PMC9969431_01
Left adnexal mass measuring about 4 x 4.2 cm on computed tomography of the
abdomen and pelvis.
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Computed tomography of the abdomen done showed fatty liver, hepatomegaly, and a left heterogeneous ovarian mass measuring 4 x 4.2 cm (Figure 1) and an enlarged left adrenal gland measuring 1.5 x 2 cm.
Hematoxylin & eosin-stained section of the ovarian mass showing a diffuse
proliferation of large somewhat pleomorphic cells. Photographed at 20x
magnification.
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Her pathology showed that the left ovary displayed near-complete replacement by a diffuse proliferation of large somewhat pleomorphic cells (Figure 2), with prominent nucleoli (Figure 3), numerous mitotic figures, admixed body macrophages, and punctate areas of necrosis.
Hematoxylin & eosin-stained section of the ovarian mass photographed at
40x magnification showing the irregular nuclear contours and prominent
nucleoli.
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Her pathology showed that the left ovary displayed near-complete replacement by a diffuse proliferation of large somewhat pleomorphic cells (Figure 2), with prominent nucleoli (Figure 3), numerous mitotic figures, admixed body macrophages, and punctate areas of necrosis.
Ovarian mass photographed at 20x magnification stained with Ki-67
immunohistochemistry showing the high proliferation index with >90% of
the cells staining positive (brown = positive).
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Immunohistochemistry showed the malignant cells expressed PAX5, CD20, MYC (Figure 4), and BCL2 (weak 30%).
Ovarian mass photographed at 20x magnification stained with MYC
immunohistochemistry showing expression in about 50% of the cells (brown =
positive).
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Her Ki-67 proliferation index was greater than 90% (Figure 5).