PMC5161784_01
A polyp in the sigmoid colon found during colonoscopy showing overlying red mucosa.
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The patient underwent colonoscopy, which revealed a sessile polyp in the sigmoid colon measuring about 5-10 mm in size with overlying red mucosa (Fig. 1).
(a) Low-magnification (4x) hematoxylin and eosin section of the 5-mm sigmoid colon biopsy specimen showing multiple focal granuloma formation surrounding Schistosoma mansoni eggs in the lamina propria and submucosa of the colonic wall with surrounding fibrosis. (b) Intermediate-magnification (10x) hematoxylin and eosin section of the same specimen showing hyperplastic colonic mucosa with focal granuloma formation due to Schistosoma mansoni eggs accompanied by hemorrhages in the submucosa. (c) High-magnification (40x) hematoxylin and eosin section of the colonic mucosa showing one granuloma with Schistosoma eggs with characteristic lateral spine, suggesting of Schistosoma mansoni. Surrounding the eggs are fibrosis and chronic inflammatory cells, consistent with chronic colonic schistosomiasis.
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Hematoxylin and eosin section of the biopsy specimen showed non-neoplastic colonic mucosa and a hyperplastic polyp with multiple focal granuloma formation surrounding S. mansoni eggs, which were characterized by prominent lateral spine in the lamina propria and submucosa of the colonic wall with surrounding fibrosis (Fig. 2a-c). Hemorrhage in the submucosa was seen (Fig. 2b).