PMC8087171_01
Essential elements for pemphigus and COVID-19 diagnosis. (A) Intercellular deposition of IgG (arrow heads) by direct immunofluorescence microscopy; (B) Chest radiograph of pemphigus patient with COVID-19 showing interstitial pneumonia with bilateral airspace opacities.
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f1
She was affected by pemphigus foliaceous, as assessed by clinical examination and direct immunofluorescence microscopy ( Figure 1A ), from January 2019 and received a cycle of RTX (500 mg x 4 weekly infusions) in May 2019 reaching complete remission off-therapy in November 2019 ( Figure 2 ). The chest radiograph showed interstitial pneumonia with bilateral airspace opacities ( Figure 1B ).
Timeline with relevant data from the episode of care.
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f2
She was affected by pemphigus foliaceous, as assessed by clinical examination and direct immunofluorescence microscopy ( Figure 1A ), from January 2019 and received a cycle of RTX (500 mg x 4 weekly infusions) in May 2019 reaching complete remission off-therapy in November 2019 ( Figure 2 ). SARS-CoV-2 ( Figure 2 ). She was admitted to the Geriatric-COVID-19 Unit of the referral hospital in Bolzano-Bozen. After two positive swabs, 18 days from admission a further nasopharyngeal swab was negative for SARS-CoV-2, so the patient was discharged continuing oral methylprednisolone 8 mg qd ( Figure 2 ).