PMC6458917_01
Mammography demonstrates a stable oval, circumscribed mass in the medial part of the left breast.
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fig1
In mammography, a radiologic circumscribed, well-demarcated density, of her medial left breast without lymph node enlargement, was identified (Figure 1).
Macroscopic appearance of a well circumscribed, solid with subtle nodularity tumor, with central areas of necrosis.
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fig2
On gross examination, serial sectioning revealed a large solid, well circumscribed, lobulated, with subtle nodularity tumor, measuring 4,8X4X3,8cm, with central necrosis (Figure 2).
Histological appearance of infiltrative lesion (on the right) of the breast (on the left) composed of sheets of small round blue cells (Hematoxylin & eosin, original magnification X50).
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fig3
The final histopathological report showed an undifferentiated, high grade tumor of the "small round blue cell" morphology, suggestive of rhabdomyosarcoma (Figures 3-8).
Histological examination shows solid infiltration of small/intermediate neoplastic cells displaying round hyperchromatic pleomorphic nuclei with indistinct cytoplasm and brisk mitotic activity (Hematoxylin & eosin, original magnification X200).
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fig4
The final histopathological report showed an undifferentiated, high grade tumor of the "small round blue cell" morphology, suggestive of rhabdomyosarcoma (Figures 3-8).
Same as Figure 4, higher magnification.
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fig5
The final histopathological report showed an undifferentiated, high grade tumor of the "small round blue cell" morphology, suggestive of rhabdomyosarcoma (Figures 3-8).
Tumor cells grow in nests separated by hyalinized fibrous septa (X200, H&E stain).
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fig6
The final histopathological report showed an undifferentiated, high grade tumor of the "small round blue cell" morphology, suggestive of rhabdomyosarcoma (Figures 3-8).
Tumor cells with extensive necrosis (H&E, X200).
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fig7
The final histopathological report showed an undifferentiated, high grade tumor of the "small round blue cell" morphology, suggestive of rhabdomyosarcoma (Figures 3-8).
Alveolar pattern with necrosis (H&E, X200).
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fig8
The final histopathological report showed an undifferentiated, high grade tumor of the "small round blue cell" morphology, suggestive of rhabdomyosarcoma (Figures 3-8).
Immunohistochemistry shows positive cytoplasmic (dot-like) staining of the tumor cells for desmin (X200).
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fig9
Staining for desmin (Figure 9), myogenin (Figure 10), myoD1 (Figure 11), NF (Figure 12), and bcl-2 (Figure 13) confirmed the diagnosis of RMS (solid variant of alveolar type).
Immunohistochemistry shows positive nuclear staining of the tumor cells for myogenin (X100).
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fig10
Staining for desmin (Figure 9), myogenin (Figure 10), myoD1 (Figure 11), NF (Figure 12), and bcl-2 (Figure 13) confirmed the diagnosis of RMS (solid variant of alveolar type).
Immunohistochemistry shows positive nuclear staining of the tumor cells for myo-D1 (X200).
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fig11
Staining for desmin (Figure 9), myogenin (Figure 10), myoD1 (Figure 11), NF (Figure 12), and bcl-2 (Figure 13) confirmed the diagnosis of RMS (solid variant of alveolar type).
Immunohistochemistry shows positive cytoplasmic (dot-like) staining of the tumor cells for neurofilament (NF) (X100).
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fig12
Staining for desmin (Figure 9), myogenin (Figure 10), myoD1 (Figure 11), NF (Figure 12), and bcl-2 (Figure 13) confirmed the diagnosis of RMS (solid variant of alveolar type).
Immunohistochemistry shows positive cytoplasmic staining of the tumor cells for bcl-2 (X400).
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fig13
Staining for desmin (Figure 9), myogenin (Figure 10), myoD1 (Figure 11), NF (Figure 12), and bcl-2 (Figure 13) confirmed the diagnosis of RMS (solid variant of alveolar type).