PMC4748787_01
a Glomeruli are mildly hypercellular. Occasional mild cellular infiltration is noted near the vas afferens (arrow). Hematoxylin and eosin stain, original magnification x200. b A representative glomerulus shows mild to moderate endocapillary hypercellularity, mainly mononuclear cells. A mitotic figure of apparent endothelial cell is observed (arrow). Periodic acid-Schiff stain, original magnification x400. c The same glomerulus as in b. Mesangial matrix is not increased and segmental mesangiolysis (arrow) is noted. Periodic acid-methenamine-silver stain, original magnification x400. d Mitotic figures of the tubular epithelial cells (arrows) were observed. Hematoxylin and eosin stain, original magnification x400. e An apoptotic body (arrow) was also observed in a tubule. Hematoxylin and eosin stain, original magnification x400.
cnd-0006-0014-g01.jpg
PMC4748787_01_cnd-0006-0014-g01.jpg
F1
The patient's renal biopsy showed mild endocapillary hypercellularity, mainly of mononuclear cells, with several neutrophilic leukocytes (fig. 1a). Mesangial matrix was not increased and segmental mesangiolytic changes were observed (fig. 1c).
By a immunofluorescent study, IgG (a) and C3 (b) depositions were seen mainly along the capillary walls and less in the mesangium.
cnd-0006-0014-g02.jpg
PMC4748787_01_cnd-0006-0014-g02.jpg
F2
By immunofluorescent study, prominent fine granular IgG (2+) and weakly positive C3 (1+) deposits were found along the capillary walls and in the mesangium (fig. 2), but IgA, IgM, C4, and C1q deposits were very modest in the same pattern.
There were many relatively small subepithelial electron-dense deposits without spikes (s. ep); most of them were separated from the lamina densa by the lamina rara; a few subendothelial (s. en), intramembranous (In. m) and mesangial deposits (mes) were also observed.
cnd-0006-0014-g03.jpg
PMC4748787_01_cnd-0006-0014-g03.jpg
F3
A few subendothelial, intramembranous and mesangial deposits were also observed (fig. 3).