PMC5137644_01
Histological appearances of the colon: partial to full-thickness (arrow) ischaemic mucosal necrosis and submucosal oedema (x10 magnification) (A); haemorrhagic necrosis of the mucosa in areas (x20 magnification) (B), and extension of inflammation and oedema into the muscularis propria (x20 magnification) (C)
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fig1
Histological examination showed extensive ischaemic change in the colonic wall with minimal inflammation and normal blood vessels (Fig 1).
Gomori trichrome preparation showing scattered 'ragged red' fibres
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fig2
A subsequent skeletal muscle biopsy revealed ragged red fibres (Fig 2), cytochrome c oxidase-negative fibres, succinate dehydrogenase hyperreactive blood vessels and paracrystalline arrays in mitochondria.