PMC3995396_01
Skin biopsy revealed large malignant lymphoid cells with eosinophilic nucleoli in the vessels of the subcutaneous tissue (HE. a x100; b x400). The tumor cells in the vessels are highlighted by immunohistochemical staining for CD20 (c x400).
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F1
Histological examination revealed atypical cells lodged in the intravascular lumens in the subcutaneous tissue of the normally appearing left thigh region (fig. 1a). Higher magnification revealed vessels filled with large malignant lymphoid cells and eosinophilic nucleoli (fig. 1b); the cells were stained with CD20 antibodies but not with CD3 (fig. 1c).
Brain MRI in the 7th (a-c) and 9th (d-f) week after admission. FLAIR and DWI show a mass involving the right basal ganglia and thalamus (a, b). The mass was clearly enhanced (c). Two weeks later, the mass had enlarged (d-f).
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F2
An MRI obtained 7 weeks after admission showed a mass lesion involving the right basal ganglia, thalamus, corona radiata, uncus, and crus cerebri (fig. 2). T1-weighted image, hyperintense on a T2-weighted image, and exhibited mild restricted diffusion on a diffusion-weighted image (DWI). The mass was homogeneously enhanced (fig. 2). An MRI obtained 9 weeks after admission showed an enlargement of the mass (fig. 2).