PMC9800527_01
Case 1: Incidental finding at the fimbrial end, H&E x2 (a); Large cells with small round nuclei and copious eosinophilic cytoplasm, H&E x5 (b) and H&E x40 (c). Case 2: Scattered neoplastic cells showing a pale and strikingly vacuolated cytoplasm, H&E x10 (d); Focal capsular invasion, H&E x5 (e); Focus suspicious of lymphovascular space invasion, H&E x2 (f); The immunohistochemistry shows strong diffuse positivity for Calretinin, x0.5 (g), Inhibin, x0.5 (h) and CD99, x0.5 (i).
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PMC9800527_02_gr1.jpg
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Scattered neoplastic cells showed a pale and strikingly vacuolated cytoplasm (Fig. 1d). A focus suspicious of lymphovascular space invasion was seen (Fig. 1e). Focal capsular invasion was present (Fig. 1f). The immunohistochemistry shows strong diffuse positivity for Calretinin (Fig. 1g), Inhibin (Fig. 1h) and CD99 (Fig. 1i) and negativity for HMB-45, Melan-A, S-100 and AE1/AE 3.
PMC9800527_02
Case 1: Incidental finding at the fimbrial end, H&E x2 (a); Large cells with small round nuclei and copious eosinophilic cytoplasm, H&E x5 (b) and H&E x40 (c). Case 2: Scattered neoplastic cells showing a pale and strikingly vacuolated cytoplasm, H&E x10 (d); Focal capsular invasion, H&E x5 (e); Focus suspicious of lymphovascular space invasion, H&E x2 (f); The immunohistochemistry shows strong diffuse positivity for Calretinin, x0.5 (g), Inhibin, x0.5 (h) and CD99, x0.5 (i).
gr1.jpg
PMC9800527_02_gr1.jpg
f0005
Scattered neoplastic cells showed a pale and strikingly vacuolated cytoplasm (Fig. 1d). A focus suspicious of lymphovascular space invasion was seen (Fig. 1e). Focal capsular invasion was present (Fig. 1f). The immunohistochemistry shows strong diffuse positivity for Calretinin (Fig. 1g), Inhibin (Fig. 1h) and CD99 (Fig. 1i) and negativity for HMB-45, Melan-A, S-100 and AE1/AE 3.
PMC9800527_03
Case 3 Areas of necrosis, H&E x2 (a) and H&E x20 (b); Mitosis, H&E, x40 (c); The tumour cells show strong, diffuse expression of Calretinin, x2 (d), CD99, x5 (e), Inhibin, x10 (f); Reticulin stain shows deposition around nests of tumour cells and individual cells, x20 (g).
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Multiple small areas of necrosis were present (Fig. 2a, b) and there was significant mitotic activity with several mitoses within a single high-power field (Fig. 2c). Immunohistochemically there was diffuse positive staining with Calretinin (Fig. 2d), CD99 (Fig. 2e) and Inhibin (Fig. 2f) and focal staining with CK7. A reticulin stain showed deposition around nests of tumour cells and individual cells (Fig. 2g).