PMC4936467_01
Fine needle aspiration cytology smear (Hematoxylin and Eosin, x400). a) Showing clusters of malignant breast duct epithelial cells with pleomorphic nuclei, raised N:C ratio and clumped chromatin with prominent nucleoli; b) granulomas composed of epithelioid cells, lymphocytes and macrophages
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Fine needle aspiration cytology (FNAC) showed clusters of malignant duct epithelial cells having raised nuclear : cytoplasmic ratio, pleomorphic nuclei with clumped chromatin and prominent nucleoli [Figure 1a]. Apart from this, many epithelioid cell granulomas and caseous necrosis were also seen [Figure 1b].
Histopathologic findings of the resected specimen with axillary lymph nodes, Hematoxylin and Eosin. a) Section showing cords and nests of malignant ductal cells along with a granuloma showing Langerhans giant cell (x100); b) High-power view of the granuloma (x400).
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The resected specimen with axillary lymph nodes was sent for histopathology, which showed sheets, tubules and individually scattered malignant cells along with many granulomas composed of epithelioid cells, lymphocytes and Langerhans type of giant cells with central caseous necrosis [Figure 2a,b].