PMC5890303_01
Three incremental outcomes consistent with a positive net benefit.. The cost-effectiveness plane illustrates the incremental costs (Y-axis) and incremental consequences (X-axis) between a new health technology (for example, a precision medicine) and a relevant comparator (for example, current practice). The dashed line through the origin of the plane represents the cost-effectiveness threshold. Incremental outcomes that are below the dashed line graphically have a positive incremental net health benefit (see accompanying table). The figure illustrates that different combinations of incremental outcomes are possible for a precision medicine to be a relatively cost-effective use of health care resources.
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Several published model-based cost-effectiveness analyses concluded that TPMT testing, to inform azathioprine prescribing decisions, was a dominant intervention (see Figure 1) that produced more health benefit at a lower cost compared with not testing.
PMC5890303_02