PMC10354362_01
(A, B) bladder tumor, (C, D) lung cancer.
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Chest CT examination suggested space-occupying lesions in the lower lobe of the lung, suggesting peripheral lung cancer with cervical, mediastinal and hilar lymph node metastases ( Figure 1 ).
Bladder Tumor IHC: HE stain (A), The panels mean that CK7 (B), Napsin A (D), and TTF-1 (F) are positive, While GATA3 (C), pax8 (E) are negative(original magnification 100X). Pleural effusion tissue IHC: HE stain (a). The panels mean that CK7 (b), Napsin A (d), and TTF-1 (f) are positive, While GATA3 (c), pax8 (e) are negative(original magnification 100X).
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Figure 2 ). For the left pleural effusion, puncture and drainage were performed and sent for pathology. CR (-); CK5/6 (-); CD163 (-); and PAX-8 (-)( Figure 2 ). Given the patient's medical history, pathological findings and immunohistochemistry, bladder metastasis of lung adenocarcinoma was considered. Color ultrasound-guided thoracentesis and drainage of pleural effusion were performed, and the bladder mass was submitted for genetic testing.
Timeline of clinical events.
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The patient agreed to the treatment and achieved one-year survival ( Figure 3 ), which was better than expected based on other studies.