PMC6395054_01
Radiographs of posterior spinal correction surgery.. Notes: She underwent posterior spinal correction surgery for scoliosis at 12 years of age. Radiographs show (A) anterior-posterior view and (B) lateral view.
tcrm-15-303Fig1.jpg
PMC6395054_01_tcrm-15-303Fig1.jpg
f1-tcrm-15-303
She underwent posterior spinal correction surgery for scoliosis at 12 years of age (Figure 1).
The change of bone turnover markers.. Notes: Serum TRACP-5b and urinary type I collagen amino-terminal telopeptide greatly decreased after the first administration. Serum bone-specific alkaline phosphatase and type I procollagen N-terminal propeptide decreased as well, while the whole-parathyroid hormone and 1-alpha, 25-dihydroxyvitamin D3 increased.. Abbreviations: BAP, bone-specific alkaline phosphatase; PINP, type I procollagen N-terminal propeptide; NTX, type I collagen amino-terminal telopeptide; TRACP-5b, tartrate-resistant acid phosphatase 5b.
tcrm-15-303Fig2.jpg
PMC6395054_01_tcrm-15-303Fig2.jpg
f2-tcrm-15-303
Serum tartrate-resistant acid phosphatase 5b (TRACP-5b) and urinary type I collagen amino-terminal telopeptide (NTX) greatly decreased after the first administration (Figure 2). Serum bone-specific alkaline phosphatase (BAP) and type I procollagen N-terminal propeptide (PINP) decreased as well, while the whole-parathyroid hormone (PTH) and 1-alpha, 25-dihydroxyvitamin D3 (1,25[OH]2D) increased (Figure 2).
The change of bone mineral density (BMD).. Notes: At 13 months of denosumab treatment, her total hip BMD T-score improved from -2.3 to -2.0, and the BMD increased by 4.5% for total hips at the end of our study. The change of femoral neck BMD was also similar.
tcrm-15-303Fig3.jpg
PMC6395054_01_tcrm-15-303Fig3.jpg
f3-tcrm-15-303
T-score (the number of standard deviations above (+) or below (-) mean peak young adult BMD) improved from -2.3 to -2.0, and the BMD increased by 4.5% for total hips at the end of our study (Figure 3). The change of femoral neck BMD was also similar (Figure 3). There were no fractures and falls during the treatment period.