PMC7522582_01
CT abdomen (portal venous phase) transversal plane (A), coronal plane (B) and macroscopic finding (C) with gallbladder (red) and metastasis (blue).
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Macroscopically, a slight discoloration was seen on the anterior surface of the gallbladder, which revealed itself as a 1 cm intravesical tumor nodule on palpation (Fig. 1).
A (H&E1, 40x) In the overview of the gallbladder an intramural vital amelanotic metastasis and a necrotic metastasis of the melanoma surrounded by scar tissue is visible.. -B (H&E, 100x) Necrotic metastasis surrounded by scar tissue and a dense lymphohistiocytic infiltrate.. -C (H&E, 200x) Vital amelanotic tumor with numerous mitotic figures and tumor-infiltrating lymphocytes.. -D (CD82, 200x) Immunohistochemically, the tumour-infiltrating lymphocytes are cytotoxic T lymphocytes.
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Daud et al. (Fig. 2A-D). Due to the renewed flare-up of the skin exanthem immediately prior to the planned surgery, another short-term therapy with prednisone was necessary.