PMC4743274_01
(a) T1-weighted magnetic resonance image showing iso- to hypo-intense lesion in the right cerebellopontine angle region extending into the right temporal lobe. (b) The lesion showing homogeneous enhancement on T1-weighted postcontrast image. (c) T2-weighted image showing grossly hypointense signal with areas of hyperintensity
SNI-7-7-g001.jpg
PMC4743274_01_SNI-7-7-g001.jpg
F1
This progression in size and extension of the tumor had occurred in the span of just 2 months [Figure 1].
(a) Sheets of undifferentiated primitive appearing round cells (H and E, x400). (b) Negative in tumor cells (inset; positive external control on the same slide) (GFAP immunostain, x100). (c) A very high proliferative index (MiB-1 immunostain, x200 magnification)
SNI-7-7-g002.jpg
PMC4743274_01_SNI-7-7-g002.jpg
F2
T (CD3), Tdt, cytokeratin AE1/AE3, CD56, and synaptophysin tested negative. These findings confirmed a diagnosis of PNET [Figure 2].