PMC9946693_01
The pigmented nodular and blackish tumor with a pedunculated and infiltrated base measuring 4 cm.
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FIG1
On clinical examination, we found a nodular and blackish tumor of firm consistency with a pedunculated and infiltrated base measuring 4 cm (Figure 1).
Dermoscopy reveals a chaotic pattern with a blue-white veil and tree-trunk vascular pattern.
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FIG2
Dermoscopy revealed a chaotic pattern with a blue-white veil and tree-trunk vascular pattern (Figure 2).
Histological examination shows an ulcerated skin lesion whose dermis contains a biphasic, basaloid, and pigmented tumor (hematoxylin-eosin-saffron x100).
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FIG3
Optical microscopic examination showed an ulcerated skin lesion whose dermis contained a pigmented tumor arranged in lobules and sheets without connection with the epidermis (Figures 3, 4).
Histological examination shows adermal biphasic, basaloid, and pigmented tumor arranged in lobules and sheets without connection with the epidermis (hematoxylin-eosin-saffron x100).
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FIG4
Optical microscopic examination showed an ulcerated skin lesion whose dermis contained a pigmented tumor arranged in lobules and sheets without connection with the epidermis (Figures 3, 4).
Epithelial tumor cells are basaloid, with a pleomorphic nucleus, prominent nucleolus, and basophilic-reduced cytoplasm. Atypical mitotic figures are noted (hematoxylin-eosin-saffron x400).
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FIG5
Numerous mitotic figures were noted with atypical ones (22 mitoses/2 mm2) (Figure 5).
Epithelial basaloid cells are mixed with numerous heavily pigmented dendritic melanocytes (hematoxylin-eosin-saffron x200).
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FIG6
These cells were mixed with numerous heavily pigmented dendritic melanocytes (Figure 6).
Clusters of ghost cells are noted (hematoxylin-eosin-saffron x400).
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FIG7
Clusters of ghost cells (Figure 7) were noted along with foci of necrosis.
Cytoplasmic positive immunostaining by cytokeratin AE1/AE3 on epithelial tumoral cells (x200).
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FIG8
On immunohistochemical analysis, tumor cells expressed cytokeratin AE1/AE3 (Figure 8), p63 (Figure 9), and beta-catenin (nuclear and cytoplasmic staining) (Figure 10), while melanin markers (Melan A and HMB45) highlight non-atypical dendritic melanocytes (Figure 11).
Nuclear positive immunostaining by p63 on epithelial tumoral cells (x200).
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FIG9
On immunohistochemical analysis, tumor cells expressed cytokeratin AE1/AE3 (Figure 8), p63 (Figure 9), and beta-catenin (nuclear and cytoplasmic staining) (Figure 10), while melanin markers (Melan A and HMB45) highlight non-atypical dendritic melanocytes (Figure 11).
Strong nuclear and cytoplasmic positive immunostaining by beta-catenin on epithelial tumoral cells (x200).
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FIG10
On immunohistochemical analysis, tumor cells expressed cytokeratin AE1/AE3 (Figure 8), p63 (Figure 9), and beta-catenin (nuclear and cytoplasmic staining) (Figure 10), while melanin markers (Melan A and HMB45) highlight non-atypical dendritic melanocytes (Figure 11).
Melanin markers (Melan A and HMB45) highlight non-atypical dendritic melanocytes (x200).
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FIG11
On immunohistochemical analysis, tumor cells expressed cytokeratin AE1/AE3 (Figure 8), p63 (Figure 9), and beta-catenin (nuclear and cytoplasmic staining) (Figure 10), while melanin markers (Melan A and HMB45) highlight non-atypical dendritic melanocytes (Figure 11).