PMC7753187_01
Axial, sagittal, and coronal slices from MRI and [18F] fluorodeoxyglucose ([18F]FDG), [18F]PI2620, and [18F]AV45 PET scans. (A-C) T1-weighted sequences in MRI show cortical and subcortical atrophy, especially in bilateral parietal and occipital lobes. (D-F) [18F]FDG PET revealed significant hypometabolism in diffuse regions of bilateral temporal, parietal, and occipital lobes, prominently in occipital lobes, and no metabolic change was observed in the frontal lobes, basal ganglia, and thalami. (G-I) [18F]PI2620 PET showed increased tracer uptake throughout the brain, especially in the temporal, parietal, and occipital lobes. (J-L) [18F]AV45 PET showed amyloid deposition throughout the cortex that was especially pronounced in bilateral frontal cortices.
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F1
Brain MRI showed marked diffuse cortical and subcortical atrophy in bilateral parietal and occipital lobes. [18F]FDG PET revealed significant hypometabolism in diffuse regions of bilateral temporal, parietal, and occipital lobes, prominently in occipital lobes, and no metabolic changes were observed in frontal lobes, basal ganglia, and thalami; [18F]PI2620 PET showed increased tracer uptake throughout the brain, especially in temporal, parietal, and occipital lobes, while standardized uptake value ratios (SUVRs) were 3.8, 4.0, and 4.3, respectively, using cerebellum as the reference region, in close correspondence with the regions that showed the most prominent hypometabolism; [18F]AV45 PET was positive with amyloid deposited throughout the cortices (Figure 1).