PMC5298546_01
(a) Lateral lumbar spine radiograph in a 9-year-old girl showed defective ossification of the anterior portions of the upper and lower end-plates, and L-3 specifically showed marked anterior ossification defect (anteriorly pointing) associated with reduction of the height of the upper lumbar bodies. (b) Sagittal MRI of the lumbar spine of the same girl at the age of 13 years showed progressive platyspondyly, Schmorl's node (arrow), anterior end-plates defective ossifications, and signs of osteochondritis (severe irregularities at the end plates of vertebral bodies with intervertebral and retromarginal herniations).
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Lateral lumbar spine radiograph in a 9-year-old girl showed defective ossification of the anterior portions of the upper and lower end plates, and L-3 specifically showed marked anterior ossification defect (anteriorly pointing) associated with reduction of the height of the upper lumbar bodies (Figure 1a). Sagittal MRI of the lumbar spine of the same girl at the age of 13 years showed progressive platyspondyly, Schmorl's node, anterior end-plates defective ossifications, and signs of osteochondritis (severe irregularities at the end plates of vertebral bodies with intervertebral and retromarginal herniations; Figure 1b).
Magnetic resonance imaging (1.5 T) in a 13-year-old girl with PPRC showed intraarticular pathology strongly compatible with the radiographic features of osteoarthritis. Note the laterally prominent femoral head margins create bilateral femoral head asphericity. The capital femoral epiphyses are flattened, irregular associated with metaphyseal fragmentation and irregularity. The superior portions of the acetabular labra were sclerosed with partial detachment.
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The superior portions of the acetabular labra were sclerosed with partial detachment (Figure 2).
Lateral spine radiograph in a 10-year-old child with Klinefelter syndrome showed exaggerated lumbar lordosis, mild platyspondyly of T11-12, anterior end-plate irregularity of T12, scalloping of the posterior end plate of L3.
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Two boys gave the clinical phenotype of Klinefelter syndrome, and on the basis of skeletal survey, the lateral lumbar radiograph showed osteopenia, exaggerated lumbar lordosis, mild platyspondyly of T11-12, anterior end-plate irregularity of T12, scalloping of the posterior end-plate of L3 (Figure 3).
AP hand radiographs in a 13-year-old boy with Klinefelter syndrome showed phalangeal preponderance (normally the length of the fourth metacarpal is equal to length of distal plus proximal phalanges).
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AP hands radiographs showed phalangeal preponderance (normally the length of the fourth metacarpal is equal to length of distal plus proximal phalanges) (Figure 4).
Lateral spine radiograph in a 3-year-old boy with MPS type IVA showed platyspondyly and oval-shaped vertebrae associated with dorsal wedging and deficient ossification of the anterior portions.
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Lateral spine radiograph showed platyspondyly and oval-shaped vertebrae associated with dorsal wedging and deficient ossification of the anterior portions (Figure 5).