PMC6409063_01
Pathological microscopic examination. (a-b) 20X-40x. Hematoxylin-Eosin shows replacement of endometrial stroma by tumor cells, solid architecture with infiltrative growth as single cells was shown, and discohesive cells are observed with plasmacytoid and "signet ring" morphology with scant cytoplasm and rejected hyperchromatic nucleus. (c) 20x. Mammaglobin immunohistochemistry staining shows positivity in malignant cells. (d) GATA3 immunohistochemistry staining shows strong nuclear positivity in malignant cells. (e) 20x estrogen receptor immunohistochemistry staining shows strong nuclear positivity. (f) 20x PAX-8 immunohistochemistry was negative. (g) 20x vimentin immunohistochemistry staining shows positivity just in blood vessels but it is negative in malignant cells. (h) CDX-2 immunohistochemistry staining shows negativity discarding an origin in digestive tract.
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fig1
The first diagnostic impression was a metastasis from primary cancer in the patient, to corroborate it immunohistochemistry staining (IHC) were requested and endometrial specimens were positive for GATA-3, ER and mammaglobin antigens and negative for PAX-8, CDX-2, and vimentin (Figure 1).