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(A) and (B) Physical examination revealed a brown, moderately painful nodule of about 1 cm in diameter located deep in the umbilical fold, with signs of recent bleeding.
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Physical examination revealed a brown, moderately tender nodule of about 1 centimeter in diameter located deep in the umbilical fold (Fig. 1A and B).
A low power field showing a dermal glandular proliferation of endometrial-type glands surrounded by endometrial stroma (H&E stain: 200x). On the inset, a high power magnification highlighting typical morphologic features of endometriosis (H&E stain: 400x).
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On microscopic examination, histologic sections revealed a glandular proliferation of monolayered endometrial epithelium surrounded by a cytostroma with extravasated erytrocytes (Figs. 2-3A).
(A) Morphologic features of endometriosis. Endometrial stroma and glands embedded in dense fibroconnectival tissue. H&E stain: 400x. (B) Immunohistochemistry for CD10 showing strong cytoplasmic positivity in stromal cells. 400x. (C) Immunohistochemistry for estrogen receptors showing nuclear positivity in both epithelial and stromal cells. 400x. (D) Immunohistochemistry for progesterone receptors showing nuclear positivity in both epithelial and stromal cells. 400x.
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On microscopic examination, histologic sections revealed a glandular proliferation of monolayered endometrial epithelium surrounded by a cytostroma with extravasated erytrocytes (Figs. 2-3A). On immunohistochemistry findings, the epithelial and stromal cells too, showed a nuclear immunoreactivity for ER and PR (Fig. 3C and D); stromal cells expressed cytoplasmic positivity for CD10 (Fig. 3B).