PMC9561900_01
Single-cell transcriptome analysis of nasal brush isolated from a chronic SARS-CoV-2 infection. The two-dimensional t-distributed stochastic neighbor embedding (t-SNE) plot, based on n = 2,838 cells, shows the distribution of SARS-CoV-2-infected cells (red dots) into each cluster, representing a different cell type.
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f1
A total of 2,838 cells were recovered from the analysis, which were clustered and classified based on their expression patterns, as shown in  Figure 1 . As shown in  Figure 1 , viral RNAs were identified mostly in epithelial cells (red dots, N = 14/16), with residual positivity also in macrophages and T cells (N = 1 each, respectively).
Timeline including the virological course and COVID-19-related symptoms in patients 1 and 2.
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April 2022, the patient is in fair clinical conditions, and he started venetoclax therapy. A timeline including the clinical and virological courses is presented in  Figure 2 .
PMC9561900_02
Timeline including the virological course and COVID-19-related symptoms in patients 1 and 2.
fonc-12-945060-g002.jpg
PMC9561900_02_fonc-12-945060-g002.jpg
f2
April 2022, the patient is in fair clinical conditions, and he started venetoclax therapy. A timeline including the clinical and virological courses is presented in  Figure 2 .