PMC3590018_01
Growth chart showing height and weight of the patient from age 8 to age 13 years. Height and weight are shown as filled black circles, and bone ages as open triangles. Treatment with leptin was initiated at age 10 years 4 months. Treatment was discontinued at age 12 years and then restarted at age 12 years 9 months.
nihms443062f1.jpg
PMC3590018_01_nihms443062f1.jpg
F1
Her bone age was 20 months advanced compared to her chronological age (Figure 1, growth chart).