PMC4899656_01
Erosive, atrophic, well-demarcated scaly erythema with on the patient's right palm (a) and right sole (b).
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PMC4899656_01_cde-0008-0031-g01.jpg
F1
On his initial visit, physical examination revealed erosive, atrophic, well-demarcated scaly erythema on his right palm and right sole (fig. 1a, b).
Atypical large lymphocytes densely infiltrated mainly in the upper dermis with involvement of the overlying epidermis (a). Paraffin-embedded tissue samples were deparaffinized and stained with anti-POSTN (b), anti-CD163 (c) and anti-CD206 antibodies (d). The sections were developed with liquid permanent red. Original magnification: a x200, b-d x100.
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PMC4899656_01_cde-0008-0031-g02.jpg
F2
A biopsy specimen showed atypical large lymphocytes densely infiltrated mainly in the upper dermis with involvement of the overlying epidermis (fig. 2a). IHC staining for POSTN, CD163 and CD206. IHC staining revealed the dense deposition of POSTN within the superficial to deep dermis (fig. 2b), where CD163+ macrophages were densely infiltrated (fig. 2c). Few CD206+ cells were detected in the lesional skin of the dermis (fig. 2d).