PMC6288710_01
Electrocorticograms with first seizures recorded by the RNS  System. (a) Patient 1 had her first seizure 7.5 months after implantation of the RNS System. Electrographic seizure onset (arrowhead) involves low-voltage fast activity arising from cortex overlying the periventricular nodular heterotopia (PVNH) with rapid spread to the hippocampus and then to the PVNH. (b) Patient 2 had his first seizure 49 days after implantation of the RNS System. Electrographic seizure onset (arrowhead) involves rhythmic alpha frequencies arising from the hippocampus without involvement of orbitofrontal cortex.
gr1.jpg
PMC6288710_02_gr1.jpg
f0005
His first seizure occurred 49 days later, and ECoG revealed hippocampal onset (Fig. 1b).
PMC6288710_02
Electrocorticograms with first seizures recorded by the RNS  System. (a) Patient 1 had her first seizure 7.5 months after implantation of the RNS System. Electrographic seizure onset (arrowhead) involves low-voltage fast activity arising from cortex overlying the periventricular nodular heterotopia (PVNH) with rapid spread to the hippocampus and then to the PVNH. (b) Patient 2 had his first seizure 49 days after implantation of the RNS System. Electrographic seizure onset (arrowhead) involves rhythmic alpha frequencies arising from the hippocampus without involvement of orbitofrontal cortex.
gr1.jpg
PMC6288710_02_gr1.jpg
f0005
His first seizure occurred 49 days later, and ECoG revealed hippocampal onset (Fig. 1b).