PMC6425374_01
There is global moderate mesangial siderosis and hypercellularity (periodic acid-Schiff, x400).
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fig1
Figures 1 and 2 are biopsies seen in light microscopy with the former showing mesangial proliferation and the latter demonstrating a crescent on silver stain.
Circumferential cellular crescent is present, associated with collapse of the underlying glomerular capillaries (methenamine silver, x400).
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fig2
Figures 1 and 2 are biopsies seen in light microscopy with the former showing mesangial proliferation and the latter demonstrating a crescent on silver stain.
Global 3+ mesangial deposit of immunoglobulin A is present (immunofluorescent, x 400).
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fig3
IgG of the glomerular basement membrane and mesangial sclerosis. Immunofluorescent staining positive for IgA and C3 is seen in Figures 3 and 4, respectively.
Global 3+ mesangial deposit of complement component C3 is present (immunofluorescent, x 400).
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fig4
IgG of the glomerular basement membrane and mesangial sclerosis. Immunofluorescent staining positive for IgA and C3 is seen in Figures 3 and 4, respectively.
There is no glomerular deposition of complement component C1q present (immunofluorescent, x 400).
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fig5
Staining for C4 and C1q was both negative with the latter seen on Figure 5.
There is mesangial hypercellularity and mild thickening of glomerular basement membrane along with electron dense deposits (ED) in mesangial, subendothelial, and subepithelial locations (electron microscopy, x 8000).
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fig6
In addition, electron microscopy showed uniform thickening of lamina densa of glomerular basement membrane, marked mesangial sclerosis, and hypercellularity, and some electron dense deposits were identified in the mesangial areas and subepithelial location which can be seen in Figures 6 and 7.
There are endocapillary cell hypercellularity and several small electron dense deposits within the glomerular basement membrane (electron microscopy, x 8000).
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fig7
In addition, electron microscopy showed uniform thickening of lamina densa of glomerular basement membrane, marked mesangial sclerosis, and hypercellularity, and some electron dense deposits were identified in the mesangial areas and subepithelial location which can be seen in Figures 6 and 7.