PMC9957600_01
Gross appearance of the cutaneous secretory carcinoma lesion.
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FIG1
On presentation, the lesion was a round, raised, firm, and fixed papule measuring approximately 7 mm x 7 mm with an irregular but smooth surface (Figure 1).
Multi-cystic circumscribed tumor in the dermis at 4x magnification with colloid-like material in the center of spaces and areas of papillary architecture.
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FIG2
On histology, the tumor was fully circumscribed in the dermis and contained a multi-cystic and patchy micropapillary architecture (Figure 2).
Low-grade cytology and eosinophilic cytoplasm of tumor cells at 20x magnification.
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FIG3
There was variable mono- to multi-layered lining and bland-to-mildly enlarged cytology, with central prominent eosinophilic secretions, a common characteristic of secretory carcinoma (Figure 3).
(A) Diffuse staining on S100 immunostaining at 4x magnification. (B) Strong staining on SOX10 immunostaining at 4x magnification. (C) Strong expression of PanTRK protein at 10x magnification. (D) Absence of myoepithelial cells on p40 stain at 10x magnification.
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FIG4
Immunostaining demonstrated strongly positive S100 staining (Figure 4A), a common characteristic of CSCs, MASCs, and SBCs. SOX10 (Figure 4B), gross cystic disease fluid protein (GCDFP), and estrogen receptor (ER) (about 20% of cells with variable intensity). Strong expression of PanTRK protein was also noted (Figure 4C). Myoepithelial cells were not visualized on smooth muscle actin, p40 (Figure 4D), and p63 stains.