PMC7468649_01
Histopathological section of the oral intraductal papilloma. (a) The cystic cavity filled by papillary tumor projections and anastomosing proliferations of columnar epithelial cells in a fibrovascular core (haematoxylin and eosin stain, H&E, original magnification x5). (b-d) Note that the cystic wall is lined by uniform layers of cuboidal/columnar oncocytic epithelial cells, with no nuclear atypia or mitotic figures (H&E, original magnification x10 (b), x20 (c), x40 (d)). (e, f) Note the mucous cells showing positivity for periodic acid-Schiff, presence of mucous material in the lumen and minor salivary gland acini in fibrous tissue (P.A.S., x5 (e), x20 (f)).
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fig1
The lesion is surrounded by a thick, fibrous tissue wall (Figures 1(a)-1(d)). Mucous secretory cells and mucous material exhibited positivity for periodic acid-Schiff staining (P.A.S.) (Figures 1(e) and 1(f)).