PMC3785368_01
Evolution of lung computed tomography scan from patient 1. A) Eighty four days after cord blood transplantation, the scan showed a right hilar mass together with an atelectasis of the right upper lobe leading to the diagnosis of endobronchial post transplant lymphoproliferative disorder. B) Five months later, while the patient had received 3 courses of rituximab and cytotoxic chemotherapy, the scan was normalized.
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The chest radiograph and the CT scan showed a right hilar mass with atelectasis of the right upper bronchus (Fig. 1). The right apical pulmonary abnormalities resolved both on the lung CT scan and bronchoscopy (Fig. 1).
Histological findings of a bronchial biopsy from patient 1: A) and B) The bronchial lamina propria is infiltrated by polymorphic tumoral lymphoid cells (Hematoxylin eosin safran x 100, x 400). C) Immunohistochemical study shows a positive reaction for the B cell marker CD79a in the tumoral cells (x 400). D) In situ hybridization with EBERs probes shows that virtually all the tumoral cells are infected by the Epstein Barr virus (x 400).
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In situ hybridization of EBV-encoded RNA (EBER) was positive (Fig. 2).
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