PMC5660822_01
MRI of the brain displaying left frontoparietal dominant extracranial soft tissue lesion.
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Further imaging of the mass was ordered with an MRI of the brain which showed focal cranial bone marrow infiltration and a left frontoparietal 6 x 2 x 9 cm dominant extracranial soft tissue lesion (Figure 1) with thickened enhanced dura below this site.
Biopsy of this lesion confirmed an EBV positive B-cell lymphoma. (a) Histology showed large atypical lymphocytes; hematoxylin and eosin (H&E) (x40 magnification). (b) Immunostaining revealed that these lymphocytes were CD20 positive. (c) In situ hybridization with EBV-encoded small RNA (EBER) was additionally positive (x40 magnification).
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A core biopsy of the mass revealed large atypical lymphocytes (Figure 2(a)) that stained positive for the B-cell marker CD20 (Figure 2(b)), with a high Ki-67 proliferative index and positive EBER staining (detecting for in situ EBV replication) (Figure 2(c)).