PMC5726706_01
Erythematous, edematous annular plaques with centrifugal growth
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f1
Forty-one-year-old female patient, phototype IV, with recurrent, itchy, erythematous-edematous annular plaques, with overlying vesicles and crusts on the trunk and limbs for 3 years (Figures 1 and 2).
Erythematous, edematous plaques with overlying vesicles in a herpetiform
pattern
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f2
Forty-one-year-old female patient, phototype IV, with recurrent, itchy, erythematous-edematous annular plaques, with overlying vesicles and crusts on the trunk and limbs for 3 years (Figures 1 and 2).
Exocytosis and mild acantholysis simulating spongiosis, besides
predominantly mononuclear perivascular inflammatory infiltrate
(Hematoxylin & eosin, X100)
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f3
Histopathology revealed mild acantholysis simulating spongiosis, exocytosis and perivascular inflammatory infiltrate in one of the biopsies, and acantholytic vesicle containing neutrophils and eosinophils in the other (Figures 3 and 4).
Intraepidermal acantholytic blister with numerous eosinophils, also seen
in the adjacent epidermis (Hematoxylin & eosin, X100)
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f4
Histopathology revealed mild acantholysis simulating spongiosis, exocytosis and perivascular inflammatory infiltrate in one of the biopsies, and acantholytic vesicle containing neutrophils and eosinophils in the other (Figures 3 and 4).
Deposition of IgG in an intercellular pattern all over the epidermis
(IFD, X100)
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f5
DIF demonstrated intercellular IgG and C3 in the epidermis, in a pemphigus pattern, ruling out the previous suspicions of DH, that would present with a deposit at the top of dermal papillae and LABD, that would present with a linear deposit of IgA along the basement membrane zone (Figure 5).