PMC7139149_01
Bronchoscopy showing neoplasms in the left main bronchus(A), left lobe bronchus(B), right main bronchus(C), and right lobe bronchus(D).
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Bronchoscopy indicated multiple tumors in the bilateral mainstem bronchi (Fig. 1).
Immunohistochemistry of the biopsied bronchial issue. Hematoxylin and eosin stained section(A,B), positive labeling with prostate-specific antigen(D) and NKX3.1(C), negative labeling with thyroid transcription factor-1(E), Original magnification x 100(A), x 400(B), x 200(C,D,E).
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Immunostaining for PSA and NKX3.1 was positive (Fig. 2C and D). The specimens demonstrated negative immunoreactivity to thyroid-transcription factor-1 (TTF-1) (Fig. 2E).
18F-FDG PET/CT was performed. Transverse CT(A,B),corresponding PET(C), and fusion(D) image showed intense FDG uptake of multiple nodules.
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PET-CT showed multiple lymph nodes in bilateral hilar and mediastinum, parts of bilateral pulmonary patchy infiltrating shadows, left iliac bone and right ischium which were all considered as distant metastases with increased FDG uptake (Fig. 3).