PMC8396390_01
trend in renal function relative to initiation of myeloma chemotherapy and COVID-19 infection; BM= bone marrow, Bx = biopsy
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F1
She was noted by her primary care physician to have progressively worsening renal function and elevated serum globulin levels over the previous year (Figure 1).
trend in serum free light chain levels and kappa-lambda free light chain (KL) ratios relative to initiation of myeloma chemotherapy and COVID-19 infection; KL ratios are shown above the bars; BM= bone marrow, Bx = biopsy
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F2
Serum free light chains were markedly elevated (Figure 2). Follow-up and outcomes: the patient was seen in the teleoncology clinic seven weeks later, where follow-up laboratory studies showed dramatic improvement in myeloma disease markers (Figure 2).
initial bone marrow biopsy at 20x magnification shows sheets of plasma cells highlighted with CD138 immunohistochemistry staining
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F3
CD138 + by immunohistochemical studies; and background normal hematopoietic cells (Figure 3, Figure 4). Cytogenetic studies showed 13q and 17p deletions, conferring high risk features.
initial bone marrow biopsy at 40x magnification showing sheets of plasma cells with hematoxylin and eosin staining
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F4
CD138 + by immunohistochemical studies; and background normal hematopoietic cells (Figure 3, Figure 4). Cytogenetic studies showed 13q and 17p deletions, conferring high risk features.
bone marrow biopsy after a single cycle of CyBorD and COVID-19 infection at 20X magnification demonstrating only scattered plasma cells on CD138 immunohistochemistry staining
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F5
She underwent another bone marrow biopsy, which showed normocellular bone marrow with the usual trilineage hematopoiesis (Figure 5, Figure 6).
bone marrow biopsy after a single cycle of CyBorD and COVID-19 infection at 20X magnification demonstrating trilineage hematopoiesis with hematoxylin and eosin staining
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F6
She underwent another bone marrow biopsy, which showed normocellular bone marrow with the usual trilineage hematopoiesis (Figure 5, Figure 6).