PMC184446_01
Fine needle aspiration cytology of the right parotid mass showing numerous polymorphic lymphocytes. (medium high power x 550; Diff Quick stain).
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F1
Cytology of the fine needle aspiration of the parotid mass showed numerous polymorphic lymphocytes (Figure 1).
Crystalline inclusion bodies in tissue section with PAS stain Periodic-Acid-Schiff Staining (medium power x 250) reveals sheets of neoplastic plasma cells with multiple intracytoplasmic crystalline inclusion bodies both within the plasma cells and the adjacent histiocytes.
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F2
Detailed pathological analysis showed sheets of plasma cells and plasmacytoid cells with a fair number of the plasma cells and histiocytes containing crystalline inclusion bodies many of which were linearly profiled and of multiple shapes (Figure 2, 3).
Electron microscopic analysis of crystalline inclusions. Ultrastructural analysis of these crystalline inclusions is demonstrated (scale 1.70 cm = 300 nm at x 5675)
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F3
Detailed pathological analysis showed sheets of plasma cells and plasmacytoid cells with a fair number of the plasma cells and histiocytes containing crystalline inclusion bodies many of which were linearly profiled and of multiple shapes (Figure 2, 3).
Immunohistochemical analysis Immunohistochemical staining shows the plasma cells to be IgG positive with kappa restriction pattern (medium power x 250)
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F4
Immuno-histochemical staining showed the plasma cells to be monoclonal (kappa restricted) and the small lymphoid cells in the background to be predominantly T-cells (CD45RO+), along with a smaller proportion of B-cells (CD20+) (Figure 4).