PMC6311782_01
Bone marrow: (a, b) Low magnification of the bone marrow aspirate showing myeloid hyperplasia and hypolobated megakaryocytes; (c, d) cytogenetic analysis showed a 46,XY,t(8;22)(p11;q11)[19]/46,XY[1]. Fluorescence in situ hybridization showed the split of one of the two fusion signals indicating a chromosome breakage in the FGFR1 locus; (e) low magnification of the bone marrow biopsy showing hypercellular marrow (hematoxylin and eosin); (f) reticulin stain demonstrating a mild grade of fibrosis.
CRIHEM2018-5724960.001.jpg
PMC6311782_01_CRIHEM2018-5724960.001.jpg
fig1
Fluorescence in situ hybridization (FISH) with LSI FGFR1 (8p11) Dual Color Break Apart (Abbott) showed the split of one of the two fusion signals indicating a chromosome breakage in the FGFR1 locus in 90% of 200 cells analyzed (Figure 1).