PMC6336651_01
Vulvar angiomyxoma. (A) The mass before the local excision. (B) 12 months after aggressive angiomyxoma surgery.
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F1
The pedicle extended from the middle left vulva to perineal body with several ulcers on the surface (Fig. 1A). No evidence of recurrence or distant metastasis was observed during the 12-month follow-up period (Fig. 1B).
The histologic pathologies of aggressive angiomyxoma. (A) Small, prominent, and dilated blood vessels with different diameters and thickness walls existed in the tumor (x100). (B) The tumor is constituted of small spindle and stellate fibroblasts with collagen fibers. The tumor cells are eosinophilic, slightly deep staining, and adipose tissue can be seen (x200).
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F2
The tumor was composed of small spindle and stellate fibroblasts and mitotic cells were absent (Fig. 2).
The immunohistochemistry of aggressive angiomyxoma. The cells are positive for estrogen receptor, CD34, Ki67, and smooth muscle actin (x200).
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F3
The cell proliferation marker Ki67 accounted for about 2% of total cells (Fig. 3).