PMC3720289_01
Histological features of a single lymph node consistent with synchronous T cell rich B cell lymphoma and Kaposi sarcoma. The lymph node architecture (A - HE, 40x) is distorted by a diffuse proliferation of large lymphoid cells intermingled with small lymphocytes and histiocytes (B and D - HE, 40x) co-existent with a proliferation of slit-like vessels, filled with red blood cells, surrounded by slightly atypical spindle cells with 12 mitoses/10 high-power fields (C and D - HE, 40x). The immunohistochemical study of the vascular lesion showed expression of CD31 and CD34 in the spindle cells (E and F - HE, 4x and 40x). In the lymphoproliferative lesion, the large lymphoid cells disclosed distinctive membrane CD20 positivity (G - HE, 4x and 40x) whereas the small lymphocytes expressed membrane CD3 positivity (H - HE, 4x and 40x).
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The immunohistochemical study of the vascular lesion showed expression of CD31 and CD34 in the atypical spindle cells (Figure 1E and 1F). CD20 positivity (Figure 1G), whereas the small lymphocytes expressed membrane CD3 positivity (Figure 1H). CD15 and CD30 were not expressed by any of the lymphoid cell types.