PMC9430984_01
Cutaneous leiomyomas on patient's back, leading to suspicion of hereditary leiomyomatosis and renal cell cancer (HLRCC).
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F1
After multiple reddish-brown, painful skin nodules appeared on her arms, legs, and back, she had a skin biopsy, which confirmed piloleiomyomas (Figure 1).
Pathology of RCC. (A) Neoplasm with papillary-predominant pattern, formed by clear cells with an irregular nucleus and a perinucleolar halo. (B) Immunohistochemistry with antibody for fumarate hydratase presents immunoreactivity only in stromal cells, while tumoral cells are negative.
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F2
A computed tomography (CT) scan demonstrated three contrast-enhancing renal tumors of the right kidney, with diameters of 4.9, 4.8, and 1.7 cm (Figure 2).
Pedigree of the patient.
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F3
The patient's family history also included a brother and other relatives having cutaneous leiomyomas (Figure 3).