PMC6537289_01
Histopathology of vitamin C deficiency-associated megaloblastic anemia. (A)
Macrocytic red blood cells on peripheral blood smear (x1000). (B) Bone
marrow biopsy shows hyperplastic marrow with megaloblastic erythroid and
myeloid precursors (x400). (C) Megaloblastic erythroid and myeloid
precursors on marrow aspirate smear (x1000). (D) Moderate amount of iron
storage in spicules, iron staining (x400).
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PMC6537289_01_10.1177_1179547619849036-fig1.jpg
fig1-1179547619849036
Peripheral blood smear showed macrocytes (Figure 1A), mild anisocytosis, and rare nucleated RBCs. The biopsy showed hypercellular marrow for age (90%) with trilineage hematopoiesis (Figure 1B). There was absolute erythroid hyperplasia and megaloblastic change (Figure 1B and C). The iron stain revealed abundant amount of iron storage (Figure 1D), and retic stain revealed no increase in reticulin fibers.