PMC6074278_01
(A) Erythema multiforme on the trunk, showing target lesions. (B) Peripheral blood morphology demonstrating atypical lymphocytes with irregular margins and abnormal granules (Wright-Giemsa, 100x). (C) Bone marrow biopsy showing increased plasma cell infiltration (hematoxylin and eosin, x400). (D) Bone marrow biopsy with plasma cells positive for CD138 arranged in a membranous pattern (CD 138 stain, x400).
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Physical examination revealed tenderness on the right upper quadrant area and erythema multiforme on his trunk (Figure 1A). Peripheral blood smears indicated normocytic normochromic anemia, monocytosis with atypical lymphocyte, moderate leukocytosis, and neutrophilia with toxic neutrophil changes (Figure 1B). Bone marrow biopsy revealed increased plasma cell infiltration (Figure 1C and 1D).