PMC6477498_01
Well-defined lesion on the right buttock.
cde-0011-0048-g01.jpg
PMC6477498_01_cde-0011-0048-g01.jpg
F1
On examination, there was a 0.8 x 0.7-cm well-defined, brown nodule on the right buttock (Fig. 1).
Nests of basaloid cells with peripheral palisading and surrounding cleft were attached to seborrheic keratosis. H&E staining. x40.
cde-0011-0048-g02.jpg
PMC6477498_01_cde-0011-0048-g02.jpg
F2
Nests of basaloid cells with peripheral palisading and surrounding cleft were attached to the lesion of seborrheic keratosis (Fig. 2).
Basal cell carcinoma was selectively positively stained with Ber-EP4. Immunostaining. x40.
cde-0011-0048-g03.jpg
PMC6477498_01_cde-0011-0048-g03.jpg
F3
In an immunochemical study, strong positive staining for Ber-EP4, a useful marker of basal cell carcinoma, was found in the basal cell carcinoma area, but not in the seborrheic keratosis area (Fig. 3).