Corynebacterium bovis is a mainly zoonotic pathogen, a common cause of bovine mastitis. It is however rarely pathogenic in humans, with only few cases reported in the literature. We present the first reported case of neurosurgical site infection due to c.bovis, resulting in a brain abscess. A 75-year-old female presented with dysphasia resulting from lung metastases. She underwent surgical resection, and four months later presented with swelling, tenderness and crusted exudate over the surgical site. Mri revealed surgical site infection and brain abscess, therefore the patient underwent urgent surgery. C.bovis was isolated from all specimens sent from different locations. The patient received appropriate antibiotic treatment without sequela. C. Bovis is being increasingly reported as a cause of various human infections, and should not automatically be considered to be a mere contaminant. It is imperative to be certain, prior to the antibiotics treatment, that this particular isolate is likely to be the pathogen, as it can be evident when there are multiple positive cultures of this pathogen from several locations.