PMC3731173_01
Colonoscopic picture showing an ulceroproliferative growth involving the mid and lower part of rectum.
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CEA of 31.15 ng/ml. Colonoscopy showed an ulceroproliferative growth involving the lower part of the rectum (Figure 1) with lower border about 7 cm from the anal verge.
H & E staining of histopathology specimen.
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Histological examination of the biopsy specimen revealed a cluster and nests of neoplastic cells having pleomorphic nuclei invading the lamina propria with evidence of lymphovascular emboli (Figure 2).Tumor margins was negative.
HMB-45 staining.
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Immunohistochemical analysis revealed that the tumour cells were positive for HMB-45 antibody and S-100 protein (Figures 3 and 4).
S-100 staining.
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Immunohistochemical analysis revealed that the tumour cells were positive for HMB-45 antibody and S-100 protein (Figures 3 and 4).