PMC6364106_01
Magnetic resonance imaging. (a) Axial section shows well-defined subcutaneous soft tissue density located in the right nasolabial fold appearing isointensely on T1. (b) Hypointensity on T2. (c, d) Homogeneous enhancement after contrast.
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The lesion demonstrated isointensity with no drop in fat saturation T1 but showed hypointensity on T2 and homogeneous enhancement postcontrast (Figure 1).
Histopathological examination of the mass revealed (a) 100x microscopic image showing spindle cells proliferation, forming fascicles and whorls on a background of collagen fibres, and (b) 200x microscopic image showing mixed inflammatory cells infiltration in the background including plasma cells and eosinophils. (c) Spindle cells are focally positive for anaplastic lymphoma kinase (ALK) by immunohistochemistry. (d) Spindle cells are diffusely positive for smooth muscle actin (SMA) by immunohistochemistry.
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Moreover, immunohistochemical studies on the spindle cells revealed they are diffusely positive for vimentin and smooth muscle actin (SMA) (Figure 2) and focally positive for anaplastic lymphoma kinase (ALK).