PMC4208430_01
A case of combined HCC (brown cut surface) and FLC (lobulated grey white cut surface):right hepatectomy specimen.
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fig1
Adjoining this tumor was another nodular lesion measuring 8 x 9 x 9 cm with lobulated grey white cut surface (Figure 1).
HCC showing tumor cells arranged in pseudoglandular and trabecular pattern, hematoxylin-eosin 200x.
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fig2
Microscopic examination of the larger brown tumor and the small nodules showed large polygonal cells arranged in pseudoglandular and trabecular pattern (Figure 2) separated by sinusoidal vascular channels.
Fibrolamellar carcinoma showing tumor cells with abundant eosinophilic cytoplasm separated by lamellar bands of hyalinised collagen, hematoxylin-eosin 100x.
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fig3
Sections from the grey white mass showed a tumor with a fibrolamellar pattern composed of trabeculae of large polygonal cells separated by lamellar bands of hyalinized collagen (Figure 3).
Tumor cells showing diffuse granular cytoplasmic positivity for Hep-par 1 in HCC, immunohistochemistry 200x.
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fig4
Immunohistochemistry revealed tumor cells of HCC with diffuse positivity for Hep Par1 (Figure 4) and focal positivity for CK7 (Figure 5) whereas the tumor cells of fibrolamellar-type showed diffuse strong positivity for CK7 (Figure 6).
Tumor cells of HCC showing focal positivity for CK7, immunohistochemistry 100x.
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fig5
Immunohistochemistry revealed tumor cells of HCC with diffuse positivity for Hep Par1 (Figure 4) and focal positivity for CK7 (Figure 5) whereas the tumor cells of fibrolamellar-type showed diffuse strong positivity for CK7 (Figure 6).
Tumor cells of FLC showing diffuse positivity for CK7, immunohistochemistry 100x.
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fig6
Immunohistochemistry revealed tumor cells of HCC with diffuse positivity for Hep Par1 (Figure 4) and focal positivity for CK7 (Figure 5) whereas the tumor cells of fibrolamellar-type showed diffuse strong positivity for CK7 (Figure 6).