PMC3658253_01
Solid tumor nests with syringoid morphology showing an infiltrating pattern with angulated profile of epithelial islands.. Note: A desmoplastic stromal reaction is seen on the right side (hematoxylin and eosin, 4x).
imcrj-5-045Fig1.jpg
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f1-imcrj-5-045
Histopathological examination showed the presence of a differentiated cutaneous adnexal carcinoma, with syringoid and microcystic morphology, ulcerated and infiltrating subcutaneous tissue with perineural invasion, and a desmoplastic stromal reaction (Figures 1-3).
Basaloid cells forming tubular and tadpole-shaped structures (hematoxylin and eosin, 20x).
imcrj-5-045Fig2.jpg
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f2-imcrj-5-045
Histopathological examination showed the presence of a differentiated cutaneous adnexal carcinoma, with syringoid and microcystic morphology, ulcerated and infiltrating subcutaneous tissue with perineural invasion, and a desmoplastic stromal reaction (Figures 1-3).
Anaplastic nuclei with prominent nucleoli and mitosis in cancer cells (hematoxylin and eosin, 60x).
imcrj-5-045Fig3.jpg
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f3-imcrj-5-045
Histopathological examination showed the presence of a differentiated cutaneous adnexal carcinoma, with syringoid and microcystic morphology, ulcerated and infiltrating subcutaneous tissue with perineural invasion, and a desmoplastic stromal reaction (Figures 1-3).
Carcinoembryonic antigen immunohistochemical staining in tumor cells (avidin-biotin method, 20x).
imcrj-5-045Fig4.jpg
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On immunohistochemical staining, the tumor cells expressed carcinoembryonic antigen (Figure 4), cytokeratin (Pan), cytokeratin 7, and p63 protein (Figure 5), and were found to be negative for S100 protein, estrogen, and progesterone receptors.
p63 immunohistochemical staining in nuclear tumor cells (avidin-biotin method, 60x).
imcrj-5-045Fig5.jpg
PMC3658253_01_imcrj-5-045Fig5.jpg
f5-imcrj-5-045
On immunohistochemical staining, the tumor cells expressed carcinoembryonic antigen (Figure 4), cytokeratin (Pan), cytokeratin 7, and p63 protein (Figure 5), and were found to be negative for S100 protein, estrogen, and progesterone receptors.