PMC10073570_01
Necropsy findings in rabbit #4 (Oryctolagus cuniculus cuniculus) case. Liver with an enlarged, pale, and distinct lobular pattern with light gray discoloration in the edges of the lobes (likely a postmortem change) (A). Lungs (B) and uterus (C) had multifocal to coalescing hemorrhages.
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F1
At necropsy, the liver had an enlarged, pale, and distinct lobular pattern with regional areas of light gray discoloration in the edges of all lobes (likely a postmortem change) (Figure 1A). Additionally, the lungs (Figure 1B) and uterus (Figure 1C) had multifocal to coalescing hemorrhages.
Liver with a severe generalized hepatocellular necrosis with hemorrhage, most evident in the periportal areas, H&E stain (A). Liver, detail of necrotic cells, H&E [(A) inset]. Liver. Marked hepatocytes' immunolabeling with monoclonal antibody (Mab) against rabbit hemorrhagic disease virus capsid proteins (B).
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F2
Hepatocellular necrosis with hemorrhage was detected in all sections examined (Figure 2A), generally with a random distribution, although more evident in the periportal areas. Figure 2B depicts the hepatocytes' positive staining with the immunohistochemical technique, confirming the presence of RHDV.