PMC10205416_01
(a) Chest CT scan obtained for case 1, showing diffuse ground glass opacities consistent with COVID-19 pneumonia. (b) Repeat chest CT scan for case 1 5 days later, showing a new right-sided pulmonary infarct, found later to be secondary to mucormycosis angioinvasive fungal infection.
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CT-angiogram (Figure 1(a)) showed diffuse ground glass opacities without pulmonary emboli. A right upper lobe opacity was noted on her chest radiograph and CT (Figure 1(b)) with progressive pneumomediastinum, concerning for lung infarction.
(a) Lung autopsy from case 1 showing diffuse alveolar hemorrhage. (b) Lung autopsy from case 1 showing positive in situ hybridization for COVID-19 within the alveolar macrophages and alveolar epithelium, suggestive for an acute COVID-19 pneumonia/infection. (c) Lung autopsy obtained from case 1, showing fungal (Mucor) elements in the right upper lobe, with the classic branching pattern, confirmed by GMS and tissue culture.
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Autopsy showed diffuse alveolar damage and multiple foci of alveolar hemorrhage (Figures 2(a) and 2(b)). There was a 5 cm infarcted lesion with an angioinvasive fungal infection (Figure 2(c)).
PMC10205416_02
Variable COVID-19-related pathologies in immunocompromised patients: (a) chest CT angiogram demonstrating filling defects in the posterior and basal branches of pulmonary arteries, consistent with pulmonary embolism; (b) AP chest radiograph showing bilateral moderate to large pneumothoraxes.
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Her course was complicated with other morbidities including pneumomediastinum and pneumothorax (Figure 3(b)), requiring peritoneal drain and chest tube placement.
PMC10205416_03
Variable COVID-19-related pathologies in immunocompromised patients: (a) chest CT angiogram demonstrating filling defects in the posterior and basal branches of pulmonary arteries, consistent with pulmonary embolism; (b) AP chest radiograph showing bilateral moderate to large pneumothoraxes.
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Her course was complicated with other morbidities including pneumomediastinum and pneumothorax (Figure 3(b)), requiring peritoneal drain and chest tube placement.
PMC10205416_04