PMC10451072_01
Skin lesions in case report 1. (A) Hyperpigmented and indurated cutaneous plaques inside both legs before treatment by Tocilizumab. (B) Hyperpigmented and indurated cutaneous plaques inside both legs 6 months after treatment by Tocilizumab. (C) Camptodactyly in the fifth radii.
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On clinical examination, hyperpigmented and indurated cutaneous plaques inside both legs and sparing knees were found ( Figures 1A, B ). A camptodactyly in the fifth radii of both hands ( Figure 1C ) and hallux valgus and retraction of the toes were noticed.
PMC10451072_02
(A) Thoracic scanner (parenchymal window) performed at the age of 4 during a new feverish episode and respiratory difficulties. Acute postero-superior lobar pneumonia measuring 34 mm with air bronchogram, right hilar adenomegaly and sequelar mediobasal and posterobasal atelectasis. (B) Height growth chart. Moderate effect of growth hormone and Tocilizumab on the height. (C, D) Large areas of pigmentation of the lumbosacral region and both lower limbs with associated hypertrichosis.
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From the first months of her life, she suffered from numerous febrile attacks and recurrent respiratory tract infections that required several hospitalizations ( Figure 2A ). She has been supplemented with GH since the age of 18 months with moderate growth improvement ( Figure 2B ). The buttocks, knees, and popliteal fossae were spared ( Figures 2C, D ).