PMC5234301_01
Lumbar computed tomography scan: hyperdense lesion, suggestive of a calcified tumor
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F1
A lumbar magnetic resonance (MR) revealed with a lesion that was hypointense on T1 and T2-weighted images and showed no enhancement with contrast and no edema on fluid-attenuated inversion recovery studies [Figures 1 and 2].
T1- and T2-weighted magnetic resonance imaging shows hypointensity in both series and no enhancement by contrast
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F2
A lumbar magnetic resonance (MR) revealed with a lesion that was hypointense on T1 and T2-weighted images and showed no enhancement with contrast and no edema on fluid-attenuated inversion recovery studies [Figures 1 and 2].
Intraoperative image: intradural calcified lesion
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F3
She underwent an L2-L4 laminectomy and L3-L4 discectomy, as well as the resection of an L2 intradural tumor [Figure 3].
Histological section of calcifying nonneoplastic pseudoneoplasms stained for hematoxilin and eosin (a) and immunohistochemical expression for glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), and smooth muscle actin (b, c, and d, respectively). Optical microscopy, augmented x200 (blue bar); (a) extensive laminating and concentric arranged calcified lesion with bone formation trabecules associated with fibrous tissue; (b) small and round cell proliferation with minimal atypia surrounding the calcified and fibrous lesion which expressed GFAP; (c) strong and diffuse expression for EMA in the same surrounding cells which denotes ependymal differentiation; (d) fibro-osseous lesion immunostained for smooth muscle actin that demonstrated fibroblastic differentiation
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F4
Gross total resection of this extremely calcified lesion was accomplished [Figure 4].