PMC4782656_01
Hyperkeratotic erythematous tumor with areas of ulceration in right lower
limb
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Dermatological examination revealed a 3.2 cm x 2.8 cm hyperkeratotic ulcerated tumor in the posterolateral view of the right lower limb (Figure 1).
Magnetic resonance imaging of the ankle showing expansive lesion with
defined boundaries centered in the subcutaneous plane
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Imaging tests showed that the tumor was located above the muscle fascia; no lymph node or distant metastasis were detected (Figure 2).
Intermediate grade myxofibrosarcoma. (A) Transition between myxoid area
and cellular area. (HE, 100X). (B) Atypical cells with scant cytoplasm
(HE, 400X).
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The surgical resection was performed with a 2 cm margin and the histopathology showed proliferation of ovoid or spindle cells arranged in bundles, with irregular, hyperchromatic nuclei and mitotic figures, combined with myxoid stroma (Figure 3).
Myxofibrosarcoma revealing elongated, curvilinear, thin-walled blood
vessel (HE, 400x)
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The presence of elongated, curvilinear, thin-walled blood vessels was also noticed (Figure 4).