PMC4994818_01
a Plain lumbar X-ray lateral view showing radiolucency of the L1 vertebral body. Sagittal (b) and axial (c) computed tomography showing an osteolytic lesion of the L1 vertebral body
40064_2016_3006_Fig1_HTML.jpg
PMC4994818_01_40064_2016_3006_Fig1_HTML.jpg
Fig1
Plain lumbar spine X-ray revealed a radiolucency at the L1 vertebral body (Fig. 1a). Computed tomography (CT) showed a defined osteolytic lesion involving the left side of the vertebral body and pedicle of L1 (Fig. 1b, c).
Sagittal magnetic resonance images showing low signal intensity changes of the L1 vertebral body on T1-weighted images (a) and high signal intensity changes on T2-weighted images (b). Axial magnetic resonance images showing low signal intensity changes of the L1 vertebral body and pedicle on T1-weighted images (c) and high signal intensity changes on T2-weighted images (d)
40064_2016_3006_Fig2_HTML.jpg
PMC4994818_01_40064_2016_3006_Fig2_HTML.jpg
Fig2
Magnetic resonance imaging (MRI) revealed low-signal intensity changes on T1-weighted images and high-signal intensity changes on T2-weighted images of the L1 vertebral body (Fig. 2).
a High-power photomicrography showing Langerhans histiocytes and mixed numerous eosinophils. b Neoplastic cells showing folded and convoluted nuclei with intra-nuclear groove resembling coffee beans (arrow). Immunohistochemical staining for S-100 protein (c) and CD-1a (d) showing immunoreactivity of Langerhans cells
40064_2016_3006_Fig3_HTML.jpg
PMC4994818_01_40064_2016_3006_Fig3_HTML.jpg
Fig3
Immunohistochemistry confirmed LCH with diffuse immunoreactivity of S-100 and CD1a (Fig. 3).
Sagittal (a) and axial (b) computed tomography a year after biopsy showing bone remodeling of the previous osteolytic lesion of the L1 vertebral body
40064_2016_3006_Fig4_HTML.jpg
PMC4994818_01_40064_2016_3006_Fig4_HTML.jpg
Fig4
Notably, follow-up CT revealed significant bone remodeling one year after biopsy, but the height of the vertebral body remained stable without further collapse, and lumbar kyphosis did not occur (Fig. 4).