Infective endocarditis caused by Neisseria meningitidis (NM) is a very rare manifestation of invasive meningococcal disease with only a few cases described in the literature. We report a case of a native mitral valve endocarditis caused by NM in a 61-year-old female without meningitis. Our case highlights the importance of considering NM as one of the causative organisms of infective endocarditis, even in the absence of meningitis. Even though the cases of NM endocarditis have drastically decreased with the advent of antibacterials, NM should always be considered in the differential diagnosis in certain high-risk groups, like diabetics, polysubstance abusers, and elderly individuals. The prognosis is good with early appropriate antibiotic treatment with or without surgery.