Background: Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of end-stage renal disease (ESRD) and may pose significant technical challenges for kidney transplantation. Recently, robot-assisted kidney transplantation (RAKT) has been shown to achieve excellent patient and graft outcomes while reducing surgical morbidity. However, the vast majority of RAKT performed so far were from living donors and no studies reported the outcomes of RAKT in patients with ADPKD. Case Presentation: Herein, we describe the first successful case of RAKT from a brain-dead deceased donor in a 37-year-old patient with ESRD due to ADPKD. Conclusion: Our case highlights that RAKT can be safely performed by experienced robotic surgeons even in selected complex recipients such as patients with ADPKD and using grafts from deceased donors.