PMC2931391_01
(a) Periportal triad inflammation (b) cholestasis and hepatocyte necrosis (zone 3) iron liver 321 ug/g dry wt (400-2200), hepatic iron index 0.1 umoL/g/yr (<1.0).
CRM2010-262706.001.jpg
PMC2931391_01_CRM2010-262706.001.jpg
fig1
Liver histopathology revealed mild periportal and intraparenchymal chronic inflammation, including plasma cells, with focal areas of acute inflammation and patchy hepatocyte necrosis with moderately increased iron storage (Iron liver dry weight 321 ug/g (400-2200) hepatic iron index 0.1 umoL/g/yr (<1.0)) (Figure 1).
Followup labs at 6 weeks.
CRM2010-262706.002.jpg
PMC2931391_01_CRM2010-262706.002.jpg
fig2
Repeat liver-associated enzymes had nearly normalized (ALT-135 U/L and total bilirubin-1.4 mg/uL) and iron studies showed a % iron saturation of 52% and serum ferritin of 196 ng/ml (Figure 2).