PMC10368102_01
a Widefield fundus photography showed a yellow-white elevated lesion with exudative retinal detachment around the superior vessel in the left eye. b Fundus autofluorescence showed granular and partially hypofluorescent at the protuberant lesion area and hyperfluorescent at the area of exudative retinal detachment. c Optical coherence tomography showed a choroidal mass lesion with a mildly irregular anterior surface (arrow) and subretinal fluid (*). d B-mode ultrasonography revealed a flattened, elevated lesion with medium-to-high reflectivity (arrowhead).
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Fig. 1a). Fundus autofluorescence showed granular and partial hypofluorescence in the protuberant lesion and hyperfluorescence in the area of exudative retinal detachment (shown in Fig. 1b). OCT revealed a choroidal mass lesion with mildly irregular anterior surface-associated subretinal fluid (shown in Fig. 1c). Fig. 1d). Fluorescein angiography showed early spotty and mottled hyperfluorescence in the lesion, late fluorescence leakage from the retinal pigment epithelium, and ring hypofluorescence along the border of the lesion (shown in Fig. 2a, b).
a, b Fluorescein angiography showed early spotty and mottled hyperfluorescence in the left eye lesion area, late fluorescence leakage from the retinal pigment epithelium, and ring hypofluorescence along the border of the lesion (arrow). c, d Indocyanine-green angiography showed a consistent hypofluorescence from the early to late stages in the lesion area. However, the surrounding area gradually became hyperfluorescent and formed a halo in the late stage (arrow).
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Fig. 1d). Fluorescein angiography showed early spotty and mottled hyperfluorescence in the lesion, late fluorescence leakage from the retinal pigment epithelium, and ring hypofluorescence along the border of the lesion (shown in Fig. 2a, b). The central area was consistently hypofluorescent from the early to late stage, but the surrounding area became hyperfluorescent and formed a halo in the late stage (shown in Fig. 2c, d).
a-c A whole-body computed tomography scan revealed a right lower lobe lung tumor, pleural dissemination, pleural effusion, and metastasis to the left iliac bone (arrow).
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A chest radiograph showed an abnormal shadow in the right lower lung lobe, and a whole-body computed tomography scan revealed a right lower lobe lung tumor, pleural dissemination, pleural effusion, and metastasis to the left iliac bone (shown in Fig. 3a-c).
a-d Two months after osimertinib therapy, fundus findings, optical coherence tomography, and B-mode ultrasonography revealed a left choroidal lesion, and subretinal fluid was almost completely gone. e, f The right lower lobe lung cancer had shrunk to about 15 mm in maximum diameter and decreased pleural effusion after 6 months of treatment with osimertinib.
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Fig. 4a-d). Furthermore, after 6 months of treatment with osimertinib, the right lower lobe lung cancer shrank to a maximum diameter of 15 mm, and pleural effusion decreased (shown in Fig. 4e, f).