PMC6652043_01
(a), (b), (c). Deep dermal and mainly subcutaneous sarcoidal granulomata characterized by multinodular infiltrate of mono- and multinucleated epithelioid histiocytes with some lymphocytes (hematoxylin-eosin stain, magnifications 10 X, 10X, 20X, respectively).
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fig1
A skin biopsy was performed that revealed sarcoidal-type granulomatous inflammation in the dermis and subcutaneous tissue (Figures 1(a), 1(b), and 1(c)).
PMC6652043_02
(a), (b). Papulonodular lesions within the black tattoos in patient 2.
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fig2
The red, yellow, and green tattoos were completely uninvolved (Figures 2(a) and 2(b)).
(a), (b). Sarcoidal-type granulomatous inflammation confined to the areas harboring black tattoo pigment (hematoxylin-eosin stain, magnifications 10 X, 20X, respectively).
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fig3
In his 4-week follow-up visit, due to the lack of significant clinical improvement, a punch biopsy from the left upper arm was performed that revealed sarcoidal-type granulomatous inflammation, associated with only the black tattoo areas (Figures 3(a) and 3(b)).