PMC7512088_01
Overview of clinical history and management.
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An overview of her clinical history and management is given in Figure 1.
Abdominal CT scan with right renal mass (white arrowheads) and liver metastases (white arrows). (a) Coronal section. (b) Transverse section.
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She recently presented with a right renal mass, incidentally identified during computerized tomography (CT) scan performed as part of her follow-up (Figure 2).
Metastatic infiltrating lobular breast carcinoma involving ccRCC. (a) At 40X, the encircled metastatic breast carcinoma focus is surrounded by ccRCC. (b) At 200X, intracytoplasmic mucin is apparent.
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Microscopic examination of the biopsy specimen revealed two distinct neoplasms (Figure 3).
A panel of immunohistochemical stains performed supports the morphologic impression of two distinct neoplasms:ccRCC and metastatic lobular breast carcinoma. The neoplastic cells of the ccRCC are negative for GATA3 and ER, but immunoreactive for ECAD and PAX-8. The neoplastic cells of the metastatic lobular breast carcinoma are immunoreactive for GATA3 and ER, but negative for ECAD and PAX-8. Immunostains for CK7, CD10, and RCC antigen are not shown.
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The stains performed included: cytokeratin 7 (CK7), GATA3, estrogen receptor (ER), e-cadherin (ECAD), PAX-8, CD10, and renal cell carcinoma antigen (RCC) (see Figure 4).