PMC3913423_01
Photomicrograph x4 H&E; spindle cell tumour with areas of haemorrhage and necrosis.
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A microscopic examination showed an atypical undifferentiated spindle cell lesion with a fascicular architecture, pleomorphism and marked mitotic activity with areas of ulceration and necrosis (Figs 1 and 2).
Photomicrograph x40 H&E; pleomorphic spindle cells in fascicles with several mitoses.
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A microscopic examination showed an atypical undifferentiated spindle cell lesion with a fascicular architecture, pleomorphism and marked mitotic activity with areas of ulceration and necrosis (Figs 1 and 2).
Photomicrograph showing negative cytokeratin AE1/AE3 staining in spindle cells.
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The initial set of immunostains performed showed that tumour cells were negative for cytokeratins (Fig. 3), S100 and LCA.
Photomicrograph showing vimentin-positive spindle cells.
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The tumour cells showed diffuse and strong vimentin positivity (Fig. 4).
Postoperative photograph demonstrating split thickness skin graft reconstruction.
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Reconstruction was with a split thickness skin graft by the plastic surgery team prior to her radiotherapy treatment (Fig. 5).