PMC8039716_01
Multiple nodular opacities are present bilaterally in lungs.
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PMC8039716_01_gr1.jpg
fig1
A repeat chest CT scan was obtained, which revealed nodular areas of consolidation in both lungs (Fig. 1).
Section A shows dense, monotonous population of centrocyte-like cells while part B demonstrates positivity for CD 21.
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fig2
Due to her apprehensions against general anesthesia, a CT-guided right lung biopsy was performed, which disclosed a dense, monotonous population of centrocyte-like cells (Fig. 2). Immunohistochemistry stained positive for CD20, Bcl-2, and CD21 while in situ hybridization (FISH) showed kappa light-chain restriction, which confirmed the diagnosis of a marginal zone lymphoma (MZL) (Fig. 2).
Section A shows mono-morphos small cell lymphoid infiltrate with slightly irregular nuclear contours and moderate pale cytoplasm (centrocyte-like morphology) infiltrating the lamina propria with focal infiltration of the epithelial structures while section B demonstrates CD20 diffusely positive in a monotonous population of B-cells.
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fig3
Gastric biopsies revealed an atypical B-cell lymphoid infiltrate consistent with an extra-nodal marginal zone lymphoma of MALT (Fig. 3).