PMC2840780_01
Cytogenetic result of unstimulated bone marrow samples showing 47,XX, +4, t(8;21) in all metaphase plates
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Karyotyping results revealed trisomy of 4 with t(8;21) in all metaphase plates in 15 metaphases [Figure 1].
(A) A metaphase cell following FISH with LSI AML-ETO (Abbott Molecular, USA). (B) Whole chromosome paint probe 4 with spectrum Orange (Abbott Molecular, USA)
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The interphase and metaphase FISH results were one green, one orange, and two green-orange or yellow fusion signals indicating AML-ETO fusion positive sample [Figure 2A]. The whole chromosome paint FISH confirmed trisomy of chromosome 4 with no other cryptic rearrangements [Figure 2B].