Abstract: Firearms injuries have an legal and medico-legal importance, and are especially lethal when they reach the craniofacial regions of the victim. The medical-legal properties of this type of lesion are points that need to be studied because they are useful for investigations related to each case. Thus, the present study aims to identify the characteristics of craniofacial lesions resulting from firearm projectiles, observed in corpses necropsied at five Institutes of Legal Medicine in Brazil, to register the most affected craniofacial regions by this type of injury and to verify the demographic profile of the victims. For that, a retrospective study was carried out on the autopsy records produced in the first semester of 2015, at the Institutes of Legal Medicine in Porto Velho - RO, João Pessoa - PB, Vitória - ES, Porto Alegre - RS and Brasília ¿ DF, randomly selected in each region of Brasil. Reports were selected of corpses of any sex and skin color, aged between 12 and 80 years and presenting at least one craniofacial bone lesion by firearm. Data extracted included sex, skin color and age of the victim, craniofacial region reached, shooting distance, shape and size of the injuries and manner of death. Based on the 868 reports analyzed, it was possible to observe 1700 entrance lesions of firearm projectiles in craniofacial regions. Among cases of known manner of death, homicides were the most frequent with 447 (97.0%) cases, compared with 13 (2.8%) suicides and 1 case (0.2%) of accident with gunshot. It was observed a higher frequency of male victims (93.3%), mixed race (62.0%), between the ages of 12 and 29 years (59.4%). In all cases considered as suicide or accident there was only one entrance wound, but in 82.8% of the homicides there were multiple gunshot wounds. The craniofacial most affected regions were temporal (25.2%) and occipital (19.8%). The most common sites of projectiles exit were the temporal (25.3%) and parietal (16.1%). All cases of suicide were related to contact shot (69.2%) or close range shot (30.8%), and among the homicides the distant range shots were more frequent (54.0%). The shape of entrance wounds was mostly circular (56.8%) and oval (31.3%), and among the exit injuries, the lesions were irregular (43.3%) and starry (24.1%). The entrance wounds showed smaller sizes than the exit lesions, with averages of 9.85 mm and 13.37 mm respectively (p <0.0001, Mann-Whitney Test). The present study concluded that homicides are responsible for most of the deaths caused by projectiles, with victims mostly male, brown and young. Entrance injuries are more frequent in the temporal, occipital and parietal regions, caused by distance shots, with circular or oval outline, and smaller size than the exit injuries. Such data can base investigations and future researches based on the analyzes discussed in the present work