PMC8488423_01
Localized well-defined moist, erythematous and whitish eroded plaques on the anogenital region.
cde-0013-0176-g01.jpg
PMC8488423_01_cde-0013-0176-g01.jpg
F1
Physical examination revealed localized well-defined moist, erythematous and whitish eroded plaques on bilateral labia majora, labia minora, clitoris, posterior fourchette, right anterior part of the anus, as well as bilateral perineal and inguinal areas without urethral involvement (Fig. 1).
Epidermal proliferation with nests of clear cell neoplasm with pagetoid spreading through the epidermis with flattened basal cell layer. H&E, 10x.
cde-0013-0176-g02.jpg
PMC8488423_01_cde-0013-0176-g02.jpg
F2
A tissue specimen examination, collected by incisional skin biopsy from the lesion at right inguinal area, showed epidermal proliferation with nests of clear cell neoplasm with pagetoid spreading through the epidermis with flattened basal cell layer lying between clear cell neoplasm and the underlying epidermis (Fig. 2).
PMC8488423_02
Localized well-defined erythematous and whitish eroded plaques on the anogenital area.
cde-0013-0176-g03.jpg
PMC8488423_02_cde-0013-0176-g03.jpg
F3
Physical examination revealed localized well-defined erythematous and whitish eroded plaques on bilateral labia majora, labia minora extending to the perianal area (Fig. 3) without urethral, clitoral, and vaginal involvement.
Epidermal proliferation with large rounded atypical cells with clear ample-staining cytoplasm scattered through the epidermis with flattened basal cell layer.
cde-0013-0176-g04.jpg
PMC8488423_02_cde-0013-0176-g04.jpg
F4
A biopsy specimen showed epidermal proliferation with large rounded atypical cells with clear ample-staining cytoplasm scattered through the epidermis with flattened basal cell layer lying between atypical cells and the underlying epidermis (Fig. 4).