PMC5949169_01
Gross and histologic examination of organs involved with lymphoma. (a) A pedunculated and a subendothelial lymphoma lesion observed in the right atrium. (b) Left upper lung with multiple tan-white tumor lesions. (c) The aorta, lymphoma cells in the small vessel (hematoxylin and eosin (H&E), x100). (d) Left atrium vessel with neoplastic lymphoid infiltrate (H&E, x200).
CRIRH2018-5364985.001.jpg
PMC5949169_01_CRIRH2018-5364985.001.jpg
fig1
On autopsy, subendothelial and pedunculated lesions were seen in the right atrium of the heart (Figure 1(a)). Multiple tan-to-pale white tumor lesions were seen in the left lung (Figure 1(b)), right lung, right and left kidneys, retroperitoneal lymph nodes, right liver lobe, stomach, right and left adrenal glands, small intestine, bladder, thyroid, and brain. Histologic sections of the lesions showed disseminated neoplastic lymphoid cells in the lumen of small and intermediate vessels in the organs including the aorta (Figure 1(c)), right atrium (Figure 1(d)), brain (Figure 2(a)), bladder (Figure 2(b)), thyroid (Figure 2(c)), right and left kidneys, retroperitoneal lymph nodes, right liver lobe, stomach, right and left lungs, right and left adrenal glands, and small intestine.
Histological and immunohistochemical staining of intravascular lymphoma cells. Small vessel lumen involved by lymphoma cells in the (a) brain (hematoxylin and eosin (H&E), x100), (b) bladder (H&E, x400), and (c) thyroid (H&E, x40). (d) The neoplastic lymphoid cells in the coronary artery are positive for CD20 (H&E, x200).
CRIRH2018-5364985.002.jpg
PMC5949169_01_CRIRH2018-5364985.002.jpg
fig2
Histologic sections of the lesions showed disseminated neoplastic lymphoid cells in the lumen of small and intermediate vessels in the organs including the aorta (Figure 1(c)), right atrium (Figure 1(d)), brain (Figure 2(a)), bladder (Figure 2(b)), thyroid (Figure 2(c)), right and left kidneys, retroperitoneal lymph nodes, right liver lobe, stomach, right and left lungs, right and left adrenal glands, and small intestine. The atypical lymphocytes were positive for CD20 (Figure 2(d)) on immunohistochemical staining and negative for CD3, CD5, CD10, CD56, MUM-1, and cytokeratin.