PMC8097161_01
Bone marrow aspirate smear (from bone marrow biopsy) stained with May-Grunwald Giemsa showing amastigote forms of Leishmania spp.
fimmu-12-669723-g001.jpg
PMC8097161_01_fimmu-12-669723-g001.jpg
f1
Finally, a bone marrow biopsy was performed showing hemophagocytosis, confirming HLH, and moreover, revealing the presence of Leishmania spp ( Figure 1 ), with a low parasitic load.
Viral load and CD4+ T-cells count evolution following cART initiation and VL diagnosis. TRIP = travel in Greece; H = date of hospitalization; (c)ART = (combined) anti-retroviral therapy; BMB = bone marrow biopsy (VL diagnosis); M1 = first month after cART initiation; M3 = third month after cART initiation; M6 = sixth month after cART initiation; LAmB = intravenous liposomal amphotericin B administrations.
fimmu-12-669723-g002.jpg
PMC8097161_01_fimmu-12-669723-g002.jpg
f2
VL was prescribed. Viral load decreased to 75 copies/mL and CD4+ T-cells count increased to 213/mm3 two months after cART initiation and viral load was undetectable with CD4+ T-cells count at 345/mm3 after 6 months ( Figure 2 ), with no sign of VL relapse.
PMC8097161_02