PMC8298026_01
Chest CT of this patient. (A) Chest CT was obtained on February 6, 2020 (hospital day 3, illness day 5). Multiple patchy shadows, ground-glass opacity (GGO) under the pleura, streak-like density-increased shadows in the bilateral lungs were observed. (B) Chest CT was obtained on February 23, 2020 (day 21). The texture of the trachea and blood vessels in both lungs showed thickening. Both the GGO and patchy shadows increased, and the original was consolidated. (C) Chest CT was obtained on April 10, 2020 (day 68). The patchy lesions and consolidations in both lungs were absorbed, and the fiber shadows increased in size partially in the lower lung.
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F1
Chest CT examination was performed to evaluate the abnormal breath sounds, which revealed bilateral pneumonia (Figure 1A). Our continuous bedside monitoring of her vital signs showed a temperature fluctuation between 37.4 and 38.2 C, except inflammation-induced fever-like symptoms in the initial 2 days (Supplementary Figure 1). CBC test were consistent with those of the viral-infection ramification of high WBC count and low lymphocyte percentage. Chest CT scans from hospital day 20 showed a continuous lesion development in the bilateral lower lobe, with visible fibrosis and necrosis in the lung tissue (Figure 1B). CT scanning results with the previous showed partial absorption of bilateral patchy lesions in the lungs of the patient, yet accompanied by a great deal of GGO, non-homogeneous density, and air bronchus signs (Figure 1C). Considering the benefits of organ injury recovery caused by inflammatory responses, allogenic hUCMSCs were administrated intravenously for the second round three times (6.5 x 107 cells each time) on days 59, 63, and 66.
Chest CT of this patient. (A) CT images on day 78 indicate that patchy shadows and GGO increased in the right lower lung lobe but decreased in the left upper lung. (B) CT images on day 129 indicate that patchy shadows, GGO, and consolidations were absorbed, and some air bronchogram signs and fiber strands were left. (C) CT images on day 150 by follow-up indicate that the fiber strands were reduced, and GGO decreased gradually.
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F2
Most of the vital signs and clinical laboratory indexes recovered in the normal range, with certain recovery in the chest CT images as well (Figure 2). Long-term follow-up is currently ongoing to monitor changes in the lung lesion of the patient (Supplementary Figure 2).