PMC4010022_01
Zones of hepatocyte necrosis surrounded by hemorrhage without significant inflammation. (100x magnification; Hematoxylin-Phloxine-Saffron (HPS) stain.)
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fig1
Liver histology revealed diffuse acute liver necrosis with few inflammatory changes (Figure 1).
Viral inclusions are readily visible in infected hepatocytes. (600x magnification; Hematoxylin-Phloxine-Saffron (HPS) stain.)
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fig2
Multiple viral inclusion bodies with the characteristic clear halo distinctive of Cowdry type A inclusions were seen in her hepatocytes (Figure 2).
Immunohistochemistry for HSV virus highlights viral inclusions (600x magnification).
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fig3
Immunostaining was positive for HSV antibodies (Figure 3).