PMC9177095_01
Inflammatory left breast changes detected on CT scan (indicated by the white arrow).
cm-95-88f1.jpg
PMC9177095_01_cm-95-88f1.jpg
f1-cm-95-88
Bilateral ovarian masses were detected during a computed tomography (CT) together with inflammatory changes in the left breast (Figure 1).
A-D. Histological examinations of ovaries (A, B) and breast (C, D, E).
cm-95-88f2a.jpg
PMC9177095_01_cm-95-88f2a.jpg
f2a-cm-95-88
Immunohistochemical analysis showed positive staining for cytokeratin 7 (CK7), epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA) and negative for estrogen and progesterone receptors and Wilms tumor suppressor gene (WT1) (Figure 2, A and B). Progressively, the left breast inflammation worsened and a biopsy was performed which established signet ring cell infiltration (Figure 2 C,D,E). CSF cytology revealed 4 nucleated cells/mm3 with signet ring aspect, confirming the diagnosis of LMC (Figure 2F).