PMC5238517_01
Fundus examination showed a flat demarcation-like line in retinal periphery (a). FA images showed areas of capillary non-perfusion and arteriovenous shunting in what appeared to be mature retinal vessels (b, c). The patient was placed on rigorous monitoring and intensive regulation of oxygen. She was reassessed 1 week later (38 weeks). Fundus examination revealed formation of new vessels and patches ("islands") of leaking vessels (d). Twelve weeks later, weekly screening showed that vessels continued growing toward the periphery (e). This patient was classified as group 1
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Fig2
The patient was screened for ROP at 37 weeks of gestational age (Fig. 2). 
Image a shows an elevated demarcation line. Image b shows microaneurysms or tufts posterior to the ridge along with discrete leakage of fluorescein at the ridge (white arrow). There are also vasoobliterative and capillary free areas (circle). Of note is that the demarcation line is irregular and we can find capillary free islands posterior to the ridge
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Fig3
Fundus examination showed neovascularization in zone 1 (along temporal vascular arcades), extensive areas of capillary drop-out, subhyaloid and vitreous hemorrhages and macular fibrosis (a, b). FA of right eye shows vascular tortuosity and leakage secondary to neovascularization (c). The patient was classified as group 2
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Fig4
He had sepsis during hospitalization (Fig. 4).