PMC5308427_01
Leukemia cutis as bilateral helical lesion before and after chemotherapy.
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A 45-year-old male, with no significant past medical history, noted skin changes involving both ears about 3 years prior to initial presentation (Figure 1). The skin lesions regressed (Figure 1) and the lymphadenopathy resolved.
(a) Histopathology demonstrating dense mononuclear cell infiltrate (hematoxylin and eosin; 10x), (b) immunohistochemical (IHC) stains strongly and diffusely positive for CD20, (c) IHC stain positive for CD5; 40x and (d) IHC stain positive for CD23; 40x.
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Biopsies (Figure 2) of these skin lesions were performed and results were suggestive of a low-grade B-cell lymphoma (initial immunohistochemical (IHC) stain positive for CD20, few positive for CD3 and negative for CD30).