PMC4506800_01
PMC4506800_02
Histologic sections (HESx 100) of peritoneal biopsy showed polyhedral tumor cells with abundant eosinophilic cytoplasm, with a sinusoidal arrangement of vascular channels resembling liver without bile
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Histologic sections of the biopsied peritoneal carcinomatosis showed polyhedral tumor cells with abundant eosinophilic cytoplasm, central round vesicular nuclei with variably prominent nucleoli in nests and trabeculae with a sinusoidal arrangement of vascular channels resembling liver without bile (Figure 1).
Immunohistochemical staining of the peritoneal biopsy showed a diffusely and overwhelmingly expression of the hepatocyte paraffin-1
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The results showed that tumor cells were positive for hepatocyte paraffin-1 which was diffusely and overwhelmingly expressed (Figure 2).
CT scan cut before chemotherapy showing peritoneal implants, right adnexal masse of 6.8 x 9.9 cm
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AFP, S-100 protein, synaptophysin, inhibin, calretinin and epithelial membrane antigen were all negative. A computed tomography (CT) scan of the pelvis showed an extensive omental peritoneal implants and bilateral adnexal masses with 6.8 x 9.9 cm on right (Figure 3) and 3.9 x 4.1cm on left.
Positron emission tomography scans with FDG showing an intense hypermetabolisme in the pelvic (SUV max: 3.3) with no uptake in the liver
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The patient got then after a positron emission tomography scan (PET/CT) with fludeoxyglucose (FDG) which revealed a metastatic disease with an intense hypermetabolisme in the pelvic with standard uptake value SUV max: 3.3 with no uptake in the liver (Figure 4).
Positron emission tomography scans with FDG showing an intense hypermetabolisme in the eighth dorsal vertebra and pulmonary hilar nodes (SUV max: 3.8)
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It revealed also an intense hypermetabolisme in the eighth dorsal vertebra with pulmonary hilar nodes (Figure 5).
CT scan of the pelvis showing after 3 cycles of chemotherapy a stability according to RECIST 1.1
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Evaluation after 3 cycles revealed the drop of patient's performance status to 3 versus 2 with an increase in the AFP level to 350 versus 150 ng/mL and radiologic stability according to RECIST 1.1(Figure 6).