PMC5925955_01
Chest computed tomography (CT) before lobectomy. It revealed a 72-mm irregularity in the upper-left lobe (A) with typical interstitial pneumonia in the inferior lobes (B).
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Computed tomography (CT) revealed a 72-mm irregularity in the upper-left lobe with typical interstitial pneumonia in the inferior lobes (Fig. 1).
Histopathological findings obtained from left upper lobectomy. An image of a hematoxylin and eosin-stained section showing the tumor diffuse proliferation of pleomorphic tumor cells. (A) (magnification, x100) Immunohistochemical analysis showed positive for cytokeratin AE1/AE3 in the epithelial component (B) (magnification, x100) and vimentin in the stromal component. (C) (magnification, x100).
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Stromal component does not show specific differentiation such as bone, cartilage nor musculus (see Fig. 2).
Head magnetic resonance imaging (MRI) showed a brain tumor on right brain hemisphere.
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Head magnetic resonance imaging showed a brain tumor on right brain hemisphere (Fig. 3).
Histopathological findings obtained from a brain tumor resection. An image of a hematoxylin and eosin-stained section showing. (A) (magnification, x200) Immunohistochemical analysis showed positive for cytokeratin AE1/AE3 in the epithelial component (B) (magnification,x100) and vimentin diffusely . (C) (magnification, x100).
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The tumor was excised, and histopathology revealed that the tumor cells in the brain were similar to those of the left lung (consisting of epithelial and mesenchymal component, and positive for AE1/AE3 and vimentin, respectively) (Fig. 4).
Chest CT after surgery to remove the metastatic tumor from the brain showed new lesions in his right lung and mediastinal lymph nodes (A), and following 2 (B) and 4 (C) cycles of nab-paclitaxel plus carboplatin combination chemotherapy.
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Moreover, chest CT scans detected new lesions in his right lung and mediastinal lymph nodes (Fig. 5 (A)). CBDCA, area under the curve = 6, every 4 weeks. CT scans of the chest after four cycles of this regimen revealed a 47% reduction in the sum of the diameters of the target lesions compared with baseline, indicating a partial response (PR) (Fig. 5(B)). A reduction in the size of each of the target lesions was detected after 4 cycles of this regimen (Fig. 5(C)).