PMC5726676_01
Violaceous tumor with greenish-colored nuances on the back
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f1
Physical examination showed violaceous nodules and tumors with some slightly greenish areas measuring 1 to 8cm on the trunk and limbs (Figures 1 and 2).
Violaceous tumor with greenishcolored nuances on the right upper limb
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f2
Physical examination showed violaceous nodules and tumors with some slightly greenish areas measuring 1 to 8cm on the trunk and limbs (Figures 1 and 2).
Histopathology: superficial and deep perivascular neutrophilic infiltrate
in the dermis and dense mixed infiltrate of neutrophils, lymphocytes,
and medium-size atypical round cells in the lobules and septa of adipose
tissue (Hematoxylin & eosin, X100)
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f3
C were negative. Bone marrow biopsy showed cellularity of 95% with predominance of granulocytes and their precursors, as well as megakaryocytic hyperplasia with hypo and hyperlobulated forms, compatible with chronic myeloproliferative disease. Cutaneous biopsy revealed normal-appearing epidermis, mild superficial and deep perivascular neutrophilic infiltrate in the dermis, and dense mixed infiltrate of neutrophils, lymphocytes, and medium-sized atypical round cells in the lobules and septa of adipose tissue, with surrounding megakaryocytes (Figure 3).
Immunohistochemistry positive for CD43 (X100)
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f4
The immunohistochemical study was positive for CD43, lysozyme, and myeloperoxidase, and proved to be negative for CD3, CD20, and CD30, confirming the diagnosis of myeloid sarcoma (Figures 4, 5 and 6).
Immunohistochemistry positive for lysozyme (X100)
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f5
The immunohistochemical study was positive for CD43, lysozyme, and myeloperoxidase, and proved to be negative for CD3, CD20, and CD30, confirming the diagnosis of myeloid sarcoma (Figures 4, 5 and 6).
Immunohistochemistry positive for myeloperoxidase (X100)
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f6
The immunohistochemical study was positive for CD43, lysozyme, and myeloperoxidase, and proved to be negative for CD3, CD20, and CD30, confirming the diagnosis of myeloid sarcoma (Figures 4, 5 and 6).