PMC4404870_01
Fundus imaging.. Notes: (A) Color fundus photograph (Topcon TRC 50EX), (B) red free imaging (Heidelberg Spectralis), (C) infrared imaging (Heidelberg Spectralis), and (D) fundus autofluorescence (Heidelberg Spectralis).
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Dilated fundus examination revealed numerous yellow-white retinal deposits and multifocal areas of RPE atrophy in the mid-peripheral fundus of both eyes (Figure 1A). IR imaging demonstrated an increased number of crystals compared with color fundus photography and red free images (Figure 1B and C). Fundus autofluorescence was helpful in highlighting areas of RPE atrophy, which correlated with window defects on fluorescein angiography, but failed to demonstrate crystalline deposits (Figure 1D).
Spectral domain optical coherence tomography images of both eyes through the retinal crystals.. Notes: The yellow arrows demonstrate the location of the crystals in the retina in a region of preserved outer retina (upper panel) and atrophic outer retina (lower panel).
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Line scans demonstrated hyper-reflective lesions at different layers of the retina (Figure 2).