PMC6344201_01
Dynamics of blast percentage, cytogenetic abnormalities, and mutational burdens through the course of therapy. Blast percentages observed by bone marrow morphologic evaluation are represented over time as blue shaded areas with blast populations defined by flow cytometry represented as dotted grey lines (B-ALL flow). Variant allele frequencies (VAFs) of somatic mutations are depicted over time for the EZH2 D185H variant in green and the EZH2 L71* in yellow. Frequency of cytogenetic abnormalities are represented as percentages based on the number of metaphases with the abnormality within the total number of evaluated metaphases. The current therapy received by the patient at a given time is specified under the X axis. BM cellularity = bone marrow cellularity, del(5q) = chromosome 5q deletion, mar = marker chromosome.
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F1
A detailed evolution of leukemic burden by morphology and flow cytometry, EZH2 VAF, and cytogenetic abnormalities is shown in Fig. 1.