PMC9716585_01
Colonoscopic image revealing the 1-cm polyp located in the ascending colon.
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Colonoscopy revealed an isolated 1-cm polyp in the ascending colon (Figure 1).
Hematoxylin and eosin (H&E) stain demonstrating gastrointestinal mucosa with the proliferation of Langerhans cells, characterized by abundant, pale eosinophilic cytoplasm, irregular and elongated nuclei with prominent nuclear grooves and folds, fine chromatin, and indistinct nucleoli with conspicuous eosinophils in the background (x20).
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Hematoxylin and eosin staining of the colon polyp (Figure 2) demonstrated gastrointestinal mucosa with proliferation of pale eosinophilic cytoplasm, irregular and elongated nuclei with prominent nuclear grooves and folds, fine chromatin and indistinct nucleoli, and conspicuous eosinophils in the background.
(A) Immunohistochemical (IHC) stain demonstrating scattered CD68 positivity of Langerhans cell histiocytosis (LCH) cells (x40); (B) IHC stain demonstrating strong positivity for S100 in the nuclei and cytoplasm of LCH cells (x40); (C) IHC stain demonstrating strong positivity of CD1a by LCH cells (x40).
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Immunohistochemical (IHC) staining revealed scattered positivity for CD68 (Figure 3A) and strong positivity for S100 (Figure 3B) and CD1a (Figure 3C).