PMC6393929_01
(a, b) Bone marrow biopsy with extensive infiltration by atypical plasmacytoid cells (original magnifications: x100; x400). (c) The cells are positive for CD138 by immunohistochemistry, indicative of plasma cell differentiation (original magnification: x400). (d) Atypical plasmacytoid cells, including forms with plasmablastic morphology, as visualized on bone marrow aspirate smear (original magnification: x1000).
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fig1
Bone marrow biopsy (Figure 1) showed a hypercellular marrow (60-70%), with an infiltrate of markedly pleomorphic kappa-restricted monotypic plasmacytoid cells, many with immature features, comprising approximately 50% of overall cellularity (CD138+, kappa+, lambda-, CD117 focal+, CD56-, CD20-, and TdT-, by immunohistochemistry).