The hand is an integral part of our body. Any deviation in hand anatomy not only affects the day-to-day function but it even results in unesthetic appearance. Rehabilitation of these deformities is done either by microsurgery or with the help of silicone prosthesis. Nonsurgical treatment was carried out, where rehabilitation of the first digit was done with customized silicone prosthesis. Replacement of these deformities with silicone prosthesis is usually done by prosthetist. However, we being an oral and maxillofacial prosthodontist, replacement of these missing complete or partial fingers, thumb, ear, and nose is also done by prosthodontist. Rehabilitation of these deformities with silicone prosthesis can offer psychological, functional, and esthetic advantages. Recent advances in materials and skill of an individual made it possible to fabricate esthetically pleasing prosthesis. Mini implants are widely used for retaining silicone prosthesis; however, they are expensive and need surgical intervention. Vacuum-retained silicone-retained silicone prosthesis is a good and minimal invasive option for these patients. This clinical report describes a straightforward technique for fabricating silicone thumb prosthesis for a patient with amputated thumb.