PMC6393871_01
Baseline CT scan shows the normal size and appearance of the spleen before using granulocyte colony-stimulating factor (G-CSF).
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Computed tomography (CT) scan ruled out infectious focus and showed hepatosplenomegaly with multiple splenic hypodensities and minimal perisplenic fluid which did not appear in the baseline scan (Figures 1 and 2).
Hepatosplenomegaly with multiple splenic hypodensities consistent with splenic infarction (arrow) after using G-CSF.
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Computed tomography (CT) scan ruled out infectious focus and showed hepatosplenomegaly with multiple splenic hypodensities and minimal perisplenic fluid which did not appear in the baseline scan (Figures 1 and 2).
Splenic tissue with focal hemorrhagic infarction necrosis and predominantly neutrophil polymorphs. (a-d) H/E-stained section.
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Infectious disease team advised for a splenic biopsy which showed splenic infarction only with no evidence of bacterial, fungal, viral, or malignant involvement (Figure 3).
Follow-up CT scan shows hepatosplenomegaly with interval improvement regarding the splenic infarction.
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General surgery team was consulted and did not recommend any surgical intervention since the follow-up CT scan turned out negative for splenic abscesses with interval improvement in the previous splenic wedge-shaped hypodensities (Figure 4).