PMC5506080_01
Gross Pathology images of two separate ART16/ART16 pigs (BMT1, BMT2) diagnosed with T cell lymphoma. (A) Multiple smooth tan nodules 1-6 cm in diameter in the lung from BMT1 and similar (B) tan cranial mediastinal mass of thymic origin from BMT2.
fimmu-08-00813-g002.jpg
PMC5506080_02_fimmu-08-00813-g002.jpg
F2
Pig 2 (BMT2), an 11-month-old ART16/ART16 female had a 5-cm tan cranial mediastinal mass (Figure 2B).
Histologic staining documenting characteristic T cell lymphoma. (A) An example of the neoplastic sheets collected from thoracic tumor. (B) Stained tumor mass showing CD3+ T cell positive phenotype. (C) Stained tumor mass showing CD79- B cell negative tissue staining.
fimmu-08-00813-g003.jpg
PMC5506080_02_fimmu-08-00813-g003.jpg
F3
Microscopically the mass was composed of densely packed uniform sheets of small to medium sized neoplastic lymphocytes similar to those seen in Figure 3A for BMT1. Neoplastic lymphocytes were diffusely positive for CD3 and negative for CD79 as seen in Figures 3B,C.
PMC5506080_02
Engraftment parameters of Severe Combined Immunodeficiency (SCID) pigs after opposite sex, 100% MHC matched donor bone marrow transplantation. (A) Recovery of lymphocyte numbers to within a normal range of BMT SCID pigs (dashed line) compared to non-SCID littermates (solid line) monitored by complete blood counts ever 2 weeks after transplant. (B) Antibody response to vaccination for Circumvent (against circovirus) for both ART16/ART16 pigs (BMT1, BMT2) for total immunoglobulin (Ig)G and (C) IgM. Only applicable to female recipients of male donor cells, pig SRY gene expression (detection of Y Chromosome) was determined as a percentage of sample from (D) isolated PBMCs and (E) whole blood from BMT2, BMT4. Figure created with ggplot2.
fimmu-08-00813-g001.jpg
PMC5506080_02_fimmu-08-00813-g001.jpg
F1
Microscopically the mass was composed of densely packed uniform sheets of small to medium sized neoplastic lymphocytes similar to those seen in Figure 3A for BMT1.
Gross Pathology images of two separate ART16/ART16 pigs (BMT1, BMT2) diagnosed with T cell lymphoma. (A) Multiple smooth tan nodules 1-6 cm in diameter in the lung from BMT1 and similar (B) tan cranial mediastinal mass of thymic origin from BMT2.
fimmu-08-00813-g002.jpg
PMC5506080_02_fimmu-08-00813-g002.jpg
F2
Pig 2 (BMT2), an 11-month-old ART16/ART16 female had a 5-cm tan cranial mediastinal mass (Figure 2B).
Histologic staining documenting characteristic T cell lymphoma. (A) An example of the neoplastic sheets collected from thoracic tumor. (B) Stained tumor mass showing CD3+ T cell positive phenotype. (C) Stained tumor mass showing CD79- B cell negative tissue staining.
fimmu-08-00813-g003.jpg
PMC5506080_02_fimmu-08-00813-g003.jpg
F3
Microscopically the mass was composed of densely packed uniform sheets of small to medium sized neoplastic lymphocytes similar to those seen in Figure 3A for BMT1. Neoplastic lymphocytes were diffusely positive for CD3 and negative for CD79 as seen in Figures 3B,C.