PMC5348461_01
(a) Laryngoscopy revealed that the patient's throat was full of swollen ulcers with white plaque (marked by arrows). (b) Fiberoptic bronchoscopy demonstrated some irregular, nodular materials with white moss, which completely obstructed the bronchial wall. (c) Chest computed tomography (CT) revealed no specific findings. (d) A histopathological examination of the biopsy specimen revealedAspergillus spp.
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However, the persistent cough did not improve and hoarseness developed after two weeks of treatment - ulcers were then observed in the throat by laryngoscopy (Fig. 1a). Fiberoptic bronchoscopy revealed an irregular, nodular material with white moss, which nearly obstructed the bronchus; however, chest CT imaging was negative (Fig. 1b and c). The histopathological examination of biopsy specimens revealed an Aspergillus species (Fig. 1d).
(a) The previous ulcers and nodules in the throat completely disappeared under bronchoscopy after the a combination anti-fungal therapy was administered for 2 weeks. (b) A repeat chest CT scan showed nonsegmental consolidation in the left lower lobe with the disappearance of the laryngeal lesions.
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The combination therapy continued for 2 weeks, until the previous nodules in the throat completely disappeared under bronchoscopy (Fig. 2a); however, a repeat chest CT scan showed progression (Fig. 2b).