Infective endocarditis remains a dreaded and severe disease because of its course, its complications, its need for good antibiotic management, as well as its morbidity. Peripheral mycotic aneurysm is a rare complication of infective endocarditis. We report the case of a 62-year-old female patient who presented with Streptococcus SPP infective endocarditis treated by antibiotics. Two months later, she presented with a mycotic aneurysm of the right brachial artery with the same germ, we have performed a brachial artery ligation, then a complete revascularization by graft of the saphenous vein. Through this case, we should not forget that the lesional assessment is always necessary to avoid missing serious complications that could threaten the functional prognosis, even vital.