Anti-Ma2 associated paraneoplastic syndrome usually presents as limbic encephalitis in association with testicular tumours., Only four patients have been reported with involvement outside the CNS, two of whom also had limbic or brainstem encephalitis., We report a man with anti- Ma2 associated myeloradiculopathy and previous testicular cancer whose neurological syndrome stabilised and anti-Ma2 titres fell following orchidectomy of a microscopically normal testis.