PMC9484471_01
A - Cut-section of the 2.5 x 2.0 x 1.0 cm tumor showing an encapsulated, homogenous, tan-whitish tumor, B, C and D - Photomicrographs of the tumor; B - slender background spindle cells and scattered glands (H&E x40); C - slender background spindle cells with scattered glands. A myoepithelial cell layer surrounded some glands but not others. The glands appeared to be lined by a single layer of luminal cuboidal cells(H&E x200); D - positive S100 immunohistochemical reaction in the background spindle cells. (x100).
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The tumor measured 2.5 x 2.0 x 1.0 cm (Figure 1A). Some of these glandular cells had a basal cell layer under the luminal layer, composed of smooth muscle cells (Figures 1B and 1C).
Photomomicrographs of the tumor. A - Epithelial membrane antigen (EMA) stain expressed by the epithelial cells. (EMA x200); B - The luminal cells of some of the glands expressed the low molecular weight keratin stain (LMWK x100); C - The luminal cells of some of the expressed the cytokeratin stain (CK7 x100); D - The smooth muscle actin stain was expressed by the myoepithelial cell layer that was present in some of the glands in this neurofibroma. Note: not all the glands were positive for this stain. (SMA x400).
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Some were reactive to CK7 and low molecular weight keratin (LMWK) (Figures 2B and 2C). The same glands appeared to have a second basal layer positive for smooth muscle actin (SMA) (Figure 2D).