PMC5909024_01
Histology of consecutive trephine bone marrow biopsies (BMB). Pre-treatment BMB showed marked reticulin and collagenic interstitial fibrosis (MF-3) (A Haematoxylin and Eosin stain x100; B Gomori reticulin stain x100). During treatment BMB showed reduced collagenic interstitial fribrosis (MF-2) (C Haematoxylin and Eosin stain x100; D Gomori reticulin stain x100). Post treatment BMB showed regression of bone marrow fibrosis (MF-0) (E Haematoxylin and Eosin stain x100; F Gomori reticulin stain x100).
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A marked interstitial reticulin and collagen fibrosis (MF-3) was also evident (Fig. 1A,B). After 6 months a bone marrow biopsy was repeated showing "hypercellular marrow (70%) due to myeloid and megakaryocyte proliferation with seldom hyperchromatic nuclei, decreased, reticulin fibrosis with focal formation of collagen bundles (MF-2)" (Fig. 1C, D). After one year of treatment, a follow-up bone marrow biopsy was further performed demonstrating a 30% cellular marrow and complete remission of bone marrow fibrosis (MF-0) (Fig. 1E, F).