PMC3385281_01
Clinical photograph (after biopsy) of case 1 showing residual ulcerated light red plaque on medial aspect of left leg
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F1
Recently, the lesion was rapidly increasing in size and subsequently ulcerated [Figure 1].
Photomicrograph (low power) showing diffuse nonepidermotropic infiltrates of tumor cells in the papillary and reticular dermis (Hematoxylin and Eosin, x100)
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F2
The tumor cells were located in the papillary and reticular dermis and reaching the interface between dermis and subcutis [Figure 2].
Photomicrograph showing CD20 positivity (cytoplasmic membrane) by tumor cells (x400)
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F3
Immunohistochemistry (IHC) revealed expression of CD20, CD19, Bcl-2, Bcl- 6 and MUM-1 by tumor cells, while they were negative for CD10, CD30, EMA, CD3, and CD5 [Figures 3 and 4].
Photomicrograph showing Bcl-6 positivity (nuclear) by tumor cells (x100)
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F4
Immunohistochemistry (IHC) revealed expression of CD20, CD19, Bcl-2, Bcl- 6 and MUM-1 by tumor cells, while they were negative for CD10, CD30, EMA, CD3, and CD5 [Figures 3 and 4].
PMC3385281_02
Photomicrograph (high power) showing monomorphic large cells arranged in diffuse sheets. The cells have the high nuclearcytoplasmic ratio and prominent single to multiple nucleoli (Hematoxylin and Eosin, x400)
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F5
Incisonal biopsy was taken and histopathological examination revealed similar findings as in case 1 [Figure 5].