PMC8237854_01
Height and weight charts. Charts show growth deceleration from the 60th to 10th centile and a lack of weight gain from the age of 9.5 years.
fendo-12-645279-g001.jpg
PMC8237854_01_fendo-12-645279-g001.jpg
f1
She had not gained weight for 12 months prior to her admission ( Figure 1 ). At the same age, the proband had no signs of pubertal development and growth deceleration was seen, with a decrease from the 60th to 10th centile for height ( Figure 1 ).
Duodenal biopsies. (A) Hematoxylin and eosin staining shows normal duodenal mucosa without villous atrophy. (B) CgA immunostaining of the duodenal biopsy shows complete loss of EE cells. (C) Normal control duodenal mucosa immunostained with CgA, showing EE cell distribution in the crypt epithelium. (D) Repeated biopsy shows normal immunostained CgA duodenal mucosa.
fendo-12-645279-g002.jpg
PMC8237854_01_fendo-12-645279-g002.jpg
f2
AIE ( Figure 2 ).