PMC7339073_01
A 55-year-old man with nodules of Kaposi sarcoma (KS) in the skin of the medial aspect
of the right thigh. Purple, raised skin nodules (arrows) are present in the skin of the
inner aspect of the right thigh, consistent with Kaposi sarcoma (KS).
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Examination of the skin showed a cluster of dark nodular lesions on his medial right thigh and purple plaques of varying size below the knees (Figures 1 and 2).
A 55-year-old man with purple, raised nodules of Kaposi sarcoma (KS) in the skin of the
right lower extremity.
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Examination of the skin showed a cluster of dark nodular lesions on his medial right thigh and purple plaques of varying size below the knees (Figures 1 and 2).
A 55-year-old man with violaceous areas of Kaposi sarcoma (KS) in the mucosa of the
soft palate (arrow).
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A violaceous lesion was found on examination of the soft palate (Figure 3).
Photomicrographs of the histology and immunohistochemistry of Kaposi sarcoma (KS) in
the soft palate biopsy showing: (a) low power view of nodular skin lesion with atypical
spindle cell proliferation (H&E, 40x), (b) atypical spindle cell proliferation with
extravasation (100x), and (c) positive immunostaining with an antibody to human
herpesvirus-8 (HHV-8)-positive for spindle cells (100x).
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Histopathology showed spindle cells forming slit-like spaces, some of which contained red blood cells (Figure 4(a) and (b)), which supported the diagnosis of KS and excluded some of the possible differential diagnoses, including bacillary angiomatosis, benign hemangioma, and angiosarcoma. Routine diagnostic immunohistochemistry confirmed the presence of HHV-8 (Figure 4(c)), and there was positive immunostaining of the spindle cell populations for the endothelial cell marker CD34.