PMC8169051_01
(A and B) Computer tomography showed a mass in the shallow lobe of the left parotid gland. (C) Post-operative pathology indicated that the patient had duct carcinoma of the parotid gland. (D) Emission computed tomography revealed multiple bone metastases involving the spine, ribs, and pelvis before androgen deprivation therapy. (E) Androgen receptor immunohistochemistry showed a strong positive reaction in tumour cells. (F and G) Positron emission tomography and computed tomography (PET-CT) showed no significant evidence of bone metastases after androgen deprivation therapy.
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Computer tomography (CT) of the parotid gland identified a mixed tumour that had undergone malignant transformation (Figure 1A and B). Post-operative pathology indicated that the patient had duct carcinoma of the parotid gland (Figure 1C) with invasion to surrounding soft tissues. Emission computed tomography revealed multiple bone metastases involving the spine, ribs, and pelvis (Figure 1D). In addition, immunohistochemistry showed strong positive staining for androgen receptor (AR) expression (Figure 1E). After 7 months of combined androgen blockade (CAB) therapy, the patient's backache symptoms had resolved, positron emission tomography and computed tomography (PET-CT) showed no significant evidence of bone metastases (Figure 1F and G), and his serum CA724 levels had returned to near-normal levels.