PMC4238175_01
Histology: portal tract with mild lymphocytic inflammatory infiltrate with eosinophils and focal interface hepatitis (HE, 40x).
CRIHEP2013-406901.001.jpg
PMC4238175_01_CRIHEP2013-406901.001.jpg
fig1
Adalimumab was started in April 2010, and at the third month liver function tests showed a rise of GgT (23 times the upper normal limit), AP (2.5 times the upper limit) and AST, ALT with no change (1.5 nv), and pruritus. A liver biopsy was then performed with an A1 F2 pattern, portal dystrophy, portal inflammation with eosinophils, lobular hepatitis, and microabscesses (Figures 1 and 2).
Histology: fibrous portal expansion with short septa. (TRI 40x).
CRIHEP2013-406901.002.jpg
PMC4238175_01_CRIHEP2013-406901.002.jpg
fig2
Adalimumab was started in April 2010, and at the third month liver function tests showed a rise of GgT (23 times the upper normal limit), AP (2.5 times the upper limit) and AST, ALT with no change (1.5 nv), and pruritus. A liver biopsy was then performed with an A1 F2 pattern, portal dystrophy, portal inflammation with eosinophils, lobular hepatitis, and microabscesses (Figures 1 and 2).