PMC4533432_01
Case 1. A preoperative magnetic resonance imaging (MRI) showing a medulla-T1 intramedullary mass with iso-/hypointensity on the sagittal T1-weighted image (A), mixed hyperintensity on the sagittal T2-weighted image (B), and heterogeneous enhancement on the sagittal (C) and axial (D) T1-weighted images with gadolinium. Case 2. A preoperative MRI showing a medulla-T4 ill-defined intramedullary mass with iso-/hypo-intensity on the sagittal T1-weighted image (E), hyperintensity on the sagittal T2-weighted image (F), and heterogeneous enhancement at the C3-C7 levels and linear enhancement on the surface of the cerebellum, brainstem, and spinal cord on the sagittal (G) and axial (H) T1-weighted images with gadolinium.
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F1
T4 spinal segments (Fig. 1E-H).
Photomicrographs of the surgical specimens in Case 1 (A-C) and Case 2 (D-F) illustrating sheets of uniform small round cells with finely speckled vesicular nuclei, clear perinuclear halos in areas of delicate fibrillary neuropils (A, D: hematoxylin-eosin stain, original magnification x100; B, E: hematoxylin-eosin stain, original magnification x200), and strong positivity for synaptophysin (C: original magnification x100; F: original magnification x200).
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F2
The diagnosis was confirmed by immunostaining (Fig. 2D-F).
Photomicrographs of the surgical specimens in Case 1 showing cytoplasmic positivity for synaptophysin (A) and nuclear positivity for NeuN (B) in the tumor cells (original magnification x400).
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F3
In particular, cytoplasmic positivity for Syn and nuclear positivity for NeuN was observed in the tumor cells (Fig. 3).
PMC4533432_02
Case 1. A preoperative magnetic resonance imaging (MRI) showing a medulla-T1 intramedullary mass with iso-/hypointensity on the sagittal T1-weighted image (A), mixed hyperintensity on the sagittal T2-weighted image (B), and heterogeneous enhancement on the sagittal (C) and axial (D) T1-weighted images with gadolinium. Case 2. A preoperative MRI showing a medulla-T4 ill-defined intramedullary mass with iso-/hypo-intensity on the sagittal T1-weighted image (E), hyperintensity on the sagittal T2-weighted image (F), and heterogeneous enhancement at the C3-C7 levels and linear enhancement on the surface of the cerebellum, brainstem, and spinal cord on the sagittal (G) and axial (H) T1-weighted images with gadolinium.
nmc-54-417-g1.jpg
PMC4533432_02_nmc-54-417-g1.jpg
F1
T4 spinal segments (Fig. 1E-H).
Photomicrographs of the surgical specimens in Case 1 (A-C) and Case 2 (D-F) illustrating sheets of uniform small round cells with finely speckled vesicular nuclei, clear perinuclear halos in areas of delicate fibrillary neuropils (A, D: hematoxylin-eosin stain, original magnification x100; B, E: hematoxylin-eosin stain, original magnification x200), and strong positivity for synaptophysin (C: original magnification x100; F: original magnification x200).
nmc-54-417-g2.jpg
PMC4533432_02_nmc-54-417-g2.jpg
F2
The diagnosis was confirmed by immunostaining (Fig. 2D-F).