PMC4246698_01
Computed tomography scan revealing two circular low density areas with clear boundaries. Circular, radiative, enhanced signals were observed at the margin of the tumor mass.
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Computed tomography (CT) scanning revealed two tumor masses in the lower lobe of the splenic parenchyma, with the larger one measuring 5.6 x 5.9 x 6.3 cm (Fig. 1).
Primary hemangioendotheliomas of the spleen. (A) Two tumor masses, growing exogenously, were observed at the lower spleen pole. (B) The sizes of the tumor masses were 6.0 x 6.0 x 5.5 cm and 5.0 x 5.0 x 4.0 cm. The texture of the tumor mass was soft with a gray color in the center of the incisal surface.
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Upon further observation, two tumor masses, growing in an exogenous pattern, were observed at the lower spleen pole, measuring 6.0 x 6.0 x 5.5 cm and 5.0 x 5.0 x 4.0 cm (Fig. 2).
Stained sections of the tumors. (A) Hematoxylin and eosin staining indicated dispersed hyperplasia of vascular endothelial cells invading into the lumen (magnification, x100). (B) Immunohistochemical analysis revealed that the tumor cells were positive for FVIII (magnification, 200x).
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Pathological examination indicated that the tumor masses primarily consisted of capillaries and well-differentiated great vessels (Fig. 3).