Objective:
Familial Urothelial cell bladder cancer is rare. We report two families with urothelial cell carcinoma (UCC) of bladder with family history in other relatives, displaying probable autosomal dominant inheritance and a late onset pure UCC phenotype, and document the phenotype in each family.
Methods:
Descriptive familial study on two pedigrees over three generations.
Results:
Two families with UCC bladder were identified, and the phenotype documented, each family having three cases of late onset UCC.
Conclusion:
Some cases of UCC are hereditary and may display autosomal dominant inheritance with late onset of the cancer. Clinicians should be aware of the existence of a familial late onset UCC phenotype when managing cases of UCC.