PMC5836235_01
Barium enema showing filling defects and a partial ileum stricture (arrows).
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F1
Barium enema showed filling defects of the ileum (Fig. 1).
Small-bowel CT demonstrating bowel thickening, distal bowel dilation, and "comb" sign (arrows).
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F2
CT (Fig. 2). Colonoscopy was performed and returned without ulcers or nodularities.
Surgical specimen showing ileum fibrosis and stenosis, and multiple cobblestone appearances (arrows).
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F3
The surgical specimen showed severe fibrosis and stenosis of 6 cm in length, the maximum depth of the lesion was 1.8 cm, additional to multiple cobblestone appearances (Fig. 3).
a Diffused lymphohistiocytic infiltration and well-formed granulomas were observed microscopically (HE x20) (arrows). b Periodic acid-Schiff staining revealed budding forms of histoplasma capsulatum within macrophages (HE x40) (arrows).
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F4
Hematoxylin and eosin staining and immunohistochemistry with periodic acid-Schiff revealed budding forms of histoplasma capsulatum within the macrophages (Fig. 4).