PMC4247802_01
(A) On gross examination, the brunt of the cerebellar atrophy involves the upper vermis and adjacent parts of the hemispheres. (B) Micrographs show subtotal loss of Purkinje cell loss with severe Bergmann gliosis (Luxol fast blue H&E [LH&E], 200x), (C) empty baskets (Bielshowsky, 400x), (D) moderate neuronal loss and reactive gliosis involving the dentate nucleus (LH&E, 400x), (E) scattered atrophic neurons with mild gliosis involving the red nucleus (LH&E, 400x), (F) severe neuronal loss involving the inferior olivary nucleus with myelin loss of the amiculum or central tegmental tract (upper-left corner) and of the hilus (lower-right corner) (LH&E, 200x).
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F1
On postmortem examination, the cerebellum was atrophic (figure 1A), more prominent in the vermis than in the hemispheres. There was subtotal loss of Purkinje cells and severe Bergmann gliosis (figure 1B), and numerous empty baskets (figure 1C) and severe myelin loss of the foliae and album cerebelli. There was moderate neuronal loss in the dentate nucleus with reactive gliosis (figure 1D). The red nucleus had scattered atrophic neurons and mild gliosis (figure 1E). There was severe neuronal loss in the inferior olivary nucleus (ION) (figure 1F) with loss of myelin in the amiculum or central tegmental tract, hilus and olivocerebellar fibres.