PMC6249337_01
Pedigree of the family. The arrow indicates the proband. Circles indicate females, squares indicate males. The diagonal line indicates a deceased family member. Black squares/circles indicate a carrier of the FHM3 (c.4495T>C) mutation with hemiplegic migraine. White squares/circles indicate subjects that are neither patients nor mutation carriers.
fneur-09-00976-g0001.jpg
PMC6249337_03_fneur-09-00976-g0001.jpg
F1
The proband's nephew (Figure 1, III-1), a 25-year-old fitness coach, had first headache attacks with visual symptoms (scotomata) and lateralized motor weakness at the age of 13.
MRA and MRI images of the female patient show no meaningful abnormalities.
fneur-09-00976-g0002.jpg
PMC6249337_03_fneur-09-00976-g0002.jpg
F2
After admission, her neurological examinations were unremarkable and brain magnetic resonance imaging (MRI) and Magnetic Resonance Angiography (MRA) showed no meaningful abnormalities (Figure 2).
The next-generation sequencing results of exon 26 of the gene SCN1A in members of this family. (A) Proband with the T   C mutation, (B) the proband's unaffected son without the T   C mutation, (C) the proband's brother with the T   C mutation, (D) the proband's unaffected granddaughter without the T   C mutation.
fneur-09-00976-g0003.jpg
PMC6249337_03_fneur-09-00976-g0003.jpg
F3
We only found a gene mutation in SCN1A, but this mutation was detected in all affected subjects in this family (Figure 3).
PMC6249337_02
Pedigree of the family. The arrow indicates the proband. Circles indicate females, squares indicate males. The diagonal line indicates a deceased family member. Black squares/circles indicate a carrier of the FHM3 (c.4495T>C) mutation with hemiplegic migraine. White squares/circles indicate subjects that are neither patients nor mutation carriers.
fneur-09-00976-g0001.jpg
PMC6249337_03_fneur-09-00976-g0001.jpg
F1
The proband's nephew (Figure 1, III-1), a 25-year-old fitness coach, had first headache attacks with visual symptoms (scotomata) and lateralized motor weakness at the age of 13.
PMC6249337_03
Pedigree of the family. The arrow indicates the proband. Circles indicate females, squares indicate males. The diagonal line indicates a deceased family member. Black squares/circles indicate a carrier of the FHM3 (c.4495T>C) mutation with hemiplegic migraine. White squares/circles indicate subjects that are neither patients nor mutation carriers.
fneur-09-00976-g0001.jpg
PMC6249337_03_fneur-09-00976-g0001.jpg
F1
The proband's nephew (Figure 1, III-1), a 25-year-old fitness coach, had first headache attacks with visual symptoms (scotomata) and lateralized motor weakness at the age of 13.
MRA and MRI images of the female patient show no meaningful abnormalities.
fneur-09-00976-g0002.jpg
PMC6249337_03_fneur-09-00976-g0002.jpg
F2
After admission, her neurological examinations were unremarkable and brain magnetic resonance imaging (MRI) and Magnetic Resonance Angiography (MRA) showed no meaningful abnormalities (Figure 2).
The next-generation sequencing results of exon 26 of the gene SCN1A in members of this family. (A) Proband with the T   C mutation, (B) the proband's unaffected son without the T   C mutation, (C) the proband's brother with the T   C mutation, (D) the proband's unaffected granddaughter without the T   C mutation.
fneur-09-00976-g0003.jpg
PMC6249337_03_fneur-09-00976-g0003.jpg
F3
We only found a gene mutation in SCN1A, but this mutation was detected in all affected subjects in this family (Figure 3).