PMC8475649_01
(A) Clinical characteristics of our patient at presentation, 3 and 7 months after therapy initiation. (B) ngTIN in our patient, 20x magnification, hematoxylin and eosin (HE) stain. (C) Course of treatment in our patient. d, day; w, week; m, months; MP, methylprednisolone; PRED, prednisolone; MTX, methotrexate.
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F1
Basic laboratory studies including blood count and blood gas analysis were normal besides elevated inflammatory parameters [C-reactive protein (CrP), 17.9 mg/dl; erythrocyte sedimentation rate (ESR), 87 mm/h] (Figure 1A). The kidney biopsy showed interstitial nephritis with predominantly CD3-positive T cells, but also granulocyte infiltration and acute tubular epithelial damage (Figure 1B). Prednisolone was slowly tapered, aiming for a 6-month period to achieve the maintenance dose of 5 mg daily (Figure 1C).