PMC3087490_01
Mass in the axillary tail of the left breast (mammographic image).
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fig1
Mammography revealed a smooth bordered opacity with a 1 cm diameter in the axillary tail of the left breast (Figure 1).
Nests of polygonal cells with eosinophilic cytoplasm divided by fibrous septa (H&E, x40).
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fig2
The histological examination revealed polygonal cells with eosinophilic granular cytoplasm, and fibrous septae between the clusters (Figure 2), cells with vesicular nuclei with prominent nucleoles and eosinophilic granular cytoplasms and eosinophilic intracytoplasmic particles surrounded by a clear halo (Figure 3).
Eosinophilic granular cells with vesicular nuclei, prominent nucleoli, and in addition intracytoplasmic eosinophilic particles surrounded by a clear zone (H&E, x100).
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fig3
The histological examination revealed polygonal cells with eosinophilic granular cytoplasm, and fibrous septae between the clusters (Figure 2), cells with vesicular nuclei with prominent nucleoles and eosinophilic granular cytoplasms and eosinophilic intracytoplasmic particles surrounded by a clear halo (Figure 3).
Tumor cells showing diffuse strong immunostaining for S-100 protein (x40).
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fig4
In immunohistochemical examination, S-100 protein (Figure 4), CEA, and vimentin were (+), and cytokeratin was (-) (Figure 5), and these findings led us to the diagnosis of granular cell tumor.
The lack of GCDFP-15 immunostaining in tumor cells (x40).
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fig5
In immunohistochemical examination, S-100 protein (Figure 4), CEA, and vimentin were (+), and cytokeratin was (-) (Figure 5), and these findings led us to the diagnosis of granular cell tumor.