PMC4063997_01
Three generation pedigree of family A. Bladder cancer shown as shaded. - indicates other cancer.
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Fig1
No parental siblings had a history of any relevant cancer (Figure 1).Family B.
Four generation pedigree of family B. Bladder cancer shown as shaded. - indicates other cancer.
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Fig2
The proband's daughter III.1 developed stage III bladder cancer aged 76, a son III.6 was diagnosed with stage II UCC bladder at age 50 (also a HFE gene carrier) a daughter III.4 (a smoker) developed lung cancer at age 65, and a son III.5 developed colon cancer at age 60 (Figure 2).