PMC9338697_01
A) ultrasound image of the right breast: nodule with heterogenous echostructure (yellow asterisk); B) gross examination of the two adjacent tumors: spongy and hemorrhagic well-defined tumor (yellow arrow) adjacent to a second grayish-white and irregular tumor (black arrow); C) angiosarcomatous proliferation: anastomosing and irregular vessels with intraluminal tufting (HEx200); D) area of invasive carcinoma of no special type: cords and glandular structures composed of atypical cells (HEx200)
PAMJ-42-70-g001.jpg
PMC9338697_01_PAMJ-42-70-g001.jpg
F1
Diagnostic assessment: ultrasound examination disclosed a nodule with heterogeneous echostructure measuring 9.2 cm (Figure 1A). At gross examination, there was a spongy and hemorrhagic tumor measuring 8.5 cm, in contact with a second grayish-white tumor measuring 3 cm (Figure 1B). Microscopically, the spongy tumor showed findings consistent with high grade (HG) PBAS (Figure 1C). Tumor cells were cuboidal with hyperchromatic and voluminous nuclei (Figure 1D).
histological feature of the two adjacent tumors: angiosarcomatous proliferation (yellow asterisk) in contact with an invasive carcinoma (black asterisk) without histological admixture: A) low magnification (HEx100); B) high magnification (HEx200); C) CD31 immunohistochemical study: vascular proliferation positive for CD31 (x400); D) progesterone receptor immunohistochemical study: carcinomatous proliferation positive for progesterone receptor (black asterisk); vascular proliferation negative for progesterone receptor (yellow asterisk) (x100)
PAMJ-42-70-g002.jpg
PMC9338697_01_PAMJ-42-70-g002.jpg
F2
No images of intermingled epithelial and vascular proliferations were seen (Figure 2 (A,B)). Ki-67 was 10% (Figure 2 (C,D)).