Reiter syndrome is an autoimmune condition that develops in as a reactive response to GI or GU related infectious and rarely related to Intravesical BCG. it is a triad of conjunctivitis, urethritis, and arthritis. Here we report the case of a female patient who developed acute Reiter's syndrome following intravesical Bacillus Calmette-Guerin (BCG) immunotherapy for superficial bladder cancer. After the sixth dose in the maintenance phase of treatment the patient developed conjunctivitis, aseptic urethritis, and polyarthritis consistent with a diagnosis of Reiter's syndrome. In this patient non-steroidal anti-inflammatory drugs (NSAIDs), oral steroids and anti-tuberculosis drugs were administered with complete resolution of symptoms.