PMC6183698_01
Plain lateral radiographs and MRI demonstrated a fresh vertebral fracture at L3 and T12.. Abbreviations: L, lumbar; T, thoracic.
cia-13-1929Fig1.jpg
PMC6183698_01_cia-13-1929Fig1.jpg
f1-cia-13-1929
Plain lateral radiographs of the spine and MRI demonstrated a fresh vertebral fracture at L3 and T12 (Figure 1).
Serum calcium and intact PTH levels.. Notes: After the serum calcium was normalized, it did not change significantly over the three courses of denosumab. PTH continued to be elevated 2 weeks following denosumab administration. Subsequently, PTH was normalized owing to calcium supplementation.. Abbreviations: M, month; Ca, calcium; PTH, parathyroid hormone.
cia-13-1929Fig2.jpg
PMC6183698_01_cia-13-1929Fig2.jpg
f2-cia-13-1929
D supplementation (Figure 2). During denosumab treatment, there was an immediate reduction in bone turnover markers (Figure 3) and a successful increase in the BMD (DXA: spine BMD, from 0.594 to 0.893 mg/cm2; femoral neck BMD, from 0.445 to 0.456 mg/cm2).
Bone turnover markers (TRACP-5b, total-P1NP) and eGFR levels.. Notes: TRACP-5b and total-P1NP levels decreased immediately following the first course of denosumab treatment. Renal function diminished mildly over the entire course of treatment.. Abbreviations: M, month; TRACP-5b, tartrate-resistant acid phosphatase type 5; total-P1NP, total N-terminal propeptide of type 1 procollagen; eGFR, estimated glomerular filtration rate.
cia-13-1929Fig3.jpg
PMC6183698_01_cia-13-1929Fig3.jpg
f3-cia-13-1929
D supplementation (Figure 2). During denosumab treatment, there was an immediate reduction in bone turnover markers (Figure 3) and a successful increase in the BMD (DXA: spine BMD, from 0.594 to 0.893 mg/cm2; femoral neck BMD, from 0.445 to 0.456 mg/cm2). There was a mild deterioration in renal function during the course of his treatment (Figure 3). 1,25(OH)2D was suppressed, while 25(OH)D increased in summer and autumn and decreased in winter (Figure 4).
1,25(OH)2D and 25(OH)D levels.. Notes: 1,25(OH)2D was suppressed following eldecalcitol supplementation. 25(OH)D level is higher in summer and autumn and lower in winter.. Abbreviations: M, month; 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin.
cia-13-1929Fig4.jpg
PMC6183698_01_cia-13-1929Fig4.jpg
f4-cia-13-1929
There was a mild deterioration in renal function during the course of his treatment (Figure 3). 1,25(OH)2D was suppressed, while 25(OH)D increased in summer and autumn and decreased in winter (Figure 4).