PMC6514521_01
a Core of liver mass in a patient with multiple liver lesions, pancreas mass, and diarrhea. Histology shows trabecular architecture of uniform cells with pale-pink cytoplasm and round, eccentrically located nuclei, consistent with well-differentiated PNET. H&E. x200. b Synaptophysin, diffusely and strongly positive in tumor cells (x200). c Chromogranin, apical positivity with moderate intensity (x200). d Ki-67 highlights proliferation index of 2%. H&E. x200.
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F1
PET-CT to help guide therapy. Pathology of the liver aspiration showed a proliferation index (Ki-67) of 2%, which is consistent with a well-differentiated neuroendocrine tumor (Fig. 1).