PMC8245756_01
Perioperative magnetic resonance imaging. The tumor showed isointensity on T1-weighted imaging (A) and slightly hyperintensity on T2-weighted imaging (B). After administration of contrast medium, the lesion was heterogeneously enhanced (C). Postoperative spinal MRI confirmed a subtotal resection of the tumor (D) coronal, (E) sagittal, (F) axial.
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F1
The lesion showed isointensity on T1-weighted imaging and slightly hyperintensity on T2-weighted imaging; after administration of contrast medium, the lesion was heterogeneously enhanced (Figures 1A-C). Postoperative spinal MRI confirmed a subtotal resection of the tumor (Figures 1D-F).
Histopathological examinations. (A) Hematoxylin and Eosin staining (x 200) showed diffusely distributed tumor cells with unobvious atypia and no karyokinesis. (B) Immunohistochemical staining (x 200) demonstrated that the tumor cells were positive for H3K27M mutant protein, and the positive site was located in the nucleus.
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F2
Pathological examination revealed that the density of tumor cells was moderate, the nucleus was irregular and slightly to moderately heteromorphic, and no karyokinesis was observed (Figure 2A). Immunohistochemistry showed the tumor harbored an H3 K27M mutation (Figure 2B).