PMC6745162_01
Large fungating mass centered in the duodenum.
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fig1
The mass was centered in the lumen of the duodenum with a well-demarcated (pushing) front of macroscopic invasion into the pancreas (Figure 1).
(a and b) Duodenal tumor adjacent to pancreatic heterotopia composed of pancreatic acini, islets of Langerhans, and ducts (original magnification x100 and x200).
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fig2
The neoplasm was located in the duodenum adjacent to an area of pancreatic heterotopia (Figures 2(a) and 2(b)).
(a and b) Neuroendocrine cell component (original magnification x100 and x400).
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fig3
Some other areas demonstrated pseudorosettes (Figures 3(a) and 3(b)), while others showed a typical acinar pattern with cells that had moderate to abundant granular eosinophilic cytoplasm, nuclei with open chromatin and prominent nucleoli, and increased mitotic figures (40/10 hpf) (Figures 4(a) and 4(b)).
(a and b) Acinar cell component (original magnification x100 and x400).
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fig4
Some other areas demonstrated pseudorosettes (Figures 3(a) and 3(b)), while others showed a typical acinar pattern with cells that had moderate to abundant granular eosinophilic cytoplasm, nuclei with open chromatin and prominent nucleoli, and increased mitotic figures (40/10 hpf) (Figures 4(a) and 4(b)).
(a and b) Trypsin positivity in the acinar component (original magnification x100 and x200).
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fig5
(a and b) Synaptophysin in the neuroendocrine component (original magnification x100 and x200).
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fig6
BCL-10, as well as a neuroendocrine population that stained positively for synaptophysin (Figures 6(a) and 6(b)) and chromogranin (Figures 7(a) and 7(b)). Both acinar and neuroendocrine cell populations made up >25%-30% of the lesion, thus the patient was diagnosed with a MAEC.
(a and b) Chromogranin in the neuroendocrine component (original magnification x100 and x200).
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fig7
BCL-10, as well as a neuroendocrine population that stained positively for synaptophysin (Figures 6(a) and 6(b)) and chromogranin (Figures 7(a) and 7(b)). Both acinar and neuroendocrine cell populations made up >25%-30% of the lesion, thus the patient was diagnosed with a MAEC.