PMC9283086_01
Applications of clinical mNGS testing and prognosis of patients after liver transplantation. (A) Application of mNGS to diagnose infection after liver transplantation and adjustment of drug according to mNGS results improved the patient's condition. (B) Analysis of mortality and survival in infected and uninfected patients. (C) The mortality rate of liver transplant recipients within 1 week /2 weeks.
fmicb-13-919363-g0005.jpg
PMC9283086_02_fmicb-13-919363-g0005.jpg
F5
The sequencing results showed that the patient was infected with Candida glabrata, and Mycin tablets were prescribed for 7 days for antifungal treatment (Figure 5A). We further analyzed the infection and survival of the patients within 1 week after liver transplantation (Table 1) and plotted the survival curve (Figure 5B). Notwithstanding that some infections were detected and treated in time due to mNGS, the overall fatality rate of the infected group was still ~3-fold higher than the non-infected group (13.33 vs. 38.46%, p = 0.029; Figure 5B), indicating that the prevention and diagnosis of infection after LT are equally important and require much emphasis. Table 3) and compared them with the data of this study. The results showed that the 1-week and 2-week mortality rates were 1.30% (1/76) and 2.63% (2/76), respectively, in patients undergoing liver transplantation with mNGS and 4.5% (5/111) and 7.21%, respectively, in patients without mNGS (Figure 5C).
PMC9283086_02
Applications of clinical mNGS testing and prognosis of patients after liver transplantation. (A) Application of mNGS to diagnose infection after liver transplantation and adjustment of drug according to mNGS results improved the patient's condition. (B) Analysis of mortality and survival in infected and uninfected patients. (C) The mortality rate of liver transplant recipients within 1 week /2 weeks.
fmicb-13-919363-g0005.jpg
PMC9283086_02_fmicb-13-919363-g0005.jpg
F5
The sequencing results showed that the patient was infected with Candida glabrata, and Mycin tablets were prescribed for 7 days for antifungal treatment (Figure 5A). We further analyzed the infection and survival of the patients within 1 week after liver transplantation (Table 1) and plotted the survival curve (Figure 5B). Notwithstanding that some infections were detected and treated in time due to mNGS, the overall fatality rate of the infected group was still ~3-fold higher than the non-infected group (13.33 vs. 38.46%, p = 0.029; Figure 5B), indicating that the prevention and diagnosis of infection after LT are equally important and require much emphasis. Table 3) and compared them with the data of this study. The results showed that the 1-week and 2-week mortality rates were 1.30% (1/76) and 2.63% (2/76), respectively, in patients undergoing liver transplantation with mNGS and 4.5% (5/111) and 7.21%, respectively, in patients without mNGS (Figure 5C).