PMC8565697_01
Histological features of angiosarcoma of the bladder. A, B. Low-power view of an invasive, high-grade spindle-cell neoplasm infiltrating through the bladder wall (HE, 50X).
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Microscopic examination showed an extensively invasive, high-grade neoplasm involving the bladder wall (Figures 1A and 1B), invading the full thickness of muscularis propria and perivesical adipose tissue but also the stroma of both prostatic lobes.
Histological features of angiosarcoma of the bladder: A, B. Morphological features including spindle and epithelioid pleomorphic cells (HE, 200X). C, D. High-power view of anastomosing blood-filled channels lined by atypical, hyperchromatic, endothelial cells (HE, 100X and 400X).
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Prostatic acinar adenocarcinoma (HE, 50X)
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Immunohistochemical stains showed expression of vascular markers CD31, CD34 (Figures 4A and 3B) in the tumor cells, patchy positivity for cytokeratin AE1/AE3 (Figure 4C) and negativity for p63 (Figure 4D).
Immunohistochemical stains: Diffuse expression of CD31 (A) and CD34 (B) in tumor cells (IHC, anti-CD31 and anti-CD34 Abs, 200X). Weak expression of CK AE1/AE3 (C) and negative p63 (D) in neoplastic cells (IHC, anti-cytokeratin AE1/AE3 and anti-p63 Abs, 100x and 200X, respectively).
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Immunohistochemical stains showed expression of vascular markers CD31, CD34 (Figures 4A and 3B) in the tumor cells, patchy positivity for cytokeratin AE1/AE3 (Figure 4C) and negativity for p63 (Figure 4D).