PMC4101939_01
Macroscopic view of the enlarged spleen, nodular appearance (arrow).
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fig1
The spleen was 1.200 g in weight and 19 x 15 x 11 cm in size, with nodular appearance and areas of necrosis (Figure 1).
Microscopic view of splenic angiosarcoma (Hematoxylin-Eosin stain, H-E x200). Area of atypical endothelial cells with significant irregular hyperchromatic nuclei (green arrow), area of necrosis (red arrow).
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fig2
The final histopathological diagnosis was angiosarcoma originating from the spleen (Figures 2 and 3).
Microscopic image of the same lesion (H-E x400), disorganized anastomosing vascular channels lined by large, atypical endothelial cells (green arrow).
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fig3
The final histopathological diagnosis was angiosarcoma originating from the spleen (Figures 2 and 3).
Immunohistochemical stain of angiosarcoma of the spleen (CD34 x400).
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fig4
Immunohistochemical staining was positive for vimentin, CD31, CD34 (Figure 4), and factor VIII (Figure 5) and negative for CD68.
Immunohistochemical stain of angiosarcoma of the spleen (factor VIII x400).
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fig5
Immunohistochemical staining was positive for vimentin, CD31, CD34 (Figure 4), and factor VIII (Figure 5) and negative for CD68.