PMC9875631_01
(A) Lymph node histopathology, (B) lymph node immunohistochemistry for TDT, (C) is lymph node immunohistochemistry staining for CD7, (D) is lymph node immunohistochemistry for CD3, (E) shows a hypercellular marrow pre-treatment and (F) is a negative TdT staining at diagnosis
CNR2-6-e1769-g004.jpg
PMC9875631_01_CNR2-6-e1769-g004.jpg
cnr21769-fig-0001
Excisional biopsy from the Rt inguinal LN: T-lymphoblastic Lymphoma (TLL), positive for CD3, CD2, CD7, TDT as shown in Figure 1.
Demonstrates peripheral eosinophilia with dysplasia and hypogranulation
CNR2-6-e1769-g002.jpg
PMC9875631_01_CNR2-6-e1769-g002.jpg
cnr21769-fig-0002
Blood Film: WBC showed absolute eosinophilias shown in Figure 2, with eosinophils showing dysplasia and hypogranulation.
Shows interstitial deletion of CHIC2 gene found on FISH using FIP1L1/CHIC2/PDGFRA probe
CNR2-6-e1769-g005.jpg
PMC9875631_01_CNR2-6-e1769-g005.jpg
cnr21769-fig-0003
Fluorescence In Situ Hybridization (FISH) from peripheral blood: FIP1L1/CHIC2/PDGFRA: 70% interstitial deletion detected (Figure 3).
A transverse view of FDG PET showing a hypermetabolic right external iliac and inguinal lymph nodes with SUV max 15.8
CNR2-6-e1769-g001.jpg
PMC9875631_01_CNR2-6-e1769-g001.jpg
cnr21769-fig-0004