PMC5625662_01
Muscle biopsy (thigh). Myofibers are swollen and hypereosinophilic (arrow) and some myofibers are fragmented (arrowheads)
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Fig1
The histopathologic results of skin biopsies from pigmented areas of forehead and nose revealed brown-black granules in the basement membrane of sweat gland epithelium that measured less than 1.0 um in diameter, which are diagnostic findings of argyria (Fig. 1).
Brown to black granules lining the basement membrane of sweat gland epithelium (arrow, H&E, X200)
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PMC5625662_01_40557_2017_201_Fig2_HTML.jpg
Fig2
We reviewed outside pathology slides obtained from the left thigh muscles and found markedly degenerated myofibers with disorganization of myofibrils without inflammatory reactions, consistent with unspecified myopathy, rather than inflammatory myopathy (Fig. 2).