PMC4435372_01
Liver biopsies, all H&E stains, except where indicated. Original magnification is shown for each photomicrograph. (A) Lobular collapse due to hepatocyte loss. (B) Relatively thin bundles of recent periportal and sinusoidal fibrosis along with some bands of darker staining, more mature bridging fibrosis. Moderate ductular proliferation is seen but ductular bile is absent. (C) Lack of inflammation in areas of injured hepatocytes. (D) Neutrophils associated with proliferating ductules seen in areas of fibrosis. (E) The injured hepatocytes show abundant Mallory hyaline (arrows) and ballooning degeneration (arrowheads). (F) Prussian blue (iron) stain is negative for increased hemosiderin deposition but highlights occasional canalicular bile plugs (arrowhead) and lipofuschin pigment in hepatocytes (arrows).
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F1
Notably, there was a near complete absence of an inflammatory response except for the neutrophils associated with proliferating ductules seen in the fibrotic portal areas (Figure 1).