PMC6719276_01
Canine-photographs of progressive plaques over the right (a) and left (b) corneas.
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fig1
The right cornea was completely covered (Figure 1(a)) while only 1/3 of the left cornea was effaced (Figure 1(b)).
(a) Anterior cornea of the right eye (100X, H&E stain): surface epithelium is markedly hyperplastic with expansion of underlying stroma by small caliber vessels and multifocal pyogranulomatous nodules surrounded by infiltrates of lymphocytes and plasma cells. (b) Anterior cornea of the right eye (200X, H&E stain): higher magnification of previously described lesion highlighting pyogranulomatous inflammation.
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fig2
Histopathologic evaluation of both eyes revealed markedly expanded corneas due to pronounced hyperplasia of the surface epithelium, along with neovascularization, fibrosis of the stroma, and a marked infiltrate of numerous distinct pyogranulomas surrounded by a diffuse infiltrate of lymphocytes and plasma cells (Figure 2(a)). The pyogranulomas were characterized by a peripheral zone of epithelioid macrophages, fewer lymphocytes and plasma cells, and a central zone of polymorphonuclear cells (Figure 2(b)).