PMC5499499_01
Neuroradiological follow-up: a) iodine contrast-enhanced computed tomography axial image obtained in 2016, March, at relapse; b) and c) gadolinium-enhanced T1-weighted magnetic resonance axial images obtained after the 2nd and the 6th cycle, respectively.
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The patient was defined ineligible for radiotherapy (RT) because of age, wide vasogenic edema and high risk of neurotoxicity and started intramuscular dexamethasone 8mg daily and oral temozolomide 250mg daily for 5 consecutive days without any improvement after 1st cycle; total body CT scan (Figure 1A) showed a further increase of the right frontal mass (diameter 7cm) without other disease localizations. We decided to continue this association; Gadolinium-enhanced brain MRI (Figure 1B) was performed after the 2nd cycle and showed a wide reduction of neoplastic tissue (diameter 37 mm), vasogenic edema, and mass effect. Gadolinium-enhanced brain MRI (Figure 1C) showed disease progression.