PMC10294126_01
Gross mass was cystic solid. The surface was covered with coffee-like substance, and the section was gray-brown.
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F1
The surface was covered with coffee-like substances, and the section was grayish-brown (Fig. 1).
H&E staining. a At low magnification, the tumor tissue was dominated by papillary structures (HEx40). b Tumor nuclei are crowded or overlapped (HEx100). c Ground-glass nuclei, nuclear sulcus, and nuclear pseudoinclusion bodies (HEx200) were observed at high magnification. d Sand and gravel bodies are seen in the interstitium (HEx200).
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F2
Microscopically, tumor cells with papillary structure were observed in the ovarian tissue with infiltrating growth pattern, abnormal cell polarity, and overlapping and enlarged nuclei, which were ground-glass like, with nuclear sulcus, nuclear pseudoinclusion body, and gravel body, and slightly normal thyroid follicular epithelium could be seen in some areas (Fig. 2a-d).
Immunohistochemical staining for CK19 (a), galectin-3 (b), BRAF (c), TTF-1 (d), and PAX-8 (e) was positive and for TPO (f) was negative in tumor tissue as indicated in the figures.
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F3
TTF-1, CK19, galectin-3, PAX-8, and BRAF (Fig. 3a-e) but negative for TPO (Fig. 3f), CK20, P16, and WT1 and approximately 5% positive for Ki-67. The final pathological diagnosis was consistent with MSO (papillary carcinoma).