We present the first case of peritoneal-cutaneous fistula (PCF) within ovarian carcinoma neoplastic infiltrates located inside a large abdominal hernia in a home hospice patient with massive ascites. It is an instructive case featuring a rapid diagnosis and efficient treatment of the PCF at home. As the patient refused hospitalization, she had successful paracentesis performed at home. Subsequent hydrocolloid dressing application, diuretics, and oral protein supplementation were recommended. Our intervention led to PCF closure, improved quality of life, and deepened the trust between the patient and the home hospice team. Our case demonstrates that in some instances, PCF may be efficiently treated at home, which may require paracentesis, appropriate dressings, and identification of all factors affecting healing. It also provides further support for the safety of paracentesis in home settings.