PMC5461266_01
(A,B) Non-contrast MRI abdomen 1,4: hepatoblastoma (HB), 2: liver cysts, 3: enlarged polycystic and distorted kidneys, and 5: enlarged spleen. Lower panel: histological features of tumor and congenital hepatic fibrosis (CHF). (C) Liver demonstrating aberrant ductular proliferation and portal fibrosis characteristic of a bile ductal plate malformation, supporting the diagnosis of CHF. (D,E) Liver tissue representing pure fetal-type HB with low mitotic activity.
fped-05-00114-g001.jpg
PMC5461266_01_fped-05-00114-g001.jpg
F1
AFP was 1,200 ng/ml and a non-contrast MRI (secondary to impaired renal function; Figure 1) revealed a 4.6 cm x 3.9 cm heterogeneous mass in the right hepatic lobe near segment 5 with possible involvement of the caudate. Assuming the tumor to be HB with two adjacent sectors of the liver tumor-free and no lymph node or vascular involvement, it would be staged as Pretext 2. Histopathology of the resected specimen revealed pure fetal epithelial-type HB with low mitotic activity (Figure 1).