PMC7333025_01
(a) A breast lobule shows periductular basement membranes (arrows) thickened by eosinophilic amyloid deposits (H&E, 200x). (b) An atrophic breast lobule and a duct (arrow) are surrounded by eosinophilic amyloid deposits (arrowheads) (H&E, 200x). (c) Congophilic amyloid deposits in periductular basement membranes (arrows) and in perivenular interstitium (arrowheads) (Congo red, 200x). (d) Corresponding image under polarized light shows apple green birefringence of periductular (arrows) and perivenular (arrowheads) amyloid deposits as well as gray-white birefringence of interstitial collagen (Congo red, 200x). (e) A breast lobule with amyloid deposits in periductular basement membranes (arrows) (Congo red, 400x). (f) Corresponding image with apple green birefringence (arrows) under polarized light (Congo red, 400x).
CRIPA2020-8828263.001.jpg
PMC7333025_01_CRIPA2020-8828263.001.jpg
fig1
H&E-stained sections of the 9-gauge vacuum-assisted breast core biopsy showed benign breast parenchyma with amyloid deposits in various stages (Figures 1(a) and 1(b)). Multiple breast lobules had marked thickening of periductular basement membranes by eosinophilic deposits (Figure 1(b)). Ductules surrounded by heavy deposits appeared atrophic or partially replaced by amyloid (Figure 1(b)). Deposits were also present in the periductal and perivascular interstitial areas and in the walls of arteries and veins (Figures 1(c) and 1(d)). Congo red stain highlighted more subtle amyloid deposits in periductular basement membranes (Figure 1(e)). Congophilic deposits demonstrated apple green birefringence under polarized light, while areas of collagenous stroma had gray-white birefringence (Figures 1(d) and 1(f)).