PMC3276072_01
Secretory carcinoma shows microcystic pattern and intraluminal secretion, (a) (H&E) and (b) (PAS).
IJBC2011-704657.001.jpg
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fig1
Microscopic examination revealed the classical features of secretory carcinoma with a microcystic pattern (Figure 1(a)) with abundant intra and extracellular PAS-positive secretory material (Figure 1(b)).
The tumor cells show positive nuclear and cytoplasmic staining by S100 antibody (a) positive cytoplasmic staining by EMA antibody, (b) positive cytoplasmic staining by pan cytokeratin, (c) and some showed positive nuclear staining by ER antibody (d).
IJBC2011-704657.002.jpg
PMC3276072_01_IJBC2011-704657.002.jpg
fig2
On immunohistochemistry, the tumor cells were positive for EMA and S-100 protein and focally positive for cytokeratine and ER (Figures 2(a), 2(b), 2(c), and 2(d)) but negative for progesterone receptor, CD34, and CEA (Dako, Carpinteria, CA, USA).