original_query: What is the relationship between NF-κB and interleukin 1 alpha in senescent cells?
query: What is the relationship between NF-κB and interleukin 1 alpha in senescent cells?
answer: In senescent cells, NF-κB and interleukin 1 alpha mutually induce each other in a positive feedback loop, leading to the production of senescence-associated secretory phenotype (SASP) factors.