PMC10203157_01
Cutaneous manifestations of SAPHO syndrome (A-D). (A,B) Palmoplantar pustulosis was observed on the hands and feet, pre-operatively. (C,D) Palmoplantar pustulosis on the hands and feet disappeared during the follow-up period.
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Palmoplantar pustulosis was observed on the hands and feet (Figures 1A, B). Interestingly, the palmoplantar pustulosis on the hands and feet disappeared (Figures 1C, D).
Osteoarticular manifestations of SAPHO syndrome (A-K). (A,B) Plain radiographs revealed heterogeneous density of thoracic vertebrae and osteophytes at the edges of thoracic vertebrae. (C,D) Thoracic CT scanning demonstrated cortical erosion, osteophyte, and osteosclerosis of thoracic vertebrae. (E-I) Thoracic MRI showed thoracic vertebrae with vertebral lesions. (J) Sacroiliac joint CT revealed unsmooth joint surface, extensive sclerosis of the bone and patchy low-density shadow. (K) Whole-body bone scintigraphy demonstrated multifocal osteoarthritic lesions.
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Plain radiographs revealed heterogeneous density of some thoracic vertebrae and osteophytes at the edges of some thoracic vertebrae (Figures 2A, B). Thoracic computed tomography (CT) scanning demonstrated cortical erosion, osteophyte, and osteosclerosis of some thoracic vertebrae (Figures 2C, D). Thoracic magnetic resonance imaging (MRI) showed that low signal on T1-weighted images, high signal on T2-weighted images, and high signal on short time of inversion recovery (STIR) images of thoracic vertebrae with vertebral lesions (Figures 2E-I). Sacroiliac joint CT revealed unsmooth joint surface, extensive sclerosis of the bone and patchy low-density shadow (Figure 2J). Multifocal osteoarthritic lesions were found on whole-body bone scintigraphy (WBBS) (Figure 2K).
The pathological result showed lymphocyte infiltration.
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The pathological result demonstrated that lymphocyte infiltration (Figure 3).
Post-operative radiographic images (A-C). (A-C) Post-operative thoracic CT revealed that the bone cement in T8 and T9 vertebrae was well dispersed.
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T8 and T9 vertebrae was well dispersed (Figures 4A-C). The patient's back pain was significantly relieved, post-operatively.