A 23-year-old female with a past medical history of gastroesophageal reflux disease presented with shortness of breath induced by exercise and certain odors. She reported the symptoms of autonomic dysfunction including fatigue, chest pain, lightheadedness, headaches, numbness/tingling in the arms and legs, and exercise intolerance. Vital signs were significant for orthostatic intolerance. Volume flow loop in the pulmonary function tests showed a flattening of the inspiratory portion characteristic of vocal cord dysfunction. Laryngoscopy showed dyskinesia of the left vocal cord, especially after exercise. Multifactorial approach was used including increased fluid intake and breathing exercises. After 6 weeks of breathing and isometric exercises, the patient reported improvement in dyspnea after exercise. This case report demonstrates the therapeutic role of breathing and isometric exercises in the management of vocal cord and autonomic dysfunction.