PMC2249602_01
MRI findings one month before initiation of thalidomide, showing marked enhancement of infundibulum (6 mm) and bilateral optic nerves (6 mm).
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F1
Repeat MRI of the brain (see figure 1) had also progressed, now showing more prominent enhancement and thickening of the optic nerves, bilaterally (up to 6 mm in greatest thickness).
MRI Brain with contrast demonstrating improvement 2 months after initiation of thalidomide.
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F2
After two months of treatment, the patient had radiographic improvement on follow-up MRI scan (see figure 2).
MRI brain with contrast showing near resolution of enhancement, stable on serial MRIs for 2 years.
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F3
Following another 4 to 10 months of thalidomide, there was complete resolution of all abnormal enhancement on MRI, which has been maintained over the past several years (see figure 3).