PMC8463200_01
Heart rate throughout hospitalization for each patient. Every discrete heart rate datapoint as recorded in the electronic medical record throughout each patient's hospital stay, with patients' data shown adjacent to one another using a uniform y-axis, but individually labeled x-axes. The proportion of recorded values found to be bradycardic is noted at the bottom of each patient's dataset. HR: heart rate; %: percentage; x-axis: duration of hospitalization (continuous measure of time, no discrete intervals used); y-axis: heart rate in beats per minute.
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fig1
He experienced persistent bradycardia for five days, starting on day six of his hospitalization (Figures 1, 2). She developed bradycardia on hospital day four, which resolved on day 9 (Figures 1 and 2). On hospital day three, she developed eight days of persistent bradycardia (Figures 1 and 2). She started experiencing persistent bradycardia lasting eight days on hospital day four (Figures 1 and 2). On hospital day three, he developed persistent bradycardia lasting five days (Figures 1 and 2).
Average heart rate throughout hospitalization juxtaposed with remdesivir administration. Each patient's average daily heart rate in beats per minute is juxtaposed in this figure with documented hospital days of remdesivir administration. Every patient received five consecutive doses of remdesivir, starting on the first full day of hospitalization unless otherwise noted in the case descriptions. The second documented day of hospitalization was the first full day of hospitalization for patients who were admitted in the afternoon or evening of the day prior. The first day and last days of administration as follows in a "first day/last day" format: patient (1) 5/9, patient (2) 2/6, patient (3) 2/6, patient (4) 2/6, patient (5) 4/8, patient (6) 1/5. The threshold for bradycardia is noted, and the third day after the last dose of Remdesivir is noted. Recovery from bradycardia was expected at this point should remdesivir be causative.
CRIC2021-9986955.002.jpg
PMC8463200_01_CRIC2021-9986955.002.jpg
fig2
He experienced persistent bradycardia for five days, starting on day six of his hospitalization (Figures 1, 2). She developed bradycardia on hospital day four, which resolved on day 9 (Figures 1 and 2). On hospital day three, she developed eight days of persistent bradycardia (Figures 1 and 2). She started experiencing persistent bradycardia lasting eight days on hospital day four (Figures 1 and 2). On hospital day three, he developed persistent bradycardia lasting five days (Figures 1 and 2).