PMC5026692_01
Chest CT. A. right middle lobe consolidation (arrow) at the time of presentation. B. The infiltrate has resolved 1 month later after treatment with prednisone and cessation of pembrolizumab.
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Compared with images from 5 weeks earlier, a contrast-enhanced chest CT showed new focal airspace opacities in the right middle lobe (Fig. 1A). A follow-up chest CT showed complete resolution of the right middle lobe infiltrate (Fig. 1B).
Transbronchial biopsy findings. A. An inflammatory infiltrate composed of lymphocytes and eosinophils is seen within the bronchial mucosa (arrow and inset, bottom left). There is evidence of damage to the bronchial epithelium in the form of denudation of surface ciliated columnar cells and reactive changes in the basal epithelium (arrowhead). B-E. The lymphocytes are mainly T-cells, CD4>CD8 (B. CD3. C. CD20. D. CD4. E. CD8).
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The inflammatory infiltrate in the bronchial mucosa was composed mainly of lymphocytes and eosinophils (Fig. 2A). As expected in a reactive inflammatory infiltrate, the lymphocytes were mainly CD3-positive T cells (CD4>CD8) (Fig. 2B-E).