PMC9206517_01
A red-to-violet subcutaneous nodule sized in the diameter of 2 cm on the right volar wrist.
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A 76-year-old Han Chinese previously healthy woman present to the clinic with an indurated, nontender, scarlet red, dome-shaped nodule on her right volar wrist (Figure 1).
Hematoxylin-eosin stain shows large nodular collections crowded basaloid cells in the dermis.
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On the standard hematoxylin-eosin stain, a dermal proliferation was noticed with nests of small blue basaloid cells and a "salt-and-pepper" chromatin pattern with scant cytoplasm and frequent mitotic nucleus (Figures 2 and 3).
High-power magnification shows typical nuclear features with round nuclei with granular chromatin and scant cytoplasm. Scattered mitotic figures are present.
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On the standard hematoxylin-eosin stain, a dermal proliferation was noticed with nests of small blue basaloid cells and a "salt-and-pepper" chromatin pattern with scant cytoplasm and frequent mitotic nucleus (Figures 2 and 3).
Cytokeratin-20 immunohistochemical staining shows a paranuclear dot pattern (original magnification: X200).
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Cytokeratin-20 (CK20) immunohistochemical stain illustrates a typical paranuclear dot pattern (Figure 4).