PMC3896856_01
The tumor was elastic and soft with a relatively clear border, and located in the medial aspect of the left thigh.
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F1
A well-demarcated elastic soft mass (size, 7x6cm) was palpable in the medial aspect of the left thigh (Figure 1).
Magnetic resonance imaging of the tumors. (A) A T2-weighted coronal magnetic resonance imaging scan showed two soft-tissue tumors in the intramuscular layer between the vastus medialis muscle and the adductor muscle. Extensive peritumoral inflammatory edema was obvious. (B) A T1-weighted axial magnetic resonance imaging scan of the distal tumor (size, 4.0 x 4.0 x 3.5cm) showed homogeneous low signal intensity. (C) A T2-weighted axial magnetic resonance imaging scan showed heterogeneous low and high combined intensities.
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F2
Magnetic resonance imaging (MRI) scans revealed two soft-tissue tumors in the intramuscular layer between the vastus medialis muscle and the adductor muscle (Figure 2A). T2-weighted axial imaging (Figure 2C) revealed heterogeneous low and high combined intensities. The proximal tumor (size, 2.0x2.0x1.5cm), located 9cm proximal to the distal tumor, had the same intensity on the MRI scan (Figure 2A).
Histological examination of the tumor. (A) Histological examination of the biopsy sample showed dense infiltration of large, atypical, pleomorphic spindle cells with prominent nucleoli and mitotic figures. (B, C) Immunohistochemical examination revealed that the atypical cells were positive for CD30 (B), but negative for anaplastic lymphoma kinase (C).
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F3
Histological examination of the biopsy sample showed dense infiltration of large, atypical, pleomorphic spindle cells with prominent nucleoli and mitotic figures (Figure 3A, hematoxylin and eosin (H&E) stain, x40). Immunohistochemical examination revealed that the atypical cells were positive for CD3, CD30 (Figure 3B, x40), CD45, and CD45RO but negative for CD20, CD34, and ALK (Figure 3C, x40).