PMC3265251_01
(a) The pretherapy anterior (0  degree) maximum intensity projection image of the PET/CT study of patient 1 showing multiple metastatic lesions in bilateral supraclavicular fossa, throughout the mediastinum, hila and in abdominal nodal basins. (b) The six-months posttherapy anterior (0  degree) maximum intensity projection image of the PET/CT study of the patient showing complete resolution of the previously seen FDG avid lesions.
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fig1
Imaging with PET/CT showed very extensive disease that appeared to primarily involve nodal areas (Figure 1(a)). CT (without PET) done after three cycles showed complete resolution of all radiographic lesions and a subsequent PET/CT after three more cycles also showed complete resolution of FDG uptake (Figure 1(b)).
PMC3265251_02
(a) The pretherapy anterior (0  degree) maximum intensity projection image of the PET/CT study of the patient demonstrating multiple pleural-based nodular metastatic lesions in the left chest along with prominent FDG uptake also seen in the activated brown fat tissue in multiple locations. (b) The six-months posttherapy anterior (0  degree) maximum intensity projection image of the PET/CT study of the patient showing complete resolution of the previously seen FDG avid lesions associated with intense bone marrow FDG activity and increased splenic activity seen due to therapy-induced bone marrow stimulation.
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fig2
A chest CT indicated prominent pleural-based densities and pleural thickening in the left hemithorax with a PET/CT scan showing an area of intense hypermetabolism in the left pleural compartment (Figure 2(a)). After the first three cycles, a follow-up PET/CT scan indicated significant shrinkage of multifocal lobular-nodular based metastases in the lung with complete resolution of FDG uptake (Figure 2(b)).
PMC3265251_03
(a) The pretherapy anterior (0  degree) maximum intensity projection image of the PET/CT study of the patient is shown with the red arrows indicating the right internal iliac and left common iliac lesions. (b) The four-months posttherapy anterior (0  degree) maximum intensity projection image of the PET/CT study shows resolution of previously seen FDG avid bilateral iliac lesions while the arrow indicates the FDG activity at left antecubital fossa injection site.
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fig3
Although she had complete resolution of her primary and inguinal disease, follow-up CT imaging showed development of a soft tissue mass in the pelvis deep to the right psoas muscle, also involving the iliac arteries, with progression of the disease indicated on further imaging (Figure 3(a)). After two additional cycles, there was further reduction in tumor size and complete resolution of FDG uptake per PET/CT (Figure 3(b)).