PMC6145152_01
Clinical photograph showing numerous erythematous-to-brown papules on the anterior left knee.
CRIDM2018-2812439.001.jpg
PMC6145152_01_CRIDM2018-2812439.001.jpg
fig1
Examination revealed numerous erythematous-to-brown, non-tender papules occurring on the anterior left knee (Figure 1).
(a, b and c) Histology of left knee lesion showing a sarcoidal-type granulomatous reaction. (a) Much of the reticular dermis is occupied by a granulomatous infiltrate (hematoxylin and eosin staining, original magnification x40). (b and c) Individual granulomas are sarcoidal in type, i.e., non-necrotising with a minimal associated lymphocytic infiltrate (so-called "naked" granulomas) (hematoxylin and eosin staining, original magnification x200).
CRIDM2018-2812439.002.jpg
PMC6145152_01_CRIDM2018-2812439.002.jpg
fig2
Skin biopsy showed multiple, variably sized naked sarcoidosis type granulomas scattered throughout the dermis (Figure 2).