PMC5828302_01
Abdominal CT scan showing an enlarged spleen with its visible rupture (1) and bleeding outside the capsule.
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fig1
The abdominal spiral computed tomography (CT) examination was performed that showed spleen enlargement with a nonhomogeneous polycyclic contrast-enhanced lesion and bleeding in the infiltrative lesion with slight bleeding outside the fibroelastic capsule of the organ (Figures 1 and 2).
Abdominal CT scan performed before the surgery. Significant spleen enlargement is visible with distinctive area of parenchyma affected by the angiosarcoma.
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fig2
The abdominal spiral computed tomography (CT) examination was performed that showed spleen enlargement with a nonhomogeneous polycyclic contrast-enhanced lesion and bleeding in the infiltrative lesion with slight bleeding outside the fibroelastic capsule of the organ (Figures 1 and 2).
Microscopic view of angiosarcoma with hemorrhagic areas and vascular channels lined by endothelial atypical cells (hematoxylin and eosin staining, 100x).
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fig3
Cytokeratin, CD117, and S100 protein immunohistostaining were negative (Figures 3-5).
Vascular capillaries of various sizes and cavernous-like spaces lined by endothelial cells with high-grade atypia (hematoxylin and eosin staining, 200x).
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fig4
Cytokeratin, CD117, and S100 protein immunohistostaining were negative (Figures 3-5).
Immunohistochemical stain for CD34 highlights the malignant endothelial cells (200x).
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fig5
Cytokeratin, CD117, and S100 protein immunohistostaining were negative (Figures 3-5).
The coronal scope (a) and axial scope (b) of radiotherapy plan and dose distribution illustrated by different isodoses.
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fig6
A dose of 45 Gy (fraction dose 1.8 Gy) was given to the tumor bed with additional boost to the area of larger curvature of the stomach to a total dose of 50.4 Gy due to the positive surgical margins (Figures 6(a) and 6(b)).