PMC3806683_01
Findings in a 39-year-old woman with AZOOR in the right (a-e) and left (f-j) eyes. Fundus photographs show no specific abnormalities (a, f). OCT horizontal scan (b) and high-magnification OCT findings (c) show an absent photoreceptor IS/OS line and the COST line within AZOOR lesions (in the macula area) in the right eye. In the left eye, the IS/OS line and the COST line were detected (g, h). mfERG response arrays (d, i) and 3-dimensional plots (e, j) showed reduced responses in the right eye. Arrowheads indicate the IS/OS line. Arrows indicate the COST line.
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F1
No inflammatory cells were observed in the anterior segment or vitreous of either eye, and there were no specific abnormal findings during a fundus examination (fig. 1a, f). OCT (RS-3000; Nidek, Japan) showed that while there was attenuation of the IS/OS line throughout the entire region of her right eye and the COST line (fig. 1b, c), no specific abnormalities were detected in her left eye (fig. 1g, h). mfERG (LE-4100; Tomey, Japan) findings showed markedly decreased amplitudes in the right eye (fig. 1d, e) and no abnormalities in the left eye (fig. 1i, j). The patient was followed without any treatment.
Changes in high-magnification OCT findings in a 39-year-old woman with AZOOR in the right eye (a-c). At the initial visit, OCT showed attenuation of the IS/OS line and the COST line (a). After 2 months, OCT showed a partial restoration of the IS/OS line (b); however, the COST line was still absent. At 4 months, reappearance of the IS/OS line was detected by OCT (c); however, the COST line was still absent. Arrowheads indicate the IS/OS line.
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F2
BCVA improved to 0.9 in the right eye and OCT revealed there was no recovery of the IS/OS at the foveal area at 1 month after the initial visit (fig. 2a). After 2 months, BCVA improved to 1.2 in the right eye and OCT showed a partial restoration of the IS/OS line (fig. 2b); however, the COST line was still absent, and she had no change in mfERG findings. At 4 months, reappearance of the IS/OS line was detected by OCT (fig. 2c).