PMC10103238_01
Endoscopic images (a) initial colonoscopy images at the time of diagnosis shows marked erythema, absent vascular pattern, and some erosions confined to the caecum and sigmoid colon and (b) after 1-year VDZ therapy with no evidence of active disease.
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The patient underwent a colonoscopy that showed marked erythema, absent vascular pattern, and some erosions confined to the caecum and sigmoid colon (Figure 1); his histopathological analysis report showed oedema, hyperemia, and eosinophilic infiltration in the lamina propria with regular glandular architecture.
Quantification of serum vedolizumab (VDZ) in (a) induction period and (b) maintenance period. Data are presented in pre-VDZ infusion and in pre- and post-haemodialysis.
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We, therefore, hypothesize these could be critical time points for this study.   We observed a slight increase in the VDZ concentration rather than a reduction, both at the second induction infusion (week 2) and at the second maintenance infusion (week 22) (Figure 2).