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Barrett's esophagus with nodularity and high-grade dysplasia (HGD) visualized with HD-WLE (a), i-scan mode 1 (b) and (c), and i-scan mode 3 (d). Histopathology of EMR specimen showing Barrett's esophagus with HGD, H&E stain, and 400x magnification (e).
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EGD with HD-WLE demonstrated 2 cm of Barrett's mucosa (Figure 2(a)). With i-scan activated an erythematous area of nodularity within the Barrett's was better defined (Figures 2(b), 2(c), and 2(d)). Histopathology of the EMR specimen demonstrated high-grade dysplasia (HGD) within the central nodule and surrounding low-grade dysplasia (Figure 2(e)).
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Raised nodule of adenocarcinoma within a segment of Barrett's esophagus as seen with HD-WLE (a), i-scan mode 1 (b), i-scan mode 2 (c), and i-scan mode 3 (d).
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On EGD the patient had 7 cm segment of Barrett's esophagus, with a single are of nodularity as seen on HD-WLE endoscopy image (Figure 3(a)). i-scan Modes 1, 2, and 3 (Figures 3(b), 3(c), and 3(d)) demonstrated the surface enhancement and margins of the nodule, thus targeting EMR.
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Gastric mucosa associated lymphoid tissue (MALT) lymphoma visualized with HD-WLE (a), i-scan mode 1 (b), and i-scan mode 3 (c). Histopathology showing MALT lymphoma, H&E stain, and 400x magnification (d).
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On EGD, in the body and fundus of the stomach, WLE demonstrated pale, atrophic-appearing mucosa that could be consistent with gastritis or gastropathy (Figure 4(a)). i-scan was activated and demonstrated a patch of pale yellow mucosa with surrounding nodular, edematous gastric folds (Figures 4(b) and 4(c)). The histopathology demonstrated low-grade mucosa associated lymphoid tissue (MALT) lymphoma (Figure 4(d)).
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Sessile serrated polyp visualized under HD-WLE (a) and with i-scan mode 2 (b).
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A minimally erythematous flat mucosal abnormality was noted in the ascending colon with WLE (Figure 5(a)). Further characterization with i-scan mode 2 showed a 7 mm polyp that was removed with hot snare (Figure 5(b)).
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Large rectal polyp with focus of adenocarcinoma, visualized with HD-WLE (a), i-scan mode 1 (b), i-scan mode 2 (c), and i-scan mode 3 (d).
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Upon retroflexion in the rectum, another 2 cm sessile polyp was seen (Figure 6(a)). i-scan modes 1, 2, and 3 were turned on and more clearly visualized the extent and borders of this large polyp and defined the lesion edges (Figures 6(b), 6(c), and 6(d)).
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