PMC6488771_01
Partial view of frontal-temporal scalp demonstrating mixed morphology of
lesions.
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Surface texture ranged from peau d'orange and mammilated to smooth and nodular (see Figures 1 and 2).
Lateral view of scalp demonstrating heterogeneity of texture among
lesions.
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Surface texture ranged from peau d'orange and mammilated to smooth and nodular (see Figures 1 and 2).
Vertex of scalp, frankly blue-black plaques clearly visible and surrounded by
slight erythematous-pink plaques.
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Taken from specimen A. At scanning magnification, the biopsy labelled A
displayed a band-like proliferation of deeply pigmented cells in the upper
third of the dermis, reminiscent a pattern seen in cellular blue nevi.
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Occasional small irregular junctional nests of melanocytes were evident (see Figures 4 and 5).
Taken from specimen A. At higher magnification, the cellular infiltrate is
seen to be composed of lightly pigmented melanocytes in the background with
scattered, admixed, deeply pigmented melanophages. Junctional nests of
melanocytes are also evident, a feature not seen in blue nevi.
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Occasional small irregular junctional nests of melanocytes were evident (see Figures 4 and 5).
From specimen B. At scanning magnification, the biopsy labelled B displays a
dense, sheet-like cellular infiltrate in the upper third of the dermis and
in peri-follicular zones.
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The histopathological findings in the second sample (specimen B) differed from those in the first biopsy (see Figures 6-8).
From specimen B. Under higher magnification, the dermal cellular infiltrate
is seen to be composed of non-pigmented, atypical, epithelioid melanocytes
with occasional mitotic figures.
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The histopathological findings in the second sample (specimen B) differed from those in the first biopsy (see Figures 6-8).
From specimen B. An immunohistochemical stain for Ki67 shows prominent
nuclear positivity in lesional cells, indicative of a high proliferative
index.
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The histopathological findings in the second sample (specimen B) differed from those in the first biopsy (see Figures 6-8).