PMC5660978_01
Representative T2 FLAIR MR images highlighting hemispheric atrophy over time. Patient 1 (top panel) showed left frontal predominant atrophy over a 2-year period; axial sections. Patient 2 (middle panel) displayed focal left frontal atrophy over an 18-month period; coronal sections. Patient 3 (bottom panel) had profound right cortical atrophy over a 7-year period; axial sections. MR images were obtained on machines using a 3-T magnet.
fneur-08-00564-g001.jpg
PMC5660978_03_fneur-08-00564-g001.jpg
F1
Many right temporal seizures (clinical semiology of paresthesias over left face and arm) were observed and the interictal EEG was notable for right periodic lateralized discharges (PLDs; Figure 1). MR imaging performed showed marked right hemisphere volume loss, affecting both gray and white mater (Figure 1).
Representative ictal and interictal EEGs. Patient 1 (top panel) displayed left frontal seizures with accompanying right arm and face twitching consistent with epilepsia partialis continua (7/14) and focal interictal slowing (10/14). Later, left occipital seizures (1/16) were also observed. Patient 2 (middle panel) also had left frontal seizures (9/13) and focal interictal slowing (12/16). Patient 3 (bottom panel) had right hemispheric seizures (9/07) with focal interictal slowing (2/10) early in the disease course and developed left sided seizures (11/15) in later stages. EEGs arranged in longitudinal bipolar configuration with sensitivity of 7 muV/mm.
fneur-08-00564-g002.jpg
PMC5660978_03_fneur-08-00564-g002.jpg
F2
Despite the marked asymmetry on imaging findings, EEG monitoring during this advanced stage of disease revealed bihemispheric electrographic pathology; in addition to PLDs in the right posterior quadrant, PLDs and spikes were observed over the left temporal region as well as bilateral independent frontal spikes (Figure 2).
PMC5660978_02
Representative T2 FLAIR MR images highlighting hemispheric atrophy over time. Patient 1 (top panel) showed left frontal predominant atrophy over a 2-year period; axial sections. Patient 2 (middle panel) displayed focal left frontal atrophy over an 18-month period; coronal sections. Patient 3 (bottom panel) had profound right cortical atrophy over a 7-year period; axial sections. MR images were obtained on machines using a 3-T magnet.
fneur-08-00564-g001.jpg
PMC5660978_03_fneur-08-00564-g001.jpg
F1
Many right temporal seizures (clinical semiology of paresthesias over left face and arm) were observed and the interictal EEG was notable for right periodic lateralized discharges (PLDs; Figure 1). MR imaging performed showed marked right hemisphere volume loss, affecting both gray and white mater (Figure 1).
Representative ictal and interictal EEGs. Patient 1 (top panel) displayed left frontal seizures with accompanying right arm and face twitching consistent with epilepsia partialis continua (7/14) and focal interictal slowing (10/14). Later, left occipital seizures (1/16) were also observed. Patient 2 (middle panel) also had left frontal seizures (9/13) and focal interictal slowing (12/16). Patient 3 (bottom panel) had right hemispheric seizures (9/07) with focal interictal slowing (2/10) early in the disease course and developed left sided seizures (11/15) in later stages. EEGs arranged in longitudinal bipolar configuration with sensitivity of 7 muV/mm.
fneur-08-00564-g002.jpg
PMC5660978_03_fneur-08-00564-g002.jpg
F2
Despite the marked asymmetry on imaging findings, EEG monitoring during this advanced stage of disease revealed bihemispheric electrographic pathology; in addition to PLDs in the right posterior quadrant, PLDs and spikes were observed over the left temporal region as well as bilateral independent frontal spikes (Figure 2).
PMC5660978_03
Representative T2 FLAIR MR images highlighting hemispheric atrophy over time. Patient 1 (top panel) showed left frontal predominant atrophy over a 2-year period; axial sections. Patient 2 (middle panel) displayed focal left frontal atrophy over an 18-month period; coronal sections. Patient 3 (bottom panel) had profound right cortical atrophy over a 7-year period; axial sections. MR images were obtained on machines using a 3-T magnet.
fneur-08-00564-g001.jpg
PMC5660978_03_fneur-08-00564-g001.jpg
F1
Many right temporal seizures (clinical semiology of paresthesias over left face and arm) were observed and the interictal EEG was notable for right periodic lateralized discharges (PLDs; Figure 1). MR imaging performed showed marked right hemisphere volume loss, affecting both gray and white mater (Figure 1).
Representative ictal and interictal EEGs. Patient 1 (top panel) displayed left frontal seizures with accompanying right arm and face twitching consistent with epilepsia partialis continua (7/14) and focal interictal slowing (10/14). Later, left occipital seizures (1/16) were also observed. Patient 2 (middle panel) also had left frontal seizures (9/13) and focal interictal slowing (12/16). Patient 3 (bottom panel) had right hemispheric seizures (9/07) with focal interictal slowing (2/10) early in the disease course and developed left sided seizures (11/15) in later stages. EEGs arranged in longitudinal bipolar configuration with sensitivity of 7 muV/mm.
fneur-08-00564-g002.jpg
PMC5660978_03_fneur-08-00564-g002.jpg
F2
Despite the marked asymmetry on imaging findings, EEG monitoring during this advanced stage of disease revealed bihemispheric electrographic pathology; in addition to PLDs in the right posterior quadrant, PLDs and spikes were observed over the left temporal region as well as bilateral independent frontal spikes (Figure 2).