PMC9482418_01
Head MRI results of the patient. (1)-(6) was on admission, and (7)-(9) was 1 month later. (1) and (2) Patchy long T1 signal and slightly longer T2 signal in the right frontal, temporal, and insular lobes; (3)-(5) High signals in Flair and DWI lesion areas, and slightly higher signal in ADC area; (6) Patchy enhanced shadows in some lesion areas, and the dura mater adjacent to these lesion areas was enhanced and thickened; (7)-(9) Patchy long T1 and T2 signals in the right frontal, temporal pole, and insular lobes, local atrophic, necrotic, and softening foci, and widening of the right temporal horn.
j_biol-2022-0464-fig001.jpg
PMC9482418_01_j_biol-2022-0464-fig001.jpg
j_biol-2022-0464_fig_001
While on diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) sequences, high signals and patchy enhanced shadows in the lesion areas were also observed, and the dura mater adjacent to the lesion areas was enhanced and thickened (Figure 1). Local necrosis and softening foci were formed, and the right temporal horn was widened (Figure 1).
mNGS results of the patient. (a) The DNA reads positions and coverage of HHV-2 detected by mNGS. The coverage of HHV-2 detected by mNGS was 95.44%. (b) The content of detected microbes by mNGS. A total of 12,024 unique reads (87.09%) of HHV-2 were sequenced.
j_biol-2022-0464-fig002.jpg
PMC9482418_01_j_biol-2022-0464-fig002.jpg
j_biol-2022-0464_fig_002
On July 26th, the mNGS result came out, and a total of 12,024 unique sequences of HHV-2, with a coverage of 95.44% were detected (Table 1, Figure 2), indicating HHV-2 meningoencephalitis.