PMC8717010_01
Right lobe of the thyroid, showing a small solid nodule, markedly hypoechoic, of 6/7.5/7mm, with a thin hypoechoic halo, "taller than wide" (ACR-TIRADS 5)
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The thyroid nodule was classified according to ACR-TIRADS classification, based on the nodule's ultrasound features, as TIRADS 5 (Figures 1a and 1b).
The same nodule in the right lobe of the thyroid, showing increased vascular flow on colour Doppler sonography
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The nodule had mild peripheral and no internal blood flow; it was classified as ACR-TIRADS 5 (Figure 2).
The left lobe of the thyroid with a large solid nodule, occupying the entire lobe, measuring 27.7/42.6/26.6 mm. The nodule has ill-defined margins, microcalcifications and no halo, mild peripheral and no internal blood flow
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It measured 51/45.7/40 mm (Figure 3).
Left laterocervical lymphadenopathy appearing as a round, hypoechoic, inhomogeneous mass, with mild internal vascularity and loss of hilar architecture
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In the left thyroid lobe, a high-grade tumor proliferation was identified, accompanied by large areas of tumor necrosis; the tumor infiltrated the thyroid capsule, with large extension into perithyroidal connective tissue and tumor cell emboli in the lymph and blood vessels from the thyroid and perithyroidal connective tissue (Figures 4 and 5).
Ultrasound (A) and pathological aspects (B, C) of anaplastic thyroid carcinoma in the left thyroid lobe, with hypercellularity, discohesive tumor cells, marked pleomorphism and multinucleated giant cells, (HE, x200)
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In the left thyroid lobe, a high-grade tumor proliferation was identified, accompanied by large areas of tumor necrosis; the tumor infiltrated the thyroid capsule, with large extension into perithyroidal connective tissue and tumor cell emboli in the lymph and blood vessels from the thyroid and perithyroidal connective tissue (Figures 4 and 5).