PMC5929393_01
A: MRI shows right nasoethmoidal mass with erosion of cribriform plate.
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F1
MRI (Magnetic Resonance Imaging) scan with contrast (Fig 1A) revealed right nasoethmoidal mass eroding the cribriform plate with intracranial extension on the right side. Epithelial component was composed of nests of poorly differentiated cells to well differentiated squamous cells with keratin pearl formation (Fig 1B) and glands filled with mucin (Fig 1C). In addition to osteoid formation (Fig 1D).
A: Rhabdomyosarcomatous differentiation (H and E, 200X magnification).
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F2
There were areas of rhabdomyosarcomatous differentiation (Fig 2A) and immature cartilage. Islands of primitive neuroepithelial tissue with true rosettes and pseudorosettes (Fig 2B) were also seen. Immunohistochemistry showed expression of vimentin in the mesenchymal component, desmin (Fig 2C) in rhabdomyosarcomatous areas, neuron-specific enolase (Fig 2D) in primitive neuroepithelial component, cytokeratin and epithelial membrane antigen (Fig 3A) in the epithelial component and CD99 (Fig 3B) in primitive neuroepithelium.
A: Squamous epithelium is EMA positive (IHC, 200X magnification).
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F3
Immunohistochemistry showed expression of vimentin in the mesenchymal component, desmin (Fig 2C) in rhabdomyosarcomatous areas, neuron-specific enolase (Fig 2D) in primitive neuroepithelial component, cytokeratin and epithelial membrane antigen (Fig 3A) in the epithelial component and CD99 (Fig 3B) in primitive neuroepithelium.