PMC2364178_01
Pharmacokinetics of 5-FU. Shown are 5-FU plasma levels observed in a patient with a IVS14+1G>A mutation in the DPYD gene (solid diamond) and the 5-FU plasma levels resulting from simulation of a normal renal function in the same patient. 5-FU plasma levels from control patients are depicted as mean+-s.d. (solid triangle; n=6).
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fig2
In all control patients the plasma level at t=90 min was below 0.1 mg l-1, whereas in the index patient the plasma level was still 3.8 mg l-1 at this time point (see Figure 2).