PMC3037908_01
Radiological and pathological findings of lung cancer. A, Chest CT revealed a 15-mm nodular shadow in the left lower lobe. B, Histopathologically, the lesion was diagnosed as squamous cell carcinoma with stratification and keratinization.
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F1
In addition, he was found to have a 15-mm tumor with an irregular margin in the left S9 on chest computed tomography (CT), and was referred to our department (Figure 1A). Thus, the tumor was diagnosed as pT1aN0M0, stage IA (Figure 1B).
Histological findings of a pulmonary hilar lymph node. A, The lymph node exhibits residual nodal tissue and replacement by a vascular tumor (hematoxylin-eosin staining). B, The lesion is composed of well-developed capillaries. Organizing thrombi were identifiable (hematoxylin-eosin staining). C-D, Endothelial cells were positive for factor VIII and CD34 (C, Factor VIII immunostaining; D, CD34 immunostaining).
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F2
On the other hand, a lobar bronchial lymph node presented a lesion showing the dense proliferation of well-formed capillaries (Figure 2A, B). The stroma of the lesion showed small areas of fibrosis (Figure 2A). The lesion was well circumscribed and its borders sharply demarcated from the nodal lymphoid tissue (Figure 2A). There were organizing thrombi in many of the component capillaries (Figure 2B). Immunohistochemically, the lesion was positive for factor VIII, alpha-smooth muscle actin and CD34, and negative for D2-40, cytokeratin AE 1/3, and CD68, leading to a diagnosis of primary hemangioma of the lymph node (Figure 2C, D).