PMC5395275_01
Mammographic and sonographic appearance of the breast.. Notes: (A) Mammography of left breast, craniocaudal view, shows a nodule in the upper inner quadrant. (B) Ultrasound shows a defined hypoechoic nodule (arrow) with echogenic halo, difficult to differentiate from a malignant breast lesion.
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Ultrasonography confirmed it as a retroareolar solid nodule with a maximum diameter of 11.6 mm (Figure 1).
Breast biopsy under local anesthesia.. Notes: (A) Biopsy of the lesion in the left breast under local anesthesia. (B) Macroscopic view of the tumor. Scale bar=1 mm.
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A biopsy was carried out (Figure 2) and a histologic examination (Figure 3) of the biopsy suggested GCT, and deferred immunohistochemi-cal examination showed the typical receptors of this tumor (Table 1).
Histopathologic section of the granular cell tumor in the breast.. Notes: (A) Hematoxylin and eosin staining of granular cells in a lobular duct of the breast (arrow; 40x magnification). (B) Hematoxylin and eosin staining of the breast tissue showing large polygonal granular cells and cytoplasm and rounded nuclei (arrow; 200x magnification). (C) PAS-S100 staining displaying positive activity on the granular cells, highlighting cytoplasmic granularity (arrows; 200x magnification). (D) Calretinin staining showing positive activity on the granular cells (arrows) near to the hyperplasic epithelium (200x magnification).. Abbreviation: PAS, periodic acid-Schiff.
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A biopsy was carried out (Figure 2) and a histologic examination (Figure 3) of the biopsy suggested GCT, and deferred immunohistochemi-cal examination showed the typical receptors of this tumor (Table 1).