original_query: What is the function of isocitrate dehydrogenase?
query: What is the function of isocitrate dehydrogenase?
answer: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2.  This is a two-step process involving oxidation of isocitrate to oxalosuccinate, followed by decarboxylation to form alpha-ketoglutarate.  Different isoforms exist, with IDH3 functioning in the citric acid cycle and IDH1/IDH2 working outside of it.