PMC5385972_01
Histopathology of the placenta. A photomicrograph showing areas with accelerated maturation-increased perivillous fibrin deposition (arrowheads), increased amount syncytial knots (arrow) and agglutinated villi (square). These pathological changes are characteristic for maternal vascular malperfusion. Hematoxylin and eosin staining X10.
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The placenta pathology showed signs of maternal vascular malperfusion with increased perivillous fibrin deposition and architectural disturbances without thrombosis (Figure 1).
Course of anti-dsDNA (squares) and IgA-beta2GPI (triangles) antibodies in the patient. The figure shows titers of anti-ds DNA (IU/ml) and IgA-beta2GPI (U/ml) antibodies during different checkpoints of the follow-up compared to each other. Threshold for high positivity (dotted line) was >= 40 IgA-beta2GPI U/ml. Bars represent standard deviations of the means. (*: P<0.05). Abbreviations: ART: assistant reproductive treatment.
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IgA-anti-beta2GPI showed statically significant decrease at the second and third trimester compared to other checkpoints. In addition, titres of IgA-anti-beta2GPI remained lower postpartum as well (Figure 2).