PMC4904146_01
Post-traumatic wound before the treatment
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F1
The initial depth of the wound was 4 cm and width was 3.6 cm (Figure 1).
Radiographic examination: multi-fragmented fracture of distal end of tibia and also a fracture of fibula, well as numerous radiopaque foreign bodies
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F2
The radiographic examination showed a multi-fragmented fracture of distal end of tibia and also a fracture of fibula, well as numerous radiopaque foreign bodies (Figure 2). 
Intra-operatory view. PRP gel application
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F3
PRP was obtained. PRP obtained is a high quality PRP with the highest platelet recovery and highest growth factors contents as described before., PRP activated with autologous thrombin may be injected intra-lesional and perilesional or forming platelet gel and used topically (Figure 3).
Intra-operatory view. Application of HA on PRP
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F4
In combination with the platelet gel, the wound was covered with a three-dimensional polymerized hyaluronic acid medicated biologic dressing (Figure 4).
Postoperative view after 45 days: A: anterior view, B: antero-medial view
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F5
Forty-five days after the surgical treatment there was full recovery (Figure 5).
Postoperative view after 8 weeks
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F6
The postoperative course was uneventful and the early postoperative result was very satisfying for both the surgeon and the patient (Figure 6).