title: Diseases of Poultry
author: Y. M. Saif
description: <i>"This book is hugely impressive. Anybody at all who is involved in poultry health, in the widest sense, should have this book at hand." </i><b>Avian Pathology</b>
zlib_text: Recombinant infectious bronchitis coronavirus H120 with the spike
  protein S1 gene of the nephropathogenic IBYZ strain remains attenuated
  but induces protective immunity
  Yi Jiang, Xu Cheng, Xiumei Zhao, Yan Yu, Mingyan Gao, Sheng Zhou ⇑
  Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou 225125, Jiangsu, China
  a r t i c l e
  i n f o
  Article history:
  Received 17 May 2019
  Received in revised form 28 December 2019
  Accepted 2 January 2020
  Available online 11 February 2020
  Keywords:
  Infectious bronchitis virus
  Attenuation
  Spike
  Vaccine
  QX-like
  a b s t r a c t
  Infectious bronchitis (IB) is a highly infectious viral disease responsible for major economic losses in the
  poultry industry. A reverse genetic vaccine is a safe, rapid, and effective method of achieving IB preven-
  tion and control. In this study, we constructed the recombinant strain, rH120-S1/YZ, using a reverse
  genetic system, based on the backbone of the H120 vaccine strain, with the S1 gene replaced with that
  of t