title: Essentials of Chemical Biology: Structure and Dynamics of Biological Macromolecules
author: Andrew D. Miller
description: ?<i>Essentials in Chemical Biology</i> is a valuable resource notonly for chemistry students who are venturing into and interestedin biological systems, but also biochemistry and biology studentswho want a fundamental understanding of the physical and chemicalbasis of biology and the techniques used in its study.?(<i>Chemistry World</i>, August 2009)
zlib_text: Evolutionary perspectives on protein structure,
  stability, and functionality
  Richard A. Goldstein
  Biophysics Research Division and Department of Chemistry, University of Michigan,
  Ann Arbor, MI 48109-1055
  Abstract. Proteins are the result of a long process of evolution. It is due to this process
  that they have developed properties rather diﬀerent from those of random strings of
  amino acids. If we wish to understand the properties of proteins, we need to understand
  the underlying process of Darwinian evolution, and how its stochastic nature interacts
  with the underlying ﬁtness landscape. In this review, I describe some of the underlying
  theory of evolution. I then discuss how these theories can help us understand the
  structure, thermodynamics, and functioning of naturally-occurring proteins.
  Introduction
  A number of diﬀerent perspectives have recently changed the way that we under-
  stand evolution and its eﬀect on biological macromolecules. The ﬁrst perspective
  is an increased appreciat