PMC5705894_01
Endoscopic image showing brown-black speckled spots throughout the mucosa of the duodenum (a) and gastric polyp (b).
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She underwent esophagogastroduodenoscopy showing hyperpigmented mucosa with black speckled spots throughout the mucosa in stomach and duodenum (Figure 1(a)). Endoscopy also showed four polyps, three of them in gastric body, largest being 1.2 cm in size (Figure 1(b)).
Hematoxylin and eosin stain (x400) of the gastric (a) and small intestinal mucosa (b) showing dark brown clumpy pigment present within histiocytes in lamina propria.
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The hematoxylin and eosin stain of the biopsy showed small intestinal and gastric oxyntic mucosa with dark brown clumpy pigment within histiocytes of the lamina propria (Figure 2).
Panel of two images; Prussian blue stain (x600) with blue pigment deposition confirming the presence of iron within histiocytes (a). And Fontana Masson stain (x600) of the small intestine with brown-black pigment deposition consistent with melanin or melanin-like substance deposition in the macrophages (b).
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Prussian blue stain was positive for iron depicted as blue deposition in the histiocytes and Fontana Masson staining showed brown-black pigment deposition consistent with melanin or melanin-like substance (Figure 3).