PMC5003554_01
Case 18: SD-OCT images and FAF images of stage 3 MH.. Notes: (A) Preoperative OCT imaging showed stage 3 MH with fluid cuff. (B and C) Optos FAF images (ResMax mode) showed increased autofluorescence signal corresponding to the MH (dotted circle). (D) On day 1, MH was probably closed based on OCT in the SF6 gas-filled eye. (E and F) FAF Optos images on the first day after surgery showed no autofluorescence in the macula in SF6 gas-filled eye. (G) OCT image on day 7 after the vitrectomy. (H and I) After the gas was decreased to approximately 40% of the vitreous (arrows), autofluorescence in the macula was confirmed by Optos on day 7. (J-L) Quantitative analysis indicates high FAF intensity corresponding to MH (J) and decreased FAF intensity 1 day (K) and 7 days (L) after surgery (arrows). Dotted square in B, E, and H corresponds to C, F, and I at high magnification, respectively. Dotted line in F and I indicates the line that was used for quantitative analysis of the FAF intensity.. Abbreviations: FAF, fundus autofluorescence; MH, macular hole; OCT, optical coherence tomography; SD-OCT, spectral domain-OCT; SF6, sulfur hexafluoride.
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f1-opth-10-1623
A 65-year-old woman had a stage 3, 316 mum MH in the right eye (Figure 1A). Optos revealed an autofluorescence signal corresponding to the MH (Figure 1B and C). On day 1 after vitrectomy, OCT was not identifiable clearly (Figure 1D). Optos in the SF6 gas-filled eye (Figure 1E and F). On postoperative day 7 after the gas disappeared, OCT confirmed that the hole was closed with small subfoveal space (Figure 1G). Optos also could not detect any significant foveal autofluorescence signal (Figure 1H and I). Quantitative analysis showed a gradual decrease in FAF intensity during MH closure after the surgery (Figure 1J-L, Table 4).
PMC5003554_02
Case 1: SD-OCT images and FAF images of stage 4 MH.. Notes: (A) Preoperative OCT imaging showed stage 4 MH. (B and C) Optos FAF images showed high autofluorescence signal corresponding to the MH (arrow). (D and G) OCT showed bridge formation (foveal detachment) in SF6 gas-filled eye on day 1 as well as in the gas-absent eye on day 7, respectively. (E, F, H, and I) FAF images on the first and seventh day after surgery showed slight autofluorescence in the macula. Arrows indicate autofluorescence signal in the macula. (J-L) Quantitative analysis indicates high FAF intensity corresponding to the MH (J) and decreased FAF intensity 1 day (K) and 7 days (L) after surgery (arrows). Dotted square in B, E, and H corresponds to C, F, and I at high magnification, respectively. Dotted line in C, F, and I indicates the line that was used for the quantitative analysis of FAF intensity.. Abbreviations: FAF, fundus autofluorescence; MH, macular hole; OCT, optical coherence tomography; SD-OCT, spectral domain-OCT; SF6, sulfur hexafluoride.
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f2-opth-10-1623
A 64-year-old woman had a stage 4 MH in the left eye (Figure 2A). Study of FAF images obtained with Optos showed an increased autofluorescence signal corresponding to the MH (Figure 2B and C). On postoperative day 1, OCT showed bridge formation (foveal detachment) (Figure 2D). Study of FAF images obtained with Optos showed reduced but persistent autofluorescence in the macula in the SF6 gas-filled eye (Figure 2E and F). After reabsorption of the gas, the OCT examination confirmed foveal detachment (Figure 2G). FAF imaging by Optos showed a ring of hypoautofluorescence surrounding the central area of relative hyperautofluorescence (Figure 2H and I).