PMC6051099_01
Cyclic thrombocytopenia in relation to cycles of ixazomib indicated by orange arrows (I1-I5) and the onset of DTMA indicated by green arrow.
CRIHEM2018-7063145.001.jpg
PMC6051099_01_CRIHEM2018-7063145.001.jpg
fig1
After the second cycle of ixazomib, the patient had been having intermittent GI disturbances including diarrhea, and biweekly blood test revealed thrombocytopenia with a nadir of about 75000/dl (Figure 1), which were both attributed to ixazomib.