PMC9059067_01
The hemoglobin levels and absolute reticulocyte counts during the course of pure red cell aplasia (PRCA) post ABO-mismatched allo-HSCT. The red, and blue line represents hemoglobin levels, and absolute reticulocyte counts, respectively. Each red triangle refers to an incidence of red blood cell transfusion. The grey bar indicates s daratumumab infusion.
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No further daratumumab was administered due to the marked clinical improvement (Fig. 1).
ABO isoagglutinin titer during the treatment course of pure red cell aplasia (PRCA) post ABO-mismatched allo-HSCT. The blue, green, dark, red, and grey line represents anti-A IgM titers, anti-A IgG titers, anti-B IgM titers, and anti-B IgG titers, respectively. The grey bar indicates daratumumab infusion.
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Anti-B IgG titer increased to 1:2048, albeit hemoglobin improvement 2 weeks after daratumumab (Fig. 2). After 3 months of a single dose of daratumumab, his ABO blood type turned to donor B blood group with extremely low-titer anti-B IgG and IgM as shown in figure 2.