PMC10049844_01
Huge thymic tumor with superior vena cava infiltration on CECT-TAP in 2013 (prior surgery).
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A 61-year-old woman with a history of malignant thymoma was diagnosed in year 2013 with superior vena cava involvement (Masaoka-Koga staging III) (Figure 1).
No evidence of breast lesion seen on CECT-TAP in 2016.
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Three years after the surgery, surveillance imaging with contrast enhanced computed tomography (CECT) thorax showed increased lung nodules suspicious of metastasis in 2016 (Figure 2).
Mammogram of right breast showed well-circumscribed, round, high-density lesions at upper mid region and upper outer quadrants.
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Mammogram of bilateral breasts showed well-circumscribed, round, high-density lesions at upper mid region and upper outer quadrant of right breast (Figure 3).
On histology, the lesional tissue is composed of (a) and (b) tumour tissue arranged in anastomosing smooth contoured islands, Hematoxylin & Eosin stain (H&E) x40. (c) Absence of duct/glandular formation, H&E x100. (d) Tumour cells have round to oval nuclei, inconspicuous nucleoli, and indistinct cell membrane, H&E x400.
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Tissue core-biopsy of right breast 12 o'clock lump was performed, and histopathology examination came back as metastatic thymic carcinoma (Figure 4), p53, and CD5 positive for staining (Figure 5).
(a) Tumour cells show positive staining for p63 (x40). (b) CD5 shows patchy positive cells (x40).
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Tissue core-biopsy of right breast 12 o'clock lump was performed, and histopathology examination came back as metastatic thymic carcinoma (Figure 4), p53, and CD5 positive for staining (Figure 5).