PMC7568610_01
PMC7568610_02
Patient's Cushing phenotype. (A) before mifepristone treatment; and (B) after treatment for one year.
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Physical examinations revealed that he presented centripetal obesity, moon face, buffalo hump, and purple striae (Figure 1A). After one year of treatment with mifepristone (Table 3, Figure 1B), the patient's body weight decreased from 95 kg to 93 kg.
(A) Pituitary magnetic resonance imaging showing normal pituitary anatomy; (B) Adrenal computed tomography scan showing atrophic adrenals.
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Pituitary magnetic resonance imaging showed normal pituitary anatomy (Figure 2A), while the adrenal computed tomography scan showed bilateral adrenal atrophy and increased content of intra-abdominal fat and abdominal subcutaneous fat (Figure 2B).
RT-PCR results for the patient and two normal, age-matched men at three different time points. The results were normalized with the patient's relative mRNA level as 1. *P<0.05.
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However, the difference of the mRNA levels of other indices between the patient and the normal, age-matched males was not significant (Figure 3).