PMC9167837_01
Nodular sclerosis classic Hodgkin lymphoma. (A) Nodular growth pattern surrounded by fibrous collagen bands (H&E, 40x). (B) Lacunar cells were present with inflammatory cells as background (H&E, 400x). (C) CD 30 positive (IHC, 400x). (D) CD 15 positive (IHC, 400x).
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The cervical lymph node biopsy specimen (Hematoxylin & Eosin staining (H&E)) showed lymph nodes with nodular growth pattern surrounded by collagen bands (Figure 1A). There were Hodgkin Reed-Sternberg cells, lacunar cells, small lymphocytes, and other inflammatory cells as background (Figure 1B). The immunohistochemistry (IHC) showed positive for CD 30 (Figure 1C), CD 15 (Figure 1D), and MUM1, dim positive for PAX.
(A) PET scan before chemotherapy showed prominent involvement of right inferior jugular, right posterior cervical, right supraclavicular, and right superior paratracheal lymph nodes; para-arcus aorta, aortopulmonary window, upper lobe of left lung, peritoneum, and mesenterial lymph nodes with diffuse metabolic activity of all bone marrow, (B) PET scan after 8 cycles of BV showed complete remission of the tumor.
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The PET scan before and after eight cycles of BV are shown in Figures 2A and B, respectively. The evaluation of the PET scan after the end of cycle-8 showed complete remission (Figure 2B).