PMC6304895_01
Chest computed tomography scan of an intrapulmonary solitary fibrous tumor, largely occupying the left hemithorax (mediastinal window).
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fig1
A chest CT scan revealed a large necrotic and heterogeneous mass occupying almost all the left hemithorax (Figure 1).
Proliferation of spindle or oval cells, arranged in a fascicular fashion with ropey collagen fibres, associated with variably dilated blood vessels often displaying staghorn-like appearance. Mitotic figures were few ((a) x100, (b) x200).
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fig2
The neoplastic cells presented a low mitotic activity (2 mitoses per high-power field) without atypia or necrosis (Figure 2).
The spindle cells show strong and diffuse positivity for (a) CD34 and (b) bcl2; (x200).
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fig3
Immunohistochemical staining was positive for CD34, bcl2 (Figure 3), and vimentin (Figure 4) but was negative for cytokeratin, SMA, desmin, and S100.
The spindle cells show positivity for vimentin (x200).
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fig4
Immunohistochemical staining was positive for CD34, bcl2 (Figure 3), and vimentin (Figure 4) but was negative for cytokeratin, SMA, desmin, and S100.
Pneumonectomy piece.
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fig5
Therefore, a pneumonectomy was performed (Figure 5).