PMC7589533_01
A: Chest X-ray showed a tumor shadow in the right upper lung field and lower permeability in the right lower lung field.. B: Chest CT showed a tumor in the right S2 and pleural effusion in the right lung field.. C: Flexible bronchoscopy showed obstruction of laryngeal tumor in the right B2 bronchus.
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A 65-year-old man was referred to our hospital because of an abnormal shadow in the right upper lung field (Fig. 1).
A-C: Changes in pancreatic enlargement from a combination immunochemotherapy.. A: The normal pancreas before administration of a combination immunochemotherapy.. B: The pancreatic enlargement at diagnosis of irAE hepatitis and pancreatitis.. C: The improvement of the pancreatic enlargement after the treatment of PSL and AZA.
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Diffuse pancreatic swelling was detected on enhanced abdominal computed tomography (CT), although gallstone and common bile duct stones were not observed (Fig. 2). Pancreatic enzymes (amylase, trypsin and lipase) decreased and diffuse pancreatic swelling improved on CT (Fig. 2).
A,B: Histopathology of the liver biopsy showed centrilobular necrosis and inflammation (white arrow) (A: Hematoxylin and Eosin staining x 40, B: x 200).. C: Immunohistochemical staining showed that infiltration due to inflammatory cells was composed predominantly of CD8+ lymphocytes (CD8 staining by monoclonal anti-human CD8 mouse antibodies x 400).
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Immunostaining showed that the inflammatory infiltrate was composed predominantly of CD8+ lymphocytes (Fig. 3).
Clinical cource in our case.
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Liver enzymes decreased after the increase of PSL and the addition of AZA (Fig. 4).