PMC5549494_01
(a) Computed tomography of the neck. The scan with contrast enhancement shows a large heterogeneous soft tissue mass (28 mm transverse diameter), clearly defined, within the left thyroid lobe (white arrow). (b) 99mTc-MIBI scintigraphy. Early and delayed scintigrams reveal focal accumulation of increased radiotracer uptake in the left lobe of the thyroid.
CRIE2017-5376741.001.jpg
PMC5549494_01_CRIE2017-5376741.001.jpg
fig1
Contrast-enhanced CT of the neck revealed a heterogeneous soft tissue mass (28 mm transverse diameter), clearly defined, within the left thyroid (Figure 1(a)). Technetium-99m-methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy demonstrated focal accumulation of increased radiotracer uptake in the left lobe of the thyroid on both early and delayed images (Figure 1(b)).
(a) Hematoxylin-eosin stained sections of the adenoma (original magnification x4 (a-1) and x40 (a-2)). The adenoma was composed mainly of chief cells and oxyphil cells, covered with a fibrous capsule. No signs of malignancy, such as presence of capsular invasion, angioinvasion, and invasion of the surrounding structures, were observed. (b) Immunostaining for chromogranin A (brown precipitates). Section shows expression of chromogranin A. (c) Immunostaining for PTH (brown precipitates). Section shows expression of PTH.
CRIE2017-5376741.002.jpg
PMC5549494_01_CRIE2017-5376741.002.jpg
fig2
The adenoma was composed mainly of chief cells and oxyphil cells, covered with a fibrous capsule (Figure 2(a)). Evaluation of chromogranin A expression showed positive chromogranin A immunostaining (Figure 2(b)). Evaluation for PTH expression showed positive PTH immunostaining (Figure 2(c)).