PMC3899932_01
Case 1. Magnetic resonance imaging (MRI) and macroscopy. (A-B) T2-weighted MRI showing hyperintense, multinodular solid lesions in the subcortical white matter of the medial part of the left superior frontal gyrus without tissue expansion or mass effect (white arrow). (C) Coronally sectioned surgically removed material reveals coalescing grey nodules (black arrow) (bar = 5 mm). (D) Low power microscopy demonstrates hypomyelinated plaque-like nodules extending into the deep cortex (Luxol fast blue - Nissl) (bar = 1 mm).
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T2-weighted hyperintense lesions within the subcortical white matter of the antero-medial aspect of the left superior frontal gyrus (Figure 1), suggestive of DNT.
PMC3899932_02
Case 2. MRI and macroscopy. (A-B) MRI showing extensive, T2-weighted hyperintense, nodular lesions in the white matter of the left posterior temporal lobe (between white arrows). No change was noted on follow up MRI in 15 months. (C) Coronally sectioned temporal lobe block from autopsy reveals numerous coalescing grey nodules along the junction of cortex and grey matter and in the subjacent white matter, which appear as hypomyelinated nodules by Luxol fast blue - Nissl (bar = 1 cm).
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