PMC4434157_01
Entire gross specimen bivalved.
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Approximately 90% of the uterus was displaced by a soft, friable necrotic tumor that was interspersed with viable tissue suggestive of smooth muscle and measuring 14 x 11 x 9 cm (Fig. 1).
a. Osteoclast-like giant cells and pleomorphic tumor cells are distributed within prominent eosinophilic matrix (osteoid).. b. The osteoid is focally calcified, imparting the appearance of bone.
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However, on repeat pathologic evaluation, a diagnosis of primary uterine osteosarcoma based on the presence of multinucleated giant cells (Fig. 2a) and osteoid formation with ossification (Fig. 2b) was favored.