PMC6567292_01
Patient's pedigree.
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His parents had two children and the family history of the patient was remarkable for a deceased brother at the age of 15 years, who had also ID ( Figure 1).
Image of the patient's chromosomes.. 
a) Patient's GTG banded karyotype,
b) Schematic of normal and derivative chromosomes 2 and 18 and breakpoints regions of chromosomes.
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Conventional cytogenetic analysis revealed that the patient had an insertional translocation: 46, XY, inv ins(18;2)(q11.2;q13q22) ( Figure 2).
Array-based comparative genomic hybridization chromosomal ideogram and clustering of breakpoints.
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Array CGH did not show any deletion or duplication ( Figure 3).