PMC8077539_01
Findings of chest radiography and computed tomography (CT). a Chest radiography before treatment with erlotinib revealing a mass shadow in the right upper lung field. b Chest CT before erlotinib treatment revealing a lung mass shadow in the right upper lobe. The mass shadow has lobulated margins. c Chest radiography 7 weeks after treatment with erlotinib. d Chest CT 7 weeks after treatment with erlotinib.
cro-0014-0599-g01.jpg
PMC8077539_01_cro-0014-0599-g01.jpg
F1
A 69-year-old Japanese woman visited our hospital with a right upper lung mass shadow on chest radiography (Fig. 1a) and computed tomography (CT; Fig. 1c). Chest radiography showed a mass shadow in the right upper lung field, which decreased remarkably in size after erlotinib treatment (Fig. 1c). Chest CT also showed a reduction in the size of the lung mass in the right upper lobe (Fig. 1d).
Skin features and pathological findings at skin biopsy. a Macroscopic findings of the abdominal skin. Diffuse edematous erythema and scattered small pustules are observed. b Close-up findings of the skin. c, d Microscopic findings of a skin lesion showing intraepidermal pustules with inflammatory cell infiltration. Hematoxylin and eosin stain, x40 (c), x100 (d).
cro-0014-0599-g02.jpg
PMC8077539_01_cro-0014-0599-g02.jpg
F2
Multiple pustules and purpura were found on the skin of her abdomen, lower back, hips, and thighs (Fig. 2a, b). Histological examination of a skin biopsy specimen showed intraepidermal pustules with neutrophil and eosinophil infiltration (Fig. 2c, d).