PMC9372331_01
Heart rate (HR) and mean arterial pressure (MAP) within the first 36 h after admission to the intensive care unit. ECMO, extracorporeal membrane oxygenation.
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F1
Then, 30 min later, she developed another bout of anaphylaxis (Figure 1) and rapidly deteriorated with a fall in blood pressure (>30%) to 70/47 mmHg.
Time course of tryptase levels within the first days and follow-up. The half-life of tryptase between days 2 and 5 was about 32 h. This is in stark contrast to the normal tryptase half-life of 2 h. This indicates ongoing mast cell activation for a couple of days after the initial peak. ECMO, extracorporeal membrane oxygenation.
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PMC9372331_01_falgy-03-934436-g0002.jpg
F2
Severe mast cell activation was suspected because tryptase levels were increased >50-fold the upper normal limit, and omalizumab 300 mg was injected subcutaneously (Figure 2).