PMC10424124_01
MRI and FDG-PET CT. Axial non-contrast MRI brain shows diffuse atrophy, particularly in the right greater than left frontal and parietal regions (B and C) and right greater than left midbrain atrophy (A). Fluorodeoxyglucose positron emission tomography-computed tomography scan shows hypometabolism in the supratentorial white and grey matter, most severe in the right frontal lobe (D).
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She had a fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT) scan, which showed hypometabolism in the supratentorial white and grey matter, most severe in the right frontal lobe (Fig. 1). Her magnetic resonance imaging (MRI) study of the brain without contrast was notable for diffuse atrophy, particularly in the right greater than left frontal and parietal regions, as well as atrophy of the midbrain, affecting the right midbrain more than the left (Fig. 1).
Family pedigree. This family pedigree includes four generations. Our proband is indicated by an arrowhead. An autosomal dominantly inherited neurodegenerative process is suggested based on the family history provided.
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Her family history was significant for autopsy-confirmed frontotemporal dementia diagnosed in her mother and older sister, and a history of unspecified dementia in her maternal grandfather and maternal uncle (Fig. 2).