PMC3738348_01
Excision biopsy of the cervical polyp showed sheets or solid nests of epithelioid tumor cells with pleomorphic nuclei and scattered mitotic figures. (a) The tumor cells spread along the basal layer of the squamous epithelium focally (H&E, x400); (b) Some tumor cells were also positive for HMB45 (HMB45, x400)
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PMC3738348_01_10.1258_arsr.2012.120026-fig1.jpg
ARSR-12-0026F1
S-100 protein. Some of the cells were also positive for HMB-45 (Fig. 1).
After excision of the uterine cervical tumor, (a) MRI and (b) PET/CT for initial staging demonstrated two focal lesions with intense FDG uptake in the right pelvic lymph node and vagina (arrows show the lesions). The pattern was consistent with metastases. No abnormal uptake was noted elsewhere
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PMC3738348_01_10.1258_arsr.2012.120026-fig2.jpg
ARSR-12-0026F2
Initial staging with magnetic resonance imaging (MRI) showed a vaginal tumor and an enlarged lymph node in the right part of the pelvis (Fig. 2a). Whole-body PET/CT was then performed, and revealed metabolic active lesions in the areas corresponding to those seen on the MRI (Fig. 2b).
(a) Follow-up PET/CT 2 months after surgery demonstrated focal increased activity in the abdominal para-aortic lymph node (arrow); (b) Three months later, multiple metastases was observed in the brain, neck and right supraclavicular region, right breast, bilateral lungs (multiple nodules), and abdomen (nodules). Arrows indicate the lesions
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PMC3738348_01_10.1258_arsr.2012.120026-fig3.jpg
ARSR-12-0026F3
Two months after the operation, without any further treatment, PET/CT identified a recurrence of metabolic active lesions in one of the abdominal para-aortic lymph node (Fig. 3a). However, whole-body PET/CT demonstrated unsuspected multiple metastases that extensively involved the brain, right breast, both lungs, and lymph nodes of the right side of the neck, supraclavicular region, and abdominal cavity (Fig. 3b).