PMC7874168_01
Family pedigree.
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F1
Moreover, proband's only 8-year-old male child is affected by a classical FMF phenotype with recurrent serositis and self-limiting fever attacks (Figure 1).
Brain and spinal cord MRI. Brain MRI images (Fluid Attenutated Inversion Recovery coronal and axial projections, Double Inversion Recovery sagittal projection) showing typical MS lesions involving bi-hemispheric white matter (A). Cervical MRI image (Short Time Inversion Inversion Recovery and T1-gd+ sagittal projection) at diagnosis (B) showing a C2-C3 level lesion with gd-enhancement (arrow), resolution after steroid treatment (C) and stability at 4-month follow-up after two cycles of Rituximab (D).
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F2
He performed a brain and spinal cord MRI, which showed multiple supra- and infratentorial lesions (Figure 2A) and a gadolinium-enhancing lesion in the cervical spinal cord at right lateral C2-C3 level responsible for symptoms (Figure 2B). One month-follow up MRI was stable in terms of lesion burden, and the cervical lesion no longer showed gd-enhancement (Figure 2C). No additional lesions were detected at last brain and cervical spinal cord MRI performed in 6/2020 (Figure 2D).