PMC5118371_01
a, b MRI brain show a large, necrotic and calcified tumor (white arrow) in the parenchyma of the left frontal lobe with marked surrounding edema and mass effect on midline structures. The tumor appeared hypointense on non-contrast T1-weighted images and iso-to hyperintense on T2-weighted images. c-e The enhancement of the tumor was irregular and most prominent at its periphery. f Histopathology shows the tumor contained many neoplastic osteoid production (black arrow) and some calcifications (red arrow) (hematoxylin and eosin, original magnification, x200), and tumor cells strongly expressing Vimentin (g), P53 (h),osteopontin (i) and osteonectin (j). (immunohistochemistry, original magnification, x200, black arrow)
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Fig1
T2-weighted images (Fig. 1b). The enhancement of the tumor was irregular and most prominent at its periphery (Fig. 1c-e). The preoperative clinical diagnosis was meningioma or calcified glial tumor. She underwent incomplete resection of the tumor and histopathologic examination revealed a malignant mesenchymal neoplasm displaying a poorly differentiated spindle cells with interspersed eosinophilic osteoid production, calcification intimately associated with the malignant cells, and localized new bone formation (Fig. 1f). Immunohistochemistry was negative for epithelial membrane antigen (EMA), glial fibrillary acidic protein (GFAP), CD34, desmin and neurone specific enolase (NSE) but positive for vimentin (Fig. 1g), P53 (Fig. 1h), osteopontin (Fig. 1i) and osteonectin (Fig. 1j).