PMC9531772_01
Imaging findings and rash features in patients with FPIES. Scattered echoes of gas in the anterior right lobe [(A) white arrow], diffuse bowel wall thickening (with a thickness of 3.3 mm) [(B), coarse arrow] and scattered echoes of gas in parts of the intestinal wall [(B), white arrow] were detected using ultrasound in case 1. Numerous red exudative papules fused and distributed all over the body, including the face, were observed in case 2 (C). Both the upper and lower eyelids were red and swollen with little ulceration (C). The rash in case 2 improved gradually after avoiding milk ingestion (D). Urticaria was distributed all over the body in case 3 (E). Distended loops of intestine were seen in X-ray in case 4 [(F), black arrow)].
fped-10-913278-g001.jpg
PMC9531772_04_fped-10-913278-g001.jpg
F1
An X-ray suggested intestinal distention (Figure 1F). In the outpatient follow-up, the regular formula was introduced again when the baby was 1 month old, and watery stools and intermittent vomiting appeared within 24 h (Timeline and summary of case series are shown in Figure 2 and Table 1).
PMC9531772_02
Imaging findings and rash features in patients with FPIES. Scattered echoes of gas in the anterior right lobe [(A) white arrow], diffuse bowel wall thickening (with a thickness of 3.3 mm) [(B), coarse arrow] and scattered echoes of gas in parts of the intestinal wall [(B), white arrow] were detected using ultrasound in case 1. Numerous red exudative papules fused and distributed all over the body, including the face, were observed in case 2 (C). Both the upper and lower eyelids were red and swollen with little ulceration (C). The rash in case 2 improved gradually after avoiding milk ingestion (D). Urticaria was distributed all over the body in case 3 (E). Distended loops of intestine were seen in X-ray in case 4 [(F), black arrow)].
fped-10-913278-g001.jpg
PMC9531772_04_fped-10-913278-g001.jpg
F1
An X-ray suggested intestinal distention (Figure 1F). In the outpatient follow-up, the regular formula was introduced again when the baby was 1 month old, and watery stools and intermittent vomiting appeared within 24 h (Timeline and summary of case series are shown in Figure 2 and Table 1).
PMC9531772_03
Imaging findings and rash features in patients with FPIES. Scattered echoes of gas in the anterior right lobe [(A) white arrow], diffuse bowel wall thickening (with a thickness of 3.3 mm) [(B), coarse arrow] and scattered echoes of gas in parts of the intestinal wall [(B), white arrow] were detected using ultrasound in case 1. Numerous red exudative papules fused and distributed all over the body, including the face, were observed in case 2 (C). Both the upper and lower eyelids were red and swollen with little ulceration (C). The rash in case 2 improved gradually after avoiding milk ingestion (D). Urticaria was distributed all over the body in case 3 (E). Distended loops of intestine were seen in X-ray in case 4 [(F), black arrow)].
fped-10-913278-g001.jpg
PMC9531772_04_fped-10-913278-g001.jpg
F1
An X-ray suggested intestinal distention (Figure 1F). In the outpatient follow-up, the regular formula was introduced again when the baby was 1 month old, and watery stools and intermittent vomiting appeared within 24 h (Timeline and summary of case series are shown in Figure 2 and Table 1).
PMC9531772_04
Imaging findings and rash features in patients with FPIES. Scattered echoes of gas in the anterior right lobe [(A) white arrow], diffuse bowel wall thickening (with a thickness of 3.3 mm) [(B), coarse arrow] and scattered echoes of gas in parts of the intestinal wall [(B), white arrow] were detected using ultrasound in case 1. Numerous red exudative papules fused and distributed all over the body, including the face, were observed in case 2 (C). Both the upper and lower eyelids were red and swollen with little ulceration (C). The rash in case 2 improved gradually after avoiding milk ingestion (D). Urticaria was distributed all over the body in case 3 (E). Distended loops of intestine were seen in X-ray in case 4 [(F), black arrow)].
fped-10-913278-g001.jpg
PMC9531772_04_fped-10-913278-g001.jpg
F1
An X-ray suggested intestinal distention (Figure 1F). In the outpatient follow-up, the regular formula was introduced again when the baby was 1 month old, and watery stools and intermittent vomiting appeared within 24 h (Timeline and summary of case series are shown in Figure 2 and Table 1).
Timeline of symptom development, serum-specific antibodies tests, dietary changes and other laboratory findings in the cases. AAF, amino acid-based formula; CRP, C-reactive protein; IL-6, interleukin-6; IL-8, interleukin-8; TNF-alpha, tumor necrosis factor-alpha; EEG, electroencephalogram; ESR, erythrocyte sedimentation rate; eHF, extensively hydrolyzed formula.
fped-10-913278-g002.jpg
PMC9531772_04_fped-10-913278-g002.jpg
F2
In the outpatient follow-up, the regular formula was introduced again when the baby was 1 month old, and watery stools and intermittent vomiting appeared within 24 h (Timeline and summary of case series are shown in Figure 2 and Table 1).