PMC4334324_01
Mood state of (A) Case 1 and (B) Case 2 throughout the course of the study.. Notes: The severities of depression and manic states were assessed using the MADRS as a depression rating scale and the YMRS as a mania rating scale.. Abbreviations: MADRS, Montgomery-Asberg Depression Rating Scale; YMRS, Young Mania Rating Scale.
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PMC4334324_02_ndt-11-353Fig1.jpg
f1-ndt-11-353
Figure 1B.
Correlation of plasma MHPG levels with MADRS (upper) or YMRS (lower) scores in Case 1 (A) and Case 2 (B).. Notes: There was a significant negative correlation between MHPG levels and MADRS scores (Case 1: rho=-0.542, P<0.001; Case 2: rho=-0.488, P<0.001). There was a significant positive correlation between MHPG levels and YMRS scores (Case 1: rho=0.429, P<0.001; Case 2: rho=0.465, P<0.001). Statistical analysis was performed using Spearman's correlation test.. Abbreviations: MADRS, Montgomery-Asberg Depression Rating Scale; MHPG, 3-methoxy-4-hydroxyphenylglycol; YMRS, Young Mania Rating Scale.
ndt-11-353Fig2.jpg
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f2-ndt-11-353
We also found a significant negative correlation between MADRS scores and plasma MHPG (rho=-0.465, P<0.001) and HVA (rho=-0.381, P<0.001) levels (Figure 2A).
PMC4334324_02
Mood state of (A) Case 1 and (B) Case 2 throughout the course of the study.. Notes: The severities of depression and manic states were assessed using the MADRS as a depression rating scale and the YMRS as a mania rating scale.. Abbreviations: MADRS, Montgomery-Asberg Depression Rating Scale; YMRS, Young Mania Rating Scale.
ndt-11-353Fig1.jpg
PMC4334324_02_ndt-11-353Fig1.jpg
f1-ndt-11-353
Figure 1B.
Correlation of plasma MHPG levels with MADRS (upper) or YMRS (lower) scores in Case 1 (A) and Case 2 (B).. Notes: There was a significant negative correlation between MHPG levels and MADRS scores (Case 1: rho=-0.542, P<0.001; Case 2: rho=-0.488, P<0.001). There was a significant positive correlation between MHPG levels and YMRS scores (Case 1: rho=0.429, P<0.001; Case 2: rho=0.465, P<0.001). Statistical analysis was performed using Spearman's correlation test.. Abbreviations: MADRS, Montgomery-Asberg Depression Rating Scale; MHPG, 3-methoxy-4-hydroxyphenylglycol; YMRS, Young Mania Rating Scale.
ndt-11-353Fig2.jpg
PMC4334324_02_ndt-11-353Fig2.jpg
f2-ndt-11-353
We also found a significant negative correlation between MADRS scores and plasma MHPG (rho=-0.465, P<0.001) and HVA (rho=-0.381, P<0.001) levels (Figure 2A).