PMC8019250_01
Mucosal edema and fine-grained appearance diffusely distributed in the small intestine.
j_med-2021-0256-fig001.jpg
PMC8019250_01_j_med-2021-0256-fig001.jpg
j_med-2021-0256_fig_001
Enteroscopic findings showed mucosal edema and fine-grained appearance diffusely distributed in the proximal small intestine (Figure 1).
Histopathological findings in the jejunum biopsy: villous blunting and chronic inflammatory infiltrate in lamina propria (hematoxylin and eosin stain).
j_med-2021-0256-fig002.jpg
PMC8019250_01_j_med-2021-0256-fig002.jpg
j_med-2021-0256_fig_002
Histopathological examination of jejunum mucosal biopsies showed mucosal atrophy, villous blunting, focal dilation of the lymphatics, and mild-to-moderate chronic inflammatory cellular infiltration with the presence of CD3 cells and the absence of plasma cells (Figures 2-4).
CD3 immunostaining shows predominant T-cells infiltration in the jejunum mucosa.
j_med-2021-0256-fig003.jpg
PMC8019250_01_j_med-2021-0256-fig003.jpg
j_med-2021-0256_fig_003
Histopathological examination of jejunum mucosal biopsies showed mucosal atrophy, villous blunting, focal dilation of the lymphatics, and mild-to-moderate chronic inflammatory cellular infiltration with the presence of CD3 cells and the absence of plasma cells (Figures 2-4).
Lack of plasma cells in the lamina propria of the jejunum (CD138 immunohistochemistry).
j_med-2021-0256-fig004.jpg
PMC8019250_01_j_med-2021-0256-fig004.jpg
j_med-2021-0256_fig_004
Histopathological examination of jejunum mucosal biopsies showed mucosal atrophy, villous blunting, focal dilation of the lymphatics, and mild-to-moderate chronic inflammatory cellular infiltration with the presence of CD3 cells and the absence of plasma cells (Figures 2-4).
PMC8019250_02
Nodular changes in the descending portion of the duodenum.
j_med-2021-0256-fig005.jpg
PMC8019250_02_j_med-2021-0256-fig005.jpg
j_med-2021-0256_fig_005
Gastroscopy revealed nodular changes in the descending duodenum (Figure 5).
Histopathological findings in mucosal biopsies: (a) chronic inflammation of descending duodenum and villous blunting. (b) Biopsy from terminal ileum showing infiltration of plasma cells in the lamina propria (hematoxylin and eosin stain).
j_med-2021-0256-fig006.jpg
PMC8019250_02_j_med-2021-0256-fig006.jpg
j_med-2021-0256_fig_006
Histopathological examination of the mucosa showed villous blunting in the descending duodenum and moderate chronic inflammation in the lamina propria of both descending duodenum and terminal ileum (Figure 6a and b).
Plasma cells infiltrating in the mucosa are positive immunohistochemical staining for CD138.
j_med-2021-0256-fig007.jpg
PMC8019250_02_j_med-2021-0256-fig007.jpg
j_med-2021-0256_fig_007
The inflammatory infiltrate contains CD138+ plasma cells, some scattered CD3+ T-cells, and eosinophils (Figures 7 and 8).
Some scattered CD3+ T-cells infiltration in the lamina propria of mucosa.
j_med-2021-0256-fig008.jpg
PMC8019250_02_j_med-2021-0256-fig008.jpg
j_med-2021-0256_fig_008
The inflammatory infiltrate contains CD138+ plasma cells, some scattered CD3+ T-cells, and eosinophils (Figures 7 and 8).