PMC7204348_01
(a) Intraoral photograph: a painful necrotic ulcer in the right maxillary gingiva. (b) Horizontal FDG-PET/CT: pathological uptake of FDG at the bilateral lung.
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The perilesional premolar showed mild mobility with occlusal and percussion pain (Figure 1(a)). Fluorodeoxyglucose-positron emission tomography/CT (FDG-PET/CT) indicated the presence of increased uptake in the right maxilla (maximum standardized uptake value: SUVmax = 5.85) and bilateral lungs (S8 of the inferior lobe of the right lung SUVmax = 4.94) but no uptake in the right submandibular lymph node (Figure 1(b)).
Histopathology results. The histopathological diagnosis was EBV-positive diffuse large B-cell lymphoma (DLBCL). (a) H&E stain (x40) showed large numbers of lymphocytes accumulation in the submucosal stroma. (b) H&E stain (x200): lymphocytes accumulation was atypical and large sized with a background of inflammatory cell infiltration. Immunohistochemistry stain (x200): tumor cells showed strong positivity for CD20 (c) and EBER-ISH (d).
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The result of EBV-encoded small RNA in situ hybridization (EBER-ISH) was positive, and the histopathological diagnosis was EBV-positive diffuse large B-cell lymphoma (DLBCL) (Figure 2).