PMC3458411_01
Malignant components in the teratoma. (a) Benign large bowel component of mature cystic teratoma. (b) Strumal carcinoid, strongly positive for synaptophysin stain (inset); (c) follicular variant of papillary thyroid carcinoma with positive nuclear staining for TTF1 (inset). (d) Infiltrating mucinous adenocarcinoma.
CRIM.OBGYN2012-269489.001.jpg
PMC3458411_01_CRIM.OBGYN2012-269489.001.jpg
fig1
The mature cystic teratoma components consist of skin, cartilage, benign colonic, and thyroid tissues (Figure 1(a)). The malignant components consist of (1) well differentiated strumal carcinoid tumor confirmed with positive immunohistochemistry (IHC) for synaptophysin (Figure 1(b)), (2) well differentiated follicular variant of papillary thyroid carcinoma arising in struma ovarii tested positive for Thyroid Transcription Factor 1 (TTF1) (Figure 1(c)), Thyroglobulin and Cytokeratin 7 (CK7) by IHC, and (3) moderately differentiated mucinous adenocarcinoma arising in intestinal type mucinous cystadenoma (Figure 1(d)) which tested negative for CK7, negative for CDX2 and positive for CK20 by IHC.