PMC3716244_01
Nests of malignant signet ring shaped adenocarcinoma cells in prostate. H and E; x100. (Inset: same signet ring cells with positive Alcian blue stain at pH 2.5.)
NJS-18-24-g001.jpg
PMC3716244_01_NJS-18-24-g001.jpg
F1
Histopathology revealed nests and singly infiltrating poorly differentiated, hyperchromatic, pleomorphic adenocarcinoma cells majority of which were of signet ring morphology [Figures 1-3]. The globoid optically clear cytoplasm of the signet ring cells were stained positively with Alcian blue at pH 2.5 confirming the contents as acid mucin [Figure 1 (inset)].
Signet ring cells lying haphazardly among bundles of smooth muscle fibers. H and E; x400
NJS-18-24-g002.jpg
PMC3716244_01_NJS-18-24-g002.jpg
F2
Histopathology revealed nests and singly infiltrating poorly differentiated, hyperchromatic, pleomorphic adenocarcinoma cells majority of which were of signet ring morphology [Figures 1-3].
Islands of signet ring cells. H and E; x400. (Inset: Tumour cells negative for PSA immunostain x100.)
NJS-18-24-g003.jpg
PMC3716244_01_NJS-18-24-g003.jpg
F3
Histopathology revealed nests and singly infiltrating poorly differentiated, hyperchromatic, pleomorphic adenocarcinoma cells majority of which were of signet ring morphology [Figures 1-3]. Initial diagnosis of signet ring variant of invasive prostatic adenocarcinoma with Gleason score 4+5=9 was thought of but IHC for PSA [Figure 3 (inset)] and Carcinoembryonic Antigen (CEA) were simultaneously performed as primary prostatic signet ring cell adenocarcinoma is rare and it is mandatory to exclude other mucinous tumors of non-prostatic origin based on morphology and immunohistochemistry and if necessary using clinical information.