title: Enzymes in Biomass Conversion (ACS Symposium Series)
author: Gary F. Leatham
description: Gary F. Leatham is at University of Wisconsin at Madison. Michael E. Himmel is at Solar Energy Research Institute.
zlib_text: Advances in Biochemical Engineering/
  Biotechnology,Vol. 66
  Managing Editor: Th. Scheper
  © Springer-Verlag Berlin Heidelberg 1999
  On-line and Off-line Monitoring of the Production 
  of Cephalosporin C by Acremonium chrysogenum
  G. Seidel, C. Tollnick, M. Beyer and K. Schügerl*
  Institut für Technische Chemie der Universität Hannover, Callinstr. 3, D-30167 Hannover,
  Germany
  * E-mail: Schuegerl@mbox.iftc.uni-hannover.de
  Process monitoring of cephalosporin C formation by Acremonium chrysogenum in laboratory
  investigations is considered. The goal of these investigations is the identification of
  bottlenecks in the biosynthesis and the improvement of the process performance. Based on
  reports of other research groups and own experience the key parameters were selected,which
  influence the process performance.They are: dissolved oxygen and pH values.In addition the
  concentrations of biomass, DNA, glucose and reducing sugars (glucose, maltose, maltotriose
  and oligosaccharides), methionine, other nit