PMC9585235_01
Muscle biopsy pathology analysis demonstrated chronic inflammatory cell infiltration in striated muscle tissue (HE stains, original magnificationx100) (A). MGT (B). MHC-I (small peribundle fiber upregulation) (C). MAC-1 (non-necrotic fiber membrane deposition) (D).
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Muscle biopsy showed that the patient had striated muscle tissue with chronic inflammatory cell infiltration, and immunohistochemistry confirmed inflammatory myopathy, and the immunophenotypes were CD4(-), CD8(-), CD68(-), CD20 (weakly positive), MxA(-), MAC(+), p62(-), Dysferlin(+), R-Dystrophin(+) ( Figure 1 ).
Subcutaneous limb nodules of both lower limbs (A). Subcutaneous limb nodules of right upper limb (B).
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Figure 2 ). Further subcutaneous nodule pathological biopsy was confirmed as extranodal NK/T cell lymphoma (nasal type), and the immunophenotype was CD20(-), CD3(+), CD5(-), CD10(-), CD79a(-), CD43(+), Ki-67 (80%+), CD56 (diffuse strong +), EBER (partial +), GranzymeB(+),
The pathology of subcutaneous nodule biopsy suggested diffuse infiltration of heterogeneous lymphoid cells in adipose tissue (HE stains, original magnifcationx100) (A). CD56 (diffuse and strong +) (B). TIA-1 (+) (C). Granzyme B (+) (D). EBER (partial +) (E). CD3 (+) (F).
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TIA-1(+), P53 (partial +), CD2(+), CD4(-), CD7(+), CD8(-), CD21(-), CD23(-), Bcl-2(-), Bcl-6(-), and C-Myc (20%+) ( Figure 3 ).