PMC6465706_01
a Clinical appearance. Indurated purpuric plaque with several purpuric papules ( ) surrounding the postoperative scar on the left breast. b A few days after the cessation of anastrozole, the purpura has disappeared.
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F1
Additionally, several purpuric papules developed in the purpura (Fig. 1a); thus, another skin biopsy that included the new papule was performed. A few days after the cessation of anastrozole, the purpura rapidly disappeared (Fig. 1b).
Histological findings reveal proliferation and expansion of the capillary vessels with hemorrhage in the superficial dermis (arrows indicate the area with significant change). There is no evidence of skin metastasis of the breast cancer. Hematoxylin and eosin stain, magnification: x40 (a), x100 (b), x200 (c).
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F2
Histological findings of the second biopsy specimens showed the proliferation and expansion of capillary vessels with hemorrhage in the superficial dermis (Fig. 2a-c).