PMC5892324_01
Fundus photographs of the patient's right eye obtained before and after Gamma Knife  (GK) radiosurgery treatment. Choroidal melanoma was observed from the macular region to the temporal side (a). Although the tumor gradually shrank after GK treatment, hard exudates began to appear around the tumor at 6 months postoperatively (b).
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F1
However, in the fundus of her right eye, a grayish-white choroidal tumor-like lesion, 7 disc diameters in size, was observed from the macular region to the temporal side (Fig. 1a). Although the tumor gradually shrank after GK treatment, hard exudates began to appear around the tumor at 6 months postoperatively (Fig. 1b).
Fundus photograph and optical coherence tomography (OCT) images obtained at 8 years after the initial treatment. A bullous retinal detachment with fixed folds occurred in the superior-nasal quadrants (a). OCT revealed partial thinning of the macular retina, with the formation of a retinal inner break caused by traction resulting from the formation of preretinal membrane and posterior vitreous detachment (b).
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F2
Upon examination, we found that a bullous retinal detachment with fixed folds had occurred in the superior-nasal quadrants of her right eye (Fig. 2a), and that the corrected VA was light perception. Optical coherence tomography (OCT) findings revealed a partial thinning of the macular retina, with the formation of a retinal inner break caused by traction resulting from the formation of preretinal membrane and posterior vitreous detachment (Fig. 2b).
MRI and 123I-IMP SPECT images obtained at 8 years after the initial treatment. MRI showed no increase in tumorous lesions (a), and 123I-IMP SPECT imaging revealed no photon accumulation (b), thus indicating no tumor activity.
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F3
Serum levels of 5-S-cysteinyldopa (5-S-CD), a tumor marker for CM, were within the normal range of 2.1 nmol/L, MRI findings showed no increase in tumorous lesions (Fig. 3a), and 123I-IMP SPECT imaging showed no photon accumulation (Fig. 3b), thus indicating that there was no tumor activity.