PMC2905718_01
Nodular lesions located on the upper lip.
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A 62-year-old Caucasian man presented a 2-month history of firm nodular lesions on the upper lip (Figure 1).
(a) Histopathology revealed a diffuse, monomorphous, nonepidermotropic infiltrate of large epithelioid cells throughout the entire dermis. (stain type:Hematoxylin and eosin; original magnification: x100). (b) Histopathology revealed a diffuse, monomorphous, nonepidermotropic infiltrate of large epithelioid cells throughout the entire dermis. (stain type:Hematoxylin and eosin; original magnification: x400).
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These cells were mixed with lymphocytes, plasma cells, and eosinophils (Figures 2(a) and 2(b)).
Immunohistochemical examination showed positivity for CD1a (a), CD68 (b), and S100 protein (c).
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Immunohistochemical examination revealed that the predominant cells coexpressed CD1a (Figure 3(a)), CD68 markers (Figure 3(b)), and S100 protein (Figure 3(c)).
Regression of the lesions after 7 months of treatment with thalidomide.
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Almost complete remission of the lesions was observed by the seventh month (Figure 4).