PMC10467227_01
Widespread pink-to-erythematous papules, vesicles, and bullae with a few scattered pustules over the trunk.
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A 53-year-old female with a history of Darier's disease diagnosed at the age of 47 years presented with a sudden onset of widespread pruritic vesicles and papules over her extremities and back (Figures 1 and 2).
Close-up of vesicles and crusted papules on the back.
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A 53-year-old female with a history of Darier's disease diagnosed at the age of 47 years presented with a sudden onset of widespread pruritic vesicles and papules over her extremities and back (Figures 1 and 2).
(a) Low-power histologic image depicting prominent suprabasilar and intraepidermal vesicle with lymphocytic infiltrate acantholysis and dyskeratosis. Magnification 10x (b) High-power histologic image depicting suprabasilar and intraepidermal vesicle with dense dermal lympho-eosinophilic infiltrate. Magnification 40x.
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A skin biopsy of an intact vesicle was performed showing prominent lymphocytic infiltrate with acantholysis and dyskeratosis, and in the area of the vesicle formation, there was a suprabasilar split with scattered eosinophils and occasional dyskeratotic cells (Figure 3).