PMC2590677_01
PMC2590677_02
PMC2590677_03
CT and PET scans of EBV-related SMN of liver. CT scan of the abdomen and pelvis (8/05) from Patient 3 revealed multiple masses, mainly in the right lobe and involving segment 4. The largest mass measured 6.8 x 5.8 cm and was located in the right inferior lobe (a). FDG-PET (9/05) demonstrated areas of hypermetabolism in the inferior aspect of the right hepatic lobe (SUV max 5.7), and two other neighboring foci (SUV max 5) (b).
SRCM2008-859407.001.jpg
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fig1
Positron emission tomography (PET) scan (9/05) showed tracer uptake in the liver lesions (Figure 1).
Gross
and microscopic findings from EBV-related SMN of liver. Liver specimen from
Patient 3 measured 17 x 13.2 x 7.6 cm. Four nodules were found, ranging in size
from 0.4 cm to 6.7 cm (a). Histologic features on H&E staining included
moderate increased cellularity (with areas containing rounder, less fusiform
cells), lack of nuclear pleomorphism, and a low mitotic rate (1 mitotic
figure/50 high-powered field) (b). Nearly all cells were positive for
EBV-EBER by ISH, although intensity of the staining varied from cell to cell (c). Electron microscopy revealed spindle cells with abundant cytoplasmic
aggregates of actin microfilaments, including fusiform dense bodies and
attachment plaques, confirming the diagnosis of a well-differentiated smooth
muscle proliferation (d).
SRCM2008-859407.002.jpg
PMC2590677_03_SRCM2008-859407.002.jpg
fig2
SMNs (Figure 2). She remains without disease as of October 2008.