PMC3931533_01
Radiation-induced angiosarcoma (right breast) occurring on irradiated skin in December 2007.
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figure1
It was noted that the skin 'spot' was now 7 x 5 cm in size and was associated with indurations, thickness, and itching in the lower outer quadrant of the right breast (Figure 1).
This high power view (x40 magnification) shows neoplastic vascular channels. These irregular channels interconnect and are lined by a single layer of highly atypical endothelial.
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figure2
The histopathological examination showed that an inflammatory area of 5 x 4 cm with angiosarcoma grade I, anti-CD 31, and CD 34, was positive; the lymph nodes were free of metastasis (Figure 2).