PMC7734543_01
Hematoxylin-eosin stain demonstrating histological features of low grade serous carcinoma: (a) the tumor cells, organized in nests with micropapillary pattern and characteristic retraction artifacts. Psammoma bodies are noted (x100 magnification) and (b) low grade nuclear atypia in tumor cells seen on higher magnification (x400 magnification).
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The surrounding stroma had a prominent desmoplastic response (Figure 1).
Selected immunohistochemical stains demonstrated in tumor cells. Positive staining for CK7, PAX8, BerEP4, and negative staining for CK20 and WT-1. Wild-type staining for p53 (x100 magnification).
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The tumor cells were negative for CK20, CK 5/6, WT1, calretinin, TTF-1, thyroglobulin, D2-40, mCEA, ER, PR, CDX2 (Figure 2).