PMC6555894_01
A. Rash on the patient's hand upon initial presentation. B. Section of skin biopsy with hematoxylin and eosin stain, original magnification 20 x . C. Photomicrograph of the skin biopsy showing large numbers of yeast forms surrounded by a clear space, typical of the thick capsule of Cryptococcus. (Mucicarmine, magnification 63x, courtesy of Dr. Bruce Burns).
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His rash consisted of multiple skin-colored to pink round papules with an erythematous rim, primarily over the patient's dorsal hands (Fig. 1a), face and posterior neck. A biopsy of the skin lesion was performed on day 2 of admission (pathology shown in Fig. 1b and c).
Cerebrospinal fluid A. Yeast cells on day 14 of treatment and B. Degenerating yeast cells on day 334 of treatment. (May-Grunwald-Giemsa, original magnification 100x oil immersion.).
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Repeat CSF on day 14 showed evidence of infection with presence of yeast cells visible by microscropy (Fig. 2a).