PMC6409830_01
Axial chest contrast-enhanced CT image showing the largest detected axillary lymph node measuring 4 cm in its greatest dimension (arrow).
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Her referral was preceded by evaluation for lymphadenopathy in the oncology clinic, including computed tomography (CT) scan (Fig. 1) and histological analysis of the excised left axillary lymph node (Fig. 2).
Light microscopy appearance of an excised lymph node transverse section showing altered general architecture due to presence of lymphoid cells of variable size and irregular shape arranged in follicle-like groups with lymphoid proliferation centers (arrowheads) and pseudogranulomas (arrows) (hematoxylin-eosin staining, 100 x).
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Histological examination revealed lymphatic node tissue with altered general architecture due to presence of lymphoid cells of variable size and irregular shape arranged in follicular groups with or without proliferation centers (Fig. 3).
Histopathologic findings in a lymph node consistent with specific granulomatous inflammation: pseudogranuloma (asterisk) with homogeneous structure surrounded by lymphohistiocytic infiltration (arrow) and a forming connective tissue pseudocapsule (arrowhead) (hematoxylin-eosin staining, 200 x).
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Attention was drawn by pseudogranulomas with homogeneous contents surrounded by lymphohistiocytic infiltration (Fig. 4) and a forming connective tissue pseudocapsule containing numerous macrophages (Fig. 5) indicative of specific granulomatous inflammation in lymph nodes.