PMC9454308_01
Immunohistochemistry of CD10+ mantle cell lymphoma. Representative lymph node biopsy demonstrates (A) morphologic features of the mantle cell lymphoma (H&E, x1,000) with immunostaining (B) positive for CD5, (C) positive for cyclin D1, (D) Variabily positive for CD10, (E) negative for CD23, (F) Elevated Ki-67 proliferation index (Overall 40%-70%).
pore-28-1610588-g001.jpg
PMC9454308_01_pore-28-1610588-g001.jpg
F1
Remarkably, CD10 was found to be variably positive in about 70% of tumor cells (Figure 1).
Flow cytometric analysis of bone marrow aspirate revealed a monotypic lambda restricted CD5+/CD10+ B cell population.
pore-28-1610588-g002.jpg
PMC9454308_01_pore-28-1610588-g002.jpg
F2
Flow cytometric analysis of the bone marrow aspirate confirmed the presence of a monotypic, lambda restricted, CD5+/CD10 dim + B cell population (Figure 2).
PET-CT demonstrating hypermetabolic , diffuse wall thickening of the stomach and throughout the small bowel.
pore-28-1610588-g003.jpg
PMC9454308_01_pore-28-1610588-g003.jpg
F3
A positron emission tomography (PET) scan showed hypermetabolic, diffuse wall thickening of the stomach and numerous enlarged mesenteric lymph nodes/diffuse hypermetabolic activity throughout the small bowel (Figure 3).