PMC6158312_01
MRI and histological examination. Preoperative MRI of the brain: (A,B) There are two T1 hypointense T2 hyperintense mass lesions in the left frontal lobe subcortical white matter and involving the cortex with heterogeneous enhancement measuring 3.2 x 3.1 and 4.5 x 3.3 cm, respectively. There is surrounding vasogenic edema and small areas of restricted diffusion. Microscopic examination of the left frontal lobe biopsy showed diffuse involvement of the brain parenchyma by Diffuse Large B-cell lymphoma: (C) H&E staining, (D) CD20+ B-cells, (E) CD3+ T-cells, and (F) Ki67 shows a markedly elevated proliferation index (>95%).
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F1
On MRI, there were two enhancing lesions in the left frontal lobe suggesting the possibility of metastatic CNS lymphoma (Figure 1).