PMC293480_01
Thoracic radiography showing the mass of the right lung.
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F1
Chest radiograph showed a round opacity in the right lung (Figure 1) and computed tomography revealed a well-demarcated mass lesion in the right upper lobe extending from the lateral chest wall to the hilum.
photomicrograph of the polypoidal mass of malignant melanoma showing endobronchial tumor with mucosal invasion. (Hematoxylin-Eosin x50).
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F2
Histologically the tumour was composed predominantly of epithelioid tumour cells, junctional change and mitotic activity with characteristic nesting of malignant cells beneath the bronchial epithelium was also seen suggesting a diagnosis of MM (Figure 2).
Photomicrograph showing malignant melanoma cells in alveolar pattern (Hematoxylin-Eosin x400).
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F3
The cells were arranged in alveolar pattern (figure 3).
Photomicrograph showing immunohistochemical staining of melanoma cells with antibody S-100 (Avidin-Biotin Complex x400).
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F4
The presence of MM was confirmed by positive immunohistochemichal reaction with antibodies to S-100 protein (Figure 4), and melanoma associated monoclonal antibody HMB45, whereas cytokeratin, CAM 5.2, and chromogranin were negative.