PMC9170230_01
PMC9170230_02
PMC9170230_03
PMC9170230_04
Identification of individuals with SUPERNOVA phenotype and comparison of polygenic scores (PGS) for investigated patients and a control population of the same age and background. (A) Pulse wave velocity (PWV) measurements distribution in age-matched cohort of the Leningrad Siege survivors and two selected patients are highlighted; (B) PWV PGS, i.e., cfPWV; (C) High-density lipoproteins polygenic score.
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F1
Despite the presentation of SUPERNOVA in the two patients of interest, their PGS for cfPWV was not notable (Figure 1B), suggesting that the observed vessel stiffness could not be fully attributed to inherited risks. Next, we evaluated PGS for 11 clinical phenotypes that could potentially influence the supernova aging phenotype (Supplementary Figure 1). Both patients had PGS for HDL in the lower 5% of the populational distribution obtained from the matched control group (Figure 1C).