Inhalant abuse is of growing concern in adolescent and young adult population in the underdeveloped regions of the world. In the absence of availability of definitive tests in routine clinical settings, diagnosis is often difficult. Equally difficult is management and ensuring adherence to therapy. We report two successive cases of inhalant abuse seen at the outpatient department of the Department of Psychiatry, Mental Health Institute, SCB Medical College, Cuttack, Orissa, India. We report here two cases of inhalant abuse: one with an unusual mode of abuse and another with atypical clinical presentation.