PMC4780511_01
(A, C, E) Fundus photographs (A), FFA (C) and OCT (E) images of patient at the first examination.
Fundus photographs, a centrally located DPED are seen with diffuse coalesced soft drusen at right eye. Hyperfluorescence of FFA and hypo-reflectivity of OCT correspond to CNV with a DPED.
(B, D, F) Fundus photographs (B), FFA (D) and OCT (F) images of patient after ranibizumab injections.
After 5 intravitreal ranibizumab injections, six months later, DPED at foveal area and drusen located superotemporal to macula are diminished over time. The late-phase fluorescein study shows regression of CNV.
TOOPHTJ-10-1_F1.jpg
PMC4780511_01_TOOPHTJ-10-1_F1.jpg
F1
DPED (Figs. 1A, 1C, 1E, 2A and 2E). DPED area was identified by FFA. DPED located temporal to macula is diminished. Drusen at superotemporal is diminished over time as well (Figs. 1B, 1F, 2B and 2F). CNV was regressed (Fig. 1D) and BCVA of 20/40 improved to 20/25 after 6 months from the initial examination.
(A, E) Initial examination, fundus photography and red free fundus image in the right eye revealed DPED (white dotted line) with diffuse coalesced soft drusen (black dotted line) at macular and paramacular region. There are focal hyperpigmentary changes and retinal hemorrhage (black arrowhead) over confluent drusen. 
(B, F) Six months after 5 intravitreal ranibizumab injections in the right eye, DPED at foveal area and drusens located superotemporal to macula are diminished over time. Retinal hemorrhage have also disappeared.
(C, G) One month after the initial absorption of drusen and DPED, drusen and central DPED reduction continued.
(D, H) Two months after initial absorption of drusen and DPED, previous central DPED reduction continued, and drusen at the superotemporal to macula area was decreased. But, CNV was recurred.
TOOPHTJ-10-1_F2.jpg
PMC4780511_01_TOOPHTJ-10-1_F2.jpg
F2
DPED (Figs. 1A, 1C, 1E, 2A and 2E). DPED area was identified by FFA. DPED located temporal to macula is diminished. Drusen at superotemporal is diminished over time as well (Figs. 1B, 1F, 2B and 2F). Reduction of drusen and DPED has continued up to 2 months after initial diminishment (Figs. 2C, 2G). After 2 months, CNV was recurred (Figs. 2D, 2H).