PMC10159318_01
Multiplanar and multisequential magnetic resonance imaging of the brain (a) T2WI hyperintense lesion with peripheral hemosiderin ring. (b)T1 without and with (c) contrast showed patchy enhancement on the lateral aspect. (d1) Fluid-attenuated inversion recovery (FLAIR) image surrounding edema noted at the medial aspect of the lesion. (d2) FLAIR image with punctate hyper-intensities in the left cortical region. (e) Susceptibility-weighted imaging lesion had diffuse signals drop-out (f and g). Diffusion-weighted imaging and apparent diffusion coefficient sequences showing diffusion restriction.
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F1
On MRI [Figure 1], abnormal signal intensity was noted on the left medial frontal region, predominantly hyperintense on T2/fluid-attenuated inversion recovery (FLAIR), and showed diffusion restriction on diffusion-weighted imaging sequence.
Histopathology of glioblastoma multiforme. (a) H&E staining showed neoplastic cells with hyperchromatic nuclei and inconspicuous nucleoli with moderate amounts of eosinophilic cytoplasm. Multiple gemistocytes and areas of palisading tumor necrosis are also seen in the background. (b) Isocitrate dehydrogenase immunohistochemical staining negative for IDH mutation.
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F2
The patient was thus diagnosed with glioblastoma, IDH-1 wild type [Figure 2].