PMC5726698_01
Firm, erythematous nodule, adhered and with central crust, measuring 2.0
x 1.5cm, located on the left nasojugal groove
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f1
On dermatological examination, there was a firm, erythematous nodule, measuring 2.0 x 1.5 cm, adhered to the skin, with a central crust and located on the left nasojugal groove (Figure 1).
Spindle cell neoplasia (*) diffusely infiltrating the dermis and
epidermis (arrow) (Hematoxylin & eosin, X200)
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f2
An incisional biopsy was performed, and the histology revealed a poorly differentiated malignancy, with a spindle cell pattern, diffusely infiltrating the dermis (Figures 2 and 3).
Detail of spindle cell with bulky, elongated, cigar-shaped nuclei
(Hematoxylin & eosin, X400)
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f3
An incisional biopsy was performed, and the histology revealed a poorly differentiated malignancy, with a spindle cell pattern, diffusely infiltrating the dermis (Figures 2 and 3).
Positive staining for HUC-1 (A) and desmin (B) (X200)
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f4
Immunohistochemistry was positive for specific muscle actin (HHF-35), smooth muscle actin (HUC-1) and Ki-67 in 10% of the tumor cells (Figure 4).