PMC6587379_01
Annular generalized pustular psoriasis: widespread pustular lesions over an erythematous base forming a circinate pattern. (a) Right upper arm, (b) forearms bilaterally, (c) trunk and (d) back.
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On examination, she presented with a generalized poly-annular and poly-cyclic pustular and papular eruption with trailing scale and erythema affecting 50% of her body - including the trunk and limbs but sparing the face (Figure 1).
Histological examination of annular generalized pustular psoriasis: (a) H&E staining demonstrates classic psoriasiform changes of acanthosis, parakeratosis, subcorneal pustules, mild spongiosis and (b) histochemical staining demonstrates IL-17A in dermal infiltrates.
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Immunohistochemical analysis of lesional skin demonstrated interleukin (IL)-17A expression by the epidermis and dermal lymphocytes (Figure 2(b)).
PMC6587379_02
Histological examination of annular generalized pustular psoriasis: (a) H&E staining demonstrates classic psoriasiform changes of acanthosis, parakeratosis, subcorneal pustules, mild spongiosis and (b) histochemical staining demonstrates IL-17A in dermal infiltrates.
10.1177_2050313X19857392-fig2.jpg
PMC6587379_02_10.1177_2050313X19857392-fig2.jpg
fig2-2050313X19857392
Immunohistochemical analysis of lesional skin demonstrated interleukin (IL)-17A expression by the epidermis and dermal lymphocytes (Figure 2(b)).