PMC6506456_01
Cerebral magnetic resonance (cMRI) imaging showing generalized atrophy with perisylvian accentuation.
fpsyt-10-00270-g001.jpg
PMC6506456_01_fpsyt-10-00270-g001.jpg
f1
The cMRI showed generalized atrophy (Figure 1).
Magnetic resonance spectroscopy (MRS) findings: We present the findings of the dorsal anterior cingulate cortex (dACC; the two upper rows) and the pregenual anterior cingulate cortex (pACC; lower rows). The patient's values (red line) are compared to the values of a healthy control group measured in another study (N = 43, mean age: 35, gender ratio: 14 females/29 males). The green line shows the 90% reference interval of the control group. For Glx in the dACC and Ins in the pACC the green (90% reference interval) and the red line (patient's values) are superimposed, therefore only the red line is visible. The measured metabolite concentrations have been corrected for MRS voxel composition (content of gray matter, white matter, and cerebrospinal fluid), as well as for the influence of age and differences in the signal-to-noise ratio of the MRS measurements. Abbreviations: GABA, gamma-aminobutyric acid including coedited macromolecules; NAA, N-acetylaspartate; Glx, glutamate and glutamine; Glu, glutamate; Ins, myo-inositol; GPC, glycerophosphorylcholine.
fpsyt-10-00270-g002.jpg
PMC6506456_01_fpsyt-10-00270-g002.jpg
f2
The myo-inositol concentrations in the pACC were relatively low and within the 90% reference interval (Figure 2).