PMC5513338_01
Schematic representation of activated partial thromboplastin time (APTT), platelet count and key anticoagulation management interventions following cardiovascular surgery. BID twice daily, DVT deep vein thrombosis, po by mouth, PTT partial thromboplastin time, SC subcutaneous administration, tid three times daily, UFH unfractionated heparin
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Fig1
Following the expected early postoperative thrombocytopenia, the patient developed an unexpected further decline in the platelet count that began on POD 5, with further progression in thrombocytopenia resulting in an ultimate platelet count nadir of 16 x 109/L on POD 10 (see Fig. 1). The patient was continued on argatroban for 16 days with minimal improvement in platelet count (Fig. 1).