PMC9561397_01
Nerve imaging and autoantibodies against NF155 and GD1b. Symmetrical bilateral enlarged cervical and lumbar plexus on MIP Thin Rage (A, B). The presence of anti-NF155 antibodies was confirmed with NF155-transfected Human Embryonic Kidney (HEK) 293 cells using a cell-based assay (CBA). Reactivity was analyzed by immunofluorescence. Serum (C) and CSF (D) anti-NF155 antibodies were positive (x400), while negative in the control group of serum (F) and CSF (G). Scale bar = 100 mum. The presence of anti-GD1b antibodies was confirmed by dot immunoassay. A clearly discernible color spot was shown in the GD1b antigen-coated area of the test strip (E, H).
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MRI and visual evoked potential (VEP) were normal. MRI of the cervical and lumbar plexus showed diffuse enlargement ( Figure 1 ). Tests for antibodies showed positive IgG4 anti-NF155 antibodies in both serum and CSF (titers of 1:320 and 1:32, respectively) and seropositive IgG anti-GD1b antibodies ( Figure 1 ).