PMC10098112_01
PMC10098112_02
Composite panel of six neuroimages showing the brain MRI study in the girl, at the age of 3.5 years: FLAIR-axial scan (A), T2-weighted coronal (B), and sagittal (C) sections; and coronal T1 3D scan (D), as well as reconstructions (reformat) derived from this last study both in axial (E) and sagittal (F) planes. A complex picture of microcephaly, partial agenesis of the corpus callosum with remnants of the genu (white arrow), simplified gyral pattern especially in the parietal and occipital regions of both hemispheres; enlarged and flattened ventricles (grey arrows), with colpocephaly and ectasia of temporal horns were also present. Apparently, no changes in myelin composition and cortical thickness were noticed (black arrows), even if the image protocol shown in this figure is of low quality due to partial panel reformatting. No signs or stigmata of TSC were detected within the brain (e.g., cortical tubers).
fped-11-1101026-g001.jpg
PMC10098112_02_fped-11-1101026-g001.jpg
F1
At that stage, brain MRI showed microcephaly with a small brain, simplified parieto-temporal gyral pattern, hypoplasia of the corpus callosum, with a residual draft of the genu, and enlargement and flattening of the ventricles, with colpocephaly and ectasia of the temporal horns (Figure 1).
PMC10098112_03