Superior mesenteric artery syndrome (SMAS) is a rare, debilitating clinical condition caused by compression of the third portion of the duodenum by the superior mesenteric artery. Common symptoms include intermittent postprandial abdominal pain, nausea, weight loss, and bilious vomiting. Here we present a case series of three patients with SMAS who were treated with laparoscopic duodenojejunostomy. Patients were females between 12-17 years old. All patients underwent a successful laparoscopic duodenojejunostomy after diagnosis. Mean time to feedings after surgery was 4.00±1.15 days (mean ± SD) and length of stay was 8.6±2.7 days. SMAS remains a complex disease to diagnose and treat. Here we demonstrate that laparoscopic treatment of SMAS is a safe surgical treatment option, and is associated with earlier initiation of enteral feeds and a shorter hospital stay after surgery when compared to medical treatment. This is a safe, effective, and relatively simple procedure for the experienced minimally invasive surgeon [1].