PMC7641008_01
Clinical Opiate Withdrawal Scale Scores over time. Naltrexone was administered at time = 0. Withdrawal symptoms were assessed using the COWS every 15 minutes until rescue with buprenorphine, which was administered at 60, 75, 120, and 360 minutes. An additional 8 mg buprenorphine was administered at 600 minutes.
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F1
Assessment of withdrawal symptoms was conducted every 15 minutes thereafter (Figure 1). A dose of buprenorphine 8 mg was then administered sublingually (Figure 1 and Table 1).