PMC9377508_01
Timeline of relevant events in the patient history.
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A timeline of the patient's course is available in Figure 1.
Harris Lines are visible as radiopaque transverse lines located in the metaphyses of the long bones (femur and tibia in this picture). These lines are the result of growth arrest periods, but can also be seen in cases of heavy metal intoxication.
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Harris lines in the metaphyses of the femur, tibia, and fibula; see Figure 2. Harris lines on the X ray and edema on metaphyseal bones can reflect growth arrest lines.
Edema of metaphyseal areas is visible in the T1 sequence as hypointense signals in the affected areas.
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Whole-body MRI (WBMRI) revealed metaphyseal edema of the long bones (elbows excluded), pubic arches, and sacroiliac joints (Figures 3, 4).
Hyperintense signals are present in the T2 MRI sequence in metaphyseal areas, compatible with metaphyseal edema of long bones.
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Whole-body MRI (WBMRI) revealed metaphyseal edema of the long bones (elbows excluded), pubic arches, and sacroiliac joints (Figures 3, 4). Signal abnormalities of metaphyseal areas in the MRI were highlighted by our radiologists and were suggestive for a metabolic disease or a hematological condition (Figure 4).