PMC5660109_01
Initial presentation of the patient: (A) the right nipple lesion. Initial presentation of the patient: (B) macroscopic right nipple lesion, erosion, and redness of the nipple were noted.
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F1
The examination revealed an eczematous aspect of the right nipple suggesting Paget's disease (Figures 1A,B).
Mammography showed a dense ovoid opacity of 14 mm with irregular suspicious micro calcifications.
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F2
Mammography showed a dense ovoid opacity of 14 mm with irregular suspicious micro calcifications (Figure 2).
Ultrasound right nipple: suspect galactophoric dilatation of the right supero-external quadrant.
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F3
A suspect galactophoric dilatation of the right supero-external quadrant was seen by ultrasound (Figure 3).
(A,B) Images coupe de biopsie. Biopsy concluded to a ductal multicentric carcinoma in situ, nuclear grade 2-3, HER2 (+), ER, and PRG (-), classification as B5a. Microscopic examination of the specimen using H&E staining. (A) The epidermis of the nipple infiltrated by large Paget's cells with pale abundant cytoplasm (magnification, x100). (B) Single groups of Paget's cells with vesicular nuclei and prominent nucleoli (magnification, x400).
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F4
B5a (Figures 4A,B). Breast magnetic resonance imaging (MRI) revealed several multicentric tumoral lesions of the right breast with extension to the nipple-areola complex (Figure 5).
Breast magnetic resonance imaging revealed several multicentric tumoral lesions of the right breast with extension to the nipple-areola complex.
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F5
B5a (Figures 4A,B). Breast magnetic resonance imaging (MRI) revealed several multicentric tumoral lesions of the right breast with extension to the nipple-areola complex (Figure 5).