PMC10444195_01
(A) Pleural effusion was shown by imaging findings before the patient underwent crizotinib combined with anlotinib treatment in August 2018. (B) Significantly large perihepatic effusion was shown by imaging findings before the patient underwent crizotinib combined with anlotinib treatment in August 2018.
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Subsequent CT scans revealed the presence of malignant pleural and peritoneal effusion ( Figure 1 ;  Supplemental Figure ).
(A) The patient's pleural effusion was significantly reduced after 1 month of treatment compared to pre-treatment. (B) The patient's peritoneal effusion was significantly reduced after 1 month of treatment compared to pre-treatment.
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The treatment resulted in significant symptom relief, and the malignant pleural and peritoneal effusion decreased compared to the CT results on August 21, 2018 ( Figure 2 ).