PMC3307457_01
(a) Moderately cellular cytosmear showing clusters of cells with histioid appearance, lymphoid cells and few bare nuclei (MGG, x100); (b) Cytological smear with loose clusters of oval to polygonal cells having basophilic granular cytoplasm (MGG, x200)
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PMC3307457_01_JCytol-29-60-g001.jpg
F1
Cytosmears examined were moderately cellular with dual cell population, composed predominantly of oval to polygonal cells with abundant cytoplasm and round bland nuclei resembling histiocytes [Figure 1]. The background showed few discrete round cells with round nuclei and scanty cytoplasm suggestive of mature lymphocytes [Figure 1].
Section show diffusely arranged tumor cells with granular eosinophilic cytoplasm intervening adnexal structures and presence of lymphoid aggregate (H and E, x100); Inset show tumor cells showing cytoplasmic and nuclear immunopositivity for S100 protein (IHC, x100)
JCytol-29-60-g002.jpg
PMC3307457_01_JCytol-29-60-g002.jpg
F2
Individual cells appeared round to oval with abundant granular eosinophilic cytoplasm and centrally placed bland nuclei [Figure 2]. Focal collections of lymphocytes were also seen [Figure 2]. Immunohistochemistry showed S100 positivity in nucleus and cytoplasm ([Figure 2] inset).