PMC3336059_01
Histopathologic features on biopsies. The second and third biopsies showing the histologic findings before and after CSA treatment. a-b Histologic findings in the second biopsy, representing the pathology before CSA treatment. Urothelial separation, subepithelial hemorrhagia, edematous lamina propria, and infiltration of inflammatory cells are seen (a). Increase in mast cells is remarkable in the inflammatory infiltration as shown by mast cell tryptase (b). c-d Histologic findings in the third biopsy, showing the effects of CSA treatment. Regenerative properties in urothelium and slight edema in lamina propria and early fibrosis findings (c). CD117 immunostaining shows decrease in the number of mast cells (d)
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Fig1
Mast cell tryptase activity implicated substantially increased mast cells (Fig. 1a, b). It was found that hemorrhagia and edema in the lamina propria were replaced by early fibrosis and there was only slight inflammatory infiltration mostly consisting of mononuclear cells (Fig. 1c, d). 