PMC3312656_01
Hyperpigmented and hypopigmented macules over dorsum of hands
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F1
A 10-year-old Indian boy presented with hyper and hypopigmented macules over the dorsa of hands and feet [Figure 1].
Hyperpigmented macules over both palms
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F2
There were hyperpigmented macules over both palms [Figure 2].
Freckle like macules over face
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F3
Freckle-like macules were present on his face that were not as numerous as hands and feet [Figure 3].
Mottled pigmentation over buttocks
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F4
His detailed examination revealed melanotic macules on the surface of axillaries and over the buttocks. [Figure 4].
PMC3312656_02
Biopsy from hyperpigmented macule showing abundance of melanocytes in basal layer and the presence of melanocytes in other epidermal layers (H and E stain, x400)
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F5
Biopsy from hypopigmented macule showed much less melanocytes [Figures 5 and 6].
Biopsy from hypopigmented macule showing relatively less melanocytes (H and E stain, x400)
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F6
Biopsy from hypopigmented macule showed much less melanocytes [Figures 5 and 6].