PMC3310281_01
Clinical picture of case 1.
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fig1
The associated teeth were mobile, and both the lingual and buccal sulci were obliterated by the tumour mass (Figure 1).
Oblique lateral views of the mandible and posteroanterior view of the jaws for case 1 demonstrating an osteolytic lesion (with centrifugal radiopaque spikes) within which the faint presence of an irregular, shapeless mass of radiopacity can be seen-white arrow.
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fig2
The radiographic appearance is as shown in Figure 2.
(a) Osteoblastic variant of osteogenic sarcoma of case  1 showing osteoblasts with cytonuclear pleomorphism and hyperchromatic nuclei surrounding malignant osteoid (X100). (b) Cemento-osseous dysplasia showing a benign mesenchymal neoplasm composed of irregular islands of immature bone with osteoblastic rimming surrounded by a moderately dense fibrous connective tissue stroma (X100). (c) A possible transition zone between osteogenic sarcoma and cemento-osseous dysplasia (X400). (d) Chondroblastic osteosarcoma of case 2 showing a malignant mesenchymal neoplasm consisting of pleomorphic chondroblast with prominent hyperchromatic nuclei amidst malignant osteoid(X100).
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fig3
An incisional biopsy of the right mandibular lesion revealed chondroblastic osteogenic sarcoma (Figure 3(d)).
PMC3310281_02
(a) Osteoblastic variant of osteogenic sarcoma of case  1 showing osteoblasts with cytonuclear pleomorphism and hyperchromatic nuclei surrounding malignant osteoid (X100). (b) Cemento-osseous dysplasia showing a benign mesenchymal neoplasm composed of irregular islands of immature bone with osteoblastic rimming surrounded by a moderately dense fibrous connective tissue stroma (X100). (c) A possible transition zone between osteogenic sarcoma and cemento-osseous dysplasia (X400). (d) Chondroblastic osteosarcoma of case 2 showing a malignant mesenchymal neoplasm consisting of pleomorphic chondroblast with prominent hyperchromatic nuclei amidst malignant osteoid(X100).
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fig3
An incisional biopsy of the right mandibular lesion revealed chondroblastic osteogenic sarcoma (Figure 3(d)).
An orthopantomogram of the patient in case 2 showing a significant bone destruction of the right mandible extending from the lower right lateral incisor to a region just short of the mandibular angle. The radiolucency also encompasses the irregular mass of radio-opacity just apical to right mandibular first molar. The radiograph shows a similar irregularly shaped radio-opacity within the body of the left mandible.
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fig4
The radiograph shows a similar irregularly shaped radio-opacity within the body of the left mandible (Figure 4).