PMC4822807_01
A well-circumscribed amelanotic iris mass with underlying multiple posterior pigment epithelial cysts.
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Slit-lamp biomicroscopy in the right eye revealed an oval, yellowish, highly vascularized iris mass with 6 mm horizontal diameter and 10 mm vertical diameter extending from the 4:00 to 11:00 positions (Figure 1).
UBM revealed a hypoechoic mass coalesced with iris stroma with 5.6 mm horizontal diameter and 9.3 mm vertical diameter.. Abbreviation: UBM, ultrasound biomicroscopy.
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Ultrasound biomicroscopy revealed a hypoechoic mass coalesced with iris stroma and multiple underlying posterior iris pigment epithelial cysts (Figure 2).
Histopathology and Immunohistochemical stain.. Notes: (A) Histopathology of the surgical specimen showing attached iridic tissue (H&E x40). (B) Tumor cells having plump shape and epithelioid appearance with mildly pleomorphic and vesicular nuclei (H&E x400). (C) Immunohistochemical stain for alpha smooth muscle actin (IHC x100). (D) In situ hybridization for EBER shows positive reaction (EBER x400).. Abbreviations: EBER, Epstein-Barr virus-encoded RNA; H&E, hematoxylin and eosin; IHC, immunohistochemistry.
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In situ hybridization for EBV-encoded ribonucleic acid revealed a positive reaction in most regions of the tumor (Figure 3).
Final slit-lamp biomicroscopy at 8 months revealed the absence of tumor recurrence.
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The visual acuity was 20/25 OD (Figure 4).