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Distribution of aldosterone synthase (CYP11B2) and LHCGR in the patient's adrenal. (A), Distribution of CYP11B2 immunoreactivity in the tumor region (T) of the adrenal tissue. (B-E), Distribution of CYP11B2 (B, D) and LHCGR (C, E) immunoreactivities in consecutive sections of the APA tissue at low (B, C) and high (D, E) magnifications. Similar distribution of CYP11B2 and LHCGR immunoreactivities were observed in some areas (arrows) in (B, C). PT indicates peritumoral tissue; and V, vein.
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CYP11B2 staining in the adenoma confirmed aldosterone source from this adenoma without any positive adjacent nodular hyperplasia ( Figure 1 ). Complementary immunochemistry revealed positive LHCGR staining in small steroidogenic cells within the aldosteronoma ( Figure 1 ).
PMC10011616_04