PMC5356152_01
Upper GI endoscopy demonstrating severe inflammation of the (A) body and (B) antrum of the stomach, with significant erythema, erosions, and friability of the involved mucosa.
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F1
Upper GI endoscopy revealed severe inflammation of the entire examined stomach, with mucosal erosions and erythema and without ulceration or mass lesions (Figure 1).
Hematoxylin and eosin staining of gastric antrum tissue demonstrating severe chronic mucosal inflammation and occasional enlarged cells with prominent intracellular inclusions (arrowheads).
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F2
Microscopic examination of hematoxylin and eosin-stained tissue showed a chronic inflammatory infiltrate and nuclear enlargement of the glandular epithelial cells consistent with reactive changes (Figure 2).
Immunohistochemical staining for CMV shows strong nuclear reactivity among the enlarged cells.
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F3
Immunostaining for CMV was positive, while it was negative for herpes simplex virus and Helicobacter pylori (Figure 3).