PMC9834148_01
Axial IV contrast-enhanced CT image through the abdomen (A) retroperitoneal mass, mesenteric mass, and splenomegaly, prior to commencing ibrutinib therapy (B) regression of lymphomatous masses but massive splenomegaly, after 7 months of ibrutinib therapy when presenting with lactic acidosis
CCR3-11-e6838-g004.jpg
PMC9834148_01_CCR3-11-e6838-g004.jpg
ccr36838-fig-0001
Computed tomography (CT) revealed a large retroperitoneal mass which extended into a further mesenteric mass (Figure 1). CT showed complete regression of the lymphomatous masses, no evidence of lymphadenopathy, but massive splenomegaly (Figure 1).
Bone marrow findings at relapse, including morphology and flow cytometry of bone marrow aspirate and histopathological features of bone marrow trephine.
CCR3-11-e6838-g001.jpg
PMC9834148_01_CCR3-11-e6838-g001.jpg
ccr36838-fig-0002
Bone marrow biopsy showed almost complete replacement of marrow with the known mantle cell lymphoma, with no evidence of hemophagocytic lymphohistiocytosis (Figure 2).