PMC9354618_01
Schematic of basic hospital course for each patient included in this series. Days of admission, transfer to general pediatric ward, and discharge (D/C) are shown. LDPMI measurements were taken on days 1, 3, 7, and 14 for each patient.
fped-10-939886-g0001.jpg
PMC9354618_01_fped-10-939886-g0001.jpg
F1
Measurements were repeated on Days 1, 3, 7, and 14 using the same protocol and measurement sites (Figure 1).
Individual LDPMI vascular response recordings for each patient. Measurements were collected at 0.03 s intervals then displayed as averaged perfusion units every 5 s to generate the plots to reduce movement artifacts. Acetylcholine (ACh) responses are in red, sodium nitroprusside (SNP) responses are in blue. Solid vertical lines separate days of measurement, dashed vertical lines are 2 min intervals to estimate individual iontophoresis pulses.
fped-10-939886-g0002.jpg
PMC9354618_03_fped-10-939886-g0002.jpg
F2
Raw LDPMI measurements for each patient (Figure 2) and comparisons across patients (Figure 3) are shown. Endothelial-dependent ACh peak response, ACh response change, and ACh area under the curve were relatively homogeneous across the three patients included in this series, despite their dissimilar presentations and course (Figures 2, 3).
Respective LDPMI assessments to acetylcholine (ACh) and sodium nitroprusside (SNP) for each patient on the stated day of hospitalization. The peak response (maximal perfusion), the response change (the change in baseline perfusion to peak response) and the area under the curve (cumulative dose response) are shown at each of the time points. Friedman chi-squared tests were used to assess similarity of non-parametric repeated measurements across the three patients.
fped-10-939886-g0003.jpg
PMC9354618_03_fped-10-939886-g0003.jpg
F3
Raw LDPMI measurements for each patient (Figure 2) and comparisons across patients (Figure 3) are shown. Endothelial-dependent ACh peak response, ACh response change, and ACh area under the curve were relatively homogeneous across the three patients included in this series, despite their dissimilar presentations and course (Figures 2, 3).
PMC9354618_02
PMC9354618_03
Individual LDPMI vascular response recordings for each patient. Measurements were collected at 0.03 s intervals then displayed as averaged perfusion units every 5 s to generate the plots to reduce movement artifacts. Acetylcholine (ACh) responses are in red, sodium nitroprusside (SNP) responses are in blue. Solid vertical lines separate days of measurement, dashed vertical lines are 2 min intervals to estimate individual iontophoresis pulses.
fped-10-939886-g0002.jpg
PMC9354618_03_fped-10-939886-g0002.jpg
F2
Raw LDPMI measurements for each patient (Figure 2) and comparisons across patients (Figure 3) are shown. Endothelial-dependent ACh peak response, ACh response change, and ACh area under the curve were relatively homogeneous across the three patients included in this series, despite their dissimilar presentations and course (Figures 2, 3).
Respective LDPMI assessments to acetylcholine (ACh) and sodium nitroprusside (SNP) for each patient on the stated day of hospitalization. The peak response (maximal perfusion), the response change (the change in baseline perfusion to peak response) and the area under the curve (cumulative dose response) are shown at each of the time points. Friedman chi-squared tests were used to assess similarity of non-parametric repeated measurements across the three patients.
fped-10-939886-g0003.jpg
PMC9354618_03_fped-10-939886-g0003.jpg
F3
Raw LDPMI measurements for each patient (Figure 2) and comparisons across patients (Figure 3) are shown. Endothelial-dependent ACh peak response, ACh response change, and ACh area under the curve were relatively homogeneous across the three patients included in this series, despite their dissimilar presentations and course (Figures 2, 3).