PMC5256675_01
PMC5256675_02
PMC5256675_03
Evolution of forced expiratory volume in 1 s (FEV1% predicted) (A), body mass index (BMI) (B) and Bhalla computed tomography score (C) in two siblings with cystic fibrosis. The target of 50th percentile of BMI for age is showed on the dotted line (B). She never achieved the target of 50th percentile of BMI for age, which he passed eventually in the first 5 years of follow-up. The female's FEV1 was 50.9% at her first spirometry at 7 years and 7 months of age. Her FEV1 improved to 62.9% in 2 years and declined to 36% in the next 42 months. At 7 years of age, his FEV1 was 69.1%, and in the next 2 years, it improved to the normal range. However, between 15 and 18 years of age, there was a faster FEV1 decline to 38%. During the 6 years we were able to measure the lung function of both siblings, his FEV1 measures were 35% higher than hers. However, the female also exhibited a faster decline of FEV1 in the last 4 years, to 32%.
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fig1
The comparisons of lung function (forced expiratory volume in 1 s - FEV1), BMI and Bhalla CT score in two siblings were done at the same age and are presented in Fig. 1.
Patients' A. xylosoxidans characteristics (ST201). Female (A), male (B) and box plot diagram showing that swimming did not reach a statistical significant difference (C). Only one colony per sputum of different visits was included for analysis. omega: a weak biofilm producer isolate (all remaining isolates were strong biofilm producers); CF: an isolate resistant to ciprofloxacin; S: an isolate resistant to thimethoprim-sulfamethoxazole (most isolates were susceptible to all antibiotics tested); X: susceptibility data not available.
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fig2
All isolates were susceptible to IMP and CAZ (Fig. 2). The results are presented as the median diameters obtained in 3 independent assays performed in triplicate (Fig. 2).