PMC7476449_01
A, Erythematous brownish patches and plaques involving less than 10% of body surface (Ia stage mycosis fungoides; T1N0M0B0). B, Histology of the same lesion, revealing epidermotropism, lymphocyte alignment at the basement membrane zone, and Pautrier's microabscesses (hematoxylin and eosin, x100).
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The patient had a family history of psoriasis, and the presumed diagnosis was psoriasiform dermatitis/pre-MF/MF (Figure 1a). Skin biopsy and histologic confirmation of MF were obtained only in June 2020 (Figure 1b); meanwhile, the patient has been treated with topical corticosteroids.
PMC7476449_02
Disease course before and after radiotherapy: A, initial solitary tumor lesion on the back; B, almost complete disappearance after radiotherapy; C, disease progression and dissemination with multiple tumorous nodules 2 months later.
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IIB) in January 2020, with a single positron emission tomography/computed tomography-active tumor lesion on the back (Figure 2a). In March 2020, she underwent successful local radiation therapy (25 Gy in five fractions) with satisfactory effect (Figure 2b). In May 2020, the disease rapidly worsened with the appearance of multiple new tumor lesions suggestive of large cell transformation of MF (Figure 2c).