PMC4307870_01
Two-minute segment of full polysomnography (TPM: 250 mg per day) showing periodic limb movement during NREM sleep (N2). The muscle contractions of the anterior tibialis (RTib and LTib) and of the chin (EMG) occur after the onset of the A phase (A2 and A3) of the cyclic alternating pattern and follow the same cyclic recurrence. The TPM withdrawal induced the progressive reduction of PLMS and CAP rate, particularly phases A2 and A3, considered a marker of sleep instability.
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In particular, CAP oscillations were triggered by PLM with higher presence of CAP subtypes A2 and A3 (see Fig. 1).