PMC10241630_01
(a)Contrast MRI: multifocal patchy enhancing soft tissue lesion involving lower dorsal cord, conus and cauda equina from D10 to L4. (b) Section from the viable area showing abrupt transition between glial tissue and cellular tumour zones (H and E, 100x). (c) Tumour showing large pleomorphic cells arranged in diffuse infiltrating pattern with angiocentricity (inset) with enlarged nuclei and scanty cytoplasm, with prominent nucleoli. (H and E, 400x). (d-f) Immunohistochemistry showing diffuse strong membranous positivity for CD20 (d), scattered positivity for CD3(e) and high Ki-67 labelling (f) (400x)
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On contrast MRI, multifocal patchy enhancing soft tissue lesion involving lower dorsal cord, conus and cauda equina from D10 to L4 level associated with diffuse spinal cord signal changes and syrinx formation from lower border of D10 upto conus was seen [Figure 1a]. Excised tumour biopsy revealed multiple bits of necrotic tissue with viable areas showing abrupt transition between glial tissue and highly cellular zones [Figure 1b and c]. Immunohistochemistry showed diffuse positivity for CD 20 in the large tumour cells, scattered CD3 positive reactive lymphoid cells and more than 80% Ki-67 staining [Figure 1d-f].