Postpartum methicillin-resistant Staphylococcus aureus (MRSA) infection occurs in patients with complicated vaginal delivery or cesarean section. The infection can manifest as mastitis, endometritis, and if untreated may lead to toxic shock syndrome. We report a case of postpartum MRSA osteomyelitis diagnosed by 99mtechnetium-methylene diphosphonate skeletal scintigraphy and single-photon emission computed tomography-computed tomography (CT) that was further confirmed by magnetic resonance imaging and CT-guided biopsy. This multimodal imaging approach helped reach the diagnosis and in further management of the patient.