PMC5943687_01
(A, B and C): Clinical aspect and X-rays of case 1. (A): show severe enlargement of cranial bones. (B): Lateral view of mandible, note radiotrasparency of cancellous bone. (C): Medio-Lateral view of proximal front limb, with bone loss consistency and soft tissue mineralization. (D, E and F): X-rays of Case 2. (D and E): respectively CdCr view and LM oblique view of stifle joint. (F): LM view of tibia. Notable soft tissue mineralization and bone demineralization
OpenVetJ-8-149-g001.jpg
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F1
The radiological findings were compatible with fibrous osteodystrophy and soft tissue mineralization (Fig. 1D, Fig. 1E, F).
PMC5943687_02
(A, B and C): Clinical aspect and X-rays of case 1. (A): show severe enlargement of cranial bones. (B): Lateral view of mandible, note radiotrasparency of cancellous bone. (C): Medio-Lateral view of proximal front limb, with bone loss consistency and soft tissue mineralization. (D, E and F): X-rays of Case 2. (D and E): respectively CdCr view and LM oblique view of stifle joint. (F): LM view of tibia. Notable soft tissue mineralization and bone demineralization
OpenVetJ-8-149-g001.jpg
PMC5943687_02_OpenVetJ-8-149-g001.jpg
F1
The radiological findings were compatible with fibrous osteodystrophy and soft tissue mineralization (Fig. 1D, Fig. 1E, F).
Contact microradiographs: poorly mineralized matrix appears more radiotransparent than normal matrix. (A and B): bone architecture is modified because of increased trabecular loss (asterisk) and large areas of surface erosion (empty arrows) affecting spongy and subchondral bone. (C): thin trabeculae (thin arrow) are forming in front of Howship's lacunae. (D): the erosion and, on the opposite side of the same trabecula, a deposition front, reflect high bone turnover. Large osteocytic lacunae are visible. [magnification: (A and B): 4x; (C): 10x; (D): 20x].
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F2
The new matrix was laid down upon the surface of pre-existing bone or appeared as new small, fragmented trabeculae (Fig. 2).
Nondemineralized bone sections (toluidine blue stain). (A): osteoclasts and mast cell showing extrusion of metachromatic granules (thin arrow). A round mast cell in the bone marrow (empty arrow). (B): plump fibroblast-like preosteoblasts (arrow) surround a poorly organized bone matrix. (C): bone-forming surface with a wide unmineralized osteoid seam lined by osteoblasts. (D): numerous cement lines delimit the bone fragments, giving a mosaic appearance to the section. (E): the marrow spaces are replaced by fibrocellular tissue. [magnification: (A and C): 40x; (B and E): 10x; (D): 20x].
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F3