PMC3496968_01
Abnormal SurePath Pap test cells interpreted as "atypical squamous cells, cannot rule out a high-grade squamous intraepithelial lesion" (original magnification 400x); residual SurePath vial fluid tested negative using the Hybrid Capture 2 test for high-risk human papillomavirus.. Note: Forty-two months later the patient was diagnosed with stage 1B1 cervical squamous cell carcinoma.
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Forty-two months before her diagnosis of cervical cancer, the patient had a SurePath Pap test interpreted as "atypical squamous cells, cannot rule out a high grade squamous intraepithelial lesion" (Figure 1).
Abnormal SurePath Pap test cells interpreted as "high-grade squamous intraepithelial lesion" (original magnification 400x); residual SurePath vial fluid tested negative using the Hybrid Capture 2 test for high risk human papillomavirus.. Note: One month later the patient was diagnosed with stage 1B1 cervical squamous cell carcinoma.
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A third SurePath Pap test was obtained and reported as "high-grade squamous intraepithelial lesion" (Figure 2).
PMC3496968_02
Invasive poorly differentiated cervical squamous carcinoma (original magnification 200x); diagnosed after two negative Hybrid Capture 2 human papillomavirus tests from SurePath vial fluid.. Note: Human papillomavirus 16 DNA was detected in tumor tissue by polymerase chain reaction.
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Final pathologic diagnosis was of a cervical SCC (1.5 cm maximum tumor dimension) invading the upper third of the cervix with no lymphovascular invasion identified, and negative lymph nodes - stage 1B1 (Figure 3).
PMC3496968_03