PMC3362185_01
Clinical presentation of ARGD. a Multiple papules in a plaque on the elbow. b Multiple papules grouped on the thenar region.
cde-0004-0080-g01.jpg
PMC3362185_01_cde-0004-0080-g01.jpg
F1
They corresponded to erythematous and discrete hyperkeratotic papules which had been present for a few weeks (fig. 1a, b).
Immunohistopathology of an ARGD papule. a Perivascular clusters of CD3+ lymphocytes (x200). b Perivascular distribution of MAC387+ macrophages (x200). c Interstitial spread of CD68+ macrophages (x200). d Interstitial presence of factor XIIIa+ DD1 (x200).
cde-0004-0080-g02.jpg
PMC3362185_01_cde-0004-0080-g02.jpg
F2
T lymphocytes predominating in the perivascular area (fig. 2a). The patterns of histiocyte distribution were quite distinct regarding cell differentiation. The MAC387+ cells were rather clustered in the vicinity of vessels (fig. 2b), where they were intermingled with lymphocytes. By contrast, CD68+ cells were interspersed between collagen bundles (fig. 2c). The pattern of DD1 distribution was similar to that of CD68+ histiocytes (fig. 2d).