PMC5474248_01
Peripheral blood smear with pancytopenia and teardrop red blood cells (Wright 400x).
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fig1
Peripheral blood smear noted teardrop red blood cells and circulating nucleated red cells (Figure 1).
Epidermal atrophy with prominent basement membrane (H&E 100x). Dermal edema with blue mucin and mild perivascular mononuclear infiltrate (mainly lymphocytes).
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fig2
Pathology at the site of violaceous rash on forehead was consistent with dermatomyositis (Figures 2-4).
Vacuolar change due to basal cell degeneration (H&E 200x). Civatte bodies at the papillary dermis. Prominent perivascular lymphocytes at left lower corner.
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fig3
Pathology at the site of violaceous rash on forehead was consistent with dermatomyositis (Figures 2-4).
Melanin incontinence into dermis (yellow arrow) (H&E 400x).
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fig4
Pathology at the site of violaceous rash on forehead was consistent with dermatomyositis (Figures 2-4).
The bone is normocellular with megakaryocytic hyperplasia and moderate fibrosis (bone marrow, left posterior iliac crest, clot section, and trephine core biopsies, 100x).
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fig5
Pathologist review reported normocellular marrow with megakaryocyte hyperplasia, mild decrease in erythroid precursors, and moderate fibrosis (Figures 5-6).
Marrow reticulin fibers moderately increased with storage iron present (bone marrow biopsy, left posterior iliac crest, and reticulin stain, 400x).
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fig6
Pathologist review reported normocellular marrow with megakaryocyte hyperplasia, mild decrease in erythroid precursors, and moderate fibrosis (Figures 5-6).