PMC8121582_01
Histopathological evaluation of pulmonary biopsy. (a) HE (x40). (b) PAS (x100). Stained pulmonary biopsy reveals "Hodgkin cells." Immunofluorescence staining of these Hodgkin cells is negative for kappa (c) and lambda (d).
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Pathological findings of CT-guided biopsy of the tumor confirmed stage IIB nodular sclerosis classical HL (Figure 1).
Histopathological evaluation of renal biopsy. (a) PAS (x40). (b) PAS (x100). Stained renal biopsy sections at diagnosis reveal mesangial proliferation and subendothelial deposits (arrowheads). Immunofluorescence staining of these deposits is positive for IgG (c) (x40) and C3 (d) (x40). Immunostaining of the light chain is positive for kappa light chain (e) (x40), negative for lambda light chain (f) (x40), and positive for IgG3 (g) (x40). Using electric microscopy ((h) (x2,500), (i) (x25,000)), these deposits are composed of a tubular structure with a diameter of 50 nm. Black bars in (h) and (i) represent 2.5 mum and 500 nm, respectively.
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fig2
PAS-positive and Congo red-negative deposits were observed in the glomerular capillary walls (Figures 2(a) and 2(b)). IgG and C3 in the deposits (Figures 2(c) and 2(d)). Immunohistochemistry showed positivity for kappa light chain (Figure 2(e)) and IgG3 (Figure 2(g)) and negative for lambda light chain (Figure 2(f)), IgG1, IgG2, IgG4, and C1q (data not shown). Electron microscopy indicated randomly aligned tubular structures located in the subendothelial and mesangial areas of the glomeruli (Figures 2(h) and 2(i)).