PMC10150764_01
(A) Bone marrow examination. The bone marrow smear showed active hyperplasia. Magnification: x100. (B) Peroxidase stain for bone marrow smear. Magnification: x100. (C) Flow cytometric immunophenotyping of bone marrow.
PGPM-16-401-g0001.jpg
PMC10150764_01_PGPM-16-401-g0001.jpg
f0001
Bone marrow smear indicated active bone marrow hyperplasia, and we observed 46.5% of protogranulocytes (small and unequal in size and some cytoplasm containing a few azurophilic granules), many basophilic erythroblast, megakaryocytes and small megakaryocytes, but little immature lymphocytes (Figure 1A). AML-M2 (Figure 1B). As shown in Figure 1C, abnormal myeloid primordial cells were found in the specimens, accounting for 32.86% of the nuclear cells, which was in line with AML phenotype.
Cytogenetic analysis of bone marrow.
PGPM-16-401-g0002.jpg
PMC10150764_01_PGPM-16-401-g0002.jpg
f0002
Moreover, the patient's karyotype was 44, X,-Y,del(5)(q31),-7add(12)(p13)der(17)der(18), 22,+mar([8]/44,idem,del(4)(q22)[12] (Figure 2).