PMC6252228_01
(a) Histologic sections showing a cellular proliferation of pleomorphic cells, some of which are multinucleated (H&E stain, 100x original magnification); lymphocytic infiltration is also seen (b); (c) neoplastic cells show eosinophilic cytoplasm and intracytoplasmic vacuoles, with mitotic figures identified (H&E stain, 400x original magnification); immunohistochemistry shows diffuse reactivity for S-100 (d), GFAP (e), and neurofilament (f); the Ki-67 proliferative index is moderately elevated (g).
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fig2
Some cells are multinucleated (Figure 2(a)). Lymphocytic infiltration is focally seen (Figure 2(b)). Neoplastic cells show prominent eosinophilic cytoplasm, with intracytoplasmic vacuoles (Figure 2(c)). On immunohistochemical assessment, there is diffuse reactivity for S-100 protein (Figure 2(d)) and GFAP (Figure 2(e)), supporting astrocytic origin. Immunoreactivity for neurofilament is also observed (Figure 2(f)). The Ki-67 proliferative index is moderately elevated (Figure 2(g)).