PMC7728125_01
Hematoxylin-Eosin (HE) staining (x100) shows the histological features of angiosarcoma, with normal tissue of the thyroid gland in the peripheral edge and areas with large epithelioid cells.
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F1
The histopathological (HP) assessment showed malignant proliferation characterized by epithelioid, large rounded cells with relatively high nuclear grade (Figure 1).
HE staining (x200) highlights tumor cells with eosinophilic cytoplasm and large, vesicular nuclei with prominent nucleoli. Numerous atypical mitoses are present
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F2
Atypical mitoses were present (Figure 2).
HE staining (x400) shows numerous vascular channels bordered by the epithelioid cells
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F3
Moreover, the cells grow in sheets and lined abnormal vascular spaces that contained erythrocytes (Figures 3 and 4).
Silver staining (x200) shows the vasoformation architecture
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F4
Moreover, the cells grow in sheets and lined abnormal vascular spaces that contained erythrocytes (Figures 3 and 4).
Immunohistochemical staining (x100) shows strong diffuse immunoreactivity for anti-CD31 antibody. CD31: Cluster of differentiation 31
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F5
Regarding the immunohistochemical profile, the neoplastic cells were strongly positive for CD31 (Figure 5), erythroblast transformation-specific related gene (ERG) (Figure 6) and CD34.
Immunohistochemical staining (x100) shows strong immunoreactivity for anti-ERG antibody. ERG: Erythroblast transformation-specific related gene
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F6
Regarding the immunohistochemical profile, the neoplastic cells were strongly positive for CD31 (Figure 5), erythroblast transformation-specific related gene (ERG) (Figure 6) and CD34.