brain functioning, menstrual irregularity, clitoromegaly, acanthosis nigricans, diabetes mellitus (DM), hyperinsulinemia, hypertriglyceridemia, and insulin resistance (Figure 1).