Pasteurella multocida is a small facultative anaerobic Gram-negative coccobacillus. Bites or scratches from cats or dogs are common transmission route causing zoonotic infections in humans. The pathogen rarely cause prosthetic joint infection. We report the first case, to our knowledge, of a prosthetic joint infection in a patient underwent liver transplantation caused by this pathogen. Pasteurella multocida is a high pace growing pathogen. Physician should raise awareness with related history especially in patients with immunosuppressive status. Management with the proper antibiotics administration in conjunction with timely surgical intervention could prevent devastating complications and preserve the artificial joint.