PMC6014238_01
(A) Endometrial mucinous carcinoma showing complex glandular structures with back-to-back arrangement [hematoxylin and eosin (H&E), 200x]; (B) endometrial mucinous carcinoma showing positive staining to periodic acid-Schiff before and after digestion (periodic acid-Schiff-diastase, 200x); (C) appendicular tumor composed of confluent papillary structures displaying a circumferential growth pattern all over the appendiceal lining mucosa (H&E, 100x); (D) appendicular tumor, high-power view showing bland-looking tumor cells (H&E, 200x); (E) small benign-looking mucin-filled cyst within the ovarian stroma (H&E, 200x); and (F) omentum revealed noninvasive acellular mucin pools bisecting fat lobules (H&E, 200x).
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F1
The glandular lumina are loaded with mucin and heavy neutrophilic infiltrate (Fig. 1A). The intracytoplasmic and intraluminal secretions were proved by periodic acid-Schiff and periodic acid-Schiff-diastase stains (Fig. 1B). Chronic inflammatory cells are seen (Fig. 1C and D). Both ovaries and tubes were unremarkable, except for a mucous cyst 1 cm in diameter lined by flattened epithelium and is full of mucin in the left one (Fig. 1E). An examination of the omentum revealed noninvasive a cellular mucin pools bisecting fat lobules (Fig. 1F).
Immunohistochemical study of endometrial carcinoma showing: (A) strong positive immunostaining to cancer antigen 125 [immunohistochemistry (IHC), 100x], (B) strong nucleocytoplasmic staining to Wilms tumor-1 (IHC, 100x), (C) negative immunoreactivity of tumor cells to cytokeratin 7 in contrast to positive normal glands (IHC, 100x), and (D) strong nuclear staining of tumor cells as well as stromal cells to antibody to estrogen receptor (IHC, 100x).
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F2
Immunohistochemical study of appendiceal mucinous tumor showed (A) strong positive cytoplasmic immunoreactivity to cytokeratin 20 (immunohistochemistry, 200x), and (B) strong positive immunoreactivity to caudal-type homeobox 2 in cytoplasm and luminal border (immunohistochemistry, 200 x).
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F3