Merkel cell carcinoma (MCC) is a rare cutaneous growth with aggressive nature. It mostly affects on the head and neck of white men aged 65 years old and immunosuppressed patients. Limited cases were reported in Asian patients. Loco-regional metastases with the regional lymph nodes involvement were common. The treatment methods include complete surgical excision and radiotherapy. Topical imiquimod and biologics are promising therapies. Here, we present a case of MCC occurring in a 76-year-old Chinese woman.