PMC5161798_01
Graph depicting creatinine trend. The arrow points to the day when high-dose steroid therapy was initiated.
JCHIMP-6-32976-g001.jpg
PMC5161798_01_JCHIMP-6-32976-g001.jpg
F0001
In spite of adequate hydration, the patient's renal function continued to deteriorate, and serum creatinine peaked at 7.5 mg/dl on day 4 (Fig. 1).
(a) H&E stainx100: Core biopsy showing a small focus of interstitial hemorrhage in the corticomedullary junction (pointed by the arrow). (b) H&E stainx200: Core biopsy showing renal cortex with diffuse interstitial inflammation consisting of mainly lymphocytes, plasma cells, and sparse eosinophils. A congested but otherwise unremarkable glomerulus (pointed by the arrow) and a cluster of proximal tubules, few of which contain red cell casts, can be seen in the background.
JCHIMP-6-32976-g002.jpg
PMC5161798_01_JCHIMP-6-32976-g002.jpg
F0002
AIN (Fig. 2a and b). A skin biopsy of the rash was compatible with perifolliculitis and superficial perivascular dermatitis.