PMC5745655_01
Relationship between gabapentin dose and anxiety. Anxiety was assessed on a 0-10 scale; GAD-7 scores are added where available. Day 0 is the day of discharge from the last hospitalization. Gabapentin is expressed in total daily doses. Measurements were not continuous, but for clarity lines connect the values obtained during in-office follow-up appointments or telephone conversations (a total of 27 measurements in 294 days).
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fig1
On day 18 after discharge, she attempted a self-initiated gabapentin taper due to improved anxiety and perceived "drowsiness" (see Figure 1 for graphical depiction of anxiety-gabapentin dose relationship over time). On day 48 following discharge, one month after her first self-initiated dose reduction, her gabapentin was again increased to 300 mg TID with immediate and pronounced decrease in anxiety (Figure 1). This change was again accompanied by increased anxiety within days, and 19 days after the last dose reduction, her gabapentin was returned to 300 mg BID with immediate improvement in anxiety (Figure 1). As per her request, her dose was increased to 300 mg BID on day 149, followed by a decrease in her anxious symptoms within 24 hours (Figure 1).