PMC4161525_01
Findings in a 48-year-old Japanese man with oculocutaneous albinism. His best-corrected visual acuity was 2/100 with -14.0 diopters in the right eye.. Notes: (A) External photograph of the right eye showing white cilia and a depigmented iris. (B, C) Fundus photographs at initial examination showing diffuse depigmentation. The right eye had a foveal hemorrhage (B). (D, E) Fluorescein angiographic images at the initial visit showing relative hypofluorescent retinal and choroidal vessels because of the lack of melanin pigment in the retinal pigment epithelium. The right eye has an area of hypofluorescence corresponding to the foveal hemorrhage (D). (F) Indocyanine green angiographic image of the right eye at the initial visit does not show any findings suggestive of choroidal neovascularization. (G) Optical coherence tomographic image corresponds to the arrow in Figure (D). A spectral-domain optical coherence tomographic image of the right eye at the initial visit shows an absence of the foveal pit, and the presence of a subretinal hyperreflective lesion corresponding to the foveal hemorrhage.
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Our examination showed that he had depigmented skin, white hair, white eyebrows, and white cilia (Figure 1A). Ophthalmoscopy showed diffuse depigmentation in both eyes (Figure 1B and C). Fluorescein angiography (FA) showed relatively hypofluorescent retinal and choroidal vessels because of the lack of a blocking effect by pigments in the retinal pigment epithelium (Figure 1D and E). FA also showed an area of hypofluorescence in the right fovea that corresponded with the foveal hemorrhage (Figure 1D). FA and indocyanine green angiography (IA, Figure 1F) did not show any evidence of choroidal neovascularization (CNV) in either eye. However, the blurred optical coherence tomographic images showed an absence of the foveal pit in both eyes and the presence of a subretinal hyperreflective lesion corresponding to the foveal hemorrhage in the right eye (Figure 1G).
Three months after onset. The patient's best-corrected visual acuity has not improved.. Notes: (A) Fundus photograph of the right eye showing that the foveal hemorrhage has regressed. (B) Spectral-domain optical coherence tomographic image of the right eye showing an absence of a subretinal hyperreflective lesion corresponding to the foveal hemorrhage.
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The foveal hemorrhage in the right eye spontaneously regressed and finally resolved at 3 months after onset (Figure 2).