PMC3431056_01
Pelvic CT showing diffuesly thickened bladder wall.
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Repeat PET CT scan at that time showed lesions in liver, peritoneal carcinomatosis, and right-sided hydronephrosis extending into the ureter down to the diffusely thickened bladder (Figure 1).
(a) Benign bladder mucosa (top) with diffusely infiltrating malignant cells in the lamina propria (Hematoxylin and eosin stain x100). (b) Discohesive and loosely clustered malignant cells in an edematous stroma (Hematoxylin and eosin stain x200). (c) The malignant cells closely resemble plasma cells with eccentric nuclei and moderate to abundant eosinophilic cytoplasms. Prominent retraction artefacts and few cells with cytoplasmic vacuoles (center) are also seen (Hematoxylin and eosin stain x400). (d) E-Cadhedrin staining. Normally, the positivity is strong and diffuse like in the normal urothelial mucosa in the picture (bottom). It is markedly diminished in the tumor cells (upper part).
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Prominent pericellular retraction artefacts and edematous stroma were also present (Figure 2). E-Cadherin immunostain was markedly diminished (Figure 2).