Brain abscesses are relative rare in the developing world, with an incidence of 2% of all space occupying lesions. Deep-seated abscesses such as thalamic and basal ganglia abscesses are much rarer than abscesses in other locations of the brain, comprising 1.3-6% of all brain abscesses. These abscesses may present with hemiparesis, and subcortical aphasia has only been reported in a few cases throughout the literature. Here we present and discuss a case of thalamic brain abscess caused by S. anginosus that presented with subcortical aphasia.