PMC4982485_01
Interval fundus photography.. Notes: Color fundus photographs at presentation (A), 2 months (B), 3 months (C), and 12 months (D). At month 3, there is no clinical evidence of leukemic infiltration in the right eye (hemorrhages only) with a small residual area remaining just below the foveal center in the left. All lesions and intraretinal hemorrhages in the macula resolved by month 12.
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OU (Figure 1) with larger leukemic lesions temporally in right eye and inferotemporally in the left eye. OCT scans of the macula revealed hyperreflective lesions in the inner retina as well as a separate outer retinal lesion in the right eye (Figure 2). His dilated fundus examinations demonstrated a gradual regression of his leukemic lesions at his 2 and 3 month follow up visits (Figure 1B and Figure 1C respectively). At 12 months from his initial presentation, there was complete resolution of his bilateral foveal infiltration, cotton-wool spots, and retinal hemorrhages (Figure 1D).
Serial spectral domain OCT images, with image registration, through the fovea at presentation (A), 2 months (B), 3 months (C), and 12 months (D).. Notes: (A) Initially, there were large inner foveal hyperreflective lesions in both eyes with a second outer retinal lesion in the right. (B) At 2 months, there were numerous smaller foci in the inner retina present after the larger lesion regressed in both eyes. There was a new area of outer retinal involvement in the left fovea. (C) There is complete resolution of the leukemic infiltrates in the right eye with minimal inner retinal involvement at the fovea in the left. (D) At 12 months, there was complete restoration of the foveal contour with focal residual disruption of the photoreceptor outer segments in each eye.. Abbreviations: CMT, central macular thickness; Mac Vol, macular volume; OCT, optical coherence tomography; OD, oculus dexter; OS, oculus sinister.
imcrj-9-237Fig2.jpg
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OU (Figure 1) with larger leukemic lesions temporally in right eye and inferotemporally in the left eye. OCT scans of the macula revealed hyperreflective lesions in the inner retina as well as a separate outer retinal lesion in the right eye (Figure 2). OCT scans revealed restored foveal contour with focal defects at the photoreceptor outer segments (Figure 2C).