PMC8127741_01
Intraoral proliferative mass with overlying erythema and ulceration in the right lower mandible extending along the posterior oral mucosa.
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Worsening of his pain and swelling then prompted an emergency department visit where the patient was noted to have a soft tissue mass that extended posteriorly, as shown in Figure 1.
X-ray orthopantomogram showing large lytic lesion along the alveolar margin of the right submandibular body.
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XR orthopantomogram as shown in Figure 2.
Immunohistochemistry with hematoxylin and eosin stain. Diffuse proliferation of large atypical lymphoid cells with plasmablast features is seen. These cells have prominent round nuclei with eccentric amphophilic cytoplasm and clumped chromatin within the nuclei indicating increased mitotic activity. Immunohistochemistry results were positive for tumor markers CD45, CD79a, CD10, and lambda light chains. These cells were negative for CD19, CD20, CD22, CD138, PAX5, kappa light chains, and CD30. EBV testing showed nuclear positivity in most of the cells.
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Diagnosis of PBL was confirmed via biopsy, as shown in Figure 3.