PMC10064861_01
Anatomical lesion, structural disconnection map and metabolic asymmetry. (A) Anatomical lesion and associated structural disconnection map. T1-weighted structural MRI scan showing the anatomical lesion (red) in the midline frontal structures and the associated structural disconnection (blue) extending posteriorly and contralaterally (FST, fronto-striatal tract; ATP, anterior thalamic projection; OR, optic radiation; FAT, fronto-aslant tract; SFG, superior frontal gyrus; CC, corpus callosum). (B)
Structural disconnection and metabolic asymmetry. T1-weighted structural MRI scan showing the structural disconnection (blue, threshold 20%) and regions with significative metabolic asymmetry (>2SD; green; SFG, medial orbital gyrus (MOG), caudate, putamen, thalamus (T), posterior cingulate cortex (PCC), cuneus, lingual gyrus).
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Brain MRI after surgery showed post-surgical damage in the right frontal lobe (Supplementary Figure S1).
Resting state networks functional connectivity analysis. Top: Spatial pattern of representative altered resting state networks. VIS (A,B), DMN (C,D), DAN (E), and FPN (F). In each panel resting state network spatial pattern is reported for the group of healthy subjects and for the patient, respectively in the upper and lower part of the panel. Bottom: Functional connectivity between resting state networks. Average across the healthy group is shown in panel A, patient's connectivity in panel B, and patient's altered connections in panel C.
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There was bilateral slowing on the EEG during delirium (Supplementary Figure S2).