PMC6985093_01
Contrast-enhanced CT of the kidneys in patient K. The left kidney examined prior to the second surgery is indicated.
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F1
Compared to the previous scan, which was performed 2 months earlier, one large mass had increased to 4.0 x 3.2 cm (previously 3.7 x 3.0 cm) at the posterior surface, whereas the other masses remained unchanged (Figure 1).
Pathomorphological examination of the mass excised from the right kidney of patient K. Type I papillary RCC. Hematoxylin-eosin staining, magnification x100.
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F2
Microscopic examination revealed that they were structurally similar, and the tumors were identified as type I papillary RCC, Fuhrman grade 2 (Figure 2).
Sanger sequencing of part of MET exon 16 in patient K. The c.3328G>A (p.V1110I) mutation is indicated by the letter R.
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F3
The single-nucleotide substitution c.3328G>A was found in exon 16 in a heterozygous state (Figure 3).