PMC9675176_01
Hypothetical natural history of maternal infection for the case study. Results of serological and molecular markers are included. Infection might have started at some point between the end of the first trimester of pregnancy and the beginning of the second. After vertical transmission, intrauterine manifestations appeared, with the first clinical marker being inadequate contractions for the gestational age. At consultation foetal anaemia and generalized hydrops were observed with the final outcome of foetal death by the end of the second trimester of gestation. At this stage, the assay to determine specific IgM turned out negative, while levels of IgG were increasing and viral DNA remained detectable. WG: weeks of gestation.
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