PMC9808156_01
The time course of platelet (Plts) and white blood cell (WBC) counts is shown. Plts continued to decline drastically from Day2 to Day4. WBC extremely increased until Day3. Then they started to improve. Each arrow indicates the timing of administration of methylprednisolone, platelet concentrate, AT substitution, and FFP. Also, each trapezoid or polygon shows the duration of oxygen inhalation (2-4 litters/min), the dose of norepinephrine (mug/kg/min), and the dose of dopamine (mug/kg/min). The upper and lower horizontal lines indicate normal values for Plts (lower bound) and WBC (upper limit).
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NE of approximately 0.9 mug/kg/min and DOA of 5 mug/kg/min were required until his systolic blood pressure reached 90 mmHg and stabilized (Figure 1). Septic DIC appeared to be progressing rapidly (Table 1, Figure 1), yet no massive hemorrhage was observed. Transfusion of fresh frozen plasma (FFP) from Day3 to Day10, and treatment with antithrombin (AT) substitution from Day3 to Day5 was performed (Figure 1). Finally, on Day5, we started platelet concentrate (PC) transfusions (Figure 1). He continued to get well and was able to begin peroral intake on Day8, and Plts reached normal levels on Day16 (Figure 1, Table 1).