PMC9898807_01
a MRI (sagittal T1-weighted image with gadolinium) showing a contrast-enhanced solid cerebellar lesion. b MRI (axial T1-weighted image with gadolinium) showing leptomeningeal dissemination in cerebellum and left cerebellopontine angle (arrows). c Medulloblastoma of the histological defined classic form: poorly differentiated round and polyhedric embryonal cells with high mitotic activity (arrows) (H&E x40). d Immunoreactivity for neurofilament antibody (x40).
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F1
The patient, a 10-year-old girl, was referred to the pediatric neuro-oncology of the Portuguese Cancer Institute in Lisbon after a macroscopical total surgical resection of a cerebellar vermis tumor with leptomeningeal dissemination (shown in Fig. 1a, b) at the neurosurgery department of Lisbon Hospital Center (CHULN). The tumor was diagnosed at the neuropathology department of Lisbon Hospital Center (CHULN) as a medulloblastoma classical pattern (shown in Fig. 1c, d).