PMC5303587_01
Abdominal CT showing irregular tissue mass in the gallbladder fundus (arrow).
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Computed tomography (CT) demonstrated gallbladder wall thickening and pericholecystic fluid suggestive of acute cholecystitis (Figure 1).
Right upper quadrant ultrasound showing 3.8 x 2.4 x 3.5 heterogeneous mass with small calcification emanating from the gallbladder fundus.
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Transabdominal U/S showed a 3.8 x 2.4 x 3.5 cm heterogeneous lesion emanating from the gallbladder fundus, suspicious for malignancy (Figure 2).
Gross examination reveals diffuse gallbladder wall thickening from the tumor mass encompassing the entire gallbladder lumen.
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The tumor appeared to have diffuse growth encompassing the entire gallbladder lumen (Figure 3).
Microscopic examination of gallbladder shows infiltrating carcinoma (a). Tumor is composed of squamous cells with individual cell keratinization (white arrow) and intercellular bridges (black arrows) (b).
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Prominent keratin pearls and intercellular bridges were evident in histology, which are characteristic of squamous cell differentiation (Figure 4).
Local invasion of the tumor in liver parenchyma (black arrows) (a) and duodenum (white arrows) (b).
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Direct infiltration of the hepatic parenchyma and duodenum was noted (Figure 5).