PMC6448118_01
Abdominal CT shows a well-enhanced 25-mm retroperitoneal tumor that is located between the aorta and IVC (arrow): (a) axial CT image, (b) coronal CT image. MRI shows that the tumor is a high signal intensity on (c) T2-weighted image, (d) a well enhanced on T1-weighted image, (e) high signal intensity on diffusion-weighted image, and (f) low signal intensity on ADC-map.
10.1177_2050313X19839532-fig1.jpg
PMC6448118_01_10.1177_2050313X19839532-fig1.jpg
fig1-2050313X19839532
Computed tomography (CT) scan showed a contrast well-enhanced retroperitoneal tumor of 25 mm in diameter that located between the aorta and IVC (Figure 1(a) and (b)). On magnetic resonance imaging (MRI), the mass had a high signal intensity on T2-weighted images and diffusion-weighted images, and contrast-enhanced homogeneously (Figure 1(c)-(f)).
Pathological findings. Histopathologic findings show lymph follicles with expanding mantle zone. Intra-follicular stroma shows a marked proliferation of hyalinized vessels. The vessels penetrate germinal center to form a "lollipop" follicle, and follicular dendritic cells and small lymphocytes form concentric rings ("onion skin" appearance). These findings are consistent with those of hyaline vascular type Castleman's disease. (a) Lymph follicles (F and white circle) with expanding mantle zone (MZ) and inter-follicular vascular proliferation with hyalinous thicken wall (VW). (b) Atrophic follicular germinal centers (GC) within a mantle zone. (c) Hyalinized vessel penetrating germinal center ("lollipop" appearance). (d) Follicular dendritic cell and small lymphocytes palisaded around germinal center ("onion skin" appearance). (a), (b), (c) Hematoxylin and eosin section and (d) CD23 staining.
10.1177_2050313X19839532-fig2.jpg
PMC6448118_01_10.1177_2050313X19839532-fig2.jpg
fig2-2050313X19839532
The vessels penetrated germinal center to form a "lollipop" follicle, and follicular dendritic cells and small lymphocytes form concentric rings ("onion skin" appearance; Figure 2).