PMC3005662_01
Lower extremity oedema 4 days after the initiation of insulin therapy in Case 1
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The oedema deteriorated on the fourth day, after the initiation of regular insulin administered subcutaneously, at a dose of 1.2 units/kg/day (Figure 1).
PMC3005662_02
Lower extremity oedema 5 days after the initiation of insulin therapy in Case 2
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On the fifth day of regular insulin administration, a non-tender, pitting oedema without skin discoloration developed over the ankles (Figure 2).