PMC7734559_01
Immunohistochemistry of patient's tumor: (a) H&E, (b) Cytokeratin 14, (c) P63, and (d) EGFR. 200x.
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Immunohistochemical staining showed weak cytokeratin 14, p63 and GATA3 expression as well as strong staining for epidermal growth factor receptor (EGFR) (Figure 1).
Patient's tumor after three cycles of neoadjuvant AIM and surgical resection. Rare viable tumor cell amid extensive necrosis. H&E. 200x.
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The tissue pathology showed malignant spindle cell neoplasm with marked therapy effect consisting of >99% necrosis with rare scattered tumor cells present (Figure 2).