PMC5757106_01
(a) Portal venous phase contrast-enhanced CT shows several small hypoattenuating lesions with slight peripheral enhancement. (b) Two days later, CT shows progression with multiple large hypoattenuating lesions in both the left and right lobe of the liver, suggestive of liver abscesses. (c) Time course of LAmB dosage, serum posaconazole, and serum bilirubin levels. Taking into account the long serum terminal half-life and mean residence time in the liver tissue of LAmB, the graph suggests that LAmB was an important contributor to the cholestasis and hepatotoxicity (as measured by total bilirubin levels) observed in our patient.
CRIID2017-4173246.001.jpg
PMC5757106_01_CRIID2017-4173246.001.jpg
fig1
Abdominal computed tomography (CT) on day 9 revealed generalized lymphadenopathy, edematous thickening of the cecum, and a few small, hepatic hypoattenuated lesions presumed to represent bacterial abscesses (Figure 1). Repeated abdominal CT on day 11 showed extensive progression of hepatic lesions (Figure 1). Subsequently, bilirubin levels gradually decreased (Figure 1).