PMC9769079_01
Endoscopic view of the subglottic mass of the present case. A) Pre-operative examination of a mass below the true vocal cords, in the left antero-lateral wall of subglottis. B) Post-operative endoscopic view 1 year after subtotal excision showing a residue scar in the surgical field.
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The lesion was round, well circumscribed, and occupied about 20% of the airway lumen (Figure 1). At the last follow-up, 12 months after surgery, the fiberoptic laryngoscopy shown in Figure 1 demonstrated stable subglottic residual mass and bulges, comparable to the postoperative endoscopy.
Xanthogranuloma: A) H&E section (200x) showing an infiltrate composed of numerous histiocytes with clear vacuolated cytoplasm with large nuclei and prominent nucleoli associated to multinucleated Touton giant cells. Occasional figures of emperipolesis were observed. B) H&E (40x) Biopsy specimen lined by respiratory epithelium with lympho-plasma cellular infiltrate admixed to histiocytes. C) H&E (400x) detail of the picture shown in A. D-E) CD68 and CD163 expression, respectively, highlighting the histiocytic nature of these cells (IHC, anti-CD68 Ab and anti-CD163 Ab, 200x).
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