Pancreatic squamous cell cancer (PSCC) is a rare and aggressive form of pancreatic cancer that has a poor prognosis. The 5-year survival rate for PSCC is estimated to be approximately 10%, and the median overall survival time is 6 to 12 months. Treatment options for PSCC include surgery, chemotherapy, and radiation therapy, but the outcomes are usually not very favorable. The outcomes depend on the stage of the cancer and the patient's overall health and response to treatment. The optimal management remains early diagnosis and surgical resection. We present a rare case of PSCC with spleen invasion, which arises from a large cyst with eggshell calcification, the patient was treated by surgical resection of the tumor and adjuvant chemotherapy. This case report emphasizes the necessity of regular follow for pancreatic cyst.