PMC8055361_01
(A) Preoperative facial and chest signs of Case 1 and Case 3. (B) Hand deformity of Case 1, Case 2, Case 3. Upper: the father; below: the sister; left: the brother. (C) Facial characteristics of Case 1, Case 2 (postoperative) and Case 3.
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The shape of the head was normal, the orbital distance was significantly widened, the nose presented with saddle malformation, and the ears were protruding (Figure 1A and C). The aperture of the thorax was malformed, greater pectoral muscles were hypertrophic, and bilateral nipple areolas were absent (Figure 1A). The fingers of both hands were short, the distal phalanx of the little fingers presented with slight flexion and deformity, and the hands were webbed (Figure 1B).
Preoperative and postoperative chest signs of Case 1. (A) Preoperative chest signs of Case 1 (the lower left is artificial skin injury, not nipple). (B) Sign of axillary hair absence in Case 1. (C) Chest sign of Case 1 one year after nipple reconstruction and embroidery.
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A follow-up was conducted three years after the operations (Figure 2C).
PMC8055361_02
(A) Preoperative facial and chest signs of Case 1 and Case 3. (B) Hand deformity of Case 1, Case 2, Case 3. Upper: the father; below: the sister; left: the brother. (C) Facial characteristics of Case 1, Case 2 (postoperative) and Case 3.
CCID-14-377-g0001.jpg
PMC8055361_03_CCID-14-377-g0001.jpg
f0001
The shape of the head was normal, the orbital distance was significantly widened, the nose presented with saddle malformation, and the ears were protruding (Figure 1A and C). The aperture of the thorax was malformed, greater pectoral muscles were hypertrophic, and bilateral nipple areolas were absent (Figure 1A). The fingers of both hands were short, the distal phalanx of the little fingers presented with slight flexion and deformity, and the hands were webbed (Figure 1B).
Preoperative and postoperative facial and chest signs of Case 2. (A) Preoperative facial and chest signs of Case 2. (B) Chest sign one year after breast reconstruction. (C) Facial signs one month after eye and nose plastic surgery. (D) Chest sign one year after breast reconstruction.
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After ten months, she underwent nipple reconstruction and auricular cartilage, silica gel prosthesis rhinoplasty, and epicanthus correction (Figure 3C). During follow-ups, the shapes of her breasts and areolas were good (Figure 3D).
PMC8055361_03
(A) Preoperative facial and chest signs of Case 1 and Case 3. (B) Hand deformity of Case 1, Case 2, Case 3. Upper: the father; below: the sister; left: the brother. (C) Facial characteristics of Case 1, Case 2 (postoperative) and Case 3.
CCID-14-377-g0001.jpg
PMC8055361_03_CCID-14-377-g0001.jpg
f0001
The shape of the head was normal, the orbital distance was significantly widened, the nose presented with saddle malformation, and the ears were protruding (Figure 1A and C). The aperture of the thorax was malformed, greater pectoral muscles were hypertrophic, and bilateral nipple areolas were absent (Figure 1A). The fingers of both hands were short, the distal phalanx of the little fingers presented with slight flexion and deformity, and the hands were webbed (Figure 1B).
Preoperative and postoperative chest signs of Case 1. (A) Preoperative chest signs of Case 1 (the lower left is artificial skin injury, not nipple). (B) Sign of axillary hair absence in Case 1. (C) Chest sign of Case 1 one year after nipple reconstruction and embroidery.
CCID-14-377-g0002.jpg
PMC8055361_03_CCID-14-377-g0002.jpg
f0002
A follow-up was conducted three years after the operations (Figure 2C).
Preoperative and postoperative facial and chest signs of Case 2. (A) Preoperative facial and chest signs of Case 2. (B) Chest sign one year after breast reconstruction. (C) Facial signs one month after eye and nose plastic surgery. (D) Chest sign one year after breast reconstruction.
CCID-14-377-g0003.jpg
PMC8055361_03_CCID-14-377-g0003.jpg
f0003
After ten months, she underwent nipple reconstruction and auricular cartilage, silica gel prosthesis rhinoplasty, and epicanthus correction (Figure 3C). During follow-ups, the shapes of her breasts and areolas were good (Figure 3D).