PMC7475169_01
CT scan image showing an Adrenal "Incidentaloma".
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Surgical specimen showing a yellowish-white solid neoplastic lesion with a smooth homogeneous external capsule.
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H& E slides showing proliferation of fusiform cells arranged in interlocking bundles, a predominantly collagenous stroma with myxoid degeneration and inflammatory cells; the proliferating cells showed minimal pleomorphism, elongated nuclei with a regular contour, homogeneous chromatin and isolated inconspicuous nucleoli, without the presence of a significant number of mitosis figures (< 1 mitosis for every 10-40X fields). No areas of necrosis within the lesion were identified. Scarce adrenal tissue was identified in the periphery of the lesion.
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Scarce adrenal tissue was identified in the periphery of the lesion (Fig. 3).
Immunochemistry showing diffuse and intense positivity for S-100, SOX-10 and CD34.Staining was negative for STAT-6 (fibrous tumor), CD117 (gastrointestinal stroma) and smooth muscle actin (leiomyoma). Ki67 proliferation index was 1%.
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These findings correspond to a benign nerve sheath tumor, or Schwannoma (Fig. 4).