PMC5016813_01
Endoscopic images demonstrating multiple hyperpigmented lesions involving the cardia (A), umbilicated lesions in the body (B-C), and hyperpigmented lesions in the pylorus (D).
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In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1-2).
Endoscopic images demonstrating a solitary hyperpigmented lesion in the duodenum (A) and multiple hyperpigmented lesions involving the cardia and fundus (B-D).
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In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1-2).
H&E stained slide at 10x magnification demonstrating malignant cells with hyperchromatic nuclei and pink-to-purple cytoplasm infiltrating around benign gastric glands. Some pigment deposition can be seen within the cells of the malignant melanoma.
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Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3-4).
H&E stained slide at 40x magnification demonstrating the cells of the malignant melanoma infiltrating benign gastric glands. The nuclei of the melanoma are large, irregular, and hyperchromatic. Brown to black granular melanin pigment is seen associated with the cells of the melanoma.
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Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3-4).
Slide stained with an antibody to melanoma marker HMB45 at 10x magnification. The cells of the melanoma strongly express HMB45 as evidenced by brown cytoplasmic staining in the melanoma cells. The benign gastric glands are negative for HMB45.
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The cells expressed the melanoma marker HMB-45 on immunohistochemical stains, which were weakly positive for S-100 protein (Fig. 5).