PMC5901473_01
Initial skeletal survey performed at 8 weeks of age demonstrates fraying of the metaphyses of the long bones including the distal tibia (a) and radius and ulna (b). Incidentally note the benign periosteal reaction of the newborn about the tibia. Posttreatment images at 8 months of age (c, d). Only slight cupping of the metaphyses of the tibia (c) and radius and ulna (d) remains.
CRIPE2018-5719761.001.jpg
PMC5901473_02_CRIPE2018-5719761.001.jpg
fig1
Repeat imaging obtained after 1 month of asfotase alfa, when the patient was 8 months old, revealed only slight cupping of the metaphyses of the tibia and radius and ulna (Figure 1).
Pretreatment AP (a) and oblique (b) views of the chest show widening and cupping of the costochondral junctions.
CRIPE2018-5719761.002.jpg
PMC5901473_01_CRIPE2018-5719761.002.jpg
fig2
The skeletal survey was interpreted as demonstrating cupping and metaphyseal irregularities in the majority of the long bones and costochondral areas, most consistent with rickets (Figures 1 and 2).
PMC5901473_02
Initial skeletal survey performed at 8 weeks of age demonstrates fraying of the metaphyses of the long bones including the distal tibia (a) and radius and ulna (b). Incidentally note the benign periosteal reaction of the newborn about the tibia. Posttreatment images at 8 months of age (c, d). Only slight cupping of the metaphyses of the tibia (c) and radius and ulna (d) remains.
CRIPE2018-5719761.001.jpg
PMC5901473_02_CRIPE2018-5719761.001.jpg
fig1
Repeat imaging obtained after 1 month of asfotase alfa, when the patient was 8 months old, revealed only slight cupping of the metaphyses of the tibia and radius and ulna (Figure 1).