PMC5771930_01
(A) Homogeneously increased 18F-FDG-uptake in the bone marrow. (B) Homogeneously increased 18F-FDG-uptake in the spleen. PET/CT scan was performed using a dedicated 64-slice body PET/CT scanner (Biograph mCT). A 6-h fasting period is required before the intravenous injection of the activity of 356 MBq 18F-FDG can be applied. Imaging was started with a low-dose CT of the whole body 1 h after the injection. PET scans were performed in caudocranial direction with 2 min per bed position.
CCR3-6-78-g001.jpg
PMC5771930_01_CCR3-6-78-g001.jpg
ccr31259-fig-0001
(A and B) Pathological examination of the bone marrow including hematoxylin and eosin (H&E) staining revealed macrophages with intracytoplasmic microorganisms.
CCR3-6-78-g002.jpg
PMC5771930_01_CCR3-6-78-g002.jpg
ccr31259-fig-0002
B) showed tracer enhancement in the central and peripheral bone marrow. Bone marrow biopsy revealed microorganisms within macrophages (Fig. 2).