PMC8107665_01
Timeline of cancer diagnoses and BRAF p.V600E mutation status.
10.1177_20363613211012929-fig1.jpg
PMC8107665_01_10.1177_20363613211012929-fig1.jpg
fig1-20363613211012929
The patient was a Caucasian male who developed eight different cancers between ages 57 and 64 years (Figure 1).
PMC8107665_02
PMC8107665_03
Cancers with BRAF p.V600E positive immunohistochemistry. (A); liver biopsy showing effacement of the liver tissue architecture by histiocytes ([H&E], 100x) that are staining positively for CD68 and BRAF. (B); skin biopsy showing infiltrative melanoma cells in the epidermis and dermis ([H&E], 100x), Melanoma cells stained positively for melanin A and BRAF. (C); left neck lymph node biopsy. Low magnification shows effacement of lymph node architecture by lymphoid infiltrate along with Langerhans histiocytic cells ([H&E], 100x) that are positive for Langerin and BRAF. (D); lung biopsy showing moderately differentiated adenocarcinoma ([H&E], 100x), these cells are positively stained for mucin and BRAF.
10.1177_20363613211012929-fig2.jpg
PMC8107665_04_10.1177_20363613211012929-fig2.jpg
fig2-20363613211012929
Excisional lymph node biopsy of the left neck confirmed LCH (Figure 2(c)). IHC stain for BRAF p.V600E was positive (Figure 2(d)).
PMC8107665_04
Cancers with BRAF p.V600E positive immunohistochemistry. (A); liver biopsy showing effacement of the liver tissue architecture by histiocytes ([H&E], 100x) that are staining positively for CD68 and BRAF. (B); skin biopsy showing infiltrative melanoma cells in the epidermis and dermis ([H&E], 100x), Melanoma cells stained positively for melanin A and BRAF. (C); left neck lymph node biopsy. Low magnification shows effacement of lymph node architecture by lymphoid infiltrate along with Langerhans histiocytic cells ([H&E], 100x) that are positive for Langerin and BRAF. (D); lung biopsy showing moderately differentiated adenocarcinoma ([H&E], 100x), these cells are positively stained for mucin and BRAF.
10.1177_20363613211012929-fig2.jpg
PMC8107665_04_10.1177_20363613211012929-fig2.jpg
fig2-20363613211012929
Excisional lymph node biopsy of the left neck confirmed LCH (Figure 2(c)). IHC stain for BRAF p.V600E was positive (Figure 2(d)).