PMC10374292_01
Two-year-old neutered male domestic mixed breed cat kidney alterations under macroscopic examination. Note. The cat was coinfected with Feline coronavirus (FCoV), Feline immunodeficiency virus (FIV), and Feline leukemia virus (FeLV). The kidneys have irregular surfaces owing to the presence of multiple prominent and whitish millimetric nodules. The nodules are predominantly located in the renal cortex.
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The kidneys had an irregular surface due to multiple prominent, firm, whitish, and multifocal-to-coalescing millimetric nodules located predominantly in the region of the renal cortex (Figure 1).
Kidney, brain, and eye histopathology of a 2-year-old neutered male domestic mixed breed cat. Note. The cat was coinfected with Feline coronavirus (FCoV), Feline immunodeficiency virus (FIV), and Feline leukemia virus (FeLV). (A) Kidney histopathology. Loss of architecture due to the monomorphic neoplastic proliferation of small lymphocytes (asterisk). Hematoxylin and eosin (H&E) staining. (Magnification 100x, bar = 300 microm). (B) Brain histopathology. The meningeal artery showed dissociation of smooth muscle fibers and moderate adjacent pyogranulomatous inflammatory infiltrates. In the brain parenchyma, a cluster of glial cells was observed, forming a discrete glial nodule (arrow). H&E stain. (Magnification 100x, bar = 300 microm). (C) Fourth ventricle histopathology. The fourth ventricle contains red blood cells and an inflammatory infiltrate of lymphocytes, macrophages, and neutrophils associated with the fibrin mesh (asterisk) adjacent to ependymal cells. H&E stain. (Magnification 50x, bar = 500 microm). (D) Histopathological examination of the eyes. The ciliary body with increased space between smooth muscle fibers associated with discrete lymphocytic inflammatory infiltrates, red blood cells (asterisk), and fibrin (triangle). H&E stain. (Magnification 100x, bar = 300 microm).
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The diagnosis was small-cell follicular multicentric lymphoma (Figure 2A) according to. The brain sample presented pia mater with moderate focal pyogranulomatous vasculitis, characterized by the dissociation of smooth muscle fiber arteries, alteration of the tunica intima, and moderate infiltration of lymphocytes, macrophages, and neutrophils (Figure 2B). Moderate numbers of red blood cells, lymphocytes, macrophages, and neutrophils associated with fibrin and adjacent to ependymal cells were observed in the fourth ventricle, suggesting moderate pyogranulomatous ventriculitis (Figure 2C). Discrete lymphocytic inflammatory infiltrates, rare red blood cells, and moderate levels of fibrin suggested discrete uveitis (Figure 2D).