PMC4857692_01
Palmar surface of right hand showing classical target lesions with central vesicle surrounded with erythema and ring of pallor
IJSTD-37-85-g001.jpg
PMC4857692_01_IJSTD-37-85-g001.jpg
F1
A 45 year old male presented with painful raised erythematous papules with central vesicle surrounding area of pallor and edema classically described as target lesions over hands, feet, and extensor aspect of forearms and legs without any involvement of mucous membranes [Figure 1].
Subepidermal vesicle with vacuolization of basal layer, with scattered apoptotic keratinocytes, dermis shows predominantly mononuclear infiltrate with scattered eosinophils at dermoepidermal junction (x40 view)
IJSTD-37-85-g002.jpg
PMC4857692_01_IJSTD-37-85-g002.jpg
F2
Dermis shows predominantly mononuclear with scattered eosinophilic inflammation at dermoepidermal junction with moderate inflammation in perivascular region [Figure 2].