PMC6607934_01
A black nodule (8 x 7 cm) with a dark-red nodule on the back (a). Histological findings of the primary tumor before treatment: markedly atypical melanocytes arranged in irregular nests and solitary units (b). Multiple lung metastases (c), cutaneous, pharyngeal, and peritoneal nodules, lymph node metastases, and bone metastases on PET-CT (d). After treatment, multiple lung metastases are decreased (e). Histological findings of the primary tumor after single administration of nivolumab with ipilimumab showing dense infiltration of lymphocytes in the melanoma lesion (f).
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F1
At the initial physical examination, a black nodule (8 x 7 cm) with a dark-red nodule was seen on the back (Figure 1a). Biopsy of the primary tumor showed markedly atypical melanocytes arranged in irregular nests and solitary units (Figure 1b). PET-CT showed multiple lung (Figure 1c), cutaneous, pharyngeal, and peritoneal nodules, as well as lymph node and bone metastases (Figure 1d).