PMC8632248_01
Trend of hemoglobin (Hb; dotted black line) and lactate dehydrogenase (LDH; dashed-dotted black line) levels along the patient's clinical journey. ULN, upper limit of normal; HU, hydroxyurea; ASA, acetylsalicylic acid; LMWH, low-molecular weight heparin; ET, essential thrombocythemia; PNH, paroxysmal nocturnal hemoglobinuria. Red drops represent red blood cell transfusions.
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From March 2016, a trend to increased lactate dehydrogenase (LDH) levels was noticed, and from February 2019, a mild macrocytic anemia [hemoglobin (Hb) 10.2 g/dL, mean corpuscular volume (MCV) 103 fL; normal iron and vitamin status] developed ( Figure 1 ).