PMC2650718_01
Pedigree of an Indian family with autosomal dominant congenital cataract (ADCC) is shown. The proband (III:2) is indicated by an arrow. Filled squares and circles represent affected males and females, respectively. Seven members in three generations were affected with bilateral cataract since childhood. Except the proband (III:2), all other affected members (I:4, II:7, II:8, II:9, II:12, III:2, III:3) were operated for bilateral congenital cataract in the first decade of their life.
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Family history revealed seven affected members in three generations (Figure 1).
Slit lamp photograph of affected lens. A slit lamp photograph is shown of the affected lens (left eye) in the three-year-old proband (III:2, Figure 1). Cataract is of the opalescent type. The central nuclear region is more dense than the periphery.
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The phenotype in the non-operated proband (III:2) was of opalescent type with the central nuclear region denser than the periphery (Figure 2).