Anterior sectional twin bracket appliance (ASTBA) is a sectional mechanism that involves two brackets on upper central incisors. This appliance is previously been used for correction of rotated incisors and midline spacing. But, detail biomechanics for single tooth crossbite correction is not previously explained. Here, in this article, we are presenting a detailed biomechanics of ASTBA for anterior single tooth crossbite correction along with case report. How to cite this article: Verma RK, Raghav P, Reddy MC, Kanwal R. Anterior Sectional Twin Bracket Appliance- Innovative Use for Correction of Single Tooth Crossbite: A Case Report with Biomechanics. Int J Clin Pediatr Dent 2015;8(1): 66-69.