PMC9561615_01
Sleep raster plot showing sleep timing (sleep onset, duration, and wake-up time) as measured with an electronic sleep diary over a period of 70 days in the carrier of the rs143641898 OPN4 variant. The raster plot confirms consistently delayed sleep onset captured over more than 10 weeks of a sleep diary.
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F1
The patient has been enrolled in a 12-week diary study (Figure 1 raster plot below).
Salivary melatonin DLMO in the carrier of the rs143641898 OPN4 variant. The DLMO is significantly later than that of population controls, in this example, occurring at 23:17.
fgene-13-896192-g002.jpg
PMC9561615_01_fgene-13-896192-g002.jpg
F2
Confirmatory of the delayed phenotype is also the timing of the dim light melatonin onset (DLMO) occurring at 23:20 (quantified with the salivary melatonin assay) presented in Figure 2.