PMC9946752_01
Color (a) and infrared (b) imaging of the limbal mass on initial examination of the left eye.
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fig1
Abnormal ocular findings in OS included a raised, white, exophytic mass originating from the temporal limbus extending to the medial paraxial cornea (approximately 20 mm long x 10 mm wide x 8 - 10 mm thick) with perilesional corneal edema 1-2 mm beyond the leading edge of the base of the mass (Figure 1).
A partial incision superficial lamellar keratectomy (PI-SLK) and conjunctivectomy; removal of the corneoconjunctival section (a-d), "painting" of infracyanine green onto the keratectomy site and injection into the perilimbal conjunctiva (e), and infrared imaging showing no gross evidence of infiltrate (f).
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fig2
A partial incision superficial lamellar keratectomy (PI-SLK) and conjunctivectomy was performed (Figures 2(a)-2(d)). Following PI-SLK and conjunctivectomy, photodynamic therapy was performed as follows: one milliliter of EmunDo  (infracyanine green (InfraCG)) was applied topically ("painted") to the keratectomy site and injected into the perilimbal conjunctiva until the entire surgical site was coated with InfraCG (Figure 2(e)). There were 28 mitotic figures in ten 400x fields (2.37 mm2) (Figure 3).
Lateral limbal lesion from a cow. Photomicrograph of the specimen showing the plaque-like exophytic neoplasm that replaced that conjunctival and corneal epithelium. The cells formed sheets and anastomosing lobules, which multifocally invade below the basement membrane (arrow). The superficial surface of the mass was composed of dense keratin (bracket). Inflammatory cells heavily infiltrated the underlying stroma. The margins were clear of neoplastic cells. Hematoxylin and eosin.
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fig3
There were 28 mitotic figures in ten 400x fields (2.37 mm2) (Figure 3).
Color (a) and infrared (b) imaging of the left eye 1 week after surgery. Granulation of the keratectomy site is noted with no evidence of tumor regrowth.
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fig4
One week after surgery, the patient was comfortable with mild conjunctival hyperemia and granulation of the keratectomy site (Figure 4).
Color (a) and infrared (b) imaging of the left eye 11 months after surgery. Faint fibrosis is noted along the temporal limbus with no evidence of tumor regrowth.
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fig5
Eleven months after surgery, the patient remained comfortable with only faint fibrosis of the cornea and no signs of tumor recurrence (Figure 5).