PMC5075614_01
Core-needle biopsy of a right axillary lymph node revealed Reed-Sternberg cells (red circle) in a background of fibrosis and mixed inflammatory infiltrate.
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Core-needle biopsy of a right axillary lymph node revealed Reed-Sternberg cells in a background of fibrosis and mixed inflammatory infiltrate (Figure 1).
Bone marrow core showed foci of fibrosis with CD30-positive cells.
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Bone marrow core biopsy revealed foci of fibrosis with rare CD30-positive cells, consistent HL (Figure 2).
Hemophagocytosis consistent with HLH was noted in the bone aspirate smears.
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Additionally, hemophagocytosis was noted in the bone marrow aspirate smears (Figure 3).
Pretreatment maximum intensity projection (MIP) scan of the whole body showed increased extensive lymphadenopathy above and below the diaphragm with multiple osseous foci of increased FDG uptake.
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PET scan at Cycle 3/Day 1 showed interval resolution of FDG avid lymphadenopathy and bone lesions.
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Restaging MIP scan showed complete response to treatment.
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Posttreatment bone marrow biopsy showed mild hypocellularity with erythroid hyperplasia and dyspoiesis in the absence of Reed-Sternberg cells or hemophagocytosis.
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