PMC10328559_01
Case data of patient 1. (A) Gastroscope and imaging examination.Changes of tumor or lymph node in gastroscopy and enhanced CT before treatment, after 2 and 4 cycles treatment. (B) Pathology examination (1): biopsy pathology before treatment (adenocarcinoma);(2): pathology after surgical resection (no tumor cells found) (C) Treatment process under DSA (1): angiography showed that the feeding artery of the tumor was gastroduodenal artery; (2): microcatheter tip placement location (in gastroduodenal artery).
fonc-13-1214599-g001.jpg
PMC10328559_02_fonc-13-1214599-g001.jpg
f1
Biopsy pathology diagnosis was showed adenocarcinoma [ Figure 3B  (1)].
Changes of weight and blood cells in patient 1 and 2 during treatment. (A) Changes of weight during treatment. (B) Changes of hemoglobin during treatment. (C) Changes of PLT, WBC& neutrophils during treatment.
fonc-13-1214599-g002.jpg
PMC10328559_02_fonc-13-1214599-g002.jpg
f2
Throughout the treatment, the patient had grade I myelosuppression, and resolved spontaneously without special treatment ( Figure 2 ). Changes in weight and blood cells during treatment were shown in ( Figures 2 .
PMC10328559_02
Case data of patient 1. (A) Gastroscope and imaging examination.Changes of tumor or lymph node in gastroscopy and enhanced CT before treatment, after 2 and 4 cycles treatment. (B) Pathology examination (1): biopsy pathology before treatment (adenocarcinoma);(2): pathology after surgical resection (no tumor cells found) (C) Treatment process under DSA (1): angiography showed that the feeding artery of the tumor was gastroduodenal artery; (2): microcatheter tip placement location (in gastroduodenal artery).
fonc-13-1214599-g001.jpg
PMC10328559_02_fonc-13-1214599-g001.jpg
f1
Biopsy pathology diagnosis was showed adenocarcinoma [ Figure 3B  (1)].
Changes of weight and blood cells in patient 1 and 2 during treatment. (A) Changes of weight during treatment. (B) Changes of hemoglobin during treatment. (C) Changes of PLT, WBC& neutrophils during treatment.
fonc-13-1214599-g002.jpg
PMC10328559_02_fonc-13-1214599-g002.jpg
f2
Throughout the treatment, the patient had grade I myelosuppression, and resolved spontaneously without special treatment ( Figure 2 ). Changes in weight and blood cells during treatment were shown in ( Figures 2 .
Case data of patient 2. (A) Gastroscope and imaging examination. Changes of tumor or lymph node in gastroscopy and enhanced CT before treatment, after 2 and 4 cycles treatment. (B) Pathology examination (1): biopsy pathology before treatment (adenocarcinoma); (2): pathology after surgical resection (no tumor cells found). (C) Treatment process under DSA (1): angiography showed that the feeding artery of the tumor was left gastric artery; (2): microcatheter tip placement location (in left gastric artery) Note: Figure 3A - green arrows. After 2 cycles of treatment, gastroscope also showed multiple small ulcers in the gastric body of patient 2, which was considered to be gastric mucosal reaction caused by high-concentration chemotherapy drugs in arterial infusion chemotherapy. After treatment with proton pump inhibitors, the patient's multiple ulcers improved and healed.
fonc-13-1214599-g003.jpg
PMC10328559_02_fonc-13-1214599-g003.jpg
f3
Gastroscopy showed ulcerative neoplasia about 3cmx4cm in size on the posterior wall of lesser curvature of stomach, hyperemia and erosion, brittle and easy to bleed ( Figure 3A ). Biopsy pathology diagnosis was showed adenocarcinoma [ Figure 3B  (1)]. Abdominal enhanced CT showed the presence of metastasis in regional lymph node but no distant metastasis ( Figure 3A ), and the clinical stage was cT3N2M0, stage III. DSA showed that the left gastric artery was the main feeding artery for the tumor [ Figure 3C  ]. Under DSA guidance, a microcatheter was placed in the left gastric artery [ Figure 3C  ], and chemotherapy drugs were pumped through the indwelling arterial catheter. Enhanced CT and gastroscopy of the abdomen showed a significant reduction in tumor volume and irregular superficial ulceration ( Figure 3A ). After treatment with proton pump inhibitors, the patient's multiple ulcers improved and healed ( Figure 3A , green arrows). The imaging findings showed further tumor shrinkage ( Figure 3A ), and the efficacy evaluation was PR. Postoperative pathology showed no tumor cells in gastric ulcer and lymph nodes [( Figure 3B  ], TRG grade was 0.