PMC5061599_01
A- Family pedigree showing the segregation of central precocious puberty (CPP) with the paternally inherited MKRN3 p.Pro161Argfs*16 mutation. B- Chromatograms showing the presence of the MKRN3 p.Pro161Argfs*16 mutation in the asymptomatic father (I.1) and in his two daughters who developed CPP (II.1 and II.2). C- Girl's stature-for-age growth chart (CDC) showing the increased growth in the reported girl (II.2) with CPP caused by the MKRN3 p.Pro161Argfs*16 mutation. D- Rapid breast development (Tanner B3) in a 6.7 year-old-girl (II.2) with CPP caused by the MKRN3 p.Pro161Argfs*16 mutation (the exhibition of this photography was authorized by patient's parents). TH: target height.
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F1
She was found to harbor the same mutation, which was inherited from their asymptomatic father (Figures 1A and 1B). Notably, four months later, at the age of 6.7 years, she presented with a height of 124 cm (above the familial range; Figure 1C), with a growth velocity of 12 cm/year, and Tanner stage 3 for breast development (Figure 1D) and stage 1 for pubic hair.