PMC5279082_01
Optical coherence tomography scan of the right eye at the first visit. Optical coherence tomography revealed a defect (wide transparent white arrow) from the ellipsoid zone to the RPE/Bruch's complex layer with a diameter of 360 mum, with a pigment disorder in adjacent areas from the external limiting membrane to RPE/Bruch's complex layer. The inset image at the bottom right corner shows the normal appearance of the macular region. RPE = retinal pigment epithelium.
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F1
There was a pigment disorder in the adjacent area from the external limiting membrane to the RPE/Bruch's complex layer (Fig. 1).
Color fundus photograph, fundus autofluorescence, fundus fluorescein angiography, visual field, and multifocal electroretinography images of the right eye at the first visit. The color fundus photograph demonstrated a light-yellow lesion with obscure boundaries at the inferior nasal region of the fovea (2A). Fundus autofluorescence revealed mottled hypofluorescence in the inferior nasal fovea (2B), consistent with fundus fluorescein angiography demonstrating mottled hyperfluorescence in the same location. There was no fluorescence leakage (2C). The visual field analysis was unremarkable (2D). P1 amplitudes in the 2 central concentric rings were reduced as assessed by multifocal electroretinography (2E).
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F2
P1 amplitudes in the 2 central concentric rings were reduced as assessed by multifocal electroretinography (Fig. 2).
Optical coherence tomography scans of the right eye during the follow-up. In follow up at 1 month (3A), 3 months (3B), and 7 months (3C), her optical coherence tomography scans demonstrated that the diameter of the defect gradually shrank from 313 mum to 274 mum to 232 mum, respectively. The pigment disorder abated. A small round lump of high signal appeared in the layer of outer segments of the photoreceptors. Ten months later, at the last visit (3D), a 152 mum residual defect could be observed in the interdigitation zone and RPE/Bruch's complex layer. RPE = retinal pigment epithelium.
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F3
All examination results returned to normal except for a 152 mum residual defect in the interdigitation zone and RPE/Bruch's complex layer in her OCT (Fig. 3).