original_query: What are the transmembrane molecules that can interact directly with microbes?
query: What are the transmembrane molecules that can interact directly with microbes?
answer: SLAMF receptors are cell surface transmembrane molecules that can interact directly with microbes, causing phagocytic cells to migrate to the area.  SLAMF1 and SLAMF6 are known to directly interact with outer membrane porins on gram-negative bacteria. SLAMF2 is known to bind gram-negative bacteria.