PMC3586992_01
Fundus photo of the left eye demonstrates extensive retinal necrosis with intraretinal hemorrhage, overlying vitreitis (long arrows) and focal beading in multiple retinal veins (short arrows).
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F1
Funduscopic examination revealed extensive retinal necrosis and diffuse hemorrhages with multiple areas of focal venous beading (Fig.1), consistent with acute retinal necrosis.
Cross-sections of the temporal artery showed mild intimal thickening (short arrows) and an intact internal elastic lamina (long arrow) (A, H&E; B, Van Gieson stain, respectively; magnification 100X). Hyalinazation of vasa vasorum arterioles was noted (C, long arrows), consistent with diabetic vasculopathy. No evidence of inflammation was noted, particularly in the adventitial connective tissue or in association with vasa vasorum or vasa nervosum structures (H&E, magnification 400X. CD45 immunohistochemistry, as previously described, confirmed the absence of an inflammatory cell infiltrate (not shown).
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F2
Histological examination was normal (Fig. 2) while immunohistochemical analysis demonstrated VZV antigen in the arterial adventitia; evaluation of adjacent sections for HSV-1 antigen and infiltrating leukocytes (CD45, not shown) was negative (Fig. 3).