PMC2804057_01
Serum time-concentration profile of quetiapine after ingestion of an assumed amount of 36 g Seroquel in a 32-year-old female patient. Solid-line: fitted line based on a two-compartment model assuming a reduced resorption. Dotted line: fitted line expected by population pharmacokinetic parameters and normal resorption.
CRM2009-371698.001.jpg
PMC2804057_01_CRM2009-371698.001.jpg
fig1
 Figure 1 exemplifies the obtained quetiapine concentration levels and the software generated time-concentration profile based on a two-compartment model (solid-line). Volume of distribution was within the expected range (Vd = 9 L/kg based on fitted solid line, Figure 1).