PMC5760078_01
Images of hepatic transjugular biopsy: in the middle, the red arrows showed the expansion of hepatic sinusoid spaces, on the right the figure showed a centrilobular vein.
mjhid-10-1-e2018001f1.jpg
PMC5760078_01_mjhid-10-1-e2018001f1.jpg
f1-mjhid-10-1-e2018001
Histology studies showed the expansion of the hepatic sinusoid spaces, with gaps in the sinusoidal barrier which were highly suggestive of hepatic VOD in the light of the involvement of zone 3, zone 2 and partially zone 1 of the hepatic acinus (Figure 1).
Diagnostic interventions with liver function profile from clinical onset of VOD until resolution, and treatment of VOD in case 1.
mjhid-10-1-e2018001f2.jpg
PMC5760078_01_mjhid-10-1-e2018001f2.jpg
f2-mjhid-10-1-e2018001
Two-three days after the beginning of defibrotide, the patient showed a marked clinical improvement with gradual improvement and normalization of liver and renal function tests (Figure 2).
PMC5760078_02