PMC8478086_01
A 4-cm, protruding, ulcerated, fleshy, firm tumor with a moist and granular surface.
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Multiple scaly erythematous papules with yellowish crusts were observed on the margins of the lesion (Figure 1).
Basaloid neoplasm in lobules and sebaceous cells with vacuolated cytoplasm in the dermis (hematoxylin and eosin; magnification: 10x10).
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Histopathology demonstrated a basaloid neoplasm in lobules and sebaceous cells with vacuolated cytoplasm in the dermis under low power observation (magnification: 10x10) (Figure 2).
Ample coarse cells with atypical nuclei (magnification: 40x10).
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In addition, ample coarse cells with atypical nuclei were found at high magnification (magnification: 40x10) (Figure 3).
Positive immunohistochemical epithelial membrane antigen stain (magnification: 10x10).
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Immunohistochemical staining, including a positive epithelial membrane antigen (EMA) stain (Figure 4), confirmed sebaceous differentiation of the anaplastic cells, supporting the diagnosis of SC.
Timeline.
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Unfortunately, the patient died of unknown causes before initiation of the planned tests and treatment (please see Figure 5:Timeline).