PMC6597736_01
(A,B) Chest computed tomography of the first visit showed consolidations with halo sign in the right lower lobe. (C,D) The shadow progressed six days later.
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fig1
Histological findings of the TBLC specimens.. (A) Intra-alveolar fibrin deposition within the alveolar spaces. Fibrin account for over three quarters of specimen (Hematoxylin and eosin staining, x 1). PA: pulmonary artery, MB: Membranous bronchioles. (B) This lesion was characterized by Intra-alveolar fibrin in the form of fibrin 'balls' and interstitial inflammation without formation of hyaline membranes (Hematoxylin and eosin staining, x 10).  fibrin balls. (C) This lesion showed accumulation of fibrin and occasional intra-alveolar polypoid fibrosis in alveolar spaces (Alcian blue and PAS staining, x 10).  polypoid fibrosis. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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Histological study of these specimens showed intra-alveolar fibrin balls, involving more than three quarters of alveolar space and mononuclear cells infiltration without eosinophils and formation of hyaline membranes (Fig. 2A-C), indicating AFOP.