PMC8558305_01
CT image of primary sinonasal SDC tumor (indicated by black arrows).
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F1
Additional imaging examinations revealed a large sinonasal process (Figure 1).
Photomicrographs of case report 1: cervical lymph node containing an SDC metastasis. (A) H&E stain 1X, (B) H&E stain 10X, (C) H&E stain 21X, (D) AR stain 20X, AR441 (BioCare Medical), (E) HER2neu stain 21X, HercepTest (Dako Agilent).
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F2
The tumor cells were positive for androgen receptor (AR) (see Figure 2).
Time-line of case report 1.
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F3
Apart from Cr(VI) exposure, the patient may have come into contact with other chemical substances during a previous occupation (Figure 3).
PMC8558305_02
CT image of primary submandibular SDC tumor (indicated by white arrows).
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F4
PET/CT imaging showed a primary tumor originating from the right submandibular gland (Figure 4) and also right lymphadenopathy at level I-V, suspect for lymph node metastases, and a lesion in the 3rd thoracic vertebra.
Photomicrographs of case report 2: biopsy of SDC bone metastasis in thoracic vertebra 3. 1. (A) H&E stain 1X, (B) H&E stain 10X, (C) H&E stain 20X, (D) AR stain 5X (photomicrograph from referring center), (E) HER2neu stain 10X, HercepTest (Dako Agilent).
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F5
Biopsy of the bone lesion revealed a SDC metastasis (T2N2bM1 disease) (Figure 5).
Time-line of case report 2.
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F6
In addition to Cr(VI) exposure, the patient may have come into contact with other chemical substances (Figure 6).