PMC5943890_01
MRI findings. MRI shows an irregular, cystic:solid mass approximately 4.5 x 4.7 x 6.4 cm in size, with surrounding edema in the right frontal lobe. The solid part and cystic wall of the lesion exhibit isointensity on (A) T1WI and (B) T2WI. Several spots of hypointensity on T1 and T2WI, as well as patches of slight hyperintensity on T1WI are also shown in the solid part of the tumor. (C) Contrast enhancement is clearly observed in the solid part and cystic wall. T1WI, T1-weighted image; T2WI: T2-weighted image. MRI = magnetic resonance imaging, T1WI = T1-weighted imaging, T2WI = T2-weighted imaging.
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F1
T2WI, and a few patches of slight hyperintensity on T1WI and hypointensity on T2WI were also found. The cystic part of the lesion was observed with uniform hypointensity on T1WI and hyperintensity on T2WI. The solid part and cystic wall were clearly enhanced after gadolinium administration (Fig. 1A-C).
(A, B) Histopathological and (C-E) immunohistochemical features. (A) H&E stained section shows sheets of relatively isomorphic tumor cells with round nuclei, clear cytoplasm, and large lipid vacuoles among neoplastic cells (original magnification x200). (B) Tumor cells have round nuclei with indistinct nucleoli and fine chromatin (original magnification x400). (C) Tumor cells are diffusely immunoreactive for synaptophysin. (D) Tumor cells show strong labeling with MAP-2. (E) NeuN is focally positive in tumor cells (original magnification x200). H&E = hematoxylin and eosin, MAP-2 = microtubule-associated protein 2, NeuN = neuronal nuclei antigen.
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F2
The tumor cells showed round nuclei, clear cytoplasm, and close arrangement (Fig. 2A and B). In immunohistochemical analysis, synaptophysin (Fig. 2C) and MAP-2 (Fig. 2D) immunopositivity were detected, and NeuN (Fig. 2E) and GFAP were also focally observed.