PMC7412926_01
The chronology of the major clinical findings.. The neurological, psychiatric status, the brain MRI findings, the major neuropsychological status and the administered medication are illustrated chronologically.. ACA, Addenbrooke Cognitive Assessment; mito, mitochondrial; MRI, magnetic resonance imaging; PANSS, Positive and Negative Syndrome Scale; suppl, supplements.
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Laboratory investigations detected anaemia, hyperglycaemia, hypoalbuminemia, hypokalaemia and elevated lactate, pancreatic and hepatic enzyme levels (Figure 1). The weight loss stopped and her cognitive functions started to improve (Figure 1). She seemed preoccupied, her gestures were poor and she showed no emotional reactions (Figure 1). The Mini Mental State exam score was 29/30 (Figure 1). ACA. After a half year of cariprazine treatment, her PANSS score dropped to 59 (Figure 1).
The follow up of the brain MRI.. (A, B) An MRI scan was performed in 2013 on a 1.5 T MR, almost absent mamillary bodies, and widened cerebellar sulci are visible. On (C, D), which were performed in 2018 on a 3 T MR, slightly more widened cerebellar sulci and the same atrophic mammillary.. MRI, magnetic resonance imaging.
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Brain MRI showed widened cerebellar sulci and almost absent mammillary bodies on T1 sequences (Figure 2A and B).