PMC5760679_01
High-resolution GTG banding showed a reciprocal balanced translocation t(2;11)(q33.2;q23.2) in the fetus.
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F1
Tehran, Iran in 2013. The result of amniocentesis showed a balanced translocation in fetus with no other findings in ultrasound scans (46, XX, t(2; 11) (q33; q23) (Figure 1).
FISH signals in metaphase and interphase from peripheral blood and a combination of two FISH-probes from split BACs (SB). The split BAC of chromosome 2q (RP11-1133F11) was red labeled and the split BAC of chromosome 11q (RP11-698I1) was green labeled. In normal chromatid, only one signal either green (on Chr. 2) or red (on Chr. 11) were detected. In chromatid with translocation, two signals (Red/Green) or their combination (yellow) was detected.
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PMC5760679_01_ijcn-12-094-g002.jpg
F2
RP11-158B3, Rp11-822K7, Rp11-984C17 and Rp11-2020 that hybridized with long arm of chromosome number 2. Rp11-69811signals was divided between long arm of chromosome number 2 and 11 (Figure 2).