PMC5726751_01
Preoperative computed tomography shows an enhancing left breast mass, 0.8 cm in diameter (red arrow).
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It was not associated with the enlargement of the ipsilateral axillary lymph nodes (Fig. 1).
Macroscopic findings of the breast segmental resection.
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The metastasectomized specimen contained a whitish, well-defined, solid mass measuring 0.7 x 0.6 cm (Fig. 2).
Histological findings (H&E, x200) and immunohistochemical staining of the surgical specimen. On H&E staining, A: the specimen was composed of cells with the clear cytoplasm of primary renal clear cell carcinoma. B: the breast metastatic site was composed of clear cells. C: the pancreatic tumor was composed of well-differentiated neuroendocrine tumor. On immunohistochemical staining, CD10 (x100) was positive in D: the primary renal cell carcinoma and E: the breast metastatic site, but was negative in F: the pancreatic tumor.
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These findings did not support the diagnosis of NET but rather RCC as the primary site (Fig. 3A, B and C). IHC of each tissue was positive for CD-10 in the metastatic site and RCC but was negative in the pancreas (Fig. 3D, E, and F).