PMC4531975_01
Histologic findings of lymph node show large pleomorphic tumor cells with irregular nuclear profiles and abundant dense cytoplasm (H & E stain, x400).
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A year prior to admission, he had had a history of enlargement of both cervical lymph nodes and postprandial epigastric pain, which was diagnosed to be early gastric cancer, Ki-1-positive anaplastic lymphoma, stage IIIB involving right submandibular lymph nodes, left cervical lymph nodes and hepatoduodenal lymph nodes (Fig. 1) without bone marrow involvement.
Photograpy shows multiple pin head sized erythematous papules on anterior chest wall (Arrow heads).
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There were multiple small sized papulonodular eruptions on the anterior chest wall (Fig. 2).
Skin biopsy shows the dermis diffusely infiltrated with large pleomorphic tumor cells seen in lymph node (H & E stain, x200).
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Light microscopic examination of skin specimen showed that the dermis was diffusely infiltrated with large pleomorphic tumor cells, which were strongly positive for Ki-1 immunohistochemical stain (Fig. 3, 4).
Tumor cells are strongly positive for Ki-1(immunohistochemical stain, x200).
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Light microscopic examination of skin specimen showed that the dermis was diffusely infiltrated with large pleomorphic tumor cells, which were strongly positive for Ki-1 immunohistochemical stain (Fig. 3, 4).
Electromicroscopy shows that the tumor cell has convoluted nuclei with prominent nucleoli and sparse intracytoplasmic organelles.
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Electromicroscopic examination revealed convoluted nuclei with prominent nuclei and sparse intracytoplasmic organelles (Fig. 5).