PMC6645694_01
Family history of patient. She did not have any family history of disease. Notes: Parents I (I-1 and I-2) and 3 siblings  (II-1, II-3, II-5) of patient (II-2) were unaffected. The 3rd sibling (II-4) died in his 40s.
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No additional family members were reported with similar neurodegenerative disease (Figure 1).
(A) Axial FLAIR image of the patient shows moderate atrophy in the bilateral cortices and (B) moderate atrophy in the hippocampus. (C) Coronal MRI image of patient. (D) Axial 18F-fluorbetaben positron emission tomography of the patient shows increased diffusion uptake over the bilateral cortices.
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The patient's MRI revealed global atrophy with medial temporal lobe and hippocampal atrophy predominance (Figures 2A-C). Aggravated diffuse brain atrophy and small vessel ischemic lesion were observed in follow-up MRI, but no specific abnormality was detected in diffusion-weighted image (DWI, Figures 2A-C). The Axial 18F-fluorbetaben positron emission tomography (FDG-PET) of the patient shows mild amyloid positivity, and increased diffusion uptake over the bilateral cortices, and increased cerebral cortex (Figure 2D.