PMC6395187_01
Histopathologic picture of our case of acantholytic squamous cell carcinoma. Infiltrating tumor cell nests with the characteristic pseudoglandular pattern, with evidence of acantholysis is present in most of the tumor cell nests: (A) hematoxylin and eosin, 40x. A higher magnification shows pseudoglandular structure lined by dysplastic squamous cells with the acantholytic cells and keratin filled in the luminal space: (B) hematoxylin and eosin, 100x. Immunohistochemical study with CD-34 illustrates positive staining with the normal vascular structure, but not the lining of the pseudoglandular structure of the tumor cell nests, a differential diagnosis from the angiosarcoma: (C) 40x. The resected specimen revealed an ulcerative lesion 6 cm x 4 cm x 3.5 cm, which extended to the maxillary sinus and bone, the infraorbital rim, ethmoid sinus, nasal mucosa, and conchae. Unfortunately, the safe margin was close to the section surface of the tumor. (D) The submandibular gland and all of the lymph nodes were free of tumor cell invasion.
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PMC6395187_02_gr1.jpg
fig1
Intraoral ASCC should be differentiated from angiosarcoma; ASCC may be effectively distinguished from angiosarcoma by appropriate immunohistochemical studies such as CD31 and CD34, (Figure 1c), and von Willebrand factor. Therefore, postoperative concurrent chemoradiotherapy and long term follow up should be considered (Figure 1).
PMC6395187_02
Histopathologic picture of our case of acantholytic squamous cell carcinoma. Infiltrating tumor cell nests with the characteristic pseudoglandular pattern, with evidence of acantholysis is present in most of the tumor cell nests: (A) hematoxylin and eosin, 40x. A higher magnification shows pseudoglandular structure lined by dysplastic squamous cells with the acantholytic cells and keratin filled in the luminal space: (B) hematoxylin and eosin, 100x. Immunohistochemical study with CD-34 illustrates positive staining with the normal vascular structure, but not the lining of the pseudoglandular structure of the tumor cell nests, a differential diagnosis from the angiosarcoma: (C) 40x. The resected specimen revealed an ulcerative lesion 6 cm x 4 cm x 3.5 cm, which extended to the maxillary sinus and bone, the infraorbital rim, ethmoid sinus, nasal mucosa, and conchae. Unfortunately, the safe margin was close to the section surface of the tumor. (D) The submandibular gland and all of the lymph nodes were free of tumor cell invasion.
gr1.jpg
PMC6395187_02_gr1.jpg
fig1
Intraoral ASCC should be differentiated from angiosarcoma; ASCC may be effectively distinguished from angiosarcoma by appropriate immunohistochemical studies such as CD31 and CD34, (Figure 1c), and von Willebrand factor. Therefore, postoperative concurrent chemoradiotherapy and long term follow up should be considered (Figure 1).