PMC3789302_01
Representative imaging of patient in Case 1. Left mammogram showing clustered calcification corresponding to multiple sites of disease in craniocaudal (a) and mediolateral-oblique (b) projections. MRI showing extensive nonmass enhancement in the lateral hemisphere of the left breast in segmental distribution (c).
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fig1
A magnetic resonance image (MRI) showed extensive abnormal nonmass enhancement in a segmental distribution corresponding to changes seen on her mammogram (Figures 1(a)-1(c)).
PMC3789302_02
PMC3789302_03
PMC3789302_04
Representative histology of all four cases. There is extensive DCIS with cribriform configuration (arrow). The multiple foci of invasion (arrowhead) occur in between the DCIS (magnification x100).
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fig2
Pathology of the insitu and invasive ductal carcinomas observed in all four cases shows striking similarity, and the representative histological figures are illustrated in Figure 2.