PMC5646288_01
Haematoxylin and eosin stain of biopsy specimen revealed necrotizing granulomatous inflammation with small, round-oval budding yeast forms with narrow-based budding.
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fig1
The biopsy was collected in formalin and the haematoxylin and eosin stain revealed necrotizing granulomatous inflammation with small, round-oval budding yeast forms with narrow-based budding (Figure 1).
Grocott methenamine silver (GMS) stain of the same biopsy specimen as in Figure 1.
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fig2
Although definitive identification could not be performed on paraffin fixed tissue, the presence of ovoid, GMS-positive yeast 2 microm to 4 microm in diameter with single, narrow-based buds was consistent with Histoplasma capsulatum (H capsulatum) (Figure 2).