PMC8552972_01
A - Low power photomicrograph demonstrating involvement of gall bladder mucosa (H&E 40X); B-D - High power photomicrographs showing cytologic details; cells with spindly nuclei and indistinct cytoplasmic margins (H&E 100X, 200X and 400X).
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Histologic evaluation showed diffuse bulbous expansion of the mucosa with cells with spindly nuclei and indistinct cytoplasmic margins (Figures 1A-D).The proliferation was diffuse, unencapsulated, and diffusely replaced the lamina propria.
Immunohistochemical stains showing the lesional cells to be A - positive for S-100p; B - negative for EMA, C - CD34, and D - CD68.
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Immunohistochemical stains showed that the lesional cells were positive for S100p while were negative for EMA, CD34, and CD68 (Figures 2A-D).