PMC10228747_01
HE and IHC staining of the EBUS examination and biopsy. (A) HE staining showing tumor cells lined in papillary or nested pattern. Cells were with rich and eosinophilic cytoplasm as well as with heteromorphic nuclear. (B) IHC test showing tumor cell positive for CR.
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Figure 1 ). Further abdominal CT discovered no distant organ metastasis.
CT image during anlotinib treatment and after disease progression. (A, B) CT obtained on 3 March 2019, 4 months after initiating anlotinib treatment. Images showed soft tissue density mass in the posterior mediastinum and the range of the mass remained stable during anlotinib treatment. (C, D) CT image on 2 October 2020. Images showed enlarged posterior mediastinum mass, together with pleural effusion and pericardial effusion, indicating disease progression.
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Enhanced chest CT scan was performed every 3 months to evaluate treatment response, and part of the results is shown in  Figure 2 .
A summary of the treatment course of the patient.
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The summary of the whole treatment course is listed in  Figure 3 .