PMC10183565_01
The lesion in the left lobe of liver was detected on CT.
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Abdominal computed tomography (CT) showed the lesion in the left lobe of liver was detected, and no tumor was detected in any other organs (Figure 1).
Magnetic Resonance Imaging showed a 1.1x1.3 cm lesion in the left lobe of liver. (A) low signal intensity on T1-weighted images; (B) high signal intensity on T2-weighted images; (C) ring enhancing on DWI image; (D) ADC image of the lesion (ADC value: 800).
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The MRI showed a 1.1x1.3 cm lesion in the left lobe of liver, appearing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images (Figure 2).
Pathological examination and immunohistochemical staining. (A) Tumor was composed of undifferentiated epithelial cells with some atypical glands, and significant lymphocytic infiltration (HE stain, x20); (B, C) Lymphatic tissue positive for CD20 (B-cells, B, x20), CD3 (T-cells, C, x20); (D) tumor cells positive for CK7 (immunostaining, x20).
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Microscopically, the lesion composed of undifferentiated epithelial cells with some atypical glands, and significant lymphocytic infiltration (Figure 3A). In addition, immunohistochemical analysis showed the lymphatic tissue positive for CD20 (B-cells, Figure 3B), CD3 (T-cells, Figure 3C), Ki-67 and negative for IgG4. Meanwhile, tumor cells positive for CK7 (Figure 3D), and negative for CK20, supporting the diagnosis of LEL-ICC.
CT showed the patient was free from tumor recurrence after a 28 months follow-up.
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The patient was free from tumor recurrence after a 28 months follow-up (Figure 4).