PMC8429964_01
Diffuse bilateral perihilar inhomogenous infiltrates on chest X-ray.
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C-reactive protein (CRP) 296.4 mg/dl and slite elevation of gamma-glutamyl transferase (GGT) 80 mg/dl and lactate dehydrogenase (LDH) 315 mg/dl. Chest X-ray showed diffuse bilateral perihilar nonhomogeneous infiltrates (Fig. 1).
(A and B) High-resolution computed tomography scan of the chest showing diffuse interlobar septal thickening with ground-glass opacities.
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Further investigation included a high-resolution computed tomography (HRCT) scan of the chest that showed diffuse interlobar septal thickening with the extensive ground-glass opacities in the upper lungs and consolidation in the anterior segment of the right upper lobe (Figure 2. (A and B)).
Lung tissue showing organizing pneumonia, interstitial thickening and hyaline membranes (H&E stain, 100X).
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The intra-alveolar foamy macrophages with cytoplasmic vacuolization were characteristic of amiodarone lung toxicity (Fig. 3, Fig. 4, Fig. 5.) One week after patient's clinical condition improved and he was discharged from the hospital.
Small aggregates of lipid-laden macrophages in alveolar spaces. Also note aforementioned morphologic changes (H&E stain, 400X).
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The intra-alveolar foamy macrophages with cytoplasmic vacuolization were characteristic of amiodarone lung toxicity (Fig. 3, Fig. 4, Fig. 5.) One week after patient's clinical condition improved and he was discharged from the hospital.