PMC6875255_01
Giant squamous cell papilloma involving the left lower eyelid (a) and (b).
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fig1
Parts of the lesion exhibited necrosis and keratinization (Figure 1).
Clinical appearance of the left lower eyelid 1 week (a) and (b) and 2 months (c) and (d) after tumor removal and surgical reconstruction of the excised area.
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fig2
The medial canthal area with the lacrimal punctum could be spared, allowing direct suturing of the septal cartilage (Figure 2).
Histopathological features. (a) Hyperkeratotic epidermis and endophytic epithelial growth into the dermis with squamous pearl (arrow). There is only mild cytological atypia with intact basement membrane and no increased mitotic activity indicative of the benign nature of the lesion (inset). (b) Diffuse p16 immunopositivity both in the nucleus and in the cytoplasm (see inset) confirms HPV infection. Note the immunonegativity in the adjacent epidermis. (a: Haematoxylin & Eosin, original magnification: x20; inset: x300; b: Immunohistochemistry with DAB chromogen, using monoclonal antibody (clone MX007, Master Diagnostica; x20; inset: x300).
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fig3
The histopathological examination established the diagnosis of HPV induced endophytic SCP and confirmed the complete excision of the lesion (Figure 3).