PMC3567407_01
PMC3567407_02
Diffuse swelling of the upper lip.
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Clinical examination found a diffuse swelling of upper lip (Figure 1) associated to lingua plicata and facial asymmetry.
Labial mucosa biopsies showed non-necrotizing giganto-epithelioid granuloma
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Labial mucosa biopsy showed non-necrotizing giganto-epithelioid granuloma confirming Miescher's cheilitis granulomatosa (Figure 2).
Intralesional betamethasone injection
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We prescribed intra-lesional betamethasone injections (7 mg / ml): 1 ml per injection (Figure 3) once a month for three months associated to a single daily dose of doxycycline 200 mg for 3 months.
Result after three months of treatment
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Gradual and permanent reduction of the upper lip volume was observed after three months of treatment (Figure 4).