PMC9792292_01
Pedigree of the affected family. Black color marks subjects affected by palmoplantar keratoderma, digital clubbing, and hyperhidrosis.
gr1.jpg
PMC9792292_01_gr1.jpg
fig1
IV-1 was the oldest of 3 sisters in a family with 4 children (Fig 1). However, the parents were first cousins, making a recessive mode of inheritance likely (Fig 1).
A, Severe onycholysis affecting the subject's right thumb nail. B, Notable digital clubbing. Keratoderma affecting the (C) left and (D) right palms.
gr2.jpg
PMC9792292_01_gr2.jpg
fig2
She displayed brittle hypertrophic nails with severe onycholysis and a nearly complete detachment of her left thumbnail (Fig 2).
PMC9792292_02