PMC9556971_01
Fundus findings of panuveitis at the time of onset. Color fundus photographs show bullous SRDs in the posterior retina (areas of orange dotted circles), redness and swelling of the optic disc (white arrows) in (A) the right eye and (B) the left eye. EDI-OCT images reveal SRDs (yellow asterisks), cystoid spaces in the neurosensory layer of the retina (white asterisks), choroidal thickening (blue dotted lines) in (C) the right eye and (D) the left eye. FA images indicate multiple punctate fluorescein leaks (yellow arrowheads) and pooling (yellow asterisks) consistent with the SRD locations, and hyperfluorescence of the optic disc in (E) the right eye and (F) the left eye. IA images present dark patches (blue arrowheads) in (G) the right eye and (H) the left eye. The time of photography after administration of FA or IA is indicated in the lower right corner. Scale bars (white vertical bar) in (C, D), 200 mum. EDI-OCT; enhanced depth imaging optical coherence tomography; FA, fluorescein angiography; IA, indocyanine green angiography; SRD, serous retinal detachment.
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Figure 1 ). SRDs, cystoid spaces in the neurosensory layer of the retina, and choroidal thickening were revealed by enhanced depth imaging optical coherence tomography. Fluorescein angiography (FA) images indicated multiple punctate fluorescein leakages and pooling consistent with the SRD locations, and hyperfluorescence of the optic disc. In the clinical course of treatment ( Supplementary Figure 1 ), we paid attention to deterioration of visual acuity and subfoveal choroidal thickness, and tapered the dose of prednisolone in accordance with the assessment of uveitis activity proposed by The standardization of Uveitis Nomenclature (SUN) Working Group.
Hierarchical cluster analysis of cellular phenotypes in the patient and the healthy control. In the heatmap, the vertical axis shows 37 types of immune cells in peripheral blood mononuclear cells. The horizonal axis shows four samples: Pre-P; patient not receiving GC therapy at the time of onset, Post-C; healthy control one month after the third dose of BNT162b2 vaccine, Pre-C; healthy control before BNT162b2 vaccination, Post-P; patient receiving GC therapy combined with CsA in the inactive phase. Hierarchical cluster analysis was performed using Euclidean distance as a distance measure and Ward's method for hierarchical clustering. Color scale: low values, red; middle to high values, black to green.
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Fundus findings in the inactive phase are presented in  Supplementary Figure 2 . Next, immune cell populations and cellular phenotypes in peripheral blood mononuclear cells were examined ( Table 2  and  Figure 2 ). T cells, CD4+ naive T cells, CD4+ terminal effector T cells, Th1-like cells, and Th2-like cells were relatively high in Pre-C. The heat map ( Figure 2 ) displaying the distribution of immune cell populations in the four samples indicated that the immune profile of Pre-P was not similar in properties to the profiles of the other three samples (Pre-C, Post-C and Post-P), while there was a high property similarity between the immune profiles of Pre-C and Post-P.