PMC9582439_01
Multimodal imaging of multiple evanescent white dot syndrome (patient 1). (A) Color fundus imaging of the right eye showed subtle multifocal white dotted lesions in the posterior pole. (B) Optical coherence tomography showed discontinuities and attenuation of external limiting membrane and ellipsoid zone. (C) Fundus autofluorescence revealed scattered hyper-autofluorescence. (D) Fundus angiography showed punctate hyperfluorescence and staining of the venous wall. (E) Indocyanine green angiography (ICGA) demonstrated numerous hypocyanescent dots and spots, which outnumbered the lesions. (F) The static visual field test revealed blind spot enlargement and inferior defects in the right eye.
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F1
Color fundus imaging of the right eye showed subtle multifocal white dotted lesions in the posterior pole (Figure 1A). OCT showed discontinuities and attenuation of external limiting membrane and ellipsoid zone (Figure 1B). Fundus autofluorescence (FAF) revealed scattered hyper-autofluorescence (Figure 1C). Fluorescein angiography (FA) showed punctate hyperfluorescence and staining of the venous wall (Figure 1D). Indocyanine green angiography (ICGA) demonstrated numerous hypocyanescent dots and spots, which outnumbered the lesions (Figure 1E). The visual field test revealed blind spot enlargement and inferior defects in the right eye (Figure 1F).
PMC9582439_02
Multimodal imaging of multiple evanescent white dot syndrome (patient 2). (A) Color fundus imaging of the left eye showed normal fundus. (B) Optical coherence tomography showed a diminished ellipsoid zone in the peripapillary region. (C) Fundus autofluorescence (FAF) revealed several spotty hyper-autofluorescence. (D) Fundus angiography showed wreath-like hyperfluorescence in the late phase. (E) Indocyanine green angiography demonstrated numerous hypocyanescent dots and spots, which outnumbered the lesions on FAF. (F) The static visual field test revealed enlargement of the blind spot in the left eye.
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F2
Color fundus imaging of the left eye showed normal fundus (Figure 2A). OCT showed a diminished ellipsoid zone in the peripapillary region (Figure 2B). FAF revealed several spotty hyper-autofluorescence (Figure 2C). FA showed wreath-like hyperfluorescence in the late phase (Figure 2D). ICGA demonstrated numerous hypocyanescent dots and spots, which outnumbered the lesions on FAF (Figure 2E). The visual field test demonstrated blind spot enlargement in the left eye (Figure 2F).