PMC8374467_01
Melanoma in situ, right ear (case 1). Single atypical intraepidermal melanocytes are seen in an irregular pattern along the dermoepidermal junction (hematoxylin-eosin, original magnification x100).
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F1
In January of 2007, after 35 months of voriconazole therapy, biopsy specimens taken from a 5-mm erythematous and brown macule on the right helix revealed a compound melanocytic neoplasm with evidence of regression; histopathologic findings from a subsequent reexcision demonstrated residual melanoma in situ (Figure 1).
Phototoxic effects and accelerated photoaging associated with chronic voriconazole therapy. Erythema, dermatoheliosis, and lentigines of the central chest (A), forearm (B), and dorsal surfaces of the hands (C) in a 39-year-old woman (case 1).
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F2
Innumerable tan pigmented macules were seen on the face, anterior chest, upper back, and extremities (Figure 2).
PMC8374467_02
Melanoma in situ, left forearm (case 2). A, Melanocytes are arranged in nests and singly along the dermoepidermal junction. The melanocytes are cytologically atypical and display pagetoid upward extension (hematoxylin-eosin, original magnification x100). B, MART-1 stain (melanoma antigen recognized by T cells) highlighting pagetoid spread of cytologically atypical melanocytes (original magnification x40).
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F3
Histopathologic analysis revealed cytologically atypical melanocytes arranged in nests and singly along the dermoepidermal junction, with pagetoid spread highlighted by a MART-1 stain (melanoma antigen recognized by T cells) (Figure 3).
Extensive lentigines of the dorsal forearms and hands in a 21-year-old man following long-term voriconazole treatment (case 2). Similar lentigines were also present on the face.
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F4
They involved photoexposed areas, including the face and dorsal surfaces of the hands and forearms (Figure 4).