Hot flashes are a primary reason for medical visits during menopause. They can interfere with sleep, cause mood disturbances, decrease the overall quality of life, and are associated with significant health care and societal costs. This case report examines the safety and effectiveness of Lepidium peruvianum (maca) for the management of menopausal-related symptoms. A 32-year-old White female presented with hot flashes, night sweats, anxiety, and mood changes following a hysterectomy and oophorectomy. She was provided with a personalized nutrition plan, Lepidium peruvianum (maca), targeted nutrient supplementation, and lifestyle recommendations. These interventions resulted in the safe and effective resolution of hot flashes and anxiety in 2 months and significantly improved her moods and sleep. This case report demonstrated that the use of Lepidium peruvianum, in conjunction with dietary and targeted supplement modifications, appeared to be safe and resulted in the rapid improvements and resolution of symptoms associated with menopause.