PMC6147964_01
Photomicrograph of the surgical specimen [H&E stain X20] showing sheets of cells with scant cytoplasm and dark, round nuclei, and increased mitotic figures.
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The cells showed scant cytoplasm and round-to-oval nuclei with coarse granular chromatin, exhibiting increased mitotic activity (>20/10 HPF in areas) and karyorrhexis (Figure 1).
Photomicrograph:Immunohistochemistry [NSE X40] Diffuse strong membrane cytoplasmic positivity for neuron-specific enolase.
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Immunohistochemistry showed positivity for neuron-specific enolase (Figure 2), enomysial antibody, chromogranin (Figure 3) and focal positivity for keratin.
Photomicrograph:Immunohistochemistry [CK20 X 40] Occasional tumour cells showing strong cytoplasmic positivity.
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Immunohistochemistry showed positivity for neuron-specific enolase (Figure 2), enomysial antibody, chromogranin (Figure 3) and focal positivity for keratin.