PMC3861586_01
(A) In case 1, the normal breast structure was destroyed. At the edge of tumor, tumor cells were compressed by massive fibrous tissue into a streamline alignment. (B) Immunohistochemistry stain showing that MPO was markedly positive in the cell plasmid. (Hematoxylin and eosin staining; magnification, x200).
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At the edge of the tumor, the tumor cells exhibited a streamline alignment (Fig. 1A) and mitotic figures were easily identified. The immunohistochemical analysis showed that markers of myeloperoxidase (MPO) and CD45RA were positive and those for carcinoembryonic antigen (CEA), L26 and CD3 were negative, while CD45RO was weakly positive (Fig. 1B).
PMC3861586_02
(A) In case 2, mesenchymal tissues were packed into the tumor cells, arranged into a line and the fatty tissue was infiltrated at the edge of the tumor. (B) Immunohistochemistry stain showing that MPO was markedly positive in the cell plasmid. (Hematoxylin and eosin staining; magnification, x200).
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The tumor was removed in November, 2006, and the pathological results revealed that the structure of the breast, which had been invaded by middle-sized diffuse lymphoid cells and fat tissue, was destroyed (Fig. 2A). Immunohistochemical analysis revealed that the markers of MPO and LCA were positive and that those for CD68, CD79a and L26 were negative (Fig. 2B).