PMC3342738_01
Representative CT cuts from patients 1-4 demonstrating interstitial changes with reticular ground-glass opacities predominantly in the lower lobes.
PC-2-101-g001.jpg
PMC3342738_02_PC-2-101-g001.jpg
F1
Chest CT imaging revealed subtle, diffuse reticular opacities without traction bronchiectasis or honeycombing (Fig. 1). There was also moderate mediastinal adenopathy up to 22 mm. in maximal diameter (Fig. 1).
PMC3342738_02
Representative CT cuts from patients 1-4 demonstrating interstitial changes with reticular ground-glass opacities predominantly in the lower lobes.
PC-2-101-g001.jpg
PMC3342738_02_PC-2-101-g001.jpg
F1
Chest CT imaging revealed subtle, diffuse reticular opacities without traction bronchiectasis or honeycombing (Fig. 1). There was also moderate mediastinal adenopathy up to 22 mm. in maximal diameter (Fig. 1).
Representative pathology. (A) Uniform interstitial fibrosis and mild chronic inflammation characteristic of fibrotic NSIP (H and E, x4). (B) CD34 (x20) and (C) CD31 stains demonstrate subintimal proliferation by non-endothelial cells (x20). (D) H and E staining (x10) and (E) Movat staining (x20) demonstrate arterial medial hypertrophy with eccentric intimal proliferation. (F) Medial thickening and subintimal proliferation consisting of smooth muscle cells (smooth muscle actin stain, x20). (G) Concentric intimal proliferation (H and E, x20). (H) Venous muscularization (Movat statin, x20).
PC-2-101-g003.jpg
PMC3342738_02_PC-2-101-g003.jpg
F2
Lung pathology of all 4 patients demonstrated interstitial fibrosis and mild chronic inflammation characteristic of fibrotic NSIP (Fig. 2).