PMC10174310_01
(A) The score of neuropsychological scale. The patient's depression and anxiety scores, are decreasing. The scores for cognitive, dysfunction are increasing year by year. (B) The score of each cognitive domain in MOCA. Visuospatial/executive function, delayed memory, attention, and orientation are declined year to year. (C) Time line.
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fig1
The improvement in the patient's depression and anxiety symptoms after treatment can be seen in Figure 1A. Figure 1B shows a year-to-year decline in visuospatial/executive function, delayed memory, attention, and orientation in.
(A) The brain volume changes in regions of interest. The patient's hippocampal, amygdala, occipital, temporal, and insula brain area volumes have gradually decreased over the last 3 years. (B) MRI results ((1)-(9)). (1) 2014.12 Coronal T2. (2) 2017.7 Coronal T2. (3) 2018.3 Coronal T2. (4) 2014.12 Coronal T1. (5) 2017.7 Coronal T1. (6) 2018.3 Coronal T1. (7) 2020.11 Coronal T2. (8) 2022.3 Coronal T1. (9) 2023.2 Coronal T1. (1)-(6) No significant atrophy in the hippocampal region. (7)-(9) The degree of brain atrophy gradually increased.
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fig2
As shown in Figure 2A, the patient's hippocampal, amygdala, occipital, temporal, and insula brain area volumes have gradually decreased over the last 3 years, consistent with the literature. In Figure 2B(1)-(3), the visual analysis of the coronal scan showed no significant atrophy in the hippocampal region of the patient. As shown in Figure 2B(4)-(6), the patient did not show any significant signs of brain atrophy on MRI follow-up from 2014.12 to 2018.3. As shown in Figure 2B(7)-(9), the patient's MRI from 2020.3 to 2023.2 showed signs of brain atrophy, and the degree of atrophy gradually increased.
(A) (1) The 3D T1 MRI. (2) the image 18F-FDG PET fused with MRI. (2) Showed hypometabolism in the parietal, temporal, and posterior cingulate gyrus. (B) (3) The 3D T1 MRI. (4) The image 18F-AV45 PET fused with MRI. (4) Showed significant cortical Abeta deposition.
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fig3
In Figure 2B(1)-(3), the visual analysis of the coronal scan showed no significant atrophy in the hippocampal region of the patient. As shown in Figure 2B(4)-(6), the patient did not show any significant signs of brain atrophy on MRI follow-up from 2014.12 to 2018.3. As shown in Figure 2B(7)-(9), the patient's MRI from 2020.3 to 2023.2 showed signs of brain atrophy, and the degree of atrophy gradually increased. The MRI structural imaging showed hippocampal and cortical atrophy, 18F-FDG imaging suggested hypometabolism in the parietal, temporal, and posterior cingulate gyrus (Figure 3A), and 18F-AV45 imaging suggested significant cortical Abeta deposition (Figure 3B), which is consistent with the imaging manifestations of Alzheimer's disease.