PMC5313429_01
Chest computed tomography from the start of pazopanib therapy. (A) Lung metastases from leiomyosarcoma and (B) pre-existing interstitial lung disease are observed.
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Three months previously, the patient had been diagnosed with left femoral vein leiomyosarcoma, and a chest computed tomography (CT) scan revealed multiple pulmonary metastases with bilateral mild reticular shadows (Fig. 1).
The clinical course of the present case.
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The clinical course is shown in Fig. 2.
The radiological findings on admission are shown. (A) Chest radiography shows bilateral peripheral reticular shadows. Chest computed tomography demonstrates bilateral diffuse ground-glass opacity and the progression of traction bronchiectasis (B) on the day of admission, (C) partial improvement on the 8th day of treatment, and (D) recurrence of interstitial pneumonia on the 42nd day.
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Chest radiography and a CT scan showed partial improvement of the bilateral GGO (Fig. 3C), and he was transferred to another hospital on the 22nd day after admission. After tapering the patient's prednisolone dose on the 34th day of treatment, hypoxia and bilateral reticular shadows developed again (Fig. 3D).