PMC9478576_01
Photographs of the skin condition of Case 1. (A,B) Severe systemic erythema, edema, and urticaria at presentation. (C,D) One week after treatment initiation, erythema and edema disappeared. (E) Pulmonary interstitial infiltration and right-side cardiomegaly at the presentation on X-ray. (F) One week later, after treatment initiation, the infiltration of the lung disappeared.
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F1
Severe and generalized erythema, edema, and urticaria were also presented (Figures 1A,B). An X-ray showed right side cardiomegaly, pulmonary infiltration, moderate hepatomegaly (Figure 1E) and moderated dilation of the caudal vena cava and hepatic veins were noted on ultrasonography. After 1 week, the edema, erythema, and urticaria disappeared (Figures 1C,D). Proteinuria and pulmonary infiltration also disappeared (Figure 1F).
Histopathology (H&E staining) and cytology (Diff quick staining) of the [(A,B): Case 1]. (A) Marked edema with diffuse inflammation in the dermis(40x); (B) High magnitude of (A). Inflammatory cells (neutrophils, mast cells, and macrophages) are infiltrated in the edematous dermis (400x); [(C,D): Case 2] (A) Epidermal necrosis and separation of the epidermis and dermis (40x); (D) Infiltration of the inflammatory cells (neutrophils, macrophages) in separated interface sites (200x); [(E-H): Case 3] (E) Crusts and intact pustules (dot circle) on the abdomen; (F) Acantholytic cells (black arrows) and numerous neutrophils on the cytology of the pustules (400x); (G) Pustules in the hyperplastic stratum corneum in histopathology (40x); (H) Acantholytic cells (yellow arrows) that are surrounded by inflammatory cells (neutrophils, macrophages) in pustule (200x).
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F4
Some pustules and epidermal collarettes were also noted on the abdomen (Figure 4E). Meanwhile, there were numerous acantholytic cells surrounding inflammatory cells (neutrophils, macrophages) in the pustule on cytology (Figure 4F). Histopathology showed pustules containing numerous acantholytic cells in the stratum corneum similar to those observed in cytology (Figures 4G,H).
PMC9478576_02
Photographs of the skin condition of Case 2. (A,B) Systemic ulcerative patchy lesions at presentation. (C,D) 10 days later, after treatment initiation, the lesions were mostly improved.
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F2
C), generalized patchy ulcerative lesions, and erythema around the skin lesions (Figures 2A,B). Complete blood cell count showed thrombocytopenia. After 10 days, the patient's appetite and vitality, and the skin lesions were significantly improved (Figures 2C,D).
Histopathology (H&E staining) and cytology (Diff quick staining) of the [(A,B): Case 1]. (A) Marked edema with diffuse inflammation in the dermis(40x); (B) High magnitude of (A). Inflammatory cells (neutrophils, mast cells, and macrophages) are infiltrated in the edematous dermis (400x); [(C,D): Case 2] (A) Epidermal necrosis and separation of the epidermis and dermis (40x); (D) Infiltration of the inflammatory cells (neutrophils, macrophages) in separated interface sites (200x); [(E-H): Case 3] (E) Crusts and intact pustules (dot circle) on the abdomen; (F) Acantholytic cells (black arrows) and numerous neutrophils on the cytology of the pustules (400x); (G) Pustules in the hyperplastic stratum corneum in histopathology (40x); (H) Acantholytic cells (yellow arrows) that are surrounded by inflammatory cells (neutrophils, macrophages) in pustule (200x).
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F4
Some pustules and epidermal collarettes were also noted on the abdomen (Figure 4E). Meanwhile, there were numerous acantholytic cells surrounding inflammatory cells (neutrophils, macrophages) in the pustule on cytology (Figure 4F). Histopathology showed pustules containing numerous acantholytic cells in the stratum corneum similar to those observed in cytology (Figures 4G,H).
PMC9478576_03
Photographs of the skin condition of Case 3. (A,B) Systemic alopecia and crusts at presentation. (C,D) 10 months later, after treatment, alopecia was significantly improved and the crusts disappeared.
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F3
On the physical examinations, severe generalized alopecia, crusts, and erythema were identified (Figures 3A,B). The dog was well managed by immunosuppressants for 10 months (Figures 3C,D).
Histopathology (H&E staining) and cytology (Diff quick staining) of the [(A,B): Case 1]. (A) Marked edema with diffuse inflammation in the dermis(40x); (B) High magnitude of (A). Inflammatory cells (neutrophils, mast cells, and macrophages) are infiltrated in the edematous dermis (400x); [(C,D): Case 2] (A) Epidermal necrosis and separation of the epidermis and dermis (40x); (D) Infiltration of the inflammatory cells (neutrophils, macrophages) in separated interface sites (200x); [(E-H): Case 3] (E) Crusts and intact pustules (dot circle) on the abdomen; (F) Acantholytic cells (black arrows) and numerous neutrophils on the cytology of the pustules (400x); (G) Pustules in the hyperplastic stratum corneum in histopathology (40x); (H) Acantholytic cells (yellow arrows) that are surrounded by inflammatory cells (neutrophils, macrophages) in pustule (200x).
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F4
Some pustules and epidermal collarettes were also noted on the abdomen (Figure 4E). Meanwhile, there were numerous acantholytic cells surrounding inflammatory cells (neutrophils, macrophages) in the pustule on cytology (Figure 4F). Histopathology showed pustules containing numerous acantholytic cells in the stratum corneum similar to those observed in cytology (Figures 4G,H).