PMC4854225_01
A mass emanating from the supraglottic part of larynx without erosion or haemorrhage and a lesion of the true right vocal cold presenting as leukoplakia.
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figure1
Full head and neck examination was performed including flexible laryngoscopy revealing a mass emanating from the left supraglottic part of larynx without erosion or haemorrhage and a lesion of the true right vocal cold presenting as leukoplakia (Figure 1). Microlaryngoscopy and biopsy were performed (Figure 1).
Low-power view of the mass shows two neoplastic populations (sarcomatoid and epithelial component) and the overlying dysplastic epithelium (H&E, X40).
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figure2
(A) Low-power view demonstrates the neoplastic populations to intermingle (H&E, X100). (B) Low-power view shows the sarcomatoid component and the overlying epithelium (H&E, X100).
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figure3
Diffuse immunoreactivity of squamous cell carcinoma and the overlying epithelium for cytokeratin AE1/AE3 and focal/weak immunoreactivity of the sarcomatoid component (Immunoperoxidase with haematoxylin counterstain, X100).
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figure4
The cells of the two populations intermingled (Figure 4).
Small supraglottic mass just above the anterior commissure two months after initial treatment was excised with CO2 laser and proved to be a recurrence of histiocytoma. The patient remained disease-free nine months after the second look cordectomy.
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figure5
During follow-up period, two months after the operation a very small granulomatous-type exophytic mass was found just above the anterior commissure (Figure 5).