PMC2822249_01
Lymph node biopsy (H&E stain, x20). Microscopically, the mass exhibits diffuse effacement of lymph node architecture and granulomas. Inset is the enlarged picture (x200) of the area indicated by arrow.
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F1
Microscopically, the mass exhibited diffuse effacement of lymph node architecture and multiple granulomas (Fig. 1).
Lymph node biopsy (H&E stain, x200). Reed-Sternberg cells (solid arrow) are scattered among a background of many mature lympocytes. Arrow inside inset shows mitosis.
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F2
Many large atypical mononuclear or binuclear cells, including Reed-Sternberg cells, were scattered among many mature lymphocytes rare eosinophils, and plasma cells (Fig. 2).
Sural nerve biopsy (modified Gomori trichrome stain, x100). The sural nerve biopsy shows several myelin digestion chambers (arrow), suggesting axonal degeneration.
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F3
The sural nerve biopsy showed several myelin digestion chambers, suggesting axonal degeneration on modified Gomori stain (Fig. 3).
Sural nerve biopsy (EM findings, x7,000). The sural nerve shows loss of small and large myelinated fibers and degenerating axons with myelin ovoids (arrow), suggesting axonal neuropathy.
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F4
On electron microscopy, the sural nerve showed the loss of small and large myelinated fibers with axonal sprouting and myelin ovoids, suggesting an axonal neuropathy (Fig. 4).