PMC4795485_01
Renal biopsy sections. Light microscopy revealed marked interstitial inflammatory infiltrates consisting of lymphocytes and occasional eosinophils (inset, arrow head) (A). Inflammation extended into the walls of the tubules (arrow) (B), while the glomeruli showed a normal appearance (C). HE stain (A) and PAS stain (B and C); the scale bar is indicated in each panel.
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The glomerular structures were preserved, while there was marked diffuse infiltration with lymphocytes and some eosinophils accompanied by a partial destruction of the tubular structures (Fig. 1).
Changes in the sCr level, urine level of b2MG, and urine level of NAG during the observation period. The number "0" is designated as the point of admission. One week before admission, LVFX was withdrawn and steroid treatment was started on clinical day 11. Note the transient increases in both the urine levels of b2MG and NAG after the onset of uveitis despite the fact that the sCr levels were nearly constant.
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A diagnosis of TINU syndrome was made thereafter, and she was treated with topical corticosteroids for the eyes when the urinary b2MG excretion levels increased to 11,694 mug/L despite the finding that her sCr levels were nearly constant (Fig. 2).