PMC9873443_01
MRI images of the patient's brain. (a, b) T1 postcontrast coronal sequences of the brain showing multiple cystic lesions of varying sizes in the cerebral hemispheres. (c, d) T1 postcontrast axial sequences of the brain showing multiple cystic lesions of varying sizes in the cerebral hemispheres.
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fig1
MRI brain showed numerous bilateral intraparenchymal cystic enhancing lesions, some of which demonstrated internal hemorrhagic components (Figure 1).
Histology images of the biopsy specimen of the Brain. (a) Hematoxylin and eosin photomicrograph high power view (400x) of high-grade small ovoid poorly differentiated neoplastic cells with a high N:C ratio (curved arrows) in the brain parenchyma (straight arrow). (b) Hematoxylin and eosin photomicrograph low power view (100x) of high-grade small ovoid poorly differentiated neoplastic cells with a high N:C ratio (curved arrow) with scant areas of the brain parenchyma (straight arrows).
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fig2
The pathology of the specimen showed high-grade, nonlymphoid neoplasm favoring glioblastoma with undifferentiated small cell components (Figure 2) with O-methylguanine-DNA-methyltransferase (MGMT) promoter methylated.