A unique case of late migration of an adjustable-loop femoral fixation button utilized during anterior cruciate ligament (ACL) reconstruction is presented. Imaging and physical examinations during the patient's postoperative course were unremarkable for graft or hardware failure. Two years postoperatively, symptomatic hardware migration occurred requiring arthroscopic removal. To our knowledge, this is the first reported case of late migration of an adjustable-loop femoral fixation button in ACL reconstruction. This case highlights that late loosening and migration of adjustable-loop femoral fixation devices in ACL reconstruction can occur despite demonstrated postoperative radiographic and clinical stability. Surgeons utilizing this fixation device should be aware of this potential complication to avoid delayed recognition and patient morbidity.