PMC5836239_01
a Microscopic findings of the hysterectomy specimen showed small cell carcinoma. H&E stain. x200. b Immunohistochemical (IHC) staining showed tumor cells positive for synaptophysin and chromogranin. IHC stain. x400.
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F1
IIb. Immunohistochemical staining showed tumor cells positive for synaptophysin and chromogranin (Fig. 1a, b).
a Mammograms showed a well-defined, round, and lobulated mass in the upper outer quadrant of the right breast. b Ultrasound examination demonstrated 3.0-cm sized heterogeneous, hypoechoic, irregular-margined masses of the right breast. c Microscopic findings of the mastectomy specimen were compatible with the diagnosis of metastatic small cell carcinoma. H&E stain. x400. d By immunohistochemical (IHC) staining, the tumor cells were strongly positive for synaptophysin and chromogranin. IHC stain. x400.
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F2
Mammograms showed a 2.5-cm sized, well-defined, round, and lobulated mass in the upper outer quadrant of the right breast, suggesting a well-circumscribed breast cancer (Fig. 2a). Ultrasound examination demonstrated 3.0 x 3.0 x 3.0 cm and 1.7 x 1.0 x 2.0 cm sized heterogeneous, hypoechoic, irregular-margined masses in the right breast (Fig. 2b). The findings of multiple lesions, the absence of in situ carcinoma, well-demarcated tumors, and a history of SCC were compatible with the diagnosis of metastatic SCC (Fig. 2c). Immunohistochemical staining showed tumor cells strongly positive for synaptophysin and chromogranin (Fig. 2d) and negative for CK-20 and CK-7.