PMC8474250_01
Radiologic assessment of LMs assessed by MRI (red arrow) at baseline and during treatment. MRI, magnetic resonance imaging; CSF, cerebrospinal fluid; LM, leptomeningeal metastasis.
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LM (Fig. 1) without extracranial disease. LM was also confirmed by means of a positive cerebrospinal fluid (CSF) cytology. After two cycles, radiologic tests reported a stable disease, although the CSF analysis before each cycle remained positive (Fig. 1). After 4 cycles, lumbar MRI and CSF analysis revealed a complete radiologic and cytologic response in LM (Fig. 1) with partial response in BM.