PMC5726671_01
A-C: Numerous erythemas with papules, vesicles, tense
blisters, erosions, and crusts were observed on the entire body.
D: Numerous milia during recovery
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f1
On the skin, multiple papules, vesicles, tense blisters with serous content and different sizes, erosions and crusts, and an extensive erythema were observed on the entire body (Figure 1). At six months of follow-up, no relapse was observed and a resolution of his condition was seen, with an appearance of numerous milia left on the skin and the healing of the decubitus ulcer (Figures 1 and 2).
A - A giant decubitus ulcer was presented on sacrococcygeal
area. B - Decubitus ulcer during recovery
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f2
In addition, a giant decubitus ulcer appeared on sacrococcygeal area (Figure 2). At six months of follow-up, no relapse was observed and a resolution of his condition was seen, with an appearance of numerous milia left on the skin and the healing of the decubitus ulcer (Figures 1 and 2).
Histopathology of the skin lesion revealed subepidermal blisters
(Hematoxylin & eosin, X10) and infiltration of numerous eosinophils
in the upper dermis (Hematoxylin & eosin, X40)
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f3
A skin biopsy taken from a bullous lesion showed subepidermal blisters and infiltration of numerous eosinophils in the upper dermis (Figure 3).
Direct immunofluorescence showed linear IgG and C3 deposits along the
subepidermal basal membrane zone
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f4
Direct immunofluorescence (DIF) detected the presence of linear IgG and C3 deposits along the subepidermal basal membrane zone (Figure 4).