PMC9742191_01
EEGs for this patients. (A) sharp waves and slow waves could be detected in each brain area which are predominant in anterior head lead. (B) EEG became normal during follow up.
fped-10-1019122-g001.jpg
PMC9742191_01_fped-10-1019122-g001.jpg
F1
EEGs re-examined at six months showed sharp waves and slow waves in each brain area, especially in the anterior head lead (Figure 1A). There were no epileptic seizures, and her EEG result was normal (Figure 1B).
ECG and point diagram of ICD cavity for this patient. (A) ERP could be detected on ECG: elevation of J-point in inferior leads (II, III, AVF) and lateral leads (V5, V6). (B) J wave amplitudes were decreased slightly after administration of oral quinidine. (C) Diagram of ICD cavity shows atrial arrhythmias with electrical shock and ventricular pacing administered by ICD. (D-F) Diagram of ICD cavity shows VF occurred and was terminated by electrical shock of ICD.
fped-10-1019122-g002.jpg
PMC9742191_01_fped-10-1019122-g002.jpg
F2
ECG showed ERP (Figure 2A), and a 24 h Holter monitor showed paroxysmal AF, premature atrial complexes (PACs), paired PACs and paroxysmal atrial tachycardia (AT). ICD recorded multiple episodes of inappropriate shocks during AT (ventricular rate 254-288 bpm) without syncope recurrence (Figure 2C). Adams-Stokes attack over an 8-day period. A diagram of the ICD cavity showed VF during Adams-Stokes syndrome and successful defibrillation by ICD (Figures 2D-F). ECG showed that the J wave amplitude decreased slightly (Figure 2B).
Results of KCND3 gene DNA sequencing patient has KCND3 chr 1-112524433 G306S (c.916G > A). Her parents and brother did not carry the same variant.
fped-10-1019122-g003.jpg
PMC9742191_01_fped-10-1019122-g003.jpg
F3
Whole-exome sequencing showed KCND3 chr 1-112524433 and G306S (c.916G > A) (Figure 3, Beijing Maijinuo Medical Laboratory).