PMC5110953_01
(A) Pre-treatment colonic images showing multiple strawberry-like hamartomatous colonic polyps. (B) Post-treatment colonic images showing a single tubulovillous adenoma with low-grade dysplasia and resolution of previous hamartomatous polyps.
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F1
A repeat gastroscopy and colonoscopy revealed normalization of mucosal changes (Figures 1 and 2).
(A) Gastric biopsies taken at time of diagnosis. Numerous pieces from various parts of the stomach show similar features. On low (a - H&E, 2x magnification) and medium (b - H&E, 10x magnification) power views, tortuous hyperplastic glands with occasional mild branching and dilatation are identified. A different field (c - H&E, 10x magnification) demonstrates an area of prominent lamina propria edema with a mixed inflammatory cell infiltrate including eosinophils. (B) (a - H&E, 5x magnification) (b - H&E, 2x magnification): biopsies of colonic hamartomatous polyps taken a year after diagnosis. The crypts are tortuous, and some are cystically dilated secondary to inspissated mucin. The intervening lamina propria shows an infiltrate of predominantly mononuclear cells, as well as occasional hypertrophic strands of smooth muscle cells. (B) Shows a focus of low-grade dysplasia arising on the background of a hamartomatous polyp.
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F2
A repeat gastroscopy and colonoscopy revealed normalization of mucosal changes (Figures 1 and 2).