PMC9372583_01
Patient timeline.
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F1
Given the progressive deterioration in HD symptoms, a 48-week "combined" metabolic strategy consisting of a time-restricted ketogenic diet (TRKD) was offered (Figure 1).
Problem-behaviors assessment:short form (PBA-s) outcomes at baseline, 24 weeks, and 48 weeks after commencing the time-restricted ketogenic diet (lower numbers indicate improved behavior).
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F2
Improvements were also measured in the PBA-s for apathy (which decreased from 12 to 3, representing a 75% improvement), disorientation (which decreased from 8 to 0, representing a 100% improvement), anger (which decreased from 6 to 3, representing a 50% improvement), and irritability (which decreased from 6 to 2, representing a 67% improvement) (Figure 2).
HD health-related Quality of Life (HDQoL) outcomes at baseline, 24 weeks, and 48 weeks after commencing the time-restricted ketogenic diet (higher numbers indicate improved quality of life).
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F3
With respect to quality of life, improvement was noted in mood-self (which increased from 52 to 65, representing a 25% improvement) (Figure 3).