The current management of neoplastic obstruction, SVC, and brachiocephalic vein thrombosis, especially of SVC, is based on the combined use of interventional (endovascular thrombolysis or thrombectomy, stent placement) and noninterventional (radiation, chemotherapy) means of treatment. We present the case of a forty-year-old woman with SVC and left brachiocephalic vein thrombosis secondary to lymph node metastasis of non-small-cell lung cancer. A combination of rheolytic thrombectomy (Angiojet device) and stent placement was performed for both venous sites with complete technical success. We discuss the principles of percutaneous rheolytic thrombectomy, its effectiveness, and potential complications.