PMC9649447_01
Timeline. White bars represent important timepoints along G's development. Dark gray bars represent triggering event. Light gray horizonal bars represent given treatment. Light green/orange bars represent efficacy. Time scale is not linear.
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F1
This dose was found to be sufficient throughout the treatment period, and no increase in dose was required, indicating that the terpene-enriched CBD oil was more potent (Terpene-enriched CBD treatment was accompanied the 7.5 mg daily dose of Abilify, as before) (See Figure 1 for timeline summary).
Treatment efficacy of the pure CBD (white bars) and the Terpene-enriched CBD (gray bars) oils. G's parents were asked to rate symptoms' severity in their child following CBD oil treatment ("How would you evaluate your child's symptom severity following oil treatment (how did the oil affected your child in regard the following symptoms)?". A self-reported questionnaire, see Supplementary data). This was evaluated separately for the pure CBD and the terpene-enriched CBD oils.
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F2
August 2021, G has completed 9 months of treatment with terpene-enriched CBD oil. As can be seen in Table 1 and in Figure 2, aggression was significantly reduced, from two major aggressive events per week during treatment with synthetic CBD oil, to a complete elimination of aggressive events during treatment with the same synthetic CBD oil enriched with the selected terpene blends.