PMC7714937_01
Timeline of the hospitalisation.
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Figure 1 ). Family members reported similar symptoms.
Complete resolution of the pulmonary infiltrates following recovery. (A) Computerized tomography (CT) 2 months before SARS-SoV-2 infection. (B) CT at hospital admission. (C) CT at hospital discharge. (D) CT at follow-up.
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Alveolar-arterial (Aa)-gradient of 34,4 mm Hg (expected gradient of 13.3 mm Hg). An initial chest CT scan revealed bilateral ground-glass opacities (see  Figure 2 ).
PMC7714937_02
Immune Responses to SARS-CoV-2.
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SARS-CoV-2 spike S1 protein-specific IgG could be detected, decreasing again at 25 weeks (see  Figure 3A ). In parallel, we studied cellular immune responses. SARS-CoV-2-specific cytotoxic lymphocytes were low throughout the time course, which was comparable with the control population. Figure 3B ). Finally, we also tested the innate antiviral response and found a comparable interferon stimulated gene induction upon TLR7 and recombinant interferon-alpha ( Figure 3C ). These results indicated that the immunodeficiency was restricted to an impaired humoral response towards SARS-CoV-2.