PMC9815597_01
Blueberry muffin baby. (A) & (B) Disseminated dark red to purplish macules and papules on the face, neck, and upper limbs.
fped-10-1073624-g001.jpg
PMC9815597_01_fped-10-1073624-g001.jpg
F1
Physical examination revealed several scattered dark purple papules-like spots over the face, neck, and limbs of variable sizes (2-4 mm) (Figure 1).
Congenital cutaneous langerhans cell histiocytosis. (A). Dermal- hypodermal infiltration by histocytes (H & E. 20X), (B). The lesional cells have abundant, light eosinophilic cytoplasm and irregular nuclei with frequent nuclear folds and grooves (arrows), obscure nucleoli and fine chromatin.
fped-10-1073624-g002.jpg
PMC9815597_01_fped-10-1073624-g002.jpg
F2
The cells were positive for Langerin, CD1a, S100, and CD68 immunostains, consistent with cutaneous Langerhans cell histiocytosis (Figures 2,3).