PMC4870479_01
a Clinical presentation at base-line; b LSR on day 4; c 15 days of follow-up; d 57 days of follow-up
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PMC4870479_01_40064_2016_2290_Fig1_HTML.jpg
Fig1
Physical examination showed multiple rough, dry, erythematous, scaly and raised bumps and patches that were 0.5-1.0 cm in size (Fig. 1a). LSR on day 4 was severe (Fig. 1b), with edema, erythema, confluent pustules, erosions, severe crusts and periorbital edema, but no additional treatment was required and the patient's adherence to treatment was not affected. The LSR had resolved completely after 15 days without scars (Campanati et al.) or skin color change, and healthy skin with complete AK clearance was achieved (Fig. 1c). Total clearance of AK lesions was observed after 57 days of follow-up without any sign of recurrence (Fig. 1d).
a Clinical presentation at base-line; b LSR on day 4; c 15 days of follow-up; d 57 days of follow-up
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PMC4870479_01_40064_2016_2290_Fig2_HTML.jpg
Fig2
Physical examination showed multiple erythematous macules, scaly and raised bumps, and brown patches (0.3-1.2 cm in size) on sun-damaged skin (Fig. 2a). LSR on day 4 was moderate (Fig. 2b), with edema, erythema, some pustules, mild erosion and a few crusts. The patient did not need any additional treatment and there was complete resolution of LSR after 15 days without sequelae, and skin photorejuvenation with complete AK lesion clearance was observed (Fig. 2c). AK lesions had disappeared on reassessment after treatment. At 57 days' follow-up, there was total clearance of AK lesions without signs of recurrence (Fig. 2d).
PMC4870479_02
a Clinical presentation at base-line; b LSR on day 4; c 15 days of follow-up; d 57 days of follow-up
40064_2016_2290_Fig3_HTML.jpg
PMC4870479_02_40064_2016_2290_Fig3_HTML.jpg
Fig3
Physical examination showed multiple, moderately thick erythematous scaly lesions and other signs of solar damage, such as solar elastosis (Fig. 3a). LSR on day 4 was mild (Fig. 3b), with application-site pruritus, very mild erythema, few pustules, some scales and crusts. Crusts persisted for the following 2 weeks (Fig. 3c), but all had disappeared within another week after that. There was total clearance of AK lesions after 57 days and no signs of recurrence (Fig. 3d).