A 1-month-old infant presented with a case of calcifying chronic epididymitis. Differential diagnosis was made from a testicular torsion and neoplasm. Serial ultrasound examination revealed a calcified lesion adjacent to the normal testis, thereby avoiding an unnecessary orchiectomy. Infantile epididymitis has been thought to be rare; however, it is occasionally encountered in the literature and calcification with chronic epididymitis in an infant has not been previously reported. On the other hand, an infant with scrotal calcification should be suspected of neoplasm. However, the tumor markers alpha-fetoprotein (AFP) and Human Chorionic Gonadotropin beta (HCG beta) were within the physiological range. Therefore, a diagnosis must be carefully made to avoid an unnecessary orchiectomy.