PMC8192798_01
Computed tomography (A: axial, C: coronal, D: sagittal) of the chest showed a mass in the posterior mediastinum (red arrow). The enhancement scan (B) was uneven and slightly enhanced.
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F1
Enhanced computed tomography (CT) (Philips, Brilliance ICT CP 200063) of the chest showed a 3.5 x 3.1-cm mass in the posterior mediastinum, and no other lesions were identified in the thoracic cavity (Figure 1).
(A) Hematoxylin-eosin staining showed that epithelioid angiosarcoma had abundant eosinophilic cytoplasm and vesicular nuclei, with prominent nucleoli (red arrow) (200x). (B) Hematoxylin-eosin staining showed that the schwannoma cells were spindle, with abundant cytoplasm and insignificant nucleoli, which were arranged in a palisade shape (red arrow) (40x). (C) Epithelioid tumor cells stained positive for CD-31 (100x). (D) Spindled schwannian cells were diffusely positive for SOX-10 (200x).
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F2
Pathological examination revealed the presence of angiosarcoma (Figure 2A) and schwannoma (Figure 2B) components. Immunohistochemical staining for cluster of differentiation (CD) 31 (Figure 2C), CD34, EGR, vimentin, SOX-10 (Figure 2D) and S-100 was strongly positive.
Two months postsurgery, the patient was followed up by chest CT and had no evidence of tumor recurrence.
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F3
Two months post-surgery, the patient returned for chest CT and had no evidence of tumor metastasis or recurrence (Figure 3 and see timeline in Figure 4).
Timeline of symptoms, investigation, and treatment.
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F4
Two months post-surgery, the patient returned for chest CT and had no evidence of tumor metastasis or recurrence (Figure 3 and see timeline in Figure 4).