PMC6010930_01
(A) Hematoxylin and eosin (H&E) stain of lymph node biopsy showing foamy histiocytes (arrows) and scattered acute inflammation. (B) H&E stain of duodenal mucosa biopsy with marked infiltration of the lamina propria with foamy histiocytes (arrow). (C) Periodic acid-Schiff with diastase (PAS-D) stain of duodenal mucosa biopsy showing strong positivity within histiocytes (arrow).
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Histologic examination of the spleen was benign; however, the enlarged mesenteric lymph node was found to have foamy histiocytes and scattered acute inflammation (Fig. 1A). Mucosal biopsy of the duodenum demonstrated extensive infiltration of the lamina propria by foamy histiocytes and periodic acid-Schiff diastase (PAS-D) stain demonstrated strong positivity within histiocytes (Fig. 1B,C).