PMC5138457_01
The polypoid lesion was identified as a whitish elevation covered with smooth surface. The polyp was successfully removed with endoscopic resection.
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fig1
The polyp was successfully removed with endoscopic resection (Figure 1).
Irregularly branched neoplastic glands covered with the nonneoplastic foveolar epithelium (H&E x40).
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fig2
Microscopically, the polyp was composed of irregularly branched neoplastic glands covered with the nonneoplastic foveolar epithelium (Figure 2).
Continuity between the neoplastic glands and the fundic glands, indicating that the tumor arouse from the fundic gland (H&E x100).
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fig3
Continuity between the neoplastic glands and the fundic glands was clearly identified, indicating that the tumor arose from the fundic glands (Figure 3).
Occasional neoplastic cells showing oxyntic cytoplasm (H&E x200).
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fig4
The tumor cells exhibited mildly enlarged atypical nuclei with occasional cells showing oxyntic cytoplasm (Figure 4).
Submucosal invasion with complete disruption of the muscularis mucosae (a) (desmin immunostain x40) and mild lymphocytic and fibroblastic stromal reaction (b) (H&E x200).
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fig5
The tumor invaded the submucosa with complete disruption of the muscularis mucosae and demonstrated mild lymphocytic and fibroblastic stromal reaction (Figures 5(a) and 5(b)).
The neoplastic glands are diffusely reactive for MUC6 (a) (MUC6 immunostain x200) and pepsinogen-I (b) (pepsinogen-I immunostain x200).
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fig6
Immunohistochemistry demonstrated that the neoplastic glands were strongly and diffusely reactive for MUC6 and pepsinogen-I (Figures 6(a) and 6(b)) and nonreactive for MUC2 and MUC5AC, confirming a gastric immunophenotype.