title: Aging of the Genome: The Dual Role of DNA in Life and Death
author:  Jan Vijg 
description: <br />Jan Vijg is Professor at the Buck Institute for Age Research in Novato, California, USA.<br />
zlib_text: 2. Gene Expression and Differentiation
  2. Gene Expression and Differentiation
  I.  Differentiation 
  II.  Specification, Differentiation and Transdifferentiation
  III.  Programmed Death
  A.  The Processes of Apoptosis
  The nucleases
  The caspases
  Internal and external signals
  B.  Death Receptors
  C.  Role of Mitochondria
  D.  Anti- and Pro-Apoptotic Factors 
  E.  Developmental Role of Apoptosis
  F.  Alternative Programmed Cell Death
  IV.  Aging
  A.  Oxidative Damage
  B.  Genome Instability
  C.  Extrachromosomal Genome Instability
  D.  Genes Involved in Aging
  V.  Role of DNA Methylation
  A.  Parental Imprinting
  B.  Methylation and Gene Expression
  VI.  Histones and Chromatin Structure
  A.  The Histones and Other Nuclear Proteins
  B.  Posttranslational Modification of Histones
  C.  Role of DNA Methylation in Acetylation-Deacetylation of Histones
  D.  Chromatin Domains
  E.  The Chromodomain Proteins
  VII.  The Telomeres
  VIII.  Molecular Interactions in Differentation
  IX.  Stem Cells and Plasticity
  Appendix (Rev