PMC9520566_01
Timeline of the major treatment process and CT evaluation of the patient since diagnosis. SD means "stable disease".
fimmu-13-998516-g001.jpg
PMC9520566_01_fimmu-13-998516-g001.jpg
f1
A 66-year-old man with stage IIIIC lung squamous cell carcinoma (SCC) (cT4N3M0) presented with cough and chest pain for four months ( Figure 1 ).
(A) 20 days after treatment ends, dyspnea, cough and fever occurred. (B) 27 days after treatment ends. (C) Radiation field.
fimmu-13-998516-g002.jpg
PMC9520566_01_fimmu-13-998516-g002.jpg
f2
The fourth cycle of treatment were synchronized with thoracic radiotherapy (TRT) (60 Gy/30 fractions), the mean lung dose (MLD) was 8.07 Gy, 22.5% of the lung received 20 Gy (V20), and 36% of the lung received 5 Gy (V5), which ended in Jan 2022 ( Figure 2C ). Computerized tomography (CT) of the chest showed the tumor was reduced in size and no pneumonitis was observed ( Figure 2A ). Only 3 days later, in the emergency department, CT was notable for extensive exudation of both lungs, diagnosis of interstitial pneumonia ( Figure 2B ).