PMC9122666_01
Inflammation indicators obtained in the patient during hospitalization.
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Following hospitalization, routine blood tests revealed a total white blood cell count of 10.84x10^9/L, reduced neutrophil percentage (35.4%), an increased lymphocyte percentage (57.2%), a lymphocyte count of 6.20x10^9/L, a monocyte count of 0.69x10^9/L, a CRP of 1.54 mg/ L and PCT: 0.1 ng/ mL (Figure 1).
mNGS results of the patient. mNGS detected 12 HIV sequences in cerebrospinal fluid (A). The coverage and proportion of HIV detected by mNGS in cerebrospinal fluid (B). The blue ch2 and red ch1 lines denote the internal reference and specimen curve, respectively. mNGS, metagenomic next-generation sequencing.
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On the 4th day, the mNGS report confirmed the presence of 12 human immunodeficiency virus type 1 (HIV-1) sequences (Figure 2), but no other pathogenic microorganisms (including bacteria, viruses, mycobacteria, fungi, and parasites, among others) were detected.
qPCR results of the patient. qPCR results in HIV in cerebrospinal fluid (A) and blood (B). qPCR, quantitative polymerase chain reaction.
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HIV RNA qPCR 910 copies/mL, and blood HIV RNA qPCR 1.37x10^5 copies/mL (Figure 3). HIV antigen/antibody tests, performed between the 5th and 10th days, again showed negative results (the fourth generation), whereas a positive result was obtained on the 17th day.