Remote patient monitoring (RPM) is increasingly more accessible and accurate. The optimal utilization of RPM requires medical conditions which have predictive physiologic changes and effective outpatient therapies. Respiratory rate elevation has been shown to be predictive of impending chronic obstructive pulmonary disease (COPD) exacerbation and treatment often focuses on home-based medical therapies. In this case, we report the successful treatment of a patient with an exacerbation of COPD based on pre-identification via respiratory RPM.