diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..884813dd16650df34831385d765007d0befa28c2 --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Serine/threonine-protein kinase, active site [IPR008271]"} \ No newline at end of file diff --git a/interpro_active_site/basic/plot_0.png b/interpro_active_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..763cacfb5924a091154c04579b392be79a9663e3 --- /dev/null +++ b/interpro_active_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f6328e053adb764667216c08fa1f432a95d476f9026fff65179bc442a76a1f29 +size 157608 diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0793faafe12ef92648ce345c6a4c9567622c4fc8 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0971ddb3f197b61356cc6c1b1b47da6cec11814adc213948d50720d95853bce2 +size 74716 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..75a85c70cb26a98f054016fdd5b0b1f257dcd9a6 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 53, + "title": "Average number of proteins per term", + "value": 2.509433962264151 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..348bfa7fb3fe3d3846dc9d5f4370652bf6801ef6 --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6c2da08e5b274f0a094ad28afc786b03aa374c37 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,7 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.9611872146118696 1.5306232943330338 0.1258625211882922 0.9991988270496092 0.3032142555899767 3 Q9H3G5,Q9HB40 2 +Histidine acid phosphatase active site [IPR033379] 0.9276165634170273 1.4198634674409558 0.1556474333927198 0.9998724257932904 0.3244334251918345 2 Q9NPH0 1 +Nucleoside diphosphate kinase, active site [IPR023005] 0.8444734268014319 1.0927174670427136 0.2745178682378497 0.9999999589591654 0.481871174921974 2 P22392 1 +Tyrosine-protein kinase, active site [IPR008266] 0.449265905383359 0.2818917001095697 0.7780265539249982 1.0 0.8542025704970991 4 Q15375,Q13308,P07948 3 +Serine/threonine-protein kinase, active site [IPR008271] 0.2950751865943975 0.2457813671018227 0.8058514816010369 1.0 0.8542025704970991 41 Q96GD4,O14976,Q9H2G2,P51812,Q15418,Q9H4A3,Q14004,Q13464,Q14012 9 +Peptidase S9, serine active site [IPR002471] 0.5516791653081095 0.1736539582985999 0.8621374235981618 1.0 0.878716989436588 2 P48147 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bca0140546727f2ac2955a7f21a5c75b458d724d --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MDH1", "MDH2", "MTMR2", "NEK9", "NME1", "NME2", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1", "WNK1"], "leading_proteins": ["ACP6", "AURKB", "CAMK1", "CDK13", "CPVL", "EPHA7", "GAK", "LYN", "NME2", "PREP", "PTK7", "ROCK1", "RPS6KA1", "RPS6KA3", "SCPEP1", "SLK", "WNK1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..66a7dc567824386e01a171c87d164f858703e0b5 --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:acfe4866879b2fd3f0e5ef5d7bf92da60d4dfd26bdf95829ddd2d9460a51ee4b +size 139576 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0032f51496f3d1f76830a0737b7852b0b7b87eab --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b74f54bdc5d81c268495281c571c4b6471506993c9d554e9cb2f1002cc96f580 +size 71165 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3ca4ee0b5f758178cc58034e419d4754fbfa6207 --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 29, + "title": "Average number of proteins per term", + "value": 4.482758620689655 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e5db4a6274f5272d30402aef2741fc3159411150 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7135807904b1f2ddb8c3b5152e3f0ffb6eca7411 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Beta tubulin, autoregulation binding site [IPR013838] 0.7725178511843972 1.7846219961867034 0.074322651093285 0.8935049389928164 0.2155356881705266 5 Q9BVA1,P68371,P07437 3 +Peptidase M16, zinc-binding site [IPR001431] 0.6504264491808454 1.2560342195372989 0.2091035636426177 0.9988896268743824 0.3790002091022446 5 P22695,O43847 2 +EF-Hand 1, calcium-binding site [IPR018247] 0.4066106481550583 1.162263222769659 0.2451285605928523 0.9997127124340036 0.4102972638055564 36 Q9UBV8,Q9Y680,O43852,P41208,P80303,Q13813,O43707,Q02818,Q15293,Q9NWM8,Q14257,Q9BPX6 12 +Hexokinase, binding site [IPR019807] 0.3971307466579725 0.0276452511268541 0.9779450902626964 1.0 1.0 2 P52789 1 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3dc425cc32608126c00d2dd0bd1259d7d89a61ad --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "ARG2", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MCCC1", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1F", "PPM1G", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK4", "TKT", "TLK2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["ACTN4", "CALU", "CETN2", "FKBP14", "FKBP7", "HK2", "MICU1", "NRDC", "NUCB1", "NUCB2", "PEF1", "RCN1", "RCN2", "SPTAN1", "TUBB", "TUBB2B", "TUBB4B", "UQCRC2"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..f8df77ea22b9293f32eed31c6e01485f3fcc2cdb --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Intermediate filament protein, conserved site [IPR018039]", "1": "Proteasome beta-type subunit, conserved site [IPR016050]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..b42b913cccfc8a43a7f11367cf44862949ac7d86 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ba97aa9294266f276f6ec4886fa7a2a872504c5f7d4a868912ab534321deadd9 +size 188417 diff --git a/interpro_conserved_site/advanced/plot_1.png b/interpro_conserved_site/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..f7aff2f65983203a93342de04a92038496df0040 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2906ce366903cd3403e32497ffef9fe8d72fa30aa264084ed443574c551c029a +size 192918 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..f9bdba5f68bc0188662639a204c1322a0a1463e3 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Intermediate filament protein, conserved site [IPR018039]", "1": "Proteasome beta-type subunit, conserved site [IPR016050]", "2": "Guanylate kinase, conserved site [IPR020590]", "3": "Thioredoxin, conserved site [IPR017937]", "4": "14-3-3 protein, conserved site [IPR023409]", "5": "Zinc finger, RING-type, conserved site [IPR017907]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..eee46d929d8554cd10df169b73fb72b54b2afd86 --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:510f6e0ebc9f341c3671471a8eee3d4e838445e250887f9bea9e6db08fad1d94 +size 144766 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..7b02cdbffdd6a54bf6d805f1cccf254604cc16f1 --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2769c0bab7b99ccb83637039bc8817da8a9cd88d79d5c564f96224935421ee3c +size 146849 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..ca9af6f28b5a364e8ed36814a051670d49609509 --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e9f2a5a087ad30729f07a4de90855fb37abf86fa4461ea1a522cc125642fa50a +size 139227 diff --git a/interpro_conserved_site/basic/plot_3.png b/interpro_conserved_site/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..7da38d12ee0cde7dc64a51a481a890faa4cfb9a3 --- /dev/null +++ b/interpro_conserved_site/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2532bcbf02e878cf3bfc331c20f3059173f1d6dbecefb90a4f96696926e2d3a0 +size 138603 diff --git a/interpro_conserved_site/basic/plot_4.png 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/dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:844ba37e20ad500d94eb60a78aa1162bf0a8e6834bcbae50a91c2a9707edde23 +size 95250 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..81632383db8c7871cdcb0705db4015baf422bb6c --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Intermediate filament protein, conserved site [IPR018039] 7 8 2.307912735898728 0.0210039905555499 4.060679611650485 7.546116504854369 0.7869831563787604 0.2926647109331939 1.9153715257926656 0.8924219614624045 1.3691577499316503 0.3120813432784052 0.0281942097886525 1.0 0.1566927560007753 0.0007516413442473 0.0001413957013589 +Proteasome beta-type subunit, conserved site [IPR016050] 6 8 2.264168306331951 0.0235637650953388 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 0.0089540270958906 1.0 1.0 5.99954180608972e-05 5.383729574080712e-05 +Annexin repeat, conserved site [IPR018252] 3 6 2.111824727324483 0.0347014855568634 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 1.0 1.0 0.0003260526470588 +ABC transporter-like, conserved site [IPR017871] 3 10 1.961268907421968 0.0498476623180239 2.7694174757281553 10.218446601941748 0.3896442308636141 0.4819689640161482 2.0043003889175366 2.2319066503087304 0.948959154182388 0.2971074262916467 0.0409762817664239 1.0 0.1880666528119386 0.0016666756698247 0.0198699646710478 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..df0d10a3984e280be8df7298abf39d6a87daaba2 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 271, + "title": "Average number of proteins per term", + "value": 2.7232472324723247 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0d2f3bc3b553a2c8ec81a1486224440fa31ae61f --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b57ea38b550ec503caa25a332d53283dec07c679 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,25 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Intermediate filament protein, conserved site [IPR018039] 0.7935315256452342 2.307912735898728 0.0210039905555499 0.9968258332391036 0.1515164773184385 8 P20700,P02545,P07196,P08670,Q16352,Q03252,P07197 7 +Proteasome beta-type subunit, conserved site [IPR016050] 0.7840155666177615 2.264168306331951 0.0235637650953388 0.998438674357442 0.1515164773184385 8 P28070,P49720,Q99436,P28072,P49721,P28074 6 +Annexin repeat, conserved site [IPR018252] 0.8120931525833728 2.111824727324483 0.0347014855568634 0.999930288592488 0.1679304033198214 6 P08133,P09525,P20073 3 +ABC transporter-like, conserved site [IPR017871] 0.6772848758386246 1.961268907421968 0.0498476623180239 0.9999990406692536 0.1986575954144778 10 Q03519,O15439,P08183 3 +Guanylate kinase, conserved site [IPR020590] 0.7021554539516758 1.7982297696928864 0.0721406038120267 0.9999999984594772 0.2443762954132404 7 Q00013,Q9NZW5,Q92796,O14936,Q12959,Q14168 6 +Tubulin, conserved site [IPR017975] 0.7725178511843972 1.7846219961867034 0.074322651093285 0.9999999991861178 0.2456272981253689 5 Q9BVA1,P68371,P07437 3 +Mini-chromosome maintenance, conserved site [IPR018525] 0.7086236592656661 1.6557731326971512 0.0977677706555146 0.9999999999992216 0.2965574453434739 6 P33991 1 +Haem oxygenase conserved site [IPR018207] 0.9863058363221396 1.6522298061110303 0.0984877124756924 0.999999999999373 0.2965574453434739 2 P30519 1 +Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.6559104076384878 1.5790352200577125 0.1143279787941122 0.9999999999999948 0.3194111572495302 7 O94788 1 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.7115059100900154 1.2663948797840072 0.2053717431430231 1.0 0.4561946097685185 4 Q8N4Q0 1 +Aldehyde dehydrogenase, glutamic acid active site [IPR029510] 0.5819262066701292 1.221208383512514 0.2220071308452385 1.0 0.4851930037020938 7 O94788 1 +Thioredoxin, conserved site [IPR017937] 0.5009100202077782 1.1155278119056786 0.2646243071508194 1.0 0.5470558758416095 11 Q96JJ7,Q9H3N1,Q8IXB1,Q9H1E5,O95881 5 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.6737357259379907 1.1112456174483647 0.2664626406313375 1.0 0.5470558758416095 4 P50213,P48735,O75874 3 +Syntaxin/epimorphin, conserved site [IPR006012] 0.5498880635984178 1.0649611898005291 0.2868934928497864 1.0 0.5614909444154608 7 Q86Y82,Q9P2W9 2 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.8079556569938224 0.9520280386540244 0.3410827621946355 1.0 0.620358580904337 2 Q9BTY2 1 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.779343595253533 0.8686719441416817 0.3850265911688755 1.0 0.6675084443004035 3 P55899 1 +Ubiquitin interacting motif [IPR003903] 0.5202459771512052 0.6940842860118729 0.4876293525989466 1.0 0.7424019918781715 5 P42566,O14964,Q92783 3 +14-3-3 protein, conserved site [IPR023409] 0.4436826640548437 0.4661902708445656 0.641079312747538 1.0 0.8285372376831751 6 P63104,P31946,P61981,P27348,P62258 5 +Zinc finger, RING-type, conserved site [IPR017907] 0.3142676215677434 0.2063529070133513 0.8365152538801166 1.0 0.940645783408762 13 O75150,O15344,Q5VTR2,P19474,Q9UPN9 5 +Lysosome-associated membrane glycoprotein, conserved site [IPR018134] 0.5330942288881558 0.1423643227584059 0.8867922416195688 1.0 0.967313395334085 2 P11279 1 +D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752] 0.4519074013694127 0.0531029057190117 0.9576499162925622 1.0 1.0 2 O43175 1 +Actin, conserved site [IPR004001] 0.4343006194978734 0.042522530558495 0.9660821512035982 1.0 1.0 2 P61163 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.3472448646886206 0.0185653998112651 0.9851878050269348 1.0 1.0 2 Q16836 1 +Acyl-CoA-binding protein, ACBP, conserved site [IPR022408] 0.3171426014948582 0.0004917114475792 0.999607671043416 1.0 1.0 3 Q9H3P7 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f21e79b863c271fb7b8b907c2b7863279a39b8e3 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3'5'-cyclic nucleotide phosphodiesterase, conserved site [IPR023174]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ephrin, conserved site [IPR019765]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7B", "ATR", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCR", "BCS1L", "BDH2", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD3", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG1", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFNB1", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK1", "FOXO3", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPAD1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NFKB2", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSD3", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDE8A", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF2", "PHF3", "PHGDH", "PHIP", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RIOK2", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLC5A6", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIM4", "TRIP13", "TRMT11", "TSFM", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR7", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", 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a/interpro_domain/basic/plot_9.png b/interpro_domain/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..c8f847e7cba3fcaf62ddfae0b1fc8bd3dcdbffce --- /dev/null +++ b/interpro_domain/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:327cc5b5700ba557bb8f8c4dfa2a36285a0216d3da8c04a322e2728df68e2abf +size 134907 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..137d409dae5b9b1df7e8e57b81c9089d17a0835b --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ce545f8e281b0da4517b1fb4e680ff1a6e40f8135b95e3ab9300b5c5a7a57773 +size 277797 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e39e7fe097b19c4a0f198c2e107dd2691f060d2f --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Zinc finger, RanBP2-type [IPR001876] 3 8 2.4078012130852677 0.0160489169963775 3.2742718446601944 8.616504854368932 0.6239078002715212 0.4100405386528319 1.463145369641179 0.7330740021954685 1.0299872364022182 0.3121093098016552 0.2676873295985275 1.0 1.0 0.0889449047367856 0.0168879338153791 +ABC transporter type 1, transmembrane domain [IPR011527] 3 6 2.3394416360877552 0.0193125888198713 2.3689320388349513 6.349514563106796 0.6640264147492347 0.3307390797434538 1.7803691733569 2.1393617497725477 1.1694677427725269 0.279101120079799 0.0199123159742315 1.0 0.1323778037089543 0.0003547957514141 0.0048470794580564 +Intermediate filament, rod domain [IPR039008] 7 8 2.307912735898728 0.0210039905555499 4.060679611650485 7.546116504854369 0.7869831563787604 0.2926647109331939 1.9153715257926656 0.8924219614624045 1.3691577499316503 0.3120813432784052 0.0409762817664239 1.0 0.1880666528119386 0.0016666756698247 0.0004815297744428 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 3 6 2.0699245136455207 0.0384594139474299 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0006228809854352 0.0550816697898294 0.0001673348473236 0.0025378182642571 0.0019736987849612 +Major facilitator superfamily domain [IPR020846] 2 5 2.0231649868182657 0.0430561402148614 1.8883495145631068 4.121359223300971 0.8776223597987594 0.2728824130413255 1.233496960525634 1.4580976091979958 1.2936014196902064 0.266909732326598 0.0094731611073946 0.1321770275159086 0.0321664764057317 0.0341659855040389 0.175898786896668 +MHC class I-like antigen recognition-like [IPR011161] 3 5 1.9623191820198955 0.0497253353198345 1.6286407766990292 3.3519417475728157 0.7088257141352072 0.3792248400111384 0.978137271268229 0.8617667089672962 1.1217132539816763 0.2987888107271844 1.0 1.0 1.0 0.2877500137996227 0.0276005264132961 +ABC transporter-like, ATP-binding domain [IPR003439] 3 10 1.961268907421968 0.0498476623180239 2.7694174757281553 10.218446601941748 0.3896442308636141 0.4819689640161482 2.0043003889175366 2.2319066503087304 0.948959154182388 0.2971074262916467 0.0480381407843038 1.0 0.2033176172301104 0.0023319502763363 0.0267540631687978 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5a102052343031abf81a9682121749ce58bf8140 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 2558, + "title": "Average number of proteins per term", + "value": 2.168491008600469 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..90ed1de96c365fa68853972dfe988f5865853db2 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..548dc72724cf17de85c7a23f8f464d97d64f7808 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,198 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Zinc finger, RanBP2-type [IPR001876] 0.8154463262523648 2.4078012130852673 0.0160489169963775 1.0 0.1931193146782799 8 P98175,Q92804,P35637 3 +ABC transporter type 1, transmembrane domain [IPR011527] 0.8656257633459856 2.3394416360877552 0.0193125888198713 1.0 0.1933360414939776 6 O15439,Q03519,P08183 3 +Intermediate filament, rod domain [IPR039008] 0.7935315256452342 2.307912735898728 0.0210039905555499 1.0 0.1949931601949367 8 P20700,P02545,P07196,P08670,Q16352,Q03252,P07197 7 +Intermediate filament head, DNA-binding domain [IPR006821] 0.9305057096247924 2.1476148398245924 0.0317443655483109 1.0 0.2148203361708449 4 P07196,Q16352,P08670 3 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.8023863014909101 2.0699245136455207 0.0384594139474299 1.0 0.2277295853646428 6 Q8WUJ1,O43169,Q9UMX5 3 +ERAP1-like C-terminal domain [IPR024571] 0.902992129375616 2.0401822957390556 0.0413321724203092 1.0 0.2348090909462638 4 P55786 1 +Major facilitator superfamily domain [IPR020846] 0.8292421757829933 2.0231649868182657 0.0430561402148614 1.0 0.2377010298297014 5 Q6NT16,P53985 2 +MHC class I-like antigen recognition-like [IPR011161] 0.8146489134597705 1.9623191820198953 0.0497253353198345 1.0 0.2508760130887894 5 Q9UNN8,P10321,P55899 3 +ABC transporter-like, ATP-binding domain [IPR003439] 0.6772848758386246 1.961268907421968 0.0498476623180239 1.0 0.2508760130887894 10 Q03519,O15439,P08183 3 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.811791978789639 1.95036390939213 0.0511327602837279 1.0 0.2530390330497927 5 P35670,Q9HD20 2 +Guanylate kinase-like domain [IPR008144] 0.6918300653594781 1.9156745762424112 0.0554065304691422 1.0 0.2592895277235573 9 Q00013,Q9NZW5,Q92796,O14936,Q9UDY2,Q12959,Q5T2T1,Q14168 8 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.6918300653594781 1.9156745762424112 0.0554065304691422 1.0 0.2592895277235573 9 Q00013,Q9NZW5,Q92796,O14936,Q9UDY2,Q12959,Q5T2T1,Q14168 8 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.7530118380804741 1.853894571404372 0.0637542447133148 1.0 0.2735413401597846 6 Q9UIQ6,P55786 2 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.7530118380804741 1.853894571404372 0.0637542447133148 1.0 0.2735413401597846 6 Q9UIQ6,P55786 2 +FAD dependent oxidoreductase [IPR006076] 0.8536071210189589 1.8445763690852648 0.0650991871511976 1.0 0.2746087859387314 4 Q96CU9 1 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.2961329306800984 5 Q9BVA1,P68371,P07437 3 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.2961329306800984 5 Q9BVA1,P68371,P07437 3 +Protein kinase, C-terminal [IPR017892] 0.6968841048803629 1.7734604812706871 0.0761524347026925 1.0 0.2996493464459994 7 Q15418 1 +GMP phosphodiesterase, delta subunit [IPR008015] 0.9931529181610694 1.6792815501787255 0.0930971849672446 1.0 0.3378287841461851 2 O43924 1 +K Homology domain, type 1 [IPR004088] 0.4834108433151611 1.6660966189679056 0.0956941718605315 1.0 0.344341359786144 23 P51114,Q96I24,Q92945,Q96AE4,Q13868,P61978,Q96PU8,Q9Y2W6,Q9Y6M1,Q9NQT5,O75525 11 +B-box-type zinc finger [IPR000315] 0.6740411673949309 1.6654683665286811 0.0958193496545614 1.0 0.344341359786144 7 O15344,Q9UPN9 2 +RNA recognition motif domain [IPR000504] 0.4167114579639629 1.6604449478878025 0.0968249742010711 1.0 0.3459193910703073 120 P84103,P52272,P52597,Q13243,P62995,Q8WVV9,Q96I25,Q96PK6,O60506,Q8WUA2,P98175,Q5T8P6,Q96EP5,P08621,P31943,Q9UHX1,P23588,Q12849,Q13242,Q9BWF3,P35637,Q9Y5S9,P43243,O14979,Q8WXF1,Q96E39,P98179,P51991,P55795,Q9UKA9,Q96T37,Q13151,P09651,P38159,O95104,P31942,Q99729,Q86U42,O43390,Q07955,P23246,P22626,Q15233,Q8IY67,Q14103,Q92804,Q16629,Q01085,Q8N684,P07910,Q14011,Q9Y6M1,Q76FK4,O75494,Q9P2N5,Q01844,P18615 57 +MCM N-terminal domain [IPR027925] 0.7086236592656661 1.6557731326971512 0.0977677706555146 1.0 0.3473471629677868 6 P33991 1 +MCM OB domain [IPR033762] 0.7086236592656661 1.6557731326971512 0.0977677706555146 1.0 0.3473471629677868 6 P33991 1 +MCM, AAA-lid domain [IPR041562] 0.7086236592656661 1.6557731326971512 0.0977677706555146 1.0 0.3473471629677868 6 P33991 1 +MCM domain [IPR001208] 0.7086236592656661 1.6557731326971512 0.0977677706555146 1.0 0.3473471629677868 6 P33991 1 +Immunoglobulin C1-set [IPR003597] 0.8008712411434151 1.632152094535959 0.1026474497238472 1.0 0.3557888569018986 4 P10321,P55899 2 +Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906] 0.973915878708837 1.6032313043097166 0.1088835965673296 1.0 0.3689062781711644 2 Q15418 1 +L27 domain [IPR004172] 0.7276365105867804 1.5922825848923488 0.1113212241826504 1.0 0.3756724161731132 5 Q14168,Q12959,O14936 3 +Cyclic nucleotide-binding domain [IPR000595] 0.7122685089501921 1.525799788495978 0.1270597334034542 1.0 0.4067819750263277 5 Q6P4Q7,Q8TEU7 2 +EF-hand domain [IPR002048] 0.4321433280886074 1.450594841024568 0.1468927127030306 1.0 0.4425813416894609 41 Q9UBV8,Q8NF37,Q9Y680,P60660,O43852,Q8IYU8,P41208,P80303,Q13813,O43707,Q02818,Q15293,Q9NWM8,Q14257,Q9BPX6 15 +Zinc finger, CHHC-type [IPR012996] 0.9367253750815376 1.4407418820578124 0.1496576179433104 1.0 0.4457644456778711 3 P31943,P52597 2 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.6559941705137533 1.416816500534899 0.1565365841495658 1.0 0.452113183538478 6 O15460,Q32P28 2 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.6559941705137533 1.416816500534899 0.1565365841495658 1.0 0.452113183538478 6 O15460,Q32P28 2 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9090019569471576 1.338789937993523 0.1806390673462934 1.0 0.4893273782840405 3 Q96G23,Q15629 2 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.9021845451581432 1.3192455163551975 0.1870870459772768 1.0 0.499852312008928 2 O15254 1 +AGC-kinase, C-terminal [IPR000961] 0.5555913693274626 1.316351044493892 0.1880562456900403 1.0 0.5005319416428902 10 Q15418 1 +RBM3/CIRBP, RNA recognition motif [IPR034278] 0.8976198239321888 1.3012167831494776 0.1931842621080559 1.0 0.5083528139349434 2 Q14011 1 +Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219] 0.584898779131887 1.30067622399392 0.1933693039237449 1.0 0.5083528139349434 8 O75116,P05771,Q13464,Q9H0H5 4 +Extended PHD (ePHD) domain [IPR034732] 0.7196755943190272 1.2999865055108726 0.1936055942749934 1.0 0.5083528139349434 4 Q03164 1 +Peptidase M16, N-terminal [IPR011765] 0.5967093441352611 1.2931930499288693 0.1959442988266631 1.0 0.5088583922828469 7 P22695,Q5JRX3,O43847 3 +Peptidase M16, C-terminal [IPR007863] 0.5967093441352611 1.2931930499288693 0.1959442988266631 1.0 0.5088583922828469 7 P22695,Q5JRX3,O43847 3 +MRH domain [IPR044865] 0.8953836394535422 1.2887379392083185 0.1974892080573425 1.0 0.5107961518813772 3 P20645 1 +Metaxin, glutathione S-transferase domain [IPR033468] 0.8920417482061256 1.2764631051084547 0.2017918610418061 1.0 0.5177367909176931 3 Q5HYI7,Q13505 2 +Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.8920417482061256 1.2764631051084547 0.2017918610418061 1.0 0.5177367909176931 3 Q5HYI7,Q13505 2 +NOPS [IPR012975] 0.8864970645792518 1.2561064492443872 0.209077378197624 1.0 0.52795649894326 3 P23246,Q8WXF1 2 +L27 domain, C-terminal [IPR014775] 0.7029088272825322 1.2310454641875772 0.218305860682441 1.0 0.5433386411690145 4 Q14168,O14936 2 +Rho GTPase-activating protein domain [IPR000198] 0.6408761595309505 1.2141964128900875 0.2246727299804978 1.0 0.5531403689029003 5 O00459,Q9H0H5 2 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.8734507501630722 1.2082650422204888 0.2269453303707784 1.0 0.5540319217393016 3 Q9ULX6,O43823 2 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.5353603392296753 1.2064536013601246 0.2276426391378307 1.0 0.5540319217393016 10 Q9Y680,Q9NWM8 2 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.6965692515191306 1.2049846085977929 0.2282092437102709 1.0 0.5543772511024436 4 Q8WVV9 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.4725473994054073 1.1981024449038955 0.2308771371645195 1.0 0.555542228422532 14 P38159,Q14011 2 +B-box, C-terminal [IPR003649] 0.6930657740103074 1.190586674789857 0.2338158852874001 1.0 0.5563730554094601 4 O15344 1 +PDZ domain [IPR001478] 0.4191644793250441 1.1723373046298686 0.2410616599320474 1.0 0.5616018049451642 23 Q00013,P57105,Q9NZW5,Q92796,Q9Y4G8,O14936,Q96HC4,Q9UDY2,Q12959,Q8TEU7,Q5T2T1,Q14168 12 +Far upstream element-binding protein, C-terminal [IPR015096] 0.8630583632213903 1.1652546953145555 0.2439159117682927 1.0 0.5616018049451642 2 Q92945 1 +Dynamin, N-terminal [IPR045063] 0.5435501434094816 1.1576932029541993 0.2469892587335871 1.0 0.5625099502662559 9 Q8IWA4 1 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.5435501434094816 1.1576932029541993 0.2469892587335871 1.0 0.5625099502662559 9 Q8IWA4 1 +LEM domain [IPR003887] 0.591225730094034 1.1191271485234142 0.263085899346851 1.0 0.5763372934510959 6 Q86XL3 1 +Isopropylmalate dehydrogenase-like domain [IPR024084] 0.6737357259379907 1.1112456174483647 0.2664626406313375 1.0 0.5786175167529384 4 P50213,P48735,O75874 3 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.8480599934789671 1.1066753803706304 0.2684343034040373 1.0 0.5805342982324583 2 O60506 1 +Aldehyde dehydrogenase domain [IPR015590] 0.5327288564677426 1.1012220073682566 0.2708000457848114 1.0 0.5825958932864151 9 O94788 1 +Nucleoside diphosphate kinase-like domain [IPR034907] 0.8444734268014319 1.0927174670427136 0.2745178682378497 1.0 0.5833519734421355 2 P22392 1 +CARG-binding factor, N-terminal [IPR012956] 0.8431692207368731 1.0876471453474197 0.276750909353068 1.0 0.5835264229489241 2 Q99729 1 +Disks large homologue 1, N-terminal PEST domain [IPR019590] 0.8382784479947795 1.0686597051530065 0.2852230346771489 1.0 0.5941372334724324 2 Q92796 1 +PDZ-associated domain of NMDA receptors [IPR019583] 0.8382784479947795 1.0686597051530065 0.2852230346771489 1.0 0.5941372334724324 2 Q92796 1 +Lamin tail domain [IPR001322] 0.8326810176125174 1.0595995895039187 0.2893268004432439 1.0 0.5992607392736308 3 P02545,Q03252 2 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8323548597521138 1.058417412561123 0.289865184430405 1.0 0.5992607392736308 3 O15460,Q32P28 2 +Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.8320834691881305 1.0446719379083094 0.2961746187958791 1.0 0.6031963971973399 2 O15460 1 +Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375] 0.6555906815545606 1.0370244215157634 0.2997244758081834 1.0 0.6065626654409282 4 Q4J6C6 1 +EF-hand, Ca insensitive [IPR014837] 0.8245270711024077 1.0300888564903112 0.302968295802881 1.0 0.6068812274657805 3 O43707,Q13813 2 +UBX domain [IPR001012] 0.5683653581231906 1.014025549774808 0.3105705609494373 1.0 0.613257188184058 6 Q9UNZ2,Q96CS3,O94888,Q9UNN5 4 +ENTH domain [IPR013809] 0.6485340930159088 1.0082598913872378 0.3133297125163106 1.0 0.613257188184058 4 O00291 1 +Ion transporter-like, CBS domain [IPR044751] 0.8187153570264178 0.9931758208502024 0.3206242793581406 1.0 0.6168902285942914 2 Q6P4Q7 1 +CNNM, transmembrane domain [IPR002550] 0.8187153570264178 0.9931758208502024 0.3206242793581406 1.0 0.6168902285942914 2 Q6P4Q7 1 +K Homology domain [IPR004087] 0.4010740310014128 0.9834684052310182 0.3253769578249388 1.0 0.6180681104422899 22 P51114,Q96I24,Q92945,Q96AE4,P61978,Q96PU8,Q9Y2W6,Q9Y6M1,O75525 9 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.8079556569938224 0.9520280386540244 0.3410827621946355 1.0 0.6322389171694767 2 Q9BTY2 1 +Sam68, tyrosine-rich domain [IPR032335] 0.8033909357678517 0.9346618348394988 0.3499626012895152 1.0 0.6408048203998423 2 O75525 1 +KHDRBS, Qua1 domain [IPR032571] 0.8033909357678517 0.9346618348394988 0.3499626012895152 1.0 0.6408048203998423 2 O75525 1 +Peptidase M28 [IPR007484] 0.7930102958914446 0.9170529662167002 0.3591148857286295 1.0 0.6487400266199395 3 Q7Z2K6 1 +Class II aldolase/adducin N-terminal [IPR001303] 0.7939354417997999 0.8988768697839119 0.368718249519093 1.0 0.6581070833018049 2 P35611 1 +RING-type zinc-finger, LisH dimerisation motif [IPR027370] 0.7936093902836621 0.8976476642702095 0.3693734192943163 1.0 0.6581951899972378 2 O15344 1 +EGF-like domain [IPR000742] 0.7872427244735163 0.8965815348856525 0.3699422548047417 1.0 0.6581951899972378 3 Q07954 1 +Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019] 0.7851320508640566 0.8658070270330431 0.3865959949927564 1.0 0.6742521845527775 2 P06865 1 +Glycoside hydrolase family 20, catalytic domain [IPR015883] 0.7851320508640566 0.8658070270330431 0.3865959949927564 1.0 0.6742521845527775 2 P06865 1 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.7783012165259064 0.8650005814367399 0.387038469657111 1.0 0.6742521845527775 3 P10321 1 +MHC class I, alpha chain, C-terminal [IPR010579] 0.7783012165259064 0.8650005814367399 0.387038469657111 1.0 0.6742521845527775 3 P10321 1 +Ricin B, lectin domain [IPR000772] 0.6106447289519235 0.8553027882899495 0.3923835443378771 1.0 0.678538864702157 4 Q86SF2 1 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.7733202870189047 0.8474965493267086 0.3967184096151508 1.0 0.6815350515752558 3 Q06323,Q9UL46 2 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.7733202870189047 0.8474965493267086 0.3967184096151508 1.0 0.6815350515752558 3 Q06323,Q9UL46 2 +RBM1CTR [IPR012604] 0.7740462993153092 0.8245384892587662 0.4096336554992053 1.0 0.6911341196313553 2 P38159 1 +Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091] 0.4642130935396291 0.8203993745033209 0.4119884719453117 1.0 0.6916319267526486 10 P16219,O15254 2 +Importin-alpha, importin-beta-binding domain [IPR002652] 0.5491297275669855 0.8156211684996201 0.4147168384863049 1.0 0.6916319267526486 5 P52292 1 +HD/PDEase domain [IPR003607] 0.7694815780893578 0.8076772152078866 0.4192764234007085 1.0 0.6919363630851815 2 O60658 1 +Glycosyl transferase, family 1 [IPR001296] 0.7632865992826872 0.7849257166013267 0.432497123084945 1.0 0.701094829436812 2 Q2TAA5 1 +Plectin/S10, N-terminal [IPR005326] 0.7613302901858694 0.7777737969328044 0.4367023779510015 1.0 0.7056757313952381 2 P46783 1 +AP180 N-terminal homology (ANTH) domain [IPR011417] 0.7606781871535857 0.7753934136695739 0.4381072258153551 1.0 0.706383713679933 2 O00291 1 +Brdt, bromodomain, repeat I [IPR043508] 0.7600260841212896 0.7730148432073972 0.43951359621067 1.0 0.706383713679933 2 P25440 1 +NET domain [IPR027353] 0.7600260841212896 0.7730148432073972 0.43951359621067 1.0 0.706383713679933 2 P25440 1 +Brdt, bromodomain, repeat II [IPR043509] 0.7600260841212896 0.7730148432073972 0.43951359621067 1.0 0.706383713679933 2 P25440 1 +LIS1 homology motif [IPR006594] 0.5121424414172694 0.7589550284380212 0.4478794591888839 1.0 0.7102762905177713 6 O95684,Q14978 2 +Arfaptin homology (AH) domain [IPR010504] 0.7469840234757107 0.7258409143400318 0.4679363016421383 1.0 0.7229301079883454 2 P53367 1 +Zinc finger, C3HC4 RING-type [IPR018957] 0.7333758266159234 0.7098779921254685 0.4777797990495671 1.0 0.7323211440549618 3 O75150 1 +Ribosome receptor lysine/proline rich [IPR007794] 0.7362243234431005 0.6875346297475139 0.4917458861121986 1.0 0.7443112288017776 2 Q86UP2 1 +Peptidase M41 [IPR000642] 0.7228562112813832 0.640797254291496 0.5216544170811588 1.0 0.7629456826149824 2 Q9Y4W6 1 +Amine oxidase [IPR002937] 0.7094536077665037 0.6303693454276976 0.5284529622105452 1.0 0.7702465397917804 3 Q8NB78 1 +Beta-Casp domain [IPR022712] 0.7189435930877035 0.6273111817400071 0.5304552751998473 1.0 0.7708296643087652 2 Q9UKF6 1 +Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108] 0.7189435930877035 0.6273111817400071 0.5304552751998473 1.0 0.7708296643087652 2 Q9UKF6 1 +ROCK, Rho binding domain [IPR015008] 0.7101402021519345 0.5973093877389558 0.5503008379241905 1.0 0.777623065290683 2 Q13464 1 +GOLD domain [IPR009038] 0.4735027842647347 0.5900725267388223 0.5551420267069456 1.0 0.7823484685652355 6 Q9H3P7,Q9BVK6 2 +Myosin tail [IPR002928] 0.6911007456681226 0.5712269787476636 0.5678457925932494 1.0 0.7877166689010476 3 P35580 1 +STAG [IPR013721] 0.6964460384740814 0.5516441332749562 0.581192192994139 1.0 0.7974723375577466 2 Q8WVM7 1 +Stromalin conservative domain [IPR020839] 0.6964460384740814 0.5516441332749562 0.581192192994139 1.0 0.7974723375577466 2 Q8WVM7 1 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.6944897293772421 0.5452262545583769 0.5855979165841418 1.0 0.7993715345335677 2 Q5T9A4 1 +Ras guanine-nucleotide exchange factors catalytic domain [IPR001895] 0.6938376263449796 0.5430930582063336 0.587065731932426 1.0 0.7993715345335677 2 Q8TEU7 1 +Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651] 0.6938376263449796 0.5430930582063336 0.587065731932426 1.0 0.7993715345335677 2 Q8TEU7 1 +DNA binding HTH domain, Psq-type [IPR007889] 0.6882947505705846 0.5250862331186382 0.5995232459166706 1.0 0.8008836796139089 2 P07199 1 +EH domain [IPR000261] 0.5168026101141795 0.4988200831291764 0.6179061380180217 1.0 0.8103826443077783 4 P42566,Q9H4M9,Q9H223 3 +Zinc finger, CCHC-type [IPR001878] 0.4292123320367306 0.4955036549484317 0.6202446426874642 1.0 0.8115528368258482 7 Q9NUD5,Q16629 2 +Chromo shadow domain [IPR008251] 0.6607958251793769 0.4778012462098691 0.6327916740888238 1.0 0.8200771974308914 3 P45973,Q13185 2 +Chromo domain subgroup [IPR017984] 0.6607958251793769 0.4778012462098691 0.6327916740888238 1.0 0.8200771974308914 3 P45973,Q13185 2 +N-acetylgalactosaminyltransferase [IPR045885] 0.656916432490357 0.4662706237631778 0.6410218031615118 1.0 0.8294794547335369 3 Q86SF2 1 +14-3-3 domain [IPR023410] 0.4436826640548437 0.4661902708445656 0.641079312747538 1.0 0.8294794547335369 6 P63104,P31946,P61981,P27348,P62258 5 +Post-SET domain [IPR003616] 0.4575284440406527 0.4459778561579253 0.6556132415477982 1.0 0.836438240338787 5 Q03164 1 +CYRIA/CYRIB, Rac1 binding domain [IPR009828] 0.6409335077504376 0.4199056589263985 0.6745543736071666 1.0 0.8439701099608125 3 Q96F07 1 +Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187] 0.6540593413759357 0.4192895244206217 0.6750045515162202 1.0 0.8439701099608125 2 O75694 1 +Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585] 0.6514509292468185 0.4116448556562724 0.6805997490747902 1.0 0.8439701099608125 2 Q13243 1 +UAS [IPR006577] 0.6347031963470252 0.402355417180512 0.6874224757583316 1.0 0.8439701099608125 3 Q96CS3,Q9UNN5 2 +Target SNARE coiled-coil homology domain [IPR000727] 0.3898202201073616 0.3861703080076528 0.6993705421778207 1.0 0.8486937471269214 9 P56962,O95721,Q86Y82 3 +GCF, C-terminal [IPR022783] 0.6423214867949096 0.3853923690853854 0.6999467353773581 1.0 0.8489633708370232 2 Q9UBB9 1 +G-patch domain [IPR000467] 0.3391256051424727 0.3756491708043161 0.7071777305085063 1.0 0.8524790926676528 14 Q92917,P98175,Q8IWZ8,Q96I25 4 +SWAP/Surp [IPR000061] 0.4162585700293799 0.3594136784982422 0.719285643471999 1.0 0.8563280340174707 6 Q12872,Q8IWZ8,O15042,Q8IWX8,Q15459 5 +Forkhead-associated (FHA) domain [IPR000253] 0.3833283101843523 0.3572821166133951 0.7208806165622588 1.0 0.8564851914381133 9 P85037 1 +Rhodanese-like domain [IPR001763] 0.4592374702305202 0.3108805780684776 0.755891409854687 1.0 0.860511894262701 4 Q99956 1 +Complex 1 LYR protein domain [IPR008011] 0.6074339745679757 0.2928380785569463 0.7696459209691806 1.0 0.8708701450173642 2 Q9Y6M9 1 +Glycosyltransferase 2-like [IPR001173] 0.4527377847498696 0.2918490431742554 0.7704020456909841 1.0 0.8708701450173642 4 Q86SF2 1 +Alcohol dehydrogenase, N-terminal [IPR013154] 0.3955748047998114 0.2846983766937213 0.7758752344155646 1.0 0.8746975978999623 6 Q8N4Q0 1 +Domain of unknown function DUF5600 [IPR040990] 0.6035213563743079 0.283277896715005 0.7769638195016617 1.0 0.8747682439635787 2 Q9H223 1 +EH domain-containing protein, N-terminal [IPR031692] 0.6035213563743079 0.283277896715005 0.7769638195016617 1.0 0.8747682439635787 2 Q9H223 1 +R3H domain [IPR001374] 0.5877364644487809 0.2807203035843504 0.77892493468619 1.0 0.8765904016398037 3 Q9H6S0,O95453 2 +Phospholipid/glycerol acyltransferase [IPR002123] 0.3868756121449523 0.2550201707500822 0.7987075201804275 1.0 0.8825129810847103 6 O15228,Q92604,Q99943,Q9NUQ2,Q8NF37 5 +Polyketide synthase, enoylreductase domain [IPR020843] 0.3674469501190227 0.2454509048985254 0.8061073177740643 1.0 0.8877752912237566 7 Q8N4Q0 1 +CTP synthase, N-terminal [IPR017456] 0.5862406260189064 0.2431586177918498 0.8078825230931712 1.0 0.8888445135794977 2 Q9NRF8 1 +CTP synthase GATase domain [IPR033828] 0.5862406260189064 0.2431586177918498 0.8078825230931712 1.0 0.8888445135794977 2 Q9NRF8 1 +CBS domain [IPR000644] 0.3790371536061205 0.2292463289012415 0.818677465954232 1.0 0.8971056299239427 6 Q6P4Q7,P51790 2 +Tim44-like domain [IPR007379] 0.5728725138571814 0.2145468101021701 0.8301206675004249 1.0 0.9051358343845212 2 Q9BRJ2 1 +AMP-binding enzyme, C-terminal domain [IPR025110] 0.3847038169628262 0.2058629846677704 0.8368979400659742 1.0 0.9114660007258726 5 P33121,Q9UKU0 2 +Fibronectin type III [IPR003961] 0.364861849727657 0.1851224762692616 0.8531329727768568 1.0 0.9220845430299186 6 O15344,P10586,Q8NAT1 3 +FYVE zinc finger [IPR000306] 0.540641477500844 0.1804310985858092 0.856814141804896 1.0 0.9243907949122412 3 Q7Z3T8 1 +Zinc finger, FYVE-related [IPR017455] 0.540641477500844 0.1804310985858092 0.856814141804896 1.0 0.9243907949122412 3 Q7Z3T8 1 +SH3 domain [IPR001452] 0.2842333924122381 0.1630848991503387 0.8704515893497091 1.0 0.933199985564357 37 Q00013,Q14185,O14936,Q9UDY2,Q5T2T1,Q92796,P46108,O00459,Q9UQB8,Q07157,Q9NZW5,Q14168,Q14247,Q13813,Q96PC5,P62993,Q15149,Q12959,Q92783,Q8N5V2 20 +VHS domain [IPR002014] 0.3934951123763902 0.1439523940074207 0.885538062067291 1.0 0.9465968920886464 4 Q9UJY4,Q92783 2 +Butyrophylin-like, SPRY domain [IPR003879] 0.3538778348069087 0.1271271251983849 0.8988397828318022 1.0 0.9560216900140333 5 O15344 1 +SMARCC, C-terminal [IPR032451] 0.5167916530811804 0.1184140443556004 0.9057395982838768 1.0 0.960963041231919 2 Q8TAQ2 1 +SMARCC, SWIRM-associated domain [IPR032448] 0.5167916530811804 0.1184140443556004 0.9057395982838768 1.0 0.960963041231919 2 Q8TAQ2 1 +SMARCC, N-terminal [IPR032450] 0.5167916530811804 0.1184140443556004 0.9057395982838768 1.0 0.960963041231919 2 Q8TAQ2 1 +ZU5 domain [IPR000906] 0.5154874470166171 0.1166371314079278 0.9071476119240554 1.0 0.9617225359671197 2 Q07157 1 +MOSC, N-terminal beta barrel [IPR005303] 0.5040756439517322 0.1019511040586566 0.918795486077978 1.0 0.96977661217635 2 Q5VT66 1 +Molybdenum cofactor sulfurase, C-terminal [IPR005302] 0.5040756439517322 0.1019511040586566 0.918795486077978 1.0 0.96977661217635 2 Q5VT66 1 +PITH domain [IPR010400] 0.5024453863710346 0.0999778488425663 0.9203619113821636 1.0 0.970839492501268 2 O43396 1 +Endonuclease/exonuclease/phosphatase [IPR005135] 0.4859752120025872 0.0944747513072598 0.9247320382607134 1.0 0.9732502255521348 3 Q6L8Q7,P27695 2 +Protein-tyrosine phosphatase, catalytic [IPR003595] 0.3346054066845283 0.0860995780087788 0.9313872590805464 1.0 0.9796416976677788 5 P10586,Q13614,P18031 3 +PABP, RNA recognition motif 2 [IPR045305] 0.484512552983358 0.0802643555141828 0.9360270068961732 1.0 0.981636452350767 2 Q13310 1 +ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728] 0.4828822954026716 0.0786485725558616 0.9373121518513 1.0 0.9816458452359934 2 Q14240 1 +SPRY-associated [IPR006574] 0.3565195042763166 0.0775076034760088 0.9382197427725808 1.0 0.9819828567971612 4 O15344 1 +Heat shock chaperonin-binding [IPR006636] 0.4690150032615688 0.0744883999840206 0.9406217709966476 1.0 0.9832738592718911 3 P31948,Q9NRR5 2 +PWI domain [IPR002483] 0.3280026109660646 0.0735415661110186 0.9413751686305168 1.0 0.9832738592718911 5 Q9P2N5,P49756,Q5T8P6,O43395 4 +Diacylglycerol/phorbol-ester binding [IPR020454] 0.452945364066878 0.0583106845012545 0.953501156996298 1.0 0.9943155155305872 3 P05771 1 +Tyrosine-protein kinase, catalytic domain [IPR020635] 0.4491193737769033 0.0548380585170677 0.9562674796940058 1.0 0.9959821714402552 3 Q15375,P07948 2 +CTLH, C-terminal LisH motif [IPR006595] 0.4408216498206596 0.0461404631018677 0.9631982954436068 1.0 0.9995380282940146 2 Q96S59 1 +Immunoglobulin subtype 2 [IPR003598] 0.2978445460483318 0.0389070120985715 0.9689645259574358 1.0 1.0 7 P10586,Q13308,P35613,Q13740,Q9Y624,Q9BX67 6 +Reticulon [IPR003388] 0.4289565892446031 0.0388054043439139 0.969045536038302 1.0 1.0 3 O95197 1 +RasGAP protein, C-terminal [IPR000593] 0.4202804043038766 0.0358391254650334 0.9714106354841924 1.0 1.0 2 Q13576 1 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.4182682310581953 0.0317576772818855 0.974665298233912 1.0 1.0 3 P31689 1 +Clp ATPase, C-terminal [IPR019489] 0.4088686012389847 0.0313964543269528 0.9749533687961124 1.0 1.0 2 Q9H078 1 +GRAM domain [IPR004182] 0.4168297455968648 0.0308809154343861 0.975364509941244 1.0 1.0 3 Q969T9,Q13614 2 +Ribosomal protein S10 domain [IPR027486] 0.4062601891098754 0.0304949058732429 0.9756723560176668 1.0 1.0 2 P82664 1 +Hexokinase, N-terminal [IPR022672] 0.3971307466579725 0.0276452511268541 0.9779450902626964 1.0 1.0 2 P52789 1 +Hexokinase, C-terminal [IPR022673] 0.3971307466579725 0.0276452511268541 0.9779450902626964 1.0 1.0 2 P52789 1 +Arf GTPase activating protein [IPR001164] 0.4011741682974371 0.0223684982162903 0.9821540088433748 1.0 1.0 3 Q8N6T3,Q8N6H7 2 +Protein kinase domain [IPR000719] 0.2581929176276266 0.0193305755347811 0.9845773927325794 1.0 1.0 50 Q96GD4,O14976,O14936,Q9H2G2,P51812,Q15418,Q9H4A3,Q14004,Q13464,Q14012 10 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.3472448646886206 0.0185653998112651 0.9851878050269348 1.0 1.0 2 Q16836 1 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.3472448646886206 0.0185653998112651 0.9851878050269348 1.0 1.0 2 Q16836 1 +Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164] 0.3469188131724842 0.0185328470810819 0.9852137738798232 1.0 1.0 2 Q5JTZ9 1 +Extended synaptotagmin, C2B domain [IPR037749] 0.344310401043368 0.0182815343249486 0.985414258479906 1.0 1.0 2 A0FGR8 1 +Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468] 0.344310401043368 0.0182815343249486 0.985414258479906 1.0 1.0 2 A0FGR8 1 +Extended synaptotagmin, C2A domain [IPR037733] 0.344310401043368 0.0182815343249486 0.985414258479906 1.0 1.0 2 A0FGR8 1 +Extended synaptotagmin, C-terminal C2 domain [IPR037752] 0.344310401043368 0.0182815343249486 0.985414258479906 1.0 1.0 2 A0FGR8 1 +Synaptotagmin, SMP domain [IPR039010] 0.344310401043368 0.0182815343249486 0.985414258479906 1.0 1.0 2 A0FGR8 1 +Acyltransferase, C-terminal domain [IPR032098] 0.3864970645792563 0.0159607108596144 0.9872657358914844 1.0 1.0 3 Q9NUQ2,Q92604 2 +Bms1/Tsr1-type G domain [IPR030387] 0.3025758069775029 0.0159252384898663 0.9872940351508804 1.0 1.0 2 Q2NL82 1 +Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034] 0.3025758069775029 0.0159252384898663 0.9872940351508804 1.0 1.0 2 Q2NL82 1 +AARP2CN [IPR012948] 0.3025758069775029 0.0159252384898663 0.9872940351508804 1.0 1.0 2 Q2NL82 1 +DZF domain [IPR006561] 0.3021207177814028 0.0158357420292679 0.9873654339914112 1.0 1.0 4 Q12906,Q96SI9,Q96KR1 3 +Jumonji, helical domain [IPR041070] 0.2940984675578747 0.0157079777673783 0.9874673624451064 1.0 1.0 2 O75151 1 +JmjC domain [IPR003347] 0.2833823049298146 0.0028582273507706 0.9977194676306772 1.0 1.0 6 O75151,Q9Y2K7,Q8IUF8,P29375,Q9H6W3 5 +La-type HTH domain [IPR006630] 0.2764360313316001 0.0011571781090334 0.999076705658761 1.0 1.0 5 Q6PKG0,Q4G0J3,Q71RC2,Q92615 4 +Acyl-CoA-binding protein, ACBP [IPR000582] 0.3171426014948582 0.0004917114475792 0.999607671043416 1.0 1.0 3 Q9H3P7 1 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2ba38099e072305782c782c843e5936b32b090da --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3'5'-cyclic nucleotide phosphodiesterase, catalytic domain [IPR002073]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-3' exoribonuclease 1, SH3-like domain [IPR041385]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADD domain [IPR025766]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APPL1, BAR domain [IPR037929]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "ATRX, ADD domain [IPR041430]", "AWS domain [IPR006560]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adenomatous polyposis coli protein basic domain [IPR009234]", "Adenomatous polyposis coli, N-terminal dimerisation domain [IPR032038]", "Adenosine deaminase domain [IPR001365]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanine racemase, N-terminal [IPR001608]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-dystroglycan N-terminal domain 2 [IPR041631]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 2, C-terminal [IPR014786]", "Anaphase-promoting complex subunit 4 long domain [IPR024790]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora-A binding [IPR015128]", "B(0)AT2, solute-binding domain [IPR042934]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BCAS3 domain [IPR022175]", "BCNT-C domain [IPR011421]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BR140-related, PWWD domain [IPR035502]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BRPF2, PHD domain [IPR042009]", "BRPF2, ePHD domain [IPR042004]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Bcr-Abl oncoprotein oligomerisation [IPR015123]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCDC93, coiled-coil domain [IPR019159]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMPASS complex Set1 subunit, N-SET domain [IPR024657]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPPED1, metallophosphatase domain [IPR041867]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-binding protein cabin-1, MEF2-binding domain [IPR015134]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carbohydrate kinase, FGGY, N-terminal [IPR018484]", "Carbon-nitrogen hydrolase [IPR003010]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein CENP-B, C-terminal domain [IPR015115]", "Centromere protein Cenp-F, N-terminal [IPR018463]", "Centromere protein Cenp-F, leucine-rich repeat-containing domain [IPR019513]", "Centrosomin, N-terminal motif 1 [IPR012943]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class V myosin, motor domain [IPR036103]", "Class VI myosin, motor domain [IPR036114]", "Classical Protein Kinase C alpha, catalytic domain [IPR034663]", "Classical protein kinase C beta, catalytic domain [IPR034664]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Conserved oligomeric Golgi complex, subunit 4 [IPR013167]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-dependent kinase 11/PITSLRE, catalytic domain [IPR045267]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b-c1 complex subunit Rieske, transmembrane domain [IPR004192]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-glucuronyl C5-epimerase, C-terminal [IPR010598]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAMP1, SANT/Myb-like domain [IPR032563]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DG-type SEA domain [IPR030398]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA binding HTH domain, Psq-type [IPR007889]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA methyltransferase 1-associated 1 [IPR008468]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha, subunit B, N-terminal [IPR013627]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase epsilon subunit B, N-terminal [IPR024639]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor Dna2, N-terminal [IPR014808]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding RFX-type winged-helix domain [IPR003150]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DUS-like, FMN-binding domain [IPR035587]", "DUS2, double-stranded RNA binding domain [IPR044463]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Daxx, N-terminal Rassf1C-interacting domain [IPR031333]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dedicator of cytokinesis, N-terminal domain [IPR032376]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disks Large homologue 3, SH3 domain [IPR035763]", "Disks large homologue 1, N-terminal PEST domain [IPR019590]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF1977, DnaJ-like [IPR015399]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5595 [IPR040967]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "Dystroglycan, C-terminal [IPR008465]", "Dystroglycan-type cadherin-like [IPR006644]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB-1 binding [IPR009232]", "EB1, C-terminal [IPR004953]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enhancer of polycomb-like, N-terminal [IPR019542]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephexin-1, SH3 domain [IPR035635]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin receptor-binding domain [IPR001799]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Ephrin-B ectodomain [IPR034255]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exocyst component Exo84, C-terminal [IPR032403]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease Xrn1, D2/D3 domain [IPR041106]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain [IPR002938]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM3C (ILEI) domain [IPR039475]", "FAM69, protein-kinase domain [IPR022049]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FOXO protein, KIX-binding domain [IPR032068]", "FOXO protein, transactivation domain [IPR032067]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Far11/STRP, C-terminal [IPR021819]", "Far11/STRP, N-terminal [IPR012486]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCF, C-terminal [IPR022783]", "GH15-like domain [IPR011613]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Golgin subfamily A, conserved domain [IPR043976]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase,subfamily IIIA [IPR006549]", "HAT, C-terminal dimerisation domain [IPR008906]", "HAUS augmin-like complex subunit 6, N-terminal [IPR028163]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Heavy metal-associated domain, HMA [IPR006121]", "Heavy metal-associated domain, copper ion-binding [IPR006122]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HhH-GPD domain [IPR003265]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone chaperone domain CHZ [IPR019098]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase complex subunit SAP30 zinc-finger [IPR025717]", "Histone deacetylase complex subunit SAP30, Sin3 binding domain [IPR025718]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Huntingtin-interacting protein 1, clathrin-binding domain [IPR032422]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxyacylglutathione hydrolase, C-terminal domain [IPR032282]", "Hydroxyacylglutathione hydrolase, MBL domain [IPR035680]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "ILEI/PANDER domain [IPR039477]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Initiation factor eIF2 gamma, C-terminal [IPR015256]", "Initiation factor eIF2 gamma, GTP-binding domain [IPR044128]", "Initiation factor eIF2 gamma, domain 2 [IPR044127]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Int12, PHD finger [IPR039054]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain [IPR018302]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "L27-1 [IPR015143]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "LYRM7, LYR domain [IPR045298]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV type B [IPR013015]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "LysM domain [IPR018392]", "Lysine-specific demethylase 4, Tudor domain [IPR040477]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MPP7, SH3 domain [IPR035599]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTF2, PHD domain 1 [IPR042014]", "MTF2, PHD domain 2 [IPR042015]", "MYND-like zinc finger [IPR031615]", "MYST, zinc finger domain [IPR040706]", "Mab-21 domain [IPR024810]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mff-like domain [IPR039433]", "Mib-herc2 [IPR010606]", "Micro-fibrillar-associated protein 1, C-terminal [IPR009730]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mon2, C-terminal [IPR032817]", "Mon2, dimerisation and cyclophilin-binding domain [IPR032629]", "Morc, S5 domain 2-like [IPR041006]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin 5a, cargo-binding domain [IPR037988]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myosin-binding domain [IPR026859]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH dehydrogenase subunit 5, C-terminal [IPR010934]", "NADH pyrophosphatase-like, N-terminal [IPR015375]", "NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal [IPR001516]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit [IPR001750]", "NADH:ubiquinone oxidoreductase intermediate-associated protein 30 [IPR013857]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NEMO, Zinc finger [IPR034735]", "NET domain [IPR027353]", "NF-kappa-B essential modulator NEMO, CC2-LZ domain [IPR032419]", "NF-kappa-B essential modulator NEMO, N-terminal [IPR021063]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NFkappaB IPT domain [IPR033926]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIF system FeS cluster assembly, NifU, C-terminal [IPR001075]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nas2, N-terminal [IPR040815]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nit1/2, carbon-nitrogen hydrolase domain [IPR045254]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Novel protein kinase C delta, catalytic domain [IPR034667]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear hormone receptor, ligand-binding domain [IPR000536]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Olduvai domain [IPR010630]", "Orc1-like, AAA ATPase domain [IPR041664]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAS domain [IPR000014]", "PAS fold [IPR013767]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PDZ-associated domain of NMDA receptors [IPR019583]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI31 proteasome regulator, C-terminal [IPR013886]", "PI3K p85 subunit, C-terminal SH2 domain [IPR035020]", "PI3K p85 subunit, N-terminal SH2 domain [IPR035022]", "PI3K regulatory subunit p85-related , inter-SH2 domain [IPR032498]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PINIT domain [IPR023321]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PKHA4-7, PH domain [IPR040392]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "PNK, FHA domain [IPR041388]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP2B, metallophosphatase domain [IPR041751]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRELI/MSF1 domain [IPR006797]", "PRKCBP1, PHD finger [IPR044075]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Par3/HAL, N-terminal [IPR021922]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase like 2, U-box domain [IPR026951]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain [IPR035586]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain [IPR045583]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Plus-3 domain [IPR004343]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polycomb-like MTF2 factor 2, C-terminal domain [IPR025894]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polynucleotide 3'-phosphatase [IPR006551]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase A anchor protein, nuclear localisation signal domain [IPR019510]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Putative zinc-finger domain [IPR019607]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "Quinolinate phosphoribosyl transferase, C-terminal [IPR002638]", "Quinolinate phosphoribosyl transferase, N-terminal [IPR022412]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RACK7, Bromo domain [IPR037967]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM6, OCRE domain [IPR035617]", "RBM6, RNA recognition motif 1 [IPR034123]", "RBM6, RNA recognition motif 2 [IPR034125]", "RBM8, RNA recognition motif [IPR033744]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RFX1 transcription activation region [IPR007668]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIO kinase [IPR000687]", "RIO2 kinase winged helix domain, N-terminal [IPR015285]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad4 beta-hairpin domain 1 [IPR018326]", "Rad4 beta-hairpin domain 2 [IPR018327]", "Rad4 beta-hairpin domain 3 [IPR018328]", "Rad4/PNGase transglutaminase-like fold [IPR018325]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Raptor, N-terminal CASPase-like domain [IPR029347]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Rel homology dimerisation domain [IPR032397]", "Rel homology domain (RHD), DNA-binding domain [IPR011539]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Retinoblastoma-associated protein, A-box [IPR002720]", "Retinoblastoma-associated protein, B-box [IPR002719]", "Retinoblastoma-associated protein, C-terminal [IPR015030]", "Retinoblastoma-associated protein, N-terminal [IPR024599]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal RNA-processing protein 7, C-terminal domain [IPR024326]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome recycling factor domain [IPR023584]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Rieske iron-sulphur protein, C-terminal [IPR005805]", "RmlD-like substrate binding domain [IPR029903]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rrp7, RRM-like N-terminal domain [IPR040447]", "Rrp7A, RNA recognition motif [IPR034890]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3PXD2, PX domain [IPR037961]", "SH3PXD2B, SH3 domain 1 [IPR035477]", "SH3PXD2B, SH3 domain 2 [IPR035478]", "SH3PXD2B, SH3 domain 3 [IPR035479]", "SH3PXD2B, SH3 domain 4 [IPR035480]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX2, PX domain [IPR037918]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAR protein, homodimerisation region [IPR032377]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Scaffold protein Nfu/NifU, N-terminal [IPR014824]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sde2, N-terminal ubiquitin domain [IPR024974]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec7, C-terminal [IPR015403]", "Sec8 exocyst complex component specific domain [IPR007191]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase Rio2 [IPR030484]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set1A, RNA recognition motif [IPR034467]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Signal transduction histidine kinase-related protein, C-terminal [IPR004358]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin 4, PX domain [IPR034902]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-4, BAR domain [IPR037430]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Sphingolipid delta4-desaturase, N-terminal [IPR013866]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strawberry notch, AAA domain [IPR039187]", "Strawberry notch, helicase C domain [IPR026937]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromal interaction molecule 1, SAM domain [IPR037609]", "Stromal interaction molecule, Orai1-activating region [IPR032393]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfatase-modifying factor enzyme [IPR005532]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Synaptotagmin-like, mitochondrial and lipid-binding domain [IPR040885]", "Syndetin, C-terminal [IPR019514]", "Synembryn [IPR008376]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "Syntrophin, split Pleckstrin homology (PH) domain [IPR041428]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFA2, Winged helix domain 2 [IPR040501]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRIM4, PRY/SPRY domain [IPR035829]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TUG ubiquitin-like domain [IPR021569]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere repeat-binding factor, dimerisation domain [IPR013867]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Telomeric repeat-binding factor 2, Rap1-binding domain [IPR031902]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tex protein, YqgF-like domain [IPR032639]", "Tex, S1 domain [IPR044146]", "Tex-like protein, N-terminal [IPR018974]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor 20, ePHD domain [IPR041972]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFIIE beta subunit, DNA-binding domain [IPR003166]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF-2, domain II [IPR044145]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripartite DENN domain [IPR037516]", "Tripeptidyl-peptidase II domain [IPR034051]", "Trm3/ TARBP1, C-terminal [IPR044748]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase Lyn, SH2 domain [IPR035852]", "Tyrosine-protein kinase Lyn, SH3 domain [IPR035748]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UDP-N-acetylglucosamine 2-epimerase domain [IPR003331]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glycosyltransferase family, conserved site [IPR035595]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UME domain [IPR012993]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "UVR domain [IPR001943]", "Ubiquinol-cytochrome c reductase 8kDa, N-terminal [IPR015248]", "Ubiquinol-cytochrome c reductase, iron-sulphur subunit [IPR006317]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal [IPR032197]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 13D, UBA domain [IPR041969]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Vacuolar protein sorting-associated protein 54, N-terminal [IPR019515]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps72/YL1, C-terminal [IPR013272]", "Vta1, C-terminal [IPR041212]", "Vta1/callose synthase, N-terminal [IPR039431]", "W2 domain [IPR003307]", "WASH complex subunit 4, N-terminal [IPR028191]", "WASH complex subunit 7, C-terminal [IPR028283]", "WASH complex subunit 7, central domain [IPR028282]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "XIAP/BIRC8, UBA domain [IPR042579]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, D1 domain [IPR040992]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "Yip1 domain [IPR006977]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZCRB1, RNA recognition motif [IPR034219]", "ZMYND8/11, PWWP domain [IPR035505]", "ZN598/Hel2, RING finger [IPR041888]", "ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, BED-type [IPR003656]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-like [IPR014857]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc finger, nuclear hormone receptor-type [IPR001628]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc ribbon, NADH pyrophosphatase [IPR015376]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "bMERB domain [IPR022735]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNA/rRNA methyltransferase, SpoU type [IPR001537]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANK3", "ANKLE2", "ANO6", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "APMAP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL5B", "ARL8B", "ARMCX3", "ARMT1", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATP7B", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "BAG3", "BAG5", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCKDHA", "BCKDK", "BCR", "BCS1L", "BIRC6", "BLVRA", "BLVRB", "BMS1", "BOP1", "BPHL", "BPTF", "BRD1", "BRD2", "BRD4", "BRIX1", "BROX", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C1orf35", "C2CD2", "C3orf58", "CABIN1", "CACYBP", "CAD", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARM1", "CARS", "CARS2", "CASK", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC93", "CCNB1", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNPY2", "COA3", "COG4", "COIL", "COLEC12", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "DAG1", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCTN1", "DCUN1D1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "EARS2", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMC1", "EMC7", "EMC8", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM208A", "FAM3C", "FAM49B", "FAM8A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FOXK1", "FOXO3", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GEMIN5", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGB1", "GOPC", "GORASP2", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR89B", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2E2", "GTF3C1", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS6", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "ISOC1", "ISOC2", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "IVD", "IWS1", "JAM3", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1147", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8A", "LRRC8C", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBLAC2", "MCAT", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "METAP1", "METTL13", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MGME1", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF4GD", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL16", "MRPL2", "MRPL24", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL58", "MRPL9", "MRPS10", "MRPS23", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCLN", "NCSTN", "ND5", "NDC80", "NDUFA10", "NDUFA2", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NTHL1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDXK", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POMGNT2", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP3CA", "PPP4C", "PPP5C", "PPWD1", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRELID1", "PREP", "PREPL", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD21", "RAD23B", "RAD50", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RNASEH2A", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRP12", "RRP7A", "RSF1", "RTCA", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHPK", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A2", "SLC27A4", "SLC2A1", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPC25", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STOM", "STOML2", "STRBP", "STRIP1", "STRN", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMM10", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TKT", "TLK2", "TLN1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TP53", "TP53BP1", "TPBG", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT2A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSR1", "TST", "TSTA3", "TTC4", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UGDH", "UGGT1", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP20", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VCP", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13D", "VPS18", "VPS29", "VPS4A", "VPS4B", "VPS50", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WASHC4", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WIZ", "WNK1", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YBX1", "YBX3", "YIPF4", "YKT6", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFC3H1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZNF687", "ZPR1", "ZYX"], "leading_proteins": ["AARS2", "ABCB1", "ABCC4", "ACADS", "ACBD3", "ACOX3", "ACSL1", "ACSL6", "ACTN4", "ADD1", "AFG3L2", "AGPAT1", "AGPAT5", "AKAP8", "AKAP8L", "ALCAM", "ALDH1A2", "ALG11", "ANKLE2", "APEX1", "ARFGAP1", "ARFGAP2", "ARFIP1", "ATAD3B", "ATP13A1", "ATP7B", "AURKB", "BAIAP2", "BRD2", "BSG", "CALU", "CAMK1", "CASK", "CBX3", "CBX5", "CDK13", "CENPB", "CERS2", "CETN2", "CHERP", "CIRBP", "CLCN3", "CLPB", "CNNM4", "CPSF3", "CPSF7", "CRK", "CTPS2", "CTTN", "CYB5B", "CYB5D2", "CYFIP2", "DAZAP1", "DLG1", "DLG3", "DNAJA1", "DOCK1", "DUSP9", "EHD1", "EHD4", "EIF4A2", "EIF4B", "EPHA7", "EPS15", "ERMP1", "ESYT2", "EWSR1", "EXOSC2", "EXOSC3", "F11R", "FAF1", "FAF2", "FCGRT", "FGFR1OP", "FKBP14", "FKBP7", "FOXK1", "FOXRED1", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "GAK", "GALNT7", "GGA2", "GNPAT", "GPKOW", "GRB2", "GRSF1", "HADH", "HEXA", "HIP1", "HK2", "HLA-C", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPLL", "HNRNPM", "HNRNPR", "IDH1", "IDH2", "IDH3A", "IGF2BP2", "ILF3", "INA", "IQGAP2", "JAM3", "KDM1B", "KDM2A", "KDM5A", "KHDRBS3", "KHSRP", "KMT2A", "KPNA2", "KTN1", "LARP1", "LARP4", "LARP4B", "LARP7", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LYN", "M6PR", "MARC1", "MATR3", "MCM4", "MFN1", "MIA2", "MICU1", "MICU2", "MID1", "MPP1", "MPP2", "MPP6", "MPP7", "MRPL45", "MRPS10", "MTMR2", "MTX1", "MTX3", "MYH10", "MYL6", "NDUFB9", "NEFL", "NEFM", "NELFE", "NENF", "NGEF", "NME2", "NOL8", "NOLC1", "NONO", "NPEPPS", "NRDC", "NSFL1C", "NUCB1", "NUCB2", "NUP155", "P3H1", "P4HA2", "PABPC4", "PABPN1", "PARN", "PDE12", "PDE6D", "PDE8A", "PDLIM5", "PEF1", "PHF2", "PIK3R2", "PITRM1", "PLEC", "POMGNT2", "PPIL4", "PREPL", "PRKCB", "PROCR", "PRPF3", "PSME1", "PSME2", "PSPC1", "PTBP2", "PTK7", "PTPN1", "PTPRF", "PUF60", "QKI", "RACGAP1", "RANBP9", "RAPGEF2", "RAPGEF6", "RAVER1", "RBM10", "RBM14", "RBM15", "RBM17", "RBM25", "RBM26", "RBM27", "RBM3", "RBM4", "RBM8A", "RBMX", "RBMXL1", "RCN1", "RCN2", "RIOX1", "RIOX2", "RNF40", "ROCK1", "ROCK2", "RPS10", "RPS6KA1", "RPS6KA3", "RTN3", "SCAF4", "SF3A1", "SFPQ", "SFSWAP", "SLC16A1", "SLC18B1", "SLK", "SMARCC2", "SNAP29", "SNRNP70", "SPTAN1", "SRSF1", "SRSF10", "SRSF3", "SRSF5", "SRSF7", "SRSF9", "STAG1", "STAM", "STIP1", "STRBP", "STX12", "STX17", "SUGP1", "SYNCRIP", "SYNJ2BP", "TAF15", "TAP2", "TDRKH", "TFIP11", "TIAL1", "TJP1", "TJP2", "TMED9", "TRA2B", "TRAM1", "TRIM33", "TSR1", "TUBB", "TUBB2B", "TUBB4B", "TXNL1", "U2SURP", "UBQLN4", "UBXN7", "UQCRC2", "VIM", "WBP2", "WNK1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "YWHAZ", "ZADH2", "ZCCHC3", "ZFR", "ZFYVE16"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..fd09a3b6b2b39745d9faf596deccb20a9bd32593 --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome B-type subunit [IPR023333]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..e0dc09a7fb37b7872bdffc0a9650b84896382f1e --- /dev/null +++ b/interpro_family/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f3c3c359c32a3b33c365bfac20e9bc7f792652cec9f6f4dd2ab1bdd0d138fcbc +size 181624 diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..df39fe10eeb8ea1704121610581835e0c8595b00 --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome B-type subunit [IPR023333]", "1": "14-3-3 protein [IPR000308]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..1c1e1e5c164674191a5f45c1182a564088aa2d2e --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2ad3728c71ff49aeb1031d4af907dc1d56cb0f0afd68dfe67e250e88902c5c0e +size 138432 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..eed2ba54d5d5493ff6363d4e1182c86b8f99f26b --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d03ef34d4fd4c5882582b7440050eb5377131a13fa46238c3d1394a698da940b +size 134721 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5ba95306088bd5815dbac59567653504eeb18cb6 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d13b4d3657990b9cf59e9d071497460ca383f1826440489ea152801ac9dcfafc +size 338930 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f908da0a957f4d16bc88386b5c41178a62c57d39 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome B-type subunit [IPR023333] 6 7 2.2195825890462726 0.0264471152385172 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 0.0072326589819844 1.0 1.0 3.668584180234041e-05 2.80346154767832e-05 +Annexin [IPR001464] 3 6 2.111824727324483 0.0347014855568634 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 1.0 1.0 0.0003260526470588 +Major facilitator superfamily [IPR011701] 2 5 2.0404528096832184 0.0413052466334806 1.900485436893204 4.145631067961165 1.0239318262629833 0.2378354197978781 1.3191273068698348 1.552684909115802 1.329586452483978 0.2573287434106264 0.0050357755542779 0.1071891284628969 0.0211645746663273 0.0189056140649968 0.1078274882909933 +Proteasome, subunit alpha/beta [IPR001353] 4 14 2.011422637579916 0.0442808342176239 5.075242718446602 13.970873786407768 1.2284854682369022 0.3020132543529001 2.3027355385508845 0.1681602725795027 1.1101966392985694 0.3179790146746512 0.0225400063340814 1.0 1.0 0.000464221556229 0.000732082482726 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..239958034ad02780dca4e1bcfa9a75cf37eb2b17 --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 2395, + "title": "Average number of proteins per term", + "value": 1.2881002087682671 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2dace2ee6eb71da8dfeecd1553552615d9f43a2d --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a56c86fa9fc8e634f5603058d4c5ccf9f4e07861 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,108 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome B-type subunit [IPR023333] 0.7939255388634976 2.2195825890462726 0.0264471152385172 1.0 0.1426202617986162 7 P28070,P49720,Q99436,P28072,P49721,P28074 6 +Annexin [IPR001464] 0.8120931525833728 2.111824727324483 0.0347014855568634 1.0 0.1544796615403123 6 P08133,P09525,P20073 3 +Major facilitator superfamily [IPR011701] 0.833404968048849 2.0404528096832184 0.0413052466334806 1.0 0.1657919739137882 5 Q6NT16,P53985 2 +Aminopeptidase N-type [IPR034016] 0.902992129375616 2.0401822957390556 0.0413321724203092 1.0 0.1657919739137882 4 P55786 1 +Proteasome, subunit alpha/beta [IPR001353] 0.6025896892910949 2.011422637579916 0.0442808342176239 1.0 0.172055854132453 14 P28070,Q99436,P28072,P49721 4 +P-type ATPase [IPR001757] 0.811791978789639 1.95036390939213 0.0511327602837279 1.0 0.1832440521203761 5 P35670,Q9HD20 2 +Type 1 protein exporter [IPR039421] 0.875996764092906 1.933685297549038 0.0531518326071258 1.0 0.1863262812748473 4 Q03519,P08183 2 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.7530118380804741 1.853894571404372 0.0637542447133148 1.0 0.206629345926706 6 Q9UIQ6,P55786 2 +Beta tubulin [IPR002453] 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.2231981718841356 5 Q9BVA1,P68371,P07437 3 +Tubulin [IPR000217] 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.2231981718841356 5 Q9BVA1,P68371,P07437 3 +Eukaryotic porin/Tom40 [IPR027246] 0.8211602866277437 1.7142706933709595 0.0864790228636307 1.0 0.2450004138598437 4 P45880 1 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9915226605803724 1.6728425650436782 0.0943582929705399 1.0 0.2577893179801249 2 Q99595 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.9872839908705588 1.6560955955971417 0.0977024611601868 1.0 0.2630954781637244 2 Q5VW38 1 +Mini-chromosome maintenance protein [IPR031327] 0.7086236592656661 1.6557731326971512 0.0977677706555146 1.0 0.2630954781637244 6 P33991 1 +CD36 family [IPR002159] 0.9869579393544192 1.6548070438131257 0.0979636447189671 1.0 0.2630954781637244 2 Q8WTV0 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9866318878382796 1.653518447224102 0.0982253949056106 1.0 0.2630954781637244 2 Q93050 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9866318878382796 1.653518447224102 0.0982253949056106 1.0 0.2630954781637244 2 Q93050 1 +Haem oxygenase-like [IPR016053] 0.9863058363221396 1.6522298061110303 0.0984877124756924 1.0 0.2630954781637244 2 P30519 1 +Haem oxygenase [IPR002051] 0.9863058363221396 1.6522298061110303 0.0984877124756924 1.0 0.2630954781637244 2 P30519 1 +Ribosomal protein S6 kinase II [IPR016239] 0.973915878708837 1.6032313043097166 0.1088835965673296 1.0 0.2782613393723345 2 Q15418 1 +Palmitoyl protein thioesterase [IPR002472] 0.9644603847407912 1.5658048522042856 0.1173943099510492 1.0 0.2913568625209979 2 P50897 1 +Cytochrome P450 [IPR001128] 0.95891750896642 1.5438554822563966 0.1226233468496142 1.0 0.2988819820993946 2 Q16850 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.9611872146118696 1.5306232943330338 0.1258625211882922 1.0 0.3031821366998876 3 Q9H3G5,Q9HB40 2 +Nucleobindin [IPR040250] 0.950440169546792 1.510276557388777 0.130972870896016 1.0 0.3105742829662954 2 P80303 1 +Mpv17/PMP22 [IPR007248] 0.9546640574037796 1.5066699462248507 0.1318952787075531 1.0 0.3118353331733364 3 Q567V2,Q9NR77 2 +Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019] 0.7050424057203907 1.4944450691234148 0.135059329195406 1.0 0.315885833420896 5 Q14344,P09471 2 +Histidine phosphatase superfamily, clade-2 [IPR000560] 0.9276165634170273 1.4198634674409558 0.1556474333927198 1.0 0.3438685514063458 2 Q9NPH0 1 +Nucleosome assembly protein (NAP) [IPR002164] 0.9292237442922372 1.41315627709051 0.1576097791301038 1.0 0.3460044066456305 3 P55209,Q01105 2 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.9207436399217186 1.3819685948573497 0.1669813441805936 1.0 0.3579108102482919 3 Q99436,P28072 2 +Calcium uptake protein 1/2/3 [IPR039800] 0.911966090642325 1.3579155965355 0.1744904678275269 1.0 0.3678328083020383 2 Q9BPX6 1 +Acyl-CoA oxidase [IPR012258] 0.9021845451581432 1.3192455163551975 0.1870870459772768 1.0 0.3816639481393339 2 O15254 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.9021845451581432 1.3192455163551975 0.1870870459772768 1.0 0.3816639481393339 2 O15254 1 +Porin, eukaryotic type [IPR001925] 0.8820611536793488 1.2398299807553832 0.2150382865718714 1.0 0.415671264196636 3 P45880 1 +TAF15/EWS/TLS family [IPR034870] 0.8770384866275198 1.2214123306254907 0.2219299408491579 1.0 0.4236860491368932 3 Q92804,P35637 2 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.8734507501630722 1.2082650422204888 0.2269453303707784 1.0 0.429671198607126 3 Q9ULX6,O43823 2 +HnRNP-L/PTB [IPR006536] 0.6965692515191306 1.2049846085977929 0.2282092437102709 1.0 0.430243465588648 4 Q8WVV9 1 +KH domain-containing BBP-like [IPR045071] 0.6881328392599109 1.1703213577684208 0.2418716700830754 1.0 0.4469773532785228 4 Q96PU8,O75525 2 +Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699] 0.8627323117052486 1.1639779504698022 0.2444329475640301 1.0 0.4495649567205165 2 Q9NQT5 1 +HnRNP R/Q splicing factor [IPR006535] 0.8480599934789671 1.1066753803706304 0.2684343034040373 1.0 0.4778829157978681 2 O60506 1 +Oligosaccharyl transferase, STT3 subunit [IPR003674] 0.8461036843821458 1.0990593680259215 0.2717421713805215 1.0 0.4808589808036516 2 P46977 1 +Nucleoside diphosphate kinase [IPR001564] 0.8444734268014319 1.0927174670427136 0.2745178682378497 1.0 0.4830788349960691 2 P22392 1 +Disks large 1-like [IPR016313] 0.8382784479947795 1.0686597051530065 0.2852230346771489 1.0 0.4953656040984567 2 Q92796 1 +Prolyl 4-hydroxylase [IPR045054] 0.8320834691881305 1.0446719379083094 0.2961746187958791 1.0 0.5066701514400933 2 O15460 1 +Tropomyosin [IPR000533] 0.8288229540267347 1.0320769170289728 0.3020360863382763 1.0 0.5106431805558966 2 P06753 1 +Tropomodulin [IPR004934] 0.8196935115748287 0.9969304669755914 0.3187982619751834 1.0 0.5229601626236742 2 Q9NYL9 1 +Ancient conserved domain protein family [IPR045095] 0.8187153570264178 0.9931758208502024 0.3206242793581406 1.0 0.5236419071149404 2 Q6P4Q7 1 +Nonaspanin (TM9SF) [IPR004240] 0.8112723287854617 0.9823320766649593 0.325936276835882 1.0 0.5274441777175253 3 Q9HD45 1 +Importin beta family [IPR040122] 0.6402293612876336 0.974499247729493 0.3298087124756734 1.0 0.5294181410048512 4 Q92973,Q8TEX9 2 +Glycoside hydrolase, family 29 [IPR000933] 0.8079556569938224 0.9520280386540244 0.3410827621946355 1.0 0.5402732906456033 2 Q9BTY2 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.8079556569938224 0.9520280386540244 0.3410827621946355 1.0 0.5402732906456033 2 Q9BTY2 1 +Zinc transporter Msc2-like [IPR045316] 0.8069775024454031 0.948301971136246 0.3429757477006947 1.0 0.5414811573784863 2 Q8TAD4 1 +Cation efflux protein [IPR002524] 0.8069775024454031 0.948301971136246 0.3429757477006947 1.0 0.5414811573784863 2 Q8TAD4 1 +E3 ubiquitin ligase Bre1 [IPR013956] 0.7988262145419025 0.9173536386733314 0.358957358364127 1.0 0.5568023790687074 2 O75150 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.7883925660254293 0.878025850821432 0.3799296901241278 1.0 0.5774119129766755 2 O96005 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.7883925660254293 0.878025850821432 0.3799296901241278 1.0 0.5774119129766755 2 O96005 1 +Membrane bound O-acyl transferase, MBOAT [IPR004299] 0.7861102054124682 0.8694689616297747 0.3845906777967649 1.0 0.5791652021068586 2 Q96N66 1 +Beta-hexosaminidase [IPR025705] 0.7851320508640566 0.8658070270330431 0.3865959949927564 1.0 0.5808641204564942 2 P06865 1 +Proteasome activator PA28 [IPR009077] 0.7733202870189047 0.8474965493267086 0.3967184096151508 1.0 0.5893651190556387 3 Q06323,Q9UL46 2 +Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311] 0.7786110205412624 0.8414781743972134 0.4000801070652633 1.0 0.5920785479249054 2 Q9UKU0 1 +Isocitrate dehydrogenase NADP-dependent [IPR004790] 0.7717639387023283 0.816097835310803 0.4144441819161351 1.0 0.6010234551211356 2 P48735 1 +Importin subunit alpha [IPR024931] 0.5491297275669855 0.8156211684996201 0.4147168384863049 1.0 0.6010234551211356 5 P52292 1 +THRAP3/BCLAF1 family [IPR029199] 0.7678513205086388 0.8016749943420655 0.4227409841144571 1.0 0.6084523178810847 2 Q9NYF8 1 +Prefoldin beta-like [IPR002777] 0.7492066481460126 0.7637764995842864 0.4450004436023549 1.0 0.6276894530317028 3 Q9UHV9 1 +Arfaptin family [IPR030798] 0.7469840234757107 0.7258409143400318 0.4679363016421383 1.0 0.6438555282476944 2 P53367 1 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.7404629931529176 0.7025551793316298 0.482333002817592 1.0 0.6545785151996851 2 P31689 1 +Sister chromatid cohesion protein Pds5 [IPR039776] 0.728399087055755 0.6600553046458567 0.5092183394723317 1.0 0.6741724284335183 2 Q29RF7 1 +TB2/DP1/HVA22-related protein [IPR004345] 0.7277469840234772 0.657780565139154 0.51067914446147 1.0 0.675359774149763 2 Q00765 1 +Peptidase, FtsH [IPR005936] 0.7228562112813832 0.640797254291496 0.5216544170811588 1.0 0.6830849255928788 2 Q9Y4W6 1 +Rho-associated protein kinase 1/2 [IPR020684] 0.7101402021519345 0.5973093877389558 0.5503008379241905 1.0 0.7020967680011628 2 Q13464 1 +RNA-binding protein 26/27 [IPR045137] 0.701988914248447 0.569974375401759 0.5686950780681315 1.0 0.7134754908188449 2 Q9P2N5 1 +CPSF6/7 family [IPR034772] 0.6974241930225108 0.5548632773879241 0.5789881816523041 1.0 0.7218514810292912 2 Q8N684 1 +Cohesin subunit Scc3/SA [IPR039662] 0.6964460384740814 0.5516441332749562 0.581192192994139 1.0 0.7226328936926406 2 Q8WVM7 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.6944897293772421 0.5452262545583769 0.5855979165841418 1.0 0.7251845968040433 2 Q5T9A4 1 +Ras-like guanine nucleotide exchange factor [IPR008937] 0.6938376263449796 0.5430930582063336 0.587065731932426 1.0 0.7252040668831821 2 Q8TEU7 1 +Syntaxin [IPR045242] 0.4392065157736413 0.5398673359574753 0.5892885256083218 1.0 0.725691700852831 7 Q86Y82 1 +Tight junction protein ZO [IPR005417] 0.6902510596674274 0.531415729359349 0.5951307239392394 1.0 0.7277995916589158 2 Q9UDY2 1 +JmjC domain-containing [IPR039994] 0.6775350505379831 0.4907963747098111 0.623570474384487 1.0 0.7436306124654323 2 Q8IUF8 1 +Isocitrate dehydrogenase NAD-dependent [IPR004434] 0.6732963808281687 0.4775398114730764 0.632977778665881 1.0 0.747398134140488 2 P50213 1 +Protein kinase C, alpha/beta/gamma types [IPR014375] 0.6726442777958896 0.4755133709580067 0.6344211051849893 1.0 0.7478379844255488 2 P05771 1 +14-3-3 protein [IPR000308] 0.4436826640548437 0.4661902708445656 0.641079312747538 1.0 0.7535849223074423 6 P63104,P31946,P61981,P27348,P62258 5 +U3 snoRNP protein/Ribosome production factor 1 [IPR044281] 0.6690577111183542 0.4644311221916141 0.6423388967331425 1.0 0.7541184596450374 2 Q9H9Y2 1 +Sorting nexin-5/6/32 [IPR014637] 0.6022171503097469 0.2801296741021012 0.7793780190918069 1.0 0.8232095503282555 2 Q9Y5X3 1 +Protein arginine N-methyltransferase [IPR025799] 0.4486133768352253 0.2800367723182782 0.7794492928483141 1.0 0.8232095503282555 4 Q86X55,O60678,Q99873 3 +CTP synthase [IPR004468] 0.5862406260189064 0.2431586177918498 0.8078825230931712 1.0 0.8416175044837516 2 Q9NRF8 1 +Transmembrane emp24 domain-containing protein [IPR015720] 0.3870757180156662 0.2125558019236771 0.8316734485400743 1.0 0.8622761511919819 5 Q7Z7H5,P49755,Q9Y3B3,Q9BVK6 4 +Glutathione Transferase family [IPR040079] 0.3240288591443819 0.188453931663519 0.8505208256207086 1.0 0.8791529466385831 11 Q5HYI7,Q13505 2 +Stomatin/HflK/HflC family [IPR001972] 0.5526573198565281 0.1754192922978075 0.8607501825575306 1.0 0.8881933163400627 2 Q9UJZ1 1 +Flotillin family [IPR027705] 0.5337463319204331 0.1433899354860045 0.8859822311577548 1.0 0.9099174286547268 2 Q14254 1 +Lysosome-associated membrane glycoprotein [IPR002000] 0.5330942288881558 0.1423643227584059 0.8867922416195688 1.0 0.9103589449973714 2 P11279 1 +HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380] 0.3784665579118973 0.1144562270165812 0.908876144079794 1.0 0.9290475309735836 4 Q86UY8,P49902,Q9H857 3 +Prefoldin alpha-like [IPR004127] 0.4760563224818721 0.0824145757816872 0.9343170456819024 1.0 0.9497832446554144 3 Q9UBK9 1 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.484512552983358 0.0802643555141828 0.9360270068961732 1.0 0.9511178114197432 2 Q13310 1 +Protein disulphide isomerase [IPR005792] 0.4598825831702469 0.0649745625917846 0.9481942535579876 1.0 0.9626643651002036 3 P07237,P13667 2 +Calponin/LIMCH1 [IPR001997] 0.4646234104988442 0.0624482442515278 0.950205876544981 1.0 0.9642979128496736 2 Q15417 1 +Vacuolar protein sorting-associated protein 33 [IPR027121] 0.4385392892076899 0.0448353875937667 0.9642385182223804 1.0 0.9764698736332352 2 Q9H267 1 +Tricarboxylate/iron carrier [IPR004686] 0.4298760600130357 0.0394568712888399 0.9685261384452484 1.0 0.9799831438852428 3 Q96NB2,Q6P4A7 2 +Paraneoplastic encephalomyelitis antigen [IPR002343] 0.4222367134007137 0.0366869692084724 0.970734598714809 1.0 0.9818029408454256 2 Q15717 1 +Chaperone DnaJ [IPR012724] 0.4182682310581953 0.0317576772818855 0.974665298233912 1.0 0.985362342452604 3 P31689 1 +Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238] 0.3987610042386705 0.0281206123324387 0.9775659543092908 1.0 0.9870115849891098 2 O60220 1 +Hexokinase [IPR001312] 0.3971307466579725 0.0276452511268541 0.9779450902626964 1.0 0.9870115849891098 2 P52789 1 +Erlin1/2 [IPR033294] 0.382458428431689 0.0239605525491276 0.9808840741714852 1.0 0.9891441505855608 2 O75477 1 +Cell-cycle alteration and expression-elevated protein in tumour [IPR032337] 0.3975864318329984 0.020669308651739 0.9835094519355384 1.0 0.9913742160713868 3 Q9NQG5,Q96P16 2 +Alanine-tRNA ligase, eukaryota/bacteria [IPR023033] 0.3469188131724842 0.0185328470810819 0.9852137738798232 1.0 0.9918398438176446 2 Q5JTZ9 1 +Alanine-tRNA ligase, class IIc [IPR002318] 0.3469188131724842 0.0185328470810819 0.9852137738798232 1.0 0.9918398438176446 2 Q5JTZ9 1 +Ribosome biogenesis protein Bms1/Tsr1 [IPR039761] 0.3025758069775029 0.0159252384898663 0.9872940351508804 1.0 0.9930992079741112 2 Q2NL82 1 +Prenylated rab acceptor PRA1 [IPR004895] 0.3496412263535488 0.0052904514213128 0.9957788501821394 1.0 0.9994957461900384 3 O60831,Q9UI14 2 +La domain containing protein [IPR045180] 0.2764360313316001 0.0011571781090334 0.999076705658761 1.0 1.0 5 Q6PKG0,Q4G0J3,Q71RC2,Q92615 4 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ebd44d3009f70e9d549e6c41bbfdff788f257582 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-oxoisovalerate dehydrogenase subunit alpha [IPR034616]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome non-ATPase regulatory subunit 9 [IPR035269]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S10, mitochondrial [IPR040055]", "28S ribosomal protein S17, mitochondrial [IPR039193]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3'5'-cyclic nucleotide phosphodiesterase [IPR023088]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-keto-steroid reductase [IPR042829]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease 1 [IPR016494]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-formyltetrahydrofolate cyclo-ligase [IPR002698]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "50S ribosomal protein uL4 [IPR013005]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 10 [IPR042951]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "ALG11 mannosyltransferase [IPR038013]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1 complex subunit sigma [IPR044733]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit A [IPR000568]", "ATP synthase, F0 complex, subunit A, bacterial/mitochondria [IPR045083]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-binding cassette sub-family C member 4 [IPR030240]", "ATP-binding cassette subfamily B member 10-like [IPR030260]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Abr/Bcr [IPR037769]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 2/3 complex subunit 5 [IPR006789]", "Actin-related protein 3 [IPR015623]", "Activating signal cointegrator 1 complex subunit 1 [IPR009210]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-CoA-binding domain-containing protein 5 [IPR016347]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenomatous polyposis coli (APC) family [IPR026818]", "Adenomatous polyposis coli [IPR026836]", "Adenosine deaminase [IPR028893]", "Adenosine kinase [IPR001805]", "Adenosine/adenine deaminase [IPR006330]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Aldose 1-/Glucose-6-phosphate 1-epimerase [IPR008183]", "Aldose 1-epimerase [IPR015443]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 2 [IPR044554]", "Anaphase-promoting complex subunit 4 [IPR024789]", "Anaphase-promoting complex subunit 4, metazoa [IPR017169]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 2 [IPR005293]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat protein deleted in velo-cardio-facial syndrome [IPR028444]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase B [IPR028772]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 9 [IPR007241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCAS3-like [IPR045142]", "BCP1 family [IPR025602]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "BRO1 domain-containing protein BROX [IPR038898]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Band-7 stomatin-like [IPR043202]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-2-syntrophin [IPR028550]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [IPR013109]", "Bifunctional polynucleotide phosphatase/kinase PNKP [IPR006550]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biorientation of chromosomes in cell division protein 1-like 1 [IPR043244]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 2-like [IPR039934]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD166 antigen [IPR039810]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD34/Podocalyxin [IPR013836]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDC50/LEM3 family [IPR005045]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CGG triplet repeat-binding protein 1 [IPR033375]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation efflux protein [IPR002524]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle control protein 50A [IPR030351]", "Cell cycle regulator Mat89Bb [IPR019355]", "Cell division cycle protein 123 [IPR009772]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centromere protein Cenp-F [IPR043513]", "Centromere protein I [IPR012485]", "Centromere protein P [IPR027801]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Charged multivesicular body protein 1a [IPR029888]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin modification-related protein Eaf7/MRGBP [IPR012423]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromodomain-helicase-DNA-binding protein 8 [IPR034724]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 127 [IPR034607]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 137 [IPR026680]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 43 [IPR037666]", "Coiled-coil domain-containing protein 51 [IPR037660]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 90-like [IPR024461]", "Coiled-coil domain-containing protein 93 [IPR039116]", "Coilin [IPR024822]", "Complex I intermediate-associated protein 30, mitochondrial [IPR039131]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 6 [IPR010490]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Core-binding factor, beta subunit [IPR003417]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin 7 [IPR027331]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cys/Met metabolism, pyridoxal phosphate-dependent enzyme [IPR000277]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "D-glucuronyl C5-epimerase [IPR039721]", "DAD/Ost2 [IPR003038]", "DDB1- and CUL4-associated factor 16 [IPR028216]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase alpha, subunit B [IPR016722]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA polymerase epsilon, subunit B [IPR016266]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad4 [IPR004583]", "DNA repair protein Rad4, subgroup [IPR018026]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication ATP-dependent helicase/nuclease Dna2 [IPR026851]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "DUF5568 family [IPR040419]", "Daxx protein [IPR005012]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Dehydrogenase/reductase SDR member 4-like [IPR029511]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Disks large 1-like [IPR016313]", "Divalent ion tolerance protein, CutA [IPR004323]", "Divergent protein kinase domain 2A/B [IPR020519]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dpy-19/Dpy-19-like [IPR018732]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1 [IPR027741]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dysbindin [IPR007531]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 SUMO-protein ligase PIAS2 [IPR027228]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase RNF213 [IPR031248]", "E3 ubiquitin-protein ligase ZNF598/Hel2 [IPR044288]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ER membrane protein complex subunit 8/9 [IPR005366]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "ESCRT-II complex, Vps25 subunit [IPR008570]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Endonuclease III-like protein 1 [IPR030841]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelial protein C receptor [IPR015669]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ephrin [IPR031328]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Erbin [IPR032927]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Essential MCU regulator, mitochondrial [IPR018782]", "Esterase-like [IPR000801]", "Etoposide-induced 2.4 [IPR009890]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Exo84 [IPR033961]", "Exocyst complex component Sec8/EXOC4 [IPR039682]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM105 [IPR023235]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM177 family [IPR028260]", "FAM3 family [IPR039220]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Far11/STRP [IPR040185]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 2 [IPR030305]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fyv7/TAP26 [IPR013730]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein alpha subunit, group Q [IPR000654]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI transamidase subunit PIG-U [IPR009600]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP cyclohydrolase 1 type 2/Nif3 [IPR002678]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "Galactokinase [IPR000705]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gem-associated protein 4 [IPR033265]", "Geranylgeranyl transferase type-1 subunit beta [IPR041960]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glucocorticoid receptor [IPR001409]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose transporter GLUT [IPR045263]", "Glucose transporter, type 1 (GLUT1) [IPR002439]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycosyltransferase 61 [IPR007657]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgi-associated PDZ and coiled-coil motif-containing protein [IPR038879]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "Guided entry of tail-anchored proteins factor CAMLG [IPR016719]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 1 [IPR026243]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS augmin-like complex subunit 6 [IPR026797]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HIRA-interacting protein 3 [IPR037647]", "HMG-CoA lyase [IPR043594]", "HS1-associating protein X-1 [IPR017248]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 12A [IPR026685]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H3/CENP-A [IPR000164]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex subunit SAP30/SAP30-like [IPR024145]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone transcription regulator 3/CABIN1 [IPR033053]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase SETD1A [IPR037841]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Set1-like [IPR044570]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Huntingtin-interacting protein 1 [IPR030554]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxyacylglutathione hydrolase [IPR017782]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Innexin [IPR000990]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integral membrane protein SYS1 [IPR016973]", "Integral membrane protein SYS1-related [IPR019185]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 12 [IPR039053]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intron Large complex component GCFC2-like [IPR012890]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isochorismatase domain-containing protein 2 [IPR040318]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "Junctional adhesion molecule C [IPR042974]", "K/Cl co-transporter 4 [IPR030354]", "K/Cl co-transporter [IPR000076]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore Mis14/Nsl1 [IPR013950]", "Kinetochore protein Ndc80 [IPR005550]", "Kinetochore protein Spc25 [IPR045143]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-rich repeat-containing 41 [IPR026137]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Lipoma-preferred partner [IPR028771]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "LysM and putative peptidoglycan-binding domain-containing protein 1-4 [IPR045030]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "M-phase phosphoprotein 6 [IPR019324]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICAL3 [IPR029941]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Magnesium transporter protein 1 [IPR006844]", "Major centromere autoantigen B [IPR033062]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Matrix-remodeling-associated protein 7 [IPR026622]", "Mediator complex, subunit Med14 [IPR013947]", "Mediator complex, subunit Med24, [IPR021429]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionine-tRNA synthetase, type 2 [IPR023457]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylmalonic aciduria and homocystinuria type D protein [IPR019362]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "Mff/Tango-11 [IPR008518]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microfibrillar-associated protein 1 [IPR033194]", "Microtubule associated protein 1 [IPR026074]", "Microtubule associated protein 1A [IPR015656]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein 7 family [IPR008604]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial calcium uniporter regulator 1 [IPR012439]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial dynamics protein MID49/MID51 [IPR045909]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit TIM22 [IPR039175]", "Mitochondrial import inner membrane translocase subunit Tim10 [IPR027100]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit TOM6 homologue [IPR029182]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial intermembrane space import and assembly protein 40 [IPR039289]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial outer membrane transport complex protein, metaxin [IPR017410]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitoguardin [IPR019392]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mortality factor 4-like protein 2 [IPR038012]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multifunctional methyltransferase subunit Trm112 [IPR039127]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [IPR033202]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-plastoquinone oxidoreductase, chain 5 subgroup [IPR018393]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-quinone oxidoreductase, chain 5-like [IPR003945]", "NADH-quinone oxidoreductase, chain I [IPR010226]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NF-kappa-B/Dorsal [IPR000451]", "NIF3-like protein 1, animal [IPR017222]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "NURS complex subunit red1 [IPR039278]", "Nck-associated protein 1 [IPR019137]", "Nectin-2 [IPR033318]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neutral amino acid SLC6 transporter [IPR002438]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nicotinate-nucleotide pyrophosphorylase [IPR004393]", "Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD [IPR027277]", "Nitric oxide synthase-interacting protein [IPR016818]", "Non-structural maintenance of chromosomes element 1 [IPR011513]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Not2/Not3/Not5 [IPR040168]", "Nuclear MIS12/MIND complex subunit PMF1/Nnf1 [IPR007128]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor NF-kappa-B, p100 subunit [IPR030497]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear hormone receptor [IPR001723]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear pore protein POM121 [IPR026090]", "Nuclear protein DGCR14/ESS-2 [IPR019148]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "Nurim-like [IPR033580]", "OCIA domain-containing protein 1/2 [IPR040187]", "Occludin [IPR002958]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Optineurin [IPR032939]", "Origin recognition complex, subunit 3 [IPR020795]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IB [IPR027256]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PP2B [IPR043360]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pannexin [IPR039099]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 [IPR012462]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 1 [IPR002467]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Periphilin-1 [IPR028851]", "Peroxin-3 [IPR006966]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisome membrane protein, Pex16 [IPR013919]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatase Gpp1/Gpp2-like [IPR045228]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylase kinase alpha/beta subunit [IPR008734]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Podocalyxin [IPR017403]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyadenylate-binding protein-interacting protein 2-like [IPR040396]", "Polycomb protein EED [IPR037352]", "Polynucleotide kinase 3 phosphatase [IPR013954]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prefoldin, subunit 4 [IPR016661]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable C-mannosyltransferase DPY19L3 [IPR030039]", "Probable methyltransferase TARBP1 [IPR025806]", "Probable methyltransferase Trm3/TARBP1 [IPR045330]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Prostate apoptosis response 4 [IPR026117]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome inhibitor PI31-like [IPR045128]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM3C [IPR039219]", "Protein FAM8A1 [IPR039871]", "Protein FRG1 [IPR010414]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LCHN/Anr2 [IPR018626]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein Mon2-like [IPR026829]", "Protein NDRG3 [IPR030692]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SON [IPR032922]", "Protein Sec13 [IPR037596]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein XRP2 [IPR039093]", "Protein Yip1/4-like [IPR045231]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein jagunal [IPR009787]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C, alpha/beta/gamma types [IPR014375]", "Protein kinase C, delta [IPR027436]", "Protein kinase C, delta/epsilon/eta/theta types [IPR014376]", "Protein kinase C-binding protein 1 [IPR021931]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF1387 [IPR009816]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF4615 [IPR029274]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase 4 core regulatory subunit R2 [IPR015267]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein spinster-like [IPR044770]", "Protein strawberry notch [IPR026741]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative peptidyl-tRNA hydrolase PTRHD1 [IPR042237]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate homeostasis protein [IPR011078]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "RAD3/XPD family [IPR001945]", "RFT1 [IPR007594]", "RFX-like DNA-binding protein [IPR039779]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 1 [IPR017770]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein 6 [IPR028806]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "ROK family [IPR000600]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab protein geranylgeranyltransferase component A [IPR001738]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab4 [IPR041819]", "Rab9 [IPR041824]", "Rad21/Rec8-like protein [IPR039781]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Ran-interacting Mog1 protein [IPR007681]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein [IPR039360]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Ras-related protein Rap2 [IPR041840]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Regulatory associated protein of TOR [IPR004083]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulon-4-interacting protein 1 [IPR037397]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma protein family [IPR028309]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein 7 [IPR040446]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, bacterial-type [IPR005823]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L16 [IPR000114]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27/L41, mitochondrial [IPR019189]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L55, mitochondrial [IPR018615]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein Rsm22-like [IPR015324]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S16 [IPR000307]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S18 [IPR001648]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S27/S33, mitochondrial [IPR013219]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome recycling factor [IPR002661]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "Rieske iron-sulphur protein [IPR014349]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3 and PX domain-containing protein 2B [IPR030512]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNARE associated Golgi protein [IPR032816]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SSNA1 family [IPR033362]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BAF60B [IPR030090]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1 [IPR027109]", "SWR1-complex protein 5/Craniofacial development protein 1/2 [IPR027124]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sarcolemmal membrane-associated protein [IPR030498]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Schlafen family [IPR029684]", "Sds3-like [IPR013907]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "Sec20 [IPR005606]", "SecY/SEC61-alpha family [IPR002208]", "Sedoheptulokinase [IPR042027]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 6 [IPR030644]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase TOUSLED-like 2 [IPR027086]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sla2 family [IPR030224]", "Slowmo/Ups family [IPR037365]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snapin [IPR017246]", "Snapin/Pallidin/Snn1 [IPR028119]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium/solute symporter [IPR001734]", "Sodium:dicarboxylate symporter [IPR001991]", "Sodium:neurotransmitter symporter [IPR000175]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-4 [IPR034783]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingolipid delta(4)-desaturase DES1 [IPR031196]", "Sphingolipid delta4-desaturase [IPR011388]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Stomatin [IPR028515]", "Stomatin/HflK/HflC family [IPR001972]", "Stromal interaction molecule 1 [IPR030463]", "Stromal interaction molecule [IPR037608]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar/inositol transporter [IPR003663]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syndetin [IPR040047]", "Syntaxin [IPR045242]", "Syntaxin-17 [IPR028676]", "Syntaxin-3 [IPR031186]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "Syntrophin [IPR015482]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex subunit 7/Mft1 [IPR008501]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM70 family [IPR009724]", "TMEM70/TMEM186/TMEM223 protein family [IPR045325]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TPX2 [IPR009675]", "TREX component Tex1/THOC3 [IPR040132]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Telomeric repeat-binding factor 1/2 [IPR017357]", "Telomeric repeat-binding factor 2 [IPR030657]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 21A/21B [IPR040364]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation factor, mitochondrial [IPR039150]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor II-I [IPR016659]", "Transcription factor IIA, alpha/beta subunit [IPR004855]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription initiation factor TFIIE, beta subunit [IPR016656]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transforming growth factor-beta-related [IPR015615]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation initiation factor aIF-2, bacterial-like [IPR000178]", "Translation machinery-associated protein 16 [IPR021346]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 161A/B [IPR019395]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 41A/B [IPR045014]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Trm112-like [IPR005651]", "Tropomodulin [IPR004934]", "Tropomodulin-1 [IPR030135]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tryptophan-tRNA ligase, bacterial-type [IPR024109]", "TspO/MBR-related protein [IPR004307]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Type-1 angiotensin II receptor-associated protein [IPR009436]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing [IPR020004]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronosyl/UDP-glucosyltransferase [IPR002213]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0767 family [IPR031933]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "UbiE/COQ5 methyltransferase [IPR004033]", "Ubiquinol-cytochrome-c reductase complex assembly factor 2 [IPR037698]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin thioesterase otulin [IPR023237]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-like modifier-activating enzyme Atg7 [IPR006285]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Ubiquitously expressed transcript protein UXT [IPR003994]", "Uncharacterised protein family UPF0449 [IPR028227]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Ureohydrolase [IPR006035]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein sorting-associated protein Vta1-like [IPR044538]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Vezatin [IPR026858]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "Vps52 [IPR007258]", "Vps72/YL1 family [IPR008895]", "WASH complex subunit 7 [IPR027307]", "WASH complex, subunit strumpellin [IPR019393]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat and coiled-coil-containing protein family [IPR028041]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "ZPR1 family [IPR040141]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 [IPR044598]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger protein 277 [IPR040048]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 622/Rei1/Reh1 [IPR040025]", "Zinc finger protein 638 [IPR033096]", "Zinc transporter Msc2-like [IPR045316]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "siRNA-mediated silencing protein NRDE-2 [IPR013633]", "tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 [IPR014816]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase, Trm7 [IPR028590]", "tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote [IPR025763]", "tRNA (guanine-N-7) methyltransferase, Trmb type [IPR003358]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGL", "AGPS", "AGTRAP", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "API5", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAIAP2", "BANF1", "BASP1", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUD31", "BYSL", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C3orf58", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CAD", "CALD1", "CALR", "CALU", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CAST", "CBFB", "CBR1", "CBR4", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK5RAP3", "CDKAL1", "CDS2", "CDV3", "CEBPZ", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1L", "CHD8", "CHERP", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CIAPIN1", "CIP2A", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG6", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX54", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX29", "DIABLO", "DIAPH1", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPM1", "DPP3", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EED", "EEF1A2", "EEF1E1", "EEF1G", "EFNB1", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "F11R", "FADS2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GCAT", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMFB", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HCCS", "HCFC1", "HDAC2", "HDHD2", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IRGQ", "IRS4", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMF2", "LNPEP", "LONP1", "LPP", "LRPAP1", "LRPPRC", "LRRC41", "LRRC47", "LSM12", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MIPEP", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTR", "MTX1", "MTX2", "MTX3", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "NAA10", "NAA15", "NAA35", "NAA40", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCLN", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF1", "NDUFAF3", "NDUFB10", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NELFCD", "NELFE", "NES", "NF1", "NFKB2", "NHP2", "NIF3L1", "NIP7", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRDE2", "NRM", "NSA2", "NSF", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAIP2", "PAK2", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PAWR", "PBDC1", "PBRM1", "PC", "PCBD1", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM5", "RBM6", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX1", "RIOX2", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTFDC1", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARS", "SARS2", "SART1", "SBDS", "SBNO1", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A21", "SLC25A24", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLK", "SLMAP", "SLTM", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", 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b/interpro_homologous_superfamily/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ad2055249cce177fb653dcca1670bae40a009fa8ea20d9272e66d4d82b662a91 +size 152135 diff --git a/interpro_homologous_superfamily/basic/plot_9.png b/interpro_homologous_superfamily/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..f9019cb81655a59b79a9bb8bb0dc6ceb414d781b --- /dev/null +++ b/interpro_homologous_superfamily/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e84e9cb930411ac597c4679506835d6450ac9497a9cc5e65a5d96c88555e1d05 +size 149933 diff --git a/interpro_homologous_superfamily/consensus.joblib b/interpro_homologous_superfamily/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..be2c02baa6b4115678d2a499419a5624ea201229 --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c95f04ad01a1307cdd209444ce239c9f7bde608953c21f53899a85fa55732de3 +size 138500 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8f729b644081a12695b2be0d606b4408a4a9b67a --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,12 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +MFS transporter superfamily [IPR036259] 5 11 2.5929362584708304 0.0095160405634049 3.6432038834951457 8.356796116504855 0.9436301622284156 0.2543148229816532 1.924895010927015 2.2984539817025564 1.2198539986610124 0.2448337840515702 0.0052996216004284 0.2031027035797352 0.0103010078837345 0.0009339244808483 0.0274248441305744 +Zinc finger, RanBP2-type superfamily [IPR036443] 3 8 2.4078012130852677 0.0160489169963775 3.2742718446601944 8.616504854368932 0.6239078002715212 0.4100405386528319 1.463145369641179 0.7330740021954685 1.0299872364022182 0.3121093098016552 0.2676873295985275 1.0 1.0 0.0889449047367856 0.0168879338153791 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 3 6 2.3394416360877552 0.0193125888198713 2.3689320388349513 6.349514563106796 0.6640264147492347 0.3307390797434538 1.7803691733569 2.1393617497725477 1.1694677427725269 0.279101120079799 0.0199123159742315 1.0 0.1323778037089543 0.0003547957514141 0.0048470794580564 +Glycoside hydrolase superfamily [IPR017853] 10 15 2.277329717372888 0.022766543617847 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 0.0005228601887007 1.0 1.0 0.0003283361224853 2.0668745439053444e-05 +Six-bladed beta-propeller, TolB-like [IPR011042] 1 5 2.274940620217888 0.0229094921717305 1.3446601941747574 5.393203883495145 0.4812306698455429 0.3983263887517446 1.462357994456035 1.8263849452238317 1.127948748997717 0.299664609287172 0.0480381407843038 1.0 0.2033176172301104 0.1116515128715098 0.3253640261497879 +FAD/NAD(P)-binding domain superfamily [IPR036188] 5 21 2.1979450270666727 0.0279530236510165 5.128640776699029 19.483009708737864 1.1388517428876976 0.3148047818604211 2.42568278788952 1.8971625900564304 0.9268276914308484 0.2996934003616133 0.0193759682694979 0.1683799151698467 0.0057841877037216 0.065867090511777 0.0104893431674361 +Annexin superfamily [IPR037104] 3 6 2.111824727324483 0.0347014855568634 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 1.0 1.0 0.0003260526470588 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 3 6 2.0699245136455207 0.0384594139474299 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0006228809854352 0.0550816697898294 0.0001673348473236 0.0025378182642571 0.0019736987849612 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 4 6 1.977267189149281 0.0480114363876489 3.7524271844660193 6.847087378640777 0.510735400099038 0.3891602594566672 2.000453572849188 1.1755668998633355 1.2190917823770269 0.3170422836523225 1.0 1.0 1.0 1.0 0.0615084186624239 +MHC class I-like antigen recognition-like superfamily [IPR037055] 3 5 1.9623191820198955 0.0497253353198345 1.6286407766990292 3.3519417475728157 0.7088257141352072 0.3792248400111384 0.978137271268229 0.8617667089672962 1.1217132539816763 0.2987888107271844 1.0 1.0 1.0 0.2877500137996227 0.0276005264132961 +MHC classes I/II-like antigen recognition protein [IPR011162] 3 5 1.9623191820198955 0.0497253353198345 1.6286407766990292 3.3519417475728157 0.7088257141352072 0.3792248400111384 0.978137271268229 0.8617667089672962 1.1217132539816763 0.2987888107271844 1.0 1.0 1.0 0.353617241696185 0.053660443290246 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..853d922b0b27e2b9d997f129b93c3c30fc0777f0 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 944, + "title": "Average number of proteins per term", + "value": 4.807203389830509 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..9ad1cadfff189698184e1f27f66d421e744bd1a8 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c93b3004500965125acdc2e517fd34e598e4a916 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,107 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +MFS transporter superfamily [IPR036259] 0.7738535786656315 2.5929362584708304 0.0095160405634049 0.9998797764187196 0.1991657810459684 11 Q9H2V7,P41440,Q6NT16,P53985,Q16625 5 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.8154463262523648 2.4078012130852673 0.0160489169963775 0.9999997671953644 0.1991657810459684 8 P98175,Q92804,P35637 3 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.8656257633459856 2.3394416360877552 0.0193125888198713 0.999999989886842 0.1991657810459684 6 O15439,Q03519,P08183 3 +Glycoside hydrolase superfamily [IPR017853] 0.6398453201948608 2.2773297173728877 0.022766543617847 0.99999999963824 0.2079476981741696 15 P08195,P54802,P16278,P06865,P06280,P10253,P04066,Q9BTY2,O60502,P04062 10 +Six-bladed beta-propeller, TolB-like [IPR011042] 0.8906306996271888 2.274940620217888 0.0229094921717305 0.999999999684902 0.2079476981741696 5 Q15165 1 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5755272151060502 2.1979450270666727 0.0279530236510165 0.9999999999976188 0.2268140555542709 21 O95831,Q9UHG3,Q96CU9,Q9H9P8,Q6NUM9 5 +Annexin superfamily [IPR037104] 0.8120931525833728 2.111824727324483 0.0347014855568634 0.9999999999999968 0.2378925802263724 6 P08133,P09525,P20073 3 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.8023863014909101 2.0699245136455207 0.0384594139474299 1.0 0.243757315683587 6 Q8WUJ1,O43169,Q9UMX5 3 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.781074735648192 1.977267189149281 0.0480114363876489 1.0 0.2666813575018739 6 Q9BVA1,P68371,Q13885,P07437 4 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.8146489134597705 1.9623191820198953 0.0497253353198345 1.0 0.2666813575018739 5 Q9UNN8,P10321,P55899 3 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.8146489134597705 1.9623191820198953 0.0497253353198345 1.0 0.2666813575018739 5 Q9UNN8,P10321,P55899 3 +P-type ATPase, A domain superfamily [IPR008250] 0.811791978789639 1.95036390939213 0.0511327602837279 1.0 0.2666813575018739 5 P35670,Q9HD20 2 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.811791978789639 1.95036390939213 0.0511327602837279 1.0 0.2666813575018739 5 P35670,Q9HD20 2 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.811791978789639 1.95036390939213 0.0511327602837279 1.0 0.2666813575018739 5 P35670,Q9HD20 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.7530118380804741 1.853894571404372 0.0637542447133148 1.0 0.2964878344416322 6 Q9UIQ6,P55786 2 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.7530118380804741 1.853894571404372 0.0637542447133148 1.0 0.2964878344416322 6 Q9UIQ6,P55786 2 +Tubulin, C-terminal [IPR023123] 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.3218375350094546 5 Q9BVA1,P68371,P07437 3 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.3218375350094546 5 Q9BVA1,P68371,P07437 3 +Tubulin/FtsZ, C-terminal [IPR008280] 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.3218375350094546 5 Q9BVA1,P68371,P07437 3 +Alpha/Beta hydrolase fold [IPR029058] 0.4867802959239942 1.7655539155339015 0.0774707173385198 1.0 0.3279477899890705 26 P07099,P42785,Q8NCC3,P50897,Q9UMR5,Q9H3G5,Q9HB40 7 +Immunoglobulin E-set [IPR014756] 0.5806955102018393 1.7618612707014842 0.0780927395777937 1.0 0.3279826412532553 13 O43924,A6NIH7 2 +Porin domain superfamily [IPR023614] 0.8211602866277437 1.7142706933709595 0.0864790228636307 1.0 0.3459160914545229 4 P45880 1 +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.9931529181610694 1.6792815501787255 0.0930971849672446 1.0 0.3661822608711622 2 O43924 1 +Haem oxygenase-like, multi-helical [IPR016084] 0.9863058363221396 1.6522298061110303 0.0984877124756924 1.0 0.3820344978136468 2 P30519 1 +Mitochondrial carrier domain superfamily [IPR023395] 0.5161081460542108 1.625385185086888 0.1040805106090614 1.0 0.3914422391034023 18 Q70HW3,Q9BQT8,O43772 3 +L27 domain superfamily [IPR036892] 0.7276365105867804 1.5922825848923488 0.1113212241826504 1.0 0.4088997495269339 5 Q14168,Q12959,O14936 3 +Cytochrome P450 superfamily [IPR036396] 0.95891750896642 1.5438554822563966 0.1226233468496142 1.0 0.4287275534297625 2 Q16850 1 +SH3-like domain superfamily [IPR036028] 0.4529233500466275 1.5327927594056112 0.1253269252248001 1.0 0.4315252365403938 33 Q00013,Q14185,Q9NZW5,Q92796,O14936,P46108,O00459,Q9UQB8,Q9UDY2,Q13813,Q12959,Q92783,Q5T2T1,Q07157,Q14168,Q14247,Q96PC5,Q8N5V2 18 +Cyclic nucleotide-binding-like [IPR018490] 0.7122685089501921 1.525799788495978 0.1270597334034542 1.0 0.4343556926767358 5 Q6P4Q7,Q8TEU7 2 +Rho GTPase activation protein [IPR008936] 0.5894939794628323 1.4992725377450096 0.1338029436942225 1.0 0.4362842817475424 10 Q14C86,O15031,O00459 3 +G protein alpha subunit, helical insertion [IPR011025] 0.7050424057203907 1.4944450691234148 0.135059329195406 1.0 0.4381306074242726 5 Q14344,P09471 2 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.3685244811270862 1.4849816715314517 0.1375486793794018 1.0 0.441652902497127 80 Q7Z4L5,P13674,A0AVF1,O75718,O15091,O15460,Q96BR5,Q9Y5A7,O75153,Q9NYH9,Q96DB5,Q9Y6X3,Q9H7Z3,Q9NSK0,Q96TC7,Q96EK5,Q32P28,Q92791,O00231,Q99747,Q96EY7,Q9UJX4,Q9UJX3,Q13217,Q5R3I4,Q6DKK2 26 +Histidine phosphatase superfamily [IPR029033] 0.6957148660308794 1.4538915795178415 0.145976367729858 1.0 0.4474080881070972 5 Q9NPH0 1 +EF-hand domain pair [IPR011992] 0.4200075556262859 1.4344385357045828 0.1514471573435596 1.0 0.4481696443019445 46 Q9UBV8,Q8NF37,Q9Y680,P60660,Q8N163,O43852,Q8IYU8,P41208,P80303,Q13813,O43707,Q02818,Q15293,Q9NWM8,Q14257,Q9BPX6 16 +NAP-like superfamily [IPR037231] 0.9292237442922372 1.41315627709051 0.1576097791301038 1.0 0.457814449875653 3 P55209,Q01105 2 +K Homology domain, type 1 superfamily [IPR036612] 0.440457407617433 1.3982582609533971 0.1620355269770763 1.0 0.4621194485388522 25 P51114,Q96I24,Q92945,Q96AE4,Q13868,P61978,Q96PU8,Q9Y2W6,Q9Y6M1,Q9NQT5,O75525 11 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 0.4040620218001267 1.3932896053579114 0.1635322326667909 1.0 0.4633430788559449 132 P52272,P52597,P62995,Q8WVV9,Q96PK6,O60506,P98175,P31943,Q9UHX1,P23588,Q13242,Q9BWF3,P35637,O14979,Q8NFH5,Q8WXF1,P98179,P51991,P55795,Q9UKA9,Q53F19,Q13151,P38159,O95104,P31942,Q99729,O43390,Q07955,P23246,P22626,Q15233,Q8IY67,Q14103,Q92804,Q16629,Q8N684,Q9Y6M1,Q14011,O75494,Q9P2N5,Q01844 41 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.4717177017009678 1.321910871240382 0.1861978319318868 1.0 0.4923550513829166 18 P28070,Q99436,P28072,P49721 4 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.5967093441352611 1.2931930499288693 0.1959442988266631 1.0 0.5067710084722464 7 P22695,Q5JRX3,O43847 3 +Mannose-6-phosphate receptor binding domain superfamily [IPR009011] 0.8953836394535422 1.2887379392083185 0.1974892080573425 1.0 0.5069362334456586 3 P20645 1 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.6477692108796023 1.244394750952743 0.2133543138342708 1.0 0.5328213551839991 5 P49366,Q13423 2 +RNA-binding domain superfamily [IPR035979] 0.389442870385903 1.2036658322106224 0.2287187634870668 1.0 0.5522007998255528 133 P84103,P52272,P52597,Q13243,P62995,Q8WVV9,Q96I25,Q96PK6,O60506,Q8WUA2,P98175,Q5T8P6,Q96EP5,P08621,P31943,Q9UHX1,P23588,Q12849,Q13242,Q9BWF3,P35637,Q9Y5S9,P43243,O14979,Q8NFH5,Q8WXF1,Q96E39,P98179,P51991,P55795,Q9UKA9,Q9BXP5,Q96T37,Q13151,P09651,P38159,O95104,P31942,Q99729,Q86U42,O43390,Q07955,P23246,P22626,Q15233,Q8IY67,Q14103,Q92804,Q16629,Q01085,Q8N684,P07910,Q14011,Q71RC2,Q9Y6M1,Q76FK4,O75494,Q9P2N5,Q01844,P18615 60 +Prefoldin [IPR009053] 0.5975368883819464 1.1481867463933606 0.2508914794297605 1.0 0.5748986583819122 6 O15212,Q9UHV9 2 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.8535649075742919 1.135556493323768 0.2561422258527477 1.0 0.5826464125421539 3 P54802 1 +LEM/LEM-like domain superfamily [IPR011015] 0.591225730094034 1.1191271485234142 0.263085899346851 1.0 0.5843602093727702 6 Q86XL3 1 +Ribokinase-like [IPR029056] 0.8473744897658079 1.11299167046649 0.2657120068888319 1.0 0.5869036432113747 3 P55263 1 +Aldehyde dehydrogenase, C-terminal [IPR016163] 0.5327288564677426 1.1012220073682566 0.2708000457848114 1.0 0.587006722063581 9 O94788 1 +Aldehyde/histidinol dehydrogenase [IPR016161] 0.5327288564677426 1.1012220073682566 0.2708000457848114 1.0 0.587006722063581 9 O94788 1 +Aldehyde dehydrogenase, N-terminal [IPR016162] 0.5327288564677426 1.1012220073682566 0.2708000457848114 1.0 0.587006722063581 9 O94788 1 +Lamin tail domain superfamily [IPR036415] 0.8326810176125174 1.0595995895039187 0.2893268004432439 1.0 0.6013076030791877 3 P02545,Q03252 2 +Nucleoside diphosphate kinase-like domain superfamily [IPR036850] 0.8258509318205085 1.0348737822300589 0.3007278600526062 1.0 0.6013076030791877 3 P22392 1 +HAD-like superfamily [IPR036412] 0.424952459120149 1.0336693211868029 0.3012907799326862 1.0 0.6013076030791877 19 P35670,Q969T7,Q86UY8,P16615,Q9HD20,Q3ZCQ8 6 +HAD superfamily [IPR023214] 0.424952459120149 1.0336693211868029 0.3012907799326862 1.0 0.6013076030791877 19 P35670,Q969T7,Q86UY8,P16615,Q9HD20,Q3ZCQ8 6 +Cupredoxin [IPR008972] 0.824910335833078 1.0169919216424783 0.3091572724254467 1.0 0.608009302436712 2 P00403 1 +PDZ superfamily [IPR036034] 0.388670661699894 0.9871274922238704 0.3235801417201915 1.0 0.6150984295339914 24 Q00013,P57105,Q9NZW5,Q92796,Q9Y4G8,O14936,Q96HC4,Q9UDY2,Q12959,Q8TEU7,Q5T2T1,Q14168 12 +Regulatory factor, effector binding domain superfamily [IPR011256] 0.8115422236713561 0.9657117329524618 0.3341884467973197 1.0 0.6234661932345253 2 Q9Y6I9 1 +Cation efflux transmembrane domain superfamily [IPR027469] 0.8069775024454031 0.948301971136246 0.3429757477006947 1.0 0.6339664516843957 2 Q8TAD4 1 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.7939354417997999 0.8988768697839119 0.368718249519093 1.0 0.6554991102561654 2 P35611 1 +ENTH/VHS [IPR008942] 0.4222327091409814 0.876621575714528 0.380692216187966 1.0 0.6667410984813357 14 O95104,Q92783,O00291,Q9UJY4,Q13492 5 +Proteasome activator superfamily [IPR036252] 0.7733202870189047 0.8474965493267086 0.3967184096151508 1.0 0.6747787003183826 3 Q06323,Q9UL46 2 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.7733202870189047 0.8474965493267086 0.3967184096151508 1.0 0.6747787003183826 3 Q06323,Q9UL46 2 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.7733202870189047 0.8474965493267086 0.3967184096151508 1.0 0.6747787003183826 3 Q06323,Q9UL46 2 +Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100] 0.4642130935396291 0.8203993745033209 0.4119884719453117 1.0 0.6859208421805543 10 P16219,O15254 2 +Acyl-CoA dehydrogenase-like, C-terminal [IPR036250] 0.4642130935396291 0.8203993745033209 0.4119884719453117 1.0 0.6859208421805543 10 P16219,O15254 2 +Importin-alpha, importin-beta-binding domain superfamily [IPR036975] 0.5491297275669855 0.8156211684996201 0.4147168384863049 1.0 0.6886223849945282 5 P52292 1 +NET domain superfamily [IPR038336] 0.7600260841212896 0.7730148432073972 0.43951359621067 1.0 0.7092321962784145 2 P25440 1 +Glycosyl hydrolase, all-beta [IPR013780] 0.4664985804867785 0.7082335995059654 0.4788002040607915 1.0 0.7397217818923647 8 Q9BTY2,P10253,P06280,P04066 4 +Zinc finger, CCHC-type superfamily [IPR036875] 0.5717723967952033 0.70250297022629 0.4823655500392316 1.0 0.7401297846232426 4 Q9NUD5 1 +Isoprenoid synthase domain superfamily [IPR008949] 0.731659602217172 0.6714645155214535 0.5019246574327951 1.0 0.7467421229224029 2 P37268 1 +Peptidase M41-like [IPR037219] 0.7228562112813832 0.640797254291496 0.5216544170811588 1.0 0.7622937611836129 2 Q9Y4W6 1 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 0.3423497212286441 0.6024564840701253 0.5468703211638692 1.0 0.7834230717783647 31 Q08J23,P21964,Q96FX7 3 +Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964] 0.6938376263449796 0.5430930582063336 0.587065731932426 1.0 0.8141485716097061 2 Q8TEU7 1 +Ras guanine nucleotide exchange factor domain superfamily [IPR023578] 0.6938376263449796 0.5430930582063336 0.587065731932426 1.0 0.8141485716097061 2 Q8TEU7 1 +SNARE [IPR010989] 0.4599911757393939 0.5330875514514032 0.5939729759098666 1.0 0.8184226092514381 6 Q86Y82 1 +Acyl-CoA N-acyltransferase [IPR016181] 0.4182447402525532 0.5184465713619406 0.6041467285748527 1.0 0.8229141706244073 9 O60502,Q86UY6 2 +Ricin B-like lectins [IPR035992] 0.656916432490357 0.4662706237631778 0.6410218031615118 1.0 0.8381978825951191 3 Q86SF2 1 +14-3-3 domain superfamily [IPR036815] 0.4436826640548437 0.4661902708445656 0.641079312747538 1.0 0.8381978825951191 6 P63104,P31946,P61981,P27348,P62258 5 +Homeobox-like domain superfamily [IPR009057] 0.3368324205741418 0.4331718158618823 0.6648899526241914 1.0 0.8481839395638333 19 P07199,Q99543,Q9NYB0,Q99459,Q96G23,Q96KC8,Q8NB78 7 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.643638418264036 0.4276188558235737 0.6689286356447082 1.0 0.8501250688334042 3 P48449 1 +SWAP/Surp superfamily [IPR035967] 0.4162585700293799 0.3594136784982422 0.719285643471999 1.0 0.8801675611093431 6 Q12872,Q8IWZ8,O15042,Q8IWX8,Q15459 5 +Protein-tyrosine phosphatase-like [IPR029021] 0.3860086881120484 0.3396334494874881 0.7341325849028049 1.0 0.884261836006854 8 Q13614,Q99956,O14976 3 +SMAD/FHA domain superfamily [IPR008984] 0.359638363628662 0.2974768978628742 0.7661024429668299 1.0 0.8986329678037723 10 P85037 1 +R3H domain superfamily [IPR036867] 0.5877364644487809 0.2807203035843504 0.77892493468619 1.0 0.9077841214120534 3 Q9H6S0,O95453 2 +Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068] 0.5800456472122524 0.2296321544607504 0.8183776188153866 1.0 0.924494668030318 2 P43490 1 +SPOC-like, C-terminal domain superfamily [IPR016194] 0.4139635168581932 0.1895226604648729 0.8496831964390983 1.0 0.9537466556938272 4 P12956 1 +Fibronectin type III superfamily [IPR036116] 0.364861849727657 0.1851224762692616 0.8531329727768568 1.0 0.955460812358092 6 O15344,P10586,Q8NAT1 3 +Cyclic phosphodiesterase [IPR009097] 0.542223671340062 0.1572004320634984 0.8750868877976987 1.0 0.9605604907918924 2 P09543 1 +TFIIS/LEDGF domain superfamily [IPR035441] 0.3418217433888394 0.1208040068550504 0.903846276340028 1.0 0.98298489039745 6 Q7Z4V5,Q96ST2,P23193,Q14241,O75475 5 +Ribonuclease III, endonuclease domain superfamily [IPR036389] 0.5132050864036424 0.1135765100534577 0.9095735090977366 1.0 0.9846759089314948 2 Q9H9J2 1 +ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121] 0.4909093394094506 0.1008706171648854 0.919653168217404 1.0 0.9847629965453149 3 P25705 1 +PITH domain superfamily [IPR037047] 0.5024453863710346 0.0999778488425663 0.9203619113821636 1.0 0.9847629965453149 2 O43396 1 +Rhodanese-like domain superfamily [IPR036873] 0.4884873942277523 0.0976979692838074 0.9221721281208244 1.0 0.9847629965453149 3 Q99956 1 +Endonuclease/exonuclease/phosphatase superfamily [IPR036691] 0.4859752120025872 0.0944747513072598 0.9247320382607134 1.0 0.9852675441513696 3 Q6L8Q7,P27695 2 +Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155] 0.4385392892076899 0.0448353875937667 0.9642385182223804 1.0 1.0 2 Q9H267 1 +Nucleotidyltransferase superfamily [IPR043519] 0.3023179888997764 0.033813078782616 0.9730262065496258 1.0 1.0 6 Q12906,P51003,Q96SI9,Q9NVV4,Q96KR1 5 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.4182682310581953 0.0317576772818855 0.974665298233912 1.0 1.0 3 P31689 1 +Ribosomal protein S10 domain superfamily [IPR036838] 0.4062601891098754 0.0304949058732429 0.9756723560176668 1.0 1.0 2 P82664 1 +Mss4-like superfamily [IPR011057] 0.3772416041734622 0.0228843847862534 0.9817424962702568 1.0 1.0 2 P13693 1 +ARFGAP/RecO-like zinc finger [IPR037278] 0.4011741682974371 0.0223684982162903 0.9821540088433748 1.0 1.0 3 Q8N6T3,Q8N6H7 2 +ArfGAP domain superfamily [IPR038508] 0.4011741682974371 0.0223684982162903 0.9821540088433748 1.0 1.0 3 Q8N6T3,Q8N6H7 2 +Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162] 0.3469188131724842 0.0185328470810819 0.9852137738798232 1.0 1.0 2 Q5JTZ9 1 +Ubiquitin-like domain superfamily [IPR029071] 0.2598524267143756 0.0184490271705851 0.985280641059862 1.0 1.0 35 P46379 1 +HRDC-like superfamily [IPR010997] 0.3012716009129498 0.0158878800205396 0.9873238391260508 1.0 1.0 2 O15514 1 +Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069] 0.2821692346250778 0.0062136602758273 0.995042248302644 1.0 1.0 9 P16219 1 +SNase-like, OB-fold superfamily [IPR035437] 0.3325198300965599 0.0023506162074898 0.9981244813468352 1.0 1.0 3 Q9Y2W6 1 +Acyl-CoA binding protein superfamily [IPR035984] 0.3171426014948582 0.0004917114475792 0.999607671043416 1.0 1.0 3 Q9H3P7 1 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..074c6d3148d355cb9d033750fbf4dd81f3877f43 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily [IPR036971]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "5-formyltetrahydrofolate cyclo-ligase-like domain superfamily [IPR024185]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "APC, N-terminal coiled-coil domain superfamily [IPR036149]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit A superfamily [IPR035908]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Actin-related protein 2/3 complex subunit 5 superfamily [IPR036743]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adenomatous polyposis coli protein [IPR026831]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-dystroglycan domain 2 [IPR027468]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Bcr-Abl oncoprotein oligomerisation domain superfamily [IPR036481]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CENP-B, dimerisation domain superfamily [IPR034882]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carbon-nitrogen hydrolase superfamily [IPR036526]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cation efflux transmembrane domain superfamily [IPR027469]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Core-binding factor, beta subunit superfamily [IPR036552]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily [IPR037008]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA glycosylase [IPR011257]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, subunit B, N-terminal domain superfamily [IPR043034]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Daxx, N-terminal domain superfamily [IPR038298]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Dedicator of cytokinesis, N-terminal, subdomain 1 [IPR042455]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "ESCRT-II complex, Vps25 subunit, N-terminal winged helix [IPR014041]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exocyst component Exo84, C-terminal, subdomain 1 [IPR042561]", "Exocyst component Exo84, C-terminal, subdomain 2 [IPR042560]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Fe-S cluster assembly domain superfamily [IPR034904]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP cyclohydrolase 1 type 2/Nif3 superfamily [IPR036069]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Globular protein, non-globular alpha/beta subunit [IPR011070]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase-type carbohydrate-binding [IPR014718]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix-hairpin-helix, base-excision DNA repair, C-terminal [IPR023170]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "LysM domain superfamily [IPR036779]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial ribosomal protein L55 superfamily [IPR044884]", "MoaB/Mog-like domain superfamily [IPR036425]", "Moesin tail domain superfamily [IPR008954]", "Mog1/PsbP, alpha/beta/alpha sandwich [IPR016123]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Ndc80 domain superfamily [IPR038273]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nuclear hormone receptor-like domain superfamily [IPR035500]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAS domain superfamily [IPR035965]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PINIT domain superfamily [IPR038654]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PLP-binding barrel [IPR029066]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Plus3-like superfamily [IPR036128]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinolinate phosphoribosyl transferase, N-terminal domain superfamily [IPR037128]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RRF superfamily [IPR036191]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Rad4, beta-hairpin domain 3 superfamily [IPR042488]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rel homology domain (RHD), DNA-binding domain superfamily [IPR037059]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S16 domain superfamily [IPR023803]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S18 superfamily [IPR036870]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rudiment single hybrid motif [IPR011054]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SAP30, C-terminal domain superfamily [IPR038291]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scaffold protein Nfu/NifU, N-terminal domain superfamily [IPR036498]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/glucose symporter superfamily [IPR038377]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Sodium:neurotransmitter symporter superfamily [IPR037272]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfatase-modifying factor enzyme superfamily [IPR042095]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Telomere repeat-binding factor, dimerisation domain superfamily [IPR036507]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription factor IIA, beta-barrel [IPR009088]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transglutaminase-like superfamily [IPR036985]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 [IPR042522]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 [IPR042523]", "Ufd1-like, Nn domain [IPR042299]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vta1/Callose synthase, N-terminal domain superfamily [IPR023175]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATR", "ATRX", "ATXN10", "AURKB", "BABAM1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAS3", "BCAT2", "BCKDHA", "BCKDK", "BCL2L13", "BCR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BZW1", "BZW2", "C1QBP", "C2CD2", "CAB39", "CABIN1", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPV", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "COA7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCPS", "DCTN1", "DCUN1D1", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM120A", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOPC", "GORASP2", "GOT1", "GOT2", "GPD1L", "GPD2", "GPI", "GPKOW", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCFC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INF2", "INTS1", "INTS12", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "L2HGDH", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "METAP1", "METTL1", "METTL13", "METTL17", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIF", "MIF4GD", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPG", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL4", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL55", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYBBP1A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCBP3", "NCDN", "NCL", "NCOA5", "NDC80", "NDRG3", "NDUFA10", "NDUFA2", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFE", "NENF", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKB", "PIAS2", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLEKHA5", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POMGNT2", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP12", "RRP7A", "RRP8", "RRP9", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTN4IP1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX12", "STX17", "STX3", "STX4", "STX5", "STX7", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFRC", "THEM6", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMA16", "TMED5", "TMED7", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSPO", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS13D", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WNK1", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFC3H1", "ZFR", "ZFYVE16", "ZMYND8", "ZNF277", "ZNF281", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZPR1"], "leading_proteins": ["AARS2", "ABCB1", "ABCC4", "ACADS", "ACBD3", "ACOX3", "ACP6", "ACTN4", "ADD1", "ADK", "AFG3L2", "AIFM1", "ALDH1A2", "ANAPC5", "ANAPC7", "ANKLE2", "ANXA4", "ANXA6", "ANXA7", "APEX1", "ARFGAP1", "ARFGAP2", "ATP13A1", "ATP2A2", "ATP5A1", "ATP7B", "BAG6", "BAIAP2", "BRD2", "CALU", "CASK", "CCAR2", "CDC5L", "CENPB", "CERS2", "CETN2", "CHERP", "CIRBP", "CLUH", "CNNM4", "CNP", "COA7", "COMT", "COX2", "CPSF7", "CPVL", "CRK", "CRTAP", "CTTN", "CYB5B", "CYB5D2", "CYP51A1", "DAZAP1", "DHPS", "DLG1", "DLG3", "DNAJA1", "DNAJC1", "DNAJC2", "DNAJC3", "DOCK1", "DUSP9", "EIF4B", "ELOA", "EPHX1", "EWSR1", "EXOSC2", "EXOSC3", "FCGRT", "FDFT1", "FKBP14", "FKBP7", "FOXK1", "FOXRED1", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "GAA", "GAK", "GALNT7", "GAPVD1", "GBA", "GGA2", "GLA", "GLB1", "GNA13", "GNAO1", "GRSF1", "HDGFL2", "HEXA", "HIP1", "HLA-C", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPLL", "HNRNPM", "HNRNPR", "IGF2BP2", "ILF3", "IWS1", "KDM1B", "KHDRBS3", "KHSRP", "KIAA0391", "KIFBP", "KLC4", "KPNA2", "L2HGDH", "LARP4", "LMNA", "LMNB2", "LNPEP", "LPCAT1", "LSS", "M6PR", "MATR3", "MAU2", "MGEA5", "MIA2", "MICU1", "MICU2", "MID1", "MPP1", "MPP2", "MPP6", "MPP7", "MRPL44", "MRPS10", "MTMR2", "MTPAP", "MYL6", "NAA40", "NAGLU", "NAMPT", "NAP1L1", "NAPG", "NCBP3", "NELFE", "NENF", "NGEF", "NME2", "NNT", "NOL8", "NONO", "NPEPPS", "NRDC", "NRDE2", "NSUN2", "NT5C3B", "NT5DC3", "NUB1", "NUCB1", "NUCB2", "NUP35", "OCLN", "P3H1", "P3H4", "P4HA1", "P4HA2", "PABPN1", "PAPOLA", "PARN", "PCYOX1", "PDE12", "PDE6D", "PDLIM5", "PEF1", "PFDN2", "PFDN6", "PICALM", "PIK3R2", "PITRM1", "PLA2G15", "PLXNB2", "POLR2D", "POMGNT2", "PON2", "PPIL4", "PPT1", "PPT2", "PRCP", "PROCR", "PSIP1", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PSMD11", "PSME1", "PSME2", "PSPC1", "PTBP2", "PTCD3", "PTPRF", "PUF60", "QKI", "RAPGEF2", "RAPGEF6", "RAVER1", "RBM10", "RBM14", "RBM15", "RBM17", "RBM26", "RBM27", "RBM3", "RBM4", "RBM8A", "RBMX", "RBMXL1", "RCN1", "RCN2", "RETSAT", "RMDN1", "RMDN3", "SCAF4", "SCPEP1", "SET", "SF3A1", "SFPQ", "SFSWAP", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A20", "SLC25A21", "SLC25A26", "SLC30A5", "SLC3A2", "SNRNP70", "SPNS1", "SPTAN1", "SRRT", "SRSF1", "SRSF10", "SRSF3", "SRSF5", "SRSF7", "SRSF9", "STAM", "STRBP", "STX12", "SUGP1", "SYNCRIP", "SYNJ2BP", "TAF15", "TAP2", "TCEA1", "TDRKH", "TERF2IP", "TEX264", "TIAL1", "TIMM50", "TJP1", "TJP2", "TPT1", "TRA2B", "TRMT61A", "TTC19", "TTC21B", "TTC26", "TTC38", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TXNL1", "U2SURP", "UNC119B", "UQCRC2", "UTP6", "VDAC2", "VPS33B", "XRCC6", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "YWHAZ", "ZCCHC3", "ZFR"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..4efa69e0d8c7604d94d1da7c20c616ce761fb95b --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:01758257cf36e224f38e1425129a1a554cbd5c9ac9e4a7dd77fbe0073c66aaed +size 67598 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..606a5fd2fee9c23790adf4cce07b6bbef0f88bca --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.25 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..14a29258907afa1ae3fdb3d76b777ae3f730714c --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..88b7ef732aac59945ee226482dd9eb1488b8b008 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.811791978789639 1.95036390939213 0.0511327602837279 0.1893716086798517 0.2045310411349117 5 P35670,Q9HD20 2 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f613eb66155da59cb753c22b2e05d919de515acf --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP7B", "EIF5A", "FASN", "LRP1", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP7B"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..9f29fcc159bf9b6a0f7ff3d0a0b34ad302df1142 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:33cf73677cc2675adbb6dacb43086613a5c61637dcc28836372ff8b55ccdf11e +size 75839 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8d6dd8e626d2374512b9c2dfb37064a154be1c7b --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Annexin repeat [IPR018502] 3 6 2.111824727324483 0.0347014855568634 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 1.0 1.0 0.0003260526470588 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3b5b4d4073bc5d43a75a3f878668528062397070 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 76, + "title": "Average number of proteins per term", + "value": 5.302631578947368 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..37116af54a41bca8673a85ccb99d494af06a914b --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8f4f463401818439d505e45113e960ddbecd3c33 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Annexin repeat [IPR018502] 0.8120931525833728 2.111824727324483 0.0347014855568634 0.9317214208642148 0.174025028374938 6 P08133,P09525,P20073 3 +Mitochondrial substrate/solute carrier [IPR018108] 0.5161081460542108 1.625385185086888 0.1040805106090614 0.9997642548356084 0.3588436328924164 18 Q70HW3,Q9BQT8,O43772 3 +Atypical Arm repeat [IPR032413] 0.5491297275669855 0.8156211684996201 0.4147168384863049 1.0 0.716329084658163 5 P52292 1 +Tetratricopeptide repeat 2 [IPR013105] 0.4200913242009034 0.0328928240279778 0.9737600552971608 1.0 1.0 3 P31948,Q14318 2 +BIR repeat [IPR001370] 0.3104010433648511 0.0161839108292242 0.9870876710823931 1.0 1.0 2 P98170 1 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..21d7ccef31a90571976945991b731f4e7c2fc596 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Adenomatous polyposis coli (APC) repeat [IPR041257]", "Adenomatous polyposis coli protein repeat [IPR009223]", "Adenomatous polyposis coli protein, 15 residue repeat [IPR009240]", "Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "BspA type Leucine rich repeat region [IPR026906]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "SAMP [IPR009224]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN4", "AGAP3", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "APC", "ARMC6", "ARMCX3", "ARPC1A", "ARPC1B", "ARVCF", "ASPH", "ATR", "BIRC6", "BOP1", "BRAT1", "BUB3", "CABIN1", "CAST", "CDC16", "CDC23", "CDC27", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "COA7", "COLEC12", "COPA", "COPB2", "CORO1B", "CORO1C", "CORO7", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DYNC1I2", "EDC4", "EED", "EHMT1", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "ERBIN", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GMPPB", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HTT", "HUWE1", "IGF2R", "IPO4", "IPO5", "JUP", "KAT7", "KDELC2", "KDM2A", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LARP1", "LASP1", "LLGL1", "LRBA", "LRCH2", "LRP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MKI67", "MRPS27", "MTCH1", "MTCH2", "MTPN", "NAA15", "NASP", "NEK9", "NFKB2", "NHLRC2", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NUDT12", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "P4HA1", "P4HA2", "PAFAH1B1", "PAK1IP1", "PDCD11", "PGGT1B", "PHIP", "PIK3R4", "PLAA", "PLEC", "PLRG1", "PLXNB2", "POLR2A", "PPID", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP5C", "PPWD1", "PREB", "PRKCSH", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABGGTA", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RBBP5", "RCC1", "RCC2", "RNH1", "RPAP3", "RPTOR", "RRP9", "RSU1", "SART3", "SCML2", "SCRIB", "SEC13", "SEC31A", "SGTA", "SHOC2", "SIN3A", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SPTBN2", "SRP72", "STIP1", "STRAP", "STRN", "STUB1", "SUGT1", "SYNE2", "TAGLN2", "TBL2", "TBL3", "TEX10", "THOC3", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TPBG", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "VPS18", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR75", "WDR77", "WDR82", "WDR91", "XAB2", "XIAP", "XPO1", "YTHDC2", "ZFC3H1"], "leading_proteins": ["ANXA4", "ANXA6", "ANXA7", 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6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 0.0063974382633619 0.3154415256826839 0.0009174672207126 0.0121528015183308 0.0015604872334513 +Plasma lipoprotein particle clearance 3 11 2.655269378013294 0.0079245098782647 2.8033980582524274 11.597087378640778 0.2841472336869506 0.2922439265613805 1.7215617505529983 1.5431625772865891 1.3638326625090953 0.2354738993646769 0.0343508900176433 0.0039064712270754 0.0149285353010988 0.0011461563975241 0.0142025885279179 +Peptide catabolic process 3 10 2.627733255774569 0.0085955888590583 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 0.0001468608330537 0.0858288536093336 2.566766913529817e-05 0.0009343298569185 0.0017273216459823 +Lytic vacuole organization 9 22 2.6210941450415453 0.0087648053882287 8.677184466019417 23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 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0.0012201132329283 0.0011621905058569 0.0025531684631581 +Transition metal ion transport 7 13 2.551107558472065 0.0107381180853489 4.70873786407767 14.08980582524272 0.8861898222657586 0.2678437025860737 2.4756329698054333 2.718007722894407 1.3738160036140448 0.271065502827487 0.2153041836423196 1.0 0.4286451954700402 0.0523525024013737 0.0072152122103698 +Mitochondrial calcium ion transmembrane transport 4 11 2.5321702030224102 0.0113358951359325 3.4684466019417477 9.04126213592233 0.7792467211325117 0.2463779000555085 2.196969341156949 1.2010296388602075 1.3738174116662032 0.263849842646199 0.2112540265048064 0.0727733471903131 0.1405588989726414 0.000464221556229 0.000732082482726 +Inner mitochondrial membrane organization 8 22 2.530843955577731 0.0113788458709094 9.985436893203884 20.800970873786408 1.138268089020681 0.2873707765098114 4.6289277788641146 2.4012939531921327 1.609232985153232 0.3229583948801056 0.0168270257414759 1.0 0.2957660567507726 0.0113755989576282 0.0081074498059467 +Ph reduction 4 12 2.5265989993332343 0.0115172922828654 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 4.821236860073059e-05 8.147714785824873e-06 5.516182599842101e-06 0.0004717775355386 0.0018986041281287 +Ceramide metabolic process 8 19 2.516846937929128 0.0118410257307834 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 0.0513182130916121 1.0 1.0 0.0114704454362887 0.0015404887619569 +Cellular monovalent inorganic cation homeostasis 4 25 2.513994783310485 0.0119372199624712 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.0019773046812529 0.000185314654978 0.0002613150729152 0.0150960472167561 0.0739124968095968 +Low density lipoprotein particle clearance 3 10 2.5099870184807966 0.0120735599976418 2.628640776699029 10.633495145631068 0.2652848599989675 0.2775304047094778 1.52978680445189 1.394909057645927 1.3932465899654711 0.2286950604253255 0.0225400063340814 0.0024970154667983 0.0096613748096581 0.000464221556229 0.0062187451165004 +Protein targeting to mitochondrion 8 48 2.50918782936544 0.0121009120584911 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 5.393015686265841e-06 0.008121261283644 0.0001732623785397 0.0002446655774609 0.0033682884996015 +Protein transmembrane transport 6 25 2.4941904344613417 0.012624479297149 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 0.0001190822178622 0.0019447965050573 0.0015183657514178 0.0002485908401435 0.0037131193455902 +Regulation of plasma lipoprotein particle levels 3 14 2.4637386579402043 0.0137496324427881 3.0485436893203883 14.031553398058252 0.231208625789076 0.3303314046534408 1.822878555656895 1.834532430195746 1.3070593144112836 0.2560846117575656 0.0757599364754171 0.0092510900433489 0.034177713847331 0.0060587135875955 0.0608861307148366 +Regulation of response to osmotic stress 1 5 2.4604583030316616 0.0138759694949326 1.555825242718447 4.723300970873787 0.5624657056224166 0.335781854721921 0.9825121598317113 0.6618162540137008 1.18971814204224 0.2760935752136865 0.1378063248599364 1.0 0.0903020002145616 0.0226124222523767 0.0814729797756298 +Ceramide transport 1 5 2.458743347228952 0.0139424250742932 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 0.01507861609806 0.0595353304203936 0.0063961411835862 0.0373951204607401 0.1285045320310699 +Pigment metabolic process 5 27 2.448783814710627 0.0143339452140858 6.730582524271845 27.429611650485437 0.7330558837492486 0.3938325994367372 3.1680652652278396 2.973572406869117 1.1788232115476622 0.3357800616079686 0.0012406725098023 0.0001236423181942 0.0017432967444755 0.0019197523956069 0.0162593146466844 +Regulation of ph 4 20 2.43716620415742 0.0148028738126126 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.0009601979655909 9.916625654639606e-05 0.0001220374557122 0.0078371753722585 0.0387569851109487 +Regulation of cellular ph 4 20 2.43716620415742 0.0148028738126126 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.0007298412432187 7.841716015047822e-05 9.15562279738178e-05 0.0060920571940213 0.0300212330028383 +Organophosphate ester transport 8 29 2.409439815049606 0.0159770309992717 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.0060679699285667 0.0531691841805127 0.0064708018379125 0.0114639670330544 0.0138176509590574 +Monovalent inorganic cation homeostasis 4 28 2.398705729739301 0.0164531311086852 9.014563106796116 27.87378640776699 1.1567920478867002 0.2845186374336156 4.051822262152646 3.607380814764068 1.4117439861533438 0.3149022278800241 0.0043376016201349 0.0003708570183047 0.0006036808079391 0.0303284382430454 0.1416215981894753 +Regulation of lymphocyte apoptotic process 3 8 2.397868612752297 0.0164907791879862 2.029126213592233 7.381067961165049 0.4739111260724032 0.458828678896727 1.5277771827044868 1.703203955440417 1.0212880846326546 0.3148137372778026 0.3201079280732647 0.1155957163384056 0.2182850433665622 0.1275304084592042 0.0349002560689848 +Response to oxygen levels 7 59 2.3869447356078517 0.0169890449146006 12.5 62.737864077669904 0.8042614609462893 0.4659445696529398 5.042296826006319 7.106965221607376 0.959407798819026 0.3671515409983293 0.00762515698864 0.0002695237413997 0.0004557436076154 0.042352166056522 0.1437641929522751 +Anion transmembrane transport 12 44 2.365396741853007 0.0180107649906688 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 0.0002379535332828 0.0155956893556562 8.521434535907279e-05 0.0053741303197697 0.0029154401822159 +Blood vessel endothelial cell migration 2 21 2.3632348683032105 0.0181161842596451 4.536407766990291 22.449029126213592 0.7681724367497832 0.3963490094539818 2.4704338498615206 2.406468634828595 1.0319905271466427 0.3120666413936225 0.0838566849413369 0.0042974194252635 0.0281263938020361 0.2348605510084629 0.4421670228783916 +Regulation of glial cell proliferation 1 5 2.3564492791814637 0.0184505871423779 0.9563106796116504 4.089805825242719 0.9341050469143442 0.3274204875894432 0.8829748814899869 0.9675276073756384 1.0425311720733597 0.2839327622585455 0.0253021270616913 1.0 1.0 0.0612683946998099 0.1979724457266636 +Chromosome organization involved in meiotic cell cycle 3 16 2.344842625732235 0.0190351121930567 4.191747572815534 17.075242718446603 0.5477868656890444 0.537972059729365 2.504293372491294 1.9587168103198336 0.797047721972746 0.3210313218702831 0.1025820284495844 0.1604648724397155 0.2957660567507726 0.0113755989576282 0.1023001003732698 +Calcium import into the mitochondrion 4 8 2.344619347610943 0.0190465136954069 2.4563106796116503 6.04126213592233 0.8091317576129835 0.2214807715451704 1.7082137325011066 1.2010296388602073 1.3762222767333927 0.2421218388926935 0.1630140709510483 0.0550816697898294 0.1073692926764015 0.0001361645754707 0.0001560226497295 +Regulation of necrotic cell death 3 12 2.343605775577116 0.0190983459705107 2.6771844660194173 11.71359223300971 0.2977530378262362 0.4578180986081704 1.5454800476301118 1.252380145124011 1.0198350476395044 0.2956255904252384 0.0593823547763923 1.0 0.2256640636042331 0.0259302086121007 0.0394546172777071 +Negative regulation of macroautophagy 1 10 2.3288674615403537 0.0198660881744914 2.657766990291262 11.342233009708735 0.5734063046472396 0.4235310399182105 1.9797182461289764 1.5349845399675808 0.9579244223739132 0.2955499758703153 0.0757599364754171 0.1362745587685063 0.2544971315679337 0.1691905711971676 0.4472297830188122 +Lysosomal protein catabolic process 3 6 2.3217981448548923 0.0202438072020612 2.6941747572815533 6.587378640776699 0.838918419522322 0.2080383809566978 1.5899151374262637 1.8707342212441815 1.5239608036504366 0.2420459791980847 0.002165465243986 0.0814971443263516 0.0121688129697343 0.0084670093197957 0.0096830476876922 +Protein catabolic process in the vacuole 3 6 2.3217981448548923 0.0202438072020612 2.70873786407767 6.618932038834951 0.8383076008345888 0.2101105309103242 1.6017652153393662 1.88837291272598 1.5176899437744062 0.242508547144668 0.002960859746303 0.0901405579438761 0.0149285353010988 0.0114205450108361 0.0142025885279179 +Porphyrin containing compound metabolic process 4 18 2.3084350829976983 0.020974949585135 4.91747572815534 16.531553398058254 1.0269348271542438 0.279733852070357 2.276512713100022 2.089380108414912 1.2578863722796805 0.2914421038569487 0.0016526705472041 0.0005765764868268 0.0042562107320329 0.0013598100665948 0.0255449311307142 +Mitochondrial calcium ion homeostasis 8 11 2.3048890958326256 0.0211727854617036 4.62621359223301 10.509708737864075 0.2790428491871666 0.3774917598770124 2.1634860921400008 1.7383182679254283 1.294226020505384 0.3175561312397286 1.0 1.0 1.0 0.0130923880875091 0.0027898710574492 +Membrane raft organization 2 9 2.299930102973542 0.0214521803130856 2.533980582524272 8.924757281553399 0.544342121241576 0.3623081632411893 1.688427394821621 0.9935074131191508 1.097645488795839 0.2730349650970456 0.0018241008785546 0.0771453392642774 0.0108829135912838 0.007181114657122 0.046330877355434 +Vacuole organization 14 51 2.2900370130445324 0.0220191711186836 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.0268090691299787 0.0362209672326423 0.015374207145476 0.0040531766134387 0.0034150956473202 +Membrane lipid biosynthetic process 7 23 2.283772129964376 0.0223849264111613 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 0.3404977061644203 0.3219228357858488 0.5410608871602637 0.1331395664600213 0.0445077381794537 +Homologous chromosome segregation 2 9 2.283468641594156 0.0224027779715518 2.9441747572815533 9.983009708737864 0.8658101820521615 0.3886675393312038 1.6544409340956687 1.448870557748215 0.8756753907408087 0.3062582021532934 0.3497529888008241 0.1280604643503683 0.2402159343378795 0.0312870079093941 0.163813839479234 +Protein localization to mitochondrion 20 61 2.2811649002078216 0.0225386908970146 18.37621359223301 58.6747572815534 1.743973973786015 0.2835887708870952 7.329731795051445 5.553888141183353 1.6030721833013164 0.3628376459321563 2.876625361333737e-05 0.0141530490628759 0.0005261629610908 0.0002540163016573 0.0021058694172725 +Lipoprotein localization 3 7 2.278711299255725 0.0226842326244431 1.7451456310679612 4.762135922330097 1.33870340128666 0.2150435313503844 1.1193794779630346 1.3835803073772095 0.999398972942542 0.2555578059866495 0.0128820657469678 0.0550816697898294 0.1073692926764015 0.0001361645754707 0.0019736987849612 +Negative regulation of leukocyte migration 2 6 2.2611224485683006 0.0237516756401257 1.5655339805825244 6.388349514563107 1.0839414642274992 0.2862432737648586 1.19995002173864 1.2770035444730965 0.9459956297737524 0.2624453160295969 0.0225400063340814 0.0024970154667983 0.0096613748096581 0.0549051852836066 0.0395358442373242 +Homologous chromosome pairing at meiosis 2 8 2.246325267149776 0.0246831812810537 2.4975728155339807 8.245145631067961 0.965829654578573 0.3348869860078453 1.4047402178514554 0.97323438747629 0.9242483632276672 0.2995534430572119 0.2567311256711848 0.0901405579438761 0.172526836456327 0.0114205450108361 0.0698565063333662 +Glial cell proliferation 2 6 2.2393088249373205 0.0251358290742436 1.6262135922330097 5.412621359223301 1.1035845317400614 0.2421873681292294 1.0594430818589295 1.1842969002295405 1.0977939547178823 0.257309212646388 0.0444546103480301 1.0 1.0 0.1039226879692455 0.097693310147501 +Response to food 2 5 2.2223986399161224 0.0262563771784143 1.720873786407767 5.783980582524272 1.3281223897944048 0.1823213242558801 0.9790282548915298 0.8299231919143666 1.0823564620426191 0.211054619984942 0.0008010388158447 1.0 0.0002160518736796 0.0032412641391043 0.0224777557227792 +Regulation of toll like receptor signaling pathway 1 9 2.2196292798105164 0.0264439430244978 2.587378640776699 9.50485436893204 0.9772136844316576 0.3297728067967737 1.666236944633112 1.8466647258935645 0.9012634534298872 0.2761306672489575 0.1265959661018035 0.1801156574188796 0.0592322030833591 0.2661072893157929 0.6107504391665564 +Tetrapyrrole metabolic process 4 21 2.2161793521448976 0.0266792213922617 5.652912621359223 19.283980582524272 1.0342508202848784 0.290677507336007 2.6828141040028877 2.549402305664568 1.2308389507353266 0.2976223887279709 0.0038685933897715 0.0011325878612279 0.0081036074971322 0.0038209909550562 0.0601700233302374 +Smad protein signal transduction 4 10 2.208944034844184 0.0271785338236791 2.9223300970873787 8.470873786407767 1.0610232243819884 0.2706100861951009 1.609675360071813 0.9712499271368484 0.9663464864325269 0.2495327076802485 0.0193759682694979 1.0 0.0519022265935445 0.065867090511777 0.0387405426335318 +Regulation of b cell apoptotic process 2 5 2.205116832575807 0.0274458971962769 1.2888349514563109 4.143203883495145 0.4712803824401109 0.4838259091452473 1.0979113453615192 1.1000341685710282 1.0371325316664826 0.3279009485506359 0.1753420255248594 0.0595353304203936 0.1157837219692003 0.0373951204607401 0.0224777557227792 +Response to increased oxygen levels 2 10 2.2033450432577077 0.0275704384937303 1.9563106796116505 8.939320388349515 0.9100937072347148 0.3197058737817761 1.2933864561055997 1.001798152387997 1.0059424935454593 0.2746313949658078 0.002960859746303 0.0001055314719321 0.0008209706516698 0.0114205450108361 0.0698565063333662 +Regulation of leukocyte apoptotic process 3 12 2.202581269981904 0.027624275247635 2.936893203883495 11.74514563106796 0.2085778692691842 0.4643574261341155 1.8264236522577744 2.223135354411492 1.0583074377406043 0.2953853498886979 0.4719828760267527 0.1839914155878272 0.3347729381598622 0.2750356519407824 0.1534735865665994 +Regulation of lysosomal lumen ph 2 5 2.19356654117689 0.0282665860011888 2.3567961165048543 5.58252427184466 1.1719038900849827 0.159040563248536 1.2351555175791742 1.4280428037740598 1.4707016211600112 0.2132438131163355 0.0012471501322576 0.0021914548918381 0.0003390497899834 0.0049774684437096 0.033288888151673 +Mitochondrial respiratory chain complex assembly 8 41 2.177825602233151 0.0294190230567379 14.427184466019416 38.300970873786405 1.6683402305651691 0.229838901803248 5.648441561419256 5.588363345618 1.6629328950455762 0.3088219725228932 0.0003737342037705 1.0 0.0105698120020729 0.000315408582109 0.004373749906664 +Organic hydroxy compound transport 7 31 2.175993668482817 0.0295557339970431 7.145631067961165 30.32766990291262 0.3121985122058121 0.5028073494895335 3.2773354290298986 4.4061862301676955 1.0194405540894098 0.3270691777029814 0.0053624322863327 0.4037553510187831 0.2739830091088552 0.0155851459880544 0.1582264017157612 +Carbohydrate derivative catabolic process 17 36 2.175054915462378 0.0296260014158853 9.92233009708738 34.20388349514563 -0.0123085756499559 0.2707665028006943 3.843893961107642 3.291233496452993 1.7787241070250257 0.2878972939517332 0.0066536890044188 0.4178101866251551 0.2914606489381419 0.0016220472170808 0.0011850154453525 +Excretion 0 5 2.173665933982124 0.0297302328055397 1.269417475728155 5.201456310679611 0.6776908500633984 0.3886507914896875 1.1481249595760017 0.8622041158633096 0.9714806682442636 0.2826040335002768 0.2456121138851051 0.0858288536093336 0.16464692140167 0.3691131537615641 0.611110604791141 +Sphingolipid biosynthetic process 7 17 2.172976797127774 0.0297820636653358 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 0.5839504292305713 1.0 1.0 0.1672011263097502 0.0231914212352716 +Cholesterol efflux 3 8 2.1717926612171703 0.0298713054847377 2.5485436893203883 7.621359223300971 0.5111997846274834 0.3340620166024763 1.4780178328121285 1.039197831548229 1.1947983633918562 0.2643278716774433 0.0070473093034586 0.1197698958477507 0.2256640636042331 0.0036412042541821 0.0394546172777071 +Regulation of membrane lipid distribution 3 9 2.16172350432209 0.0306394948093742 2.2475728155339807 5.5 0.9490281853542848 0.2470521989607894 1.5110816970578842 2.070950253254846 1.235309366119274 0.2447223644308076 0.3301358347374786 1.0 0.2256640636042331 0.1356584244478134 0.0394546172777071 +Regulation of response to extracellular stimulus 1 5 2.1470539535875046 0.0317889865343821 1.0364077669902914 4.466019417475728 1.2416795343104177 0.2058666180593168 0.8221064046230258 0.7766686887277909 1.0462594039989206 0.2178110962907249 0.0108388682866037 1.0 0.0045656876518621 0.0272068705655749 0.0964811850177102 +Toll like receptor signaling pathway 3 13 2.1450252150812976 0.0319508309975693 3.6529126213592233 14.475728155339803 0.4591583663944621 0.4629288770135975 2.064121680704246 2.5201890058346033 0.9793418922124256 0.3026110620517385 0.0866548046012205 0.2855170484549717 0.0291718268289248 0.2412516167919715 0.4530314357267467 +Xenobiotic transport 3 6 2.138346233712648 0.03248865275979 1.693827160493827 4.08641975308642 0.9732407293076591 0.2870054952103567 1.1547374966527622 1.4159369001791104 1.1259148135419206 0.2680466782257013 0.002960859746303 1.0 0.0149285353010988 0.0011461563975241 0.0142025885279179 +Prostate gland development 0 5 2.137372821307686 0.032567680185247 1.6092233009708738 5.975728155339806 0.8122203292357496 0.3302673624761357 1.2128808594676108 0.7270055647304389 1.0647320376486975 0.2858771068016162 0.368799367492152 0.1362745587685063 0.2544971315679337 0.5285776534016062 0.7860244321290839 +Regulation of b cell activation 5 17 2.136093809517837 0.0326717682460502 4.223300970873787 16.516990291262136 0.0577495350333673 0.5689697369892935 2.5301369502630555 2.1860552471506893 0.9138021371463246 0.3063589445117784 0.2370409021270574 0.0353307530420815 0.1185972912859252 0.4472898261551224 0.0835828069359343 +Cellular response to chemical stress 20 81 2.132967739613985 0.0329273727016816 15.75728155339806 79.70145631067962 0.402779466671678 0.6562176319163813 6.265123092751621 7.907578877532739 0.7656094121344978 0.3407433272819883 0.060601736527803 0.3072922687180656 0.3866964561646477 0.058634246651475 0.0054885557153173 +Rna stabilization 6 26 2.131076009630002 0.0330828807618139 9.359223300970871 27.37621359223301 0.4792302048577673 0.5262457931829767 4.411160534464403 1.6856669427134765 1.0994939820726763 0.3614208213771557 0.1621043050744973 1.0 1.0 0.0292510188996729 0.0022373634783845 +Regulation of pattern recognition receptor signaling pathway 3 18 2.1260636149345435 0.0334979630077851 4.691747572815534 19.70873786407767 0.80673262224624 0.4173389113947272 2.517825740704142 3.173406084005513 0.919675411949683 0.3119180769844089 0.0629569653281197 0.2543128795765555 0.0205010816622888 0.1850761736441579 0.3535912843138049 +Gland development 14 65 2.1216135895510013 0.0338702002575577 13.315533980582524 70.03155339805825 0.3377251159437185 0.619362793080585 5.179070225840264 7.6825027851127485 0.7642435987942063 0.3217888637120522 0.049233167295949 0.1379235125017981 0.0443877531639325 0.2106946987558238 0.3502049690780733 +Positive regulation of b cell activation 4 11 2.117384597316413 0.0342272203449645 3.092233009708738 11.186893203883496 0.1859276114166038 0.5045227221699764 1.8118375224733587 1.264344128777142 1.0073127631140006 0.3002532228225043 0.1168335617053256 0.0151070197534971 0.0543070281832774 0.248255253712859 0.0425821240391988 +Carboxylic acid transport 10 35 2.109503666132694 0.0349011299036605 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.0192222833074899 0.3922727602504912 0.0171213194947106 0.1070430621978471 0.012589375706215 +Myelin assembly 0 7 2.1020950000867664 0.0355449547860986 1.3810679611650485 5.334951456310679 0.6604549552139052 0.4058185332666181 1.1354528736988552 1.290157568299922 0.9729130679543696 0.2930816724161147 0.2456121138851051 0.0858288536093336 0.16464692140167 0.3691131537615641 0.611110604791141 +Regulation of neuron projection development 10 69 2.0947668808488995 0.036191720575649 13.592233009708735 69.32038834951456 0.4627708713262993 0.6269884749906404 5.824182751460114 9.346058399998094 0.798447623110489 0.3496779713708587 0.2117778933181315 0.1357693624302005 0.2537492456224017 0.2048860472695824 0.7733504250043836 +Positive regulation of necrotic cell death 2 6 2.081195036529945 0.037416057689336 1.577669902912621 5.262135922330097 0.5638344924795549 0.4335998879538771 1.168471912149588 0.9650309623137224 1.027471527178098 0.3152978961085739 0.0089540270958906 1.0 0.0903020002145616 0.0226124222523767 0.0105083517934163 +Cellular response to exogenous dsrna 2 8 2.0797780905686976 0.0375458915785564 2.0024271844660193 6.310679611650485 0.5972141116779991 0.4087076192050926 1.2570167843566007 1.13871948363056 0.9497773470751724 0.2837402345544956 0.2112540265048064 1.0 0.1405588989726414 0.3214791435692521 0.0395358442373242 +Amyloid precursor protein metabolic process 14 22 2.07851664744346 0.0376617992175842 5.91747572815534 20.04368932038835 1.2306110398413417 0.2828388345239639 2.574706211328507 3.0661056512526157 1.0127867956133585 0.2841981221806073 0.1937750055582915 1.0 0.4064849903072076 0.1442380851152787 0.1264250298394598 +Negative regulation of neuron projection development 5 19 2.076020098109368 0.0378920922041852 4.944174757281553 19.932038834951456 0.8070712719008988 0.4165241941447024 2.3357271686464363 2.7475042016888107 0.8484003015222881 0.3001902418041021 0.0312952161908096 0.3186897272236745 0.1770920503195545 0.0444713850909232 0.1983116268421612 +Iron ion homeostasis 5 17 2.0703270235371325 0.0384217306109848 4.468446601941747 17.140776699029125 1.0306963602610326 0.26770320823289 2.1032740346004313 1.762496954108992 1.1437451534606062 0.2692749918411525 0.0065794538566726 9.185433074135597e-05 0.0013144952372619 0.0072211895250916 0.0109403402937121 +Respiratory chain complex iii assembly 1 6 2.0694901882592927 0.0385001111112459 1.8470873786407769 5.160194174757281 1.360931378136811 0.1995688008303064 1.0650749835200868 1.2360161344522411 1.0120439004969468 0.2366879233397748 0.0056799964121837 1.0 1.0 0.0145201629780082 0.0540238893245918 +Transition metal ion homeostasis 7 26 2.0692784508269857 0.0385199646030802 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 0.0063974382633619 0.0005260552703788 0.0067630826071128 0.0029683417142342 0.0050801582854678 +Deoxyribonucleoside triphosphate metabolic process 2 8 2.0574855029445365 0.0396395479990294 2.3106796116504853 8.283980582524272 0.37885565145774 0.3611791401950917 1.8009119923381658 1.1145270578724225 1.2279981659947377 0.2841942772074602 0.01507861609806 0.0595353304203936 0.1157837219692003 0.0032412641391043 0.0224777557227792 +Modified amino acid transport 2 5 2.057206824202707 0.0396663354008275 2.029126213592233 5.587378640776699 1.6181581718562612 0.1578136127091599 1.2124460606928238 1.444653995706506 0.7704353439327314 0.2037484924456972 0.002960859746303 0.0901405579438761 0.0149285353010988 0.0114205450108361 0.0142025885279179 +Protein insertion into mitochondrial inner membrane 1 7 2.0532510014190457 0.0400482403304554 2.45873786407767 5.665048543689321 0.6692509200083531 0.3406754428009103 1.501050234026552 1.645659707056692 1.2686438529444872 0.3125184360343283 0.0128820657469678 1.0 0.1073692926764015 0.0321406810264541 0.1121927202905578 +Carbohydrate derivative transport 3 19 2.0500242153969586 0.0403620678338638 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 0.004546256717719 0.019691222561341 0.0091635953837745 0.0238045980839492 0.0702989298923652 +Negative regulation of cell population proliferation 24 90 2.049364249226125 0.0404265103793941 19.383495145631063 97.08252427184466 0.1581356625225672 0.7238624266901581 7.86528068228601 11.547200956886966 0.6889214696860141 0.3091925248352111 0.3770163051997307 0.2922361078775662 0.3262579347767135 0.6261759615860354 0.387858262880668 +Necrotic cell death 3 16 2.040962857844044 0.0412545190607041 3.6237864077669903 16.944174757281555 0.2461941956477482 0.5510613750268976 2.2472674308668004 1.8233358015428889 0.8877495194678131 0.3100933534844365 0.1315480050195343 1.0 0.3347729381598622 0.0830758556110395 0.1534735865665994 +Meiosis i cell cycle process 3 16 2.0359073674656063 0.04175965788368 4.424757281553398 19.196601941747577 0.2772784498983839 0.6314315125632272 2.807180233511531 3.286141554662213 0.6809152194023591 0.283244242032616 0.2916950701687761 0.2922756805728106 0.4999495019072014 0.0972643629189703 0.4745450824854482 +Regulation of systemic arterial blood pressure 1 6 2.031713258815018 0.0421826928627806 1.9514563106796117 7.480582524271845 0.6591644372092078 0.3227631999327531 1.1543807719023411 1.5318976272183211 1.1594175747176596 0.2663405748898474 0.067403767536045 0.0081256981844374 0.0302041354108555 0.1522397567045821 0.163813839479234 +Negative regulation of autophagy 5 25 2.0260637501036185 0.042758252227772 5.063106796116505 24.313106796116504 0.449887145270975 0.5377284095479077 2.9855473971181983 2.929018368027943 0.8516059018543028 0.3205218740462018 0.0168563802817941 0.2718096468929847 0.4705382708629992 0.0762881719720865 0.1049108107264387 +Membrane raft assembly 0 5 2.018963414802259 0.0434910221967059 1.825242718446602 5.54126213592233 0.3242922800041586 0.4831131926691757 1.4954765741415683 0.7378441170013461 0.9268315252335644 0.2950637301306011 0.111844602183839 1.0 0.0729118409275157 0.1762127444605205 0.3279667038186614 +Protein maturation 21 65 2.0182289496867645 0.0435674224447826 16.635922330097088 69.29611650485437 0.7279397561088901 0.5092233260742579 5.6828366082703345 6.923625268615643 1.0037762420957868 0.3621314209884535 0.0096276916813498 0.6163162766509123 0.0409988827198263 0.0226736993994468 0.034867560299335 +Ceramide biosynthetic process 4 11 2.013139621054313 0.0440999430464206 4.033980582524272 10.24757281553398 1.048715387316577 0.2344614502118888 2.237979905601341 2.0281678881596505 1.4071730245015133 0.2685344998940062 0.4052453205547085 1.0 1.0 0.0505229741835546 0.0255449311307142 +Response to oxidative stress 24 94 2.012701591033387 0.0441460319140427 18.145631067961165 95.9757281553398 0.5057872201816154 0.5358657948719677 6.785060354870026 9.30128883458378 0.9511882590088212 0.3606217523881886 0.0112314208586983 0.158963117865429 0.0204016023711585 0.0238923502869626 0.0082201294947124 +Protein import into mitochondrial matrix 1 8 1.9998731123962032 0.0455139672037629 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0199123159742315 0.0021914548918381 0.0085055091795532 0.048794410492492 0.033288888151673 +Membrane lipid catabolic process 6 12 1.998716765085014 0.0456390080100865 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 0.0343508900176433 0.0901405579438761 0.172526836456327 0.0114205450108361 0.0022125190482932 +Aminoglycan metabolic process 7 14 1.9956549053667991 0.0459714987287829 6.650485436893204 15.218446601941748 0.5538240398360251 0.1973407167351751 2.4739761552565955 2.4752855115427597 1.8355272359461776 0.2521795038965069 0.0629569653281197 1.0 1.0 0.0607704003135235 0.180606968360344 +Regulation of endothelial cell migration 5 27 1.993551911534116 0.0462010450996444 5.495145631067961 27.978155339805824 0.5955926179251096 0.4502618340992453 2.841693008322481 3.167187428757454 1.0132828172462562 0.3207559953771818 0.1934416713307095 0.0124618639443786 0.073018222895997 0.2329387736847062 0.3822197372867044 +Intracellular protein transmembrane transport 4 21 1.9855134784611457 0.0470873720415465 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 0.0041981932247113 0.018891152845815 0.0086239941031961 0.0042163593313455 0.0205399046658008 +Nuclear pore organization 6 12 1.9854493737544088 0.0470944973868627 3.995145631067961 12.49271844660194 0.4246677694998982 0.4445771703419001 2.613440935334279 0.6093489987528347 1.0548914640880422 0.3148672191077474 1.0 1.0 1.0 0.2702644522094949 0.0002434795729679 +Sensory perception of light stimulus 4 15 1.982873826301333 0.0473815249429003 5.009708737864078 15.96359223300971 0.918103407248628 0.3572194322029593 2.4583724414330383 3.147064390877318 0.9947617981182544 0.3055434177582076 0.2534224043145359 0.0384617608576108 0.1279773730763402 0.2096344486345477 0.2148519458953993 +Chloride transport 3 14 1.9823235446489524 0.0474430405030206 4.33252427184466 12.12621359223301 1.0302584084066435 0.2341882174183942 2.3624510960969567 2.26059366569241 1.2797232968088257 0.2563105728143979 0.0123294800950985 0.1444128696349771 0.003596499941198 0.0075913906038388 0.0202035082798241 +Liposaccharide metabolic process 7 16 1.9816778060496547 0.0475153127456828 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 0.0535543299750337 0.2400196775334175 0.4231831300186898 0.1613613657695527 0.0606738093858884 +Sterol transport 5 23 1.980148883144886 0.0476868017029492 5.516990291262136 23.23058252427185 0.3564989162781894 0.4550431454343515 2.7566693478017315 3.339632072416373 1.1016145306573315 0.3225081354886266 0.0177104249144926 0.2752604452820565 0.4755563699807594 0.0231451586112089 0.1106465000297166 +Bone morphogenesis 4 7 1.9782809181050296 0.0478970245539727 2.3737864077669903 7.519417475728155 0.7918915806069479 0.3290665752918499 1.3241931901591228 1.4011478132752644 1.0549507058478411 0.2731796281548322 0.4874701889407564 1.0 1.0 0.6645812069305238 0.0651237881613715 +Protein targeting 32 108 1.9644718219841824 0.0494754009136479 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 8.180753412081397e-05 0.0062759976095487 0.0024747255598386 0.0003450393093831 0.0004892376868877 +Positive regulation of protein deacetylation 2 6 1.961588625980828 0.049810397548583 2.7766990291262137 7.635922330097087 -0.1685079130368919 0.5653342148373875 1.657182301758377 1.1980853956737014 0.8228720203048644 0.2922531451725298 0.2456121138851051 1.0 1.0 0.0746908244780269 0.0615084186624239 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..12cb63306a412462262d2dae72b2faf04925b943 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 6394, + "title": "Average number of proteins per term", + "value": 18.625117297466375 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f9f7e8f7777d3c8381e0b838b37dceddccbb6318 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2168d6255562d2daf6a7e67830ee125296fef021 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1656 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sphingolipid metabolic process 0.6814703251578363 3.208457151814597 0.0013344919239484 0.9998042045114508 0.467310963378482 28 P07602,Q99805,P16278,Q96G23,Q06136,P06865,P06280,Q8NCC3,P50897,Q13510,O15121,P27544,P04062 13 +Regulation of blood pressure 0.7532847863491912 3.1137604725005885 0.0018471938286768 0.999992657853772 0.467310963378482 18 Q9HB40,P42785,P09601,P42892 4 +Mitochondrial transmembrane transport 0.5717842405718615 3.041281464665775 0.0023557350280252 0.9999997177123904 0.467310963378482 52 