PMC7550933_01
PMC7550933_02
Mechanism of ticagrelor-related dyspnoea - adenosine
hypothesis.
10.1177_1179547620956634-fig1.jpg
PMC7550933_02_10.1177_1179547620956634-fig1.jpg
fig1-1179547620956634
A1R and A2AR and finally causes the sensation of dyspnoea. As adenosine induces bronchial smooth muscle cells contraction and increases the release of broncho-constrictive mediators from other cells expressing ARs, it is also possible, that ticagrelor-related dyspnoea may be the result of severe bronchospasm (Figure 1).
Mechanism of ticagrelor-related dyspnoea - P2Y12 receptors
hypothesis.
10.1177_1179547620956634-fig2.jpg
PMC7550933_02_10.1177_1179547620956634-fig2.jpg
fig2-1179547620956634
The gial cells have potential to stimulate the central chemoreflex system and to elicit Cheyne-Stokes respiration (Figure 2).