PMC9659588_01
Change of oral fungal infections (A) on day -7 before HSCT, (B) on day +30 after HSCT, and (C) on day +55 after HSCT.
fped-10-828918-g001.jpg
PMC9659588_01_fped-10-828918-g001.jpg
F1
Without effective infection control, the patient developed an oral fungal infection (Figure 1A) and pulmonary infections with MDR to bacteria and fungus due to long-term neutropenia and antibiotic use. Oral fungal infection was cured (Figure 1C).
Dynamic images of pneumonia before and after transplantation (A-C). Chest high-resolution computed tomography: (A) 3.3 x 2.7 cm nodular shadow in the right upper lung, with bilateral pleural effusion on day -7 before HSCT, (B) 3.3 x 3.1 cm nodular shadow in the right upper lung, with bilateral pleural effusion and left atelectasis on day +22 after HSCT, and (C) 2.3 x 2.0 cm nodular shadow in the right upper lung on day +59 after HSCT.
fped-10-828918-g002.jpg
PMC9659588_01_fped-10-828918-g002.jpg
F2
An aspergilloma and a large number of pleural effusions were found by CT scanning (Figure 2A). That might be because the patient suffered prolonged neutropenia before granulocyte engraftment (Figure 2B). Shrank aspergilloma was seen on day +59 (Figure 2C).
Change in inflammatory factor levels in CRP (A), PCT (B), IL-6 (C), and GM (D). The red dot in the line represents the beginning of preconditioning on Dec. 25, 2019, and the yellow dot represents the day of HSCT on Jan. 1, 2020. The patient received HSCT when inflammatory factors levels reduced markedly.
fped-10-828918-g003.jpg
PMC9659588_01_fped-10-828918-g003.jpg
F3
C-reactive protein (CRP) decreased from 175 to 68 mg/L, procalcitonin (PCT) from 3.5 to 0.1 ng/ml, and IL-6 from 1200 to 126 pg/ml (Figure 3). CT scan showed the bilateral pleural effusion was reduced significantly.