PMC8641106_01
Coronal (left) and axial (right) magnetic resonance images demonstrating a 2.3 x 1.0 x 2.7 cm dural-based mass (yellow arrows) in the left frontoparietal region with associated thickening and enhancement of the adjacent dura. There is an extracranial component to the mass in the adjacent soft tissues without visible abnormalities of the bone. In addition, there are linear extension into the gyri of the adjacent brain parenchyma with an associated focal area of subcortical edema in the lateral aspect of the postcentral gyrus.
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Magnetic resonance imaging demonstrated a 2.3 x 1.0 x 2.7 cm dural-based mass in the left frontoparietal region with extension into the gyri of the adjacent brain parenchyma (Figure 1).
(A) The dura demonstrates infiltration of fibrous tissue by a vaguely nodular lymphocytic infiltrate (hematoxylin and eosin, 40x magnification). (B) Closer inspection of 1 of the nodular areas reveals the infiltrate to consist of a mixture of small lymphocytes with cleaved nuclei (centrocytes) and large lymphocytes with multiple nucleoli (centroblasts) (hematoxylin and eosin, 400x magnification).
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IIIA (Figure 2). Immunohistochemical stains showed predominantly CD20(+)/Pax-5(+) B cells that were reactive for both Bcl-2 and Bcl-6 (Figure 3).
(A) Lymphocytes express CD20, consistent with B cells (CD20 immunohistochemical stain, 200x magnification). (B) CD21 highlights retained follicular dendritic cell meshworks (CD21 immunohistochemical stain, 200x magnification). B cells show aberrant co-expression of (C) Bcl-2 and (D) Bcl-6 (Bcl-2 and Bcl-6 immunohistochemical stains, 200x magnification). The overall morphological and immunophenotypic findings support the diagnosis of follicular lymphoma.
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IIIA (Figure 2). Immunohistochemical stains showed predominantly CD20(+)/Pax-5(+) B cells that were reactive for both Bcl-2 and Bcl-6 (Figure 3).