PMC4629305_01
14-month-old female child with spinal cord ganglioglioma. Sagittal T1 fat-suppressed gadolinium contrast-enhanced MR image of the cervical and thoracic spine shows a long segment enhancing intramedullary lesion (arrows) extending from T1 to T11 with cord expansion and syringomyelia (arrowheads) at the rostral and caudal aspects of the enhancing tumor.
JCIS-5-53-g002.jpg
PMC4629305_01_JCIS-5-53-g002.jpg
F1
T1 to T11 levels with corresponding cord expansion, heterogeneous enhancement following gadolinium administration [Figure 1], isointense T1 signal, and heterogeneously hyperintense T2 signal [Figure 2]. There was associated syringomyelia at the rostral and caudal aspects of the enhancing tumor.
14-month-old female child with spinal cord ganglioglioma. Sagittal T2-weighted MR image of the cervical and thoracic spine shows syringomyelia (arrows) rostral to the intramedullary tumor (star). Abnormal hyperintense T2 signal and expansion is noted in the upper cervical spinal cord and brainstem (arrowheads).
JCIS-5-53-g003.jpg
PMC4629305_01_JCIS-5-53-g003.jpg
F2
T1 to T11 levels with corresponding cord expansion, heterogeneous enhancement following gadolinium administration [Figure 1], isointense T1 signal, and heterogeneously hyperintense T2 signal [Figure 2]. There was associated syringomyelia at the rostral and caudal aspects of the enhancing tumor.
14-month-old female child with spinal cord ganglioglioma. Hematoxylin and eosin stained (x200).surgical resection specimen shows the tumor consisting of numerous dysplastic and binucleate ganglion cells in clusters (arrows).
JCIS-5-53-g004.jpg
PMC4629305_01_JCIS-5-53-g004.jpg
F3
Sections from the surgical excision revealed diffuse glial fibrillary acidic protein (GFAP)-immunoreactive glioma with collections of atypical, variably binucleate synaptophysin-immunoreactive cells with no Neu-N or neurofilament immunoreactivity [Figures 3-5].
14-month-old female child with spinal cord ganglioglioma. Immunohistochemistry performed on the surgical resection specimen shows fibrillary GFAP-immunoreactive astrocytes (brown) spanning the tumor stroma (anti-GFAP immunohistochemical staining done with diaminobenzidine chromagen and hematoxylin counterstain; original magnification x200).
JCIS-5-53-g005.jpg
PMC4629305_01_JCIS-5-53-g005.jpg
F4
Sections from the surgical excision revealed diffuse glial fibrillary acidic protein (GFAP)-immunoreactive glioma with collections of atypical, variably binucleate synaptophysin-immunoreactive cells with no Neu-N or neurofilament immunoreactivity [Figures 3-5].
14-month-old female child with spinal cord ganglioglioma. Immunohistochemistry performed on the surgical resection specimen shows dysplastic and binucleate ganglion cells with extensive synaptophysin immunoreactivity in somas and processes (brown) (anti-synaptophysin immunohistochemical staining done with diaminobenzidine chromagen and hematoxylin counterstain; original magnification x200).
JCIS-5-53-g006.jpg
PMC4629305_01_JCIS-5-53-g006.jpg
F5
Sections from the surgical excision revealed diffuse glial fibrillary acidic protein (GFAP)-immunoreactive glioma with collections of atypical, variably binucleate synaptophysin-immunoreactive cells with no Neu-N or neurofilament immunoreactivity [Figures 3-5].