PMC3970243_01
Histologic appearance of the clear cell adenocarcinoma of the colon. (a) H&E slide demonstrates rare variant of colonic adenocarcinoma with clear cell features. It shows gland-forming invasive tissue composed of columnar cells with unusually clear cytoplasm, prominent nucleolus, and central necrotic debris (400x). (b) Immunohistochemistry shows a strongly CDX2 positive staining of the malignant tissue (40x).
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fig1
After the initial Hematoxylin and Eosin staining was performed, the clear cell variant was considered (Figure 1(a)). Subsequently, immunohistochemical stains, which were positive for cytokeratin (CK) 20, CK10, CDX2, and villin, combined with negative CK7, RCC, vimentin, and CD31 (Figure 1(b)), confirmed the clear cell subtype.