PMC9037860_01
Photomicrograph of the tumor. A, B, C - Lobules of tumor cells with abundant vacuolated cytoplasm, surrounded by more basophilic tumor cells in the periphery of the lobules (HE); D - Clusters of cells without evidence of sebaceous differentiation, indistinguishable from a classic ductal carcinoma (HE).
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Histopathological examination revealed breast sebaceous carcinoma of Bloom and Richardson grade III type (nuclear grade 3, histologic grade 3, mitotic grade 3) (Figure 1).
Photomicrograph of the tumor. Immunohistochemical panel. A - Positive expression of EMA in the tumor cells (100 x); B - Positive expression of GATA-3 in the tumor cells (25 x); C - Strongly positive expression of CD15 in the tumor cells with sebaceous differentiation (100 x); D - Focal positivity of GCDFP15 in the tumor Cells (25X)
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The immunohistochemical panel revealed positivity for EMA (Figure 2A), GATA3 (Figure 2B), AE1AE3, CK7, CD15 (Figure 2C), GCDFP15 (focal staining) (Figure 2D), PMS2, MLH1, MSH2, MSH6, and negativity for P63, Melan-A, HMB45, 1A4, estrogen receptor (ER), progesterone receptor (RP), mammaglobin, calponin, and HER2 (+1).
PMC9037860_02