PMC3156767_01
Timeline of treatment and biopsy obtainment.. We investigated 5 serial iliac crest biopsies from a 75-year-old female patient over a period of 6 years. The patient was diagnosed with osteoporosis with multiple vertebral fractures and was first treated with bisphosphonates (BP) for 26 months (biopsy 1). The BP treatment was halted for 12 months until a second biopsy was obtained (biopsy 2). The BP treatment was then continued and another biopsy was taken after 13 months (biopsy 3). The antiresorptive therapy was stopped after an additional 51 months of treatment and another biopsy was taken (biopsy 4). Next, strontium ranelate was administered for 12 months (2g/d) in total before another iliac crest biopsy was conducted. BP and SR were administered according to the manufacturer's instructions and the patient additionally received a Vitamin D3 metabolite during osteoporosis treatment.
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pone-0023638-g001
All of the biopsies were taken during the BP and SR treatment periods (Fig. 1), see the timeline in figure 1.