PMC10115524_01
Laryngoscopy findings at the initial examination showing elevated white lesions bilaterally on the vocal cords and subglottis.
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Endoscopic examination showed elevated white lesions bilaterally on the patient's vocal cords and subglottic mucosa (Figure 1).
Pathology findings of biopsy specimens. Hematoxylin-eosin staining showed inflammatory cell infiltration and spherical structures (a, b). Yeast-type fungi with capsules that tested positive with PAS and Grocott's staining were observed ((c) PAS staining and (d) Grocott's staining). Budding yeasts ( ) were also observed.
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Histological examination of a biopsy specimen obtained under local anesthesia at the time of the initial visit showed inflammatory cell infiltration and round fungal bodies (Figures 2(a) and 2(b)). Since these fungal bodies were stained with periodic acid-Schiff (PAS) and Grocott's staining (Figures 2(c) and 2(d)), cryptococcal infection was suspected.
Laryngoscopy findings after 6 months of treatment. The elevated lesions on both sides had disappeared.
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After 6 months of treatment, the lesions on the vocal cords and subglottic mucosa disappeared bilaterally (Figure 3).