PMC7256308_01
Clinical features of Burkitt lymphoma skin lesions: A) group of erythematous papules and plaque on right temple and forehead (trigeminal nerve, V1 dermatome), B) group of erythematous papules on left forehead, and C) two erythematous nodules on right chest wall.
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Physical examination revealed a group of indurated, erythematous papules, and plaques on the right temple and forehead (distribution of trigeminal nerve, V1 dermatome) (Fig. 1A). A group of erythematous papules appeared on the left forehead (Fig. 1B) and two erythematous nodules located on the right chest wall (Fig. 1C).
Microscopic examination of skin biopsy specimen on chest (hematoxylin and eosin staining): A) low power revealed dense infiltration of medium-sized, round nuclei-lymphoid cells with condensed chromatin in the dermis and subcutaneous tissue with a grenz zone (x60); and B) tissue macrophages engulfed apoptotic tumor cells, which indicate a typical "starry sky" pattern (x300) in some areas of the dermis.
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The dermatopathology revealed dense infiltration of medium-sized, round nuclei-lymphoid cells with condensed chromatin in the dermis and subcutaneous tissue with a grenz zone (Fig. 2A). In some areas of the dermis, tissue macrophages engulfed apoptotic tumor cells, indicating a typical "starry sky" pattern (Fig. 2B).