PMC4508752_01
Preoperative magnetic resonance (MR) scans of patient 1 with contrast enhancement (A, B) showing an enhancing mass lesion in tectum and hydrocephalus. MR scans with contrast enhancement after radiotherapy and chemotherapy (C) showing complete response of the tumor to the treatment. MR scans of patient 2 with contrast enhancement (D, E) showing an enhancing suprasellar and intrasellar mass lesion. MR scans with contrast enhancement after radiotherapy and chemotherapy (F) showing complete response.
nmc-53-703-g1.jpg
PMC4508752_02_nmc-53-703-g1.jpg
F1
Magnetic resonance imaging with contrast enhancement showed an intrasellar and suprasellar mass lesion infiltrating into left cavernous sinus and Meckel's cave, which was enhanced heterogeneously (Fig. 1D, E). The intrasellar and suprasellar mass disappeared completely on MRI (Fig. 1F).
Light micrographs of the resected tumors of patient 1 (A) and patient 2 (B-D) showing large polygonal cells with large nuclei and lymphocytic infiltrates as "two-cell pattern" geminomas (A, B) and tumor cells positive for placental alkaline phosphatase (PLAP) (C) and C-kit (D) as characteristic features of germinomas. A, B: Hematoxylin and eosin stain, original magnification x400. C: PLAP immunohistochemical stain, original magnification x400. D: C-kit immunohistochemical stain, original magnification x400. Scale bar = 50 mum in A.
nmc-53-703-g2.jpg
PMC4508752_02_nmc-53-703-g2.jpg
F2
An elastic grayish tumor was partially removed and diagnosed as pure germinoma, with a biphasic population of lymphocytes and larger polygonal cells that were positive for placental alkaline phosphatase and C-kit (Fig. 2B-D).
PMC4508752_02
Preoperative magnetic resonance (MR) scans of patient 1 with contrast enhancement (A, B) showing an enhancing mass lesion in tectum and hydrocephalus. MR scans with contrast enhancement after radiotherapy and chemotherapy (C) showing complete response of the tumor to the treatment. MR scans of patient 2 with contrast enhancement (D, E) showing an enhancing suprasellar and intrasellar mass lesion. MR scans with contrast enhancement after radiotherapy and chemotherapy (F) showing complete response.
nmc-53-703-g1.jpg
PMC4508752_02_nmc-53-703-g1.jpg
F1
Magnetic resonance imaging with contrast enhancement showed an intrasellar and suprasellar mass lesion infiltrating into left cavernous sinus and Meckel's cave, which was enhanced heterogeneously (Fig. 1D, E). The intrasellar and suprasellar mass disappeared completely on MRI (Fig. 1F).
Light micrographs of the resected tumors of patient 1 (A) and patient 2 (B-D) showing large polygonal cells with large nuclei and lymphocytic infiltrates as "two-cell pattern" geminomas (A, B) and tumor cells positive for placental alkaline phosphatase (PLAP) (C) and C-kit (D) as characteristic features of germinomas. A, B: Hematoxylin and eosin stain, original magnification x400. C: PLAP immunohistochemical stain, original magnification x400. D: C-kit immunohistochemical stain, original magnification x400. Scale bar = 50 mum in A.
nmc-53-703-g2.jpg
PMC4508752_02_nmc-53-703-g2.jpg
F2
An elastic grayish tumor was partially removed and diagnosed as pure germinoma, with a biphasic population of lymphocytes and larger polygonal cells that were positive for placental alkaline phosphatase and C-kit (Fig. 2B-D).