PMC9619915_01
(A) Section of lymph node with effaced architecture and deposition of pink,
amorphous material (H&E x100). (B) Immunostaining of the lymph node
highlighting AL amyloid (x400).. Abbreviations: AL amyloid, light chain amyloid; H&E,
hematoxylin-eosin.
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An ultrasound-guided core biopsy of the right axilla suggested an amyloid tumor of the breast associated with moderate lymphocytic infiltrate (Figure 1A). Congo red stains supported the diagnosis of amyloidosis, and presence of AL amyloid was confirmed by immunochemistry (Figure 1B).
Renal biopsy showing amyloidosis, extensively involving glomeruli, blood
vessels, and interstitium (H&E x400).. Abbreviation: H&E, hematoxylin-eosin.
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To evaluate proteinuria, a renal biopsy was performed, which showed amyloidosis of light chain-lambda type, extensively involving glomeruli, blood vessels, and interstitial tissues (Figure 2).