PMC10249011_01
CT images at the first presentation.. Random-pattern bilateral pulmonary nodules and multiple mediastinal lymphadenopathies are noted.
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Computerized tomography (CT) examination (Fig. 1), revealed random bilateral pulmonary nodules and multiple mediastinal lymphadenopathies.
Hematoxylin-Eosin (HE) -stained microscopic image of the bronchoscopy biopsy specimen collected in TBLB.. Non-necrotizing granulomas and epithelioids are present. Small nodular lesion of aggregation of non-necrotizing epithelioid cell granulomas with lymphocyte rim are present.
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Transbronchial lung biopsy (TBLB) reports indicated multiple epithelioid granulomas in the interstitium throughout the alveoli (Fig. 2).
A HE-stained specimen of the right upper arm lesion.. Epithelioid granulomatous lesions form a 5 mm by 3 mm tubercle in the subcutaneous tissue.
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Biopsy of the subcutaneous nodule in the right upper arm revealed epithelioid granulomas (Fig. 3).
Lung field lesions before (on the left) and after (on the right) dupilumab cessation.. Arrows indicate one of the improved lesions.
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Pulmonary nodules and multiple mediastinal lymphadenopathies also reduced in size (Fig. 4, Fig. 5).