PMC7516288_01
(A) Effaced tonsillar architecture, replaced by diffuse sheets of atypical lymphoid cells (H&E x1). (B) A homogenous population of medium sized lymphocytes resembling centrocytes is seen, with irregular nuclear contours, condensed nuclear chromatin, inconspicuous nucleoli and scant cytoplasm (H&E x40).
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PMC7516288_01_gr1.jpg
fig1
No germinal centres were seen (Fig. 1).
Immunohistochemistry. (A) The tumor cells showing positivity for CD 20, (B) CD 5 and (C) Cyclin D1. Inset shows FISH for CCND1/IGH shows dual fusion signal with CCNDI/IGH translocation. (D) The cells are negative for CD 23.
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PMC7516288_01_gr2.jpg
fig2
MIB-1 activity was seen in about 40% of the cells (Fig. 2).