PMC5582204_01
Timeline displaying the course of clinical symptoms of case 1.
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F1
A timeline displaying the course of clinical symptoms is depicted in Figure 1.
Erosive esophagitis.
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F2
Endoscopy showed a severe, erosive esophagitis of the distal 15 cm of the esophagus (Figure 2).
Erosive gastritis.
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F3
Furthermore, a multifocal hemorrhagic antral and corporal gastritis was observed (Figure 3), next to two circular antral ulcers with a diameter of 5 mm.
Sarcina ventriculi in esophageal biopsies. These microorganisms appear to be arranged in tetrads [(A) 200x], but on higher magnification appear to be arranged in cubes composed of eight individual spheres [(B) 400x].
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F4
The bacteria were arranged in tetrad and octet groups, compatible with S. ventriculi (Figures 4A,B).
PMC5582204_02
Circular gastric ulcer.
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F5
Here, we observed a diffuse erosive gastritis and a large gastric circular ulcer with a diameter of 10 mm at the gastro-esophageal junction with no signs of esophagitis (Figure 5).
Timeline displaying the course of clinical symptoms of case 2.
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F6
A timeline with the course of clinical symptoms is depicted in Figure 6.