PMC8733465_01
Morphology and immunophenotype of high-grade B-cell lymphoma with MYC and BCL6 rearrangements at initial diagnosis. The H&E showed a large cell lymphoma with starry sky appearance. The lymphoma cells demonstrated distinct nucleoli and pale cytoplasm. Frequent mitoses were present. The lymphoma cells were positive for CD20, PAX5, MUM1 (subset), BCL6, MYC, and BCL2, and were negative for CD138. The Ki-67 proliferation rate was ~70%.
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A right inguinal lymph node biopsy showed a large cell lymphoma with starry sky appearance and frequent mitoses ( Figure 1 ).
Morphology and immunophenotype of high-grade plasmablastic neoplasm with MYC and BCL6 rearrangements at relapse. The H&E showed a large cell neoplasm with starry sky appearance and focal necrosis. The tumor cells demonstrated eccentric nuclei and pink cytoplasm. Frequent mitoses were present. The tumor cells were positive for EMA, MUM1 (diffuse strong), MYC, CD138, and Kappa, and were negative for CD20, PAX5, BCL6, and Lambda. The Ki-67 proliferation rate was ~90%.
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A core biopsy of one of the thigh masses showed a large cell neoplasm with starry sky appearance and multi-focal necrosis ( Figure 2 ).