Chronic migraine is common but difficult to treat. Most patients respond poorly to drugs. Occipital nerve block such as stellate ganglion block is an effective treatment without continuous effect for migraine. Pulsed radiofrequency (PRF) technique has been shown to be effective in relieving headache and prolonging the effect of nerve block. This case report is about a patient who suffered from chronic migraine with occipital pain and was successfully treated with PRF of C2 (axis) dorsal root ganglion (DRG) under ultrasound guidance confirmed by computed tomograpy scan. The patient did not feel headache after 1-year follow-up. This suggests that C2 DRG PRF might be considered as an alternative treatment for chronic migraine with occipital pain.