PMC4910271_01
Titres of anti-FVIII and anti-FIX antibodies in our patient, measured by Bethesda assay in Ljubljana. Titres of anti-FVIII approximately 110 BU/mL and higher are accompanied by anti-FIX titres, although in a much lower titre (assuming that the cut-off for positive anti-FIX is 0.6 BU/mL). A dose-dependent effect of anti-FVIII antibodies on the anti-FIX assay is demonstrated by a linear line.
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The results of concurrent inhibitors to FVIII and to FIX, the latter in a much lower titre than inhibitors to FVIII, detected in Ljubljana laboratory by Bethesda assay, are presented in Figure 1.