PMC5618748_01
Radiographic image of both femurs with arrows pointing towards the fracture lines (the right femur on the left side and the left femur on the right side).
CRIRH2017-3191673.001.jpg
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fig1
Plastic-embedded trichrome-stained pictures of the bone with 20x magnification. The trichrome staining shows wide seams of unmineralized osteoid (red) that covers virtually all trabecular surfaces, suggesting a severe mineralization defect.
CRIRH2017-3191673.002.jpg
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fig2
Fluorescence microscopic pictures of the tetracycline-labeled bone with 20x magnification. A severe mineralization defect is confirmed by an unstained section of the bone under fluorescence microscopy looking for tetracycline labeling which reveals faint fluorescence with a blurred pattern and no evidence of the typical double labeling of the bone matrix.
CRIRH2017-3191673.003.jpg
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fig3
Positron emission tomographic image of the lower extremities showcasing a fluorodeoxyglucose (FDG) avid spot on the plantar surface of the left foot (arrow).
CRIRH2017-3191673.004.jpg
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fig4
Low-power microscopic image (2x) showing a well-delineated tumor consisting of variegated mesenchymal components rich in small vessels with focal myxoid stroma.
CRIRH2017-3191673.005.jpg
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fig5
Low-power microscopic image (10x) showing a tumor consisting of prominent small vessels, myxoid stroma, and scattered osteoclast-type giant cells.
CRIRH2017-3191673.006.jpg
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fig6
High-power microscopic image (40x) showing a tumor consisting of bland spindle cells sitting in slightly myxoid stroma with an osteoclast-type giant cell.
CRIRH2017-3191673.007.jpg
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fig7