PMC7102486_01
Haematoxylin and eosin stain (x20 magnification) showing (a) global to near global glomerulosclerosis, (b) collapsed glomerular tuft, (c) tubular microcystic dilatation, and (d) distended tubular epithelium from protein resorption droplets.
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fig1
The biopsy revealed collapsing glomerulosclerosis, tubular dilatation (Figure 1), tubuloreticular inclusions, thickened glomerular basement membrane, foot process effacement, and absence of electron dense deposits (Figure 2). 20 glomeruli were sampled, and 5 (25%) were globally sclerotic.
Electron microscopy (x35200-56200 magnification) showing (a) tubuloreticular inclusions (TRIs) in the endothelium of the glomerular capillaries, (b) thickened glomerular basement membrane with foot process effacement, and (c) absence of amorphous immune-type deposits (electron dense deposits).
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fig2
The biopsy revealed collapsing glomerulosclerosis, tubular dilatation (Figure 1), tubuloreticular inclusions, thickened glomerular basement membrane, foot process effacement, and absence of electron dense deposits (Figure 2). 20 glomeruli were sampled, and 5 (25%) were globally sclerotic.
Demonstration of the change in serum creatinine over time showing return to stable baseline CKD 4 after cART initiation with sCr of approximately 2 mg/dL.
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fig3
Haemodialysis was discontinued, and the patient remained in stage 4 CKD range (as demonstrated in Figure 3).