PMC5429914_01
(a, b, c, d) Erythematous papules, plaques, hemorrhagic ulcerations, and atrophic scars in different sizes scattered all over the body.
CRIDM2017-3194738.001.jpg
PMC5429914_01_CRIDM2017-3194738.001.jpg
fig1
A 18-year-old female presented to the outpatient clinic of dermatology with a 15-year history of waxing and waning course of erythematous papules, plaques, hemorrhagic ulcerations, and atrophic scars (Figures 1(a), 1(b), 1(c), and 1(d)).
(a, b) Regular acanthotic epidermis, a dense dermal infiltrate of pleomorphic atypical lymphoid cells, and destruction of the blood vessels' walls by abnormal lymphocytes. (c) The cells were strongly positive for CD30.
CRIDM2017-3194738.002.jpg
PMC5429914_01_CRIDM2017-3194738.002.jpg
fig2
The skin biopsy revealed regular acanthotic epidermis, a dense dermal infiltrate of pleomorphic atypical lymphoid cells, and destruction of the blood vessels' walls by abnormal lymphocytes (Figures 2(a) and 2(b)). Biopsy revealed abnormal lymphocytes which were predominantly positive for CD30 (Figure 2(c)) and mostly CD8+ lymphoid cells, especially angiocentric infiltrates.
(a, b, c) All previous persistent lesions were healed completely and no new lesions were observed after two-month treatment with IFN alfa-2a.
CRIDM2017-3194738.003.jpg
PMC5429914_01_CRIDM2017-3194738.003.jpg
fig3
After two-month treatment with IFN alfa-2a, she was finally feeling well and there were no new lesions and all previous persistent lesions were healed completely (Figures 3(a), 3(b), and 3(c)).