PMC4915058_01
Summary of the patient's hospital stay including changes in laboratory results and treatment. Dotted lines indicate grade 3 adverse events according to the Common Terminology Criteria for Adverse Events, Version 4. AST indicates aspartate transaminase; ALT, alanine transaminase; CK-MB, creatinine kinase isoenzyme MB; CK, creatinine kinase; ULN, upper limit of normal; AE, adverse event; IPI, ipilimumab; NIVO, nivolumab; Trach, tracheostomy; IVIG, intravenous immunoglobulin
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PMC4915058_01_40425_2016_139_Fig1_HTML.jpg
Fig1
His muscle strength and laboratory tests improved after the initiation of steroids (Fig. 1). These treatments resulted in improvement of his antibody titer and other laboratory tests (Fig. 1).
Negative CD3 staining of patient's muscle biopsy, (20X)
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PMC4915058_01_40425_2016_139_Fig2_HTML.jpg
Fig2
We analyzed the muscle biopsy, which did not show any immune cell infiltration and this was likely due to the fact that the patient already received immunosuppressive therapies prior to the biopsy (Fig. 2).