PMC8529084_01
A dark reddish, non-blanching, maculopapular rash was visible on the trunk and extremities of the patients (a, b). The characteristic rash of patient 1 transformed into ecchymosis (c) in convalescence stage.
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PMC8529084_01_gr1.jpg
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Both patients had fever, asthenia, severe headache, and anorexia and displayed lymphadenopathy and characteristic rash manifested as dark reddish spots (Fig. 1a,b). The characteristic rash of patient 1 transformed into ecchymosis (Fig. 1c) in convalescence stage. (Fig. 1).
Eschar visible on the skin of the lateral surface of the right thigh of patient 2.
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PMC8529084_01_gr2.jpg
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Patient 2 had eschars (Fig. 2), but neither of them had any severe complications (i.e. respiratory failure; or hemorrhagic or neurological signs or symptoms) (Table 1).
a: BIast Comparison results of the Detected SFGR 50 bp sequences of patient 1. b: BIast Comparison results of the Detected SFGR 50 bp sequences of patient 2.
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PMC8529084_01_gr3b.jpg
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Six 50 bp Rickettsia fragments from the two patients were aligned with the reference database, and the results showed that all six fragments were consistent with the gene library of Rickettsia japonica (Fig. 3a, b).