title: Protein Folding
author: Thomas E. Creighton
description: The phenomenon of protein folding has become the focus of intense scientific inquiry. Researchers have realised the importance of understanding how proteins adopt their folding conformations, and are developing experimental techniques to attack this problem. , Protein Folding is a report on the current state of this crucial area of research-the 4y experiments, techniques, and implications of recent findings on modem biotechnology and biomedicine. Its authors are the world's leading investigators in this field, including: R M. Richards, Department of Molecular Biophysics and Biochemistry, Yale University - Janet M Thornton, Biomolecular Structure and Modelling Unit, University College,. . London, UK - Peter L Privokv, Institute of Protein Research, Academy of Sciences, Moscow - Martin Karplus and E. S h, Department of Chemistry, Harvard University - Franz X Schmid, Department of Biochemistry, Universitat Bayreuth, Germany . Oleg B. Ptilsyn, Institute of Protein Research, Academy of Sciences, Moscow Thomas E. Creighton, European Molecular Biology Laboratory, Heidelberg, Germany David P. Goldenberg, Department of Biology, University of Utah - Jean-Renaud Garel, Laboratoire d'Enzymologie du CNRS, Gifsur-Yvette, France - Robert B. Freedman, Biological Laboratory, University of Kent, Canterbury, UK.
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  Christopher Wood
  Molecular Conformations
  
  Download free ebooks at bookboon.com
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  Molecular Conformations
  © 2010 Christopher Wood & Ventus Publishing ApS
  ISBN 978-87-7681-545-5
  
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  Molecular Conformations
  4 
  Contents
  Contents
  1.  
  Genetic origins of amino acids 
  6
  1.1  
  Constituents and organisation of DNA 
  6
  1.2  
  Folding of DNA 
  7
  1.3  
  The codon structure of DNA 
  9
  1.4  
  Gene structure 
  10
  2.  
  Transcription and translation 
  11
  2.1  
  Transcription 
  11
  2.2  
  Translation 
  12
  2.2.1  
  Transfer RNA 
  12
  2.2.2  
  Protein formation by ribosomes 
  13
  2.2.3  
  Open reading frames of mRNA 
  15
  3.  
  Amino acid geometries and protein folding 
  16
  3.1  
  Amino acid structure and bond flexibility 
  16
  3.2  
  Principles of protein folding 
  19
  3.2.1  
  Formation of secondary-structure elements 
  19
  3.2.2  
  Causes and consequences of misfolding 
  21
  3.2.3  
  Mechanisms of protein folding 
  22
  Stand out from the crowd