Human infections with Salmonella Blockley are uncommon, and cases described in the literature are usually gastrointestinal in origin. We report a case of an implantable cardioverter-defibrillator (ICD) infection in a 76-year-old Chinese man who presented with pain, redness, and warmth from the ICD pocket site, which later developed a sinus draining purulent material. S. Blockley was isolated from the wound and the patient underwent device removal and treatment with intravenous ceftriaxone. S. Blockley was cultured from the generator and the leads. The patient did not develop fever or bacteremia. This is, to the best of our knowledge, the first reported case of S. Blockley cardiac device infection.