PMC6308902_01
Active and resolving lesions of reactive perforating collagenosis after the third injection of ranibizumab. A) On the trunk, B) on the upper arm. Residual postinflammatory hyperpigmented macules are also seen at the site of prior lesions.
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F1
In dermatological examination, he had a generalized, erythematous rash with umblicated papules, many of which had ridge-like borders and some contained keratin plugs (Figure 1 (Fig. 1)).
Histopathological features of the reactive perforating collagenosis lesion in our case. A) Cup-shaped depression of the epidermis associated with a keratin plug containing compact ortho- and parakeratosis with granular nuclear debris (H&E). B) Altered collagen fibers in the underlying dermis, with focal extrusion through the epidermis (masson tricrome).
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F2
Altered collagen fibers were seen in the underlying dermis, with focal extrusion through the epidermis (Figure 2 (Fig. 2)).
Good anatomical and visual response to AFL injections after switching. A) The subretinal fluid and shallow PED are present at baseline (VA: 20/32). B) No subretinal fluid is seen after the third AFL injection on OCT at the last visit (VA: 20/25). . PED: Pigment epithelial detachment. VA: Visual acuity. OCT: Optic coherence tomography.
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F3
Final visual acuity was 20/25 and the central macular thickness was 189 microm (Figure 3 (Fig. 3)).