title: Biomarkers in Neoplastic Neuropathology
author: Fausto Rodriguez
description: This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on biobanking covers the equally important topic of optimal preservation of tissue and includes consideration of ethical considerations raised by the use of tissue obtained in clinical settings. The closing section discusses the major categories of neoplastic disorders involving the nervous system, with emphasis on diagnostic, prognostic, and predictive biomarkers used in the pathologic evaluation of different types of brain tumor.
zlib_text:  
  Int. J. Mol. Sci. 2020, 21, 2125; doi:10.3390/ijms21062125 
  www.mdpi.com/journal/ijms 
  Article 
  Absence of Nuclear p16 Is a Diagnostic and 
  Independent Prognostic Biomarker in Squamous Cell 
  Carcinoma of the Cervix 
  Saioa Mendaza 1, Joaquín Fernández-Irigoyen 2, Enrique Santamaría 2, Tamara Zudaire 3,  
  Rosa Guarch 3, David Guerrero-Setas 1,3, August Vidal 4, José Santos-Salas 5,  
  Xavier Matias-Guiu 4,6, Karina Ausín 2,  
  María José Díaz de Cerio 3 and Esperanza Martín-Sánchez 1,* 
  1 Molecular Pathology of Cancer Group, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), 
  Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), 
  Irunlarrea 3, 31008 Pamplona, Spain 
  2 Proteored-ISCIII, Proteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), 
  Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), 
  Irunlarrea 3, 31008 Pamplona, Spain 
  3 Department of Pathology, Complejo Hospitalario de 