PMC8819180_01
Trend of serum myoglobin and serum creatinine kinase (CK) over time. The light orange boxes denote the periods in which continuous veno-venous hemodiafiltration combined with Cytosorb  was performed.
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F1
Trend of CK and myoglobin over time is depicted in Figure 1. Twelve hours after initiation of CVVHDF plus Cytosorb , CK and myoglobin had substantially decreased (Figure 1), yet, during the subsequent 12 h of extracorporeal treatment an increase of both parameters was noted (Figure 1). After 24 h of CVVHDF plus Cytosorb , extracorporeal treatment was interrupted for 16 h, but because CK and myoglobin continued to increase (Figure 1), a second cycle of CVVHDF plus Cytosorb  was started and continued for another 24 h (Figure 1). Serum creatinine and urea remained in the normal range also after termination of extracorporeal treatment and CK and myoglobin continued to decrease (Figure 1).