PMC9830090_01
A solitary, cystic lesion with rim enhancement in the left frontal lobe in
T1-weighted axial (a) and sagittal (b) MRI.. MRI, magnetic resonance imaging.
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Three months after lung SBRT, routine MRI of the nasopharynx revealed a solitary, cystic brain lesion in the left frontal lobe; contrast-enhanced MRI confirmed the lesion (Figure 1a and b).
Pathological examination of the cystic wall (a) of the lesion. The cystic
fluid smear examination (b) shows the presence of tumor cells (hematoxylin
and eosin, original magnification x200). (c) Photomicrograph showing
positive Epstein-Barr virus-encoded RNA staining in tumor cells (in situ
hybridization, original magnification x200).
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The pathological findings were consistent with the results of the nasopharyngeal biopsy (Figure 2a and b). Epstein-Barr virus-encoded RNA (EBER) staining using in situ hybridization was positive in the brain lesion (Figure 2c), which further confirmed brain metastasis from NPC.
T1-weighted sagittal MRI images with contrast. (a) Multiple well-enhanced
sites along the needle tract; (b) Intracranial complete response after
combined therapy.. MRI, magnetic resonance imaging.
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The brain lesion and the multiple enhanced sites along the puncture needle tract demonstrated by MRI (Figure 3a) received 45 Gy radiotherapy in 15 fractions. Nearly 2 months after WBRT, brain lesion CR was achieved (Figure 3b).