PMC4601964_01
Large polypoid mass of the first toe of the left foot in a 37-year-old man (size, 9.5 x 8 cm). The surface shows irregular edges, necrotic and bleeding areas with several ulcerations.
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Physical examination revealed a 9.5 x 8 cm polypoid, necrotic mass of the first toe, with irregular edges, ulceration and bleeding (Fig. 1).
Low power view (H&E, 10x magnification) of superficial Ewing's sarcoma.
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Histological examination revealed a small round blue cell tumor occupying the dermis and subcutis and composed of cohesive sheets and trabeculae of uniform, small to medium round cells containing hypercromatic nuclei with small nucleoli and scanty pale cytoplasm with indistinct cytoplasmic borders (Figs. 2 and 3).
High power view (H&E, 20x magnification) of extraskeletal Ewing's sarcoma characterized by small round cell tumor of striking uniformity.
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Histological examination revealed a small round blue cell tumor occupying the dermis and subcutis and composed of cohesive sheets and trabeculae of uniform, small to medium round cells containing hypercromatic nuclei with small nucleoli and scanty pale cytoplasm with indistinct cytoplasmic borders (Figs. 2 and 3).
Strong immunoreactivity for CD99 in a characteristic membranous pattern.
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The tumor showed only focal cytoplasmic globular periodic acid Shiff (PAS) and was immunohistochemically positive for CD99 in a characteristic membrane pattern (Fig. 4).
11-month follow-up.
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The patient did not receive any adjuvant chemotherapy or radiotherapy according to oncologist consultation and after 11 months of follow-up period there is no evidence of recurrence (Fig. 5).