title: Cancer Cytogenetics
author:  Sverre Heim 
description: Cancer Cytogenetics<br /> <br /> Second Edition<br /> <br /> Sverre Heim<br /> <br /> Felix Mitelman<br /> <br /> Over the past decade, cancer cytogenetics has become widely recognized both as a basic research tool for investigations of tumor biology and a clinical methodology providing vital insights into cancer development and progression. The first edition of this book presented a much-needed conceptual synthesis of this new and rapidly moving field. Now, Cancer Cytogenetics, Second Edition offers a comprehensive, expanded, and up-to-date summary of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations.<br /> <br /> Written by two leading experts, Cancer Cytogenetics, Second Edition provides an authoritative description of neoplastic processes at the chromosomal level of genomic organization. The book opens with a summary of cytogenetic methods and terminology, then reviews the key aspects of chromosomal abnormalities in cancer. The remainder of the book is devoted to the karyotypic and molecular genetic characteristics of specific neoplastic disorders and their clinical implications. Included in these sections are eleven entirely new chapters focusing on different types of non-hematologic neoplasms. This extensive expansion from the single-chapter coverage of the first edition was necessitated by a veritable explosion of knowledge in the field of solid tumor cytogenetics.<br /> <br /> Specific topics in the Second Edition include:<br /> * Acute and chronic myeloproliferative disorders<br /> * Myelodysplastic syndromes<br /> * Acute and chronic lymphoproliferative disorders<br /> * Malignant lymphomas<br /> * Solid tumors of the respiratory, digestive, and urinary tracts; breast, genital, endocrine, and nervous systems; eye, skin, and bone; and soft tissue<br /> <br /> This Second Edition of Cancer Cytogenetics is a valuable resource for researchers in a wide range of fields, including cytogenetics, medical and molecular genetics, cellular and molecular biology, oncology, and hematology. With its complete coverage of the cytogenetic mechanisms underlying neoplasia, this text will also be an indispensable reference for all clinicians involved in the diagnosis and treatment of cancer patients.
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  Cancers 2020, 12, 824; doi:10.3390/cancers12040824 
  www.mdpi.com/journal/cancers 
  Review 
  Chromosome Instability; Implications in Cancer 
  Development, Progression, and Clinical Outcomes 
  Raghvendra Vishwakarma 1 and Kirk J. McManus 1,2,* 
  1 Research Institute in Oncology & Hematology, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada; 
  raghvendra2375@gmail.com 
  2 Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada 
  * Correspondence: Kirk.McManus@umanitoba.ca; Tel.: +1-204-787-2833 
  Received: 10 March 2020; Accepted: 28 March 2020; Published: 29 March 2020 
  Abstract: Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a 
  driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately associated 
  with cancer development and progression. The presence, extent, and level of CIN has tremendous 
  implications for the clinical management and outcomes of those living with cancer. De