PMC9894633_01
Patient presenting with severe Darier disease (baseline)
cureus-0015-00000033321-i01.jpg
PMC9894633_01_cureus-0015-00000033321-i01.jpg
FIG1
Histopathology of an abdominal papule, revealing acantholytic dyskeratosis. A suprabasal cleft can be observed (yellow arrow). A rounded cell, with basophilic nuclei, perinuclear halo, and eosinophilic cytoplasm (white arrow), corresponds to the traditionally described "corps ronds." The elongated, small, acantholytic cells located in the upper layers of the stratum corneum (black arrows) correspond to the "grains."
cureus-0015-00000033321-i02.jpg
PMC9894633_01_cureus-0015-00000033321-i02.jpg
FIG2
A punch biopsy of an abdominal papule was then performed (Figure 2), revealing acantholytic dyskeratosis with a suprabasal cleft.
Patient after three months of combination therapy with LDN and oral isotretinoin. LDN: low-dose-naltrexone
cureus-0015-00000033321-i03.jpg
PMC9894633_01_cureus-0015-00000033321-i03.jpg
FIG3