PMC10345201_01
The neoplastic cells demonstrated marked pleomorphism, with increased nucleo-cytoplasmic ratio and irregular nucleus shape ((A), HE staining, 200X). The IHC staining revealed positive expression of P40 ((B), 200X) and P63 ((C), 200X). The Ki-67 proliferative index was approximately 70% ((D), 200X).
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PMC10345201_01_pore-29-1611259-g001.jpg
F1
The IHC staining showed positive expression of CD15, CD10, P40, and P63, the Ki-67 proliferative index was 70% (Figure 1).
Pathology of the second patient revealed classic morphology of sebaceous carcinoma (HE staining, 100X).
pore-29-1611259-g002.jpg
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F2
An excisional biopsy confirmed the diagnosis of moderately differentiated vulval SC (Figure 2).
PMC10345201_02
Pathology of the second patient revealed classic morphology of sebaceous carcinoma (HE staining, 100X).
pore-29-1611259-g002.jpg
PMC10345201_02_pore-29-1611259-g002.jpg
F2
An excisional biopsy confirmed the diagnosis of moderately differentiated vulval SC (Figure 2).