PMC10370419_01
The abdominal CT, INR and PIVKA-II were monitored throughout the course of the disease. (A) The abdominal CT indicated early cirrhosis in November 2017, the liver volume decreased significantly in October 2021.; (B) The INR throughout the course of the disease. (C) The PIVKA-II throughout the course of the disease.
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Throughout the perioperative period, the INR was maintained between 1 and 1.5 ( Figure 1B ). Supplementary Figure 1  and  Supplementary Table 2 ) plus continuous daily temozolomide (75 mg per square metre of body-surface area per day, 7 days per week from the first day of radiotherapy for 42 days) to increase radiosensitivity. Subsequently, the patient was recruited into the follow-up phase.
PMC10370419_02
MRI examination showed a space-occupying lesion in the left frontotemporal lobe. (A) T2-weighted images; (B) T1-weighted images; (C) FLAIR showed slightly high signal and the boundary was still clear; (D) DWI showed high signal enhancement; (E) MRA showed that the compression of the bilateral anterior cerebral artery shifted to the right.
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Supplementary Figure 1  and  Supplementary Table 2 ) plus continuous daily temozolomide (75 mg per square metre of body-surface area per day, 7 days per week from the first day of radiotherapy for 42 days) to increase radiosensitivity. Subsequently, the patient was recruited into the follow-up phase.
PMC10370419_03
The abdominal CT, INR and PIVKA-II were monitored throughout the course of the disease. (A) The abdominal CT indicated early cirrhosis in November 2017, the liver volume decreased significantly in October 2021.; (B) The INR throughout the course of the disease. (C) The PIVKA-II throughout the course of the disease.
fonc-13-1209244-g001.jpg
PMC10370419_03_fonc-13-1209244-g001.jpg
f1
Throughout the perioperative period, the INR was maintained between 1 and 1.5 ( Figure 1B ). Supplementary Figure 1  and  Supplementary Table 2 ) plus continuous daily temozolomide (75 mg per square metre of body-surface area per day, 7 days per week from the first day of radiotherapy for 42 days) to increase radiosensitivity. Subsequently, the patient was recruited into the follow-up phase.
MRI examination showed a space-occupying lesion in the left frontotemporal lobe. (A) T2-weighted images; (B) T1-weighted images; (C) FLAIR showed slightly high signal and the boundary was still clear; (D) DWI showed high signal enhancement; (E) MRA showed that the compression of the bilateral anterior cerebral artery shifted to the right.
fonc-13-1209244-g002.jpg
PMC10370419_03_fonc-13-1209244-g002.jpg
f2
Supplementary Figure 1  and  Supplementary Table 2 ) plus continuous daily temozolomide (75 mg per square metre of body-surface area per day, 7 days per week from the first day of radiotherapy for 42 days) to increase radiosensitivity. Subsequently, the patient was recruited into the follow-up phase.
Histopathologic examination after HE and IHC staining of the surgical specimen. (A) The HE staining revealed rhabdoid cells features: plump cells with eccentric nuclei, open chromatin, a prominent nucleolus, and prominent eosinophilic paranuclear inclusions (yellow arrow). (B) The IHC staining of some protein.
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Histopathologic examination after HE staining of the surgical specimen revealed rhabdoid cell features: plump cells with eccentric nuclei, open chromatin, a prominent nucleolus, and prominent eosinophilic paranuclear inclusions ( Figure 3A ). However, GFAP, CK, SOX-10, HMB45, MyoD1, Syn, CGA, Myogenin, Des, PR and CD38 were negative ( Figure 3B ).
The images at the follow-up phase and the timeline for treatment regimens. (A) The head CT showed a low-density image in the left frontal blade after treatment (right) and the MRI T1-weighted image without treatment (left); (B) The chest CT scan showed a large flaky blur in posterior segment of lower lobe of right lung and considered pulmonary infection; (C) The timeline for treatment regimens.
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After 2 months of follow-up, the patient developed unexplained visual and auditory hallucinations, but the head CT showed a low-density image in the left frontal blade which was considered as the postoperative changes, no significant tumour residue or recurrence was observed ( Figure 4A ). The haematological examination revealed a significant increase in leukocyte (16.05x109/L), neutrophil (14.68x109/L), C-reactive protein (157.8 mg/L), the CT scan showed a large flaky blur in posterior segment of lower lobe of right lung and considered pulmonary infection ( Figure 4B ), and the sputum culture revealed multidrug-resistant Acinetobacter baumannii. The timeline for treatment regimens is summarised in  Figure 4C .