PMC9059076_01
Clinical course of this case. IS international scale, MMR major molecular response, PE pleural effusion, TRPG tricuspid regurgitation pressure gradient, NT-proBNP N-terminal pro-brain natriuretic peptide.
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TKIs, except for hypertension and diabetes mellitus well-controlled by medications. The patient had normal findings on chest radiography, 12-lead electrocardiography (ECG), and ultrasonic echocardiography (UCG) (Supplementary Figure S1A-C). Chest radiography revealed right central pulmonary artery dilation without heart enlargement and PE (Figure S1D). A newly negative T wave at V1-V4 on a 12-lead ECG was observed (Figure S1E). Additionally, UCG revealed a dilated right ventricle with flattening of the interventricular septum, a small amount of pericardial effusion, and an elevated peak tricuspid regurgitation pressure gradient (TRPG; 77 mmHg) (Figure S1F). NT-proBNP levels returned to normal approximately 3 months after dasatinib cessation (Figure S1G-I). TRPG and NT-proBNP levels decreased to 42 mmHg and 86 pg/mL, respectively, although a dilated right ventricle remained on UCG (Figure S2G-I). The clinical course of this case is shown in Fig. 1.