PMC9887464_01
Pathological examination. (A) Deep skin biopsy showing a septal dermohypodermatitis [haematoxylin and eosin (H&E) stain, x25). (B) Reactive fibrotic and necrobiotic subcutaneous nodule (H&E stain, x50). (C) Skin biopsy and nodule showing many non-foamy macrophages (H&E stain, x200). (D) Non-foamy macrophages whose cytoplasm contained multiple PAS-positive intracytoplasmic granulations, highly suggestive of T. whipplei (PAS stain, x200)
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In the dermis and hypodermis, there were many non-foamy macrophages, expressing CD68 in immunohistochemistry, whose cytoplasm contained multiple periodic acid-Schiff (PAS)-positive intracytoplasmic granulations (Fig. 1).