PMC4022339_01
State transition diagram of the age-dependent Markov model that captures the disease condition dynamics for chlamydial infection and curing at discrete age point
i
= 0, 1, ...,
N
- 1.
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PMC4022339_01_2043-9113-4-7-2.jpg
F2
For the estimation, we first developed an age-dependent Markov state-transition model that depicts the disease condition dynamics for each female individual (Figure 2).
State transition diagram of the time-varying Markov model that captures the disease dynamics with first-time chlamydial infection, curing, and repeated infection. Note that the risks of chlamydial infection for the first time and repeated infection are different; and the sexual behaviors before and after the first-time infection are different as well.
2043-9113-4-7-3.jpg
PMC4022339_01_2043-9113-4-7-3.jpg
F3
We therefore extended the above Markov state-transition model (Figure 3).