PMC9293550_01
Electron micrograph showing subepithelial electron-dense deposits consistent with class 5 lupus nephritis and intracytoplasmic lamellated bodies (also known as curvilinear bodies-white arrows) within the overlying podocyte. Original magnification 1000x.
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fig1
In addition to these findings, electron microscopy showed that intracellular inclusions were found within many podocytes and some tubular epithelial cells (Figure 1).
PMC9293550_02
On the left (a), an electron micrograph of endomyocardial biopsy with myeloid bodies (single black arrows) is present including a "zebra" type in the upper part of the figure. Curvilinear bodies (white double arrows) are also present. On the right (b), higher magnification of curvilinear bodies.
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fig2
Myeloid bodies and curvilinear bodies were present on ultrastructural examination (Figure 2).
PMC9293550_03
On the left (a), an electron micrograph of skeletal muscle biopsy with Nemaline rod (black arrow). On the right (b), an electron micrograph of the myeloid body, black arrow and curvilinear bodies (white double arrows).
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fig3
A muscle biopsy (Figure 3) showed more than 50% lobulated myofibers, some with excessive mitochondrial activity, small numbers of myofibers with nemaline rods, lysosomal curvilinear bodies, and fiber type grouping, all consistent with chronic denervation and reinnervation.