PMC3937008_01
QEEG brainwave activity Z-scored for age and absolute power. Approximately 2 minutes of artifact free EEG was used to derive the absolute power for total power, delta (1-3.5 Hz), theta (3.6-7.5 Hz), alpha (7.6-12.5 Hz), beta (12.6-25 Hz), and beta2 (25.1-35 Hz). The -3.0 to 3.0 color scale indicates Z-scores (standard deviations) away from age-adjusted normal absolute power of the EEG brainwave activity. Areas of excessive brainwave power in each frequency band are colored yellow, orange and red, and blue and green areas indicate reduced activity. The color black indicates normal activity. (A) Brain map images 2 years before starting BART. (B) Brain map images 4 weeks after starting BART.
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To produce the maps shown in Figure 1, digital raw EEG information was used for derive measures of deviation from age matched normal using BrainDx1 software. Significant Z-score deviations from age expected normal values with widespread excess theta maximum in the temporal regions are shown in Figure 1A. Changes toward normal (black) as compared with the baseline state of Figure 1A are shown in the Z-scores for absolute power measures following BART intervention of Figure 1B. The brainwave Z-scored activity 4 months after BART (Figure 1B) indicates a normalization of all scores across all bandwidths for absolute power.
sLORETA maps of maximum and minimum activity (corrected for age). Two minutes of artifact free EEG was used to calculate Z-scores for the over 6,000 voxels of current density in the sLORETA calculations. Colors indicate brain regions showing significant increased (red) or decreased (blue) activity for age. (A) Images prior to starting BART showing probable sources for the maximum excess abnormality in the (7.35 Hz) theta band (top panel) and deficit activity in the (23.7 Hz) beta band (bottom panel). (B) Images 4 weeks after starting BART showing probable sources for the maximum excess activation in the (6.96 Hz) theta band (top panel) and maximum deactivation in the (24.51 Hz) beta band (bottom panel).
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The sLORETA 3-D images of Figure 2 show maximum Z-score for excess activation was found to be located at Brodman Area 44, Precentral Gyrus, and Frontal Lobe. Comparing Figure 2A and 2B, a clear change toward more normal activity of the sources can be seen after starting BART.