PMC3339687_01
a On admission painful erythematous plaques were observed on the upper medial thighs bilaterally. b After seven months of treatment with bexarotene and prednisone, infiltration and reddening of the skin were no longer present, leaving atrophy of the subcutaneous tissue.
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F1
A 63-year-old woman presented with painful subcutaneous nodules bilaterally on her upper thighs (fig. 1a). Clinically, a rapid improvement was observed after initiation of treatment (fig. 1b).
a, b H&E staining of lesional skin reveals dense lymphocytic infiltration of adipose tissue with classical rimming of atypical lymphocytes around adipocytes. c, d The infiltrates were determined to be cytotoxic lymphocytes with positive immunohistochemical staining for CD3 and CD8, respectively.
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F2
CD3, CD8 (fig. 2c, d), perforin, TIA-1, and negatively for CD4, CD5, CD56. Complete staging, including CT of thorax and abdomen and head MRI revealed no systemic involvement.