PMC8216389_01
CT scans (A: at baseline; B: after 8 weeks and C: after 16 weeks from the beginning of the treatment) showing the appearance of 2 enlarging lesions in the chest wall close to the biopsied lesion.
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After 5 cycles, he started a third-line treatment with nivolumab, and unfortunately, the first CT scan assessment reported disease progression (Figure 1A). The first subsequent CT scan in February 2020 showed stable disease according to RECIST (Response Evaluation Criteria In Solid Tumours) 1.1, with the appearance, however, of a couple of small (maximum diameter 8 mm), contiguous nodules in the thoracic wall, close to the biopsied lesion (Figure 1B). The subsequently CT scan showed enlargement of all the pulmonary and nodal lesions and huge increase of the dimensions of the nodules in the thoracic wall previously described, that spread from the subpleural space to the skin (Figure 1C).