PMC10289051_01
The head MRI scan. Contrast-enhanced flat mass in the lateral part of the right eyeball (arrow) on the T1 post-contrast image.
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At the beginning of diagnosis, an MRI scan revealed a 10 x 10 x 4.7 mm size flat mass in the lateral part of the right eyeball on the T1 post-contrast image without any signs of transbulbar growth and soft tissue invasion out of the eyeball (Figure 1).
The abdominal MRI. Hyperintense lesion in segment 6 of the liver (arrow) on diffusion-weighted imaging - progression.
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The abdominal MRI scan and PET CT showed a 20.9 x 16 mm liver lesion in S6 (Figure 2).
Microscopical aspects of melanoma. A. The tumor is composed of epithelioid cells with eosinophilic cytoplasm, polymorphic, hyperchromatic nuclei, and focally conspicuous nucleoli (HE, x50); Immunohistochemistry tests showed tumor cells positive for: B. Melan-A (anti-Melan-A Ab, x50), C. MiTF (anti-MiTF Ab, x50) and D. SOX-10 (anti-SOX-10 Ab, x100).
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Pathological examination identified a tumor composed of epithelioid cells with eosinophilic cytoplasm, polymorphic, hyperchromatic nuclei, and focally conspicuous nucleoli (Figure 3). SOX-10 (Figure 3); negative for PanCK (AE1/AE3). Systemic examination did not reveal other metastases.