PMC5422834_01
a Slit-lamp photograph showing the normal appearance of the iris in the right eye. b Diffuse brown pigmentation of the iris in the left eye is presented. c Gonioscopy of the right eye revealing a normal open angle. d Gonioscopy of the left eye showing an open angle with circumferential heavy pigmentation.
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F1
There was no pigment dispersion of the anterior chamber and no pigment deposition of the cornea (Fig. 1).
a Histological microphotograph showing a densely pigmented mass involving the iris, ciliary body, trabecular meshwork, and Schlemm's canal. Hematoxylin and eosin. 40x. b A bleached preparation revealing large tumor cells with central and paracentral nuclei. The tumor cells show a low nuclear-to-cytoplasmic ratio without mitosis (bleached preparation. Hematoxylin and eosin. 200x). c An ultrastructural microphotograph showing melanin-containing tumor cells (white arrow) and trabecular meshwork cells (black arrow) in the trabecular meshwork. The melanin granules are not phagocytosed by the trabecular cells (electron micrograph, 2,000x).
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F2
Electron microscopy of the trabecular meshwork revealed melanin-bearing tumor cells invading the intertrabecular spaces, and the melanin granules were not phagocytosed in the trabecular cells (Fig. 2).