PMC6604134_01
State-transition diagram for illness-death model. State-transition diagram for an illness-death model. The model consists of three health states: healthy (h), ill (i), and dead (d). Variable names adjacent to the solid arrows are transition rates (, , and ). This model is said to be "progressive" because transitions are irreversible (i.e. unidirectional). The curved arrows indicate that individuals can remain in a particular state over time. See text for more details
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PMC6604134_01_12962_2019_182_Fig1_HTML.jpg
Fig1
MESCC can be modelled as in Fig. 1 if we consider ability to ambulate as the healthy state h and the inability to ambulate due to neurologic dysfunction as the ill state i.
Comparison of state-membership fractions, RT-alone arm. State-membership fractions for RT-alone arm. Non-parametric multistate fractions, solid black line. Parametric multistate fractions based on true transition rates, small dashed red line
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PMC6604134_01_12962_2019_182_Fig2_HTML.jpg
Fig2
Plots comparing proper non-parametric multistate and proper parametric multistate fractions showed good agreement, and no evidence of systematic deviation (Figs. 2 and 3).
Comparison of state-membership fractions, mS+RT arm. State-membership fractions for arm. Non-parametric multistate fractions, solid black line. Parametric multistate fractions based on true transition rates, small dashed red line
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PMC6604134_01_12962_2019_182_Fig3_HTML.jpg
Fig3
Plots comparing proper non-parametric multistate and proper parametric multistate fractions showed good agreement, and no evidence of systematic deviation (Figs. 2 and 3).