PMC3896667_01
PMC3896667_02
PMC3896667_03
PMC3896667_04
Circos plots for the 4 primary tumors and their matched metastases. Outer panels represent somatic SNVs with nonsynonymous and splice mutations in red, others are in black. Somatic copy number alterations are shown in inner panels (orange histogram, duplications; blue histogram, deletions). Structural variations are depicted as links in the interior of the plots. Blue link, inter-chromosomal translocations; red link, intra-chromosomal translocations; purple link, insertions; green link, deletions. Plots of A to H show the variants of primary tumor and metastasis from each of the 4 cases 441, D430, D473 and DD59 with "P" for primary and "M" for metastasis.
1755-8794-7-2-1.jpg
PMC3896667_04_1755-8794-7-2-1.jpg
F1
The patient is still undergoing periodic TACE for multiple HCCs at the time of this writing. The core information is marked with specific notes (Additional file 1: Table S1 and Additional file 2: Figure S1).