PMC8790034_01
Upper quadrants: bone marrow morphology at diagnosis. Lower quadrants: bone marrow morphology after imatinib treatment (3 months). Left quadrants: Giemsa stain. Right quadrants: tryptase stain with CD117 immunohistochemistry (insert).
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MDS/MPN and BM fibrosis grade (MF-1) (Figure 1). Mast cells decreased up to 1-2%, serum tryptase level on peripheral blood remained within normal range and spleen diameter decreased up to 16 cm.