PMC7475735_01
Photomicrographs of a breast metaplastic carcinoma. (a) Low magnification showing a solid trabecular tumor exhibiting keratin pearls and infiltrating the desmoplastic stroma (H&E, x40). (b) High magnification shows nests of cohesive, large polygonal cells with eosinophilic cytoplasm, and large nuclei with prominent nucleoli; necrosis and cavitation are seen on the right lower field (H&E, x200). (c) The tumor is negative for ER (immunoperoxidase, x200). (d) The tumor is negative for HER2/neu (immunoperoxidase, x200).
CRIPA2020-4806342.001.jpg
PMC7475735_01_CRIPA2020-4806342.001.jpg
fig1
The solid component showed squamous nests with keratinization, invading in desmoplastic stroma (Figure 1(a)). The tumor cells are large polygonal, with eosinophilic cytoplasm, large irregular nuclei, some of which showed prominent nucleoli (Figure 1(b)). Immunoperoxidase stains were negative for estrogen receptor (ER, Figure 1(c)) and HER2/neu (Figure 1(d)).