PMC2627815_01
Preoperative photograph of patient 1.
1757-1626-2-15-1.jpg
PMC2627815_01_1757-1626-2-15-1.jpg
F1
This patient is a 48 year old female who was admitted with a large fungating right breast mass which measured 22 x 20 cm and elevated 12 cm above the skin surface (Figure 1).
Postoperative photograph of patient 1.
1757-1626-2-15-2.jpg
PMC2627815_01_1757-1626-2-15-2.jpg
F2
The skin flaps were viable, not grossly involved with tumor, and were able to be closed primarily (Figure 2).
Photomicrograph of carcinosarcoma (hematoxylin-eosin stain).
1757-1626-2-15-3.jpg
PMC2627815_02_1757-1626-2-15-3.jpg
F3
The final pathology revealed the left simple mastectomy containing a 2.7 cm carcinosarcoma characterized by a grade 3 epithelial component with an associated, but separate, high grade mesenchymal component (Figures 3 &4).
Photomicrograph of carcinosarcoma (cytokeratin stain).
1757-1626-2-15-4.jpg
PMC2627815_02_1757-1626-2-15-4.jpg
F4
The final pathology revealed the left simple mastectomy containing a 2.7 cm carcinosarcoma characterized by a grade 3 epithelial component with an associated, but separate, high grade mesenchymal component (Figures 3 &4).
Epidermal Growth Factor Receptor protein expression is analyzed by immunohistochemistry, staining positive.
1757-1626-2-15-5.jpg
PMC2627815_02_1757-1626-2-15-5.jpg
F5
Ki-67 expression was 60%, with expression of the HER-1/EGFR receptor with a 50% strong staining intensity (Figure 5).
PMC2627815_02
Photomicrograph of carcinosarcoma (hematoxylin-eosin stain).
1757-1626-2-15-3.jpg
PMC2627815_02_1757-1626-2-15-3.jpg
F3
The final pathology revealed the left simple mastectomy containing a 2.7 cm carcinosarcoma characterized by a grade 3 epithelial component with an associated, but separate, high grade mesenchymal component (Figures 3 &4).
Photomicrograph of carcinosarcoma (cytokeratin stain).
1757-1626-2-15-4.jpg
PMC2627815_02_1757-1626-2-15-4.jpg
F4
The final pathology revealed the left simple mastectomy containing a 2.7 cm carcinosarcoma characterized by a grade 3 epithelial component with an associated, but separate, high grade mesenchymal component (Figures 3 &4).
Epidermal Growth Factor Receptor protein expression is analyzed by immunohistochemistry, staining positive.
1757-1626-2-15-5.jpg
PMC2627815_02_1757-1626-2-15-5.jpg
F5
Ki-67 expression was 60%, with expression of the HER-1/EGFR receptor with a 50% strong staining intensity (Figure 5).