PMC6304607_01
Nests and cribriform structures of variable size and shape, separated by moderate amount of fibrotic dense stroma (H&E; 50x).
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fig1
Microscopically, the neoplasm is composed of cohesive, uniform, cuboidal cells with minimal cytoplasm, arranged in nests and cribriform structures of variable size and shape, separated by moderate amount of fibrotic dense stroma (Figure 1).
Cohesive cuboidal cells with minimal amount of cytoplasm, round uniform nuclei with regular contour, finely granular chromatin, no nucleoli, and no mitotic activity (H&E; 200x).
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Mitotic figures are absent to extremely rare (2 per 10 HPF) (Figure 2).
Synaptophysin immunohistochemical stain (cytoplasmic staining) (200x).
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fig3
Tumor cells stained positive with cytokeratin (clones AE1/AE3), synaptophysin (Figure 3), chromogranin A (Figure 4), EMA, and CDX-2 (Figure 5) but negative for CD99, TTF-1, CK7, CK20, and CEA.
Chromogranin A immunohistochemical stain (cytoplasmic staining) (200x).
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fig4
Tumor cells stained positive with cytokeratin (clones AE1/AE3), synaptophysin (Figure 3), chromogranin A (Figure 4), EMA, and CDX-2 (Figure 5) but negative for CD99, TTF-1, CK7, CK20, and CEA.
CDX2 immunohistochemical stain (nuclear staining) (200x).
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fig5
Tumor cells stained positive with cytokeratin (clones AE1/AE3), synaptophysin (Figure 3), chromogranin A (Figure 4), EMA, and CDX-2 (Figure 5) but negative for CD99, TTF-1, CK7, CK20, and CEA.