PMC5465650_01
Hematoxylin and eosin stains show intraepithelial spread of Paget cells involving the anal transitional zone. a The squamo-columnar junction is seen. b At the upper right corner (inset, x40) Paget cells with large cytoplasmic mucin globules and peripherally displaced nuclei are shown.
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f1
Rare Paget cells with extravasated mucin were suspicious for involving the superficial dermis, but otherwise there was no definitive invasion into the dermis or submucosa (Fig. 1, Fig. 2).