PMC6120344_01
A: Intracranial EEG with recordings from left amygdala-hippocampus, orbitofrontal, insula and lateral temporal regions. Electrical stimulation artifact (highlighted) in hippocampal channels followed by an induced seizure. Co-registered MRI to demonstrate the orthogonal trajectory of left hippocampal depth electrode. B: Serial cognitive test performances in percentile. C: Spectrogram (1-100 Hz) showing seizure in the hippocampal channel and spread to orbitofrontal regions.
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Stimulation of left anterior and posterior hippocampus separately at 2 mA induced electroclinical seizures that lasted 50-70 s (Fig. 1A). The patient was a able to follow the motor command "lift your left arm." Postictally, the patient, failed to recall the three objects, was unable to recall being tested but was oriented and attentive (Fig. 1B). Time-frequency analysis (spectrogram) of pre-processed EEG during an induced seizure with bandwidth 1-100 Hz showed increased power up to high gamma (100 Hz) in hippocampus and beta range (20 Hz) in ipsilateral orbitofrontal channels (Fig. 1C).