PMC9580272_01
Segmental microthrombosis and mesangiolysis with entrapped erythrocytes (blue arrow) and arteriole with narrowed lumen due to marked intimal edema (yellow arrow) (HE-400x).
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None of the 16 glomeruli found have been obsolescent yet ( Figures 1  and  2 ).
Segmental microthrombosis is highlighted by immunostain for CD61 (platelet-specific glycoprotein) (CD61-400x).
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None of the 16 glomeruli found have been obsolescent yet ( Figures 1  and  2 ).
Chronic TMA represented by segmental glomerulosclerosis (blue arrow) (PAS-400x).
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TMA symptoms completely disappeared only after a few weeks of treatment, and mild renal dysfunction persisted. Therefore, a second renal biopsy was performed 4 months later (February 2022) with a similar finding as in the first, but with a progression of tubulointerstitial fibrosis to 35% and signs of already present tubular atrophy ( Figure 3 ).