PMC3806704_01
Multiple patchy lesions on an axial FLAIR image located in the subcortical white matter affecting also the internal capsule on the left side.
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F1
MRI of the brain showed widespread white-matter lesions in both hemispheres, more extensively on the left side involving the frontal, parietal and occipital lobes (fig. 1).
a Routine HE-saffron section with enlarged abnormal oligodendroglial cell nuclei (arrow) and gliosis (arrowheads indicate gemistocytic astrocytes). x40. b Massive gliosis with gemistocytic astrocytes, some with irregular nuclei. x40.
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PMC3806704_01_crn-0005-0149-g02.jpg
F2
The microscopic examination revealed areas with demyelination, a variable number of macrophages, enlarged purple-stained oligodendroglial nuclei and massive gliosis with gemistocytic astrocytes, some with bizarre nuclei (fig. 2).