PMC6610429_01
Postmortem histological section from liver showing confluent massive necrosis
with minimal inflammation (A). At higher power, large ground-glass nuclei
are seen (B).
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PMC6610429_01_10.1177_1179547619858979-fig1.jpg
fig1-1179547619858979
The histological sections demonstrated confluent massive necrosis with minimal inflammation (Figure 1).
Strong and diffusely positive immunohistochemical staining for HSV in
liver.
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PMC6610429_01_10.1177_1179547619858979-fig2.jpg
fig2-1179547619858979
Immunohistochemistry (IHC) for HSV showed strong and diffuse positivity (Figure 2), confirming the diagnosis of fulminant HSV hepatitis.
Focal necrosis (A), with patchy HSV-immunohistochemical positivity (B) in the
spleen.
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PMC6610429_01_10.1177_1179547619858979-fig3.jpg
fig3-1179547619858979
Focal necrosis with patchy HSV-IHC positivity was also observed in the spleen (Figure 3).