PMC5112301_01
Lymphocytosis in the peripheral blood.
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Peripheral smear showed marked mature lymphocytosis, composed of medium sized cells with mature clumped chromatin, round nuclear contours, moderate cytoplasm, severe thrombocytopenia and hypochromic, and normocytic anemia (Figure 1).
Bone marrow aspirate depicts the marked increase in lymphocytes. They are uniformly small with mature chromatin, scant cytoplasm, and inconspicuous nucleoli.
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Megakaryocytes were increased in number and showed adequate morphology (Figures 2, 3, and 4).
Diffuse involvement of the bone marrow by CLL as shown on this core biopsy specimen.
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Megakaryocytes were increased in number and showed adequate morphology (Figures 2, 3, and 4).
High-power view of the biopsy depicting the markedly increased number of small, mature-appearing lymphoid cells.
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Megakaryocytes were increased in number and showed adequate morphology (Figures 2, 3, and 4).
Cytogenetics showing translocation (2;14)(p16;q32). Orange arrow.
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Conventional cytogenetics demonstrated an abnormal male karyotype: 47,XY,t(2;14)(p16;q32),+12[cp11]/46,XY[1], significant for the presence of the t(2;14) translocation (BCL11A-IGH) and trisomy 12 (Figure 5).