PMC5896657_01
Patient's clinical course.. Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; HEV-IgA, immunoglobulin A antibody against hepatitis E virus; HEV-IgM, immunoglobulin M antibody against hepatitis E virus; HEV, hepatitis E virus; n.d., not determined.
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Notably, markers of liver damage were upregulated over time (Figure 1). At that time, both HEV-IgA and HEV-IgM were positive as well as genotype 3 HEV-RNA (4.3 log copy/ mL, cutoff value: <2.0 log copy/mL; Figure 1). HEV was used. His liver function gradually improved to within the normal range, and HEV-IgA and HEV-RNA were once again negative at 11 weeks after admission (Figure 1).