PMC5045451_01
Anterior segment photography of a conjunctival hypertrophic scar at preoperative (a), immediate postoperative (b), and 14 days postoperative (c)
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Fig1
There was no associated pigmentation, ulceration, or tenderness (Fig. 1a). Excisional biopsy of the benign conjunctival tumor was performed using radiofrequency electrosurgical systems (Ellman International Inc., Oceanside, NY) under local anesthesia (Fig. 1b). The region of the excised conjunctiva was well-healed on postoperative day 14 (Fig. 1c), and there was no recurrence until 1 year post-surgery.
Histopathological examinations (a-c) demonstrated the diffuse proliferation and infiltration of collagenous fibrous bundles (hematoxylin and eosin, x40, x100, x400). Spindle-shaped fibroblasts are positive for CD34 (d; immunohistochemical staining, x400) and negative for smooth muscle actin (e; immunohistochemical staining, x400). The excessive collagenous tissue is stained blue (f; Masson's trichrome staining, x200)
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Fig2
On microscopic examination, the lesion was composed of spindle-shaped fibroblasts and collagenous stroma (hematoxylin & eosin stain, 40x, Fig. 2a). A section of the specimen showed thick, interlacing, collagenous fibrous bundles oriented in random directions and fibroblastic proliferation (Fig. 2b, c). The excessive collagenous tissue was stained blue by Masson trichrome stain (Fig. 2d-f).