PMC10338352_01
Renal histology. (A) Periodic acid-Schiff (PAS) stain shows mild to moderate mesangial matrix expansion and thick glomerular basement membranes. (B) Jones silver stain demonstrating basement membrane spikes. (C) Immunofluorescence staining reveals diffuse granular immunoglobulin G (IgG) capillary wall deposits and (D) C3 capillary deposits. (E) Electron micrograph images show numerous subepithelial electron dense deposits with expansion of glomerular basement membranes and (F) expansion of mesangial matrix with abundant mesangial deposits.
gr1.jpg
PMC10338352_01_gr1.jpg
fig0001
Light microscopy revealed thickened glomerular capillaries with pathognomonic pits and spikes on Jones methenamine silver stain (Fig. 1A and B). By electron microscopy, glomerular basement membranes (GBM) measured over 1000 nm (normal adult male average = 230-430 nm) with subepithelial immune complex-type electron-dense deposits and mesangial deposits (Fig. 1C and D).