PMC9664010_01
Evolution of pulmonary function tests and weight over time. Abbreviations: ETI: elexacaftor, tezacaftor, ivacaftor; pFEV1%: forced expiratory volume in 1 s as percentage of the predicted value. The time-point zero refers to time of ETI initiation (black vertical line). Time-points after ETI start are noted as positive months and time-points before ETI start as negative months.  line indicates the estimated time of conception line indicates the time of delivery.
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fig1
Before the 31st week, the maternal pFEV1 remained between 35 and 40%, relatively stable compared to the values obtained immediately before the pregnancy (Fig. 1). Four months after delivery, the FEV1 increased to 1.07L, 40% of the predicted value, at a similar level as before pregnancy (Fig. 1).