PMC7568163_01
Our patient's initial chest CT scan showing scattered ground glass opacities bilaterally (red circle).
CRIONM2020-8048056.001.jpg
PMC7568163_01_CRIONM2020-8048056.001.jpg
fig1
Computerized tomography (CT) of the chest revealed scattered ground glass opacities bilaterally (Figure 1).
Follow-up chest CT scan showing an 8 mm left lower lobe pulmonary nodule (red arrow) which appeared to be enlarging.
CRIONM2020-8048056.002.jpg
PMC7568163_01_CRIONM2020-8048056.002.jpg
fig2
On her latest CT scan of the chest, there was an 8 mm left lower lobe pulmonary nodule which appeared to be enlarging (Figure 2).
Hematoxylin and eosin stain of transthoracic needle lung biopsy. This slide is at 40x magnification. The sections show multiple cores of lung parenchyma, some of which contain an intra-alveolar infiltrate of relatively monomorphic tumor cells with round nuclei and a moderate eosinophilic cytoplasm. The cells are set in a myxohyaline stroma. Scattered areas show intracytoplasmic lumina, and there are also intranuclear inclusions. Most of the tumor appears to be intra-alveolar and the surrounding lung parenchyma shows mildly prominent type II pneumocytes. There is no evidence of significant nuclear atypia, mitoses, or necrosis.
CRIONM2020-8048056.003.jpg
PMC7568163_01_CRIONM2020-8048056.003.jpg
fig3
TTF-1, Pax-8, CAM 5.2, EMA, CDX2, CK20, and CK7 were negative in the tumor cells. The findings fit with a low-grade epithelioid hemangioendothelioma (Figures 3, 4, and 5).
Immunohistochemical stain showing uptake of CD31.
CRIONM2020-8048056.004.jpg
PMC7568163_01_CRIONM2020-8048056.004.jpg
fig4
TTF-1, Pax-8, CAM 5.2, EMA, CDX2, CK20, and CK7 were negative in the tumor cells. The findings fit with a low-grade epithelioid hemangioendothelioma (Figures 3, 4, and 5).
Immunohistochemical stain showing uptake of ERG.
CRIONM2020-8048056.005.jpg
PMC7568163_01_CRIONM2020-8048056.005.jpg
fig5
TTF-1, Pax-8, CAM 5.2, EMA, CDX2, CK20, and CK7 were negative in the tumor cells. The findings fit with a low-grade epithelioid hemangioendothelioma (Figures 3, 4, and 5).