PMC7982992_01
Multimodal retinal imaging of Vogt-Koyanagi-Harada disease of both eyes at presentation. (a, b) Color fundus photograph shows multifocal subretinal detachments (SRD) involving the posterior pole of the right eye and the peripapillary area of both eyes. (c, d) Fluorescein angiography late frames show areas of pinpoint hyperfluorescent leaks of the retinal pigment epithelium with multifocal dye pooling underneath the SRD. (e, f) Indocyanine green angiography (ICGA) frames show persistent multiple hypofluorescent lesions, better seen in the late phases of the examination. (g) Enhanced-depth imaging optical coherence tomography (EDI-OCT) scan of the right eye shows increased subfoveal choroidal thickness (712 microm, white rhombus) and a bacillary detachment (white asterisk) associated with fibrin-like subretinal hyperreflective material (yellow arrow). (h) EDI-OCT of the left eye shows increased subfoveal choroidal thickness (750 microm, white rhombus) and extrafoveal subretinal accumulation of fluid (white asterisk). (i, j) OCT angiography of the choriocapillaris (4.5x4.5 mm) of both eyes shows multiple flow void spots (yellow arrowheads) at the posterior pole that correlate with the hypofluorescent lesions detected on ICGA.
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F1
Multimodal retinal imaging was performed (Figure 1 (Fig. 1)); FA showed multiple hyperfluorescent retinal pigment epithelium leaks in BE with dye pooling beneath SRD in the RE and normal retinal perfusion with no signs of vasculitis in either eye; ICGA showed persistent multiple hypofluorescent lesions in BE;
Multimodal non-invasive retinal imaging of Vogt-Koyanagi-Harada disease of both eyes 3 months after presentation. (a, b) Color fundus photograph shows resolution of the multifocal subretinal detachments in both eyes. (c, d) Fluorescein angiography shows residual mild retinal pigment epithelium changes in both eyes. (e, f) Indocyanine green angiography (ICGA) frames show remarkable decrease in size and number of the hypofluorescent lesions visible at presentation. (g, h) Enhanced-depth imaging optical coherence tomography (EDI-OCT) scan of both eyes show regression of the increased subfoveal choroidal thickness (538 microm in the right eye and 548 microm in the left eye) and resolution of the intra- and subretinal exudation. (i, j) OCT angiography of the choriocapillaris (4.5x4.5 mm) of both eyes shows an overall improvement of the choriocapillaris flow with remarkable decrease in size and number of the flow void spots detected at presentation.
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F2
ICGA showed marked reduction in size and number of the hypofluorescent lesions with correspondent decrease of the OCTA flow void spots detected at presentation (Figure 2 (Fig. 2)).