PMC9285531_01
(A) Pre-operative view of Lymphangioma in interdental gingiva between teeth 21 and 22 [Site A]. (B) Preoperative view of Lymphangioma in interdental gingiva in the palatal aspect between teeth 22 and 23 [Site B]. (Mirror image).
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The swelling was approximately 5mm X 5 mm in diameter (Figure 1A and B).
Intraoral Periapical radiograph showing minimal bone loss in interdental aspect of teeth 21 and 22 [Site A].
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Intra-oral periapical radiographs of the area did not show any significant bone changes (Figure 2).
(A) H & E staining - 40X magnification: Section showing tissue lined by squamous epithelium with underlying dilated lymphovascular channels. (B) (1) Surface epithelium. (2) Endothelium lined enlarged vessels. (3) Melanin incontinence. (4) Inflamed connective tissue.
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B (Figures 3 and 4). Both sides had a similar appearance in histologic examination.
(A) H&E staining X10 magnification and (B) H&E staining X40 magnification. Histopathological examination showed parakeratinized stratified squamous epithelium (Red arrow). The juxtaepithelial connective tissue showed homogeneous eosinophilic areas resembling lymph lined by endothelium (Yellow arrow) with interspersed lymphocytes, occasional plasma cells, tissue macrophages, and red blood cells (RBC). The connective tissue was densely collagenous with interlacing bundles of collagen fibres, fibroblasts, and blood vessels (Black arrow).
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B (Figures 3 and 4). Both sides had a similar appearance in histologic examination.
(A) X10 magnification (B) X40 magnification: Immunohistochemical stain (D2-40) highlights the lymphoid spaces and channels.
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Immunohistochemistry using D2-40 (Lymphatic marker) was done in the formalin fixed paraffin-embedded (FFPE) tissues which showed a positive staining reaction (Figure 5).