PMC5436031_01
Laboratory data fluctuation. A line graph demonstrates the fluctuations of AST/ALT levels. The horizontal axis shows the number of weeks after nivolumab induction. At week 34, these enzymes were suddenly elevated. After corticosteroid initiation, the levels of these enzymes rapidly improved.
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After approximately 34 weeks of nivolumab administration (Fig. 1), laboratory tests revealed a sudden elevation of liver enzymes (AST/ALT) to 1,225/824 U/L (grade 4).
CT of the abdomen. a CT scan before hepatitis: a large metastatic lesion is present in the left lobe (yellow arrowhead). b Three months later, during hepatitis, the metastatic lesion became larger (yellow arrowheads). However, the lesion was localized, not diffuse.
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Computed tomography detected the exacerbation of liver metastasis, identifying a lesion that was slightly larger than the nondiffuse, localized lesion that had been observed 3 months earlier (Fig. 2).