PMC10368095_01
Contrast-enhanced CT and colonoscopy images prior to the administration of chemotherapy. Multiple lesions of liver (a), cecum (b), and kidney (c) are shown. Colonoscopy showed an excavated lesion in the cecum (d).
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F1
Abdominal ultrasonography showed multiple diffuse space occupying lesions with a maximum diameter of 10.5 cm in the liver, and contrast-enhanced computed tomography (CT) also showed multiple lesions of liver, both kidneys, and cecum (Fig. 1a-c). Colonoscopy showed an excavated lesion in the cecum (Fig. 1d) and a biopsy was performed.
a Histopathological examination of the biopsy from the lesion of cecum showed atypical epithelial cells showing a solid pattern of proliferation. Immunohistochemically, tumor cells were positive for CAM5.2 (b), synaptophysin (c), and CD56 (d) and negative for chromogranin A (e) and CDX2 (f).
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F2
Immunohistochemically, tumor cells were positive for CAM5.2, synaptophysin, and CD56, and negative for chromogranin A and CDX2 (Fig. 2), and she was diagnosed with advanced NEC of colon.
The diffusion-weighted image of MRI of the head showed multiple small infarcts in the brain. Yellow allows indicate the lesions.
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F3
The diffusion-weighted image of MRI of the head showed multiple small infarcts in cerebral cortex and white matter (Fig. 3).