PMC8841721_01
Pedigree structure of the family with immunoglobulin A (IgA) nephropathy (IgAN). There were 47 individuals in the Chinese six-generation IgA pedigree with no close relatives that were married. The arrow indicates the proband, black-filled shapes indicate abnormal proteinuria and/or hematuria results, red-filled shapes indicate patients diagnosed as IgAN, and unfilled shapes indicate unaffected individuals.
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F1
The proband was a 28-year-old Chinese woman (V-6) (Figure 1).
Pathology presentation of patients V-6 and IV-5. (A) Patient V-6: light microscopy showed segmental sclerosis and podocyte hypertrophy (yellow arrow), by periodic acid-silver methenamine (PASM) staining; original magnification: 200X. (B) Patient IV-5: light microscopy showed segmental adhesion and podocyte hypertrophy (yellow arrow; PASM staining, 100X).
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F2
Light microscopy revealed mesangial hypercellularity, segmental adhesion, and podocyte hypertrophy (Figure 2B).
PMC8841721_02
Pathology presentation of patients V-6 and IV-5. (A) Patient V-6: light microscopy showed segmental sclerosis and podocyte hypertrophy (yellow arrow), by periodic acid-silver methenamine (PASM) staining; original magnification: 200X. (B) Patient IV-5: light microscopy showed segmental adhesion and podocyte hypertrophy (yellow arrow; PASM staining, 100X).
fmed-08-810940-g0002.jpg
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F2
Light microscopy revealed mesangial hypercellularity, segmental adhesion, and podocyte hypertrophy (Figure 2B).
PMC8841721_03