PMC9869346_01
Clinical time-course changes in the present case. Cardiac output was measured by using the indirect Fick method. 6MWD, 6-min walk distance; BNP, brain natriuretic peptide; BP, blood pressure; CI, cardiac index; dPAP, diastolic pulmonary artery pressure; DPG, diastolic pressure gradient; HR, heart rate; mPAP, mean pulmonary artery pressure; PAPi, pulmonary artery pulsatility index; PAWP, pulmonary arterial wedge pressure; PVR, pulmonary vascular resistance; RAP, right atrial pressure; REVEAL, Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management; RVSWi, right ventricular stroke work index; sPAP, systolic pulmonary artery pressure; WHO-FC, World Health Organization functional class.
gr1.jpg
PMC9869346_01_gr1.jpg
fig1
Fig. 1). Follow-up right heart catheterization, after achieving euvolemia by using diuretics, on the 25th day showed a sustained increase in the mPAP (35 mm Hg) and PVR (14.7 Wood units), despite a decrease in the PAWP (6 mm Hg), revealing a shift from combined pre- and post-capillary PH to pre-capillary PH (Table 1; Fig. 1; Supplemental Combination therapy with PH-targeted drugs and ruxolitinib finally improved the REVEAL 2.0 score (6 points) without worsening left-sided HF on the 263rd day (Fig. 1).