PMC5883424_01
PMC5883424_02
PMC5883424_03
a Sagittal computed tomography angiography showing a left cerebellar hemisphere hemorrhage. b Thrombin generation curves obtained with 5pM tissue factor and 4 muM phospholipids (final concentration) in platelet-poor plasma using calibrated automated thrombin generation assay (Stago, Asnieres, France). The area under the thrombin generation curve (or endogenous thrombin potential) is significantly higher in the patient (red) compared to another subject with afibrinogenemia (blue) or a representative normal control (grey). In this patient with combined inherited antithrombin and fibrinogen deficiency, increased thrombin generation is due to insufficient inhibition of thrombin. Thrombin generation is decreased after infusion of 30 U/kg antithrombin concentrate (pink). c Visualization of the left coronary artery with computed tomography coronary angiogram showing 80% stenosis in the common trunk. d Visualization of the left coronary artery with computed tomography coronary angiogram showing 50% stenosis in the anterior interventricular branch of left coronary artery
12959_2018_162_Fig1_HTML.jpg
PMC5883424_04_12959_2018_162_Fig1_HTML.jpg
Fig1
The CT coronary angiogram revealed 80% stenosis in the common trunk of the left coronary artery and 50% stenosis in the anterior interventricular branch of the left coronary artery (Fig. 1c,d).
PMC5883424_04
a Sagittal computed tomography angiography showing a left cerebellar hemisphere hemorrhage. b Thrombin generation curves obtained with 5pM tissue factor and 4 muM phospholipids (final concentration) in platelet-poor plasma using calibrated automated thrombin generation assay (Stago, Asnieres, France). The area under the thrombin generation curve (or endogenous thrombin potential) is significantly higher in the patient (red) compared to another subject with afibrinogenemia (blue) or a representative normal control (grey). In this patient with combined inherited antithrombin and fibrinogen deficiency, increased thrombin generation is due to insufficient inhibition of thrombin. Thrombin generation is decreased after infusion of 30 U/kg antithrombin concentrate (pink). c Visualization of the left coronary artery with computed tomography coronary angiogram showing 80% stenosis in the common trunk. d Visualization of the left coronary artery with computed tomography coronary angiogram showing 50% stenosis in the anterior interventricular branch of left coronary artery
12959_2018_162_Fig1_HTML.jpg
PMC5883424_04_12959_2018_162_Fig1_HTML.jpg
Fig1
The CT coronary angiogram revealed 80% stenosis in the common trunk of the left coronary artery and 50% stenosis in the anterior interventricular branch of the left coronary artery (Fig. 1c,d).