PMC7187677_01
Lymph node in the first relapse (x 400). Sheet-like growth of medium-to-large atypical cells with irregular nuclear
shapes was observed (a, HE). On immunohistochemistry, the
lymphoma cells were CD3-positive (b), CD4-positive
(c), CD10-focally positive (d),
CD20-negative (e), PD1-focally positive
(i), EBER-negative (j), BCL6-positive
(k) and CXCL13-positive (l).
Proliferation of follicular dendritic cells (FDC) was noted on
immunohistochemistry with CD21 (f). Hodgkin-Reed
Sternberg-like B-cells were positive for CD30 (g) and PAX-5
(h).
jslrt-60-26-g001.jpg
PMC7187677_01_jslrt-60-26-g001.jpg
f1
LNs. Left cervical LN biopsy yielded the diagnosis of nodal peripheral T-cell lymphoma with follicular helper T-cell phenotype (nodal PTCL with TFH phenotype) (Figure 1).