PMC5470565_01
- Photomicrography of the biopsied specimen (mammary tissue). A - Well-differentiated carcinoma infiltrating the mammary parenchyma (HE, 100X). B - In detail: note the cellular pattern arrangement and the scarcity of mitotic figures (HE, 400X).
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The histological examination revealed a well-differentiated carcinoma infiltrating the mammary parenchyma, with peripheral microcalcifications, but an absence of the in situ component (Figure 1).
- Photomicrography of the biopsied specimen (mammary tissue). Immunohistochemical preliminary workup. A - Negative for the nuclear estrogenic receptor (200X). B - Negative for the nuclear progesterone receptor (400X). C - Negative for cEBR (HER2) (400X). D - Proliferative index below 5% (Ki67) (400X).
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- Photomicrography of the biopsied specimen (mammary tissue). Complementary immunohistochemical workup. A - Chromogranin positive. B - Calcitonin positive.
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In the light of these histological findings and additional clinical information, a new immunohistochemical panel was tested, which showed positive for chromogranin and calcitonin (Figure 3).