PMC9268333_01
gross photographs of SCD patients with COVID-19 at autopsy (37 Military Hospital, Accra, Ghana, September 2020 to January 2021); A) autosplenectomy with pigment gall stones; B) regenerative nodules of extramedullary haematopoises in spleen (white arrows); C) thinning of cortical bone of skull with bone resorption (green arrow)
PAMJ-41-332-g001.jpg
PMC9268333_02_PAMJ-41-332-g001.jpg
F1
The spleen weighed 19g, was small, measuring 7x3.5x1.5cm, appeared fibrotic and few dark brown regenerative nodules were noted on cut surface (Figure 1B). There was thinning of the cortical bones of the skull with bone resorption (Figure 1C).
haematoxylin & Eosin (H&E) staining of various tissues of SCD patients with COVID-19 (37 Military Hospital, Accra, Ghana, September 2020 to January 2021); A) advanced autosplenectomy with calcified siderofibrotic nodules (red arrows) X 100; B) liver sinusoids (green arrow) with erythrophagocytosis of RBCs (red arrow) and extramedullary haemopoiesis (blue arrow) X 100; C) normal (blue arrow) and fibrosed glomerulus (green arrow) X 100; D) sidero-fibrotic nodules (red arrow) interspersed with vessels containing sickled RBCs (blue arrow) X 100
PAMJ-41-332-g002.jpg
PMC9268333_02_PAMJ-41-332-g002.jpg
F2
Histopathology of the lungs showed DAD with extensive HM bilaterally (Figure 2E and Figure 2F). The spleen showed sidero-fibrotic nodules interspersed with vessels containing sickled RBCs (Figure 2D).
PMC9268333_02
gross photographs of SCD patients with COVID-19 at autopsy (37 Military Hospital, Accra, Ghana, September 2020 to January 2021); A) autosplenectomy with pigment gall stones; B) regenerative nodules of extramedullary haematopoises in spleen (white arrows); C) thinning of cortical bone of skull with bone resorption (green arrow)
PAMJ-41-332-g001.jpg
PMC9268333_02_PAMJ-41-332-g001.jpg
F1
The spleen weighed 19g, was small, measuring 7x3.5x1.5cm, appeared fibrotic and few dark brown regenerative nodules were noted on cut surface (Figure 1B). There was thinning of the cortical bones of the skull with bone resorption (Figure 1C).
haematoxylin & Eosin (H&E) staining of various tissues of SCD patients with COVID-19 (37 Military Hospital, Accra, Ghana, September 2020 to January 2021); A) advanced autosplenectomy with calcified siderofibrotic nodules (red arrows) X 100; B) liver sinusoids (green arrow) with erythrophagocytosis of RBCs (red arrow) and extramedullary haemopoiesis (blue arrow) X 100; C) normal (blue arrow) and fibrosed glomerulus (green arrow) X 100; D) sidero-fibrotic nodules (red arrow) interspersed with vessels containing sickled RBCs (blue arrow) X 100
PAMJ-41-332-g002.jpg
PMC9268333_02_PAMJ-41-332-g002.jpg
F2
Histopathology of the lungs showed DAD with extensive HM bilaterally (Figure 2E and Figure 2F). The spleen showed sidero-fibrotic nodules interspersed with vessels containing sickled RBCs (Figure 2D).
haematoxylin and Eosin (H&E) staining showing extramedullary haemopoiesis in the spleen (37 Military Hospital, Accra, Ghana, September 2020 to January 2021); A) Junction between sidero-fibrotic nodule (red arrow) and haemopoietic cells (green arrow) X100; B) myeloid precursor (red arrow), erythroid precursors (green arrow) and sidero-fibrotic area (blue arrow) X400; C) erythroblasts at various stages of differentiation (green arrows), neutrophil band cell (red arrow) and a mature neutrophil (white arrow) X400; D) myeloid precursors (red arrows) and erythroid precursors (white arrow) X400; E) erythroid precursors (red arrows) and a megakaryocyte (white arrow) X400; F) sickled red blood cells (green arrows) and erythroid precursors (red arrow) X400
PAMJ-41-332-g003.jpg
PMC9268333_02_PAMJ-41-332-g003.jpg
F3
Areas of extramedullary haemopoiesis were noted in the regenerative nodules of the spleen on histology revealing erythroid and myeloid precursors, megakaryocytes in a pool of sickled RBCs (Figure 3).
PMC9268333_03