PMC3719122_01
a, b Clinical features: pinkish, firm, and dome-shaped nodules are seen in the chest.
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F1
The nodules in the chest were up to 0.5-1 cm in size, pinkish, firm and dome-shaped with a smooth surface (fig. 1a, b and fig. 2a).
a Clinical features: pinkish, firm, and dome-shaped nodules are seen in the chest. b Proliferation of neoplastic cells (HE: original magnification, 100x). c Atypical nuclei and clear cytoplasm and glandular structures in the dermis (HE: original magnification, 200x). d Positive staining of neoplastic cells with AE1:AE3 cytokeratin cocktail (original magnification, 320x). e Positive staining of neoplastic cells with prostatic acid phosphatase (original magnification, 320x). f Positive staining of neoplastic cells with PSA (original magnification, 250x).
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F2
A skin biopsy of an isolated nodule on the chest stained with hematoxylin and eosin showed monotonous sheets and small clusters of basophilic neoplastic cells filling the papillary dermis and diffusely permeating the reticular and deep dermis (fig. 2b). The nuclei have an open vesicular chromatin with prominent nucleoli (fig. 2c). IgG1 (DAKO), anti-human prostatic acid phosphatase clone PASE/4LJ isotype IgG1 (DAKO), monoclonal PSA clone ER/PR8, and isotype IgG1 (DAKO). Immunophenotypic studies for metastatic lesions showed the tumor cells staining positively for AE1:AE3 cytokeratin cocktail (fig. 2d), PSA (fig. 2e), and prostate-specific acid phosphatase (PSAP; fig. 2f).