PMC9231430_01
Timeline of clinical events. Considering the day of admission as day 0, ctDNA BRAF variant was identified on day 5. Therapy was initiated the same day.
fonc-12-846187-g001.jpg
PMC9231430_01_fonc-12-846187-g001.jpg
f1
The patient's treatment events during admission are represented in Figure 1 (circle).
CT scan of abdomen showing innumerable lesions throughout the liver consistent with metastatic disease on day 1 on the left vs day 104 on the right with improved lesion sizes.
fonc-12-846187-g002.jpg
PMC9231430_01_fonc-12-846187-g002.jpg
f2
CT scan of the abdomen identified widespread metastatic disease in the liver, a 2.5 cm renal mass in left lower pole, and a non-specific sclerotic focus in the right ileum (Figure 2). CT scans of the abdomen/pelvis and chest showed significant response to the therapy as shown in Figures 2 and 3.
CT scan of chest showing dominant lingular mass concerning for primary lung cancer or metastatic lesion. Multiple bilateral small pulmonary nodules and T3 vertebral body destructive lesion seen concerning for metastatic disease on day 1 on the left vs on day 104 on the right showing decrease in sizes and numbers of pulmonary nodules suggestive of favorable treatment response.
fonc-12-846187-g003.jpg
PMC9231430_01_fonc-12-846187-g003.jpg
f3
CT scan of the chest identified a lingular mass (Figure 3), bilateral pulmonary nodules, and a destructive lesion in the T3 vertebral body. CT scans of the abdomen/pelvis and chest showed significant response to the therapy as shown in Figures 2 and 3.