PMC7399133_01
No abnormalities are detectable on the T1-weighted (A) and T2-weighted (B) magnetic resonance imaging (MRI) sequences. The diffusion-weighted imaging (DWI; C) shows the typical features of "cortical ribboning" in the cortex and subcortex of bilateral frontal, temporal, and occipital lobes on DWI (C). On the apparent diffusion coefficient map (ABC; D), there is low signal intensity in the cortex and subcortex of the bilateral frontal, temporal, and occipital lobes.
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F1
However, abnormal high signal in two or more cerebral cortex regions, referred to as "cortical ribboning" (Figure 1), and/or the basal ganglia, was incidentally found in the DWI of all four patients, which alerted physicians to suspect a diagnosis of CJD.
The typical presence of periodic sharp wave complexes (PSWCs) on the electrocephalogram of patient 1.
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F2
Patients 1 and 3 had characteristic period sharp wave complexes (PSWCs; Figure 2) recorded by EEG.