PMC2878684_01
Clinical picture.
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fig1
Physical examination demonstrated a 1 cm pearly, umbilicated papule with raised borders (Figure 1).
Microscopic appearance: raised papule with parakeratotic crust and acanthosis with thin epidermal strands extending deeply in the underlying dermis. The upper dermis is markedly edematous with marked capillary proliferation. The deeper dermal part of the lesion is composed of reactive lymphoid infiltrates.
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fig2
A biopsy (Figure 2) showed an asymmetrical nodule with parakeratotic crust and acanthosis with thin epidermal strands extending deeply in the underlying dermis.
One red intranuclear inclusion in the keratinocyte of the epidermis.
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fig3
One red intranuclear inclusion was identified in an epidermal keratinocyte (Figure 3).