PMC10440079_01
MRI Imaging at Second Relapse. Contrast enhanced axial MRI showing infiltrative, multifocal, enhancing mass lesions with one of the larger components centered within the splenium of the corpus callosum.
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MRI of the brain revealed intracerebral, multifocal, enhancing mass lesions with one of the larger components centered within the splenium of the corpus callosum, measuring 1.8 x 3.5 x 1.6 cm (Figure 1).
Pathologic Evaluation of the Left Parietal Tumor. H&E x40 magnification shows large B cells (A). IHC x20 magnification shows that the neoplastic B-cells stained positive for CD20 (B), BCL6 (C), BCL2 (D), MUM1 (E) with a high MIB1 proliferation rate (F).
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An excisional biopsy of the left parietal tumor showed large lymphoma cells (Figure 2A). The lymphoma cells were positive for CD20, BCL6, BCL2, and MUM1 by immunohistochemistry (IHC) (Figure 2B-E). The Ki67 proliferation index was 90% (Figure 2F).
MRI Imaging Post-Treatment. (A and B) MRI after salvage therapy with near complete remission. (C) Repeat contrast enhanced MRI following day 100 work-up status post second ASCT shows complete remission.
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Subsequent MRI demonstrated a near CR (Figure 3A and B).  Her day 100 work-up including a PET scan, MRI brain and bone marrow biopsy showed a CR (Figure 3C).