PMC10224678_01
The diagnosis of admitted patient. (A) Date of computed tomography: 2021-12-16; Red arrows indicated the change of the lesion sites; (B) Diff-quik stain, x100; (C) Gram stain, x100, the black arrow refers to clusters of Gram-positive cocci; (D) Gram stain, x100, the black arrow refers to gram-positive cocci underwent phagocytosis by polymorphonuclear leukocytes.
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Staphylococcus aureus. Specifically, a large number of centrocytes infiltrates were seen under the staining microscope with the classification count of 58.5%, which suggested suppurative infectious diseases in the lung (Figure 1B). Meanwhile, clusters of Gram-positive cocci were observed, and the morphology and distribution of which were consistent with the characteristics of Staphylococcus aureus (Figure 1C). Further, the Gram-stained smear of sputum showed that Gram-positive cocci underwent phagocytosis by polymorphonuclear leukocytes, indicating a positive cocci infection (Figure 1D).
The clinical course (temperature, WBC, CRP, PCT and IL-6) of the patient with MSSA SCAP after corresponding treatment.
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After 1 week of therapy, the patient's body temperature, infection, and inflammatory biomarkers improved (Figure 2).
Computed tomography of the patient with MSSA SCAP after corresponding treatment. (A) Date of computed tomography: 2021-12-28; (B) Date of computed tomography: 2022-1-5; (C) Date of computed tomography: 2022-1-14; Arrows indicated the change of the lesion sites.
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The lung CT showed multiple patchy shadows and the pulmonary cavity caused by infection narrows (Figure 3A). During the observation period, the patient's temperature showed a downward trend, but CT showed no obvious absorption of the pulmonary cavity (Figure 3B). On January 14, 2022 (day 31), the patient's pulmonary imaging improved significantly (Figure 3C), her body temperature decreased, and PLT returned to normal levels (Figure 4) after contezolid (800 mg every 12 h, orally) plus tazocin treatment.
The clinical course (PLT) of the patient with MSSA SCAP after corresponding treatment.
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On January 14, 2022 (day 31), the patient's pulmonary imaging improved significantly (Figure 3C), her body temperature decreased, and PLT returned to normal levels (Figure 4) after contezolid (800 mg every 12 h, orally) plus tazocin treatment.
The swallowing function of the patient before and after rehabilitation exercise. (A) Before rehabilitation exercise, the patient developed cough, the red arrow indicates that the patient has swallowing disorders, which leads to the fluid flows out and severe cough when drinking water; (B) After rehabilitation exercise, the phenomenon of bucking disappeared.
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In addition, the patient's swallowing disorder improved and the severe cough caused by intaking food or water has also disappeared after continuous rehabilitation exercise (Figure 5).
The administration process of this patient.
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The administration process was shown in Figure 6.