PMC8337042_01
The trend of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin from time of admission to postdischarge follow-up.
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PMC8337042_01_ac9-8-e00518-g001.jpg
F1
With serial blood work, his total bilirubin continued to rise with a peak of 0.735 mmol/L while the liver enzymes continued to improve (Figure 1).
PMC8337042_02
The liver biopsy revealed centrilobular cholestasis with yellow-green bile in hepatocytes and canaliculi (rhodanine stain, 400x magnification). Inset: histopathology of canalicular bile plug (hematoxylin and eosin stain, 400x magnification).
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PMC8337042_02_ac9-8-e00518-g002.jpg
F2
There was moderate to severe cholestasis consistent with drug-induced cholestatic liver injury (Figure 2).