PMC7362985_01
(a) T2-weighted axial image on magnetic resonance imaging shows hyperintense mass lesion in the endometrial cavity (white arrow); in addition, there is well-defined hypointense ovoid lesion seen in the right adnexa (black arrow). (b) Nests of urothelial cells with coffee bean nuclei present with abundant fibrous stroma indicating benign Brenner of the ovary (H and E x40). (c) Omentum showing metastatic adenocarcinoma in a case of endometrioid adenocarcinoma (H and E x40). (d) Immunohistochemistry for estrogen receptor showing nuclear positivity only in fibrous stroma of ovarian Brenner tumor (immunohistochemistry x40)
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F1
T2-hypointense lesion with peripheral rim of postcontrast enhancement suggestive of a solid ovarian tumor. The left ovary was normal; there was no ascites or any other intra-abdominal pathology [Figure 1a]. The right ovary revealed nests of transitional cells embedded in fibroconnective tissue suggestive of Brenner tumor [Figure 1b], and omentum showed multiple microscopic metastatic deposits of adenocarcinoma [Figure 1c]. Transitional cells of the Brenner tumor also showed positivity for Cyclin D1 and p63 and were negative for epidermal growth factor receptor (EGFR), Ki-67, and p53 [Figure 1d].