PMC4809470_01
Large, confluent erosions in the perianal/perineal area and midgluteal fold.
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fig1
A 79-year-old white woman with a history of psoriasis and diabetes type 2 presented with recalcitrant, perianal/perineal, and perivaginal inflammatory erosions that were unresponsive to potent topical corticosteroids (Fig 1).
Generalized pruritic, urticarial and bullous lesions developed immediately after starting etanercept.
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Within 3 days of starting etanercept, the patient had generalized, pruritic, urticarial, and bullous lesions (Fig 2).
Biopsy section of a bullous lesion on the left upper thigh shows a subepidermal blister with prominent eosinophils. (Hematoxylin-eosin stain; original magnification, x200).
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Biopsy of a bullous lesion on the left upper thigh found a subepidermal blister with eosinophils (Fig 3).
DIF: linear C3 deposition at the dermal-epidermal junction. (Original magnification, x100).
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DIF of perilesional skin of both the right arm and perianal area found linear C3 and IgG at the dermal-epidermal junction (Fig 4).