PMC6198890_01
VA and CRT over time following treatment with repeated injections of the DEX (n=4) and FAc implant (n=2).. Notes: Intravitreal injections of DEX and FAc implants are shown in green and blue, respectively. The patient was re-treated with a second FAc implant in April 2017.. Abbreviations: CRT, central retinal thickness; DEX, dexamethasone; ETDRS, Early Treatment Diabetic Retinopathy Study; FAc, fluocinolone acetonide; OCT, optical coherence tomography; VA, visual acuity.
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Ranibizumab was administered twice (March 2011 and April 2011) before the patient was treated with his first DEX implant in October 2011 (Table 2 and Figure 1). A second and third implant were administered in May 2012 (50 letters and 676 microns) and November 2012 (60 letters and 592 microns) at which points VA remained relatively stable irrespective of treatment, and recurrence of edema was seen within 6-7 months of the DEX implant being injected (Table 2 and Figure 1). FAc implant was injected after CRT had again rebounded within 7 months of the fourth DEX implant being given (to 748 microns) and VA had started to worsen (50 letters). Figure 1 highlights the impact of FAc implant in this patient with CRT remaining below 300 microns until October 2016 (30 months) and VA being stable between 65 and 70 letters.