PMC5414059_01
(A) High-power view of neutrophil-rich ring granulomas in brucellosis. (B) CD163 immunostain for histiocytes highlights extensive infiltration of the marrow by granulomas.
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F1
A bone marrow biopsy was performed that was negative for blasts but showed numerous neutrophil-rich ring granulomas comprising 20%-30% of the marrow cellularity (Figure 1).
The Gram stain from bone marrow culture demonstrated small Gram-negative coccobacilli. This was later confirmed as Brucella melitensis.
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F2