PMC3420420_01
Bone marrow biopsy before treatment with romiplostim showing the absence of reticulin fibrosis (Silver stain, original magnification x 400).
CRIM.HEMATOLOGY2012-318597.001.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.001.jpg
fig1
A bone marrow examination was performed showing mildly hypercellular marrow for age (50-60% cellularity), without fibrosis (Figures 1, 3, 5 and 7).
Bone marrow biopsy after treatment with romiplostim demonstrating marked diffuse reticulin fibrosis (Note coarse reticulin fiber network) (Silver stain, original magnification x 400).
CRIM.HEMATOLOGY2012-318597.002.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.002.jpg
fig2
A repeat bone marrow biopsy was performed showing markedly increased cellularity (90% cellularity), slight dyserythropoiesis, occasional atypical megakaryocytes, and now with a marked diffuse reticulin fibrosis (Figures 2, 4, 6 and 8).
Bone marrow aspirate with normal megakaryocytes (Wright-Giemsa, original magnification x 100).
CRIM.HEMATOLOGY2012-318597.003.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.003.jpg
fig3
A bone marrow examination was performed showing mildly hypercellular marrow for age (50-60% cellularity), without fibrosis (Figures 1, 3, 5 and 7).
Bone marrow aspirate after treatment with romiplostim with hypolobated megakaryocytes (Wright-Giemsa, original magnification x 100).
CRIM.HEMATOLOGY2012-318597.004.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.004.jpg
fig4
A repeat bone marrow biopsy was performed showing markedly increased cellularity (90% cellularity), slight dyserythropoiesis, occasional atypical megakaryocytes, and now with a marked diffuse reticulin fibrosis (Figures 2, 4, 6 and 8).
Bone marrow aspirate with normal erythropoiesis (Wright-Giemsa, original magnification x 100).
CRIM.HEMATOLOGY2012-318597.005.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.005.jpg
fig5
A bone marrow examination was performed showing mildly hypercellular marrow for age (50-60% cellularity), without fibrosis (Figures 1, 3, 5 and 7).
Bone marrow aspirate after treatment with romiplostim with erythrodysplasia (Note binucleation, irregular nuclear contours, and dyssynchronic maturation of the erythroid line) (Wright-Giemsa, original magnification x 1000).
CRIM.HEMATOLOGY2012-318597.006.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.006.jpg
fig6
A repeat bone marrow biopsy was performed showing markedly increased cellularity (90% cellularity), slight dyserythropoiesis, occasional atypical megakaryocytes, and now with a marked diffuse reticulin fibrosis (Figures 2, 4, 6 and 8).
Mildly hypercellular bone marrow for age (50-60% cellularity) (hematoxylin-eosin, original magnification x 100).
CRIM.HEMATOLOGY2012-318597.007.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.007.jpg
fig7
A bone marrow examination was performed showing mildly hypercellular marrow for age (50-60% cellularity), without fibrosis (Figures 1, 3, 5 and 7).
Marked hypercellular bone marrow for age (90% cellularity), with slight dyserythropoiesis (hematoxylin-eosin, original magnification x 40).
CRIM.HEMATOLOGY2012-318597.008.jpg
PMC3420420_01_CRIM.HEMATOLOGY2012-318597.008.jpg
fig8
A repeat bone marrow biopsy was performed showing markedly increased cellularity (90% cellularity), slight dyserythropoiesis, occasional atypical megakaryocytes, and now with a marked diffuse reticulin fibrosis (Figures 2, 4, 6 and 8).