PMC10105325_01
Pathology of patient case 1.
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F1
Histological examination of a brain biopsy confirmed the diagnosis of DLBCL (shown in Fig. 1).
MRI scans of the brain for patient one. a indicates the centrum semiovale and paraventricular violated at diagnosis. b shows tumor disappearing after one induction and two consolidation treatment based on MTX. c illustrates constant tumor negative after receiving zanubrutinib for 9 months.
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F2
So far, the man stays alive (shown in Fig. 2).
PMC10105325_02
Pathology of patient case 2.
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F3
Histology and IHC analysis revealed a DLBCL (shown in Fig. 3) with CD20, CD79a, MUM1 positive, Ki-67 positivity (approximately 60%), and BCL-6, CD21, and CD10 negative.
MRI scans of the brain for patient two. a indicates the right frontal cortex was violated at diagnosis. b shows tumor melting after one induction treatment. c illustrates cancer minimizing with 4 months of zanubrutinib treatment.
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F4
Three months after treatment, an MRI estimated that the tumor had shrunk and the patient could walk independently (shown in Fig. 4).