PMC5056304_01
IgD levels over the course of 6 years of treatment.
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December 2015 were 4000 mg/L and came down drastically to 5 mg/L in May 2016 after 5 cycles of daratumumab showing very good partial response (Figure 1). During his first infusion, he developed a grade 3 infusion reaction.
Transfusion requirements prior to starting daratumumab and after daratumumab.
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His transfusion requirements which had been very high throughout his disease course requiring multiple transfusions with packed red blood cells (PRBCs) also came down dramatically with stable hemoglobin levels after the start of daratumumab (Figure 2).