PMC2225466_01
Findings at endoscopy. Note the large ulcerative gastric mass on the
greater curve of the stomach.
SRCM2007-82012.001.jpg
PMC2225466_01_SRCM2007-82012.001.jpg
fig1
Endoscopy showed a large focally ulcerative gastric mass on the greater curve with prominent underlying vasculature (see Figure 1).
Photomicrograph (x200) of the original
resection specimen showing a cellular and epithelioid neoplasm.
SRCM2007-82012.002.jpg
PMC2225466_01_SRCM2007-82012.002.jpg
fig2
S100 protein, chromogranin and synaptophysin were negative, therefore supporting the morphological diagnosis of GIST (see Figure 2). Surgical excision was complete and he made a good recovery.
Computerised tomography scan of large
abdominal mass measuring 20 x 11 x 25 cm.
SRCM2007-82012.003.jpg
PMC2225466_01_SRCM2007-82012.003.jpg
fig3
Computerised tomography (CT) scan demonstrated a large abdominal mass involving the mesentery and abdominal wall musculature measuring 20 x 11 x 25 cm (see Figure 3).
Photomicrograph (x200) of representative area of tumour at post mortem. Note the small pyknotic nuclei and areas of amorphous myxoid stroma representing areas where
the tumour cells have disappeared. Other
areas were virtually
acellular.
SRCM2007-82012.004.jpg
PMC2225466_01_SRCM2007-82012.004.jpg
fig4
Histologically, the vast majority of the main mass was hypocellular consisting of scattered tumour cells staining positive with CD117 with pyknotic nuclei and condensed cytoplasm (resembling mast cells) in an abundant myxoid stroma (see Figure 4).
(a) Photomicrograph of representative area of tumour at resection 
and (b) at post mortem stained with
CD31, an endothelial marker
SRCM2007-82012.005.jpg
PMC2225466_01_SRCM2007-82012.005.jpg
fig5
The vessel density appeared similar, but in the autopsy slides the vessels, although of the same delicate calibre, are significantly more dilated (see Figure 5).