PMC5004027_01
Light microscopy shows monomorphous round cells with salt-and-pepper chromatin arranged mostly in nests with a cribriform pattern that formed rosette-like structures (hematoxylin and eosin stain, original magnification x20).
CRIOT2016-6971491.001.jpg
PMC5004027_01_CRIOT2016-6971491.001.jpg
fig1
It showed monomorphous round cells with salt-and-pepper chromatin arranged mostly in nests with a solid or cribriform pattern that formed frequent rosette-like structures (Figure 1).
Further immunohistochemical analysis shows strong positive staining for CD56 (original magnification x20).
CRIOT2016-6971491.002.jpg
PMC5004027_01_CRIOT2016-6971491.002.jpg
fig2
CD56 (Figure 2). CK AE1/AE3 was also positive.