PMC5438830_01
Liver biopsy. (a) Hematoxylin and eosin x20: liver biopsy specimen showing lobular disarray with numerous apoptotic hepatocytes (arrows) and increased sinusoidal inflammatory cells. No steatosis or frank necrosis is present. (b) Hematoxylin and eosin x40: liver biopsy specimen showing lobular disarray, prominent apoptotic hepatocytes, and biliary stasis, compatible with recent drug induced liver injury.
CRIOG2017-3547242.001.jpg
PMC5438830_01_CRIOG2017-3547242.001.jpg
fig1
ALT peaked at 3168 U/L. Alkaline phosphatase and total bilirubin remained within normal limits. A liver biopsy showed acute hepatitis with prominent apoptotic hepatocytes, cholestasis, and increased sinusoidal inflammatory cells (Figure 1).