PMC7345608_01
Thyroid nodule FNAB, Diff-Quick stain with marked cellularity of atypical spindle cells, dyscohesive, and in tissue aggregates with some binucleated cells.
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The Diff-Quick stain showed marked cellularity of atypical spindle cells, dyscohesive, and in tissue aggregates with some binucleated cells (Figure 1).
Postsurgical histology hematoxylin-eosin staining showed a spindle cell tumor with frequent mitotic figures.
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After total thyroidectomy was performed, hematoxylin-eosin staining showed a spindle cell tumor with frequent mitotic figures (Figure 2).
Immunohistochemical stains for (a) cytokeratin AE1/AE3 and (b) thyroglobulin showing entrapped thyroid follicles within fascicles of spindle tumor cells positive for (c) smooth muscle actin (SMA) and (d) desmin.
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The tumor cells stained positive for smooth muscle actin (SMA) and desmin (Figure 3) and negative for cytokeratin and thyroglobulin.