PMC4898367_01
Macroscopic aspects of the tumor after the en-block removal
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Fig1
The cut surface of the tumor was firm tan-gray, lobulated, measuring 6 x 5,5 x 5 cm, with, apparently normal looking, salivary gland tissue at the peripheral margin (Fig. 1).
Low magnification of the tumor within to the parotid parenchyma
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Fig2
Histopathological examination revealed a lobulated tumor with expansive growth within parotid parenchyma (Fig. 2).
The tumor lobules composed of large foamy cells surrounded by basaloid cells
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Fig3
It was composed of nests of two cell populations : large foamy cells with centrally located nuclei and vacuolated clear cytoplasm, surrounded by closely packed smaller basaloid cells with scanty cytoplasm (Fig. 3).
numerous cells with sebaceous differentiation
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Fig4
Large tumor cells showed sebaceous differentiation (Fig. 4), with cellular pleomorphism, high mitotic activity (Fig. 5) and necrosis.
Immunohistochemistry shows positive staining for EMA
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Fig6
Immunohistochemical staining of the tumor showed expression of epithelial membrane antigen (EMA) (Fig. 6), pancytokeratin, and p63 in all neoplastic cells, and focaly B-Catenin.
Immunohistochemistry shows positive staining for MSH2 in tumor cells and lymphocytes
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Fig7
Strong nuclear expression of both proteins was found (Figs. 7 and 8).
Immunohistochemistry shows positive staining for MLH1 in tumor cells
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Fig8
Strong nuclear expression of both proteins was found (Figs. 7 and 8).