PMC5463174_01
Microscopy of gastric tumor on biopsy.
CRIPA2017-9871687.001.jpg
PMC5463174_01_CRIPA2017-9871687.001.jpg
fig1
They were classified into well-differentiated and moderately differentiated tubular adenocarcinoma (tub1 and tub2) based on JGCA 2010 Classification of Gastric Carcinoma (6) (Figure 1). Tumors of the Digestive System (Figure 1). Therefore, the pathological diagnosis was considered as gastric mixed adenoneuroendocrine carcinomas (MANEC) as stated in WHO 2010 Classification.
Immunoprofile of gastric tumor performed on biopsy.
CRIPA2017-9871687.002.jpg
PMC5463174_01_CRIPA2017-9871687.002.jpg
fig2
It was then confirmed by immunostaining with neuroendocrine component positive for synaptophysin (3+), chromogranin A (3+), and CD56 (2+) (Table 2; Figure 2). The result was HER2 (3+) only in adenocarcinoma component and Ki67 labelling index is strongly positive (Table 2; Figure 2).
Microscopy of gastric tumor on autopsy.
CRIPA2017-9871687.003.jpg
PMC5463174_01_CRIPA2017-9871687.003.jpg
fig3
Adenocarcinoma was not detected in the metastatic lesions and liver failure, due to metastasis of NEC, was the cause of death (Figures 3, 4, and 5).
Immunoprofile of gastric tumor performed on autopsy.
CRIPA2017-9871687.004.jpg
PMC5463174_01_CRIPA2017-9871687.004.jpg
fig4
Adenocarcinoma was not detected in the metastatic lesions and liver failure, due to metastasis of NEC, was the cause of death (Figures 3, 4, and 5).
Immunoprofile of liver lesion performed on autopsy.
CRIPA2017-9871687.005.jpg
PMC5463174_01_CRIPA2017-9871687.005.jpg
fig5
Adenocarcinoma was not detected in the metastatic lesions and liver failure, due to metastasis of NEC, was the cause of death (Figures 3, 4, and 5).