PMC7448262_01
This line graph demonstrates the rapidity in which the liver enzymes increased after a single dose of propylthiouracil (PTU). As shown, hour 0 is when the initial dose of PTU was administered. The aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels started to increase immediately after the first dose. At hour 9, as depicted by the single star, PTU was considered the etiology behind acute liver injury and was discontinued after the initial dose. Subsequently, AST and ALT levels peaked at 1127 IU/L and 1004 IU/L, respectively. At hour 62, as depicted by the double star, methylprednisolone was started. It resulted in the eventual normalization of liver enzymes.
10.1177_2324709620951323-fig1.jpg
PMC7448262_01_10.1177_2324709620951323-fig1.jpg
fig1-2324709620951323
Nine hours after the initial dose of 200 mg PTU, the patient's aspartate aminotransferase and alanine aminotransferase levels showed significant elevation, eventually peaking at 1127 IU/L and 1004 IU/L, respectively (Figure 1).