PMC5394820_01
Computed tomography showing a primary tumor at the right side of the base of tongue measuring 3 cm x 2 cm x 1 cm
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F1
CT scan showed a growth on the right side of the base of tongue measuring 3 cm x 2 cm x 1 cm [Figure 1].
(a) Photomicrograph showing monomorphic tumor cells arranged in small clusters, nests, and sheets suggestive of neuroendocrine differentiation (H and E, x100), (b) tumor cells are seen invading the fibroconnective stroma (H and E, x200), (c) individual tumors cells are round with scant eosinophilic cytoplasm and round to oval hyperchromatic nucleus (H and E, x400), (d) photomicrograph showing tumor necrosis and crush artifact commonly seen in small cell neuroendocrine carcinoma (H and E, x200)
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F2
Abnormal mitotic figures (7-8/10 high power fields), necrosis, and crush artifact were also seen [Figure 2a-d].
Immunohistochemistry: Tumor cells demonstrating positivity for neuron-specific enolase (a), synaptophysin (b), chromogranin (c), and cytokeratin 7 (d) (immunostain x 200)
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F3
On immunohistochemistry, the tumor cells showed positivity for neuron-specific enolase, synaptophysin, chromogranin, pan-cytokeratin (CK), and CK7 [Figure 3a-d].