PMC9425504_01
(A) Hodgkin and Reed Sternberg-like cells in a background of small-to medium-sized lymphocytes, H&E stain, 400x; inset shows a RS-like cell with prominent nucleoli, 560x. (B) Background with CD25+ lymphocytes, 125x. (C) CD30+ Hodgkin and Reed-Sternberg-like cells, 400x; in inset a CD20+ cell (800x). (D) CS1-4+ Hodgkin and RS-like cells, 800x.
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Scattered in this background, HRS-like cells were seen, isolated or in small clusters (Fig. 1A). The medium-sized lymphocytes expressed CD3, CD4, CD5, CD25 (Fig. 1B), CD45RO (UCHL-1) and were CD8 negative. The HRS-like cells were positive for CD30 (Fig. 1C), CS1-4 (Fig. 1D), CD79a, and focally for Bcl6 and CD20.