PMC3362849_01
Preoperative MRI showing the left femur of a 76-year-old Caucasian female with diagnosis dedifferentiated chondrosarcoma (a) anterior-posterior axial view, (b) anterior-posterior front view.
CRIM2012-107894.001.jpg
PMC3362849_01_CRIM2012-107894.001.jpg
fig1
Imaging features were very typical of a primary bone tumor and thus, as tentative diagnosis chondrosarcoma was made by the reporting radiologist (Figure 1).
(a) Biopsy specimen of the proximal left femur of a 76-year-old Caucasian female with diagnosis dedifferentiated chondrosarcoma (400x), H.E. (b) same patient, clear-cell renal cell carcinoma of the right kidney (400x), H.E.
CRIM2012-107894.002.jpg
PMC3362849_01_CRIM2012-107894.002.jpg
fig2
Biopsy specimen of the proximal left femur revealed a biphasic tumor composed of a cartilaginous component with abrupt transition into a noncartilaginous malignant mesenchymal component (Figure 2). During the further course of treatment, the suspicious condition in the right kidney, that had already been present during initial tumor staging prior to limb salvage surgery, was diagnosed as clear-cell renal cell carcinoma (Figure 2) and immediately subjected to nephrectomy.
PMC3362849_02
Pedigree of the family presented, RCC: renal cell carcinoma, CHS: chondrosarcoma, OS: osteosarcoma, BL: urothelial carcinoma of the bladder.
CRIM2012-107894.003.jpg
PMC3362849_02_CRIM2012-107894.003.jpg
fig3
However, her medical family history (Figure 3) revealed that her youngest brother started suffering from invasive medium- to-low differentiated urothelial carcinoma (Figure 4) of the bladder when he was 67-year-old.
(a) Biopsy specimen of the proximal left femur of a 69-year-old Caucasian male with diagnosis fibroblastic osteosarcoma (200x), H.E. (b) same patient, invasive medium- to-low differentiated urothelial carcinoma of the bladder (400x), H.E.
CRIM2012-107894.004.jpg
PMC3362849_02_CRIM2012-107894.004.jpg
fig4
However, her medical family history (Figure 3) revealed that her youngest brother started suffering from invasive medium- to-low differentiated urothelial carcinoma (Figure 4) of the bladder when he was 67-year-old. He died at age 69 of a fibroblastic osteosarcoma (Figure 4) located in his left femur.