PMC5300744_01
Neuropsychologic testing. All raw scores were converted to scaled scores based on Mayo Older American Normative Studies (MOANS) norms (mean, 10; SD, 3). DRS-Dementia rating scale; AVLT-delay indicates retention on the Auditory Verbal Learning Test; BNT, Boston Naming Test; COWAT, Controlled Oral Word Association Test; JLO, Judgment of Line Orientation; Rey-O, Rey-Osterrieth Complex Figure Test; TMT, Trail Making Test; WAIS-BD, Block Design subtest of the Wechsler Adult Intelligence Scale-Revised; WMS-LM, Logical Memory of the Wechsler Memory Scale-Revised; Stroop CW, Stroop color-word test.
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F1
Her last completed neuropsychometric evaluation (Figure 1) occurred at age 71.
Histopathology demonstrating globular glial tauopathy. Histopathology: Globular glial tauopathy, type I, with 4R tau positive globular glial inclusions, predominantly oligodendroglial and to a lesser extent astrocytic. The Gallyas stain was positive in oligodendroglial and negative in astrocytic lesions, as is typical of GGT. There were no TDP43-positive inclusions.. a. Temporal white matter (H&E, x200; inset x750). b. Temporal white matter (Gallyas, x200; inset x750). c. Temporal white matter (phospho-tau (AT8), x200). d. Temporal white matter (4R tau,x200). e. Temporal gray matter (phospho-tau (AT8), x200; inset: 4R tau x400). f. Temporal gray matter (Gallyas, x200)
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F2
Histopathologic features are illustrated in Figure 2.