PMC4904703_01
(a) Biopsy of the duodenum reveals villous blunting and expansion of the lamina propria inflammatory infiltrate (haematoxylin and eosin, original magnification x100). (b) Higher power view of the surface epithelium from (a) shows increased intraepithelial lymphocytes (haematoxylin and eosin, original magnification x400).
CJGH2016-6091571.001.jpg
PMC4904703_01_CJGH2016-6091571.001.jpg
fig1
Biopsies of the distal duodenum and duodenal cap revealed marked villous blunting with near complete villous atrophy of the small intestinal mucosa in some areas (Figure 1).
Follow-up biopsy 14 weeks after discontinuation of olmesartan shows striking normalization of the duodenal histology. There is normal villous architecture and no increase in intraepithelial lymphocytes in the biopsy (haematoxylin and eosin, original magnification x100).
CJGH2016-6091571.002.jpg
PMC4904703_01_CJGH2016-6091571.002.jpg
fig2
Follow-up endoscopy 14 weeks later demonstrated complete resolution of the duodenal inflammatory changes and restoration of normal villous architecture (Figure 2).