PMC5466592_01
A - Chest CT showed a nodule with an irregular margin that measured 10 mm (larger diameter) in the RIL; B - Chest CT showed a nodule with a ground-glass opacity lesion that measured 23 mm (larger diameter) in the RUL.
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A1 - Adenocarcinoma with predominantly lepidic pattern (HE, x20); A2 - tall cylindrical mucous cells or globet-like cells (HE, x400); A3 - positivity with antibody anti-keratin 7 (K7, x100); B1 - Adenocarcinoma with predominantly lepidic pattern (HE, x20); B2 - small cuboidal or hobnail cells with hyperchromatic, irregular nuclei and prominent nucleoli (HE. x400): B3 - positivity with antibody anti-TTF1 (K7. x100).
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The mucinous adenocarcinoma from RUL showed negativity for keratin 20 and CDX2 antibodies, favoring a lung origin (Fig. 2).