PMC9634458_01
Microscopic findings showed a highly cellular lesion that forms papillae with thick and thin fibrovascular axes, lined by one or more layers of polyhedral cells with slight pleomorphism, as well as rounded formations with a protein center and papillae (hematoxylin and eosin, x40).
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Extensive sampling in the peripheral areas revealed a tumor characterized by solid cell nests with richly vascularized fibrous stroma; sometimes a trabecular pattern with hyaline or myxoid stroma; a pattern that became pseudopapillary, with a small central vessel; and, finally, pseudo rosettes, where there was a loss of cohesion (Figure 1).
Nuclear immunoreaction against beta-catenin antibody, a diagnostic feature of solid and papillary neoplasms of the pancreas (immunohistochemistry, x100).
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The neoplasm was weakly positive for neuron-specific enolase (NSE) and showed strong nuclear positivity for beta-catenin (Figure 2).