PMC3547696_01
(1a) Computed tomography of the thyroid tumor. (1b) Microscopic examination of the thyroid revealed that the tumor is comprised of scattered large atypical cells embedded in a background of histiocytes and small lymphocytes (hematoxylin and eosin staining). (1c,1d) The scattered atypical cells were positive for CD20 (1c) and CD79a (1d). (1e) Small lymphocytes represent CD3-positive T-cells. (1f) Substantial numbers of CD68-positive histiocytes are also intermingled. (1g) Gallium scintigraphy showed increased gallium uptake in the thyroid exclusively.
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Computed tomography (CT) scan showed a diffuse and massive thyroid tumor narrowing the tracheal lumen (Figure 1a). Thorough pathological examination of the thyroid tumor revealed scattered neoplastic large B-lymphocytes, which were CD20+, CD79a+, CD5-, CD10-, CD15-, and CD30-, and surrounding abundant T-lymphocytes (CD3+) and histiocytes (CD68+) (Figure 1b - 1f). Gallium scintigraphy showed increased gallium uptake in the thyroid with no other abnormal signals (Figure 1g).