PMC7475754_01
Representative photomicrograph of angiodysplasia of the gallbladder. Low-power magnification shows reduced and wide mucosal folds with cylindrical epithelia of the mucosa almost entirely missing. There was a moderate mixed inflammatory cell infiltrate in the submucosa, and the muscular layer was slightly hypertrophic, which is consistent with chronic cholecystitis. An interesting finding was large, dilated, and malformed arteries and veins in the distorted muscular layer extending into the submucosa and mucosa. (HE; 40x). The inset microphotograph shows a large thick artery from the submucosa of the wall of the gallbladder body (HE; 200x).
CRIPA2020-7192634.001.jpg
PMC7475754_01_CRIPA2020-7192634.001.jpg
fig1
The most unusual feature of the slide from the body of the gallbladder was the presence of large dilated vessels within the muscular layer extending into the submucosa and mucosa (Figure 1).
Immunohistochemistry of angiodysplasia. The endothelial lining was confirmed immunohistochemically with positive staining for CD31 and CD34 (not shown), while staining for podoplanin (D2-40) monoclonal antibody was negative (inset microphotograph) (immunohistochemistry; 100x).
CRIPA2020-7192634.002.jpg
PMC7475754_01_CRIPA2020-7192634.002.jpg
fig2
The appearance of angiodysplasia of the gallbladder and its endothelial lining was confirmed immunohistochemically using CD34, CD31, and podoplanin (D2-40) monoclonal antibodies (Figure 2).