PMC4149740_01
Gross view of the liver shows the three nodules. The upper right nodule and the lower one are HCC; the upper left one is CC.
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F1
The upper two masses though were very close to each other had not connection at all (Fig 1).
A) Nodule of HCC, B) nodule of CC (H&E x100)
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F2
Microscopic examination of the nodules showed three completely separated tumors:two typical for HCC and the other one typical for CC (Fig 2A, B).
A) IHC for HepPar-1 in CC nodule; B) IHC for HepPar-1 in HCC nodule; and C) IHC for MOC-31 in CC nodule
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F3
Immunohistochemical study showed positive HepPar-1 and paracanalicular CEA in one nodule and negative HepPar-1 and positive cytoplasmic CEA and CK7 and CK19 in the other nodule (Fig 3A, B, C).