PMC10185901_01
Axial enhanced CT scan showing the poorly delimited right renal mass at diagnosis.
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Subsequent CT scans showed a heterogeneous 50 x 47 x 45 mm parenchymal renal mass involving the renal sinus ( Figure 1 ), along with lymph node involvement in para-aortic and inter-aortocaval locations.
Histological features of the radical nephrectomy of the right kidney. (A) SMARCB1-deficient renal medullary carcinoma (hematoxylin-eosin-saffron, x15 magnification): tumor cells are pleomorphic with enlarged nuclei, vesicular chromatin, proeminent nucleoli, and eosinophilic cytoplasm. (B) Immunohistochemistry (SMARCB1, x15 magnification) shows loss of expression of SMARB1 (also known as INI1, SNF5, or BAF47) within the tumor cells, whereas intratumoral lymphocytes are strongly positive (nuclear stain).
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Histologic features are shown in  Figure 2 .
A timeline depicting patient care with the main notable events during follow-up. The timeline is represented by a green stripe divided into years. The black triangle indicates the date of diagnosis; the yellow star denotes the timing of renal mass biopsy; the red stars indicate the timing of surgeries; the blue arrows denote the timing of recurrence and death; and the violet stripes represent periods of chemotherapy.
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A timeline depicting patient care is shown in  Figure 3 .