PMC5522915_01
Screening mammogram (a and b). (a) left breast - MLO. (b) left breast - CC. A new small circumscribed opacity is noted in the left breast at approximately 9 o'clock 10 cm from the nipple (arrows). Apart from a small normal appearing lymph node (marked A), no other new lesions were seen. [Reviewer Point 4]. (c) (Ultrasound) - A single targeted B-mode ultrasound image of the left breast with colour doppler assessment demonstrates a small solid avascular hypoechoic nodule with a tiny internal hyerechogenic foci. The lesion did not demonstrate any suspicious features, and correlates with the small circumscribed lesion noted on the mammography.
gr1.jpg
PMC5522915_01_gr1.jpg
fig0005
Mammograms obtained from the screening are as depicted [see Fig. 1a and b]. The ultrasonographic views of the corresponding lesion of interest are shown as follows [see Fig. 1c].
(a) This micrograph is taken at 400x magnification and is stained with haemotoxylin and eosin. It shows a sparsely cellular specimen with aggregates of lymphoid follicles and plasma cells. (b) [Reviewer Point 7]. Immunohistohemical staining for IgG4 demonstrates prominent IgG4-positive plasma cell infiltrates in the specimen. [Reviewer Point 7].
gr2.jpg
PMC5522915_01_gr2.jpg
fig0010
Microphotographs of the open biopsy specimen are as shown [see Fig. 2a and b].