PMC10413252_01
Fundus photography and fluorescein angiography of the patient's affected right eye at the week 4 after inoculation. Gross appearance on the photographs was similar to findings in the third week after inoculation. A: Fundus photo of the right eye showing whitening of an arterial branch close to the disc (branch at <500 microm from the 11-12 o'clock disc margin) that projects temporally, passing the mid-superior papillomacular area, onto the superior para-perifovea. Flanking dot hemorrhages and background retinal whitening are seen in both areas. B-C: Delayed perfusion and superonasal para-perifoveal staining. D-F: Dull-white patches seen scattered across the retina of both eyes. G-H: Staining of the dull-white patches seen on recirculation of both eyes.
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F1
Flanking dot hemorrhages and background retinal whitening were seen in both areas (Figure 1A (Fig. 1)). Few (<10) dull-white patches sized ~125-500 microm were scattered in the superior fundus bilaterally (Figure 1D-F (Fig. 1)). Fluorescein angiography revealed delayed perfusion in the described right macular areas (Figure 1A-C (Fig. 1)). Noted in the right eye: (1) superior foveal thinning with intact central foveal depression, and (2) focal retinal pigment epithelium (RPE) detachments in the area of granular staining in the superonasal para-perifovea (Figure 2A (Fig. 2), which corresponds to Figure 1C (Fig. 1)).
Optical coherence tomography (OCT) at week 4 after inoculation. A: Right eye OCT of the area of superonasal para-perifoveal staining seen in Figure 1C. RPE detachments are seen. B: Left eye OCT of the area of granular staining in the mid-inferior papillomacular area. Bumpy RPE-BM contour is seen.
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F2
Noted in the right eye: (1) superior foveal thinning with intact central foveal depression, and (2) focal retinal pigment epithelium (RPE) detachments in the area of granular staining in the superonasal para-perifovea (Figure 2A (Fig. 2), which corresponds to Figure 1C (Fig. 1)). Noted in the left eye: bumpy RPE-basement membrane contour in an area of staining in the mid-inferior papillomacular area (Figure 2B (Fig. 2)).
Optical coherence tomography (OCT) at week 4 after inoculation. A-B: OCT of the dull-white lesions seen in both eyes. They are rNFL/inner retinal nodularities with homogeneous mid-high reflectivity and posterior shadowing.
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F3
The dull-white lesions demonstrated well-defined staining and were seen as retinal nerve fiber layer (rNFL) - level nodularities with homogeneous mid-high reflectivity and some posterior shadowing (Figure 3A-B (Fig. 3)).