PMC10122845_01
(A and B) Symmetrical distribution of hypopigmented patches interspersed with punctate pigmentation on the dorsal skin of both fingers and freckle-like pigmentation on both cheekbones of the face, no blisters, papules, scales or other damage at the lesions, no pain, itching or other discomfort.
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Dermatologic examination revealed symmetrical distribution of hypopigmented patches interspersed with punctate pigmentation on the dorsal skin of both fingers and freckle-like pigmentation on both cheekbones of the face, no blisters, papules, scales or other damage at the lesions, no pain, itching or other discomfort (Figure 1A and B).
(A and B) Skin CT: Compared to the surrounding normal skin, the pigment ring in the basal layer of the leukoplakic area was completely absent, and no inflammatory cell infiltration was seen in the dermal papillae, with clear boundaries to the surrounding normal skin.
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Skin CT showed: Compared to the surrounding normal skin, the pigment ring in the basal layer of the leukoplakic area was completely absent, and no inflammatory cell infiltration was seen in the dermal papillae, with clear boundaries to the surrounding normal skin (Figure 2A and B).
Family tree of dyschromatosis symmetrica hereditaria, glucose-6-phosphate dehydrogenase deficiency, psychosis in four generations.
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Family investigation: parents were not consanguineously married, and in the patient's II generation III line, only the patient's mother had the same skin lesions as the patient on both hands and both cheekbones, with no other history of G6PD deficiency, except for a family history of psychiatric disorders in the patient's paternal line (Figure 3).