PMC5829335_01
CT chest showing a 5.6 cm x 4.9 cm lymph node mass in the right axilla.
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fig1
CT scan of the chest, abdomen, and pelvis performed showed lymphadenopathy in the axillary area (Figures 1 and 2), lymphadenopathy in the abdominal cavity, and splenomegaly of 14.8 cm (Figure 3).
CT chest showing a 0.7 cm lymph node in the left axilla.
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fig2
CT scan of the chest, abdomen, and pelvis performed showed lymphadenopathy in the axillary area (Figures 1 and 2), lymphadenopathy in the abdominal cavity, and splenomegaly of 14.8 cm (Figure 3).
CT abdomen showing splenic enlargement of 14.8 cm.
CRIHEM2018-9368451.003.jpg
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fig3
CT scan of the chest, abdomen, and pelvis performed showed lymphadenopathy in the axillary area (Figures 1 and 2), lymphadenopathy in the abdominal cavity, and splenomegaly of 14.8 cm (Figure 3).
High-power photomicrograph of a hematoxylin and eosin- (H/E-) stained histologic section showing effacement of the lymph node architecture by the proliferation of immunoblastic cells (arrows) with abundant amphophilic cytoplasm, eccentric round large nuclei, and prominent single macronucleoli. Scattered apoptotic bodies and tangible body macrophages (arrowheads) were seen in background (original magnification: x400).
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fig4
Microscopic examination of the histologic section showed diffuse effacement of the lymph node tissue architecture by the proliferation of immunoblastic cells with abundant amphophilic cytoplasm, eccentric round large nuclei, and prominent single macronucleoli (Figure 4).
Composite photomicrograph of immunohistochemical and in situ hybridization studies showing that tumor cells are positive for (a) CD138 (variable), (b) CD79a (weak, variable), (c) CD30, (d) MUM1, (e) EBV (EBER), and (f) HHV-8.
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fig5
Immunohistochemical studies (Figure 5) were performed with appropriate positive and negative controls according to established protocols.