PMC5821986_01
(a to d) Large, warm, erythematous, nontender plaques and subcutaneous nodules on the edematous right leg and ankle in a renal transplant recipient on admission. (e and f) Hematoxylin and eosin shows fat necrosis and coagulative necrosis and rare foci of vasculitis as well as foci of RBC extravasation.
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fig1
The nodules were painful and warm, and the skin over the nodules consisted of focal superficial ulcerations (Figure 1). Sanguineous and purulent exudative materials were observed from both margins and center of the lesion (Figure 1).
Rapid deterioration of ulcers and increase in the lesion size after 2 weeks.
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fig2
Over a period of a few days, her condition deteriorated, and the ulcerative area rapidly increased in size (Figure 2).
(a) Periodic acid-Schiff (PAS), (b) alcian blue, and (c) colloidal iron stains were positive, but (d) Giemsa and (e) Prussian blue stains were negative for cryptococcus. (f) Mucicarmine stain was positive for cryptococcosis.
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fig3
Giemsa and Prussian blue stains were negative (Figure 3).