PMC2843900_01
MRI findings in two cases of immunotherapy responsive autoimmune subacute encephalitis. Brain MRI of Patient 1 ((a), (b)) with immunotherapy responsive voltage-gated potassium channel antibody and antithyroperoxidase antibody-associated subacute encephalitis illustrates increased signal in the bilateral medial temporal lobes on T2 fluid attenuated inversion recovery (T2 FLAIR) sequences ((a) initial image). Follow up image after 8 months (b) was unchanged. Brain MRI of case 2 illustrates increased signal in the bilateral medial temporal lobes on T2 FLAIR ((c) initial image) and after 13 months (d) shows its resolution; T1 with contrast sequence ((e) initial image) shows bilateral temporal atrophy and after 13 months (f) showing persistent bilateral frontotemporal atrophy.
CRM2010-837371.001.jpg
PMC2843900_02_CRM2010-837371.001.jpg
fig1
MRI of the brain showed mild hyperintensity in bilateral hippocampal areas on T2 flair sequences and significant atrophy in the frontotemporal lesion (Figure 1). Repeat MRI, 13 months after the initial MRI, showed persistent atrophy in frontotemporal region but resolution of the hyperintense lesions in the bilateral hippocampal areas (Figure 1).
PMC2843900_02
MRI findings in two cases of immunotherapy responsive autoimmune subacute encephalitis. Brain MRI of Patient 1 ((a), (b)) with immunotherapy responsive voltage-gated potassium channel antibody and antithyroperoxidase antibody-associated subacute encephalitis illustrates increased signal in the bilateral medial temporal lobes on T2 fluid attenuated inversion recovery (T2 FLAIR) sequences ((a) initial image). Follow up image after 8 months (b) was unchanged. Brain MRI of case 2 illustrates increased signal in the bilateral medial temporal lobes on T2 FLAIR ((c) initial image) and after 13 months (d) shows its resolution; T1 with contrast sequence ((e) initial image) shows bilateral temporal atrophy and after 13 months (f) showing persistent bilateral frontotemporal atrophy.
CRM2010-837371.001.jpg
PMC2843900_02_CRM2010-837371.001.jpg
fig1
MRI of the brain showed mild hyperintensity in bilateral hippocampal areas on T2 flair sequences and significant atrophy in the frontotemporal lesion (Figure 1). Repeat MRI, 13 months after the initial MRI, showed persistent atrophy in frontotemporal region but resolution of the hyperintense lesions in the bilateral hippocampal areas (Figure 1).