PMC8075656_01
Two synchronous neonatal tumors. (a) Newborn with facial and cervical mass. (b) Magnetic resonance imaging showing cervical multinodular mass and liver tumor. (c) Light microscopy shows sialoblastoma with nests of basaloid (epithelial) cells and a cribriform pattern (H&E, 20x HPF). (d) The proliferative index revealed an increased number of nuclei staining positively with Ki67 (clon Mib-1, immunohistochemistry, 40x HPF).
CRIPA2021-6674372.001.jpg
PMC8075656_03_CRIPA2021-6674372.001.jpg
fig1
Histology showed lobulated solid nests and microcystic areas (Figure 1(c)). The proliferation fraction index (Ki67) ranged from 20% to 30% in different areas (Figure 1(d)).
PMC8075656_02
Two synchronous neonatal tumors. (a) Newborn with facial and cervical mass. (b) Magnetic resonance imaging showing cervical multinodular mass and liver tumor. (c) Light microscopy shows sialoblastoma with nests of basaloid (epithelial) cells and a cribriform pattern (H&E, 20x HPF). (d) The proliferative index revealed an increased number of nuclei staining positively with Ki67 (clon Mib-1, immunohistochemistry, 40x HPF).
CRIPA2021-6674372.001.jpg
PMC8075656_03_CRIPA2021-6674372.001.jpg
fig1
Histology showed lobulated solid nests and microcystic areas (Figure 1(c)). The proliferation fraction index (Ki67) ranged from 20% to 30% in different areas (Figure 1(d)).
PMC8075656_03
Two synchronous neonatal tumors. (a) Newborn with facial and cervical mass. (b) Magnetic resonance imaging showing cervical multinodular mass and liver tumor. (c) Light microscopy shows sialoblastoma with nests of basaloid (epithelial) cells and a cribriform pattern (H&E, 20x HPF). (d) The proliferative index revealed an increased number of nuclei staining positively with Ki67 (clon Mib-1, immunohistochemistry, 40x HPF).
CRIPA2021-6674372.001.jpg
PMC8075656_03_CRIPA2021-6674372.001.jpg
fig1
Histology showed lobulated solid nests and microcystic areas (Figure 1(c)). The proliferation fraction index (Ki67) ranged from 20% to 30% in different areas (Figure 1(d)).
Two synchronous neonatal tumors. (a) Photographs showing the gross appearance of a multinodular mass corresponding to sialoblastoma (11 x 9 x 8.5 cm). (b) Sialoblastoma showing a solid lobular pattern with regular epithelial cells without either mitotic figures or pleomorphism (H&E, 40x HPF). (c) Light microscopy shows fetal and embryonal hepatocytes with a clear and acidophilic cytoplasm (H&E, 20x HPF). (d) Fetal epithelial hepatoblastoma area showing a characteristic pattern (H&E, 40x HPF).
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fig2
Histology showed epithelial hepatoblastoma of the fetal and embryonal subtype (Figures 2(c) and 2(d)). Macroscopy showed a specimen measuring 11 x 9 x 8.5 cm and another specimen of 3 x 3 x 2.5 cm including the parotid gland of 1.8 cm (Figure 2(a)). No infiltration of the capsule was observed, and the surgical margin was tumor-free (Figure 2(b)).
PMC8075656_04
Two synchronous neonatal tumors. Postsurgical photos of the patient: (a) surgical scar; (b, c) mild hemifacial paresis.
CRIPA2021-6674372.003.jpg
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fig3
After 2 years of follow-up, the general status of the boy was good with only mild hemifacial paresis (Figures 3(a)-3(c)).