PMC3517835_01
(a) Prostatic needle core biopsies show Gleason's grade 4 prostatic adenocarcinoma. (hematoxylin-eosin stain, x200). (b) The gastric biopsy reveals infiltration of the neoplastic cells with round nuclei and abundant eosinophilic to amphophilic cytoplasm. (hematoxylin-eosin stain, x200). (c) The neoplastic cells strongly immunoreactive for PSA (Immunohistochemical stain for PSA, x200). (d) The neoplastic cells strongly immunoreactive for PSAP (immunohistochemical stain for PSAP, x200).
CRIM.ONCMED2012-292140.001.jpg
PMC3517835_01_CRIM.ONCMED2012-292140.001.jpg
fig1
T8 and T11) and the left iliac bone and femur. Thorax and abdominopelvic CT scans were normal for other metastases. The prostate biopsy was performed and histopathology confirmed an adenocarcinoma of prostate, with a Gleason score of 7 (3 + 4) (Figure 1(a)). Histopathological examination of endoscopic biopsies showed an infiltration of the neoplastic cells with round nuclei and abundant eosinophilic to amphophilic cytoplasm (Figure 1(b)). Immunohistochemically the neoplastic cells were positive for PSA (prostate-specific antigen) and PSAP (prostatic-specific acid phosphatase) and negative for cytokeratin 7 and cytokeratin 20 (Figures 1(c) and 1(d)).