PMC4719346_01
There were multiple bony prominence measuring 2 cm in diameter at the back from cervical to lumbar and posterior thoracic region (arrows), they made bony bridges from inferior occipital bone, cervical spine, extending to paravertebral lumbar region. (B) Slight valgus deformity of right great toe (arrow)
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F1
The shoulder, cervical, and thoracal spine ranges of movement were limited (Fig 1).
Radiograph of the cervical spine lateral view showed bone formation starting from occiput, cervical, and upper thoracic spine (arrows). (B) Chest and shoulder radiographs also showed bone formation at the bilateral humerus bridging to the tip of scapula (arrows). (C) CT reconstruction revealed multifocal ossification which supported radiographic finding, paravertebral bony bridge (arrow head), bony bridges from bilateral humerus to tip of scapula (arrows)
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F2
It was in accordance with myositis ossificans progresiva (Fig 2).
(A)Histopathology showed formation of endochondral ossification (arrow) (H&E, 100x). (B) Skeletal muscle and formation of endochondral ossification (arrow) (H&E, 100x). (C) Formation of endochondral ossification (arrow head), bone trabeculae and marrow (arrow) (H&E, 100x).
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F3
There was also endochondral ossification with no cellular atypia (Fig 3).
(A) Clinical picture 4 months after surgery, local recurrences were detected (arrow). (B) Cervical radiograph 4 months after surgery, there was local recurrence of bony bridge from occiput, cervical, and upper thoracic spine (arrow). (C) Thoracic radiograph 4 months after surgery, there was recurrence of bony bridge from bilateral humerus to the tip of scapula (arrow head).
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F4
Four months after surgery local recurrences were detected, which was confirmed with radiograph (Fig 4).