PMC3034992_01
FNA smear from frontal mass showing single and loosely clustered Langerhans cells admixed with neutrophils, lymphocytes and, reactive histiocytes. Two foamy macrophages containing hemosiderin are seen in the centre (Papanicolaou stain, original magnification, x400).
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fig1
These were admixed with a polymorphic population of eosinophils, neutrophils, lymphocytes, plasma cells, foamy histiocytes, and multinucleated reactive histiocytic giant cells (Figure 1). They also contained hemosiderin in smears from skull masses (Figure 1).
Langerhans cells with moderate to abundant cytoplasm and prominent nuclear grooves (Papanicolaou stain, original magnification, x400).
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fig2
Prominent nuclear indentations and grooves (with a coffee bean appearance) were observed which were best seen in Papanicolaou stain (Figure 2).
(a) Extracellular rhomboid Charcot-Leyden crystals (Papanicolaou stain, original magnification, x400). (b) Macrophages with several ingested Charcot-Leyden crystals (Papanicolaou stain, original magnification, x400).
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fig3
In addition, many rhomboid and needle-shaped Charcot-Leyden crystals were seen both extracellular (Figure 3(a)) and intracellular in the giant cells (Figure 3(b)).