PMC3278633_01
(A) Sonography showed small irregular hypoechoic lesion with angular margin and spiculations (arrows). (B) Mammography showed ill-defined hyperdense mass in left subareolar area which was adherent to areola. Nipple retraction, diffuse skin thickening, and multiple enlarged lymph nodes in left axilla were noted with shrinkage of volume of left breast. (C) Sonography showed irregular hypoechoic mass with invasion to nipple (arrows).
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F1
A 0.8-cm irregular, hypoechoic lesion near the left areola was demonstrated on sonography (Fig. 1A). On mammography, an ill-defined hyperdense mass occupied the left subareolar area which was adherent to the areola (Fig. 1B). An irregular hypoechoic mass with invasion to the nipple was demonstrated on sonography (Fig. 1C).
(A) Microscopic finding showed infiltrating nests of small cells in fibrotic stroma. Tumor cells had small hyperchromatic nuclei and scanty cytoplasms (H&E, x200). (B) Immunohistochemical stain showed strong positivity of tumor cells for neuron-specific enolase (x400).
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F2
Microscopic finding showed infiltrating nests of small cells in the fibrotic stroma, the tumor cells of which had small hyperchromatic nuclei and scanty cytoplasms (Fig. 2A). Immunohistochemical stain showed strong positivity of the tumor cells for neuron-specific enolase, suggestive of small cell neuroendocrine carcinoma (Fig. 2B).