PMC9382061_01
(a) Sheets of foamy histiocytes with scattered lymphocytes and exceptional
eosinophils. Touton (arrow) multinucleated cell (HE x40). (b) Dense
infiltrate of CD68 positive histiocytes (HE x10). (c) S100 negative with
positive internal control (HE x10). (d) CD1a negative with positive internal
control (HE x10).
10.1177_2050313X221117693-fig1.jpg
PMC9382061_01_10.1177_2050313X221117693-fig1.jpg
fig1-2050313X221117693
All histiocytes were positive for CD68 and were negative for CD1a and S100 (Figure 1).
(a) Multiple yellow papules and nodules on the head and upper trunk of
12-month-old patient. (b) Patient continued to develop new lesions while
others started to regress at 2 years old. (c) At the age of 4 years, most
JXGs had completely regressed leaving hyperpigmented macules.
10.1177_2050313X221117693-fig2.jpg
PMC9382061_01_10.1177_2050313X221117693-fig2.jpg
fig2-2050313X221117693
However, by the age of 4 years, most skin lesions had regressed leaving hyperpigmented macules and no new ocular lesion had appeared, while most conjunctival lesions had stabilized or regressed (Figure 2).