PMC8117341_01
Case 1 demonstrating (A) Increase in size of right thigh mass (B) CD3 positive (C) CD5 positive (D) CD 68 positive immunohistochemical staining.
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Immunohistochemistry revealed CD4+ infiltrating lymphocytes and CD68+ histiocytes ( Figures 2C, D  and  Table 1 ).
PMC8117341_02
Case 1 demonstrating (A) Increase in size of right thigh mass (B) CD3 positive (C) CD5 positive (D) CD 68 positive immunohistochemical staining.
fonc-11-679177-g001.jpg
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Immunohistochemistry revealed CD4+ infiltrating lymphocytes and CD68+ histiocytes ( Figures 2C, D  and  Table 1 ).
Case 2 demonstrating descending colon mass before (A) and after (B) nivolumab treatment; (C) CD4 positive (D) CD 68 positive immunohistochemical staining.
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Follow up CT after 6 doses of nivolumab showed interval worsening of lung metastases, left hilar adenopathy, new liver and right adrenal metastases, and marked enlargement of the descending colon mass from 2.1 x 3.1 cm to 8.8 x 10.6 cm ( Figures 2A, B ). Immunohistochemistry revealed CD4+ infiltrating lymphocytes and CD68+ histiocytes ( Figures 2C, D  and  Table 1 ).
PMC8117341_03
Case 3 demonstrating stomach mass before (A) and after (B) nivolumab treatment (C) extensive necrosis with no viable tumor (H&E, x100).
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There was also marked interval enlargement of a multilobular mass tethered to the gastric wall, from 1.3 x 1.5 cm to 5.0 x 7.0 cm, concerning for metastasis versus a second primary cancer ( Figures 3A, B ). However, biopsies revealed only extensive necrosis and inflammatory changes with focal granulation tissue response, and no evidence of viable malignancy ( Figure 3C ).