PMC10018420_01
Low power view of the tumour showing necrosis centrally, with sheets of atypical trophoblasts to the left and normal background placental villi to the right.
cro-2023-0016-0001-529736_f1.jpg
PMC10018420_01_cro-2023-0016-0001-529736_f1.jpg
F1
Nests, irregular sheets, and tongues of atypical cells, including syncytiotrophoblast (ST), intermediate trophoblast (IT), and CT were present with disrupted villi seen focally in keeping with stromal invasion (shown in Fig. 1).
High power view of the tumour shows a triphasic cell population (a), with immunohistochemical stains for GATA-3 highlighting the cytotrophoblasts and intermediate trophoblasts (b), human chorionic gonadotrophin staining syncytiotrophoblasts (c), and human placental lactogen highlighting intermediate trophoblasts (d).
cro-2023-0016-0001-529736_f2.jpg
PMC10018420_01_cro-2023-0016-0001-529736_f2.jpg
F2
Immunohistochemistry confirmed trophoblastic lineage with positivity for GATA-3 (CT and IT), HCG (ST), and HPL (IT), supporting the diagnosis of choriocarcinoma (shown in Fig. 2, 3).
High power view of tumour illustrating the triphasic population of atypical trophoblasts.
cro-2023-0016-0001-529736_f3.jpg
PMC10018420_01_cro-2023-0016-0001-529736_f3.jpg
F3
Immunohistochemistry confirmed trophoblastic lineage with positivity for GATA-3 (CT and IT), HCG (ST), and HPL (IT), supporting the diagnosis of choriocarcinoma (shown in Fig. 2, 3).