PMC9705984_01
Results of MRI, 3D-SSP of SPECT, 18F-florzolotau tau PET, and 18F-florbetaben amyloid PET. (A) MRI at the initial visit showed mild atrophy of the cerebrum, with a left predominance, and of the cerebellum. Hyperintense signals in the white matter suggest old lacunar infarctions and/or chronic ischemic changes. (B) 3D-SSP of SPECT at the initial visit showed a mild decrease in blood flow in the posterior cingulate gyrus, precuneus and cerebellum. (C)
18F-florzolotau tau PET at one-year follow-up showed intense radio signals predominantly in the left temporal lobe, particularly the superior temporal and middle temporal lobe, as well as the supramarginal gyrus, and marginal to mild signals in the frontal lobe. (D)
18F-florbetaben amyloid PET at one-year follow-up did not show intense radio signals, compared with age/sex-matched controls. AD, Alzheimer's disease; ANT, anterior; GLB, global; INF, inferior; L; left; LT, left; MED, medial; POST, posterior; R, right; RT, right; SUP, superior; SUVR, standard uptake value ratio; THL, thalamus; 3D-SSP, Three-dimensional stereotactic surface projections.
fneur-13-1049113-g0001.jpg
PMC9705984_01_fneur-13-1049113-g0001.jpg
F1
At the time of the patient's first visit to our hospital, visual assessments of magnetic resonance imaging (MRI) findings showed atrophy, particularly in the left temporal lobe and cerebellum; fluid-attenuated inversion recovery (FLAIR) imaging showed high signals in the white matter, suggesting old lacunar infarctions and/or chronic ischemic changes (Figure 1A). A statistical analysis using 3D-stereotactic surface projections (3D-SSP) showed a mild decrease in blood flow in the posterior cingulate gyrus, the precuneus and the cerebellum (Figure 1B). The accumulations of 18F-florzolotau were predominantly on the left side, particularly in the superior temporal gyrus, middle temporal gyrus, supramarginal gyrus, and frontal operculum (Figure 1C; see Supplementary Figure 1 for more details). We used PMOD software (PMOD Technologies, Zurich, Switzerland) to process the 20-min PET images, and tau positivity or negativity was determined based on assessments of tracer uptake using SUVR with reference to the cerebellum. 18F-FBB amyloid PET images with dynamic range are shown in Figure 1D.