PMC8077485_01
Right unilateral periorbital oedema.
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F1
A 91-year-old Caucasian man presented to a general practice clinic in rural Victoria, Australia with a 4-week history of progressive facial oedema primarily affecting his right upper and lower eyelid, associated with a gritty sensation and clear discharge from his affected eye (Fig. 1).
Angiosarcoma (on the right) adjacent to SCC (on the left) with intervening normal sebaceous glands. The tumour consists of irregular anastomosing channels lined by markedly pleomorphic cells. The vessels dissect through the dermis, and the tumour is poorly circumscribed. This is a relatively well-differentiated area, so you can see the obvious vascular nature of the tumour.
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F2
The stains were positive with immunohistochemical vascular markers ERG, CD31, and CD34, and a high proliferation index with Ki67, revealing the diagnosis of extensive cAS (Fig. 2, 3).
ERG showing the tumour dissecting through the dermis into the subcutaneous fat. Note the above SCC does not stain for this marker, allowing clear distinction.
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F3
The stains were positive with immunohistochemical vascular markers ERG, CD31, and CD34, and a high proliferation index with Ki67, revealing the diagnosis of extensive cAS (Fig. 2, 3).