Cytotoxic T lymphocyte associated antigen 4 (CTLA-4), also known as CD152, is a transmembrane protein encoded by the CTLA-4 gene that can down-regulate the activity of T cells when binding with its ligand, B7, a pathway also used by tumor cells to avoid T lymphocyte attack.
I-Cytotoxic T lymphocyte associated antigen 4 (CTLA-4), eyaziwa nangokuthi yi-CD152 iyiprotheni elidlulela ngale kolwelwesi elenziwe ikhodi yesakhi sofuzo i- CTLA-4 esikwazi ukulawula ukusebenza kwama-T cells lapho ebumbana ne-legand yayo, i-B7, indlela esetshenziswa nangama-tumor cells ukugwema ukuhlaselwa kwama-T lymphocyte