PMC3352177_01
Computed tomographic scan of the brain shows an osteolytic tumor in the right frontal region (a). Coronal (b) and sagittal (c) T1-weighted magnetic resonance images with gadolinium-diethylenetriaminepenta-acetic acid revealing a heterogeneously enhanced tumor in the right frontal region with perifocal edema. The tumor was attached to the wall of the superior sagittal sinus and dura. Computed tomographic scan of the chest reveals an endobronchial growth in the hilum of the right upper lobe (d).
CRIM.ONCMED2011-610383.001.jpg
PMC3352177_01_CRIM.ONCMED2011-610383.001.jpg
fig1
Skull radiography and computed tomography (CT) showed an osteolytic tumor in the right frontal bone (Figure 1(a)). T2-weighted images, which was enhanced heterogeneously by gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA). The tumor was attached to the wall of the superior sagittal sinus and dura of the right frontal lobe (Figures 1(b) and 1(c)). The preoperative workup included CT of the chest, abdomen, and pelvis, which demonstrated a right lung tumor with subcarinal lymph node swelling and pulmonary emphysema (Figure 1(d)).
Intraoperative photographs of the tumor. (a) Complete exposure of the tumor covered by the periosteum. (b) Resected tumor with bone.
CRIM.ONCMED2011-610383.002.jpg
PMC3352177_01_CRIM.ONCMED2011-610383.002.jpg
fig2
The tumor was excised through the periosteum covering the bone (Figure 2(a)), and the margins were negative (Figure 2(b)).
(a) Tubular structures with an inner layer of cuboidal epithelial cells and an outer layer of myoepithelial cells with clear cytoplasm. Mitoses were not conspicuous (hematoxylin-eosin, original magnification x200). (b) Immunoreactivity in epithelial cells for cytokeratin (original magnification x200). (c) Immunoreactivity in myoepithelial cells for p63 (original magnification x200). (d) Immunoreactivity for the MIB-1 was about 10% (original magnification x200).
CRIM.ONCMED2011-610383.003.jpg
PMC3352177_01_CRIM.ONCMED2011-610383.003.jpg
fig3
The outer cells were round or polygonal and exhibited either clear or eosinophilic cytoplasm (Figure 3(a)). The inner cells showed immunoreactivity for cytokeratins (Figure 3(b)). TTF-1. The MIB-1 labeling index was approximately 10% in myoepithelial cells (Figure 3(d)).