PMC3699949_01
Multi-colored blackened macula on the right calf with an irregular border
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On physical examination, we observed a 3 cm blackened macula with an irregular border and more than one color on the right calf (Figure 1).
Peripheral atypical pigmented network structure (more marked on the right of the lesion), brownish streaks in the central area and right periphery, a peripheral area with a black blotch and some globular structures, an amorphous area with a pseudofollicular opening and pseudocysts on the left of the lesion, beyond the veil in the center of the lesion
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Dermoscopic examination showed a peripheral atypical pigmented network structure (more marked on the right of the lesion), brownish streaks in the central area and in the right periphery, a peripheral area with a black blotch and some globular structures, an amorphous area with a pseudofollicular opening and pseudocysts on the left of the lesion, beyond the veil in the center of the lesion (Figures 2 e 3). 
Details of the suspicious area biopsied
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Dermoscopic examination showed a peripheral atypical pigmented network structure (more marked on the right of the lesion), brownish streaks in the central area and in the right periphery, a peripheral area with a black blotch and some globular structures, an amorphous area with a pseudofollicular opening and pseudocysts on the left of the lesion, beyond the veil in the center of the lesion (Figures 2 e 3). 
Dermoscopy-guided incisional biopsy revealing a 0.37 mm-thick melanoma (panoramic view, x40, hematoxylin-eosin)
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A diagnosis of superficial spreading melanoma was rendered (Breslow thickness = 0.37 mm) (Figure 4). 
Excisional biopsy; the area of the blotch seen on dermoscopy was histologically related to acanthosis, papilomatosis, and extensive deposition of melanin pigment in the dermis (consistent with partial regression phenomenon)
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The area of the blotch seen on the dermoscopy was histologically related to acanthosis, papilomatosis, and extensive deposition of melanin pigment in the dermis (consistent with partial regression phenomenon) (Figure 5).