PMC3750510_01
Bone marrow biopsy. Infiltrate of mature lymphoid cells (hematoxylin & eosin, H/E), which stained for CD20 (B cell marker), DBA44 and V600E BRAF (HCL markers). Histology and immunohistology were performed according to standard diagnostic procedures.
2162-3619-2-22-1.jpg
PMC3750510_01_2162-3619-2-22-1.jpg
F1
A contralateral biopsy showed a pattern of marrow infiltration by mature B lymphocytes that was diagnostic of HCL (Figure  1).
Sequential hemochrome and creatinine values in relationship to treatment.
2162-3619-2-22-2.jpg
PMC3750510_01_2162-3619-2-22-2.jpg
F2
Currently, one year after stopping treatment, the patient is in continuous complete hematological remission with stable renal function (Figure  2).