PMC5843845_01
Proteus syndrome: Modestly developed connective tissue nevus of the left foot, previously misdiagnosed as a keloid.
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A 49-year-old woman presented with a 10-year history of pauci-symptomatic infiltrating plaque lesions on the sole and lateral margin of the left foot ( Figure 1 and Figure 2).
Proteus syndrome: Lateral view of the affected foot.
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A 49-year-old woman presented with a 10-year history of pauci-symptomatic infiltrating plaque lesions on the sole and lateral margin of the left foot ( Figure 1 and Figure 2).
Proteus syndrome: Biopsy from the cerebriform nevus of the foot.. Hematoxylin and eosin (magnification x100).
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A skin biopsy specimen from the left foot stained with hematoxylin and eosin revealed remarkable hyperkeratosis, epidermal hyperplasia, dermoepidermal fibrosis with extensive sclerosis of the reticular dermis, thickened collagen bundles, and fat-cell entrapment ( Figure 3).