PMC4382284_01
Map of Dielmo village.. The village is located at 13 45'N, 16 25'W and is composed of two hamlets showing the houses within the gametocyte hotspots (hotspot 1:blue, 1996-2003, Relative Risk (RR) 1.95, log likelihood ratio (LLR) 14.35 P = 0.0012; cluster 2:green, 1995-2002, RR 1.77, LLR 12.7 P = 0.0053) identified by SaTScan Also shown (large open red circle), area of the P. falciparum clinical episode hotspot identified by SaTScan; 1995-2003, RR 1.42, LLR 11.01 P = 0.026.
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A hotspot was observed with a radius of 82m from 1995-2003 (RR 1.42 Log likelihood ratio = 11.01, P = 0.026) that entirely overlapped the second gametocyte hotspot, encompassing 28 rooms and 73 people (Fig 1).
The proportion of P. falciparum positive bloodslides that are gametocyte positive.. This is according to time since last antimalarial drug treatment for each of the drug treatment regimens and separating the Chloroquine drug period into hotspot vs. non hotspot. Also shown are 95% binomial confidence intervals. Open: <= 30 days; Grey 30-60 days; Diagonal 61-90 days; Speckled 91-360 days.
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As can be seen in Fig 3, gametocyte positivity was higher within 30 days of treatment during the Chloroquine drug period as compared to later time points (Previous treatment within 30 days vs. treatment >30days ago: In hotspot chi2 1 = 26.2, P<0.001: outside hotspot chi2 1 = 74.2, P<0.001).