PMC2864358_01
PMC2864358_02
Kidney biopsy findings for case 2. A. Photomicrograph of biopsy demonstrating the pattern of focal segmental glomerulosclerosis, collapsing variant. Note that collapsed lobules retain their individuality and are associated with hypertrophied/hyperplastic podocytes with intracytoplasmic vacuoles (arrow) some of which contain protein reabsortion droplets. (PAS stain. Original magnification 400X).. B. Electron micrograph of biopsy. Note the prominent mesangial immune complex-type electron-dense deposits (arrow). (Uranyl acetate- Lead citrate. Original magnification 3300X).
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F1
Immunofluorescence microscopy revealed segmental mesangial deposits: IgG (2+), IgM (0.5+), and C1q (4+). electron microscopic examination confirmed the presence of massive mesangial immune complex-type electron-dense deposits without endothelial tubuloreticular inclusions (Figure 1).