PMC3434468_01
Clinical Overview: A - (smaller increase) tumor appearance, color of mucosa, slow and exophytic growing, sessile deployment,
smooth and well delineated surface. B - major increase.
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F1
It also had a smooth surface and a well-defined boundary (Fig. 1).
Axial CT scan showing a nodular image with sharp boundaries in part, measuring approximately 2.0x1.0 cm. A - CT soft tissue
window. B - CT hard tissue window.
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F2
The coronal CT scan with soft tissue and hard tissue window revealed a nodular area with soft tissue density, limits partially clear, measuring 2x2x1cm (Fig. 2).
Excisional biopsy: A - wedge incision. B - removal of debris. C - suture. D - surgical specimen.
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F3
Then this new specimen was sent for histopathological and immunohistochemistry analysis to confirm the histogenetic origin of the lesion (Fig. 3).
HE, 200x: ductal formations showing inner layer of cuboidal cells and also proliferation of solidly arranged polygonal cells.
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F4
It also revealed proliferation of polygonal cells arranged in a solid way (Fig. 4).
PMC3434468_02
Immunohistochemistry, 200x - Protein positivity for AE1/AE3 proteins in the inner cuboidal cells of the ductal formations.
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F5
The immunohistochemical evaluation was positive for antibodies AE1/AE3, S-100, p63 and Ki-67 in about 25% of neoplastic cells, resulting in a profile consistent with an epithelial-myoepithelial carcinoma with high-grade transformation (Fig. 5, 6, 7 and 8).
Immunohistochemistry, 200x - Diffuse staining for S100 protein in tumor cells.
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F6
The immunohistochemical evaluation was positive for antibodies AE1/AE3, S-100, p63 and Ki-67 in about 25% of neoplastic cells, resulting in a profile consistent with an epithelial-myoepithelial carcinoma with high-grade transformation (Fig. 5, 6, 7 and 8).
Immunohistochemistry, 200x - Nuclear staining for p-63 protein.
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F7
The immunohistochemical evaluation was positive for antibodies AE1/AE3, S-100, p63 and Ki-67 in about 25% of neoplastic cells, resulting in a profile consistent with an epithelial-myoepithelial carcinoma with high-grade transformation (Fig. 5, 6, 7 and 8).
Immunohistochemistry, 200x - Intense nuclear staining for Ki67 protein in several tumor cells.
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F8
The immunohistochemical evaluation was positive for antibodies AE1/AE3, S-100, p63 and Ki-67 in about 25% of neoplastic cells, resulting in a profile consistent with an epithelial-myoepithelial carcinoma with high-grade transformation (Fig. 5, 6, 7 and 8).