PMC10041991_01
Chest CT scan at admission (A-C) and 2 months after antituberculosis therapy (D-F).
IDR-16-1669-g0001.jpg
PMC10041991_01_IDR-16-1669-g0001.jpg
f0001
CSF examination showed a prominent elevated protein level (2155 mg/dl; normal: 15-45 mg/dl) and a low glucose level (0.85 mmol/L; normal: 2.22-3.89 mmol/L). Chest CT showed nodules with calcification on the upper right lung, and consolidations in both lower lobes (Figure 1 A, B&C). CT scan showed a remissive state of ventriculomegaly, meningeal enhancement, and hydrocephalus (Figure 2E-H). Chest CT showed that his lung lesions improved (Figure 1D-F).
Brain MRI and CT scan at admission (A-D) and 2 months after antituberculosis therapy (E-H).
IDR-16-1669-g0002.jpg
PMC10041991_01_IDR-16-1669-g0002.jpg
f0002
Magnetic resonance imaging (MRI) showed ventriculomegaly, meningeal enhancement and hydrocephalus (Figure 2A-D). CT scan showed a remissive state of ventriculomegaly, meningeal enhancement, and hydrocephalus (Figure 2E-H). Chest CT showed that his lung lesions improved (Figure 1D-F).
Long-tunneled external ventricular drain.
IDR-16-1669-g0003.jpg
PMC10041991_01_IDR-16-1669-g0003.jpg
f0003
The patient underwent an emergency surgery of long-tunneled external ventricular drain (LTEVD) and Ommaya reservoir implantation under general anesthesia to relieve elevated intracranial pressure (Figure 3).
Concentration of various antituberculosis agents in the plasma and cerebrospinal fluid across time.
IDR-16-1669-g0004.jpg
PMC10041991_01_IDR-16-1669-g0004.jpg
f0004
Pharmacokinetics of antituberculosis drugs in the plasma and CSF is shown in Figure 4.
Timeline of major clinical events.
IDR-16-1669-g0005.jpg
PMC10041991_01_IDR-16-1669-g0005.jpg
f0005
The timeline depicting major clinical events is shown in Figure 5. Throughout the whole anti-TB treatment phase, we monitored his hepatic function regularly and it turned out normal.