PMC6393902_01
PMC6393902_02
Broad fibrous bands separate nodules of necrotic hepatic parenchyma in the setting of cirrhosis (a) and diffuse infiltration of hepatic parenchyma by lymphoma cells admixed with nonneoplastic lymphocytes (b) (H&E); CD10 (c), CD20 (d), and BCL-6 (e) immunostains are strongly and diffusely positive in lymphoma cells; Ki-67 (f) shows a high proliferative index of nearly 100% in malignant cells, which are admixed with nonneoplastic lymphocytes.
CRIPA2019-5125086.001.jpg
PMC6393902_02_CRIPA2019-5125086.001.jpg
fig1
Recut H&E- and Gomori trichrome-stained sections of liver showed the same nodules of autolyzed and necrotic hepatic parenchyma with intervening fibrous bands that were described in the original report (Figure 1(a)). There were also nodular areas of diffusely infiltrative, intermediate-sized lymphoid cells (Figure 1(b)). The interpretations in the original autopsy report are in accordance with ours after we performed selected immunohistochemistry on the recut sections (selected IHC micrographs appear in Figures 1(c)-1(f)).