Studies have focused on the efficacy of transtheoretical model in the management of substance dependence, but not much have focused on the changes with respect to the patient's mood, life skills, and interpersonal relationship issues that take place during the therapy. The present study explores a case by using motivational interviewing and relapse prevention strategies to qualitatively record the applicability of the transtheoretical model in terms of readiness to change, action taken, relationship conflicts, assertiveness, and depression in an individual with alcohol dependence. The intervention was carried out over 3 months for ten sessions followed by follow-up for 8 months. The results indicated improvement in the patient in the dimensions of level of action taken for increasing abstinence period, decreasing the level of depression, enhancing readiness to change, and improving assertiveness and improvement in marital adjustment with spouse, which were observed and reported during the post follow-up sessions.