PMC10214097_01
Photographs of a patient with cervical and submental lymphadenopathy.
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On physical examination, the patient was alert, had finger clubbing, and had several mobile, firm, unmated lymph nodes in the submandibular (Figure 1), cervical, supraclavicular, axillary, and inguinal regions.
Thoraco-abdominal CT scan:mediastinal, hilar, and cervical lymphadenopathy (left);
apical and basal consolidation, left lower lobe consolidation and left moderate
pleural effusion, lymph node biopsy:necrotizing inflammation (right).
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Left lower lobe consolidation, right apical and basal consolidation, a moderate pleural effusion on the left paraaortic, mesenteric, iliac, and inguinal lymph node enlargement with calcification in the center were evident (Figure 2).
Histopathology of Castleman's disease displaying thickened mantle zones with
lymphocytes arranged in layers:"onion skin appearance" H&E staining; low power
(20x) original magnification (a); intermediate power (100x) original magnification (b
and c); lymph node follicle surrounded by mantle zone composed of concentric rings of
small lymphocytes, H&E staining, 40x original magnification (d).
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Histopathology of incisional biopsy from the neck mass demonstrated a reactive lymph node highlighting prominent vascular proliferation and hyalinization of the vessel walls (Figure 3(c)), and follicle surrounded by mantle zone composed of concentric rings of small lymphocytes with onion skin like skin appearance (Figure 3(d)).
PMC10214097_02
Histopathology of Castleman's disease displaying thickened mantle zones with
lymphocytes arranged in layers:"onion skin appearance" H&E staining; low power
(20x) original magnification (a); intermediate power (100x) original magnification (b
and c); lymph node follicle surrounded by mantle zone composed of concentric rings of
small lymphocytes, H&E staining, 40x original magnification (d).
10.1177_2050313X231175720-fig3.jpg
PMC10214097_02_10.1177_2050313X231175720-fig3.jpg
fig3-2050313X231175720
Histopathology of incisional biopsy from the neck mass demonstrated a reactive lymph node highlighting prominent vascular proliferation and hyalinization of the vessel walls (Figure 3(c)), and follicle surrounded by mantle zone composed of concentric rings of small lymphocytes with onion skin like skin appearance (Figure 3(d)).