PMC7662390_01
The pump (Lenus Pro , 20 ml) implanted in the left hypochondria for intravenous treprostinil delivery (patient 1).
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F1
The patient being reluctant to IV access with external pump an implantable pump was proposed (LenusPro  20 ml, Figure 1).
Treprostinil delivery flow rate by the LenusPro  pump for patient 1 (black) and patient 2 (white) expressed relative to the expected calibrated flow. For patient 1, a catheter thrombosis resulted in a dramatic flow decrease that was treated by a standard repermeabilization procedure (black arrow). Horizontal lines represent the +-10% accepted flow error. The red dot represents the ex-vivo flow rate of the withdrawn pump determined in experimental condition by refilling it with a 20 ml saline solution.
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F2
As with the first case we observed a progressive increase in treprostinil flow reaching 1.52 ml/day which is a 20% increase over the calibrated value of 1.27 ml/day (+- 10%) (Figure 2).
PMC7662390_02
Treprostinil delivery flow rate by the LenusPro  pump for patient 1 (black) and patient 2 (white) expressed relative to the expected calibrated flow. For patient 1, a catheter thrombosis resulted in a dramatic flow decrease that was treated by a standard repermeabilization procedure (black arrow). Horizontal lines represent the +-10% accepted flow error. The red dot represents the ex-vivo flow rate of the withdrawn pump determined in experimental condition by refilling it with a 20 ml saline solution.
fmed-07-539707-g0002.jpg
PMC7662390_02_fmed-07-539707-g0002.jpg
F2
As with the first case we observed a progressive increase in treprostinil flow reaching 1.52 ml/day which is a 20% increase over the calibrated value of 1.27 ml/day (+- 10%) (Figure 2).