PMC3361081_01
Pedigree of the family. The proband is indicated by an arrow. Left or right filled symbols indicate heterozygous carriers of LCAT (black) and apoB (gray) variants; white symbols indicate noncarrier relatives (square, male; circle, female). Slashed symbols indicate deceased individuals; N/A indicates family members not available for analysis.
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The proband (subject II.5, Fig. 1), a 53-year-old white man from northern Italy, was referred to our lipid clinic for severe hypoalphalipoproteinemia (HDL cholesterol below the 5th percentile for the general population) during an epidemiological study on the dialytic population of an Italian Region in 2008. The proband's pedigree spans three generations and includes 14 living subjects (Fig. 1).