PMC6084320_01
Light microscopy (AFOG 10x,PAS 40x) showed fibrin thrombi in glomerular capillary and arterioles and endothelial swelling in glomeruli with mesangiolysis and duplication of glomerular basement membrane and acute tubular injury with degenerating epithelium (A,B). Electron microscopy (recovered from paraffin block) disclosed fibrin thrombus in the capillary lumen (C), micro psammoma bodies in parietal cells of Bowman capsule (D) and endothelial membrane is lifted off the glomerular basal membrane by flocculent material that occupy the subendothelial space in the absence of electron-dense deposit (E).
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nep13086-fig-0001
A renal biopsy was performed to rule out malignancy-induced nephropathy, calcitonin amyloidosis or drug-related glomerulopathy.1 The biopsy showed thrombotic microangiopathy (TMA) (Fig. 1).