PMC5846222_01
(a) Stereotactic biopsy showing tumor along with a granuloma (arrow) (H and E, x20); (b) polygonal tumor cells, round vesicular nucleus, abundant cytoplasm; (c) granuloma showing Langhans giant cell, epithelioid cells, and lymphocytes (H and E, x40); (d) placental alkaline phosphatase positivity (DAB, x10); (e) CD117 positivity (DAB, x40)
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F1
The lesion showed predominant granulomatous response with collections of Langhans type of giant cells, epithelioid cells with a peripheral cuff of lymphocytes [Figure 1a and b]. Adjacent to this, there was a minor component of undifferentiated round cells with moderate to abundant clear cytoplasm, round nucleus with inconspicuous nucleoli [Figure 1c. PLAP and CD 117 showed diffuse membranous positivity in the tumor [Figure 1d and e], thus confirming the diagnosis of germinoma.
Squash smear showing tigroid background and dual population of cells; large polygonal tumor cells with vesicular chromatin, moderate amount of fragile vacuolated cytoplasm (arrow head) and mature lymphocytes in the background (arrow) (May Grundwald Giemsa X400)
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F2
The background was tigriod and showed scattered mature lymphocytes [Figure 2].