PMC3507070_01
Primary sphenoid sinus esthesioneuroblastoma (ENB). (a) Tissue section demonstrating tumor with small blue round cell morphology (H and E, at x20). (b) Positive immunostaining of the tumor for synaptophysin (at x20)
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F1
The combined morphologhical and immunohistochemical features were most compatible with the diagnosis of sphenoid sinus ENB [Figure 1].
Fine needle aspiration specimen of the sternal mass with metastatic ENB. (a) Low power view of the air-dried smear showing high cellularity of the tumor with focal nuclear chromatin smearing and necrotic background (Diff-Quik stain, at x20). (b) High power view of the air-dried smear demonstrating two-cell population of the tumor: Large viable tumor cells with scant cytoplasm and nuclear molding and small tumor cells with apoptotic nuclei (Diff-Quik stain, at x60). (c) High power view of the alcohol-fixed smear demonstrating tumor cells scattered singly and in small clusters; note evenly dispersed nuclear chromatin (Pap stain, at x60). (d) Positive immunostaining for synaptophysin (cell block, at x20)
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F2
By immunohistochemistry, the tumor cells showed strong staining for synaptophysin and focal staining for chromogranin [Figure 2].