PMC5532512_01
PMC5532512_02
Computer tomography (CT) scans, revealing axillary (upper row), mediastinal (mid row), and abdominal lympadenopathy (lower row) at the three different time points: diagnosis of disseminated infection with Bacillus Calmette-Guerin (0, left column), escalation of antimycobacterial therapy (11, mid column), and diagnosis of Sjogren's syndrome (18, right column). CT scan of right row was performed in the context of a positron emission tomography/CT (see Figure 4).
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F1
We detected a regression of the lymphadenopathy (Figure 1, right column), with diffuse increased uptake of F-18 fluoro-2-deoxyglucose (18FDG) in bone marrow (Figure 3).
(A) Absence of interleukin 12 receptor beta 1 expression on the surface of phytohemagglutinin-stimulated T cells. (B) Further, absence of signal transducer and activator of transcription 4 phosphorylation in interleukin 12 (IL-12)-stimulated T cells.
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F2
Results of flow cytometric analysis of IL12Rbeta1 expression/STAT4 phosphorylation and the rest of immunological investigations are presented in Figure 2 and Table 1, respectively.
PMC5532512_03
Computer tomography (CT) scans, revealing axillary (upper row), mediastinal (mid row), and abdominal lympadenopathy (lower row) at the three different time points: diagnosis of disseminated infection with Bacillus Calmette-Guerin (0, left column), escalation of antimycobacterial therapy (11, mid column), and diagnosis of Sjogren's syndrome (18, right column). CT scan of right row was performed in the context of a positron emission tomography/CT (see Figure 4).
fimmu-08-00885-g001.jpg
PMC5532512_04_fimmu-08-00885-g001.jpg
F1
We detected a regression of the lymphadenopathy (Figure 1, right column), with diffuse increased uptake of F-18 fluoro-2-deoxyglucose (18FDG) in bone marrow (Figure 3).
PMC5532512_04
Computer tomography (CT) scans, revealing axillary (upper row), mediastinal (mid row), and abdominal lympadenopathy (lower row) at the three different time points: diagnosis of disseminated infection with Bacillus Calmette-Guerin (0, left column), escalation of antimycobacterial therapy (11, mid column), and diagnosis of Sjogren's syndrome (18, right column). CT scan of right row was performed in the context of a positron emission tomography/CT (see Figure 4).
fimmu-08-00885-g001.jpg
PMC5532512_04_fimmu-08-00885-g001.jpg
F1
We detected a regression of the lymphadenopathy (Figure 1, right column), with diffuse increased uptake of F-18 fluoro-2-deoxyglucose (18FDG) in bone marrow (Figure 3).
Positron emission tomography/computer tomography scan after completion of an 18-month antimycobacterial therapy, including a 6-month 6-drug regimen, revealing significant homogenous hypermetabolism in the area of the right lacrimal gland (marked with an arrow).
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F3
We detected a regression of the lymphadenopathy (Figure 1, right column), with diffuse increased uptake of F-18 fluoro-2-deoxyglucose (18FDG) in bone marrow (Figure 3).
Histological findings of Sjogren's syndrome in an interleukin 12 receptor beta 1-deficient male. Right panel: lymphocytic infiltrates with periductal distribution in a lacrimal gland biopsy section, stained with hematoxylin and eosin (10x magnification, bar size: 0.5 microg) Left panel: focal lymphocytic infiltration in a minor salivary gland biopsy section, stained with hematoxylin and eosin (10x magnification, bar size: 0.5 microg).
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F4
Schirmer's test. Suspecting a SS, we also performed a labial salivary gland biopsy, which revealed a focal lymphocytic sialadenitis of grade 3 according to the Chisholm-Mason classification (Figure 4).
PMC5532512_05
Histological findings of Sjogren's syndrome in an interleukin 12 receptor beta 1-deficient male. Right panel: lymphocytic infiltrates with periductal distribution in a lacrimal gland biopsy section, stained with hematoxylin and eosin (10x magnification, bar size: 0.5 microg) Left panel: focal lymphocytic infiltration in a minor salivary gland biopsy section, stained with hematoxylin and eosin (10x magnification, bar size: 0.5 microg).
fimmu-08-00885-g004.jpg
PMC5532512_05_fimmu-08-00885-g004.jpg
F4
Schirmer's test. Suspecting a SS, we also performed a labial salivary gland biopsy, which revealed a focal lymphocytic sialadenitis of grade 3 according to the Chisholm-Mason classification (Figure 4).