PMC524360_01
Sagittal MRI image of brain at first cerebral relapse demonstrating an enhancing left parasagittal lesion with surrounding cerebral oedema.
1471-2407-4-74-1.jpg
PMC524360_01_1471-2407-4-74-1.jpg
F1
MRI of the brain and spine demonstrated a left parasagittal tumor with radiographic features consistent with a meningioma (see Figure 1).
Photomicrograph of cerebral metastases showing sheets of epithelioid and spindle cells, (H&E x 200)
1471-2407-4-74-2.jpg
PMC524360_01_1471-2407-4-74-2.jpg
F2
Histopathology demonstrated metastatic GIST (CD117 positive) (see Figures 2 and 3).
Immunohistochemical stain for CD117 (c-kit) showing staining of the cell membrane and Golgi region of the tumor cells, (x 400)
1471-2407-4-74-3.jpg
PMC524360_01_1471-2407-4-74-3.jpg
F3
Histopathology demonstrated metastatic GIST (CD117 positive) (see Figures 2 and 3).
DNA sequence of part of exon 9 of c-kit for control (lower) and patient tumour (upper) samples. The patient's tumour sample contained a GCCTAT duplication
1471-2407-4-74-4.jpg
PMC524360_01_1471-2407-4-74-4.jpg
F4
An in-frame GCCTAT insertion/duplication in exon 9 of c-kit in the original jejunal tumor, the liver and the cerebral metastases were detected (See Figure 4).