PMC8042541_01
A preoperative chest computed tomography scan shows about 4-cm-sized mass
with internal low attenuation and peripheral enhancement in right upper lobe
apical segment (A, arrow). A positron emission tomography-computed
tomography scan shows a well-defined lesion with intense fluorodeoxyglucose
uptake in right upper lobe (B, arrow).
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A positron emission tomography-computed tomography scan showed a well-defined mass-like lesion with intense fluorodeoxyglucose uptake in medial portion of RUL (Figure 1).
Gross photograph of the wedge resection specimen shows an ill-demarcated
yellow-tan solid mass with hemorrhage and necrosis (A). Microscopically, the
ill-defined tumor is bordered by thick inflamed tissue containing lymphoid
follicles (B, red: tumor, blue: lymphoid follicles, yellow: lung
parenchyma). The pleomorphic tumor cells show numerous neutrophils
infiltrate. Note the frequent mitotic figures (C, yellow arrows). Tumor cell
necrosis is seen, which is a feature of high-grade sarcoma (D).
Immunostaining for vimentin reveals diffuse strong cytoplasmic staining (E).
Immunohistochemistry for pancytokeratin is negative in tumor cells, while
remaining pneumocytes and bronchiolar epithelium show normal expression
(F).
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Cut section of the wedge resection specimen showed an ill-demarcated yellow-tan solid mass with hemorrhage and necrosis (Figure 2A). Microscopically, the ill-defined tumor was bordered by thick inflamed tissue containing lymphoid follicles (Figure 2B). Frequent mitotic figures were identified (Figure 2C). Several foci of tumor cell necrosis were also seen (Figure 2D). TTF-1, p63, LCA, CD34, CD30, S-100, SMA, and desmin (Figure 2E and F).