PMC2685226_01
A) Right eye: Color fundus picture showing slightly dilated right-angle veins with retinal pigment epithelium hyperplasia beneath them. B) Left eye: Color fundus picture showing subretinal hemorrhage inferior and temporal to the fovea. C) Venous phase of FA of the LE depicts early hyperfluorescence corresponding to the neovascular membrane and hypofluorescence inferior to the membrane corresponding to the subretinal hemorrhage. D) Late phase of FA showing leakage from the neovascular membrane.. Abbreviations: FA, fluorescein angiography; LE, left eye; OCT, optical coherence tomography.
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Fundus biomicroscopy revealed in the right macula, slightly dilated right-angle veins with RPE hyperplasia beneath them (Figure 1A). In addition to these findings, in the left macula there was subretinal hemorrhage (Figure 1B). Fluorescein angiography (FA) and optical coherence tomography (OCT) were performed and confirmed the above diagnosis (Figures 1C-D, 2, 3A).
Oblique section of OCT of the LE.. Abbreviations: LE, left eye; OCT, optical coherence tomography.
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Fluorescein angiography (FA) and optical coherence tomography (OCT) were performed and confirmed the above diagnosis (Figures 1C-D, 2, 3A).
A) Oblique section of OCT of the LE revealing the characteristic appearance of outer and inner retina having similar reflectivity and an area temporal to the fovea with high reflectivity corresponding to the temporal area of choroidal neovascularization observed in the angiogram. B) OCT of the same section of LE revealing significant reduction in retinal thickness. The RPE remains thickened.. Abbreviations: LE, left eye; OCT, optical coherence tomography; RPE, retinal pigment epithelium.
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Fluorescein angiography (FA) and optical coherence tomography (OCT) were performed and confirmed the above diagnosis (Figures 1C-D, 2, 3A). OCT of the LE revealed the characteristic appearance of outer and inner retina having similar reflectivity and an area temporal to the fovea with high reflectivity corresponding to the temporal area of choroidal neovascularization (CNV) (Figure 3A), which was observed in the angiogram. FA and OCT which were performed monthly, the patient underwent three intravitreal injections of ranibizumab every month for three months. Following these injections, BCVA increased to 3/10 and both clinical and angiographic appearances showed significant improvement with minimal leakage in FA and absence of intra- or subretinal fluid in OCT and significant reduction in retinal thickness; the RPE remained thickened (Figures 3B, 4A-B).
A) Left eye: Color fundus picture following ranibizumab treatment revealing significant improvement with no subretinal hemorrhage. B) late venous phase of FA of the LE showing minimal leakage due to telangiectasis but no signs of active neovascular membrane.. Abbreviations: FA, fluorescein angiography; LE, left eye.
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FA and OCT which were performed monthly, the patient underwent three intravitreal injections of ranibizumab every month for three months. Following these injections, BCVA increased to 3/10 and both clinical and angiographic appearances showed significant improvement with minimal leakage in FA and absence of intra- or subretinal fluid in OCT and significant reduction in retinal thickness; the RPE remained thickened (Figures 3B, 4A-B).