PMC9938344_01
Peripheral blood smear showing characteristic hairy cell along with marked thrombocytopenia and hypochromic anemia with nucleated RBCs and anisocytosis. RBCs: Red blood cells.
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FIG1
The peripheral blood smear showed marked thrombocytopenia without aggregation and hypochromic anemia with the presence of nucleated red blood cells and anisocytosis (Figure 1).
A hypercellular bone marrow packed with small leukemic cells having moderate light basophilic cytoplasms and circumferential hairy projections. This image was originally published in the American Society of Hematology (ASH) Image Bank.
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FIG2
The reticulin stain demonstrated no significant increase in reticulin fibers (Figure 2).
Flow cytometry showing clonal CD19 and CD20-positive B-cell population with kappa restriction and CD11c, CD25 and CD103. This image was originally published in the American Society of Hematology (ASH) Image Bank.. CD: Cluster of differentiation.
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FIG3
The patient's flow cytometry analysis revealed clonal cluster of differentiation 20 (CD20)-positive B cells with CD11c, CD25, CD103, CD10, and kappa (kappa) light chain restrictions, which are highly suggestive of HCL (Figure 3).
Bone marrow showing CD20-positive leukemic cells. CD: Cluster of differentiation.
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FIG4
The leukemic cells were positive for CD20, CD25, CD10, Annexin A1, and tartrate-resistant acid phosphatase (TRAP) stain and negative for CD123 (Figures 4-7).
Bone marrow showing CD25-positive leukemic cells. CD: Cluster of differentiation.
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FIG5
The leukemic cells were positive for CD20, CD25, CD10, Annexin A1, and tartrate-resistant acid phosphatase (TRAP) stain and negative for CD123 (Figures 4-7).
Bone marrow showing leukemic cells positively staining with Annexin A1
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FIG6
The leukemic cells were positive for CD20, CD25, CD10, Annexin A1, and tartrate-resistant acid phosphatase (TRAP) stain and negative for CD123 (Figures 4-7).
Bone marrow showing leukemic cells positively staining with TRAP stain. TRAP: Tartrate-resistant acid phosphatase.
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FIG7
The leukemic cells were positive for CD20, CD25, CD10, Annexin A1, and tartrate-resistant acid phosphatase (TRAP) stain and negative for CD123 (Figures 4-7).