PMC4404974_01
The pathophysiology of bradykinin formation via the contact pathway.. Notes: Functioning C1-INH inhibits the formation of bradykinin. ACE inhibitors impair the degradation of bradykinin.. Abbreviations: ACE, angiotensin-converting enzyme; C1-INH, C1-inhibitor; fXII, factor XII; HMWK, high-molecular-weight kininogen.
jbm-6-115Fig1.jpg
PMC4404974_01_jbm-6-115Fig1.jpg
f1-jbm-6-115
ACE inhibitor-associated angioedema is thought to be secondary to impaired degradation of bradykinin (Figure 1).
PMC4404974_02