PMC4395824_01
Sarcoidosis. Inflammation comprising noncaseating epithelioid granulomas (asterisk, inset) and lymphocytes expands the tubulointerstitial compartment of the kidney and spares the glomerulus (mid-lower)
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F1
A renal biopsy was then performed demonstrating granulomatous interstitial nephritis and patchy interstitial fibrosis (fig. 1).
TINU. Mature lymphocytes and few eosinophils are noted in the mildly edematous interstitium; glomeruli are normal.
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F2
Biopsies from patients with TINU (fig. 2) infrequently demonstrate granulomas or multinucleated foreign body-type giant cells that can be associated with damaged tubules.