A granuloma is a collection of epithelioid histiocytes that is often associated with multinucleated giant cells, and is considered widely to be a non-neoplastic lesion, although some lesions demonstrate aggressive behavior similar to that of a neoplasm. The diagnosis of giant cell granulomas (central and peripheral) is confirmed by histopathologic examination. Early detection and excision are important to minimize potential dentoalveolar complications. The following article consists of case reports of central and peripheral giant cell granuloma (PGCG), and discussion about the diagnosis and management of such lesions. How to cite this article: Mukherjee CG, Mukherjee U, Bansal A, Mukhopadhyay M. Giant Cell Granuloma: Two Expressions in Pediatric Population. Int J Clin Pediatr Dent 2018;11(1):46-49.