PMC8777186_01
Representative images from patients in this case series. (A) CT imaging from a 58-year-old male former smoker with a diagnosis of stage IVB NSCLC with an adenosquamous histology harboring a CD74-ROS1 fusion upon progression on entrectinib and prior to use of carboplatin, pemetrexed and pembrolizumab. (B) CT imaging of best-treatment response with significant reduction in the size of the left supraclavicular lymph node. (C) PET/CT imaging from a 40-year-old male never smoker with stage IVB NSCLC with an adenosquamous histology harboring an EML4-ALK fusion prior to treatment with single agent pemetrexed. (D) PET/CT imaging demonstrating significant improvement within known right paratracheal nodes.
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His first on-treatment scan demonstrated a partial response ( Figure 1 ) .
PMC8777186_02