PMC6346815_01
Magnetic resonance imaging clearly shows the right frontal lobe mass extending to the corpus callosum
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PMC6346815_01_954_Fig1.jpg
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The mass measured 5.7 cm by 3.8 cm (Fig. 1).
Histopathology: (1) H&E stain reveals the tumour with necrosis; (2) GFAP immunostaining is positive for tumour cells; a blood vessel with negative staining shows microvascular proliferation; (3) MIB-1 immunostaining of numerous tumour cells. Molecular information: MIB proliferation index 20%. IDH1 R123H (IHC): negative. IDH1 (NGS): negative; EGFRvIII mutation: negative; MGMT promoter methylation: negative
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PMC6346815_01_954_Fig2.jpg
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Frozen sections and biopsy slides (Fig. 2) showed an infiltrating astrocytic tumour with necrosis, microvascular proliferation, and brisk mitotic activity.