PMC10359687_01
Brain magnetic resonance images of the current patient. Sagittal T1-weighted image (a), fluid-attenuated inversion recovery (FLAIR) images (b-d), and diffusion-weighted images (DWIs) (e-g) showing atrophy in the cerebrum, brainstem, and cerebellum. FLAIR axial images showing a mild bilateral high-intensity signal in the middle cerebellar peduncle (b) and a diffuse high-intensity signal in bilateral cerebral white matter (c, d). f, g DWI axial images showing a high-intensity signal along the corticomedullary junction.
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F1
Battery score was 9 out of 18. Brain magnetic resonance imaging revealed atrophy in the cerebrum, brainstem, and cerebellum (Fig. 1a-g). Mild bilateral high-intensity signals in the middle cerebellar peduncle (Fig. 1b) and a diffuse high-intensity signal in the cerebral white matter (Fig. 1c-d) were observed on fluid-attenuated inversion recovery imaging. A high-intensity signal was observed along the corticomedullary junction on diffusion-weighted imaging (Fig. 1f-g). 123I-ioflupane dopamine transporter single-photon emission computed tomography demonstrated a reduced uptake in the bilateral striata; the specific binding ratios in the right and left striata were 3.94 and 3.82, respectively (Fig. 2a).
Brain 123I-ioflupane dopamine transporter (DAT) and N-isopropyl-p-(123I)-iodoamphetamine (IMP) single-photon emission computed tomography (SPECT) findings. a DAT-SPECT showing a decreased radiotracer uptake in the bilateral striata. b IMP-SPECT indicating hypoperfusion in the cerebral cortices with frontal predominance.
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F2
A high-intensity signal was observed along the corticomedullary junction on diffusion-weighted imaging (Fig. 1f-g). 123I-ioflupane dopamine transporter single-photon emission computed tomography demonstrated a reduced uptake in the bilateral striata; the specific binding ratios in the right and left striata were 3.94 and 3.82, respectively (Fig. 2a). N-isopropyl-p-(123I)-iodoamphetamine single-photon emission computed tomography revealed hypoperfusion in the cerebral cortices with frontal lobe predominance (Fig. 2b).