PMC6279989_01
A: Ultrasonography scan of the upper abdomen shows a round and well-defined mass in the stomach. Fig. 1B: Endoscopic ultrasound reveals a 2.5 x 1.5 cm hypoechoic mass that appears to arise from the muscolaris propria of the lesser curvature.
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54-year old female with a history of hypertension and gallbladder polyp was admitted to our department for the evaluation of a gastric lesion that was detected incidentally during ultrasonography scan of the upper abdomen (Fig. 1A). Esophagogastroduodenoscopy (EGD) and endoscopic ultrasound (EUS) (Fig. 1B) confirmed the presence of a 2.5 x 1.5 cm hypoechoic and submucosal lesion situated along the lesser curvature of the stomach.
Spindle cells arranges in fascicles (HE 4x) and in the frame the mass partially surrounded by lymphoid aggregates (HE 10x).
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Histopathology findings of frozen section was characterized by interlacing bundles of spindle cells of varying cellularity and peripheral lymphoid cuffs (Fig. 2).
Tumor cells are positive for S-100 protein in both cases (IHC case 1, 4x Fig. 3A), (IHC case 2, 4x Fig. 3C) and negative for CD-117 protein (ICH case 1, 40x Fig. 3B) and CD-34 (IHC case 2, 10x Fig. 3D).
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Neoplastic cells were strongly positive for S-100 protein (Fig. 3A), but they were negative for CD-34, CD-117 (Fig. 3B), smooth-muscle actin and desmin.
PMC6279989_02
Contrast enhanced CT showing a round, well-defined and homogeneous gastric mass (Fig. 4A) and endoscopic detection (Fig. 4B) in submucosal of the greater curvature of the stomach. In the frame, macroscopic view of the resected mass shows a large exophytic mass along the less curvature of the stomach.
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CT scanning revealed a homogeneous round mass measuring 5 cm, arising from the posterior wall of the stomach (Fig. 4A). Upper gastrointestinal endoscopic examination revealed a protruding submucosal mass between antrum and body of the stomach along greater curvature (Fig. 4B). Tumor cells showed strong immunoreactivity for S-100 protein (Fig. 4C) but were negative for CD-117 and CD-34 (Fig. 4D).