PMC4451653_01
Extraoral swelling exhibiting asymmetry and deviation of the chin
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F1
The jaw movements and the temporomandibular joint (TMJ) movements were normal [Figure 1].
Intraoral view of the swelling
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F2
The teeth present were 33, 36, 41, 42, 43, 45 and 46 with multiple missing teeth and displacement of 33, 41, 42 and 43 [Figure 2].
Preoperative orthopantomograph exhibiting an expansile swelling of the lower border of the mandible
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F3
Orthopantomograph (OPG) revealed a multilocular radiolucency extending from the right ramus to the left ramus region with an expansile swelling in the lower border of the mandible [Figure 3].
Radiograph of the resected specimen
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F4
A specimen x-ray was taken which revealed similar radiologic findings as the preoperative OPG [Figure 4].
Grossing of the specimen
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F5
Multiple sections were grossed from different areas of the specimen [Figure 5].
A richly cellular stroma with evenly dispersed giant cells (H&E, x40)
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F6
The histopathological examination of the soft tissue revealed a richly cellular stroma comprising of plenty of evenly distributed multinucleated giant cells [Figure 6].
Areas of pathologic resorption of bone (H&E stain, x200)
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F7
Few areas of pathologic resorption of bone were also evident [Figure 7].
Giant cells with agglomeration of nuclei in the center (H&E stain, x400)
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F8
High power view showed multinucleated giant cells with agglomeration of around 25-50 nuclei in center surrounded by clear cytoplasm, the proliferating stromal cells were hyperchromatic and pleomorphic [Figures 8 and 9].
A composite photomicrograph of four different fields exhibiting cellular stroma with giant cells (H&E stain, x100). Inset of each image shows high power view of the giant cell in the particular field (H&E stain, x400)
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F9
High power view showed multinucleated giant cells with agglomeration of around 25-50 nuclei in center surrounded by clear cytoplasm, the proliferating stromal cells were hyperchromatic and pleomorphic [Figures 8 and 9].