title: Molecular Toxicology
author:  P. David Josephy 
description: <br /><strong>P. David Josephy</strong> is Professor of Molecular and Cellular Biology at the University of Guelph. <strong>Bengt Mannervik</strong> is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.<br />
zlib_text: THIOACETAMIDE
  CAS No. 62-55-5 
  First Listed in the Third Annual Report on Carcinogens
  S
  H3C
  C
  NH2
  CARCINOGENICITY
  Thioacetamide is reasonably anticipated to be a human carcinogen based on sufficient
  evidence of carcinogenicity in experimental animals (IARC 1974, 1982). When administered in 
  the diet, thioacetamide induced hepatocellular carcinomas in mice of both sexes, hepatocellular
  neoplasms in male rats, and bile duct or cholangiocellular neoplasms in rats of both sexes.
  No adequate human studies of the relationship between exposure to thioacetamide and
  human cancer have been reported (IARC 1974). 
  PROPERTIES
  Thioacetamide occurs as colorless or white leaflets that have a slight odor of mercaptans.
  It is soluble in water and ethanol, and sparingly soluble in ether. When heated to decomposition,
  it emits toxic fumes of nitrogen oxides and sulfur oxides.
  Thioacetamide is available as a
  laboratory grade containing 99% active ingredient. It forms compounds and sulfides with salts
  of he