PMC7522090_01
Axial T2 weighted (A) and axial contrast-enhanced T1-weighted (B) MRI obtained at presentation demonstrates multifocal, bifrontal poorly marginated enhancing mass lesions with surrounding vasogenic edema.
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Brain MRI demonstrated multifocal mass lesions (Fig. 1).
Axial non-contrast chest CT (A) and PET (B) an FDG-avid mediastinal lymph node (arrows).
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A repeat CT chest and PET-CT demonstrated several scattered FDG-avid sub-centimeter mediastinal lymph nodes (Fig. 2), which underwent subsequent mediastinoscopic biopsy, ultimately revealing necrotizing granulomas.
Axial T2 weighted (A) and axial contrast-enhanced T1-weighted (B) MRI obtained after initiation of RIPE therapy demonstrate recurrent multifocal, bifrontal poorly marginated enhancing mass lesions with surrounding vasogenic edema.
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Due to high degree of suspicion for PCNSL, repeat brain MRI at 8 weeks following initiation of anti-TB treatment was done, demonstrating recurrent multifocal, bifrontal enhancing mass lesions (Fig. 3).