PMC6277135_01
Hematoxylin and eosin (H&E) stain of a 10-cm colon biopsy (20x) showing mild active colitis with occasional intraepithelial neutrophils in a background of intraepithelial lymphocytosis (arrows) and chronic interstitial inflammation.
CG-CGCR180063F001.jpg
PMC6277135_01_CG-CGCR180063F001.jpg
F1
Dysplasia surveillance biopsies throughout the colon revealed mild active colitis at 10 cm (Figure 1).
(A and B) H&E stain of a 70-cm colon biopsy (20x) showing lymphocytic colitis with surface epithelial injury associated with lymphocytic infiltration (arrows), loss of mucin, and scattered eosinophils. There is no thickened subepithelial collagen, which distinguishes lymphocytic colitis from collagenous colitis. (C) H&E stain of a 30-cm colon biopsy (20x) showing lymphocytic colitis with abundant subepithelial plasma cells. Arrows indicate intraepithelial lymphocytes.
CG-CGCR180063F002.jpg
PMC6277135_01_CG-CGCR180063F002.jpg
F2
Biopsies at 30 cm and 70 cm showed LC (considered an active colitis) with chronicity, lymphocytes, and plasma cells; the presence of lymphocytes and plasma cells indicated chronic inflammation (Figure 2).