PMC4433214_01
Multiple alignments of non-synonymous heterogeneous variants in IRS1 cosegregated with disease in Family A.. The co-segregated variant (1780 C > G transition) in Family A. In this panel, the top graph displays the pedigree structure of Chinese family; the left graph in the middle displays sequencing result of mutated variant; the right graph in the middle displays nucleic acid sequences alignment in multiple species (UCSC Genome Browser); the bottom graph displays amino acid sequences alignment in multiple species (Clustal W).
pone.0126348.g001.jpg
PMC4433214_01_pone.0126348.g001.jpg
pone.0126348.g001
There were 8 affected individuals (male: female = 5:3), 13 genealogical and 5 non-genealogical individuals in the family (Fig 1). The corresponding amino acid was conserved in multiple species as estimated by Clustal W (Fig 1).