PMC8058177_01
Upper panel: time course of colchicine concentration (points: observed and line: modeled concentrations), in relation with the administration of activated charcoal, renal replacement therapy (CRRT), and extracorporeal membrane oxygenation (ECMO). Lower panel: time course of total bilirubin concentration (points) and of modeled colchicine clearance (line).
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F1
She received granulocyte colony-stimulating factor (G-CSF) from day 4 to 6, causing rebound leukocytosis from day 8 onwards (maximum 48.3 G/l on day 10) (Supplementary Figure 1). We followed colchicine blood levels (n = 25) until clear clinical improvement (Figure 1).