We present a series of four patients who had been admitted to two hospitals in Addis Ababa after presenting with persistent and chronic diarrhoea. All patients were subsequently diagnosed to have Clostridioides difficile-associated pseudomembranous colitis, a disease that has long been regarded as a rare diagnosis in sub-Saharan Africa, and which has not yet been reported in Ethiopia. This case series is believed to create a much-needed awareness among physicians on the existence of this treatable but potentially fatal disease.