PMC5477899_01
Diagram of the in vitro dialysis experiment showing the location of partial occlusion of the blood lines. (A) Kinking of line proximal to the arterial pressure monitor causes immediate increase in negative pressure to below -250 mmHg. The machine alarms and cannot be overridden without correction of the kink. (B) Kinking of the tubing between the blood pump an the venous pressure monitor including the connecting segment between the two dialysers causes drop in positive venous pressure to approximately 15 mmHg indicating low blood return to patient. The machine alarms but can be overridden. (C) Kinking of the tubing distal to the venous pressure monitor causes immediate increase in venous pressure to above 250 mmHg. The machine alarms and cannot be overridden without correction of the kink.
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F1
We subsequently performed a controlled in vitro dialysis experiment to evaluate the effect of partial occlusion of blood lines at various sites, using saline and tandem dialyzers (Figure 1).