PMC5702189_01
Microscopic appearance: the tumor is composed of compact nests and sheets of epithelial cells surrounded by a prominent component of mature lymphocytes and plasma cells. Hematoxylin and eosin stain; original magnification x100
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Fig1
Laryngeal biopsy was performed and revealed, on microscopic examination, a malignant tumor composed of solid sheets disposed in lymphoid background (Fig. 1).
Microscopic appearance: tumor cells are undifferentiated, large, with round, vesicular nuclei, containing a prominent nucleolus, and with an abundant, ill defined cytoplasm. Hematoxylin and eosin stain; original magnification x400
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Fig2
The cytoplasm was poorly limited (Fig. 2).
positive immunohistochemical staining for cytokeratin 5/6
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Fig3
Automated immunohistochemistry showed positivity for Cytokeratin 5/6 (D5/16B4) (Fig. 3).