PMC5366790_01
Lateral anterior border of the tongue showing a large ulcerated lesion with indurated borders.
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According to the patient the lesion has been growing for the last 5 months (Figure 1).
Excisional biopsy of the lesion.
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After an excisional biopsy the diagnosis was of coccidioidomycosis (Figure 2).
Chronic granulomatous inflammatory infiltrate, showing lymphocytes, plasma cells, and multinucleated giant cells containing spherical cytoplasmic inclusions corresponding to Coccidioides immitis (H&E; 200x).
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C. PAS staining highlighting various bodies of C. immitis in red color (PAS).
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C. Grocott staining confirming the presence of large bodies of C. immitis in black (Grocott).
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Immunohistochemistry showing granulomatous inflammation with predominance of macrophages and giant multinucleated cells positive for CD68, containing bodies of C. immitis (200x).
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