PMC4118727_01
Gross-grey white mass.
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figure1
The cut surface was grey-white solid homogeneous [Figure 1].
M/E showing squamous and spindle cell component (H & E Stain; 10x).
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figure2
Microscopic examination revealed a tumour composed of proliferating atypical bipolar spindle cells and small nests of squamous epithelial cells [Figure 2].
M/E showing spindle cells arranged in fascicles (H & E Stain; 10x).
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figure3
Malignant spindle cells, arranged in fascicles [Figures 3 and 4], formed the main bulk of the tumour.
M/E showing spindle cell component (H & E Stain; 40x).
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figure4
Malignant spindle cells, arranged in fascicles [Figures 3 and 4], formed the main bulk of the tumour.
M/E showing epithelial pearl (H & E Stain; 10x).
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figure5
At a few foci, small nests of malignant squamous epithelial cells and epithelial pearls were seen [Figure 5].
IHC showing spindle cells strongly positive for vimentin (10x).
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figure6
On immunohistochemistry, vimentin was strongly positive in the spindle cell component [Figure 6] and negative in the epithelial component.
IHC showing spindle cells focal positivity for cytokeratin (10x).
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figure7
Cytokeratin was focally positive in spindle cell component [Figure 7] and strongly positive in the epithelial component [Figure 8].
IHC showing squamous cells positive for cytokeratin (10x).
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figure8
Cytokeratin was focally positive in spindle cell component [Figure 7] and strongly positive in the epithelial component [Figure 8].