PMC4147195_01
PAS stained renal biopsy of our patient showing the characteristic histologic features of a MPGN type 1 (thickening of the basement membrane, diffuse mesangial expansion, and proliferation). Furthermore, a discrete extracapillary proliferative component and a diffuse tubulointerstitial damage were present.
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Histological workup showed a severe diffuse membranoproliferative glomerulonephritis (MPGN) type 1 with a discrete extracapillary proliferative component and a diffuse tubulointerstitial damage (Figure 1).
Trend of crucial laboratory parameters. (a) HCV-RNA blood levels in IU/mL. After initiation of triple therapy, the levels fell continuously and were negative for the first time after 10 weeks of therapy. (b) Serum creatinine blood levels in mg/dL. At admission, the creatinine was considerably elevated and fell constantly after start of therapy. (c) Proteinuria in g protein/g creatinine. Quickly after initiation of antiviral therapy, proteinuria decreased dramatically and remained low over the whole time of surveillance.
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The creatinine level dropped within the normal range and the proteinuria declined from initially 12.5 g protein/g creatinine to 0.4 g protein/g creatinine (Figure 2).