PMC4921188_01
Lower-extremity noncontrast, low-dose axial CT image of lower extremities demonstrates 2.9 x 1.8 x 3.7-cm soft-tissue mass along medial aspect of left calf within the superficial subcutaneous soft tissues. The longest diameter in the coronal plane is 3.6 cm, in the sagittal plane 3.6 cm, and in the transaxial 3.2 cm.
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The noncontrast computerized tomographic (CT) scan demonstrated a 2.9 x 1.8 x 3.7-cm soft-tissue mass along the medial aspect of the left calf within the superficial subcutaneous soft tissues (Fig. 1).
Coregistration of transaxial CT images with 18FDG PET images. Intense pathological FDG uptake (SUV 9.1) is present on initial 18FDG PET examination coregistering with superficial soft-tissue mass, consistent with biologic tumor activity.
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There were no other sites of abnormal 18F-FDG uptake (Fig. 2, Fig. 3).
Pathological specime n.A. Well-differentiated sebaceous carcinoma composed of lobules and sheets of tumor cells with central necrosis (40 X). B. Individual cells have distinct cell membranes, clear to vacuolated cytoplasm, vesicular nuclei with prominent nucleoli and mitotic figures (400X).
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However, perineural or vascular invasion was not seen (Fig. 4).
Subsequent coregistered 18FDG PET CT coronal image post excision and radiotherapy shows no residual areas of abnormal 18FDG uptake consistent with good treatment response.
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