Anemia is a worldwide health problem that manifests in different types. This illness has some causes, which affect body health generally. Studies have shown that some anemia types make humans more sensitive to infections.A 23-year-old woman was referred to our clinic with complaints about tooth mobility. Generalized severe alveolar bone loss was verified by a radiographic examination. After a comprehensive clinical examination and taking her medical history, we decided to schedule a medical consultation with a physician. Medical consultation revealed that the patient suffered from severe anemia. Her periodontal treatment was modified because of her systemic situation. After treatment, the patient was monitored for one year. Her periodontal and systemic statuses were stable during this period.In this case report, severe periodontal destruction was observed in a patient with severe iron and B(12) deficiency anemia.