PMC5259930_01
Bronchial washing cytology shows bronchial epithelial cells and mixed acute and chronic inflammatory infiltrate, including numerous histiocytes. Most histiocytes were packed with many yeast-like organisms (Pap, x400) with inset showing oval to oblong in shape with central transverse septum (GMS, x1000)
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F1
Most histiocytes were packed with many yeast-like organisms measuring 3mm in diameter that stained dark brown on methenamine silver (GMS) stain [Figure 1]. The most characteristic feature was a central transverse septum that was transparent with Papanicolaou stain but highlighted by GMS stain [Figure 1].
Bronchoscopic biopsy shows diffuse histiocytic proliferation with organisms in submucosa. (H&E, x400)
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F2
In Hematoxylin and eosin (H and E)-stained sections, the organisms were seen as nonbudding round-to-oval spherules within the histiocytes in the submucosa of bronchi [Figure 2].