PMC3459548_01
Warty exophytic SCC of the vulva (case 1).. Abbreviation: SCC, squamous cell carcinoma.
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A 41-year-old woman was seen in consultation for the combination of an asymptomatic hyperpigmented plaque type vulvar lesion on the right side and a painful exophytic nodule of the contralateral site arising from a larger flat leucoplakic lesion (Figure 1).
Histopathology of the vulvar squamous cell carcinoma (case 1): (A) Overview with epitheloid strands, cellular and nuclear atypias and formation of horn pearls (x4). (B) Multiple mitoses (x40). Hematoxylin-eosin stains.
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Histopathological examination of the nodule revealed an epithelial proliferation with the formation of horn pearls, keratinocytes with nuclear polymorphism, and increased mitotic activity (Figure 2).
PMC3459548_02
Condyloma-like exophytic growth of vulvar squamous cell carcinoma (case 2).
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A 44-year-old female presented with asymptomatic condyloma-like protrusions affecting labia majora and perineum and she noted > 2 years of slow enlargement (Figure 3).
Operation situs after debulking surgery (case 2).
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Surgery was performed for tumor debulking (Figure 4).