PMC6763666_01
(a) Cerebrospinal fluid (CSF) cytology of Giemsa- and Papanicolaou-stained cytospin preparations showing monoblasts/ promonocytes with round-to-folded nuclei, fine chromatin, and prominent nucleoli consistent for acute myeloid leukemia (AML) with monoblastic/monocytic morphology (Diff-Quik, x600). (b-e) Flow cytometry of the CSF using FACSDiva software using CD45 versus side scatter gating showing a large myeloid blast population (91% of all cells). The blasts were CD45dim, CD33+, CD34-, CD117-, and HLA-DRbright, consistent with central nervous system involvement by the patient's AML with monocytic differentiation. (f) Flow cytometry of bone marrow showing expression of monocytic markers (CD64 and CD11c) in the blast population.
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F1
Due to new-onset Bell's palsy, CSF specimens were obtained; pathology and flow cytometry reports were consistent with AML with CNS involvement, Figure 1.
(a) Preoperative computed tomography (CT) head showing bilateral subdural hematomas, (b) postoperative CT head, with bilateral subdural drains intact, (c) 3-week postoperative CT head, after daptomycin administration and removal of subdural drains.
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F2
He was found to have acute bilateral mixed-density SDHs measuring 8 mm on the left and 5 mm on the right in the setting of profound thrombocytopenia (platelet count = 7 K/microL), Figure 2.