PMC8606967_01
Cutaneous erythematous papulonodular lesions in a 48-year-old woman with multiple sclerosis treated with glatiramer acetate and the glatiramoid, Glaotpa. Lesions on the forearm (A and B), and the gluteal region (C) are depicted. Some lesions were associated with scaling. Skin biopsy revealed CD30+ lymphoproliferative disorder consistent with lymphomatoid papulosis. Hematoxylin and eosin staining of the biopsy specimen showed perivascular (white solid arrows) and interstitial (white asterisks) infiltrates of large, atypical mononuclear lymphocytes in a wedge-shaped distribution (white dotted outline) (D). The lymphocytes were diffusely positive for CD30 (Ki-1) (E), and negative for ALK-1 (anaplastic lymphoma kinase-1) (F).
10.1177_11795735211053784-fig1.jpg
PMC8606967_01_10.1177_11795735211053784-fig1.jpg
fig1-11795735211053784
A 48-year-old Caucasian woman with history of relapsing-remitting multiple sclerosis (MS) - diagnosed at age 26 - presented with multiple non-itchy non-tender erythematous papulonodular lesions over her extremities, and trunk (Figure 1, panels A-C). A skin biopsy, 6 weeks after the eruption onset, showed CD30+ lymphoproliferative disorder suggestive of lymphomatoid papulosis (LyP) (Figure 1, panels D-F).