PMC9927007_01
(A) Contrast-enhanced magnetic resonance angiogram showing areas of signal abnormality in both the right temporal lobe and frontal lobe with areas of contrast enhancement in March 2022 (B) Contrast-enhanced magnetic resonance angiogram showing that the lesion disappeared without obvious enhancement 3 months after the CAR T cell infusion, indicating that the patient achieved complete remission. The red arrow represents the lesions.
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Brain enhanced magnetic resonance imaging showed lymphoma in the right temporal lobe and frontal lobe, accompanied by peripheral cerebral edema and right subfalcine herniation ( Figure 1 ).
The patient underwent peripheral blood mononuclear cell and plasma collection on d-10 and received conditioning regimen before HSC infusion on do. Two separate CAR T-cell products (CD22 and CD19 CAR T-cells) were infused within the range of 3-4 days (d+3 to d+4) after HSC infusion.
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T-cell products (2x106/Kg CD22 CAR T cells and 2x106/Kg CD19 CAR T cells) were infused in the patient for 2 consecutive days (d+3 to d+4), respectively ( Figure 2 ). The two CAR T cells were provided by Shanghai Yake Co.