PMC9636739_01
PMC9636739_02
macroscopic photo of the tumor occupying the hole gallbladder and invading the hepatic parenchyma, the cut section shows a heterogenous appearance with presence of many hemorrhagic and necrotic foci
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F1
Cut section of the mass showed a heterogenous appearance with many diffuse necrotic and hemorrhagic foci (Figure 1).
photomicroph of the carcinomatous component, made of irregular infiltrating tubes, made of markedly atypical large cells, HE; 100X
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F2
Microscopic examination showed a highly malignant neoplastic proliferation with two components: an epithelial, adenocarcinomatous component made of irregular infiltrating tubes, made of markedly atypical cells with large eosinophilic cytoplasm and large nuclei containing prominent nucleoli and showing frequent mitoses (Figure 2).
photomicrograph showing the sarcomatous component, made in this field of markedly atypical spindle cells, few tubes of the epithelial component can also be seen
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F3
Nuclei were hyperchromatic and many mitoses could be observed (Figure 3).
photomicrograph showing presence of cytoplasmic double striations, observed on the rhabdomyosarcomatous heterologous component of the sarcomatous component
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F4
These could be identified after use of the anti-desmin antibody (Figure 4).
(A,B) photomicrograph showing expression of CD31 (left) and CD34 (right) by cells layering the anastomosing channels
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F5
The vascular nature could be confirmed after identifying expression of CD31 and CD34 by neoplastic cells (Figure 5).