PMC10391646_01
Chemodectoma in the heart of a domestic short-hair cat. The neoplasm effaced the right and left atria, atrioventricular valves, and major blood vessels of the heart. Fresh heart (A); formalin-fixed heart (B, C).
fvets-10-1216439-g0001.jpg
PMC10391646_01_fvets-10-1216439-g0001.jpg
F1
The epicardium, epicardial adipose tissues, interatrial septum, the tunica adventitia of coronary vessels, pulmonary artery, and aorta, had multiple, adherent, firm, pale, multinodular masses ranging from 0.3 to 0.5 cm in diameter, which were red-to-white and marbled on cut surfaces (Figure 1A). After formalin-fixation, a longitudinal section of the heart revealed multiple, firm, yellow-rimmed, marbled masses with red-white centers that effaced the aortic, pulmonic, and atrioventricular valves, and both atria (Figures 1B, C).
Chemodectoma in a domestic cat, pulmonary artery and right atrium. Neoplastic cells expand and efface the tunica adventitia of the pulmonary artery, adjacent connective and adipose tissues, and invade the right atrium. Hematoxylin and Eosin stains (H&E). Sub-gross view (A) and higher magnification (B). Inset: 400X H&E.
fvets-10-1216439-g0002.jpg
PMC10391646_01_fvets-10-1216439-g0002.jpg
F2
McKinney, Texas, US. Microscopic evaluation of the masses in the heart revealed an infiltrative, non-encapsulated, poorly circumscribed, densely cellular multilobulated neoplasm composed by polygonal cells arranged in nests and packets and supported by a fine fibrovascular stroma (Figure 2). There were 22 mitotic figures in 2.37 mm2 (10 consecutive 400X fields).
Chemodectoma in a domestic cat, heart. Immunohistochemical analysis (IHC). Neoplastic cells stained strongly for synaptophysin (A, C) and chromogranin A (B, D).
fvets-10-1216439-g0003.jpg
PMC10391646_01_fvets-10-1216439-g0003.jpg
F3
Approximately 100% and 70% of neoplastic cells were strongly positive for synaptophysin and chromogranin A, respectively (Figure 3).