PMC6498684_01
Clinical course of the patient. Trough plasma infliximab (IFX, open circle), immunoglobulin G (IgG, closed circle) and C-reactive protein levels (CRP, open triangle) levels are shown. IFX was administered at 5 mg/kg (days 0 and 10), 10 mg/kg (day 23), and thereafter at 8 mg/kg at 2-week intervals. Immunoglobulin (2.5 g) was administered on days 17, 31, 37, 45, 51, 59, 65, 72, 85 and thereafter once a week for at least a few months. Gray circles represent the escalation of CRP on days 87 and 126 due to infections
40780_2019_136_Fig1_HTML.jpg
PMC6498684_01_40780_2019_136_Fig1_HTML.jpg
Fig1
Based on the clinical courses of blood CRP and IFX levels (Fig. 1), trough IFX levels were decreased from 23.6 mug/mL (day 10) to 2.5 mug/mL (day 23). It is noteworthy to mention that a similar pattern -initial decreases followed by increases- was observed in the clinical courses of IFX and IgG (Fig. 1).