PMC6317838_01
(A) Hematoxylin and eosin (H&E) stain of portal tract (x200) with mild duct injury (arrow), cholangiolar cholestasis, and ductal reaction. (B) H&E stain (x400) showing extensive mixed inflammation including leukocytes. (C) Trichrome stain (x200) showing mild periportal fibrosis.
CG-CGCR180078F001.jpg
PMC6317838_01_CG-CGCR180078F001.jpg
F1
Liver biopsy revealed marked ductal reaction and mild focal cholestasis suggestive of biliary obstruction (Figure 1).
(A) Hematoxylin and eosin (H&E) stain (x200) showing more advanced cholestasis, mixed inflammation, and loss of bile ducts. (B) H&E stain (x400) showing senescent-type degenerative changes in bile ducts. (C) Cytokeratin 7 immunohistochemical stain (x20) showing extensive ductular reaction.
CG-CGCR180078F002.jpg
PMC6317838_01_CG-CGCR180078F002.jpg
F2
Progressive ductopenia was seen in 15 of 22 portal tracts, in addition to increased portal expansion and fibrosis (Figure 2).