PMC9204269_01
Clinical course of the 48-year-old patient. Timeline showed the dynamic monitoring of the patient's body temperature, and the level of CRP, ALT, AST, GGT. Besides, daily treatment schemes of the patient were recorded. CRP, C-reactive protein; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, gamma-glutamyltransferase; LEV, levofloxacin; TZP, piperacillin-tazobactam; ACV, acyclovir; DOX, doxycycline; DXM, dexamethasone; ivgtt, intravenously guttae.
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F1
It found that the level of CRP reached 107.8 mg/L (normal range 0-8 mg/L) (Figure 1).
The mapped reads of C. burnetii, with the genome coverage of 0.024%. It showed the distribution of ten "Unique mapping" reads of C. burnetii identified by mNGS in the overall genome of C. burnetii. The ten reads covered 0.024% of C. burnetii genome. "Mutiple Mapping" indicates that the read can be mapped with the genome of C. burnetii, but not unique. "Unique Mapping" means that the read can be uniquely mapped to the genome of C. burnetii, but cannot be mapped to other species. Each read of "Unique Mapping" has its corresponding "Identity". One purple line that represents "Identity" is at around 1.7 M genomic position. Another nine of the ten "Identity" curves are 100% overlapping with the green "Unique Mapping" curves, thus, they are not visible in this figure.
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F2
The total number of bases in the genome of C. burnetii was 2,094,377 bp, and the total sequence length of C. burnetii measured in this study was 500 bp, covering 0.024% of the C. burnetii genome (Figure 2).