PMC5904798_01
Abdominal CT scan at diagnosis.
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He was seen by his primary care physician who requested a CT scan of the abdomen that showed a large hepatic mass measuring 34 cm by 26 cm, replacing the majority of the liver without retroperitoneal or mesenteric lymphadenopathy (Figure 1).
CT scan 24 months after the treatment.
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CT scan of the abdomen after 4 cycles of nab-paclitaxel revealed shrinkage of the hepatic lesion to 24 x 15 cm in maximum diameter (approximately 7% decrease in the largest lesion per RECIST criteria) (Figure 2).
Liver biopsy (H&E).
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Our patient with this metastatic uveal melanoma with extensive liver metastases with GNQ-209P mutation on the tissue biopsy (Figures 3 and 4) and undetectable mutations on the peripheral blood molecular profiling in serial follow-up samples suggests marked response to nab-paclitaxel.
Liver biopsy (MART).
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Our patient with this metastatic uveal melanoma with extensive liver metastases with GNQ-209P mutation on the tissue biopsy (Figures 3 and 4) and undetectable mutations on the peripheral blood molecular profiling in serial follow-up samples suggests marked response to nab-paclitaxel.