PMC3690151_01
A firm nodule is present on the lateral aspect of the right upper lid (arrows).
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F1
The first patient was a 62-year old male with a painless, mobile mass of the right upper eyelid measuring 6x4 mm that had been enlarging over the course of three months (Figure 1).
Top. The tumor consists of ossified, calcified lamellar bone (arrows) that is beginning to develop a Haversian canal system (asterisks). Bottom. The lesion also contains an area of lymphoid hyperplasia consisting of follicles (*) surround by small, round lymphocytes. (hematoxylin-eosin, top, 25X, bottom, 100X).
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F2
The excised tissue consisted of a nodule of lamellar bone (Figure 2) adjacent to a lymphocytic infiltrate including follicles with germinal centers surrounded by mantle zones, scattered lymphocytes, plasma cells, and eosinophils.
PMC3690151_02
Top. The tarsal plate contains Meibomian glands (*) and is expanded by a nodule of lamellar bone (between arrows). Bottom. The bone exhibits osteoblastic rimming (arrowheads). (hematoxylin-eosin, top 5X, bottom 100X).
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F3
Histologic examination of the excised lesion showed nodular bone formation with osteoblastic rimming in the area of a sebaceous glands (Figure 3).