PMC3422143_01
Fundus photographs and fluorescein angiograms for case 1 with sarcoidosis. (A and B) Fundus photographs of right and left eye at initial examination. Diffuse vitreous opacities can be seen in the right eye and optic neuritis in both eyes. (C and D) Fluorescein angiograms showing dye leakage from the optic discs of both eyes. (A and C), right eye, (B and D) left eye.
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The anterior chamber was mildly inflamed, but dense vitreous opacities were present in his right eye and optic neuritis was present bilaterally (Figure 1A and B). Fluorescein angiography showed dye leakage from both optic discs (Figure 1C and D).
Vitreous cytology for case 1 with sarcoidosis. (A) Histiocytes (arrows), (B) epithelioid cells (arrows), and (C) multinucleated giant cells (arrowheads) can be seen.. Note: Necrotic materials and malignant cells are not present on Papanicolaou staining.
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Histiocytes, and epithelioid and multinucleated giant cells were detected by cytology in diluted vitreous samples, but necrotic materials and malignant cells were not detected (Figure 2).
PMC3422143_02
Fundus photographs and fluorescein angiograms for case 2 with sarcoidosis. (A and B) Fundus photographs taken at the initial examination. Numerous snowball-like vitreous opacities and optic neuritis can be seen in both eyes. (C and D) Fluorescein angiograms showing dye leakage from the optic discs and along the retinal veins in both eyes. (A and C) right eye, (B and D) left eye. vitrectomy on both eyes. Vitreous samples were obtained as in case 1. Epithelioid and multinucleated giant cells were found by vitreous cytology (Figure 4). Necrotic materials and malignant cells were not detected. Because of his poor condition, he received a posterior sub-Tenon injection of triamcinolone acetonide in both eyes instead of systemic corticosteroid therapy. One month after pars plana vitrectomy, the optic neuritis was resolved and corrected vision had improved to 20/20 OD.
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The anterior chamber was not inflamed, but numerous snowball-like vitreous opacities, optic neuritis, and periphlebitis were observed in both eyes (Figure 3A and B). Fluorescein angiography showed dye leakage from the optic discs and along the retinal veins in both eyes (Figure 3C and D).