PMC5851247_01
GTG-banding revealed an unbalanced translocation t(1;16)(q25.3;q24) and balanced translocation t(3;20)(q25;q13.1) in 17/20 metaphases. All derivative chromosomes are marked and highlighted by arrow heads
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PMC5851247_01_13039_2018_370_Fig1_HTML.jpg
Fig1
GTG-banding on peripheral blood sample revealed a karyotype of 47,XY,t(1;16)(?;?),t(3;20)(?;?),+21c[17]/47,XY,+21c[3] (Fig. 1).
Karyotype and chromosomal aberrations were confirmed using molecular cytogenetic approaches. aMCB results are shown. The normal chromosomes (#) are depicted on the left side of each image and the derivative of the other chromosomes on the right side of normal chromosomes. The unstained regions when suing chromosome-specific aMCB-probesets on the derivative chromosomes are shown in gray. Abbreviations: # = chromosome; der = derivative chromosome
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PMC5851247_01_13039_2018_370_Fig2_HTML.jpg
Fig2
Further studies were performed by molecular cytogenetics (Fig. 2).