PMC8076566_01
(A, B) Clinical pictures at first visit: multiple slightly palpable black spots on penis and scrotum. (C) Dermoscopy of a corresponding lesion of the glans penis: homogeneous dark-brown and black spots largely lacking net-like structures. (D-G) Microscopic pictures of a biopsy taken from the penis. (D) H&E-staining showing atypical melanocytes with focal pagetoid infiltration of the epidermis and strong junctional melanocytic pigmentation with pigmentary incontinence. Intraepidermal melanocytes strongly express SOX10 (E), HMB45 (F), and S100 (G). (H) PET-CT scan with highly suspicious lymph nodes in the left hilus region (red rectangle). Scale bar in D = 100 microm.
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A 65-year old male patient was sent to our outpatient department with rapidly growing black macules on the penis ( Figures 1A, B ).