PMC7732491_01
The pig at the end of the procedure. The FTP 75 mug/h was covered with a surgical adhesive dressing. It was planned to be left in situ until the end of experiment at Day 8, but it had become dislodged and was presumably ingested at the most 4 h before the signs of intoxication were observed on Day 5. FTP, fentanyl transdermal patch.
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F1
The patch was covered with a surgical adhesive dressing (Figure 1).
Timeline of events that happened on the day of intoxication of the pig with FTP 75 mug/h. Ingestion of the FTP could not be confirmed, however, the intoxication due to ingestion of FTP was suspected, and the pig was treated with naloxone. FTP, fentanyl transdermal patch.
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F2
Approximately 10 min later, the pig rose to its feet, and within an hour normal behavior was restored (Figure 2).
Concentration-vs.-time profile of fentanyl absorbed from a 75 mug/h FTP. On Day 5 (120 h) there was a sharp rise in plasma fentanyl concentration due to ingestion of the FTP. FTP, fentanyl transdermal patch.
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F3
Fentanyl was slowly absorbed through the skin, reaching a maximal plasma concentration (Cmax) of 0.492 ng/ml at 36 h (Tmax, time at which Cmax is observed) post administration (Figure 3).