title: Microbial Biotechnology: Fundamentals of Applied Microbiology
author:  Alexander N. Glazer 
description: "A wonderful text for modern day study of microbes and their fantastic activities. It brings together so many aspects of microbes including their diversity, metabolism, genetics, etc., etc., etc. I wish I had such a book at my side when I was a student. The text will bring the wonders of microbiology to the student in a way that he/she will never forget." <br />PROFESSOR ARNOLD L. DEMAIN <br />Founder of Fermentation Microbiology Dept.,Merck &amp; Co., Inc.; <br />Formerly Professor of Industrial Microbiology, MIT; <br />Past President,Society for Industrial Microbiology<br /><br />"The second edition of Glazer and Nikaido's Microbial Biotechnology provides an essential intellectual link between the breakthroughs of the last ten years in our understanding of the fundamental processes that drive microbial function and the application of this knowledge to the technological challenges faced by society. The book is unique in the clarity with which specific industrial problems are delineated and in the cogent description of how current technology provides solutions. The range of subjects covered in this volume is astounding. They extend from microbial metabolites, antibiotics and polymers to recombinant vaccine production and enzyme and metabolic engineering. The basic scientific principles involved in associated areas, from microbial genetics to transgenic plant production and the world of 'Omics are presented in a straight forward manner so that a reader with some general biology background can grasp the the concepts and their application. In addition enough details and useful references are provided to engage the most sophisticated reader. Microbial Biotechnology fills the void generated by the absence of a suitable scientifically sophisticated text for an advanced undergraduate or graduate course in Biotechnology. It will also be a required addition to the library of all of those associated with industrial microbiology and the biotechnology and pharmaceutical industries including the research workers, patent lawyers, regulatory agents and even an occasional venture capitalist." <br />MELVIN I. SIMON <br />Biaggini Professor of Biology, California Institute of Technology; <br />Founder of the microbial biotechnology company Diversa<br /><br />"Microbial Biotechnology comprehensively covers both the basics and complexities of the microbial world as it applies to biotechnology. Having the biochemical structures in place along with descriptive paragraphs of microbial facts is an added value in teaching students the amazing and wonderful capabilities of these invisible strangers and friends. From microbial diversity to recombinant and synthetic vaccines to primary and secondary metabolites to environmental applications, Microbial Biotechnology embraces the reader with both the primary foundations of microbiology to the latest advanced microbial methods being practiced in laboratories around the world. Reading the book reminded me as to why I became a applied microbiologist in the first place." <br />JENNIE HUNTER-CEVERA <br />President University of Maryland Biotechnology Institute; <br />Past President, Society for Industrial Microbiology<br /><br />"The application of science to practical problems of humanity has at times been approached with an air of apology. No longer. Biotechnology, especially of the microbiological variety is so closely linked to its scientific roots as to make for a seamless continuum. Nowhere is this more vividly demonstrated than in the second edition of Microbial Biotechnology, written by two leading scientists who have made stellar contributions to microbiology and biochemistry. This book, based on their authoritative insights and experience, unites the "bio" and "technology" in a masterful way. This is what we expected from the update of a classic in its field." <br />MOSELIO SCHAECHTER <br />Distinguished Professor, Emeritus, <br />Tufts University School of Medicine; <br />Past President, American Society for Microbiology<br /><br />"Microbial Biotechnology is engrossing to read, and will be appreciated by anyone wishing to better understand the diverse means by which microbes are being exploited to solve biomedical, food, energy, and environmental problems." <br />K.A. Newman, Choice Magazine
zlib_text: ORIGINAL PAPER
  Viability and cellulose synthesizing ability of Gluconacetobacter
  xylinus cells under high-hydrostatic pressure
  Naoto Kato Æ Takako Sato Æ Chiaki Kato Æ Masao Yajima Æ Junji Sugiyama Æ
  Takahisa Kanda Æ Masahiro Mizuno Æ Kouichi Nozaki Æ Shigeru Yamanaka Æ
  Yoshihiko Amano
  Received: 3 March 2007 / Accepted: 15 April 2007 / Published online: 21 July 2007
  � Springer 2007
  Abstract
  The effect of pressure on viability and the
  synthesis of bacterial cellulose (BC) by Gluconacetobacter
  xylinus ATCC53582 were investigated. G. xylinus was
  statically cultivated in a pressurized vessel under 0.1, 30,
  60, and 100 MPa at 25�C for 6 days. G. xylinus cells re-
  mained viable and retained cellulose producing ability
  under all the conditions tested, though the production of
  cellulose decreased with increasing the pressure. The BCs
  produced at each pressure condition were analyzed by ﬁeld
  emission scanning electron microscopy (FE-SEM) and
  Fourier Transform Infrared (FT-IR). FE-SEM revealed t