PMC10066873_01
Imaging features of patients. (a) The density of the liver parenchyma increases diffusively in the CT portal vein stage, with a CT value of approximately 96 HU. Liver tissue sampling points (arrows). (b) In the magnetic resonance imaging T2 stage, the signals of the liver and spleen were low.
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Further, enhanced computed tomography (CT) showed a large liver volume, a moderate proportion of liver lobes, small wavy change in the left edge of the liver lobe, diffuse increase in the density of liver parenchyma, and a CT value of approximately 96 HU (Figure 1a). In addition, magnetic resonance imaging showed low signals in both the liver and spleen (Figure 1b), indicating hemochromatosis.
Pathological features of the liver tissue. (a) Hepatocytes filled with iron particles (arrow). Hematoxylin-eosin staining (10 x 20). (b) The portal area covered with blue iron particles (arrows). Prussian iron staining (10 x 20). (c) Immunohistochemical staining for cytokeratin 7 shows hyperplasia of the bile duct and deposition of iron particles in the bile duct (arrow; 10 x 20). (d) Deperiodic acid-Schiff staining shows iron particles in the macrophages (arrow; 10 x 20).
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The pathological characteristics of the liver biopsy are shown in Figure 2.