PMC10032165_01
The patient's CT scan of the chest during treatment. Chest CT at admission showed new patchy ground glass opacities in the right upper lung and right middle lobe (A). On day 36 after admission, the patient's condition deteriorated with new bilateral patchy infiltrates and a notable lung cavity (7 mm x 8 mm) in the anterior segment of the left upper lobe, though the primary ground glass opacity lesions in the right lung were resolved (B). The lung cavity lesion disappeared following 13 days of linezolid and 10 days of contezolid (C). After a nearly 4-month course of contezolid therapy, follow-up CT revealed that the lung cavity lesion and patchy infiltrations on both sides of the lung had disappeared entirely (D).
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C-reactive protein (CRP) 2.67 mg/dl; Procalcitonin (PCT) <0.05 ng/mL. CT scan of the lung showed new patchy ground glass opacities in the right upper lung and right middle lobe (Figure 1A). On day 36 after admission, the patient developed respiratory failure, and CT scan of the chest revealed new bilateral patchy infiltrates and a notable lung cavity (7 mm x 8 mm) in the anterior segment of the left upper lobe, though the primary ground glass opacity lesions in the right lung were resolved (Figure 1B). In addition, the cavitary lesion was also resolved, with decreased patchy infiltrations in the left upper lobe (Figure 1C). A follow-up CT scan performed after contezolid was discontinued revealed that the lung cavity lesion and patchy infiltrations on both sides of the lung had completely disappeared (Figure 1D).
Antibiotics used in the patient and correlated changes with the progress of the clinical condition.
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The patient was diagnosed with community acquired pneumonia at admission and received regular infection treatment with flomoxef and levofloxacin (Figure 2).   Considering that bacterial infections might also exist along with the viral infection, meropenem and tigecycline were prescribed for the patient (Figure 2). As a result, antibiotic treatment was switched to vancomycin and piperacillin/tazobactam for 13 days, but the patient's condition had not changed (Figure 2).