PMC8071878_01
KHE in Patient 2: pathological biopsy of the mediastinal mass, which was located in the deep muscular layer of the left cervical root. (A. HE x 200; B. CD31 x 200).
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F1
The vascular tumors were observed in the fibrous tissue and trabecular bone; they were arranged in a lobulated or nested manner, and the cells in some regions were fusiform (Figure 1A). Immunohistochemical staining showed positivity for CD31 (Figure 1B), CD34, and D2-40 but not for Glut-1 and HHV-8.
KHE in Patient 2: X-ray showed slight scoliosis (A), and the angle of the scoliosis was reduced after 3 years of treatment and follow-up (B). Three hours after 99 mTc-MDP 10 mCi was injected intravenously, a whole-body bone scan was performed. It also showed scoliosis and slightly increased radioactive distribution on the right edge of the T12-L2 vertebral body (C).
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F2
Patient 2 was admitted to the hospital due to scoliosis (Figure 2).
KHE in Patient 3: On MRI, a soft tissue mass in the left root of the neck can be seen before treatment (A). After 6 months (B) and 1 year (C) of sirolimus treatment, the size of the lesion was gradually reduced.
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F3
The body and accessory of the junction between the cervical and thoracic vertebrae, T1 and T6, showed bone destruction (Figure 3).
KHE in Patient 6: The MRI showed that large mixed signal mass involved the left lumbar and back, and T7-L4 vertebrae and paraspinal tissue from coronal (A) and sagittal position (B), and we can see that the skin on the left waist and back was involved (C).
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F4
T7-L4 vertebrae and paraspinal tissue were involved in patient 6 (Figure 4). The focus was not clearly separated from the adjacent thoracolumbar vertebrae and dorsal muscles, accompanied by bone destruction of thoracolumbar vertebrae, spinal and left thoracic compression with scoliosis deformities.