PMC10331325_01
(a) Histerectomy. Muticystic well demarcated mucinous mass with distortion of the cervix. (b) Section of the tumor. (c) HE, 100x. A larger cystic gland surrounded by smaller glands in a lobular configuration. (d) HE, 200x. The glands were lined by a single layer of tall, mucin-rich, columnar cells with basal and bland nuclei (pyloric metaplasia). (e) IHC MUC6. The lesion was positive for MUC6, a typical marker of pyloric glands. (f) IHC Estrogen Receptor. The lesion was negative for estrogen and progesterone receptors.
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Macroscopic findings indicated that a well demarcated multicystic mucinous mass affected the entire cervix. (Figure 1(a) and (b)) Microscopic examination showed endocervical glandular proliferation with a strikingly lobular architecture (Figure 1(c)). The stroma did not show desmoplasia and was inconspicuous (Figure 1(d)). Immunohistochemistry (IHC) was performed, and the lesion was found to be diffusively positive for MUC6 (Figure 1(e)) and negative for estrogen and progesterone receptors (Figure 1(f)).