PMC6556623_01
Anterior view of the skin lesion diagnosed as Kaposi sarcoma and Molluscum contagiosum.
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F0001
He re-presented at our facility again with low CD4 count (98 cells per microL) and high viral load (> 10 000.00 copies/mL) and had developed progressive, generalized, asymmetrical, non-scaly, maculo-papular, hyperpigmented focally nodular cutaneous lesions involving the head, neck, trunk (anteriorly and posteriorly), and the proximal upper and lower limbs, especially on the medial surfaces with the largest nodule reaching 2.5 cm in diameter, over a period of 3 months (Figure 1 and Figure 2). He was on a first-line highly active antiretroviral therapy regimen (zidovudine/lamivudine/nevirapine) before defaulting.
Posterior view of the skin lesion diagnosed as Kaposi sarcoma and Molluscum contagiosum.
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F0002
He re-presented at our facility again with low CD4 count (98 cells per microL) and high viral load (> 10 000.00 copies/mL) and had developed progressive, generalized, asymmetrical, non-scaly, maculo-papular, hyperpigmented focally nodular cutaneous lesions involving the head, neck, trunk (anteriorly and posteriorly), and the proximal upper and lower limbs, especially on the medial surfaces with the largest nodule reaching 2.5 cm in diameter, over a period of 3 months (Figure 1 and Figure 2). He was on a first-line highly active antiretroviral therapy regimen (zidovudine/lamivudine/nevirapine) before defaulting.
Low power view of the coexisting Kaposi sarcoma (golden arrow) and Molluscum contagiosum (black arrow). Haematoxylin and eosin staining X 40.
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F0003
In another focus within the lesion was a lobular lesion composed of enlarged keratinocytes whose nuclei were distended by eosinophilic amorphous bodies, consistent with molluscum bodies (Figure 3 and Figure 4).
(a) Section showing a lobular lesion composed of enlarged keratinocytes with central eosinophilic molluscum bodies. (b) Section showing plump spindle cells with bland nuclei delimiting slit-like vascular spaces, consistent with Kaposi sarcoma. Haematoxylin and eosin staining X 200.
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F0004
In another focus within the lesion was a lobular lesion composed of enlarged keratinocytes whose nuclei were distended by eosinophilic amorphous bodies, consistent with molluscum bodies (Figure 3 and Figure 4).