PMC9396293_01
(A-H) Graphic summary of the case. The top line presents sequential CT images on mediastinal window (A, C, E, G) demonstrating the tumor volume regression during the treatment period (Dec 2020-May 2021-Sept 2021-Dec 2021). The bottom line presents images on lung window (B, D, F, H) from the same CT examinations demonstrating the evolution of the interstitial lung abnormalities in the course of the treatment strategy changes (Dec.2020-May 2021-Sept 2021-Dec 2021).
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Initial chest computed tomography (CT) (performed on 12/29/2020;  Figures 1A, B ) revealed bilateral supraclavicular, right axillary, and mediastinal lymphadenopathy. CT reevaluation (performed on 05/21/2021;  Figures 1C, D ) revealed a partial regression in the number and dimensions of the mediastinal, axillary, and supraclavicular lymph nodes. A follow-up CT scan (performed on 09/23/2021; Figures 1E, F) showed a positive response for both IPF and lung cancer, with a reduction in the size and number of mediastinal lymph nodes, and a substantial reduction in the consolidation zones with a partial response. A follow-up CT (performed on 12/18/2021;  Figures 1G, H ) revealed stable disease, with persistent enlarged right axillary lymph nodes, mediastinal lymph nodes, and interstitial fibrosis type UIP.