Class III malocclusions present a great challenge for many orthodontists, especially if malocclusions are found in adult patients and alongside other dental problems. This case report shows an adult patient with a skeletal class III anterior crossbite, a unilateral posterior crossbite on the right side, a congenital absence of both lateral incisors and retained deciduous teeth, and shift in the lower midline. The upper retained deciduous teeth and lower premolars were extracted. Leveling and alignment were initiated. Build-up composite resin placed on the first molars allowed for bite opening. The crossbites were corrected by using sequentially larger archwires combined with class III elastics until both the anterior and posterior crossbites were corrected. The impacted upper right canine was exposed using the closed eruption technique and leveled into the position of the upper lateral incisor. Miniscrews were utilized to close the residual spaces. Both canines were reshaped to simulate the upper lateral incisors. At the end of the treatment, good esthetic and functional results were obtained. In conclusion, orthodontic camouflage can be a viable option for treating patients with multiple skeletal and dental problems.