Ectodermal dysplasia (ED) is an inherited disorder that affects the ectoderm of a developing embryo and impacts structures that originate from it. It typically presents as a triad of missing teeth (anodontia/hypodontia), sparse hair (atrichosis/hypotrichosis), and lack of sweat glands (hypohidrosis), often accompanied by nail dystrophy and palmoplantar hyperkeratosis. There are two main types of this condition: X-linked anhidrotic or hypohidrotic and hidrotic (autosomal type). The oral manifestation of ED may include anodontia or hypodontia, with or without cleft lip and palate. Tooth loss leads to a decrease in the height of the alveolar ridges, resulting in a reduction of the vertical dimension of the lower face, disappearance of the vermilion border, and prominent lips. As a result, the affected person's face may resemble that of an elderly individual. The current case report aims to illustrate the prosthodontic rehabilitation of 16-year-old male patient with ectodermal dysplasia and complete anodontia, visiting Dentistry Teaching Hospital, Kabul, Afghanistan. Fortunately, this patient was acceptably managed with the collaboration of several disciplines.