PMC9359805_01
(A and B) MRI of lumbar spine displayed partial cortical bone destruction and formation of abscesses at L4. (C) A chest CT scan demonstrated small round nodules with uneven density of upper right lung. The red arrow represents lesion.
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A chest CT scan demonstrated small round nodules with uneven density of upper right lung (Figure 1).
(A) Hematoxylin-eosin (HE) staining of the tissue sample from punch biopsy on L4 spine; the red arrow represents Cryptococcus. (B) Periodic acid-Schiff staining of the tissue sample from surgical biopsy on L4 spine.
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In addition, vastus lateralis by percutaneous needle biopsy under local anesthesia percutaneous puncture on L4 spine was performed, and postoperative pathology showed fungal-like structure and infiltration with chronic inflammatory cells in the tissues submitted for examination (Figure 2). CK (+), CD68(+), LCA (+), KI67 (+) (Figure 2). Cryptococcus neoformans var. grubii was confirmed from NGS data (Figure 3).
Next-generation sequencing (NGS) data.
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CK (+), CD68(+), LCA (+), KI67 (+) (Figure 2). Cryptococcus neoformans var. grubii was confirmed from NGS data (Figure 3).