PMC4899564_01
6-day-old infant with methylmalonic acidemia. Sequential mean diffusion images derived from diffusion tensor imaging showed symmetric diffusion restriction in the subcortical white matter of bilateral cerebral hemispheres, with sparing of the peri-Rolandic regions. Note that there was no abnormal signal along the basal ganglia, and specifically along the globus pallidi.
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fig1
See Figures 1-4, Figures 5-6, Figure 7.
6-day-old infant with methylmalonic acidemia. On figure 5, the T2-weighted image demonstrated lack of intensity abnormality in bilateral basal ganglia, including the globus pallidi. On figure 6, an apparent diffusion coefficient map again illustrated markedly reduced diffusion.
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PMC4899564_01_gr5.jpg
fig5
See Figures 1-4, Figures 5-6, Figure 7.
6-day-old infant with methylmalonic acidemia. Spectroscopy demonstrated an elevated lipid/lactate peak (1.3 ppm), a finding commonly seen in the setting of methylmalonic acidemia.
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fig7
See Figures 1-4, Figures 5-6, Figure 7.