PMC10189115_01
(A) Left fallopian tube invasive serous carcinoma (high-grade), bilateral ovaries, uterus, cervix, omentum, right fallopian tube, appendix, and dome margin with no tumor tissue (H&E staining, 200x). (B) Immunostaining for CA125 showing a positive reaction (200x). (C) Immunostaining for CR showing a positive reaction (200x). (D) Immunostaining for P53 showing a positive reaction (200x). (E) Immunostaining for WT1 showing a positive reaction (200x). (F) Immunostaining for CKL showing a positive reaction (200x). (G) Immunostaining for P16 showing a positive reaction (200x). (H) Immunostaining for CD10 showing a negative reaction (200x).
fonc-13-1079044-g001.jpg
PMC10189115_01_fonc-13-1079044-g001.jpg
f1
Histological examination of the resected specimen revealed a high-differentiated serous carcinoma of the left fallopian tube with serosa invasion ( Figures 1A-H ).
Abdominal computed tomography showing a low-density lesion in the low pole of the spleen with contrast enhancement during the arterial phase. (A) Arterial phase. (B) Venous phase.
fonc-13-1079044-g002.jpg
PMC10189115_01_fonc-13-1079044-g002.jpg
f2
The abdominal CT scan revealed a 4.0x3.0 cm low-density lesion in the spleen that was potentially malignant, with mild contrast enhancement during the arterial and no lymphadenectasis or distant metastasis ( Figures 2A, B ).
(A) Postoperative pathological result of the splenic lesion: serous carcinoma from the primary fallopian tube carcinoma (H&E staining, 200x). (B) Immunostaining for CA125 showing a positive reaction (200x). (C) Immunostaining for CK7 showing a positive reaction (200x). (D) Immunostaining for ER showing a positive reaction (200x). (E) Immunostaining for NapsinA showing a negative reaction (200x). (F) Immunostaining for Inhibin-alpha showing a negative reaction (200x). (G) Immunostaining for Vimentin showing a negative reaction (200x).
fonc-13-1079044-g003.jpg
PMC10189115_01_fonc-13-1079044-g003.jpg
f3
The histopathological diagnosis confirmed the splenic metastasis from PFTC ( Figure 3A ), supported by immunohistochemical stains positive for CA125, CK-7, and ER and negative for NapsinA, Inhibin-alpha, and Vimentin ( Figure 3B-G ).