PMC6701396_01
Endoscopic evaluation demonstrating severe colitis throughout the colon.
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fig1
Flexible sigmoidoscopy showed ulceration of the splenic flexure, moderate to severe active colitis, ulceration at 30 cm, and active colitis in the rectum (Figure 1).
Histological features. (a, b) Distortion of the crypt architecture, inflammation of crypts (cryptitis), frank crypt abscesses, and hemorrhage or inflammatory cells in the lamina propria. (c) Intense inflammation of the mucosa is seen. (d) The colonic mucosal epithelium demonstrates loss of goblet cells. The shape of the crypts is distorted. Also, there are features of early dysplasia towards the bottom of the crypts as seen by the deep staining and crowded nuclei.
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fig2
Biopsies showed a collection of neutrophils within crypt lumens and architectural distortion, including shortening of crypts and variation in the sizes and shapes of crypts (Figure 2).