PMC9083221_01
RT-PCR cycle threshold values for SARS-CoV-2 in respiratory samples of the mother and both neonates in relation to maternal clinical course. The dotted horizontal line indicates the detection threshold set at 34, distinguishing between positive and negative (marked as yellow) RT-PCR results. Negative RT-PCR results are displayed as ct values of 36. Day of cesarean section is defined as day 0, represented with a gray, vertical, dotted line. Positive RT-CPR results of the mother's respiratory samples are highlighted in red in the arrow illustrating the maternal clinical course.
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F1
Two days later, however, she developed a mild cough and SARS-CoV-2 infection was confirmed by RT-PCR of her nasopharyngeal swab (Figure 1). SARS-CoV-2 infection was diagnosed in both neonates by RT-PCR in their nasopharyngeal swabs with low cycle threshold (ct) values and was confirmed by multiple consecutive RT-PCR tests (Figure 1). SARS-CoV-2 sequencing revealed the Delta variant in both neonates, as well as in the respiratory sample of the supposed index person of the mother (B1.617.2). High-flow oxygen therapy was gradually reduced and after 4 days on the ICU she was transferred back to a regional hospital (Figure 1).
Absolute neutrophil (A), lymphocyte (B) and thrombocyte (C) counts [/nl] of neonate A (red) and B (blue). The purple dotted vertical line indicates the first positive RT-PCR result of the neonates' nasopharyngeal swab. The gray dotted horizontal line indicates lowest range of the reference interval.
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F2
Absolute neutrophil levels, however, were persistently low over months (Figure 2).