PMC9174420_01
Clinical pictures of the patient. (A) One 2.0 x 2.5 cm purple papule on the right limbs after DRESS syndrome improved. (B) 2.5 x 2.5 cm purple papule on the right limbs after DRESS was cured.
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F1
The nodules were painful with a coarse texture and had a diameter of 2-3 cm (Figures 1A,B).
Skin histopathology of the patient. (A) A biopsy specimen of the right limb showed spindle cell proliferation, with intermingled erythrocytes seen in the dermis (Hematoxylin and eosin, x25). (B) Significant atypia of endothelial cells. (Hematoxylin and eosin, x100).
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F2
Histopathological examination of the sections demonstrated abnormal vessels and spindle cell proliferation, with intermingled erythrocytes (Figures 2A,B).
(A,B) Clinical pictures of the patient. After 4-month treatment with anlotinib, nodules begin to subside, leaving dark brown violaceous patches.
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F3
After 5 months of treatment, relief from pain was observed in patients and nodules began to subside, leaving dark brown, violaceous patches (Figures 3A,B).