PMC8256239_01
CT Imaging of oropharyngeal area. Well-limited formation along the posterior part of
the oropharynx, behind the uvula from which it is inseparable, measuring
21 mm x 9 mm x 20 mm. No signs of infiltration and penetration through the oropharyngeal
wall are seen.
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No signs of infiltration to prevertebral tissue nor progression to parapharyngeal or retropharyngeal space were seen (Figure 1).
Gross pathological sample of tumor. Elevated, partially ulcerated nodul, approximately
2 cm in diameter, in the mucosa of 83-year-old man.
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Macroscopic examination of the excised tissue revealed a mucosal sample with ulcerative nodule, measuring 2.5 cm x 2 cm x 1 cm (Figure 2).
Microscopic pathological slides of tumor. Undifferentiated pleomorphic sarcoma in
oropharyngeal mucosa of an 83 year-old man. Elevated nodul composed of pleomorphic,
mostly spindle-shaped cells with some intervening collagen covered with normal squamous
epithelium (a). On higher magnification a polymorphic cells, an atypical epitheloid
tumor cells with large, vesicular, and hyperchromatic nuclei, with atypical mitosis and
occasional tumor multinuclear giant cells (b). Well delineated nodul on the base of
tumor in lamina propria with sparing the muscular layer (c). By immunohistochemistry
tumor cells were negative with epithelia marker (pan cytokeratin, AE1/AE3) (d), focally
positive with CD68 (e), and strongly positive for CD10 (f).
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The tumor was strongly diffuse positive for Vimentin and CD10, focally positive for CD68, CD99, and Bcl-2, and negative for all other markers (Figure 3).