PMC7492959_01
Computed axial tomography of the abdomen with intravenous administration of iodinated contrast: centered on the lower two-thirds of the left kidney, neoformative mass with heterogeneous enhancement, and some areas of liquefaction with greater longitudinal anteroposterior and transversal axis evaluated as 10.5 x 11.7 x 8.5 cm, respectively.
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fig1
The abdominal computed tomography (CT) revealed on the left kidney, centered to the lower two-thirds, a neoformative mass with heterogeneous enhancement, and some areas of liquefaction, for which the greater dimensions were 10.5 x 11.7 x 8.5 cm longitudinal, anteroposterior, and transversal axis, respectively (Figure 1).
Colon biopsy. Fragment of mucosa from the distal portion of the intestine with conserved general architecture. Deposits of amyloid substance predominantly subepithelial and perivascular, positive for Congo red staining.
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fig2
The anatomopathological examination of colon biopsies revealed deposits of amyloid substance of predominant subepithelial and perivascular location (Figure 2), and immunohistochemical staining with antibodies specific for the major amyloid precursors (AA, immunoglobulin L chains of kappa or lambda type, antitransthyretin) showed positivity only for AA fibrils (Figure 3).
Colon biopsy. Immunohistochemical characterization of amyloid substance deposits, positive for AA amyloid.
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fig3
The anatomopathological examination of colon biopsies revealed deposits of amyloid substance of predominant subepithelial and perivascular location (Figure 2), and immunohistochemical staining with antibodies specific for the major amyloid precursors (AA, immunoglobulin L chains of kappa or lambda type, antitransthyretin) showed positivity only for AA fibrils (Figure 3).