PMC8112997_01
Gross examination of the right ovary exhibiting a solid and fleshy mass with a tan-yellow cut surface. Scale bar indicates 1 cm.
CRIPA2021-5545645.001.jpg
PMC8112997_01_CRIPA2021-5545645.001.jpg
fig1
On gross examination, the right ovary was occupied by a 49 x 40 x 26 mm solid and fleshy mass with a tan-yellow cut surface (Figure 1).
Nests of tumor cells intersected by fibrous septa (a). The septa were concentrated by theca-like plump spindle cells (b). Tumor cells were positive for c-kit (c) and podoplanin (d). Stromal cells were positive for SF-1 (e) and P450arom (f). Scale bars indicate 200 mum.
CRIPA2021-5545645.002.jpg
PMC8112997_01_CRIPA2021-5545645.002.jpg
fig2
Microscopically, the mass showed sheets and nests of large polygonal cells intersected by fibrous septa (Figure 2(a)). The septa were concentrated by stromal cells with plump spindle nuclei that resembled theca cells (Figure 2(b)). They also expressed placental alkaline phosphatase, c-kit (Figure 2(c)), and podoplanin (Figure 2(d)), and thus, the tumor was diagnosed with pure dysgerminoma. Stromal cells were positive for steroidogenic factor 1 (SF-1) (Figure 2(e)), P450C17 (17alpha-hydroxylase/17,20-lyase), 3beta-hydroxysteroid dehydrogenase (HSD), P450arom (aromatase) (Figure 2(f)), 17beta-HSD type 1, and steroid sulfatase but negative for 17beta-HSD types 2 and 5, 5alpha-reductases 1 and 2, and estrone sulfotransferase.