PMC5439255_01
Clinical presentation of the patient; blisters, erosions, and remnants of blisters on her breasts and abdomen.
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A 26-year-old woman with mycosis fungoides developed blisters while receiving 8-methoxypsoralen and ultraviolet A (PUVA) therapy, at session 17 when the dose of UVA was 7.01 J/cm2 (cumulative dose was 70.66 J/cm2) (Figure 1).
(a) Subepidermal blisters with eosinophilic infiltration (H&E x200). (b) BIOCHIP demonstrated epidermal deposition on the salt-split skin substrate.
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Histopathological examination showed subepidermal blisters with eosinophilic infiltration (Figure 2(a)) and in direct IF examination linear deposition of IgG along the basement membrane zone was observed. Also, BIOCHIP mosaic-based indirect IF test demonstrated a linear deposition of IgG along the basement membrane zone on the primate monkey esophagus, epidermal deposition on the salt-split skin substrate (Figure 2(b)), and anti-BP180 and anti-BP230 positivity on transfected EU90 cells.
After treatment with 0,05% clobetasol propionate cream. Note the complete healing.
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Disease was gotten under control after 1 week and complete remission was achieved at 3rd week (Figure 3).