PMC9524378_01
Liver computed tomography images. (A) PET-CT scan revealed that the largest liver mass was 5.5x10.1 cm before treatment. (B) CT reexamination showed that the largest liver mass was shrunken to 5.9x3.0 cm after 8 weeks of treatment. (C) CT reexamination showed that the largest liver mass was shrunken to 4.5x1.8 cm after 16 weeks of treatment. (D) CT reexamination showed that the largest liver mass had been stable at 4.5x1.8 cm after 24 weeks of treatment. (E) CT reexamination showed that the largest liver mass was shrunken to 1.8x1.8 cm after 32 weeks of treatment.
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There were multiple low-density shadows in the liver (standard uptake value (SUV) 16.5) with a maximum of 5.5x10.1 cm (Figure 1A) and multiple pulmonary nodules (SUV 7.3) with a maximum of 1.8x2.0 cm (Figure 2A) on PET-CT scan. After two months of treatment, follow-up CT reexamination showed that the largest lung mass had shrunken to 1.0x0.8 cm (Figure 2B) and the largest liver mass was significantly reduced to 5.9x3.0 cm (Figure 1B). Abdominal CT scan showed that the largest liver mass had shrunk to 4.5x1.8 cm at 16 and 24 weeks of treatment (Figure 1C-D) and 1.8x1.8 cm at 32 weeks of treatment (Figure 1E).
Chest computed tomography images. (A) PET-CT scan revealed that the largest pulmonary nodule was 1.8x2.0 cm before treatment. (B) CT reexamination showed that the largest pulmonary nodule had shrunken to 1.0x0.8 cm after 8 weeks of treatment. (C-E) CT reexamination showed that the largest pulmonary nodule had been stable at 1.0x0.8 cm after 16, 24 and 32 weeks of treatment.
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There were multiple low-density shadows in the liver (standard uptake value (SUV) 16.5) with a maximum of 5.5x10.1 cm (Figure 1A) and multiple pulmonary nodules (SUV 7.3) with a maximum of 1.8x2.0 cm (Figure 2A) on PET-CT scan. After two months of treatment, follow-up CT reexamination showed that the largest lung mass had shrunken to 1.0x0.8 cm (Figure 2B) and the largest liver mass was significantly reduced to 5.9x3.0 cm (Figure 1B). Follow-up CT re-examination demonstrated no significant changes in lung mass since the last review (Figure 2C-E).
Hematoxylin and eosin staining. (A) low differentiated adenocarcinoma with signet ring cell carcinomatous conformation in the biopsy specimen of liver. (B) poorly differentiated adenocarcinoma in the biopsy specimen of colonic polyp.
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Pathology showed a poorly differentiated adenocarcinoma with a signet ring cell carcinomatous conformation (Figure 3A), but immunohistochemical staining did not identify the original source of tumor cells. The result of the histopathological examination of the colonic polyp demonstrated poorly differentiated adenocarcinoma (Figure 3B).