PMC10062526_01
Timeline of clinical events recorded in the proband. IVF, in vitro fertilization; IVM, :in vitro maturation; vEDS, :vascular Ehlers-Danlos syndrome; PGD, :pre-implantation genetic diagnosis. Implantation and births via surrogate.
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F1
At age 41, another implantation was successful with the same surrogate; her daughter was born and confirmed to be negative for the familial COL3A1 variant during prenatal and postnatal genetic testing (Figure 1).