PMC8077455_01
Neoplasm before PDT. Exophytic neoplasm of 4 x 6 cm with atypical vessels and contact bleeds.
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F1
Knife biopsy of the cervix was performed on 6 and 9 hours (shown in Fig. 1).
Acetic test before PDT. Intensive acetowhite epithelium on the surface. Horizontal stitch on the lower pole after knife biopsy.
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F2
The exophytic neoplasm had intensive acetowhite epithelium in the test with 5% acetic acid (shown in Fig. 2).
8-Bit image of the cervix with acetic test. Yellow border is the cervix surface with tumor and acetic test. Red color is an area of acetowhite epithelium.
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F3
The digital visualization showed a highly intensive and large square of pathological tissues on the cervical surface area (shown in Fig. 3).
First stage. Cervical canal irradiation.
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F4
The light was delivered by the cylindrical diffuser in the cervical canal (shown in Fig. 4).
Second stage. Cervical surface irradiation.
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F5
The cervical surface was irradiated by a macro-lens with a multi-location technique (shown in Fig. 5).
1 min after PDT. No coagulation necrosis indicators. The cervix surface looks blue with grey-white tin.
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F6
A grey-white tin formed in a healthy area (shown in Fig. 6).
7 days after PDT. Tumor in the resorption process. Apoptotic and necrotic masses.
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F7
These conditions are caused by apoptosis and necrosis in the tumor area (shown in Fig. 7).
Acetic test. 27 days after PDT. Erosion area around cervical cancer. Acetowhite epithelium line around erosion area.
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F8
The epithelialization phase started 1 month after the PDT session (shown in Fig. 8).
1 min after PDT. Singlet oxygen hyperoxidation. Cyanotic tissues and microthrombosis. Apoptosis was induced.
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F9
Dynamic changes in squamous cell epithelium for 1 month are shown in Figures 9, 10, 11. The cervical surface was cyanotic after 1 min of the PDT session (shown in Fig. 9).
7 days after PDT. Alteration phase. Cervix surface with apoptotic and necrotic masses.
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F10
Dynamic changes in squamous cell epithelium for 1 month are shown in Figures 9, 10, 11. There were necrotic and apoptotic masses on the cervical surface (shown in Fig. 10) and the left vagina sidewall (shown in Fig. 11).
7 days after PDT. Alteration phase. Left vagina sidewall with apoptotic and necrotic masses.
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F11
Dynamic changes in squamous cell epithelium for 1 month are shown in Figures 9, 10, 11.
Acetic test. 35 days after PDT. Endometrioid heterotopias around the cervical canal. Epithelialization process. Left vagina sidewall with PS.
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F12
Fig. 12). Fluorescence diagnostics were used to control the efficacy of previous procedures.
Fluorescence diagnostics. 35 days after PDT. Pathological tissues fluorescence with accumulating PS.
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F13
PS accumulation (shown in Fig. 13). Pathological fluorescence showed inflammation of tissues.
1 min after PDT. Cervix surface. Cyanosis area. Microthrombosis.
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F14
Dynamic changes in squamous cell epithelium for 7 days are shown in Figures 14, 15, 16. Reaction of the tissues of the cervix and left vagina sidewall after PDT is shown in Figures 14 and 15.
1 min after PDT. Left vagina sidewall. Cyanosis area. Microthrombosis.
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F15
Dynamic changes in squamous cell epithelium for 7 days are shown in Figures 14, 15, 16. Reaction of the tissues of the cervix and left vagina sidewall after PDT is shown in Figures 14 and 15.