PMC3897039_01
Nested appearance of tumor cells with overlying bladder mucosa (x400)
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F1
Microscopy revealed a polyp covered by unremarkable epithelium [Figures 1 and 2].
Tumor nests with atypical stromal cells in the background (x00)
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F2
Microscopy revealed a polyp covered by unremarkable epithelium [Figures 1 and 2].
CKAE1AE3 highlighting the nests of tumor cells. Atypical stromal cells are negative. (x400)
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F3
The hyalinized vascular stroma was interspersed with many multinucleated bizarre stromal cells [Figure 3].
p53 positivity in tumor nests (x400)
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F4
Immunohistochemisty showed the cells strongly positive for pankeratin (CK AE1/AE3) [Figure 4] and high molecular weight keratin (34BE12), which confirmed their epithelial nature.
34Be12 positive in tumor nests (x400)
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F5
The cells were also positive for p53 expression [Figure 5] and ki 67 index was high (50% approx.), predicting an aggressive course of the tumor.