PMC6012565_01
Infiltration of the cerebral cortex from a moderately differentiated adenocarcinoma (H&E x100).
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F1
Histology confirmed the presence of metastasis with morphology and immunophenotype consistent with gastrointestinal origin (figure 1).
Tested genes per site of neoplastic material or cell-free DNA that was subjected to next-generation sequencing. Muutated genes are depicted in dark.
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F2
Next Generation Sequencing of 50 cancer-related genes was thus applied in all resected neoplastic material available (figure 2).
Mutational evolution of the tumour in the various sites over time. CAPOX, capecitabine/oxaliplatin; FOLFIRI, folinic acid/5-fluorouracil/irinotecan; met, metastasis; res'd, resected; SCLN, subclavicular lymph node.
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F3
The clonal make-up of the malignancy over time is summarised in figure 3.