PMC8214882_01
Gross examination of the tumor showing a mass with attached ileal segment and its cut surface (scale bar = 9 cm).
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The cut section was greyish-white and glistening with a myxoid appearance and soft to firm in consistency (Figure 1).
Histopathological examination of the tumor. A - Moderately cellular tumor with intervening small blood vessel (H&E, x100); B - Tumor cells with moderate eosinophilic cytoplasm and oval to spindle nuclei (H&E, x200); C - Myxoid area along with mild lymphoplasmacytic inflammatory infiltrate (H&E, x200); D - Epithelioid to round cell morphology of tumor cells with conspicuous nucleoli and few binucleated forms (H&E, x400).
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On the histopathological examination, the tumor consisted of epithelioid to spindle cells loosely arranged in a myxoid background with numerous blood vessels (Figure 2).The tumor cells had moderate eosinophilic cytoplasm, oval to spindle nuclei, and conspicuous nucleoli.
Immunohistochemistry. A - Tumor cells showing ALK nuclear membranous positivity (inset) (x400); B - Diffuse desmin positivity (x400); C - SMA positivity (x400); D - Focal CD30 positivity (x200).
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A large panel of IHC was applied, and the tumor cells showed positivity for ALK1 (nuclear membrane), desmin, SMA, CD68, and focal positivity for CD30 (Table 1) (Figure 3).