PMC4782401_01
FNAC material showed small cells with a narrow cytoplasm, oval-round nucleus, displaying a nuclear molding (A:MGG, x400). Residual ducts and glands are observed in the tumor. The tumor showed the features of SmCCs seen in other organs. (B:H and E, x400). Strong immunoreactivity with synaptophysin in tumor cells (C:Synaptophysin, x200)
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F1
Moderately pleomorphic small cells with a narrow cytoplasm, oval-round nucleus, displaying a nuclear molding, and having a salt-and-pepper chromatin pattern were observed in the May-Grunwald-Giemsa (MGG) stain [Figure 1a]. Mitotic rate was higher (>50 per 10 HPF) and there were necrotic areas in the neoplasm [Figure 1b]. Immunohistochemical staining provided a positive result with neuron-specific enolase (NSE), Synaptophysin, [Figure 1c] and Chromogranin A while epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), cytokeratin (CK) 7, CK20, thyroid transcription factor 1 (TTF-1), and S-100 protein were negative.