PMC6593915_01
Demonstrating the four generations of affected members of the family pedigree (y: Years).
NCI-6-176-g001.jpg
PMC6593915_01_NCI-6-176-g001.jpg
F1
The cases were listed by their location in the pedigree (Fig. 1).
Left eye corneal photograph of Case 1. Opacities of granular corneal dystrophy were seen in the corneal stroma.
NCI-6-176-g002.jpg
PMC6593915_01_NCI-6-176-g002.jpg
F2
BCVA was 20/20 unaided bilaterally. Bilateral slit lamp biomicroscopy revealed symmetrical, sharply demarcated, non-coalescent, grayish-white opacities only in the stroma layer (Fig. 2).
(A) Subclinical keratoconus findings in the right eye topograph of Case 1 (mother of the proband). (B) Subclinical keratoconus findings in the left eye topograph of Case 1 (mother of the proband).
NCI-6-176-g003.jpg
PMC6593915_01_NCI-6-176-g003.jpg
F3
She was diagnosed with bilateral subclinical keratoconus by topographic examination according to Ucakhan et al. (Fig. 3A, Fig. 3B).
Right eye photograph of the proband (Case 4). Sharply demarcated, grayish-white, non-coalescent, star-shaped opacities localized only to the stroma.
NCI-6-176-g004.jpg
PMC6593915_01_NCI-6-176-g004.jpg
F4
Corneal ectasia with the presence of Vogt's striae and a Fleischer's ring and sharply demarcated, grayish-white, non-coalescent, star-shaped opacities localized only to the stroma were found bilaterally on biomicroscopic examination (Fig. 4).
(A) Keratoconus findings in the right eye topograph of the proband (Case 4). (B) Keratoconus findings in the left eye topograph of the proband (Case 4).
NCI-6-176-g005.jpg
PMC6593915_01_NCI-6-176-g005.jpg
F5
She was diagnosed with bilateral clinical keratoconus by topographic examination (Fig. 5A, Fig. 5B).
Left eye corneal photograph of Case 7. Opacities of granular corneal dystrophy were seen in the corneal stroma.
NCI-6-176-g006.jpg
PMC6593915_01_NCI-6-176-g006.jpg
F6
Similar to other cases, bilateral and symmetrical, sharply demarcated, grayish-white, non-coalescent, star-shaped specular mild opacities were seen only in the stroma layer on biomicroscopic examination (Fig. 6).
(A) Subclinical keratoconus findings in the right eye topograph of Case 7 (daughter of the proband). (B) Subclinical keratoconus findings in the left eye of Case 7 (daughter of the proband).
NCI-6-176-g007.jpg
PMC6593915_01_NCI-6-176-g007.jpg
F7
She was diagnosed with bilateral subclinical keratoconus by topographic examination (Fig. 7A, Fig. 7B).