PMC7114650_01
Primary melanoma of the cornea; A), B) and C) corneal pigmented lesion, clearly demarcated and surrounded by clear cornea, with two feeder vessels derived from the limbus; D) inability of complete eyelid closure
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F1
Hospital, Greece, complaining of gradual vision deterioration, pain, and inability of complete eyelid closure (Figure 1 D (Fig. 1)) of her right eye (OD). Her ophthalmic history revealed cataract surgery OD three years before, followed by an unspecified postoperative complication. Two feeder vessels passed through the limbus onto the lesion (Figure 1A-C (Fig. 1)).
Imaging which did not reveal associated pathology; A), B), C) and D) A- and B-scan; E) and F) UBM - lesion sparing posterior stroma and endothelium; (courtesy of Dr. Miltos Balidis, OPTHALMICA Eye Institute)
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F2
AS-OCT; A) preoperative; B) post-operative
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F3
An uncomplicated postoperative period followed, as is documented in the AS OCT (Figure 3B (Fig. 3)) and photographs taken on postoperative day 1 (Figure 4A and
Photographs taken post-operatively; A) and B) day 1; C) and D) week 6; E), F) and G) week 8
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F4
B (Fig. 4)), week 6 (Figure 4C and D (Fig. 4)) and week 8 (Figure 4E-G (Fig. 4)). Best corrected visual acuity reached 6/10.
Histologic features; A) low-power view of the neoplasm, hematoxylin-eosin, x100; B) high-power view illustrating the cytologic features of the tumor cells, hematoxylin-eosin, x400; C) positive immunostaining of the tumor cells for Melan-A antigen, automated immunohistochemistry, x400; (courtesy of Prof. Prodromos Chitiroglou, Pathology Department, Aristotle University of Thessaloniki, Greece)
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F5
Hematoxylin- and eosin-stained sections revealed malignant corneal tissue involving the junction of the epithelium and the lamina propria, as well as the underlying connective tissue in its full thickness (Figure 5A (Fig. 5)). The neoplasm consisted of large-sized, round, polygonal, and spindle cells, with eosinophilic cytoplasm and hyperchromatic, markedly pleomorphic nuclei, with large nucleoli (Figure 5B (Fig. 5)). The tumor cells contained numerous cytoplasmic melanin granules (Figure 5A and B (Fig. 5)). Immunohistochemical stains revealed tumor cell diffuse positivity for HMB45 and Melan-A antigens (Figure 5C (Fig. 5)).