PMC7071809_01
Fungating tumour with active bleeding from the erosion.
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Five years following the initial diagnosis, she presented with a rapidly enlarging right breast lump with skin erosion and bleeding of 2 weeks duration (Figure 1).
(a and b) Microscopic analysis showing anastomosing channels of vascular spaces lined by atypical cells with markedly pleomorphic vesicular nuclei and moderate eosinophillic cytoplasm. (c) Diffuse sheets and infiltrating cords of cells, areas of necrosis and blood lakes. (d) Tumour infiltration around the mammary ducts and surrounding fatty tissues.
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Microscopic analysis of all lesions showed similar features with anastomosing channels of vascular spaces lined by atypical cells with markedly pleomorphic vesicular nuclei and moderate eosinophillic cytoplasm (Figure 2). There was tumour infiltration around the mammary ducts and surrounding fatty tissues (Figure 2).
Immunohistochemical analyses showing strong and diffuse cytoplasmic and membrane positivity for CD 31 and occasional cytoplasmic and membrane positivity for CD 34. Tumour cells were negative for PanCK., ER, PR, and HER-2.
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Immunohistochemical analyses showed strong and diffuse cytoplasmic and membrane positivity for CD 31 and occasional cytoplasmic and membrane positivity for CD 34 (Figure 3).