PMC3691546_01
Figure 1. Axial Brain MRI sequences prior to treatment. A: T2 weighted image, B: FLAIR showing abnormal signal prolongation in periventricular areas, C: post contrast T1 image showing mild diffuse enhancement.
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Figure1
A repeat brain MRI showed multifocal abnormal T2 prolongation in periventricular regions (Figure 1A, B) with contrast enhancement on T1-weighted images (Figure 1C).
Figure 2. A: Obliterated vascular lumen by reactive endothelial cells and infiltration of mature lymphocytes. B: Immunohistochemical staining for CD3 showing infiltration of T-lymphocytes.
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Figure2
Lumens were nearly obliterated by reactive endothelial cells and, percolating through the blood vessel walls, were populations of predominantly small mature appearing lymphocytes (Figure 2A) accompanied by reactive microglia or macrophages. T-lymphocytes and reactive microglia accompanied by some fibrous gliosis. The immunohistochemical staining for CD3 revealed that the angiocentric infiltrates were predominantly T-lymphocytes (Figure 2B).
Axial Brain MRI sequences after treatment. A: T2 weighted image, B: FLAIR, C: post contrast T1 image showing resolution of previously noted lesions.
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Figure3
A follow-up brain MRI demonstrated a significant resolution of the previously noted lesions (Figure 3). 