PMC5992337_01
Computed tomography scan (coronal view) revealing pancolitis, most severe around the cecum (circle).
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F1
Computed tomography showed pancolitis, which was most severe around the cecum (Figure 1).
Endoscopy showing multiple, medium-sized, irregular ulcers with edematous, friable mucosa and nodularity in the ascending colon, splenic flexure, sigmoid colon, and rectum (arrows).
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F2
Multiple firm masses ranging in size from 0.5 cm to 1.5 cm were noted in the ascending colon and hepatic flexure (Figure 2).
Hematoxylin and eosin staining (400x) of endoscopic biopsy specimens showing cellular tissue fragments composed of spindle cells arranged in fascicles, as well as inflammatory cells.
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F3
Examination of multiple levels of the initial biopsy specimen showed 2 cellular fragments composed of plump spindle cells arranged in fascicles with small nucleoli and increased mitosis (Figure 3).
(A) A large, smudgy cell on hematoxylin and eosin staining (400x). (B) Immunohistochemical staining for cytomegalovirus revealed positive cells with inclusion.
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F4
Infrequent large smudgy cells with cytoplasmic inclusions were noticed, and these stained positive with CMV immunostain (Figure 4).