PMC2836174_01
Anterior view of dermatofibroma (10.5 cm  x  10 cm  x  6 cm) in the right inguinal region. Ulcerated area is covered with tegapore dressing.
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fig1
The centre was ulcerated discharging pus (Figure 1).
Axial computed-tomography view of dermatofibroma (arrowed) arising from the skin of the right base of the scrotum demonstrating a complex cystic structure with fluid and septations.
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fig2
Computed tomography of the lesion showed a complex cystic structure with fluid and septations containing several foci of calcification (Figure 2).
Excised tissue, sliced longitudinally, showing cystic and haemorrhagic areas.
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fig3
On slicing, a well-circumscribed multilobulated mass with a variegated cut surface including cystic and haemorrhagic areas was apparent (Figure 3).
On low power the lesion is composed of spindled cells in the dermis with a well defined Grenz zone; H&E stain, moderate magnification x40. On high power, bundles of interlacing spindle cells in the dermis. H&E stain, magnification x100. Same area of lesion as in (b) stained for Factor XIIIa, showing diffuse staining with scattered strongly positive cells; Factor XIIIa stain, magnification x100. High powered section of specimen showing cholesterol clefting and scattered giant cells; H&E stain, magnification x100
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fig4
At the centre of the lesion there were areas of cystic degeneration with focal haemorrhage, cholesterol clefting, and giant cells with focal calcification (Figure 4).