PMC4246607_01
(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the bone window showing an osteolytic lesion with expansion and a periosteal reaction with the appearance of sunrays around the periphery (arrows). (B) Sagittal reconstructed CT image of the sternum showing the lesion involving the manubrium and almost all the body of the sternum. The lesion is slightly expansile and the cortex is partially destroyed.
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There was no calcification in the lesion (Fig. 1).
(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the soft tissue window showing that the bone marrow of the sternum has been substituted by homogeneous soft tissue. (B) Axial contrast-enhanced CT image of the manubrium sterni showing marked homogeneous enhancement of the tumor.
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The tumor exhibited marked homogeneous enhancement on contrast-enhanced CT (Fig. 2).
(A) T1-weighted sagital image (repetition time/echo time, 590/21 msec) of the sternum showing an area of low signal intensity in the manubrium and body of the sternum. (B) Short-tau inversion recovery T2-weighted sagittal image (repetition time/echo time, 4150/106 msec) of the sternum showing an area of high intensity in the same region; the soft-tissue mass is clearly demonstrated.
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T1-weighted images, and a high signal intensity on short-tau inversion recovery T2-weighted images. The soft-tissue mass was clearly demonstrated (Fig. 3).
(A) Histopathological examination (hematoxylin and eosin stain; original magnification, x200) demonstrating proliferation of round cells with abundant cytoplasm and eccentric nuclei with coarse chromatin, indicating a plasmacytoma. (B) Immunohistochemical analysis revealing positive cluster of differentiation 38 staining on the cell membrane (arrow), which is characteristic of a plasmacytoma (original magnification, x200).
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Immunohistochemical staining was positive for immunoglobulin (Ig) lambda- and kappa-light chain antibodies, and cluster of differentiation (CD)38 and -138 (Fig. 4).