PMC3643363_01
Nodular sclerosing adenosis: Cytomorphological and corresponding histological features. (a) Irregular cohesive clusters of cells along with naked nuclei and bipolar cells in the background; (b) Hyalinized eosinophilic stromal fragments; (c) Acinar formation; (d) Moderate nuclear pleomorphism and nucleoli; (e) Histological section showing tubular arrangement showing atypia, compressed by stroma; (f) Immunohistochemistry showing SMA positivity (a, c, d, e, H and E ; b, MGG ; f, immunoperoxidase; original magnification: a, b, x200; c-f, x400)
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F1
The smears were highly cellular and showed predominantly three-dimensional cohesive clusters and few scattered cells [Figure 1a and b]. At places, the clusters showed acinar formation [Figure 1c]. Occasional clusters of apocrine cells and singly scattered large cells with moderate nuclear pleomorphism and conspicuous nucleolus were also found [Figure 1d]. Admixed benign cell clusters, few bipolar cells and hyalinized eosinophilic stroma were found in the background [Figure 1b]. The lining cells showed moderate nuclear pleomorphism and atypia [Figure 1e]. The individual glands were surrounded by myoepithelial cells which were confirmed by immunohistochemistry for smooth muscle actin (SMA) [Figure 1f].