PMC8995639_01
TBVC First Day - Last Daycomparison. aWell-demarcated thick hyperkeratotic verrucous plaque with a purplish base, extending from left thenar eminence to the first interdigital to the dorsum of the hand over the first interdigital fold at the time of admission. b Mild erythema and minimal residual areas at the 40th day.
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F1
The plaque had a surface area of 10 cm2 and was extending dorsally over the first interdigital fold (Fig. 1a).
aBiopsy from the plaque. Prominent thickening of stratum corneum(bold white arrow)andacanthosis (bold black arrow). Noncaseating granuloma with multinucleated Langhans cells in the center(three arrows). bA positive tuberculin skin test two days after the first visit, indicating the presence of reactive T-cells against mycobacterium.
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F2
Histological sections showed epidermal hyperplasia and dermal noncaseous granulomas (Fig. 2a). TST resulted in 12-mm induration (Fig. 2b).