PMC6287090_01
Patient observed initially (A) and 5 months after consolidation therapy (B).
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PMC6287090_01_gr1.jpg
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In June 2017, the patient returned to the clinic with similar lesions on the temples with additional widespread, asymptomatic erythematous papules on the trunk and lower extremities (Fig 1, A). Two cycles of therapy resulted in a marked decrease in his number of skin lesions (Fig 1, B) and resolution of his widespread lymphadenopathy.
A, Biopsy findings show a diffuse infiltrate of mononuclear cells with abundant pale cytoplasm in the papillary dermis. B, On higher power, histiocytes with abundant cytoplasm and conspicuous nucleoli (red arrows) and emperiopolesis of lymphocytes and neutrophils (black arrows) are seen. C, S100+ staining of histiocytes. D, Higher-power view of S100+ histiocytes with negative staining of intracytoplasmic hematolymphoid cells (arrows).
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fig2
Three skin biopsy specimens were taken from the left central temple, the left lower back, and right medial distal pretibial region (Fig 2).