PMC9634216_01
Magnetic resonance imaging: T2 isointense to intermediate well-defined lesion in the right kidney.
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F1
T2 isointense, to intermediate well-defined lesion with diffusion restriction (Figure 1). The nephrometry score was eight. The patient underwent right partial nephrectomy.
Macroscopy: Partial nephrectomy specimen showing well circumscribed grey white tumour with no haemorrhage or necrosis, limited to kidney. Adjacent kidney is unremarkable. Resected margins are free.
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F2
No haemorrhage or necrosis was observed (Figure 2).
100x magnification of haematoxylin and eosin stained section of renal tumour: Sheets and fascicles of bland-appearing spindle cells.
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F3
Microscopic examination showed a neoplasm composed predominantly of bland-appearing spindle cells arranged in sheets and fascicles (Figure 3).
200x magnification of haematoxylin and eosin stained section of renal tumour. It shows focal tubular structures lined by bland cuboidal cells, intermingled with spindle cells, in a mucinous stroma.
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F4
The tumour was extensively sampled and embedded entirely which showed small foci of tubular structures lined by cuboidal cells intermingling with spindle cells (Figure 4).
200x magnification of CK7 immunohistochemistry. Cuboidal cells lining tubules and spindle cells show positive reaction for CK7.
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F5
Immunohistochemistry showed strong and diffuse positive reaction for pancytokeratin, CK7 (Figure 5), AMACR (Figure 6), PAX8, and vimentin, and negative reaction for SMA, S100, and CD34.
200x magnification of AMACR immunohistochemistry. Cuboidal cells lining tubules and spindle cells show positive reaction for AMACR.
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F6
Immunohistochemistry showed strong and diffuse positive reaction for pancytokeratin, CK7 (Figure 5), AMACR (Figure 6), PAX8, and vimentin, and negative reaction for SMA, S100, and CD34.