PMC3792542_01
Granules of stainable iron (haemosiderin) within cytoplasm of epithelium of minor glands of the mucosa of the lower lip. Perls' technique with nuclear fast red counterstain, original magnification 1,000x.
CDI2013-642643.001.jpg
PMC3792542_01_CDI2013-642643.001.jpg
fig1
The diagnosis of NH was confirmed at 12 days of age by microscopy of a lower lip mucosa biopsy specimen, which found haemosiderin granules within submucosal acinar gland cells (Figure 1).
Hepatectomy specimen, postnatal age 30 days. Nodularity is apparent. The relatively stroma-poor nodules consisted of hepatocellular parenchyma, sometimes cholestatic. The intervening regions that exhibit more compact connective-tissue elements were sites of hepatocellular loss and stromal collapse, with neocholangiolar transformation of remaining parenchyma. Reticulin, original magnification 40x.
CDI2013-642643.002.jpg
PMC3792542_01_CDI2013-642643.002.jpg
fig2
Examination of the explanted liver found postnecrotic cirrhosis with canalicular and hepatocellular cholestasis (Figure 2).