PMC4880434_01
The histopathological photomicrography of the tumor. A - Solid lesion composed by sheets of uniform cells. Small blood vessels are uniformly distributed within the tumor but may not be apparent (H&E, 2X); B - Solid glomus tumor showing monomorphic round cells with eosinophilic cytoplasm and central punched-out nuclei. (H&E, 40X).
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No ulceration, nor vascular and/or perineural invasion (Figure 1A) was found. The vascular structures showed positivity with CD34. Therefore, the histopathology confirmed the diagnosis of glomus tumor of the stomach (Figure 1B).
Photomicrography of the tumor. A - Negative reaction for CD117 (40X); B - Positive reaction for actin (40X).
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In the gastrointestinal tract, CD117 is a highly specific marker of gastrointestinal stromal tumors; it is not expressed by tumors in the differential diagnosis of a glomus tumor (Figure 2A). These glomus cells may show intense positivity for actin antibodies (Figure 2B).