PMC8130559_01
Clinical time course of clinical parameters in this subject. After emergency surgery, this patient underwent 6 courses of chemotherapy including capecitabine. After emergency surgery, she was treated with 500 mg of metformin for diabetes mellitus. In addition, through the chemotherapy including capecitabine, her plasma insulin level and LDL-cholesterol level were markedly elevated. And then, she was treated with 5 mg of rosuvastatin, one of the HMG-CoA reductases, for the treatment of dyslipidemia. Her plasma insulin and LDL-cholesterol level were markedly decreased.
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Furthermore, as shown in  Figure 1 , her hyperinsulinemia was markedly improved (plasma insulin, 13.5 muU/mL) compared to that during the chemotherapy (25.1-27.5 muM/mL), although plasma insulin level was still slightly higher compared to its reference range presumably due to overweight.