PMC4505076_01
Segment 1. Before Amantadine Treatment. Forced, painful, retrograde elevation of the right arm. The patient can be seen constantly holding her right arm with her left hand to prevent the alien movement. The video also details the difficulty that the patient experienced performing simple tasks with her right hand, because the right hand was acting on its own. Segment 2. After Amantadine Treatment. Although significant right arm paresis is evident, forced arm elevation is minimally evident and she can perform simple tasks with her right arm much better. Occasionally one can see that mild to moderate alien hand symptoms persisted. Significant apraxia is also quite evident, i.e. the patient could not clap her hands and tried but could not show how to comb her hair with her hands.
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v01
Brain MRI revealed generalized atrophy (including significant atrophy of the temporal lobes, Figure 1A), multiple lacunar strokes, and leukoaraiosis (mild, mainly periventricular white matter disease, Figure 1B), but no asymmetric hemispheric atrophy (Figures 1A and 1B).