PMC10359812_01
Patients' most recent MRI examinations. First row-Pt1: (A) (sagittal 3D T1-weighted image) shows thinning of the corpus callosum, reflecting brain volume reduction, and compensatory thickening of the skull (arrow). (B) (axial T2 weighted image) shows an overall slight reduction in white matter volume with moderately enlarged subarachnoid spaces. (C) (axial T2 weighted image), at the level of temporal poles, shows subcortical white matter signal hyperintensity (arrows). (D) (axial 3D-T1 weighted image), at the same level, shows a normal signal intensity of the subcortical white matter (arrow). Second row-Pt2: (E) (sagittal 3D T1-weighted image) shows microcephaly with thinning of the corpus callosum reflecting brain volume reduction. (F) (axial T2 weighted images) shows a diffuse reduction in white matter volume with moderate enlargement of the lateral ventricles and subarachnoid spaces. Diffuse blurring of the white matter signal is also evident in both hemispheres (asterisks). (G) (axial T2 weighted images), at the level of temporal poles, shows subcortical white matter signal hyperintensity (arrows). (H) (axial 3D-T1 weighted image), at the same level, shows a normal signal intensity of the subcortical white matter (arrow).
fneur-14-1181015-g0001.jpg
PMC10359812_02_fneur-14-1181015-g0001.jpg
F1
At 14 years, the brain MRI showed a slight expansion of the supratentorial cortical spaces, indicating brain atrophy progression (Figure 1).
PMC10359812_02
Patients' most recent MRI examinations. First row-Pt1: (A) (sagittal 3D T1-weighted image) shows thinning of the corpus callosum, reflecting brain volume reduction, and compensatory thickening of the skull (arrow). (B) (axial T2 weighted image) shows an overall slight reduction in white matter volume with moderately enlarged subarachnoid spaces. (C) (axial T2 weighted image), at the level of temporal poles, shows subcortical white matter signal hyperintensity (arrows). (D) (axial 3D-T1 weighted image), at the same level, shows a normal signal intensity of the subcortical white matter (arrow). Second row-Pt2: (E) (sagittal 3D T1-weighted image) shows microcephaly with thinning of the corpus callosum reflecting brain volume reduction. (F) (axial T2 weighted images) shows a diffuse reduction in white matter volume with moderate enlargement of the lateral ventricles and subarachnoid spaces. Diffuse blurring of the white matter signal is also evident in both hemispheres (asterisks). (G) (axial T2 weighted images), at the level of temporal poles, shows subcortical white matter signal hyperintensity (arrows). (H) (axial 3D-T1 weighted image), at the same level, shows a normal signal intensity of the subcortical white matter (arrow).
fneur-14-1181015-g0001.jpg
PMC10359812_02_fneur-14-1181015-g0001.jpg
F1
At 14 years, the brain MRI showed a slight expansion of the supratentorial cortical spaces, indicating brain atrophy progression (Figure 1).