PMC6497864_01
MRI detection of brain metastasis and an MRI scan after curative radiotherapy. (A) Contrast-enhancement T1-weighted images revealed an enhanced solitary mass 19x22x25 mm in size with a surrounding area of low intensity in the right basal ganglia, associated with left frontal lobe metastases. (B) One month after curative radiotherapy, the MRI scan showed that the brain metastatic tumoral volume was significantly reduced and had disappeared.. Abbreviations: MRI, magnetic resonance imaging; T1+C, contrast-enhancement T1-weighted images; T2, T2-weighted images.
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Magnetic resonance imaging (MRI) revealed an enhanced solitary mass (19x22x25 mm) with a surrounding area of low intensity in the right basal ganglia, associated with left frontal lobe metastases (Figure 1A), and the patient was consequentially diagnosed with brain metastasis. Two months after brain radiotherapy, a follow-up MRI revealed that the cerebral metastatic tumor volumes in the right basal ganglia and left frontal lobe were significantly reduced, and the therapeutic effect was evaluated as a complete response (CR) (Figure 1B).
MRI detection of brain metastasis recurrence and MRI scanning after administration of the temozolomide regimen. (A) An MRI scan revealed an irregularly strengthened signal in the anterior corpus callosum and peripheral edema of the lesions. (B) One year after administration of the temozolomide regimen for four cycles, an MRI scan revealed that the lesions in the anterior corpus callosum had decreased, but the size of the lesions in the right lateral ventricle had significantly increased.. Abbreviations: MRI, magnetic resonance imaging; T1+C, contrast-enhancement T1-weighted images; T2, T2-weighted images.
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However, thirty-three months after the first brain radiotherapy, the patient once again complained of headache and dizziness, and a cranial MRI reexamination revealed metastatic brain tumor recurrence and progression (Figure 2A). Two months later, an MRI scan revealed slow progression of the brain tumor metastases (Figure 2B), and the patient then underwent stereotaxic radiotherapy for brain tumor metastases at the Nanfang Hospital of Nanfang Medical University (dosage not stated).
MRI scan after stereotactic radiotherapy. (A and B) After treating with mannitol and steroids to reduce intracranial pressure and to limit further damage caused by cerebral edema, an MRI scan revealed an enhanced solitary mass (53x28x20 mm) with a surrounding area of low intensity in the bilateral frontal lobe and genu of the corpus callosum.. Abbreviations: MRI, magnetic resonance imaging; T1, T1-weighted images; T2, T2-weighted images.
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An enhanced solitary mass (53x28x20 mm) with a surrounding area of low intensity was observed in the bilateral frontal lobe and genu of the corpus callosum (Figure 3A). Three months later, an MRI reexamination showed radiation encephalopathy that could not exclude brain metastases; the lesion area was not decreased after treatment (Figure 3B).
MRI scan after treating with a vascular endostatin and short-term HBO therapy. (A and B) After treating with a vascular endostatin and short-term HBO therapy, an MRI scan revealed that the clumps of matter in the bilateral frontal lobes and the genu of the corpus callosum were smaller than those on the MRI scan from 2017-07 and especially smaller than those shown on the MRI scan from 2018-06; however, the edema in the surrounding tissue was still present.. Abbreviations: MRI, magnetic resonance imaging; HBO therapy, hyperbaric oxygen therapy; T1+C, contrast-enhancement T1-weighted images; T2, T2-weighted images.
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Two and six months after Endostar treatment, MRI analysis showed that the areas of BRN and edema had decreased significantly (Figure 4A and B).