PMC8671743_01
Imaging and pathology of the tumor. Representative (A) sagittal (B) coronal and (C) axial slices of a T1-weighted post-contrast MRI, obtained prior to surgery, showed a pituitary mass, measuring 1.6x1.5x2.6 cm. Final pathology of the resected tumor revealed a low grade neoplasm of polygonal cells with mild nuclear pleomorphism and granular cytoplasm on routine hematoxylin and eosin staining at (D) 200x and (E) 400x magnification. (F) Immunohistochemical stains revealed strong positivity for TTF-1 (magnification 400x).
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A 77 year-old female with a recent diagnosis of ductal carcinoma of the breast in-situ with subsequent radiation and no radiographic evidence of recurrence was incidentally found to have a pituitary mass, measuring 1.6x1.5x2.6 cm on magnetic resonance imaging (MRI) of the brain, performed for a work-up of worsening hearing loss ( Figures 1A-C ). Final pathology revealed a low grade neoplasm composed of polygonal cells with discrete cell borders, mild nuclear pleomorphism, and ample granular to foamy cytoplasm ( Figures 1D, E ). TTF-1 ( Figure 1F ) with focal positivity for CD68.