PMC5036401_01
(a): Section showing oral mucosa and submucosa filled with dense infiltrate comprising inflammatory cells and sheets of large, polygonal cells. (b): Cells have moderate eosinophilic cytoplasm and reniform nuclei exhibiting grooves.
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F1
Extensive sampling of this area revealed an ill-defined nodular lesion beneath the epithelium composed of sheets of large, polygonal cells with moderate eosinophilic cytoplasm and reniform nuclei exhibiting grooves (Figure 1 (Fig. 1)).
Immunohistochemical staining showing (a) LCA reactivity, (b) S100 reactivity, (c) CD1a reactivity in the large cells. . (d) IHC staining for EMA is negative in these cells.
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F2
S100, CD68 and negative for LCA, EMA, cytokeratin (Figure 2 (Fig. 2)).