PMC5752214_01
A Axial T2- weighted TIRM MR sequence shows homogeneous hyperintense irregular mass. B, on early phase image of dynamic enhancement MRI, tumor shows irregular shape and irregular margin with heterogeneous enhancement is seen.
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In our institution, an MRI showed a homogenous hyper-intense irregular mass with indistinct margins; on early phase image of dynamic enhancement the tumor showed an irregular shape, irregular margins and heterogeneous enhancement (Fig. 1).
Core biopsy (A) On panoramic view the tumor is composed of multiple groups of neoplastic cells immerse on extracellular mucin (hematoxylin-eosin). (B) Extracellular mucin lakes with are the prominent characteristic of the tumor. (C) ER was positive with 100% of neoplastic cells (D) PR was positive in the 100% of the cells. (E) Her2-neu (3+) 100% of the neoplastic cells.
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Revision of core biopsy's slides was reported as a grade 1 carcinoma with mucinous features, 100% positivity for estrogen receptors with high intensity, 90% for progesterone receptors with high intensity and 100% positivity for HER 2 (3+) (Fig. 2).
Surgical resection (A) Panoramic view of the tumor is composed of multiple groups of neoplastic cells immerse on extracellular mucin (hematoxylin-eosin 4x). (B) Extracellular mucin lakes with are the prominent characteristic of the tumor (40x). (C) ER was positive with 100% of neoplastic cells (D) PR was positive in the 100% of the cells. (E) Her2-neu (3 + ) 100% of the neoplastic cells. Pathologic no response (pNR).
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Immunohistochemistry was performed and the results were: 100% positivity for estrogen receptors with high intensity, 90% for progesterone receptors with high intensity and 100% positivity for HER2 (3 + ) (Fig. 3). With all of this, it was classified as ypT2N0Mx (Fig. 3).