PMC9058074_01
CT images of this case. CT images [(A), coronal position] [(B), sagittal position] show the tumor nodular high-density shadow in the lower lobe of the left lung, with a clear boundary, uneven internal density, and low-density vacuolar area in the center of the lesion.
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F1
The lesion had clear borders, uneven internal density, and a low-density central vacuolar area (Figure 1).
Histologic findings: hematoxylin and eosin-stained section of (A) x 100, (B) x 200, and (C) x 400 magnifications show that the tumor boundary is clear, composed of solid, slightly lobulated flake cells with consistent morphology. Scattered dilated vacuolar components can be seen in the tumor cells. (D) Tumor cells are positive for CD34. IHC x 200. (E) Tumor cells are negative for F8, and vessel positive. IHC x 200. (F) Tumor cells are weakly positive for TFE3. IHC x 200.
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F2
The nucleolus was not visible, and no necrosis or mitosis was noted (Figure 2). F8, DOG1, STAT6, ERG, ER, CAIX, and CD10 (Figure 2). Periodic acid-Schiff (PAS) staining was also negative. Fluorescent in situ hybridization (FISH) showed none Yes-associated protein 1 (YAP1)-TFE3 gene fusions.