An 86-year-old man, who had undergone pleurodesis several times for intractable pneumothorax due to severe emphysema was referred to our department in order to treat for recurrent pneumothorax. Computed tomography after chest tube drainage revealed incomplete re-expansion right lung and giant cyst. Because the air leakage continued, we performed surgery. Thoracotomy revealed extensive intrathoracic adhesions due to chemical pleurodesis with OK-432. There was a fistula at the base of the giant cyst in the upper right lobe, which was firmly adhered to the superior vena cava and other mediastinal organs. It was not feasible to staple the lesion cyst, and covering the fistula was ineffective. Therefore, we tried to suture the fragile bulla manually to close the fistula. Adhesion was peeled off carefully to relieve tension of the bulla from mediastinum. The thin wall was folded and reinforced with polytetrafluoroethylene pledget, and then this thickened tissue was sutured to the lung with U-stitches to close the fistula. After the operation, pneumothorax improved. He was discharged without complications.