PMC6417350_01
(a) Magnetic resonance imaging shows well-circumscribed intramedullary space-occupying lesion at C6-D2 level. (b) Scanner view shows large papillary structures with fibrovascular core having cells attached to blood vessels in multiple layers (H and E). (c) Low power view shows cohesive clusters of round to oval cells with bland nuclei (H and E). (d) High power view of cells show chromatin of salt and pepper type (MGG)
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F1
C6-D2 region with contrast enhancement [Figure 1a]. Complete excision of the tumor was done. In some places, thick bottle brush appearance was noted [Figure 1b-d].
(a) Low power view shows well-formed papillae and finger-like projections. Inset shows vessels lined by layers of tumor cells (H and E). (b) High power view shows papilla lined by single or multiple layers of tumor cells. True rosettes can also be seen (H and E). (c) Tumor cells show strong positivity for glial fibrillary acid protein. Inset shows glial fibrillary acid protein positivity at high power. (d) Tumor cells show apical membrane positivity for EMA. Inset shows the same at high power
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F2
The tumor stained strongly for glial fibrillary acidic protein (GFAP) which was highlighted in the processes of perivascular pseudorosettes [Figure 2a-c]. Epithelial membrane antigen (EMA) showed apical membrane positivity [Figure 2d].