PMC2729275_01
Abdominal computed tomography. Computed tomography revealed longest diameter 40 mm-sized hepatic mass in the posterior inferior segment of the liver (a) and small nodules scattered throughout both hepatic lobes (b). After 6 courses administration of amrubicin as a third-line chemotherapy, the mass decreased (c).
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fig1
Computed tomography (CT) scans of the abdomen revealed that the hepatic mass of the longest diameter (40 mm) in size was seen in the posterior inferior segment of the liver and that small nodules were scattered throughout both of the hepatic lobes (Figures 1(a) and 1(b)). CT scans thereafter revealed a reduction of the hepatic mass in the posterior inferior segment, from 27 mm to 15 mm after the second course and further to 9 mm after the sixth course, and the other hepatic and pulmonary nodules were also reduced in size, indicating a partial response (Figure 1(c)).
Immunohistochemical examination of small-cell carcinoma of the liver. (a) Tumor cells display large hyperchromatic nuclei and scanty cytoplasm, H&E. (b) Immunohistochemically, the atypical cells are positive for AE1/AE3, (c) N-CAM and (d) NSE. Magnification ratio: 200 times.
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fig2
Immunohistochemically, the atypical cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and neuroendocrine markers (N-CAM and NSE), but negative for a lymphocytic marker (LCA), which was consistent with the features of a small-cell carcinoma (Figure 2).