PMC6374989_01
A: Interstitial fibrosis and tubular atrophy and glomeruli showing sclerosis associated with fibrous crescents (PAS, x 200). B: Cellular crescent obliterating glomerular capillaries (H&E, x 200). C: Cellular crescent replacing glomerular tuft. A few residual capillaries are evident (PAS, x 400).
CNCS-7-001-01.jpg
PMC6374989_01_CNCS-7-001-01.jpg
Figure1
A renal biopsy showed severe glomerular injury characterized by crescentic glomerulonephritis (Figure 1).
A: Smudgy linear staining for IgG along glomerular capillary walls (x 400). B: Fragments of glomerular capillary wall with linear staining for IgG (x 630). C: Glomerular tuft compressed by fibrous crescent and showing smudgy linear staining for C3 (x 630).
CNCS-7-001-02.jpg
PMC6374989_01_CNCS-7-001-02.jpg
Figure2
Deeper tissue level immunofluorescence revealed both smudgy and linear staining for IgG, kappa-light chain, and lambda-light chain in glomerular capillary walls compressed by crescents (Figure 2).