PMC9152181_01
CT-scan of the abdomen. Axial CT scan of the abdomen reveals a large abdominal mass measuring 10 x 8 x 10 cm without lymphadenopathy.
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F1
A thoraco-abdominal contrast-enhanced CT-scan, showed a 10 x 10 x 8 cm mass at the upper pole of the left kidney (Figures 1, 2) and no other suspicious lesions.
CT-scan of the abdomen. Coronal-view CT scan of the abdomen reveals a large abdominal mass measuring 10 x 8 x 10 cm without lymphadenopathy.
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F2
A thoraco-abdominal contrast-enhanced CT-scan, showed a 10 x 10 x 8 cm mass at the upper pole of the left kidney (Figures 1, 2) and no other suspicious lesions.
Pathological features. Macroscopically, The cut surface was heterogeneous with solid and microcystic features, hemorrhagic and necrotic areas, and some white nodules. The tumor was well-delimitated showing solid and microcystic features with hemorrhagic and necrotic areas. (A) Histologically, the tumor showed two main components. The central portion of the tumor was composed of ganglion cells at different stage of maturation, embedded in a fibrillary network (B) left portion of the image. The ganglion cells were positive for synaptophysin, chromogranin and MAP2 while they were negative for SF1, inhibin, MYC, CD99, cytokeratin, GFAP, and ATRX. SDHB was expressed. (C) The second component of the tumor was located at the periphery and included spindle Schwann cells positive for S100 (D).
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F3
The definitive diagnosis was nodular GNB (Figure 3).