PMC10299898_01
Brain CT and MRI. (A, B) Show significant calcification in the bilateral cortex, subcortex, and basal ganglia on computed tomography (CT). (C) Signal level is decreased in the white matter on diffusion-weighted images. (D) Signal level is increased in the white matter on fluid-attenuated inversion recovery imaging. (E) Signal level is decreased in the white matter of the frontal lobe on the T1-weighted image. (F) Gadolinium contrast-enhanced signal levels is increased in the white matter of the frontal lobe on the T1-weighted image.
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F1
Magnetic resonance imaging (MRI) showed increased fluid-attenuated inversion recovery signals in the white matter and increased gadolinium contrast-enhanced T1-weighted imaging (T1WI) signal in the white matter of the frontal lobe (Figure 1).
Brain MRI 1 year after the start of the therapy. (A) The signal level is decreased in the white matter of the frontal lobe on the T1-weighted image. (B) Gadolinium contrast-enhanced signal levels are still sustained compared to those 1 year ago in the white matter of the frontal lobe on the T1-weighted image.
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F2
T1WI signal was not spread; however, it was sustained (Figure 2).
Clinical course. The time course of the patient is shown.
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F3
These findings suggested that the obvious progression of her higher brain dysfunction was not detected, but the demyelination was sustained. The clinical course of the patient's disease is described in Figure 3.