PMC3339688_01
Fundus photographs and OCT images of the right eye. a-c Macular edema was absent at the first visit to our department. d-f Cystoid macular edema emerged at the end of the second S-1 cycle. g-i Macular edema persisted 1 month after an intravitreal injection of 1.25 mg bevacizumab. j-l Macular edema disappeared 3 months after termination of S-1 therapy. a, d, g, j Fundus photographs. b, e, h, k Horizontal line scans through the fovea. c, f, i, l Macular thickness maps.
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F1
Fundus examination revealed scattered blot hemorrhages, cotton wool spots and scattered laser scars (fig. 1a). Macular edema which was examined by optical coherence tomography (OCT; Stratus OCT, Carl Zeiss Meditec, Dublin, Calif., USA) was absent in both eyes (fig. 1b, c). Emergence of cystoid macular edema in the right eye was confirmed by OCT (fig. 1d-f). Macular edema persisted for 5 months despite another IVB (fig. 1g-i). Macular edema disappeared 3 months after termination of S-1 therapy (fig. 1j-l).
Relationship between the time course of anemia and macular edema in the right eye. Upper graph: hemoglobin concentration. The vertical double-headed arrow indicates the normal range. Lower graph: the 1-mm central retinal thickness in OCT images. # Gastrectomy. * Cataract surgery.   Intravitreal injections of 1.25 mg bevacizumab. Boxes in the horizontal axis indicate the periods of S-1 treatment. Horizontal axes of both graphs indicate months after the first visit to our department.
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F2
The time course of the 1-mm central retinal thickness correlated well with that of the severity of anemia (fig. 2).