PMC7754865_01
Fungating-polypoid mass with central ulceration at the fundus of the gallbladder.
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F1
The macroscopic examination of the piece showed tumoral lesion fundus/corpus localization and ulcerated surface (Fig. 1).
x40, H&E; tumor in a solid pattern.
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F2
x400, H&E; cells with hyperchromatic nucleus, indistinct nucleoli and narrow cytoplasm.
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F3
x200, synaptophysin; diffuse cytoplasmic positive reaction.
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F4
In immunohistochemical evaluation, cytoplasmic punctate linear positive staining for pan-cytokeratin in focal areas, diffuse cytoplasmic positive staining for synaptophysin and CD56, focal weak positive staining for chromogranin A (Fig. 4) were detected.
x200, The Ki- 67 proliferative index; 80-90%.
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F5
The Ki-67 proliferative index was 80-90% (Fig. 5).