PMC3133001_01
Fundus photograph (A), fluorescein angiography (B), slit-lamp biomicroscopy (C), and gadolinium-enhanced T1-weighted MRI of the right eye (D). A) The fundus was blurred due to the dense vitreous opacity. The optic disc was swollen, and there was an elevated orange-colored subretinal lesion situated adjacent to the optic disc (arrowhead). B) Hyperfluorescence in the initial phase (arrowhead) in the orange-colored subretinal lesion and optic disc. C) Whitish dense anterior vitreous opacity. D) A markedly enhanced appearance underlying the posterior retina.
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Funduscopic examination showed optic disc swelling, dense whitish vitreous opacity, and an orange-colored subretinal elevated lesion (Figure 1A, arrowhead) adjacent to the optic disc. Fluorescein angiography revealed hyperfluorescence in the peripapillary region at an early phase OD (Figure 1B). Slit-lamp biomicroscopy showed a dense anterior vitreous opacity (Figure 1C). Gadolinium-enhanced magnetic resonance imaging showed a markedly enhanced appearance of the underlying posterior retina (Figure 1D).
Histopathology of the enucleated eye. Hematoxylin and eosin staining. A) Retinal detachment with a huge choroidal mass invading the optic nerve head. Bar indicates 3 mm. B) Tumor cells invaded the ganglion cell layer without forming masses. Bar indicates 50 um. C) Tumor cells were tightly packed, and contained large hyperchromatic nuclei and scant cytoplasm. Rosette formation was observed in the choroidal mass. Bar indicates 50 um. D) Tumor cells infiltrated the parenchyma of the optic nerve and subarachnoid space (arrow). Bar indicates 50 um.
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Histopathology demonstrated retinal detachment and a huge choroidal mass invading the optic nerve head (Figure 2A). In the retina, tumor cells invaded the ganglion cell layer without forming masses (Figure 2B). Rosette formation was frequently observed (Figure 2C), but neither a necrotic area nor calcified lesion was found. There were infiltrating tumor cells in the parenchyma of the optic nerve and subarachnoid space (Figure 2D, arrow).