PMC5763055_01
Histologic examination of surgically resected pulmonary carcinoid tumor shows finely granular nuclear chromatin, eosinophilic cytoplasm, and rosette formation (a) and positive expression of chromogranin A (b).
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Histopathologic examination of the surgical specimen revealed finely granular nuclear chromatin, eosinophilic cytoplasm, and rosette formation (Figure 1). The immunohistology was positive for synaptophysin, chromogranin A, and CD56 (Figure 1).
Histologic examination of a liver biopsy specimen shows a well-differentiated tumor (a) with positive expression of chromogranin A (b).
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Percutaneous liver biopsy of one of the lesions demonstrated well-differentiated tumor with positive expressions of chromogranin A, synaptophysin, and CD56 (Figure 2).
Abdominal contrast-enhanced CT shows multiple low-density areas, hepatomegaly, and metastasis to the spleen.
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Abdominal contrast-enhanced CT revealed multiple tumors in the liver and spleen, as well as hepatomegaly (Figure 3).
Immunohistochemical analysis demonstrates immunoreactivity for somatostatin receptor 2 antibody immunostaining in most tumor cells in the lung (a) and liver (b).
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Considering that immunostaining for somatostatin receptor 2 antibody was scored as 3 (circumferential membranous reactivity in >50% of tumor cells), subcutaneous octreotide therapy was started at a dose of 100 mug/day (Figure 4).