PMC8053605_01
Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Immunohistochemical staining of H&E (A) and Ki67 (I), negative for CD20 (B) and positive for CD3 (C), CD21 (D), CD10 (E), Bcl-6 (F), CD4 (G), PD-1 (H) (A: H&Ex100, inset: H&Ex400, B-I: x200).
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T cell receptor gene rearrangement was positive but no clonal IgH gene rearrangement was detected (Figure 1). The patient was diagnosed with AITL, with a prognostic index for T-cell lymphoma (PIT) score of 3.
Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Immunohistochemical staining of H&E (A) and Ki67 (I), positive for CD20 (B), MUM1 (D), CD10 (E), Bcl-6 (F), EBER (G) and negative for CD3 (C), PD-1 (H) (A: H&Ex100, inset: H&Ex400, B-H: x200, I: x100).
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Immunohistochemical staining revealed that the diffuse infiltration of these abnormal medium-to-large-sized lymphocytes with prominent nucleoli was predominantly positive for Bcl-6, MUM1, CD20, CD21, CD10, EBER (>200/high-power field), and Ki67 (80%+), but negative for CD3, PD-1, CD8, CD4, CD5, CD7, and CXCL13 (Figure 2).
Comparison of positron emission tomography/computed tomography scans before and after lenalidomide-combination treatment.
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PET/CT scan demonstrated decreased FDG uptake in many parts of the body compared with before treatment (Figure 3).