PMC6613258_01
Time course of values for doripenem and other laboratory tests. The concentration of unbound doripenem in serum was 47.8 mug/mL at 20 h after dosing was started, and decreased to 33.6 mug/mL at 111 h. All biomarkers that acted as an indicator of infection were included in the calculations for the respective normal ranges. The serum concentration of tobramycin was measured on Day 1 before the admission of the patient to the ICU (peak, 16.5 mug/mL; trough, 4.3 mug/mL); the tobramycin dose was then decreased from 5.3 mg/kg/day to 2.7 mg/kg/day. CRP, C-reactive protein; CRRT, continuous renal replacement therapy; AN69-ST, a dialyzer membrane made by polyacrylonitrile (surface-treated)
40780_2019_144_Fig1_HTML.jpg
PMC6613258_01_40780_2019_144_Fig1_HTML.jpg
Fig1
The time course of the values for the concentration of unbound doripenem in the serum and the values from other laboratory tests during the patient's stay at the ICU are presented in Fig. 1.