PMC5783106_01
VWF multimer analysis.. Note: Multimer analysis showed presence of low multimers but essentially near-complete absence of large and intermediate multimers, consistent with acquired type 2A VWD.. Abbreviations: VWF, von Willebrand factor; VWD, von Willebrand disease.
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Multimer analysis showed presence of low multimers but essentially near-complete absence of large and intermediate multimers, consistent with acquired type 2A VWD (Figure 1).
Clinical pharmacokinetics of VWF and FVIII before and after surgery.. Notes: VWF activity (VWF:Ab) and FVIII levels improved with IVIG infusion but were <80% preoperatively. With a bolus infusion of Humate-P , both VWF:Ab and FVIII levels improved to >100% and remained stable for ~3 days after the thyroidectomy. The patient did not have any intra- or postoperative bleeding and recovered well from surgery.. Abbreviations: VWF, von Willebrand factor; FVIII, factor VIII; IVIG, intravenous immunoglobulin.
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Daily plasma VWF:Ab and FVIII levels were checked for 3 days postoperatively, with levels remaining >100% (Figure 2).