PMC8557694_01
Changes in MRI brain over time. T2 FLAIR precontrast and T1 postcontrast images between initial presentation of symptoms and post-treatment with high-dose methotrexate and cytarabine consolidation. (A) Initial presentation, no contrast-enhancing lesions present. (B) One month after initial presentation, new contrast-enhancing lesions in the corpus callosum. (C) Post high-dose steroid administration, mild reduction in size of enhancing lesions. (D) Just prior to treatment with high-dose methotrexate. (E) Post-treatment with 8 high-dose methotrexate infusions and consolidation with cytarabine.
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F1
MRI of the brain revealed nonenhancing white matter abnormalities (Figure 1). Over the next several months, her brain MRI showed worsening fluctuations in enhancing and nonenhancing lesions (Figure 1). Based on these results, she was treated with 8 doses of rituximab and methotrexate with complete radiographic resolution of disease (Figure 1).