This paper reports the technique and outcome of femtosecond laser-assisted cataract surgery (FLACS) in an iris coloboma patient (59-year-old male patient) with bilateral grade 3 cataractous lens and a shallow anterior chamber. Best-corrected visual acuity (BCVA) was 0 on logMAR with spherical equivalent (SE) 9 D in the right eye, and BCVA of 0.3 logMAR with a SE 8.75 D in the left. FLACS was performed on the left then the right eye using the Catalys platform of Johnson & Johnson (intraocular lens implantation of AMO Tecnis 1 ZCB00). Customized parameters were constructed to create capsulotomies of 4.54.7 mm for the left and right eyes, respectively, with manual centration of the distorted pupils. On the second day of follow-up, left-eye BCVA was 0.5 with SE 1 D, and right-eye BCVA was 1 with SE -0.75 D. At the 1-year follow-up, eyes showed stable bilateral Tecnis 1 IOL and refraction. FLACS is a safe surgical option with stable outcomes in cases of cataract with iris coloboma.