PMC8287873_01
Molecular Microscope Diagnostic System report. The yellow arrow shows the
biopsy. AMBR: antibody-mediated rejection; NR: normal; TCMR: T-cell-mediated
rejection; PC: principal component
mdcvj-17-02-e14-g1.jpg
PMC8287873_01_mdcvj-17-02-e14-g1.jpg
F1
Figure 1 A shows the main variation (principal component [PC], x-axis, normal vs. abnormal) compared to the second aspect of variation (PC2, y-axis, that separates ABMR from TCMR). Figure 1 B rotates the data cloud to show the third axis of variation (PC3, separating acute injury from rejection). Thus, our patient has TCMR (Figure 1 A) with injury secondary to TCMR (Figure 1 B) without evidence of ABMR.
Endomyocardial biopsy.
mdcvj-17-02-e14-g2.jpg
PMC8287873_01_mdcvj-17-02-e14-g2.jpg
F2
Mild rejection (grade 1R) is defined as interstitial and/or perivascular infiltrate with up to one focus of myocyte injury (as seen in Figure 2 A, B, green arrow).