title: Childhood Leukemias (Cambridge Medicine (Hardcover))
author: Ching-Hon Pui
description: Review of the previous editions: '... comprehensively referenced and the indexing is simple to use ... informative and relevant ... I would commend the book to anyone looking for an up-to-date and comprehensive reference monograph on childhood leukaemia.' The Bulletin of The Royal College of Pathologists<br /><br />'This is an exceptional book that's highly extensive in coverage of the very complex field of leukemias among children and to some extent, adolescents. The information in it is presented well, and written very clearly. The fact that it is in its third edition speaks for itself. The first and second editions had to have been successful by providing great value in terms of not just the knowledge but also its ease of use.' Nano Khilnani, Biz India Online News (www.bizindia.net)
zlib_text: REASONABLY ANTICIPATED TO BE A HUMAN CARCINOGEN
  TENTH REPORT ON CARCINOGENS
  CHLORAMPHENICOL
  CAS No. 56-75-7
  Carcinogens because human data considered inadequate to list at that time, 
  relisted in Tenth Report on Carcinogens
  CARCINOGENICITY
  Chloramphenicol is reasonably anticipated to be a human carcinogen, based on limited
  evidence of carcinogenicity from studies in humans.  Numerous case reports have shown
  leukemia to occur after medical treatment for chloramphenicol-induced aplastic anemia (IARC
  1990).  Three case reports have documented the occurrence of leukemia after chloramphenicol
  therapy in the absence of intervening aplastic anemia (IARC 1990).  In a case-control study in
  China, Shu et al. (1987, 1988) found elevated risks of childhood leukemia, which increased
  significantly with the number of days chloramphenicol was taken.  Two case-control studies
  (Issaragrisil et al. 1997, Laporte et al. 1998) found high, but nonsignificant, increases in the risk
  of aplastic anemia associa