PMC9149436_01
a, b Chest CT with a 20 x 20 cm dependent necrotic mass of the left breast, left lower quadrant with signs of infiltration to the skin and the pectoral muscle associated with the presence of ipsilateral pectoral and axillary ganglia. CT, computed tomography.
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F1
Chest computed tomography revealed a necrotic mass that occupied the entire left breast parenchyma with signs of infiltration to the skin and the pectoral muscle associated with pectoral and axillary ganglia on the same side with a secondary neoplastic appearance (Fig. 1a, b).
Spindle cells with high-grade atypia and moderate mitotic (a) and Immunohistochemical staining negative for RE, PRs, HER-2, and CKs (b). PR, progesterone receptor; CK, cytokeratin; RE, estrogen receptors.
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F2
Biopsy of the lesion by tru-cut showed evidence of a high-grade malignant spindle cell neoplasm with an osteochondral component, extensive necrosis, and cytokeratins negative staining considering a phyllodes tumor of the breast versus primary breast sarcoma as a differential diagnosis (Fig. 2a). However, we consider that it would also have benefited from performing additional markers such as GLUT-1 and Claudin-1 associated with malignant perineural differentiation (Fig. 2b).