PMC3700487_01
Nests and trabeculae of tumor cells exhibiting mitoses (arrows). [Hematoxylin and eosin, x400].
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Despite marked cautery artifact, the biopsy of the bladder mass revealed extensive transmural infiltration of the bladder wall by sheets, nests, and trabeculae of malignant cells exhibiting numerous abnormal mitoses and large areas of necrosis (Figure 1).
Positive staining for chromogranin (A) and neuron specific enolase [NSE] (B).
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Immunohistochemistry revealed intense positivity for neuroendocrine markers, specifically neuron specific enolase [NSE] and chromogranin (Figure 2).