PMC3335480_01
Extraoral examination revealed diffuse enlargement of lower right side of face over the angle and body of mandible.
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fig1
She complained of a painful swelling in the right side of mouth (Figure 1).
Ulceroproliferative growth seen on lower right posterior third molar area.
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fig2
The lesion was soft to firm and measured about 4 cm x 3 cm (Figure 2).
Lateral oblique:osteolytic lesion in nos. 46, 47, 48 regions. S/o destructive bony lesion.
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fig3
 Radiological examinations with lateral oblique radiograph (Figure 3) showed osteolytic areas with ill-defined borders located in the right mandibular angle and ramus.
Photomicrograph showing high cellularity, intense proliferation of spindle-shaped cells and variable deposition of collagen (10x view).
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fig4
An incisional biopsy was performed, and on microscopic examination fascicles of spindle-shaped cell with areas of collagen fibers were observed (Figure 4).
Spindle shaped cell showing nuclear pleomorphism (40x).
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The cells exhibited hyperchromatic nuclei and increased nuclear cytoplasmic ratio (Figure 5).
Neoplastic cells displaying intense immunoreactivity for vimentin (40x).
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fig6
Further, immunohistochemistry analysis showed a positive reaction for vimentin (Figure 6), but not for S-100 protein, cytokeratin cocktail, HMB-45, Desmin, smooth muscle actin, and epithelial membrane antigen (EMA).