PMC4345234_01
(a) Lower leg ulcer on admission, (b) lower leg ulcer after five days of ganciclovir treatment, (c) H&E staining showing cytoplasmic and nuclear inclusions characteristic of CMV infection, and (d) immunohistochemistry staining for CMV.
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fig1
Pertinent physical exam findings include marked scleral icterus, jaundice, diffuse abdominal tenderness, a nonverbal state, and two symmetric well-circumscribed oval shallow ulcerations on bilateral lower medial legs (Figure 1(a)). Leg ulcerations improved rapidly and significantly (Figure 1(b)). Using this protocol, histopathology showed scattered endothelial cells with eosinophilic cytoplasmic inclusions and a characteristic halo surrounding the nuclear inclusion (Figure 1(c)). Immunohistochemistry was positive for CMV inclusions (Figure 1(d)).