PMC3245604_01
Gross findings of the uterus. A huge ulceroinfiltrative necrotic mass measuring 40 x 40 mm is located on the posterior wall and a diffuse dark reddish hemorrhagic nodule (arrows) is located in the serosa of the uterine fundus and internal cervical os.
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F1
The tumor shows endometrioid adenocarcinoma (A) with squamous differentiation (B). The same components in p53 stained sections (C, D).
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F2
Approximately half of the tumor showed an endometrioid adenocarcinoma with squamous differentiation (Figure 2A, 2B). Positive immunohistochemical nuclear staining of p53 was detected in three distinct histological types (Figure 2C, 2D, 3C and 4B).
The choriocarcinoma component is composed of syncytiotrophoblast-like cells and cytotrophoblast-like cells (A). Immunohistochemical staining for hCG-beta subunit of the choriocarcinoma component shows a positive reaction in syncytiotrophoblast-like cells (B). The same components in p53-stained sections (C).
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F3
The hemorrhagic nodule showed a choriocarcinoma component with a two-cell pattern that had syncytiotrophoblast-like and cytotrophoblast-like elements (Figure 3A). Immunohistochemical staining for hCG-beta subunit was positive, especially in the syncytiotrophoblast-like element (Figure 3B). Positive immunohistochemical nuclear staining of p53 was detected in three distinct histological types (Figure 2C, 2D, 3C and 4B).
Peritoneal dissemination of the sigmoid colon shows papillary serous adenocarcinoma (A) and p53 positivity (B).
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F4
The biopsy specimen derived from peritoneal dissemination of the sigmoid colon showed a serous papillary adenocarcinoma (Figure 4A). Positive immunohistochemical nuclear staining of p53 was detected in three distinct histological types (Figure 2C, 2D, 3C and 4B).
The recurring tumor shows poorly differentiated adenocarcinoma with numerous mitoses (A). Immunohistochemical staining for hCG-beta subunit and p53 shows a positive reaction in part of the mononuclear cells (B, C).
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F5
A surgical biopsy showed poorly differentiated carcinoma with mononuclear cells (Figure 5A) without any primary pathological features, although immunohistochemical staining for hCG-beta subunitand p53 was positive in part of the mononuclear cells, suggested cytotrophoblastic differentiation (Figure 5B and 5C).