PMC7086435_01
CT angiogram of neck ((a) coronal, (b) axial) demonstrating a 3.5 cm heterogeneous lesion in the posterior wall of the hypopharynx in a submucosal location (i) and a smaller 1.7 cm lesion of the right posterior wall of the hypopharynx (ii). The mass caused severe narrowing of the air column at the hypopharynx (iii).
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fig1
A CT scan of the neck (Figure 1) showed a 3.5 cm in diameter hyperdense mass in the hypopharynx originating in the left dorsal wall and a smaller 1.7 cm mass in the right posterior hypopharynx.
(a) Dedifferentiated liposarcoma, solid fascicles of spindle cells with eosinophilic cytoplasm and slightly enlarged nuclei; (b) well-differentiated area, adipocytes, and lipoblasts with enlarged, hyperchromatic nuclei and multivacuolated cytoplasm (hematoxylin and eosin, 200x magnification).
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fig2
On microscopic examination, the neoplasm was predominantly composed of dedifferentiated areas with solid sheets of spindle cells in a fascicular and storiform pattern (Figure 2(a)). There was a minor component of well-differentiated soft tissue, from which the dedifferentiated liposarcoma likely arose, composed of adipocytes and atypical lipoblasts with enlarged, hyperchromatic nuclei with multivacuolated cytoplasm (Figure 2(b)).