PMC6051126_01
Left breast basal cell carcinoma showing ulcerations and bleeding.
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Examination of the left breast revealed a large fungating mass of >10 cm in size, occupying most of the mid and outer breast with a distortion of the nipple areolar complex (Figure 1).
Histological findings on excisional biopsy H&E (hematoxylin and eosin stain) 2x, demonstrate nests of tumor cells arising from the surface epidermis.
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The initial histopathological exam was suggestive of an epidermal origin of the cancerous cells, raising the possibility of an adnexal primary such as basal cell carcinoma (Figures 2 and 3).
Histological findings on excisional biopsy H&E (hematoxylin and eosin stain) 10x show peripheral palisading of the tumor cells at the periphery of the nests.
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The initial histopathological exam was suggestive of an epidermal origin of the cancerous cells, raising the possibility of an adnexal primary such as basal cell carcinoma (Figures 2 and 3).
Immunohistochemical (IHC) stain 20x shows tumor cells to be negative for GATA3 (note: positive in breast primary).
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Immunohistochemical (IHC) profile also favored a primary skin disorder over a breast primary (Figures 4 and 5).
IHC stain (SMA:smooth muscle actin) 20x shows the normal epidermis to be negative (which is what is expected), but the tumor cells show strong cytoplasmic positivity. The circles that are also staining is smooth muscle in normal blood vessels (positive internal control).
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Immunohistochemical (IHC) profile also favored a primary skin disorder over a breast primary (Figures 4 and 5).