PMC3589216_01
Notably increased corneal thickness accompanied by severe subepithelial and anterior stromal fibrosis (F), foci of neovascularization with intra-stromal inflammation and severe loss of corneal endothelial cells (hematoxylin & eosin staining, x40).
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Light microscopy of H&E stained sections revealed corneal thickness to about 2 mm (Fig. 1), irregular and somehow thinned epithelium with basal and subepithelial bullous changes (Fig. 2-A). The Descemet membrane had apparently normal thickness, however endothelial cell count was severely reduced (Fig. 1).
(A) Bullous changes in the basal epithelial cells (hematoxylin & eosin staining, x400); (B) Neovascularization foci with chronic granulomatous inflammation and intra-stromal cholesterol clefts (hematoxylin & eosin staining, x200).
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Extensive foci of stromal neovascularization accompanied by chronic granulomatous inflammation (Fig. 2-B) with giant multinuclear cells (Fig. 3-A) surrounding intrastromal cholesterol clefts (Fig. 3-B) were seen.
(A) Multinuclear giant cells (G) in lipogranulomatous reaction of the stroma and foci of neovascularization (hematoxylin & eosin staining, x400); (B) Intra-stromal cholesterol clefts (C) and lipogranulomatous reactions (hematoxylin & eosin staining, x200).
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Extensive foci of stromal neovascularization accompanied by chronic granulomatous inflammation (Fig. 2-B) with giant multinuclear cells (Fig. 3-A) surrounding intrastromal cholesterol clefts (Fig. 3-B) were seen.