PMC10076113_01
Factor XI activity levels as measured over time. Transfusions 1 and 2 with corresponding allergic reactions took place on 4/8/22. Transfusion 3 with pretransfusion medication to limit allergic reaction symptoms, a total of 2 units, took place on 4/11/22. Transfusion 4, similar to transfusion 3, but with 3 units in total took place on 4/12/22. The CABG took place on 4/19/22.
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Preoperative laboratory values were significant for a platelet count of 77,000 (K/mul), an activated partial thromboplastin time (aPTT) of 73.7 seconds (normal range 30-40 seconds), and a severely reduced fXI activity assay at <2% (normal >65%) (Figure 1). FFP over a period of ten hours without incident. Follow-up aPTT results were obtained with correction from presentation (70 to 36) and fXI activity increased to 25%, however it never approached normal values of greater than 65% (Figure 1).
Platelet counts over time. Transfusions 1 and 2 with corresponding allergic reactions took place on 4/8/22. Transfusion 3 with pretransfusion medication to limit allergic reaction symptoms, a total of 2 units, took place on 4/11/22. Transfusion 4, similar to transfusion 3, but with 3 units in total took place on 4/12/22. The CABG took place on 4/19/22.
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Hemoglobin concentrations preoperatively, intraoperatively, and postoperatively were also tracked (Figures 2 and 3).
Activated partial thromboplastin time (aPTT) over time. Transfusions 1 and 2 with corresponding allergic reactions took place on 4/8/22. Transfusion 3 with pretransfusion medication to limit allergic reaction symptoms, a total of 2 units, took place on 4/11/22. Transfusion 4, similar to transfusion 3, but with 3 units in total took place on 4/12/22. The CABG took place on 4/19/22.
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Hemoglobin concentrations preoperatively, intraoperatively, and postoperatively were also tracked (Figures 2 and 3).