PMC5028866_01
(a) Photomicrograph demonstrating significant pleomorphism and variable dimension of rhabdomyoblastic cells with abundant eosinophilic cytoplasm and eccentric nuclei (HE x400). (b) The neoplastic cells showing strong desmin positivity by immunohistochemical reaction (desmin x400). (c) The neoplastic cells with nuclear staining for myogenin (myogenin x400).
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fig1
A histopathological diagnosis of pleomorphic rhabdomyosarcoma was made based on the detection of fused cells of variable dimensions with eosinophilic cytoplasm, which were irregular and hyperchromic (see Figure 1(a)). The neoplastic cells expressed desmin (see Figure 1(b)), actin, and myogenin (see Figure 1(c)) in immunohistochemical testing, confirming the diagnosis of rhabdomyosarcoma.
Macroscopic section of the total laryngectomy specimen showing the solid tumoral lesion in the left vocal cord.
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fig2
T3N0M0 (stage III) glottic cancer. The patient underwent total laryngectomy (see Figure 2) and left radical neck dissection with an uneventful postoperative recovery.