PMC9389076_01
Glial fibrillary acidic protein (GFAP-IgG) by GFAP-transfected cell-based immunofluorescence assay. Cells were expressing green fluorescent protein-tagged GFAP (green) and immunostained (red if positive). (A, B, C) Examination of cerebrospinal fluid (CSF) in first admission. (D, E, F) Examination of serum in first admission. (G, H, I) Examination of CSF in second admission. (J, K, L) Examination of serum in second admission. (C, F, I, L) Merged images revealed the colocalization of the GFAP antibody and astrocyte (white arrows) (scale bar=50 mum).
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High titers of GFAP IgG antibodies (1:32) were detected in the CSF but not in the serum (Figures 1A-F). Higher titers of GFAP IgG antibodies (1:32) were detected in the CSF (Figures 1G-L).
FDG PET images. (A) Sagittal and coronal PET/CT show a high concentration in the thoracolumbar segment (white arrow). (B) Axial PET/CT shows an extremely abnormal hypermetabolism of FDG near the T12 thoracolumbar segment (maximum standardized uptake value: 6.321). Axial PET/CT in (C, D) bilateral cervical lymph nodes, (E, F) bilateral axillary lymph nodes, and (G) epididymis.
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T12 level. The maximum standard uptake value (SUVmax) was 6.321, which was significantly higher than that in the normal area of the spinal cord (Figures 2A, B). FDG accumulation also occurred at other sites, such as the bilateral cervical lymph nodes, bilateral axillary lymph nodes, thoracoabdominal pelvic lymph nodes, and epididymis (Figures 2C-G).