PMC6477473_01
a Magnetic resonance imaging revealed that the liver tumors in the right and the caudal lobes were marginally enhanced on T1-weighted imaging after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid administration (Gd-EOB-DTPA), and the interior of the tumors revealed homogenous low-signal intensity. b Both liver tumors were hypointense on hepatobiliary phase images on Gd-EOB-DTPA. Arrows indicate the liver tumors.
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F1
T1-WI after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid administration (Gd-EOB-DTPA), and the interior of the tumors revealed a homogenous low-signal intensity (Fig. 1a). They were hypointense on hepatobiliary phase images on Gd-EOB-DTPA (Fig. 1b).
a Computed tomography revealed that the liver tumors in the right and the caudal lobes were marginally contrasted in high density in the early phase. b Both liver tumors were contrasted in iso-density in the late phase. Arrows indicate the liver tumors.
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F2
A dynamic computed tomography scan showed that both liver tumors were marginally contrasted in high density in the early phase and that they were contrasted in iso-density in the late phase, and the internal sites of both tumors showed low-density areas (Fig. 2a, b). [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) revealed not only focal
[18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography revealed not only focal FDG uptake in the liver tumors but also multiple focal FDG uptakes in bones. Arrows indicate focal FDG uptakes in bones.
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F3
FDG uptake in the liver tumors but also multiple focal FDG uptakes in bones (Fig. 3). From these findings, the liver tumors were suspected to be malignant tumors with cystic changes and bone metastasis.
a Hematoxylin and eosin staining showed that the liver tumor was composed of spindle cells with pleomorphic nuclei arranged into short fascicles. b The immunohistochemical staining for c-Kit was positive. c The immunohistochemical staining for DOG1 was positive. d The immunohistochemical staining for control was negative. Original magnification, x200.
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F4
Microscopic findings showed that the liver specimens were composed of spindle cells with pleomorphic nuclei arranged into short fascicles (Fig. 4a). The liver tumor immunohistochemical staining for c-Kit and for DOG1, as discovered on GIST, was positive (Fig. 4b, c).