PMC8733157_01
ECG changes. Before programmed cell death receptor 1 (PD-1) inhibitor treatment (sinus 104 bpm, normal QRS of 106 ms) (A); on admission (sinus 73 bpm, wide QRS of 156 ms, left bundle branch block) (B); at discharge (sinus 125 bpm, normal QRS of 118 ms) (C); at 6-month follow-up (sinus 113 bpm, normal QRS of 110 ms) (D).
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F1
Within a few days after the treatment, his symptoms significantly improved, while the LV reduced to a normal size and the QRS complexes resumed a normal morphology (Figures 1A-D).
The chronological changes of major parameters. CK, creatine kinase; HIG, human immunoglobulin; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; MG, methylprednisolone; NT-proBNP, N-terminal pro-brain natriuretic peptide; TnT, troponin-T; WBC, white blood cell count. *Normal ranges in parentheses.
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F2
The chronological changes in biomarkers and LV parameters with immunosuppressive treatment are shown in Figure 2.