PMC6925823_01
T1 sagittal image showing near complete absence of cerebellum with rudimentary anterior vermis (arrow).There is also marked hypoplasia of the pons also seen in the image (diamond).
CRIPE2019-7048537.001.jpg
PMC6925823_01_CRIPE2019-7048537.001.jpg
fig1
MRI revealed microcephaly with significant cerebellar and brainstem hypoplasia (Figure 1).
(a) Normal for gestational age cerebrum with markedly diminished cerebellar volume. (b) Marked hypoplastic cerebellum with rudimentary vermis.
CRIPE2019-7048537.002.jpg
PMC6925823_01_CRIPE2019-7048537.002.jpg
fig2
The cerebellum in total measured only 2.5 cm from side to side and 1 cm from rostral to caudal, in comparison with the cerebrum, where each hemisphere measured 8 x 6.5 x 5 cm which was adequate for the gestational age (Figure 2).
(a) Flattened linear fourth ventricle with scant, abortive foliae and no delineation of cerebellar nuclei. (b) Scant, abortive foliae with molecular, Purkinje, and granular layers.
CRIPE2019-7048537.003.jpg
PMC6925823_01_CRIPE2019-7048537.003.jpg
fig3
Sections through the cerebellum revealed a well-formed and large fourth ventricle; however the cerebellar parenchyma only had rudimentary and scanty foliae (Figure 3).
A rudimentary unilateral nucleus.
CRIPE2019-7048537.004.jpg
PMC6925823_01_CRIPE2019-7048537.004.jpg
fig4
A single unilateral rudimentary cerebellar nuclei was seen (Figure 4).