PMC9666900_01
(A) Doppler ultrasound:upper abdominal solid mass. (B) Gastroscopy: chronic atrophic gastritis C1: gastric antrum mass (to be examined).
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F1
Abdominal Doppler ultrasound showed a solid mass in the upper abdomen, which was suspected to be gastric cancer (Figure 1A). Gastroscopy revealed chronic atrophic gastritis stage C1 (C1: indicates atrophic gastritis involving the gastric sinus region) (Figure 1B).
Pathological examination of the specimen taken under gastroscopy revealed high-grade intraepithelial neoplasia in the (sinus) mucosal glands (arrow). (HEx100).
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F2
Pathological examination of the specimen taken under gastroscopy revealed high-grade intraepithelial neoplasia in the (sinus) mucosal glands (Figures 2A-D).
(A) The gastric antrum occupies space, the main lesion is located outside the gastric wall. (B) Patient's preoperative CT showed obvious lesions. (C) Postoperative CT of the patient showed significant resection of the lesion.
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F3
MRI of the abdomen showed that the gastric sinus was occupied, with the main lesion located outside the gastric wall (Figure 3A).
(A,B) Specimen: the size of the mass is about 9 cm x 7 cm x 6 cm, and the surface of the slice is red and gray, indicating solid, soft tissue. (C-F) Primary choriocarcinoma of the stomach, with Ovoid or polygonal, with hyaline, lightly stained or granular cytoplasm and a single vacuolated nucleus (HE x100).
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F4
The postoperative gross specimen showed a mass measuring approximately 9 cm x 7 cm x 6 cm, which was reddish-grey in section, suggestive of solid soft tissue (Figures 4A,B). The cells are of cytotrophoblastic and syncytial trophoblastic origin and are devoid of villous structures (Figures 4C-F).
Immunohistochemistry: CD10 (+) (A), ck8/18 (+) (B), CK19 (+) (C), CKP (+) (D) and Ki-67 labelling index of 60% (+) (E) (HE x200). Histochemical staining: PAS (+) (F) (SP x200).
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F5
Immunohistochemistry showed CD10 (+) (Figure 5A), ck8/18 (+) (Figure 5B), CK19 (+) (Figure 5C), CKP (+) (Figure 5D) and a Ki-67 labelling index of 60% (+) (Figure 5E). Histochemical staining showed PAS (+) (Figure 5F), while immunohistochemistry showed positive for HCG antibodies (Figure 6).
Immunohistochemistry: HCG(+) (SP x100).
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F6
Histochemical staining showed PAS (+) (Figure 5F), while immunohistochemistry showed positive for HCG antibodies (Figure 6).