PMC10449246_01
Gross view and measure of the coronary arteries after fixation (B, C, and D). A - thinned out proximal left anterior descending artery of the fresh heart during the autopsy; B - left anterior descending artery measuring the diameter of 1.29 mm; C - left circumflex artery measuring the diameter of 1.19 mm.
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All coronaries were thinned out, with narrowed luminal diameters (Figure 1A). The left anterior descending artery's diameter was 1.29 mm (Figure 1B), the left circumflex artery was 1.19 mm (Figure 1C), right coronary artery was 1.02 mm when measured 1 cm away from their respective origins.
Photomicrographs of the coronary arteries A, B, and C - shows the left anterior descending artery with thin tunica media (A - Masson Trichrome stain, 4X; B - Verhoeff's Elastic stain 4X; C - Verhoeff's Elastic stain, 10X).
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The muscular layer was missing and underdeveloped in the left anterior descending (Figure 22B and 2C) and left circumflex arteries (Figure 3A). The tunica media or muscle layer was thin and absent at places along the vessels' wall, evidenced by the Masson trichrome staining and Verhoeffs stain in left anterior descending artery (Figure 2A, 2B and 2C).The right coronary artery showed normal arterial wall histology (Figure 3B).
Photomicrographs of the coronary arteries. A - shows the left circumflex artery with a thin vessel wall surrounded by the cardiac muscle (Masson trichrome stain, 20X); B- histologic cross-section of coronary artery showing normal tunica intima, the thickness of tunica media, and tunica adventitia of the right coronary artery (Masson trichrome stain).
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The muscular layer was missing and underdeveloped in the left anterior descending (Figure 22B and 2C) and left circumflex arteries (Figure 3A). The tunica media or muscle layer was thin and absent at places along the vessels' wall, evidenced by the Masson trichrome staining and Verhoeffs stain in left anterior descending artery (Figure 2A, 2B and 2C).The right coronary artery showed normal arterial wall histology (Figure 3B).
Photomicrographs of myocardial muscle: A - shows the separation of myocardial fibers and edema (H&E, 4X); B and C - show inflammatory cells comprising of macrophages and lymphocytes in between myocardial fibers (H&E, B-40X, C-100X).
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The myocardium examination showed evidence of recent myocardial infarction represented by myocardiocytes interspersed by edema (Figure 4A), and early neutrophilic infiltration (Figure 4B) with reactive nuclei of myocardium (Figure 4C).