Pericardial cysts are rare congenital abnormalities with a reported incidence rate of 1/100,000 males. The most common locations of these cysts are middle mediastinum and right cardiophrenic angle. Pericardial cysts are usually asymptomatic unless a complication or rapid growth occurs. Diagnosis is generally made incidentally or using combined radiological X-ray, contrast Computed Tomography (CT), and echocardiography imaging. Various forms of treatments include observation, needle aspiration, and surgical excision of the cysts. Recurrence of the disease is common when aspiration approach is selected. Herein, we present a case of pericardial cyst affecting right cardiophrenic angle in a 36 year-old man with an atypical right chest pain and chronic cough. Finally, the patient was treated successfully using surgical approach.