PMC3638498_01
CT of neck. Invading mass of the larynx with subglottic and intralaryngeal extension.
CRIM.OTOLARYNGOLOGY2013-385405.001.jpg
PMC3638498_01_CRIM.OTOLARYNGOLOGY2013-385405.001.jpg
fig1
Particularly, the computed tomography (CT) and magnetic resonance imaging (MRI) of the neck revealed a mass with subglottic extension, starting from the region of the left vocal cord, invading the cricoid cartilage, and expanding in the trachea until the level of 4th thoracic vertebra (Figures 1 and 2).
MRI of neck. Laryngeal mass, starting from the region of the left vocal cord and expanding in the trachea until the level of 4th thoracic vertebra.
CRIM.OTOLARYNGOLOGY2013-385405.002.jpg
PMC3638498_01_CRIM.OTOLARYNGOLOGY2013-385405.002.jpg
fig2
Particularly, the computed tomography (CT) and magnetic resonance imaging (MRI) of the neck revealed a mass with subglottic extension, starting from the region of the left vocal cord, invading the cricoid cartilage, and expanding in the trachea until the level of 4th thoracic vertebra (Figures 1 and 2).
Histopathological examination. (a) and (b) The classical pattern of adenoid cystic carcinoma, with a mixture of cribriform and tubular pattern. (c) and (d) The glandular and solid growth pattern of the adenocarcinoma (NOS).
CRIM.OTOLARYNGOLOGY2013-385405.003.jpg
PMC3638498_01_CRIM.OTOLARYNGOLOGY2013-385405.003.jpg
fig3
The histopathologic (Figure 3) and immunohistochemical examination (Figure 4) revealed the coexistence of two different carcinomas, an adenoid cystic carcinoma and an adenocarcinoma:not otherwise specified (NOS) with poor differentiation. The adenoid cystic carcinoma presented the classical pattern, consisted of uniform appearance of small epithelial cells with mild atypia, minimum mitosis, and mixture of cribriform (mainly) and tubular pattern (Figures 3(a) and 3(b)). By contrast, the cells of adenocarcinoma NOS were larger with intense atypia and glandular or solid growth pattern (Figures 3(c) and 3(d)).
Immunochemistry. (a) Vimentin staining: the cells of the adenoid cystic carcinoma were positive. (b) Keratin 7 staining: the cells of both tumors were positive. (c) and (d) SMA staining: positive for the adenoid cystic carcinoma's cells and negative for the adenocarcinoma. (e) and (f) S100 staining: positive for the adenoid cystic carcinoma's cells and negative for the adenocarcinoma.
CRIM.OTOLARYNGOLOGY2013-385405.004.jpg
PMC3638498_01_CRIM.OTOLARYNGOLOGY2013-385405.004.jpg
fig4
The histopathologic (Figure 3) and immunohistochemical examination (Figure 4) revealed the coexistence of two different carcinomas, an adenoid cystic carcinoma and an adenocarcinoma:not otherwise specified (NOS) with poor differentiation. In immunochemistry analysis, the cells of adenoid cystic carcinoma were positive for vimentin, alpha-SMA, and S-100 protein in contrast with the cells of adenocarcinoma that were negative (Figures 4(a)-4(f)). The cells of both tumors had positive staining for keratin 7 (Figure 4(b)).