PMC8476878_01
A solid, poorly vascularized mass, measuring 83 x63 x36 mm, with thin septa, is apparent in the rectus muscle of the abdomen in the suprapubic area (arrow).
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F1
Computed tomography (CT) revealed evidence of a solid, poorly vascularized, partially cystic neoformation, with thin septa, localized in the left lower rectus muscle, with no other noteworthy findings (Figure 1).
Histological images of the tumor. Carcinoma with papillary and tubule-cystic architecture. The cells exhibit clear and eosinophilic cytoplasm and hyperchromatic nuclei with mild to moderate atypia (arrow) (A; H&E, 5x). Dilated cysts lined by flattened cells with benign-appearing nuclei intermixed with atypical papillae (arrow) (B; H&E, 10x). Occasional small groups of clear cells (arrow) (C; H&E, 10x). Irregular infiltrating glands with dense fibrous stroma (arrow) (D; H&E, 10x).
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F2
The cells exhibited clear and eosinophilic cytoplasm and hyperchromatic nuclei with mild to moderate atypia (Figure 2A). Moreover, intermixed with atypical papillae, dilated cysts lined by flattened cells with benign-appearing nuclei were observed (Figure 2B). Occasional small groups of clear cells were observed (Figure 2C). No foci of benign endometrial glands were found; however, dense fibrous tissue and hemorrhagic areas were present mainly in the peripheral area of the lesion (Figure 2D).
Immunohistochemical profile: diffuse expression of ARID1A (A, 20x), CK7 (B; 20x); napsin-A (C, 20x), and PAX8 (D; 20x).
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F3
Immunohistochemical analysis revealed expression of CK7, PAX8, napsin-A, ARID1A, and membranous beta-catenin (Figure 3) in neoplastic cells, and negativity for ER, PR, CA125, CDX2, TTF1 and calretinin.