PMC5660631_01
(
A
) The clinical picture of the right thigh after 2-months of conservative treatment; (
B
) the lesion of the thigh after surgical biopsy (visible skin sutures) that confirmed the diagnosis; (
C
) the same skin surface after 4 months of chemotherapy.
10-1055-s-0037-1607036-i170335cr-1.jpg
PMC5660631_01_10-1055-s-0037-1607036-i170335cr-1.jpg
FI170335cr-1
Clinically, a large (10 x 5 cm) single, rectangular, flat, stiff infiltration with redness and peeling of the skin was observed ( Fig. 1A ). The patient was transferred to our pediatric surgery department for treatment and surgical biopsy of the lesion ( Fig. 1B ).  During the first weeks of treatment, there was a Pseudomonas aeruginosa infection of the wound after the surgical biopsy which was treated with targeted antibiotic therapy and later underwent surgical debridement with good wound healing ( Fig. 1C ).
Hematoxylin and eosin staining (extension x200). Skin biopsy showing subcutaneous tissue with neoplastic infiltrate. The neoplastic cells range in size and have irregular, hyperchromatic nuclei. The characteristic feature is the rimming of the neoplastic cells surrounding individual fat cells.
10-1055-s-0037-1607036-i170335cr-2.jpg
PMC5660631_01_10-1055-s-0037-1607036-i170335cr-2.jpg
FI170335cr-2
Characteristic rimming of individual fat cells by tumor cells with immunohistochemical staining specific for SPTCL was visualized in our patient's specimen ( Fig. 2 ). 