PMC5137173_01
Enhancing, lipid-poor mass with coarse areas of calcification measuring 7.0 x 6.7 cm in the right adrenal gland. Note relationship of the mass to the vena cava.
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To better characterize the mass, a computerized tomography (CT) scan was performed, which demonstrated a 7 cm enhancing, lipid-poor adrenal mass with coarse areas of calcification concerning for a primary adrenal cortical carcinoma (Fig. 1).
(A) Angiosarcoma of the adrenal gland. High power magnification demonstrates a sheet of large pleomorphic, round epithelioid cells with eosinophilic cytoplasm and large hyperchromatic nuclei with prominent nucleoli. Scattered intracytoplasmic lumina contain erythrocytes. Numerous mitotic figures are present (H & E, 40x magnification). (B) CD31 immunohistochemical stain. Diffuse intense membranous and cytoplasmic tumor cell staining with this vascular marker is apparent. (40x magnification).
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A103, AE1/AE3, CD5, and inhibin (Fig. 2). As such, these findings were consistent with angiosarcoma.