PMC5215263_01
MRI of the abdomen with EV contrast. An expansive formation in segment VIII and spreading towards segment IVA. It is heterogeneously T2-hyperintense (A) and in diffusion sequences (B), with marked hypointensity in the apparent diffusion coefficient (ADC) maps (D), as manifestation of increased cellularity. An endovenous contrast injection faintly highlighted a peripheral capsule in the later cuts (C). Ref: MRI: magnetic resonance imaging. EV: endovenous.
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An endovenous contrast injection faintly highlighted a peripheral capsule in later cuts (Figure 1).
Macroscopic examination of hepatic segments IV, V, and VIII. Presence of a solid, whitish tumour with central cystic degeneration measuring 9 x 9 cm.
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This was found to be surrounded by a thin capsule (Figure 2).
Hepatic metastatic thymoma sub-type B1, stained with haematoxylin and eosin. A) The lesion is organotypic, with a scarcity of epithelial cells and an abundance of small lymphocytes with an expansive growth pattern. B) Epithelial and lymphocytic component of the thymoma. Original magnification 100 x (A); 400 x (B).
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The lesion presented an expansive border which delineated it from the adjacent hepatic parenchyma, which itself showed no significant changes (Figures 3A and 3B).
Immunohistochemical techniques. Positivity with CD3 (A), CD5 (B), CD99 (C) and TdT (D) in the lymphocytic component of the thymoma. (E and F) Positivity with pankeratin (AE1AE3) in the epithelial component of the tumour.
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The lymphoid population showed intense positivity for CD3, CD5, CD8, and CD99 (Figures 4A to 4D) and weak positivity for CD4 and CD43. The cytokeratin cocktail showed positivity in the tumour's epithelial component (Figures 4E and 4F).