PMC6005277_01
PMC6005277_02
Inflammation in and about the eye in a Doberman treated with G6PD inhibition for a cytologically verified soft tissue sarcoma in her right ischium. Inflammation such as this is a feature of the human autosomal recessive disease mevalonate kinase deficiency, caused by NALP3 inflammasome-mediated IL1beta secretion.
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DHEA and 0.1 mg/kg/day ubiquinone. During treatment, an acute inflammatory reaction involving the eyes was noted (Figure 1).
Interdigital inflammatory skin lesion closely resembling those observed in MKD patients. This patient had numerous such lesions on her extremities, trunk, and foot pads.
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This was followed by multiple inflammatory cutaneous lesions on the legs, foot pads, and trunk (Figure 2).
Radiographs of a dog with soft tissue sarcoma before and after treatment with high dose DHEA. Note the right ischial soft tissue sarcoma (a) which completely resolved as a result of treatment (b).
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Of note, posttreatment radiographs showed complete tumor regression (Figure 3).