PMC10025567_01
Gastric antrum.
fonc-13-1114097-g001.jpg
PMC10025567_01_fonc-13-1114097-g001.jpg
f1
The other colonic and rectal mucosa were smooth, with clear vascular texture and no obvious abnormalities.  Figures 1 - 4  show the patient's condition under a gastroscope.
Gastric fundus.
fonc-13-1114097-g002.jpg
PMC10025567_01_fonc-13-1114097-g002.jpg
f2
The other colonic and rectal mucosa were smooth, with clear vascular texture and no obvious abnormalities.  Figures 1 - 4  show the patient's condition under a gastroscope.
Gastric body.
fonc-13-1114097-g003.jpg
PMC10025567_01_fonc-13-1114097-g003.jpg
f3
The other colonic and rectal mucosa were smooth, with clear vascular texture and no obvious abnormalities.  Figures 1 - 4  show the patient's condition under a gastroscope.
Gastric body.
fonc-13-1114097-g004.jpg
PMC10025567_01_fonc-13-1114097-g004.jpg
f4
The other colonic and rectal mucosa were smooth, with clear vascular texture and no obvious abnormalities.  Figures 1 - 4  show the patient's condition under a gastroscope.
Under the microscope, the glandular cavity of the gastric body is irregular in shape, manifested as expansion or distortion, and there are small glandular cavities around, mucosal interstitial edema, accompanied by infiltration of chronic inflammatory cells. (A. 40x; B. 200x).
fonc-13-1114097-g005.jpg
PMC10025567_01_fonc-13-1114097-g005.jpg
f5
Pathological findings suggest the following: 1. (gastric fundus biopsy) mucosa high-grade intraepithelial neoplasia; 2. (gastric biopsy) juvenile polyps ( Figure 5 ); 3. (sigmoid colon biopsy) Low-grade tubular adenoma with clean margins.
Schematic diagram of SMAD4 gene pathogenic variant.
fonc-13-1114097-g006.jpg
PMC10025567_01_fonc-13-1114097-g006.jpg
f6
Gene testing of the patient and his brother showed that the SMAD4: c.266_269del pathogenic variant was present in exon 3 of the SMAD4 gene ( Figure 6 ).