PMC2639602_01
(H&E). Langerhans cell histiocytosis of the bone. Collections of eosinophils and mononuclear Langerhans cells. x10.
1752-1947-3-35-1.jpg
PMC2639602_01_1752-1947-3-35-1.jpg
F1
Langerhans cells (Figure 1). Langerhans cells showed somewhat glassy pink cytoplasms, indistinct cell borders and longitudinal coffee-bean grooves in their nuclei with undulating or indented nuclear membranes.
Langerhans cell histiocytosis of the bone. Immunohistochemical positive reaction with S100 in bone lesion x10.
1752-1947-3-35-2.jpg
PMC2639602_01_1752-1947-3-35-2.jpg
F2
The immunohistochemical staining showed positive reactivity for S100 and CD1a and negative reactivity for CD15 and CD30 in large cells with folded nuclei (Figure 2).