PMC10422895_01
EGD showing a 1- to 2-cm submucosal nodule with an overlying bloody ulcerated mucosa in (A). A fresh-appearing blood clot consistent with recent active bleeding from a mucosal ulcer is apparent in (B).. Abbreviation: EGD, esophagogastroduodenoscopy.
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Esophagogastroduodenoscopy (EGD) showed a single 15-mm cratered ulcer with an overlying blood clot in the gastric body (Figure 1).
CT scan of the abdomen showing a 3-cm heterogeneous slight rounded prominence along the inferior wall.. Abbreviation: CT, computed tomography.
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Computed tomography (CT) scan of the abdomen showed a 3-cm rounded prominence along the inferior wall of the gastric antrum adjacent to the metallic clip (Figure 2).
Photomicrographs of gastric glomus tumor. (A) The tumor extending into mucosa with mucosal ulceration and hemorrhage (hematoxylin and eosin, magnification 20x). (B) The classic features of glomus tumor with solid sheets of neoplastic cells in a background of blood vessels with varying caliber (hematoxylin and eosin, magnification 200x). (C) Immunohistochemical stains with calponin (magnification 200x). (D) Immunohistochemical stains with smooth muscle actin (magnification 200x).
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Microscopic examination revealed a tumor located within the muscularis propria with encroachment on the submucosa and mucosa with mucosal ulceration (Figure 3A). The cells were rounded to polygonal, with rounded nuclei having fine chromatin and pale cytoplasm (Figure 3B). A battery of IHC studies was performed, revealing tumor positivity for calponin and smooth muscle actin (SMA), consistent with a glomus tumor (Figure 3C and D).