PMC4153184_01
Chest CT-scan of the patient before chemotherapy
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Chest CT-scan revealed a mass in the visceral mediastinum extending to the right main and lobar bronchi (Figure 1).
Hematoxylin and eosin staining (x400) of the lung biopsy specimen
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Histologically, a section from the bronchial mucosa showed a neoplastic growth comprising a nest of small-to-medium-sized cells with hyperchromatic nuclei, scant cytoplasm, and foci of necrosis (Figure 2).
Immunohistochemical staining (neuron-specific enolase) of the lung biopsy specimen
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Tumor cells were focally positive for creatine kinase (CK) and strongly positive for neuron-specific enolase (NSE) (Figure 3).
Chest CT of the patient after chemotherapy
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Chest CT at six-month follow-up showed a significant improvement (Figure 4).