PMC5859834_01
CT scan with axial sections showing enlargement and generalized sclerosis of the cricoid cartilage. Bone window where cricoid blast transformation becomes more evident.
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fig1
A CT scan was performed which shows decreased tracheal lumen and thickening of the thyroid and cricoid cartilages (Figure 1).
A cartilage is identified with destruction by infiltration of a glandular neoplasia, with formation of small nodules with microlens as well as individually. In other fields, it presents a cribriform pattern, where the presence of large and multiple nucleoli stands out. The neoplastic cells are of medium size, polygonal, with broad vacuolated cytoplasm, with large, hyperchromatic, and pleomorphic nuclei, and with a prominent nucleus and eosinophil.
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fig2
Metastatic carcinoma with the ductal cribriform pattern was corroborated (Figure 2).
Oral cavity with a tumor of 2 cm in the right upper gingiva near to the third molar with extension to the hard palate.
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fig3
For the previous reason, palliative radiotherapy was decided as treatment to the larynx, during which the patient presented a nodule in the oral cavity in the upper right gingival area with a hard palate extension (Figure 3).
A neoplasm with an infiltration pattern is identified in small- and medium-sized nodules, surrounded by desmoplastic stroma. In some areas, minimal formation of tubular structures with low eosinophilic luminal secretion is identified. The cells that make up the neoplasia are large in size, with abundant cytoplasm, with a clear "foamy" aspect, with peripheral nuclei, and with some central, hyperchromatic, large, and regular borders.
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fig4
The biopsy reported a carcinoma with cribriform xanthomatous phenotype (Figure 4).