PMC8214891_01
Microscopic image of liver showing patchy areas of necrosis (H&E; 20x in A and 40x in B).
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Microscopic examination showed hepatic congestion and geographical ischemic necrosis along with intracytoplasmic, canalicular and ductular cholestasis (Figure 1).
Yellow hyaline membrane disease. A - Gross image showing bilateral congested lungs with slight yellow discoloration; B - Microscopic image showing extensive intra-alveolar bilirubin pigment deposition. (H&E, 40x).
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Both lungs showed slight yellow discoloration and weighed appropriate to age (right: 40 grams, left: 28 grams) (Figure 2A). Microscopic examination showed congestion with extensive deposition of bright yellow pigment within the alveolar spaces (Figure 2B).
Kernicterus. A - Gross image of the brain with bilirubin pigment deposition in the fresh state; B - Gross image of coronal section of the brain with bilirubin pigment deposition in the basal ganglia, post-fixation.
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The brain was partially liquefied with extensive bright yellow bilirubin pigment deposition noted in the fresh state (Figure 3A). These pigments were noted most prominently in the basal ganglia and thalamus (Figure 3B) in addition to scattered portions of the brain, including the cerebellum, bilateral occipital lobes, and areas around the lumen of the fourth ventricle.
Microscopic image of the cerebral hemisphere showing extensive vacuolation, gliosis, numerous neurons with cytoplasmic eosinophilia and nuclear pyknosis, associated with yellow-orange cytoplasmic pigment deposition (H&E, 40x).
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Microscopic examination demonstrated marked distortion of the architecture of the cerebral hemispheres with vacuolation, severe gliosis and numerous neurons with cytoplasmic eosinophilia and nuclear pyknosis, associated with the presence of yellow-orange cytoplasmic pigment (Figure 4).