Latex allergy is a critical occupational health problem in healthcare settings. Exposure to latex can lead to severe allergic reactions, including anaphylaxis. However, in epidemiological studies, occupational anaphylaxis due to natural rubber latex is relatively rare. For this reason, allergic reactions from latex exposure in the workplace may not be well aware and, therefore, lead to delayed appropriate management. We reported a female physician who sought occupational health program counseling for her latex allergic reaction following occupational exposure and her two episodes of latex anaphylaxis during medical-surgical procedures. An occupational health management program (e.g. glove replacement and a bracelet with latex allergy labeling) was established. After the intervention, she rarely experienced any allergic symptoms. Given these points, anaphylaxis can be triggered by occupational exposure to latex; thus, occupational health management is key to preventing and managing latex allergies in the workplace.