PMC9289264_01
Post-transplant clinical course. Platelet count, serum creatinine level, urine protein-creatinine ratio, haptoglobin, and complement titers are also shown to illustrate changes in transplant-associated thrombotic microangiopathy disease status. BMT, Bone marrow transplantation; Plt, blood platelet; Cr, creatinine; U-TP/Cre, urine protein-to-creatinine ratio; CH50, 50% hemolytic unit of complement; C5b-9, membrane attack complex; HDF, hemodiafiltration; RCC-LR, red cell concentrates-leukocytes reduced; PC, platelet concentrate; Ca, calcium.
fped-10-908183-g0001.jpg
PMC9289264_01_fped-10-908183-g0001.jpg
F1
Two months later, the patient became transfusion independent (Figure 1).
Pathological findings (optical microscopy). (A,B) Two different glomeruli at 400x of PAS. (C) Glomerulus at 400x of PAM. (D) Kidney tissue at 20x of MASSON. The changes in the basement membrane of the hoof were minimal, mesangial proliferation was partial, and fibrosis was observed in only 10% of the cases. No membranoproliferative glomerulonephritis-like findings were observed in the chronic phase of impaired TMA, and there were only two sclerotic glomeruli (arrow) out of 18. PAS, periodic acid Schiff stain; PAM, periodic acid-methenamine-silver stain; MASSON, masson trichrome stain.
fped-10-908183-g0002.jpg
PMC9289264_01_fped-10-908183-g0002.jpg
F2
There were only two sclerotic glomeruli, out of 18 (Figure 2).