PMC3586447_01
Computed tomography (CT) of paranasal sinuses and orbit showing mass (arrow) occupying the entire left ethmoid and sphenoid sinus extending into left nasal cavity causing erosion of nasal septum, extending into orbit and intracranial extension into basifrontal area (before chemoradiation and after chemoradiation).
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Computed tomography (CT) of paranasal sinuses and orbit revealed soft-tissue mass occupying the entire left ethmoid and sphenoid sinus extending into left nasal cavity causing erosion of nasal septum, extending into orbit and intracranial extension into basifrontal area (Figure 1(a)). Reassessment showed that the tumour had regressed completely (Figure 1(b)).
(haematoxylin and eosin x100): Showing poorly differentiated malignant neoplasm with neuroendocrine differentiation.
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fig2
Biopsy from nasal mass was reported as poorly differentiated malignant neoplasm with neuroendocrine differentiation (Figure 2).
Neuroendocrine cells showing synaptophysin positivity (arrow). (Immunoperoxidase technique, HPR polymerase method x100.)
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Immunohistochemistry (IHC) revealed that neoplastic cells were positive for cytokeratin, synaptophysin, and chromogranin and negative for S-100 (Figure 3).