PMC2939444_01
One dose of 800 mg of IV acyclovir was given on Day 1 and then the patient received one dose of 800 mg orally that night. On the morning of Day 2, the acute kidney injury was found and acyclovir was stopped immediately. The patient had received 800 mg of acyclovir orally five times a day for three days before hospital admission (prior to Day 1).
CRM2010-602783.001.jpg
PMC2939444_01_CRM2010-602783.001.jpg
fig1
The timing of the acute kidney injury correlated with the IV dose (see Figure 1 for graphical representation). 