PMC9615437_01
(A) Hepatoblastoma with fetal and embryonal pattern (HE x40). (B) The fetal component is formed of small and uniform cells with clear or eosinophilic cytoplasm (HE x400). (C) The embryonal component is composed of cells resembling blastemal cells with dark and scant cytoplasm and large nuclei (HE x400). Tumor cells show : (D) Cytoplasmic and membranous b-catenin staining (x400). (E) Strong coarse granular glypican 3 staining (HE x200) and (F) GS diffuse strong cytoplasmic staining( HE x200).
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Tumor cells were negative for chromogranine and synaptophysin (Figure 1).
PMC9615437_02
(A) Mixed hepatoblastoma composed of mesenchymal and epithelial cells.(HE x100). (B) The epithelial component is characterized by cells grouped in nests, islands, and broad trabeculae (HE x200). (C) Some areas showed glandular and rosette formation (HE x400) (D) Tumor cells are positive for synaptophysin (x40) (E), and chromogranin A (x400). (F), beta-catenin staining exhibit a mixed nuclear and cytoplasmic pattern of the tumor cells (x200).
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Scattered cells showed positive staining of EMA.beta-catenin staining exhibited a mixed nuclear and cytoplasmic pattern of the tumor cells (Figure 2).These pathology results were consistent with the diagnosis of a mixed hepatoblastoma.