PMC8636855_01
(A) Chest X-ray before and after treatment. (B) Chest computed tomography at different time points after treatment.
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F1
C-reactive protein (CRP), 145.46 mg/L; white blood cell count (WBC), 14.73 x 109/L; platelet count, 189 x 109/L; procalcitonin (PCT), 19.36 ng/mL; D-dimer, 12.85 mug/mL; glutamic-oxaloacetic transaminase, 125 U/L; and creatinine, 39.3 mumol/L. Chest X-ray (Figure 1A) revealed bilateral lung inflammation, lung abscess in the superior lobe of the left lung, and right pleural effusion. Chest CT (Figure 1B) revealed that the lung lesions were absorbed, and the level of sCD25 and NK cell activity suggested that the condition of the patient was basically stable; therefore, the patient was discharged from the hospital.
(A)
Chlamydia psittaci detection in bronchoalveolar lavage fluid (BALF) using metagenomic next-generation sequencing (mNGS) on October 25, 2020. (B)
C. psittaci in blood detected by mNGS on October 25, 2020. (C)
C. psittaci detected in BALF using mNGS on November 4, 2020. (D)
C. psittaci in blood detected by mNGS on November 4, 2020.
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F2
October 23, 2020, the patient was examined through fiberoptic bronchoscopy, sputum and alveolar lavage fluid in the left and right bronchi were aspirated, and meropenem, vancomycin, azithromycin, and oseltamivir were administered with mechanical-assisted ventilation. On October 25, 2020, the patient received metagenomic next-generation sequencing (mNGS) (Figures 2A,B) of alveolar lavage fluid and blood, with both results indicating C. psittaci. However, the level of C. psittaci (Figures 2C,D) in the alveolar lavage fluid decreased compared to the earlier analysis, although the level of C. psittaci in the blood increased.
Timetable used to show the progress of the disease and the patient's treatment.
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F3
The telephone follow-up 1 week later revealed that the patient had no complaints of discomfort, fever, cough, or expectoration, and she was advised to conduct outpatient reviews regularly (Figure 3).