PMC5821964_01
Lymph node biopsy shows small- to medium-sized atypical lymphocytes (a). In this infiltrate, immunohistochemistry is positive for CD3 (b) and in situ hybridization is positive for Epstein-Barr virus (c). Bone marrow biopsy shows clusters of atypical lymphocytes (d) and histiocytes with hemophagocytosis (e). Immunohistochemical staining for CD3 is positive (f).
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fig1
In situ hybridization for Epstein-Barr virus (EBV) was positive on atypical lymphoid cells coexpressing CD4 and CD8 (Figure 1). Immunohistochemical stains showed that these cells were positive for CD3, CD5, CD7, and both CD4 and CD8 (Figure 1).