PMC8192865_01
The bone marrow biopsy shows hypercellularity (>90%) by mononuclear, immature cells. Flow cytometry demonstrated a B cell lymphoblastic leukemia.
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PMC8192865_01_gr1.jpg
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Pathology evaluation, flow cytometry, and cytogenetic studies A bone marrow biopsy was performed, showed a hypercellular (>90%) bone marrow occupied by >90% of medium to large sized blasts with dispersed chromatin, inconspicuous nucleoli, and scant cytoplasm (see Fig. 1, Fig. 2).
A shows the karyotype of one clone with inv(7)(p15q34) and +mar[cp8]. B shows four separate chromosomes from different cells with the inv(7) and a normal chromosome for comparison.
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At least two cells contained the following alterations: 1) A pericentric inversion of chromosome 7 in which breakage and reunion have occurred at bands 7p15 and 7q34 (see Figs. 3A and 3B). 2) Monosomy of chromosome 15. 3) A marker chromosome of unknown origin.