This case series aims to elaborate and discuss the use of the quad helix, a type of slow maxillary expansion appliance in the mixed dentition period in three different clinical scenarios. Especially, in the field of pediatric dentistry, mixed dentition is the most critical stage in the development of occlusion and any malocclusion that can be corrected by the simple appliance in this stage is recommended. The appliance selection is one of the most important steps in the process of treatment planning to obtain the desired result. How to cite this article: Simon LS, Deepika UK, Philip S, et al. Quad Helix-A Versatile Appliance in Pedodontist's Arsenal: A Case Series. Int J Clin Pediatr Dent 2021;14(S-1):S114-S116.