PMC5640091_01
Brain MRI (sagittal plane) showing normal size of the pituitary.
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F1
Brain MRI was normal (see figure 1), excluding metastatic involvement of the pituitary gland but not hypophysitis, which has also been described in the absence of pituitary gland enlargement.
The patient's exfoliative dermatitis at baseline (left) and in March 2017 (right).
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F2
At physical examination in March 2017, the patient had a PS of 0, was alert, afebrile, with normal blood pressure, good appetite and disappearance of skin exfoliation (see figure 2).
Serum hormone levels over time.
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F3
ACTH within normal range (table 1, figure 3). A CT scan of the neck, chest and upper abdomen performed in April 2017 revealed stable disease in the neck, lung and mediastinum (Figure 4).
CT scan of the thorax performed in April 2017 after nivolumab therapyshowing prolonged stability of  malignancy
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F4
ACTH within normal range (table 1, figure 3). A CT scan of the neck, chest and upper abdomen performed in April 2017 revealed stable disease in the neck, lung and mediastinum (Figure 4).