PMC10016364_01
Tender mass of the right breast with mild nipple retraction.
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Voluminous painful tender mass (10x6 cm diameter) was located in upper inner of the right breast with retraction of the nipple (Figure 1).
Erythematous indurated nodules over the lower extremities.
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The dermatological examination revealed a typical erythema nodosum lesions characterized by multiple erythematous, painful, infiltrated nodules of varying size on the lower limbs (Figure 2).
(a) Non-caseating granulomatous infiltrate (hematoxylin and eosin staining). (b) Variety of inflammatory cells infiltrate (polymorph nucleated neutrophils, epithelioid histiocytes) with partial giant cell formation, no extracellular Mycobacterium tuberculosis was detected (Ziehl-Neelsen stain).
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Breast biopsies showed a lobulocentric subacute mastitis with a non-caseating granulomatous inflammation and multinucleated giant cells (Figure 3a and b).