PMC3936143_01
Ductal adenocarcinoma. Complex papillary cribriform architectural patterns within the prostatic ducts (A, B). Mucosa of the prostatic urethra seen to the left (A), (H&E, low-power magnification, x4).
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The specimens contained an approximately 1.4 cm focus of ductal adenocarcinoma with Gleason score 7(3+4), which was located near the intraprostatic urethra (Figures 1 and 2).
Ductal adenocarcinoma with papillary patterns in the prostatic ducts (H&E, medium-power magnification, x10).
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The specimens contained an approximately 1.4 cm focus of ductal adenocarcinoma with Gleason score 7(3+4), which was located near the intraprostatic urethra (Figures 1 and 2).
Immunostaining: A. CKHMW immunoreactivity (34betaE12 antibody). Negative in ductal adenocarcinoma structures, positive in urethral urothelium (low-power magnification, x4). B. Positive prostate-specific antigen (PSA) immunoreactivity in ductal adenocarcinoma cells (medium-power magnification, x10). C. Positive PSAP (prostate-specific acid phosphatase) immunoreactivity in ductal adenocarcinoma cells (medium-power magnification, x10)
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In the immunohistochemical examination these cancer cells were PSA and PSAP positive, whereas CKHMW negative (Figure 3).