PMC4752368_01
Metaplastic mammary carcinoma with osseous differentiation (Hematoxylin and Eosin 10x)
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FIG1
Lung biopsy confirmed high-grade malignancy similar to her initial diagnosis consistent with metastatic MpBC (Figure 1).
Representative picture of lung lesion at first restaging scan
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FIG2
Partial response was achieved on the first re-staging scan (Figure 2).
Levels of alkaline phosphatase (IU/L) at baseline and during the course of therapy. Levels corresponded to her radiological response, with initial partial response followed by stable disease
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FIG3
The patient's alkaline phosphatase levels corresponded to the disease response, leading us to believe it was most likely produced by the cancer cells, as there was no evidence of bone invasion (Figure 3).