title: Chromatographic Methods in Clinical Chemistry and Toxicology
author: Roger Bertholf
description: Among the vast array of methods available for biochemical analysis,chromatography occupies a venerable station. Few analytical methodshave had such vital impact on the development of clinical chemistryand toxicology. In this book, the editors have assembled across-section of contemporary applications of chromatographicmethods used in clinical chemistry and toxicology.
zlib_text: C.I. BASIC RED 9 MONOHYDROCHLORIDE 
  CAS No. 569-61-9 
  First Listed in the Fifth Annual Report on Carcinogens 
  NH2
  +
  Cl-
  H2N
  NH2
  CARCINOGENICITY
  C.I. Basic Red 9 monohydrochloride is reasonably anticipated to be a human carcinogen
  based on sufficient evidence of carcinogenicity in experimental animals (NTP 1986). When
  administered in the diet, the compound induced subcutaneous fibromas, thyroid gland follicular 
  cell adenomas and carcinomas, and Zymbal gland carcinomas in rats of both sexes, and 
  squamous
  cell carcinomas, trichoepitheliomas, sebaceous adenomas of the skin, and 
  hepatocellular carcinomas in male rats.
  Increased incidences of mammary gland tumors in
  female rats also may have been related to exposure to the compound. 
  C.I. Basic Red 9 
  monohydrochloride induced hepatocellular carcinomas in mice of both sexes and adrenal gland
  pheochromocytomas in female mice. Increased incidences of hematopoietic system tumors in 
  female mice also may have been related to exposure to the c