PMC4075914_01
Initial radiological findings. In A, chest X-ray showing a reticular
interstitial pattern predominantly in the lower lung fields, already denoting
some loss of volume. In B-E, CT scan showing septal thickening patterns,
traction bronchiectasis, small areas of ground-glass opacity, and consolidation
with a peribronchovascular distribution.
1806-3713-jbpneu-40-01-00092-gf01.jpg
PMC4075914_01_1806-3713-jbpneu-40-01-00092-gf01.jpg
f01
A CT scan of the chest showed calcified mediastinal adenopathy exhibiting an "eggshell" pattern, interlobular reticulation, traction bronchiectasis, and septal thickening, as well as areas of ground-glass opacity, alveolar consolidation with a peribronchovascular distribution, and areas of pleural thickening (Figure 1).
Photomicrographs of histological sections of surgical lung biopsy
specimens. In A, chronic inflammatory infiltrate and septal fibrosing reaction
(H&E; magnification, x40). In B, active fibroblastic foci (HHF35;
magnification, x100). In C, macrophages with anthracotic pigmentation and
birefringent silica particles, as well as multinucleated giant cells along the
bronchoalveolar axes and interlobular septa (HPX; magnification, x400). In D,
lymphocytic inflammatory infiltrate with T cells (CD3; magnification, x100). In
E, foci of B cells (CD20+) in the chronic inflammatory infiltrate (CD20;
magnification, x40). In F, predominance of T cells with a CD8 immunophenotype
(CD8; magnification, x200).
1806-3713-jbpneu-40-01-00092-gf02.jpg
PMC4075914_01_1806-3713-jbpneu-40-01-00092-gf02.jpg
f02