PMC6348813_01
Preoperative sagittal MRI with contrast demonstrating the homogenously contrast enhancing sellar/suprasellar mass with mass effect on the optic chiasm.
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Preoperative imaging obtained the following month in preparation for surgery demonstrated that the mass had grown to 2.2 x 1.5 cm (Figure 1).
Immediately postoperative sagittal MRI with contrast showing subtotal resection through an endoscopic endonasal approach.
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A subtotal resection (>80%) was achieved (Figure 2).
(a) Frozen section tissue showing interface between mucinous adenocarcinoma metastasis and adjacent adenohypophysis (arrow), H&E, 40x. (b) Metastatic mucinous adenocarcinoma showing clusters of moderately pleomorphic epithelial cells floating in pools of mucin separated by fibrovascular septae of variable thickness, H&E, 200x. (c) Cytokeratin CK8/18 is positive in tumor cells; immunohistochemical stain, 200x. (d) p16 shows nuclear positivity; immunohistochemical stain, 200x.
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Gross histology and immunohistochemical staining ultimately confirmed the diagnosis of metastatic mucinous adenocarcinoma of the cervix (Figures 3 and 4).
(a, b) Cervical biopsy showing a moderately differentiated mucinous/colloid adenocarcinoma. H&E, 40x (a) and 200x (b).
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Gross histology and immunohistochemical staining ultimately confirmed the diagnosis of metastatic mucinous adenocarcinoma of the cervix (Figures 3 and 4).
Postoperative sagittal MRI with contrast five weeks after surgery showing significant tumor recurrence.
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Follow-up MR imaging at five weeks after surgery revealed significant progression of the tumor to 2.9 x 2.4 cm with significant suprasellar extension (Figure 5).