PMC5442215_01
Representative histologic section of undifferentiated pleomorphic sarcoma with giant cells obtained from the anterior right ankle mass. (A) Osteoclastic-like multinucleated cells mixed with pleomorphic and predominantly atypical round cell population (H-E, x100), (B) Multinucleated giant cells admixed with tumor pleomorphic cells with atypical mitosis (H-E, x100), (C) Hemorrhagic areas (H-E, x100), and (D) Osteoclastic giant cells with irregular nuclei and prominent nucleoli. The pleomorphic cells have much longer nuclei (H-E, x200).
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F1
This histopathologic pattern defines the lesion as UPS with giant cells (Figure 1).