PMC56591_01
A: Medium-power photomicrograph of the colon showing a small epithelioid granuloma (arrow) (Hematoxylin and eosin stain. B: Low-power photomicrograph of bone marrow showing a hypercellular marrow with an epithelioid granuloma (arrow) (Hematoxylin and eosin stain).
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F1
Although both studies were endoscopically normal, histopathology of random mucosal biopsies revealed characteristic features of Crohn's disease with granulomas in the colon and erosive duodenitis with a single granuloma in the small bowel (Figure 1).
Liver biochemical profile. The patient had a normal serum alkaline phosphatase and bilirubin level 14 days prior to presentation. The marked intrahepatic cholestasis did not improve until initiation of steroids on day #14. At post-discharge follow-up on day #40, both the serum alkaline phosphatase and bilirubin had normalized. * = Upper limit of normal
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F2
There were also concomitant improvements in her hematological and liver profiles (Table 1, Figure 2).