PMC8358395_01
Cardiopathological findings. (A) Morphology of the heart showing multifocal inflammatory infiltrates consisting of neutrophilic granulocytes, lymphocytes and histiocytes, capillarostasis, and perifocal single-cell necroses of cardiomyocytes (arrow) (H&E, x400). (B,C) Immunohistochemical staining for fibrin demonstrating cross section and longitudinal section of capillaries with prominent microthrombi occluding the lumens (immunohistochemistry for fibrin, x400).
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F1
Most notably, the heart presented as normotrophic and irregularly perfused with mild diffuse necrotizing myocarditis (Figure 1A) accompanied by extensive thrombotic microangiopathy of cardiac capillaries (Figures 1B,C; microthrombi in cardiac capillaries immunohistochemically stained for fibrin), which was determined as the cause of death.