PMC10062080_01
(a) Gross enface view of posterior surface of cornea showing extensive pigmentation of the endothelial surface. (b) Gross photograph of retinal pigment epithelium degeneration
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F1
Posterior surface of the cornea showed pigment depositions around the empty looking endothelial cells [Figure 1a]. Retinal pigment epithelium (RPE) showed hypertrophic and atrophic areas stained under fluorescein dye in raw tissue [Figure 1b].
(a) Pigment depositions being noted on the endothelial side of the cornea and some of the pigments being in spindle-shaped pattern like Krukenberg's spindles (H and E, x40). (b) Homogeneous pigmentation of the trabecular mesh-work. Pigmentation extended to posterior trabeculum with pigmented granules seen in intratrabecular space (H and E, x10)
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F2
Pigment depositions were noted on the endothelial side of the cornea, and some of the pigments were in spindle-shaped pattern such as Krukenberg's spindles [Figure 2a]. Trabecular meshwork showed hyperpigmentation which was homogenous in nature [Figure 2b].
(a) Pigmented cell seen outside the sclera (marked with an arrow, H and E, x40). (b) Pigmented cells (marked with arrows) in the anterior vitreous cavity (H and E, x20)
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F3
Pigment cells were seen outside the sclera and in vitreous cavity [Figure 3].