PMC10450960_01
(A) Hematoxylin and eosin stain (200x): the tumor shows endocervical adenocarcinoma (common type); (B-D) immunohistochemical stains (200x) are positive for P16 (B), P53 wild type (C), and negative for WT-1 (C).
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PMC10450960_01_fonc-13-1244202-g001.jpg
f1
The immunohistochemistry staining results of both the cervical and right ovarian metastatic cancers were P16(+++), P53 wild type (+), Muc-5(+++), CK7(+++), ER(-), PR(-), Muc-2(-),WT-1(-), and CK20(-), and the Ki67 proliferative index was 90% ( Figure 1 ).
PMC10450960_02
(A) Hematoxylin and eosin stain (200x): the tumor shows G-EAC; (B-D) immunohistochemical stains (200x) are focally positive for P53 muted type (B), Muc-6 (C), and CK7 (D).
fonc-13-1244202-g002.jpg
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f2
The immunohistochemistry (IHC) staining results of the cervix were CK7(+), P53 muted type(+), Villin(+), Muc-6(+), P16(+, focally), Pax-8(+, focally), Muc-5(+), ER(-), PR(-), CK20(-), and CDX-2, and the Ki67 proliferative index was 10% ( Figure 2 ).