PMC8655799_01
(A, B) Undifferentiated carcinoma (A, hematoxylin and eosin stain, 10 x objective) with diffuse involvement by pleomorphic mononuclear cells, which were positive for cytokeratins AE1/AE3 (B, 10 x objective). (C, D) Malignant mononuclear epithelial cells (C, hematoxylin and eosin stain, 20 x objective) were accompanied by numerous non-neoplastic multinucleated histiocytic cells that were positive for CD68 (D, 20 x objective). (E, F) Well-differentiated ductal adenocarcinoma component (E, hematoxylin and eosin stain, 10 x objective) highlighted by cytokeratin AE1/AE3 immunohistochemical stain (F, 10 x objective).
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Histopathological evaluation of the tumor (Fig. 1) revealed a mostly undifferentiated pancreatic carcinoma composed of malignant pleomorphic mononuclear epithelial cells (A) accompanied by numerous non-neoplastic multinucleated giant cells (C).