PMC4317191_01
MRI and histochemical findings: (A) cMRI (t1) showing generalised brain volume reduction. (B) Histochemical demonstration of sequential COX and SDH activities revealing numerous COX-deficient (blue reaction product) fibres and evidence of subsarcolemmal mitochondrial proliferation.
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Minimental state examination, however, showed normal results. cMRI showed generalised brain volume reduction (Fig. 1A).