PMC4809469_01
Skin metastases from chondroid chordoma on the cheek and back.
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With extensive metastatic disease by September 2013, she subsequently had a firm, nontender, erythematous nodule measuring 2 x 2 cm on her left cheek (Fig 1). Three months later, she experienced disease progression, with 2 new skin lesions on the chin and frontal area and 2 new lesions on the back (Fig 1).
Staining of skin metastasis from chondroid chordoma. A, Skin with many vacuolated cells in the dermis. B, cells present a clear cytoplasm with some cells with eosinophilic cytoplasm on a chondral stroma. Some of the cells present the characteristic physaliferous cytoplasm. (A and B, Hematoxylin-eosin stain; original magnifications: A, x2; B, x10.)
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Pathologic examination found skin metastasis from chondroid chordoma, with immunohistochemical characteristics consistent with the primary tumor (Fig 2, Fig 3).
Immunohistochemistry staining. Skin metastasis from chordoma positive for pancytokeratines (A), S100 (B), epithelial membrane antigen (C), and vimentin (D).
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Pathologic examination found skin metastasis from chondroid chordoma, with immunohistochemical characteristics consistent with the primary tumor (Fig 2, Fig 3).