PMC8419498_01
Preoperative view: small lesion with regular round border on the middle lower lip and a large, budding, crusty, and hemorrhagic lesion on the left side of the lower lip.
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fig1
The extra oral examination revealed the presence of two concomitant lesions on the lower lip; the first one was small (10 mm) with a regular round border and tender on palpation, the second one was rather budding, large (approximately 40 mm), crusty, and hemorrhagic (Figure 1).
Histological sections: infiltrating carcinomatous proliferation showing squamous differentiation of the labial mucosa (a) small lesion, H&E: 40; (b) large lesion, H&E: 100x.
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fig2
The incisional biopsy of the two lesions, performed under local anesthesia, concluded to well-differentiated squamous cell carcinomas after histological exams (Figure 2).