PMC4323914_01
Microscopy of renal biopsy (a: x10; b: x40) showing acute interstitial nephritis
IJN-25-54-g001.jpg
PMC4323914_01_IJN-25-54-g001.jpg
F1
Moderate interstitial round cell infiltrates [Figure 1] were seen along with few eosinophils.
Serum creatinine over period after starting atorvastatin 20 mg (solid line) and after rechallenge with another statin, rosuvastatin 10 mg (interrupted line). Black arrow indicates initiation of corticosteroid; white arrow, indicates withdrawal of statin
IJN-25-54-g002.jpg
PMC4323914_01_IJN-25-54-g002.jpg
F2
The response to corticosteroid was good and SCr improved to 1.3 mg/dl at the end of 2 months [Figure 2]. SCr was 1.4 mg/dl at the initiation of rosuvastatin therapy and gradually increased to a peak of 1.8 mg/dl at 4 weeks [Figure 2]. Serum CK was normal (55 U/L) and there was no evidence of any other etiologic factor to account for