PMC7192282_01
The first ACC arising in the left parotid gland. A solid-nodular growth pattern of the neoplastic epithelium. The tumor cell population resembles normal serous acinar salivary gland cells (hematoxylin & eosin, 40x).
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F1
Histology of the resected tumor confirmed a low-grade ACC with the neoplastic cell population predominantly arranged in solid-lobular pattern and surrounded by a dense lymphoid stroma containing the lymphoid follicles (Fig. 1).
PAS staining (the case presented in Figure 1). A multilobular microarchitecture of tumor tissue. The eosinophilic material in the cytoplasm of the neoplastic cells shows a strong purple color (20x).
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F2
Tumor cells contained PAS (Periodic Acid-Schiff) positive (Fig. 2) and diastase-resistant intracytoplasmic granules.
The second ACC arising in the right parotid gland. The tumor has the same microscopic appearanceas in the previous case (hematoxylin & eosin, 100x).
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F3
Histology confirmed a low-grade ACC showing the same picture as it was found in the left parotid gland (Fig. 3).
PAS diastase staining (the case presented in Figure 3). Purple color of the neoplastic cells does persist after digestion with a diastase (100x).
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F4
Neoplastic cells contained abundant PAS-positive, diastase-resistant cytoplasmic granules (Fig. 4).