PMC9950964_01
Compound nevus with pigment incontinence. a Clinical photograph demonstrating the lesion occupying the left caruncle and involving the plica semilunaris; the surrounding tissue appears healthy. There are no additional features including hairs, feeder vessels, cysts, or satellite lesions. b Excisional biopsy histology (H&E, x100) demonstrating heavily pigmented spindle melanocytes arranged at the epithelial-stromal junction and mature epithelioid nevus cells in the underlying stroma that are associated with abundant melanin-laden macrophages. c Nevus cells stain red with Sox 10 (Sox 10, x200).
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PMC9950964_01_cop-2023-0014-0001-529421_f1.jpg
F1
Anterior segment examination showed a raised, homogenous, pigmented region overlying her left caruncle and clinically involving the plica semilunaris but without scleral extension (shown in Fig. 1). Excisional biopsy showed, in a 5 x 3 mm piece, a 5 mm proliferation of heavily pigmented melanocytes arranged at the epithelial-stromal junction, mature nevus cells, and abundant melanin-laden macrophages in the underlying stroma with no evidence of pagetoid spread or dysplasia, confirming a compound nevus (shown in Fig. 1).