PMC10162882_01
(a) Large solid-cystic mass with calcifications, distorting pancreas. (b) Large mass originating from the body and tail of the pancreas abutting the left kidney and spleen.
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fig1
Computerized tomography (Figures 1(a) and 1(b)) demonstrated a very large mass with solid and cystic features in addition to calcifications originating from the body and tail of the pancreas which was grossly distorted and irregular.
(a) 15.5 cm pancreatic mass attached to the colon and intact spleen. (b) Encapsulated cystic, hemorrhagic, and solid mass in the tail of the pancreas.
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fig2
Findings on gross examination (Figure 2(a)) showed a large, encapsulated mass of approximately 15 cm occupying the tail and body of the pancreas that was adherent to the splenic flexure of the colon. The tumor was serially sectioned (Figure 2(b)) to reveal cystic and solid cut surface with focal necrosis, calcifications, and cysts containing bloody fluid.
(a) Monomorphic cells with solid and pseudopapillary architecture admixed with hyalinized to myxoid stroma. (b) Immunochemical stain for beta-catenin nuclear was strongly positive. The beta-catenin staining was done using a Ventana Benchmark Ultra Instrument and the Ventana Optiview DAB staining kit. The antibody was Clone 14 from Ventana Medical Systems (Oro Valley, Arizona, USA).
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fig3
On microscopic examination (Figure 3(a)), the tumor was found to be composed of monomorphic cells with solid and pseudopapillary architecture mixed with hyalinized to myxoid stroma with degeneration and dystrophic calcification. Immunohistochemistry revealed the tumor to be positive for nuclear beta-catenin (Figure 3(b)) and low molecular keratin Cam 5.2.