PMC3268173_01
Case 1. Fundus photographs of case 1. (A,B) At presentation, bilateral severe disc edema and vascular tortuosity were observed. (C,D) Three weeks after administration of methotrexate, disc edema and vascular tortuosity were resolved.
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F1
After 3 weeks of methotrexate, the disc edema and ocular inflammation were alleviated, and his vision improved to 20 / 20 in both eyes (Fig. 1A and 1B). However, a daily low-to-moderate dose of prednisolone (10-20 mg) combined with a weekly dose of methotrexate 15 mg (0.26 mg/kg) alleviated the ocular inflammation and disc edema (Fig. 1C and 1D).
PMC3268173_02
Case 2. A fundus photograph (A) and fluorescein angiography (B) of the right eye revealing disc edema and choroiditis. (C,D). One month after administration of methotrexate, the disc edema and fluorescein leakage from the optic disc were resolved.
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F2
A 15-year-old female patient presented with optic disc edema in the right eye and bilateral idiopathic panuveitis (Fig. 2A and 2B) with no associated neurologic or systemic abnormalities. The disc edema resolved dramatically one month after the initiation of methotrexate (Fig. 2C and 2D).