PMC9533139_01
Multiple dull red plaques were observed on the lower limbs.
fped-10-972224-g001.jpg
PMC9533139_01_fped-10-972224-g001.jpg
F1
On physical examination, multiple dull red plaques were observed on the lower limbs (Figure 1) and splenomegaly with spleen 3 cm below the left costal margin was also noted.
Bone marrow studies revealed hypercellular marrow with granulocytic hyperplasia. (A) Bone marrow smear (Wright's stain; original magnification, x400). (B) Bone marrow biospy (Hematoxylin-eosin stain; original magnification, x100).
fped-10-972224-g002.jpg
PMC9533139_01_fped-10-972224-g002.jpg
F2
Bone marrow studies revealed hypercellular marrow with granulocytic hyperplasia (Figure 2), negativity for BCR/ABL and a + 8 karyotype.
Genomic analysis revealed a CSF3R T618I somatic mutation and a CBL c.1096-1_1097delGGA frameshift somatic mutation. (A) CSF3R T618I somatic mutation. (B) CBL c.1096-1_1097delGGA frameshift somatic mutation.
fped-10-972224-g003.jpg
PMC9533139_01_fped-10-972224-g003.jpg
F3
Genomic analysis revealed a CSF3R T618I somatic mutation and a CBL c.1096-1_1097delGGA frameshift somatic mutation (Figure 3).
Skin biopsy showed immature blasts infiltrate. (A) Hematoxylin-eosin stain; original magnification, x100. (B) Hematoxylin-eosin stain; original magnification, x400.
fped-10-972224-g004.jpg
PMC9533139_01_fped-10-972224-g004.jpg
F4
Skin biopsy revealed a few blasts infiltrated in the dermis without dermal edema (Figure 4).