PMC7328213_01
The pyrosequencing analysis showed the exon 15 V600E hot spot
BRAF mutation.
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PMC7328213_01_10.1177_1756284820927305-fig1.jpg
fig1-1756284820927305
Conversely the pyrosequencing showed the exon 15 V600E hot spot BRAF mutation (Figure 1).
CT-scan at base line (a), after 2 months of regorafenib (b) and after 5 months of
regorafenib (c).
10.1177_1756284820927305-fig2.jpg
PMC7328213_01_10.1177_1756284820927305-fig2.jpg
fig2-1756284820927305
In March 2019 a CT-scan revealed in the left hypochondrium, close to the surgical clips, a solid nodular formation delimited with a central hypodense area measuring 39 x 36 mm in size, involving an ileal loop, associated with an increase in density with thickening of the intestinal loops, suggestive for relapse (Figure 2a). A first restaging CT-scan performed after 2 months of treatment showed a decrease of the thickening of the intestinal loops and a complete necrosis of the solid nodular formation described previously (Figure 2b). A second CT-scan performed after 5 months of treatment showed a complete radiological response (Figure 2c).