PMC8801805_01
(Case 2) Color fundus and optical coherence tomography (OCT) examinations. (A) Fundus examinations at the presentation in May 2021(2 months after the vaccination); (B) OCT photos in May 2021 demonstrated the foveal neurosensory detachment in the right eye; (C) OCT photos in July 2021, most of the retinal neurosensory layer in foveola back to the retinal pigment epithelium with the hyperreflective subfoveal lesion.
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F1
The dilated fundus examination (OD/OS) reveals signs of "sunset glow" (Figure 1A). The foveal neurosensory detachment in the right eye was noticed by OCT (Figure 1B). Most of the retinal neurosensory layer in foveola returned back to the retinal pigment epithelium in the right eye (Figure 1C). Slit-lamp examination revealed a dendritic ulcer with terminal bulbs in the central cornea and it becomes readily apparent with fluorescein staining (Supplementary Figure 1A). The cornea ulcer healed with a light nebula left and the BCVA of her left eye returned to 20/100 (Supplementary Figure 1B).
PMC8801805_02
(Case 5) Facial blisters photos. (A) 1 day after receiving the first dose of coronavirus disease 2019 (COVID-19) vaccine; (B) 2 months after the vaccine injection. After receiving an intravenous injection of ganciclovir, the blisters healed gradually with remained scabs on her right forehead (B).
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F2
Patient 5 presented to our clinic in June 2021 with foreign body sensation, lacrimation, and redness in her red-eye, accompanied by groups of fluid-filled blisters on her right forehead 1 day after receiving the first dose of vaccine (Figure 2A). After being given an intravenous injection of ganciclovir and plus with topical application of ganciclovir gel and cyclosporine eyedrop for 2 months, the facial blisters and corneal ulcer in her right eye healed (Figure 2B, Supplementary Figure 2).
(Case 6) Slit-lamp examination photos at the presentation.
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F3
The cornea was clear, and no cells or flares were observed in the anterior chamber (Figure 3).