PMC9581649_01
Intense edema and erythema localized to the adherent vestibular gingival mucosa, from elements 1.5 to 2.5.
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The local objective clinical examination revealed intense edema and erythema localized to the adherent vestibular gingival mucosa, from elements 1.5 to 2.5 (Figure 1).
(a) The panoramic histological picture shows an oral mucosa punch biopsy, with highly cellular stroma (hematoxylin-eosin 20x). (b) At higher magnification, the oral mucosa appears spongiotic with mononuclear cell exocytosis, associated with dense stromal inflammation (hematoxylin-eosin 100x). (c) The stroma displays an intense infiltration of normal-appearing plasma cells (hematoxylin-eosin 200x). (d) Plasma cells are polyclonal, expressing both kappa (kappa light chain immunostaining 200x). (e) Lambda light chains (lambda light chain immunostaining 200x).
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The microscopic findings showed an intense inflamed infiltrate, predominantly plasmacellular, in the peripheral context of the lamina propria with edema and intra-epithelial spongiosis (Figures 2(a)-2(e)).
Intra-operative view, treatment performed with a diode laser, with a wavelength of 635 nm, 600-mum fiber, and a handpiece with 1 cm diameter lens. A power of 300 mW was used, with continuous emission mode and with application times not exceeding 1 minute/cm2 (fluence 22 J/cm2), carrying out grid-like scanning movements.
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A power of 300 mW was used, with continuous emission mode and with application times not exceeding 1 minute/cm2 (fluence 22 J/cm2), carrying out grid-like scanning movements (Figure 3).
The trend of measured values over time-related to: (a) Visual Analogue Scale (VAS) and (b) Numeric Pain Rating Scale (NPRS) denotes a decrease in reported symptoms.
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Furthermore, there were significant symptomatic reductions found after the first two therapeutic sessions (Figures 4(a) and 4(b)).
Six month after the end of treatment the mucous membranes of the lining appeared normo-chromic and normo-perfused in the absence of inflammation and symptoms.
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U/mL); Proteinase 3 antibodies: 21.8 (normally absent). Upon objective examination, the mucous membranes of the lining appear normo-chromic and normo-perfused in the absence of inflammation and symptoms (Figure 5).
At the last check carried out in 2022, the patient's mucous membranes did not show signs of inflammation or recurrence of the original lesions.
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