PMC2631530_01
CT slice showing new lesion in oropharynx.
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F1
As a result of ongoing odynophagia, a repeat CT scan was requested at a further 2 month interval (nine months after the onset of symptoms) which revealed a new lesion in the oropharynx [fig 1] and significant adenopathy within the neck (cervical and supraclavicular lymph nodes), more marked on the left than right.
Biopsy of oropharnyx confirming submucosal metastatic invasive ductal carcinoma.
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F2
Subsequent examination under anaesthetic and biopsy of the area confirmed submucosal metastatic invasive ductal carcinoma with some lobular differentiation [fig 2].
E-cadherin stain on oropharyngeal biopsy.
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F3
E-Cadherin staining showed strong expression within the majority of the tumour cells [fig 3].