Psoriasis is one among the wide-spreading, chronic, frequently recurring diseases of the skin. Its world prevalence varies between 0.09% and 11.4% in 2013 which reported in 2006 as in between 0.5% and 4.6%. In Ayurveda, the description of Kushta-roga viz. Vata-Kaphaja kushta finds similarity with psoriasis. The common sites of occurrence of psoriasis are scalp, elbow, knee, earlobes and sole which are also considered as the location of Vata and Kapha. The science of Ayurveda has anecdotal accounts of success in the management of psoriasis in the actual clinical practice even though it lacks the evidence-based medical dermatology research data. It observed that the physicians adopt several treatment protocols for the cure of this disease in clinical practice, which was not rigorously evaluating in research settings. This paper/report is one of on the 'Thuvaraka rasayana' is one such component that could improve treatment outcomes in Psoriasis. A pre and post test case report selected of a 36-year-old lady patient who diagnosed as having stable psoriasis vulgaris for last seven years. She was administered with internal and external therapies along with Shodhana therapies (bio-cleansing procedures) and then followed by intake of Thuvaraka rasayana. The total duration of the treatment was 43 days, and the Study subject assessed before treatment, after treatment and on follow-up for improvement using PASI scoring, and histo-pathological study. All the symptoms observed in the beginning were found considerably reduced, and the severity also found mild. On the follow-up, it concluded that the lesions disappeared completely and the skin set back to its normal texture. Even though psoriasis is an autoimmune disease where recurrence rate found more Shodhana therapy and Thuvaraka rasayana have a definite role.