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Mediolateral oblique view of the right breast demonstrates (A) in April 2012, the presence of a calcified fibroadenoma (arrow) and (B) in May 2013, a dense opacity, slightly heterogeneous with numerous calcifications in the part upper outer of the breast (arrow).
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At that time, we described a calcified fibroadenoma that measured 1 cm (Fig. 1A). On the mammography, we identified a dense opacity area with numerous calcifications, estimated to be 25 mm wide and 29 mm high (Fig. 1B).
Technetium 99-methylene diphosphonate bone scintigraphy showing an intense uptake in the right breast corresponding to the primary osteosarcoma (arrows).
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A technetium 99-methylene diphosphonate (Tc-99 m) bone scintigraphy did demonstrate an intense localized uptake in the right breast (Fig. 2), no metastatic lesions were observed.
Microscopic image from the piece of tumorectomy showed malignant mesenchymal tumor-like osteogenic sarcoma with osteoclastic and osteoblastic activity with osetoid formation, (hematoxylin-eosin, original magnification x200). Multinucleated osteoclastic giant cells (arrows).
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Histology of the tumorectomy showed a prominent component of high-grade spindle cell sarcoma with osseous differentiation in which there may be patches of osteoid formation and multinucleated osteoclastic giant cells associated with hemorrhagic cysts with telangiectasic appearance (Fig. 3).
Mediolateral oblique view of the left breast (A) in April 2012, no abnormality is detected and (B) in August 2014, a dense nodular opacity, with slightly irregular outline in the infero-medial region, is observed (arrow).
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A mammography showed a nodular dense opacity measuring 25 mm wide and 27 mm high (Fig. 4).