PMC6370057_01
Nail bed solitary neurofibroma - nodular 1 cm white-pink circumscribed solid tumor with important onychodystrophy in the radial side of the left 2nd finger nail bed.
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F1
Thinning and raising on the radial side of the nail plate was noticed (Fig. 1).
Bone distortion without cortical damage or bone invasion.
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F2
Radiological examination revealed bone distortion by compression of the distal phalanx of the left second finger, without cortical damage or bone invasion (Fig. 2).
Optical microscopy of nail bed neurofibroma showing slightly wavy, elongated cells with discrete angled nuclei and interstitial collagen fibers (hematoxylin-eosin x20).
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F3
There were also myxoid areas, thick collagen bands and reduced inflammatory infiltrate (Fig. 3).
Immunochemistry examination: S100 protein staining positive in tumor cell nuclei.
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F4
Immunohistochemical staining for S100 protein was positive (Fig. 4).