PMC4307882_01
(a) Brain MRI axial FLAIR and (b) T2-weighted sequence showing encephalomalacia in the anterior right frontal lobe and another discrete noncontiguous focus of encephalomalacia involving the posterior right frontal operculum.
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Right frontal biopsy showing focal cavitary gliosis sparing the molecular layer of the cortex (a) and ulegyria (b) in H&E staining; inflammatory cells CD-3/T-cells (c), CD-68/microglia (d), and CD-20/B-cells (e).
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Overall, the histopathology was suggestive of perinatal ischemia and a prominent inflammatory response (Fig. 3).