PMC9092513_01
Morphologic and immunophenotypic findings of APL with cryptic PML::RARA fusion.
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Auer rods. Additionally, the nuclear features included those that are bilobed inducing a "butterfly" or "hourglass" appearance (Fig. 1a). The neoplastic promyelocytes expressed cytoplasmic myeloperoxidase and CD117 while being negative for CD34 and HLA-DR (Fig. 1b & 1c).
Cytogenetic findings of APL with cryptic PML::RARA fusion.
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Genetic studies were performed and by FISH analysis, the PML::RARA dual color dual fusion probe set (Abbott Diagnostics, Abbott Park, IL, USA) (Fig. 2a) and RARA dual color break apart probe set (Abbott) (Fig. 2b) were negative for the PML::RARA fusion as well as a RARA rearrangement. Karyotype analysis revealed a normal 46,XY[20] male karyotype (Fig. 2c).