PMC9240352_01
Sampling days The mother was treated with 20 mg sildenafil three times daily and 125 bosentan twice daily for pulmonary arterial hypertension. She also took 25 microg/day Vitamin D3 (1000 IE) each morning and Ibuprofen (400 mg) on day 637 post-delivery at 14:30, but this is not expected to interfere with the studied medicines. Each expression session, the mother collected a sample from the expressed milk.
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F1
D3 25 microg (1000 IE, oral spray, Holland and Berrett) each morning and occasionally Ibuprofen (400 mg). Dosing and timing of medicines used are provided in Table 1 and Figure 1. A case report form was used to collect maternal variables and to record maternal medicine intake during 7 days prior to the two sampling days (Supplementary Figure S1). At both days, human milk was collected over 24 h, starting at the time of medicine intake (Figure 1).
PMC9240352_02