PMC9702988_01
Light microscopy images of kidney tissue. (A) Globally sclerostic glomeruli. Silver x400. (B) Globally sclerotic glomeruli (arrow). Masson Trichrome x400. (C) Tubular atrophy (arrow) and renal interstitial fibrosis (star). Hematoxylin-eosin x200. (D) Proliferation of mesangial cells and segmental accumulation of matrix. Hematoxylin-eosin x400.
fped-10-1043502-g001.jpg
PMC9702988_01_fped-10-1043502-g001.jpg
F1
Representative findings were displayed in Figure 1.
Pedigree analysis of this family. We identified 2 brothers, the proband (III-4) and the affected brother (III-6) who were admitted to our hospital, with proteinuria. The proband was diagnosed with FSGS based on kidney biopsy. The closed boxes represent the patients with proteinuria in this family. The pedigree suggested an X-linked pattern of inheritance. Blood was collected from the proband and 5 additional family members indicated by asterisks.
fped-10-1043502-g002.jpg
PMC9702988_01_fped-10-1043502-g002.jpg
F2
The pedigree presented in Figure 2 was suggestive of an X-linked mode of inheritance.