PMC9713006_01
Diffuse erythema with severe ulceration and necrosis on the patient's arms, hands, legs, and feet.
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F1
In April 2021, cutaneous lesions manifested as diffuse erythema with ulcers, obvious pain, and tenderness appeared over the limbs (Figure 1), but without swelling, fever, or joint pain.
Histopathological findings of the cutaneous lesions on the left leg. Hyperkeratosis, acanthosis, and obvious angioectasia in the dermal papilla and mild lymphocytic infiltration around the dermal vessels (hematoxylin-eosin, original magnification 10x).
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F2
There was obvious angioectasia in the dermal papilla and mild lymphocytic infiltrate around the dermal vessels (Figure 2).
Evident regression of the cutaneous lesions of the patient's arms, hands, legs, and feet after the antiplatelet therapy.
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F3
After the treatment with aspirin for 2 months, her cutaneous ulcer healed and the diffuse erythema disappeared, with only atrophie blanche and skin hyperpigmentation left (Figure 3).