PMC5465240_01
Fetal magnetic resonance imagings (MRIs). (A) Week 26 of gestation, axial T2 haste weighted sequence. Red arrows indicate intraventricular cysts in the posterior horns of slightly dilated lateral ventricles. (B) Week 36 of gestation, coronar T2 haste weighted sequence. Red arrows show intraventricular cysts, yellow arrow marks diffuse white matter lesions with increased T2 intensity.
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F1
Prenatal magnetic resonance imaging (MRI) confirmed bilateral intraventricular cysts and mild dilation of both posterior horns of the lateral ventricles (Figure 1A). At 36 weeks of gestation, a second MRI revealed additional diffuse white matter hyperintensities (Figure 1B).
Postnatal magnetic resonance imagings (MRIs) at day of life 5. Axial (A) and coronar (B) T2-weighted sequences. Red arrows show septa of intraventricular cysts in the area of the former matrix germinativa (loco classico). Slight dilatation of both lateral ventricles. Yellow arrows mark white matter hyperintensities bi-frontally and occipitally. No signs of calcification or polymicrogyria.
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F2
PCR in infant blood and urine samples (9,710 and 7.09 log GEq/ml, respectively). After informed consent to administer antiviral therapy was obtained from the parents, intravenous (i.v.) ganciclovir (7.5 mg/kg/dose 12 h) therapy was initiated. Postnatal MRI on day 5 of life revealed bilateral subependymal cysts, mild dilatation of both lateral ventricles and white matter hyperintensities (which had already been detected during fetal imaging), but neither calcifications nor polymicrogyria were observed (Figures 2A,B).
Magnetic resonance imaging (MRI) at age of 4 years. (A) Axial T2-weighted sequence. Residual white matter hyperintensities (due to demyelination and gliosis) with periventricular location on both sides (yellow arrows) and persistent intraventricular septa, mainly in the occipital region (red arrow). (B) Coronar T2-weighted sequence. Residual periventricular hyperintense white matter lesions (yellow arrows).
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F3
A cranial MRI showed regressive cerebral abnormalities (periventricular white matter lesions on both sides due to demyelination and gliosis, and intraventricular occipital adhesions, Figures 3A,B) without any signs of intracranial bleeding, infection or tumor.