PMC3518093_01
Bone metastasis in the sternoclavicular joint invading adjacent soft tissues.
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fig1
The thoracoabdominal CT scan revealed an osteolytic sternoclavicular joint mass (Figure 1) and 3 liver metastases.
Partial response after radiotherapy and 10 months of imatinib with partial reossification in the sternoclavicular joint and decreasing of the soft tissue extension.
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fig2
Control contrast-enhanced CT scans showed a partial response in bone lesion (Figure 2) as well as in liver metastases.
Bone scintigraphy image showing increasing intensity of tracer uptake localized in the sternoclavicular joint.
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fig3
Bone scintigraphy showed an increasing intensity of tracer uptake localized in the sternoclavicular joint (Figure 3).
Bone marrow biopsy: Spindle cells with high cellularity. Some of the tumor cells show mild pleomorphism. Numerous mitotic figures are present ( ) (hematoxylin and eosin: x400).
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fig4
The histological features and staining pattern of the tumor cells were consistent with a GIST metastasis (Figures 4 and 5).
Positive immunostaining with c-Kit (CD117). Note diffuse membranous pattern (HE x400).
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fig5
Immunohistochemical staining demonstrated the tumor cells to be positive for c-kit (CD117) (Figure 5) protein and CD34 protein. The histological features and staining pattern of the tumor cells were consistent with a GIST metastasis (Figures 4 and 5).