Takotsubo cardiomyopathy (TTC) may clinically mimic an acute coronary syndrome and is most often associated with an acute stressor. In this case report, we describe an atypical case of TTC triggered by multiple subacute stressors rather than 1 acute stressor. We also report TTC and transient global amnesia occurring concurrently. This case highlights that TTC can present without a typical stressor and should nonetheless by considered in the appropriate clinical context. Concomitant presentation with transient global amnesia is uncommon, but may result from the 2 conditions potentially sharing an underlying etiology.