PMC5353283_01
Topical terbinafine-induced subacute cutaneous lupus erythematosus. Scaling erythematous plaques with hyperpigmented borders and erosive, indurated plaques interdigitally.
lupus2017000207f01.jpg
PMC5353283_01_lupus2017000207f01.jpg
LUPUS2017000207F1
Physical examination revealed well-demarcated, scaling, erythematous plaques with hyperpigmented borders and some erosive, indurated plaques interdigitally and on the dorsum of the hands (figure 1).
(A) Topical terbinafine-induced subacute cutaneous lupus erythematosus (SCLE). H&E stain revealed hyperkeratosis, superficial and deep perivascular lymphohistiocytic infiltrate, vacuolar changes and deposits of connective tissue mucin in dermis. (B) Topical terbinafine-induced SCLE. Colloidal iron stain revealed increased deposits of connective tissue mucin throughout the dermis, most prominent in the reticular dermis.
lupus2017000207f02.jpg
PMC5353283_01_lupus2017000207f02.jpg
LUPUS2017000207F2
No spongiosis was noted (figure 2A,B).