PMC3119581_01
Abdominal computed topography finding. Arterial phase computed tomography shows no abdominal mass, but ascites.
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Ascites, but no abdominal mass, were detected (Figure 1).
Needle biopsy specimen of the liver.. Notes: A) Low magnification of silver impregnation staining for reticulin showing broad areas of parenchymal collapse. B) High magnification of a hematoxylin and eosin stained section showing interfacial hepatitis (arrow). C) High magnification of a hematoxylin and eosin stained section showing non-destructive cholangitis (black arrowhead) and destructive cholangitis (white arrowhead) surrounded by numerous plasma lymphocytic cells.
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Histological examination showed severe lobular necrosis, inflammation with broad areas of parenchymal collapse, and both nondestructive and destructive cholangitis surrounded by many lymphocytes and plasma cells (Figure 2).
Electron microscopy findings.. Notes: Migrating lymphocytes were found more frequently in a medium-sized interlobular bile duct surrounded by many inflammatory cells. One lymphocyte had just migrated through the bile duct epithelial cells. Complete absence or partial loss of microvilli and microvillous bleb formation was visible in the same bile duct epithelial cell. The arrow indicates bleb formation. The arrowhead denotes migrating lymphocytes through the bile duct epithelial cells.
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Complete absence or partial loss of microvilli and microvillous bleb formation was visible in the same bile duct epithelial cell (Figure 3).
Clinical course.
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They were normalized after 1 month (Figure 4).