Two female patients positive for human immunodeficiency virus and receiving antiretroviral treatment presented with esthetic concerns due to fixed dental prostheses in the anterior region. The patients had gingival recession and short clinical crowns in the esthetic zone. In both cases, the biologically oriented preparation technique was used to recreate ideal proportions between the teeth and gingivae. Since patients with human immunodeficiency virus experience a progressive deterioration of their immune systems and other significant comorbidities, a reduction in the number of traumatic clinical procedures is recommended. The use of this minimally invasive prosthetic protocol has not been previously reported in patients with human immunodeficiency virus. These cases demonstrate how short clinical crowns and gingival recession in the esthetic zone can be successfully treated with the biologically oriented preparation technique to avoid surgical procedures in patients with human immunodeficiency virus.