PMC9971717_01
CT images of the 53-year-old female patient. (A) Tumor lesions of size 4.9 x 3.6 cm (red circle) and 7 x 6 cm (white circle). (B) Post-operative CT image before the first cycle of the GS regimen. (C) CT image post-chemotherapy after the second cycle of the GS regimen. (D) CT evaluation post-chemotherapy after the fifth cycle of the GS regimen. (E) CT evaluation post-chemotherapy after the sixth cycle.
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She underwent a CT scan ( Figure 1 ), which revealed multiple lesions in the left lobe of the liver, the left ovarian region, and the intraperitoneal region above the spleen.
PMC9971717_02
CT images of the 41-year-old male patient. (A) First diagnostic CT image showing tumor lesion (red circle) of size 3.0 x 2.8 cm taken in 2015. (B) CT image post-operation and after the first cycle of the GS regimen; no signs of tumor recurrence or metastasis. (C) CT image after the second cycle of the GS regimen. (D) CT image after the fourth cycle of the GS regimen. (E) CT image after the sixth cycle of the GS regimen. (F) CT image taken on follow-up in 2022.
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China Hospital due to a left hepatic mass found during physical examination. CT scan revealed a low-density shadow of approximately 3.0 cm x 2.8 cm in the left lateral lobe ( Figure 2 ), with unclear boundaries, irregular shape, and uneven edges seen on enhancement.
The Histologic features of the LELCC. (A) Hematoxylin - eosin staining (HE, 200x) shows poorly differentiated bile duct cells (Green) with lymphocytic infiltrates (Red). Immunohistochemically (200x), the tumor cells showed (B) CK7 and (C) CK19 expression, while no expression of (D) TTF1, (E) CK20 or (F) CDX2 (200x).
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Immunohistochemical staining results showed the following: tumor cells CK7 (+), CK19 (+), caudal related homeobox (CDX2) (-), thyroid transcription factor (TTF-1) (-), CK20 (-) ( Figure 3 ), and in situ hybridization of EBV-encoded RNA 1 or 2 (EBV-encoded RNA 1/2, EBER1/2) (-); it was considered to be EBV-negative LELCC.