PMC10187577_01
Clinical photograph of the patient: Initial photograph of the patient.
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A 58-year-old male presented with a red papule on the lateral side of his left knee 6 months ago with no apparent cause, after which the papule gradually increased in size to 2*3 cm (Figure 1) and was seen at an outside hospital, where he was diagnosed with "keloid". "Compound Betamethasone injection 1mL topical injection" once a month for 4 times, Subsequently, the lesion increased in size to 7*8 cm irregular plaque, with ulceration and crusting on the surface, several small papules appear in the periphery (Figure 2).
Clinical photograph of the patient: after topical injections of compound betamethasone injections 1 mL x 4 times.
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A 58-year-old male presented with a red papule on the lateral side of his left knee 6 months ago with no apparent cause, after which the papule gradually increased in size to 2*3 cm (Figure 1) and was seen at an outside hospital, where he was diagnosed with "keloid". "Compound Betamethasone injection 1mL topical injection" once a month for 4 times, Subsequently, the lesion increased in size to 7*8 cm irregular plaque, with ulceration and crusting on the surface, several small papules appear in the periphery (Figure 2).
Histopathology of skin lesions: Diffuse infiltration of tumour cells in the dermis and subcutaneous tissues, with large tumour cells, abundant cytoplasm, round or irregular nuclei, obvious nucleoli, obvious heterotypes, obvious interstitial phenomenon, and focal infiltration of surrounding lymphocytes (HEx100).
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Histopathology of skin lesions: with large tumour cells, abundant cytoplasm, round or irregular nuclei, obvious nucleoli, obvious heterotypes, obvious interstitial phenomenon (HEx200).
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Mmunohistochemistry: CD30 (+++)(IHC x100).
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Mmunohistochemistry: CD30 (+++) (IHC x200).
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Clinical photograph of the patient: After 6 rounds of chemotherapy with the CHOP regimen.
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Six rounds of chemotherapy with the CHOP regimen were administered in June 2022, and the lesions gradually subsided (Figure 7).