PMC5660899_01
Radiological and pathological characteristics of solid pseudopapillary neoplasm in case 1. A) CT scan demonstrating a well-delineated and heterogeneous enhancing mass of the pancreatic tail with peripheral calcifications; B) cut section of the tumour demonstrating a heterogeneous predominantly solid mass surrounded by a thick fibrous capsule with extensive necrosis; C) tumour proliferation surrounded by a thick fibrous capsule. The growth pattern is heterogeneous, with a combination of soild and pseudopapillary in various proportions (H & E, original magnification x 40); D) loosely cohesive tumour cells radiating around blood vessels reminiscent of pseudorosettes in ependymoma (H & E, original magnification x 200)
PAMJ-27-283-g001.jpg
PMC5660899_01_PAMJ-27-283-g001.jpg
f0001
Abdominal computed tomography (CT) scan showed a well-defined heterogeneous mass involving the pancreatic tail with peripheral calcifications (Figure 1a). On cut section, it showed mainly solid and partially cystic components and demonstrated focal haemorrhage and central necrosis (Figure 1b). Histologically, the tumour was circumscribed by a thick fibrous capsule (Figure 1c). The solid areas were composed of poorly cohesive monomorphic cells that were admixed with hyalinized stromal bands containing thin-walled blood vessels surrounded by loosely cohesive tumour cells radiating around blood vessels reminiscent of pseudorosettes in ependymoma (Figure 1d).
PMC5660899_02
Pathological and immunohistochemical profile of solid pseudopapillary neoplasm in case 2. A) cut section of the tumour of the head of the pancreas demonstrating a heterogeneous cystic mass surrounded by a fibrous capsule with extensive haemorrhage and necrosis; B) tumour proliferation with extensive haemorrhage and necrosis (H & E, original magnification x 40); C) tumour cells were negative for chromogranin A; D) neoplastic cells showed nuclear immunolabelling for beta-catenin (Immunohistochemistry, original magnification x 200)
PAMJ-27-283-g002.jpg
PMC5660899_02_PAMJ-27-283-g002.jpg
f0002
On cut section, it showed mainly cystic and partially solid components and demonstrated diffuse haemorrhage and necrosis (Figure 2a). The growth pattern of the tumour was heterogeneous with a combination of soild, pseudopapillary and haemorrhagic-necrotic pseudocystic structures (Figure 2b). Immunohistochemically, tumour cells showed positive immunostaining with CD56, vimentin, NSE, beta-catenin (Figure 2d), progesterone receptor. They were negative for chromogranin (Figure 2c) and synaptophysin.