PMC3690236_01
(a) Large cobblestone papillae on upper lid, left eye. (b) Limbal mass with vascular fronds on its surface. (c) A close-up view of the limbal mass:note the areas of keratinisation present on inferior border of the mass. (d) Amniotic membrane covering the conjunctival defect after excision biopsy.
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PMC3690236_01_CRIM.OPHMED2013-527230.001.jpg
fig1
On eversion of the left upper lid, an intense papillary reaction was seen diffusely associated with several large "cobblestone" papillae measuring 1.5-2 mm in the centre and lateral side of the lid (Figure 1(a)). The temporal limbus in the left eye revealed the presence of a reddish sessile papillary mass extending for 2 hours from 2 to 4 o'clock (Figure 1(b)). The surface showed the presence of multiple capillary fronds appearing as red dots, with focal areas of keratinization on the inferior border of the lesion (Figure 1(c)).
Haematoxylin and eosin stain. (a) The surface is lined by stratified squamous epithelium showing pseudoepitheliomatous hyperplasia. (x100). (b) The lining epithelium does not show any dysplasia or malignancy (x200). (c) The subepithelium shows dense plasma-cell-rich inflammation (x400).
CRIM.OPHMED2013-527230.002.jpg
PMC3690236_01_CRIM.OPHMED2013-527230.002.jpg
fig2
Histopathological examination of the excisional biopsy specimen revealed that the surface was lined by stratified squamous epithelium showing pseudoepitheliomatous hyperplasia (Figure 2(a)). The lining epithelium did not show any evidence of dysplasia or malignancy while the subepithelium revealed a dense plasma-rich inflammation (Figures 2(b) and 2(c)).