PMC6883668_01
Cross-sectional imaging of the tumor on T1-weighted images with contrast.
Coronal cuts (A and B) show the tumor extending along the nasopharynx,
infratemporal fossa, and abutting the skull base. The tumor did not invade
the skull base. Axial cut (C) demonstrates the lateral extension of the
tumor into the distal portion of the eustachian tube along the
pterygoids.
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A magnetic resonance imaging (MRI) showed a well-circumscribed 4.5 x 2.4 x 4 cm mass centered in the right fossa of Rosenmuller with anterior extension to the basal lamalle as well as the contralateral side (Figure 1).
Tumor histology. A, H&E x40 low-power view demonstrating an infiltrative
carcinoma growing in solid nests and cords with areas of glandular formation
in a background of hyalinized stroma. B, H&E x100 multiple areas of
glandular formation (ductal differentiation) present in a background of
hyalinized stroma. Areas of cytoplasmic clearing more typical of HCC can be
appreciated in the more solid growth pattern. C, H&E x100 focal areas of
the tumor demonstrated more classic morphology, with clear cells juxtaposed
to peritumoral hyaline stroma. D, H&E x200 minor component consisting of
clear cells juxtaposed to peritumoral hyaline stroma. E, H&E x200
evidence of mucinous differentiation with mucin production.
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Final pathology of the biopsy was consistent with a high-grade HCCC with ductal and mucinous differentiation and necrosis (Figure 2).