PMC9977208_01
Pink atrophic plaque with linear hyperkeratotic borders, central fissuring, and erosions extending from the right thenar eminence to the first webspace
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FIG1
He denied any pruritus or tenderness in the affected region aside from the areas of denuded skin (Figure 1). Physical examination revealed a pink atrophic plaque with linear hyperkeratotic borders along the right thenar eminence extending to the first webspace (Figure 1).
Punch biopsy demonstrating sharply demarcated hypokeratosis of stratum corneum adjacent to normal-appearing acral skin, a characteristic finding in CPH (Hematoxylin and eosin stain; original magnification X50). CPH: Circumscribed palmar hypokeratosis.
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FIG2
The biopsy revealed a sharply demarcated hypokeratosis of the epidermis with some parakeratosis and basal keratinocyte atypia (Figures 2, 3).
Higher power magnification demonstrating parakeratosis, basal keratinocyte atypia, and lichenoid inflammation (Hematoxylin and eosin stain; original magnification X100)
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FIG3
The biopsy revealed a sharply demarcated hypokeratosis of the epidermis with some parakeratosis and basal keratinocyte atypia (Figures 2, 3).
Small heme-crusted papule in the right first webspace with some faint erythema and scale and otherwise normal skin; this figure shows the improvement at two-month follow-up.
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FIG4
Physical examination revealed a small heme-crusted papule at the right first webspace with some faint scale and erythema and otherwise normal skin (Figure 4).