PMC9640422_01
The functional connection mode of the patient before and after treatment. (A) The left subplot shows the five imaging features using the package "pDoC." In the right subplots, the black circles represent the responding imaging measurements of the patient before treatment, and the cyan squares represent the measurements after treatment. The boxplot in each subplot represents the measurement of a group of normal controls. (B) EEG activity of patients in different periods. Images of brain amplitude, activity, and complexity before and after st-SCS treatment are presented separately. (C) Topographic map distribution and local change rate of PE in different periods. Topographic maps before and after st-SCS treatment are presented in the upper part. PE changes in the frontal, central, parietal and occipital are presented in the below column. (D) Recurrence plot of information interaction and brain interval change. The recurrence plot was shown in the upper part. The connectivity changes before and after treatment are compared between the frontal-central, frontal-parietal, and central-parietal brain regions below.
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F1
The electrode (3777, Medtronic, USA) was placed at the C2 level and fixed (Supplementary Figure S1). Functional connectivity between aMPFC in the DMN and DMPFC in the ECN was also changed significantly (Figure 1A). We also found brain activity, amplitude, and rhythm in EEG increased (Figure 1B), and the whole brain ordering entropy changes of patients were compared by the topographic map (Figure 1C). Finally, we found the channel information interaction increased after treatment (Figure 1D).