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Graph of VNS adjustment vs. SDB in 3 patients. The graph shows dose-dependent effects of VNS current (mA) on SDB as shown on Table 2. On the horizontal axis VNS settings are listed in mA, and on the vertical axis, SDB is quantified by the AHI (#/hr). Note the VNS-induced SDB decreased and disappeared when VNS was adjusted from initial settings to 0 mAs in 3 subjects.
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In 3 subjects who had their VNS adjusted, SDB decreased in a dose-dependent manner, as summarized in Fig. 1.
PSG showing VNS-induced SDB. Example of artifact in the EKG lead during VNS activation (red arrow) and induced apnea (red circle) followed by hyperpnea.
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Position had no impact on VNS AHI in any of the four subjects studied. (See Fig. 2.) (See Table 1.)