PMC3886224_01
Histopathological pictures of the last high-grade osteosarcoma of the right distal femur in 2005 (a) before and (b) after chemotherapeutic application.
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The following biopsy at the University Hospital Graz revealed again a high-grade osteosarcoma (Figure 1(a)), and once more, screening showed no evidence of any extraskeletal tumour suspect lesions. A regression grade of 5 was achieved (Figure 1(b)), identical to the first osteosarcoma response.
Overview about localisation, timely occurrence, and operative intervention of the three metachronous osteosarcomas as in our 48-year-old male patient 30 years after first osteosarcoma diagnosis.
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After the revision procedure, no further complications occurred and the patient is now able to walk without braces or canes representing a good functional outcome (Figure 2).