PMC4918376_01
Low-power photomicrograph of patient's original glioblastoma showing pseudopalisading necrosis (A) and proliferative endothelium (B).. Note: Hematoxylin and eosin stain; x220.
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Neuropathologic examination revealed a GBM with an infiltrative glial tumor, with neoplastic astrocytes exhibiting nuclear pleomorphism and hyperchromatosis, along with elements of endothelial proliferation, necrosis, and pseudopalisading architecture (Figure 1A and B).
Axial, coronal, and sagittal T1 gadolinium enhanced magnetic resonance images before oncolytic HSV treatment (A-C) and at five year follow-up (D-F).. Abbreviations: 5yr F/U, 5-year follow-up; HSV, herpes simplex virus.
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The patient chose to participate in a Phase III study and was randomized to the standard treatment arm, not receiving any experimental therapy at that time (Figure 2A-F).
Photomicrograph of hematoxylin and eosin-stained representative tissue from 1998 (post-G207 treatment) resection, demonstrating areas of coagulative necrosis, perivascular inflammation, edema, astrocytosis, and foamy macrophages consistent with treatment effect.. Note: Atypical cells seen could represent inflammation, but tumor is not excluded; x200.
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Neuropathologic examination of the resected material identified areas of coagulative necrosis, perivascular inflammation, edema, astrocytosis, and foamy macrophages treatment effect (Figure 3).