PMC2663463_01
A) Association of lymphocytic angiitis and amyloid deposits infiltrating the wall of leptomeningeal vessel and perivascular cuffing of mononuclear cells (hematoxylin-eosin-safran original magnification X 10). B) Mononulear cells surrounding a non amyloid cortical vessel with severe intimal fibrosis occluding the lumen (hematoxylin-eosin-safran original magnification X 20). C) Amyloid deposits present in the senile plaques immunostained for bA4 (original magnification X 40). D) Amyloid deposits present in the wall of vessels in the neocortex immunostained for bA4 (original magnification X 40). E) Neurofibrillary tangles immunostained for tau protein (original magnification X 10). F) Giant cell arteritis in the myocardium (hematoxylin-eosin-safran original magnification X 40).
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Inflammatory infiltrates consisting in lymphoid cells and macrophages surrounded both amyloid and non amyloid vessels in the leptomeningeal space and less frequently in the cortex (Figure 1A). In addition, numerous vessels including some with amyloid deposition showed severe intimal fibrosis occluding the lumen, and suggesting a post inflammatory healing process (Figure 1B). Immunohistochemical study showed that amyloid deposits, present in the senile plaques and in the wall of vessels including some with an inflammatory infiltrate, were stained with betaA4 amyloid antigen (DAKO, Glostrup, Danemark) (Figure 1C, D). Tau protein filamentous accumulation was present within the cells bodies of neurons indicating the presence of neurofibrillary tangles, especially in the isocortex (Figure 1E). In the myocardium, the wall of a coronary artery was infiltrated by lymphocytes, mononuclear cells, and giant multinucleated cells (Figure 1F).