PMC8579590_01
Hand involvement in herpes simplex (a) Crusted verrucous plaques on presentation. (b) Complete resolution, 2 weeks after tablet acyclovir 400 mg, TID. (c) Two months later; #fresh vesicle, *contracture upon healing
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F1
A 35-year-old femalepresented with widespread painful crusted skin lesions over both palms and digits [Figure 1]. One month later, she presented again with vesicles over the palms and with genital ulcers, and contractures from the previous episode were evident [Figure 1].
Genital involvement in herpes simplex (a) Ulcer covered with creamy discharge. (b) Healing following treatment with tablet acyclovir 400 mg, TID
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F2
Further, genital examination revealed numerous painful genital ulcers over the labia majora, labia minora, and inner aspect of the thigh covered with a pale creamy discharge [Figure 2].
Histopathology picture showing ballooning degeneration, with some being multinucleated. Mononuclear infiltrate is seen in the upper dermis
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F3
Dense mononuclear infiltrate was present in the upper dermis [Figure 3].