PMC3804828_01
Soap bubble lesions, left (L) and right (R), where cement can be seen.
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He had two other soap-bubble lytic lesions of his wrists (Figure 1) on X-rays, inT1-weighted hyposignal on MRI (Figure 1, right insert).
A) HES 200x; B) anti-CD31 100x; C) HES 40x; D) CD31 40x.
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On microscopy, round epithelioid tumor cells were separated by collagenous tissue, forming dense vascular channels and solid nests without necrosis (Figure 2A). Immunohistochemistry showed strong diffuse anti-CD31 (Figure 2B), CD34, FLI1 expression in tumor cells with Ki67 60%. Histology showed poorly-differentiated angiosarcoma (Figure 2C) phenotypically comparable with his bone angiosarcoma (Figure 2D).
Comparative genomic hybridization; A) head and neck lesion; B) bone lesion.
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Genomic Hybridization (CGH) performed on paraffin-embedded tissues, as previously described, upon patient consent and FSG approval, revealed gain of chromosomes 8 and 9, consistent with angiosarcoma. Genomic profiles were similar in bone and head and neck soft-tissue lesions (Figure 3A, B) suggesting tumor clonality. The bone fragment however presented additional 12p and 18p losses (Figure 3B, arrow) (Figure 3A).