PMC6334586_01
(a) Retrograde urethrogram showing filling defects. (b) Intraoperative picture from urethrocystoscopy
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F1
A retrograde urethrogram revealed multiple irregularities along the wall of the anterior urethra [Figure 1a]. On urethrocystoscopy, there was a solid friable growth around 1 cm seen in the mid penile urethra [Figure 1b].
Photomicrograph composite - Carcinoma composed of hyperchromatic, blue cells with angulated nuclei, having marked crushing. The cells do not have appreciable cytoplasm and are packed closely, demonstrating faceting. Confluent necrosis is evident. (1: H and E, x10; 2: H and E, x20; 3: H and E, x40). Immunohistochemistry- (4: NSE, x40), (5: Synaptophysin, x40); (6: Ki67, x40)
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F2
The first microscopic examination revealed carcinoma cells with dense nuclear chromatin, indistinct nucleoli, and scant cytoplasm, suggesting a poorly differentiated carcinoma [Figure 2].