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Gross specimen of a massive spleen weighing 6400 grams Note the multiple capsular lacerations present (arrows).
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An autopsy performed revealed a markedly enlarged spleen measuring 30 cm x 20 cm x 10 cm, weighing 6400 grams, with multiple foci of capsular lacerations noted (Figure 1).
Liver tissue with a nodular pattern of lymphocytic infiltration noted.
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Histopathologic examination of splenic tissue showed massive nodular infiltration of the spleen by small cleaved lymphocytes (Figures 2 and 3).
Histopathology of splenic tissue. Note the presence of small cleaved cells (centrocytes) suggestive of mantle cell non-Hodgkin's lymphoma.
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Histopathologic examination of splenic tissue showed massive nodular infiltration of the spleen by small cleaved lymphocytes (Figures 2 and 3).
Immunohistochemical staining positive for cyclin D-1 correlating with the t(11; 13) translocation of the short arm of chromosome 13, which is highly specific for MCL.
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Immunohistochemistry results supported the diagnosis of NHL of mantle cell type (Figures 4 and 5; Table 1).
Immunohistochemical staining revealing BCL-2 positivity.
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Immunohistochemistry results supported the diagnosis of NHL of mantle cell type (Figures 4 and 5; Table 1).