PMC4651860_01
Cortical thickness map showing regional distribution of atrophy in the patient with PPA. The pial surfaces of each hemisphere are rendered above, and inflated views revealing areas in sulci and the perisylvian fissure are shown below. Areas where the cortex is significantly thinner than in controls are shown in red-yellow, thresholded to a false discovery rate of 0.05. Atrophy was confined to the left temporal lobe and insula. 18F-FDG PET testing (not shown) showed hypometabolism in additional areas including frontal and temporoparietal components of the language network, and in ATL in the right hemisphere.
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F1
The patient showed significantly thinner cortex in the left temporal lobe and insula (Figure 1), with peak atrophy on the anterior section of the temporal lobe (ATL) extending posteriorly along the middle-temporal gyrus.