PMC8020741_01
a,b Intra- and post-operative FVIII trough activity levels measured by one-stage assay during the presented neurosurgical procedures in case 1 (a) and case 2 (b). Administered EHL FVIII doses are provided as IU per kilogram bodyweight.. EHL, extended half-life; IU, international units.
10.1177_2040620721993686-fig1.jpg
PMC8020741_01_10.1177_2040620721993686-fig1.jpg
fig1-2040620721993686
FVIII activity >80% during all timepoints. Figure 1a displays the timepoints of rFVIIIFc administration and the corresponding FVIII activity levels. FVIII activity >60%. Following the haemostatic management plan, no bleeding occurred during or after complete resection of the temporal astrocytoma and FVIII activity remained >90% at all measurements (shown in Figure 1b). A similar perioperative rFVIIIFc substitution concept was followed and again no relevant bleeding complications occurred, and FVIII activity remained >100% during the hospital stay (shown in Figure 1b).