PMC9860130_01
(A) Pathologic findings in a colonic biopsy sample. Sheets of eosinophils within the lamina propria extending into the muscularis mucosa were observed with a diagnosis of eosinophilic colitis (H&E x100, x200, x400). (B) Clinical progression. The violet arrow indicates the point at which steroid intake was discontinued. The green arrow indicates the point of PEC remission. The blue arrow indicates the point of CSU remission. CSU, chronic spontaneous urticaria; PEC, primary eosinophilic colitis
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In the biopsy sample obtained by colonoscopy, mild chronic inflammation with scattered eosinophils (up to 20/high power field (HPF) in the ascending and descending biopsy samples, up to 10/HPF in the transverse colon sample and up to 25/HPF in the sigmoid colon sample) was observed (Figure 1A). IHC therapy (Figure 1B). In the first week after the discontinuation of steroids and the initiation of IHC therapy, her abdominal cramping pain appeared every day, but it was well-controlled by the intake of the second-generation H1 antihistamine levocetirizine (5 mg) within 30 minutes after the manifestation of pain.