PMC7117631_01
(A) Ulcerated lesion on the mucosal side of the lower lip. (B) Nodular lesion on the skin.
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F1
However, on the oral mucosal side, the lesion was ulcerative centrally (Fig. 1A, Fig. 1B).
Bicellular architecture, outer clear polygonal myoepithelial cells and inner cuboidal duct-like cells.
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F2
The tumor showed bicellular architecture, clear polygonal myoepithelial cells and cells forming duct with round central nuclei (Fig. 2).
EMA staining in ductal cells. On the left side, there is no staining in myoepithelial cells.
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F3
Immunohistochemically, epithelial cells forming duct were positive for EMA (Fig. 3), Pan-CK, CK7, the myoepithelial cells were positive for p63, p40 (Fig. 4), HMWCK (Fig. 5), CK5/6.
Myoepithelial cells stain with HMWCK at the bottom. In the middle of the figure, ductal cells do not express HMWCK.
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F5
Immunohistochemically, epithelial cells forming duct were positive for EMA (Fig. 3), Pan-CK, CK7, the myoepithelial cells were positive for p63, p40 (Fig. 4), HMWCK (Fig. 5), CK5/6.
Ki-67 index is 5% in the most intense area.
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F6
Ki-67 index was %5 (Fig. 6) and p53 had wild type expression.
Verrucous carcinoma. Parakeratosis, acanthosis, verrucous growth pattern, mitosis on the basal and middle layer and minimal loss of polarity are seen. There is no invasion here.
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F7
In two vocal cords, there were verrucous carcinoma (Fig. 7).
Microinvasion of verrucous carcinoma in the left vocal cord.
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F8
In the left vocal cord, microinvasion was seen (Fig. 8).