PMC6215581_01
A PET/CT scan showed hypermetabolic lymphadenopathy involving cervical, supraclavicular, axillary, pelvic, and inguinal nodes and findings consistent with malignant infiltration of the bilateral kidneys and spleen (a). Low-power examination of the lymph node showed distortion of the lymph node architecture, with expansion of the paracortex (b) (H&E, 40X magnification). High-power examination of the paracortex showed a mixed inflammatory infiltrate with increased eosinophils and scattered large cells (c) (600X). An immunohistochemical stain for CD30 highlighted a patchy increase in large immunoblasts (d) (400X).
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fig1
A PET scan revealed diffuse hypermetabolic lymphadenopathy involving cervical, supraclavicular, axillary, pelvic, and inguinal nodes, as well as findings consistent with malignant infiltration of the bilateral kidneys and spleen (Figure 1(a)). Secondary follicles were largely absent (Figures 1(b) and 1(c)). CD3 highlighted numerous T cells in the paracortex and interfollicular areas. CD15 highlighted granulocytes. CD30 highlighted scattered large immunoblasts, including rare Reed-Sternberg-like cells (Figure 1(d)); no sheets of positive cells were seen.