PMC9480177_01
A dome-shaped nodule, measuring 4cmx4cm on the left back (A). Purplish red and firm, with ulceration and hemorrhagic crust (B).
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The skin lesion was purplish red and firm, with ulceration and hemorrhagic crust (Figure 1).
Skin biopsy revealed tumor cells infiltrate in the dermis with extensive necrosis. The tumor cells had abundant and light staining cytoplasm, clear nucleolus, and obvious atypia (H&E, magnification: x200) (A). Immunohistochemical stain highlighted the tumor cells, showing CK-7 (B), TTF-1 (C) and Vimentin (D) positive (magnification: x200).
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The tumor cells had abundant and light staining cytoplasm, clear nucleolus, and obvious atypia (Figure 2A). TTF-1 and vimentin (Figures 2B-D), and negative for CK20 and CD5/6. The proliferative index, as measured by Ki-67, was over 90% of tumor cells.