PMC5618755_01
Coronal (a) and transverse (b) views of abdominal computed tomography demonstrate 7.27 x 6.00 x 5.50 cm heterogeneous mass in the left native kidney. Both kidneys show signs of atrophy.
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fig1
A suspicious heterogeneous mass was noted within the left native kidney that measured 6.0 x 5.5 x 7.3 cm in anteroposterior, transverse, and craniocaudal dimensions (Figure 1).
Histologic and immunophenotypic features of collecting duct carcinoma. (a) Tumor cells form solid sheets (20x). (b) Linear and single cell infiltration (20x). (c) Prominent large nucleoli (40x). (d) Positive for PAX8, consistent with renal origin. (e) Negative for GATA-3, ruled out urothelial origin. (f) INI-1 retained, ruled out medullary carcinoma.
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fig2
Some areas showed solid tumor nests (Figure 2(a)), while another showed linear and single cell infiltration with prominent desmoplasia (Figure 2(b)). The tumor cells had marked nuclear pleomorphism, high nuclear : cytoplasmic (N : C) ratio, and prominent nucleoli (Figure 2(c)).