PMC8273731_01
MRI examination. The lesion showed low signals with multiple rooms on T1-weighted images. (A) Contrast-enhanced T1-weighted images showed no lesion enhancement: (B) arterial phase; (C) venous phase. (D) Microscopically, multiple cysts were observed. The inner wall of the cyst was covered with columnar mucous epithelium, the cytoplasm was slightly eosinophilic, and the nucleus was located at the base (HE x200).
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Past History: On December 2, 2011, the patient underwent a left lateral hepatectomy because of abdominal magnetic resonance imaging (MRI) showing a multilocular cystic mass in the left lateral lobe of the liver ( Figures 1A-C ). Postoperative pathology confirmed intrahepatic biliary cystadenoma (IBC) ( Figure 1D ).
Abdominal magnetic resonance imaging (MRI)/computed tomography (CT) scans before and after apatinib therapy. Before apatinib treatment, a CT scan showed a mass with cystic and solid masses. (A) plain scan; (B) arterial phase; (C) venous phase. After 3 months of apatinib treatment, MRI revealed that the tumor mass decreased significantly. (D) T1-weighted image; (E) arterial phase; (F) venous phase.
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After the contrast agent's infusion, the lesions showed inhomogeneous enhancement, with a low-density necrotic area in the arterial phase and decreased enhancement in the venous phase ( Figures 2A-C ). MRI (on May 25, 2017) showed that the tumor had shrunk to 12x9 cm, which indicated that the patient achieved stable disease ( Figures 2D-F ).
CT scan (on January 21, 2021) showing liver mass after 48 months of apatinib treatment. (A) plain scan; (B) arterial phase; (C) venous phase; (D) equilibrium phase.
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No noticeable enhancement was observed ( Figures 3A-D ).