PMC5012812_01
Abdominal and pelvic computed tomography scan showed the presence of a large tissue process at the upper pole of the right kidney measuring 8 cm of diameter, demonstrating heterogeneous contrast enhancement
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Several small lymphadenopathy in the right hilar area (Figure 1, Figure 2, Figure 3).
Abdominal and pelvic computed tomography scan showed that the process extends over the hilar area with invasion of the right renal vein, while the lower vena cava is permeable
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Several small lymphadenopathy in the right hilar area (Figure 1, Figure 2, Figure 3).
Abdominal Computed tomography scan showed Several small lymphadenopathy in the right hilar area
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Several small lymphadenopathy in the right hilar area (Figure 1, Figure 2, Figure 3).
High-power magnification demonstrating histiocytic proliferation with intracytoplasmic lymphocytes (emperipolesis, arrows), Hematoxylin-eosin stain, original magnification x40
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The final histological examination of the renal mass and regional lymph node showed "emperipolesis", which is characterized by intact inflammatory cells in the cytoplasm of large histiocytes (Figure 4).
High-power magnification with cytoplasmic immunostaining of histiocytic marker (CD68) highlighting proliferating cells (CD68 stain, original magnification x40)
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Histiocytes were positive for CD-68 and negative for CD10, anti CKE1/AE3, antiCK8/18, anti CK19, antidesmine, antiHcaldesmone, CD56, anti synaptophysine, antivimentine and antiMelanA (Figure 5).