PMC3420746_01
CT chest showing mediastinal lymphadenopathy and bilateral axillary enlarge lymph nodes.
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fig1
CT scan of the thorax, abdomen, and pelvis revealed multiple symmetrically enlarged lymph nodes in the mediastinum and axilla (Figure 1) and splenomegaly.
(a) Showing lymph node with vague nodularity morphology as indicated by the arrows (magnification 40x). (b) shows multinucleated (classical) Reed-Stemberg cell. (40x magnification).
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fig2
Lymph node biopsy demonstrated a vague nodular pattern (Figure 2(a)) composed of numerous small cells and large atypical Reed-Sternberg cells (Figure 2(b)) within the nodules and outside of germinal centers; rare eosinophils and neutrophils were noted.
(a) Immunohistochemistry stain showing RS cells positive for CD30 (magnification 40x). (b) Immunohistochemistry stain showing RS cells positive for CD20 (magnifications 40x).
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fig3
Immunohistochemical stains indicated the RS cells being positive for CD30 (Figure 3(a)) and CD20 (Figure 3(b)) and negative for CD15 (Figure 4(a)) and lymphocyte common antigen (Figure 4(b)).
(a) shows large atypical lymphocyte identify by the arrow negative for CD15 (magnification 40x). (b) Immunohistochemistry showing RS cells negative for lymphocyte common antigen (LCA) (magnification 40x).
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fig4
Immunohistochemical stains indicated the RS cells being positive for CD30 (Figure 3(a)) and CD20 (Figure 3(b)) and negative for CD15 (Figure 4(a)) and lymphocyte common antigen (Figure 4(b)).