PMC7754096_01
A tumor measuring 30 x 40 mm in diameter was identified in the anterior wall of the gastric corpus.
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A 40-mm ulcerative lesion within the gastric antrum on the posterior wall of the lower body was identified by esophagogastroduodenoscopy (EGD), the surface of the lesion was irregular, erosive, and reddish (Figure 1).
Thickening of the gastric wall (arrowhead), high density of fat around the gastric wall, and the "station 3" enlarged lymph node.
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Contrast-enhanced abdominal computed tomography (CT) and Positron Emission Tomography-Computed Tomography (PET-CT) showed a mass in the mid-portion of the stomach with marked thickening of the gastric wall (Figures 2 and 3).
Positron emission tomography/computed tomography revealed uptake by the gastric wall and perigastric lymphadenopathy.
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Contrast-enhanced abdominal computed tomography (CT) and Positron Emission Tomography-Computed Tomography (PET-CT) showed a mass in the mid-portion of the stomach with marked thickening of the gastric wall (Figures 2 and 3).
(A) Histopathological findings: Hematoxylin-and-eosin staining of the tumor. (B) On immunohistochemical study, the tumor cells were positive for CD34.
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IHC report, even our experienced pathologist was uncomfortable with a gastric angiosarcoma diagnosis due to its low probability of occurrence. In the immunohistochemical study, the tumor cells were positive for vimentin and CD34, focally positive for cytokeratin (AE1/AE3), and negative for CD117 (Figure 4A and B).
Remarkable shrinkage in tumor size was observed, improvement of gastric wall thickness after chemotherapy and shrinkage of lymphadenopathy after chemotherapy (arrowhead).
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MDT (Figures 5 and 6). Moreover, clinical symptoms were relieved.
After three cycles of chemotherapy, remarkable shrinkage in tumor size was observed.
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MDT (Figures 5 and 6). Moreover, clinical symptoms were relieved.
The resected gastric tissue specimen of the angiosarcoma regressed.
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Surgical specimens were assessed to complete the pathological response (Figure 7), the tumor was resected with negative margins and 0/42 lymph nodes being positive for metastatic disease.
Multiple metastases of liver and retroperitoneal region after the surgery.
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Contrast-enhanced abdominal CT showed multiple metastases of liver and retroperitoneal region (Figure 8).