PMC10257433_01
Clinical photograph showing gray pigmentation on the lower labial mucosa with ulceration.
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The lower left alveolar ridge and labial mucosa had an asymptomatic dark grey pigmentation of 2-3 cm associated with mild erythema and ulceration (Figure 1) without any changes in its size or shape.
Hematoxylin and Eosin Stain, magnification X200, showing inflamed and ulcerated mucosa with focal thickening of the basement membrane, spongiotic pustules and intraepithelial microabscesses.
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Epithelium shows focal spongiotic pustules and intraepithelial micro abscesses (Figure 2).
Hematoxylin and Eosin Stain, magnification X100 showing chronic inflammatory cell infiltrate present at the juxta epithelial and deeper connective tissue.
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Peri and para-vascular inflammatory cells are also noted within the deeper connective tissue (Figure 3).
Clinical photograph showing complete resolution of symptoms and pigmentation after discontinuing the dye.
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Although the patient was scheduled for a follow up after one month, the patient attended only after 2 years revealing complete resolution of symptoms and most of the pigmentation (Figure 4).