PMC4644139_01
Clinical course. On hospital day 12, intravenous furosemide was terminated, while oral furosemide was continued with an increased dose of 300 mg/day, and the patient was discharged on hospital day 16. Note that the levels of BP and serum Cr (sCr) were almost constant during the observation period despite prominent elevation of the daily urine output after the commencement of oral dapagliflozin.
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She then received treatment with oral dapagliflozin at a dose of 5 mg/day on hospital day 5, which resulted in a remarkable increase in her urine volume as well as the amount of urinary excreted sodium and glucose, with the gradual disappearance of the generalized edema, despite the almost constant levels of her systolic and diastolic BP during the observation period (Fig. 1).