PMC3884169_01
The right side of the patient's face before (a) and after (b) imiquimod 5% cream therapy (once a day, 3 times weekly for 16 weeks). Note the disappearance of the keratotic rim, the flattening of the lesions and the improvement in the color and thickness of the scars. Residual hyperpigmentation and hypopigmentation remained unchanged.
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F1
The lesions were asymptomatic and symmetrically distributed on both sides of the face (figs. 1, 2).
The patient before (a) and after (b) imiquimod 5% cream therapy (once a day, 3 times weekly for 16 weeks). Notice the flattening of the lesions and the improvement of skin texture.
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PMC3884169_01_cde-0005-0283-g02.jpg
F2
The lesions were asymptomatic and symmetrically distributed on both sides of the face (figs. 1, 2).
A histopathology section. x100. Black arrows point to invaginations in the epidermis of both specimens. Note the outward projection of a parakeratotic column called the cornoid lamella. This is a classic, characteristic picture of porokeratosis.
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F3
The diagnosis was confirmed as DSAP, with a classic and very illustrative pathological picture (figs. 3-6).
A histopathology section. x 200. A closer view of the pathognomonic features of porokeratosis.
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F4
The diagnosis was confirmed as DSAP, with a classic and very illustrative pathological picture (figs. 3-6).
A histopathology section. x400. A section showing abnormal vacuolated keratinocyte clones that develop in between normal cells and interrupt the granular layer, with no granules in the abnormal cells. A column of parakeratotic cells forms, called the cornoid lamella.
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PMC3884169_01_cde-0005-0283-g05.jpg
F5
The diagnosis was confirmed as DSAP, with a classic and very illustrative pathological picture (figs. 3-6).
A histopathology section. x400. Another lesion with similar features to figure 5.
cde-0005-0283-g06.jpg
PMC3884169_01_cde-0005-0283-g06.jpg
F6
The diagnosis was confirmed as DSAP, with a classic and very illustrative pathological picture (figs. 3-6).