PMC2816858_01
Bone scan showing symmetric, diffuse cortical uptake around the diaphysis in both tibias and femurs. The uptake of the right ribs is attributed to tumor invasion.
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F1
Bone scan showed diffuse cortical uptake in the distal parts of both femurs and tibias (Fig. 1), and plain radiography showed subperiosteal new bone formation in the same areas (Fig. 2).
Specimen from a lung biopsy. (A) Pleomorphic polygonal cells with intracellular vascular lumina containing red blood cells (H&E, x400). (B) Tumor cells are strongly immunostained (brown color) with antibody to vascular endothelial growth factor (Hematoxylin basal stain, x400).
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F3
Immunohistochemistry staining of the tumor tissue showed the presence of vascular endothelial growth factor (VEGF) (Fig. 3).