PMC7485345_01
Identification of the p.Pro186Ala and p.Arg822Cys FGFR1 variants. (A) Schematic representation of the FGFR1 gene and protein. The p.Pro186Ala and p.Arg822Cys FGFR1 variants are indicated with arrows. (B) Multiple sequence alignment of the amino acids at position 186 (i) and 822 (ii) of the FGFR1 protein from various species. The conserved amino acids at positions 186 and 822 are indicated by red color. (C) The homology model of the FGFR1. (D) Design of the wildtype (i) and p.Pro186Ala mutant model (ii); the wildtype and p.Pro186Ala mutant models superposed (iii). (E) 2D interaction diagram for wildtype and p.Pro186Ala mutant models. (F) Conformational change induced upon variant. Wildtype is showing in green ribbon, while p.Pro186Ala mutant is showing in yellow ribbon.
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F5
Figure 5).