PMC8716376_01
Skin examination: (A) lower legs (B) back.
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Skin examination showed a purpuric maculopapular rash predominantly located on the lower legs ( Figure 1A ), thighs, buttocks, back ( Figure 1B ) and lower abdomen.
Skin sample showing intense neutrophilic infiltration of the blood vessels in the dermis with leukocytoclasis; (A) hematoxylin and eosin stain (HE) x20, (B) HE x 40.
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A skin biopsy showed a positive immunofluorescence for IgM and C3 within vascular walls, without IgA involvement (thus excluding Henoch-Schonlein purpura) and pathologist concluded to a leukocytoclasic vasculitis ( Figure 2 ).
Serum levels of carbohydrate antigen 19-9 (CA 19-9) during treatment and follow-up.
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Tumor marker decreased by half at the time of vasculitis resolution, to 262 kU/l ( Figure 3 ).