PMC5485266_01
(a) Bone marrow aspirate showing an amorphous necrotic material (Giemsa stain x100). (b) Extensive BMN in the trephine biopsy (H&E x4). (c) Dilated sinus full of sickle cells in a background of ill-defined eosinophilic material (H&E x40). (d) Intact area with erythroid hyperplasia (H&E x40). (e) Spectrin stain showing the extent of erythroid hyperplasia (IHC, spectrin x10).
CRIHEM2017-7185604.001.jpg
PMC5485266_01_CRIHEM2017-7185604.001.jpg
fig1
The bone marrow biopsy revealed extensive bone marrow necrosis involving more than half of the one centimeter length biopsy, markedly increased erythropoietic activity in the intact area, and dilated sinusoids which were full of sickled red blood cells (Figure 1).