PMC3134051_01
Gingival enlargement in the right upper anterior region between the lateral incisor and the canine
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F1
It was firm, lobulated, and attached to the gingiva by a narrow stalk [Figure 1].
Intraoral, periapical radiograph of the region showing no bony involvement
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F2
The radiological examination of the region showed no bony involvement [Figure 2].
Micrograph at low magnification showing plasma cell infiltrate and elongated rete ridges
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F3
Hemotoxylin and Eosin stain, revealed a stratified squamous parakeratinized hyperplastic epithelium, with underlying fibrocellular connective tissue stroma [Figure 3], with fibroblasts, few lymphocytes, and abundant plasma cells [Figure 4]. However, a typical eccentrically placed hyperchromatic, cartwheel-shaped nucleus of the plasma cell was also evident [Figure 5].
Low power microscopy showing abundant plasma cells in the connective tissue
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F4
Hemotoxylin and Eosin stain, revealed a stratified squamous parakeratinized hyperplastic epithelium, with underlying fibrocellular connective tissue stroma [Figure 3], with fibroblasts, few lymphocytes, and abundant plasma cells [Figure 4]. However, a typical eccentrically placed hyperchromatic, cartwheel-shaped nucleus of the plasma cell was also evident [Figure 5].
High power microscopy showing plasma cells with eccentrically placed nucleus
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F5
Hemotoxylin and Eosin stain, revealed a stratified squamous parakeratinized hyperplastic epithelium, with underlying fibrocellular connective tissue stroma [Figure 3], with fibroblasts, few lymphocytes, and abundant plasma cells [Figure 4]. However, a typical eccentrically placed hyperchromatic, cartwheel-shaped nucleus of the plasma cell was also evident [Figure 5].
Immunohistochemistry for kappa chains
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F6
A strong positivity for the kappa light chain was seen in the polyclonal plasma cell population [Figure 6], whereas, a weak expression was noted for the lambda light chain [Figure 7], with a ratio of 2:1.
Immunohistochemistry for lambda chains
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F7
A strong positivity for the kappa light chain was seen in the polyclonal plasma cell population [Figure 6], whereas, a weak expression was noted for the lambda light chain [Figure 7], with a ratio of 2:1.