PMC8188895_01
Interventions timeline.
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F2
Reexamination of the patient using CT revealed subdural effusion (Figure 1E). A postoperative CT scan was fused with a preoperative MRI to localize the lead positions and demonstrated that they were accurately implanted into the NBM (Figure 1F). Compared to baseline assessments, the patient displayed an improvement in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog), from 43 to 33 points, with changes in word recall (1-point reduction), naming objects and fingers (1-point reduction), commands (2-point reduction), constructional praxis (2-point reduction), ideational praxis (2-point reduction), word recognition task (3-point reduction), and remembering test instructions (1-point increase) (Figure 1I), suggesting a significant improvement with NBM-DBS in the short term. Notably, the patient's executive functions (structure identification and imitation) also improved (Figures 1G,H), and he could remember the names of his children during NBM-DBS:something he could not do before DBS.