PMC3369260_01
Endoscopic examination. a First endoscopic examination: More than 100 yellowish plaques measuring 1-20 mm in diameter were seen in the middle and lower thoracic esophagus. The lobulated flower-like lesions were scattered over the mucosal surface. b Endoscopic examination after 1 year: The lesions had decreased slightly in size or number compared with the first examination. c Endoscopic examination after 2 years: The lesions had decreased further in size or number compared with the first examination. d Endoscopic examination after 3 years: The lesions had increased in size or number again and were similar to the first examination.
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F1
Endoscopic examination revealed more than 100 yellowish plaques 1-20 mm in diameter scattered over the mucosal surface of the middle and lower thoracic esophagus (fig. 1a). Repeat endoscopic examination at 1 and 2 years revealed that the lesions had decrease slightly in size or number compared with the first examination (fig. 1b, c). Endoscopic examination at 3 years revealed that the lesions had increased slightly in size or number compared with the preceding two examinations, to resemble the first endoscopy (fig. 1d).
Microscopic examination. a Squamous epithelium overlying the sebaceous glands (H&E, x10). b Lymphocytic infiltration is seen around the sebaceous glands (H&E, x100). c The excretory duct of a sebaceous gland is connected with the squamous epithelium (H&E, x100).
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F2
Biopsy specimens stained with hematoxylin-eosin (H&E) showed sebaceous glands associated with lymphocytic infiltration and an excretory duct, and overlying squamous epithelium (fig. 2).