PMC7803116_01
Photography of the anterior segment of the eye. (a) Numerous microcysts visible in the epithelial layer (red arrow) (mag. 16x). (b) Epithelial microcysts visible in retroillumination (red arrow) (mag. 10x).
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fig1
The other structures of the eye were normal (Figures 1(a) and 1(b)).
Comparison of representative SS OCT scans in the right and left eye. OD.SS OCT pachymetry map showing the increase of CCT to 611 mum. High-resolution SS OCT cornea scan showing numerous hyporeflective small and oval cysts (green arrow) as well as increased thickness of the central corneal epithelium to 154 mum. OS.SS OCT pachymetry map showing the CCT of 538 mum. High-resolution SS OCT cornea scan showing few oval shaped, hyperreflective material within the central corneal epithelium (red arrow). Central epithelium thickness is increased to 90 mum.
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fig2
Reflectivity of the corneal epithelium was normal and the increase of the central thickness was upto 90 mum which is significantly less severe compared to the right eye (Figure 2).
Confocal micrographs of the cornea. (a) IVCM micrograph of the superficial epithelium showing numerous small microcysts filled with highly reflective homogenous material (white arrow). Larger cysts filled with heterogenous hyporeflective and hyperreflective material (red arrows). (b) IVCM micrograph of the epithelium showing polymorphism along with disruption of a cytoarchitecture and disruption of the layered structure of the epithelium. Large cysts filled with heterogenous hyporeflective and hyperreflective material (red arrows). (c) IVCM image at the level of basal cells of corneal epithelium showing inflammatory changes. Brightly reflective and round structures visible at the centre of basal epithelial cells (red arrow). (d) IVCM micrograph of the Bowman layer showing increased density of Langerhans cells (white arrow) and activated keratocytes in the anterior stroma. Corneal nerve with normal morphology (red arrow). (e) IVCM image at the level of intermediate stroma showing activated keratocytes. (f) IVCM image of the endothelium with normal structure.
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fig3
Posterior corneal stroma and endothelium presented normal morphology (Figure 3).