PMC6503774_01
Clinical. (a) A 55-year-old female with swelling in the right parasymphysis region. (b) Swelling extending from 43 to 46 region. H/O extraction of 44 and 45 2 years ago. (c) Ill-defined radiolucency extending from 43 to mesial aspect of 47 causing thinning of lower border of the mandible
JOMFP-23-140-g001.jpg
PMC6503774_01_JOMFP-23-140-g001.jpg
F1
Periphery of the lesion was partly corticated [Figure 1]. Finally, diagnosis of CCOC was established [Figure 3 and Table 1].
Histopathological. (a) Incisional biopsy indicated that the tumor was composed of irregularly outlined lobules with intervening thick fibrovascular septa (H&E, x40). (b) On higher magnification, the lobules were composed of a biphasic population of cells - round to oval cells with eccentric nucleus and clear cytoplasm and another group of polygonal cells with hyperchromatic nucleus and eosinophilic cytoplasm (H&E, x100). (c) Cells were seen invading the fibrous septa (H&E, x400)
JOMFP-23-140-g002.jpg
PMC6503774_01_JOMFP-23-140-g002.jpg
F2
Under higher magnification, biphasic population of cells was evident - a population of large cells with eccentric nucleus and clear cytoplasm as well as polygonal cells with hyperchromatic nucleus and eosinophilic cytoplasm [Figure 2].
Immunohistochemical analysis. (a) Tumor cells were positive for CK19 (x400). (b) Negative for CK17 (x400). (c) Negative for carcinoembryonic antigen (x400). (d) Ki67 >10% positivity (x400)
JOMFP-23-140-g003.jpg
PMC6503774_01_JOMFP-23-140-g003.jpg
F3
Finally, diagnosis of CCOC was established [Figure 3 and Table 1].