PMC6691054_01
MRI of the patient after antifungal medication for 2 weeks. (A,B) FLAIR images showed hyperintense signals in the bilateral lateral ventricle white matter and bilateral basal ganglia. Enhanced T1 showed leptomeningeal enhancement in parts of the cerebral hemisphere and cerebellar hemisphere (not shown).
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F1
Repeated brain MRI scans revealed new abnormal signal in the white matter of the bilateral ventricles and the basal ganglia areas (Figures 1A, B, 3A,B).
MRI of the patient after antifungal medication for 8 weeks. (A-C) FLAIR image showed multifocal lesions involving the cerebellar vermis, cerebellar hemispheres, bilateral basal ganglia, and the bilateral cerebral hemisphere. Images also showed large areas of edema and midline shift. (D) ADC and DWI images (not shown) showed hyperintense signals, and did not show evidence of restricted diffusion. (E-H) Enhanced T1 showed patchy enhancement in the bilateral basal ganglia, the cerebellar vermis, and the cerebellar hemisphere, in addition to leptomeningeal enhancement in the bilateral cerebral hemispheres.
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F2
Repeated brain MRIs revealed significant lesions: a large, confluent area of FLAIR hyperintensity in the bilateral basal ganglia, and the white matter of the bilateral cerebral hemispheres, vermis of cerebellar, as well as the cerebellar hemisphere (Figures 2A-C, 3C,D). Enhanced T1 showed contrast enhancement in the bilateral basal ganglia, cerebellar vermis, cerebellar hemispheres (Figures 2D-H), not to mention bilateral leptomeningeal enhancement of the cerebral hemispheres.
T1 images of the brain after antifungal medication for 2 and 8 weeks. (A,B) T1 images of the patient after antifungal medication for 2 weeks. (C,D) T1 images of the patient after antifungal medication for 8 weeks.
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F3
Repeated brain MRI scans revealed new abnormal signal in the white matter of the bilateral ventricles and the basal ganglia areas (Figures 1A, B, 3A,B). Repeated brain MRIs revealed significant lesions: a large, confluent area of FLAIR hyperintensity in the bilateral basal ganglia, and the white matter of the bilateral cerebral hemispheres, vermis of cerebellar, as well as the cerebellar hemisphere (Figures 2A-C, 3C,D).