PMC9508993_01
A female patient with pyoderma gangrenosum, plaque psoriasis and palmoplantar pustulosis who is treated with adalimumab. Lesions of (Ai-Aiii) pyoderma gangrenosum, (Bi-Biii) plaque psoriasis and (Ci) palmoplantar pustulosis were significantly improved (Aiv-Avi, Biv-Bvi and Cii) after 3 months by treating with adalimumab.
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A 68-year-old female attended to our outpatient clinic with a 2-month history of persistent, rapidly developing and aching ulcers affecting her feet (Figure 1Ai-Aiii) and 1-year history of plaque psoriatic lesions symmetrically distributed on the lower extremities (Figure 1Bi-Biii). Pustules were found on her palms (Figure 1Ci). In the third month, the lesions of PG (Figure 1Aiv-Avi), psoriasis (Figure 1Biv-Bvi) and PPP (Figure 1Cii) improved markedly.
Histopathology of the ulcer near the right medial malleolus. (40x) H & E stain showing dense neutrophilic infiltrate in the dermis.
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Histopathology of the ulcer near the right medial malleolus showed dense neutrophils which confined to the dermis (Figure 2), with no indication of cutaneous vasculitis, mycobacterium tuberculosis, parasitic infections or fungal infections.