PMC4821325_01
Sclerosing Pneumocytoma (H&E). Well circumscribed non encapsulated intrapulmonary tumour compressing the adjacent lung parenchyma, showing papillaroid, sclerotic, solid and angiomatoid areas. There are no areas of necrosis. (a) Sclerosing pneomocytoma (H&E X12.5 Magnification) Well circumscribed unencapsulated haemorrhagic intrasclerosing mass. (b) Sclerosing pneumocytoma (H&E X100 Magnification) Sclerotic and papillaroid areas. (c) Sclerosing pneumocytoma (H&E X100 Magnification) Hypercellular areas. (d) Sclerosing pneumocytoma (H&E X100 Magnification) Angiomatoid and haemorrhagic areas. (e) Sclerosing pneumocytoma (H&E X200 Magnification) Papillaroid areas.
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On microscopic examination the lesion showed a variegated appearance with papillaroid, sclerotic, solid and angiomatoid areas (Fig. 1a-e). No mitotic figures are observed and the mib-1 proliferation index is less than 1% (Fig. 2e).
Sclerosing Pneumocytoma (Immunohistochemistry). AE1/AE3 highlights the presence of a rim of cells lining the angiomatoid and papillaroid areas and a second population of cells found in the intervening spaces which are AE1/AE3 negative. Both cellular components express EMA and TTF-1. (a) Sclerosing Pneumocytoma AE1/AE X100 Magnification. (b) Sclerosing Pneumocytoma EMA X100 Magnification. (c) Sclerosing Pneumocytoma TTF-1x100 magnification. (d) Sclerosing Pneumocytoma CD34x100 Magnification. (e) Sclerosing Pneumocytoma Mib-1x100 Magnification.
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TTF-1 (Fig. 2a-c). A second cell population is observed in the intervening stroma. None of the cells express CD31 or CD34 (Fig. 2d).