PMC9384868_01
Orange-yellow plaque with overlying scattered 2 mm whiteish blisters on the right zygomatic area.
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Physical examination revealed a 2x2 cm oval-shaped, well-demarcated, orange-yellow plaque with overlying scattered 2 mm whiteish blisters on the right zygomatic area (Figure 1).
Three pathological images of nodular amyloidosis. (A) Deposition of acellular amorphous eosinophilic materials over the entire dermis and subcutis (H&E, x200). (B) The amyloid deposits were positive for Congo red staining, and keratinous cysts were found in the superficial dermis. The arrows indicate the sites of amyloid deposits.(Congo red staining, x200) (C) The amyloid deposits were positive for crystal violet staining, and keratinous cysts were found in the superficial dermis. The arrows indicate the sites of amyloid deposits. (Crystal violet staining, x200).
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Histopathologically, the overlying epidermis showed atrophic changes, and lymphocytes and plasma cells were found in the superficial dermis and around the blood vessels (Figure 2A). The entire dermis and subcutis were filled with eosinophilic, amorphous, and homogeneous amyloid material that was positive for Congo red and Crystal violet staining (the arrows in Figure 2B and C represent the sites of amyloid deposition). Some keratin cysts were found in the superficial dermis (Figure 2B and C).