PMC5488115_01
Morphology of leukemia at diagnosis (case report #1: BCP-ALL). a Blood smear showing small to medium size blast cell, with fine and pearly chromatin, evocative of lymphoid blast. b Bone marrow aspirate picture in optic microscopy (May-Grunwald-Giemsa) showing extensive marrow necrosis. Cells cannot be identified. c Bone marrow trephine biopsy showing a fibrotic marrow with a low cellularity but a massive blastic infiltration
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Fig1
Bone marrow aspirate revealed a hypocellular marrow with extensive necrosis and pycnotic features in most of the cells (Fig. 1).
PMC5488115_02
Morphology of leukemia at diagnosis (case report #2: AML). a Blood smear showing an aspect of myeloid blasts with monocytic differentiation. b Bone marrow aspirate picture in optic microscopy (May-Grunwald-Giemsa) showing extensive marrow necrosis. Cells cannot be recognized, showing indistinct outlines and pycnotic nuclei. c Bone marrow trephine biopsy showing a hypercellular marrow with extensive necrosis. Majority of cells are necrotic but however suggestive of blastic cells
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Fig2
Bone marrow aspirate revealed extensive necrosis of hematopoietic tissue (Fig. 2).