PMC4425312_01
At presentation, BCVA of a 52-year-old male patient with multiple myeloma was 20/50 in the right eye and 20/800 in the left eye.. Notes: (A and B) Color fundus image showed scattered flame-shaped hemorrhages, Roth spots, and serous macular detachment in both eyes. (C and D) FFA revealed scattered microaneurysms and hypofluorescent areas, but no macula leakage. (E and F) OCT revealed bilateral serous macular detachment, prominent middle limiting membrane (yellow arrow), and cysts in the outer plexiform layer of the left eye (white arrow).. Abbreviations: BCVA, best-corrected visual acuity; FFA, fundus fluorescein angiography; OCT, optical coherence tomography.
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Fundus examination in both eyes revealed scattered flame-shaped hemorrhages, Roth spots, venous dilatation and tortuosity, and serous macular detachment (Figure 1A and B). FFA revealed scattered microaneurysms and hypofluorescent areas but no macula leakage (Figure 1C and D). SD-OCT revealed a central macular thickness of 329 microm in the right eye and 705 microm in the left eye, the presence of serous macular detachment (Figure 1E and F), small cystic spaces within the outer plexiform layer, and prominent MLM (Figure 1F).
One month after presentation, BCVA was 20/32 in the right eye and 20/100 in the left eye.. Notes: (A and B) Color fundus image showed retinal hemorrhages, Roth spots, and yellow macular deposits. (C and D) Fluorescein angiography showed a reduction in microaneurysms. (E and F) SD-OCT showed a decrease in serous macular detachment in both eyes, and subretinal hyperreflective deposits. (G and H) Fundus autofluorescence showed hyperautofluorescent macular deposits.. Abbreviations: BCVA, best-corrected visual acuity; SD-OCT, spectral-domain optical coherence tomography.
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Fundus examination revealed a reduction in retinal hemorrhages and Roth spots and the presence of bilateral oval-to-round, yellow-to-orange deposits in the center of the macula (Figure 2A and B). FFA showed a decrease in microaneurysms and no macula leakage in both eyes (Figure 2C and D). SD-OCT revealed a central macula thickness of 299 microm in the right eye and 448 microm in the left eye, a decrease in serous macular detachment, and the presence of subretinal hyperreflective deposits in both eyes (Figure 2E and F). The yellow deposits observed in both eyes appeared hyperautofluorescent on fundus autofluorescence (Figure 2G and H).
Two months after presentation, BCVA was 20/20 in the right eye and 20/32 in the left eye.. Notes: (A and B) Color fundus image showed complete resolution of retinal hemorrhages and Roth spots and decrease in yellow macular deposits. (C and D) FA showed complete resolution of microaneurysms. (E and F) SD-OCT showed subretinal hyperreflective deposits and left serous macular detachment.. Abbreviations: BCVA, best-corrected visual acuity; FA, fundus autofluorescence; SD-OCT, spectral-domain optical coherence tomography.
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Fundus examination revealed a complete reduction in retinal hemorrhages and Roth spots, a decrease in yellow macular deposits (Figure 3A and B), and complete resolution of microaneu-rysms in both eyes (Figure 3C and D). SD-OCT revealed central macular thickness of 268 microm in the right eye and 340 microm in the left eye, minimal serous macular detachment in the left eye, a decrease in subretinal hyperreflective deposits, and the complete disappearance of cysts in the outer plexiform layer (Figure 3E and F).
Four months after presentation, BCVA was 20/20 in both eyes.. Notes: (A and B) Fundus examination revealed retinal hemorrhages had completely resolved. (C and D) FA revealed microaneurysms had completely resolved. (E and F) Fundus autofluorescence showed reduction in hyperautofluorescent macular deposits. (G and H) SD-OCT revealed complete resolution of serous macular detachment.. Abbreviations: BCVA, best-corrected visual acuity; FA, fundus autofluorescence; SD-OCT, spectral-domain optical coherence tomography.
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FFA revealed that microaneurysms (Figure 4C and D) had completely resolved. Fundus autofluorescence revealed that the appearance of hyperautofluorescent yellow deposits had decreased in the macula (Figure 4E and F).