PMC8302384_01
Histological appearance of the tumour. Giant cell urothelial carcinoma comprising sheets of pleomorphic cells with admixed bizarre mononuclear and multinuclear giant cells ((a), haematoxylin and eosin x400) which were positive for pancytokeratin ((b), AE1/AE3 x400) admixed with areas of conventional urothelial carcinoma (c) and carcinoma in situ (d).
CRIU2021-8021947.001.jpg
PMC8302384_01_CRIU2021-8021947.001.jpg
fig1
Admixed bizarre mononuclear and multinuclear giant cells were seen (Figure 1(a)). The giant cells were positive for pancytokeratin (AE1/AE3) (Figure 1(b)). Areas of conventional urothelial carcinoma (Figure 1(c)) with overlying carcinoma in situ were present (Figure 1(d)).