PMC4785789_01
15-year-old male presented with oral mucosal lesions with encrustation and blisters and abdominal pain diagnosed as due to Castleman's disease. Photograph shows the oral lesions.
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F1
General examination revealed oral lesion [Figure 1], and vague abdomen lump in the right lower abdomen.
15-year-old male child presented with oral ulcers and abdominal pain diagnosed as due to Castleman's disease. Magnetic resonance imaging of the abdomen, axial image shows homogeneous mass 6 cm x 5 cm (arrow) arising from right hemipelvis.
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F2
T1W1 and hyperintense on T2W1 with multiple fine internal septations [Figure 2]. The mass also showed homogenous, intense postcontrast enhancement.
A 15-year-old male child presented with oral ulcers and abdominal pain diagnosed as Castleman's disease with fluorodeoxyglucose positron emission tomography axial image showing faintly fluorodeoxyglucose avid soft tissue mass in the right hemipelvis (arrow).
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F3
Further, positron emission tomography-computed tomography (CT) showed faintly fluorodeoxyglucose avid heterogenous mass arising from the right hemipelvis [Figure 3].
15-year-old male child presented with oral ulcers and abdominal pain diagnosed as due to Castleman's disease., Intraoperative image shows the mass during dissection.
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F4
Mass was circumferentially mobilized and removed preserving major iliac vessels [Figure 4].
15-year-old male child presented with oral ulcers and abdominal pain diagnosed as due to Castleman's disease. Hematoxylin and eosin stained biopsy tissue (x10 magnification) of the oral mucosal lesion shows dense lymphocytic infiltrates (arrow) with capillaries around them. Direct immunofluorescence revealed intraepidermal intercellular staining with immunoglobulin G (not uploaded).
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F5
Final histopathology confirmed Castleman's disease [Figure 5].
15-year-old male child presented with oral ulcers and abdominal pain diagnosed as due to Castleman's disease. Postsurgical resection of abdominal mass cut section of the mass lesion shows healing of the oral lesions.
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F6
Patient is presently on tablet prednisolone 20 mg and oral lesions are healing [Figure 6].