PMC3558351_01
Pathologic findings in a patient with rifampin-associated acute tubulointerstitial nephritis and Fanconi syndrome. Light microscopy revealed the extensive mononuclear cell infiltrates including epithelioid histiocytes and eosinophils, mild interstitial fibrosis and tubular atrophy (A: original magnification X 100; B: original magnification x 400). Immunofluorescent stains showed focal granular deposits of immunoglobulin A (C) and complement 3 (D) in mesangial spaces and tubules. Subendothelial electron-dense deposits (E) and expanded mesangial spaces with electron dense deposits (F) were visible using electron microscopy.
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F1
A renal biopsy showed extensive mononuclear cell infiltrates, including epithelioid histiocytes and eosinophils, mild interstitial fibrosis, and tubular atrophy (Figure 1A and B). Focal granular deposits of immunoglobulin A (IgA) and complement 3 (C3) were demonstrated in the tubules (Figure 1C and D). The same immunofluorescent positivity was also shown in glomerular mesangium, and electron microscopy showed electron-dense deposits in the subendothelial and mesangial spaces (Figure 1E and F).