PMC6535824_01
Patient's serum sodium levels and antidepressant treatment regimen during hospitalization. Following discontinuation of agomelatine and duloxetine on the 6th and 7th day of hospitalization the patient's serum sodium level rose from 127 to 135 mmol/L. Ultimately, the patient's depression was well managed with mirtazapine and aripiprazole with tapering of escitalopram.
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As a consequence, the duloxetine was discontinued and he was initiated on a high-salt diet, leading to resolution of his hyponatremia (serum sodium: 135 mmol/L) and symptoms including unsteady gait, dizziness, nausea, general malaise, and poor appetite within 8 days (Figure 1).