PMC10065417_01
Sweet syndrome manifestation (A) edematous erythema on the left lower eyelid with a central blister; (B) Facial skin lesions subsided 1 month after treatment (C) Histopathological examination of the skin lesion (HE 40x) showed slightly increased epidermis thick, diffuse infiltration of lymphocytes and neutrophils in the superficial dermis, vasodilation and congestion.
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Three days later, several rice-sized red papules appeared on her left lower eyelid, gradually forming a painful edematous erythema with a central blister (Figure 1A), with pressure pain and no exudation. A skin biopsy was performed and showed slight thickening of the epidermis, diffuse lymphocytic and neutrophilic infiltration in the superficial dermis, and dilated and congested blood vessels (Figure 1C). The patient was treated with topical dexamethasone and the erythema gradually disappeared (Figure 1B) but symptoms of bone pain persisted.
Imaging examination of SAPHO syndrome (A and B) X-ray and CT examination showed diffuse bone thickening in the upper and lower segments of the right fibula. (C and D) MRI examination suggested limited bone marrow edema in the right fibula; (E and F) 99mTc-MDP whole-body bone scintigraphy showed abnormal radioactive concentrations on the right fibula, and fusion tomography demonstrated thickening of the bone cortex.
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X-ray and CT examination (Figure 2A and B) showed diffuse bone thickening in the upper and lower segments of the right fibula, suggesting chronic osteomyelitis; MRI examination (Figure 2C and D) suggested limited bone marrow edema in the right fibula; 99mTc-MDP whole-body bone scintigraphy (Figure 2E and F) showed abnormal radioactive concentrations on the right fibula, and fusion tomography demonstrated thickening of the bone cortex, suggesting an inflammatory lesion.