PMC3945261_01
Left: Non-enhanced CT scan - hypodense focal mass of 20mm in diameter with clear delimitation, situated in the tail of the pancreas; Right: Contrast-enhanced CT, arterial phase - there is no visible contrast enhancement of the tumoral mass
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F1
Right: B-mode linear EUS - hypoechoic mass of 20mm; Left: Elastography EUS - green color overlay consistent with soft (i.e. benign) tissue
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F2
B-mode ultrasound showed a hypoechoic focal mass of approximately 20mm in diameter with a cystic component, while elastography showed a predominantly green pattern, consistent with soft tissue, suggestive of a benign mass [Figure 2]. 
Power Doppler linear EUS and image analysis with ImageJ software - contrast enhancement can only be observed around the tumor, with low computed vascularity indexes. The cystic component can be seen in this incidence
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F3
FNA sample, H-E stain - Hypercellularity with moderate nuclear dyskariosis, atypical mitoses and frequent denudated dyskariotic nuclei
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F4
One of the two HE stain slides showed hypercellularity with frequent placards of round-oval cells, some pseudo-rosette-like, others with papillar distribution and moderate nuclear dyskariosis, atypical mitoses and frequent denudated dyskariotic nuclei [Figure 4]. 
FNA sample, IHC staining for chromogranin - intensely positive cytoplasm marking diffusely throughout the tumor
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F5
 IHC assay of the FNA material obtained the following results: chromogranin with intensely positive cytoplasm marking diffusely throughout the tumor [Figure 5], synaptophysin with positive diffuse cytoplasmatic marking [Figure 6], cytokeratin 7 absent in the tumor cells, cytokeratines AE1/AE3 positive in the paranuclear granule diffusely throughout the tumor cells, cytokeratine 20 and CEA were absent, protein Ki67 was absent (although the fragment was considered too small for an accurate assessment of this marker), protein p53 absent, CA 19-9 antigen weak positive focally inside the cells.
FNA sample, IHC staining for synaptophysin - diffusely positive immune marking of tumor cells
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F6
 IHC assay of the FNA material obtained the following results: chromogranin with intensely positive cytoplasm marking diffusely throughout the tumor [Figure 5], synaptophysin with positive diffuse cytoplasmatic marking [Figure 6], cytokeratin 7 absent in the tumor cells, cytokeratines AE1/AE3 positive in the paranuclear granule diffusely throughout the tumor cells, cytokeratine 20 and CEA were absent, protein Ki67 was absent (although the fragment was considered too small for an accurate assessment of this marker), protein p53 absent, CA 19-9 antigen weak positive focally inside the cells.