PMC10413550_01
Preoperative coronal MRI of precontrast T2WI (A), precontrast T1WI (B), and enhanced T1WI (C). Postoperative coronal MRI of precontrast T2WI (D) and precontrast T1WI (E).
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Subsequent enhanced MRI of the brain depicted a homogeneously enhancing pituitary mass extending into the bilateral sphenoid sinus and invading the clivus, measuring approximately 3.1x3.4x2.7 cm in size ( Figures 1A-C ). Postoperative MRI of the brain showed a shrinkage of the lesion ( Figures 1D, E ).
Histological surgical specimens. HE staining of the intrasellar mass (A) showed polymorphic cytological structure with a high nuclear-to-cytoplasmic ratio and an acinar to glandular growth pattern. HE staining of the dura mater (B) showed that the collagen fibers were irregular and widely invaded by tumor cells. HE staining of the saddle floor bone (C) showed that normal trabecular and cell patterns were largely interrupted by tumor cells. Immunohistochemical staining of Arg-1 (D), CAM5 (E), CD10 (F), GPC-3 (G), hepatocyte (H), and Ki-67 (I) confirmed the diagnosis of metastatic HCC.
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The intraoperative frozen section indicated metastatic HCC, which was further confirmed in postoperative immunohistochemical reports ( Figure 2 ).