PMC4496038_01
Management after conization in the 116 patients with invasive disease (ICC: invasive cervical carcinoma; EKC: conization using a traditional monopolar electrosurgical knife; ECC: endocervical curettages (ECC); TH: total hysterectomy; MRH: modified radical hysterectomy; RH: Radical hysterectomy; PLD: pelvic lymphadnectomy).
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PMC4496038_01_pone.0131790.g001.jpg
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Among the patients with micro-CAs, 10 patients with positive margins or ECCs underwent subsequent hysterectomy or secondary conization; 31 patients without margin involvement underwent hysterectomy because they did not desire to maintain their fertility or due to concurrent uterine myomas or adenomyosis; the other 31 patients were followed up closely (2 cases with margin involvement and 29 cases without margin involvement). (Fig 1) Among the CIN patients, 43 (55.1%) of the 78 patients with positive margins or ECCs underwent subsequent hysterectomy or secondary conization; whereas, 44 (4.3%) of 1035 patients without margin involvement underwent hysterectomy because they did not desire to maintain their fertility or due to uterine myomas or adenomyosis; the rest 1026 patients were followed up.