PMC4754484_01
CT scan of brain showing that the lesion has encircled both optic nerves.
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fig1
The final radiological impression was left parasellar meningioma (Figure 1).
Photomicrograph showing inflammatory nature of the lesion (H&E, x200).
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fig2
Microscopically, the tumour showed hyalinized fibrocollagenous tissue containing nodular collections of foamy histiocytes, lymphocytes, and plasma cells (Figure 2).
Photomicrograph of the lesion showing many histiocytes, some of which have engulfed intact lymphocytes (H&E, x400).
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fig3
A few foci showed emperipolesis (lymphophagocytosis by histiocytes) (Figure 3).
Photomicrograph of immunohistochemistry of the lesion showing positive reactivity of the histiocytes to S-100 protein (S-100, x400).
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fig4
Immunohistochemically, the emperipolesis histiocytes were positive for S-100 protein (Figure 4) and negative for AE1/AE3 (pan-cytokeratin), epithelial membrane antigen (EMA), vimentin, and estrogen receptor.