Membrane peeling is a common procedure for treating diseases of the vitreoretinal interface, such as macular holes and epiretinal membranes; however, potential complications include inner retinal dimples and inner retinal optic neuropathy. The current case series describes five patients who developed large, crescentic inner retinal defects after membrane peeling with diamond-dusted membrane scrapers. The changes visualized by en face optical coherence tomography were outside the fovea and followed the expected contours of membrane scrapers being used intraoperatively. The visual acuities at the last follow-up were 20/40 or better in all five patients.