PMC3350055_01
Submucosal tumor with a central ulceration (arrow).
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fig1
At the cranial portion of the gastric corpus, a 5 cm, well-circumscribed reddish submucosal mass was observed (Figure 1).
Glomus tumor of the stomach in a 34-year-old woman: on a contrast-enhanced computer tomography scan, the mass is greatly enhanced (arrows).
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fig2
An abdominal CT scan confirmed the submucosal lesion which originated from the muscularis propria, measured 4.9 x 4.4 cm, and was compromising the longitudinal, muscular layers of the stomach that showed enhancement after the use of iodinated contrast (Figure 2).
(a) The mass localized on anterior gastric wall with exuberant vascularization on serous surface. (b) Vertical gastrectomy along the great curvature.
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fig3
The lesion infiltrated the gastric wall and compromised the serous layer where it was possible to observe large vascular proliferation (Figure 3(a)). We had chosen to perform a vertical gastrectomy removing part of the anterior and posterior walls of the stomach along the greater curvature (Figure 3(b)). 
(a) Sheets of glomus cells with eosinophilic cytoplasm distributed around dilated blood vessels with stasis (H.E. x1000). (b) Glomus tumor of the stomach. Positive staining for type IV Collagen (x1000).
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fig4
The cells contours were clear, and it was possible to identify dilated blood vessels among the cell blocks and areas of stromal hyalinization (Figure 4(a)). The immunohistochemical panel showed that the tumor cells were positive for smooth muscle actin and collagen type IV (Figure 4(b)) and negative for desmin, CD34, CD117, S-100 protein, creatin kinase, p53, chromogranin, and cytokeratins (Table 1).