PMC8520425_01
clinical presentation
PAMJ-39-254-g001.jpg
PMC8520425_01_PAMJ-39-254-g001.jpg
F1
Patient information: a 23-year-old young man, healthy and not known to have any prior medical illnesses was referred to our clinic complaining of a painless neck mass that he noticed slowly growing for the past 4 years (Figure 1).
thyroglossal cyst
PAMJ-39-254-g002.jpg
PMC8520425_01_PAMJ-39-254-g002.jpg
F2
Therapeutic intervention: Sistrunk operation was first performed with en bloc resection of the mass with surrounding involved muscle tissue and mid-section of the hyoid bone (Figure 2).
positive immunostain
PAMJ-39-254-g003.jpg
PMC8520425_01_PAMJ-39-254-g003.jpg
F3
Immunohistochemical staining (IHC) stains used: thyroglobulin focally positive, B-cell lymphoma-2 (BCL2): positive, creatine kinase (CK): positive, protein 53 gene (P53): focally positive, focally positive, cytokeratin 19 (CK19) and epithelial membrane antigen (EMA) were positive but synaptophysin, chromogranin, calcitonin, high molecular weight cytokeratin (HMWCK), thyroid transcription factor 1 (TTF-1), neural\melanocytic marker (S100), leukocyte common antigen (LCA), Desmin, paired box gene-8 (PAX-8), creatin kinase-7 (CK7) were all negative (Figure 3, Figure 4).
thyroglobulin immunostain
PAMJ-39-254-g004.jpg
PMC8520425_01_PAMJ-39-254-g004.jpg
F4
Immunohistochemical staining (IHC) stains used: thyroglobulin focally positive, B-cell lymphoma-2 (BCL2): positive, creatine kinase (CK): positive, protein 53 gene (P53): focally positive, focally positive, cytokeratin 19 (CK19) and epithelial membrane antigen (EMA) were positive but synaptophysin, chromogranin, calcitonin, high molecular weight cytokeratin (HMWCK), thyroid transcription factor 1 (TTF-1), neural\melanocytic marker (S100), leukocyte common antigen (LCA), Desmin, paired box gene-8 (PAX-8), creatin kinase-7 (CK7) were all negative (Figure 3, Figure 4).
bilateral thyroid specimen
PAMJ-39-254-g005.jpg
PMC8520425_01_PAMJ-39-254-g005.jpg
F5
Total thyroidectomy specimen showed benign thyroid tissue with no tumor identified (Figure 5).