The novel Coronavirus, named SARS-COV-2, is responsible of the COVID-19. It is a viral pneumonia that appeared in December 2019 in Wuhan, China, and is causing a pandemic. Most of patients present mild symptoms, but in many other patients, acute respiratory distress (ARDS) is more likely to be developped. The actual problematic is the appearance of cases with virus reactivation. We report a case of virus reactivation in a COVID-19 patient with ARDS.