title: Molecular Toxicology
author:  P. David Josephy 
description: <br /><strong>P. David Josephy</strong> is Professor of Molecular and Cellular Biology at the University of Guelph. <strong>Bengt Mannervik</strong> is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.<br />
zlib_text: 4,4'-OXYDIANILINE
  CAS No. 101-80-4 
  First Listed in the Fifth Annual Report on Carcinogens 
  O
  NH2
  H2N
  CARCINOGENICITY
  4,4'-Oxydianiline is reasonably anticipated to be a human carcinogen based on sufficient 
  evidence of carcinogenicity in experimental animals (IARC 1978, 1982, NCI 1980).
  When
  administered in the diet, 4,4'-oxydianiline increased the incidence of adenomas of the harderian
  gland and hepatocellular adenomas or carcinomas in mice of both sexes, follicular cell adenomas
  in female mice, and hepatocellular carcinomas or neoplastic nodules and follicular cell adenomas 
  or carcinomas of the thyroid in rats of both sexes.
  When administered by subcutaneous
  injection, the compound induced malignant liver cell tumors in rats. 
  No data were available to evaluate the carcinogenicity of 4,4'-oxydianiline in humans 
  (IARC 1982, 1987). 
  PROPERTIES
  4,4'-Oxydianiline is a nonflammable, colorless, odorless, crystalline aromatic diamine
  that is insoluble in water, benzene, carbon tetrachlor