The description of corticosteroid injections as a treatment option for Ledderhose disease has received little attention in the literature and often only receives a passing comment in scientific papers. We present a short case series of two patients who underwent corticosteroid injection in combination with fenestration to treat painful Ledderhose disease nodules. Both patients had their lesions injected on two occasions. Significant reduction in pain and lesion volume was seen at 12 months post treatment. Our protocol combines fenestration with the use of triamcinolone acetonide (mixed with local anaesthetic) which we believe conveys further advantage over other steroid preparations or the corticosteroid infiltration alone.