O95831,Q99595,P25705,O43772,O75964,O75027,P23786,P00846,Q8WWC4,Q9BQT8,Q9H4I9,O60830,P21796,Q9BPX6 14 +Membrane lipid metabolic process 0.6321701405661128 3.003938503215973 0.0026650918823341 0.999999961141745 0.467310963378482 36 P07602,P04062,Q99805,P16278,Q96G23,Q06136,P06865,P06280,Q8NCC3,P50897,Q9P035,Q13510,O15121,P27544,Q8NBX0 15 +Mitochondrial transport 0.5023868069469424 3.001099868277827 0.0026900632323416 0.9999999668903408 0.467310963378482 85 Q8N4H5,Q99595,O43772,P25705,P00846,P30536,Q9NS69,Q9Y584,O60830,P45880,P55786,Q96EK5,O95831,P62072,O75964,O75431,P23786,Q8WWC4,Q5JRX3,Q9UBX3 20 +Anion transport 0.4840132753963528 2.924999278679963 0.0034445702160592 0.9999999997379804 0.467310963378482 73 P14174,O43865,Q15043,O15439,P30536,Q8TDW0,P45880,P51790,P21796,P07602,Q9Y277,Q9UHG3,P08183,P53985,Q6N075,P41440,P30825,Q9H2J7,Q9C0H2,Q9BQT8,Q9UBX3,O43681 22 +Vascular process in circulatory system 0.6166935961375493 2.7958324314647354 0.0051766232893064 0.999999999999996 0.467310963378482 31 P41440,P30825,Q07954,O15439,P42892,P08183,P53985,Q9HB40 8 +Vacuolar acidification 0.8760642708954465 2.783870567391149 0.0053714464478811 0.9999999999999988 0.467310963378482 9 Q93050,Q9Y487,Q8N511,P50897 4 +Phospholipid transport 0.717390333535391 2.7295568260423373 0.0063419517848928 1.0 0.467310963378482 15 Q96GC9,Q14108,Q8WTV0,P08183,Q9Y255 5 +Cytochrome complex assembly 0.7519313190834861 2.727744942805 0.0063768893896898 1.0 0.467310963378482 13 Q9Y2R0,P53701,Q69YU5 3 +Protein insertion into membrane 0.6079952057933224 2.717719649458413 0.0065733508810592 1.0 0.467310963378482 30 P62072,Q15629,Q96A33,Q8WWC4,P46379,Q9NS69,Q9Y584,O43681 8 +Inorganic anion transport 0.6077077311511194 2.7025444847582496 0.0068810975941406 1.0 0.467310963378482 29 Q9Y277,Q9UHG3,Q15043,O15439,P30536,Q6N075,P08183,Q9H0H5,Q9UBX3,P51790,Q8TDW0,P45880,P21796,Q9C0H2,O43681 15 +Lipid localization 0.4608067052152004 2.6757155548226685 0.0074569903464181 1.0 0.467310963378482 72 Q9H2V7,P07602,P14174,Q96GC9,O43772,Q9H4L5,Q14108,Q07954,O15439,Q8WTV0,P23786,P30536,P08183,Q9Y255,O15118,O15260,Q86Y82,Q99720 18 +Organic acid transmembrane transport 0.5996110699716378 2.669969970968362 0.0075858030828652 1.0 0.467310963378482 31 P41440,O43772,P30825,Q9H2J7,P23786,P08183,Q9BQT8,P53985,Q8TDW0,Q9UBX3 10 +Plasma lipoprotein particle clearance 0.7863285285662996 2.655269378013294 0.0079245098782647 1.0 0.467310963378482 11 Q92945,P09601,Q8WTV0 3 +Peptide catabolic process 0.8117302845817238 2.627733255774569 0.0085955888590583 1.0 0.467310963378482 10 Q9UIQ6,P55786,P42892 3 +Lytic vacuole organization 0.6271912060223968 2.6210941450415453 0.0087648053882287 1.0 0.467310963378482 22 Q8N511,P54802,Q9P253,O75503,Q14108,P10253,P50897,O14773,P11117 9 +Calcium ion import 0.7530053120507658 2.6040938785328502 0.0092117520947223 1.0 0.467310963378482 12 O14936,Q8IYU8,Q8WWC4,O75844,Q9H4I9,P21796,Q9BPX6 7 +Circulatory system process 0.4569478295531057 2.58764611127315 0.0096634202920338 1.0 0.467310963378482 76 P41440,P30825,P42785,P09601,O15439,Q07954,P00813,P08183,P53985,P42892,Q9UIQ6,Q9HB40 12 +Vascular transport 0.6949504741690247 2.553317289456098 0.0106702244902916 1.0 0.467310963378482 14 P41440,P30825,Q07954,P08183,P53985 5 +Transition metal ion transport 0.719197439857605 2.551107558472065 0.0107381180853489 1.0 0.467310963378482 13 P35670,P50570,Q8TAD4,Q15043,O75027,O15173,Q9HD20 7 +Mitochondrial calcium ion transmembrane transport 0.7617823599957271 2.5321702030224102 0.0113358951359325 1.0 0.467310963378482 11 Q8WWC4,Q9H4I9,P21796,Q9BPX6 4 +Inner mitochondrial membrane organization 0.6138169637524344 2.530843955577731 0.0113788458709094 1.0 0.467310963378482 22 Q9NX63,P62072,Q16891,O75431,Q8WWC4,Q13505,Q9Y584,Q5HYI7 8 +Ph reduction 0.7381835469021669 2.5265989993332343 0.0115172922828654 1.0 0.467310963378482 12 Q93050,Q9Y487,Q8N511,P50897 4 +Ceramide metabolic process 0.6436618772115317 2.516846937929128 0.0118410257307834 1.0 0.467310963378482 19 Q99805,Q96G23,P06865,Q8NCC3,Q13510,O15121,P27544,P04062 8 +Cellular monovalent inorganic cation homeostasis 0.5870942842637182 2.513994783310485 0.0119372199624712 1.0 0.467310963378482 25 Q93050,Q9Y487,Q8N511,P50897 4 +Low density lipoprotein particle clearance 0.7872045522241083 2.5099870184807966 0.0120735599976418 1.0 0.467310963378482 10 Q92945,P09601,Q8WTV0 3 +Protein targeting to mitochondrion 0.5299717249815358 2.5091878293654397 0.0121009120584911 1.0 0.467310963378482 48 Q8N4H5,O95831,Q99595,P62072,P30536,Q9NS69,P55786,O60830 8 +Protein transmembrane transport 0.584348889731014 2.4941904344613417 0.012624479297149 1.0 0.467310963378482 25 O95831,Q99595,Q15629,Q9NS69,Q9Y584,O60830 6 +Regulation of plasma lipoprotein particle levels 0.679289302498258 2.4637386579402043 0.0137496324427881 1.0 0.4767265557488281 14 Q92945,P09601,Q8WTV0 3 +Regulation of response to osmotic stress 0.9369791409188636 2.4604583030316616 0.0138759694949326 1.0 0.4767265557488281 5 P08183 1 +Ceramide transport 0.9365461166501629 2.458743347228952 0.0139424250742932 1.0 0.4767265557488281 5 P07602 1 +Pigment metabolic process 0.5759419421317443 2.448783814710627 0.0143339452140858 1.0 0.4875066260577911 27 P09601,P22830,P00813,P30536,P30519 5 +Regulation of ph 0.6211863113272942 2.43716620415742 0.0148028738126126 1.0 0.4894157935788863 20 Q93050,Q9Y487,Q8N511,P50897 4 +Regulation of cellular ph 0.6211863113272942 2.43716620415742 0.0148028738126126 1.0 0.4894157935788863 20 Q93050,Q9Y487,Q8N511,P50897 4 +Organophosphate ester transport 0.5680461773605271 2.409439815049606 0.0159770309992717 1.0 0.4894157935788863 29 Q96GC9,Q7Z3C6,P41440,Q14108,O15439,Q8WTV0,P08183,Q9Y255 8 +Monovalent inorganic cation homeostasis 0.5679512573757605 2.398705729739301 0.0164531311086852 1.0 0.4894157935788863 28 Q93050,Q9Y487,Q8N511,P50897 4 +Regulation of lymphocyte apoptotic process 0.8132554735409621 2.397868612752297 0.0164907791879862 1.0 0.4894157935788863 8 P00813,P14174,Q96GD4 3 +Response to oxygen levels 0.468069072252 2.3869447356078513 0.0169890449146006 1.0 0.4894157935788863 59 Q8N511,Q9Y487,P09601,P00846,P00813,P30519,P55786 7 +Anion transmembrane transport 0.5277941847405573 2.365396741853007 0.0180107649906688 1.0 0.4894157935788863 44 Q9UHG3,P41440,P30825,O15439,P45880,P08183,Q9BQT8,P53985,Q9UBX3,Q8TDW0,P51790,P21796 12 +Blood vessel endothelial cell migration 0.5998252668695631 2.3632348683032105 0.0181161842596451 1.0 0.4894157935788863 21 P42785,Q8WTV0 2 +Regulation of glial cell proliferation 0.9108726655792798 2.3564492791814633 0.0184505871423779 1.0 0.4894157935788863 5 Q96G23 1 +Chromosome organization involved in meiotic cell cycle 0.6431747416110216 2.344842625732235 0.0190351121930567 1.0 0.4894157935788863 16 P46379,Q9BTX1,P46100 3 +Calcium import into the mitochondrion 0.8015544457439059 2.344619347610943 0.0190465136954069 1.0 0.4894157935788863 8 Q8WWC4,Q9H4I9,P21796,Q9BPX6 4 +Regulation of necrotic cell death 0.7037186605405128 2.343605775577116 0.0190983459705107 1.0 0.4894157935788863 12 P30536,P00403,Q13510 3 +Negative regulation of macroautophagy 0.750150048428615 2.3288674615403537 0.0198660881744914 1.0 0.4894157935788863 10 P09601 1 +Lysosomal protein catabolic process 0.8614261747641776 2.3217981448548923 0.0202438072020612 1.0 0.4894157935788863 6 Q07954,O14773,Q8N511 3 +Protein catabolic process in the vacuole 0.8614261747641776 2.3217981448548923 0.0202438072020612 1.0 0.4894157935788863 6 Q07954,O14773,Q8N511 3 +Porphyrin containing compound metabolic process 0.620207415569872 2.3084350829976983 0.020974949585135 1.0 0.491259441931697 18 P30536,P30519,P09601,P22830 4 +Mitochondrial calcium ion homeostasis 0.7173994988341063 2.3048890958326256 0.0211727854617036 1.0 0.4922412754053417 11 P51572,P08133,Q16891,Q8IYU8,Q8WWC4,Q9H4I9,Q96AQ8,Q9BPX6 8 +Membrane raft organization 0.7710546684747598 2.299930102973542 0.0214521803130856 1.0 0.4949174838545593 9 P41440,P50897 2 +Response to l glutamate 0.9676522897150348 2.290824508237 0.0219735655655521 1.0 0.5028235004745123 4 Q9UQB8 1 +Vacuole organization 0.4943204667844497 2.2900370130445324 0.0220191711186836 1.0 0.5028235004745123 51 Q96GC9,Q8N511,Q7Z3C6,O14773,P54802,O75503,Q14108,Q9P253,P10253,P50897,P56962,Q8TBX8,Q86Y82,P11117 14 +Membrane lipid biosynthetic process 0.5672666086922585 2.283772129964376 0.0223849264111613 1.0 0.5079551856386622 23 P04062,Q96G23,Q06136,Q13510,O15121,P27544,Q8NBX0 7 +Homologous chromosome segregation 0.7675892979278716 2.2834686415941556 0.0224027779715518 1.0 0.5079551856386622 9 P46379,Q9BTX1 2 +Protein localization to mitochondrion 0.4479508874989678 2.2811649002078216 0.0225386908970146 1.0 0.5092310586413842 61 Q8N4H5,Q99595,Q15070,P30536,Q9NS69,O14737,Q9Y584,O60830,Q10713,Q8N4Q1,P55786,O14925,O95831,P62072,Q9Y6C9,Q3ZCQ8,O96008,Q8WWC4,O00165,Q5JRX3 20 +Lipoprotein localization 0.8071508033344168 2.278711299255725 0.0226842326244431 1.0 0.5107147302841188 7 Q07954,O15260,A6NIH7 3 +Negative regulation of leukocyte migration 0.8470492626402618 2.2611224485683006 0.0237516756401257 1.0 0.5200639729744345 6 P00813,P09601 2 +Homologous chromosome pairing at meiosis 0.7801480392382647 2.2463252671497753 0.0246831812810537 1.0 0.5331417590810277 8 P46379,Q9BTX1 2 +Glial cell proliferation 0.8419050702508626 2.2393088249373205 0.0251358290742436 1.0 0.5332711916323911 6 P30536,Q96G23 2 +Response to food 0.8776805463194058 2.2223986399161224 0.0262563771784143 1.0 0.5335895635821486 5 P80303,P53985 2 +Regulation of toll like receptor signaling pathway 0.7542130482205402 2.2196292798105164 0.0264439430244978 1.0 0.5335895635821486 9 Q9NPR9 1 +Tetrapyrrole metabolic process 0.5781867681701891 2.2161793521448976 0.0266792213922617 1.0 0.5335895635821486 21 P30536,P09601,P30519,P22830 4 +Smad protein signal transduction 0.7260463130625208 2.2089440348441833 0.0271785338236791 1.0 0.5335895635821486 10 Q9UIQ6,Q07954,Q96PK6,P08670 4 +Regulation of b cell apoptotic process 0.8734375473266539 2.205116832575807 0.0274458971962769 1.0 0.5335895635821486 5 P00813,Q96GD4 2 +Response to increased oxygen levels 0.7249290751612165 2.2033450432577073 0.0275704384937303 1.0 0.5335895635821486 10 Q8N511,P00846 2 +Regulation of leukocyte apoptotic process 0.6776519064769138 2.202581269981904 0.027624275247635 1.0 0.5335895635821486 12 P00813,P14174,Q96GD4 3 +Regulation of lysosomal lumen ph 0.8706062397978489 2.19356654117689 0.0282665860011888 1.0 0.5395120922137351 5 Q8N511,P50897 2 +Mitochondrial respiratory chain complex assembly 0.5147274558770712 2.177825602233151 0.0294190230567379 1.0 0.5551793442453572 41 Q9Y2R0,O95831,Q9H061,Q69YU5,O43676,Q96CU9,O96000,Q6DKK2 8 +Organic hydroxy compound transport 0.5347356281591678 2.175993668482817 0.0295557339970431 1.0 0.5551793442453572 31 Q07954,O15439,Q8WTV0,P30536,P53985,O15118,Q86Y82 7 +Carbohydrate derivative catabolic process 0.5260192609832258 2.175054915462378 0.0296260014158853 1.0 0.5551793442453572 36 Q9NUJ1,Q13126,P54802,O60658,P16278,P06865,P06280,P04066,P00813,P35610,Q9BTY2,P15586,Q9H773,O60502,Q8TCJ2,P78549,P04062 17 +Sphingolipid biosynthetic process 0.6072311780214242 2.172976797127774 0.0297820636653358 1.0 0.5551793442453572 17 Q99805,Q96G23,Q06136,Q13510,O15121,P27544,P04062 7 +Cholesterol efflux 0.7640789943667158 2.1717926612171703 0.0298713054847377 1.0 0.5552242071785258 8 O15118,Q07954,Q8WTV0 3 +Regulation of membrane lipid distribution 0.742165094874071 2.16172350432209 0.0306394948093742 1.0 0.5554539261058453 9 Q96GC9,P08183,Q9Y255 3 +Regulation of response to extracellular stimulus 0.859240760243646 2.1470539535875046 0.0317889865343821 1.0 0.5554539261058453 5 P80303 1 +Toll like receptor signaling pathway 0.6464554355714112 2.1450252150812976 0.0319508309975693 1.0 0.5554539261058453 13 Q9NPR9,P51812,P41440 3 +Xenobiotic transport 0.8182603058383261 2.138346233712648 0.03248865275979 1.0 0.5554539261058453 6 P08183,O15439,P41440 3 +Regulation of b cell activation 0.601387035581539 2.1360938095178374 0.0326717682460502 1.0 0.5554539261058453 17 P14174,Q5RKV6,P00813,P02786,Q96IZ0 5 +Cellular response to chemical stress 0.4226630558805861 2.132967739613985 0.0329273727016816 1.0 0.5554539261058453 81 Q9NR28,P39210,P30536,Q8N0U8,Q8TDW0,Q969S3,Q9BPX6,O60658,Q9UL15,P09601,O43813,O75569,O95831,P16615,Q96IZ0,Q7Z2K6,P23246,Q15233,Q99720,P04062 20 +Rna stabilization 0.5343281940309967 2.131076009630002 0.0330828807618139 1.0 0.5554539261058453 26 Q92804,P35637,Q14011,O60506,Q08J23,P67809 6 +Regulation of pattern recognition receptor signaling pathway 0.5917168809698071 2.1260636149345435 0.0334979630077851 1.0 0.5554539261058453 18 Q9NPR9,O43657,P41440 3 +Gland development 0.4128127169930649 2.1216135895510013 0.0338702002575577 1.0 0.5554539261058453 65 P35670,P07602,O94788,P09601,P00813,P30536,P11717,O75844,Q15418,P25325,P00403,Q13505,Q96JB5,P15531 14 +Positive regulation of b cell activation 0.6816541519029108 2.117384597316413 0.0342272203449645 1.0 0.5554539261058453 11 P00813,P14174,P02786,Q5RKV6 4 +Carboxylic acid transport 0.5198910693090961 2.109503666132694 0.0349011299036605 1.0 0.5634120637016959 35 P07602,P14174,P41440,P30825,Q9H2J7,O15439,Q9BQT8,P53985,Q8TDW0,Q9UBX3 10 +Regulation of neuron projection development 0.408070845009537 2.0947668808488995 0.036191720575649 1.0 0.5685745979378374 69 Q9NR77,O14976,Q9NQX7,Q96G23,Q14108,Q9UL15,P07196,Q9UQB8,P08670,O15031 10 +Positive regulation of necrotic cell death 0.8049929573719693 2.081195036529945 0.037416057689336 1.0 0.5699879965941225 6 P30536,P00403 2 +Cellular response to exogenous dsrna 0.7444280502950149 2.0797780905686976 0.0375458915785564 1.0 0.5699879965941225 8 Q5KU26,P41440 2 +Amyloid precursor protein metabolic process 0.5487338260124712 2.0785166474434593 0.0376617992175842 1.0 0.5699879965941225 22 Q9NQX7,P62942,Q9NQC3,Q9NY61,P35610,Q12959,P27695,Q96IZ0,Q96P70,P49755,Q15392,O95197,Q13464,Q13492 14 +Negative regulation of neuron projection development 0.5756793163862493 2.076020098109368 0.0378920922041852 1.0 0.5699879965941225 19 Q9NR77,Q9NQX7,Q96G23,Q9UL15,P08670 5 +Iron ion homeostasis 0.5910223048469813 2.0703270235371325 0.0384217306109848 1.0 0.5711046143304149 17 Q8N511,O75027,Q9Y487,P09601,P30519 5 +Respiratory chain complex iii assembly 0.80228591382205 2.0694901882592927 0.0385001111112459 1.0 0.5711046143304149 6 Q69YU5 1 +Transition metal ion homeostasis 0.526174013259213 2.0692784508269857 0.0385199646030802 1.0 0.5711046143304149 26 P35670,Q8N511,Q8TAD4,Q9Y487,P09601,O75027,P30519 7 +Deoxyribonucleoside triphosphate metabolic process 0.7396974814710525 2.0574855029445365 0.0396395479990294 1.0 0.5751168901426106 8 P00813,P55263 2 +Modified amino acid transport 0.8374463140570161 2.057206824202707 0.0396663354008275 1.0 0.5751168901426106 5 P41440,O43772 2 +Protein insertion into mitochondrial inner membrane 0.7571986374985138 2.0532510014190457 0.0400482403304554 1.0 0.5780326155145188 7 P62072 1 +Carbohydrate derivative transport 0.5717689266353606 2.0500242153969586 0.0403620678338638 1.0 0.5808699041929128 19 P07602,P41440,Q8WTV0 3 +Negative regulation of cell population proliferation 0.4238366477903181 2.049364249226125 0.0404265103793941 1.0 0.5808699041929128 90 Q9NR77,P02545,P25705,Q96G23,O14936,P30536,P98175,O14737,P09601,Q96DY7,Q92796,Q9UHI6,Q99627,Q15392,O75569,Q32P28,O94788,Q9Y3B8,Q96IZ0,Q13641,P15531,P57105,P50402,Q12959 24 +Necrotic cell death 0.5938335742778102 2.0409628578440437 0.0412545190607041 1.0 0.5865535123355726 16 P30536,P00403,Q13510 3 +Tetrapyrrole catabolic process 0.9024891711184582 2.0382078396315384 0.0415291518192086 1.0 0.5865535123355726 4 P30519 1 +Meiosis i cell cycle process 0.5930261014713292 2.0359073674656063 0.04175965788368 1.0 0.5865535123355726 16 P46379,Q9BTX1,P46100 3 +Regulation of systemic arterial blood pressure 0.7935722237207563 2.031713258815018 0.0421826928627806 1.0 0.5865535123355726 6 P42785 1 +Negative regulation of autophagy 0.5211036174223838 2.0260637501036185 0.042758252227772 1.0 0.5865535123355726 25 P09601,P30536,P85037,P10619,O15118 5 +Protein maturation 0.4040590599394389 2.0182289496867645 0.0435674224447826 1.0 0.5865535123355726 65 Q8TAD4,Q9NRN7,P41227,P49366,P42892,Q10713,Q8N4Q1,O75844,Q9UG56,Q15392,O75976,O75503,Q6IQ49,Q86UY6,Q5VZE5,Q9BU89,P35670,Q96F07,P62942,Q5JRX3,Q92896 21 +Ceramide biosynthetic process 0.6621009755841933 2.013139621054313 0.0440999430464206 1.0 0.5865535123355726 11 Q96G23,O15121,P27544,Q13510 4 +Response to oxidative stress 0.4243101342866749 2.012701591033387 0.0441460319140427 1.0 0.5865535123355726 94 P04062,Q9NR28,P39210,P30519,Q8N0U8,Q969S3,O60658,Q9UL15,P09601,Q15165,Q15392,O43813,O75569,O95831,O43169,P16615,P00374,Q96IZ0,Q7Z2K6,P23246,Q15233,P03915,P28074,Q99720 24 +Reticulophagy 0.8945830403870347 2.007121863375252 0.0447366887874771 1.0 0.5906134363714721 4 Q9Y6I9 1 +Protein import into mitochondrial matrix 0.7275252442808996 1.9998731123962032 0.0455139672037629 1.0 0.5906134363714721 8 Q99595 1 +Membrane lipid catabolic process 0.6406848713678249 1.998716765085014 0.0456390080100865 1.0 0.5906134363714721 12 P06865,P06280,P50897,P04066,Q13510,P04062 6 +Aminoglycan metabolic process 0.5999829570916037 1.9956549053667991 0.0459714987287829 1.0 0.5906134363714721 14 P54802,P16278,P06865,O43505,P04066,P15586,Q7LGA3 7 +Regulation of endothelial cell migration 0.5155553267981037 1.9935519115341156 0.0462010450996444 1.0 0.5906134363714721 27 P25705,P57105,P42785,P09601,Q8WTV0 5 +Lysosomal lumen acidification 0.8897348484972667 1.9880140898574212 0.0468101317003659 1.0 0.5906134363714721 4 Q8N511,P50897 2 +Intracellular protein transmembrane transport 0.544907379257981 1.9855134784611457 0.0470873720415465 1.0 0.5906134363714721 21 O95831,O60830,Q99595,Q15629 4 +Nuclear pore organization 0.6383069167221375 1.9854493737544088 0.0470944973868627 1.0 0.5906134363714721 12 P12270,Q8N1F7,P57740,Q8NFH5,Q7Z3B4,Q9BTX1 6 +Sensory perception of light stimulus 0.5914225007356081 1.982873826301333 0.0473815249429003 1.0 0.5906134363714721 15 Q9H6K4,Q6P4Q7,O43924,P50897 4 +Chloride transport 0.5977822820786796 1.9823235446489524 0.0474430405030206 1.0 0.5906134363714721 14 Q9UHG3,P08183,Q9C0H2 3 +Liposaccharide metabolic process 0.5843905235790003 1.9816778060496547 0.0475153127456828 1.0 0.5906134363714721 16 Q99805,P16278,P06865,P06280,P04066,Q8NBX0,P04062 7 +Sterol transport 0.5254325171415184 1.980148883144886 0.0476868017029492 1.0 0.5906134363714721 23 Q07954,Q8WTV0,P30536,O15118,Q86Y82 5 +Bone morphogenesis 0.7408649115489334 1.9782809181050296 0.0478970245539727 1.0 0.5906134363714721 7 Q92896,P08133,Q7Z3C6,O75844 4 +Protein targeting 0.4322275685504724 1.9644718219841824 0.0494754009136479 1.0 0.5906134363714721 108 Q8N4H5,Q99595,P30536,P46379,O14737,Q9NS69,Q9Y2T2,Q7Z3B4,Q9Y584,O60830,Q10713,Q9Y5M8,P40855,Q8N4Q1,Q14108,O75381,P43307,P55786,O14925,O95831,O60725,P62072,P56589,Q3ZCQ8,P20645,Q99523,Q15629,P57105,O96008,O00165,Q5JRX3,O43681 32 +Positive regulation of protein deacetylation 0.7774890119693525 1.9615886259808275 0.049810397548583 1.0 0.5906134363714721 6 O43823,P49354 2 +Regulation of tube size 0.6999379258277119 1.955751927259499 0.050494384387284 1.0 0.5906134363714721 9 P42892 1 +Neutral lipid biosynthetic process 0.8129416900102796 1.955176745173533 0.0505622123787405 1.0 0.5906134363714721 5 Q8WTV0 1 +Negative regulation of b cell apoptotic process 0.881369228664242 1.9549634344550584 0.0505873863103607 1.0 0.5906134363714721 4 P00813,Q96GD4 2 +Negative regulation of lymphocyte apoptotic process 0.8121631858888692 1.9519180784169616 0.0509479315498617 1.0 0.5906134363714721 5 P00813,Q96GD4 2 +Negative regulation of leukocyte apoptotic process 0.8121631858888692 1.9519180784169616 0.0509479315498617 1.0 0.5906134363714721 5 P00813,Q96GD4 2 +Negative regulation of mrna splicing via spliceosome 0.586161706393087 1.9503315754188233 0.0511366115383533 1.0 0.5906134363714721 15 Q13242,P61978,P38159,P98175,O75494,P22626 6 +Toll like receptor 3 signaling pathway 0.8791703998418751 1.9462597248615197 0.0516235488864458 1.0 0.5906134363714721 4 P41440 1 +Glycoside catabolic process 0.7732555007728056 1.9430450982100709 0.0520107095844188 1.0 0.5906134363714721 6 Q9BTY2,Q9NUJ1,P06280,P04062 4 +Respiratory chain complex iv assembly 0.7331551269363032 1.9426839762209749 0.0520543534693227 1.0 0.5906134363714721 7 Q9Y2R0,Q15070 2 +Positive regulation of mitochondrial translation 0.7327499388843483 1.9408094893633971 0.052281389581835 1.0 0.5906134363714721 7 Q567V2,Q9Y2R0 2 +Lipid translocation 0.7145984143194986 1.9382963989124504 0.0525870715044327 1.0 0.5919748859143363 8 Q96GC9,P08183 2 +Regulation of leukocyte proliferation 0.5087705808324718 1.9321514679600067 0.0533408133395174 1.0 0.5983529131453941 25 P14174,P30825,P04439,P00813,P49366,Q12959,P02786,Q96IZ0 8 +Response to nitric oxide 0.7274232937707557 1.916133244096471 0.0553481377568296 1.0 0.5987642454259602 7 P50570,Q14103,O95831,P25705 4 +Cellular response to reactive nitrogen species 0.7274232937707557 1.916133244096471 0.0553481377568296 1.0 0.5987642454259602 7 P50570,Q14103,O95831,P25705 4 +Protein insertion into er membrane 0.6042745437575717 1.900945396207079 0.0573091651257942 1.0 0.5987642454259602 13 P46379,O43681,Q15629 3 +Organic acid transport 0.469716222519623 1.9008787264971083 0.0573178991483862 1.0 0.5987642454259602 46 P14174,P41440,O43772,P30825,Q9H2J7,O15439,P23786,P08183,Q9BQT8,P53985,Q8TDW0,Q9UBX3 12 +Negative regulation of cell projection organization 0.5016613549743109 1.8980664801804257 0.0576873250802596 1.0 0.598786942472695 29 Q9NR77,O14976,Q9NQX7,Q96G23,Q9UL15,P08670 6 +Negative regulation of blood pressure 0.8664851775686511 1.895914226804445 0.0579713873865364 1.0 0.6007602122358408 4 P42785 1 +Metal ion homeostasis 0.402663382190784 1.8930281470029409 0.0583541264257134 1.0 0.6037480329547119 81 O43819,Q8TAD4,Q14344,Q15043,P08133,Q16891,Q13586,Q8IYU8,Q96A33,P30519,P07686,P02786,Q9BPX6,Q8N511,Q15904,Q9Y487,P09601,Q8NE01,Q96TC7,O75027,Q8NEW0,P16615,Q9HD20,P35670,P62942,O60826,Q6P4Q7,Q8WWC4,Q9H4I9 29 +Intraciliary transport 0.7609573599354224 1.8889793529551744 0.0588945953631236 1.0 0.607374262502924 6 Q7Z4L5,O43805 2 +Skeletal system morphogenesis 0.5754023521076859 1.8834489732629165 0.0596395488070153 1.0 0.6117560154164017 15 Q7Z3C6,P08133,O75844,Q92896,P16435,O75569 6 +Negative regulation of mrna processing 0.5303617962594134 1.883022241473724 0.0596973538590768 1.0 0.6117560154164017 21 Q13242,O75150,Q16629,P61978,Q5VTR2,P38159,P98175,O75494,P22626 9 +Protein transmembrane import into intracellular organelle 0.6012123332891378 1.8829866121995789 0.0597021822990044 1.0 0.6117560154164017 13 O95831,O60830,Q99595 3 +Regulation of protein deacetylation 0.6846135508673757 1.8798626748790952 0.0601267959853768 1.0 0.6149664160141882 9 O43823,Q9ULX6,P49354 3 +Regulation of amyloid beta clearance 0.8614613880856921 1.8759138943887368 0.0606671044231887 1.0 0.6167018532303166 4 Q16850 1 +Cellular response to dsrna 0.6583178635050634 1.8631298685610675 0.062443996856542 1.0 0.630194177005433 10 Q5KU26,P41440 2 +Iron ion transport 0.6978504252028487 1.857926037190178 0.0631795183249241 1.0 0.630194177005433 8 P50570,Q15043,O75027,O15173 4 +Guanine nucleotide transmembrane transport 0.8566569178093939 1.8567545331898252 0.0633460850520433 1.0 0.630194177005433 4 O15439,P41440 2 +Guanine nucleotide transport 0.8566569178093939 1.8567545331898252 0.0633460850520433 1.0 0.630194177005433 4 O15439,P41440 2 +Polyadenylation dependent snorna 3 end processing 0.7532751547001554 1.8550592053565784 0.0635877724626352 1.0 0.630194177005433 6 Q9NQT5,Q5RKV6 2 +Pattern recognition receptor signaling pathway 0.4970229530219277 1.8550321668835736 0.0635916332539894 1.0 0.630194177005433 28 Q5KU26,P41440,Q9NPR9,P51812,O43657 5 +Negative regulation of g protein coupled receptor signaling pathway 0.7532688192985401 1.8550311857804351 0.0635917733481787 1.0 0.630194177005433 6 P00813 1 +Antigen processing and presentation of peptide antigen 0.6145667686910832 1.852002434876998 0.0640254732678389 1.0 0.630194177005433 12 P50570,P10321,Q9UIQ6,Q03519 4 +Myotube differentiation 0.5763994775425115 1.8518593951652955 0.0640460159933458 1.0 0.630194177005433 14 Q8IV08 1 +Glycosphingolipid metabolic process 0.6789858379862352 1.8518443732420924 0.0640481736907312 1.0 0.630194177005433 9 Q99805,P16278,P06865,P06280,P04062 5 +Cellular transition metal ion homeostasis 0.525155688312447 1.8460998535110305 0.0648777081276539 1.0 0.630194177005433 21 P35670,Q8N511,Q8TAD4,Q15043,Q15904,Q9Y487,P09601,O75027,O60826,Q8NEW0,P02786 11 +B cell activation involved in immune response 0.5629712328233509 1.845902546800036 0.0649063568217944 1.0 0.630194177005433 16 P00813,Q9UQ84,P02786,Q5RKV6 4 +Pigment biosynthetic process 0.5162728517866647 1.8448509742081896 0.0650592199743342 1.0 0.630194177005433 22 O75027,P22830,P00813,P30536,P36551,O00264,P22234,P50336 8 +Ceramide catabolic process 0.7096584621452645 1.8333839858533585 0.0667454874237669 1.0 0.6369711143097999 7 P06865,P06280,P04062,Q13510 4 +Membrane protein proteolysis 0.6111141254609773 1.8324469125313376 0.0668848641799859 1.0 0.6373499576256785 12 P35579,Q16740,O43847,P38159,Q13464 5 +Amyloid beta clearance 0.6922371754006311 1.8308424517235131 0.0671240619771869 1.0 0.6386774587531742 8 Q16850 1 +Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.6274959213120734 1.8258082863016187 0.0678791447150335 1.0 0.6420403125856871 11 P61978,P46379,P14174 3 +B cell homeostasis 0.7820195968974148 1.824953164755453 0.0680080973208305 1.0 0.6423098585958504 5 P00813 1 +Mitochondrial cytochrome c oxidase assembly 0.7448736085465207 1.817835668330394 0.0690892532424942 1.0 0.6486670838828976 6 Q9Y2R0,Q15070 2 +Negative regulation of neuron apoptotic process 0.5208126343608197 1.815204133192632 0.069492544769883 1.0 0.6486670838828976 21 P04062,P09601,P07196,P50897,Q01105,P48507,Q13464,Q15233 8 +Appendage morphogenesis 0.6714736872112965 1.8143216884384603 0.069628214393993 1.0 0.6486670838828976 9 O94788,P42892 2 +Intrinsic apoptotic signaling pathway in response to dna damage 0.5120283153171878 1.8139190642219736 0.0696901872172608 1.0 0.6486670838828976 22 P14174,Q9Y3B8,P61978,P09601,Q8N163,P46379,Q96RU2 7 +Negative regulation of mrna metabolic process 0.4651892176922675 1.809622601103221 0.0703543325901576 1.0 0.6528963752996634 44 Q14103,Q13242,O75150,Q92804,P35637,P61978,Q14011,O60506,P38159,P98175,Q99729,O75494,P22626,P67809 14 +Sulfur compound transport 0.623973745660698 1.8065437485243432 0.0708334470033469 1.0 0.655351922441891 11 O15439,Q9H0H5,Q9UBX3,Q8TDW0,Q70HW3 5 +Vitamin transmembrane transport 0.7422223209901653 1.8060617903576195 0.0709086883679595 1.0 0.655351922441891 6 Q8WTV0,P41440 2 +Regulation of dna templated transcription in response to stress 0.6695716687673182 1.8047992514482505 0.0711061015877871 1.0 0.656064088820074 9 P09601,Q15418 2 +Positive regulation of endocytosis 0.5181011950913025 1.795872579233628 0.0725147843516249 1.0 0.6563355128523494 21 P41440,P61978,Q07954,P50897,O00291 5 +Sodium ion transmembrane transport 0.5088173710143448 1.7904635680984098 0.0733794190021919 1.0 0.6563355128523494 22 P50570,Q9H2J7,Q6P4Q7,Q12959,O43707,Q9H4A3,Q9Y6M7,Q14BN4,P46939 9 +Intracellular lipid transport 0.6035358678184971 1.7893960930110888 0.073551048103422 1.0 0.6563355128523494 12 O15118,O43772 2 +Glycosyl compound biosynthetic process 0.700201400361324 1.7890547592735009 0.0736059971069504 1.0 0.6563355128523494 7 P00813,Q13126 2 +Nucleobase containing small molecule biosynthetic process 0.700201400361324 1.7890547592735009 0.0736059971069504 1.0 0.6563355128523494 7 P00813,Q13126 2 +Cellular ion homeostasis 0.3984780323723798 1.7868997618029403 0.0739536910292486 1.0 0.6563355128523494 86 O43819,Q8TAD4,Q93050,Q14344,Q15043,P08133,Q16891,Q13586,Q8IYU8,Q96A33,P02786,P07686,P51790,Q9BPX6,Q8N511,Q15904,Q9Y487,P09601,P50897,Q96TC7,O75503,O75027,Q8NEW0,P16615,Q9HD20,P35670,P62942,O60826,Q8WWC4,Q9H4I9,Q9Y6M7 31 +Meiotic chromosome segregation 0.5324327890751879 1.7847939144556693 0.0742947508170241 1.0 0.6563355128523494 19 P46379,Q9BTX1 2 +Cellular response to increased oxygen levels 0.6981652332925604 1.7794856653735958 0.075160172953447 1.0 0.6563355128523494 7 Q8N511 1 +Regulation of mrna export from nucleus 0.7711528921643711 1.778816518406324 0.0752698481349414 1.0 0.6563355128523494 5 Q9ULX6,Q08J23 2 +Regulation of rna export from nucleus 0.6415149719309429 1.7753783981981188 0.0758354283717734 1.0 0.6563355128523494 10 P12270,Q9H7Z3,Q9ULX6,Q08J23 4 +Cellular iron ion homeostasis 0.5820573351833983 1.769943426139404 0.0767365656318075 1.0 0.6563355128523494 13 Q8N511,Q15043,O75027,Q9Y487,P09601 5 +Glycolipid catabolic process 0.6959540502126779 1.76908426619362 0.0768798131730932 1.0 0.6563355128523494 7 P04062,P06865,P06280,P04066 4 +Ribonucleoprotein complex localization 0.6958171505378732 1.7684399561702775 0.0769873817957462 1.0 0.6563355128523494 7 P12270,Q9ULX6,Q8WWY3,Q08J23 4 +U4 snrna 3 end processing 0.7334956409618855 1.7672176192214728 0.0771917900633354 1.0 0.6563355128523494 6 Q9NQT5,Q5RKV6 2 +Peripheral nervous system axon regeneration 0.8339755726801326 1.7658942136050602 0.0774135981657901 1.0 0.656824521201747 4 Q96G23,P07196 2 +Receptor recycling 0.6946393442679389 1.7628950771117056 0.0779181874994079 1.0 0.656824521201747 7 P42892 1 +Intrinsic apoptotic signaling pathway 0.3818514039505217 1.7533061144878062 0.0795494765255051 1.0 0.6625086328614759 71 P14174,O95831,Q9Y3B8,Q9UL15,P61978,Q9NR28,P09601,Q8N163,P46379,Q96RU2,P23246,P45880,Q15233,Q969S3 14 +Positive regulation of leukocyte proliferation 0.5485104045059135 1.7532497638527786 0.0795591444184671 1.0 0.6625086328614759 16 P14174,P30825,P04439,P00813,P49366,P02786 6 +Receptor localization to synapse 0.5791903127472822 1.7529213875432432 0.0796155018647239 1.0 0.6625086328614759 13 P57105,Q92796,Q16643,Q12959,P33176,Q14168,O15400 7 +Deoxyribonucleoside monophosphate metabolic process 0.6920141673656747 1.7505259526877948 0.0800275999100357 1.0 0.6636789543771314 7 P00813 1 +Regulation of b cell proliferation 0.6914327083429492 1.7477843574456149 0.0805013749686915 1.0 0.6650204025191395 7 P00813,P14174,Q96IZ0 3 +Mitochondrial membrane organization 0.447480492331952 1.7468081942966551 0.0806706147145683 1.0 0.6655585941741293 48 Q9NX63,Q8IWA4,P62072,Q16891,O75431,Q15070,Q8WWC4,O14737,Q9NS69,Q13505,Q9Y584,Q3ZCQ8,P45880,Q5HYI7 14 +Regulation of mitochondrial gene expression 0.6348713574867116 1.7404794313634342 0.0817748686851511 1.0 0.6713450620699521 10 Q567V2,Q9Y2R0 2 +Regulation of translation in response to stress 0.6347197315075029 1.739681623218798 0.0819149379051098 1.0 0.6713450620699521 10 P51812,Q15418,Q13217 3 +Negative regulation of gliogenesis 0.7618533637214576 1.739186553208227 0.0820019539375402 1.0 0.6713450620699521 5 Q96G23 1 +Regulation of nucleobase containing compound transport 0.6107004903534948 1.7336304832314295 0.08298366817634 1.0 0.6745365871368294 11 P12270,Q9H7Z3,Q9ULX6,Q08J23 4 +Regulation of gliogenesis 0.5935272076013232 1.732274205929604 0.0832247522760467 1.0 0.6745365871368294 12 Q96G23 1 +Synaptonemal complex organization 0.7595637086906797 1.7294088962157084 0.0837359389418004 1.0 0.6768743281844146 5 P46379 1 +Secondary alcohol metabolic process 0.4734510161725315 1.7254897417874335 0.0844392508989986 1.0 0.6798747637352721 35 P16435,P34913,P37268,Q14739,Q8WTV0,Q15800,P48735,P35610,O15118,Q15392,P48449,O75874,P04062,Q16850 14 +Regulation of phospholipase a2 activity 0.823517800054594 1.7237822277377517 0.0847471641426591 1.0 0.6798747637352721 4 P50897 1 +Proton transporting two sector atpase complex assembly 0.7579821440850054 1.7226504376220944 0.0849517581000351 1.0 0.6798747637352721 5 Q15070,Q8N511 2 +Regulation of t cell proliferation 0.5305211772953563 1.7225805655571893 0.0849644019697508 1.0 0.6798747637352721 18 P30825,P04439,P49366,Q12959,P02786,Q96IZ0 6 +Nls bearing protein import into nucleus 0.6313655463539994 1.7220181061960618 0.0850662386195173 1.0 0.6798747637352721 10 Q8NFH5,Q7Z3B4 2 +Astrocyte development 0.8212933779519553 1.7148078330254266 0.0863804649478328 1.0 0.6804021113173779 4 P08670 1 +Lysosomal transport 0.4717904974400656 1.7115289370590894 0.0869835140393069 1.0 0.6811372915113535 35 P20645,P07602,O14976,Q9P253,Q14108,Q07954,P11717,O15118 8 +Sno s rna metabolic process 0.6063730917734338 1.7097536497586192 0.0873114373037637 1.0 0.6811372915113535 11 Q9NQT5,Q13868,Q5RKV6 3 +Cellular hormone metabolic process 0.5207772642837257 1.7049611936093645 0.0882016621992511 1.0 0.6839082470896831 19 P30536,Q9HB40,O94788,P42892 4 +Regulation of rna splicing 0.3925762997302569 1.7038625142872097 0.0884067755958768 1.0 0.6843497859080345 87 P51114,P52597,Q13243,P62995,Q8WVV9,Q5BKZ1,P98175,Q96EP5,P08621,P31943,Q9UHX1,Q13242,Q9BWF3,P35637,Q9Y5S9,Q96QD8,Q96E39,P98179,Q07021,O75525,P55795,Q9UKA9,Q92841,Q96T37,Q9Y2W1,Q96PU8,P38159,P31942,Q07955,Q07666,P22626,Q8IY67,O75312,Q16629,P61978,Q14011,P17844,O75494 38 +Terpenoid metabolic process 0.5203785928603035 1.702221113154252 0.0887139263419047 1.0 0.6855393382970797 19 P37268,O94788,Q07954,Q6NUM9,Q9HB40 5 +Receptor mediated endocytosis 0.4303780693712526 1.7018959329184054 0.088774878340629 1.0 0.6855393382970797 52 P20645,Q5VW38,O14976,P41440,P61978,Q14108,Q07954,P50897,P11717,O00291 10 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.5698681476149305 1.6973962982503483 0.0896217619493047 1.0 0.6877155224335806 13 P46379 1 +Protein quality control for misfolded or incompletely synthesized proteins 0.6039574354559267 1.6964030260209368 0.0898095810497403 1.0 0.6877155224335806 11 P46379 1 +Hormone metabolic process 0.4753830288361955 1.6949349054578753 0.0900877699911828 1.0 0.6890205757459605 30 O94788,Q8TAD4,P30536,O75844,P42892,Q9HB40 6 +Aminoglycan catabolic process 0.750797287966207 1.6919009147741384 0.0906648675570407 1.0 0.6891352986057356 5 P54802,P16278,P04066 3 +Glycosaminoglycan catabolic process 0.750797287966207 1.6919009147741384 0.0906648675570407 1.0 0.6891352986057356 5 P54802,P16278,P04066 3 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.8155796527235142 1.6917294242205043 0.0906975754868397 1.0 0.6891352986057356 4 O43823 1 +B cell apoptotic process 0.6794736081186079 1.691245081323182 0.0907900041579408 1.0 0.6891352986057356 7 P00813,Q96GD4 2 +Regulation of t cell apoptotic process 0.8152332788865757 1.6903291714310826 0.0909649971884956 1.0 0.6891352986057356 4 P00813 1 +Cellular metabolic compound salvage 0.6245417947747596 1.68599679766956 0.0917964161609834 1.0 0.6898459555422998 10 P00813,Q13126 2 +Cell cell adhesion mediated by integrin 0.8135508251027506 1.6835257368727825 0.0922733613902937 1.0 0.6898459555422998 4 P00813,Q9H4A3 2 +Detection of biotic stimulus 0.7484229386382267 1.6817226984038334 0.0926226244271424 1.0 0.6898459555422998 5 Q8WTV0 1 +Purine ribonucleoside metabolic process 0.661297633303472 1.680290358292995 0.0929008360774714 1.0 0.6898459555422998 8 P00813,Q13126,P55263 3 +Ribonucleoside metabolic process 0.661297633303472 1.680290358292995 0.0929008360774714 1.0 0.6898459555422998 8 P00813,Q13126,P55263 3 +Receptor clustering 0.5485160234687961 1.6793019897516808 0.0930932034176235 1.0 0.6898459555422998 14 P49354,P57105,Q92796,Q14168,O43805 5 +Small rna loading onto risc 0.7463106092743357 1.6726609035711957 0.0943940699402161 1.0 0.6898459555422998 5 Q5KU26 1 +Organic hydroxy compound catabolic process 0.5995995596861803 1.672279024155244 0.0944693139022749 1.0 0.6898459555422998 11 P21964,Q8WTV0 2 +Protein import 0.390704524010935 1.669987827725656 0.0949217719263111 1.0 0.6898459555422998 88 Q99595,P02545,Q9NPF5,Q7Z4Q2,Q99567,P55735,O14737,Q9NS69,Q7Z3B4,O60830,P12270,P40855,Q8N4Q1,O75381,O00459,Q92973,Q8NFH5,Q14978,O14925,O95831,P57740,P56589,P52292,Q3ZCQ8,Q8N1F7,P06493,O96008,Q96P70 28 +Vitamin transport 0.6747790739234906 1.6689730664161753 0.0951227176706996 1.0 0.6898459555422998 7 Q8WTV0 1 +Phosphatidylcholine metabolic process 0.6579651411502565 1.6639509758701614 0.0961222267626085 1.0 0.6898459555422998 8 Q8WTV0,Q8NCC3 2 +Deoxyribose phosphate metabolic process 0.5814756320275061 1.6631071042547962 0.0962909980779243 1.0 0.6898459555422998 12 P00813,P55263,Q9H773 3 +Rna surveillance 0.6198339546637122 1.6610785074761536 0.0966976803787158 1.0 0.6898459555422998 10 Q9NQT5,Q5RKV6 2 +Positive regulation of blood circulation 0.8079584312265906 1.6608886880665388 0.0967358045515456 1.0 0.6898459555422998 4 P00813 1 +Sterol homeostasis 0.6191919803376846 1.6576764429483828 0.0973827910785158 1.0 0.6898459555422998 10 Q8WTV0 1 +Negative regulation of secretion 0.498731983097177 1.6568541259751697 0.0975489709089616 1.0 0.6898459555422998 21 P00813,Q16850 2 +Antigen processing and presentation of endogenous peptide antigen 0.6720515696315561 1.6560135227252848 0.0977190803465042 1.0 0.6898459555422998 7 P10321,Q03519 2 +Antigen processing and presentation of endogenous antigen 0.6720515696315561 1.6560135227252848 0.0977190803465042 1.0 0.6898459555422998 7 P10321,Q03519 2 +Regulation of heterotypic cell cell adhesion 0.804661879150778 1.647528751842776 0.0994494114550754 1.0 0.6914380464394474 4 P41440 1 +Regulation of receptor recycling 0.7060811335812982 1.6443221949787323 0.1001096670730241 1.0 0.6914380464394474 6 P42892 1 +Body fluid secretion 0.5426165972313355 1.6424625895868532 0.1004941730002357 1.0 0.6914380464394474 14 P35670,P00813,P00403,Q13505,Q9H4A3,P15531 6 +Purine containing compound salvage 0.6690940762496467 1.6419451598543835 0.1006013697165171 1.0 0.6914380464394474 7 P00813,Q13126 2 +Respiratory system development 0.4712893039751936 1.6406965674991087 0.1008604178138872 1.0 0.6914380464394474 24 P00813,P46379 2 +Monocarboxylic acid transport 0.653089601012763 1.6400046950967857 0.1010041907371568 1.0 0.6914380464394474 8 O15439,P53985 2 +Protein ufmylation 0.8027939674565479 1.6399534958455748 0.1010148365625973 1.0 0.6914380464394474 4 Q96HY6 1 +Organic cation transport 0.7044642255037914 1.6370346036225074 0.1016232394568437 1.0 0.6914380464394474 6 O43772 1 +Regulation of lipoprotein particle clearance 0.7042884859695531 1.6362422732788495 0.1017888923191083 1.0 0.6914380464394474 6 Q92945 1 +Embryonic appendage morphogenesis 0.6672129444218088 1.6329883034628403 0.1024714566813584 1.0 0.6914380464394474 7 P42892 1 +Glycosyl compound catabolic process 0.6139319755701135 1.6297648882993951 0.1031511972808711 1.0 0.6914380464394474 10 Q9NUJ1,Q13126,P06280,P00813,Q9BTY2,P04062 6 +Cell death in response to oxidative stress 0.4691224216990565 1.6297033915316868 0.1031642002351005 1.0 0.6914380464394474 27 Q99720,O60658,Q9UL15,Q9NR28,Q96IZ0,P23246,O43813,Q15233,Q969S3 9 +Positive regulation of cell cycle checkpoint 0.7356579975744068 1.626866686187889 0.1037654146801685 1.0 0.6947393313769609 5 P12270,Q8N163 2 +Sphingoid metabolic process 0.734383816985922 1.6213787909196111 0.104936426494993 1.0 0.6974741881595874 5 Q06136,Q13510 2 +Purine nucleoside biosynthetic process 0.7009246652028337 1.6210668817217992 0.1050032957318891 1.0 0.6974741881595874 6 P00813,Q13126 2 +Negative regulation of cysteine type endopeptidase activity 0.5012910275044246 1.6204375407330145 0.105138321148438 1.0 0.6974741881595874 20 Q9Y3B8,P51812,Q15418,Q96K76,Q15392,P16435 6 +Cartilage development 0.5563829562603775 1.6166119117857447 0.1059620790299877 1.0 0.6974741881595874 13 Q15043,P08133,O75844,Q96HY6,Q92896 5 +Nuclear pore complex assembly 0.6318464618652488 1.614170225730515 0.106490508308334 1.0 0.6974741881595874 9 P12270,Q8N1F7,P57740,Q9BTX1 4 +Signaling receptor ligand precursor processing 0.7959551147474793 1.6121876749003543 0.1069211064802593 1.0 0.6983182378291911 4 P42892 1 +Plasma membrane phospholipid scrambling 0.79575371688752 1.6113692726930295 0.1070992603617186 1.0 0.6985950837592381 4 Q96GC9 1 +Tetrapyrrole biosynthetic process 0.5540583292004551 1.6026329789134042 0.1090157082561711 1.0 0.7006901876619157 13 O75027,P22830,P30536,P36551,O00264,P50336 6 +Regulation of appetite 0.9722856211281394 1.5967802295675844 0.1103147044235222 1.0 0.7006901876619157 2 P80303 1 +Regulation of response to food 0.9722856211281394 1.5967802295675844 0.1103147044235222 1.0 0.7006901876619157 2 P80303 1 +Negative regulation of response to food 0.9722856211281394 1.5967802295675844 0.1103147044235222 1.0 0.7006901876619157 2 P80303 1 +Antigen processing and presentation of peptide antigen via mhc class i 0.5855789606749838 1.5943324191838784 0.1108616001871367 1.0 0.7006901876619157 11 Q9UIQ6,P10321,Q03519 3 +Endothelial cell migration 0.459126265287924 1.5940673989100975 0.1109209398720358 1.0 0.7006901876619157 34 P25705,P57105,P42785,P09601,Q8WTV0 5 +Smooth muscle contraction 0.6588269994306528 1.5929797678872202 0.1111647298855265 1.0 0.7006901876619157 7 P00813,Q12959 2 +Autophagosome membrane docking 0.7908646003262527 1.591489469004427 0.1114994635621982 1.0 0.7011855510921043 4 P16615,Q96GC9,P56962 3 +Hepaticobiliary system development 0.4587471406965239 1.5908782139559778 0.1116369863953334 1.0 0.7011855510921043 34 O94788,P09601,P00813,O75844,P11717,P25325,Q15418,Q96JB5 8 +Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.5341823372909452 1.58960742435327 0.1119233225134577 1.0 0.7014084215033062 14 P50570,Q07954,Q92896 3 +Cellular copper ion homeostasis 0.787951474873812 1.5796332747469577 0.1141908744131621 1.0 0.710249465951127 4 P35670,O60826 2 +Negative regulation of leukocyte mediated immunity 0.6901662897844749 1.5724146593218982 0.115854416742088 1.0 0.7168549894585104 6 P09601,P46108,P04439 3 +Protein localization to phagophore assembly site 0.7222889880964071 1.5691813423690406 0.1166056903547407 1.0 0.7168549894585104 5 P56962,Q7Z3C6 2 +Response to estrogen 0.5482626165648498 1.5677160335062306 0.1169474181369665 1.0 0.7168549894585104 13 Q9H6U6,Q8IZL8,P09601 3 +Phosphatidylcholine catabolic process 0.9647864362569322 1.5670957957614071 0.1170923017692182 1.0 0.7168549894585104 2 Q8WTV0 1 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.6886610612512697 1.5655937893263052 0.1174437448957892 1.0 0.7168549894585104 6 O43657,Q9NUD5,Q14671 3 +Neurofilament cytoskeleton organization 0.9641343332246496 1.5645138850727054 0.1176969347510181 1.0 0.7168549894585104 2 P07196 1 +Double strand break repair via break induced replication 0.636865487245317 1.559979958113579 0.1187646174538006 1.0 0.7177513837425342 8 Q14566,P33991 2 +Sterol metabolic process 0.4563495507016539 1.5533036979928367 0.120350597225034 1.0 0.723915069291503 32 P34913,P37268,Q14739,Q8WTV0,P48449,O15118,Q15392,Q15800,P16435,P04062,Q16850 11 +Appendage development 0.5770496059937731 1.5466775171070573 0.1219410271523455 1.0 0.724169720118896 11 O94788,P42892 2 +Glycine metabolic process 0.684489156524299 1.5466718832208592 0.1219423863666335 1.0 0.724169720118896 6 P00374,P34897,O75600 3 +Centriole assembly 0.6842039031614416 1.54537719425196 0.1222550533190007 1.0 0.7244659971470723 6 Q96PK6 1 +Positive regulation of histone deacetylation 0.716391773503015 1.5436648768074746 0.1226695393050532 1.0 0.7262491058486206 5 O43823 1 +Regulation of steroid metabolic process 0.5254946844811252 1.5349460322996604 0.1247970850061417 1.0 0.7353145147330218 14 P34913,Q13510,P30536,O75477,Q9UHI6,P16435 6 +Membrane protein ectodomain proteolysis 0.5960562787452277 1.5344391241937734 0.1249216587353938 1.0 0.7353145147330218 10 P38159,O43847,Q13464 3 +N terminal protein amino acid modification 0.6316395431942935 1.534097096515622 0.1250057675187355 1.0 0.7353145147330218 8 P53582,Q9BV86,Q86UY6,Q5VZE5 4 +Ion homeostasis 0.3966613079277263 1.5330989842119147 0.1252514679482164 1.0 0.7353712592043462 108 O43819,Q8TAD4,Q93050,Q14344,Q15043,P08133,Q16891,Q13586,Q8IYU8,P30536,Q96A33,P30519,P07686,P02786,P51790,Q9BPX6,Q8N511,Q15904,Q9Y487,P09601,Q8NE01,P50897,Q96TC7,O75503,O75027,Q8NEW0,P16615,Q9HD20,Q9H4A3,Q14BN4,P35670,P62942,O60826,Q6P4Q7,P48507,Q8WWC4,Q9H4I9,Q9Y6M7 38 +Dna templated transcription termination 0.6304765570788724 1.528330390521815 0.1264305280891686 1.0 0.7353712592043462 8 O75844,O95104,Q16637 3 +Amide transport 0.4421517234424914 1.524270988577521 0.1274410311846916 1.0 0.7353712592043462 40 P07602,P41440,O15439,P08183,P53985 5 +Neuron projection regeneration 0.5728131226265715 1.5229447682525497 0.1277725241455369 1.0 0.7353712592043462 11 Q96G23,P07196 2 +Lens development in camera type eye 0.6790722458058273 1.5220666128234823 0.1279923906369848 1.0 0.7353712592043462 6 Q12959,P08670 2 +Apoptotic cell clearance 0.6290669536082749 1.5213376073405465 0.128175137379513 1.0 0.7353712592043462 8 Q8WTV0 1 +Regulation of mast cell activation involved in immune response 0.7724734247716548 1.5165098116861504 0.1293904912384902 1.0 0.7353712592043462 4 P09601 1 +Sodium ion transport 0.454400927588101 1.5121642410836105 0.1304920854614575 1.0 0.7353712592043462 27 P50570,O43865,Q9H2J7,Q6P4Q7,Q12959,Q96QD8,O43707,Q9H4A3,Q9Y6M7,Q14BN4,P46939 11 +Cristae formation 0.6271329776652981 1.5117378356891449 0.1306005693001579 1.0 0.7353712592043462 8 Q9NX63,Q16891,Q5XKP0 3 +Negative regulation of mrna catabolic process 0.454787888311159 1.5116275945020796 0.130628627668039 1.0 0.7353712592043462 24 Q92804,P35637,Q14011,O60506,P98175,P67809 6 +Retinoic acid metabolic process 0.9557331525770943 1.5105966163825095 0.1308912565834616 1.0 0.7353712592043462 3 Q9HB40 1 +Amyloid precursor protein biosynthetic process 0.708695386830783 1.51030279997762 0.1309661776108488 1.0 0.7353712592043462 5 P35610,Q9NQX7,Q96IZ0 3 +Nuclear transcribed mrna catabolic process exonucleolytic 3 5 0.6265152511296939 1.5086702268221008 0.1313830777398759 1.0 0.7353712592043462 8 Q9NQT5,Q5RKV6 2 +Amino acid transmembrane transport 0.5103680411067548 1.5054020834006496 0.1322207337845009 1.0 0.7353712592043462 16 P08195,P30825,Q9H2J7,Q96QD8,Q8TDW0 5 +Import across plasma membrane 0.4849740868243923 1.5045582044299164 0.1324376985897963 1.0 0.7353712592043462 20 P08195,P41440,Q15043,P33121,P30825,Q12959,Q9H4A3,Q8TDW0 8 +Regulation of low density lipoprotein particle clearance 0.7069339853079855 1.502658272508401 0.1329271882327503 1.0 0.7353712592043462 5 Q92945 1 +Odontogenesis 0.639861104437478 1.5020413334310645 0.1330864344404942 1.0 0.7353712592043462 7 