PMC5368871_01
Plasma levels of MMP-1 and MMP-7, measured through ELISA test in patients during the follow-up before and after the surgery. *P<0.01 post-surgery vs pre-surgery.
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A 69 year-old-man with history of sub-renal abdominal aortic aneurysm (30 x 45 mm), hypertension, dyslipidemia, chronic obstructive pulmonary disease (COPD) and cardiomyopathy evaluated for the past three years in our operative unit through clinical and laboratory tests (MMPs and NGAL plasma evaluation; Fig 1-3) complained of an acute abdominal pain (Visual Analogical Scale score - VAS: 8). Moreover, during this time a significant decrease in plasma levels of MMPs and NGAL was recorded (Figs 1-3).
Plasma levels of MMP-2, MMP-9 and NGAL, measured through ELISA test in patients during the follow-up before and after the surgery. *P<0.01 post-surgery vs pre-surgery.
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A 69 year-old-man with history of sub-renal abdominal aortic aneurysm (30 x 45 mm), hypertension, dyslipidemia, chronic obstructive pulmonary disease (COPD) and cardiomyopathy evaluated for the past three years in our operative unit through clinical and laboratory tests (MMPs and NGAL plasma evaluation; Fig 1-3) complained of an acute abdominal pain (Visual Analogical Scale score - VAS: 8). III, protein C, and protein S were normal. In contrast, higher plasma levels of MMP-9 and NGAL were detected (Fig. 2). Moreover, during this time a significant decrease in plasma levels of MMPs and NGAL was recorded (Figs 1-3).
Plasma levels of MMP-3 and MMP-8, measured through ELISA test in patients during the follow-up before and after the surgery. *P<0.01 post-surgery vs pre-surgery.
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A 69 year-old-man with history of sub-renal abdominal aortic aneurysm (30 x 45 mm), hypertension, dyslipidemia, chronic obstructive pulmonary disease (COPD) and cardiomyopathy evaluated for the past three years in our operative unit through clinical and laboratory tests (MMPs and NGAL plasma evaluation; Fig 1-3) complained of an acute abdominal pain (Visual Analogical Scale score - VAS: 8). Moreover, during this time a significant decrease in plasma levels of MMPs and NGAL was recorded (Figs 1-3).
Aortic aneurysm.
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Right axillary artery aneurysm.
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MMP-s and NGAL tissue expression in healthy and in aneurysmatic segments of the patient, measured through western blot analysis on the tissues taken from axillary artery aneurysm at the time of the surgery. *P<0.01.
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Immunoblotting test performed on aneurysmal tissues from the axillary and abdominal aortic arteries taken at the time of the surgery (described in our previous study) showed increased activation of both MMP-9 and NGAL in the aortic aneurysm tissue and of all MMPs and NGAL in the axillary artery aneurysm tissue with respect to normal tissue (healthy segments of aneurysmatic vessel) (Figs 6,7).