PMC2892659_01
Low power view of the tumor showing the expansion of the duct wall with dilation of the lumen (H & E 100x).
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fig1
Histological examination showed large pleomorphic and spindle-shaped cells, focal necrosis, and a mitotic count of > 20 per 10 high power fields, with negative surgical margins (Figures 1 and 2).
High power view showing highly pleomorphic cells and numerous/atypical mitosis (H & E 400x).
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fig2
Histological examination showed large pleomorphic and spindle-shaped cells, focal necrosis, and a mitotic count of > 20 per 10 high power fields, with negative surgical margins (Figures 1 and 2).
Smooth muscle actin immunohistochemical stain shows positive staining in the pleomorphic and spindle tumor cells, indicating smooth muscle origin of this lesion (100x).
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fig3
Immunohistochemical analysis showed tumor cells positive for smooth muscle actin (SMA), desmin, and vimentin and negative for other markers performed (pan cytokeratin, c-kit, CD34, and S-100) (Figures 3 and 4).
Pan-keratin, highlighting the residual ductal epithelium with no staining in tumor cells (100x).
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fig4
Immunohistochemical analysis showed tumor cells positive for smooth muscle actin (SMA), desmin, and vimentin and negative for other markers performed (pan cytokeratin, c-kit, CD34, and S-100) (Figures 3 and 4).