PMC5271674_01
a) microcystic lesions; b) c) and d) multiple smooth interlobular and intralobular thickening with centrilobular and subpleural micronodules.
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A chest HRCT showed microcystic lesions, bilateral smooth interlobular and intralobular thickening with centrilobular and subpleuralmicronodules, (Fig. 1).
a) microcystic lesions; b) and c) multiple pseudonodular consolidations; d) pleural thickening.
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The HRCT showed multiple bilateral pseudonodular consolidations, subpleural, perilobular and pleural thickening and microcystic lesions (Fig. 2), with no response to steroid and antimicrobial therapy.
a) fibrous pleural and subpleural thickening, along the interlobular septal; b) diffuse infiltrated of histiocytes with abundant cytoplasm and vescicolous nuclei, accompanied by lymphocytes and plasma cells with abundant fibrosis with no granulomas; c) positivity for CD68; d) positivity for S100.
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The proliferation was associated with a fibrotic stroma and few lymphocites Immunohistochemical analyses were positive for CD68, S100 (focal) and negative for CD1a markers (Fig. 3). This picture was compatible with ECD.
Legend:18FDG- PET- CT showing the prevertebral tissue.
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Six months later, a 18FDG- PET- CT was carried out: a symmetric diametaphyseal uptake in the long bones of the legs was noted along with a pathological uptake in the prevertebral space, beyond the already known pulmonary lesions (Fig. 4).