PMC3708632_01
Discrete, violaceous lesions of Kaposi's sarcoma on the arm and thigh.
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Physical examination revealed multiple small, discrete, violaceous patches, plaques and nodules distributed bilaterally over the lower and upper extremities with scattered lesions over the shoulder and buttocks (Figures 1, 2, 3).
Lesions of Kaposi's sarcoma on the lower limb, showing confluence.
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Physical examination revealed multiple small, discrete, violaceous patches, plaques and nodules distributed bilaterally over the lower and upper extremities with scattered lesions over the shoulder and buttocks (Figures 1, 2, 3). Some of the small papules and nodules had coalesced to form large plaques (Figure 2).
Violaceous nodules and plaques of Kaposi's sarcoma. Note also edema of the hand.
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Physical examination revealed multiple small, discrete, violaceous patches, plaques and nodules distributed bilaterally over the lower and upper extremities with scattered lesions over the shoulder and buttocks (Figures 1, 2, 3). Lymphedema was noted in the lower extremities and hands (Figure 3).
Characteristic patches of Kaposi's sarcoma on the hard and soft palate.
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Mucous membrane of the oral cavity showed characteristic patches on the hard and soft palate (Figure 4).
Micro-section from plaque shows dilated, irregular new vessels and pre-existing vessels in the dermis. Also seen are few scattered spindle cells (H & Ex 400).
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Histopathologic examination of skin biopsy from one of the patches (Figure 5) showed neovascularization of the entire dermis with small irregular vascular channels intercommunicating and surrounding preexisting normal vascular channels.
Micro-section from nodule shows fascicles of spindle cells in the dermis and superficial subcutis. Between the spindle cells are seen red blood cells in pseudo vascular channels. Spindle cells are seen encircling adipocytes and nerve fascicles (H & Ex400).
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Section from a nodule (Figure 6) showed fascicles of spindle cells with interweaving free red cells.
Immunohistochemistry. The section which is immune-stained for CD31 highlights tumor cells in the vessels and in the stroma.
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On immunohistochemistry, the tumor cells were positive for CD31 (Figure 7) and CD34.