PMC5209397_01
a Patient timeline presenting important clinical events (m.o. = months old) and immune recovery of CD3+ CD4+ T cells over this period. b MRI brain scan showing coronal T2-weighted FLAIR (FLuid Attenuated Inversion Recovery) and axial post-contrast T1-weighted images with bilateral basal ganglia lesions (white arrows) and enhancing cortical and deep grey matter lesions (black arrows). The pattern was typical of those described in subacute panencephalitis
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Fig1
An 18-month-old male infant of consanguineous parents was diagnosed with SCID due to recombinase activating gene 1 (RAG1) deficiency (Fig. 1a) 4 months after MMR vaccination. Full donor chimerism was rapidly achieved, with recovery of a diverse T cell repertoire (Fig. 1a) and excellent thymopoiesis. Repeat MRI of the brain at 40 months post-allo-SCT revealed abnormalities of grey and white matter, involving both cerebral hemispheres with multiple foci of contrast enhancement, including the basal ganglia, temporal and parieto-occipital cortices (Fig. 1b).