PMC3447224_01
Pedigree. *Affected individual detected. B: balanced translocation detected; 46, X, t(X;18)(q22.3;q23). U: Unbalanced translocation detected; 46, X, der(X), t(X;18)(q22.3;q23). D: donor:individual 2 : 4 carried pregnancy 3 : 4 using donor egg (from individual 2 : 5) and partner's sperm (from individual 2 : 3). P: Pregnancy resulted from donor egg (from individual 2 : 5). SAB: spontaneous abortion (individual 3 : 3). NAD: no abnormalities detected.
CRIM.GENETICS2012-681747.001.jpg
PMC3447224_01_CRIM.GENETICS2012-681747.001.jpg
fig1
The proposita is the second of three siblings (Figure 1; individual 2 : 4), conceived when the mother was 21 years of age.
PMC3447224_02
PMC3447224_03