PMC5814571_01
Neoplastic infiltrating glands consistent with adenocarcinoma.
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F1
Biopsies of the rectosigmoid ulcer were compatible with a moderately differentiated adenocarcinoma, while those of the aphtous ulcers were consistent with severe ulcerative colitis (Figure 1).
(A) Hematoxylin and eosin stain showing small, round lymphocytic infiltrate next to and admixed with a moderately differentiated adenocarcinoma. (B) Evidence of colliding lymphoma (upper) and adenocarcinoma (lower).
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F2
Adjacent to the carcinoma, a diffuse mononuclear large cell infiltrate was positive for bcl-2 and CD20 immunoperoxiadases, which is consistent with a diffuse large B-cell lymphoma (Figures 2 and 3).
Immunostaining showing a section of the neoplastic lymphoid cells, which show membranous staining with CD20, consistent with a B-cell lymphoma.
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F3
Adjacent to the carcinoma, a diffuse mononuclear large cell infiltrate was positive for bcl-2 and CD20 immunoperoxiadases, which is consistent with a diffuse large B-cell lymphoma (Figures 2 and 3).