Young children with hypodontia caused by hypohidrotic ectodermal dysplasia (HED) not only have difficulties in mastication and speech but can also sense that their appearance is different from others. Enabling children with HED to look like their peers through the use of well-fitting and functioning complete and removable partial dentures with age appropriate teeth will greatly assist in their transitioning in to their school years and add to their psychological well-being. Although denture construction requires multiple patient appointments and good co-operation, dentist also should educate and encourage parents and patient to tackle the difficulties that may come across during denture construction. In this present case the child, a 4-year-old, required a complete denture in the lower arch and removable partial denture in upper arch to achieve functionality and enhanced esthetics. How to cite this article: Trivedi BD, Bhatia R. Complete and Removable Partial Prosthesis for a Child with Hypohidrotic Ectodermal Dysplasia. Int J Clin Pediatr Dent 2013;6(1):71-74.