PMC6129685_01
CT scan of chest showing a mediastinal mass.
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The rest of past medical history was unremarkable and she did not show any signs/symptoms of hypo or hyperthyroidism (Fig. 1, Fig. 2, Fig. 3, Fig. 4) . A CT scan of chest, abdomen and pelvis showed a 15*15 cm localized anterior mediastinal mass invading through the sternal bone in the center and protruding outward from the skin (Fig. 1).
Gross morphology showing a highly vascular soft mass.
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The specimen was sent for biopsy (See Fig. 2).
Post radiotherapy bone scan showing good iodine uptake.
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The rest of past medical history was unremarkable and she did not show any signs/symptoms of hypo or hyperthyroidism (Fig. 1, Fig. 2, Fig. 3, Fig. 4) . With a post therapy scan showing good uptake of therapeutic dose by post-operative residual functioning thyroid tissue over thyroid bed (See Fig. 3).
[A] Tumor infiltration into bone (arrows). (HnE stain;100x magnification) [B] Tumor infiltration into cartilage (arrows). (HnE stain;40x magnification) [C] Tumor infiltration into muscle fibers (arrows). (HnE stain; 400x magnification) [D] Tumor cells showing follicular arrangement and nuclei exhibiting enlargement, overlapping and clearing. (HnE stain;400x magnification).
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The biopsy of the thyroid specimen showed benign thyroid tissue, however, the mediastinal mass showed follicular variant of papillary thyroid cancer (See Fig. 4).