Psoriasis is a common cutaneous disease, and often these patients require treatment with biologics. Screening for latent tuberculosis is an important step in the pre-biologic work-up. A 58-year-old woman with moderate-to-severe psoriasis was found to be positive for latent tuberculosis during pre-biologic screening. She received rifampicin for 6 months and had complete resolution of her psoriasis, with persistent remission at 1-year follow-up. Improvement could be attributed to the immunomodulatory effects of rifampicin. Another theory proposes the existence of a tuberculosis-related type of psoriasis that improves when tuberculosis is adequately treated.