PMC6711359_01
The ecthyma gangrenosum with poor peripheral perfusion over the patient's bilateral legs.
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PMC6711359_01_fimmu-10-01953-g0001.jpg
F1
The skin rash in his lower legs progressed, and some lesions became necrosis (Figure 1).
The genetic analysis of BTK gene indicated that the hemizygous c.1632-1G>A mutation of BTK gene in the patient and the heterozygous c.1632-1G>A mutation of BTK gene in his mother.
fimmu-10-01953-g0002.jpg
PMC6711359_01_fimmu-10-01953-g0002.jpg
F2
Genetic analysis revealed a novel hemizygous c.1632-1G>A mutation in the BTK gene of the patient (Figure 2).