Chondromyxoid fibroma (CMF) is a benign tumor which usually occurs in skeletal long bones. Its presence in zygoma is extremely rare. The patient was a 47-year-old female, with chief complaint of painful swelling in the left side of zygoma since 1 month ago after a long-lasting painless swelling for about 15 years. Computed tomography scan showed an osteolytic lesion, in the body of left zygomatic bone with lobulated and well-demarcated margins. During surgery, the mass was completely excised and the histological feature of the tumor was in favor of CMF. CMF is benign tumor and complete resection is the treatment of choice.