PMC6584846_01
Pathologic features of blood, bone marrow, and lymph node. (A) The blood smear showed a marked increase of reactive circulating plasma cells. (B) Bone marrow biopsy showed diffuse infiltration of atypical lymphocytes admixed with numerous reactive plasma cells. (C) The left inguinal lymph node revealed diffuse infiltration of small to medium-sized atypical lymphocytes and scattered large immunoblasts, with exuberant vascular proliferation and numerous reactive plasma cells. (D-F). The atypical lymphocytes expressed CD3 (D). Scattered immunoblasts expressed CD20 (E) and EBER by in situ hybridization (F) (Magnification: A. x100, B-F. x40).
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F1
Representative images are shown in Figure 1.