PMC7690932_01
Pinkish/violaceous lesions being one located at the junction of the upper quadrants (A) and another at the junction of the lower quadrants measuring 0.5cm (B)
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On physical examination, the patient had two pinkish-violaceous lesions in the right breast, one that was mildly erythematous and almost imperceptible at the junction of the upper quadrants (UQJ) and another more intensely violet lesion at the junction of the lower quadrants (LQJ) measuring 0.5cm ( Figure 1 ).
Pathological anatomy
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Anatomic pathological report of the resected specimens showed a well-differentiated angiosarcoma (G1), a neoplasm characterized by anastomosing vascular ducts lined by atypical endothelial cells characterized by hyperchromatism and anisocariosis, sometimes containing red blood cells, arranged in an infiltrative growth pattern, permeating the mammary parenchyma and dermis ( Figure 2 ) at the UQJ measuring 1.9x1.4cm, and at the LQJ a neoplasm restricted to the dermis, measuring 1.1x0.5cm ( Figure 3 ).Immunohistochemical revealed positivity for the expression of cluster of differentiation 31 (CD31) and oncogene
Specimens obtained from skin lesions resected at the junction of the upper quadrants and junction of the lower quadrants of the right breast
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Anatomic pathological report of the resected specimens showed a well-differentiated angiosarcoma (G1), a neoplasm characterized by anastomosing vascular ducts lined by atypical endothelial cells characterized by hyperchromatism and anisocariosis, sometimes containing red blood cells, arranged in an infiltrative growth pattern, permeating the mammary parenchyma and dermis ( Figure 2 ) at the UQJ measuring 1.9x1.4cm, and at the LQJ a neoplasm restricted to the dermis, measuring 1.1x0.5cm ( Figure 3 ).Immunohistochemical revealed positivity for the expression of cluster of differentiation 31 (CD31) and oncogene
Immunohistochemical study showing positivity for (A) cluster of differentiation 31, and (B) oncogene C-MYC
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C-MYC (C-Myc), confirming malignancy secondary to radiation therapy ( Figure 4 ). Computed tomography of the chest and abdomen and bone scintigraphy showed no signs of distant metastases.