PMC8725728_01
(a) The patient presented with diffuse erythema and dried-up lakes of pus on the back. (b-d) Pinpoint pustules and erythema multiforme-like lesions were diffusely spread over the upper arms and palms (pinpoint pustules, yellow arrowhead; target lesions, green arrowhead). (h,i) Biopsy results demonstrated subcorneal pustules, spongiosis as well as lymphocyte and eosinophils infiltration in the dermis. (e-g) All pustules faded 3 days later and erythema substantially darkened.
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F1
Pustules and erythema multiforme-like lesions were diffusely spread over the upper arms and palms (Figures 1a-d). The result demonstrated subcorneal pustules, spongiosis as well as lymphocyte and eosinophils infiltration in the dermis (Figures 1h,i). After the first therapy of secukinumab, all pustules faded at day 3, and erythema substantially darkened with defervescence (Figures 1e-g).