PMC7569497_01
Ileal wall, infiltration of pleomorphic neoplastic cells with light eosinophilic to clear cytoplasm (X400).
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F1
Specimen obtained from terminal ileum showed necrosis and ulceration as well as heavy transmural infiltration of pleomorphic neoplastic lymphoid cells with light eosinophilic to clear cytoplasm, some with prominent nucleoli including few multinucleated ones with bizarre nuclei (Figure 1).
Lung parenchyma with extensive necrosis infiltrated by pleomorphic neoplastic cells (X100).
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F2
CT-guided lung biopsy presented extensive areas of necrosis and patchy uneven interstitial thickening due to polymorphous cellular infiltration comprised of atypical adhesive cells with clear cytoplasm and pleomorphic atypical nuclei admixed with histiocytes including epithelioid ones, lymphocytes, few eosinophils and nuclear debris (Figure 2).
Predominantly cytoplasmic positive reaction of neoplastic cells for CD3 a pan T cell marker (X200).
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F3
Immunohistochemistry (IHC) staining demonstrated neoplastic cells positive for LCA, CD3, CD56, CD8, CD30 and EMA but negative for CK7, CK20, TTFI, AE1/AE3, CD19, CD20, CD5; while Ki67 proliferation index was high (70%) (Figure 3,4).