PMC5350325_01
Photomicrograph of biopsy specimen of Case 1, showing the squamous cell carcinoma component (middle) and the adenoid cystic carcinoma component (upper left) (Hematoxylin and Eosin x100).
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fig1
Histopathological examination of the sampled material showed multiple fragments, some of which were composed of a squamous mucosa with a squamous carcinoma in situ (Figure 1).
Photomicrograph of biopsy specimen of Case 1, showing the adenoid cystic carcinoma component, cribriform pattern (HE x400).
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fig2
Tumor cells were small, basaloid with hyperchromatic nuclei and scant cytoplasm (Figure 2).
Immunostaining with CD 117: the adenoid cystic carcinoma cells are positive.
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fig3
On immunohistochemical study, ACC tumor cells showed positive staining with CD117 (Figure 3).
Immunostaining with P63: squamous cell component is positive (right), while adenoid cystic component is negative (left).
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fig4
P63 was negative in the adenoid cystic component and diffusely positive in the squamous cell carcinoma in situ (Figure 4).
PMC5350325_02