PMC5506462_01
Case  2.
CRIOR2017-7402570.002.jpg
PMC5506462_01_CRIOR2017-7402570.002.jpg
fig2
MRI showed a diffuse-TGCT growth-pattern involving all compartments of the entire knee joint, including a Bakers cyst (Figures 2(a) and 2(b)).
PMC5506462_02
Case  3. Metal artefact reducing sequelae sagittal T2 weighted turbo inversion recovery MR image of the right knee of a 67-year-old male patient, with a TKR in situ. Extensive tumour progression around TKR and bone invasion is shown.
CRIOR2017-7402570.003.jpg
PMC5506462_02_CRIOR2017-7402570.003.jpg
fig3
Aggressive tumour progression, including bone involvement, provoked TKR failure (Figures 3, 4(a), and 4(b)).
Case  3. X-rays (anterior-posterior and sagittal) of failing total knee replacement, attributed to aggressive TGCT progression including bone involvement, after radiotherapy treatment.
CRIOR2017-7402570.004.jpg
PMC5506462_02_CRIOR2017-7402570.004.jpg
fig4
Aggressive tumour progression, including bone involvement, provoked TKR failure (Figures 3, 4(a), and 4(b)).
Case  3. PET-CT scan showing extensive TGCT around the right knee joint and multiple lung, pleural, and costal metastases. When pulmonary symptoms developed, an investigational tyrosine-kinase-inhibitor (TKI) was started ((a) prior to treatment; (b) after treatment), which had an effect on his pulmonary-metastases but not on his irradiated painful lymphedemic leg.
CRIOR2017-7402570.005.jpg
PMC5506462_02_CRIOR2017-7402570.005.jpg
fig5
When he developed pulmonary symptoms, an investigational TKI was started, which had an effect on his lung metastases but not on his irradiated painful lymphedemic leg (Figures 5(a) and 5(b)).
PMC5506462_03
Case  4. Knee-arthrodesis after multiple Dt-GCT surgeries in a 26-year-old man, using a compression plate and screws.
CRIOR2017-7402570.006.jpg
PMC5506462_03_CRIOR2017-7402570.006.jpg
fig6
During the following 13 years, the patient underwent a total of seven surgeries in an effort to treat Dt-GCT, including a knee-arthrodesis using a compression plate and screws (Figure 6).
Case  4. Sagittal T1 weighted Spectral Presaturation with Inversion Recovery MR image after intravenous contrast, of a 28-year-old male patient revealing a large, extra-articular TGCT tumour mass. Patients history describes multiple surgical treatments, including removal of osteosynthesis material for a knee-arthrodesis.
CRIOR2017-7402570.007.jpg
PMC5506462_03_CRIOR2017-7402570.007.jpg
fig7
Subsequently, a two-staged anterior and posterior debulking synovectomy was performed (Figure 7 shows MRI prior to debulking).