PMC4060399_01
42-year-old male with fever, chest pain, and fatigue diagnosed with sarcoidosis. Pre-treatment 18F- FDG PET-CT total body scans of the patient from the base of the skull to the thighs: (a) CT scan, (b) PET scan, (c) Fusion coronal image, and (d) Maximum Intensity Projection (MIP) image show multiple abnormal uptakes of F18-FDG. In particular, some abnormal accumulations of radiotracer are present at the level of right pulmonary hilum, liver, and spleen (arrows in c).
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F1
Total body PET- imaging revealed hypermetabolic activity in multiple organs including lungs, liver, spleen, mediastinum, and lymph node chains above and below the diaphragm [Figures 1 and 2].
42-year-old male with fever, chest pain, and fatigue later diagnosed with sarcoidosis. Pre-treatment 18F-FDG PET- CT scan, transaxial fusion image at the level of the upper abdomen shows abnormal uptakes of radiotracer in the liver and spleen (arrows).
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F2
Total body PET- imaging revealed hypermetabolic activity in multiple organs including lungs, liver, spleen, mediastinum, and lymph node chains above and below the diaphragm [Figures 1 and 2].
42-year-old male with fever, chest pain, and fatigue later diagnosed with sarcoidosis. Photomicrograph of the biopsy sample stained with hematoxylin and eosin shows confluent sarcoid granulomata pattern in thoracic lymph node (arrows). Tissue showed occasional multinuclear giant cells Langhans type, mononuclear phagocytes, and lymphocytes. No necrosis was present (x100).
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F3
SUV value in this patient was 11.2. Surgical biopsies from the thoracic lymph nodes revealed confluent noncaseating granulomas with multinuclear giant cells, mononuclear phagocytes, and lymphocytes [Figure 3].
42-year-old male with fever, chest pain, and fatigue later diagnosed with sarcoidosis. Post treatment total body 18F-FDG PET/CT scan: (a) CT scan, (b) PET scan, (c) Fusion coronal image, and (d) MIP image show a physiological distribution of the radiotracer and the complete disappearance of abnormal uptakes at level of right pulmonary hilum, liver, and spleen (arrows in c).
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F4
Fifteen months after initiating therapy, the patient reported total resolution of symptoms and his repeat PET-CT scan was now normal [Figure 4].