PMC3592509_01
Clinical course of Positive and Negative Syndrome Scale (PANSS) scores and plasma concentrations of paliperidone (PAL) after switching from risperidone (RIS) to PAL.. Abbreviations: Positive, positive scale; Negative, negative scale; General, general psychopathological scale.
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The patient's dose was increased to 6 mg/day but his mental condition remained unchanged (PANSS score of 82). The dose was then increased to 12 mg/day and after this there was no evidence of psychotic symptoms. The patient's mental condition was maintained over 12 months with 12 mg/day without any adverse effects, and his PANSS scores ranged from 44 to 52 (Figure 1).