PMC8349032_01
Chest radiograph on admission, showing left lower lobe consolidation (A, C). Chest radiograph on day 15, showing improvement in bilateral consolidation (B, D).
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Chest radiography showed left lower lobe consolidation, suggesting acute pneumonia (Fig. 1A). Chest CT showed bilateral dorsal infiltration (Fig. 1C). Follow-up chest radiography and chest CT demonstrated improvement of left lower lobe consolidation (Fig. 1B, D).
Result of the histologic analysis of the bone marrow aspirate. (A) (original magnification x 200). Bone marrow smear showing decreased myeloid precursors and increased erythroid islands with normal morphology. (B, C) (original magnification x 400). Sample stained with hematoxylin and eosin showing normocellular marrow.
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Bone marrow (BM) aspiration revealed a decreased proportion of myeloid precursor cells and increased proportion of erythroid precursor cells and megakaryocytes, without any evidence of hematological disorders, such as acute leukemia, myelodysplastic syndrome, and aplastic anemia (Fig. 2).
A timeline illustrating the absolute neutrophil count since the beginning of atezolizumab-related toxicity. TAZ/PIPC: tazobactam/piperacillin; LVFX: levofloxacin; G-CSF: granulocyte colony-stimulating factor.
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On the 10th day, his neutrophil count recovered to over 500/mm3 (Fig. 3), and both antibiotic therapy and G-CSF therapy were discontinued.