PMC5537453_01
The mammogram showed a 2,5 cm single mass with well defined contour at junction bet- ween the superior outer quadrant and the axillary tail of the right breast.
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fig0005
The ultrasound findings showed a homogeneously hypoecoic lump with an oval shape and well-defined margins, no vascularity was seen at Color Doppler.
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(A) (H&E, 10x): microscopic examination showed fibrous bands circumscribing lymphoid nodules. (B) (H&E, 40x): numerous large cells with retraction of the cytoplasm (lacunar cells) within small lymphocytes. (C) (CD30 staining, 40x): Reed-Sternberg cells showed dot-like positivity for CD30. (D) (CD15 staining, 40x): Reed-Sternberg cells showed intense membranous positivity for CD15.
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fig0015
A diagnosis of nodular sclerosis variant of classical Hodgkin disease with syncytial features was rendered (Fig. 3).