PMC9345134_01
Tumor aggregates without fibrovascular core surrounded by large empty spaces and separated by thin septa (HP: H&E stain; x5).
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F2
Multiple sections examined from mass revealed an infiltrating tumor composed of small hollow and morula-like clusters of malignant epithelial cells surrounded by distinctly clear space and separated by thin fibrous septa [Figure 2].
Tumor cells in nests and tubules with central lumina displaying reverse polarity and separated by thin fibrous septa. The cells reveal nuclear pleomorphism and coarse chromatin with inconspicuous nucleoli (HP: H&E stain; x40).
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F3
The tumor cells displayed reverse polarity or inside out phenomenon characteristic feature of IMPC seen on histology only [Figure 3].
PMC9345134_02