PMC3117631_01
Juvenile xanthogranuloma. Foamy histiocytes aggregates with classic teuton giant cells embedded.
cmo-1-2011-157f1.jpg
PMC3117631_01_cmo-1-2011-157f1.jpg
f1-cmo-1-2011-157
Focal areas showed significant hemosiderin deposits (Figure 1-3).
Note focally prominent hemosiderin deposit and presence of rare eosinophils.
cmo-1-2011-157f2.jpg
PMC3117631_01_cmo-1-2011-157f2.jpg
f2-cmo-1-2011-157
Focal areas showed significant hemosiderin deposits (Figure 1-3).
Teuton giant cell morphology is best appreciated on touch prep slides.
cmo-1-2011-157f3.jpg
PMC3117631_01_cmo-1-2011-157f3.jpg
f3-cmo-1-2011-157
Focal areas showed significant hemosiderin deposits (Figure 1-3).
The immunohistochemistry staining pattern: (A) Fascin upper left (B) CD68 upper right (C) CD4 lower left (D) Factor XIIIa lower right.
cmo-1-2011-157f4.jpg
PMC3117631_01_cmo-1-2011-157f4.jpg
f4-cmo-1-2011-157
Additional stains included: CD34, CD35, CD21, and CD20 negative; CD4 positive membranous; factor XIIIa strong positive; fascin positive; and cytoplasmic (Figure 4).
The liver ultrasound image showed multiple hypoechoic lesions.
cmo-1-2011-157f5.jpg
PMC3117631_01_cmo-1-2011-157f5.jpg
f5-cmo-1-2011-157
Diagnostic workup with abdominal ultrasound initially showed hepatomegaly with multiple hypoechoic lesions in the liver along with splenomegaly and ascites (Figure 5).
PMC3117631_02