PMC7719769_01
Brain CT on admission (panels 1-2) shows sequellar macro calcification of former neurotoxoplasmosis episodes (red arrows). Panels (3-6) refer to brain CT with angiography (venous phase); thrombosis of superior sagittal and right transverse sinus. Brain MRI realized 6 months before admission (a-f) and on admission (A-F). White matter hyperintensities in T2 FLAIR account for CSF HIV escape related progressive neuroinflammation. Absence of lesions in the posterior fossa.
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F1
Brain magnetic resonance imaging (MRI) showed a venous sinus thrombosis (superior sagittal and lateral; confirmed by (computed tomography) CT angiogram in venous phase) as well as periventricular and intra-parenchymatous white matter hyper-intensities in T2-FLAIR as compared to brain MRI realized on June 2019 (Figure 1).
Evolution of CSF and serum HIV viral load and CNS inflammation markers under treatment. Patient was admitted in our hospital on 13th of December 2019. << T-1 >> accounts for 26th of November 2019, << T0 >> for 13th of December 2019, << T1 >> for 10th of February 2020 and << T2 >> for 14th of April 2020.
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F2
Decrease in both CSF and serum viral load as well as CSF inflammatory markers were found (Figure 2).