PMC9871411_01
Ultrasonography of small cell neuroendocrine carcinoma of the ureter. (A) Transabdominal ultrasonography showed a hypoechoic mass located in the lower ureter (arrow) that was uniform on internal echo with an undefined boundary. (B) Transrectal ultrasonography showed that the blood flow of the mass was abundant (arrow), and the ureter wall around it was abnormal.
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Transrectal ultrasonography was performed; a thickened lower ureter wall, whose structure was disordered and stiff, and additional details of the mass were obtained (Figure 1).
Computed tomography of small cell neuroendocrine carcinoma of the ureter. (A) Plain computed tomography scan showed a soft tissue mass of the lower ureter that was heterogeneous and well-defined, which grew into the bladder cavity (arrow). (B) Enhanced computed tomography showed the soft tissue mass of the lower ureter that was slightly inhomogeneous enhancement (arrow).
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Two days ago, abdominal computed tomography (CT) explored a soft tissue mass of the lower ureter that should be distinguished from tumors in other hospitals (Figure 2).
Magnetic resonance urography of small cell neuroendocrine carcinoma of the ureter. (A) The transverse section showed a mass that occurred in the left ureter (arrow). (B) The sagittal section showed the upper edge of the mass was cup-shaped (arrow).
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Furthermore, magnetic resonance urography (MRU) suggested that the ureteral mass had a low signal filling defect, which was considered a carcinoma due to the lymph nodes being scattered around it (Figure 3).
Pathology of small cell neuroendocrine carcinoma of the ureter. (A) Hematoxylin-eosin staining exposed the cells proliferated in a nest shape and grew infiltratively with obvious atypia, the nuclei of which were large and deeply stained. (B) Immunohistochemical staining findings were CD56-positive, Syn-positive, CK-partially positive, TTF-1 partially positive, CK20-negative, GATA3-negative, CgA-negative, and Ki-67 approximately 70% positive.
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Finally, pathological examination performed confirmed small cell neuroendocrine carcinoma (SCNEC) (Figure 4).