PMC5726668_01
Violaceous nodule of 2cm in diameter, with based ulceration, located on
the left forearm
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f1
A 52-year-old man was admitted to our clinic, complaining of a violaceous nodule of about 2 cm in diameter located on the left forearm (Figure 1).
A - Violaceous nodule of 0.7x 0.8cm in diameter, located on
the right forearm. B - Violaceous nodule of 1x1.5cm in
diameter with eroded surface, located on the inside portion of the left
foot.
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f2
He also presented erythematous-violaceous nodular lesions, some of which were ulcerated, located on the right arm, the back of his right hand, and his left leg and foot (Figure 2).
A - Histo-pathological evaluation revealed proliferation of
spindle-shaped cells with cytological atypia, outlining a broad network
of vascular spaces similar to slits, with some mitotic figures,
consistent with KS in the nodular phase. Hyaline globules, which are a
characteristic but not absolutely specific finding of Kaposi's sarcoma,
are also observed (Hematoxylin, original magnification, X200).
B - Immunohistochemical analysis for human herpesvirus
8 (HHV-8) in Kaposi sarcoma revealed a strong immunoreactivity of HHV-8
(Hematoxylin, original magnification, X200)
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f3
Histopathological evaluation of the forearm lesion revealed a strong proliferation of spindle-shaped cells with cytological atypia, outlining irregular slits and clefts, which is consistent with the diagnosis of KS (Figure 3).