PMC9976949_01
Colonoscopy image (case 1) - note: whitish patches on colonic mucosa
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FIG1
He had a colonoscopy done, which showed whitish, patchy lesions on the mucosae of the caecum and transverse colon suspected to be candidiasis, and biopsies were taken (Figure 1).
Photomicrograph case 1, H&E x20 - note: pigment-laden macrophages in lamina propria
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FIG2
No atypical cells were seen (Figure 2).
Photomicrograph case 1, PAS x20 - note: uniform purple particles in the lamina propria macrophages. PAS: periodic acid-Schiff
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FIG3
Photomicrograph case 1, PAS x100 (zoom) - note: uniform purple particles in the lamina propria. PAS: periodic acid-Schiff
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FIG4
PMC9976949_02
Colonoscopy image (case 2) - note: whitish patches on colonic mucosa
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FIG5
The colonoscopy showed the mucosa of the cecum appearing granular with punctuate whitish deposits (Figure 5).
Photomicrograph case 2, H&E x20 - note: pigment laden macrophages in the lamina propria
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FIG6
No atypical cells were seen (Figure 6).
Photomicrograph Case 2, PAS x20 - Note uniform purple particles in the lamina propria macrophages. PAS: periodic acid-Schiff
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FIG7
For confirmation, PAS histochemical and human melanoma black 45 (HMB45) immunohistochemical stains were applied to sections from the paraffin wax blocks of the specimen, which stained positive and negative, respectively (Figures 7, 8).
Photomicrograph case 2, PAS x100 (zoom) - note: uniform purple particles in the lamina propria macrophages. PAS: periodic acid-Schiff
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FIG8
For confirmation, PAS histochemical and human melanoma black 45 (HMB45) immunohistochemical stains were applied to sections from the paraffin wax blocks of the specimen, which stained positive and negative, respectively (Figures 7, 8).