PMC6472884_01
Pedigrees of MSMD families.. The patients with MSMD indicated with P1, P2, P3. All the patients of MSMD carry the compound heterozygous mutations in IL12RB1 gene.
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PMC6472884_01_pone.0215648.g001.jpg
pone.0215648.g001
Pedigree of the three families were shown in Fig 1.