PMC8812275_01
Pathomorphologic picture of the tumor shows (A). on HE examination epithelioid clear cancer cells with nuclear atypia forming papillary and tubular structures; (B) on IHC evaluation positive TFE3+ expression.
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Immuno-histochemical (IHC) evaluation showed that the tumor was CD10+, vimentin+, TFE3+, and CK7- ( Figure 1 ), which led to the final diagnosis of TRCC further confirmed as the Xp11 translocation subtype by fluorescence in situ hybridization (FISH) at the pathological stage T3aNxM1 (according to the TNM classification of malignant tumors, 8th edition).
CT scan shows (A) the neoplastic thrombus almost completely obstructing inferior vena cava from L2/L3 to the right atrium; (B) perfusion changes in the liver.
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Neoplastic thrombus almost completely obstructed inferior vena cava from L2/L3 to the right atrium with by-pass circulation below and above the diaphragm and perfusion changes in the liver ( Figure 2 ).