PMC7499310_01
Graphical illustration of the course of disulfiram-induced acute hepatitis. Biological tests (AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gamma-glutamyl transferase; ALP: alkaline phosphatase) given as upper limit of normal value.
CRIHEP2020-8835647.001.jpg
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fig1
A diagnosis of acute drug-induced liver injury (DILI) due to disulfiram was made, as histological lesions were not consistent with alcoholic liver injury, and an alternative etiology was reasonable excluded.  Figure 1 illustrates the clinical course of the hepatitis and associated biological alterations.  Figure 2 illustrates histological lesions on liver biopsy.
Histological view of the liver biopsy specimen (hematoxylin-eosin stain) showing normal architecture and no fibrosis (original magnification x100, panel A). At a closer view (panel B, original magnification x200), an inflammatory infiltrate is present in the portal tract P, predominantly lymphocytic, associated with scattered eosinophils. In the liver lobule, few necrotic hepatocytes and occasional microgranulomas (arrows) are visible. Periodic acid Schiff (PAS) and Ziehl staining are negative for infections.
CRIHEP2020-8835647.002.jpg
PMC7499310_01_CRIHEP2020-8835647.002.jpg
fig2
A diagnosis of acute drug-induced liver injury (DILI) due to disulfiram was made, as histological lesions were not consistent with alcoholic liver injury, and an alternative etiology was reasonable excluded.  Figure 1 illustrates the clinical course of the hepatitis and associated biological alterations.  Figure 2 illustrates histological lesions on liver biopsy.