PMC9715734_01
Ulcerated and bleeding colonic mucosa with petechial hemorrhages.
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F1
Fragile colonic mucosa with petechial hemorrhages.
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F2
Bleeding colonic mucosa.
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F3
Histological examination of colonic biopsies: active colitis, with mucosal microerosions.. (asterisks), a moderate inflammatory infiltrate in the lamina propria, including lymphocytes, plasmacells, and neutrophils (arrows), and an associated multifocal cryptitis, defined by the presence of intraepithelial neutrophils in colonic crypts (arrowheads in the box).
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F4
Panniculitis of the lower limbs.
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F5
On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
Panniculitis of the upper limbs.
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F6
On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
Ulcerative lesion of the hand.
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F7
On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
Necrotic lesion of the foot.
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F8
On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
PMC9715734_02
Family tree.
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F9
TNFAIP3. The other family members in the paternal line presented potential clinical conditions of HA20 but could not be screened for mutations (Figure 9).