PMC7574905_01
Case showing progression of NVE over time. Left images were obtained in an early disease stage. OCTA en face image (A, top) showing a small temporal NVE within the dashed circle. Corresponding OCT B-scan with flow overlay (A, bottom) shows a flat NVE with breaching of the ILM and flow signal (located within the dashed circle). Follow-up OCTA images revealed the same features in the en face OCTA, (B, top; NVE located within the dashed circle) while the corresponding OCT B-scan (B, bottom) revealed NVE progression (situated within the dashed circle), with ILM breaching and new protrusion.
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A 49-year-old male patient with type 1 DM presented with active PDR in the right eye with NVE, identified in OCTA as multiple filamentous irregular new vessel flow signals localized in the temporal retina (Figure 7A). At 11 months follow-up, OCTA (Figure 7B) showed the same features while the corresponding B-scan with flow overlay revealed disease progression with protrusion of the complex.
PMC7574905_02
OCT angiograms of PDR treated with laser photocoagulation. Left column: (A, top) Baseline en face OCTA showed the presence of NVD with multiple irregular and looped new vessels (located within the dashed circle). (A, bottom) Co-registered OCT B-scan with flow overlay revealed the NVD protruding from the disc and the presence of flow signal within the complex. (B) Same patient OCTA after PRP treatment - the en face image (top) showed significant regression of the NVD (within the dashed circle) and the B-scan with flow overlay (bottom) demonstrated less flow signal, consistent with regressing NVD.
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PDR in the right eye with NVD, identified as looped and irregular flow signals within the temporal half of the disc (Figure 8A) indicating disease activity. Panretinal photocoagulation was performed and at 3-months follow-up, same location OCTA (Figure 8B) showed significant NVD flow signal regression with fewer pruned vascular signals.