PMC9899469_01
Axial T1- (a), T2- (b), and post-contrast axial (c) T1-weighted magnetic resonance images at the same level showing a well-demarcated extramedullary tumor (T) compressing the spinal cord from the right lateral side (asterisk). The tumor appears hypointense on T1- and hyperintense on T2-weighted sequences relative to the spinal cord, and intensely enhanced. OP: Odontoid process.
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F1
T1- and hyperintense on T2-weighted sequences, and intensely enhanced with contrast, but showed no "dural tail" (i.e., as typically seen with meningiomas) [Figures 1 and 2]. Through a C1 laminectomy, and restricted posterior foramen magnum osteotomy, she underwent gross total microsurgical resection of a well-demarcated lesion.
Post-contrast coronal (a) and midsagittal (b) T1-weighted magnetic resonance images showing an oval tumor at the C1-C2 levels. It measures 12 x 10 x 25 mm in diameter and had no dural tail. C1: Atlas; C2: Axis; T: Tumor.
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F2
T1- and hyperintense on T2-weighted sequences, and intensely enhanced with contrast, but showed no "dural tail" (i.e., as typically seen with meningiomas) [Figures 1 and 2]. Through a C1 laminectomy, and restricted posterior foramen magnum osteotomy, she underwent gross total microsurgical resection of a well-demarcated lesion.
Intraoperative photos showing (a) reflection of the dura mater exposing the tumor adjacent to the right spinal accessory nerve (XI) and vertebral artery (VA), (b) tumor adhesion (asterisk) to the right spinal accessory nerve (XI) exposed following partial tumor resection, and (c) post-total resection with the intact medulla, spinal accessory nerve (XI), tumor attachment site (asterisk), and the surrounding dura mater. Cau: Caudal; CeT: Cerebellar tonsil; Ros: Rostral.
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F3
Photomicrographs of the resected specimens showing tumor tissue comprised short spindle-shaped nuclei and intervening vasculature. The magnified view of the tumor cells (a), immunohistochemical analysis showed positive staining for epithelial membrane antigen (b), and progesterone receptor (c). The Mindbomb Homolog-1 index accounted for 10% (d). (a) Hematoxylin and eosin stain, x100; inset in (a), x400; (b-d) x100.
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F4
The Mindbomb Homolog-1 index was 10% [Figure 4].