PMC7720070_01
Chest HRCT at 0, 6, 12, 18 and 36 months (mo): stability in size, shape and density of numerous small pulmonary nodules with a random distribution on the 4 first HRCTs, followed by a significant decrease in density of all pulmonary nodules at 36 months, i.e. 3 months after everolimus initiation (A). Similar observation focused on selected nodules in the right upper lobe (B) and left lower lobe (C). Follow-up of dimensions (long and short axis) in millimeters (mm) and density using Hounsfield Unit (HU) values of the 8 most easily perceptible solid nodules, showing no change in size over time before (first 4 HRCTs) and after (last HRCT) everolimus initiation, but a decrease in density on the last HRCT performed 3 months after treatment onset (D).
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fig1
A follow-up chest HRCT performed 3 months after everolimus initiation (and 3 years after the first thoracic imaging) showed a remarkable decrease in density of all pulmonary MMPH lesions, without obvious change in size (Fig. 1A-C). As shown in Fig. 1D, long and short axis (axial view) of all 8 nodules did not change over time either before or after everolimus therapy.