PMC10155007_01
Pupil constriction 60 mins in the right eye post-0.05% pilocarpine, suggestive of
dysautonomia. Pilocarpine was not applied to the left eye as a control
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A pilocarpine (0.05%) response test showed pupil constriction at 60 mins (Figure 1) and histamine intradermal testing performed by intradermal 0.05 ml injections of histamine (1:10,000) and 0.9% saline and showed no response to histamine.
PMC10155007_02
Esophagus and stomach in a 7-month-old male Russian Blue cross kitten. The esophagus
(which is on the left) is markedly dilated and thinned, with inversion of the stomach
into the distal aspect. The gastric rugae are visible with scant tan mucus adhered to
the mucosa. On cut section the gastric submucosa is expanded by 4 mm of diffuse edema. A
significant portion of the greater omentum is also present within the esophagus
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Post-mortem examination revealed a markedly dilated and thinned esophagus with approximately 90% of the stomach and greater omentum inverted into the distal esophagus; however, no evidence of hiatal hernia was present on necropsy (Figure 2).
(a) Celiac ganglion (hematoxylin and eosin) staining in a 7-month-old male kitten with
dysautonomia. There is marked neuronal dropout and remaining ganglion are frequently
necrotic, characterized by shrunken borders, cytoplasmic hypereosinophilia and pyknotic
nuclei, or degenerate, characterized by cytoplasmic vacuolation and central
chromatolysis. Ganglion are also frequently flanked by glial cells (satellitosis). (b)
Celiac ganglion (hematoxylin and eosin) in a 1-year-old cat (non-age-matched) with
normal neuronal density and no microscopic abnormalities
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Special stains including glial fibrillary acidic protein, and neurofilament protein highlighted neuronal dropout and were compared with a 1-year-old healthy cat as a non-age-matched control (Figures 3 and 4).
(a) Celiac ganglion (glial fibrillary acidic protein [GFAP]) staining in a 7-month-old
male Russian Blue cross kitten with dysautonomia. There is a marked decrease in
immunoreactivity highlighting neuronal dropout. (b) Celiac ganglion (GFAP) in 1-year-old
cat (not age-matched) with normal neuronal density and no microscopic abnormalities
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Special stains including glial fibrillary acidic protein, and neurofilament protein highlighted neuronal dropout and were compared with a 1-year-old healthy cat as a non-age-matched control (Figures 3 and 4).