title: Molecular Toxicology
author:  P. David Josephy 
description: <br /><strong>P. David Josephy</strong> is Professor of Molecular and Cellular Biology at the University of Guelph. <strong>Bengt Mannervik</strong> is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.<br />
zlib_text: CAS No. 76180-96-6
  First listed in the Tenth Report on Carcinogens
  CARCINOGENICITY
  2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is reasonably anticipated to be a human
  carcinogen based on sufficient evidence of benign and malignant tumor formation at multiple
  tissue sites in multiple species of experimental animals (IARC 1993).  Oral exposure of rats to
  IQ induces neoplasms of the mammary gland, liver, small intestine, clitoral gland, oral cavity,
  and Zymbal gland in females and neoplasms of the liver, skin, colon, small intestine, oral cavity,
  and Zymbal gland in males.  Oral exposure of mice to IQ induces neoplasms of the lung, liver,
  and forestomach in males and females.  Intraperitoneal injection of IQ in mice and oral exposure
  in cynomologus monkeys causes liver tumors.
  No adequate epidemiology studies have been reported that would indicate a human
  cancer risk specifically associated with exposure to IQ or other heterocyclic amines (HCAs).
  However, published epidemiology studies p