PMC6103232_01
Primary tumour of the breast formed by uniform cells with scant, lightly eosinophilic cytoplasm, arranged in broad gyriform trabeculae. Invasive component is visible at the top, in situ component below it (H&E, 20x)
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Histopathological examination of the breast tumour specimen confirmed a primary neuroendocrine carcinoma of the breast (a well-differentiated neuroendocrine neoplasm - WD-NEN) with vascular invasion (Fig. 1) and the following immunophenotypes: synaptophysin+ (Fig. 2), chromogranin+, Ki67 3%, ER: 60%, PR 80%, and HER2-0.
Liver metastasis of the neuroendocrine tumor, composed by monomorphic cells arranged in trabeculae (H&E, 20x)
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The liver tumour specimen also revealed a neuroendocrine tumour (Fig. 3) with the following immunohistochemical characteristics: synaptophysin+ (Fig. 4), chromogranin+ (Fig. 5), GATA3+ (Fig. 6), HepPar1-, Glypican3-, Ki67 of 12%, ER 40% (Fig. 7), PR 0%, and HER2-0.
Chromogranin A expression in cells of the metastatic tumour of the liver (20x)
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The liver tumour specimen also revealed a neuroendocrine tumour (Fig. 3) with the following immunohistochemical characteristics: synaptophysin+ (Fig. 4), chromogranin+ (Fig. 5), GATA3+ (Fig. 6), HepPar1-, Glypican3-, Ki67 of 12%, ER 40% (Fig. 7), PR 0%, and HER2-0.
ER expression in cells of the metastatic tumour of the liver (20x)
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The liver tumour specimen also revealed a neuroendocrine tumour (Fig. 3) with the following immunohistochemical characteristics: synaptophysin+ (Fig. 4), chromogranin+ (Fig. 5), GATA3+ (Fig. 6), HepPar1-, Glypican3-, Ki67 of 12%, ER 40% (Fig. 7), PR 0%, and HER2-0.