PMC8226359_01
Fundus photograph (arrow in A) and ultrasonography (B) of a large choroidal
tumor in the right eye of a 73-year-old man at the initial visit. The tumor
has regressed rapidly to become flat retinal degeneration (arrow in C) in
response to 1-month hormonal therapy with degarelix. No relapse (arrow in D)
in the right eye 3 years after the initial visit.
10.1177_23247096211026471-fig1.jpg
PMC8226359_01_10.1177_23247096211026471-fig1.jpg
fig1-23247096211026471
At the visit to an ophthalmologist, he was found to have a large nonpigmented dome-shaped choroidal mass in the superotemporal quadrant of the midperipheral fundus of the right eye, associated with serous subretinal fluid, which extended to the macular area and inferior to the choroidal mass (Figure 1A and B). One month after the initial visit, the choroidal tumor resolved rapidly and became flat degeneration in response to the initial dose of hormonal therapy (Figure 1C). Throughout the course, the right eye showed flat retinal regeneration corresponding to the area of the previous choroidal tumor (Figure 1D).
An intraocular mass (arrow in A) in the right eye with mildly low T2-weighted
signal in magnetic resonance image in a 73-year-old man at the initial
visit. Abnormal uptake in the right eye (arrow in B, standardized uptake
value SUVmax = 3.31), prostate (arrow in C, SUVmax =
4.75), vertebral bones (arrow in D, SUVmax = 8.01), and
mediastinal lymph node (arrow in E, SUVmax = 5.77) in whole-body
2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography
(FDG-PET) at the initial visit. Note multiple lung-field lesions (arrow in
F) in computed tomography scan combined with PET.
10.1177_23247096211026471-fig2.jpg
PMC8226359_01_10.1177_23247096211026471-fig2.jpg
fig2-23247096211026471
Abnormal uptake was found in the prostate (standardized uptake value [SUVmax] = 4.75; Figure 2C), vertebral bones (SUVmax = 8.01; Figure 2D), bilateral hilar and mediastinal lymph nodes (SUVmax = 5.77; Figure 2E), and bilateral lung fields, in addition to the right eye (SUVmax = 3.31; Figure 2B). The combined computed tomography (CT) scan showed multiple lung-field nodular lesions on both sides (Figure 2F), indicative of metastatic lesions in the lung. Head magnetic resonance imaging showed an intraocular mass with mildly high T1-weighted signal, mildly low T2-weighted signal, and high diffusion-weighted signal in the right eye (Figure 2A), but no intracranial abnormalities.
Needle biopsy specimen (A in low magnification and B in high magnification)
of the prostate 2 months after the initial visit. Note irregular arrangement
of fused glands. Gleason score, which was a presumed value since the patient
was under hormonal therapy, was designated 4 + 4 = 8, indicative of poorly
differentiated adenocarcinoma. Bar = 200 microm in A and 50 microm in B.
10.1177_23247096211026471-fig3.jpg
PMC8226359_01_10.1177_23247096211026471-fig3.jpg
fig3-23247096211026471
Two months after the initial visit, needle biopsy of the prostate showed poorly differentiated adenocarcinoma with Gleason score of 4 + 4 = 8 (Figure 3A and B), which was indeed a presumed value as he was under hormonal therapy.