PMC6503585_01
Case 1: (a, b) Initial diagnosis shows intractable ulcer of the perineum.
(c) Dermis and epidermis harvested from the groin area. (d) Micrografts
were injected into the ulcer area. (e) Buttocks: rapid contraction and
complete recovery after treatment. (f) Pubis: rapid contraction and
complete recovery.
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After a few days of wound cleansing at our department, the patient under general anesthesia underwent debridement and cleansing of ulcers in the perianal and left groin (Figure 1(a) and (b)). This was followed by a buried chip skin graft, and Rigenera procedure was performed using dermal micrografts (Figure 1(c) and (d)). Thereafter, the wound areas showed rapid contraction and epithelization (Figure 1(e) and (f)), and the patient was transferred back to the initial hospital in March for rehabilitation.
PMC6503585_02
Case 2: Ulcer of left hallux. (a) Image of ulcer. (b) X-ray control reported
bone destruction. (c, d) Intraoperative procedure with debridement and
micrografts injection. (e) Artificial dermis was sutured over the injected
area. (f) Complete recovery seen after approximately 1 month. (g, h) X-ray
control after 1 and 9 months from micrografts application.
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An ulceration was formed on the sole of the left hallux, and bone destruction was observed under X-ray inspection (Figure 2(a) and (b)). The day after, skin of the ulcer on the left hallux was resected in a spindle shape after administering conduction anesthesia, and a curettage was performed on the interphalangeal joint using Luer forceps, which was then cleansed with saline solution (Figure 2(c)). Dermal tissue was harvested from the left groin area, and dermal micrografts were obtained by Rigenera procedure (Figure 2(d)). The defective area of the bone and soft tissue was filled with AQUACEL  Ag, and artificial dermis was sutured over it (Figure 2(e)). At the same time, gradual reduction in the ulcer was confirmed (Figure 2(f)). We reported no significant difference after 1 month (Figure 2(g)), but after 9 months, we observed a bone regeneration in the hallux proximal phalanx (Figure 2(h)).