PMC9149551_01
PMC9149551_02
a NBI of the esophagus in Case 2. Many small holes representing the orifices of EIPD were observed on the mucosal surface. b Many large, cyst-like lesions were formed in the esophageal submucosa. The lining epithelium of some cyst-like lesions was contiguous with the surface epithelium (Case 2, HE stain, x100). c The walls of cyst-like lesions were lined by biphasic epithelial layers: the inner ductal cell layers and outer basal cell layers (Case 1, HE stain, x200). d The lining cells frequently showed squamous metaplasia. Mild inflammatory changes were found in the stroma (Case 2, HE stain, x200). e Cyst-like lesions in EIPD rarely simulated a false diverticulum (Case 2, HE stain, x100). f The luminal surface of the cyst-like lesions was linearly stained blue-purple by PAS-AB stain (Case 2, PAS-AB stain, x200). g Some intralobular terminal ducts of submucosal glands were ectatic and continuous with the cyst-like lesions. Some acinar and ductal cells showed an oncocytic change (Case 1, HE stain, x200). h The acini of submucosal glands were occasionally replaced by metaplastic squamous epithelium, resembling necrotizing sialometaplasia (Case 2, HE stain, x200). NBI, narrow band imaging; PAS-AB, periodic acid-Schiff and Alcian Blue.
crg-0016-0270-g01.jpg
PMC9149551_02_crg-0016-0270-g01.jpg
F1
The small holes were more clearly visualized by narrow band imaging than by white light imaging because the holes (orifices of EIPD) and the surrounding mucosa were clearly depicted on narrow band imaging due to their brown color on the background mucosa showing a pale moss-green color (Fig. 1a).