PMC5892317_01
OCT-A imaging of foveal neovascularization (NVF). a Superficial plexus, where the lesion is located. b Deep retina plexus, which shows no sign of neovascularization. c Blood flow topographic map. d OCT B-scan, showing NVF as a uniform mass of moderate reflectance underneath the internal limiting membrane. e Color fundus image, showing multiple microaneurysms, dot and blot hemorrhages, and several hard exudates.
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F1
Fundus examination revealed multiple microaneurysms, dot and blot hemorrhages, and several hard exudates in the macula of both eyes (Fig. 1e). Due to patient's poor visual acuity and eye motion the image generated demonstrated several displacement and white line artefacts (Fig. 1a, b).
Fluorescein angiography reveals typical leakage of the dye due to retinal neovascularization both in early (left) and late phases (right).
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F2
Fluorescein angiography showed late leakage of the dye due to the existing microaneurysms and extensive capillary nonperfusion areas in the fundus, but no sign of leakage due to retinal neovascularization on the optic disc or along the vascular arcades (Fig. 2).
Processed images where displacement artefacts have been corrected. Superficial plexus slab (upper row), where it is evident that the neovascularization (inside yellow oval) emanates from superficial perifoveal capillaries. Blood flow topographic maps (lower row) indicating low blood flow in the perifoveal area and high blood flow in the neovascular lesion.
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F3
Image processing was performed in order to correct these artefacts (Fig. 3).