PMC8079193_01
Scrotal ultrasound.
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An ultrasound was requested, showing a heterogeneous left testicle with small rounded hypoechoic areas, increased blood flow, and small echogenic foci along the rete testis with moderate left hydrocele (Figure 1).
Gross specimen testicular tumor.
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A separate, well-demarcated, nearly round tumor nodule was present in the head of the epididymis (Figure 2).
Esophageal tissue (left): sheets of neoplastic cells with high nucleus/cytoplasm ratio and nuclear hyperchromasia and pleomorphism. Immunohistochemical staining was positive for monoclonal CEA and negative for p63, synaptophysin, and chromogranin, supporting a diagnosis of poorly differentiated adenocarcinoma (H&E; x12.5). Testicular tissue (right): poorly differentiated and loosely cohesive carcinoma with predominantly solid and some focal glandular architecture demonstrating considerable pleomorphism. Adjacent seminiferous tubule (H&E; x10).
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Histologically, the tumor in the testis was markedly similar to that in the esophagus, with both showing a majority solid growth pattern and focal glandular differentiation (Figure 3).