PMC4763575_01
Erythematous plaque on the ulnar aspect of right hand
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F1
Dermatological examination showed a single well-defined erythematous plaque, 20 x 5 cm with raised borders on the ulnar aspect of right hand and distal forearm, extending to the palm [Figures 1 and 2].
Erythematous plaque extending to the palm
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F2
Dermatological examination showed a single well-defined erythematous plaque, 20 x 5 cm with raised borders on the ulnar aspect of right hand and distal forearm, extending to the palm [Figures 1 and 2].
Diffuse granulomas in the dermis (H and E, x40)
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F3
Histopathological examination showed dermal edema, diffuse granulomas composed of Langhans type giant cells, surrounded by epithelioid cells, lymphocytes, multinucleated giant cells, and fibroblasts with perivascular lymphocytic infiltrate, consistent with Hansen's disease borderline tuberculoid type, with features suggesting type 1 lepra reaction [Figures 3-6].
Dermal edema with Langhans giant cells, epithelioid cells and lymphocytes (H and E, x40)
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F4
Histopathological examination showed dermal edema, diffuse granulomas composed of Langhans type giant cells, surrounded by epithelioid cells, lymphocytes, multinucleated giant cells, and fibroblasts with perivascular lymphocytic infiltrate, consistent with Hansen's disease borderline tuberculoid type, with features suggesting type 1 lepra reaction [Figures 3-6].
Section under high-power showing diffuse dermal edema and granulomas (H and E, x40)
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F5
Histopathological examination showed dermal edema, diffuse granulomas composed of Langhans type giant cells, surrounded by epithelioid cells, lymphocytes, multinucleated giant cells, and fibroblasts with perivascular lymphocytic infiltrate, consistent with Hansen's disease borderline tuberculoid type, with features suggesting type 1 lepra reaction [Figures 3-6].
Granuloma surrounded by lymphocytes and epithelioid giant cells (H and E, x100)
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F6
Histopathological examination showed dermal edema, diffuse granulomas composed of Langhans type giant cells, surrounded by epithelioid cells, lymphocytes, multinucleated giant cells, and fibroblasts with perivascular lymphocytic infiltrate, consistent with Hansen's disease borderline tuberculoid type, with features suggesting type 1 lepra reaction [Figures 3-6].