PMC6333076_01
Histopathological features of renal sarcoma demonstrate hypercellular fascicles of spindle cells with elongated, hyperchromatic nuclei, and eosinophilic cytoplasm. Thin, pink, and wavy fibers between the tumor cells are indicative of a sarcoma with fibroblastic differentiation
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Thin, pink, wavy fibers between the tumor cells were characteristic of collagen and were indicative of a sarcoma with fibroblastic differentiation (Figure 1).
Showing the degree of invasion of the recurring tumor into the colon. The colon was divided at the level of the splenic flexure proximally and at the upper sigmoid distally with primary colo-colic anastomosis
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A week after, the patient underwent en bloc excision of the retroperitoneal mass with a segment of the left diaphragm, left psoas muscle, and the descending colon (Figure 2) along with an extensive lymph node dissection and colo-colic anastomosis.
Histopathological characteristics of the recurring tumor depict features of malignant sarcoma with areas of myxoid stroma that contain elongated, thin-walled blood vessels, resembling the morphology of myxofibrosarcoma
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There were areas with more myxoid stroma that contained elongated, thin-walled blood vessels, resembling the morphology of myxofibrosarcoma (Figure 3).
Fluorescent in situ hybridization (FISH) shows amplification of MDM2 gene on the short arm of chromosome 12 (12q15) which strongly supports the diagnosis of dedifferentiated liposarcoma
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Fluorescent in situ hybridization (FISH) for MDM2 showed amplification (Figure 4), which strongly supported the diagnosis of dedifferentiated liposarcoma.