PMC5301086_01
The fundus and the OCT during the initial patient diagnosis. a The patient's right eye: massive subretinal hemorrhage can be seen around the optic disc with macular involvement accompanied by vitreous hemorrhage. b Subretinal fluid (arrow) and macular edema are visible; the central retinal thickness increased to 436 mum.
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F1
Although the resolution was poor due to vitreous hemorrhage, optical coherence tomography (OCT) revealed a hint of macular edema with subretinal fluid with a central retinal thickness of 436 mum (Fig. 1).
a After 2 times intravitreal injection (IVI) of SF6, subretinal hemorrhage in the fundus has diminished significantly. The scar resulting from the choroidal rupture can be seen (arrow); a large amount of hemorrhage is still visible surrounding the scar, and vitreous hemorrhages decreased slightly compared to before. b OCT after the first IVI of SF6: macular edema has improved significantly, only some subretinal fluid is visible on the temporal side of the fovea. The scar from the choroidal rupture (arrow) can be seen; central retinal thickness has reduced to 278 mum. c After the second IVI of SF6, no significant changes can be observed in the fundus; subretinal and vitreous hemorrhage is still visible around the scar. Central retinal thickness in OCT has slightly increased to 319 mum.
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F2
One week after the injection, visual acuity of the right eye had improved to 0.03, but the subretinal hemorrhage and the vitreous hemorrhage conditions had not improved at all (Fig. 2), while the central retinal thickness had slightly increased to 319 mum.
a After the intravitreal injection (IVI) of Avastin, the scar from the choroidal rupture can be observed at the temporal side of the macular area; subretinal and vitreous hemorrhage has nearly disappeared. b After the IVI of Avastin, the subretinal fluid disappeared entirely; CRT is 210 mum, and macular edema is absent. c Early phase of fluorescein angiography after the IVI of Avastin. d Late phase of fluorescein angiography after the IVI of Avastin; obvious dye leakage cannot be observed.
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F3
The location of the choroidal rupture was observed on fluorescein angiography, and dye leakage was not observed during the early or late phase (Fig. 3).