PMC9899457_01
Computed tomography brain scan showing two (right frontal and left basal ganglia) ring contrast-enhancing brain-occupying lesions with associated vasogenic edema.
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F1
(a) Whole-body computed tomography (CT) scan showing mural thickening at an ileal segment (red line). (b and c) PET-CT scan showing a significant uptake at the same engrossed segment founded in CT scan. (F): Frontal.
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F2
A whole-body CT and a 18F-FDG PET/CT scan were performed [Figure 2]. The whole-body CT scan showed mural thickening extending 30 mm at the level of distal ileum, close to the ileocecal valve [Figure 2a]. The PET/CT showed a significant pathologic uptake of 18F-FDG, represented by a 10.2 SUVmax (Maximum Standardized Uptake Value) at the same site of detected mural thickening [Figures 2b and c].
Colonoscopy showing mural thickening and ulcerated lesion in an ileal segment close to the ileocecal valve, corresponding to the findings in imaging.
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F3
A diagnostic colonoscopy was performed, revealing an ulcerated and mural-engrossed ileal segment [Figure 3], corresponding to the location of mural thickening and increased 18F-FDG uptake noted in the aforementioned imaging.
Brain biopsy IHQ analysis. (a) H&E x4. b. H&E x20. Signet-ring cells. (c) CEA x10. (d) CK7 x20. (e) CK20 x20. (f) CDX2 x10
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F4
These findings are shown in [Figure 4].