PMC3303706_01
Baseline QTc. QTc interval was normal prior to amiodarone administration (day 0); after 1.65g intravenous amiodarone, QTc increased progressively.
CRIM2012-673019.001.jpg
PMC3303706_01_CRIM2012-673019.001.jpg
fig1
A 57-year-old male, with unremarkable cardiovascular history, had a self-terminated episode of atrial fibrillation (Figure 1) one day prior to surgery for hiatus hernia. Sinus rhythm was restored after 1 hour, but drug administration was continued for 12 hours, with a total amiodarone dosage of 1.65 g (Figure 1). 
Torsade de pointes after amiodarone administration.
CRIM2012-673019.002.jpg
PMC3303706_01_CRIM2012-673019.002.jpg
fig2
Approximately 48 hours after amiodarone administration, torsade de pointes was recorded (Figure 2) and prompt defibrillation restored sinus rhythm.
Time course of QTc prolongation. QTc prolongation persisted for 14 days after cessation of intravenous amiodarone. Note the (marginally) low serum K+ on the 4th hospital day.
CRIM2012-673019.003.jpg
PMC3303706_01_CRIM2012-673019.003.jpg
fig3
However, prolonged hospitalization was required, because QTc prolongation persisted until the 14th hospital day (Figure 3).
12-lead ECG at discharge. Prior to discharge, the QTc interval was 470 ms.
CRIM2012-673019.004.jpg
PMC3303706_01_CRIM2012-673019.004.jpg
fig4
The patient was discharged home on the 15th hospital day, at which point a QTc interval of 470 ms was recorded (Figure 4).