title: Molecular Toxicology
author:  P. David Josephy 
description: <br /><strong>P. David Josephy</strong> is Professor of Molecular and Cellular Biology at the University of Guelph. <strong>Bengt Mannervik</strong> is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.<br />
zlib_text: 2-NAPHTHYLAMINE 
  CAS No. 91-59-8 
  First Listed in the First Annual Report on Carcinogens 
  NH2
  CARCINOGENICITY
  2-Naphthylamine is known to be a human carcinogen based on sufficient evidence of 
  carcinogenicity in humans (IARC 1979, 1982, 1987). Epidemiological studies have shown that
  occupational exposure to 2-naphthylamine, either alone or when present as an impurity in other
  compounds, is associated causally with bladder cancer in workers. 
  An IARC Working Group reported that there is sufficient evidence of carcinogenicity of 
  2-naphthylamine in experimental animals (IARC 1979, 1982, 1987). When administered orally,
  by gavage or in the diet, 2-naphthylamine induced urinary bladder carcinomas in hamsters, dogs,
  nonhuman primates, and mice (IARC 1979, 1974). 
  PROPERTIES
  2-Naphthylamine occurs as colorless or white to reddish crystals with a faint aromatic
  odor that darken in air to a purple-red color. It is soluble in hot water, alcohol, ether, and many
  organic solvents. 2-Naphthylamine