PMC8101650_01
A - A tumor comprised of clear cells arranged in clusters. The cells have abundant clear-to-vacuolated cytoplasm and a central round nucleus showing mild pleomorphism. Nucleoli are inconspicuous (H&E 400X). B - Tumor cells showing strong membranous staining with RCC antigen (400X). C - Tumor cells showing strong membranous staining with vimentin. D - Tumor cells showing no staining with SMA (400X). RCC = renal cell carcinoma; SMA = smooth muscle actin.
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No distinct cell borders, cell membrane thickening, or any raisin-like nuclei were seen (Figure 1A). On immunohistochemical examination, the tumor cells were strongly positive for RCC antigen (Figure 1B), vimentin (Figure 1C), panCK and EMA (Figure 1D), but showed negativity for smooth muscle actin, CD34, CD 31, CD10, HMB-45, and S-100, PAX-8 and CK 7.