PMC7201473_01
A 10 mm pedunculated polyp with a central ulceration was found in the rectum.
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A 10 mm reddish pedunculated polypoid lesion with a center ulcer was found in the rectum, 5 cm from the anus (Figure 1).
Histopathologic features of a rectal granular cell tumor. (a) The tumor was seen in the submucosa (hematoxylin and eosin staining, x12.5). (b) The tumor cells showed a polygonal or spindle-shaped cytoplasm with mild-to-moderate nuclear atypia and abundant eosinophilic granules (hematoxylin and eosin staining, x200). (c) Immunohistopathology staining with periodic acid-Schiff was positive (original magnification, x200). (d) Immunohistopathology staining for S-100 protein was positive (original magnification, x200).
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Pathologic results showed that the tumor invasion was restricted to the submucosa layer (Figure 2(a)). Tumor cells showed a polygonal or slightly spindle-shaped cytoplasm with mild-to-moderate nuclear atypia and eosinophilic and fine cytoplasmic granules (Figure 2(b)). The cytoplasmic granules had a positive reaction to periodic acid-Schiff staining (Figure 2(c)). Immunohistochemical staining for S-100 protein was also positive (Figure 2(d)).