PMC3663384_01
Annular anesthetic plaque with raised margins on the right temporal and frontal region. [Copyright:  2013 Massone et al.]
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Physical examination disclosed an annular plaque of almost 10 x 8 cm in diameter (Figure 1). The supraorbital nerve was thickened and palpable (Figure 1, white arrow).
Multifocal superficial and deep granulomatous dermatitis with epithelioid granulomas (hematoxylin and eosin, original magnification 40x). [Copyright:  2013 Massone et al.]
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Skin biopsy showed a multifocal superficial and deep granulomatous dermatitis with epithelioid granulomas (Figures 2 and 3) with perineural distribution.
Epithelioid granulomas without necrosis (hematoxylin and eosin, original magnification 200x). [Copyright:  2013 Massone et al.]
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Skin biopsy showed a multifocal superficial and deep granulomatous dermatitis with epithelioid granulomas (Figures 2 and 3) with perineural distribution.
The granulomas are focally "touching" the epidermis. Moreover, multinucleated giant cells and slightly intra-granuloma edema are observed (hematoxylin and eosin, original magnification 100x). [Copyright:  2013 Massone et al.]
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The granulomas were also focally "touching" the epidermis (Figure 4).