PMC5824513_01
A painful expansion in the left mandibular region and marked facial asymmetry
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F1
A 32-year-old female patient was referred to a dentist for evaluation of a painful expansion in her mandible [Figure 1].
Intraoral examination showed a diffuse swelling in the posterior area of left mandible with erythematous and ulcerated overlying mucosa
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F2
The overlying mucosa was erythematous, ulcerated and necrotic [Figure 2].
Panoramic radiograph of the primary lesion showed a radiolucent lesion with ill-defined borders extending from the left mandibular second premolar to the second molar
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F3
The panoramic radiograph showed a radiolucent lesion with ill-defined borders extending from the second premolar to second molar [Figure 3].
Histopathologic feature in a low magnification illustrates the nature of the tissue as a mixed odontogenic lesion
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F4
Careful evaluation of slide number 1 showed scattered benign ameloblastic islands and dental papilla-like stroma with tumoral giant cells [Figures 4 and 5].
Histopathologic section showed scattered odontogenic islands and pleomorphic giant stromal cells in a malignant dental papilla-like connective tissue (x100)
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F5
Careful evaluation of slide number 1 showed scattered benign ameloblastic islands and dental papilla-like stroma with tumoral giant cells [Figures 4 and 5].
Hyalinization was seen around some odontogenic islands (x100)
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F6
Hyalinization was seen around these benign islands [Figure 6].
Some amount of dentinoid material was found near the odontogenic epithelial nests (x100)
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F7
Dentinoid material was also found near some odontogenic epithelial nests [Figure 7].
Some eosinophilic material was found in the malignant counterpart. The histopathologic feature in these areas was very similar to fibroblastic osteosarcoma (x100)
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F8
Some eosinophilic materials, most likely dysplastic dentin, were also found in this malignant counterpart [Figures 8 and 9].
The eosinophilic material in sarcomatous area was osteoid like (x400)
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F9
Some eosinophilic materials, most likely dysplastic dentin, were also found in this malignant counterpart [Figures 8 and 9].