Myospherulosis is a rare and recently discovered disease apparently caused by the placement of mineral oil, petrolatum-based products or haemostatic agent into different tissues. It can mimic various pathological conditions in different tissues of the body. A sixty year old man presented with left sciatica and a gluteal mass. Imaging showed a retroperitoneal mass extending in gluteal region through the left ileum. Preoperative Fine Needle Aspiration Cytology (FNAC) reported as schwannoma. Patient was managed surgically. Histopathology confirmed myospherulosis. To the author's knowledge, this is the first report of myospherulosis that involved retroperitoneal space and gluteal region through the ileum. In this case presentation clinical features, investigations and surgical management will be discussed.