PMC8149127_01
Clinical images at: A. Diagnosis; B. Initiation of radiotherapy (RT ); C. Last day of RT ; D. One month after RT ; E. Seven month after RT
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He was seen by otolaryngology and noted to have a 3cm lesion involving the left alar rim, nasal tip, and left nasal sidewall (Fig. 1A). He had an excellent initial response with 85-90% reduction in size clinically (Fig. 1B) and minimal side effects except for fatigue. Images from his first day and last day of radiation treatment are displayed in Figures 1B and 1C, respectively. He was noted to have a good response clinically on exam (Figure 1D). On 7-month follow-up, patient had finished sonidegib four months prior (total duration of 8 months) and had no residual disease clinically (Fig. 1E).
Computed tomography (CT ) images from: A. 7-month follow-up visit; B. Before radiotherapy initiation after being on sonidegib for 3 month; C. At the time of initial diagnosis. From right to left, resolution of original focal lesion can be clearly seen, as well as decreased thickening of the soft tissue over left nasal cartilage and minimal increased density of subcutaneous fat
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The patient's CT imaging over time is displayed in Figure 2.