Aniridia-associated glaucoma is often refractory to medical treatment. Glaucoma drainage device surgery is often considered after failed angle surgery. However, the potential complications of tube surgery in young children are not negligible. The failure rate of conventional trabeculectomy may be high and can require close and multiple postoperative follow-up visits. Here, we describe a child with aniridia who achieved good short-term results with deep sclerectomy. A 14-month-old girl was referred to our unit following bilateral trabeculotomies for aniridia-associated glaucoma and persistent uncontrolled intraocular pressure (IOP) in both eyes. She underwent sequential bilateral deep sclerectomies with microperforations. The patient achieved normalized IOP in both eyes after 6-month follow-up without any complications. Deep sclerectomy, with microperforations, may be a reasonable surgical procedure to perform in children with aniridia with failed angle surgery before contemplating tube shunt surgery.