PMC4094788_01
Giant OC in patient 1 from TRACP staining (400X magnification). Note the absence of bone resorption, multinucleated and detached OC from bone surface.
1472-6890-14-31-1.jpg
PMC4094788_01_1472-6890-14-31-1.jpg
F1
OC with more than 25 nuclei/cell were observed per slide and most of them were detached from the bone surface [Figure 1]. Osteoid bone and marrow cavity were normal and no woven bone was observed throughout the biopsy ruling out hyperparathyroidism or Paget's disease of bone.
PMC4094788_02
Giant OC in patient 2 from TRACP staining (200X magnification). Note that these giant OC have the same characteristics as seen in patient 1.
1472-6890-14-31-2.jpg
PMC4094788_02_1472-6890-14-31-2.jpg
F2
Again, multinucleated giant OC were observed, most of them being detached from the bone surface [Figure 2].