original_query: What are the effects of the cited metabolites on arterial vascular sites?
query: What are the effects of 12(S)-HETE, 12(S)-HpETE, and 12(R)-HETE on arterial vascular sites?
answer: The effects of these metabolites on arterial vascular sites vary depending on the specific metabolite, the arterial site, and the animal species.  12(S)-HETE and 12(S)-HpETE generally stimulate dilation in rat mesenteric arteries, pig coronary microvessels, and mouse mesenteric arteries.  However, 12(R)-HETE constricts dog renal arteries.  The effects on rat basilar artery and human placental arteries are also implicated but less clearly defined.