PMC7139128_01
(Obtained with permission): Deep subcutaneous, non-erythematous and mobile nodules of the arm, the wrist and the hand (arrows).
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On examination, the patient presented inspiratory crackles in the basis of the two pulmonary chest fields and multiple deep subcutaneous, firm, non-tender, non-erythematous and mobile nodules, of 1-5 cm in size (Fig. 1).
Biopsy of a subcutaneous nodule of the arm: multiple confluent epithelioid and giganto-cellular granulomas in the adipose subcutaneous tissue surrounded by a discrete cuff of lymphocytes without any necrosis (arrow).. a/H&E staining. Magnification: x40.. b/H&E staining. Magnification: x200.
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Giant Langhans cells contained small asteroid or calcified bodies (Fig. 2).
Thoracic CT scan (parenchymal window): proximal peribronchovascular thickening associated to peribronchovascular, centrolobular and perilobular nodules (arrows).
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