PMC9909398_01
(A) Axial CT without contrast in the cerebral window reveals craniopharyngiomas in the anterior, medial, and posterior fossa, with slightly high density in the anterior fossa, slightly low density in middle fossa, low density in the posterior fossa, and small high-density calcifications at the margins of middle fossa tumors. (B, C) The anterior, middle, and posterior cranial fossa tumors show multilocular cysts, the anterior cranial fossa tumor shows hyperintense on T1WI (B) and T2WI (C), and the middle and posterior cranial fossa tumors show equal signal on T1WI and T2WI. (D) MRA shows that the tumor in the posterior fossa surrounds the right vertebral artery. (E) FLAIR show mixed hyperintense in the anterior cranial fossa mass and hyperintense in the middle and posterior cranial fossa masses. (F) ADC does not show a restricted diffusion hypointense. (G) The sagittal T1WI shows no enhancement of the anterior cranial fossa tumor, wall enhancement of the middle and posterior cranial fossa tumors, and no enhancement in the center of all tumors. (H) Postoperative sagittal MRI showed that the tumor had been removed.
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F1
The tumor was slightly high density in the anterior cranial fossa, slightly high density in the middle cranial fossa with marginal discontinuous calcification, and low density in the posterior cranial fossa (Figure 1A), and there was no involvement of the bilateral cavernous sinuses. MRI images showed that the anterior cranial fossa mass was hyperintense on T1-weighted images (T1WI) and slightly hyperintense on T2-weighted images (T2WI), and the middle and posterior cranial fossa mass was hyperintense on both T1WI and T2WI images (Figures 1B, C). Magnetic resonance angiography (MRA) showed that the posterior cranial fossa mass wrapped around the right vertebral artery (Figure 1D). Fluid-attenuated inversion recovery (FLAIR) images showed that the anterior, middle, and posterior cranial fossa masses were all hyperintense (Figure 1E). There was no restricted diffusion low signal on ADC images (Figure 1F). The contrast-enhanced T1WI images showed no enhancement of the anterior cranial fossa mass wall and significant enhancement of the middle and posterior cranial fossa mass walls, with no enhancement in the center of all masses (Figure 1G). Postoperative MRI images showed that all tumors were removed (Figure 1H).
Histological and immunohistochemical features of craniopharyngioma.(A) A microscope shows adamantinomatous cells and keratins. (B-E) Immunohistochemical staining for CEA-,CK+,CK5/6+,GFAP- [Original magnification: (A) 200x;(B-E)100x].
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F2
Immunohistochemical staining was negative for CEA and GFAP but positive for CK and CK5/6 (Figure 2).