title: Cancer in Pregnancy and Lactation: The Motherisk Guide (Cambridge Medicine (Hardcover))
author: Gideon Koren
description: Based on research by members of the Consortium of Cancer in Pregnancy Evidence (CCoPE), Cancer in Pregnancy and Lactation provides evidence-based information needed to address the complex issues of the diagnosis, management and prognosis. This comprehensive volume is essential reading for all maternal-fetal medicine physicians, obstetricians, neonatologists, oncologists and pharmacologists.
zlib_text: GESTATIONAL TROPHOBLASTIC TUMORS
  497
  CHAPTER 23
  Gestational
  trophoblastic tumors
  Andrzej P. Kudelka, MD, Ralph S. Freedman, MD, PhD,
  and John J. Kavanagh, MD
  GTT
  Gestational trophoblastic tumors (GTTs) encompass a spectrum of neoplastic
  disorders that arise from placental trophoblastic tissue after abnormal fertiliza-
  tion. GTTs are classified histologically into four distinct groups: hydatidiform
  mole (complete and partial), chorioadenoma destruens (invasive mole), cho-
  riocarcinoma, and placental site tumor. Most commonly, GTT results in a
  hydatidiform “molar” pregnancy characterized by the lack of a fetus, tropho-
  blastic hyperplasia, edematous chorionic villi, and a loss of normal villous blood
  vessels.
  Most molar pregnancies spontaneously resolve after uterine evacuation with
  no further sequelae. However, at any time during or after gestation, malignant
  transformation may occur in approximately 10%-20% of molar pregnancies.
  Nearly two-thirds of these cases have an invasive mole co