PMC5843127_01
Clinical features of NF 1, with numerous neurofibromata (a), big plexiform neurofibroma over the right side of the face (b) and (c) CT image showing several hypodense lesions in the liver parenchyma, suggestive of metastases. Source: Photographs of Patient and CT Abdomen taken by Juliane Hiesgen with the patient's consent
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On admission, she was moderately dehydrated with features of NF1 (Figures 1a and 1b). Abdominal ultrasound demonstrated several solid, round lesions in the liver that were confirmed on computed tomography (Figure 1c).
Histological slides from liver lesions: (a) HE staining showing polyglandular tumour cells with granular eosinophilic cytoplasm and glandular formation and (b) strongly positive immuno-histochemical synaptophysin stain (specific for neuroendocrine tumours).
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Special somatostatin staining was positive, proving the somatostatinoma (Figure 2a and 2b).