PMC7322166_01
(A) Cystoscopy image showing a neoplasm grown surrounding the distal urethra. (B) An ideograph displaying the appearance and invasion range of the tumor in the urethra.
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Cystoscopy revealed a tumor growing around the urethra about 1 cm from the external urethral meatus and biopsy was taken (Figure 1A). The tumor appeared to invade the corpus spongiosum (Figure 1B).
Microphotograph of the mass revealed high-grade urothelium carcinoma (hematoxylin-eosin, x 100 magnification (A) and x 200 magnification (B)).
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Histopathologic examination reported urothelial hyperplasia and squamous cell differentiation arranged in papilla (Figure 2).
Immunohistochemistry of the tumor revealing: P16(-) (A), P53(partly+) (B), CK7(+) (C), CK8(+) (D), CK20(-) (E), UroplakinII(-) (F), P63(+) (G), Ki-67(+,50%) (H).
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Immunohistochemical analysis was carried out and reported as following: P16(-), P53(partly+), CK7(+), CK8(+), CK20(-), UroplakinII(-), P63(+), Ki-67(+,50%), confirming the diagnosis of high-grade papillary urothelium carcinoma (Figure 3).