Nontuberculous mycobacterial (NTM) infection is a common and important cause of chronic pulmonary disease, typically characterized by fibrocavitary and nodular-bronchiectatic forms on computed tomography (CT) of the chest. Structural lung disease and the host's immune status can affect NTM pulmonary infections. Herein, we report a rare case of an NTM pulmonary infection with multiple nodules and masses (with internal cavitation) in an immunocompetent patient exhibiting interstitial lung abnormality on a chest CT.