PMC3617888_01
Case 1: erosive erythema around the labium minor and external urethral meatus before (a) and after (b) the administration of topical tacrolimus. Case 2: erythema around the labium minor with pitted purpura (c).
cde-0005-0079-g01.jpg
PMC3617888_02_cde-0005-0079-g01.jpg
F1
On her initial visit, physical examination revealed erythema around the labium minor with pitted purpura (fig. 1c).
Prominent cellular infiltrate in the superficial to mid dermis (a, b). The infiltrating cells were mainly composed of plasma cells and lymphocytes (c, d). Original magnification: x50 (a, b), x400 (c, d). Case 1: a, c; case 2: b, d.
cde-0005-0079-g02.jpg
PMC3617888_02_cde-0005-0079-g02.jpg
F2
A biopsy specimen revealed a prominent cellular infiltrate in the superficial to mid dermis (fig. 2c). The infiltrating cells were mainly composed of plasma cells and lymphocytes (fig. 2d).
Paraffin-embedded tissue samples from the patient were stained as follows: the sections were developed with new fuchsin for CD163 (a, b) and IL-17 (c, d). Original magnification: x50 (a, c), x200 (b, d).
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PMC3617888_01_cde-0005-0079-g03.jpg
F3
To analyze the pathogenesis of PLC, we performed immunohistochemical staining for CD163 and IL-17, which revealed the dense infiltration of CD163+ cells in the superficial to mid dermis (fig. 3a, b) and scattered IL-17-producing cells in the superficial to mid dermis (fig. 3c, d).
PMC3617888_02
Case 1: erosive erythema around the labium minor and external urethral meatus before (a) and after (b) the administration of topical tacrolimus. Case 2: erythema around the labium minor with pitted purpura (c).
cde-0005-0079-g01.jpg
PMC3617888_02_cde-0005-0079-g01.jpg
F1
On her initial visit, physical examination revealed erythema around the labium minor with pitted purpura (fig. 1c).
Prominent cellular infiltrate in the superficial to mid dermis (a, b). The infiltrating cells were mainly composed of plasma cells and lymphocytes (c, d). Original magnification: x50 (a, b), x400 (c, d). Case 1: a, c; case 2: b, d.
cde-0005-0079-g02.jpg
PMC3617888_02_cde-0005-0079-g02.jpg
F2
A biopsy specimen revealed a prominent cellular infiltrate in the superficial to mid dermis (fig. 2c). The infiltrating cells were mainly composed of plasma cells and lymphocytes (fig. 2d).