PMC8322771_01
Patient 2 from 
Table 1
. Extensive mixed, mostly macrocystic cervicofacial lymphatic malformations requiring intubation at birth. (A) Baseline after sclerotherapy, prior to initiation of sirolimus. (B) Five months on sirolimus. Sirolimus initiated at 5 months of age. T2 magnetic resonance imaging upon (C) initiation of sirolimus and (D) response after 5 months. T2, transverse relaxation.
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f1
An example of a significant sirolimus response in a young child with significant cervicofacial LMs is shown in  Figure 1 .
Two-month-old female (patient 4 in 
Table 1
) with extensive bilateral microcystic cervicofacial lymphatic malformations with tongue and floor of mouth involvement at (A) start of therapy, and (B) at 6 months. This patient also has extensive bilateral submandibular and facial involvement, which also significant regression during sirolimus therapy (not shown).
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One patient had respiratory tract obstruction with mixed LM after numerous sclerotherapy procedures; the obstructive dyspnea improved with regression of the lesion in the first month without tracheostomy ( Figure 2 ).