PMC8844549_01
PMC8844549_02
(A) Timeline of clinical features, instrumental characteristics, and therapy approaches in the proband since the toddler started showing epilepsy. (B,C) Electroencephalogram (EEG) performed when the child was 4 years old. The trace is characterized by poorly organized brain electrical activity, slow anomalies with interictal paroxysmal abnormalities on bilateral parieto-occipital sites, and abundant epileptiform anomalies with diffuse expression.
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PMC8844549_02_fneur-12-806516-g0001.jpg
F1
At the age of 4 years (Figure 1A), the child started experiencing daily episodes of upward movements of the eyebrows associated with staring spells. Electroencephalogram (EEG) recordings while awake showed a trace characterized by poorly organized brain electrical activity and differentiated by age, slow anomalies with interictal paroxysmal abnormalities on bilateral parieto-occipital regions, and abundant epileptiform anomalies with diffuse expression, the most prolonged associated with clinical correlates (Figures 1B,C).
PMC8844549_03
PMC8844549_04