original_query: What is nonsynaptic plasticity?
query: What is nonsynaptic plasticity?
answer: Nonsynaptic plasticity is a form of neuroplasticity involving modifications to ion channel function in a neuron's axon, dendrites, and cell body.  This alters the neuron's intrinsic excitability and influences synaptic integration, spike generation, and other cellular mechanisms, impacting higher brain functions like learning and memory.  It's distinct from synaptic plasticity, which focuses on changes in connections between neurons.