PMC5588789_01
(a) and (b) A 3.8 cm well-circumscribed submucosal mass lesion involves the anterior lip of cervix and has yellow-tan and gelatinous external and cut surfaces. No hemorrhage or necrosis is identified.
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The cut surfaces were homogeneous pink to tan and soft to firm, without any necrosis, induration, or infiltration (Figure 1).
(a) Neoplasm composed of relatively hypocellular ovoid, stellate to spindle-shaped cells in a patternless distribution in an edematous to myxoid, variably collagenized, and vascularized stroma. The vessels range from thick walled to capillaries some of which irregularly stag-horn shaped (H&E 50x). (b) and (c) Individual neoplastic cells are mostly stellate with bland to mildly pleomorphic hyperchromatic ovoid to spindle nuclei. No epithelioid, multinucleated, or perivascular cuffing by tumor cells is seen. No anaplasia or mitosis was identified (H&E 200x).
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The vessels ranged from thick-walled vessels to capillaries, some of which were irregularly stag-horn shaped (Figure 2(a)). There was no mitotic activity or necrosis identified (Figure 2(b) and (c)).
Neoplastic cells exhibited diffuse immunopositivity for desmin in spindle and stellate lesional cells: (a) desmin 50x and (b and c) desmin 200x.
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An immunohistochemical analysis showed diffuse positivity for desmin in spindle and stellate lesional cells (Figure 3).
Staining with CD34 was positive in a large subset of spindle and stellate cells (CD34 200x).
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Staining with CD34 was positive in a large subset of spindle and stellate cells (Figure 4).
Smooth muscle actin staining was positive in a small subset of cells (SMA 200x).
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Alpha-SMA staining was positive in a small subset of cells (internal control staining of vessels and smooth muscle cells noted; Figure 5).
Two age-matched and site-matched (anterior) non-neoplastic cervix sections from unrelated cases used as controls: (a and b) H&E 200x, (c and d) desmin 50x, and (e and f) desmin 200x.
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Two age-matched and site-matched (anterior) non-neoplastic cervix sections from unrelated cases were used as controls (Figure 6).