PMC3656690_01
a Skin lesions in patient 1 which consisted of maculopapular rash with ulcerations and edema at lower leg and foot before treament. b After treatment with rituximab.
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F1
Lower extremities showed bilateral maculopapular rash with ulcerations and livida reticularis (fig. 1).
Photomicrograph of a section of skin in patient 1, showing dilated subepidermal small vessels with swollen endothelial cells. There is a perivascular infiltrate consisting mainly of lymphocytes, few plasma cells and extravasated erythrocytes of which some are fragmented. No vascular necrosis is seen (HE, x200).
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F2
Skin biopsy showed leukocytoclastic vasculitis with predominantly lymphocytic infiltrate in the subepidermal layer only with extravasated fragmented erythrocytes indicating vascular leaks (fig. 2).
PMC3656690_02