PMC9082154_01
a Well-circumscribed infiltrated plaque on the glabella with partial alopecia of the left eyebrow. b 6 months after treatment with pimecrolimus and excimer lamp phototherapy.
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F1
A healthy 3-year-old boy presented with a 3-month history of an asymptomatic, well-circumscribed indurated rounded plaque (4 cm in diameter), located on his glabellar forehead, with follicular prominence and mild scales at places (Fig. 1a). The infiltrated plaque started thinning out gradually and resolved completely (Fig. 1b) over 6 months (25 sessions of excimer light therapy).
a: H&E 10 X: Patchy perivascular and dense perifollicular infiltrate of lymphocytes with folliculotrophism. b 40 X: Moderate reticular follicular epithelial degeneration with intercellular stands of bluish staining mucin. c Alcian blue 40 X: mucinous degeneration and mucin deposits.
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F2
Skin biopsy showed (Fig. 2a, b) patchy lichenoid and dense perifollicular lymphocytic infiltrate, with clustering of lymphocytes in the outer root sheath of the hair follicles (folliculotropism). Follicular epithelium showed moderate reticular epithelial degeneration with intercellular stands of bluish stained mucin confirmed with Alcian blue stain (Fig. 2).