PMC5312185_01
Blue-gray hard plaque with a hypochromic halo on the right breast
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Dermatological examination revealed a blue-gray hard plaque with a hypochromic halo on the right breast (Figure 1).
Dermatoscopic examination revealed a homogeneous blue-gray area and
collision of freckles at the periphery of the lesion
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Dermoscopic examination showed only a blue-gray homogeneous pattern (Figure 2).
Histopathology: dermal involvement represented by the proliferation of
cells, some showing brown pigmentation and other involving thickened
collagen fibers (Hematoxylin & eosin x100)
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Histological sections stained with hematoxylin-eosin showed epidermis with acanthosis and dermis with proliferation of elongated cells showing brown pigmentation or involving thickened collagen fibers (Figures 3 and 4).
High magnification: detail of the brown pigment retention by proliferated
stellate cells. Dilated vessels filled with red blood cells in between
stellate cells (Hematoxylin & eosin x400)
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Histological sections stained with hematoxylin-eosin showed epidermis with acanthosis and dermis with proliferation of elongated cells showing brown pigmentation or involving thickened collagen fibers (Figures 3 and 4).
Perls' staining revealing bluish intracellular iron storage in the form
of hemosiderin (Hematoxylin & eosin x100)
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Perls' staining technique revealed blueness in correspondence to the brown pigment, compatible with hemosiderin (Figure 5).