PMC7308452_01
Computed tomography (CT) scan revealing the presence of the skull lesion (A). MRI image of the solitary skull metastatic lesion (B).
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F1
The subsequent cranial magnetic resonance imaging (MRI) confirmed the presence of the osteolytic temporal-occipital lesion, with epidural extension and partial compression of the underlying brain parenchyma (Figures 1A,B).
Histological specimen: marked cellular pleomorphism, nuclear atypia, mitotic figures. Hematoxylin and eosin (H&E stain), X40 (A); Immunohistochemical findings: strong cell positivity for alfa-smooth muscle actin (a-SMA), X40 (B) and strong cell positivity for vimentin, X20 (C).
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F2
Histological exam showed the presence of spindle cells with moderate pleomorphism, 15 mitotic figures per 10 HPF (Figure 2A), and strong positivity for smooth muscle actin (SMA) (Figure 2B), vimentin, and desmin in immunohistochemistry (Figure 2C).