PMC6192138_01
Initial MRI showed diffuse, patchy foci of increased FLAIR signal in the periventricular, deep, and subcortical white matter.
CRINM2018-1873582.001.jpg
PMC6192138_01_CRINM2018-1873582.001.jpg
fig1
His initial brain MRI showed diffuse, patchy foci of increased FLAIR signal in the periventricular, deep, and subcortical white matter (Figure 1).
Post-cyclophosphamide MRI showed progressive periventricular, mid, and also a component of superficial/juxtacortical white matter T2/FLAIR hyperintensity, the latter of which is more apparent within the frontal lobes. There has been further progression of hydrocephalus with diffuse ventricular enlargement.
CRINM2018-1873582.002.jpg
PMC6192138_01_CRINM2018-1873582.002.jpg
fig2
T2/FLAIR hyperintensity, the latter of which is more apparent within the frontal lobes. There has been further progression of hydrocephalus with diffuse ventricular enlargement (Figure 2).
Post-rituximab MRI did not show any significant interval change in findings suggesting leptomeningitis/pachymeningitis, and foci of prolonged T2 values within the white matter.
CRINM2018-1873582.003.jpg
PMC6192138_01_CRINM2018-1873582.003.jpg
fig3