PMC5856665_01
From October 2013, the patient became progressively neutropenic during monthly cycles of 5-azacytidne. By January 2014, the AML had relapsed. After 2 cycles of microtransplantation, the patient demonstrated resolution of chronic, severe neutropenia. However, there were no major changes in platelet and lymphocyte counts after relapse despite microtransplantations.
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After five monthly cycles the patient became increasingly neutropenic with an absolute neutrophil count (ANC) declining from 900 to 100 (Fig. 1).
PMC5856665_02
The x-axis represents the number of days that elapsed from the first microtransplant infusion. The second infusion of stem cells occurred on Day+33.
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ANC continued to accelerate to 1500 by day 70 (Fig. 2). A surveillance bone marrow biopsy on day 95 confirmed the persistency of remission.