PMC515307_01
Solitary lesion over dorsum of left index finger.
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F1
Skin lesions consisted of scattered, white to skin-colored papules, less than 1 centimeter in diameter, and with central protrusion, that were distributed on the dorsum of fingers (Fig 1), forearms (Fig 2), distal portion of the thighs and on the calves (Fig 3).
An anetodermic lesion on forearm.
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F2
Skin lesions consisted of scattered, white to skin-colored papules, less than 1 centimeter in diameter, and with central protrusion, that were distributed on the dorsum of fingers (Fig 1), forearms (Fig 2), distal portion of the thighs and on the calves (Fig 3).
An anetodermic lesion on lateral aspect of left lower leg (before cryotherapy)
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F3
Skin lesions consisted of scattered, white to skin-colored papules, less than 1 centimeter in diameter, and with central protrusion, that were distributed on the dorsum of fingers (Fig 1), forearms (Fig 2), distal portion of the thighs and on the calves (Fig 3).
Anetoderma lesions some minute after cryotherapy
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F4
We tried to treat the patient with liquid nitrogen cryotherapy by means of cotton-tip applicator for two freeze-thaw cycles (freeze time, 10-15 seconds), in 6-8 sessions weekly; which obtained moderate improvement in some early-onset lesions with no frank atrophy (Fig 4 and 5).
The same view as Fig. 4 after several sessions of cryotherapy (the 2 lower lesions near completely been resolved).
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F5
We tried to treat the patient with liquid nitrogen cryotherapy by means of cotton-tip applicator for two freeze-thaw cycles (freeze time, 10-15 seconds), in 6-8 sessions weekly; which obtained moderate improvement in some early-onset lesions with no frank atrophy (Fig 4 and 5).
Faintly eosinophilic separated collagen bundles in upper dermis (H&E x250).
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F6
Haematoxylin and eosin stained section showed faintly eosinophilic separated collagen fibers in the upper and mid-dermis (Fig 6).
Severely decreased elastic fibres in superficial and mid dermis (Verhoeff-van Gieson stain x250).
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F7
Elastic fibres around the vessels in the affected areas are also fragmented and markedly decreased (Fig 7,8).