PMC7457046_01
Magnetic resonance imaging showed conspicuous supratentorial white matter lesions without contrast enhancement. This is compatible with chronic inflammatory brain disease.
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An MRI of the neurocranium showed several conspicuous FLAIR-hyperintense supratentorial WM lesions (among others, ovoid periventricular WM lesions on both sides, in the corpus callosum, and in the right side of the crus cerebri) without contrast enhancement which was assessed to be compatible with chronic inflammatory brain disease (Figure 1).
A tissue-based assay using indirect immunofluorescence screening on brain sections of rodents showed binding of especially cerebrospinal fluid antibodies to granule cells in the granule cell layer of the cerebellum and the hippocampus and in the corpus callosum. Methodological aspects of the antibody test are described in Kreye et al. and Edwin Thanarajah et al.. ANA, antinuclear antibodies; CSF, cerebrospinal fluid; GC, granule cell; Corp., corpus.
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The neuronal signal was also detectable in the corpus callosum (Figure 2).