PMC6077542_01
Contrast enhanced computed tomography (CE-CT) image showing cystic right ovary with arrow pointing to enhanced solid densities within the cyst.
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fig1
Contrast enhancement within the right ovarian cyst suggested the possibility of malignant transformation (Figure 1).
Blunt pale projections on an otherwise smooth cyst wall.
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Gross examination showed the right ovary to be cystic and measured 12cms in diameter and is predominantly smooth except for an area of 3cm2 which had blunt pale soft projections (Figure 2).
High power view of histomorphology of urothelial carcinoma (H&E 400X magnification).
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The microscopy of the soft pale projections of the right ovary had papillary structures with fibrovascular cores which were lined by transitional epithelium exhibiting nuclear pleomorphism, hyperchromatism, and increased mitotic activity (Figure 3).
Low power view of urothelial carcinoma with arrow pointing at nests of invasive malignant epithelial cells in ovarian stroma (H&E 10X magnification).
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There was evidence of invasion of the ovarian stroma by nests of malignant epithelial cells (Figure 4).
High power view of tumor cells showing cytoplasmic and membranous positivity for Uroplakin II (IHC 40X magnification).
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Immunohistochemistry (IHC) of the urothelial carcinoma showed cytoplasmic and membrane positivity for Uroplakin II (Figure 5).