PMC3926371_01
Glomerular renal biopsy findings. (a) Mesangial and endocapillary hypercellularity with a lobular pattern and segmental capillary double contours (periodic acid methenamine silver x400). (b) Peripheral granular staining for C3 (x400). (c) Capillary wall subendothelial electron dense deposits with peripheral mesangial migration and new subendothelial basement membrane material forming a double contour (x19,000).
CRIM.NEPHROLOGY2014-159370.001.jpg
PMC3926371_01_CRIM.NEPHROLOGY2014-159370.001.jpg
fig1
There were no tubuloreticular structures in the cytoplasm of any cells (Figure 1).
Glomerular features of second renal biopsy. (a) Lobular hypercellular glomerulus with capillary wall double contours (periodic acid methenamine silver x600). (b) Capillary wall with subendothelial deposits and peripheral mesangial migration and interposition producing a double contour (x7200).
CRIM.NEPHROLOGY2014-159370.002.jpg
PMC3926371_01_CRIM.NEPHROLOGY2014-159370.002.jpg
fig2
A repeat kidney biopsy performed in June 2010 confirmed MPGN type I (Figure 2), with acute tubulointerstitial nephritis and mild-to-moderate chronic renal parenchymal injury.