PMC9720430_01
Liver biopsy from a human with NAFLD and a rat model of NASH.. (A,B) Individual with NAFLD and (C) rat model. Courtesy of Salcedo M. and Barbera A, respectively. Representative images showing NASH features in absence of fibrosis, stained with (A) H&E and (B) picrosirius red. (C) Representative image showing liver parenchyma stained with H&E in the murine model after 36 weeks of dietary intervention. NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis.
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The NAFLD activity score was 7/8 (steatosis 3; lobular inflammation 2; ballooning 2) with fibrosis stage 1a (Fig. 1A-B).