PMC5646290_01
Pigmented pleomorphic tumor cells in Case 1 (HEX 200).
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fig1
On histological examination pleomorphic tumor cells were arranged in syncytial pattern (Figure 1).
Presence of diffuse HMB45 expression (DABX 200).
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fig2
Tumor cells showed diffuse and strong expression of HMB45 (Figure 2), Melan A, and S-100 protein but were negative for Cytokeratin, CD56, Chromogranin, Synaptophysin.
PMC5646290_02
In T1-contrasted axial series, extraspinal extension of the tumor from the spinal canal through the neural foramen is seen.
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fig3
Magnetic resonance imaging (MRI) of lumbar spine revealed intradural extramedullary lesion measuring 6.1 x 2.0 cm at L1-2 level near the right kidney which was hypointense on T1- and hyperintense on T2-weighted sequences (Figures 3 and 4).
In T1-contrasted coronal series, dumbbell shape extraspinal extension of tumor is monitored.
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fig4
Magnetic resonance imaging (MRI) of lumbar spine revealed intradural extramedullary lesion measuring 6.1 x 2.0 cm at L1-2 level near the right kidney which was hypointense on T1- and hyperintense on T2-weighted sequences (Figures 3 and 4).
Panoramic appearance of tumor with infiltrative border (HEX 20).
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fig5
Histopathology revealed spindle cell tumor arranged in lobular pattern with infiltrative border (Figure 5).
Tumor of Case 2 is composed of mostly spindle cells (HEX 200).
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fig6
Tumor cells had distinctive nucleoli and melanin pigments in cytoplasm (Figure 6).
Presence of diffuse S-100 protein expression (DABX 200).
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fig7
Immunohistochemical staining for HMB45, Melan A, Vimentin, S-100 protein (Figure 7), Cytokeratin, EMA, Actin, Desmin, and Ki 67 was performed.