PMC9489902_01
Myocardial degeneration and necrosis; myocardial interstitium is mainly infiltrated by lymphocytes and monocytes (arrows).
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Histological examination revealed that the left anterior descending coronary artery and the right coronary artery had mild atherosclerotic stenosis; the heart showed multi-focal inflammatory infiltration, mainly lymphocytes and monocytes associated myocyte degeneration and necrosis of both left and right ventricular walls (Figure 1). The lungs showed edema with local inflammatory cell infiltration (Supplementary Figure 1).
Immunohistochemical staining for protein expression of spike receptor binding domain (RBD) in heart sections. (A) Representative images of immunohistochemical staining of heart section showed occasional spike RBD positive cardiomyocytes (arrows). (B) Representative images showing spike RBD expression in the infiltrating immune cells in myocardium (arrows). (C) Representative images showing spike RBD expression in the vascular endothelial cells in myocardium (arrows).
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Immunohistochemical staining of heart section showed occasional spike RBD positive cardiomyocytes, infiltrating immune cells and vascular endothelial cells (Figures 2A-C). Intracerebral vascular filling was poor, and the perivascular space was enlarged (Supplementary Figure 2A). The liver showed autolysis (Supplementary Figure 2B).