PMC3425501_01
T1-weighted MRI scans of R's lesion.. (a) Sagittal images highlighting damage to the insular cortex, (b) sagittal images highlighting damage to the ACC, and (c) coronal images highlighting damage to the mPFC. All three structures are extensively damaged, bilaterally, in R's brain.
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PMC3425501_01_pone.0038413.g001.jpg
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His brain damage is bilateral, more extensive on the right, and encompasses the target regions of the hypotheses under scrutiny: the insular cortex, the ACC, and the mPFC (Figures 1, 2).
Structural imaging.. Series of axial slices organized in a ventral-to-dorsal direction (ventral-most = top left; dorsal-most = bottom right). Slices are grouped in series of three, corresponding respectively to T2-weighted, T1-weighted and FLAIR imaging sequences of the same slice in the brain. The ventral-most set is in the top-left; next is the top-right; next is the second row-left, next is the second row-right, etc. Slices are sampled every 4 mm. Slices are in neurological convention (left side of image = left hemisphere; right side of image = right hemisphere). Dashed white arrows point to areas of abnormality detected on the FLAIR scan within the region of the left anterior insula. Continuous white arrows point to the mPFC/ACC region, highlighting the extensive bilateral destruction of these regions.
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PMC3425501_01_pone.0038413.g002.jpg
pone-0038413-g002
His brain damage is bilateral, more extensive on the right, and encompasses the target regions of the hypotheses under scrutiny: the insular cortex, the ACC, and the mPFC (Figures 1, 2).