PMC6261234_01
Merkel cell carcinoma skin lesion.
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fig1
Fried egg appearance; bone marrow trephine (H&E stain).
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fig2
The bone marrow trephine demonstrated a "fried egg appearance," a morphological feature considered highly suggestive of HCL (Figure 2).
Merkel cell infiltration of bone marrow trephine (H&E stain).
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fig3
Bone marrow trephine also showed large nonhaematopoietic tumor cells appearing to grow in organoid formation suggestive of an undifferentiated carcinoma (Figure 3).
Chromogranin staining Merkel cells in BM trephine.
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fig4
Immunohistochemical stains were positive for cytokeratin-20 (CK-20), chromogranin A (Figure 4) and synaptophysin and negative for CD45, CD20, and cytokeratin-7 (CK-7).
(a, b) Hairy cells in the peripheral blood H&E stain.
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fig5
The characteristic cytoplasmic hairy projections of the lymphoid cells are demonstrated in Figures 5(a) and 5(b).