PMC6465719_01
Immunofluorescence shows 2+ linear stating along the glomerular basement membrane with antibodies against IgG (a) and kappa (b). All other stains including lambda (c) and albumin (d) were negative. IgG1 subclass shows 2+ linear staining of glomerular basement membrane (e). Staining for IgG subclasses IgG2, IgG3, and IgG4 was negative (not shown).
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F1
Kidney biopsy revealed linear staining along the GBMs by monotypic IgG1-kappa (Fig. 1) with numerous red blood cell casts (Fig. 2), interstitial fibrosis, tubular atrophy, moderate arteriosclerosis, and moderate arteriolar hyalinosis of moderate chronicity.
Electron microscopic examination of glomerulus reveals widespread effacement of the foot processes (black arrows) and absence of any immune complex electron dense deposits.
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F3
Electron microscopic examination of the glomerulus (Fig. 3) revealed widespread effacement of the foot processes and absence of any immune complex electron dense deposits.