P07942,Q13586,Q6P4Q7 3 +Positive regulation of actin cytoskeleton reorganization 0.7687522741092622 1.5013039764440568 0.1332769569691017 1.0 0.7353712592043462 4 Q9H6U6,Q9UQB8 2 +Regulation of glycoprotein metabolic process 0.5530361632187283 1.4983442106024871 0.1340438431416415 1.0 0.7353712592043462 12 O14734,Q99805,Q9NQX7,Q08379,P35610,Q96IZ0 6 +Neuron death 0.3654419045385287 1.4975276752467412 0.1342560099612988 1.0 0.7353712592043462 64 O95831,Q99720,Q9UL15,Q9NR28,P09601,P07196,P50897,Q01105,Q9UMX5,Q15392,O43813,Q15233 12 +Negative regulation of rna splicing 0.5030145746680621 1.494818232614271 0.1349618866033153 1.0 0.7353712592043462 17 Q13242,Q16629,Q9UKA9,P61978,P38159,P98175,O75494,P22626 8 +B cell proliferation 0.5878912410866851 1.4906704922078606 0.1360480268650661 1.0 0.7370459351331204 10 P00813,P14174,Q96IZ0 3 +Cell activation involved in immune response 0.4429049647750033 1.4887361664968126 0.1365568573408884 1.0 0.7378705551386665 37 P00813,Q07954,P09601,Q5RKV6 4 +Gdp metabolic process 0.7036553524804334 1.4884201168159743 0.1366401346097883 1.0 0.7378705551386665 5 Q14168,Q12959,Q00013,O14936 4 +Nucleoside triphosphate catabolic process 0.7034591380577304 1.487567657474172 0.1368649481380135 1.0 0.7378705551386665 5 P00813 1 +Deoxyribonucleoside triphosphate catabolic process 0.7034591380577304 1.487567657474172 0.1368649481380135 1.0 0.7378705551386665 5 P00813 1 +Negative regulation of nitric oxide metabolic process 0.764066772694728 1.4821424295032224 0.1383024011353333 1.0 0.740714534298016 4 P30536,Q92945 2 +Cell recognition 0.488523104596154 1.4814301025310652 0.1384919980733732 1.0 0.740714534298016 19 Q5KU26,P45880,Q8WTV0 3 +Determination of adult lifespan 0.6355305836343472 1.4811948506881194 0.1385546579888028 1.0 0.740714534298016 7 O75844,P46100 2 +Regulation of water loss via skin 0.6974153658967186 1.4612912596454923 0.1439355274741904 1.0 0.7504122280496768 5 Q9Y3B8,P04062,P16949 3 +Positive regulation of i kappab kinase nf kappab signaling 0.4458285076779984 1.4593117083435283 0.144479334310247 1.0 0.7510296006431681 31 Q92734,O60885,Q9NYB0,Q8TB61,P62942,O60826,P09601,P19474,P02786,O43657,P32929,Q99584 12 +Copper ion homeostasis 0.6955914397415055 1.453354386608795 0.1461253840806846 1.0 0.7510296006431681 5 P35670,O43819,O60826 3 +3 utr mediated mrna stabilization 0.6284100772200998 1.4468565015777606 0.1479371181429614 1.0 0.7510296006431681 7 P07910,P98175,Q13151 3 +Regulation of mitophagy 0.6283538839980239 1.4465852197437392 0.148013128247415 1.0 0.7510296006431681 7 P21796 1 +Positive regulation of rna splicing 0.4464929543912468 1.4463414451603978 0.1480814565811898 1.0 0.7510296006431681 24 O75312,P62995,Q13243,Q8WVV9,Q9Y2W1,Q14011,P38159,Q96QD8,Q96E39,Q96EP5,P98179 11 +Regulation of metallopeptidase activity 0.7548779234391636 1.4445193814763582 0.1485929318777681 1.0 0.7510296006431681 4 Q07954 1 +Regulation of lipid transport 0.4952859318222696 1.443014226917419 0.1490164635618609 1.0 0.7510296006431681 17 P30536,Q07954,P14174,O15260 4 +Regulation of cell aging 0.527588446506677 1.4424612862428563 0.1491722853951866 1.0 0.7510296006431681 13 O75844,P14174,P02545,P67809 4 +I kappab kinase nf kappab signaling 0.4270910731769515 1.4394795754826022 0.1500146927151413 1.0 0.7514893260482242 43 Q92734,O60885,Q9NYB0,Q8TB61,P62942,O60826,Q13162,P09601,Q9P035,P19474,P02786,Q96HY6,Q96CV9,O43657,P32929,Q13464,Q99584 17 +Collagen biosynthetic process 0.7531764429523793 1.437546796744004 0.150562685832801 1.0 0.7514893260482242 4 P08670 1 +Pyrimidine deoxyribonucleotide metabolic process 0.6916840003567966 1.4363406130383596 0.1509054428524066 1.0 0.7514893260482242 5 Q9H773 1 +Positive regulation of mitochondrial calcium ion concentration 0.6916811103914992 1.4363280244249568 0.1509090232477197 1.0 0.7514893260482242 5 Q9BPX6,Q96AQ8,Q8IYU8 3 +Regulation of dna methylation 0.6259286714006284 1.434872893477212 0.1513233212702747 1.0 0.7527747209823971 7 Q8NB78,O75844 2 +Collagen metabolic process 0.5965813880245883 1.4332441514329557 0.151788076130878 1.0 0.7527747209823971 9 P08670,Q92791 2 +Mitochondrion distribution 0.7517178991576003 1.4315683690659462 0.1522673874602498 1.0 0.7527747209823971 4 O75153,Q9BUK6 2 +Postsynaptic cytoskeleton organization 0.7516793394443274 1.4314102995918825 0.1523126582694809 1.0 0.7527747209823971 4 P07196 1 +Isoprenoid metabolic process 0.4603486159436618 1.4311219968598736 0.1523952540287241 1.0 0.7527747209823971 22 P37268,Q9HB40,O94788,Q07954 4 +Proteoglycan metabolic process 0.6587192078006379 1.4292770103234864 0.152924630976452 1.0 0.7527747209823971 6 Q7LGA3 1 +Keratinization 0.929572872513857 1.4276113158990262 0.1534037647289889 1.0 0.7527747209823971 2 Q9Y3B8 1 +Cellular response to oxygen levels 0.4393962468711239 1.4272674878840022 0.1535028081752965 1.0 0.7527747209823971 34 Q9Y487,P09601,Q8N511,P55786 4 +Negative regulation of glial cell proliferation 0.9329753981551095 1.4269528535344722 0.1535934846638502 1.0 0.7527747209823971 3 Q96G23 1 +Positive regulation of b cell proliferation 0.7505247525259031 1.426676853788948 0.1536730603249512 1.0 0.7527747209823971 4 P00813,P14174 2 +Response to hydrogen peroxide 0.4431408445429299 1.424094888032113 0.1544190060198405 1.0 0.7527747209823971 28 O95831,O60658,P03915,P09601,Q99720 5 +Regulation of sodium ion transport 0.4924623804606701 1.424049532665706 0.1544321340062686 1.0 0.7527747209823971 17 P50570,O43865,Q12959,O43707,Q9H4A3,Q14BN4 6 +Positive regulation of sodium ion transmembrane transporter activity 0.6574269726495013 1.42336913521542 0.1546291749703319 1.0 0.7527747209823971 6 P50570,O43707 2 +Cellular response to estrogen stimulus 0.6886678256788085 1.4231982469914526 0.1546786936565496 1.0 0.7527747209823971 5 Q8IZL8 1 +Positive regulation of chemokine production 0.657254035569571 1.4225783590658028 0.1548584211536769 1.0 0.7527747209823971 6 P09601 1 +Semaphorin plexin signaling pathway involved in neuron projection guidance 0.9279426149331664 1.421154726932095 0.1552717829485455 1.0 0.7527747209823971 2 P42892 1 +Glycerophospholipid catabolic process 0.6563949099036479 1.4186494235726574 0.1560012491743796 1.0 0.7527747209823971 6 Q8WTV0 1 +Xenobiotic export 0.9272905119008864 1.418572228425332 0.1560237672175461 1.0 0.7527747209823971 2 P08183 1 +Microtubule organizing center organization 0.4333432298903285 1.417658983974733 0.1562903504029713 1.0 0.7527747209823971 38 Q9H6D7,Q08379,Q7Z4H7,Q96PK6,Q9H6U6,P41208,P53985,Q14203,O94927,Q9HD42,P36404,O14777,Q8WUM4,Q15004,Q15154,P06493,Q9UBK9,Q9UNZ2,O75116 19 +Sno s rna processing 0.5933849672409062 1.41673414933534 0.1565606688188809 1.0 0.7527747209823971 9 Q9NQT5,Q5RKV6 2 +Lipopolysaccharide mediated signaling pathway 0.6070622463385765 1.4117484826776372 0.1580240323293558 1.0 0.754597208897611 8 Q8WTV0 1 +Positive regulation of isotype switching 0.5923424849042984 1.411346052208146 0.1581426016940357 1.0 0.7545998471878091 9 Q9NQT5,P02786,Q5RKV6 3 +Endocytosis 0.3840004730389555 1.4075153369259203 0.1592746326805503 1.0 0.7566395477320964 105 P20645,Q5KU26,Q5VW38,O14976,P41440,Q14C86,P61978,Q14108,Q07954,P57105,Q8WTV0,P50897,Q08380,P11717,O15118,O00291,O15260 17 +Mast cell activation involved in immune response 0.6201833881468317 1.4070946675310405 0.1593993191335183 1.0 0.7566395477320964 7 O95219,P09601 2 +Syncytium formation 0.6201693816562864 1.407026893517264 0.1594194142629996 1.0 0.7566395477320964 7 Q14012,P41440 2 +Connective tissue development 0.4489491859642976 1.4027489276532514 0.1606917215332342 1.0 0.7586022602178548 23 Q15043,P08133,O15173,O75844,Q96HY6,Q92896 6 +Macromolecule depalmitoylation 0.6528912297752245 1.4026184055302882 0.1607306603125176 1.0 0.7586022602178548 6 P50897,Q9UMR5 2 +Mrna splice site selection 0.4833876929859642 1.4021983096345665 0.1608560362924318 1.0 0.7586022602178548 18 Q13242,Q9UKA9,O75494,Q07955,Q9UHX1 5 +Negative regulation of rna catabolic process 0.4381615841375941 1.4017218560461884 0.1609983214131418 1.0 0.7586022602178548 32 Q14103,Q92804,P35637,Q14011,O60506,Q9H7Z3,P98175,Q99729,Q08J23,P67809 10 +Ion transmembrane transport 0.4247908042017323 1.399013866559106 0.1618088248806237 1.0 0.7604649753164407 161 O43865,Q9UDW1,O43772,Q8TAD4,Q15043,P25705,P08133,O15439,P00846,Q8IYU8,O43707,Q8TDW0,P45880,P21796,P51790,Q9BPX6,Q9UHG3,O75844,P08183,P53985,Q70HW3,P50570,Q96GC9,P41440,P30825,O75964,O75027,Q9H2J7,Q13423,Q9HD20,P00403,Q14BN4,Q9C0H2,P35670,P62942,P03915,Q6P4Q7,Q8WWC4,Q9BQT8,Q9H4I9,Q9UBX3 41 +Regulation of triglyceride metabolic process 0.9217476361265162 1.396624736923401 0.1625264475375909 1.0 0.7624314787640178 2 Q8WTV0 1 +Rrna catabolic process 0.5195127476575899 1.393269463918844 0.1635383209981937 1.0 0.7644481304860721 13 Q9NQT5,Q13868,Q5RKV6 3 +Protein hydroxylation 0.5029304659038613 1.392055905469275 0.1639054694321378 1.0 0.7644481304860721 14 Q32P28,P13674,Q92791,Q13162,O75718,O15460 6 +Urogenital system development 0.4303853144976324 1.3916203046454392 0.1640374069263503 1.0 0.7644481304860721 38 P07602,O94788,P39210,P57740,P25325,P46379,O75844,Q12769,Q12959,O00592 10 +Lymphocyte apoptotic process 0.4977011187478062 1.388723628884295 0.1649168061676773 1.0 0.7644481304860721 15 P00813,P14174,Q96GD4 3 +Positive regulation of lipid transport 0.58795041160786 1.3886271528140628 0.1649461562096945 1.0 0.7644481304860721 9 Q07954,P14174 2 +Bone remodeling 0.5879366668731651 1.388556009845862 0.1649678019102638 1.0 0.7644481304860721 9 O14773,Q92791 2 +Neural crest cell migration 0.740780128589815 1.386698558563013 0.1655337003287447 1.0 0.7644481304860721 4 P08133 1 +Transmembrane transport 0.4566017576334409 1.3866847832083633 0.1655379026323522 1.0 0.7644481304860721 219 Q9H2V7,O43865,Q9UDW1,Q99595,O43772,Q8TAD4,Q6NT16,Q15043,P25705,O15439,Q8WTV0,Q8IXU6,P00846,P39210,Q8IYU8,P08133,Q9NS69,O43707,Q9Y584,O60830,P45880,P21796,Q8TDW0,Q9BPX6,P51790,Q9Y277,Q9UHG3,O75381,Q03519,O75844,Q96QD8,P08183,P53985,Q16625,Q70HW3,P50570,O95831,Q96GC9,P41440,P30825,O75964,O75027,Q9H2J7,P16615,Q13423,Q9HD20,P00403,Q9H4A3,Q3ZCQ8,Q14BN4,Q9C0H2,P35670,Q99523,Q15629,P62942,P03915,Q6P4Q7,P23786,Q8WWC4,Q12959,Q9BQT8,Q96ES6,Q9H4I9,Q9UBX3,P04062 65 +Cellular response to osmotic stress 0.5339020679105101 1.38643506899296 0.1656140942583044 1.0 0.7644481304860721 12 P30536,Q9BPX6 2 +Regulation of platelet derived growth factor receptor beta signaling pathway 0.9188131724812572 1.3850086935052333 0.1660498091193458 1.0 0.7644481304860721 2 Q07954 1 +Rna interference 0.5865622969310562 1.3814408511672591 0.1671434526081932 1.0 0.7644481304860721 9 Q5KU26,Q15631,O75569 3 +Forelimb morphogenesis 0.9203059772712578 1.3803589751269905 0.1674761449930988 1.0 0.7644481304860721 3 O94788 1 +Sprouting angiogenesis 0.5008416271435411 1.378769385043783 0.1679658687798371 1.0 0.7644481304860721 14 P09601 1 +Protein localization to condensed chromosome 0.5857755801576006 1.3773667591371117 0.1683988846252382 1.0 0.7644481304860721 9 Q96GD4,Q96DY7,O14777 3 +Phagocytosis recognition 0.9168568633844234 1.3772661276335847 0.1684299835647746 1.0 0.7644481304860721 2 Q8WTV0 1 +Nucleotide salvage 0.6473141203535562 1.3770749941372402 0.1684890629108701 1.0 0.7644481304860721 6 P00813 1 +Heparan sulfate proteoglycan biosynthetic process 0.6780583934092259 1.3769107917305825 0.1685398302790006 1.0 0.7644481304860721 5 Q7LGA3 1 +Proteoglycan biosynthetic process 0.6780583934092259 1.3769107917305825 0.1685398302790006 1.0 0.7644481304860721 5 Q7LGA3 1 +Heparan sulfate proteoglycan metabolic process 0.6780583934092259 1.3769107917305825 0.1685398302790006 1.0 0.7644481304860721 5 Q7LGA3 1 +Regulation of isotype switching 0.5467300549455965 1.3760048500986968 0.1688201316898663 1.0 0.7644481304860721 11 Q9NQT5,P02786,Q5RKV6 3 +Fat soluble vitamin metabolic process 0.64688047973483 1.3750876537497982 0.1691042715275834 1.0 0.7644481304860721 6 Q8N0U8,O94788 2 +Prostaglandin transport 0.9162047603521402 1.3746855542256975 0.1692289516824248 1.0 0.7644481304860721 2 O15439 1 +Positive regulation of endothelial cell migration 0.4665151837648598 1.372458498137742 0.1699207501126718 1.0 0.7644481304860721 20 P09601,Q8WTV0,P25705 3 +Fatty acid transmembrane transport 0.6457754155567483 1.370022451168411 0.1706798934086539 1.0 0.7644481304860721 6 O43772 1 +Transmembrane receptor protein serine threonine kinase signaling pathway 0.421376088632261 1.369239403528299 0.1709244526971738 1.0 0.7644481304860721 42 P50570,Q8N1F7,P49354,Q07954,Q96PK6,P08670,Q9UIQ6,Q92896 8 +Manganese ion transmembrane transport 0.914248451255305 1.3669447342270171 0.1716426288670844 1.0 0.7644481304860721 2 Q9HD20 1 +Manganese ion transport 0.914248451255305 1.3669447342270171 0.1716426288670844 1.0 0.7644481304860721 2 Q9HD20 1 +Iron ion transmembrane transport 0.9142484512552972 1.3669447342269876 0.1716426288670938 1.0 0.7644481304860721 2 O75027 1 +Tail anchored membrane protein insertion into er membrane 0.5647830958485986 1.3661265055410357 0.1718992602470546 1.0 0.7644481304860721 10 P46379 1 +Nucleobase containing small molecule catabolic process 0.6752927080793796 1.3648308138056402 0.1723062315657593 1.0 0.7644481304860721 5 P00813 1 +Deoxyribose phosphate catabolic process 0.6112672744147013 1.3639026573928907 0.1725982043667036 1.0 0.7644481304860721 7 P00813,Q9H773 2 +Purine ribonucleotide salvage 0.6745074471516315 1.361400011335122 0.1733873125419305 1.0 0.7644481304860721 5 P00813 1 +Purine nucleotide salvage 0.6745074471516315 1.361400011335122 0.1733873125419305 1.0 0.7644481304860721 5 P00813 1 +Amp salvage 0.6745074471516315 1.361400011335122 0.1733873125419305 1.0 0.7644481304860721 5 P00813 1 +Entrainment of circadian clock 0.6734342405615366 1.3567105300150184 0.1748732053255983 1.0 0.7644481304860721 5 Q9BWF3 1 +Negative regulation of proteolysis 0.3658803833256975 1.3561545148838472 0.1750500107043267 1.0 0.7644481304860721 61 Q9UL15,Q07954,P46379,P51812,Q15418,Q96HY6,Q15392,Q92896 8 +Purine deoxyribonucleotide metabolic process 0.7323427903474512 1.352048807465716 0.1763597022358287 1.0 0.7644481304860721 4 P00813 1 +Entry of bacterium into host cell 0.9121350715152462 1.3503102885832827 0.1769164734887327 1.0 0.7644481304860721 3 Q9BTY2 1 +Regulation of entry of bacterium into host cell 0.9121350715152462 1.3503102885832827 0.1769164734887327 1.0 0.7644481304860721 3 Q9BTY2 1 +Regulation of steroid biosynthetic process 0.5617977081303196 1.349972753912278 0.1770247226719483 1.0 0.7644481304860721 10 P30536,Q9UHI6,P16435,Q13510 4 +Lymphocyte activation involved in immune response 0.4333727113648191 1.3418167841037612 0.1796554087614201 1.0 0.7689150690890312 25 P00813,Q9UQ84,P02786,Q5RKV6 4 +Digestive system development 0.5262600649156566 1.3415456720385823 0.179743351565627 1.0 0.7689150690890312 12 P00813 1 +Carbohydrate mediated signaling 0.669348817094255 1.338852380934469 0.1806187344355159 1.0 0.7689150690890312 5 Q5KU26 1 +Positive regulation of t cell proliferation 0.5594802406386421 1.3374243497115683 0.181084160651644 1.0 0.7689150690890312 10 P30825,P49366,P02786,P04439 4 +Cell adhesion molecule production 0.9083212703256648 1.3362872633908394 0.1814553979129709 1.0 0.7689150690890312 3 P41440 1 +Positive regulation of cell adhesion molecule production 0.9083212703256648 1.3362872633908394 0.1814553979129709 1.0 0.7689150690890312 3 P41440 1 +Cellular component disassembly involved in execution phase of apoptosis 0.6383079461878576 1.335766511961453 0.1816256018859596 1.0 0.7689150690890312 6 O95831 1 +Embryonic digestive tract development 0.9076939684433872 1.3339809336580517 0.1822101051963605 1.0 0.7691104931926759 3 P00813 1 +3 utr mediated mrna destabilization 0.6377233956915862 1.3330830452826907 0.1825045526751749 1.0 0.7694528069731266 6 Q92945 1 +Regulation of epithelial cell migration 0.420524301644392 1.330550277158106 0.1833370326344405 1.0 0.7717294184757162 40 P25705,P57105,P42785,P09601,Q8WTV0 5 +Purine nucleotide transport 0.5088726653829287 1.3282673683456918 0.1840897957635296 1.0 0.7733706663022397 13 P41440,Q8TB61,Q99808,O15439,Q8TDW0 5 +Nerve development 0.58988018853018 1.3256908122038835 0.1849421319740603 1.0 0.7749148046147716 8 P42892 1 +Epithelial cell proliferation 0.4163810928757929 1.3234494695615828 0.1856859497911851 1.0 0.7754905048757922 42 O94788,P25705,Q9Y3B8,P57105,P09601,O14936,Q8WTV0,P07942,Q00577,Q15418,P22392,P15531 12 +Protein targeting to lysosome 0.5370066757637322 1.3209177426891423 0.1865287930517407 1.0 0.7758314347747025 11 P20645,Q14108,Q9Y2T2 3 +Negative regulation of inflammatory response 0.5069394808197324 1.3164368600537435 0.1880274575796252 1.0 0.7771308513882371 13 P28070,P00813 2 +Regulation of rna polymerase ii regulatory region sequence specific dna binding 0.9008803390935824 1.3140932040038842 0.1888148408768288 1.0 0.7771308513882371 2 Q96HY6 1 +Gmp salvage 0.7229296961708667 1.3133643499884489 0.1890602043002731 1.0 0.7771308513882371 4 P00813 1 +Intermediate filament organization 0.6328565965940717 1.3107314255620004 0.1899485175881849 1.0 0.7776152046025925 6 P07196,P08670 2 +Purine containing compound transmembrane transport 0.5543558121128802 1.309651666809934 0.1903137013397198 1.0 0.7776152046025925 10 Q8TDW0,O15439,P41440,Q8TB61 4 +Negative regulation of mitochondrion organization 0.4896853031092315 1.307669466555381 0.1909854439663081 1.0 0.7792986143717767 14 P30536,P02786,P02545,Q9Y255 4 +Astrocyte differentiation 0.534493915697009 1.3066596218434203 0.1913283378259407 1.0 0.7801919401151736 11 Q07954,P08670 2 +Purine nucleoside metabolic process 0.5719579078937715 1.3056755283831047 0.1916629234025466 1.0 0.7801919401151736 9 P00813,Q13126,P55263 3 +Proton transmembrane transport 0.4126155584892905 1.3055878708255122 0.1916927472824723 1.0 0.7801919401151736 43 Q9UDW1,P25705,Q8TAD4,O75964,P03915,P00846,Q13423,O43707,P00403 9 +Negative regulation of nervous system development 0.4893572013679225 1.3055752873607196 0.1916970288562693 1.0 0.7801919401151736 14 Q96G23 1 +Positive regulation of pattern recognition receptor signaling pathway 0.5851094723768829 1.301734751293827 0.1930070756148625 1.0 0.7812739854529719 8 Q9NUD5,Q14671,P41440 3 +Neutral amino acid transport 0.6308131356307389 1.3013415575656115 0.1931415683663941 1.0 0.7812739854529719 6 Q96QD8,P08195,Q9H2J7 3 +Regulation of phospholipase activity 0.5706534835117223 1.2988956594178165 0.1939797395000626 1.0 0.7812739854529719 9 P50897 1 +Endothelial cell proliferation 0.4560261821360901 1.2970167856105312 0.1946254113535173 1.0 0.7812739854529719 20 P57105,P09601,Q8WTV0,O94788 4 +Acute inflammatory response 0.718852050454359 1.29660059508864 0.1947686476090142 1.0 0.7812739854529719 4 P42785 1 +Amyloid precursor protein catabolic process 0.4733830549179177 1.2954382621946965 0.1951690859845682 1.0 0.7823894268246581 17 P62942,Q9NQC3,P27695,Q96P70,O95197,P49755,Q15392,Q13464,Q13492 9 +Negative regulation of release of cytochrome c from mitochondria 0.6285767937312232 1.291062326808101 0.1966820661441306 1.0 0.7855945247499672 6 P02545 1 +Organic anion transport 0.3979688079591591 1.290994618359108 0.1967055436405125 1.0 0.7855945247499672 49 Q14728,P14174,P08195,P07602,P41440,Q8TB61,Q99808,P30825,Q9H2J7,O15439,Q96QD8,Q9Y6M7,Q9BQT8,P53985,Q8TDW0,Q9UBX3 16 +N terminal protein amino acid acetylation 0.6555157074721418 1.2783218393945277 0.2011359704344744 1.0 0.7962840329058432 5 Q86UY6,Q5VZE5 2 +Multicellular organism aging 0.5288609302358716 1.2746673765831535 0.2024269985171343 1.0 0.798108791408089 11 Q14344,O75844,P04062,P46100 4 +Regulation of histone deacetylation 0.5927307435823016 1.27383477223589 0.2027219790373853 1.0 0.798108791408089 7 O43823 1 +Negative regulation of neuron death 0.4228742564272052 1.2734657874732809 0.2028528054673608 1.0 0.798108791408089 32 P09601,P07196,P50897,Q01105,Q9UMX5,Q15233 6 +Iron coordination entity transport 0.8904466905771111 1.2729129488887965 0.2030489337875645 1.0 0.798108791408089 2 O75027 1 +Heme transport 0.8904466905771111 1.2729129488887965 0.2030489337875645 1.0 0.798108791408089 2 O75027 1 +Mitotic g2 dna damage checkpoint signaling 0.5648223878458756 1.2685660972336892 0.2045958624998225 1.0 0.8001137277210185 9 Q96JB5,Q6NUQ1,Q9NWV8 3 +Histone h3 k4 demethylation 0.6530678851174876 1.2676028774700856 0.204939803843533 1.0 0.8009355205673798 5 Q8IUF8,Q8NB78,Q9H6W3,P29375 4 +Cellular response to molecule of bacterial origin 0.4239981414168896 1.266957945870648 0.2051703274106677 1.0 0.8009355205673798 27 P30536,Q8WTV0,P08670,O43823 4 +Positive regulation of blood vessel endothelial cell migration 0.5464393181595961 1.2666852341650283 0.2052678618356658 1.0 0.8009355205673798 10 P09601 1 +Cation transmembrane transport 0.3877244886682288 1.2662175640974858 0.2054352009106508 1.0 0.8009355205673798 124 Q9UDW1,O43772,Q8TAD4,Q15043,P25705,P08133,P00846,Q8IYU8,O43707,P51790,P21796,Q9BPX6,Q70HW3,P50570,Q96GC9,P30825,O75964,O75027,Q9H2J7,P16615,Q13423,Q9HD20,P00403,Q9H4A3,Q14BN4,P35670,P62942,P03915,Q6P4Q7,Q8WWC4,Q12959,Q96ES6,Q9H4I9 33 +Response to osmotic stress 0.451661279857838 1.2655609439452378 0.2056703163330875 1.0 0.8009355205673798 20 P30536,Q8TDW0,P08183,Q9BPX6 4 +Response to zinc ion 0.6520433174536249 1.2631158051570823 0.2065475647397283 1.0 0.8026034005974912 5 P30536,Q8TAD4 2 +Nuclear transcribed mrna catabolic process exonucleolytic 0.4978838498880918 1.260949254642836 0.2073271306714492 1.0 0.8026034005974912 13 Q969T7,Q9NQT5,Q13868,Q5RKV6 4 +Response to testosterone 0.5452346563908839 1.2601411580645665 0.2076184450823364 1.0 0.8026034005974912 10 P30536,Q13126 2 +Regulation of hormone metabolic process 0.6512019611858311 1.2594308988425151 0.2078747347312199 1.0 0.8026034005974912 5 O75844,P16435 2 +Endochondral bone morphogenesis 0.6511841032795059 1.2593526842780014 0.2079029716608444 1.0 0.8026034005974912 5 P08133,O75844 2 +Regulation of autophagy of mitochondrion 0.4730367066895089 1.2589890081232396 0.208034302132049 1.0 0.8026034005974912 16 P30536,P21796 2 +Positive regulation of mitophagy 0.6510648983026761 1.258830584964278 0.2080915305953232 1.0 0.8026034005974912 5 P21796 1 +Steroid metabolic process 0.3536217993303023 1.2576645840757568 0.2085130856214867 1.0 0.8026034005974912 62 P34913,P37268,O14734,Q9H3P7,Q14739,Q9H4L5,Q8WTV0,Q15800,Q13510,P30536,Q9UHI6,O15118,Q15392,P48449,P16435,P04062,Q16850 17 +Sensory perception 0.4212641981186757 1.2550090948496404 0.20947545839384 1.0 0.8026034005974912 31 P62072,Q14108,Q9H6K4,Q6P4Q7,P50897,O43924,Q9BPW8 7 +Response to arsenic containing substance 0.4810947005209172 1.25278867413504 0.210282624538646 1.0 0.8026034005974912 14 Q96QD8,P09601,P07196,Q9BWF3 4 +Chemokine production 0.5751833935366866 1.2518222404841235 0.210634644132265 1.0 0.8026034005974912 8 P09601 1 +Icosanoid transport 0.8851380219348522 1.2511188231058197 0.2108911290439228 1.0 0.8026034005974912 3 O15439 1 +Histone h3 k9 acetylation 0.7076105335235451 1.2503773224020385 0.211161744653801 1.0 0.8026034005974912 4 Q14012,Q03164 2 +Nadh dehydrogenase complex assembly 0.4217760199925697 1.2501509864717772 0.2112443974564346 1.0 0.8026034005974912 28 Q9H061,P03915,Q15070,Q96CU9,O96000,O43676 6 +Positive regulation of neural precursor cell proliferation 0.6193717585942355 1.248722876563997 0.2117664506459351 1.0 0.8026034005974912 6 P55209 1 +Muscle cell differentiation 0.3672855751413324 1.2480935640042423 0.2119967949498142 1.0 0.8026034005974912 58 P35579,Q99523,Q9BWF3,P02545,Q8IV08,P41440,P28289,Q96PU8,Q9NYL9,Q7Z4V5,O75844,P16615,O43707,P32929,P12814,Q14012,P67809 17 +Negative regulation of response to external stimulus 0.4063744077332831 1.2476606784645148 0.2121553470659158 1.0 0.8026034005974912 43 P28070,P14174,Q9UIV1,Q96G23,O14936,P46108,Q07021,P04439,P00813,P80303,P19474,Q9UMX5,O43657,P04062 14 +Striated muscle adaptation 0.7067388255902471 1.2467929954876138 0.2124734094968832 1.0 0.8026034005974912 4 P02545 1 +Regulation of nuclear cell cycle dna replication 0.8822361934322425 1.240472069618871 0.2148008387066029 1.0 0.8039566354379021 3 P46100 1 +Triglyceride metabolic process 0.5728454494856313 1.2400544940122866 0.214955238881241 1.0 0.8039566354379021 8 Q8WTV0 1 +Protein processing 0.4102732786107259 1.2381980396000982 0.2156426382796399 1.0 0.8039566354379021 40 O75976,Q96F07,Q8TAD4,O75503,Q6IQ49,O75844,Q5JRX3,Q9UG56,P42892,Q15392,Q92896,Q10713 12 +Associative learning 0.5410821529222636 1.237573229081153 0.2158743459807359 1.0 0.8039566354379021 10 Q13641,P50897 2 +Amino acid import across plasma membrane 0.6169296166833423 1.2374835422339443 0.2159076205866963 1.0 0.8039566354379021 6 P30825,P08195,Q15758 3 +Phospholipid dephosphorylation 0.7044045676998301 1.2371952001920103 0.2160146230344566 1.0 0.8039566354379021 4 P34913,Q13614,Q10713 3 +Plasma membrane organization 0.4201511066892501 1.2357633865673074 0.2165465282779575 1.0 0.8050778117497324 27 P50570,Q96GC9,Q7Z3C6,P41440,P08133,Q9UQB8,P16615,O15121,Q01082 9 +Peptidyl proline hydroxylation 0.5846719697552688 1.2345890352323328 0.2169834918185049 1.0 0.8056792596579436 7 O15460,Q32P28,P13674,O75718 4 +Regulation of histone h3 k9 trimethylation 0.61615494928286 1.2339178778120707 0.2172335069831552 1.0 0.8056792596579436 6 P46100 1 +Histone h3 k9 trimethylation 0.61615494928286 1.2339178778120707 0.2172335069831552 1.0 0.8056792596579436 6 P46100 1 +Regulation of t cell differentiation in thymus 0.8787088359961004 1.2266834764954064 0.2199415804866669 1.0 0.8107673450159197 2 P00813 1 +Intermediate filament bundle assembly 0.8780401391941455 1.2250842190982558 0.2205434903891741 1.0 0.8112404134383294 3 P07196 1 +Glial cell migration 0.5064305938945624 1.224680037575656 0.2206957983648947 1.0 0.8112404134383294 12 P30536,Q96G23,Q96N66 3 +Mrna methylation 0.6140247291233195 1.224111822763894 0.220910046637325 1.0 0.8112404134383294 6 Q96FX7 1 +Leukocyte proliferation 0.411352358573301 1.2234511915113058 0.2211593284137882 1.0 0.8112404134383294 38 P14174,P30825,P04439,P00813,P49366,Q12959,P02786,Q00577,Q96IZ0,P04062 10 +Dsrna processing 0.4674978664490998 1.2222220124867778 0.2216236817517822 1.0 0.8112404134383294 16 Q14671,Q15631,O75844,P22626,O75569 5 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.4716841236162583 1.2196261987544303 0.222606610145376 1.0 0.8112404134383294 15 Q9UQ84,P02786,Q5RKV6 3 +Somatic diversification of immunoglobulins involved in immune response 0.4716841236162583 1.2196261987544303 0.222606610145376 1.0 0.8112404134383294 15 Q9UQ84,P02786,Q5RKV6 3 +Cerebellar purkinje cell layer formation 0.8757743723508289 1.2151455383155545 0.2243105878242635 1.0 0.8121415054067614 2 Q7Z4L5 1 +Activation of innate immune response 0.4505545455589684 1.2145566293278576 0.2245352389682868 1.0 0.8124948036011467 19 Q9NUD5,Q96PK6,Q8WXF1,P23246,Q15233 5 +Negative regulation of smooth muscle cell migration 0.6404771443980001 1.2124482232473364 0.2253408509340411 1.0 0.813225163964317 5 Q14344,Q07954 2 +Meiotic cell cycle process 0.4144241865982825 1.2078039313493063 0.2271226889414483 1.0 0.8163139252903996 33 P35579,Q9NQS7,Q92791,Q08379,O14777,P46379,Q9Y2W6,P46100,Q08J23,Q9BTX1 10 +Vacuolar transport 0.4034776230112676 1.2048535679491297 0.2282598361024725 1.0 0.8176456222006103 42 P20645,P07602,O14976,Q9P253,Q14108,Q07954,P11717,O15118 8 +Purine deoxyribonucleoside triphosphate metabolic process 0.8722215822871807 1.2037625370514224 0.2286813733038335 1.0 0.8176456222006103 3 P00813 1 +Glycoprotein biosynthetic process 0.3914416044103641 1.2030218159505115 0.2289678784404303 1.0 0.8176456222006103 48 O14734,Q08379,P35610,Q7LGA3,Q2TAA5,Q99805,Q9Y5P6,Q10472,P04843,Q86SF2,Q8NAT1,Q96IZ0,Q9BT22,Q8TCJ2,O60502,Q9NQX7,P46977,O43505,P04844,O95394,O15118 21 +Myeloid leukocyte cytokine production 0.5654624566015173 1.202870251027977 0.2290265340451558 1.0 0.8176456222006103 8 P09601 1 +Negative regulation of proteasomal ubiquitin dependent protein catabolic process 0.4540976724379321 1.200244438255759 0.230044421365009 1.0 0.8189888809620645 18 Q9UL15,Q8N163,Q96HY6,P46379 4 +Neuromuscular process controlling balance 0.5015319822547035 1.1957478899229856 0.2317949567487121 1.0 0.8213275765425152 12 Q8IZL8,P07196,O14773 3 +Regulation of defense response to virus 0.4679188819617632 1.1950833999188273 0.2320544470191938 1.0 0.8213275765425152 15 O43657 1 +Odontogenesis of dentin containing tooth 0.6075708051489302 1.1943954037367066 0.232323333913877 1.0 0.8213275765425152 6 P35613,Q6P4Q7,Q13586 3 +Muscle cell development 0.4148035706967719 1.192426891172546 0.2330939013129425 1.0 0.8220967178473788 26 P02545,P28289,Q9NYL9,P06493,Q96HC4,O75844,P16615,O43707,P12814,Q15149 10 +Long chain fatty acid transport 0.5008900762980604 1.1919554657992395 0.2332787078556251 1.0 0.8220967178473788 12 P23786,O43772 2 +Leukocyte homeostasis 0.5008440131192329 1.19168331199744 0.2333854439387823 1.0 0.8220967178473788 12 P00813 1 +Reactive nitrogen species metabolic process 0.4525155833193459 1.1893030111611524 0.2343204508514222 1.0 0.8232216769578504 18 P50570,Q92945,O43169,P30536,P16435 5 +Regulation of release of cytochrome c from mitochondria 0.5135212245441413 1.1873853387333542 0.2350756603738324 1.0 0.823445068380006 11 Q96A26,P02545,Q9Y255 3 +Positive regulation of mitotic cell cycle spindle assembly checkpoint 0.6911666466546968 1.182783651020088 0.2368949015984007 1.0 0.823445068380006 4 P12270 1 +Gmp metabolic process 0.4567321155610228 1.182720647686296 0.2369198783377655 1.0 0.823445068380006 17 O14936,P00813,P55263,Q14168,P22234 5 +Positive regulation of rna export from nucleus 0.6909350286652061 1.1818320813770955 0.2372723355512458 1.0 0.8236261202576904 4 Q9H7Z3,Q07666 2 +Positive regulation of nucleobase containing compound transport 0.6909350286652061 1.1818320813770955 0.2372723355512458 1.0 0.8236261202576904 4 Q9H7Z3,Q07666 2 +Endoplasmic reticulum calcium ion homeostasis 0.6907053200101851 1.1808883758927262 0.2376470696849377 1.0 0.8240321928229349 4 P16615,Q96A33 2 +Regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.4130303090347919 1.179138549440276 0.2383430105573922 1.0 0.8242804324590438 25 P50570,Q07954,Q8N1F7,Q92896 4 +Sphingosine biosynthetic process 0.6895778879297039 1.176256875064278 0.2394922430666164 1.0 0.8250526968086782 4 Q13510 1 +Positive regulation of dna recombination 0.4124610926416818 1.1733465395286753 0.2406568663055486 1.0 0.8250526968086782 27 O95619,P35637,Q5RKV6,P02786,Q7Z4V5 5 +Divalent inorganic cation homeostasis 0.3700221904592284 1.1731614968803097 0.2407310491177976 1.0 0.8250526968086782 55 P05771,Q8TAD4,Q15043,Q14344,P08133,Q16891,Q13586,Q8IYU8,Q96A33,P07686,Q96AQ8,Q9BPX6,Q8NE01,Q96TC7,Q8NEW0,P16615,Q9HD20,P35670,P51572,P62942,Q6P4Q7,Q8WWC4,P27695,Q9H4I9 24 +Regulation of lipase activity 0.5110108247606501 1.1730854005028604 0.240761560505943 1.0 0.8250526968086782 11 P50897,Q99523,P16435,Q07954 4 +Lymphocyte homeostasis 0.559446468971414 1.172551118928847 0.2409758612359209 1.0 0.8250526968086782 8 P00813 1 +Pore complex assembly 0.4831060790987711 1.1702172491282203 0.2419135530194456 1.0 0.8250526968086782 13 P12270,Q8N1F7,P57740,Q9BTX1 4 +Regulation of smad protein signal transduction 0.630680249191673 1.1695278588692846 0.2421910237029472 1.0 0.8250526968086782 5 Q8N1F7,Q07954 2 +Nucleotide transmembrane transport 0.5457613793986131 1.1692298768754976 0.2423110268828412 1.0 0.8250526968086782 9 Q8TDW0,O15439,P41440 3 +Regulation of cholesterol metabolic process 0.6014465419955406 1.1661916326404005 0.2435369748287295 1.0 0.8250526968086782 6 P34913,P16435 2 +Regulation of peptidase activity 0.3383730226240119 1.164315844731899 0.2442960377165053 1.0 0.8250526968086782 75 P78318,O95831,Q96K76,Q96F07,Q9Y3B8,Q96A26,Q07954,Q9NR28,O43847,O00291,P51812,Q06323,Q96HY6,Q15418,Q9Y255,Q9UL46,Q15392,P16435 18 +Regulation of sterol transport 0.5566342203064819 1.158373956077088 0.2467114626069408 1.0 0.8273058559484591 8 Q07954 1 +Cell adhesion mediated by integrin 0.5436659796940437 1.1582975938660711 0.2467426129642964 1.0 0.8273058559484591 9 P00813,Q9H4A3,O00592 3 +T cell proliferation 0.4098358387887541 1.155555877708105 0.2478628643108988 1.0 0.8276703196070067 24 P30825,P04439,P49366,Q12959,P02786,Q96IZ0 6 +Alternative mrna splicing via spliceosome 0.3996556094742833 1.1553924453588893 0.2479297541796647 1.0 0.8276703196070067 41 P51114,P52272,P62995,P98175,Q9UHX1,Q13242,Q9BWF3,Q9Y5S9,Q14004,O75525,Q92841,Q96T37,Q9Y2W1,P38159,Q07955,P23246,Q07666,Q8IY67,P17844 19 +Nucleoside catabolic process 0.6844787191920116 1.155316301971219 0.2479609225879127 1.0 0.8276703196070067 4 P00813 1 +Negative regulation of lymphocyte mediated immunity 0.6843687623918184 1.1548648828237142 0.2481457620717284 1.0 0.8276703196070067 4 P46108,P04439 2 +Release of cytochrome c from mitochondria 0.4609559295881469 1.149675003445574 0.2502777534448814 1.0 0.8305395026727024 15 P02545,Q9Y3B8,Q96A26,Q9Y255,Q3ZCQ8 5 +Pinocytosis 0.5672216014260194 1.1495007786578393 0.2503495458604066 1.0 0.8305395026727024 7 P50897 1 +Regulation of syncytium formation by plasma membrane fusion 0.6259263003947693 1.1487063598928908 0.250677082486201 1.0 0.8305395026727024 5 P41440 1 +Positive regulation of syncytium formation by plasma membrane fusion 0.6259263003947693 1.1487063598928908 0.250677082486201 1.0 0.8305395026727024 5 P41440 1 +Amino acid betaine transport 0.8588196935115902 1.1486677499810778 0.2506930088637262 1.0 0.8305395026727024 2 O43772 1 +Response to estradiol 0.4607714366511134 1.148471605074603 0.2507739284743657 1.0 0.8305395026727024 15 O95831 1 +Lactation 0.5066655576212507 1.148327457065042 0.2508334083792238 1.0 0.8305395026727024 11 P35670,P00403,Q13505,P15531 4 +Inorganic ion transmembrane transport 0.3735076055067168 1.1476566054737551 0.2511103519413156 1.0 0.8305395026727024 118 Q9UDW1,Q8TAD4,Q15043,P25705,P08133,P00846,Q8IYU8,O43707,P51790,P21796,Q9BPX6,Q9UHG3,P50570,Q96GC9,O75964,O75027,Q9H2J7,P16615,Q13423,Q9HD20,P00403,Q9H4A3,Q14BN4,P35670,P62942,P03915,Q6P4Q7,Q8WWC4,Q12959,Q96ES6,Q9H4I9,Q9UBX3 32 +Platelet derived growth factor receptor beta signaling pathway 0.8568571018312876 1.1475717450328902 0.2511453995552388 1.0 0.8305395026727024 3 Q07954 1 +Nucleotide transport 0.4635412186989643 1.140428618044318 0.2541077757953744 1.0 0.833654642837176 14 P41440,Q8TB61,Q99808,O15439,Q8TDW0 5 +Establishment of protein localization to mitochondrial membrane 0.440061198997933 1.1404181842838237 0.254112120564538 1.0 0.833654642837176 19 Q9Y584,Q9NS69,P62072 3 +Regulation of mrna splicing via spliceosome 0.3436557499068738 1.1396102703642264 0.2544487046343744 1.0 0.8338125841906747 62 P51114,P62995,P98175,Q96EP5,P08621,Q9UHX1,Q13242,Q9BWF3,Q9Y5S9,Q96E39,P98179,O75525,Q07021,Q92841,Q96T37,Q9Y2W1,Q96PU8,P38159,Q07666,P22626,Q8IY67,Q16629,P61978,Q14011,P17844,O75494 26 +Cerebellar purkinje cell layer development 0.5651338175013847 1.1393161073562914 0.2545713325300274 1.0 0.8338125841906747 7 Q7Z4L5,P54802,P04062 3 +Muscle cell migration 0.4908983009707827 1.1329001564170245 0.2572561843175798 1.0 0.8383771878321128 12 Q14344,O15511,Q07954,P46108,Q13685,Q13464 6 +Positive regulation of protein polyubiquitination 0.6215679026471883 1.1296235648293889 0.258634877120298 1.0 0.8398063945204661 5 O75150 1 +Chondrocyte differentiation 0.5378618662466536 1.1280101366760686 0.2593156382072927 1.0 0.8398063945204661 9 Q15043,P08133,Q92896 3 +Microtubule anchoring 0.5208074763406103 1.127226421919702 0.2596467619946461 1.0 0.8398063945204661 10 O95684,O75381 2 +Cyclic gmp amp transmembrane import across plasma membrane 0.8512037959276415 1.1269455215719024 0.2597655151752587 1.0 0.8398063945204661 3 P41440 1 +Regulation of cysteine type endopeptidase activity 0.3897389347394867 1.1261064832531409 0.2601204501544742 1.0 0.8398063945204661 45 P78318,O95831,Q96F07,Q9Y3B8,Q96A26,O00291,Q9NR28,P51812,Q15418,Q96K76,Q15392,P16435 12 +Platelet derived growth factor receptor signaling pathway 0.5501222709243316 1.1255406581516152 0.2603599982749638 1.0 0.8398063945204661 8 Q07954 1 +Negative regulation of immune effector process 0.5202008728096753 1.1239228041792886 0.2610457761543401 1.0 0.8398063945204661 10 Q08722,P09601,P46108,P04439 4 +Meiotic cell cycle 0.381124819260552 1.1238401212828657 0.2610808573988152 1.0 0.8398063945204661 49 Q9H2V7,Q9UH99,P35579,Q9NQS7,Q92791,Q08379,O14777,P46379,Q9UQ84,Q9Y2W6,P46100,Q08J23,Q9BTX1 13 +Mitochondrial electron transport ubiquinol to cytochrome c 0.620004098153217 1.1227784851462013 0.2615315850532007 1.0 0.8398960094576421 5 Q9UDW1 1 +Regulation of cell adhesion mediated by integrin 0.5491430602166302 1.1206032679316076 0.2624567733624099 1.0 0.840755816071768 8 P00813,Q9H4A3,O00592 3 +Angiotensin activated signaling pathway 0.6756933115823631 1.1192705089149169 0.2630247531712686 1.0 0.8415279625814478 4 O75116,O43865,Q13464 3 +Mitochondrion endoplasmic reticulum membrane tethering 0.8489889106327386 1.118872759974156 0.263194425481781 1.0 0.8415279625814478 3 Q96GC9,O43865 2 +Leukocyte apoptotic process 0.4370028540587697 1.1188028371825172 0.2632242610514381 1.0 0.8415279625814478 19 P00813,P14174,Q96GD4 3 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.5483231310015463 1.116469038339345 0.2642214161098832 1.0 0.8431082703841165 8 P46379 1 +Regulation of protein folding 0.6742877944634652 1.1135084715116008 0.2654901120069981 1.0 0.8444835187225367 4 Q9UL15,O14737 2 +Response to acid chemical 0.4415000198791804 1.1130910066707431 0.2656693457573444 1.0 0.8444835187225367 18 Q14103,Q99729,O95831,Q9UQB8 4 +Hydrogen sulfide biosynthetic process 0.8490381480273868 1.110485680513365 0.2667897952363993 1.0 0.8444835187225367 2 P32929 1 +Hydrogen sulfide metabolic process 0.8490381480273868 1.110485680513365 0.2667897952363993 1.0 0.8444835187225367 2 P32929 1 +Positive regulation of heart rate 0.8487120965112651 1.1092154126684874 0.2673372652024994 1.0 0.8444835187225367 2 P00813 1 +Calcium ion import into sarcoplasmic reticulum 0.8487120965112454 1.1092154126684104 0.2673372652025327 1.0 0.8444835187225367 2 O75844 1 +Bone growth 0.8450750163078884 1.1046197333651868 0.2693243967571777 1.0 0.8459572914886757 3 P08133,O75844 2 +Growth plate cartilage development 0.8450750163078884 1.1046197333651868 0.2693243967571777 1.0 0.8459572914886757 3 P08133,O75844 2 +Regulation of lysosomal protein catabolic process 0.8445297994979265 1.1026355342586278 0.2701854723912298 1.0 0.8465972691379475 3 Q07954 1 +Regulation of protein catabolic process in the vacuole 0.8445297994979265 1.1026355342586278 0.2701854723912298 1.0 0.8465972691379475 3 Q07954 1 +Clathrin dependent endocytosis 0.4536790818340892 1.102208784301031 0.2703709139161228 1.0 0.8465972691379475 15 O00291,Q5VW38,O14976 3 +Protoporphyrinogen ix metabolic process 0.6150429804092451 1.1010708045524895 0.2708658424417245 1.0 0.8477318632268168 5 P36551,P22830 2 +Glycoprotein catabolic process 0.8461036843821339 1.0990593680258758 0.2717421713805414 1.0 0.849642759807913 2 O60502 1 +Metal ion transport 0.3572234957059665 1.0953194463192577 0.2733767109334721 1.0 0.8530847680373943 103 O43865,Q8TAD4,Q15043,P08133,O14936,Q8IYU8,P30536,P02786,O43707,P21796,Q9BPX6,O75844,Q96QD8,P50570,Q96GC9,O75027,Q9H2J7,O15173,P16615,Q9HD20,Q9H4A3,Q14BN4,P35670,P62942,Q6P4Q7,Q8WWC4,Q12959,Q9H4I9 28 +Regulation of lymphocyte activation 0.3653238294525355 1.09242786067038 0.2746450826311413 1.0 0.854295556349933 54 P14174,Q5RKV6,P30825,P12956,P04439,P00813,P49366,Q12959,P02786,O96005,Q96IZ0,Q9Y255,Q9NQT5,P98172 14 +Cartilage development involved in endochondral bone morphogenesis 0.6691006483547235 1.092256547524595 0.2747203537147968 1.0 0.854295556349933 4 P08133,O75844 2 +Response to bacterium 0.3564468118469414 1.0919732317276032 0.2748448671156962 1.0 0.854295556349933 57 Q5KU26,Q8WTV0,Q9UQB8,P30536,O43823,P08670,P51812,Q9BTY2 8 +Regulation of calcium ion import 0.8407677474705191 1.0889533466227694 0.2761744594937625 1.0 0.8554806153661219 3 P21796 1 +Response to retinoic acid 0.4697930769112086 1.088399053234948 0.276418978940633 1.0 0.8554806153661219 13 P11717,O94788 2 +Mitochondrial atp synthesis coupled proton transport 0.4959062752107785 1.0870129223797529 0.2770310987874476 1.0 0.8565458634656382 11 O75964,P00846 2 +Regulation of rig i signaling pathway 0.6117574461785081 1.0867027364070738 0.277168204288055 1.0 0.8565555815455891 5 Q9NUD5,Q14671 2 +Intrinsic apoptotic signaling pathway by p53 class mediator 0.44690739025241 1.085379044921803 0.2777538095478742 1.0 0.8579506561589892 16 P61978,P46379,P14174 3 +Antigen processing and presentation of exogenous peptide antigen 0.8395303326810055 1.0844565361476164 0.2781624281609773 1.0 0.8582980988794533 3 Q9UIQ6,P50570 2 +Regulation of sodium ion transmembrane transport 0.4507340012887754 1.0830011120106828 0.2788079294588024 1.0 0.8586731048150564 15 P50570,Q12959,O43707,Q9H4A3,Q14BN4 5 +Biomineralization 0.4951525749179504 1.082718252573056 0.2789334998126072 1.0 0.8586731048150564 11 Q6P4Q7,Q13586,O75844,O75116,Q13464 5 +Protein trimerization 0.6667378880118627 1.0825837773137652 0.2789932111718118 1.0 0.8586731048150564 4 Q99720 1 +Negative regulation of protein polymerization 0.4007818220378261 1.0793219225131203 0.2804442433946765 1.0 0.859204835776503 26 P35080,Q12792,P16949,P35611,P28289,Q9NYL9,Q13813,Q9UEY8,P45880,Q01082 10 +Modification of synaptic structure 0.552408981544589 1.0772511836890608 0.2813680645273446 1.0 0.8612974787752414 7 O00264,Q9UQB8 2 +Post translational protein modification 0.4940288397950051 1.0763154258324237 0.2817862120324497 1.0 0.862077052505016 11 P46977,Q9HA64,Q32P28,O60725 4 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.8392566025432177 1.0724537952893562 0.2835162565005618 1.0 0.8630203891595366 2 Q9UIQ6 1 +Response to gonadotropin 0.8389305510270619 1.0711889061569726 0.2840844987982953 1.0 0.8630203891595366 2 P16435 1 +Cellular response to follicle stimulating hormone stimulus 0.8389305510270619 1.0711889061569726 0.2840844987982953 1.0 0.8630203891595366 2 P16435 1 +Cellular response to gonadotropin stimulus 0.8389305510270619 1.0711889061569726 0.2840844987982953 1.0 0.8630203891595366 2 P16435 1 +Response to follicle stimulating hormone 0.8389305510270619 1.0711889061569726 0.2840844987982953 1.0 0.8630203891595366 2 P16435 1 +Tyrosine phosphorylation of stat protein 0.6081026190102146 1.070728598898407 0.2842914797035263 1.0 0.8630203891595366 5 Q9UIV1,Q92769 2 +Macromolecule deacylation 0.3975722074645347 1.0699630021227595 0.2846359625212304 1.0 0.8630203891595366 34 Q9NUJ1,P49354,Q96PK6,Q8N163,P50897,O43823,Q9UMR5,Q9ULX6 8 +Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process 0.663363318869844 1.0687778853913517 0.2851697664724488 1.0 0.8630841364876491 4 P49755,Q13492 2 +Regulation of aspartic type peptidase activity 0.663363318869844 1.0687778853913517 0.2851697664724488 1.0 0.8630841364876491 4 P49755,Q13492 2 +Transcytosis 0.5388223593010188 1.0685730411945362 0.2852621016046199 1.0 0.8630841364876491 8 Q07954 1 +Amino acid import 0.5383077026845691 1.065979314211348 0.2864329929560654 1.0 0.8642795784057615 8 P30825,P08195,Q15758 3 +Glial cell development 0.4393455090710325 1.0648635616461073 0.2869376765250389 1.0 0.8642795784057615 17 P08670 1 +Diol biosynthetic process 0.538073547643305 1.0647992762345893 0.2869667727487381 1.0 0.8642795784057615 8 P61457,P04062,Q13510 3 +Diol metabolic process 0.538073547643305 1.0647992762345893 0.2869667727487381 1.0 0.8642795784057615 8 P61457,P04062,Q13510 3 +Regulation of receptor mediated endocytosis 0.4234943364787484 1.0621614657436256 0.2881623900823504 1.0 0.8657001507904867 20 P61978,O00291,P41440,P50897 4 +Muscle hypertrophy in response to stress 0.8326209513958143 1.0593818657146543 0.2894259050161238 1.0 0.8680062085708705 3 P02545 1 +Response to molecule of bacterial origin 0.3936989529357251 1.0578548909406065 0.2901216032600557 1.0 0.8681487956568996 37 Q8WTV0,P08670,P30536,P51812,O43823 5 +Positive regulation of cell cell adhesion 0.3974063086965368 1.0555892761073766 0.2911559024260481 1.0 0.8681487956568996 31 P00813,P30825,P41440 3 +Terpenoid biosynthetic process 0.6041955667266203 1.0536639826506418 0.2920367844285967 1.0 0.8681487956568996 5 O94788 1 +Phosphatidylcholine acyl chain remodeling 0.8343658298011132 1.0535010211970737 0.2921114264990212 1.0 0.8681487956568996 2 Q96N66 1 +Negative regulation of response to wounding 0.5474693947685465 1.0531726963842685 0.2922618497178519 1.0 0.8681487956568996 7 Q96G23,O14936 2 +Response to angiotensin 0.604051606095686 1.0530354714773833 0.2923247352282303 1.0 0.8681487956568996 5 O75116,O43865,Q13464 3 +Neuron apoptotic process 0.3834943253761809 1.0501720831077463 0.2936390022331605 1.0 0.8693968920879203 44 Q15233,O95831,Q96A26,P09601,Q9NR28,P07196,P50897,Q01105,Q99720,O43813,P04062 11 +Selective autophagy 0.3971938016543233 1.049357687256264 0.2940135247944555 1.0 0.8693968920879203 27 P27544,Q9Y6I9,P21796,Q96HY6 4 +Negative regulation of proteasomal protein catabolic process 0.4156937553837458 1.047637257185951 0.2948057651020028 1.0 0.8698606654647929 21 P46379,Q9UL15,Q8N163,Q96HY6 4 +Endoplasmic reticulum organization 0.3886459524429106 1.0429100783158074 0.2969899414597736 1.0 0.8717513835164109 40 O14976,Q15629,Q96A33,Q9P2W9,Q8NHH9,P46379,O95197,O43681 8 +Golgi ribbon formation 0.656983644188671 1.0427100134034402 0.297082618811739 1.0 0.8717513835164109 4 Q08379 1 +Dna deamination 0.8267693464802485 1.0381947704123349 0.2991793868537726 1.0 0.8728731555947248 3 Q5RKV6 1 +Response to reactive oxygen species 0.3931609253038889 1.0381617424565484 0.2991947605182887 1.0 0.8728731555947248 35 O95831,O60658,P03915,P09601,P39210,Q99720 6 +Positive regulation of chromatin organization 0.5204484039750554 1.0371548934582442 0.2996636758335307 1.0 0.8728731555947248 9 P12270,Q8NEY8 2 +Fibroblast proliferation 0.4743671958542181 1.0352014970689885 0.3005748197922036 1.0 0.8728731555947248 12 O75844,P14174,Q96IZ0 3 +Regulation of platelet derived growth factor receptor signaling pathway 0.8257826946705362 1.0346270852429786 0.3008430998587532 1.0 0.8728731555947248 3 Q07954 1 +L amino acid transport 0.4738052780857382 1.0318831679299405 0.302126852020173 1.0 0.8741726331305173 12 Q96QD8,P30825,P08195,Q15758 4 +Regulation of production of molecular mediator of immune