PMC6335539_01
Multi-modal imaging profile of the DLB case.. Structural MRI revealed moderate hippocampal atrophy and on FLAIR minimal WML burden. [11C]-PiB binding showed a stereotypical AD-like pattern characterized by diffuse binding, particularly within the precuneus and frontal cortices. The topographic distribution of [18F]-AV1451 binding was atypical of AD, characterized with selectively higher uptake in the occipital cortices, paralleling with the distribution observed on the [11C]-PK11195 scan. The topography of [18F]-AV1451 binding showed an atypical pattern of occipital dominance. [18F]-AV1451 binding strongly overlapped with that of [11C]-PK11195 (r = 0.6, p < 0.001). Moreover, this spatial relationship was independent of [11C]-PiB binding. Abbreviations: MRI = Magnetic Resonance Imaging; FLAIR = Fluid-attenuated inversion recovery; PIB = [11C]-Pittsburgh Compound B; AV = [18F]-AV1451; PK = [11C]-PK11995.
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Intriguingly, we also noted a striking co-localization between [11C]-PK11195 and [18F]-AV1451 uptake, particularly in the occipital cortex (r=0.6, p<0.001; Figure 1).