title: Structural Biology of Viruses
author: Wah Chiu
description: "An authoritative survey of our present understanding of many of the more functional aspects of viral structure. Besides explaining some of the basic principles of virus structure and outlining the methods used to determine structure, the contributions deal with specific viruses for which<br />structural approaches have proved particularly illuminating. Most emphasis is on animal, especially human, viruses but some consideration is given to assembly of bacterial viruses. . . .The editors are to be congratulated on having achieved a uniform/ polished presentation froma wide diversity of<br />authors. . . .A useful overview for researchers and students and the many so far unanswered questions raised point to an active area of research for some time to come." --Nature Structural Biology<br /><br />"An authoritative survey of our present understanding of many of the more functional aspects of viral structure. Besides explaining some of the basic principles of virus structure and outlining the methods used to determine structure, the contributions deal with specific viruses for which<br />structural approaches have proved particularly illuminating. Most emphasis is on animal, especially human, viruses but some consideration is given to assembly of bacterial viruses. . . .The editors are to be congratulated on having achieved a uniformly polished presentation from a wide diversity of<br />authors. . . .A useful overview for researchers and students and the many so far unanswered questions raised point to an active area of research for some time to come." --Nature Structural Biology<br /><br />"Structural biology is a relatively new field, dating back only to 1962, when Caspar and Klug first defined physical principles governing construction of symmetrical viruses. Impressively, these rules, in actual or modified form, are still relevant today and applicable not only to viruses but<br />also to the general issue of macromolecular recognition and interaction. This volume is a compilation of excellent review articles written, for the most part, by collaborating teams of molecular geneticists and crystallographers, leaders and innovators in this field. . . . From the perspectives of<br />both theoretical and experimental advances, this book illustrates (literally and figuratively!) how the field of structural biology has come of age as a powerful discipline. It is an outstanding review book for students new to the field as well as for entrenched scientists interested in comparative<br />structural biology."--The Quarterly Review of Biology
zlib_text: Original Article
  Composition of human-speciﬁc slow codons
  and slow di-codons in SARS-CoV and 2019-
  nCoV are lower than other coronaviruses
  suggesting a faster protein synthesis rate of
  SARS-CoV and 2019-nCoV
  Chu-Wen Yang a,*, Mei-Fang Chen b
  a Department of Microbiology, Soochow University, Shih-Lin, Taipei 111, Taiwan
  b Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan
  Received 7 March 2020; accepted 8 March 2020
  Available online - - -
  KEYWORDS
  2019-nCoV;
  Host-speciﬁc slow
  codons;
  Host tRNA genes
  Abstract
  Translation of a genetic codon without a cognate tRNA gene is affected by both the
  cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover,
  two consecutive slow codons (slow di-codons) lead to a much slower translation rate. Calcu-
  lating the composition of host speciﬁc slow codons and slow di-codons in the viral protein cod-
  ing sequences can predict the order of viral protein synthesis rates between different vir