PMC5687541_01
Proinflammatory cytokine production from whole blood assay (case 1) in response to lipopolysaccharide (LPS) and after LPS/IL-10 combination (A,B,C). Picture of inflamed skin/joints, case 1 (D).
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F1
A 54-year-old man presented at the age of 35 years with episodic night sweats, fever, erythematous skin rash and bilateral symmetrical synovitis suggestive of RA (figure 1). His lipopolysaccharide (LPS)-stimulated Peripheral mononuclear cells (PBMC) produced considerably higher levels of IL-1beta compared with healthy controls. (figure 1).
PMC5687541_02
Proinflammatory cytokine production from whole blood assay (case 2) in response to lipopolysaccharide (LPS) and after LPS/IL-10 combination (A,B,C). Picture of inflamed skin/joints, case2 (D).
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F2
This response was poorly downregulated by IL-10 (figure 2).
PMC5687541_03
PMC5687541_04
PMC5687541_05