PMC6381883_01
In the surgical specimen, there were irregular nests of polygonal cells with heteromorphic nuclei. Some tumor cells had foamy cytoplasm, and sebaceous differentiation was observed (hematoxylin-eosin x20).
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F1
Given postoperative pathological findings of nests of polygonal tumor cells with highly heteromorphic nuclei and foamy lipid droplets, a final diagnosis of SC was made (Fig. 1).
a: Chest computed tomography images show multiple lung metastases. b: After two cycles of chemotherapy with carboplatin and paclitaxel, all lung metastatic nodules regressed.
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F2
Four months after surgery, multiple lung metastases (Fig. 2a) and abdominal subcutaneous metastases occurred. After the second cycle of chemotherapy, computed tomography (CT) for response assessment revealed a partial response (PR) with an at least 50% reduction in total maximum diameter of lung (Fig. 2b) and subcutaneous metastatic nodules.