PMC3322626_01
A red, dome-shaped nodule, 12 x 10 mm in size on the center of the nose.
cde-0004-0027-g01.jpg
PMC3322626_01_cde-0004-0027-g01.jpg
F1
On her initial visit, physical examination revealed a red, dome-shaped nodule, 12 x 10 mm in size on the center of her nose (fig. 1).
A dense lymphocytic infiltrate containing numerous histiocytes that surrounded and infiltrated hypertrophic hair follicles. The infiltrate is separated from the epidermis by a grenz zone. There was no reactive pattern to the follicular centers. (a). Infiltrated cells were medium-sized with a high nuclear/cytoplasmic ratio and prominent nucleoli (b). CD1a-positive cells were densely infiltrated around the hair follicle (c). Original magnification x50 (a, c), x200 (b).
cde-0004-0027-g02.jpg
PMC3322626_01_cde-0004-0027-g02.jpg
F2
A biopsy specimen showed a dense lymphocytic infiltrate containing numerous histiocytes that surrounded and infiltrated hypertrophic hair follicles (fig. 2a). The infiltrate is separated from the epidermis by a grenz zone (fig. 2a). There was no reactive pattern in follicular centers. (fig. 2a). Infiltrated cells were medium-sized with a high nuclear/cytoplasmic ratio and prominent nucleoli (fig. 2b). CD4+, CD5+ and CD8+) lymphocytes. CD1a-positive cells were densely infiltrated around the hair follicles (fig. 2c).