PMC3959304_01
Colonic mucosa with dilated crypts and presence of signet-ring cells (H.E. x100) A, Signet-ring cells in dilated crypts (H.E.x200) B
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F1
In some areas the crypts were replaced by signet-ring cells, confined above the basement membrane of the crypts and did not infiltrate the lamina propria (Fig. 1).
Signet-ring cells cytokeratin 20 positive (x40) A, Signet-ringcells MIB-1 negative (x40)
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PMC3959304_01_AnnGastroenterol-24-222-g002.jpg
F2