PMC7532480_01
Transverse thin-section serial CT scans from a 53-year-old male with suspected COVID-19 pneumonia. Serial CT scans showed pericardial effusion, multiple enlarged lymph nodes in the mediastinum, scattered, multiple, similar round thin wall/no wall transparent areas (A2, B2, C3), smooth or nodular interlobular septal thickening (A1, B1), and multiple nodules in the dorsal segment of the lower lobe of both lungs with spotted calcifications and adjacent pleural thickening (A2, A3). Chest CT images performed at the 10th day after symptom onset showed patchy areas of consolidation co-existed with ground-glass opacities (A3), or linear scarring with discrete consolidation (A2), air bronchograms (A1), and irregular intralobular or interlobular septal thickening (A1-3, A3). Follow-up CT at the 13rd day demonstrated partial improvement (B1) but primarily increment in the extent and density (B2, B3), continued segmental consolidations and atelectasis in the lower lobe of both lungs (B3).
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F2
Results of serial CT scans showed pericardial effusion, multiple enlarged lymph nodes in the mediastinum, scattered, multiple, similar round thin wall/no wall transparent areas (Figure 2. A2, B2, C3), smooth or nodular interlobular septal thickening (Figure 2. A1, B1), and multiple nodules in the dorsal segment of the lower lobe of both lungs with spotted calcifications and adjacent pleural thickening (Figure 2. Moreover, compared with the previous CT scan 12.6 months before, chest CT images performed at the 10th day after symptom onset showed the obviously progressive lung lesions including patchy areas of consolidation co-existed with ground-glass opacities (Figure 2. A3), or linear scarring with discrete consolidation (Figure 2. A2), air bronchograms (Figure 2. A1), and irregular intralobular or interlobular septal thickening (Figure 2. After 3 days of anti-infective therapy with tazocin, moxifloxacin, and arbidol, combined with aggressive supportive care, follow-up CT demonstrated partial improvement (Figure 2. B1) but primarily increment in the extent and density of lung lesions (Figure 2. B3), and continued segmental consolidations and atelectasis were observed in the lower lobe of both lungs (Figure 2. B3).
PMC7532480_02
Transverse thin-section serial CT scans from a 55-year-old female with suspected COVID-19 pneumonia. Chest CT images performed on the 6th day after symptom onset indicated an enlarged mass with calcification in the left upper lobe and lung hilum and multiple mediastinal lymph node metastases (A1, B1, C1), bilateral diffused ground-glass opacities with partial consolidation (B2). Follow-up CT on the 15th day demonstrated continuous development in the scope and extent of lung lesions (C1, C2).
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Magnified irregular nodules scattered in both lungs, and metastatic tumors of the left pleura, the left pleural effusion and pericardial effusion increased in the extent and quantity (Figure 3. There were bilateral diffused ground-glass opacities with partial consolidation (Figure 3. B2), and a reticular pattern associated with bronchiectasis and intralobular or interlobular septal thickening (Figure 3. CT demonstrated continuous development in the scope and extent of lung lesions (Figure 3. C1, C2).
PMC7532480_03
Transverse unenhanced thin-section serial CT scans from a 64-year-old female with suspected COVID-19 pneumonia. Chest CT images on the second day after symptom onset found minimal ground-glass opacities with partially rounded consolidation in the apexes of both lungs (A1), and multiple ill-defined patchy ground-glass opacities in the middle lobe of right lung (A2). Follow-up CT on the fifth day demonstrated no obvious change of lung lesions (B1, B2).
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Chest CT images were obtained on the second day after symptom onset and indicated that there were minimal ground-glass opacities with partially rounded consolidation (Figure 4. Multiple ill-defined patchy ground-glass opacities (Figure 4. Follow-up CT demonstrated no obvious changes of lung lesions (Figure 4.
PMC7532480_04
Transverse unenhanced thin-section serial CT scans from a 39-year-old male with COVID-19 pneumonia. Chest CT images on the 10th day after symptom onset demonstrated multiple ground-glass opacities of the lower lobes of both lungs peripherally (A2), and a few linear opacities in upper lobe lower lingual segment of the left lung (A3). Follow-up CT at the 18th day demonstrated significant improvement in the extent and density of the ground-glass opacities (B2), and appearance of new focal ground-glass opacities of the upper lobe of right lung (B1).
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F5
CD4+ and CD8+ T cell counts. Chest CT images were obtained on the 10th day after symptom onset and showed that there were multiple ground-glass opacities of the lower lobes of both lungs peripherally and subpleurally (Figure 5. A few linear opacities were presented in upper lobe lower lingual segment of the left lung (Figure 5. After 8 days of anti-viral therapy with resochin and supportive treatment, follow-up CT scans demonstrated a significant improvement in the extent and density of the ground-glass opacities (Figure 5. B2), but found a new focal ground-glass opacity (GGO) in the upper lobe of right lung (Figure 5.