PMC6313956_01
Cytological findings of the cardiac and pleural effusions. (A) Many small ball-like or papillary clusters in an inflammatory background (Papanicolaou stain, x100). (B) The neoplastic cells have rich granular cytoplasm and large round to oval nuclei with conspicuous nucleoli (Papanicolaou stain, x400).
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The Papanicolaou smears demonstrated numerous small ball-like or papillary clusters in an inflammatory background (Fig. 1A). These neoplastic cells had large round to oval nuclei with conspicuous nucleoli and coarse chromatin, and relatively rich granular cytoplasm (Fig. 1B).
Immunocytochemical findings of the cardiac effusion. (A) Androgen receptor is expressed in the nuclei of the neoplastic cells (x400). (B) Human epidermal growth factor receptor 2 is strongly expressed in the membrane of the neoplastic cells (x400).
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AR was diffusely expressed in the nuclei of the neoplastic cells (Fig. 2A). Strong membranous expression of HER2 was noted in the tumor cells (Fig. 2B).
Histopathological features of the right submandibular gland tumor. (A) Infiltrative neoplastic growth composed of variable-sized nests or irregular glandular formation (H&E, x40). (B) The neoplastic cells have rich eosinophilic cytoplasm and large round to oval nuclei containing conspicuous nucleoli (H&E, x400).
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The resected specimen showed infiltrative neoplastic growth composed of variable-sized nests or irregular glandular formation with invasion into the fatty tissue and nerve bundles surrounding the submandibular gland (Fig. 3A). The neoplastic cells had rich eosinophilic cytoplasm and large round to oval nuclei with conspicuous nucleoli (Fig. 3B).
Immunohistochemical features of the right submandibular gland tumor. (A) Androgen receptor is diffusely expressed (x200). (B) Strong membranous expression of human epidermal growth factor receptor 2 is noted (x400).
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The neoplastic cells diffusely expressed for AR (Fig. 4A). Strong membranous expression of HER2 was noted in the neoplastic cells (Fig. 4B).