Severe forms of attrition are frequently found in patients with no or insufficient posterior occlusal support. Management of such patients using fixed or removable prostheses is a complex procedure and is still a challenge for clinicians. The present clinical report describes step by step full mouth rehabilitation of a patient with severely worn dentition using computer-aided design/computer-aided manufacturing- (CAD/CAM-) generated wax patterns, milled zirconia frameworks, and fabrication of removable partial denture (RPD) abutments using a digital-conventional method. The results were satisfactory during 18 months of follow-up.