PMC8381346_01
Histopathology of COVID-19-induced hepatitis. a Mild expansion of portal tracts by chronic inflammatory cells with mild interface hepatitis and mild periportal fibrosis (H&E x 100). b Higher power showing numerous pale intracytoplasmic eosinophilic globules (H&E x 400). c The globules were highlighted by trichrome stain as light blue globules (MT x 400). d The globules faded after staining with periodic acid-Schiff-diastase stain (PAS-D x 400). e Lack of copper associated globules within hepatocytes and negative staining of the globules (Orcein x 400). f Lack of iron deposition within hepatocytes and negative staining for the globules (Perls Prussian blue x 400)
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Fig1
The globules were positive for masson trichrome stain and negative for periodic acid Schiff-diastase (PAS-D), orcein, and perls stains (Fig. 1).