PMC9872134_01
Clinical presentation at the recruitment: frontal view (A) and lateral view (B).
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Clinical examination revealed swelling, erythema, palpable mass, and peau d'orange on the left breast ( Figures 1A, B ).
Fine needle cytology: neoplastic proliferation of large round cells with pleomorphic nuclei, negative for epithelial marker CK (A) and positive for linfoid marker and vimentin (B).
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The following percutaneous biopsy of the mass demonstrated a proliferation of phenotypically aberrant population of large cells that expressed CD30 and CD45, negative for CD3, CD20, and ALK1, diagnostic for anaplastic large cell lymphoma, ALK-negative (ALK-ALCL) ( Figures 2A, B ).
Clinical response after chemotherapy: frontal view (A) and lateral view (B).
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Afterwards, a consolidation treatment with ASCT after BEAM conditioning regimen (BCNU, etoposide, cytarabine, and melphalan) was finally performed ( Figures 3A, B ).
Surgical specimen: implants with total en bloc capsulectomy (A) and periprosthetic tissue previously involved by BIA-ALCL (B).
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On the left, the site of the periprosthetic mass was also removed ( Figures 4A, B ).
Complete pathological response: histology does not show neoplastic cells with a polyurethane crystal and rare inflammatory cells (A), flat synovial metaplasia, and foreign body giant cell granulomas (B).
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The histology, performed as reported by Lyapichev et al., revealed a complete pathologic response with CD30 immunohistochemistry negative ( Figures 5A, B ).