PMC7218455_01
Endoscopic image of esophageal tumor (A, arrow). Gross appearance of esophageal tumor: ulcerofungating mass in the upper esophagus shows grayish white-colored cut surface (B).
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The cut surface of the mass was grayish white (Figure 1).
Microscopic examination of the mass revealed neuroendocrine cell carcinoma (star) arranged with mixed squamous cell carcinoma (A, arrow; hematoxylin and eosin [H&E] staining, x100), (B; H&E staining, x200). Immunohistochemistry for synaptophysin (C) and cytokeratin 5/6 (D) were positive in tumor cells.
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Immunostaining for synaptophysin was positive, confirming the diagnosis of neuroendocrine differentiation (Figure 2).