PMC4333547_01
Hyperplastic epidermis and upper dermal well-circumscribed cystic lesion formed entirely of homogenous basophilic deposits (H and E, x100)
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F1
Histopathological examination of the nodule showed hyperplastic epidermis and upper dermal well-circumscribed focally cystic lesion [Figure 1].
(a) Variable shaped and sized large amorphous basophilic deposits (H and E, x200). (b) Closer view of calcification at dermis and epidermis (H and E, x400)
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F2
It is formed of homogenous basophilic deposits variable in shape and size ranging from large amorphous deposits, small spherules to minute fine granules [Figures 2-4] that consistent with subepidermal calcified nodule (SCN) as a variant calcinosis cutis.
(a) Large amorphous basophilic deposits, (b) Myriads of minute fine basophilic granules (H and E, x400)
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F3
It is formed of homogenous basophilic deposits variable in shape and size ranging from large amorphous deposits, small spherules to minute fine granules [Figures 2-4] that consistent with subepidermal calcified nodule (SCN) as a variant calcinosis cutis.
Calcifications ranged from large amorphous deposits (black arrows), well-formed small spherules (green circles) to small fine granules (brown arrows) (H and E, x400)
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F4
It is formed of homogenous basophilic deposits variable in shape and size ranging from large amorphous deposits, small spherules to minute fine granules [Figures 2-4] that consistent with subepidermal calcified nodule (SCN) as a variant calcinosis cutis.
(a) Black calcium deposits with three forms of calcification, (b) Predominance of large amorphous calcium, (c) and the predominance of minute fine granules (Von kossa stain, x400)
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F5
This diagnosis is confirmed by Von kossa stain that identifies the calcium in tissues as black deposits within pink background [Figure 5].