Hydatid cyst is endemic in central parts of India, caused by infection with Echinococcus granulosus larva leading to development of cysts. Liver is most commonly involved organ. Isolated splenic hydatidosis is a very rare entity and only small clinical series or case reports have addressed the issue of splenic echinococcosis. We, hereby, present a case of an isolated giant hydatid cyst in spleen of a 30-year-old lady. Splenectomy was done and the diagnosis was confirmed on histopathological examination. Thus, a hydatid cyst should be kept in mind in the differential diagnosis of cystic lesions of spleen.