PMC9936763_01
Kidney biopsy in a patient with HIV with MN (a) with segmentally visible immune deposits and no proliferative features (arrows, Masson Trichrome. x200), granular predominantly peripheral capillary wall staining with near "full house" pattern with IgG (b), and C1q (c). d, e Electron microscopy shows segmentally distributed subepithelial as well as mesangial and rare small subendothelial immune deposits (transmission electron microscopy, direct magnification d. x2,800, e. x7,100). f Glomerular immune deposits are NELL1-positive by immunohistochemistry (x200).
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F1
Kidney biopsy (Fig. 1) demonstrated MN with segmental subepithelial eosinophilic immune deposits on the outer aspect of the glomerular capillary loops.
Spontaneous and sustained remission of proteinuria, with stable kidney function.
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F2
His proteinuria improved from 9 g to 6 g in 2 months' time and to less than 1 g at 7 months (Fig. 2).