PMC7871728_01
PMC7871728_02
PMC7871728_03
Brain tissue histology. Evidence of significant neuronal loss was present throughout the caudate and putamen (top left, H&E, 40x). There was also presence of diffuse and neuritic plaques (top right, amyloid-beta 42 antibody, 20x) and rare ubiquitin inclusions (bottom left, black arrow, ubiquitin, 63x). Finally, staining with p62 demonstrated minimal nuclear inclusions (bottom right, white arrows, p62, 40x).
bmjno-2019-000027f01.jpg
PMC7871728_03_bmjno-2019-000027f01.jpg
F1
This revealed classic HD findings including caudate atrophy, severe neuronal loss in the basal ganglia (particularly caudate and putamen), with concomitant gliosis in these areas (figure 1). p62 showed rare intraneuronal inclusions thus suggesting minimal huntingtin aggregation (figure 1). Interestingly, Alzheimer type pathology was also identified consisting of amyloid-beta plaques (Thal-phase IV staging) and tau neuronal degeneration of the medial temporal lobe (Braak stage II) (figure 1).