PMC7605615_01
MRI of the patient with intracranial SFT/HPC. (A) MRI scan revealing tumors uneven enhancement, with large zones of edema around the tumors. (B and C) Postoperative residual tumor (B) with a significantly reduced signal after 2 months of radiotherapy (C).
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The T1- and T2-weighted images of the tumor were isointense, with large zones of edema surrounding the tumor; additionally, the tumor showed uneven enhancement (Figure 1A). The residual tumor after the operation (Figure 1B) was treated with intensity-modulated radiation therapy (64 Gy, 32 times). Craniocerebral MRI performed 2 months later showed that the tumor was significantly smaller than before the operation (Figure 1C).
Hematoxylin and eosin staining of the SFT/HPC specimen. (A) An abundance of blood vessels was observed in tumor tissue, with an typical "staghorn" vascularization and a large number of fusiform tumor cells arranged in bundles between blood vessels. Magnification: 100x; scale bar: 100 mum. (B) Mitotic bodies were clearly visible (black arrow; >=5 mitoses per 10 high-power fields). Magnification: 400x; scale bar: 100 mum.
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The extracellular matrix was composed of bright eosinophilic collagen bands (Figure 2A and B), and the Ki-67 labeling index reached 20% in local hot spots.
Immunohistochemical analysis of the SFT/HPC specimen. (A-C) with immunopositivity for CD34 (A), STAT6 (B), and BCL-2 (C). Magnification: 400x; scale bar: 100 mum.
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Immunohistochemical analysis revealed positivity for cluster of differentiation (CD)34 (Figure 3A), CD99, signal transducer and activator of transcription (STAT)6 (Figure 3B), and B cell lymphoma (BCL)-2 (Figure 3C); and negative staining for smooth muscle actin and desmin.