PMC10064287_01
PET/CT imaging at baseline (a), 3 months (b), and 6 months (c) following initiation of treatment with sotorasib from left to right.
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F1
Restaging PET/CT about 3 months after SBRT (Fig. 1a) showed an FDG-avid mediastinal, level 8 lymph node (SUV max = 9.3), scattered new FDG-avid lymph nodes in the right cardio phrenic angle up to 1.6 cm (SUV max = 12), and new right-sided pleural nodules up to 1.9 cm (SUV max = 13). After 3 months of treatment, PET/CT imaging was performed to evaluate treatment response (Fig. 1b). The patient had a complete response as per RECIST (response evaluation criteria in solid tumors) with complete resolution of all sites of FDG-avid disease, and the response was stable on a subsequent PET/CT scan 6 months (Fig. 1c) after initiation of sotorasib.