PMC3997246_01
Histologic features of adenomyoepithelioma. The large lobulated neoplasm is located in the dermis and surrounded by a fibrous pseudocapsule (A). Beneath an intact epidermis a superficial zone of fibrosis (B) is present. The neoplasm is composed of tubular and ductal structures as well as solid-appearing tumor areas set in a fibromyxoid stroma (C). [Copyright:  2012 Riedl et al.]
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Each of the aggregates of neoplastic cells varied in sizes and shapes and some were large and nodular (Figure 1A-C).
Cutaneous adenomyoepithelioma is made up of different cellular components. In foci glandular and ductal structures are present; occasionally apocrine-type secretion within glandular structures is found (A-C). In other areas myoepithelial cells with clear cytoplasm predominate (D-F). In various areas cells are present within a myxoid stroma (G-H). Within solid cell aggregation pleomorphic cells and mitotic figures are evident (K-L). [Copyright:  2012 Riedl et al.]
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At higher magnification, most of the cells that constituted the lesion displayed myoepithelial differentiation with polygonal and "plasmacytoid" features (Figure 2). In places glandular and ductal structures were evident; in some areas apocrine-type secretion within glandular structures was found (Figure 2 A-C). Focally, the myoepithelial cells contained a clear cytoplasm (Figure 2 D-F). In some areas cells were present within a myxoid stroma (Figure 2 G-H). Foci of cells with pleomorphic nuclei and mitotic figures were identified (Figure 2 K-L).