PMC6877988_01
Desquamative changes in relation to the 43, 44, 45, and 46 regions.
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The intraoral examination revealed desquamative changes in relation to the 43, 44, 45, and 46 regions (Figure 1).
Ulceroproliferative lesion extending from the 44 to 47 regions.
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An ulceroproliferative lesion extending from the 44 to 47 regions with mixed keratotic and erythematous area with granular appearance was noted (Figure 2).
Desquamative lesion noted in relation to 13 extending to the 15 regions.
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Desquamative lesion was noted in relation to 13 extending to 15 regions (Figure 3).
Generalized horizontal bone loss with severe bone loss in relation to the 45 and 46 regions with widening of the PDL space and furcation involvement in relation to 46. Impacted 18 and 28.
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Impacted 18 and 28 were noted (Figure 4).
Diffused poorly defined radiolucency was noted in relation to 45 and 46 extending up to the superior border of the mandibular canal.
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Diffused poorly defined radiolucency was noted in relation to 45 and 46 extending up to the superior border of the mandibular canal (Figure 5).
(a, b) Incisional biopsy.
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Incisional biopsy of the oral lesion extending from the marginal gingiva of 44 to 46 to the mucogingival junction (measuring about 1.4*1.3*0.6 cm in size) was performed under LA (Figure 6).
(a, b) Excised tissue and surgical site after excision.
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The excised tissue was sent for histopathological examination (Figure 7). 3-0 vicryl sutures placed and a surgical pack given (Figure 8).
Surgical pack.
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The excised tissue was sent for histopathological examination (Figure 7). 3-0 vicryl sutures placed and a surgical pack given (Figure 8).
(a) 4x and (b) 10x: histopathologic view of the lesion showing islands and sheets of malignant squamous epithelial cells infiltrating into the connective tissue. Areas showing severely atrophic epithelium with few saw toothed rete pegs and basal cell degeneration are also seen. (c1, c2) 40x: higher magnification showing neoplastic cells with numerous keratin pearl formations, nuclear and cellular pleomorphisms, and mitotic figures. Few dilated blood vessels were also noted.
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Histopathological examination of the given soft tissue section revealed islands and sheets of malignant squamous epithelial cells infiltrating into the connective tissue (Figures 9(a) and 9(b)). The neoplastic cells exhibit numerous keratin pearl formation, nuclear and cellular pleomorphism, and mitotic figures (Figure 9(c) (c1, c2) 40x).