PMC6582224_01
(a,b) White arrows in coronal fluid-attenuated inversion recovery (FLAIR) image (a) and axial T2-weighted image (b) show right temporal cavernous malformation (CM). Cortical atrophy and ventriculomegaly of the brain are also seen. (c,d) FLAIR images show total removal of the CM by a transcortical approach.
fneur-10-00620-g0001.jpg
PMC6582224_01_fneur-10-00620-g0001.jpg
F1
He had therefore visited a local hospital, where brain magnetic resonance imaging (MRI) had revealed CM in the right amygdala (Figure 1).
PMC6582224_02
(a) Intraoperatively, we place the four-contact subdural strip on the parahippocampal area. (b) Frequent, very small-amplitude spikes and spike-waves are seen, mostly from contact 1 (arrows) before removal of the cavernous malformation (CM). (c) Right after CM removal, these epileptiform discharges have disappeared.
fneur-10-00620-g0002.jpg
PMC6582224_02_fneur-10-00620-g0002.jpg
F2
Intraoperatively, the SE recording from the right parahippocampal area (Figure 2a) showed frequent epileptiform discharges (Figure 2b). After removal of the CM, the SE recording showed no interictal discharges (Figure 2c).
(a) Hematoxylin and eosin (HE) staining shows cavernous malformation. Eosinophilic nodules are considered to represent organized thrombi (blue arrow). (b) HE staining shows brain tissue with senile plaque (yellow arrow). (c) Periodic acid methenamine silver (PAM) staining shows two lesions of filamentous material (red arrows), comprising senile plaque. (d) Immunohistochemical staining shows immunoreactive senile plaque (arrow).
fneur-10-00620-g0003.jpg
PMC6582224_02_fneur-10-00620-g0003.jpg
F3