PMC8477662_01
Case 1 images. (A,B) Brain magnetic resonance T1-weighted images. None of them showed any abnormalities. (C) N-isopropyl-p-[123I] iodoamphetamine (123I-IMP) single-photon emission computed tomography (SPECT) not showing any particular abnormalities. (D) Cardiac [123I]-metaiodobenzylguanidine scintigraphy. Heart-to-mediastinum ratios were 3.33 and 2.28 in early and delayed phases, respectively. The washout ratio was 48.8%. (E) 2beta-carbometoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (FP-CIT) SPECT. The specific binding ratios were 6.53 and 6.04 in the right and left striatum, respectively. The asymmetry index was 7.9%. (F) Florbetapir 18 positron emission tomography showing positive results.
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F1
Brain magnetic resonance imaging (MRI) showed almost no visually-rated cerebral atrophy, no cerebrovascular lesions, and no white matter T2 hyperintensities. 123I-IMP SPECT and cardiac 123I-MIBG scintigraphy showed no specific abnormalities (Figure 1). Florbetapir F 18 PET was positive (Figure 1).
Case 2 images. (A,B) Brain magnetic resonance T1-weighted images showing slight diffuse brain atrophy. (C) N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography showing right-dominant hypoperfusion in the bilateral frontal, parietal, and temporal lobes. (D) Cardiac [123I]-metaiodobenzylguanidine scintigraphy. Heart-to-mediastinum ratios were 3.90 and 4.28 in early and delayed phases, respectively. The washout ratio was 26.0%. (E) Negative Florbetapir 18 positron emission tomography.
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F2
Right-dominant hypoperfusion in the frontal, parietal, and temporal lobes was observed on brain 123I-IMP SPECT, but cardiac 123I-MIBG scintigraphy results were normal (Figure 2). Florbetapir F 18 PET was also negative (Figure 2).