PMC8724312_01
Typical neonatal rash on the infant's skin.
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F1
A 4-month-old female infant with a birth weight of 2,400 g and a gestational age (GA) of 37+1 weeks was diagnosed with IP by typical neonatal rash and truncal hyperpigmentation (Figure 1).
The first exam of fundus photography and fluorescein angiography image showed incomplete peripheral vascularization, retina neovascularization, foveal hypoplasia, and fluorecsein leakage.
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F2
III wide-angle fundus imaging system (Clarity Medicla Systems, Pleasanton, CA, USA), showed incomplete peripheral vascularization, retina neovascularization, foveal hypoplasia, and fluorescein leakage in both eyes, which were more pronounced in the left eye (Figure 2). Intravitreal injection with 0.25 mg conbercept (Lumitin  Chengdu Kanghong Biotech Co, Ltd, Chengdu, China) was administered to each eye after obtaining informed consent from her parents.
Two weeks after the first intravitreal injection of conbercept, the fundus photography showed mild hemorrhage (white arrow) on the peripheral retina in the right eye and cotton-wool spots (black arrow) near the macular in the left eye. Fluorescein angiography showed the enlargement of the non-perfused region of the retina in the left eye and the regression of neovascularization in both eyes.
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F3
The peripheral non-perfusion and neovascularization in the right eye remained unchanged (Figure 3).
One month after the first intravitreal injection of conbercept, the fundus photograph showed the absorption of the cotton-wool spots and the fluorescein angiography showed regression of neovascularization.
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F4
Another session of 532 nm laser photocoagulation with 238 spots to the inferior ischemic retina near the posterior pole was performed on the left eye (Figure 4).
Two months after the first intravitreal injection of conbercept, the fundus examination showed the disappearance of the cotton-wool spots in the left eye, and the fluorescein angiography showed further regression of neovascularization in the right eye.
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F5
Additional 532 nm laser treatment was applied to the remaining inferior temporal avascular retina of the left eye (Figure 5).
Eight months after the first intravitreal injection of conbercept, the fundus examination showed some blood vessels grew into the laser spot region of the retina, and the fluorescein angiography showed some activation of neovascularization in the left eye. There was no significant change in the right eye. About 100 laser photocoagulation spots then could be seen in the avascular area of the right eye.
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F6
The OCT showed that the fovea of the left eye was thinner than that of the right eye, especially the temporal macula (Figure 6).