PMC5015789_01
Computed tomography showing a retrobulbar orbital mass in the left orbit (black arrow)
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F1
A CT scan showed enhancement of the retrobulbar optic nerve of the left eye with an adjacent, discrete soft tissue enhancement bordering the posterior globe (Figure 1 (Fig. 1)).
Magnetic resonance imaging showing a retrobulbar orbital mass in the left orbit
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F2
Two weeks later, an MRI showed diffuse thickening and contrast enhancement involving the retrobulbar portion of the left optic nerve associated with a surrounding soft tissue lesion within the intraconal orbital fat, and the lesion seemed to be extending more posteriorly than the previous CT image (Figure 2 (Fig. 2)).
H&E section of the tumor shows a diffuse growth pattern of large, dysplastic lymphocytes with vesicular nuclei (A), which are positive for CD10 (B) and CD20 immunostain (C). The Ki67 (D) immunostain demonstrates a high (>90% of tumor cells) proliferative index.
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F3
Histology of the mass showed tissue diffusely infiltrated with large, dysplastic lymphocytes with vesicular nuclei (Figure 3A (Fig. 3)). Immunohistochemical stains showed that the lymphoid cells were positive for CD10 and CD20 (Figure 3B and 3C (Fig. 3)) and were negative for CD3 and keratin AE1/AE3. Ki-67 demonstrated proliferative activity in greater than 90% of tumor cells (Figure 3D (Fig. 3)).