PMC5491737_01
(A,B) multiple osteolytic lesions in the skull, humerus, pelvic bone, both femurs, and both tibias; Skull X-ray (front and profile): reveals multiple lytic lesions; (C) front chest X-ray revealed proximal metaphyseal humoral lytic lesion responsible for fracture; (D) X-ray reveals multiple osteolytic lesions in pelvic bone and both femurs; (E) lumbosacral and pelvis CT Scan revealed diffuse lytic lesions and permeative bony lesions in iliac bones; (F) X-ray of knee joints reveals metaphyseal lytic lesions in both distal femurs and proximal tibiae
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Skeletal radiographs and computed tomography (CT) scan of the skull, thorax and abdomen revealed osteolytic lesions in the skull, pelvis and long bones Figure 1.
Acute lymphoblastic leukemia-histology; (A) HE stain x 50; diffuse infiltration of the bone marrow by small round cells; (B) HE stain x 100; nuclei are convoluted with fine chromatin and frequent mitosis; (C) CD10 stain x 100; diffuse expression in neoplastic cells
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TdT negative) Figure 2. Cerebrospinal fluid (CSF) cytology was negative for malignant cells. Cytogenetics by conventional karyotyping showed a deletion of 12p (del(12) (p13) [7]/46,XY [13]).