PMC6082924_01
The percentage of totally and partially CD59-deficient red blood cells in patients 1-6 [(A-F), respectively]. For patients 1, 3, 5, and 6 who had intravascular hemolysis, the lactate dehydrogenase levels (LD) are shown at right on the Y-axis as values in relation to the upper limit of normal (A,C,E,F). Patients 1 and 2 (A,B) suffered from leukemia and subsequently died. Patients 3-6 are in remission.
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F1
In later controls, the expression has been either fully normal or the CD59-negative erythrocyte cell clone has been small (between 0.2 and 1.4%) (Figure 1D). The PNH clone has been declining (Figure 1E). In 2010, the size of the PNH clone had already clearly diminished, and in 2013, it was 0.3% in RBCs and 0.8% in neutrophils (Figure 1F). For all six patients, the median CD59-deficient RBC clone size was 64% at highest (range 30-91%) (Figure 1).