PMC5829697_01
Aspecto clinico: lesao nodular em labio superior.
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A male, 44-year-old, melanoderm patient sought care at an oral diagnosis service, presenting an asymptomatic increase in volume, with a lobulated surface, normochromic mucosal, fibrous consistency, located on the right side of the upper lip, and with duration of approximately 6 months (Figure 1).
Aspectos morfologicos e imuno-histoquimicos do angioleiomioma. (A) proliferacao de celulas com morfologias variadas (ovoides, fusiformes e onduladas) dispostas em feixes desorganizados e circundando multiplos vasos sanguineos (Hematoxilina & eosina, 100 microm); (B) Ausencia de imunomarcacao das celulas tumorais para proteina S100; (C) Positividade para CD34 restrita a parede vascular; (D-F) Imunomarcacoes fortes e difusas, respectivamente, para as proteinas alpha-SMA, H-caldesmon e desmina (100 microm).
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Examination of histological sections revealed a benign neoplasm of mesenchymal origin, located in a subepithelial region and characterized by proliferation of cells with a variety of morphologies (ovoid, fusiform, and ondulated), arranged in disorganized bundles that surrounded multiple blood vessels of several calibers (Figure 2A). The tumor cells were negative for S100 (Figure 2B), and positive staining for CD34 was restricted to the walls of blood vessels (Figure 2C). The tumor cells had intense staining for alpha-SMA (Figure 2D), and were immunopositive for H-caldesmon (Figure 2E) and desmin (Figure 2F).