PMC5109571_01
a: Radiograph of the right lower tibial shaft displays narrow radiolucent lines measuring 2 to 4 mm in width with sclerotic borders (arrow), thus indicating a pseudofracture pattern known as Looser zones. b: Bone scintigraphy with 99mTc-labeled methylene diphosphonate (MDP) demonstrates a high uptake in the bilateral ankles to distal tibiae (including the pseudofracture of the lower tibial shaft), knees, and ribs. c: Clinical course.
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These were more prominent in the right leg (Fig. 1a). Bone scintigraphy with 99mTc-labeled methylene diphosphonate (MDP) demonstrated a high uptake in the bilateral ankles to distal tibiae (including the pseudofractures of the lower tibial shaft), knees, and ribs (Fig. 1b). The serum p level became less than 2.0 mg/dL at 20 months after the administration of ADV, while bone pain occurred at 52 months, and bone biopsy was done at 56 months (Fig. 1c).
PMC5109571_02
a: A bilateral femoral neck fracture (arrows) occurred suddenly without any precipitating cause. b: Clinical course.
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In addition to pain of the bilateral hip, ankle, and knee joints, a bilateral femoral neck fracture (Fig. 2a) suddenly occurred without any precipitating cause in June 2011. The serum p level became less than 2.0 mg/dL at 36 months after the administration of ADV, a bone fracture occurred at 56 months, and a bone biopsy was done at 70 months (Fig. 2b).