PMC8417936_01
Irregular, inhomogeneous, solid soft-tissue mass, with a diameter of 90 mm, sited in the root of mesentery (arrows), in contact with the small bowel, shown from three different orientations (A-C).
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F1
An oval-shaped mass measuring 8.5 x 8 x 6.5 cm, with evidence of a pseudo-capsule and locoregional lymph nodes of increased volume, were observed in the mesentery (Figure 1).
The mesenteric mass was composed of a proliferation of bland-looking spindle cells with slightly eosinophilic cytoplasm and elongated normochromatic nuclei with mild nuclear atypia, haphazardly set in a collagenized stroma [(A,B) (Arrow), H&E, 20x]. The myofibroblastic nature of the lesional spindle-shaped cells was confirmed by the expression of Smooth Muscle Actin [(C) (Arrow), 20x] and Vimentin [(D) (Arrow), 20x].
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F2
Immunohistochemical analyses, showing a diffuse staining for vimentin and smooth muscle actin, revealed the myofibroblastic nature of the lesional spindle-shaped cells (Figure 2).