PMC7217256_01
Imaging data in a chronic granulomatosis disease patient with invasive aspergillosis caused by Aspergillus nidulans; a) a plain X-ray revealing the laminectomy of L4-L5 with pedicular screw, along with post-operative changes, and exhibiting a destructive soft tissue density mass lesion centered on the body of T4-T5 vertebrae with adjacent prevertebral soft tissue formation mostly in the right side leading to central spinal column involvement and right fifth rib destruction, b) a computed tomography scan revealing brain abscess leading to hydrocephaly, showing extensive vasogenic edema in the right tempoparietal lobe, along with the dilations of the left ventricle and occipital horn of the right ventricle
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F1
L4-L5 with pedicular screw, along with post-operative changes (Figure 1). Laboratory findings included ESR of 75 mm/h, CRP of 69, white blood cell count of 6000/mm3, monocyte of 37.4%, hemoglobin of 7.8 g/dl, and thrombocyte of 383000/mm3. However, it revealed the dilation of the left ventricle and dilation of the occipital horn of the right ventricle, along with extensive vasogenic edema in the right temporoparietal lobe (Figure 1). 
Microscopic image of Aspergillus nidulans isolated from the case; a) A.
nidulans colonies on Czapek-Dox medium, b) Observation of conidial head structure of A. nidulans stained with Lactophenol Cotton Blue under light microscope (40X magnification), c) smooth round hull cell
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F2
The results of histopathology and fungal culture obtained from surgical debridement samples revealed the diagnosis of invasive aspergillosis caused by Aspergillus species (Figure 2). In addition, a microscopic examination showed abundant hull cells and the conidial head pattern of A. nidulans (Figure 2).