PMC8597774_01
A - Light microscopy showing enlarged and hyperchromatic nuclei in some tubules (H and E x200); B - The glomeruli exhibiting podocyte hyperplasia (Jones methenamine silver satin, 200X); C - Electron microscopy showing diffuse foot process effacement with microvillous transformation.
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Electron microscopy was notable for widespread podocyte foot process fusion (95-100%) and focal microvillous transformation (Figure 1C).
PMC8597774_02
A - Light microscopy showing enlarged and hyperchromatic nuclei in some proximal tubules (H&E,100X); B - Jones methenamine silver satin showing collapse of capillary lumen and hyperplasia of podocytes (200x); C - Electron microscopy showing effacement of foot processes in the cytoplasm of podocytes and resorption granules.
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Diffuse tubular alteration and edema were also noted, revealing multiple foci of tubules with enlarged and hyperchromatic nuclei, along with patchy to diffuse interstitial inflammation (Figure 2A and B). Electron microscopy showed extensive widespread podocyte foot process fusion (100%) (Figure 2C).