PMC10187600_01
(a) Craniocaudal (CC) view mammogram of the left breast shows heterogeneous dense breast parenchyma and mass not visualized on this view. (b) Mediolateral oblique view mammogram shows well circumscribed mass in central posterior breast. The left axilla shows enlarged lymph nodes.
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F1
The left axilla showed enlarged lymph nodes. [Figure 1a and b] Ultrasonography demonstrated a circumscribed hypoechoic mass of 1.7 cm in the middle outer quadrant.
(a and b) Hematoxylin-eosin [H-E] stain shows complete effacement of lymph node architecture by neoplastic follicles composed of mixture of centrocytes and centroblasts. There is lack of tangible body macrophages and attenuated mantle zones
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F2
Microscopic examination of breast lumpectomy and axillary lump excision revealed lymph nodes with neoplastic follicles comprising of atypical small lymphoid cells and approximately 8-9 centroblasts in a high-power field [Figure 2a and b].
(a) Immunohistochemical (IHC) staining revealed the expression of CD20 by neoplastic B lymphocytes (magnification x20), (b) IHC staining with BCL2 highlights neoplastic B lymphocytes (magnification x20)
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F3
Immunophenotypic analysis was performed on paraffin-embedded tissue sections and a strong positive stain for CD20, CD10, BCL2 and BCL6 antibodies was demonstrated [Figure 3a and b].