PMC4946863_01
Clinical picture of corneal endothelial graft rejection at baseline.. Note: Slit lamp biomicroscopy with anterior segment photography at a magnification of x16 shows intense conjunctival hyperemia and severe corneal edema with diffuse Descemet's folds.
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Slit lamp biomicroscopy with anterior segment photography at a magnification of x16 showed intense conjunctival hyperemia and severe corneal edema with diffuse Descemet's folds (Figure 1).
Confocal microscopy image at baseline.. Note: Confocal microscopy image shows increased number of dendritic cells.
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Confocal microscopy (HRT II Rostock Cornea Module; Heidelberg Engineering GmbH, Heidelberg, Germany) showed increased number of dendritic cells at the level of the corneal subbasal nerve plexus and strongly hyper reflective stromal cells likely representing keratocytes in a particular state of metabolic activation induced by proinflammatory cytokines (Figure 2).
Clinical picture of corneal endothelial graft rejection 1 month after the injection.. Note: Slit lamp biomicroscopy with anterior segment photography at a magnification of x16 shows conjunctival hyperemia recovery and improvement in corneal transparency.
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After 1 month, conjunctival hyperemia disappeared and corneal transparency improved (Figure 3).
Clinical picture of corneal endothelial graft rejection 3 months after the injection.. Note: Slit lamp biomicroscopy with anterior segment photography at a magnification of x16 shows full recovery of corneal transparency with few residual Descemet's folds not involving visual axis.
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Corneal transparency fully recovered with few residual Descemet's folds not involving the visual axis (Figure 4).
Confocal microscopy image 3 months after the injection.. Note: Confocal microscopy image shows dendritic cell number within the physiological range.
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Confocal microscopy showed dendritic cells and slightly activated keratocytes within the physiological range (Figure 5).