PMC9201904_01
Skin lesion prior to HSCT (A-C, H-J), at conditioning (D, K), and post-HSCT (E-G, L, M) of patient 1 (upper panel) and patient 2 (lower panel). Pictures of patient 1 were taken at age 8.5 (A), 9.3 (B) and 10.1 (C) years, and day +4 (E), +18 (F), and +36 (G) after HSCT. Pictures of patient 2 were taken at age 4.7 (H), 5.6 (I), 5.7 (J) years, at conditioning (K), and at day +5 (L), and +15 (M) after HSCT.
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She had also suffered from a progressive granulomatous skin lesion on the left upper arm since the age of three years ( Figures 1H-J ). HSCT was offered as a therapeutic option once local destructive growth of the lesion ( Figure 1J ) with increasing pain and pruritus occurred. HSCT ( Figures 1L, M , no pictures were taken after day 15), the first signs of resolution were already seen during conditioning. However, HSCT was complicated by severe and therapy-refractory hepatic veno-occlusive disease (VOD).