PMC5443337_01
Clinical progression of index case and family pedigree.. 
A. Clinical progression of index case over time with serum albumin (solid line), urine protein/creatinine ratio (dashed line) and estimated Glomerular Filtration Rate (eGFR). Pregnancies marked with shaded area (P).
B. Family tree with index case arrowed. Males are squares, females are circles. Heterozygously affected individuals are semi-shaded. Sibling with proteinuria marked with "?".
f1000research-6-12212-g0000.jpg
PMC5443337_02_f1000research-6-12212-g0000.jpg
f1
More recently, the index case's brother was identified as having heavy proteinuria in 2016 at age 40, and is undergoing further investigations ( Figure 1B).
PMC5443337_02
Clinical progression of index case and family pedigree.. 
A. Clinical progression of index case over time with serum albumin (solid line), urine protein/creatinine ratio (dashed line) and estimated Glomerular Filtration Rate (eGFR). Pregnancies marked with shaded area (P).
B. Family tree with index case arrowed. Males are squares, females are circles. Heterozygously affected individuals are semi-shaded. Sibling with proteinuria marked with "?".
f1000research-6-12212-g0000.jpg
PMC5443337_02_f1000research-6-12212-g0000.jpg
f1
More recently, the index case's brother was identified as having heavy proteinuria in 2016 at age 40, and is undergoing further investigations ( Figure 1B).