PMC9478332_01
Preoperative chest CT scan (A-C); postoperative chest CT scan after more than a year of follow-up (D-F).
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F1
Computed tomography (CT) revealed thickened pleura on the right anterolateral aspect of the chest wall, a soft tissue mass adjacent to the chest wall surrounding part of the 3rd and 4th ribs, a big pulmonary bulla with a size of 4.4 cm x 5.1 cm, and normal mediastinal lymph nodes (Figures 1A-C). After more than a year of follow-up, no sign of tumor recurrence was detected (Figures 1D-F).
(A) The neoplastic cells were arranged in the form of nests with different sizes and showed various intercellular bridges (H&E stain, magnification x40). (B) The cells were round or ovoid, with abundant cytoplasm, large nuclei, apparent nucleoli, and intracellular keratinization in focal areas (H&E stain, magnification x100). (C) Squamous cell carcinoma invading the adjacent ribs (H&E stain, magnification x40). (D) Pulmonary bullae with chronic inflammation (H&E stain, magnification x40). (E,F) Immunohistochemical staining of neoplastic cells was performed with the use of antisera against p40 and p63, respectively, which showed evident nuclear positivity for both (E) p40 and (F) p63.
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F2
The wall of the pulmonary bulla showed chronic inflammation (Figures 2A-D). The immunohistochemistry staining showed positive results of P63 and P40 and negative results of TTF1, napsin A, WT1, D2-40, c-kit, and calretinin (Figures 2E,F).