We report a case of a 55-year-old woman with chronic renal failure and secondary tumoral calcinosis with rare intraosseous penetration of the humerus. Typical lobulated calcifications with associated layering "milk of calcium" were present about the right shoulder and elbow on conventional radiographs, computed tomography images and magnetic resonance images. Rare appearance of cortical destruction and intraosseous extension of tumoral calcinosis into the medullary space was observed in the proximal humerus on CT and MR images. Since there is concern for pathologic fracture, radiologists should be aware of this rare complication of chronic renal disease.