PMC4697093_01
Chest computed tomography scan in lung window shows a well-circumscribed large solid mass.
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A computed tomography (CT) scan confirmed the presence of a solid mass measuring 14 x 7.5 x 9 cm occupying the fissure between the right middle and lower lobe (Figure 1).
Large homogenous solid mass completely resected (macroscopic view).
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The mass increased in size by 75% compared with a CT scan performed a year earlier (Figure 2).
The spindle cells show strong and diffuse positivity for CD34. x100 magnification.
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The right lung was fully mobilised and the mass completely excised and sent for histological analysis (Figure 3).
The spindle cells show strong and diffuse positivity for Bcl-2. x100 magnification.
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Areas of hypercellularity, nuclear atypia, 18 mitoses per 10 high-power fields, and haemorrhagic and necrotic transformation were also identified, which confirmed that malignant transformation of a benign tumour had occurred (Figures 4, 5, and 6).
Tumour showing areas of hypocellularity and dense collagenous stroma. x200 magnification.
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fig5
Areas of hypercellularity, nuclear atypia, 18 mitoses per 10 high-power fields, and haemorrhagic and necrotic transformation were also identified, which confirmed that malignant transformation of a benign tumour had occurred (Figures 4, 5, and 6).
Spindle cells show marked nuclear atypia, overcrowding, and brisk mitotic activity. x400 magnification.
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fig6
Areas of hypercellularity, nuclear atypia, 18 mitoses per 10 high-power fields, and haemorrhagic and necrotic transformation were also identified, which confirmed that malignant transformation of a benign tumour had occurred (Figures 4, 5, and 6).