PMC3907403_01
Bone marrow biopsy intertrabecular space showing bizarre multinucleated cells with hyperchromatic nuclei embedded in bed of necrosis and haemorrhage (200x) H&E.
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figure1
However, a bone marrow examination was conducted prior to this and revealed erythroid hyperplasia, while a bone marrow biopsy showed extensive necrosis, bizarre cells, multinucleated cells, abnormal mitosis, and haemorrhage with normal haematopoietic areas interspersed in between (Figures 1 and 2).
Tumour tissue showing predominantly polygonal cells with moderate to abundant clear cytoplasm, nucleus with high N/C ratio and coarse chromatin and prominent nucleoli (400x) H&E.
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figure2
However, a bone marrow examination was conducted prior to this and revealed erythroid hyperplasia, while a bone marrow biopsy showed extensive necrosis, bizarre cells, multinucleated cells, abnormal mitosis, and haemorrhage with normal haematopoietic areas interspersed in between (Figures 1 and 2).
Tumour cells showing positive staining for betaHCG on IHC (400x).
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On Immunohistochemistry (IHC) tumour cells were positive for betaHCG (Figure 3) while negative for CD31 and CK.