PMC442117_01
Treatment course of case 2 (Patient 2).
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Treatment course (Fig. 2): Since the symptoms were severe at the initial examination (Fig. 3), we recommended the use of relatively strong topical steroids, but the patient had a fear of strong steroids, and thus did not agree to their use other than hydrocortisone ointment (containing oxytetracycline hydrochloride).
Sixteen months after the initial examination the patient showed no exanthema (Patient 2).
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Later, Kami-shoyo-san (Jia-wei-xiao-yao-san) (Table 8) extract preparation, which is also used for treatment of psychosomatic disease, was added to the combination and the symptoms were markedly improved (Fig. 4).
Treatment course of case 3 (Patient 3).
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Treatment course (Fig. 5): Treatment began with topical steroids (alclometasone dipropionate ointment and prednisolone valerate acetate ointment for face, and diflucortolone valerate ointment and mometasone furoate cream for body) and oral anti-allergic drug (terfenadine).
PMC442117_02
Treatment course of case 4 (Patient 4).
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Six months after the initial examination exanthema disappeared (Patient 4).
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Exanthema disappeared 1 month after initiation of Hochu-ekki-to administration, and the patient became aware of mental calmness (Fig. 8).
PMC442117_03
Treatment course of case 5 (Patient 5).
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Treatment course (Fig. 9): Because of the severe skin symptoms at the initial examination (Fig. 10), topical steroids were recommended, and the patient was instructed to apply prednisolone valerate acetate ointment to the face and difluprednate to the body, which were confirmed to give no stimulation or aggravation by external application test.
Four months after the initial examination exanthema was absent (Patient 5).
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Erythema remitted to a fair degree after two months (Fig. 11), and exanthema was absent after 4 months.
Treatment course of case 6 (Patient 6).
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Treatment course (Fig. 12): Oral administration of Byakko-ka-ninjin-to (Bai-hu-jia-ren-shen-tang) (Table 4) extract, 9 g/day, which had been prescribed by the previous physician, was continued, and an anti-allergic agent, oral epinastine hydrochloride was administered.