PMC9714539_01
H&E image of the first case, with moderate-to-severe periappendiceal inflammation, involving the wall of perivisceral veins. This infiltrate showed relatively few CD68+ macrophages (C) and several CD3+ lymphocytes (D). Magnification 4x (B) and 20x (A).
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F1
Particularly, the visceral wall and perivisceral veins were infiltrated predominantly by CD3+ lymphocytes, with a minor amount of CD68+ macrophages (Figure 1).
PMC9714539_02
The second case showed mild inflammation, but with a perivascular involvement mostly by CD68+ macrophages (C), with very few CD3+ lymphocytes (D). Magnification 4x (B) and 20x (A).
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F2
The inflammatory infiltrates were dominated by CD68+ macrophages and CD3+ lymphocytes in equal distribution (Figure 2).
PMC9714539_03
The third case showed mild inflammation, with a scarcity of both perivascular CD68+ macrophages (C) and CD3+ lymphocytes (D). Magnification 4x (B) and 20x (A). A detail of the CD68+ macrophagic infiltrate around and within a large periappendiceal vein in case 2 (E).
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F3
Histological findings revealed mild transmural and perivascular inflammation with an inflammatory infiltrate mostly represented by CD68+ macrophages with very few CD3+ lymphocytes (Figure 3).