PMC8607527_01
Clinical features of the patients. (A and B) MRI of patients P1, P2 and P3 showing white matter changes and symmetric lesions in different regions of the brain, red arrow indicated altered brain region. (C) Elevated lactate in each patient measured by MR spectroscopy, indicated by red arrow.
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PMC8607527_01_1415-4757-GMB-44-4-e20210149-gf1.jpg
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A new MRI showed increased hyperintense lesions in T2 and hypointense lesions in T1, affecting the central portions of the upper segment of the cervical spinal cord (Figure 1, P1: A-B). Symmetric lesions also increased when compared with the first MRI, mainly affecting the mesencephalon, pons, medulla oblongata, cerebellum and upper portions of the cervical spinal cord with an elevation of lactate detected by MR spectroscopy (Figure 1, P1: C).