PMC8710691_01
The diagram shows the timeline of treatment and the changes in visual acuity and central retinal thickness.
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Then, she received treatment and follow-up by ophthalmologists, and the time course is shown in  Figure 1 .
Fundus examination of both eyes at the initial consultation. Ultra-wide field fundus image revealed macular edema in both eyes (A, B). The fluorescein angiograms did not reveal leakage from the parafoveal capillaries (C-F). Optical coherence tomography (OCT) B-scans showed the cystoid edema with a foveal thickness of 485 microm on the right and 596 microm on the left (G, H).
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The dilated fundus examination revealed macular edema in both eyes ( Figures 2A, B  ). The fluorescein angiograms did not reveal leakage from the parafoveal capillaries in early or late stages ( Figures 2C-F ). The optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) scans on both eyes revealed CME with a thickened central retina ( Figures 2G, H ,  3A ).
The change of macular edema by B-scan and en face optical coherence tomography and OCTA during the time course. (A) The OCT B-scan (a, f), OCTA (b, e), and en face OCT (c, d) revealed macular edema in both eyes at initial consultation; (B) One month after applying IVR (OCT B-scan g and l, OCTA h and k, en face OCT i and j); (C) One month after topical brinzolamide in both eyes. (OCT B-scan m and r, OCTA n and q, en face OCT o and p).
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The optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) scans on both eyes revealed CME with a thickened central retina ( Figures 2G, H ,  3A ). However, at 1 month after applying IVR, neither the BCVA of the patient nor the central retinal thinness detected by OCT was changed ( Figures 1 ,  3A  -a, f,  3B -g, l). However, the area of macular edema was reduced ( Figures 3A -b-e, B-h-k).