PMC6370615_01
EEG demonstrations before quinidine therapy. (A) Interictal EEG before quinidine therapy showed a large number of 3-5 Hz slow waves with middle and high amplitude in the anterior region in background. (B) Multiple-spike-and-slow-waves of 0.5-1 Hz were observed during the sleep period. (C) Slow spike-and-slow-waves of 1.5-2.5 Hz were observed when the patient was awake. (D) Ictal EEG of the tonic seizure showed short-term fast rhythms burst of 16-20 Hz.
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F1
Slow spike-and-slow-waves of 1.5 to 2.5 Hz were observed during awake time (Figure 1).
The changes of the seizure frequency and epileptiform discharges along with the changes of quinidine dosages. (A) The patient was given quinidine at a starting dosage of 5 mg/kg/day. The dose slowly increased and maintained at 13.75 mg/kg/day. As the dosage of quinidine increased, the frequency of tonic seizures (the main type of seizures in the patient) gradually reduced from 16 times per month to 4 times per month. (B) The epileptiform discharge of EEG was 1,323 times per 24 h before taking the quinidine. The epileptiform discharge was 512 times per 24 h in the 3rd month, 652 times per 24 h in the 6th month, 598 times per 24 h in the 9th month. With the increase of dosages, the epileptiform discharge showed a significant reduction.
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F2
The frequency of tonic seizures subsided by 75% (Figure 2A), whereas the frequency of the other types of seizures was not reduced significantly. The epileptiform discharges decreased by 54.80% (Figure 2B).