PMC3588607_01
Computed tomography of the abdomen showing enlarged adrenal glands, the left gland measured 6.8 x 6.7 x 2.7 cm.
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Body computed tomography showed bilateral adrenal enlargement and a mass lesion at the base of the tongue (Figure 1).
Brain magnetic resonance imaging (flare) showing three lesions in the left frontal, temporal, and occipital lobes.
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Magnetic resonance imaging of the brain showed three left-sided brain lesions (Figure 2).
Adrenal needle biopsy section stained with hematoxylin and eosin showing necrotizing granuloma (original magnification, 10x).
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Biopsies of the tongue lesion and the left adrenal gland showed necrotizing granulomas containing budding yeast forms, consistent with histoplasmosis (Figures 3-5).
Adrenal needle biopsy section stained with hematoxylin and eosin showing granulomatous inflammation and a multinucleated giant cell containing small yeast surrounded by halos representing fungal capsules (original magnification, 20x).
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Biopsies of the tongue lesion and the left adrenal gland showed necrotizing granulomas containing budding yeast forms, consistent with histoplasmosis (Figures 3-5).
Adrenal needle biopsy section stained with Gomori methenamine silver showing small oval budding yeast typical of Histoplasma capsulatum (original magnification, 40x).
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Biopsies of the tongue lesion and the left adrenal gland showed necrotizing granulomas containing budding yeast forms, consistent with histoplasmosis (Figures 3-5).