PMC4802527_01
Acute generalized exanthematous pustulosis. Erythematous and edematous eruption, with numerous pinpoint pustules on the dorsum of the hand.
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Physical examination found erythematous and edematous patches, with numerous nonfollicular pustules on the face, trunk, and extremities (Fig 1).
PMC4802527_02
Acute generalized exanthematous pustulosis. A skin biopsy shows a subcorneal pustule filled with neutrophils. Note the presence of necrotic keratinocytes in the epidermis. Papillary dermal edema and superficial mixed infiltrate composed of lymphocytes and neutrophils can also be seen. (Hematoxylin-eosin stain; original magnification: x200.)
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A skin biopsy found spongiform subcorneal and intraepidermal neutrophilic pustules along with papillary dermal edema, superficial lymphocytic infiltrate with neutrophils, and focal necrosis of keratinocytes (Fig 2).
Acute generalized exanthematous pustulosis. Typical superficial postpustular desquamation after 2 weeks.
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The patient was then treated symptomatically with topical corticosteroids and emollients, resulting in rapid resolution of the rash within 2 weeks followed by a postpustular desquamation (Fig 3).