PMC5014552_01
A) Macroscopic tumour: an 8 cm tumour with a myometrial infiltration of more than 50%, reaching the uterine serosa B) H-E 20x: Solid tumoural nests are observed, consisting of small cells with limited cytoplasm.
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figure1
At macroscopy an 8 cm tumour, with a myometrial infiltration of more than 50%, reaching the uterine serosa was observed (Figure 1-A). At microscopy with haematoxilin and eosine, lymphovascular embolisation and parametrial stromal infiltration were observed (Figure 1-B).
A) Neoplastic nest, consisting of small cells with cytoplasmic positivity to chromogranin A. B) : Tumour cells with cytoplasmic positivity to synaptophysin.
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figure2
Immunohistochemistry analysis showed synaptophysin++; CD56 +; chromogranin A+ in isolated cells; Ki-67, 80% (Figure 2).
A) Peritoneal implants, consisting of small cells and IHQ pattern very similar to neuroendocrine primary tumour. B) Lymph nodes metastasis from serous carcinoma with synaptophysin (-) and chromogranin A (-).
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figure3
The pathological diagnosis of the peritoneal implants showed metastasis of neuroendocrine tumour, with similar features at immunohistochemical (IHQ) as previously described (Figure 3-A). However, high-grade serous carcinoma with synaptophisin (-) and chromogranin A (-) was diagnosed in 5 out of 13 pelvic lymph nodes and in 20 out of 25 para-aortic lymph nodes (Figure 3-B).