PMC8081640_01
The tumour showing mixed morphologic features with haphazardly arranged, irregularly shaped glands enmeshed in fibrotic stroma typical of cholangiocarcinoma (a) as well as sheet-like growth of solid cell nests and trabeculae showing morphologic and immunohistochemical evidence of hepatocellular differentiation (b).
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fig1
The cirrhotic liver contained a 1.5 cm firm white tumor that showed morphologic and immunohistochemical features of a combined hepatocellular-cholangiocarcinoma (Figure 1).
PMC8081640_02
The tumour composed of variably sized nests and trabeculae associated with desmoplasia (arrow) and hemorrhage. (a) High-grade tumour cells containing enlarged, hyperchromatic nuclei with relatively scant cytoplasm extensive necrosis. (b) The high-grade areas are positive for cytokeratin-7 and show patchy staining for arginase and Hepar-1.
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fig2
The carcinoma showed hepatocellular differentiation as well as undifferentiated components (Figure 2).
PMC8081640_03
This hepatocellular carcinoma containing broad trabaculae of tumour cells with abundant clear cytoplasm (a). Other high-grade areas resembling conventional hepatocellular carcinoma (b).
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fig3
Most (>80%) of the tumor cells contained abundant clear cytoplasm with some higher grade areas (Figure 3).
PMC8081640_04
Sheets of tumour cells arranged in cystically dilated glands (a) that contain brightly eosinophilic secretions reminiscent of colloid (b).
CRIHEP2021-6654229.004.jpg
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fig4
Sheets of tumor cells were arranged in large, cystically dilated glands filled with eosinophilic material reminiscent of colloid seen in thyroid follicles (Figure 4).
PMC8081640_05
Infiltrating malignant glands are intimately associated with a dense lymphoid infiltrate (a). Intraepithelial lymphocytes are also present (b) ().
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fig5
The malignant glands were associated with a dense lymphoid infiltrate and tumor-infiltrating lymphocytes (Figure 5).