PMC4434161_01
Preoperative sagittal MRI with IV contrast showing enhancing mass involving the anterior body of the corpus callosum.
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An MRI demonstrated a well-circumscribed heterogeneously enhancing mass involving the anterior body of the corpus callosum and extending superiorly to the falx cerebri, measuring 3.6 x 4.1 cm (Fig. 1).
(A) Microscopic low-power view showing brain parenchyma infiltrated by carcinoma and extensive areas of necrosis (H&E, x 40). (B) Medium-power view showing tumor forming glandular structures and a pseudopapillary arrangement of the tumor cells (H&E, x 200). (C) High-power view showing highly pleomorphic tumor cells and one atypical tetra-polar mitotic figure (blue arrow, H&E, x 400). (D) Tumor cells with positive cytokeratin-7 immunohistochemical stain (CK7, x 200).
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Histology revealed cerebral metastasis from serous carcinoma with immunohistochemistry profile (CK7 +, CK8/18 +, CK20 -, CDX2 -, BRST2 -, TTF1 -) consistent with primary endometrial carcinoma (Fig. 2).