PMC6484211_01
MRI findings of CNS-PTLD and histopathological features of CNS-PTLD.. Axial gadolinium-enhanced T1-weighted imaging (A), and fluid-attenuated inversion recovery (FLAIR) on magnetic resonance images (MRI) (B). MRI showed an approximately 20-mm ring-enhanced lesion in the left front-parietal lobe with perifocal edema.. Cerebral biopsy showed extensive necrosis (C; H&E stain, x100) and the infiltration of large atypical lymphocytes (D; H&E stain, x400). Atypical cells were positive for CD20 (E; x400). A small number of Epstein-Barr virus (EBV)-encoded small RNA-positive cells were detected (F: x600).
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Magnetic resonance imaging (MRI) of the brain revealed a space-occupying lesion with ring enhancement and perifocal edema in the left front-parietal lobe (Fig. 1A, B), indicating several differential diagnoses, including opportunistic infections, PTLD, and the extramedullary relapse of ALL. A small number of EBV-encoded small RNA (EBER)-positive cells were detected (Fig. 1C-F).