PMC9893998_01
Endoscopic and histologic findings before (January 2011, first diagnosis) and after (September 2011, histologic complete remission [CR]) the first eradication treatment. a-c Before eradication. d-f After successful eradication. a, d Endoscopy. b, e Histology, x200. c, f Histology, x50.
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F1
GI endoscopy revealed reddish, uneven regions in the gastric body, suggestive of a superficial or gastritis-type gastric MALT lymphoma. Gastric pathology showed numerous invasions of small lymphocytes and the presence of lymphoepithelial lesions, and MALT lymphoma was confirmed by a pathologist (Fig. 1a-c). In September 2011, the endoscopic finding revealed a whitish, patchy, and scar-like gastric mucosa, which was suggestive of endoscopic remission; histologic diagnosis showed complete remission (CR) according to the Groupe d'Etude des Lymphomes de l'Adult (GELA) grading system (Fig. 1d-f).
Endoscopic and histologic findings before (February 2013, histologic responding residual disease [rRD]) and after (January 2016, histologic CR) the second eradication treatment of H. pylori reinfection. a, b Before eradication. c, d After successful eradication. a, c Endoscopy. b, d Histology, x100.
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F2
In February 2013, the endoscopic finding showed a reddish and uneven gastric mucosa, which was suggestive of the recurrence of MALT lymphoma; pathologic diagnosis revealed responding residual disease (rRD) according to the GELA system (Fig. 2a, b). In January 2016, an endoscopic examination demonstrated a whitish, patchy, flat, and scar-like gastric mucosa (endoscopic remission), and the histologic diagnosis showed CR according to the GELA system (Fig. 2c, d).
Endoscopic and histologic findings before (January 2017, histologic rRD) and after (April 2022, histologic CR) the third eradication treatment of H. pylori reinfection. a, b Before eradication. c, d After successful eradication. a, c Endoscopy. b, d Histology, x100. rRD, responding residual disease.
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F3
However, in January 2017, the endoscopic finding showed a reddish and uneven gastric mucosa, which was suggestive of the re-recurrence of gastric MALT lymphoma, and the histologic diagnosis showed responding residual disease according to the GELA system (Fig. 3a, b). In April 2022, the endoscopic finding revealed a whitish and scar-like gastric mucosa (endoscopic remission), and the histologic diagnosis showed CR according to the GELA system (Fig. 3c, d).