Background:
The sequential occurrence of the 2 malignancies development of nasopharyngeal carcinoma (NPC) and lymphoma is extremely rare and their coexistence raises the question of a common etiologic factor.
Clinical findings/clinical concerns:
A 71-year-old previously healthy man presented with diffuse large B-cell lymphoma (BCL) followed by NPC almost 2 years later with Epstein-Barr virus (EBV) positive.
Diagnosis:
Endoscopic examination characterized a fixed, hard and nontender mass in the nasopharynx and biopsies were done.
Intervention:
A patient successfully underwent chemotherapy for lymphoma and chemoradiation for carcinoma sequentially.
Outcomes:
He was followed up every 3 months for 1 year with endoscopic and radiological examinations. The nasopharynx mass was completely resolved after chemoradiation therapy.
Conclusion:
The presentation with diffuse large B-cell lymphoma (BCL) and NPC in this patient was perhaps caused by dual EBV infection or a different oncogenic mechanism.