PMC2799331_01
Arachidonic acid cascade initiated by cPLA2alpha. P450, cytochrome P450; LOX, lipoxygenase; COX, cyclooxygenase; HETE, hydroxyeicosatetraenoic acid; EET, epoxyeicosatrienoic acid.
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PMC2799331_01_nihms120759f1.jpg
F1
AA (Figure 1). A genetic deficiency of thromboxane synthase seemed unlikely due to the depressed biosynthesis of other prostanoids.