PMC8328690_01
Diagnostic biopsy in case 1 (a) staining with hematoxylin and eosin; the epithelial origin is confirmed by the positivity to high MW cytokeratin (b); the proliferative index, evaluated with the MIB-1 clone of the Ki-67 antibody, highlights the malignant nature of the lesion with high proliferation (c).
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fig1
A nodular, hard, nonstenotic lesion was detected at cystoscopy on the site of previous BMG implantation (bulbar urethra) and biopsied, showing poorly differentiated SCC (Figure 1).
Representative sections of the surgical specimen of case 1 (surgical biopsy of bulbar urethra). Well-differentiated squamous cell carcinoma with a horn-like appearance of pearls (full arrow) and surface erosion (empty arrow). The lesion invades the dermis and muscle tissue (staining with hematoxylin and eosin).
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fig2
Histology confirmed poorly differentiated SCC pT2N2 in the bulbar urethra (Figure 2).
PMC8328690_02
Representative sections of the surgical specimen of case 2 (hematoxylin and eosin staining): surgical resection specimen of the buccal patch (a; original magnification x50); keratinized epithelium on the right side of the image on the left side lies the infiltrating carcinoma (inset: detail at higher magnification of squamous nature consisting in keratin pearl). Aggregates and nests of intensely eosinophilic neoplastic cells with densely, hyperchromatic nuclei and keratinizing features are widely identified all over the specimen, confirming the carcinoma's squamous nature (b; original magnification x100).
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fig3
Histology showed poorly differentiated SCC of the urethra, diffusely infiltrating the corpora cavernosa (Figure 3).