PMC10263016_01
Ultrasound (US): 0.7cmx0.4cm and 0.6cmx0.4cm hyper echoes were detected in the direction of 12 o'clock in the right breast, both of which were adjacent to each other with clear borders and smooth margins and relatively uniform internal echogenicity. BI-RADS 3 (A); CDFI: There was no obvious blood flow signal (B).
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Ultrasound (US) showed that 0.7cmx0.4cm and 0.6cmx0.4cm hyper echoes were detected in the direction of 12 o'clock in the right breast, both of which were adjacent to each other with clear borders and smooth margins and relatively uniform internal echogenicity (Figure 1A and B).
Right longitudinal-oblique axis (MLO)(A) and cranial base (C-C) (B) mammography: round-like soft tissue nodules and foci of calcification with local unsmooth borders were seen in the upper right quadrant (arrows).
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No significant mass was seen in the left breast, and a round-like high-density shadow was seen in the right breast (Figure 2A and B).
Dynamic MRI: a nodular shadow was seen at the edge of the gland in the upper quadrant of the right breast, with a heterogeneous high signal in T2WI and persistent enhancement, which was approximately 0.6 cm x 1.0 cm in extent, with clear borders and irregular morphology (arrows) (A and B).
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T2WI and persistent enhancement, which was approximately 0.6 cm x 1.0 cm in extent, with clear borders and irregular morphology, and no obvious burr around it. Multiple foci of punctiform enhancement were also seen in both breasts (Figure 3A and B). The patient underwent excisional biopsy.
Pathological findings of low-grade ductal carcinoma in situ within a fibroadenoma of the breast (hematoxylin and eosin x100). (A and B) fibroadenoma of the breast with intra-ductal epithelial hyperplasia, partly monoclonal sieve-like hyperplasia with intraluminal calcification; (C) Positive immunohistochemical staining for CK5/6 in the myoepithelium with local expression deficiency; (D) Positive immunohistochemical staining for P63 in the myoepithelium with local expression deficiency; (E) Positive immunohistochemical staining for Calponin in the myoepithelium with local expression deficiency; (F) Positive immunohistochemical staining for C-erbB-2.
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Immunohistochemistry showed AR (3+, 90%), ER (3+, 90%), PR (3+, 85%), C-erbB-2 (2+), CK5/6 (+), P63 (+), Calponin (+) (Figure 4A-F).