PMC4763582_01
Multiple pink papules and sun-damaged skin of the right cheek
IDOJ-7-49-g001.jpg
PMC4763582_01_IDOJ-7-49-g001.jpg
F1
A 77-year-old man presented for routine skin exam and was noted to have slightly elevated pink papules on both his cheeks [Figure 1].
(a) Dense diffuse lymphocytic infiltrate with a Grenz zone. Hematoxylin and eosin (H and E) stained sections, x40; (b) Monomorphic medium-sized atypical lymphocytes, with blast-like nuclei. H and E stained sections, x400
IDOJ-7-49-g002.jpg
PMC4763582_01_IDOJ-7-49-g002.jpg
F2
A shave biopsy after revealed a dense nodular and diffuse infiltrate of atypical medium-sized lymphocytes [Figure 2A and B].
Immunohistochemical profile of the mantle cell lymphoma, Case 1 x100
IDOJ-7-49-g003.jpg
PMC4763582_01_IDOJ-7-49-g003.jpg
F3
CD5 stained a few reactive T cells, but the tumor cells were negative [Figure 3].
PMC4763582_02
(a) Diffuse lymphocytic infiltrate, H and E stained sections, x100. (b) Atypical medium-sized to large lymphocytes with multiple mitotic figures, H and E stained sections, x600
IDOJ-7-49-g004.jpg
PMC4763582_02_IDOJ-7-49-g004.jpg
F4
A punch biopsy showed a diffuse lymphocytic infiltrate in the dermis [Figure 4].
Immunohistochemical profile of the mantle cell lymphoma, Case 2. x100
IDOJ-7-49-g005.jpg
PMC4763582_02_IDOJ-7-49-g005.jpg
F5
The atypical lymphocytes expressed cyclin D-1, CD5, CD45, CD79a, PAX5, and CD20 [Figure 5].