title: The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy
author: Eric Murillo-Rodriguez
description: Dr. Murillo-Rodrguez is a psychologist and PhD in Biomedical Sciences, both degrees obtained at the National Autonomous University of Mexico (UNAM). He completed his post-doctoral training at Harvard Medical School. He serves as editor in scientific journals such as The International Journal of Neuropsychopharmacology, PLoS ONE, among others. He has published over 50 articles published in peer-review journals, 10 chapters in books and numerous presentations in domestic and international scientific meetings. He is a member of several scientific societies, including the Society for Neuroscience (USA). He has received academic awards such as the Young Investigator Award from the World Federation of Sleep Research and Sleep Research Societies Society, and am member of the National System of Researchers (Level 1) of National Council of Science and Technology (Mxico). His scientific interest lies in the study of the neurobiological mechanisms of the endocannabinoid system on modulating the sleep-wake cycle.
zlib_text:  
   
  Int. J. Mol. Sci. 2020, 21, 2850; doi:10.3390/ijms21082850 
  www.mdpi.com/journal/ijms 
  Review 
  Endocannabinoid-Mediated Neuromodulation  
  in the Olfactory Bulb: Functional and  
  Therapeutic Significance 
  Naina Bhatia-Dey and Thomas Heinbockel * 
  Department of Anatomy, Howard University College of Medicine, Washington, DC 20059, USA; 
  naina.bhatiadey@howard.edu 
  * Correspondence: theinbockel@howard.edu; Tel.: +(202)-806-0058 
  Received: 11 March 2020; Accepted: 17 April 2020; Published: 19 April 2020 
  Abstract: Endocannabinoid synthesis in the human body is naturally occurring and on-demand. It 
  occurs in response to physiological and environmental stimuli, such as stress, anxiety, hunger, other 
  factors negatively disrupting homeostasis, as well as the therapeutic use of the phytocannabinoid 
  cannabidiol and recreational use of exogenous cannabis, which can lead to cannabis use disorder. 
  Together with their specific receptors CB1R and CB2R, endocannabinoids are major components of 