PMC4429839_01
A. Low power view of the skin nodule exhibiting skin with underlying lakes of mucin compartmentalised by delicate fibrous septae and floating nests and ducts of tumour cells B&C. Higher power showing variability in cellularity and proliferation of neoplastic cells ranging from less cellular nests/ducts to more cellular areas with cribriforming.
gr1.jpg
PMC4429839_01_gr1.jpg
fig0005
The tumour showed no connection to the overlying skin or adnexal structures (See Fig. 1).
Immunohistochemistry shows tumour cells to be strongly positive for CK7, oestrogen receptors (ER), and progesterone receptors (PR) and negative for CK 20.
gr2.jpg
PMC4429839_01_gr2.jpg
fig0010
The cells were negative for cytokeratin 20 (CK20) and Her-2-neu (See Fig. 2).