PMC7509434_01
Inflammatory cell infiltration of the small and large intestine in the patient with LRBA deficiency. Figure displays hematoxylin and eosin (H&E) stain at (A) x100 and (B) x400 of duodenal biopsies. The mucosa shows flattened villi and hyperplastic crypts, with an increase in plasma cells in the lamina propria. Crypt epithelium shows increased intraepithelial lymphocytes (arrows). Next, an H&E stain of the transverse colon is presented at (C) x100 and (D) x400. The structure of the colonic mucosa is preserved. The stroma is infiltrated by mononuclear inflammatory cells and the crypt epithelium shows increased intraepithelial lymphocytes (arrows), similar to the duodenal biopsy. The lamina propria shows increase in plasma cells.
fimmu-11-01775-g0001.jpg
PMC7509434_01_fimmu-11-01775-g0001.jpg
F1
Duodenal biopsies demonstrated villous atrophy and crypt hyperplasia, similar to that seen in celiac disease; however, increased intraepithelial lymphocytes were seen only in the crypt epithelium and not in the surface epithelium (Figures 1A,B). Colonic biopsies showed changes similar to those of the duodenal biopsies with increased intraepithelial lymphocytes in the crypt epithelium, but not in the surface epithelium, and an increase in plasma cells in the lamina propria (Figures 1C,D).