PMC3420693_01
Magnetic resonance imaging showing the enlargement of the liver and the nonhomogeneous lesion in segment VI.
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The magnetic resonance imaging showed a hepatomegaly and confirmed the lesion in segment VI (Figure 1), which showed features of a hepatocellular adenoma (HCA).
Histological features of hepatocellular carcinoma in a noncirrhotic liver. (a) Hepatocellular carcinoma with pseudoglandular pattern and bile production. (b) Loss of reticular fibres and cord thickening up to six cells. (c) Immunohistochemical staining for CD 34. (d) Positive immunohistochemical staining for glypican 3.
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In places, pseudoglandular tumor cell formations were seen (Figure 2(a)). The cords varied in thickness consisting of up to six cells, and a loss of reticular fibres could be demonstrated by silver staining (Figure 2(b)). The mitotic figure count was high with 2 to 6 mitoses per high power field (HPF = x400). The endothelium, which surrounded the trabeculae, showed a clearly positive immunohistochemical staining for CD 34 (Figure 2(c)). A weaker, cytoplasmatic staining was seen for glypican 3 (Figure 2(d)).