Agenesis of multiple primary teeth is rare. A 6-year-old girl visited our department, in the absence of any other systemic abnormalities, on clinical and radiographic evaluation, it was revealed that she had only 6 primary teeth in her mouth. Maxillary and mandibular removable partial dentures were fabricated for prosthodontic rehabilitation. At the 6 months follow-up nutrition of the patient as well as self-confident appearance was improved. How to cite this article: Nirmala SVSG, Gokhale N, Sivakumar N, Quadar MA. Agenesis of Multiple Primary Teeth and Its Rehabilitation: A Case Report. Int J Clin Pediatr Dent 2013; 6(1):55-57.