PMC10115160_01
Evolution of the rash. (A) The early lesions were erythematous macules or papules approximately 1 to 5 mm in diameter that did not blanch on pressure. The erythematous maculopapular rash was mostly distributed on the arms and lower legs but was less distributed in the trunk. (B) The vesicles were pale or yellowish from serous fluid matter. The vesicles slowly become enlarged and ruptured, leaving exuding areas. (C) Skin healing with desquamation.
fcimb-13-1064760-g001.jpg
PMC10115160_01_fcimb-13-1064760-g001.jpg
f1
An erythematous maculopapular rash was distributed on the arms and lower legs but did not involve the trunk ( Figure 1A ). The vesicles slowly became enlarged and ruptured, leaving exuding areas ( Figure 1B ). The skin healed with desquamation ( Figure 1C ).
Human Parvovirus B19-specific nucleic acids were detected in mNGS samples of serum and blister fluid. Sequence distribution map: This part only shows the sequence distribution map of species with >=3 nonrepeat specific sequences detected. (A) Serum samples. The total length covered on the genome is 3623 bp, the coverage is 64.7427%, and the average depth is 1.65X. (B) Blister fluid samples. The total length covered on the genome is 1059 bp, the coverage is 18.9242%, and the average depth is 1.18X.
fcimb-13-1064760-g002.jpg
PMC10115160_01_fcimb-13-1064760-g002.jpg
f2
After transfer to our department, PB19-specific nucleic acids were detected in mNGS samples of the patient's blister fluid and serum, and the fluids were negative for other viral, fungal, or bacterial nucleic acids ( Figure 2 ).
The trend of the mean VIS. #PD, postoperative day; *VIS, Vasoactive-Inotrope Scoring. VIS= dopamine dose (microg/kg/min) + dobutamine dose (microg/kg/min) + 100* epinephrine dose (microg/kg/min) + 10*milrinone dose (microg/kg/min) + 10,000* vasopressin dose (U/kg/min) + 100* norepinephrine dose (microg/kg/min). The hourly doses of the following inotropic and vasoactive medications were recorded every day: dopamine, dobutamine, epinephrine, norepinephrine, milrinone, and vasopressin. The mean VIS was obtained by averaging the hourly scores during 24-hr periods.
fcimb-13-1064760-g003.jpg
PMC10115160_01_fcimb-13-1064760-g003.jpg
f3
After five days of the combined treatment, no further fever or abdominal discomfort was noted, and the patient's circulation gradually stabilized without vasoactive medications ( Figure 3 ).