PMC2685913_01
Serial CT scans show variable response in retroperitoneal mass (arrowhead), multiple nodules of left hepatic lobe and two nodules (arrows) of right posterior lobe. (a) At initial presentation, (b) after one cycle of weekly paclitaxel, (c) after two cycles of doxorubicin, (d) after 3 months of sunitinib.
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fig1
After one cycle of paclitaxel, a CT scan (Figure 1(b)) revealed an increase in size of the three hepatic nodules and multiple new hepatic metastases. In a follow-up CT scan (Figure 1(c)), the diameter of retroperitoneal mass was somewhat increased from 12.8 cm to 13.9 cm. To evaluate any antitumor activity on the two hepatic masses, gross tumor volume was measured on serial CT scans (Figure 1) and the volume doubling times (VDT) between each chemotherapy regime were calculated, using the equation: VDT = [t x log 2]/log [V t/V o], where t is the interval in days between two scans, and V o and V t are tumor volumes at the previous and current examination, respectively.