PMC3880721_01
Lung lobectomy: hematoxylin and eosin stain of the pathologic specimen from left upper lobectomy showing poorly differentiated adenocarcinoma, H&E.
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fig1
Histopathological examination of the tumor confirmed poorly differentiated adenocarcinoma (Figure 1).
Neck CT: A reveals a large heterogeneous mass that has replaced the left lobe of the thyroid gland.
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fig2
Neck computed tomography (CT) showed interval enlargement of a heterogeneously enhancing mass in the left thyroid lobe (Figure 2).
Fine needle aspiration of the thyroid mass FNA, ThinPrep shows clusters of cancer cells with large nuclei and prominent nucleoli, consistent with metastatic lung adenocarcinoma.
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fig3
TTF-1 and negative for thyroglobulin, consistent with metastatic disease from lung origin (Figure 3). The patient was evaluated for thyroidectomy; nevertheless, because of the presence of positron emission tomography (PET) positive mediastinal lymph nodes that were hypermetabolic (Figure 4), she was deemed a nonsurgical candidate.
Fused fluorodeoxyglucose (FDG) positron emission tomography (PET) CT shows hypermetabolic left supraclavicular lymphadenopathy (yellow).
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fig4
TTF-1 and negative for thyroglobulin, consistent with metastatic disease from lung origin (Figure 3). The patient was evaluated for thyroidectomy; nevertheless, because of the presence of positron emission tomography (PET) positive mediastinal lymph nodes that were hypermetabolic (Figure 4), she was deemed a nonsurgical candidate.