PMC3636970_01
Ultrasonographic findings. Right thyroid lobe enlargement and numerous microcalcifications can be seen.
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F1
Diffuse enlargement of the right thyroid gland with many small calcifications was detected by ultrasonography (fig. 1).
Cut surface of the right thyroid lobe. An indistinct diffuse lesion with microcalcifications can be seen.
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F2
It was sclerosing and rich in microcalcifications (fig. 2).
DSV-PTC. a Growing papillary tumor with remarkable fibrosis and lymphocytic infiltration can be seen. HE. x100. b Note the numerous psammoma bodies. HE. x400. c Scattered foci of squamous metaplasia can be seen. HE. x400. d Characteristic nuclear features of PTC. Nuclear grooves and intracytoplasmic inclusion body (inset) can be seen. HE. x400.
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F3
On microscopic examination, the tumor showed a papillary growth pattern with distinct fibrosis, severe lymphocyte infiltration (fig. 3a), numerous psammoma bodies (fig. 3b), and squamous metaplasia (fig. 3c); all characteristics of DSV-PTC were frequently seen. In high-power fields, many of the tumor cell nuclei exhibited a ground-glass appearance, frequent grooves, and pseudoinclusions (fig. 3d).
Tumor cells are positive for ER (a), PgR in the nucleus (b), and E-cadherin in the cytoplasm (c). d Dendritic/Langerhans cells are positive for S-100 protein. Immunohistostaining. x400.
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F4
The tumor cell nuclei were positive for ER and PgR (fig. 4a, b), and the cells were positive for epithelial membrane antigen, cytokeratin 7, thyroglobulin, E-cadherin, and beta-catenin. Reduced membranous staining and increased cytoplasmic staining of E-cadherin were notable (fig. 4c). In addition, dendritic/Langerhans cells were positive for S-100 protein (fig. 4d).