PMC5088446_01
Multimodal imaging findings of angioid streaks at baseline visit. Color (a) and red-free (RF) photographs (b) of the right eye show angioid streaks at the peripapillary region radiating into the fovea. Late-phase fluorescein angiogram (c; FA) shows variable staining of the angioid streaks with no leakage. Fundus autofluorescence (d; FAF) imaging shows areas of hypoautofluorescence in the peripapillary area that are greater in size than the corresponding AS seen on color photography. AS correlate to breaks within the Bruch's membrane (yellow arrow) as seen on spectral domain optical coherence tomography (e; SD-OCT). The yellow line indicates the location of the SD-OCT scan.
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Fig1
OD and 20/30 OS. On presentation, his right eye demonstrated AS on multimodal imaging (Fig. 1).
Multimodal imaging findings of choroidal neovascularization. Angioid streaks are observed on the red-free image (a); however, no hemorrhage is evident. Overlay of false-colored optical coherence tomography angiography (OCTA) over the color photograph (b) outlines the area of choroidal neovascularization (CNV). En Face OCTA (c) demonstrates two area of CNV (red and blue arrows) that demonstrate a tangled morphology of vascular networks. Sites of CNV closely correlate to sites of angioid streaks (d; arrowheads) when OCTA is compared to en face reflectance images. Structural OCT scans (I and II) confirm a mixed type 1 (I) and type 2 (II) neovascular lesion which arise in proximity to sites of Bruch's membrane disruption.
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Fig2
Multimodal imaging characteristics of this CNV are provided in Figs. 2 and 3.
Comparison between indocyanine green angiography and optical coherence tomographic angiography for visualizing type 1 neovascularization. Areas of type 1 NV (arrow) may be difficult to discern on ICGA (a) due to hyperfluorescent staining of angioid streaks (arrowheads) within areas of NV. In contrast, type 1 NV demonstrates a characteristic tangled morphology appearance on OCTA (b) that is easily appreciated. Inset on ICGA corresponds to the region of interest on OCTA image. Note the projection artifact of retinal vessels on the OCTA image.
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Fig3
Multimodal imaging characteristics of this CNV are provided in Figs. 2 and 3.