PMC8597387_01
Endoscopic appearance of the colonic lesion: sessile polyp with central depression
RJME-62-1-313-fig1.jpg
PMC8597387_01_RJME-62-1-313-fig1.jpg
F1
The other was a sessile, non-ulcerated polyp, centrally depressed, with a smooth surface, measuring 20 mm, located at 50 cm from the anal verge (Figure 1).
Low-grade dysplasia tubular adenoma of the colon with oxyntic GH: (A) Low power image - the arrow points to a focus of GH; (B) Medium power image showing dysplastic tubules and oxyntic cells. HE staining: (A and B) x200. GH: Gastric heterotopia; HE: Hematoxylin-Eosin
RJME-62-1-313-fig2.jpg
PMC8597387_01_RJME-62-1-313-fig2.jpg
F2
Histological examination of this polyp identified a tubular adenoma with focal low-grade dysplasia and ectopic gastric oxyntic epithelium (Figure 2A). This epithelium showed all the elements present in normal orthotopic oxyntic mucosa sharply delimited from the surrounded tubules of the adenoma (Figure 2B).
Oxyntic GH: (A) Parietal and chief cells are present between the tubules of the adenoma; (B) Oxyntic cells show positive cytoplasmic reactivity for MUC6. HE staining: (A) x400. Anti-MUC6 antibody immunomarking: (B) x400. GH: Gastric heterotopia; HE: Hematoxylin-Eosin; MUC6: Mucin 6
RJME-62-1-313-fig3.jpg
PMC8597387_01_RJME-62-1-313-fig3.jpg
F3
Both types of cells showed small, eccentric, round, uniform nuclei (Figure 3A). The MUC6 immunoexpression was cytoplasmic (Figure 3B).