PMC9762516_01
Photomicrographs of the resected tumor of the right thigh revealed a solid fusocellular mesenchymal neoplasm, with: A - sclerosing and hyalinizing fibroblastic pattern, exhibiting alternating cellularity (HE, 100x); B - including hypercellular nodular areas (HE, 200x); and C - pericytic growth, evidenced by tortuous vessels with staghorn pattern (HE, 20x); D - Neoplastic cells were relatively monomorphic, exhibited a fibroblastic cytological appearance, with oval nuclei and scarce cytoplasm, low cytological grade and limited hyperchromasia (HE, 400x); Immunohistochemical analysis showed: E - positivity for CD34 (40x); and F - STAT6, nuclear pattern (200x).
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Anatomopathological features of the resected tumor of the right thigh are displayed in Figure 1.
MRI scans in axial planes show multiple hepatic nodules distributed over both lobes. A - (T2-weighted sequence), the largest hypervascularized with extensive central necrosis, measuring 11.2 x 8.8 cm in segment VII/VII; B - (DCE sequence) and in segment III, measuring 12.5 x 9.3 cm; C - (DCE portal sequence); D - osteolytic lesions in the vertebral body of D4 (T2-weighted sequence in the sagittal plane), with a soft tissue component determining compression on the dural sac.
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Imaging studies documented more than ten liver nodules, the largest in segments III (12.5 x 9.3 cm) and VII/VIII (11.2 x 8.8 cm), and osteolytic lesions in the vertebral bodies of D4 and L3, suggestive of metastases (Figure 2).
Photomicrographs of the percutaneous liver biopsy showed: A - monomorphic and fibrosclerosing proliferative mesenchymal lesion with alternating cellularity (HE, 20x); B - including hypercellular areas (HE, 100x); C - with poorly defined cellular arrangement (HE, 40x); D - some ectatic vessels with hyalinized wall (HE, 100x). Immunohistochemical examination showed: E - consistent positivity for CD34 (100x); F - STAT6, nuclear pattern (400x).
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Percutaneous liver biopsy confirmed hepatic metastases of SFT (Figure 3).