PMC4300286_01
beta-hydroxybutyrate (betaHB) concentrations rose to 3-7mM one hour after ingestion of ketone monoester (KME) in three different doses, 25g, 35g, and 50g, taken on separate days. The peak levels measured are in the range of those obtained during adherence to the classical ketogenic diet, and are about tenfold the concentrations achievable by medium-chain triglyceride (MCTG) administration. Because no more than two betaHB measurements were made during the first 2 hours after KME ingestion, higher levels might have been reached that were not detected. The findings suggest that substantially elevated blood ketone concentrations can be maintained throughout the day if KME is taken every 3-4 hours. Precision Xtra Glucose and Ketone Monitoring System  (Abbott) was used to measure betaHB levels in capillary blood samples. Acetoacetate (AcAc), ordinarily a minor fraction of total blood ketones, was not measured.
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F2
Plasma betaHB levels were measured occasionally to assess KME-plasma betaHB dose-response relationships (Fig. 2).