PMC3271982_01
Mammography of the left breast, showing a 1.1 x 2.2-cm, well-demarcated, oval, isodense mass that was partly indistinct (arrow).
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F1
Mammography showed a 22-mm, well-demarcated, oval, isodense mass that was partly indistinct (BI-RADS category 4) (Figure 1), and ultrasonography revealed a 20 x 15 x 8.8-mm, well-demarcated, hypoechoic lesion with slightly irregular margins in the outer part of the left breast (Figure 2).
Ultrasonography of the breast shows a 20 x 15 x 8.8-mm, well-demarcated, low-echoic lesion with slightly irregular margins (arrow).
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F2
Mammography showed a 22-mm, well-demarcated, oval, isodense mass that was partly indistinct (BI-RADS category 4) (Figure 1), and ultrasonography revealed a 20 x 15 x 8.8-mm, well-demarcated, hypoechoic lesion with slightly irregular margins in the outer part of the left breast (Figure 2).
a) MRI of the left breast, showing a well-circumscribed mass with a high signal intensity on T2WI. b) On contrast-enhanced T1WI, the left breast lesion appeared as an enhanced mass with a microlobulated margin. c-f) The lesion on dynamic contrast MRI shows a peak in signal intensity within 90 seconds, after contrast injection.
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F3
MRI displayed a well-circumscribed mass with high signal intensity on T2-weighted images (T2WI) (Figure 3a). On contrast-enhanced T1-weighted images (T1WI), the mass showed strong enhancement with a microlobulated margin (Figure 3b). The signal intensity peaked within 90 seconds after the intravenous injection of the contrast medium gadolinium (Figure 3c-f).
Gross pathologic appearance of the myoid hamartoma. The cut surface of the lesion shows a yellow-white, well-circumscribed, non-encapsulated mass, resembling a fibroadenoma.
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F4
Macroscopically, the mass was completely excised and the cut surface of the lesion showed a yellow-white, well-circumscribed, non-encapsulated mass, resembling a fibroadenoma (Figure 4).
Hematoxylin and eosin and immunohistochemical staining of the breast tumor specimen. a) Hematoxylin and eosin staining of the breast tumor specimen shows a delicately encapsulated mass comprising fibrous and adipose tissue (Original magnification x 50). b-d) Immunohistochemical staining for smooth muscle actin, desmin, and HHF35 shows the smooth muscle histogenesis of stromal spindle cells (Original magnification x 150).
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F5
Microscopically, Hematoxylin and eosin staining showed benign ductal and lobular units, adipose tissue, fibrous stroma and bundles of elongated spindle cells in a disorganized pattern (Figure 5a). Immunohistochemically, the smooth muscle tissue stained diffusely positive for smooth-muscle actin (SMA), vimentin, desmin, and HHF35 (Figure 5b-d).