PMC3250343_01
Generalized maculopapular skin eruption with exfoliation is observed.
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PMC3250343_01_ymj-53-231-g001.jpg
F1
Physical examination revealed a generalized erythematous maculopapular rash, which gradually became confluent and dusky (Fig. 1).
Histologic examination of the patient's skin showed subepidermal clefting and bulla formation, with necrotic keratinocytes in the middle and lower epidermis. Vacuolar degeneration was evident in the basal layer, and there was an infiltrate of lymphocytes in the upper dermis and perivascular area (hematoxylin and eosin staining, x100).
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PMC3250343_01_ymj-53-231-g002.jpg
F2
Vacuolar degeneration in the basal layer, and infiltration of lymphocytes in the upper dermis and perivascular area were also observed (Fig. 2).