Kefir (a traditional collection of beneficial microbes) is a popular accepted beverage that usually consumed for its health-promoting effects in Iran and Caucasian regions. In this case, the beneficial effects of a kind of kefir were reported on glycated hemoglobin A (HbA1c) level, and weight loss of an indexed diabetic mellitus patient. The patient as a supplement of her routine anti-diabetic drugs consumed Probiotic kefir. After 90 days of consumption the patient, have about 4 kg weight loss, and her HbA1c decreased from 7.9 to 7.1. Depth of sleep and energizing effects of kefir was also from very remarkable findings of this case, as reported by the patient.