PMC5422500_01
Freckle-like brown macules and erythematous, indurated plaques with adherent scales.
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On examination, she had multiple erythematous, indurated plaques with adherent scales on some lesions over the cheeks and lips (Figure 1).
Reticulate hyperpigmented and hypopigmented macules on neck and upper chest.
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There were extensive freckle-like brown macules on her face, neck, and upper chest (Figure 2).
Reticulate hyperpigmented and hypopigmented macules on dorsa of hands.
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Moreover, she had both reticulated hyper-and hypopigmented macules over upper and lower limbs, especially over the dorsa of her hands and feet (Figure 3).
Discoid-like patch over the scalp.
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Scalp examination revealed a 2x1 cm, hairless plaque and decreased hair density all over her scalp (Figure 4).
H&E stain, original magnification x400.. Note: Biopsy specimen taken from a hyperpigmented macule shows abundance of melanin pigment in keratinocytes and melanocytes and a few scattered melanophages.. Abbreviation: H&E, hematoxylin and eosin.
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For the histopathological examination, biopsies were taken from both hypo- and hyperpigmented lesions (Figures 5 and 6).
H&E stain, original magnification x200.. Note: Biopsy specimen taken from a hypopigmented macule shows reduced melanin and number of melanocytes.. Abbreviation: H&E, hematoxylin and eosin.
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For the histopathological examination, biopsies were taken from both hypo- and hyperpigmented lesions (Figures 5 and 6).