Central venous catheter is a commonly performed procedure in which inadvertent arterial puncture is a known complication. Inadvertent arterial injury with a large-bore catheter is associated with significant morbidity and there are a few endovascular techniques to repair the injury, including the use of a percutaneous closure device and a covered stent placement. We report a case of a patient with complex medical history complicated by inadvertent right subclavian artery injury during central venous catheter insertion. The catheter was immediately removed. The right subclavian arterial injury was repaired with a stent-graft.