PMC3364039_01
Liver biopsy revealing the presence of a non-caseating granuloma (arrow) with epitheloid cells.
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F1
Histopathologic evaluation of the biopsy specimen revealed non-caseating granulomatous inflammation with moderate periportal fibrosis, consistent with hepatic sarcoidosis (fig. 1).
a Enlarged spleen with multiple nodular pattern typical of sarcoidosis. b Microscopic specimen of the spleen revealing multiple non-caseating granulomas (arrows) composed of epitheloid cells and multi-nuclear giant cells.
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F2
Gross examination of the spleen revealed it to be markedly enlarged, weighing approximately 990 g (fig. 2a). Histopathologic examination of the splenic tissue showed diffuse confluent non-caseating granulomas and foreign body giant cells containing polarized foreign bodies with some patchy areas of calcification, highly consistent with sarcoidosis (fig. 2b).
CT scan of the abdomen. Note the diffuse heterogeneity of the liver parenchyma with diffuse nodularity of the liver contour (arrows), highly suggestive of liver cirrhosis. Mild ascites was also noted (arrowhead).
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F3
A repeat CT scan of the abdomen 6 months later revealed mild diffuse heterogeneity of the liver parenchyma with diffuse nodularity of the liver contour, highly suggestive of cirrhosis (fig. 3).