PMC5961131_01
MRI of the spine at the level of L4/L5. Transverse T1 W (A) and T1 W post contrast (B) are shown. On the post contrast image there is dense, homogenous enhancement of the abnormal meninges (arrow) and, due to the severe meningeal thickening, there is circumferential compression of the spinal cord.
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F1
The abnormal meninges were homogenous in appearance and intermediate in signal on T2W images. T1W post contrast images revealed a dense, homogenous enhancement of the abnormal meninges at the level of L4 (Fig. 1).
Magnetic resonance imaging (MRI) study at the level of L3 on a T2W sequence, transverse view. Note the enlarged right lumbar aortic lymph node (arrow), which was later sampled and cytology found to be consistent with a large granular lymphocyte lymphoma.
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F2
Within the abdomen, a lesion consistent with enlargement of the right lumbar aortic lymph node was identified (Fig. 2).
Fine-needle aspirates from a lymph node of a dog with a large granular lymphocyte lymphoma. A, B: monomorphic population of large lymphoid cells. Mitoses are frequently observed (B: green arrows). Low numbers of tingible body macrophages are present (B: black arrow). Wright-Giemsa, 20X (A), 50X (B).
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F3
Cytology was consistent with a high grade lymphoma with a large granular lymphocyte (LGL) morphology identified on samples of the lymph node (Fig. 3, 4) and spleen (Fig. 5); flow cytometry was not diagnostic due to the poor cell preservation, whilst PCR for antigen receptor gene rearrangements (PARR) was positive for a clonal T-cell receptor rearrangement, confirming a T- cell lymphoma.
Fine-needle aspirates from a lymph node of a dog with a large granular lymphocyte lymphoma. Monomorphic population of large lymphoid cells, some of which contain variable numbers of fine azurophilic intracytoplasmic granules (black arrows). Wright Giemsa, 100X.
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F4
Cytology was consistent with a high grade lymphoma with a large granular lymphocyte (LGL) morphology identified on samples of the lymph node (Fig. 3, 4) and spleen (Fig. 5); flow cytometry was not diagnostic due to the poor cell preservation, whilst PCR for antigen receptor gene rearrangements (PARR) was positive for a clonal T-cell receptor rearrangement, confirming a T- cell lymphoma.