PMC6754894_01
Invasive ductal carcinoma (H&E).
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The histopathology exam showed proliferation of epithelial cells of the mammary canals infiltrating to the space between the canals (Figure 1) and in addition to simultaneous ductal carcinoma in situ (Figure 2).
Magnified image showing ductal carcinoma in situ.
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The histopathology exam showed proliferation of epithelial cells of the mammary canals infiltrating to the space between the canals (Figure 1) and in addition to simultaneous ductal carcinoma in situ (Figure 2).
CK7 staining with positive results indicating carcinoma.
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CK7 staining proved carcinoma origin (Figure 3).
H&E microscopic image of the left mass showing spindle-shaped cells.
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Surprisingly, histopathology of excisional biopsy performed to the left breast mass showed high cellularity of spindle-shaped cells; the mass contained fatty tissue and showed an abundant mitotic activity (Figure 4).
Negative CK7 stain of the left mass.
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Immunohistochemistry (IHC) showed negative results for epithelial markers, such as cytokeratin 7 (CK7) (Figure 5) and epithelial membrane antigen (EMA), leukocyte common antigen (LCA), and desmin, which in turn excluded carcinoma origin, lymphoma/leukaemia, and muscular origin, respectively.
CD10-positive staining for the left mass suggesting stromal origin.
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fig6
Positive staining of CD10 (Figure 6) confirmed stromal origin confirming the diagnosis of high-grade stromal sarcoma of the breast.