PMC5059539_01
Case #1 of a 71-year-old man. Anterior and posterior bone scan, and CT at baseline (a, b, c), within 3 months after completion of Radium-223 (d, e, f), and 6-12 months after Radium-223 (g, h, i). Imaging findings are summarized in Table 1.
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PMC5059539_02
Case #2 of a 65-year-old man. Anterior and posterior bone scan, and CT at baseline (a, b, c), within 3 months after completion of Radium-223 (d, e, f), and 6-12 months after Radium-223 (g, h, i). Imaging findings are summarized in Table 2.
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The patient died 19 months after Radium-223 therapy with progressive bone metastasis as well as visceral metastases and lymphadenopathy (Figure 2, Table 2).
PMC5059539_03
Case #3 of a 67-year-old man. Anterior and posterior bone scan, and CT at baseline (a, b, c) and within 3 months after completion of Radium-223 (d, e, f). Imaging findings are summarized in Table 3.
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Hb 8.5 mg/dL within three months of completion of Radium-223 and was found to have progressive disease involving the bone, liver, lymph nodes, lungs, and brain (Figure 3, Table 3). He was then treated with low-dose, daily cyclophosphamide (Cytoxan) and degarelix (Firmagon) but died five months after Radium-223 therapy.