PMC3045764_01
Features of fibrolamellar variant of hepatocellular carcinoma seen in the fine needle aspirate material. Diff Quik-stained smears (a and b) show large discohesive tumor cells with abundant granular cytoplasm and low nuclear to cytoplasmic ratios. A well-defined cytoplasmic pale body is seen in a. Papanicolaou-stained smears (c and d) demonstrate prominent nucleoli and naked nuclei. An intranuclear pseudoinclusion is also seen in d
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F1
Air-dried, Diff Quik-stained slides and alcohol-fixed smears were prepared and the Diff Quik-stained slides [Figure 1] were examined on-site.
Low-power view of fibrolamellar variant of hepatocellular carcinoma (hematoxylin and eosin [H and E]), with cords of tumor cells separated by bands of fibrous tissue. The inset shows a higher power image (H and E), which better demonstrates the abundant eosinophilic granular cytoplasm, cytoplasmic pale bodies and nuclei with prominent nucleoli
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F2
Later, cells from the FNA sample were compared with the previously resected liver tumor that had revealed FL-HCC [Figure 2].