PMC4142907_01
Poorly differentiated adenocarcinoma of antropyloric region is shown. The signet ring cells infiltrate the muscular wall of stomach.
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It has comprised of diffuse sheets of signet ring cells (Figure 1).
Gastrointestinal Stromal Tumor (GIST) of stomach is shown. The neoplastic cells have uniform spindle nuclei, eosinophilic fibrillar.
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In microscopic examination it was a spindle cells neoplasm located in muscularis propria extending up to serosa composed of intersecting fascicles of spindle cells with abundant eosinophilic fibrillar cytoplasm and minor degree of nuclear pleomorphism (Figure 2).
GIST with focal cytoplasmic staining for desmin
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In immunohistochemical study focal positivity for desmin (Figure 3) and diffuse strong positivity for CD117 (Figure 4) have detected which has confirmed the diagnosis of gastrointestinal stromal tumor.
GIST showing diffuse and strong membranous and cytoplasmic staining for CD117 (c-kit).
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In immunohistochemical study focal positivity for desmin (Figure 3) and diffuse strong positivity for CD117 (Figure 4) have detected which has confirmed the diagnosis of gastrointestinal stromal tumor.