PMC6557745_01
Clinical course. . A 77-year-old man experienced severe thrombocytopenia (0.2 x 104/mcl) on day 15 after 240 mg of first nivolumab administration. Daily administration of 60 mg of prednisolone started from on day 17 restored the patient's platelet count. Despite of prednisolone tapering, the platelet count could keep >10 x 104/mcl on and after day 71. Subsequent nivolumab treatment was discontinued and provided best supportive care. Shown are the changes in platelet number and CRP concentration throughout the treatment period.
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The patient showed progress after 6 cycles of nab-paclitaxel and carboplatin, and was given single-agent nivolumab (240 mg/body, every 2 weeks) as second line therapy (Fig. 1).
On day 29 after a single cycle of nivolumab administration, thoracic CT revealed significant shrinkage of the primary lesion, and stable disease was achieved. Thoracic CT before treatment (Left) and after one cycle of nivolumab (Right).
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On day 29 after initiating nivolumab administration, thoracic CT revealed significant shrinkage of the primary lesion, and stable disease was achieved (Fig. 2).