Giant pseudocyst is a very rare complication after incisional hernia repair with mesh. We present a case of 54-year-old male patient with a giant pseudocyst, which developed after incisional hernia repair with mesh. A patient was discussed during multidisciplinary team meeting and operative treatment was suggested to the patient. Extirpation of the cyst was accomplished. There was observed no defect in the abdominal wall. The patient was discharged on the 7th postoperative day. Ultrasonography two weeks after discharge again showed fluid collection. There were 6 aspirations every week starting from 400 ml serous fluid at the beginning and 60 ml at the end. There were no signs of fluid collection one month after the last aspiration. Surgical plastic treatment of giant pseudocyst after incisional hernia mesh repair is safe and feasible despite its low prevalence.