PMC8077466_01
The colonic biopsies showed a mean number of >60 eosinophils/HPF (x400) prior to treatment (a) and there was no eosinophil infiltration in colonic mucosa at posttreatment biopsy (b), indicating an improvement of eosinophilic inflammation with the use of combined therapy with montelukast and ketotifen.
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F1
Biopsies were randomly obtained from the colon at 3 different locations; all of them showed dense infiltration of eosinophils (>60 cells/HPF) in the lamina propria, muscularis mucosae, and submucosa (Fig. 1a). Subsequent colonoscopy still revealed patchy erythematous lesions in the colon, however, the eosinophils infiltration became less severe on the colonic biopsies (Fig. 1b).
The growth chart showed growth retardation from visits prior to montelukast and ketotifen therapy (arrowhead). The body weight caught up after adding montelukast and ketotifen therapy (dotted-line arrow). Moreover, the growth curve remained even after the cessation of medications (solid-line arrow).
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F2
The blood-tinged diarrhea gradually improved, and the body weight gain achieved the ideal growth even after stopping the oral medications (Fig. 2).