PMC6077322_01
CT scan showed soft-tissue density neoplasms filling with sphenoidal sinus.
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Computed tomography (CT) scanning revealed soft-tissue density neoplasms filling the sphenoidal sinus (Figure 1).
Sagittal T1-weighted magnetic resonance image (MRI) and coronary T2-weighted MRI revealed a mass occupying the sphenoidal sinus (a,b). Gadolinium-enhanced MRI demonstrated the neoplasm with homogenous soft-tissue lesion occupying the sphenoidal sinus and destroying the clivus (c,d).
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fig2
Magnetic resonance imaging (MRI) scanning with gadolinium injection was performed and revealed a homogeneous mass lesion (2.8cm x 2.3cm x 2.9cm) occupying the sphenoidal sinus and invading and destroying the clivus (Figure 2).
Pathological photomicrographs demonstrated that the mucosa was intact and expanded by a diffuse infiltrate of lymphoma cells (a, H&E). The mucosal lymphoid infiltrate was destructive, resulting in necrosis. The medium-to-large transformed cell nuclei had an irregular nuclear folding with granular appearance (b, H&E). Positive immunohistochemical staining was recorded for (c) CD56, (d) CD3, (e) LCA, (f) CD38, and (g) EBER in situ hybridization (original magnification: x200).
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The immunohistochemical staining of tumor tissues showed CD3+, CD56+, Ki67>80%, LCA+, CD38+, and CD20- (Figure 3).
Bone marrow smear and biopsy showed active hyperplasia, immature lymphocytes accounting for 3% of heterotypic large cells with scattered distribution.
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Bone marrow smear and biopsy showed active hyperplasia, immature lymphocytes accounting for 3%, and heterotypic large cells having a scattered distribution (Figure 4).