PMC3413338_01
Case 1. (A) Slit-lamp photograph of right cornea.
Geographic-shaped abnormalities in the central cornea are magnified in the
lower right box. (B) In vivo laser confocal microscopic images
of corneal lesions. Highly reflective linear images in the basal epithelium
(depth 28 mum). (C) Highly reflective curvilinear,
multilaminar lines in the basal epithelium (depth 20 mum).
(D) Ring-shaped highly reflective extracellular deposits in
the basal epithelium (depth 25 mum). (E) Highly
reflective irregular deposit in the basal epithelium (depth 29 mum).
(F) Highly reflective geographic opacities in the basal
epithelial layer (depth 22 mum). (G) Highly reflective
needle-shaped structures were also observed in the stroma (arrows, depth 445
mum). (H) Highly reflective microdots were observed in
the stroma (depth 74 mum). Note: Bar 100 mum.
opth-6-1187f1.jpg
PMC3413338_01_opth-6-1187f1.jpg
f1-opth-6-1187
By slit-lamp biomicroscopy, geographic-shaped abnormalities were observed in the Bowman's membrane level in both eyes (Figure 1A).
PMC3413338_02
Case 2. (A) Slit-lamp photograph of right cornea.
Fingerprint-shaped abnormalities in the central cornea are magnified in the
lower right box. (B and C) In vivo laser confocal
microscopic images of corneal lesions. Multiple dark parallel striae in the
superficial/basal epithelium and Bowman's membrane layer (arrows,
depth 22 mum and 25 mum, respectively). (D)
Infiltration of possible Langerhans cells in Bowman's membrane cell
layer (depth 51 mum, arrows). (E) Highly reflective dots
were observed in the basal epithelial layer (depth 60 mum, arrows).
(F) Highly reflective microdots were observed in the stroma
(depth 80 mum).. Note: Bar 100 mum.
opth-6-1187f2.jpg
PMC3413338_02_opth-6-1187f2.jpg
f2-opth-6-1187
By slit-lamp biomicroscopy, fingerprint-shaped abnormalities were observed in the Bowman's membrane level in both eyes (Figure 2A).