PMC6694773_01
Skin purpura and kidney biopsy. A, Lower extremity purpura. B, Hematoxylin and eosin stain showing glomerular necrosis (x400). C, Periodic Schiff-Methenamine stain showing proliferation of mesangial cell and mesangial matrix (x400). D, Positive staining with kappa-light chain in the glomeruli and renal tubular epithelial cells (x400). E, Confluent, granular staining of mesangial IgA deposits (x400). F, Electron microscopy demonstrating the electron-dense deposits in the mesangial region (x5000). Scale bars in B, C, D, E: 50 mum; scale bar in F: 2 mum.
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The patient underwent a kidney biopsy in November 2017 that revealed HSP nephritis (HSPN, ISKD classified as type III, defined as focal hyperplasia and sclerosis), with isolated positive kappa-light chain and negative lambda light chain immunostaining (Figure 1).
Hematoxylin and eosin stain showing chronic inflammatory cell infiltration around small blood vessels (A, x200) and fibrous connective tissue hyperplasia (B, x400). Scale bars: 100 mum (A) and 50 mum (B).
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