PMC5465657_01
Red confluent patches and plaques involving the trunk and extremities, including the face, with mild periorbital and facial edema.
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A physical examination revealed cervical lymphadenopathy, splenomegaly, and sub-erythroderma (Fig. 1).
a, b Skin biopsy showing spongiotic dermatitis with perivascular lymphocytic infiltration with eosinophils.
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A skin biopsy, performed at presentation, revealed spongiotic dermatitis with perivascular lymphocytic infiltration with eosinophils (Fig. 2a). The patient was readmitted to our clinic, where another skin biopsy was performed, and the histological findings were similar to the previous ones, again in support of a drug reaction (Fig. 2b).