PMC4700626_01
Representative images of pathologic slices from fine-needle aspiration of the occipital lymph node (original magnification, x40). a Hematoxylin and eosin (H and E) stained section shows diffused tumor cells displaying characteristics of nasopharyngeal carcinoma (NPC) cells. b Immunohistochemical analysis and in situ hybridization of the occipital lymph node shows the expression of Epstein-Barr virus-encoded RNAs (EBERs) in tumor cells
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Fig1
The pathologic report after hematoxylin and eosin (H and E) staining identified poorly differentiated carcinoma, which suggested metastasis from NPC (Fig. 1a). Immunohistochemical analysis and in situ hybridization of the occipital lymph node further confirmed the presence of EBV-encoded RNAs (EBERs), indicating EBERs expression in tumor cells (Fig. 1b).
Magnetic resonance (MR) imaging of the NPC patient before treatment. T1-weighted axial MR images a without contrast, b with contrast, and c T2-weighted axial MR image show an occipital lymph node (18 mm x 19 mm) with equal T1 signal, long or equal T2 signal, and obvious enhancement (arrows). T1-weighted sagittal MR image d without contrast and e with contrast also show an enlarged lymph node with enhancement in subcutaneous tissue of the occiput (arrows)
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Fig2
An occipital lymph node of 18 mm x 19 mm was detected by MRI (Fig. 2).
MR imaging of the NPC patient at 3 months after treatment. T1-weighted axial MR image of the nasopharynx a without contrast, b with contrast, and c T2-weighted axial MR image of the nasopharynx show edema signal of the nasopharyngeal mucosa but no mass. T1-weighted axial MR image d with contrast of previous occipital lymph node level and e T2-weighted axial MR image of previous occipital lymph node level show normal structure now. T1-weighted sagittal MR images f without contrast and g with contrast reveal no mass as well
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Fig3
At 3-month follow-up, no primary lesion or lesions in lymph nodes were detected (Fig. 3).