PMC8794752_01
Radiological findings. (A) High-resolution computed tomography (HRCT) findings on admission showing bronchial wall thickening and centrilobular nodules in the lower lobe of both lungs. (B) At recurrence, HRCT showed radiological findings similar to those seen on admission. (C) After the addition of benralizumab, bronchial wall thickening and centrilobular nodules improved.
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F1
HRCT findings showed bronchial wall thickening and centrilobular nodules in the lower lobes of both lungs (Figure 1A). HRCT showed bronchial wall thickening and centrilobular nodules, as seen during diagnosis (Figure 1B), suggesting recurrence of the disease. Radiological findings of bronchial wall thickening and centrilobular nodules also attenuated (Figure 1C).
Immunostaining findings of the mucus plug on bronchoscopy. (A) An obstructive mucus plug is present in the bronchial lumen of B1+2c of the left upper lobe. (B) Hematoxylin and eosin staining of the mucus plug section showing a multilayered structure, with the accumulation of many chromatolytic eosinophils. (C) Formation of galectin-10-positive Charcot-Leyden crystals (green) and net-like DNA (blue) can be observed near intensive staining of the major basic protein (red). Identical section to B was immunostained.
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F2
Bronchoscopy showed obstruction of the subsegmental bronchus with mucus plugs (Figure 2A). Hematoxylin and eosin staining of the mucus plug section showed a multilayered structure with accumulation of many chromatolytic eosinophils (Figure 2B). Galectin-10-positive Charcot-Leyden crystals (CLCs) were formed near the MBP-deposited area with net-like DNA (Figure 2C).