PMC6383416_01
Infant's MRI results reveal periventricular leukomalacia in both the left (a) and right (b) sides of brain.
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fig1
The infant's MRI images revealed a bilateral periventricular leukomalacia (PVL) (Figure 1), with greater involvement of right than left parietal white matter. The red box in Figure 1 shows the MR voxel placement in the frontal white matter where brain metabolites were measured in this infant.
(a) Case infant's WM NAA/Cr ratio at TE = 270 ms and STEP scores versus infants with typical motor skill development. (b) Case infant's FA values in PLIC and STEP scores versus infants with typical motor skill development.
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fig2
This infant displayed a decreased NAA/Cr (Figure 2(a)), indicating a decreased frontal white matter neuronal and axonal integrity compared to other infants enrolled in the same early motor developmental study who had average motor developmental scores. In Figure 2(b), FA values in the posterior limb of the internal capsule (PLIC) are compared to STEP scores at 3 months.
Qualitative FA comparison of the case infant (high risk for motor delay) and peers (low risk for motor delays) based on STEP assessment scores.
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fig3
A qualitative comparison was completed using the case infant's FA values at the time of scan, and two infants in the study with typical motor scores on the STEP assessment who were at low risk for later motor delays (Figure 3).