PMC3618054_01
Inflammatory pseudotumour located in the spleen.
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F1
In the late venous phase, the tumour enhanced the contrast almost completely and was isoattenuating (fig. 1).
Clinical course of MPGN associated with pseudotumour in the spleen.
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F2
Treatment with captopril and furosemide was instituted (fig. 2).
PAS-silver stain of a representative glomerulus. The renal biopsy contained cortex with 14 glomeruli with a pronounced accentuation of the lobules. There was a mesangial matrix and cell increase (arrow), and in some capillaries double contours can be seen (arrowheads) forming a membranoproliferative pattern. No crescents were observed. Immunofluorescence (not shown) showed predominantly membranous, granular deposits of C3c and IgG and lower amounts of IgM, IgA and C1q. Electron microscopy (not shown) demonstrated modest but distinct electron-dense deposits in the subendothelial zone and scattered subepithelial deposits. There was a mesangial cell proliferation and focal interpositioning in the thickened capillary walls. The final morphological diagnosis was MPGN type I.
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F3
A diagnosis of MPGN type I was obtained (fig. 3) and the plasmapheresis procedure was discontinued after 2 treatment sessions.