response 0.3948898325963711 1.0318161692020618 0.3021582431514757 1.0 0.8741726331305173 26 P14174,Q5RKV6,P09601,P04439,P02786,Q9NQT5 6 +Ventricular system development 0.5312047267495381 1.0301967064753543 0.3029176754965632 1.0 0.8741726331305173 8 Q7Z4L5,Q96N66 2 +G quadruplex dna unwinding 0.6535072401013093 1.0285249839990729 0.3037029446865831 1.0 0.8741726331305173 4 P22626 1 +Negative regulation of sister chromatid cohesion 0.8278447994783313 1.0283026461306672 0.3038074867294553 1.0 0.8741726331305173 2 P46100 1 +Regulation of cell cell adhesion mediated by integrin 0.8235485975211859 1.0265539493559088 0.3046305477074669 1.0 0.8741726331305173 3 P00813,Q9H4A3 2 +Regulation of cartilage development 0.652986804656207 1.0264027158686868 0.3047017984100064 1.0 0.8741726331305173 4 Q92896 1 +Regulation of chondrocyte differentiation 0.652986804656207 1.0264027158686868 0.3047017984100064 1.0 0.8741726331305173 4 Q92896 1 +T cell differentiation in thymus 0.530144770896722 1.024859797378781 0.3054293463839714 1.0 0.8741726331305173 8 P00813,O96005 2 +Positive regulation of neurogenesis 0.3864739238216685 1.0233059965797306 0.3061631893764938 1.0 0.8741726331305173 40 P30536,P07196,P55209,Q9UQB8 4 +Execution phase of apoptosis 0.5014368681914908 1.0217721529745052 0.3068887521525467 1.0 0.8744866622543942 10 O95831 1 +Regulation of mrna catabolic process 0.321425345245966 1.0199783175124213 0.3077387440803907 1.0 0.8746907839168566 69 P51114,P52272,O60506,P98175,Q9NQT5,Q5PRF9,P35637,Q13868,Q13464,Q969T7,Q9UIV1,Q9Y2W1,Q13151,Q15024,P08670,Q99729,Q92945,Q92804,Q14103,Q14671,Q14011,P27695,P67809 23 +Regulation of reactive oxygen species metabolic process 0.3931358156316993 1.0199086071950705 0.3077718070742317 1.0 0.8746907839168566 31 P30536,P42785,P00403,P39210 4 +Protein localization to synapse 0.4717215441951939 1.0195805470065789 0.3079274347155372 1.0 0.8746907839168566 12 Q14168,Q9UQB8 2 +Negative regulation of transforming growth factor beta receptor signaling pathway 0.5010328394432545 1.0195746894974012 0.3079302139175639 1.0 0.8746907839168566 10 P50570,Q92896 2 +Protein localization to golgi apparatus 0.50066841840492 1.0175927677453105 0.3088715257626546 1.0 0.8757980202777889 10 Q8TD16,O14976 2 +Protein localization to chromosome centromeric region 0.4836536965302131 1.017232583917854 0.3090427987848048 1.0 0.8758952373360115 11 Q96GD4,Q96DY7,O14777 3 +Exonucleolytic catabolism of deadenylated mrna 0.5157091572093009 1.0124511634394855 0.3113223858963014 1.0 0.8795731939627666 9 Q969T7,Q9UIV1,Q9NQT5,Q13868 4 +Cytokine production involved in immune response 0.4994010472946706 1.0107010326349517 0.3121595426713308 1.0 0.8806667269083989 10 P14174,P09601 2 +Production of sirna involved in rna interference 0.8186455174972862 1.008862696011859 0.3130404878307706 1.0 0.8814800859324259 3 Q15631 1 +Negative regulation of keratinocyte proliferation 0.6486612927143298 1.0087777943344056 0.3130812128796589 1.0 0.8814800859324259 4 Q9Y3B8 1 +Regulation of anion transport 0.4819226396977936 1.007383201833164 0.3137506605776887 1.0 0.8819554533553577 11 P14174,P08183 2 +Atp synthesis coupled proton transport 0.4696368460187655 1.0072767659959945 0.3138017917396682 1.0 0.8819554533553577 12 O75964,P00846 2 +Sulfur amino acid biosynthetic process 0.5928387158783383 1.0041480277160793 0.3153072686881084 1.0 0.8839222690863087 5 Q13126 1 +Cellular response to arsenic containing substance 0.5140509574056314 1.003811901852264 0.3154692865272062 1.0 0.8839222690863087 9 P09601 1 +Positive regulation of cell cycle g1 s phase transition 0.4342495209906459 1.0013219296122804 0.3166711941740303 1.0 0.8849631186838942 16 Q96DY7 1 +Positive regulation of amyloid precursor protein catabolic process 0.5651131514649559 0.999108481814451 0.3177421427849103 1.0 0.8867685744845043 6 Q96P70,Q13492 2 +Lens fiber cell development 0.819693511574846 0.9969304669756578 0.3187982619751512 1.0 0.8881626975263701 2 P08670 1 +Lens fiber cell differentiation 0.819693511574846 0.9969304669756578 0.3187982619751512 1.0 0.8881626975263701 2 P08670 1 +Pointed end actin filament capping 0.8196935115748287 0.9969304669755914 0.3187982619751834 1.0 0.8881626975263701 2 Q9NYL9 1 +Regulation of macroautophagy 0.3560697024853367 0.994664016621114 0.3198997009229609 1.0 0.8884451329569979 54 Q93050,Q9Y487,P09601,Q9UPT5,Q96CV9,O15118,P27544,Q8TBX8,P21796,P04062 10 +Embryonic organ development 0.3740536337547459 0.9941541759954208 0.3201478133802173 1.0 0.8884657633477039 46 P54802,O94788,Q8IZL8,Q9BVA1,P00813,Q12959,Q03164,P42892,O75569 9 +Cellular modified amino acid catabolic process 0.5637791214190354 0.9929931329025532 0.32071330102175 1.0 0.8888704791053393 6 Q9UHG3,Q9NRN7 2 +B cell activation 0.3878996772430617 0.9927845165165192 0.3208149770566357 1.0 0.8888704791053393 35 P14174,Q5RKV6,P00813,Q9UQ84,P02786,Q96IZ0 6 +T cell apoptotic process 0.5115506419037807 0.9907901012917484 0.3217880837960623 1.0 0.8906545089380024 9 P00813 1 +Positive regulation of histone ubiquitination 0.6430746921442645 0.9860540489804568 0.3241065908551184 1.0 0.8927137394626787 4 O75150 1 +Phosphatidylethanolamine metabolic process 0.8161069448973103 0.9831744274779362 0.3255215984528727 1.0 0.895344486130492 2 Q8NCC3 1 +Somatic diversification of immunoglobulins 0.4177812301442384 0.9830819985619416 0.3255670832426327 1.0 0.895344486130492 19 Q9UQ84,P02786,P20585,Q5RKV6 4 +Mitophagy 0.4385856696541666 0.9807295646574364 0.3267261204343561 1.0 0.8963702007545103 14 P27544,P21796 2 +Endoplasmic reticulum membrane organization 0.5322672479255233 0.9791804556686704 0.3274908237463045 1.0 0.8975466468212051 7 Q00765,Q9NQC3,Q9P2W9,Q8NHH9 4 +Negative regulation of nuclear division 0.4265103252704863 0.9779871499296772 0.3280806795945272 1.0 0.8976598878134361 17 P12270,Q96GD4,Q96DY7,O14777 4 +Positive regulation of amyloid beta clearance 0.8096988613625012 0.9766824416459234 0.3287263904103708 1.0 0.8978541393780054 3 Q07954 1 +Reactive oxygen species biosynthetic process 0.4929781213942455 0.975800049195309 0.3291635603833203 1.0 0.8986643061874252 10 O75027,P00403,Q15067 3 +Cellular response to biotic stimulus 0.3860298683292829 0.9712388473683468 0.3314293531188361 1.0 0.9011075493379608 34 P14174,Q8WTV0,O43823,P30536,O75844,P08670 6 +Ear development 0.4052962917497193 0.9709165172579268 0.3315898523131335 1.0 0.9011075493379608 21 P54802,Q8IZL8,P39210,P42892,O75569 5 +Folic acid metabolic process 0.5587892730348092 0.9701391509433954 0.3319771362821635 1.0 0.9011075493379608 6 P00374,P41440 2 +Phosphorylation of rna polymerase ii c terminal domain 0.6391517128874188 0.9701264529817588 0.3319834648331645 1.0 0.9011075493379608 4 Q14004,Q8WUA2,O60885 3 +Neural crest cell differentiation 0.4630324543518785 0.968335026413311 0.3328770771874043 1.0 0.9011075493379608 12 Q9UBV8,O94788,P08133,Q14978,P98172 5 +Mesenchymal cell development 0.4630324543518785 0.968335026413311 0.3328770771874043 1.0 0.9011075493379608 12 Q9UBV8,O94788,P08133,Q14978,P98172 5 +Zinc ion transport 0.807240704500966 0.9678652157431794 0.3331116883481506 1.0 0.9013610390597018 3 Q15043,Q8TAD4 2 +Snrna processing 0.4622397607420726 0.9636654824069888 0.3352136652317354 1.0 0.9043696943003025 12 Q9NQT5,Q5RKV6 2 +Histone h4 k20 methylation 0.8053564296682024 0.9611140302110934 0.3364948359601323 1.0 0.905914939422773 3 Q13610 1 +Base excision repair ap site formation 0.8095859145744979 0.9582437627991984 0.3379398543215397 1.0 0.906561510130072 2 P78549 1 +Fucose metabolic process 0.8079556569938224 0.9520280386540244 0.3410827621946355 1.0 0.9097893399171102 2 Q9BTY2 1 +Antigen processing and presentation of exogenous antigen 0.5546534034113589 0.9512230684903225 0.3414911504224374 1.0 0.9097893399171102 6 P50570,Q9UIQ6,Q06323 3 +Dna methylation involved in gamete generation 0.8066514509292484 0.9470605159932632 0.3436079429240097 1.0 0.912803402463127 2 Q8NB78 1 +Extracellular matrix disassembly 0.5144422347014748 0.9459290862181732 0.3441847569122509 1.0 0.912803402463127 8 P41440 1 +Inner cell mass cell proliferation 0.5783737437782533 0.9413289301227912 0.3465363216088171 1.0 0.9170886113653132 5 Q9BRT9,O75312,P61201 3 +Negative regulation of type i interferon mediated signaling pathway 0.6319778614556866 0.9410694922767894 0.3466692483062186 1.0 0.9170886113653132 4 Q9UIV1 1 +Purine nucleobase biosynthetic process 0.5132318570388923 0.9398581379526328 0.3472903326148142 1.0 0.9179720490860364 8 P00813 1 +Regulation of hormone levels 0.3138143205857582 0.9354638178407192 0.3495493215035137 1.0 0.9210063589131045 68 O94788,Q8TAD4,Q15043,P30536,O75844,P53985,P42892,Q9HB40 8 +Sterol biosynthetic process 0.3945299365758276 0.9341116716081364 0.3502462919332803 1.0 0.9215685347531029 22 P37268,P48449,Q15392,Q15800,Q16850 5 +Cellular response to inorganic substance 0.3810366181343909 0.9336957323088286 0.3504608670601055 1.0 0.9215685347531029 35 P50570,O95831,P25705,P35611,P09601,P30536,P46100,Q14168 8 +Nephron development 0.4310517011485024 0.9326799420171916 0.3509852441554235 1.0 0.9215685347531029 14 P57740,P39210,Q12959,Q12769,O00592 5 +Fatty acid transport 0.4275765046980453 0.9322943111023504 0.3511844469270444 1.0 0.9215685347531029 15 P23786,O43772 2 +Amine metabolic process 0.4275395275030594 0.9320544638483096 0.3513083793426945 1.0 0.9215685347531029 15 P49366,P21964 2 +Toxin transport 0.4442833360962268 0.931956348781302 0.3513590847496832 1.0 0.9215685347531029 13 Q93050 1 +Intrinsic apoptotic signaling pathway in response to oxidative stress 0.4233602322323098 0.9292105250570476 0.3527799939524567 1.0 0.9237283940295288 16 Q9UL15,P23246,Q9NR28,Q969S3 4 +Gmp biosynthetic process 0.456172382981427 0.9279627778544028 0.3534268779723919 1.0 0.9245236402843588 12 P00813,P55263 2 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.5749470142392624 0.9264986225127604 0.3541869126386354 1.0 0.9245236402843588 5 Q99729 1 +Negative regulation of gtpase activity 0.5105419386873172 0.9263746438125148 0.3542513166557208 1.0 0.9245236402843588 8 Q9H6U6,Q9H4A3,P36404 3 +Negative regulation of epithelial cell proliferation 0.4293384677968898 0.9217720025558388 0.3566475141177121 1.0 0.9261320907014275 14 P25705,Q9Y3B8,P57105,O14936,Q12959 5 +Cellular response to hydrogen peroxide 0.3981383620145465 0.9182421198491192 0.3584921219799706 1.0 0.9261320907014275 21 O95831,O60658,Q99720 3 +Negative regulation of receptor internalization 0.6262496422214293 0.917939135052357 0.3586507316177503 1.0 0.9261320907014275 4 Q13614 1 +Purine nucleobase metabolic process 0.4974323499844085 0.9174085225369972 0.3589286084722389 1.0 0.9261320907014275 9 P00813 1 +Positive regulation of rig i signaling pathway 0.7985001630257578 0.9161196361499166 0.3596041497796667 1.0 0.9263492120783104 2 Q9NUD5 1 +Positive regulation of cell division 0.4817435932339717 0.9148933319376386 0.3602476309696167 1.0 0.9263713306942608 10 Q96GD4,P67809 2 +Aminoglycan biosynthetic process 0.518780687727841 0.9137712145319078 0.3608370749026577 1.0 0.9263713306942608 7 P06865,Q7LGA3 2 +Ventricular cardiac muscle cell differentiation 0.7978480599934873 0.9136525684368654 0.3608994345885836 1.0 0.9263713306942608 2 P02545 1 +Ventricular cardiac muscle cell development 0.7978480599934873 0.9136525684368654 0.3608994345885836 1.0 0.9263713306942608 2 P02545 1 +Bone resorption 0.507739162702813 0.9123387574763184 0.3615904177245073 1.0 0.9270961882994676 8 O14773 1 +Lipoprotein catabolic process 0.5702134656632352 0.9060506411478554 0.3649090489489854 1.0 0.9310568471587444 5 P50897 1 +Protein depalmitoylation 0.5702134656632352 0.9060506411478554 0.3649090489489854 1.0 0.9310568471587444 5 P50897 1 +Semaphorin plexin signaling pathway 0.5445815585567457 0.9052776445507232 0.3653183166712148 1.0 0.9313577818164864 6 P42892 1 +Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.7952396478643609 0.903796956489994 0.3661030758808037 1.0 0.9326147678015376 2 Q9BRG1 1 +Inflammatory response 0.3102083609044136 0.9016108379603156 0.3672636317151796 1.0 0.9329765492761044 67 P00813,P42785,Q8IV08 3 +Negative regulation of dendritic spine development 0.6221859706362015 0.9015723326045352 0.3672840937722557 1.0 0.9329765492761044 4 Q92769,Q96EV8,Q8N5V2 3 +Purine deoxyribonucleoside monophosphate metabolic process 0.7885784750032203 0.9013158915416638 0.3674203867432239 1.0 0.9329765492761044 3 P00813 1 +Damp metabolic process 0.7885784750032203 0.9013158915416638 0.3674203867432239 1.0 0.9329765492761044 3 P00813 1 +Alcohol catabolic process 0.4791853751248011 0.9010564158517969 0.3675583246209739 1.0 0.9329765492761044 10 Q8WTV0 1 +Keratinocyte proliferation 0.5688581638018917 0.900204661750971 0.3680113457781853 1.0 0.93338538076387 5 Q9Y3B8 1 +Regulation of keratinocyte proliferation 0.5688581638018917 0.900204661750971 0.3680113457781853 1.0 0.93338538076387 5 Q9Y3B8 1 +Negative regulation of endothelial cell proliferation 0.5429141366074657 0.8976898980937296 0.369350896555066 1.0 0.9341889369355586 6 P57105,P25705 2 +Bergmann glial cell differentiation 0.5424777601239017 0.8957050883272213 0.3704102920864573 1.0 0.935019110778053 6 P08670 1 +Positive regulation of cell aging 0.5419064772165807 0.8931072849159752 0.3717997221320228 1.0 0.9369779003077462 6 P02545 1 +Reactive oxygen species metabolic process 0.3693742440476877 0.8912076834494522 0.3728177631785738 1.0 0.9374148976477824 42 O75027,P42785,P39210,P30536,Q13423,P00403 6 +Keratan sulfate metabolic process 0.7857142857142703 0.8911693613095143 0.3728383186663748 1.0 0.9374148976477824 3 O43505,P16278 2 +Branched chain amino acid transport 0.7910009781545488 0.8878259484821195 0.3746343826609779 1.0 0.938133736798435 2 Q9H2J7 1 +Leucine transport 0.7910009781545488 0.8878259484821195 0.3746343826609779 1.0 0.938133736798435 2 Q9H2J7 1 +Alanine transport 0.791000978154544 0.8878259484821001 0.3746343826609883 1.0 0.938133736798435 2 Q96QD8 1 +Nucleoside salvage 0.5656375330098649 0.8863291508629016 0.3754401850377018 1.0 0.938133736798435 5 Q13126 1 +Purine ribonucleoside salvage 0.5656375330098649 0.8863291508629016 0.3754401850377018 1.0 0.938133736798435 5 Q13126 1 +Receptor metabolic process 0.3754626195175943 0.8858313873803717 0.3757083935081695 1.0 0.938133736798435 35 P50570,P41440,P49354,Q07954,P02786,P42892 6 +Negative regulation of lipase activity 0.7839120415082548 0.8847948123633284 0.376267307890862 1.0 0.9381684608914872 3 P16435 1 +Positive regulation of nervous system development 0.3699230030387505 0.8847200161104467 0.3763076573743904 1.0 0.9381684608914872 41 P30536,P07196,P55209,Q9UQB8 4 +Adenylate cyclase activating g protein coupled receptor signaling pathway 0.565020546409765 0.8836736977385151 0.3768723827576672 1.0 0.9382785618163204 5 Q14344,Q9Y4G8 2 +Entry into host 0.3768713339174934 0.88328698882523 0.3770812318897973 1.0 0.9382785618163204 30 Q14108,Q8WTV0,Q9UPT5,Q9BTY2,O15118 5 +Forebrain regionalization 0.7896967720900001 0.8829231607920905 0.3772777889317735 1.0 0.9382785618163204 2 Q7Z4L5 1 +Smooth muscle cell migration 0.4757389235699602 0.8824380086487403 0.3775399892217439 1.0 0.9385655875131534 10 Q14344,O15511,Q07954,P46108,Q13685 5 +Protein oxidation 0.7829046557432012 0.8812351149418214 0.3781905769349181 1.0 0.9398170266444044 3 Q96JJ7 1 +Protein localization to lysosome 0.4228893616385462 0.8807872142699946 0.3784330013090682 1.0 0.9398170266444044 14 P20645,Q14108 2 +Neuromuscular process 0.3752028763744985 0.8804209339847651 0.3786313200869542 1.0 0.9398170266444044 24 Q8IZL8,P10253,P07196,O75844,O14773 5 +Histone h2a acetylation 0.4477294693101162 0.8784201916269716 0.3797157307123466 1.0 0.9417774950251142 12 O95619 1 +Magnesium ion homeostasis 0.7812738664411791 0.8754778613430024 0.3813139509321841 1.0 0.9429178197808072 3 Q6P4Q7 1 +Ribonucleotide catabolic process 0.4744351151199312 0.8754019261896991 0.38135525210403 1.0 0.9429178197808072 10 P00813 1 +Tooth mineralization 0.7870883599608874 0.8731340924399899 0.3825899933138053 1.0 0.943302448731703 2 Q6P4Q7 1 +Amelogenesis 0.7870883599608874 0.8731340924399899 0.3825899933138053 1.0 0.943302448731703 2 Q6P4Q7 1 +Enamel mineralization 0.7870883599608874 0.8731340924399899 0.3825899933138053 1.0 0.943302448731703 2 Q6P4Q7 1 +Positive regulation of receptor mediated endocytosis 0.4739785717631724 0.8729391647469097 0.3826962375814349 1.0 0.943302448731703 10 P61978,O00291,P50897 3 +Intermediate filament based process 0.4467483622333099 0.8726755852845625 0.3828399288711861 1.0 0.943302448731703 12 P07196,P08670,Q16352 3 +Positive regulation of macroautophagy 0.3858783324299546 0.869077858716215 0.3848045462767044 1.0 0.943336299041095 22 P27544,Q8TBX8,P09601,P21796 4 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.7783012165259064 0.8650005814367399 0.387038469657111 1.0 0.9463571606071004 3 P10321 1 +Regulation of superoxide metabolic process 0.5602811249568136 0.863306441146334 0.3879690036984877 1.0 0.9468738614762352 5 P00374 1 +Neuron projection arborization 0.5352306755112691 0.8628047930923901 0.3882448034133807 1.0 0.9468738614762352 6 Q13641,Q15334,Q13464 3 +Immune response regulating signaling pathway 0.3435078266642911 0.8623695073359627 0.3884842147332219 1.0 0.9468738614762352 54 P41440,Q9NPR9,P00813,P46379,P51812 5 +Retinol metabolic process 0.4976993176661767 0.8621907129901865 0.388582579373419 1.0 0.9468738614762352 8 O94788 1 +Protein localization to endoplasmic reticulum exit site 0.611745513866229 0.8597012203717419 0.3899537618974749 1.0 0.9491299404539224 4 P51572,Q92538,O15027 3 +Response to axon injury 0.4125758794964709 0.8581152635483733 0.3908288198486138 1.0 0.9491635638421736 16 Q96G23,P07196 2 +Sugar mediated signaling pathway 0.6099873034640104 0.8526774648407253 0.3938381911184874 1.0 0.9491635638421736 4 P17480 1 +Lipid export from cell 0.7736423541087117 0.8486263554894438 0.3960892368543303 1.0 0.9491635638421736 3 O15439 1 +Positive regulation of autophagy of mitochondrion 0.5051057431884012 0.8477966720438167 0.3965512168036955 1.0 0.9491635638421736 7 P21796 1 +Copi coated vesicle budding 0.6084828711256038 0.8466742338755403 0.3971767242349406 1.0 0.9491635638421736 4 P49755,Q9BVK6,Q92538 3 +Golgi vesicle budding 0.6084828711256038 0.8466742338755403 0.3971767242349406 1.0 0.9491635638421736 4 P49755,Q9BVK6,Q92538 3 +Export across plasma membrane 0.4530119731134366 0.8436359125233631 0.3988728898189819 1.0 0.9491635638421736 11 O15439,P08183 2 +Response to thyroid hormone 0.5305194653694274 0.841485533192202 0.4000759862171819 1.0 0.9491635638421736 6 P04062 1 +Positive regulation of fatty acid transport 0.7786110205412573 0.841478174397196 0.4000801070652731 1.0 0.9491635638421736 2 P14174 1 +Nucleoside metabolic process 0.40203133721175 0.8411322003774907 0.4002738776916752 1.0 0.9491635638421736 18 P00813,Q13126,P55263 3 +Embryonic pattern specification 0.52904615099466 0.8348305981310907 0.403813095228003 1.0 0.9491635638421736 6 Q9UK61,P98172 2 +Spindle midzone assembly 0.5280614711836145 0.8303861909142995 0.4063204705713188 1.0 0.9491635638421736 6 Q96GD4,Q9NQS7 2 +Sphingomyelin biosynthetic process 0.6039947270549229 0.828803138968516 0.4072158117356745 1.0 0.9491635638421736 4 O15269,P22059 2 +Purine nucleotide catabolic process 0.43918887128558 0.8285167142117952 0.4073779332077261 1.0 0.9491635638421736 12 P00813 1 +Atp biosynthetic process 0.3954383669575111 0.8263592272571014 0.408600345121934 1.0 0.9491635638421736 19 O75964,P00403,P00846 3 +Regulation of membrane protein ectodomain proteolysis 0.6033213490450304 0.8261269485662441 0.4087320821509277 1.0 0.9491635638421736 4 O43847 1 +Negative regulation of hydrolase activity 0.3234438374484653 0.8255514154088466 0.4090586051237661 1.0 0.9491635638421736 60 P78318,Q99523,P62942,Q15043,Q9H6U6,Q9Y3B8,Q07954,P36404,P51812,Q15418,Q9H4A3,Q9UII2,Q96K76,Q15392,Q13464,P16435 16 +Tissue migration 0.3466828847574722 0.8232866905609578 0.4103449804811934 1.0 0.9491635638421736 51 P25705,P57105,P42785,P09601,Q8WTV0 5 +Negative regulation of defense response 0.3694520687921911 0.8223320670339999 0.4108879309229696 1.0 0.9491635638421736 30 P28070,P04062,Q9UIV1,P46108,P04439,P00813,P19474,O43657,Q07021 9 +Xenobiotic metabolic process 0.4377788472182536 0.820302351708077 0.4120437660795542 1.0 0.9491635638421736 12 P07099 1 +Import into cell 0.3689260704402891 0.8182115849404316 0.4132363811932915 1.0 0.9491635638421736 29 P08195,P41440,Q15043,P33121,Q99808,P30825,Q15758,Q12959,Q9H4A3,Q8TDW0 10 +Inner ear receptor cell development 0.5253609274095501 0.8182114651496449 0.4132364495828646 1.0 0.9491635638421736 6 P54802 1 +Synaptic transmission gabaergic 0.5497064916117255 0.8180786273090606 0.413312291954528 1.0 0.9491635638421736 5 P33176,Q13641,P51790 3 +Multi multicellular organism process 0.3682286956390498 0.8180071371462415 0.4133531119246725 1.0 0.9491635638421736 26 Q96GC9,P41440,Q8IZL8,Q96QD8,P07686,Q9UIQ6,Q7Z7E8,Q07021 8 +Oligosaccharide metabolic process 0.5493839860013225 0.8167043785356608 0.414097388502209 1.0 0.9491635638421736 5 P10253,P06280,P07686 3 +Response to dsrna 0.4024524835382556 0.8162422459285743 0.41436159901645 1.0 0.9491635638421736 17 Q5KU26,P41440 2 +Humoral immune response mediated by circulating immunoglobulin 0.7714378871861945 0.8148936528710016 0.4151331866318408 1.0 0.9491635638421736 2 Q9UQ84 1 +Positive regulation of epithelial cell migration 0.368450261583693 0.8143441805332231 0.4154478064820404 1.0 0.9491635638421736 29 P09601,Q8WTV0,P25705 3 +Regulation of receptor catabolic process 0.6003262642740586 0.8142403805421617 0.4155072566573952 1.0 0.9491635638421736 4 Q96J02,Q13614,P18031 3 +Tumor necrosis factor superfamily cytokine production 0.4016233141527929 0.8107086454974569 0.4175330072964631 1.0 0.9491635638421736 17 P30536,O43823 2 +Regulation of amyloid fibril formation 0.5468193249814902 0.8057875164861577 0.4203653772349143 1.0 0.9501949186574902 5 Q9UHV9 1 +Negative regulation of amyloid fibril formation 0.5468193249814902 0.8057875164861577 0.4203653772349143 1.0 0.9501949186574902 5 Q9UHV9 1 +Cellular response to estradiol stimulus 0.5468166154854768 0.8057759941535994 0.4203720221614899 1.0 0.9501949186574902 5 O95831 1 +Negative regulation of peptidase activity 0.3660896240747427 0.8057101736809841 0.4204099819959399 1.0 0.9501949186574902 35 P51812,Q15392,Q15418,Q07954 4 +Extracellular matrix assembly 0.5465451677673063 0.8046217625065899 0.4210379798727404 1.0 0.950893305004268 5 P07942 1 +Response to salt 0.5973679728341496 0.8025274634026544 0.422247908587102 1.0 0.95193994565412 4 P07196 1 +Mitochondrial fusion 0.4104446805710773 0.8021289599075192 0.4224783645132328 1.0 0.95193994565412 14 Q9NX63,Q8IWA4,Q9Y4W6,Q8TB36,P02786,Q99536,Q9Y6C9 7 +Regulation of t cell activation 0.3642836203763849 0.8007672792768368 0.42326638496945 1.0 0.95193994565412 37 P30825,P04439,P00813,P49366,Q12959,P02786,O96005,Q96IZ0,Q9Y255 9 +Amine catabolic process 0.7588372900974973 0.7969968603751352 0.425452854730882 1.0 0.955848753741834 3 P21964 1 +Protein targeting to membrane 0.3660698671492687 0.7964075321960072 0.4257952016669957 1.0 0.9559461093605232 32 O60725,Q15629,P43307,P56589,P46379,O43681 6 +Polyamine metabolic process 0.5954471421442749 0.7949374460796634 0.426649890547218 1.0 0.9571927719855832 4 P49366 1 +Gtp biosynthetic process 0.7577237854080155 0.793140436970359 0.4276960056016503 1.0 0.9575239004961318 3 P22392 1 +Ectoderm development 0.5947683625781301 0.7922582377477629 0.4282101172322547 1.0 0.9577033798277388 4 Q8N1B4,P13693 2 +Blastocyst growth 0.4831898022239973 0.7901733766149179 0.4294265220079927 1.0 0.9597528975201824 8 Q9BRX2,O75312,Q6PD62,Q9BRT9,P61201 5 +Negative regulation of cellular catabolic process 0.3216151815562808 0.7881848410332177 0.4305885947202337 1.0 0.9610798375357614 90 P85037,Q92804,P35637,Q9UL15,Q96JB5,P09601,Q14011,Q8N163,P30536,P46379,O60506,P98175,Q96HY6,Q99729,O15118,P10619,Q08J23,P67809 18 +Negative regulation of insulin secretion involved in cellular response to glucose stimulus 0.7639387023149606 0.787313244311504 0.4310985184678511 1.0 0.961497270486996 2 Q8N5M9 1 +Negative regulation of dna binding transcription factor activity 0.3638942941243137 0.787152858661354 0.4311923895089171 1.0 0.961497270486996 25 O75381,P09525,P09601,Q00577,Q96JB5 5 +Positive regulation of stem cell differentiation 0.5932922715280867 0.7864373546044378 0.4316113064371714 1.0 0.961497270486996 4 Q9Y6C9,Q13610 2 +Regulation of amyloid precursor protein catabolic process 0.4047986206260096 0.7854507738159455 0.4321893214326029 1.0 0.961497270486996 15 P62942,Q9NQC3,P27695,Q96P70,O95197,P49755,Q13464,Q13492 8 +Autophagy of mitochondrion 0.3648716315715731 0.785251631338341 0.4323060487889045 1.0 0.961497270486996 31 Q7Z3C6,P30536,P27544,P21796,P04062 5 +Positive regulation of mrna splicing via spliceosome 0.397638125655852 0.7841637516608048 0.4329440316239461 1.0 0.961497270486996 17 P62995,Q9Y2W1,Q14011,P38159,Q96E39,Q96EP5,P98179 7 +Termination of rna polymerase ii transcription 0.7629605477665657 0.7837326158964597 0.433197020192956 1.0 0.961497270486996 2 O95104 1 +Nuclear ncrna surveillance 0.5414882804800705 0.7831638355531955 0.4335309087916812 1.0 0.961497270486996 5 Q9NQT5,Q13868 2 +Peptidyl methionine modification 0.7545317108768101 0.7821072720597431 0.4341515333713084 1.0 0.9615682359412848 3 Q5VZE5 1 +Positive regulation of leukocyte cell cell adhesion 0.362695873641571 0.7820852907849968 0.4341644506040802 1.0 0.9615682359412848 24 P00813,P30825 2 +Antigen processing and presentation 0.3683061043597344 0.779639985904778 0.4356028128407465 1.0 0.9636910799092594 23 P50570,Q03519,P10321,Q06323,Q9UIQ6,P04062 6 +Regulation of leukocyte migration 0.3632839362545877 0.7787384703865344 0.4361337894467181 1.0 0.9636910799092594 26 P00813 1 +Zinc ion homeostasis 0.5165419247430805 0.7786110813321835 0.4362088494072318 1.0 0.9636910799092594 6 P35670,Q8TAD4 2 +Cation transport 0.3731666671600106 0.7782854413144422 0.4364007563015568 1.0 0.9636910799092594 159 O43865,Q9UDW1,O43772,Q8TAD4,Q15043,P25705,P08133,O14936,P00846,P30536,Q8IYU8,P02786,O43707,P51790,P21796,Q9BPX6,O75844,Q96QD8,Q70HW3,P50570,Q96GC9,P30825,O75964,O75027,Q9H2J7,O15173,P16615,Q13423,Q9HD20,P00403,Q9H4A3,Q14BN4,P35670,P62942,P03915,Q6P4Q7,Q8WWC4,Q12959,Q96ES6,Q9H4I9 40 +Positive regulation of sodium ion transmembrane transport 0.4905577710437776 0.7781519952058193 0.4364794131087293 1.0 0.9636910799092594 7 P50570,O43707 2 +Regulation of er to golgi vesicle mediated transport 0.4904457927381323 0.7776185646779284 0.4367939133146983 1.0 0.964052565320739 7 Q6NUQ1 1 +Embryonic brain development 0.5394178241023763 0.7744036349464203 0.43869213475462 1.0 0.9667339797683514 5 Q9BVA1 1 +Negative regulation of receptor binding 0.7597000326051462 0.7718262411328338 0.4402173475235089 1.0 0.9667339797683514 2 P16615 1 +Intermembrane lipid transfer 0.5386897350075353 0.7713266997851408 0.4405133103591254 1.0 0.9667339797683514 5 P30536 1 +Glycosylceramide metabolic process 0.5877516209523356 0.7646562131443061 0.4444762863869171 1.0 0.9667339797683514 4 P04062 1 +I kappab phosphorylation 0.7574176719921963 0.7635189047536225 0.4451539922848297 1.0 0.9667339797683514 2 Q96HY6 1 +Negative regulation of mrna 3 end processing 0.513095273581136 0.7632061073058419 0.4453404870812041 1.0 0.9667339797683514 6 P18615,Q5VTR2,O75150 3 +Positive regulation of neuron projection development 0.361620472228348 0.7626206599272861 0.4456896597422184 1.0 0.9667339797683514 27 Q14108,O15031,Q9UQB8 3 +Cerebellar cortex development 0.4277243822538906 0.761968521377559 0.4460787919522402 1.0 0.966931483530436 12 Q5KU26,Q7Z4L5,P54802,P04062 4 +Pyridine containing compound catabolic process 0.5865342670066016 0.7598855322308815 0.4473230103664418 1.0 0.966931483530436 4 Q13126 1 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.4376220195292206 0.7574486167442848 0.44878113887812 1.0 0.9691005072565684 11 P61978,P14174,Q8N163 3 +Glutamine transport 0.7554613628953333 0.7564165151469842 0.4493995092355949 1.0 0.9694168327315412 2 Q96QD8 1 +Cell cycle dna replication 0.3893809035797504 0.755119209383778 0.4501774582512836 1.0 0.9694168327315412 18 Q14566,P33991,P46100 3 +Cytoplasm organization 0.7548092598630561 0.7540528367123059 0.4508174957302331 1.0 0.9694168327315412 2 Q9Y2W6 1 +Response to manganese ion 0.5848923434128147 0.7534598260565697 0.4511736438480171 1.0 0.9694168327315412 4 P30536 1 +Positive regulation of sodium ion transport 0.4655018840750026 0.7530733872820258 0.4514058154587843 1.0 0.9694168327315412 9 P50570,O43865,O43707 3 +Demethylation 0.3963108821320482 0.7518342042114219 0.4521507697703106 1.0 0.9694168327315412 16 Q93009,O75151,Q8IUF8,P27695,Q8NB78,P29375,P16435,Q16850 8 +Protein localization to cilium 0.4023943448424456 0.7516375548598278 0.4522690524596728 1.0 0.9694168327315412 14 Q7Z4L5,Q9Y5K8,A0AVF1,Q9UPT5,Q10713 5 +Quaternary ammonium group transport 0.745660830956529 0.751624479164261 0.4522769179844803 1.0 0.9694168327315412 3 O43772 1 +Negative regulation of glycoprotein metabolic process 0.7455968688845214 0.7514056791217788 0.4524085459439242 1.0 0.9694168327315412 3 O14734,Q9NQX7 2 +Positive regulation of synaptic transmission gabaergic 0.7538311053146419 0.7505109050962093 0.452947058415172 1.0 0.9694168327315412 2 P33176 1 +Ncrna catabolic process 0.3640159714518355 0.7470226169337068 0.4550499087178405 1.0 0.9701864342587104 23 Q9NQT5,Q08J23,Q13868,Q5RKV6 4 +Regulation of cell cell adhesion 0.3429221111476471 0.7462808347702702 0.4554977862624567 1.0 0.9704941170816888 49 P41440,P30825,P04439,P00813,P49366,Q12959,P02786,Q96IZ0,Q9H4A3,P98172 10 +Mitochondrial proton transporting atp synthase complex assembly 0.7435806132122114 0.744516039480699 0.4565643413124871 1.0 0.9718313747111318 3 Q15070 1 +Apoptotic mitochondrial changes 0.3596808235881021 0.7435338978764502 0.4571585066046033 1.0 0.9718789038090736 32 P02545,Q9Y3B8,Q96A26,Q8N163,P48507,Q9Y255,Q3ZCQ8,P45880 8 +Nucleoside triphosphate metabolic process 0.350634888064334 0.7434459710649 0.4572117207784945 1.0 0.9718789038090736 44 P25705,O75964,P00846,P00813,P00403,P55263,Q9H773 7 +Bone development 0.3736458176257827 0.7396938643271096 0.4594857719340122 1.0 0.9744451163336896 21 Q32P28,Q7Z3C6,P08133,Q15904,O75844,Q92896,P16435 7 +Glycosylceramide catabolic process 0.7419355717885147 0.7389057826415728 0.4599642107169925 1.0 0.9751363273622184 3 P04062 1 +Regulation of retrograde transport endosome to golgi 0.7499184871209668 0.7363869185128107 0.4614952633816296 1.0 0.9780579098648128 2 P53367 1 +Ion transport 0.3997232359750671 0.7340182635683828 0.4629376071033677 1.0 0.9793696859457108 210 P14174,O43865,Q9UDW1,O43772,Q8TAD4,Q15043,P25705,P08133,O15439,O14936,P00846,P30536,Q8IYU8,P02786,O43707,Q8TDW0,P45880,P21796,P51790,Q9BPX6,P07602,Q9Y277,Q9UHG3,O75844,Q96QD8,P08183,P53985,Q6N075,Q70HW3,P50570,Q96GC9,P41440,P30825,O75964,O75027,Q9H2J7,O15173,P16615,Q13423,Q9HD20,P00403,Q9H4A3,Q14BN4,Q9C0H2,P35670,P62942,P03915,Q6P4Q7,Q8WWC4,Q12959,Q9BQT8,Q9H0H5,Q96ES6,Q9H4I9,Q9UBX3,O43681 56 +Response to activity 0.432978083756191 0.7316429160214324 0.4643865466825541 1.0 0.979835367674321 11 O43819,Q9UDX5,P25705,P06493,P48507 5 +Negative regulation of t cell proliferation 0.4806680078098555 0.7312216453705247 0.4646437810375921 1.0 0.979835367674321 7 Q96IZ0 1 +Mitochondrion organization 0.3860825100418649 0.7298545708406255 0.4654790835949476 1.0 0.980973388433123 186 Q8N4H5,Q99595,P02545,Q9BUK6,Q16891,P39210,P30536,Q15070,O96000,P02786,Q9NS69,O14737,Q9Y255,Q9Y584,P27544,Q96CV9,O60830,P45880,P21796,Q10713,Q5HYI7,Q99536,Q9NX63,O75153,Q9H061,Q8IWA4,Q8N4Q1,O43674,Q96CU9,Q9UG56,P55786,Q5XKP0,Q9Y2R0,O14925,O95831,Q7Z3C6,P62072,Q9Y3B8,Q96A26,Q8N163,O75431,O43676,Q9Y6C9,Q3ZCQ8,Q9UDX5,Q69YU5,P03915,O96008,O75306,O00165,Q8WWC4,Q5JRX3,P48507,Q13505,Q9UII2,Q5TC12,Q6DKK2,P04062 58 +Dna modification 0.3573202969695914 0.7284563799609033 0.4663342612292189 1.0 0.9810143166388804 27 Q5RKV6,Q86YP4,P29372,O75844,Q9Y2W6,P46100,Q8NB78,Q9NQT5,P78549,Q03164 10 +Positive regulation of anion transport 0.4789755602333821 0.7232298212663485 0.4695387003494449 1.0 0.9826992606937296 7 P08183 1 +Ensheathment of neurons 0.3569107518278023 0.7227628156552173 0.469825615944216 1.0 0.9826992606937296 28 Q9NR77,O75312,Q96PU8,Q12959,P07686,O15121,Q13614,Q15149 8 +Mitotic dna replication 0.459262698916487 0.7213681724409441 0.4706830233750945 1.0 0.9826992606937296 9 Q14566,P33991 2 +Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.4691535924197622 0.7211895996483937 0.4707928698107015 1.0 0.9826992606937296 8 P14174,Q8N163 2 +Response to iron ion 0.503432414419484 0.7202599820242199 0.4713649389533241 1.0 0.9826992606937296 6 P09601,P02786 2 +Response to epidermal growth factor 0.3945570197926363 0.7202509842823589 0.4713704778665248 1.0 0.9826992606937296 15 O60658,Q9UQB8 2 +Protein targeting to vacuole 0.3972510712399839 0.7195794448129683 0.4717839716466852 1.0 0.9826992606937296 14 P20645,Q14108 2 +Negative regulation of catabolic process 0.3226646485238064 0.7178837718054313 0.4728289547786946 1.0 0.9831766949121864 98 P30536,P46379,O60506,P98175,Q96HY6,P85037,Q08J23,Q16850,P35637,Q9UL15,P09601,Q8N163,Q99729,P10619,Q92804,Q14011,O15118,Q96JB5,P67809 19 +Oxidative phosphorylation 0.3167248995167382 0.7167329035383645 0.4735389192626842 1.0 0.9843328510291296 59 Q9UDW1,P25705,O75964,P03915,P00846,O43676,O96000,P00403 8 +Response to cold 0.4302014734512413 0.7162663176317238 0.4738269205505026 1.0 0.9845804117010782 11 P00403 1 +Regulation of histone h2b ubiquitination 0.7352001945541602 0.7160410777621943 0.4739659848632966 1.0 0.9845804117010782 3 O75150 1 +Mrna modification 0.4298491123989814 0.7143179485068909 0.4750305960943295 1.0 0.9846446453437754 11 Q08J23,Q96FX7 2 +Glycoprotein metabolic process 0.3242540094799147 0.7117410454275758 0.4766251456731649 1.0 0.9846446453437754 56 O14734,Q08379,P35610,Q7LGA3,Q2TAA5,Q99805,Q9Y5P6,Q10472,P04843,Q86SF2,Q8NAT1,Q96IZ0,Q9BT22,Q8TCJ2,O60502,Q9NQX7,P46977,O43505,P04844,O95394,O15118 21 +Alcohol biosynthetic process 0.355556824726602 0.7110209371038109 0.4770712615936645 1.0 0.9846446453437754 33 P37268,Q15800,Q13510,P00374,P61457,Q15392,P48449,P04062,Q16850 9 +Glomerulus development 0.5733185058164014 0.7084701333828285 0.4786533529967969 1.0 0.9846446453437754 4 P39210 1 +Glyoxylate metabolic process 0.7307508420515441 0.7010335413833856 0.4832820832666398 1.0 0.9861638525615178 3 P48735 1 +Positive regulation of nf kappab transcription factor activity 0.357802533580476 0.7000531108168573 0.4838941369397731 1.0 0.9864931043396534 23 P02786,P41440,Q96HY6 3 +Glycine biosynthetic process 0.7388327355722162 0.6967670610903599 0.4859485829807006 1.0 0.9868581227967366 2 P00374 1 +Glycerolipid biosynthetic process 0.3520426881962747 0.6953442562997423 0.4868395855142673 1.0 0.9869538077927156 37 Q9NUQ2,P33121,Q8WTV0,O00459,Q8NCC3,Q96N66,Q9NPH0,Q9BTU6,Q9UG56,Q8TBX8,Q13614,Q8NF37,Q10713 13 +Negative regulation of cell substrate adhesion 0.4637842078008063 0.6950221207997486 0.4870414387902113 1.0 0.987050066442032 8 Q9H6U6,O14936 2 +Regulation of autophagy 0.3182147325017579 0.6940070936975015 0.487677760296175 1.0 0.9874007597636932 95 P07602,P85037,P27544,Q93050,Q08379,Q9Y487,P09601,O00459,Q9UPT5,P30536,O75844,Q96CV9,O15118,P10619,Q8TBX8,P21796,P04062 17 +Aging 0.2932593692932194 0.6890868366038823 0.490768623180402 1.0 0.98969496883482 67 P14174,Q96GD4,P02545,P25705,P00846,P30536,O75844,Q96IZ0,P46100,P04062,P67809 11 +Pyrimidine nucleotide catabolic process 0.7270179374258249 0.6885045744117261 0.4911350906384477 1.0 0.98969496883482 3 Q9H773 1 +Cell cell recognition 0.4039473729969953 0.688443120474429 0.491173777437617 1.0 0.98969496883482 13 Q12959,P45880,P78371 3 +Lipid homeostasis 0.3664562599439944 0.6880420090887571 0.4914263273465513 1.0 0.98969496883482 21 O15118,O15254,Q8WTV0 3 +Transepithelial transport 0.5674509198640717 0.6858816282109349 0.4927877562506912 1.0 0.98969496883482 4 P08183 1 +Cysteine metabolic process 0.5674256502219678 0.6857846893276466 0.4928488925506462 1.0 0.98969496883482 4 P25325,P32929 2 +Positive regulation of immunoglobulin production 0.4033370885295437 0.6848249013686332 0.4934544198694723 1.0 0.98969496883482 13 Q9NQT5,P02786,Q5RKV6 3 +Regulation of mitochondrion organization 0.3453924055465379 0.6839484109724956 0.49400774282089 1.0 0.9901630311447986 43 P02545,Q9UII2,Q96A26,P30536,O00165,P02786,O14737,Q9UG56,Q9Y255,Q99536,P27544,Q9Y6C9,P21796 13 +Regulation of oxidative stress induced cell death 0.3704668927376615 0.683646313170046 0.4941985321906204 1.0 0.9901630311447986 20 O60658,Q9UL15,Q96IZ0,P23246,O43813 5 +Autophagosome organization 0.3517073036916698 0.6813933344069171 0.4956226394244543 1.0 0.9903295592474708 28 Q96GC9,Q7Z3C6,P16615,P56962,Q8TBX8,Q86Y82,P04062 7 +Fatty acid beta oxidation using acyl coa oxidase 0.51651901620683 0.6786579986268142 0.4973545847216976 1.0 0.9918417567528724 5 O15254 1 +Protein geranylgeranylation 0.5648128073213954 0.675777691540931 0.4991818004912189 1.0 0.9928768053228458 4 P49354 1 +Cardiac cell development 0.4227393260237519 0.6751578850722306 0.4995754604761027 1.0 0.9929392273186822 11 O75844,P06493,Q15149,P02545 4 +Negative regulation of organelle assembly 0.4921502927543171 0.670630975021515 0.5024556448818034 1.0 0.9942011324002328 6 Q96PK6 1 +Production of molecular mediator of immune response 0.3503057731801278 0.6695922094798757 0.503117781666151 1.0 0.9942011324002328 34 P14174,Q5RKV6,P09601,Q9UQ84,P02786,P20585,Q9NQT5 7 +Negative regulation of intrinsic apoptotic signaling pathway 0.3505382360895657 0.668266175471517 0.5039637003971533 1.0 0.9942011324002328 31 P14174,Q9UL15,Q8N163,P45880,Q15233 5 +Motor behavior 0.7306814476687373 0.6680355856628267 0.5041108774434475 1.0 0.9942011324002328 2 P04062 1 +Positive regulation of production of molecular mediator of immune response 0.3587272836220512 0.6678128040591933 0.5042530923324922 1.0 0.9942011324002328 22 P14174,Q5RKV6,P04439,P02786,Q9NQT5 5 +Regulation of reactive oxygen species biosynthetic process 0.4572190105152338 0.6632209078242567 0.5071890828381762 1.0 0.9959492834496554 8 O75027,P00403 2 +Cellular response to acid chemical 0.4101013189429939 0.661006063994717 0.5086084247099751 1.0 0.9978650713702304 12 Q9P2J5,Q14103,P48507,Q9UQB8,Q99729 5 +Regulation of alternative mrna splicing via spliceosome 0.3489957000796776 0.6564242619439354 0.5115511840753704 1.0 1.0 30 O75525,P51114,Q9BWF3,P62995,Q9Y5S9,Q92841,Q96T37,Q9Y2W1,P17844,P38159,P98175,Q07666,Q9UHX1,Q8IY67 14 +Negative regulation of cell aging 0.5593682749348047 0.6550326456828758 0.5124467356627171 1.0 1.0 4 P67809 1 +Maternal process involved in female pregnancy 0.4882464953575832 0.6536040695019755 0.5133669217254824 1.0 1.0 6 P35613,Q8IZL8,Q96EP5 3 +Negative regulation of protein containing complex disassembly 0.3483916159846714 0.6530126588582225 0.5137481175943175 1.0 1.0 29 Q12792,P35611,P29372,P28289,O15344,Q9NYL9,Q13813,O95104,Q01082 9 +Gliogenesis 0.333221235341153 0.6521346724090872 0.5143142984692122 1.0 1.0 49 Q7Z4L5,Q96G23,Q07954,P07942,P08670,P30536,Q96N66 7 +Regulation of cell activation 0.2900959457561426 0.6498784432221324 0.5157707436723471 1.0 1.0 67 P14174,Q5RKV6,P30825,P12956,P09601,P04439,P00813,P49366,O95219,P02786,Q15418,Q12959,Q96IZ0,Q9Y255,O96005,Q9NQT5 16 +Hydrogen peroxide biosynthetic process 0.7153008217568798 0.6495666420833225 0.5159721862895719 1.0 1.0 3 P00403 1 +Prenylation 0.5089858413882701 0.6476900994037968 0.5171854090584116 1.0 1.0 5 P49354 1 +Regulation of cholesterol biosynthetic process 0.5573087817840462 0.647224599251088 0.5174865928125305 1.0 1.0 4 P16435 1 +Regulation of alcohol biosynthetic process 0.5573087817840462 0.647224599251088 0.5174865928125305 1.0 1.0 4 P16435 1 +Isoprenoid biosynthetic process 0.4622993965029671 0.6452083879884949 0.5187921511682609 1.0 1.0 7 O94788 1 +Muscle cell apoptotic process 0.3965550110690467 0.6448014391676449 0.5190558691824698 1.0 1.0 13 P09601 1 +Sensory organ development 0.3224798038215125 0.6437507439984781 0.5197370788014393 1.0 1.0 54 P54802,O94788,Q8IZL8,P28289,P39210,P08670,Q12959,Q9Y6M7,P42892,Q15293,Q8NF37,O75569,P48681 13 +Establishment of protein localization to vacuole 0.3793466134604175 0.6427989137754515 0.5203545880551879 1.0 1.0 16 P20645,Q99523,Q9BRG1,Q14108,Q9Y2T2 5 +Amyloid fibril formation 0.4529713976720438 0.6427703232633267 0.5203731422803253 1.0 1.0 8 O15212,Q9UHV9 2 +Mitochondrial protein catabolic process 0.7228562112813778 0.6407972542914768 0.5216544170811712 1.0 1.0 2 Q9UG56 1 +Regulation of cellular response to transforming growth factor beta stimulus 0.3957793672792046 0.6402470104717729 0.5220120245136526 1.0 1.0 13 P50570,Q92896 2 +Positive regulation of dna methylation dependent heterochromatin assembly 0.4851309315663373 0.640073596116352 0.522124753872155 1.0 1.0 6 Q8NEY8 1 +Positive regulation of receptor clustering 0.722530159765244 0.6396699543286426 0.5223871928315988 1.0 1.0 2 Q14696 1 +Maintenance of postsynaptic specialization structure 0.7225301597652402 0.6396699543286283 0.5223871928316082 1.0 1.0 2 Q12959 1 +Molting cycle 0.4429475757669284 0.639359707015573 0.5225889548344718 1.0 1.0 9 Q08J23 1 +Striated muscle cell differentiation 0.3448472108290557 0.6391183066513579 0.5227459715407989 1.0 1.0 38 P35579,Q99523,P41440,P02545,Q8IV08,P28289,Q9NYL9,O75844,P67809 9 +Positive regulation of peptidyl tyrosine phosphorylation 0.3814340493578499 0.637802428036934 0.5236022988328868 1.0 1.0 15 P14174,P22059,Q92796,Q92769,O00165,Q15334,Q9H223 7 +Meiotic spindle organization 0.4846030004311118 0.6377861823742791 0.523612875430828 1.0 1.0 6 Q08379,P46100,O14777 3 +Establishment of protein localization to membrane 0.3083199042234866 0.6350391255862281 0.5254028976036993 1.0 1.0 89 P40855,O60725,Q15629,P62072,P43307,P56589,Q8WWC4,P46379,Q96A33,Q15070,Q9NS69,Q9HD20,Q96CV9,O15118,Q9Y584,O43681 16 +Cytosolic calcium ion transport 0.3449879011541289 0.6315004480215798 0.5277133563850067 1.0 1.0 27 P62942,Q8IYU8,Q8WWC4,Q9H4I9,P21796,Q9BPX6 6 +Golgi organization 0.3165030063483801 0.6296748197777277 0.5289073603702554 1.0 1.0 56 P50570,Q96GC9,O14976,Q08379,Q9H6U6,Q9UL15,Q8TBA6,Q9P2W9,Q8NHH9,P56962,Q5VU43,O15260 12 +Mrna transport 0.2956021487096333 0.6288106338278985 0.5294730374524872 1.0 1.0 75 Q8TD16,Q99567,Q7Z3B4,Q08J23,P12270,P41208,Q8NFH5,Q9BTX1,P51991,Q96PU8,Q53F19,Q8NFH4,Q07955,P22626,Q8N1F7,Q92945,Q16629,Q9ULX6,Q9Y6M1 19 +Intraciliary transport involved in cilium assembly 0.7192696446038551 0.6284315316096848 0.5297212864549603 1.0 1.0 2 A0AVF1 1 +Mrna 3 end processing by stem loop binding and cleavage 0.7189435930877035 0.6273111817400071 0.5304552751998473 1.0 1.0 2 Q9UKF6 1 +Regulation of circadian rhythm 0.3424214819852703 0.625359436554182 0.5317351785028883 1.0 1.0 24 Q14103,Q9BWF3,Q9Y2W1,Q16531,Q8N163,P06493,P29992,Q8WXF1,P23246,Q15233 10 +Sensory perception of mechanical stimulus 0.3927608985994097 0.6225710760706814 0.5335664232252015 1.0 1.0 13 Q14108 1 +Camera type eye development 0.3444950295516255 0.6205120717568955 0.5349207088457955 1.0 1.0 30 P54802,O94788,P08670,Q12959,Q15293,Q8NF37,O75569 7 +Threonine metabolic process 0.7166612324747452 0.619486778524477 0.5355957292425779 1.0 1.0 2 O75600 1 +Endocrine system development 0.4025937234122134 0.6186285362320203 0.5361610983970899 1.0 1.0 12 O94788 1 +Binding of sperm to zona pellucida 0.4121761543548013 0.6175831182595782 0.5368501755690145 1.0 1.0 11 P45880 1 +Sperm egg recognition 0.4121761543548013 0.6175831182595782 0.5368501755690145 1.0 1.0 11 P45880 1 +Regulation of activin receptor signaling pathway 0.705498858101185 0.6174788240057449 0.5369189445416944 1.0 1.0 3 P62942 1 +Activin receptor signaling pathway 0.705498858101185 0.6174788240057449 0.5369189445416944 1.0 1.0 3 P62942 1 +Response to muscle activity 0.7048881976959835 0.6154952857554665 0.538227681667748 1.0 1.0 3 P25705 1 +Negative regulation of cytokine production 0.3417556409771399 0.6149756686235925 0.5385707890787297 1.0 1.0 25 P30536,P09601,P04062,O43823 4 +Phosphatidylinositol dephosphorylation 0.7041748206131678 0.6131804784764916 0.5397570112026857 1.0 1.0 3 Q13614,Q10713 2 +Regulation of receptor binding 0.7040953878300269 0.612922889220801 0.539927327749584 1.0 1.0 3 P16615 1 +Transferrin transport 0.5471826009852846 0.6091664330708515 0.54241412711844 1.0 1.0 4 P50570 1 +Regulation of synapse structure or activity 0.3431447770519317 0.6091574554305031 0.5424200772098979 1.0 1.0 33 Q8N5V2,P50897,Q9UQB8,O00264,Q13641,P07437 6 +Regulation of receptor localization to synapse 0.7019378937994798 0.6059387072836083 0.5445554549300611 1.0 1.0 3 Q16643 1 +Negative regulation of protein catabolic process 0.340132792441679 0.6044805144637967 0.5455242202629251 1.0 1.0 39 P46379,Q96HY6,P10619,Q16850 4 +Ganglioside catabolic process 0.7005870841487055 0.6015780573000329 0.5474550386354542 1.0 1.0 3 P06865,P07686 2 +Ganglioside metabolic process 0.7005870841487055 0.6015780573000329 0.5474550386354542 1.0 1.0 3 P06865,P07686 2 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.4971886180892357 0.5998225433969941 0.548624507607999 1.0 1.0 5 O15460,P13674 2 +Positive regulation of erbb signaling pathway 0.4968744190188062 0.5985590206499357 0.5494669899794931 1.0 1.0 5 O00291,Q9NQC3 2 +Cell fate specification 0.4967362924281967 0.5980037525022078 0.5498374292342314 1.0 1.0 5 P35222,P25054,P05556,Q9UJX6 4 +Inorganic anion transmembrane transport 0.408494560736701 0.5977103083601104 0.5500332460160204 1.0 1.0 11 Q9UHG3,Q9UBX3 2 +Negative regulation of myosin light chain phosphatase activity 0.7101402021519345 0.5973093877389558 0.5503008379241905 1.0 1.0 2 Q13464 1 +Negative regulation of biomineralization 0.7101402021519345 0.5973093877389558 0.5503008379241905 1.0 1.0 2 Q13464 1 +Negative regulation of bicellular tight junction assembly 0.7101402021519345 0.5973093877389558 0.5503008379241905 1.0 1.0 2 Q13464 1 +Middle ear morphogenesis 0.699243088834381 0.5972488095838732 0.5503412760010375 1.0 1.0 3 P54802 1 +External encapsulating structure organization 0.3409740686291332 0.5970460560608057 0.5504766318443837 1.0 1.0 28 Q07954,P41440,P39210 3 +Hindbrain development 0.3409936094169953 