PMC9063503_01
(a) Right thyroid FNA. Cellular smear showing predominantly discohesive plasmacytoid cells of variable sizes (Giemsa stain, x400). (b) Few binucleate and multinucleate cells present. Background shows a few scattered lymphoglandular bodies (Giemsa stain, x600). (c) Cells have eccentric nuclei with finely stippled chromatin and moderate amount of cytoplasm (Papanicolaou stain, x400). (d) Discohesive plasmacytoid cells. (Giemsa stain, x1000).
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F1
Fine-needle aspiration (FNA) of the largest thyroid nodule (3 x 3 x 2 cm) is shown in Figure 1. Thyroid FNA smears were highly cellular, showing predominantly discohesive plasmacytoid cells of variable sizes [Figure 1a]. Also seen were binucleate and multinucleate cells [Figure 1b]. The cells had eccentric nuclei with finely stippled chromatin and moderate amount of cytoplasm [Figure 1c].
Cells expressing LCA immunoreactivity (ICC, x400).
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F2
One Pap stained slide was then destained for immunocytochemistry (ICC) and the cells showed strong immunoreactivity for leukocyte common antigen (LCA) (CD45) [Figure 2].