The use of biologic mesh, which is considered resistant to infection, has become common. It is preferred over synthetic mesh for use in contaminated fields. Fungal infection with infiltration of biologic mesh is rare and has not been reported. In this paper, we report a case of a patient who underwent multiple laparotomies and received multiple antibiotics and an azole antifungal. Biologic mesh was used, but it ultimately required removal because of chronic infection with Candida krusei. On biopsy, the yeast was found to have infiltrated the mesh.