PMC5516732_01
Conventional cerebral angiography revealed (a) M1 segments of the middle cerebral artery and (b) M2 segments of the middle cerebral artery with classic beading pattern of constrictions indicative of cerebral vasculitis (black arrows).
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fig1
A conventional angiography was performed and revealed diffuse cerebral vascular beading pattern of constriction involving vasculature of both hemispheres, a pattern indicative of diffuse vasculitis (Figure 1).
Histopathology of the cerebral cortex containing medium sized blood vessel. (a) H&E stain x40 reveals acute inflammation concentrated in vessel wall. (b) H&E stain x400 reveals acute necrotizing vasculitis; dense neutrophilic inflammatory exudate; and necrosis in vessel wall.
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fig2
An autopsy exam was performed, with brain tissue histopathology significant for scattered areas of vasculitis involving arterioles and numerous relatively recent infarcts (Figure 2).