PMC4498721_01
Abdominal enhanced magnetic resonance imaging with T1 findings.. Notes: (A) An 8x6 cm mass in the head of the pancreas (white arrow). (B) Liver metastasis from mixed acinar-endocrine carcinoma of the pancreas (red arrow).
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The patient eventually underwent abdominal magnetic resonance imaging, which showed an 8x6 cm mass in the head of the pancreas and showed two abnormal lesions about 2x1 cm in the liver (Figure 1).
Histopathology of the pancreas tumor.. Notes: (A) (a) Hematoxylin-eosin image of the pancreas tumor (HEX200). (b) Immunohistochemistry of trypsin (x400, Abcam). (c) Immunohistochemistry of chymotrypsin (x400, Abcam). (d) Immunohistochemistry of Ki-67 (x400, Abcam [Cambridge, MA, USA]). (B) (a) Immunohistochemistry of chromogranin A(x400, Abcam) (b) Immunohistochemistry of synaptophysin (x400, Abcam). (c) Immunohistochemistry of CD56 (x400, Abcam). (d) Immunohistochemistry of neuron-specific enolase (NSE) (x400, Abcam).
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MAEC was established (Figure 2). Microscopically, the tumor cells of liver metastasis had partly solid and partly acinar morphology.
Histopathology of the liver metastasis.. Notes: (A) (a) Hematoxylin-eosin image of the liver metastasis (HEX100). Left is adjacent cancerous tissue and right is the liver metastasis. (b) Immunohistochemistry of hepatocyte paraffin 1 (Hep Par 1) (x100, Dako). Adjacent cancerous tissue was positive for immunohistochemistry of Hep Par 1 and the liver metastasis was negative for the same. (c) The liver metastasis was negative for immunohistochemistry of Hep Par 1 (x400, Dako Denmark A/S, Glostrup, Denmark). (d) Immunohistochemistry of CD56 (x400, Abcam). (B) (a) Immunohistochemistry of trypsin (x400, Abcam), indicating that the tissue had an acinar component. (b) Immunohistochemistry of chromogranin A(x400, Abcam). (c) Immunohistochemistry of synaptophysin (x400, Abcam). (d) Immunohistochemistry of neuron-specific enolase (NSE) (x400, Abcam). Chromogranin A, synaptophysin, and NSEwere weakly positive for immunohistochemistry, suggesting that the tissue of the liver metastasis had endocrine component.
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A, and NSE (Figure 3).