PMC9949276_01
PMC9949276_02
abdominal computed tomography scan with retrograde contrast showing the tumour mass (arrow)
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F1
Abdominal pelvic computed tomography (CT) scan with retrograde contrast injection showed intensively vascularized mass sized 2x2 cm, positioned right to the bladder dome (Figure 1).
endoscopy view of the bladder mass (arrow)
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F2
Consequently, a tumour biopsy was performed (Figure 2).
pathologic examination of the biopsy specimen showed abundant extracellular mucin with clusters of tumour cells floating in mucin lakes
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F3
Histopathological analysis of excised specimen showed an infiltrative malignant epithelial neoplasm composed of atypical glandular structures with nuclear and cytological atypia, and in some foci, the presence of mucin production (Figure 3).
immunohistochemical staining (x40): A) positive CDX2, B) positive CK20
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F4
Immunohistochemical (IHC) analysis showed diffuse positivity for CDX2 and CK20 and partial positivity for CK7 (Figure 4).
intraoperative photo showing the removed specimen
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F5
IHC analysis could not exclude MCA (Figure 5). IHC showed CK20 and CDX2 expression, as in the biopsy specimen, the positivity of CK7 and Beta-catenin, and the focal expression of CA-125 (Figure 6).
immunohistochemical staining (x40): A) positive CK7, B) positive beta-catenin
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F6
IHC analysis could not exclude MCA (Figure 5). IHC showed CK20 and CDX2 expression, as in the biopsy specimen, the positivity of CK7 and Beta-catenin, and the focal expression of CA-125 (Figure 6).