PMC7708968_01
Plain radiograph demonstrates a soft-tissue lesion with specks of calcification (arrow) and intact underlying cortices of the humerus (a). Fine-needle aspiration smears showing low cellularity (b, Giemsa, x10) and few groups of round to polygonal cells in the inset (Giemsa, x40). Prominent nuclear pleomorphism (c, Giemsa, x40), better seen in inset (arrow) and occasional multinucleated osteoclast-like giant cell marked by arrow (d, Giemsa, x40) are seen.
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F1
The cytomorphological features are shown in Figure 1.
Histological photomicrographs showing a cellular tumor (a, H&E, x10) with prominent osteoid production (b, H&E, x40). The osteoid is directly in contact with the pleomorphic tumor cells.
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F2
Histopathologic examination of the lesion showed a tumor composed of pleomorphic round to polygonal cells with bizarre nuclear shapes and frequent mitotic figures [Figure 2a]. Abundant neoplastic osteoid was seen surrounding the cells without any interposition of cartilaginous component between the cells and osteoid [Figure 2b].