PMC3992752_01
HMRS study of brain. (a) T2 sequence showed hyperintensities in both basal ganglia. (b, c) Showed concentrations of glutamate by multivoxel imaging (TR 4200 TE 103.8). The inner green square identified a single voxel. (d) Magnetic resonance spectroscopy curve showed elevated glutamate levels (arrowhead)
AIAN-17-123-g001.jpg
PMC3992752_01_AIAN-17-123-g001.jpg
F1
T2 sequences showed mild hyperintensities in basal ganglia bilaterally [Figure 1a]. Simultaneously, magnetic resonance spectroscopy was carried out with single [inner green box in Figure 1b] and multi-voxel regions [outer white box in Figure 1b] of interest. Figure 1c shows a similar image at a different level. Figure 1d shows the presence of increased levels of glutamate in the single-voxel ROI (625 mm2) (arrowhead) with relaxation time (TR) 4200 and excitation time TE 103.8. A heat map of the glutamate concentration was generated [Figure 1b and c], which showed increased levels of glutamate in both the basal ganglia.
Radon transformation of the glutamate concentrations in the multi-voxel regions of interest in Figure 1. This revealed a bilaterally symmetric involvement of basal ganglia
AIAN-17-123-g002.jpg
PMC3992752_01_AIAN-17-123-g002.jpg
F2
The result showed marked symmetry [Figure 2], confirming equal participation of both hemispheres.