PMC6327696_01
T2 fluid-attenuated inversion recovery magnetic resonance imaging brain axial image shows no signal changes in bilateral medial temporal lobes
AIAN-22-121-g001.jpg
PMC6327696_01_AIAN-22-121-g001.jpg
F1
He had hyponatremia (serum sodium 120 mg/dl), cerebrospinal fluid analysis was normal, magnetic resonance imaging (MRI) of the brain T2-weighted images [Figure 1] showed diffuse cerebral atrophy with multifocal nonspecific white matter signal changes and no signal changes were observed in bilateral medial temporal lobes in T2 fluid-attenuated inversion recovery images [Figure 2]; electroencephalography showed diffuse background slowing, LGI-1 antibody was strongly positive, contactin associated protein (CASPR) 2 was negative, glutamate receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) 1 and 2 were negative, glutamate receptor N-methyl-D-aspartate was negative, and gamma-aminobutyric acid B1 and B2 receptors were negative.
T2-weighted magnetic resonance imaging image shows diffuse cerebral atrophy with multiple nonspecific white matter signal changes
AIAN-22-121-g002.jpg
PMC6327696_01_AIAN-22-121-g002.jpg
F2
He had hyponatremia (serum sodium 120 mg/dl), cerebrospinal fluid analysis was normal, magnetic resonance imaging (MRI) of the brain T2-weighted images [Figure 1] showed diffuse cerebral atrophy with multifocal nonspecific white matter signal changes and no signal changes were observed in bilateral medial temporal lobes in T2 fluid-attenuated inversion recovery images [Figure 2]; electroencephalography showed diffuse background slowing, LGI-1 antibody was strongly positive, contactin associated protein (CASPR) 2 was negative, glutamate receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) 1 and 2 were negative, glutamate receptor N-methyl-D-aspartate was negative, and gamma-aminobutyric acid B1 and B2 receptors were negative.