PMC5385903_01
Precontrast axial (a), postcontrast axial (b), and postcontrast left parasagittal (c) T1-weighted MR images of the brain demonstrate an intra-axial left frontal mass with heterogeneous internal nodular and septal enhancement. The largest enhancing component is subjacent to markedly thinned medial left frontal cortex. T2-weighted axial images (d) demonstrate hyperintense cystic formation with near complete suppression on FLAIR sequences (e). No peritumoral T2 hyperintensity is present to suggest vasogenic edema or gliosis. Details from high-resolution, heavily T2-weighted images (f) redemonstrate mixed solid and cystic components and thin internal septation. No elevated perfusion or abnormally restricted diffusion was identified on MR perfusion or diffusion-weighted imaging, respectively (not shown).
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Magnetic resonance imaging (MRI) of the brain demonstrated a mixed cystic and solid, heterogeneously enhancing intra-axial mass centered within the left frontal lobe effacing the adjacent frontal horn of the lateral ventricle (Figure 1).
Photomicrographs of hematoxylin and eosin sections: (A) microcystic/reticular foci with a myxoid appearance adjacent to denser spindle cell areas (100x magnification); (B) microcystic areas with vacuolated cells; and (C) bland spindle cells with palisading configurations (B&C: 400x magnification).
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There was no necrosis, significant cytologic atypia, or mitoses (Figure 2).
Photomicrographs of immunohistochemical stains: (A) S-100 (400x): nuclear and cytoplasmic staining in tumor cells, (B) progesterone receptor (400x): focal staining and (B inset) estrogen receptor (100x): no staining in tumor, and (C) GFAP (400x) and (D) EMA (100x): negative staining in tumor.
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Thermo Scientific 4C4.9) in their nuclei and cytoplasm and had patchy staining with CD34 (QEnd/10) and calretinin (cal6) and focal staining with progesterone receptor (PR1294, Dako) immunostain. Tumor cells were negative for estrogen (ID5), EMA (E29, Dako), Bcl-2 (mouse monoclonal 124), CD10 (56C6, Thermo Scientific), inhibin (R1, Thermo Scientific), and GFAP (polyclonal, Dako) immunostains (Figure 3).