PMC9283775_01
Skin histopathology (A) shows that the epidermis is separated from the dermis with blisters in the epidermis (10x). Immunofluorescence staining (B) reveals linear C3 and IgG deposits along the basement membrane. Patient timeline (C) demonstrates the therapeutic schedule and disease status.
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F1
Skin histopathology (Figure 1A) showed that the epidermis was separated from the dermis by blisters in the epidermis. The patient's treatment timeline is shown in Figure 1C.
Stamp therapy. (A-C) Stamp gauze soaked with sesame oil mixed with berberine. (D) Stamp gauze is affixed thoroughly to the broken skin of the patient. (E) Bandage is wrapped around the periphery to prevent the gauze from falling.
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F2
Berberine is primarily derived from Coptis chinensis Franch and is typically administered in clinical practice as berberine hydrochloride tablets (Figures 2A,C). Berberine was ground into powder and blended with sesame oil (50 mg/mL) (Figure 2B). Small gauze was immersed in the mixture and was applied one by one to the cutaneous wound in the form of stamps (Figure 2D). Finally, a bandage was wrapped around the outside to prevent the small gauze from falling off (Figure 2E).
Clinical manifestations of patients with pemphigus. (A,B) Before treatment, (C,D) 2 weeks after treatment, (E,F) during follow-up.
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F3
Two weeks later, the patient's periocular and trunk skin lesions were significantly improved, comprising only 2% of the residual surface area of the erosive surface (Figures 3A-D). After hospital discharge, the patient completely recovered from BP and had a great quality of life during follow-up (Figures 3E,F).