title: Tumors of the Adrenal Glands and Extraadrenal Paraganglia - Volume 8 (Afip Atlas of Tumor Pathology Series 4)
author: Ernest E. Lack
description: This Fascicle follows in the wake of the third series Fascicle published in 1997 and two separate sets of second series Fascicles, Tumors of the Extra-adrenal Paraganglion System and Tumors of the Adrenal. In order to attain a better understanding of the varied morphology of neoplasms of the adrenal cortex, medulla and extraadrenal paraganglia, structural aspects of normal anatomy, including hyperplasia, are illustrated. Numerous new illustrations appear in this Fascicle, and a large number have been replaced or upgraded using high quality transparencies for digital imaging. The contributions of cytology and fine needle aspiration biopsy in diagnosis are emphasized, particularly with respect to adrenal tumors. Emphasis is also placed on the important role of molecular pathology and immunohistochemistry in tumor diagnosis, and in some cases may provide valuable information regarding prognosis.
zlib_text: RESERPINE
  CAS No. 50-55-5 
  First Listed in the Second Annual Report on Carcinogens 
  H3C
  O
  O
  O
  H3C
  C
  O
  C
  CH3
  O
  O
  CH3
  H3C
  O
  O
  H3C
  CARCINOGENICITY
  Reserpine is reasonably anticipated to be a human carcinogen based on limited evidence
  of carcinogenicity in experimental animals (NCI 1980). When administered in the diet, reserpine
  increased the incidence of adrenal medullary pheochromocytomas in male rats and mammary
  adenocarcinomas in female mice, and induced undifferentiated carcinomas of the seminal 
  vesicles in male mice. 
  When administered by subcutaneous injection, reserpine slightly
  increased adrenal pheochromocytomas in rats and mammary neoplasms in mice.
  An IARC
  Working Group considered the evidence for the carcinogenicity of reserpine in experimental
  animals to be limited (IARC 1980, 1982, 1987). 
  No adequate human studies of the relationship between exposure to reserpine and human 
  cancer have been reported (IARC 1976, 1980, 1982, 1987). The available evidence relating
  exposure to