PMC4291576_01
Dense collections of large cells with abundant eosinophilic cytoplasmic inclusions of fibrillar to crystalloid shape (A, B; HE 20x and 40x). Immunohistochemistry reveals their phagocytic lineage with strong expression of CD68 (C, 20x), whereas they are largely negative for GFAP (D, 20x).
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Figure1
Upon histology, large collections of pleomorphic cells with intracytoplasmic fibrillar and crystalloid inclusions (Figure 1A, B) were apparent. The immunoprofile with prominent reactivity for macrophage-associated CD68 (Figure 1C) and lack of glial fibrillary acidic protein (Figure 1D) suggested the diagnosis of CSH.