PMC8416249_01
Liver histology showed normal lobular architecture with few lymphocytes, monocytes and neutrophils infiltrating the portal areas were seen in (A) (H&E x 100). Extensive cholestasis of hepatocytes and the formation of bile embolism were better observed at a higher magnification in the centrilobular zone 3 on (B) (H&E x 400).
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F1
Immunohistochemical staining of hepatitis B surface antigen and hepatitis B core antigen, periodic acid-Schiff staining, copper staining, and iron staining were negative (Figure 1).
ATP8B1 c.1817T >C variant identified in the parents of our patient. We can deduce that his variant is potentially derived from his parents.
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F2
Aggregation Database (gnomAD), Human Gene Variant Database, and Clinvar of NCBI. A familial genetic testing by sanger sequencing showed heterozygosity in his parents' ATP8B1 genes (Figure 2).