PMC3958928_01
A) Scanning magnification view of the wedge-shaped lesion showing a deep dermal melanocytic proliferation (2.5x). (B) Tumor infiltrating lymphocytes are seen between large melanocytes with prominent nucleoli (20x). (C) A focus suggestive of tumor necrosis is present (40x).
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F1
Microscopic sections showed a slightly wedge-shaped lesion with a dermal component of oval melanocytes with abundant cytoplasm and hyperchromatic nuclei and with an overlying ill-defined lentiginous epidermal component (Fig. 1).
A) High power view of lymph node deposit shows cytologically atypical pigmented tumor cells that are similar to the original lesion, with (B) corresponding HMB45 immunostain positivity. (C and D). Other intraparenchymal deposits are also HMB45-positive.
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F3
The tumor cells were enlarged with abundant pigment and with moderately large, irregular nuclei and conspicuous nucleoli (Fig. 3).