PMC4742640_01
(A) A 29-year-old woman presenting with a 3-month history of palpable mass in the right upper eyelid (asterisk) that developed 10 months after an injection of cryopreserved autologous fat into her face. (B) A T1-weighted axial magnetic resonance image shows a fat-containing lesion with peripheral enhancement (arrow) and adjacent skin enhancement in the right upper eyelid. (C,D) Typical findings of granulomatous foreign body reaction with diffusely infiltrated chronic granulomatous inflammatory cells with fat necrosis and fibrosis (hematoxylin and eosin stain, x100, x400).
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F1
A 29-year-old woman presented with a 3-month history of palpable mass in her right upper eyelid (Fig. 1A). Orbit MRI scan showed a fat-containing lesion with peripheral enhancement and adjacent skin enhancement in the right upper eyelid area (Fig. 1B). Histological examination revealed foreign body reaction-induced lipogranuloma with fat necrosis (Fig. 1C and 1D).
PMC4742640_02
(A) A 31-year-old woman presenting with a 3-week history of palpable mass in the right upper eyelid (asterisk) that developed 7 months after an injection of cryopreserved autologous fat into her forehead. (B) A T2-weighted coronal image reveals multiple lesions (arrows) of heterogeneous high signal intensity in both upper eyelids.
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F2
Seoul National University Bundang Hospital with a 3-week history of swelling and palpable mass in her right upper eyelid (Fig. 2A). Seven months prior to her referral, she had autologous fat harvested from her thigh and injected into her forehead by a plastic surgeon, followed by a second injection 2 months later with cryopreserved fat. Orbital MRI showed multiple bubble-shaped enhancing lesions compatible with lipogranulomas in both upper eyelids (Fig. 2B).