PMC10264634_01
Well-defined, skin-colored, nodular lesion beneath the left mandible.
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F1
Examination showed a 15 mm round, well-defined, non-tender, skin-colored nodular lesion, with a slightly depressed center (Figure 1).
In high power magnification (10 x magnification-H & E stain), the cells have abundant eosinophilic granular cytoplasm with a small nucleus within a collagenous stroma.
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F2
Immediately adjacent to and beneath, this is an area of tumor proliferation comprised of cubes, sheets, and arches of large cells with small, round nuclei, central nuclei with an abundant eosinophillic, granular cytoplasm (Figures 2, 3).
Cutaneous fragment with central fibrosis in the dermis, aside from this fibrous tissue, there is a non-encapsulated tumor proliferation with irregular borders and perineural extension (10 x magnification-H & E stain).
fmed-10-1149735-g0003.jpg
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F3
Immediately adjacent to and beneath, this is an area of tumor proliferation comprised of cubes, sheets, and arches of large cells with small, round nuclei, central nuclei with an abundant eosinophillic, granular cytoplasm (Figures 2, 3).
S100 stain in granular cell tumor strongly stains the cytoplasm and the nuclei of the granular cells. Strong and diffuse S100 expression is characteristic of this tumor (40 x magnification).
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F4