PMC8478361_01
Gross view of the tumor showing multiloculated solid-cystic mass filled with blood.
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The gross appearance of the tumor revealed a multiloculated solid-cystic mass filled with blood (Figure 1).
Photomicrograph of the tumor. A - Epithelial component, ductal carcinoma in situ with comedonecrosis and cribriform pattern (H&E, x100); B - Malignant stromal component in vague fascicles of spindle cells (H&E, x100); C - Tumor cells with marked nuclear pleomorphism and atypical mitotic figures (H&E, x400); D - Malignant ovoid to spindle shaped cells (H&E, x400).
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Many bony trabeculae were identified with surrounding osteoblastic rimming (Figure 2 and 3).
Photomicrograph of the tumor. A - Metaplastic breast carcinoma with abundant osteoid formation (H&E, x100); B - High power view showing osseous differentiation (H&E, x400); C - Vague fascicles of spindle cells with numerous tumor giant cells (H&E, x100); D - Numerous osteoclastic giant cells interspersed with malignant cells (H&E, x400).
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Many bony trabeculae were identified with surrounding osteoblastic rimming (Figure 2 and 3).
Photomicrograph of the tumor. A - CK Epithelial component showing diffuse membranous and cytoplasmic immunoreactivity for cytokeratin (IHC, x400); B - Ki67 proliferation index around 8-10% (IHC, x400); C - p63 positive in mesenchymal component (IHC, x100); D - CD31 highlighting the proliferating vessels between tumor cells (IHC, x100).
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CD31 was negative in the tumor cells (Figure 4).