PMC9421359_01
Timeline of the patient's clinical manifestations and treatment. (A) Timeline of the patient's tests and treatment. (B) Timeline of the patient's body temperature.
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F1
After 8-days of administration and a poor response to antibiotic therapy, blood was collected for mNGS (Figure 1).
The coverage depth forTalaromyces marneffei.
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F2
TM infection on the 9th day of hospitalization, and with the quick mNGS results (Figure 2), intravenous amphotericin B (0.1-0.5 mg/kg/day, with gradual increase every 2 days) and oral itraconazole (4 mg/kg/dose bid) were administered. The patient's condition improved dramatically.
Sequencing maps of CD40LG gene variants in the infant and his parents.
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F3
The father had the wild-type sequence (Figure 3).