PMC6769215_01
Skin lesions in trunk and hands.. The patient presented multiple non-homogeneous, hypochromic, well-defined macules associated with post-inflammatory hypopigmentation in the skin of the upper back (panel A). In the interdigital region of both hands, the patient presented white-yellowish, confluent, smooth-surface papules with irregular borders. Similar lesions were found in the dorsum of the hand (panel B).
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There was generalized mucocutaneous jaundice with multiple zones of post-inflammatory hypopigmentation (Figures 1 to 3) and yellowish, well-defined papules in the perioral area (Figure 2) and interdigital folds (Figure 1).
Lesions in the skin of the face.. The patient presented multiple yellowish papules with smooth, shiny surface and regular, well-defined borders in the perioral region (panel A) and chin (panel B).
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There was generalized mucocutaneous jaundice with multiple zones of post-inflammatory hypopigmentation (Figures 1 to 3) and yellowish, well-defined papules in the perioral area (Figure 2) and interdigital folds (Figure 1).
Lesions in the skin of the limbs.. The patient presented multiple non-homogeneous, hypochromic macules with associated mild excoriations in the legs and knees (panel A) and the forearm (panel B).
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There was generalized mucocutaneous jaundice with multiple zones of post-inflammatory hypopigmentation (Figures 1 to 3) and yellowish, well-defined papules in the perioral area (Figure 2) and interdigital folds (Figure 1).
Lesions in the skin of the hands, after 4 months of treatment: (a) Dorsum of the hands. (b) Palms of the hands.. There was a noticeable reduction in the number and severity of papules and in the associated hypopigmentation.
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Over the first few weeks of management, the patient exhibited progressive improvement of pruritus, jaundice, and skin lesions (Figure 4), in addition to a decline in plasma markers of cholestasis (Table 1).
Results from non-denaturing lipoprotein gel electrophoresis in 5% agarose.. We ran in parallel and under the same conditions, plasma from the patient and from 3 healthy controls.
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Bands from controls exhibited a typical migration pattern with beta migration for LDL and alpha migration for HDL, whereas the patient's sample showed essentially a pattern of zero to gamma mobility, consistent with the presence of LpX (Figure 5).