PMC7094532_01
Chest radiograph of patient 1, demonstrating a fine nodular interstitial pattern, especially at the bases.
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The chest radiograph demonstrated a fine nodular interstitial pattern (Fig 1 ).
Left, A: lung micrograph of patient 1 showing granulation tissue (Masson's body, arrow), projecting into a respiratory bronchiole through the site indicated by the dashed arrow (pentachrome, original magnification x200). Note the presence of mucus more proximally in the bronchiolar lumen. Right, B:granulation tissue cast filling an alveolar duct (arrow). Note the presence of branching cast of granulation tissue composed of elongated fibroblasts admixed with lymphoplasmacytic infiltrate (hematoxylin-eosin, original magnification x400).
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This revealed extensive proliferative (exudative) bronchiolitis with organizing pneumonia consistent with BOOP (Fig 2 ).
PMC7094532_02
Top: Posterior view of 99mTc-DTPA aerosol ventilation scan of patient 2 showing severely reduced ventilation to the left lung, with a more patchy decrease in ventilation of the right lung. Bottom:corresponding image of 99mTc-MAA perfusion scan shows matching areas of decrease in perfusion.
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A ventilation-perfusion lung scan revealed a marked decrease in both ventilation and perfusion on the left (Fig 3 ).
HRCT scan of patient 2, retargeted to the left lung, shows fine centrilobular nodules (arrows) compatible with an inflammatory bronchiolitis.
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The high-resolution CT (HRCT) scan revealed fine centrilobular nodules throughout the left lung (Fig 4 ).
PMC7094532_03
HRCT scan of chest of patient 3 shows diffuse centrilobular nodularity ("tree in bud" appearance, arrow) consistent with inflammatory bronchiolitis.
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HRCT of the chest revealed multiple tiny and indistinct nodular opacities with a branching pattern ("tree in bud") in the periphery, consistent with bronchiolitis (Fig 5 ).