PMC3741076_01
Acute glomerular lesion.. Notes: There is global thickening of glomerular capillary walls caused by subendothelial expansion associated with focal mesangiolysis and a few capillary thrombosis (HES x400 magnification).. Abbreviation: HES, hematoxylin, eosin, saffron.
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A few glomeruli presented with capillary-loop double contours, fibrin thrombi, and zones of mesangiolysis (Figure 1).
Acute arteriolar lesion.. Notes: Mucoid intimal thickening with focal fibrinoid necrosis is responsible for occlusion of the lumen (HES x400 magnification).. Abbreviation: HES, hematoxylin, eosin, saffron.
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One arteriole showed marked mucoid intimal expansion with focal fibrinoid necrosis (Figure 2).
Severe chronic ischemic changes.. Notes: There is diffuse interstitial fibrosis with focal tubular atrophy. The three glomerular (on the left) show severe wrinkling of the basement membranes with sclerotic changes. The interlobular artery shows marked intimal fibrous thickening with resultant severe narrowing of the lumen (trichrome x200 magnification).
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Chronic ischemic changes were predominant, with diffuse interstitial fibrosis, tubular atrophy, extensive ischemic changes in glomeruli, and severe fibrous intimal thickening of interlobular arteries (Figure 3).