PMC4789394_01
CXR, PA view showing right-sided pleural effusion.
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Chest X-ray posteroanterior view (CXR, PA view) revealed right-sided pleural effusion (Figure 1).
CECT of thorax showing right-sided pleural effusion.
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Contrast enhanced computed tomography (CECT) of thorax showed only right-sided pleural effusion (Figure 2).
Microphotograph of histopathology of pleural biopsy tissue showing diffuse sheets of round to oval cells with hyperchromatic nuclei and scant to moderate amount of cytoplasm, focal spindle cells with hyperchromatic nuclei, and focal micropapillae formation, suggestive of a poorly differentiated malignant tumour (H&E stain, 40x).
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Focal micropapillae formation was also noted; features were suggestive of a poorly differentiated malignant tumour (Figure 3).
Microphotograph of immunohistochemistry showing tumour cells positive for synaptophysin (1) and occasionally for Ki-67 (2) and negative for CEA (3), CD 56 (4), calretinin (5), desmin (6), pan-cytokeratin (7), TTF1 (8), and WT1 (9) (40x).
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Immunohistochemistry of pleural tissue showed that majority of tumour cells were positive for synaptophysin and a few cells were positive for Ki-67 (2%) and negative for pan-cytokeratin, calretinin, Wilm's tumour protein 1 (WT1), desmin, vimentin, carcinoembryonic antigen (CEA), thyroid transcription factor 1 (TTF1), and CD 56 (Figure 4).