PMC6452554_01
Skin lesions. (a) Skin rash with annular erythematous lesions on the face. (b) Annular, erythematous, scaly, atrophic patches on the trunk and back (arrows).
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fig1
She had congenital erythematous and scar lesions on the face, back, and upper and lower extremities (Figure 1).
Histological findings from placentas obtained from the control pregnancy (28-year-old mother at 35 weeks of gestation, (a, b)), systemic lupus erythematous (SLE) pregnancy (40-year-old mother at 30 weeks of gestation, (c, d)), and neonatal lupus syndrome pregnancy (31-year-old mother at 35 weeks of gestation, (e, f)). (a, c, e) Representative images of tissue sections stained with hematoxylin and eosin (HE). (b, d, f) Representative anti-C4d immunostaining images (arrows). Scale bar = 50 mum.
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fig2
Histological examination revealed collapsed capillaries in the terminal villi (Figure 2(e)). Immunohistostaining of a normal placenta (Figure 2(b)), placenta with maternal SLE (Figure 2(d)), and the placenta involved in this case (Figure 2(f)) was performed using C4d (ABGENT, San Diego, CA, USA). C4d deposits were present at the syncytiotrophoblasts, but not in the lumen of the vessels (Figure 2(b)). C4d deposits were strongly observed at the syncytiotrophoblasts in SLE cases (Figure 2(d)). C4d deposition in the lumen of the capillaries of the terminal villi (Figure 2(f)).