PMC3296588_01
Endobronchial biopsy: Squamous cell carcinoma (*) composed of sheets of large polygonal cells exhibiting keratinization, intercellular bridges and keratin pearls (arrow). HE, 200x.
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F1
Bronchoscopic biopsies revealed a moderately differentiated Squamous cell carcinoma (Figure 1).
CT scan of the splenic metastasis at postoperative months 16, 28 and 30 (right to left).
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F2
Paclitaxel and 50 Gy). Patient remained asymptomatic and sixteen months after surgery a CT scan revealed a 1 x 1 cm cystic lesion in the spleen (Figure 2). This exam revealed an interlobular thickening and an enlargement of the splenic lesion now measuring 6.5 x 6.4 cm (Figure 2). A new CT scan showed stability of the pulmonary disease but progress of the splenic lesion (7.8 x 7.8 cm - Figure 2).
Splenic metastasis from squamous cell carcinoma of the esophagus. Splenic capsule (*), white pulp (**) and red pulp (***) invaded by squamous cell carcinoma. HE, 100x.
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F3
Pathologic findings consisted of a splenic metastasis with the red pulp being invaded by a moderately differentiated squamous cell carcinoma with keratinization and intercellular bridges (Figure 3 and 4).
Red pulp (*) invaded by the squamous cell carcinoma (**). Tumor cells exhibit keratinization and intercellular bridges and keratin pearls. HE, 200x.
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F4
Pathologic findings consisted of a splenic metastasis with the red pulp being invaded by a moderately differentiated squamous cell carcinoma with keratinization and intercellular bridges (Figure 3 and 4).
Invasive adenocarcinoma of the sigmoid colon, invading through the muscularis propria (*) into the subserosal adipose tissue (**). HE, 100x.
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F5
It invaded the subserosal and 3 out of 19 lymph nodes were compromised (pT3pN1b) - Figure 5.