Background: Pancreatic cancer is an aggressive and malignant disease that usually presents as an isodense or hypodense lesion with no significant enhancement in contrast CT. CT scan plays an important role in the diagnosis of pancreatic diseases, especially in pancreatic cancer and pancreatic neuroendocrine tumors. Presentation: This report includes a case of a 53-year-old female patient presenting a high-density mass in the pancreas on contrast CT. The mass was surgically removed, and the pathology confirmed the diagnosis of pancreatic adenocarcinoma. Conclusion: Sometimes the contrast CT of pancreatic cancer can be expressed as high density, which is similar to pancreatic neuroendocrine tumors. It is necessary for us to identify carefully.