PMC4782006_01
Panel A. Case 1, age 8. EEG at LGS diagnosis, showing generalized 1.5-2 Hz SSW discharges with frontal predominance, intermittent spike-waves predominating in the left occipital region, and poorly formed posterior rhythm.. Panel B. Case 1, age 12. EEG 4 years after diagnosis, showing low-amplitude background activity with infrequent low-amplitude generalized discharges and infrequent multifocal sharp waves.
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Prior to sudden unexpected death (SUDEP) at age 12 years, EEG showed low-amplitude background activity, with infrequent low-amplitude generalized discharges and infrequent multifocal sharp waves (Fig. 1, Panel B).
PMC4782006_02
PMC4782006_03
Panel A. Case 3, age 19. EEG at presentation and diagnosis, showing high-amplitude slowing with irregular high-amplitude generalized SW discharges.. Panel B. Case 3, age 12. EEG 7 years before diagnosis, showing generalized <= 1 Hz SSW discharges.. Panel C. Case 3, age 25. EEG 6 years after diagnosis, showing bursts of high-amplitude background slowing.
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The EEG findings at age 12 showed generalized background slowing and <= 1 Hz SSW discharges (Fig. 2, Panel B).
PMC4782006_04
Case 5, age 32. EEG at presentation and diagnosis, showing irregular posterior dominant 4-7 Hz rhythm and bursts of atypical 2-3 Hz SW complexes.
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Case 5 was diagnosed with LGS at age 32 years when she presented with abnormal EEG findings (Fig. 3), intractable seizures (predominantly atonic but also complex partial, focal motor, and startle-induced), mild cognitive and motor impairment, mild left hemiparesis, depression, ADD, and behavioral issues.