PMC9929652_01
Family 1 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
crg-2022-0017-0001-529153_f1.jpg
PMC9929652_01_crg-2022-0017-0001-529153_f1.jpg
F1
HCC at 36, 6 years before, while his 38-year-old brother and 36-year-old sister both, HBsAg (+), are not on antiviral therapy. His youngest sister, also HBsAg (+), died of a myocardial infarction at age 31 (Fig. 1).
Family 2 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
crg-2022-0017-0001-529153_f2.jpg
PMC9929652_01_crg-2022-0017-0001-529153_f2.jpg
F2
Among her three sons, all perinatally infected, one died of HCC at the age of 44, while two others (ages 42 and 46) have CHB on treatment (Fig. 2).
Family 3 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
crg-2022-0017-0001-529153_f3.jpg
PMC9929652_01_crg-2022-0017-0001-529153_f3.jpg
F3
These three daughters presented with 3 different clinical manifestations, while their mother died of HCC (Fig. 3).
PMC9929652_02
PMC9929652_03
Family 4 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
crg-2022-0017-0001-529153_f4.jpg
PMC9929652_03_crg-2022-0017-0001-529153_f4.jpg
F4
HCC at 58 and in her 70's, respectively. Her older (6 years older) brother died of unknown cause (Fig. 4).