PMC5864713_01
A nodule with large localized areas of necrosis under the thyroid capsule (H&E, x40).
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F1
Focal papillary proliferations around large necrosis areas (H&E, x100).
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F2
Thyrocytes of papillary carcinoma with a large oncocytic cytoplasm aligned around the fibrovascular core (H&E, x400).
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F3
Extensive strong positivity with cytokeratin 19 and papillary structures (Immunohistochemistry, x400).
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F4
Focal weak positive staining with HBME 1 (Immunohistochemistry, x400).
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F5
No staining with galectin-3 was observed (Immunohistochemistry, x400).
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F6
Cytologic examination revealed presence of mild hypochromia with large oncocytic morphology, focal overlapping, and infrequent intranuclear inclusion (PAP EA 50, x400).
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F7
Magnetic Resonance Imaging (MRI) showed a 2.5x1.5-cm mass lesion in the right superior mesencephalon.
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F8
During MRI at our center (Fig. 8), a mass was detected in the brain stem. "Astrocytoma," as a 2nd synchronous primary tumor, was detected in the patient who underwent surgery at an external center at the patient's request.