PMC8088491_01
Pre-operative axial (a), coronal (b), and sagittal (c) post-contrast T1-weighted MR showing a right temporo-mesial lesion with an irregular peripheral enhancement.
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F1
The patient underwent functional MR showing anterior dislocation of the inferior longitudinal fasciculus. [Figures 1 and 2] show the main neuroradiological features.
Pre-operative magnetic resonance (MR) spectroscopy (a) depicts a low N-acetylaspartate (NAA) with choline (Cho)/NAA of 1.33 compared to normal brain parenchyma, suggestive for low-grade glioma; functional MR (b) showing the anterior dislocation of the inferior longitudinal fasciculus (ILF) (red tract) and a unaffected corticospinal tracts (blue tracts).
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F2
The patient underwent functional MR showing anterior dislocation of the inferior longitudinal fasciculus. [Figures 1 and 2] show the main neuroradiological features.
The histopathological findings. (a-c) Cryptococcus embedded in an amorphous eosinophilic fibrillary background. Cryptococcus is a round budding yeast (arrows) that varies in size enveloped by a mucoid capsule (E and E x20); (d) focus on a cluster of Cryptococcus (arrows) (E and E x40).
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F3
Period Acid-Schiff and mucicarmine stain revealed purple organisms and numerous budding yeasts consistent with Cryptococcus spp. [Figures 3 and 4]. Forty-four hours post-operative MRI showed a residual capsule fragment adherent to the midbrain [Figure 3].
(a-c) Period Acid-Schiff staining the amorphous eosinophilic background and, weakly, the yeasts of Cryptococcus (arrows) (E, F x20; G x40); (d) Mucicarmine staining, patchy and weakly, in red the polysaccharide capsule of the yeasts (arrows) (x20).
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F4
Period Acid-Schiff and mucicarmine stain revealed purple organisms and numerous budding yeasts consistent with Cryptococcus spp. [Figures 3 and 4].