PMC2823042_01
A verrucous and pedunculated mass on the left vulva.
ymj-46-155-g001.jpg
PMC2823042_01_ymj-46-155-g001.jpg
F1
Physical examination revealed a 2.5 cm pedunculated, cauliflower-like mass with a verrucous surface on the left side of the vulva (Fig. 1).
(a) A papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis (haematoxylin and eosin; original magnification: x 40). Round and tapering dermal papillae with a fibrovascular core (x100). (b) Invasion of the dermis by irregularly shaped, jagged nests of epithelium, the cells which are predominantly mature squamous cells showing atypicality (haematoxylin and eosin; original magnification: x50). The invading tumor masses are composed of atypical squamous cells (x 200). (c) Cells within the tumor nest demonstrate koilocytosis with large, wrinkled, hyperchromatic nuclei, and horn pearl is present (haematoxylin and eosin; original magnification: x400).
ymj-46-155-g002.jpg
PMC2823042_01_ymj-46-155-g002.jpg
F2
The dermal papillae had round or tapering, pointed ("spiked") tips, and a central thin fibrovascular core (Fig. 2a). The dermis showed a marked inflammatory reaction (Fig. 2b).
HPV DNA chip microarray format (Left). DNA chip microarray for HPV types show the presence of other type HPV DNA in this case, but not the high and low risk HPV types. (Left: DNA chip microarray format; right: results in this case, other HPV DNA types positive.)
ymj-46-155-g003.jpg
PMC2823042_01_ymj-46-155-g003.jpg
F3