PMC3375673_01
The biopsy sample of the jejunum illustrating complete effacement due to centrocyte like cells and plasma cells in the in mucosa and submucosa (HEx50 and 100)
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Histological examination of the excised jejunal biopsy showed subtotal villous atrophy and dense lymphoplasmacytic infiltration limited to mucosa and submucosa (Figure 1).
CD 20 staining shows marked positivity of the lymphoid cells noted in the mesenteric lymph node (CD20x100)
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CD 20 were found positive in the mesenteric lymph node (Figure 2).
CD 20 staining shows marked positivity of the lymphoid cells noted in the intestinal mucosa (CD20x100)
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In the immunohistochemical analysis of the intestinal and lymph node biopsy material, LCA, CD-79, CD-20 and IgA were found positive while kappa and lambda heavy chain, IgD and IgM were found negative (Figure 3).
The bone marrow aspirate smear shows markedly increased number of lymphoplasmacytic (MGG stain Oil immersion X1000)
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Bone marrow aspiration and biopsy revealed diffuse lymphoplasmacytic infiltration (Figure 4).