PMC4344966_01
Large anaplastic cells with prominent nucleoli admixed with histiocytes and many eosinophils (A&B) show diffuse positive immunoreaction to Leukocyte common Antigen (LCA) (C).
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F1
The anaplastic cells exhibited positive immunoreactions for leukocyte common antigen (LCA), CD3, CD30 (Figure 1A) and granzyme B (Figure 1B). However, they were negative for AlK (Figure 1C), epithelial membrane antigen, cytokeratin, CD 5, CD 7 and CD20.
Positive immunoreactivity of lymphoma cells to CD30 (A) and Granzyme B (B) both with paranuclear pattern (arrows) and negative immunoreactivity to AlK (C).
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F2
The final diagnosis was ALK-negative ALCL (Figure 2A-C).