PMC7445501_01
Photograph of the lesion on the left nipple. Erosion and crust on the left nipple.
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The surface of the lesion was rough and thickened with clear border, the texture was firm without tenderness (Figure 1).
(A and B) Histopathology reveals ductal differentiation. (Hematoxylin-eosin stain, Original magnificationx40 (A); Original magnificationx200 (B)). The luminal epithelial cells were positive for (C) CK5/6 stain. (Immunohistochemistry, original magnificationx100). The out-layer myoepithelial cells were positive for (D) SMA and (E) p63 stains. (Immunohistochemistry, original magnificationx100).
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The glands were composed of monolayer columnar epithelial cells with papillomatous hyperplasia in the lumina (Figure 2A and B). The luminal epithelia of the glands were positive for epithelial membrane antigen and cytokeratin five-sixths staining (Figure 2C), which confirmed the proliferation of usual ductal epithelium cells. Smooth muscle actin (Figure 2D) and p63 demonstrated that there were myoepithelial cells surrounding the luminal epithelial cells (Figure 2E).