PMC2834955_01
Axial and sagittal magnetic resonance images showing an enlarged left external iliac lymph node (white arrow axial, black arrow sagittal).
CDI2009-363914.001.jpg
PMC2834955_01_CDI2009-363914.001.jpg
fig1
Further evaluation included a computed tomography scan of the abdomen and pelvis, magnetic resonance imaging of the pelvis showing a normal-sized prostate with no evidence of extracapsular extension, a periprostatic lymph node measuring 1.8 cm, a left iliac lymph node measuring 2.5 x 3.8 x 3.8 cm (Figure 1), and a normal bone scan.
Three monthly vaccines were given before external beam radiation therapy (EBRT, thick line). The initial vaccine was given with an admixture of rV-PSA and rV-B7.1 with follow-up monthly boosts given with recombinant fowlpox PSA. Immunologic studies were performed prevaccination, post-3, post-4, post-5, and post-8 cycles of vaccine (designated by the arrows).
CDI2009-363914.002.jpg
PMC2834955_01_CDI2009-363914.002.jpg
fig2
This was followed by monthly boosts with a recombinant fowlpox vector expressing PSA, for a total of 8 vaccinations (Figure 2). The vaccines were given with local granulocyte-macrophage colony-stimulating factor and systemic low-dose interleukin-2 (4 MIU/M2).