PMC5841938_01
Whole blood HHV-6 titers and total leucocyte counts are shown here. On the X axis, the days after autologous transplant are shown.
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HHV-6 reactivation, known to have an incidence of 8-15% after ASCT, antiviral therapy with foscarnet was started, and subsequent shift to ganciclovir was realized, after hematological recovery. However, the constant increase of HHV-6 load, observed in conjunction of the augmentation of the leucocyte counts (see Figure 1), led to the alternative hypothesis of ciHHV-6, soon confirmed by the analysis of patient's follicle bulb at the beginning of October.