PMC9277061_01
Subject of this study. (A) Subject inclusion, (B) Family pedigree, and (C) Subject characteristics.
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F1
The clinical features of all three subjects are summarized in (Figure 1C).
MRI images of SCA3 patients compared to a normal subject. (A) Sagittal view. (B,F) Coronal view. (C-E) Axial view. Red arrow: lateral ventricle (dilated in SCA3); green arrow: fourth ventricle (dilated in SCA3); yellow arrow: brainstem (size reduced in SCA3); orange arrowhead: cerebellum (size reduced in SCA3).
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F2
Qualitatively, we compared MRI brain images from SCA3 subjects (Subjects 1-3) and a unaffected subject (Subject 7) (Figure 2).