PMC8529000_01
FDG-PET/CT. FDG uptake was detected in almost all bone segments (A) and in breast lesions (B) before treatment.
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An 18-fluorodeoxyglucose-positron emission tomography computed tomography (FDG-PET/CT) showed uptake with activation of the bone marrow in all bone segments, a nuanced uptake in bilateral breast and a pelvic ascitic effusion ( Figures 1A ,  B ).
FDG-PET/CT. Completely disappeared bone (A) and breast (B) uptake was observed after five months of AI, LH-RHa and CDK4/6 inhibitor.
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PET/CT scan showed the resolution of the hypermetabolic breast tumors and bone metastatic foci with the disappearance of the ascitic effusion ( Figures 2A, B ). Patient's subsequent PET/CT imaging every 6 months confirmed complete response to ongoing treatment with last PET/CT performed in June 2020.
Relevant clinical data and therapies from diagnosis till now organized as a timeline.
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Timeline of relevant clinical data and therapies are presented in  Figure 3 .