PMC8660253_01
Histopathological image of the primary tumor. Atypical rounded cells with abundant clear cytoplasm, arranged in lobules, and admixed with trabeculae of woven bone and osteoclast-like giant cells (hematoxylin and eosin, original magnification (a) 100x and (b) 200x).
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Unni) confirmed the diagnosis of a clear cell chondrosarcoma (Figure 1).
Radiographic images of the suspected metastases. CT scan of a dense opacity in the left upper lung lobe of 6 mm in April 2016 (a). The nodule was unchanged after 6 months of follow-up (b). In December 2019, the nodule increased to 13.5 mm (c).
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On CT scan, two opacities in the left upper lobe were detected, with a diameter of 6 mm and 3 mm, respectively (Figure 2).
Lung metastasis. Histology of the wedge resection of the left upper lung lobe showing a 15 mm large, well-circumscribed chondroid tumoral lesion (hematoxylin and eosin, original magnification 12x (a)). Atypical rounded cells with a centrally placed, large round nucleus and abundant clear cytoplasm (hematoxylin and eosin, original magnification 100x (b)). Presence of osteoclast-like giant cells, a chondroid matrix, and calcifications (hematoxylin and eosin, original magnification 200x (c)). Diffuse expression of the tumor cells for S100 (original magnification 200x (d)) and Podoplanin (D2-40) (original magnification 200x (e)).
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Histopathological examination of the lung biopsy showed the presence of an atypical chondroid tumoral proliferation composed of atypical spindled to rounded chondroid cells embedded in a chondroid matrix (Figure 3). The atypical cells stained strongly with antibodies against S100 and Podoplanin (D2-40), further confirming the diagnosis of a lung metastasis of the known clear cell chondrosarcoma (Figure 3).