PMC10232891_01
Brain MRI in the patient and a healthy control subject (the same age girl). (A) Sagittal T1-weighted image showing thin corpus callosum (white arrow) in the patient, compared to normal corpus callosum morphology in a control subject. (B) Axial FLAIR image showing typical "ears of the lynx" sign (white arrow). (C) Brain image in the healthy control subject.
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F1
Magnetic resonance imaging (MRI) of the brain revealed a markedly thin CC, particularly in the genu and anterior portion of the body, best seen on sagittal T1-weighted image (Figure 1A). Axial FLAIR image (Figure 1B) showed the focal thinning in the genu fibers of the CC, which is referred to as the "ears of the lynx" sign and is a highly correlated imaging presentation with SPG11-HSP. The center of the figure-8-shaped coil was placed 1 cm posterior to the vertex and 1-2 cm laterally on the target hemisphere.
(A) The CSTs of the patient (pre-treatment and post-treatment) and a healthy subject (the same age girl). White arrows are used to highlight the differences. The DTI revealed thinning of the CSTs in bilateral hemispheres compared to those of a healthy control subject. (B) The FA values from CC and CST of the patient (pre-treatment and post-treatment) and the healthy subject. (C) The MD values from CC and CST of the patient (pre-treatment and post-treatment) and the healthy subject. (D) The RD values from CC and CST of the patient (pre-treatment and post-treatment) and the healthy subject. CC, corpus callosum; CST, corticospinal tract; FA, fractional anisotropy (10-3 mm2/s); MD, mean diffusivity (10-3 mm2/s); RD, radial diffusivity (10-3 mm2/s); R, right; L, left.
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F2
As shown in Figure 2, DTI revealed thinning of the CSTs in bilateral hemispheres compared to those of a healthy control subject.