PMC4697037_01
A - The biopsy specimen from the duodenum taken during the first hospitalisation in the Children's Memorial Heath Institute. Duodenal villi are normally formed with the absence of inflammation, the number of IELs is significantly increased, varying from 30 up to 50 lymphocytes per 100 enterocytes. Original magnification 20x. B - Increased number of IEL stained with anti-CD3 antibody (red colour) are visible in the duodenal specimen. Original magnification 40x
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F0001
Although duodenal villi were normally formed with the absence of inflammation (Figure 1 A), the number of IEL was increased, varying from 30 up to 50 lymphocytes per 100 enterocytes (Figure 1 B).
The biopsy specimen from the bulb duodenum taken during the second hospitalisation. Flattened villi and significantly increased IEL number characteristic of active CD are shown. Original magnification 20x
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F0002
Either in duodenal bulb or in other parts of the duodenum flattened villi with significantly increased number of IEL (50 lymphocytes per 100 enterocytes) and moderate polymorphic infiltrates in the lamina propria were observed (Figure 2).
PMC4697037_02