PMC8995656_01
Clinical manifestations of a patient who developed adrenal insufficiency after starting on brodalumab. a, b Before starting on brodalumab, diffuse erythema with scales involving the entire body, including the back and lower legs, is evident (PASI score 26.2). c Decreased range of motion of the shoulder joints with increasing stiffness and pain after 6 weeks of brodalumab therapy. d Restored range of motion of the shoulder joints after taking low doses of corticosteroids.
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F1
On physical examination, he had diffuse, scaly erythematous plaques on his trunk, arms, and legs (Fig. 1a, b). Limited range of motion of the shoulder joints was noted (Fig. 1c). He was started on low-dose corticosteroid therapy (hydrocortisone 15 mg) and his symptoms of adrenal insufficiency resolved, with range of motion also restored in the shoulder joints (Fig. 1d).