PMC9083879_01
Photomicrographs of the tumor. A - Diffuse sheets of immature mesenchyme with intervening blood vessels (H&E x400); B - Fascicles of fibroblasts observed in between immature mesenchyme with lobules of adipocytes (H&E x400); C - Dilated blood vessels at the periphery of the lesion (H&E x400); D - Neoplastic cells constituting the immature mesenchyme depicting round to elongated cells with conspicuous nucleoli and scant cytoplasm (H&E x1000).
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The tumor also showed lobules of mature adipocytic tissue (Figures 1A and 1B). Few dilated blood vessels, some with stag-horn morphology were observed, more at the periphery of the lesion (Figure 1C). The immature mesenchyme was characterized by round to elongated cells with vesicular chromatin, inconspicuous nucleoli and moderate amount of eosinophilic cytoplasm (Figure 1D).
Photomicrographs of the tumor. A-D - Foci with sarcomatous morphology. Islands with increased cellularity, nuclear atypia and brisk mitotic activity (arrows) (H&E x1000).
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Photomicrographs of the tumor. A - Neoplastic cells strongly positive for vimentin; B - Smooth muscle actin highlighting the fibroblasts and myofibroblasts; C - Neoplastic cells negative for cytokeratin (CK), Melan A, HMB45, Myogenin, Desmin; D - S-100 immunostain highlights the adipocytes; E - Focal dot-like immunoreactivity observed for CD99; F - CD34 highlights blood vessels while the neoplastic cells are negative. (A-F: immunoperoxidase x400).
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CD34 highlighted the blood vessels while was negative in all other three components (Figures 3A-F).