PMC1226150_01
Microscopically, the extracted urinary bladder tissue particles proved to be pieces of papillary transitional cell carcinoma grade II [A) hematoxylin and eosin x 40] and immunohistochemically they expressed cytokeratin 7 [B) cytokeratin 7 x 100].
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F1
The histology of resected specimen was papillary transitional cell carcinoma grade II (Figure 1A). The tumor cells were positive for cytokeratin 7 (Figure 1B) and negative for cytokeratin 20.
Histologically, in most of the prostate tissue fragments were recognized areas of, partially mucinous, adenocarcinoma of the prostate, grade II-III (A. hematoxylin and eosin x 40, B: hematoxylin and eosin x 100). The tumor cells were strongly positive for PSA (C: PSA x 40).
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F2
Seven out of the 10 examined slides revealed foci of partially mucinous (Figure 2A) adenocarcinoma of the prostate (the greatest measured focus was 8.5 mm in maximum diameter), Gleason grade II-III and Gleason score 5 (Figure 2A, B). Immunohistochemical study was performed and showed strong positivity for Prostate Specific antigen (PSA) (Figure 2C) whereas; no expression of carcinoembryonic antigen (CEA) was detected in tumor cells.
The bronchial mucosa showed extensive invasion from small blue round cells (A: hematoxylin and eosin x 100) that were positive for the neuroendocrine marker CD56 (B: x 200) and pan-cytokeratin (C: x 200).
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F3
Histology of the bronchial mucosal sample showed infiltration of lamina propria by malignant cells (Figure 3A). CD56 (+) (Figure 3B), Pan-Cytokeratin (paranuclear dot stain positivity) (Figure 3C) and Leukocyte Common Antigen negative. Combining the morphological and the immunohistochemical results, we concluded that the patient was suffering from small cell lung carcinoma (SCLC).