Ameloblastomas with multiple histologic variants are rare odontogenic neoplasm of mandible and maxilla, and have high recurrence rates if improperly treated. They are histologically benign, slow growing, and invasive tumors. These tumors are asymptomatic in nature, unless they attain a large size to cause expansion and perforation of adjacent tissues, for which patient might seek treatment. Due to their aggressive nature and high recurrence rate, treatment remains a matter of debate. Complete excision of lesion with least morbidity would be the therapeutic challenge. However, there is an increased risk of recurrence due to local treatment. Here in, we present a large multicystic recurrent ameloblastoma on right-body-ramus region of mandible in a 45-year-old woman who was managed by hemimandibulectomy.