PMC7750942_01
EEG recording analysis from a SUDEP patient. (A) iEEG recordings from the SUDEP patient with seizure onset identified by a red line and seizure offset by a blue line. Below are the corresponding global PAC throughout the recording. These results highlight the relatively low variability in the PAC, compared to coupling dynamics shown in Figs 1 and 2 and the presence of P(G)ES-like PAC features throughout the recording. (B) Scalp EEG recordings (simultaneous with iEEG in (A). Below are the corresponding global PAC throughout the recording. Note the predominance of the same PAC marker throughout the recording as in (A). (C) Single iEEG trace (from LOF1 electrode) centred around the seizure. This iEEG trace is classified using an HMM. Reference electrode:FCz.
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To see how SUDEP patients differ from our cohort (Patients 1-11), one SUDEP patient with concurrent scalp and iEEG recordings was used (Fig. 8). SUDEP patient, there was an absence of the PAC variability as previously observed in the other patients. Specifically, the PGES-like PAC features appeared throughout the recording, even though a seizure had been identified by an electroencephalographer (Fig. 8A and B; Supplementary Fig. 9 for zoomed in intracranial traces). Meanwhile, the S2 (ictal-like) state was largely absent (Fig. 8C) with only a short duration at the beginning of the seizure.