PMC9720239_01
A, Papillon-Lefevre syndrome PLS (hands palmar surface at base line). B, Papillon-Lefevre syndrome (hands dorsal surface at base line).
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fig1
Papillon-Lefevre syndrome (hands palmar surface at 2 months post treatment).
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fig2
On examination after treatment with dimethyl fumarate, both palmar surfaces demonstrated significant improvement, with very faint erythema and scales on both thenar and hypothenar eminences (Fig 2).
A, Papillon-Lefevre syndrome (hands palmar surface 5 months post treatment). B, Papillon-Lefevre syndrome (hands dorsal surface 5 months post treatment).
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fig3
A, Papillon-Lefevre syndrome (left plantar surface at baseline). B, Papillon-Lefevre syndrome (left plantar surface 5 months post treatment).
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fig4