PMC8348553_01
A: Bronchoscopic appearance. The tumor can be seen in the bronchus intermedius. B: After neodymium yttrium aluminum garnet laser surgery. C: Chest computed tomography shows the endobronchial recurrence of the tumor in the bronchus intermedius. D: Bronchoscopic appearance. The recurrent tumor was in the same location.
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Bronchoscopy revealed a protuberant 2.0-cm tumor in the intermediate bronchus (Fig. 1A). The tumor was resected using a high-frequency electrosurgical snare and bronchoscopic neodymium yttrium aluminum garnet (Nd-YAG) laser surgery in another hospital (Fig. 1B). The tumor was present in the same place (1.0 cm in diameter) in the intermediate bronchus (Fig. 1D).
A, B: Histopathological findings of the tumor. The tumor is composed of squamous, mucous, and intermediate cells, with no clear findings of mitosis or necrosis. C, D: Immunostaining showed that the non-mucus-producing cells were positive for 34betaE12 and showed nuclear staining of p63.
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The non-mucus-producing cells were positive for 34betaE12 and showed nuclear staining of p63; therefore, the diagnosis was recurrence of MEC (Fig. 2).
A: Photodynamic diagnosis with the SAFE-3000 before photodynamic therapy. B: No evidence of tumor recurrence 5 years after photodynamic therapy.
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Four hours after administration of Laserphyrin, we administered local anesthesia with 4% xylocaine, inserted a fiber similar to bronchofiberscopy and performed PDT (Fig. 3A).