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(A) Hematoxylin and eosin (H&E)-stained slide of insulinoma (x250 magnification). (B) Immunohistochemical reaction with antibodies to insulin in insulinoma (x125 magnification). (C) Hematoxylin and eosin (H&E)-stained slide of microtumors (x10 magnification). (D) Immunohistochemical reaction with antibodiesto insulin in microadenoma (x10 magnification). Red arrows point to insulin-producing microadenomas. Red stars indicate the microtumors.
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Tumor cells are positive for synaptophysin and chromogranin A, as well as for insulin ( Figures 1A, B ). The cells of microadenomas express insulin and are negative for glucagon and somatostatin ( Figures 1C, D ).