PMC6390639_01
A/B: Gray scale (GS) ultrasound images showing alleviation of metacarpophalangeal synovitis in Case 1 with certolizumab pegol: (A) Pre treatment (Day 0): GS3; (B) Post certolizumab pegol treatment (Day 90): GS0. C/D: Ultrasound B-mode color map images showing alleviation of metacarpophalangeal synovitis in Case 2 post certolizumab pegol: (C) Pre treatment (Day 0): GS2; (D) Post certolizumab pegol treatment (Day 90): GS0.
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The patient was subjected to articular ultrasound in June 2016, with active disease diagnosed (Figure 1, panel C). Figure 1 shows B-mode color map ultrasound images of the alleviation of metacarpophalangeal synovitis following 3 months of certolizumab pegol treatment. Ultrasound detected GS improvements, from GS2 to GS0, in the right wrist, right second and third metacarpophalangeal joints, and right third proximal interphalangeal joint (Figure 1, panels C and D).
Spectral Doppler images of the right hand in Case 1, pre and post certolizumab pegol: (A) Pre treatment (Day 0) with resistance index (RI) = 0.53; (B) Post certolizumab pegol treatment (Day 90) with RI = 0.78.
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Figure 2 shows spectral Doppler images of the right hand pre and post certolizumab pegol, with improvement in the right wrist resistance index (RI) from 0.53 to 0.78.
PMC6390639_02
A/B: Gray scale (GS) ultrasound images showing alleviation of metacarpophalangeal synovitis in Case 1 with certolizumab pegol: (A) Pre treatment (Day 0): GS3; (B) Post certolizumab pegol treatment (Day 90): GS0. C/D: Ultrasound B-mode color map images showing alleviation of metacarpophalangeal synovitis in Case 2 post certolizumab pegol: (C) Pre treatment (Day 0): GS2; (D) Post certolizumab pegol treatment (Day 90): GS0.
dic-8-212554-g001.jpg
PMC6390639_02_dic-8-212554-g001.jpg
f1-dic-8-212554
The patient was subjected to articular ultrasound in June 2016, with active disease diagnosed (Figure 1, panel C). Figure 1 shows B-mode color map ultrasound images of the alleviation of metacarpophalangeal synovitis following 3 months of certolizumab pegol treatment. Ultrasound detected GS improvements, from GS2 to GS0, in the right wrist, right second and third metacarpophalangeal joints, and right third proximal interphalangeal joint (Figure 1, panels C and D).