PMC6232788_01
Chest radiography and CT images of patient 1.
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A 49-year-old, premenopausal, asymptomatic woman, with past clinical history significant for total hysterectomy 10 years earlier due to a leiomyoma of the uterus, presented with a miliary pattern in a routine chest radiography as in computed tomography (CT) scan (Figure 1).
PMC6232788_02
Chest radiography and CT images of patient 2.
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CT revealed multiple pulmonary bilateral nodules (Figure 2) with no FDG uptake in the PET scan. CT-guided biopsy of a pulmonary nodule was performed and the resected uterine leiomyoma was reviewed.
Histopathologic examination of BML and uterine leiomyoma of patient 2.
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Both specimens showed identical histopathology of a low grade, benign appearing, and smooth muscle tumor (Figure 3).
Immunohistochemical staining of BML and uterine leiomyoma of patient 2. (a) SMA, (b) Desmin, and (c) Hormonal Receptors.
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The immunohistochemical profile of BML is indistinguishable from that of the primary uterine tumor with positivity for SMA, desmin, estrogen, and progesterone receptors (Figure 4) and negativity for HMB-45, CD31, CD34, and EMA.
Cytogenetic study of BML and uterine leiomyoma of patient 2, using "Fluorescence In Situ Hybridization" (FISH), with probes LSI EWSR1 (22q12) Dual Color, Break Apart Rearrangement Probe, Abbott, and ZytoLight SPEC 19q13/19q13 Dual Color Probe, Zytovision. (a) 22q12 deletion and (b) 19q13 deletion.
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Cytogenetic analysis revealed shared profile between both samples, including 19q and 22q terminal deletions (Figure 5).