PMC7750334_01
(a) Lung USG of the male patient before stem cell treatment (lung ultrasonography reveals prominent B lines, pleural line is not regular, there are consolidation areas involving air bronchogram, A lines, which are observed in normal lung tissue, are absent). (b) Lung USG of the female patient before stem cell treatment (lung ultrasonography shows irregularities in lung parenchyma and pleural line. Widespread B lines and consolidation areas involving air bronchogram are present. A lines, which are observed in normal lung tissue, are absent). (c) Lung USG of the female patient 15 days after stem cell treatment (irregularities in lung parenchyma and pleural line persist on lung ultrasonography. There is a reduction in the number of B lines and the appearance of A lines is increased. However, the clinical findings of this patient had a more severe course in accordance with the ultrasonographic imaging compared with her brother). (d) Lung USG of the male patient 15 days after MSCs treatment (lung ultrasonography revealed that the number of B lines was reduced, the 'lung sliding' sign developed, A lines appeared, comet tail was observed in the area of imaging, and consolidation areas were deleted)
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F1
USG repeated twelve hours after stem cell treatment (Fig. 1a, Fig. 1b). Ultrasound examination of the lung performed in the female patient three days after treatment and revealed pulmonary consolidation, partial resolution in divided areas, atelectatic regions, and also, it was observed that pleural line abnormalities persisted. It was observed that AIS areas were completely replaced by B lines, A lines became more prominent, and air bronchograms were present in pulmonary consolidation areas in the female patient (Fig. 1c). The male patient's lung ultrasonographic findings were almost normal (Fig. 1d), his oxygen need was reduced and he was receiving free oxygen only during feeding.