PMC8096593_01
Colonoscopy showing submucosal nodularity.
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fig1
This revealed a normal mucosa but diffuse submucosal nodularity through the large intestine (Figure 1).
Hematoxylin and eosin stain showing lymphoid aggregate with normal colon mucosa.
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fig2
Biopsies were taken from multiple sites, and histopathology of the biopsied revealed multiple aggregates for small mature lymphocytes in the submucosa (Figure 2).
Lymphoid aggregate positive for PAX5 stain.
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fig3
Immunohistochemical stains revealed neoplastic lymphocytes positive for PAX5 (Figure 3), BCL-2, dim BCL-6, CD5, partial CD20, and CD23 and negative for CD3, cyclin D1 (Figure 4), and CD10.
Lymphoid aggregate negative for cyclin D1.
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fig4
Immunohistochemical stains revealed neoplastic lymphocytes positive for PAX5 (Figure 3), BCL-2, dim BCL-6, CD5, partial CD20, and CD23 and negative for CD3, cyclin D1 (Figure 4), and CD10.