PMC4369643_01
Brain magnetic resonance imaging. (A) Photograph of the patient aged 5 years demonstrating left convergent squint and normal facial appearance. (B) Axial T2-weighted image at 29 months, revealing enlarged lateral ventricles. (C) Coronal T2-FLAIR image at 29 months, displaying abnormal white matter signal in a periventricular distribution. (D) Midsagittal T1-FLAIR image at 29 months, showing thinning of the corpus callosum with enlarged subarachnoid spaces. (E) Coronal T2-FLAIR image at 5 years 6 months, showing abnormal periatrial signal and enlarged lateral ventricles. (F) Axial 3D FSPGR image at 5 years 6 months, displaying abnormal signal in the posterolateral region of the putamen nucleus.
fgene-06-00102-g0001.jpg
PMC4369643_02_fgene-06-00102-g0001.jpg
F1
However, despite her apparent clinical stability, there is some neuroradiological evidence that her condition continues to be slowly progressive (Figures 1E-F).
PMC4369643_02
Brain magnetic resonance imaging. (A) Photograph of the patient aged 5 years demonstrating left convergent squint and normal facial appearance. (B) Axial T2-weighted image at 29 months, revealing enlarged lateral ventricles. (C) Coronal T2-FLAIR image at 29 months, displaying abnormal white matter signal in a periventricular distribution. (D) Midsagittal T1-FLAIR image at 29 months, showing thinning of the corpus callosum with enlarged subarachnoid spaces. (E) Coronal T2-FLAIR image at 5 years 6 months, showing abnormal periatrial signal and enlarged lateral ventricles. (F) Axial 3D FSPGR image at 5 years 6 months, displaying abnormal signal in the posterolateral region of the putamen nucleus.
fgene-06-00102-g0001.jpg
PMC4369643_02_fgene-06-00102-g0001.jpg
F1
However, despite her apparent clinical stability, there is some neuroradiological evidence that her condition continues to be slowly progressive (Figures 1E-F).