PMC5803942_01
Lax nasolabial folds
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F1
Cutaneous examination revealed loose hanging ear lobes, blepharochalasis, lax nasolabial folds, and increased folds over the neck, axilla, and trunk [Figures 1-3].
Increased cutaneous folds over the neck, chest, and axillary region
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F2
Cutaneous examination revealed loose hanging ear lobes, blepharochalasis, lax nasolabial folds, and increased folds over the neck, axilla, and trunk [Figures 1-3].
Increased cutaneous folds over the back
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F3
Cutaneous examination revealed loose hanging ear lobes, blepharochalasis, lax nasolabial folds, and increased folds over the neck, axilla, and trunk [Figures 1-3].
Normal thickness of epidermis with no evident dermal inflammatory infiltrate and normal collagen bundles. Elastin fiber changes are not well appreciated on H and E staining. H and E, x10
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F4
Skin biopsy showed markedly reduced elastic fibers [Figures 4 and 5].
Marked reduction in elastic fibers in the superficial and deep reticular dermis with mild reduction of elastic fibers in the papillary dermis. Orcein stain, x10
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F5
Skin biopsy showed markedly reduced elastic fibers [Figures 4 and 5].