PMC4168687_01
Conceptual methodology for determination of dose. Theoretical 7-step compartmentalization of decision workflow (left column) and implementation considerations specific to this case study of a 10 year-old child with hemiparesis due to perinatal stroke (right column). Incorporation of prior experience in the dose decision process coupled with modeling allows value-determination of subject-specific dose decisions for implementation.
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F1
This involves integration of prior clinical trials and modeling; (1) with the subject specific information, desired clinical outcome, constraints and current flow criterion (Figure 1).