PMC5320374_01
G-banded metaphase cell with 9/22 translocation (arrows indicate derivative chromosome 9 and 22 products).
CRIHEM2017-7815095.001.jpg
PMC5320374_01_CRIHEM2017-7815095.001.jpg
fig1
Bone marrow cytogenetics revealed 46,XY,t(9,22)(q34;q11.2) [19/20]/46,XY [1/20] (Figure 1).
(a) BCR/ABL1 dual fusion positive interphase nucleus; (b) BCR/ABL 1 and ABL/BCR positive metaphase cell (arrows indicate fusion products); (c) and (d) IgH/CCND1 dual fusion positive interphase nuclei (arrows indicate fusion products).
CRIHEM2017-7815095.002.jpg
PMC5320374_01_CRIHEM2017-7815095.002.jpg
fig2
DAPI staining and a total of three hundred metaphase cells were microscopically analyzed for each probe set employed. Dual-color FISH images were digitally generated utilizing computer-imaging software (Figures 2(a)-2(d)).