title: Means to an End: Apoptosis and Other Cell Death Mechanisms
author:  Douglas R Green 
description: Green (St Jude Children s Research Hospital) provides a comprehensive look at the current understanding of the multilayered processes by which cells in the body died. Means to an End is a complex but improbably thrilling read that manages to convey not only the hard work associated with cell biology but also the joy of its eureka moments. --Choice<br /><br />This book gracefully covers a wide variety of subjects and, in my opinion, distills our knowledge of cell death into an accessible text that is both enjoyable to read and appropriate for a broad audience. Green covers more territory than many specialized books and does this by elimination of detail. Because of this approach, the book is a must read for students, clinicians, and experts in other fields wanting to learn more about cell death. Although the content may be very familiar to experts in the field, my suspicion is that they too will enjoy and benefit from reading this entertaining book. --Cell<br /><br />...(the book) is composed in a simple and accessible way, with an evenness and homogeneity in style and presentation, and the field is captured in 200 concise pages with informative illustrations....As a leader in the field of cell death since the late 1980s, Dr. Green's contribution has been pivotal, particularly in defining the process of activation-induced apoptosis in T cells....We cannot do better than echo the words of Martin Raff, one of the founders of the cell death field, in his Foreword: [This] complexity has created a pressing need for a comprehensive stock taking a cool, clear, overview of cell death that cuts through the detail in a logical and engaging way. Doug Green has achieved all of this admirably. ...any student, medic, mature biologist, or even an interested layman would be attracted and inspired by this book, as it provides both a solid basis to those entering the field as well as a fresh and provocative viewpoint for the cognoscenti. --Cell Death and Differentiation<br /><br />This is an important publication for researchers on the fringes of the cell death field, or anyone who wants a more global perspective on apoptosis. The book covers research from chemistry, biochemistry, cell biology, developmental biology, neurobiology, immunology, and cancer biology, and is able to explain complex experiments in an accessible way. After reading, anyone will develop a more comprehensive understanding of the numerous scientific fields involved in studying the mechanisms and importance of apoptosis. --The Quarterly Review of Biology
zlib_text: © 1999 by CRC Press LLC
  3
  Apoptosis in Neurodegenerative Disorders
  Donald E. Schmechel
  CONTENTS
  3.1 Introduction
  3.2 Cell Death in Normal Development and Aging
  3.2.1 Spinal Cord
  3.2.2 Midbrain, Forebrain, Retina
  3.2.3 Cerebral Cortex: Example of Cortical Subplate
  3.2.4 Hippocampus
  3.2.5 Deafferentation
  3.3 Apoptotic Cell Death in Early Onset 
  Neurodegenerative Disorders
  3.3.1 Necrosis–Apoptosis Continuum
  3.3.2 Batten Disease
  3.3.3 Spinal Muscular Atrophy
  3.3.4 Retinal Degeneration
  3.3.5 Triplet Repeat Diseases
  3.3.6 Mitochondrial Disorders
  3.4 Apoptosis in Alzheimer’s, Parkinson’s, and Motor 
  Neuron Disease
  3.4.1 Modeling Chronic Neurodegenerative Diseases
  3.4.2 Evidence for Apoptosis in AD
  3.4.3 Role of AD Genes: Presenilins, Amyloid Precursor 
  Polypeptide, Apolipoprotein E
  3.4.4 Evidence for Apoptosis in Parkinson’s Disease
  3.4.5 Evidence for Apoptosis in Motor Neuron Disease (ALS) 
  and Related Disorders
  3.4.6 Role of ALS Genes: Copper, Zinc Superoxide 
  Dismutase Mutations 
  3.4.7 Evi