PMC8586416_01
Comprehensive management protocol with the ATO-combined chemotherapy.  , ATO-combined chemotherapy with VAC regimen;  , VAC regimen; S, surgrey; RT, radiotherapy; ATO, arsenic trioxide; VAC, vincristine, actinomycin, and cyclophosphamide.
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ARMS patients under 18 years old without a major organ dysfunction. All patients received eight cycles of the ATO-combined chemotherapy incorporating comprehensive management according to the Intergroup Rhabdomyosarcoma Study Group protocol ( Figure 1 ).