PMC5851332_01
Timeframe regarding diagnosis and treatment of patient 1. The figure presents the main treatment features and therapeutic approaches in patient 1.
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fig1
The patient was a 40-year-old Asian female diagnosed with AML during pregnancy (Figure 1).
Stained biopsy from patient 1. (a) Histologic image (hematoxylin/eosin staining) of the breast biopsy showing a diffuse infiltrate of tumor cells with scant cytoplasm and large nuclei with "open" chromatin pattern and distinct nucleoli, consistent with blasts. The blasts infiltrate around small residual acini (black arrows) in a lobule (white arrow). (b) The tumor cells are myeloperoxidase positive by immunohistochemistry. (c) Dim to moderate positivity by immunohistochemical staining for CD56. Size bars: 80 microm.
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fig2
She presented with a tumor in her left breast 62 months after the allo-SCT, and biopsy confirmed the diagnosis of myeloid sarcoma (Figure 2).
PMC5851332_02
Timeframe regarding diagnostic and treatment of patient 2. The figure presents the main treatment features and therapeutic approaches in patient 2.
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fig3
This patient was a 34-year-old Caucasian male diagnosed with normal karyotype AML (46, XY) without mutations in the FLT3 or NPM1 genes (Figure 3).
Stained biopsy from patient 2. (a) Subepithelial diffuse infiltrate of blasts in the biopsy specimen from the epipharyngeal lesion (hematoxylin/eosin staining). Black arrow: respiratory epithelium. (b) Virtually all the blasts are myeloperoxidase positive by immunohistochemistry. (c) The tumor cells are negative for CD56. Size bars: 80 microm.
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fig4
Thirty-nine months after allo-SCT, he presented with symptoms from his left ear, and he was diagnosed with an epipharyngeal tumor; biopsies from this lesion demonstrated tumor of myeloid origin (Figure 4).