PMC7446499_01
Shrinkage of the patient's (A-C) cardiophrenic, (D-F) para-aortic, and (G-I) left lateral iliac lymph nodes after 3 months of olaparib treatment. Computed tomographic imaging of the abdomen and pelvis (A, D, G) before treatment, (B, E, H) after second-line chemotherapy, and (C, F, I) after olaparib treatment.
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Computed tomography (CT) revealed multiple swollen cardiophrenic, para-aortic, and left lateral iliac lymph nodes and omental cake (Fig 1). After first-line chemotherapy, CT indicated stable disease based on RECIST 1.0 criteria, with only improvements in the cardiophrenic swollen lymph node (Fig 1). After six cycles, CT revealed essentially stable disease without improvement in the para-aortic or left lateral iliac swollen lymph nodes (Fig 1). Appendix Figures A1 and A2. All detected variants, including variants of unknown significance are presented in Appendix Table A1. A CT scan 3 months after olaparib initiation showed the disappearance of all residual swollen lymph nodes in the pelvis (Fig 1).
(A) Copy-number alteration and (B) variant allele frequency (VAF) indicating homologous recombination deficiency pattern. The horizontal axis corresponds to each examined gene, and the vertical axis corresponds to the (A) copy number or (B) VAF.
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Appendix Figures A1 and A2. All detected variants, including variants of unknown significance are presented in Appendix Table A1. Copy-number variation box and variant allele frequency plots (Fig 2) indicated a high LOH frequency and scattered allelic imbalance, which are often detected in homologous recombination-deficient tumors.