PMC3687196_01
Intraoral view showing buccal cortical expansion with ulceration on the palatal aspect
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F1
The premolars were slightly displaced and an ulcer was observed in the interdental region on the palatal aspect [Figure 1].
Orthopantomogram showing ill-defined radiolucent lesion i.r.t. right maxillary posterior region with displaced roots of the regional teeth
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F2
Orthopantomogram revealed a well-delineated, unilocular radiolucent lesion extending from the mesial aspect of 23-26 with divergence of roots of the regional teeth [Figure 2].
H and E stained section showing islands of clear cells in fibrous connective tissue stroma (x40)
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F3
Microscopically, sections stained with H and E revealed sheets and islands of large clear cells separated by a delicate fibrous connective tissue stroma [Figure 3].
H and E stained section showing islands of polygonal, clear cells with interspersed hyperchromatic, columnar cells having eosinophilic cytoplasm (x100), Inset: Nuclear palisading observed at the periphery of the island (x400)
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F4
In addition, the fibrous connective tissue stroma exhibited some areas of hyalinization, but no fibrous capsule was identified at the periphery of the tumor [Figure 4].
PAS-positive cytoplasmic granules. Inset: diastase sensitive granules (x400)
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F5
The abundant cytoplasm of the clear cells showed diastase sensitive Periodic Acid Schiff-positive granules, indicating intracytoplasmic glycogen deposition [Figure 5].
Mild cytokeratin (CK-8) immunoreactivity in the tumor islands (x400)
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F6
CK-8 [Figure 6]. CK-19 on the other hand showed moderate, diffuse, heterogeneous pattern of immunoreactivity in the tumor islands [Figure 7].
Moderate cytokeratin (CK-19) immunoreactivity (x400)
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F7
CK-8 [Figure 6]. CK-19 on the other hand showed moderate, diffuse, heterogeneous pattern of immunoreactivity in the tumor islands [Figure 7].
Vimentin immunoreactivity localized to the fibrous connective tissue stroma (x400)
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F8
Vimentin was strongly positive in the fibrous stromal component only [Figure 8].