PMC9807349_01
(a) CT at the first visit. A 43-mm-sized mass was detected on the left posterior wall of the bladder, accompanied by a twitch in the wall, and an 8-mm-sized low-concentration nodule in size in the S6 region of the liver. (b) CT after irinotecan and carboplatin treatment. The bladder tumor shrank significantly, with only a mild thickening of the bladder wall. The liver tumor was obscured.
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CT and MRI revealed a 43-mm-sized muscular invasive tumor on the left side of the bladder wall, left-side hydronephrosis, and 10-mm-sized liver metastasis (Fig. 1a). IrC therapy, a repeat CT scan showed shrinkage of the bladder tumor and liver metastasis (Fig. 1b). IrC therapy was discontinued due to the occurrence of bone marrow suppression after 16 cycles (Fig. 3).
The pathological tissue sampled by transurethral resection. Microscopic images of hematoxylin and eosin staining of the specimens are presented in the panels, and 40x and 200x fields of view. Poorly differentiated tumors consisting of solid proliferations of round- to spindle-shaped cells were observed. The nuclear chromatin in the cytoplasm of each tumor cell appeared fine and poor. The adjacent cells often contact each other, similar to a mold. Urothelial carcinomas were not observed.
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Transurethral resection of the bladder tumor was performed, and the patient was pathologically diagnosed with SCCB with muscular layer infiltration (Fig. 2).
Treatment course and changes in tumor markers. The NSE levels returned to normal after one course of IrC therapy. Even after the completion of treatment, the NSE levels did not increase.
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IrC therapy, a repeat CT scan showed shrinkage of the bladder tumor and liver metastasis (Fig. 1b). IrC therapy was discontinued due to the occurrence of bone marrow suppression after 16 cycles (Fig. 3).