PMC4125421_01
A photomicrograph of the EMR specimen. A type 0-IIc lesion with a well-differentiated adenocarcinoma with negative lymphovascular involvement was found (hematoxylin and eosin stain). The scale bar is indicated.
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Endoscopic mucosal resection (EMR) was finally performed three months after the referral, confirming that the neoplastic tissue was of type 0-IIc based on the Paris endoscopic classification of superficial neoplastic lesions, with a well-differentiated adenocarcinoma (Fig. 1), 7 x 6 mm in size.
The renal biopsy findings. (A) A low power view showing the diffuse distribution of glomeruli with various stages of diabetic glomerular injuries, including glomeruli with hyalinotic lesions (narrow arrow), a moderate increase in mesangial matrix and thickening of the capillary wall (medium arrow), as well as nodule formation (wide arrows) (periodic acid-Schiff stain). Two sections of the same glomerulus with nodular lesions (B) and enormous exudative lesions with some bubbles, probably representing plasma proteins/lipids (C) (upper panel, periodic acid-Schiff stain; lower panel, periodic acid methenamine silver-Masson trichrome stain). The scale bar is indicated in each panel.
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There were glomeruli with hyalinotic lesions, globally widened mesangial regions, and a number of rounded acellular mesangial nodules; and also interstitial infiltration of lymphocytes, atrophic changes in the tubule structure, interstitial fibrosis, and arteriolar hyalinization were identified (Fig. 2).