PMC6374790_01
MRI of distal left fibula (green arrow) and tibia (red arrow) showing multifocal chronic osteomyelitis.
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Magnetic resonant imaging (MRI) of the left lower limb confirmed the diagnosis of multifocal, chronic osteomyelitis involving the distal left fibula, lower part of both tibiae, and metatarsal bones of both feet (Figure 1).
Histopathology of descending colon biopsy, showing UC picture: distorted crypts (red arrow) with lamina propria chronic mononuclear inflammatory cells infiltrate (blue arrow) (H&E stain, x40).
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Hence, colonoscopy showed features of pancolitis with pseudopolyps in the entire colon; histology showed features of chronic active colitis, crypt architectural distortion, and absence of granuloma (Figure 2); terminal ileum (TI) was normal macroscopically and histologically; and magnetic resonance enterography (MRE) excluded small bowel disease.