PMC3922991_01
CT scan large mass in the right lobe of thyroid grand invasive to the upper mediastinum.
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PMC3922991_01_40064_2013_810_Fig1_HTML.jpg
Fig1
CT scans revealed a sizable lesion with imaging features of a submerged goiter, invasive to the upper mediastinum (diameter = 66 mm) with no enlarged mediastinal or axillary lymph nodes (Figures  1: large mass in the right lobe of thyroid grand invasive to the upper mediastinum).
H-E staining showing both thyroid follicles in the down left part and tumor cells in the upper right part, original magnification x100.
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Fig2
The tumor consisted of uniform, small to medium sized cells with a round nucleus, finely dispersed chromatin, inconspicuous nucleoli and scant cytoplasm (Figure  2: hematoxylin-eosin-staining H-E showing both thyroid follicles in the down left part and tumor cells in the upper right part, original magnification x100).
Immunoperoxidase staining for CK20 showing positive tumor cells, original magnification x400.
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Fig3
The tumor was characterized of positive immunohistochemical reaction for antibodies to cytokeratin CAM 5.2, cytokeratin 20 CK20 (Figure  3: immunoperoxidase staining for CK20 showing positive tumor cells, original magnification x400), neurofilaments NF (Figure  4: immunoperoxidase staining for NF showing positive tumor cells, original magnification x400) and neuroendocrine markers chromogranin, synaptophysin and CD56.
Immunoperoxidase staining for NF showing positive tumor cells, original magnification x400.
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PMC3922991_01_40064_2013_810_Fig4_HTML.jpg
Fig4
The tumor was characterized of positive immunohistochemical reaction for antibodies to cytokeratin CAM 5.2, cytokeratin 20 CK20 (Figure  3: immunoperoxidase staining for CK20 showing positive tumor cells, original magnification x400), neurofilaments NF (Figure  4: immunoperoxidase staining for NF showing positive tumor cells, original magnification x400) and neuroendocrine markers chromogranin, synaptophysin and CD56.