PMC4458531_01
(a) Computed tomography (CT) of the thorax showed a well-defined enhancing soft tissue density lesion of size 10.3 x 9.3 cm involving superior mediastinum, with compression of trachea, SVC, right upper lobe bronchus, and its branches. (b) Histopathological examination of the biopsy specimen from the mediastinal mass was characterized by a monotonous proliferation of tumor cells with oval to spindle, vesicular nuclei surrounded by an indistinct rim of amphophilic to lightly eosinophilic cytoplasm. (c) Immunohistochemical image shows strong vimentin positivity. (d) Immunohistochemical image shows strong S-100 positivity.
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fig1
Contrast-enhanced computed tomography (CT) of the thorax showed an enhancing well-defined soft tissue density lesion of size 10.3 x 9.3 cm involving superior mediastinum, with compression of trachea, SVC, right upper lobe bronchus, and its branches (Figure 1(a)). Histopathological examination of the biopsy specimen was characterized by a monotonous proliferation of tumor cells with oval to spindle, vesicular nuclei surrounded by an indistinct rim of amphophilic to lightly eosinophilic cytoplasm (Figure 1(b)). Immunohistochemistry of the biopsied sample showed positive reactivity to vimentin (Figure 1(c)) and S-100 (Figure 1(d)), epithelial membrane antigen, cytokeratin AE1/AE3, bcl-2, and E-cadherin.