title: Introduction to Pandemic Influenza (Animal & Veterinary Science)
author: Jonathan Van-Tam
description: Jonathan Van-Tam is Professor of Health Protection at City Hospital, Nottingham.
zlib_text: 1 
   
  Computational Design of Peptides to Block Binding 
  of the SARS-CoV-2 Spike Protein to Human ACE2 
  Xiaoqiang Huang1, Robin Pearce1 and Yang Zhang1,2* 
  1Department of Computational Medicine and Bioinformatics, 2Department of Biological 
  Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA 
   
  * To whom correspondence should be addressed.  
  Tel: +1 734 647 1549; Fax: +1 734 615 6443; Email: zhng@umich.edu 
   
   
  .
  CC-BY-NC-ND 4.0 International license
  author/funder. It is made available under a
  The copyright holder for this preprint (which was not peer-reviewed) is the
  . 
  https://doi.org/10.1101/2020.03.28.013607
  doi: 
  bioRxiv preprint 
  
  2 
   
  ABSTRACT 
  The outbreak of COVID-19 has now become a global pandemic and it continues to spread rapidly 
  worldwide, severely threatening lives and economic stability. Making the problem worse, there is 
  no specific antiviral drug that can be used to treat COVID-19 to date. SARS-CoV-2 initiates its 
  entry into human cells