PMC5976748_01
Neuroimaging findings in the reported case. (A) Follow-up MRI mild diffuse atrophy with more intense atrophy on the left frontal and temporal lobes and some small vessel lesions affecting periventricular and semioval white matter. (B) FDG-PET shows mild-to-severe hypometabolism on the left frontotemporal lobe junction and mild hypometabolism on the left fronto-basal, left anterior cingulum regions. (C) HMPAO SPECT shows bilateral but asymmetric hypoperfusion (more on the left side) on frontotemporal lobes. (D) Dopamine transporter-single, photon emission computed tomography was informed of the normal density ofpresynaptic dopaminergic uptakers. Some irregularities in the morphology of basal ganglia and increase of cortical uptake can be noted.
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Follow-up MRI (5 years later) showed more intense atrophy in the left frontal and temporal lobes (Figure 1A). Tc-99m-HMPAO SPECT showed bilateral but asymmetric hypoperfusion (more on the left side) on frontotemporal lobes (Figure 1B). 18F-FDG-PET showed mild to severe hypometabolism on the left frontotemporal lobe junction, and mild hypometabolism on the left fronto-basal left anterior cingulum regions (Figure 1C). DaTSPECT was informed as for the normal density of presynaptic dopaminergic uptakers (Figure 1D).