PMC6882281_01
Pedigree chart of the family. The arrow represents the proband. Squares represent males, and circles represent females. The diagonal lines represent deceased family members. Black squares or circles indicate the members with FHM. White squares or circles represent members without FHM.
fneur-10-01221-g0001.jpg
PMC6882281_06_fneur-10-01221-g0001.jpg
F1
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Brain MRI of the proband. Note the presence of obvious cerebellar atrophy.
fneur-10-01221-g0002.jpg
PMC6882281_06_fneur-10-01221-g0002.jpg
F2
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Sequencing map of the CACNA1A gene in the FHM family. All seven living members with FHM carried the T666M mutation in the CACNA1A gene (the C  T replacement in exon 16 leads to athreonine-for-methionine substitution of amino acid 666). And four unaffected relatives did not contain the same mutation. The one-to-one correspondence between pictures and family members is that (A) matches the proband II-8, (B) matches III-12, (C) matches III-13, (D) matches II-10, (E) matches II-6, (F) matches III-1, (G) matches III-2, (H) matches III-3, (I) matches III-4, (J) matches IV-4 and (K) matches IV-3.
fneur-10-01221-g0003.jpg
PMC6882281_06_fneur-10-01221-g0003.jpg
F3
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech. T666M mutation in CACNA1A genes. This pathogenic mutation was absent in four unaffected relatives (Figure 3).
PMC6882281_02
Pedigree chart of the family. The arrow represents the proband. Squares represent males, and circles represent females. The diagonal lines represent deceased family members. Black squares or circles indicate the members with FHM. White squares or circles represent members without FHM.
fneur-10-01221-g0001.jpg
PMC6882281_06_fneur-10-01221-g0001.jpg
F1
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Brain MRI of the proband. Note the presence of obvious cerebellar atrophy.
fneur-10-01221-g0002.jpg
PMC6882281_06_fneur-10-01221-g0002.jpg
F2
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Sequencing map of the CACNA1A gene in the FHM family. All seven living members with FHM carried the T666M mutation in the CACNA1A gene (the C  T replacement in exon 16 leads to athreonine-for-methionine substitution of amino acid 666). And four unaffected relatives did not contain the same mutation. The one-to-one correspondence between pictures and family members is that (A) matches the proband II-8, (B) matches III-12, (C) matches III-13, (D) matches II-10, (E) matches II-6, (F) matches III-1, (G) matches III-2, (H) matches III-3, (I) matches III-4, (J) matches IV-4 and (K) matches IV-3.
fneur-10-01221-g0003.jpg
PMC6882281_06_fneur-10-01221-g0003.jpg
F3
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech. T666M mutation in CACNA1A genes. This pathogenic mutation was absent in four unaffected relatives (Figure 3).
PMC6882281_03
Pedigree chart of the family. The arrow represents the proband. Squares represent males, and circles represent females. The diagonal lines represent deceased family members. Black squares or circles indicate the members with FHM. White squares or circles represent members without FHM.
fneur-10-01221-g0001.jpg
PMC6882281_06_fneur-10-01221-g0001.jpg
F1
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Brain MRI of the proband. Note the presence of obvious cerebellar atrophy.
fneur-10-01221-g0002.jpg
PMC6882281_06_fneur-10-01221-g0002.jpg
F2
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Sequencing map of the CACNA1A gene in the FHM family. All seven living members with FHM carried the T666M mutation in the CACNA1A gene (the C  T replacement in exon 16 leads to athreonine-for-methionine substitution of amino acid 666). And four unaffected relatives did not contain the same mutation. The one-to-one correspondence between pictures and family members is that (A) matches the proband II-8, (B) matches III-12, (C) matches III-13, (D) matches II-10, (E) matches II-6, (F) matches III-1, (G) matches III-2, (H) matches III-3, (I) matches III-4, (J) matches IV-4 and (K) matches IV-3.
fneur-10-01221-g0003.jpg
PMC6882281_06_fneur-10-01221-g0003.jpg
F3
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech. T666M mutation in CACNA1A genes. This pathogenic mutation was absent in four unaffected relatives (Figure 3).
PMC6882281_04
Pedigree chart of the family. The arrow represents the proband. Squares represent males, and circles represent females. The diagonal lines represent deceased family members. Black squares or circles indicate the members with FHM. White squares or circles represent members without FHM.
fneur-10-01221-g0001.jpg
PMC6882281_06_fneur-10-01221-g0001.jpg
F1
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
PMC6882281_05
Pedigree chart of the family. The arrow represents the proband. Squares represent males, and circles represent females. The diagonal lines represent deceased family members. Black squares or circles indicate the members with FHM. White squares or circles represent members without FHM.
fneur-10-01221-g0001.jpg
PMC6882281_06_fneur-10-01221-g0001.jpg
F1
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Brain MRI of the proband. Note the presence of obvious cerebellar atrophy.
fneur-10-01221-g0002.jpg
PMC6882281_06_fneur-10-01221-g0002.jpg
F2
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
PMC6882281_06
Pedigree chart of the family. The arrow represents the proband. Squares represent males, and circles represent females. The diagonal lines represent deceased family members. Black squares or circles indicate the members with FHM. White squares or circles represent members without FHM.
fneur-10-01221-g0001.jpg
PMC6882281_06_fneur-10-01221-g0001.jpg
F1
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Brain MRI of the proband. Note the presence of obvious cerebellar atrophy.
fneur-10-01221-g0002.jpg
PMC6882281_06_fneur-10-01221-g0002.jpg
F2
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech.
Sequencing map of the CACNA1A gene in the FHM family. All seven living members with FHM carried the T666M mutation in the CACNA1A gene (the C  T replacement in exon 16 leads to athreonine-for-methionine substitution of amino acid 666). And four unaffected relatives did not contain the same mutation. The one-to-one correspondence between pictures and family members is that (A) matches the proband II-8, (B) matches III-12, (C) matches III-13, (D) matches II-10, (E) matches II-6, (F) matches III-1, (G) matches III-2, (H) matches III-3, (I) matches III-4, (J) matches IV-4 and (K) matches IV-3.
fneur-10-01221-g0003.jpg
PMC6882281_06_fneur-10-01221-g0003.jpg
F3
Another daughter of the proband's eldest sister (Figure 1, III-3) is 47 years old. Her daughter (Figure 1, IV-3), a 26-year-old girl, manifested temporary hemiplegic migraine and persistently slurred speech. T666M mutation in CACNA1A genes. This pathogenic mutation was absent in four unaffected relatives (Figure 3).