Purpose: To present a case of myopic choroidal neovascularization (CNV) leading to a full-thickness macular hole (MH) in a patient with macular schisis. Methods: A single case was evaluated. Results: A 65-year-old woman presented with myopic staphyloma and foveoschisis in both eyes. One month after the baseline presentation for myopic macular schisis, the patient presented with a paracentral scotoma in the left eye. Examination showed a submacular hemorrhage in the left eye. Optical coherence tomography of the left eye showed subretinal fluid and subretinal hyperreflective material in the fovea, suggestive of exudative myopia, and a small full-thickness MH (diameter 86 µm). After anti-vascular endothelial growth factor injections, the CNV showed interval improvement; however, a larger full-thickness MH (diameter 287 µm) developed in the left eye. Conclusions: A full-thickness MH developed secondary to CNV, leading to foveal dehiscence in an eye with baseline macular schisis.