PMC8264360_01
The timeline of laboratory investigations and ongoing treatments.
fimmu-12-695768-g001.jpg
PMC8264360_01_fimmu-12-695768-g001.jpg
f1
The details of the laboratory investigations and ongoing treatments are shown in  Figure 1 .
The lower limbs of the patient before and after treatment with tofacitinib. (A) The patient's lower limbs on the initial visit with 2-5 mm visible erythema with some ulceration. (B) The lower limbs of the patient after 1 month of tofacitinib administration show an improvement of skin ulcers. (C) The patient's lower limbs after 2 months of tofacitinib treatment reveal complete remission of skin ulcers. (D) The patient's lower limbs did not develop skin ulcers after 6 months of tofacitinib treatment.
fimmu-12-695768-g002.jpg
PMC8264360_01_fimmu-12-695768-g002.jpg
f2
The condition of the skin ulcers is shown in  Figure 2A . One month later, the symptoms improved steadily on this regimen ( Figure 2B ). Complete remission of skin ulcers was achieved after 2 months ( Figure 2C ). The patient stopped taking glucocorticoid treatment, and no evidence of recurrence or side effects was observed throughout the 6 months of follow-up ( Figure 2D ).