PMC10274842_01
The chronological appearance of canker sore during his chemotherapy cycles.
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He was diagnosed with ALL on April 2022 and underwent chemotherapy until the twelfth cycle with methotrexate regimen (Figure 1).
(A-F) The clinical features of the first visit showed yellowish pseudomembranous.
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Intraoral examination (Figure 2) showed 15x5 mm to 20x8 mm of irregular multiple ulcers covered by non-scraped yellowish pseudomembranous with well-defined margin, on the upper and lower labial mucosa, right and left buccal mucosa, tongue, palate, and gingiva.
(A-E) One day after the first visit: Necrotic lesions bleed easily.
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One day after the first visit, the yellowish pseudomembranous became grayish and tended to bleed (Figure 3).
(A-E) The healing process of oral lesions: (A) Initial visit, (B) 3 days of follow-up, (C) 7 days of follow-up, (D) 20 days of follow-up, (E) 3 months of follow-up.
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OM grade 3 (WHO), NUS, and oral candidiasis. One week after treatment (Figure 4), he could eat and drink normally because the oral lesions significantly improved.