PMC7658490_01
Chest X-ray demonstrating reticulonodular infiltration and cysts.
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A CXR at this time showed a bilateral reticulomicronodular infiltration with associated cysts throughout all zones (Fig. 1).
CT Thorax showing an extensive nodulocystic pattern bilaterally in the transverse view (a) and throughout all lobes in the sagittal and coronal views (b,c).
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A CT Thorax revealed progression with extensive multifocal cystic lesions and nodules throughout all lobes (Fig. 2a-c).
- Histopathology slides of specimens from wedge resection of right middle and lower lobes (a-d). a,b - H&E Stain (x20 magnification) nodules with cystic change that appear centred in and destructive of the small airways, honeycombing with fibrosis. c - H&E Stain (x400 magnification) Mostly pale and some dustily pigmented histiocytes with characteristic reniform nuclei, abundant pigmented alveolar macrophages and scattered eosinophils. d - CD1a Stain (x200 magnification) Histiocytes demonstrating positive CD1a staining.
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He was further investigated with a thorascopic wedge resection which revealed histiocytic nodules that positively stained for CD1a with abundant pigmented alveolar macrophages and scattered inconspicuous eosinophils (Fig. 3a-d).