PMC4913178_01
(A) Magnification views in the CC. (B) Lateral projections of the right breast (upper outer quadrant) demonstrate a focal asymmetric density with architectural distortion associated to round and amorphous calcifications. (C, D) Sonographic image of the right breast demonstrates 8.6 mm mixed echogenicity irregular mass at the 9:30 position, approximately 4 cm from the nipple.
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Right axillary ultrasound showed multiple hipoechoechic lymph nodes with focal cortex enlargement (Fig. 1).
(A) On panoramic view the tumor is composed of multiple groups of neoplastic cells immerse on extracellular mucin within a fibrotic stroma (hematoxylin-eosin, original magnification x25). (B) Extracellular mucin lakes with are the prominent characteristic of the tumor. (C, D) Other areas of the tumor show the classic pattern of lobular carcinoma with single cell infiltration.
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The microscope exam of this area showed a dense fibrotic stroma with multiple extracellular mucin lakes of small diameter (Fig. 2A, B). At last, other areas of the tumor consisted of classic lobular invasive carcinoma, with single cell infiltration (Fig. 2C, D).
(A) ER was positive with a combined score of Allred of 7 (proportion 5, intensity 2) (B) PR was positive in the 90% of the cells. (C) Her2-neu negative. (D) E- cadherin negative, with internal control positive.
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Allred of 7 (proportion 5, intensity 2), progesterone receptors was positive in the 90% of the cells and Her2-neu and e-cadherin were negatives (Fig. 3). All margins were negative for in situ or invasive carcinoma.