PMC5591984_01
The imaging studies showed multinodularity (US) (a) and thyroid growth (CAT) (b). Arrows in (b) show an enlarged thyroid gland.
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fig1
IU/mL (normal reference value, 34). Imaging studies demonstrated multinodularity (Ultrasound [US]) (Figure 1(a)), discrete thyroid growth (Figure 1(b)) and the thyroid fine needle aspiration (FNA) biopsy corroborated PTC Bethesda Class V (Figure 2).
Thyroid fine needle aspiration (FNA) biopsy.
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fig2
IU/mL (normal reference value, 34). Imaging studies demonstrated multinodularity (Ultrasound [US]) (Figure 1(a)), discrete thyroid growth (Figure 1(b)) and the thyroid fine needle aspiration (FNA) biopsy corroborated PTC Bethesda Class V (Figure 2).
Diagram of the FOXE1 region marking some single nucleotide polymorphisms (SNPs) reported. The 5' and 3' untranslated regions (UTR) are marked in a blue box, the FOXE1 gene exon is marked in an orange box, the forkhead region is marked in a red box, and the SNPs present in our patient are marked in italic.
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fig3
Based on the contribution of FOXE1 mutations and SNPs variants (Figure 3) in the development of the CL, HT, and PC, we sequenced the exon 1 of this gene (coding region and 3'UTR) in order to identify mutations or SNPs potentially associated with the patient's diseases.