PMC10071209_01
Intravascular diffuse large B-cell lymphoma: (a) multiple grey-violaceous
macules and patches, non-blanching on diascopy and (b) extensive dry 'fish
scale' like skin on extremities.
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PMC10071209_01_10.1177_2050313X231163630-fig1.jpg
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Skin examination revealed multiple asymptomatic non-blanching, bruise-like grey-violaceous patches on her trunk, abdomen, and back (Figure 1(a)). Acquired ichthyosis was noticed on extremities, sparing palms, and soles (Figure 1(b)).
Cutaneous biopsy revealing intravascular proliferation of large atypical
B-cells associated with thrombi.
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PMC10071209_01_10.1177_2050313X231163630-fig2.jpg
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Cutaneous biopsy revealed an intravascular proliferation of large, atypical B-cells with thrombi, with positive staining for BCL2, MUM1, and Myc by neoplastic cells and partial BCL6 staining (Figure 2).