PMC6360978_01
A 0.5cm papule on the left anterior neck, above a crosssectional
thyroidectomy scar.
abd-94-01-0076-g01.jpg
PMC6360978_01_abd-94-01-0076-g01.jpg
f1
A 55-year-old female presented an erythematous, asymptomatic papule of 0.5cm in diameter on her left anterior neck, just above a midline transverse scar caused by a thyroidectomy. (figure1) Excisional biopsy was performed.
Well demarcated lesion with a trabecular and glandular arrangement.
Hematoxylin and eosin A - superficial portion, x40.
B - deep portion, x100
abd-94-01-0076-g02.jpg
PMC6360978_01_abd-94-01-0076-g02.jpg
f2
The histopathological examination showed a well-demarcated lesion of cells in trabecular and glandular arrangement (Figure 2).
The cells showed enlarged, hyperchromatic nuclei and frequent mitotic
figures, some of them atypical. Hematoxylin and eosin, x400
abd-94-01-0076-g03.jpg
PMC6360978_01_abd-94-01-0076-g03.jpg
f3
The cells displayed enlarged and hyperchromatic nuclei and frequent mitotic figures, including atypical ones (Figure 3).
Occasionally, there was eosinophilic secretion in the lumen. Hematoxylin
and eosin, x400
abd-94-01-0076-g04.jpg
PMC6360978_01_abd-94-01-0076-g04.jpg
f4
Occasionally, there was eosinophilic secretion in the lumen (Figure 4).
Positive immunohistochemistry panel for antithyroglobulin.
Immunoperoxidase, x100. Marker: thyroglobulin; clone: polyclonal
abd-94-01-0076-g05.jpg
PMC6360978_01_abd-94-01-0076-g05.jpg
f5
The tissue was submitted to immunohistochemical analysis which was positive for anti-cytokeratin and anti-thyroglobulin - cytokeratin markers of 40, 48, 50 and 50.6 kDa and AE1/AE3 clones - confirming the diagnosis of a primary thyroid tumor (Figure 5).