PMC8564479_01
Description of prognostic risks of UM patients in each integrative subtype. (A) Bimodal age distribution of UM patients. (B) Kaplan-Meier survival curves of patients in the two age groups in the two identified subgroups, IntSub1 and IntSub2.
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The reason we chose the threshold of 65 years old was because  Figure 4A  illustrates a bimodal age distribution, implying that we had two groups naturally. Observing the results reported in  Figure 4B , we revealed a significant survival difference between the two age groups in the IntSub2, whereas no statistical significance in patient outcome between the two age groups was seen in the IntSub1, indicating that age factor could be a risk factor to predict the survival time.