PMC3004203_01
Skin section (sacral lesion). a An intense chronic and diffuse inflammatory reaction can be observed, whereas the exudate is predominantly constituted by mononuclear cells involving calcified eggs and egg shells, in the dermis (arrows). Bars = 32 microm. b Higher magnification showing some eosinophils (arrowheads) and a detail of two S. mansoni eggs in the center of the figure. Bars = 16 microm. c Note a giant cell formation (arrowhead) engulfing a viable S. mansoni egg (arrow). Bars = 32 microm. d A calcified egg can be noted at the left corner of the figure. Bars = 16 microm.
cde0002-0001-f01.jpg
PMC3004203_01_cde0002-0001-f01.jpg
F1
An intense diffuse inflammatory infiltrate coexisted, predominantly comprising mononuclear cells and a moderate number of eosinophils, involving calcified eggs and egg shells, in the superficial, medium and deep reticular and papillary dermis, unlikely to form granulomas (fig. 1a-d).
Skin section (sacral lesion). a Observe two S. mansoni eggs where they are identified in the Malphigian layer of the epidermis: one represented by a shell (large arrow) and the other by a calcified egg (small arrow). Bars = 32 microm. b Higher magnification showing a detail of the egg with remains of miracidia into the epidermic layer. Bars = 16 microm. c Note an intense chronic inflammatory reaction in the dermis associated to an epidermic lesions as acanthosis and papillomatosis, hyper- and moderate parakeratosis and the association of junctional nevus-like lesion (arrows). Bars = 32 microm. d Tunnels made by parasites with no inflammatory reaction and with no morphological changes in epithelial cells can be observed. Bars = 16 microm.
cde0002-0001-f02.jpg
PMC3004203_01_cde0002-0001-f02.jpg
F2