original_query: What is the estimated percentage of the genetic component of insulin resistance that e loci account for?
query: What is the estimated percentage of the genetic component of insulin resistance that loci near the NAT2, GCKR, and IGFI genes account for?
answer: Loci near the NAT2, GCKR, and IGFI genes are estimated to account for only 25-44% of the genetic component of insulin resistance.