PMC10172687_01
Course of the complete regression of the patient's multiple liver metastases. (A) MR/CT scans of the patient's liver before and after partial PRISI and treatment with the low-dose metronomic TMZ regimen. (B) Diagram showing the progressive change in the size of tumor lesions. Lesion numbers labeled on scans correspond to the same lesion numbers in the diagram. PRISI, permanent radioactive iodine-125 seeds implantation; TMZ, temozolomide.
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His disease progressed and, after treatment with two cycles of EP and one cycle of single paclitaxel chemotherapy, a MR scan revealed multiple liver metastases ( Figure 1A , 2016-02-16). The patient's liver metastases significantly progressed, with two masses measuring > 50 mm in diameter and five metastases > 20 mm in diameter: individually, 50.91mm, 47.75mm, 52mm, 30.58mm, 39.86mm, 35.26mm, 22.61mm in diameter ( Figures 1A, B , 2016-06-20). We implanted 38 seeds in the dorsal lesion and 26 seeds in the ventral lesion ( Figures 1A , 2016-07-06). The remaining two lesions had achieved partial response (PR), shrinking in diameter in one case from 52.86 mm to 12.62 mm and in the other case from 65.92 mm to 16.69 mm ( Figures 1A, B , 2016-12-29, 2017-04-07). Figure 1 , 2017-08-02). Follow-up results 13-15 months post PRISI therapy showed continued CR of liver metastases ( Figures 1A, B , 2017-08-02 and 2017-10-10).