PMC7118407_01
Radiographic images of this case. (A) Chest CT finding. Diffuse thin-walled cysts are typical features of LAM. (B) Magnetic response images of the neck mass. The well defined mass (arrow) was hypointense in T1-weighted sequences (a) and hyperintense in T2-weighted sequences (b). (C) 18F-fluorodeoxyglucose-positron emission tomography. Abnormal uptake was observed at the mass (arrow).
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A chest computed tomography (CT) showed multiple, thin-walled cysts on both lungs (Fig. 1A). Magnetic resonance imaging (MRI) revealed well-defined mass, the content of which was hypointense in T1-weighted sequences (Fig. 1Ba) and hyperintense in T2-weighted sequences (Fig. 1Bb). 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed uptake in the mass with a maximal standardized uptake value of 28.9 (Fig. 1C).
Histological findings of the resected cervical mass. Atypical cells with high N/C ratio, large nuclei and clear cytoplasm proliferated diffusely. Tumor cells were immunopositive for leukocyte common antigen, CD20, CD10 and Bcl-6, but negative for HMB-45 and MUM-1. CD-3-positive small T lymphocytes were scattered. Around 70-80% of the tumor was classified as DLBCL, germinal center type.
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Ki-67 (clone MIB-1) labeling index was 70-80% (Fig. 2).