PMC4344963_01
Hematoxylin and eosin stained histologic section of the nodular lesion demonstrate diffuse infiltrate of anaplastic appearing cells with large nuclei, prominent nucleoli, and with moderate amounts of pink cytoplasm consistent with anaplastic large cell lymphoma (ALCL). Notice abundant background neutrophils.
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F1
Tissue and periprosthetic fluid removed from the wound site revealed an atypical lymphoid infiltrate (Figure 1).
High power view of hematoxylin and eosin-stained section highlights the anaplastic large lymphoma cells with large oval nuclei and prominent nucleoli
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F2
The histological section of the nodule showed anaplastic large cell lymphoma (ALCL) which was ALK-negative by immunohistochemical staining (Figures 2 and 3).
Immunohistochemical stain using CD30 antibody demonstrates uniform and strong expression of CD30 antigen in anaplastic large cells with membrane and Golgi patterns of staining.
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F3
The histological section of the nodule showed anaplastic large cell lymphoma (ALCL) which was ALK-negative by immunohistochemical staining (Figures 2 and 3).