0.5946175643248641 0.5520991365919832 1.0 1.0 29 Q5KU26,Q7Z4L5,Q14103,P54802,O94788,O14949,P04062 7 +Spermine metabolic process 0.7085099445712466 0.5918073298922079 0.5539796142881053 1.0 1.0 2 Q96QD8 1 +Regulation of actin cytoskeleton reorganization 0.4329838769642401 0.5900508296313008 0.5551565724912488 1.0 1.0 9 Q9UQB8 1 +Glycosyl compound metabolic process 0.3396725864197247 0.586922793587384 0.5572555605729597 1.0 1.0 28 Q9NUJ1,Q13126,O60725,P00813,Q9BTY2,P55263 6 +Nucleoside phosphate catabolic process 0.3593793362327129 0.5797666317849718 0.5620720026100239 1.0 1.0 19 P00813,O60658 2 +Utp biosynthetic process 0.5392410715501147 0.5797335638096501 0.5620943055578775 1.0 1.0 4 P22392 1 +Positive regulation of amyloid precursor protein biosynthetic process 0.6937167435091876 0.5795481180876983 0.5622193887595617 1.0 1.0 3 Q96IZ0 1 +Regulation of dna methylation dependent heterochromatin assembly 0.4469550105308295 0.574806619387801 0.5654220894906694 1.0 1.0 7 Q8NEY8 1 +Kidney morphogenesis 0.4903147958474038 0.5723244988704935 0.5671021553454556 1.0 1.0 5 O75844 1 +Regulation of plasma membrane organization 0.5367931471315348 0.5707396906286168 0.5681761097337565 1.0 1.0 4 P50570 1 +Cell death in response to hydrogen peroxide 0.4165309772144543 0.5699719442766379 0.5686967270006316 1.0 1.0 10 O60658,Q99720 2 +Negative regulation of natural killer cell mediated immunity 0.69067587986258 0.5698791181568363 0.5687596888611903 1.0 1.0 3 P04439 1 +Positive regulation of blood brain barrier permeability 0.6904761904761691 0.5692459642701957 0.5691892316629656 1.0 1.0 3 Q9UDY2,Q16625 2 +Positive regulation of vascular permeability 0.6904761904761691 0.5692459642701957 0.5691892316629656 1.0 1.0 3 Q9UDY2,Q16625 2 +Regulation of blood brain barrier permeability 0.6904761904761691 0.5692459642701957 0.5691892316629656 1.0 1.0 3 Q9UDY2,Q16625 2 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.701336811216171 0.5678068303946842 0.570166141334649 1.0 1.0 2 P51572 1 +Amp biosynthetic process 0.3934282801120863 0.5675275431482165 0.5703558190576206 1.0 1.0 12 P00813,P55263 2 +Golgi to lysosome transport 0.5355527454878154 0.5661970344604442 0.5712598456625253 1.0 1.0 4 O14976 1 +Neuron projection guidance 0.35339971657464 0.5660141155584759 0.5713841849205301 1.0 1.0 20 Q9BVA1,P35613,P33176,O00264,P42892,P98172,O15031 7 +Skeletal muscle organ development 0.3359552335774725 0.5659219856246093 0.5714468151860022 1.0 1.0 26 P51114,P41440,Q92841,P17844,P50402,Q9Y5Q8,P61201,P60660,Q15149 9 +Steroid biosynthetic process 0.332069798746037 0.5645698151686321 0.5723664010833354 1.0 1.0 43 P37268,Q14739,Q9H3P7,Q9H4L5,Q15800,Q13510,P30536,Q9UHI6,Q15392,P48449,P16435,Q16850 12 +Oligosaccharide catabolic process 0.7003586566677499 0.5645609858543593 0.5723724080442814 1.0 1.0 2 P07686 1 +Serine family amino acid metabolic process 0.3825998390495323 0.5636800924451015 0.572971868052826 1.0 1.0 13 P34897,P49903,O75600,P48507,P25325,P00374,P32929 7 +Histone h2b ubiquitination 0.4880811576872624 0.5634563745633637 0.5731241585512272 1.0 1.0 5 Q5VTR2,O75150 2 +Dicarboxylic acid transport 0.3634068386109235 0.5610656803059664 0.5747527631292111 1.0 1.0 17 Q9UBX3,P41440,Q9BQT8 3 +Folic acid containing compound metabolic process 0.3821217974170381 0.5609346680779493 0.5748420753841326 1.0 1.0 13 P00374,P41440,Q9NRN7 3 +Peroxisomal transport 0.4869258552257444 0.5588829762036761 0.5762415884131404 1.0 1.0 5 O75381,P56589 2 +Lymphocyte activation 0.3044954314436614 0.5577964180964219 0.5769834089013004 1.0 1.0 92 P78318,P14174,Q5RKV6,P12956,P00813,P46379,P49366,P02786,Q9Y255,Q9NQT5,Q9UQ84,P30825,Q96IZ0,P62942,P04439,Q12959,Q00577,O96005,P04062 19 +Response to nutrient 0.3364673551573073 0.5571586483497752 0.5774190398143695 1.0 1.0 30 P09601,O94788,P53985 3 +Branching morphogenesis of a nerve 0.6977502445386359 0.5559378260572566 0.5782533585908032 1.0 1.0 2 Q9NQC3 1 +Negative regulation of synapse organization 0.6977502445386348 0.5559378260572527 0.5782533585908058 1.0 1.0 2 O00264 1 +Response to x ray 0.4129904396926998 0.5519688240632971 0.5809697130946163 1.0 1.0 10 P50570,Q70UQ0 2 +Positive regulation of wnt signaling pathway 0.3547708444410273 0.5491924720537237 0.5828733700273405 1.0 1.0 19 Q9H2V7,Q7Z4L5,Q8N163,Q96K76 4 +Mating behavior 0.6836268754076888 0.547666206623691 0.5839211200877952 1.0 1.0 3 Q7Z7E8,P07686 2 +Reproductive behavior 0.6836268754076888 0.547666206623691 0.5839211200877952 1.0 1.0 3 Q7Z7E8,P07686 2 +G protein coupled receptor signaling pathway 0.3290098440144443 0.5469745252002809 0.5843962338718569 1.0 1.0 44 P50570,P07602,O43865,Q15043,P00813,P11717,P42892,O43813,Q99720 9 +Regeneration 0.3353065316687808 0.5459281895578626 0.5851153001592737 1.0 1.0 33 Q96G23,P09601,P07196,P30536,P11717,Q7Z4V5 6 +Mitochondrial protein processing 0.4627923651319365 0.5447937608286344 0.585895370264383 1.0 1.0 6 Q9Y4W6,Q10713 2 +Attachment of mitotic spindle microtubules to kinetochore 0.4402382845340005 0.5444936225058282 0.5861018358439687 1.0 1.0 7 Q96GD4,Q96DB5 2 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.4113426666131309 0.5436268721261405 0.5866982640476146 1.0 1.0 10 O43657,Q9NUD5,Q14671 3 +Nerve growth factor signaling pathway 0.6938376263449663 0.5430930582062894 0.5870657319324564 1.0 1.0 2 Q99523 1 +Regulation by virus of viral protein levels in host cell 0.5289554523799133 0.5422075323862616 0.5876755468933226 1.0 1.0 4 Q9P035 1 +Peptidyl asparagine modification 0.4315031904855702 0.541184351266016 0.5883805224763845 1.0 1.0 8 P46977,Q8TCJ2,P04843 3 +Negative regulation of map kinase activity 0.4228499106137613 0.5406298535820276 0.5887627366141417 1.0 1.0 9 Q96JB5,P04062 2 +Mammary gland development 0.356423327791081 0.5370320897111518 0.5912454482442855 1.0 1.0 18 P00403,Q13505 2 +Cellular response to reactive oxygen species 0.3337492370683015 0.5359376637629125 0.5920016330943279 1.0 1.0 30 O95831,P39210,Q99720 3 +Ribonucleoside triphosphate biosynthetic process 0.332437020979317 0.53484301641605 0.59275841471838 1.0 1.0 27 P25705,O75964,P00846,P00403,P22392 5 +Purine containing compound catabolic process 0.3775234324538684 0.5346520561527593 0.5928904800244628 1.0 1.0 13 P00813 1 +Sulfur amino acid metabolic process 0.3966064887980807 0.5343334137580039 0.5931108784330905 1.0 1.0 11 P25325,P32929,Q13126 3 +Chemical homeostasis 0.3651326070982688 0.5341699951082063 0.5932239263210821 1.0 1.0 178 O43819,P04062,P62995,Q8TAD4,Q93050,Q14344,P42785,Q15043,Q16891,Q8WTV0,Q13586,Q8IYU8,P30536,P49366,P35610,P30519,P07686,Q96A33,P02786,P85037,O15260,P51790,Q96AQ8,Q9BPX6,Q8N511,Q15904,Q9Y487,P09601,P17480,Q8NE01,P50897,Q9P035,Q15067,O00459,Q8N5M9,Q96TC7,P53985,P08133,O75503,Q99808,Q9Y3B8,O75027,O15254,Q8NEW0,P16615,Q9HD20,Q9H4A3,Q9Y6C9,Q14BN4,P35670,P34913,P62942,O60826,Q6P4Q7,P48507,Q8WWC4,O15118,Q9H4I9,Q9Y6M7,Q8NF37,Q16531 61 +Pyrimidine ribonucleoside triphosphate biosynthetic process 0.4377131914080965 0.5331863093692019 0.5939046176272984 1.0 1.0 7 Q9BZX2,P15531,P22392,Q9NRF8 4 +Isocitrate metabolic process 0.4803389748924103 0.5329896895626044 0.5940407175289335 1.0 1.0 5 P50213,P48735,O75874 3 +Positive regulation of protein export from nucleus 0.3766983034316954 0.5299608955836435 0.5961390435485305 1.0 1.0 13 P12270,P50402,Q9Y3B8 3 +Positive regulation of connective tissue replacement 0.6769579131791919 0.5269195800546852 0.5982494361320196 1.0 1.0 3 Q13464 1 +Positive regulation of tissue remodeling 0.6769579131791919 0.5269195800546852 0.5982494361320196 1.0 1.0 3 Q13464 1 +Connective tissue replacement 0.6769579131791919 0.5269195800546852 0.5982494361320196 1.0 1.0 3 Q13464 1 +Regulation of connective tissue replacement 0.6769579131791919 0.5269195800546852 0.5982494361320196 1.0 1.0 3 Q13464 1 +Cellular response to corticosteroid stimulus 0.3857064386120278 0.5250980033661292 0.5995150640303191 1.0 1.0 12 O95831 1 +Pyrimidine nucleoside triphosphate biosynthetic process 0.419406158026657 0.5240238873794985 0.6002619255485437 1.0 1.0 9 Q9NRF8,Q9BZX2,Q05682,P22392,P15531 5 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.3755775184304459 0.5236014411123275 0.6005557789618383 1.0 1.0 13 O95831,Q9NR28 2 +Regulation of bmp signaling pathway 0.4183006535947732 0.5187148035603387 0.6039596369072582 1.0 1.0 9 Q9BRX2,Q9C0C9,Q05D32,Q8NC56,Q14318,Q9Y2U8,Q9UPN9,P98170 8 +Negative regulation of atp dependent activity 0.4343489571222716 0.5182007528552433 0.6043182095660822 1.0 1.0 7 Q15070,Q9UII2,P33993 3 +Intracellular mrna localization 0.686012389957632 0.5177380847652787 0.6046410223084466 1.0 1.0 2 Q99729 1 +Dna unwinding involved in dna replication 0.363990429238293 0.5176226443978414 0.604721579409627 1.0 1.0 14 Q9BRT9,Q14566,P33991 3 +Regulation of mrna processing 0.2949922208419437 0.5152300371295032 0.6063922816952081 1.0 1.0 85 P51114,O43865,P62995,P98175,Q9UHX1,Q13242,O75150,Q9BWF3,Q96E39,P98179,O75525,Q07021,Q92841,Q96PU8,P38159,Q07666,P22626,Q8IY67,Q16629,P61978,Q8N684,Q5VTR2,Q14011,P17844,O75494 25 +Regulation of neurogenesis 0.3117762415629739 0.5149224377017841 0.6066072209078905 1.0 1.0 53 Q96G23,P07196,Q9UQB8,P30536,P55209 5 +Positive regulation of cell growth 0.3308754685115422 0.514489327986667 0.6069099198279235 1.0 1.0 36 Q9Y3B8,P51812,Q15418,Q96K76,O95684,Q7Z4V5 6 +Fatty acid elongation 0.6847081838930532 0.5135568889571248 0.6075618272154655 1.0 1.0 2 Q9P035 1 +Postsynapse organization 0.3311483558918713 0.5133176950352646 0.6077291080979608 1.0 1.0 34 P07196,Q16352,Q9UQB8 3 +Snrna metabolic process 0.352703594077895 0.5131936811706587 0.6078158455980185 1.0 1.0 18 Q9NQT5,Q5RKV6 2 +Positive regulation of cell death 0.3154474654936454 0.512566234531913 0.6082547775258735 1.0 1.0 110 P50570,O95831,Q7Z3C6,O94788,Q9NQX7,Q07954,P09601,Q9NR28,Q8N163,P30536,P11717,P98175,Q9NS69,P00403,Q96IZ0,Q9Y255,Q969S3 17 +Regulation of response to oxidative stress 0.3370634781461448 0.5125566864533186 0.608261457999999 1.0 1.0 22 O60658,Q9UL15,Q96IZ0,P23246,O43813,Q15233 6 +Positive regulation of pathway restricted smad protein phosphorylation 0.6843821323769117 0.5125136236317406 0.6082915880351918 1.0 1.0 2 P67870 1 +Protein localization to endoplasmic reticulum 0.330892995102417 0.5110465197757563 0.609318482794428 1.0 1.0 32 P46379,Q15629 2 +Male mating behavior 0.6834039778284922 0.509388735628204 0.6104797704166216 1.0 1.0 2 P07686 1 +Walking behavior 0.5191070829410366 0.5069633549229132 0.6121805309489727 1.0 1.0 4 O15118 1 +Inorganic ion import across plasma membrane 0.423978610402163 0.5064028412370123 0.6125738804043532 1.0 1.0 8 Q15043,Q9H4A3 2 +Regulation of biomineralization 0.4533104080347976 0.5054146377935805 0.6132676399203205 1.0 1.0 6 O75844,Q13464 2 +Purine nucleoside monophosphate biosynthetic process 0.3618219535767952 0.5048728772381035 0.6136481252627268 1.0 1.0 14 P00813,P55263 2 +Protein localization to vacuole 0.3478779093432146 0.5040084933800069 0.6142554085434351 1.0 1.0 19 P20645,Q7Z3T8,Q99523,O14964,Q9BRG1,Q14108,Q9NQC3,Q9Y2T2,Q92783 9 +Exocyst localization 0.6814476687316611 0.5031611990286657 0.6148509422163952 1.0 1.0 2 O60645 1 +Positive regulation of cellular amide metabolic process 0.2833916402456067 0.5031132778088245 0.6148846319623329 1.0 1.0 64 Q6P087,Q567V2,Q9Y2R0,Q14103,Q13217,Q14011,Q71RC2,P08670,O60506,A9UHW6,P98179,O15031,P67809 13 +Positive regulation of translation 0.294490257957158 0.5014263826628719 0.6160710761009827 1.0 1.0 60 Q6P087,Q567V2,Q9Y2R0,Q14103,Q13217,Q14011,Q71RC2,P08670,O60506,A9UHW6,P98179,O15031,P67809 13 +Somatic diversification of immune receptors 0.3307588550910756 0.5008396725412104 0.616483962440693 1.0 1.0 23 Q9UQ84,P02786,P20585,Q5RKV6 4 +Axon development 0.2823794248992441 0.5006468553754605 0.616619680433445 1.0 1.0 72 P41440,Q96G23,Q9BVA1,P07196,Q9UQB8,P30536,P42892,O15031 8 +Myelin maintenance 0.66815923123212 0.4999685739726202 0.6170972056550168 1.0 1.0 3 O15121 1 +Spermidine metabolic process 0.6676063118319839 0.498291519808755 0.618278584108849 1.0 1.0 3 P49366 1 +Embryo implantation 0.3895318710723504 0.4972667959170045 0.6190009234649918 1.0 1.0 11 Q96GC9,Q8IZL8,Q7Z7E8,Q07021 4 +Hepatic stellate cell activation 0.6669071373062306 0.4961737299095647 0.619771843750736 1.0 1.0 3 Q15418 1 +Fibroblast activation 0.6669071373062306 0.4961737299095647 0.619771843750736 1.0 1.0 3 Q15418 1 +Response to ketone 0.328451403061764 0.4947949303050341 0.6207448833453777 1.0 1.0 36 O95831,Q13126,P16278,P07196,O43823 5 +Alcohol metabolic process 0.2845013898752214 0.4940979200558338 0.6212370267337248 1.0 1.0 75 P37268,O94788,P30837,Q8WTV0,Q15800,Q13510,P48735,P00374,Q6NUM9,P61457,O15118,Q15392,P48449,P04062,Q16850 15 +Maintenance of dna repeat elements 0.5151208550868532 0.4929031357192274 0.622081031543587 1.0 1.0 4 O75844 1 +Histone h3 k4 demethylation trimethyl h3 k4 specific 0.6775350505379845 0.4907963747098162 0.6235704743844834 1.0 1.0 2 P29375 1 +Regulation of histone h3 k9 methylation 0.4117228472954731 0.4873552746375192 0.6260065829100245 1.0 1.0 9 P46100 1 +Protein refolding 0.3871519312504499 0.4849185619861167 0.6277341148465978 1.0 1.0 11 Q9UL15,P48723 2 +Maternal placenta development 0.6628961257567744 0.4840870597753387 0.6283240844971569 1.0 1.0 3 P35613 1 +Serine transport 0.5125661543639827 0.4839573874541749 0.6284161113628008 1.0 1.0 4 Q96QD8 1 +Positive regulation of mammary gland epithelial cell proliferation 0.6749266384088659 0.482621195203481 0.6293647268737734 1.0 1.0 2 Q9NQC3 1 +Isotype switching to iga isotypes 0.662100456620992 0.481702241039448 0.6300174838561172 1.0 1.0 3 Q96FV9,O96028 2 +Negative regulation of cell development 0.3443081531627415 0.4808906900087962 0.6305941899409775 1.0 1.0 19 P30536,Q96G23 2 +Ameboidal type cell migration 0.2787367673453054 0.4784456494472925 0.6323330493590107 1.0 1.0 70 P25705,Q14185,P08133,P42785,Q8WTV0,P98172,P35080,P67870,Q9H6U6,P09601,Q13464,Q07021,Q13641,Q15149,P35579,P57105,Q9NQC3,Q13685,Q4VCS5 19 +Regulation of vacuole organization 0.3770181872057448 0.4781395655598827 0.632550873041887 1.0 1.0 12 Q14108,Q8TBX8 2 +Protein targeting to peroxisome 0.5108523686629537 0.4779854666141351 0.6326605491623156 1.0 1.0 4 O75381,P56589 2 +Positive regulation of bone resorption 0.6726442777959065 0.475513370958059 0.634421105184952 1.0 1.0 2 P02786 1 +Regulation of mitotic cell cycle spindle assembly checkpoint 0.4647848320326891 0.4731767822790993 0.6360870607660725 1.0 1.0 5 P12270 1 +Regulation of immunoglobulin production 0.3519043122233699 0.4725709231624178 0.636519331146683 1.0 1.0 16 P02786,Q5RKV6 2 +Negative regulation of cell junction assembly 0.4239183621302744 0.472356680146744 0.6366722195984276 1.0 1.0 7 Q9H6U6,O75116,Q13464 3 +Muscle adaptation 0.349186383052304 0.4721650548759605 0.6368089806471326 1.0 1.0 17 P16615,P09601,Q13464,P02545 4 +Establishment of protein localization to endoplasmic reticulum 0.3354267836950574 0.4718709212035803 0.6370189249951186 1.0 1.0 21 P46379 1 +Neurotransmitter receptor localization to postsynaptic specialization membrane 0.6585990296693744 0.4712589541698816 0.6374558232337999 1.0 1.0 3 Q12959 1 +Cellular response to xenobiotic stimulus 0.3216263454172474 0.4701900773834776 0.6382192227214671 1.0 1.0 24 P27544,O43169,P02786,P07099 4 +Histone h3 k9 modification 0.3657640408279044 0.4685801068671814 0.6393697993660399 1.0 1.0 13 Q03164,P02545,P46100 3 +Regulation of cd8 positive alpha beta t cell activation 0.6703619171829212 0.4684485892076583 0.6394638277727054 1.0 1.0 2 P04439 1 +Positive regulation of cd8 positive alpha beta t cell activation 0.6703619171829212 0.4684485892076583 0.6394638277727054 1.0 1.0 2 P04439 1 +Cd8 positive alpha beta t cell activation 0.6703619171829212 0.4684485892076583 0.6394638277727054 1.0 1.0 2 P04439 1 +Skeletal system development 0.3210339635099221 0.4680685898930124 0.6397355404130369 1.0 1.0 43 Q32P28,Q7Z3C6,Q15043,P08133,Q15904,O75844,P51812,Q12959,P07686,Q96HY6,Q92896,P16435,O75569,O96028 14 +Striated muscle cell proliferation 0.5073409461663732 0.4658243025828494 0.6413412680427841 1.0 1.0 4 P10644,Q8NDZ4,P06493 3 +Retinoic acid receptor signaling pathway 0.4223034383782228 0.465347722413672 0.6416824648394988 1.0 1.0 7 O94788 1 +Protein localization to ciliary membrane 0.4624921734731038 0.4645319798230129 0.6422666528960401 1.0 1.0 5 Q96A65,Q9UPT5 2 +Regulation of transcription regulatory region dna binding 0.4068042560610446 0.4641781068499353 0.6425201452994482 1.0 1.0 9 Q96HY6 1 +Regulation of telomerase activity 0.3379964104886516 0.4631636120494253 0.6432470964737935 1.0 1.0 20 P27544,Q96GD4,P22626,P78371 4 +Negative regulation of transport 0.2764845442572019 0.4622762142642553 0.6438832545663358 1.0 1.0 69 P00813,P21796,Q16850 3 +Neuropeptide signaling pathway 0.6552511415524955 0.4613531462420595 0.6445452609167204 1.0 1.0 3 Q99523,Q9Y4G8 2 +Learning 0.3498325350589694 0.4601293271070372 0.6454233947759382 1.0 1.0 16 Q13641,O00264,P50897 3 +Regulation of dna binding transcription factor activity 0.2853534155113155 0.4598934756838871 0.6455926834595471 1.0 1.0 62 P41440,P09525,P09601,O75381,P02786,Q00577,Q96HY6,Q96JB5,P32929 9 +Mitotic g2 m transition checkpoint 0.3734975251114744 0.4593715575198858 0.6459673694869048 1.0 1.0 12 Q9NWV8,Q96JB5,Q6NUQ1,P06493 4 +Cotranslational protein targeting to membrane 0.3538410980658754 0.4585086530607132 0.6465870472400335 1.0 1.0 14 Q15629 1 +Lysine metabolic process 0.5049255261735683 0.4575185925019174 0.6472983416960214 1.0 1.0 4 Q9BQT8 1 +Regulation of golgi organization 0.4053484005859163 0.4573651339609558 0.6474086205899623 1.0 1.0 9 Q5VU43,Q9P2W9 2 +Heterotypic cell cell adhesion 0.3936253526935594 0.4555835535766004 0.6486894719170953 1.0 1.0 10 Q08722,P41440,Q9H4A3 3 +Response to toxic substance 0.3132958161204565 0.4504994704854679 0.6523503359072715 1.0 1.0 48 P35670,O95831,P07099,P07196,Q15165,P08183,P27544 7 +Positive regulation of mrna processing 0.3321751096713914 0.4500643711468036 0.652664026180064 1.0 1.0 21 P62995,Q9Y2W1,Q14011,P38159,Q96E39,Q96EP5,P98179 7 +Regulation of nitric oxide metabolic process 0.380332078392557 0.449899463870747 0.6527829341861511 1.0 1.0 11 P50570,Q92945,P30536 3 +Anatomical structure maturation 0.3213230407897895 0.4472443222033782 0.6546986628490647 1.0 1.0 28 O75503,O94788 2 +Perk mediated unfolded protein response 0.6503587736464388 0.4470207351738628 0.6548600886545992 1.0 1.0 3 P05198,P18031 2 +Integrated stress response signaling 0.6503587736464388 0.4470207351738628 0.6548600886545992 1.0 1.0 3 P05198,P18031 2 +Peptidyl lysine acetylation 0.318539250993209 0.4466274159403036 0.6551440972054148 1.0 1.0 43 O95619,Q86UY6,Q01105,P46379,O75844,Q9Y6J9 6 +Regulation of t cell differentiation 0.3617289108648495 0.4463284710970346 0.6553599931282963 1.0 1.0 13 P00813,Q9Y255 2 +Immunoglobulin production 0.3183316783307981 0.4463217776678798 0.6553648274068817 1.0 1.0 24 Q9UQ84,P02786,P20585,Q5RKV6 4 +Zymogen activation 0.4386382519157146 0.4459724638115685 0.6556171367373071 1.0 1.0 6 Q15392 1 +Negative regulation of oxidative stress induced cell death 0.3709485634685364 0.4458842310801885 0.6556808734414499 1.0 1.0 12 Q9UL15,O60658 2 +Skin development 0.3219514698290467 0.4447600694015758 0.6564931538072822 1.0 1.0 37 Q9Y3B8,Q13510,O75844,Q8NEY8,Q15392,Q08J23,P22392 7 +Positive regulation of receptor catabolic process 0.6625366807955634 0.4445613112552474 0.6566368118571306 1.0 1.0 2 Q96J02 1 +Regulation of postsynaptic membrane neurotransmitter receptor levels 0.3706664144593774 0.444396654299752 0.6567558319248796 1.0 1.0 12 O60716,Q12959,Q92796 3 +Pteridine containing compound metabolic process 0.3445979735144238 0.4441289040053354 0.6569493902222336 1.0 1.0 17 P00374,P61457,P41440,Q9NRN7 4 +Muscle structure development 0.2941083370632246 0.4441062112660404 0.6569657959981576 1.0 1.0 91 P51114,P02545,Q9NYL9,O43707,P85037,P32929,P12814,Q14012,Q9BWF3,Q8IV08,P28289,O75844,P60660,P41440,Q92841,Q96PU8,P16615,P46939,P35579,Q99523,P62942,P17844,P50402,Q7Z4V5,P67809 25 +Negative regulation of cell matrix adhesion 0.4380264922068462 0.4435369984461302 0.6573773639821623 1.0 1.0 6 Q9H6U6 1 +Skeletal muscle cell differentiation 0.3911218317558843 0.4434125755394977 0.6574673415149757 1.0 1.0 10 Q92841,P17844,P50402,P61201,Q9Y5Q8 5 +Positive regulation of isotype switching to iga isotypes 0.6618845777632876 0.442594595190369 0.6580589948317974 1.0 1.0 2 O96028 1 +Mitotic spindle midzone assembly 0.4564459620913256 0.4419618711748292 0.6585167973686155 1.0 1.0 5 Q96GD4 1 +Response to interleukin 12 0.6612324747310017 0.4406316181608161 0.6594797089759941 1.0 1.0 2 Q08722 1 +Positive regulation by symbiont of entry into host 0.6612324747310017 0.4406316181608161 0.6594797089759941 1.0 1.0 2 P19474 1 +Negative regulation of response to cytokine stimulus 0.4365600363694317 0.4377137543920049 0.661593797579634 1.0 1.0 6 Q9UIV1,Q9Y3Z3 2 +Regulation of skeletal muscle cell differentiation 0.4990815870227297 0.4376311010884375 0.6616537220453353 1.0 1.0 4 P17844,Q92841 2 +Leukocyte cell cell adhesion 0.318993702978277 0.4370705906525539 0.6620601548514844 1.0 1.0 41 P30825,P04439,P00813,P49366,Q12959,P02786,Q96IZ0,Q9H4A3,P98172 9 +Response to wounding 0.279432598964517 0.4338205729639436 0.6644187408877669 1.0 1.0 75 Q9UNN8,Q96G23,P42785,P09601,P07196,Q8WTV0,P30536 7 +Positive regulation of protein binding 0.3255746003028791 0.4332029682002218 0.6648673227183577 1.0 1.0 22 Q07954,P41440,P62942 3 +Regulation of mitochondrial fusion 0.4976991992258971 0.4329707696493921 0.6650360054049176 1.0 1.0 4 Q99536,P02786 2 +Dna catabolic process exonucleolytic 0.65862406260189 0.4328173719946233 0.6651474517883043 1.0 1.0 2 Q9H0D6 1 +Rna destabilization 0.319619674719134 0.4324570321186171 0.6654092748280493 1.0 1.0 39 Q969T7,Q86VM9,Q9UIV1,Q92945,Q14103,Q13868,Q14671,Q15024,O60506,Q9NQT5,Q5PRF9,Q13464,P67809 13 +Telencephalon glial cell migration 0.4145513544775507 0.4320611693409963 0.6656969558509616 1.0 1.0 7 Q96N66 1 +Cerebral cortex radially oriented cell migration 0.4145513544775507 0.4320611693409963 0.6656969558509616 1.0 1.0 7 Q96N66 1 +Positive regulation of aspartic type peptidase activity 0.6450930359882425 0.4317897809246425 0.6658942074176268 1.0 1.0 3 Q13492 1 +Response to dexamethasone 0.3997678792138504 0.4314602511270211 0.66613374859895 1.0 1.0 9 P16435,P04062,P25705 3 +Diencephalon development 0.4346001674675991 0.4299643208016419 0.6672215954093914 1.0 1.0 6 O75569,O94788 2 +Histone monoubiquitination 0.3883073417571913 0.4298180874737637 0.667327974485572 1.0 1.0 10 Q5VTR2,O75150 2 +Anterior posterior axis specification 0.4342484497927289 0.4285776716066669 0.6682305976617722 1.0 1.0 6 Q9UK61 1 +Regulation of myosin light chain phosphatase activity 0.6438356164383416 0.4281833580695993 0.6685176314912367 1.0 1.0 3 O75116,Q13464 2 +Regulation of response to endoplasmic reticulum stress 0.3360035576398663 0.427942917859585 0.6686926796400181 1.0 1.0 19 P46379 1 +Sensory system development 0.3194273699672759 0.4214161482012321 0.6734512294882009 1.0 1.0 35 P54802,O94788,P28289,P08670,Q12959,Q15293,Q8NF37,O75569,P48681 9 +Response to inorganic substance 0.3020372238751491 0.420809198062442 0.67389441450899 1.0 1.0 103 O43865,P09960,Q8TAD4,P25705,P30536,P02786,P46100,O60658,P35611,P09601,Q96QD8,Q14168,P50995,P50570,O95831,P00374,Q96IZ0,O60888,P35670,Q9UBV8,P03915,P07196,O15118,Q99720 24 +Regulation of chromatin assembly 0.356023134866744 0.4152716874845942 0.677943024996166 1.0 1.0 13 P12270,Q8NEY8 2 +Spindle elongation 0.4104044634050542 0.414511168311533 0.6784997895805915 1.0 1.0 7 Q96GD4 1 +Positive regulation of glycoprotein metabolic process 0.4025849315155992 0.4104325321300394 0.681488685979236 1.0 1.0 8 Q08379,Q96IZ0 2 +Pyramidal neuron differentiation 0.6374078377294818 0.4099367593228402 0.6818523391874534 1.0 1.0 3 P04062 1 +Negative regulation of ubiquitin dependent protein catabolic process 0.3176675803042369 0.408713592373443 0.6827498576400368 1.0 1.0 23 P46379,Q9UL15,Q8N163,Q96HY6 4 +Prostanoid metabolic process 0.3637583246409564 0.4083237304096081 0.6830360195104888 1.0 1.0 12 Q8N4Q0,P14174,Q9H7Z7,Q15067 4 +Detection of stimulus 0.3431397267969785 0.4080105714540015 0.6832659137418298 1.0 1.0 15 Q8WTV0 1 +Positive regulation of ire1 mediated unfolded protein response 0.6501467231822602 0.4078461959927234 0.6833865957521563 1.0 1.0 2 P18031 1 +Positive regulation of endoplasmic reticulum unfolded protein response 0.6501467231822602 0.4078461959927234 0.6833865957521563 1.0 1.0 2 P18031 1 +Regulation of perk mediated unfolded protein response 0.6501467231822602 0.4078461959927234 0.6833865957521563 1.0 1.0 2 P18031 1 +Maintenance of protein localization in organelle 0.3542000262080436 0.4054547550864627 0.6851432696982589 1.0 1.0 13 P30536,P36404 2 +Vocalization behavior 0.6488425171177009 0.4040634615924675 0.6861660528561926 1.0 1.0 2 Q15334 1 +Regulation of stem cell population maintenance 0.4460053836613433 0.4038122673882856 0.6863507748775444 1.0 1.0 5 Q15061,Q9NZN8,Q9Y6J9 3 +Positive regulation of torc1 signaling 0.6342041615152976 0.4009629265824914 0.6884474192442127 1.0 1.0 3 Q9P2J5 1 +Regulation of proton transport 0.4069801701273545 0.4001616415941226 0.68903746508356 1.0 1.0 7 Q8TAD4 1 +Negative regulation of cellular protein catabolic process 0.3154220894291393 0.3998840972882669 0.6892418857738678 1.0 1.0 29 Q9UL15,Q8N163,P46379,Q96HY6,Q96JB5 5 +Response to cadmium ion 0.3619902673069199 0.3992033601125488 0.6897433675803151 1.0 1.0 12 P09601 1 +Negative regulation of dendritic spine morphogenesis 0.6334713791714279 0.3989218034062163 0.6899508231185709 1.0 1.0 3 Q8N5V2 1 +Positive regulation of peptidase activity 0.315169445070124 0.3963707488903608 0.6918315417375083 1.0 1.0 39 O95831,Q9NR28,Q06323,Q96HY6,Q9UL46,Q9Y255,O00291 7 +O glycan processing 0.4436865479015934 0.3954890219868628 0.6924820218714336 1.0 1.0 5 Q86SF2,O43505 2 +Muscle cell proliferation 0.3236912097409407 0.394147576994811 0.6934720867783057 1.0 1.0 21 P06493,P12956,P09601,Q5VZE5 4 +Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.4037644573827288 0.3868080021835244 0.6988983526156651 1.0 1.0 7 Q9UL15 1 +Positive regulation of protein tyrosine kinase activity 0.4832054397204176 0.3851820516094858 0.7001025401408962 1.0 1.0 4 Q92796,Q15334 2 +Adult locomotory behavior 0.3389225951039143 0.3840520196784527 0.7009398922306258 1.0 1.0 15 P28289,P50897,O75844,O15118,P51790 5 +Regulation of nucleocytoplasmic transport 0.3030798610335734 0.3835509556659296 0.7013112963386954 1.0 1.0 50 P12270,Q9BVS4,Q9BWF3,Q9Y3B8,Q9NPF5,O00459,P06493,Q9H7Z3,P50402,Q9ULX6,Q7Z3B4,Q14978,Q08J23,Q14012,Q07666 15 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.4809135399673582 0.3778127294229715 0.7055697167125607 1.0 1.0 4 P25054,O00410,O95373 3 +Amino acid transport 0.320985510189247 0.376637227227001 0.7064432183393312 1.0 1.0 21 P08195,Q6P4A7,P30825,Q9H2J7,Q15758,Q96QD8,Q8TDW0,Q96EV8 8 +Positive regulation of transporter activity 0.3276666968498489 0.3761015326402018 0.7068414149499911 1.0 1.0 19 P50570,Q96GC9,O43707,P08183,Q03164 5 +Protein maturation by protein folding 0.4205540437035683 0.375600073867718 0.7072142358415461 1.0 1.0 6 Q8N4Q1,P62942 2 +Mitotic chromosome condensation 0.3651453131871514 0.3740961311461288 0.7083327969750379 1.0 1.0 11 O43823 1 +Embryonic axis specification 0.4374030639820603 0.3732235962696895 0.7089820356450236 1.0 1.0 5 Q9UK61 1 +Mesenchymal cell differentiation 0.3125579568735335 0.3706513840991607 0.7108972048126441 1.0 1.0 32 Q9UBV8,O94788,Q92841,P08133,P17844,Q9UK61,Q99729,Q14978,P98172,Q13464 10 +Mucopolysaccharide metabolic process 0.3933193031189759 0.3704299217721577 0.7110621826179611 1.0 1.0 8 O43505,P16278 2 +Membrane protein intracellular domain proteolysis 0.6364525595043982 0.3689418760747537 0.7121710491844144 1.0 1.0 2 Q8TCT9 1 +Endosome to lysosome transport 0.3373695247880284 0.3660173185102741 0.7143521526402206 1.0 1.0 14 P20645,Q9P253 2 +Regulation of endocytosis 0.3089142912734327 0.3654421347854222 0.7147813938537357 1.0 1.0 43 P41440,P61978,Q07954,P57105,P50897,O00291 6 +Protein o linked glycosylation 0.3353441557261177 0.3639844100582464 0.7158696510337068 1.0 1.0 15 Q86SF2,O43505,Q8NAT1,Q10472,O60502 5 +Regulation of oxidoreductase activity 0.3332347925890517 0.3631186144613691 0.7165162799718436 1.0 1.0 16 Q15070,P16435,P00374,Q8WTV0 4 +Trna methylation 0.3546799586865323 0.3620141339994031 0.7173414683921995 1.0 1.0 12 Q96FX7 1 +Protein containing complex localization 0.3044202780491231 0.3603088950538952 0.7186161481377775 1.0 1.0 47 Q7Z4L5,Q9BVS4,A0AVF1,Q96GA3,P57105,O00291,Q92796,Q99567,Q16643,Q12959,O60645,Q00577,Q14168,P23246,O43805,Q9BTX1,O15400 17 +Nuclear transcribed mrna catabolic process deadenylation dependent decay 0.3084462146119149 0.3582976298730616 0.7201205916200766 1.0 1.0 27 Q969T7,Q9UIV1,Q14103,Q13868,Q15024,O60506,Q9NQT5,Q5PRF9,P67809 9 +Histone h4 acetylation 0.3054515447706335 0.3553947407135405 0.7222938883475214 1.0 1.0 24 O75844,Q86UY6,O95619 3 +Positive regulation of telomere capping 0.4322519655129971 0.3552971266009601 0.7223670078673188 1.0 1.0 5 Q96GD4 1 +Positive regulation of reactive oxygen species metabolic process 0.3337070204782528 0.3548873579766696 0.7226739797206363 1.0 1.0 15 P00403 1 +Protein localization to chromosome telomeric region 0.3241830042118505 0.3548715157342847 0.7226858485891521 1.0 1.0 19 O14773,P46100 2 +Embryonic placenta morphogenesis 0.6309096837300245 0.3537215331969196 0.723547583436696 1.0 1.0 2 P62993 1 +Protein o linked mannosylation 0.4731522665819733 0.3532599397519722 0.7238935753156575 1.0 1.0 4 Q8NAT1 1 +Calcium ion transport 0.289353745277896 0.3527571522315038 0.7242705088150485 1.0 1.0 56 Q96GC9,P62942,P08133,Q8IYU8,P30536,O75844,Q8WWC4,Q9H4I9,P21796,Q9BPX6 10 +Negative regulation of blood circulation 0.6161163018042577 0.3518766740881873 0.7249307532483908 1.0 1.0 3 P16615 1 +Mitochondrial depolarization 0.4312525746307319 0.3518543082981221 0.7249475273570709 1.0 1.0 5 P30536,P48507 2 +Spinal cord development 0.352645495792982 0.3518205912836112 0.7249728150148871 1.0 1.0 12 O75312,Q9UKA9,P07196,P25325,Q14203 5 +Receptor internalization 0.304593368551066 0.3494856693470346 0.7267247276017295 1.0 1.0 24 P50570,P41440,Q07954,Q8NBU5,P02786,Q15334,Q13614,Q96EV8,Q13492 9 +Water homeostasis 0.3813405557855198 0.3485499136690549 0.7274272352725912 1.0 1.0 9 Q9Y3B8,P04062,P16949 3 +Negative regulation of immune response 0.3197445506140119 0.3468680416817873 0.7286904568032722 1.0 1.0 20 P28070,Q9UIV1,Q9Y3Z3,P09601,P46108,P04439,P19474 7 +Regulation of maintenance of sister chromatid cohesion 0.4295837024925223 0.3461311891262415 0.7292441249242141 1.0 1.0 5 P46100 1 +Regulation of potassium ion import 0.4707585213622176 0.3458162814429431 0.7294807884140251 1.0 1.0 4 Q9H4A3 1 +Axon ensheathment in central nervous system 0.6279752200847691 0.3457907570152491 0.7294999719911088 1.0 1.0 2 Q92542 1 +Paraxial mesoderm development 0.6135255329759289 0.3450746719779991 0.7300382341229643 1.0 1.0 3 Q96A65 1 +Trna catabolic process 0.3801385283962251 0.3432960395109165 0.7313757599957105 1.0 1.0 9 Q9NQT5,Q08J23 2 +Morphogenesis of an endothelium 0.6269970655363591 0.343166978230699 0.7314728454967643 1.0 1.0 2 P67870 1 +Positive regulation of neuroblast proliferation 0.6269970655363519 0.3431669782306798 0.7314728454967787 1.0 1.0 2 O60341 1 +Ganglion development 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q13509 1 +Fungiform papilla development 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q92769 1 +Dorsal root ganglion development 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q13509 1 +Fungiform papilla morphogenesis 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q92769 1 +Tongue development 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q92769 1 +Ectodermal placode development 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q92769 1 +Hair follicle placode formation 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q92769 1 +Tongue morphogenesis 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 Q92769 1 +Cardiac conduction system development 0.6263449625040767 0.3414233313040799 0.7327849133461921 1.0 1.0 2 Q14126 1 +Positive regulation of pseudopodium assembly 0.6263449625040707 0.3414233313040646 0.7327849133462037 1.0 1.0 2 P25054 1 +Pseudopodium organization 0.6263449625040707 0.3414233313040646 0.7327849133462037 1.0 1.0 2 P25054 1 +Negative regulation of protein containing complex assembly 0.3087147895660668 0.3395255677787316 0.73421383945634 1.0 1.0 36 P35080,Q12792,P16949,P35611,P28289,Q9NYL9,Q13813,Q9UEY8,P45880,Q01082,P04062 11 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.3919332745920686 0.3387598006286677 0.7347906869298138 1.0 1.0 7 P04062,Q96CV9 2 +Response to mitochondrial depolarisation 0.3919332745920686 0.3387598006286677 0.7347906869298138 1.0 1.0 7 P04062,Q96CV9 2 +Mitochondrial translational elongation 0.4678629690048781 0.3368957490445552 0.7361954899673264 1.0 1.0 4 P43897,Q9H9J2,Q96RP9 3 +Regulation of guanyl nucleotide exchange factor activity 0.4677853560984493 0.3366579147226609 0.7363747923434574 1.0 1.0 4 P05198,P16949 2 +Positive regulation of release of cytochrome c from mitochondria 0.4099993499889386 0.3362233481159841 0.7367024475051691 1.0 1.0 6 Q96A26 1 +C4 dicarboxylate transport 0.3846111165964305 0.3338278825908315 0.7385094419536216 1.0 1.0 8 Q9UBX3 1 +Cellular response to topologically incorrect protein 0.3077387544804597 0.3322843401085903 0.7396745635548889 1.0 1.0 34 P46379,P48723,Q96HY6,Q96CV9,Q7Z2K6,Q96JB5 6 +Crd mediated mrna stabilization 0.3775583120517702 0.3320874972322 0.7398231906917383 1.0 1.0 9 O60506,P67809 2 +Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.3775583120517702 0.3320874972322 0.7398231906917383 1.0 1.0 9 O60506,P67809 2 +Histone lysine demethylation 0.3841335103083878 0.3318500933966906 0.740002456495763 1.0 1.0 8 O75151,Q8IUF8,Q8NB78,P29375,Q9H6W3 5 +Negative regulation of bmp signaling pathway 0.4659053833605101 0.3309175017630303 0.740706801583707 1.0 1.0 4 Q05D32,Q9Y2U8,Q9UPN9 3 +Skin epidermis development 0.3665746886225844 0.3283707674394174 0.7426313428955029 1.0 1.0 10 Q08J23 1 +Maintenance of protein location in cell 0.322454261387236 0.328089371982128 0.742844089574273 1.0 1.0 18 P30536,Q9UH99,Q12792,P36404 4 +Axis specification 0.3888490313009227 0.3265310073301637 0.7440226333031801 1.0 1.0 7 Q9UK61 1 +Positive regulation of cell junction assembly 0.3549006183086886 0.3249104473112117 0.7452488497065444 1.0 1.0 11 Q13641,P41440 2 +Polyadenylation dependent rna catabolic process 0.4067566424636087 0.3244012119605138 0.7456343023041752 1.0 1.0 6 Q9NQT5,Q13868 2 +Regulation of genetic imprinting 0.6198239321812802 0.3242332942619002 0.7457614172517522 1.0 1.0 2 Q13263 1 +Genomic imprinting 0.6198239321812802 0.3242332942619002 0.7457614172517522 1.0 1.0 2 Q13263 1 +Nucleoside triphosphate biosynthetic process 0.3063459026852799 0.3231722332349289 0.7465648082530136 1.0 1.0 33 O75964,P00403,P55263,P00846 4 +Regulation of establishment or maintenance of cell polarity 0.3875367062900714 0.3213669017586676 0.7479323624775964 1.0 1.0 7 Q9H6U6,Q15334,Q9NUQ9,Q13464 4 +Regulation of microtubule based movement 0.4220583985843866 0.320738904053745 0.7484082624362582 1.0 1.0 5 Q7Z4L5,P78318 2 +Regulation of lymphocyte differentiation 0.3251650581422183 0.317903935849124 0.7505578069891186 1.0 1.0 16 P00813,O96005,Q9Y255 3 +L serine transport 0.6023511808771099 0.316426970677575 0.751678448194137 1.0 1.0 3 Q96QD8 1 +Establishment or maintenance of bipolar cell polarity 0.3243893289061508 0.3136329812069003 0.753799807157512 1.0 1.0 16 Q14168,P57105,Q92796 3 +Atp synthesis coupled electron transport 0.3046252681384996 0.3108957931574131 0.7558798426889579 1.0 1.0 38 O43676,O96000,Q9UDW1,P00403 4 +Smooth muscle cell proliferation 0.3215792177694762 0.3094566588880785 0.7569741763559077 1.0 1.0 17 P12956,P09601 2 +Regulation of mrna 3 end processing 0.3191102278431237 0.30878802318239 0.757482780344811 1.0 1.0 18 Q16630,O43865,Q9H2U1,O75150,Q8N684,Q6PJT7,Q5VTR2,Q8N7H5,P18615 9 +Negative regulation of transcription regulatory region dna binding 0.6129768503423484 0.3066748842268867 0.7590908486589605 1.0 1.0 2 P30626 1 +Astral microtubule organization 0.4177545691906089 0.3065317986917441 0.7591997724465638 1.0 1.0 5 Q12959,Q7Z460,Q14974,P15311 4 +Cellular response to extracellular stimulus 0.3000112642992003 0.3056392297114787 0.7598793478835115 1.0 1.0 45 P09601,O95831,P21964 3 +Positive regulation of reactive oxygen species biosynthetic process 0.4171279252048204 0.304482909873415 0.7607600109920745 1.0 1.0 5 P00403 1 +Cerebral cortex cell migration 0.3768300417114265 0.3020118192457253 0.7626430529598103 1.0 1.0 8 Q96N66 1 +Positive regulation of nucleocytoplasmic transport 0.3027776767891005 0.2993350798427102 0.7646843910661878 1.0 1.0 32 P12270,Q9BVS4,Q9Y3B8,Q9NPF5,O00459,P06493,Q9H7Z3,P50402,Q07666,Q14012 10 +Protein acetylation 0.2935484753409675 0.2983359209893081 0.7654467908431102 1.0 1.0 50 O95619,Q86UY6,Q5VZE5,Q01105,P41227,P46379,O75844,Q03164,Q9Y6J9,P16435 10 +Regulation of protein polymerization 0.2704332285320526 0.2980241680032233 0.7656847178986039 1.0 1.0 62 P35080,Q12792,P16949,Q96F07,P35611,O15511,P28289,Q9NYL9,Q16643,Q9UQB8,Q13813,P36404,O00165,Q12959,Q9UEY8,Q16625,P45880,Q01082 18 +Positive regulation of ion transport 0.3027532152160532 0.2966527199338555 0.7667316568974076 1.0 1.0 38 P50570,P14174,O43865,Q96GC9,O14936,P30536,Q12959,O43707,P08183,Q9H4A3 10 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.3988255477617937 0.2960656371839233 0.7671799557240073 1.0 1.0 6 P61978 1 +Positive regulation of cytokinesis 0.3689074487484083 0.2952268890436767 0.7678205624490455 1.0 1.0 9 Q96GD4 1 +Negative regulation of actin filament depolymerization 0.3190069395222672 0.2951229201814436 0.767899981318255 1.0 1.0 17 Q12792,P35611,P28289,Q9NYL9,Q13813,Q01082 6 +Regulation of the force of heart contraction 0.4538144419381651 0.2949666857219829 0.7680193289790163 1.0 1.0 4 P10253 1 +Peptidyl serine dephosphorylation 0.3804702808621788 0.2939760350956322 0.7687762158849463 1.0 1.0 7 Q08209,P63151,P49593,P30153,P62258,P62136 6 +Regulation of nik nf kappab signaling 0.3326208974389731 0.2937183236676529 0.7689731513379152 1.0 1.0 13 O43657,O43707 2 +Regulation of body fluid levels 0.2954764887658855 0.2933395409570313 0.7692626329395007 1.0 1.0 48 Q9UNN8,P35670,P35579,P04062,Q14344,Q99808,Q9Y3B8,P00813,P53582,P00403,Q9H4A3,Q13505,P12814,P15531 14 +Locomotory behavior 0.2989179339687259 0.2921977522194411 0.7701354301489094 1.0 1.0 27 P54802,P10253,P50897,O75844,O15118 5 +Mesenchyme development 0.3022485878532895 0.2910344909023367 0.7710249407580649 1.0 1.0 36 Q9UBV8,O94788,Q92841,Q96A65,P08133,P17844,Q9UK61,Q99729,Q14978,P98172,Q13464 11 +Negative regulation of actin filament polymerization 0.3072286913300506 0.2903640127089822 0.7715377719763983 1.0 1.0 21 P35080,Q12792,P35611,P28289,Q9NYL9,Q13813,Q9UEY8,Q01082 8 +Cellular response to camp 0.4521528764393649 0.2901612244368314 0.7716928990936835 1.0 1.0 4 Q9Y4G8,P27695 2 +Regulation of neuron projection arborization 0.591422204664518 0.2895314868471861 0.7721746881547036 1.0 1.0 3 Q15334 1 +Postsynaptic specialization organization 0.5914022123830571 0.289483335531268 0.7722115305726931 1.0 1.0 3 Q12959 1 +Regulation of dna dependent dna replication initiation 0.4508972267536629 0.2865519663137534 0.7744553978919058 1.0 1.0 4 O60934,P24941,O95251 3 +Organelle disassembly 0.2946026229656229 0.2859156700414514 0.7749427115728058 1.0 1.0 48 Q7Z3C6,Q08379,Q9Y6I9,P30536,Q96HY6,P27544,P21796,P04062 8 +Regulation of endocytic recycling 0.6035213563743123 0.2832778967150157 0.7769638195016535 1.0 1.0 2 Q07960 1 +Peptidyl arginine methylation 0.4486133768352253 0.2800367723182782 0.7794492928483141 1.0 1.0 4 Q86X55,O60678,Q99873 3 +Peptidyl arginine n methylation 0.4486133768352253 0.2800367723182782 0.7794492928483141 1.0 1.0 4 Q86X55,O60678,Q99873 3 +Epithelial tube branching involved in lung morphogenesis 0.601891098793603 0.2793456437572421 0.7799795811903831 1.0 1.0 2 P35222 1 +Response to sterol 0.601891098793603 0.2793456437572421 0.7799795811903831 1.0 1.0 2 Q15126 1 +Response to cholesterol 0.601891098793603 0.2793456437572421 0.7799795811903831 1.0 1.0 2 Q15126 1 +Salivary gland development 0.601891098793603 0.2793456437572421 0.7799795811903831 1.0 1.0 2 P60953 1 +Negative regulation of proteolysis involved in cellular protein catabolic process 0.296141145498411 0.2792514807421267 0.7800518384128696 1.0 1.0 26 P46379,Q96HY6 2 +Maintenance of synapse structure 0.4482058796688117 0.278881062374023 0.7803361022302988 1.0 1.0 4 Q12959,Q14203 2 +Regulation of endothelial cell differentiation 0.3763294603416339 0.2782636983597105 0.780809940552766 1.0 1.0 7 P35611,O75116,Q13464,O14974 4 +Positive regulation of myelination 0.4476345840130349 0.2772642703090479 0.7815771925982342 1.0 1.0 4 Q14118,Q9UPY3,Q8TEW0 3 +Extracellular exosome assembly 0.5851889089458632 0.2747081176101517 0.7835404940734145 1.0 1.0 3 Q92783 1 +Renal tubule development 0.4075631189838034 0.2738511877043502 0.784198984564086 1.0 1.0 5 Q12959 1 +Response to metal ion 0.2790580648069472 0.2723544184737967 0.7853495171224285 1.0 1.0 57 P35670,Q9UBV8,O43865,P09960,Q8TAD4,P35611,P09601,P30536,P02786,Q14168,P50995,O15118,O60888 13 +Regulation of blood circulation 0.2959010049546547 0.2718513906247842 0.7857362886600545 1.0 1.0 27 P00813 1 +Negative regulation of immune system process 0.2977574286354061 0.2701789142140807 0.7870226136936915 1.0 1.0 42 P28070,P14174,Q9UIV1,P09601,P46108,P04439,P00813,Q12959,P19474,Q96IZ0,Q08722 11 +Histone h3 k9 methylation 0.3429993039326796 0.2700520667527765 0.7871201976141173 1.0 1.0 11 P46100 1 +Regulation of superoxide anion generation 0.4450244698205498 0.269929369546603 0.7872145919183409 1.0 1.0 4 P08754,P04899,Q9NY61 3 +Dendritic transport 0.3909130363772359 0.2686575006570763 0.7881932592416896 1.0 1.0 6 P23246 1 +Positive regulation of epithelial cell differentiation 0.373411199533945 0.2673466285143723 0.7892022884624499 1.0 1.0 7 Q9Y3B8 1 +Glycosylation 0.2973296503224551 0.2668464345401395 0.7895874005123911 1.0 1.0 42 O60502,Q2TAA5,Q08379,O75503,Q9BT22,P46977,Q86SF2,O43505,Q9Y5P6,Q8NAT1,P04844,Q10472,O15118,Q8TCJ2,P04843,P04062 16 +Regulation of collateral sprouting 0.5963482230192303 0.2662035843405963 0.7900824226910641 1.0 1.0 2 Q15375 1 +Collateral sprouting 0.5963482230192303 0.2662035843405963 0.7900824226910641 1.0 1.0 2 Q15375 1 +Cellular response to dexamethasone stimulus 0.4050955430217198 0.2661494472082263 0.790124114471366 1.0 1.0 5 P25705 1 +Regulation of immune response 0.2986964747277746 0.2656349493544712 0.7905203665972966 1.0 1.0 116 Q5KU26,Q5RKV6,P12956,Q96PK6,P00813,P46379,O95219,P19474,P02786,Q08722,Q9NQT5,Q9NPR9,P43243,P09601,P46108,Q9NUQ9,Q8WXF1,Q07021,O96028,O15400,P28070,Q9UIV1,P41440,Q9NUD5,P51812,Q9BUI4,Q96IZ0,Q9H4A3,O43657,P23246,Q07666,Q15233,P62942,Q14671,P04439 35 +Cell cycle g2 m phase transition 0.2965423002561885 0.2653458463614226 0.7907430495605372 1.0 1.0 43 P50570,Q96GD4,P06493,O14777,O43823,Q13309,Q9ULX6,Q6NUQ1,P08183,Q9NWV8,Q96K76,Q96JB5,Q07666 13 +Negative regulation of fibroblast proliferation 0.3897199347849809 0.2646025282359021 0.7913156722874561 1.0 1.0 6 Q96IZ0 1 +Aerobic respiration 0.2715905568805914 0.2641883541764165 0.7916347843980944 1.0 1.0 83 Q9UDW1,P25705,O75964,P03915,O43674,P36404,P00846,O43676,P22695,O96000,Q13423,Q15070,P00403,P21912,P48735 15 +Positive regulation of epidermis development 0.3881444831732499 0.2592801048150017 0.7954191287213939 1.0 1.0 6 Q9Y3B8 1 +Positive regulation of epidermal cell differentiation 0.3881444831732499 0.2592801048150017 0.7954191287213939 1.0 1.0 6 Q9Y3B8 1 +Positive regulation of amyloid beta formation 0.5771924263857239 0.2562577125679521 0.7977518477201659 1.0 1.0 3 Q13492 1 +Amyloid beta metabolic process 0.3249356599758016 0.2561822029958324 0.797810150148508 1.0 1.0 13 Q9NQC3,P27695,O95197,P49755,Q13464,Q13492 6 +Positive regulation of monooxygenase activity 0.3860867367475216 0.2523838409695573 0.8007443890028785 1.0 1.0 6 P00374,Q8WTV0 2 +Macroautophagy 0.28714460357963 0.2519196529235048 0.8011031685514345 1.0 1.0 103 Q96CV9,Q96GC9,Q9Y5K8,Q7Z3C6,Q93050,Q9Y487,P09601,Q9Y6I9,Q9UPT5,P56962,Q96HY6,Q86Y82,O15118,P27544,Q8TBX8,P21796,P04062 17 +Positive regulation of double strand break repair via homologous recombination 0.3102730277209821 0.2476989187980448 0.8043673684806458 1.0 1.0 17 O95619,P35637 2 +Dendritic spine maintenance 0.5732241816781873 0.2473426133533835 0.8046430823799018 1.0 1.0 3 Q13614 1 +Embryonic morphogenesis 0.2558945906030855 0.2457626224579266 0.8058659927139453 1.0 1.0 67 P54802,O94788,Q96A65,Q8IZL8,P07942,P25440,Q12959,Q9H4A3,P42892,Q9UK61,Q13464,O15031,O75569,P67809 14 +Cell motility involved in cerebral cortex radial glia guided migration 0.5872187805673239 0.2453361958989483 0.8061961276742609 1.0 1.0 2 Q8WXH0 1 +Gamma aminobutyric acid metabolic process 0.5852624714704988 0.2409924036174471 0.8095610040813337 1.0 1.0 2 O43175 1 +Negative regulation of apoptotic signaling pathway 0.2694847150727673 0.2403271682639261 0.8100766348562229 1.0 1.0 60 P14174,P02545,Q9UL15,P09601,Q8N163,Q9Y255,Q96K76,P45880,Q15233 9 +Positive regulation of lamellipodium morphogenesis 0.5698624931552104 0.2399171758640258 0.8103944652649699 1.0 1.0 3 Q92766 1 +Regulation of lamellipodium morphogenesis 0.5698624931552104 0.2399171758640258 0.8103944652649699 1.0 1.0 3 Q92766 1 +Interferon gamma production 0.3656907243977091 0.2391130308119387 0.8110179376946738 1.0 1.0 7 Q9NUQ9,Q08722,P04439 3 +Amyloid beta formation 0.335848929853294 0.2384004274196235 0.8115705359488479 1.0 1.0 11 Q9NQC3,P27695,O95197,P49755,Q13464,Q13492 6 +Sulfate transport 0.5685486099533782 0.2370469292560125 0.8126203833013346 1.0 1.0 3 Q9UBX3 1 +Cardiac muscle cell proliferation 0.5679297022457677 0.2357011372550532 0.8136645873532158 1.0 1.0 3 P06493 1 +Rrna 3 end processing 0.3807232898938422 0.2347105345693973 0.814433410717204 1.0 1.0 6 Q9NQT5,Q13868 2 +Regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.3348960313417384 0.2342614773403777 0.814781990499442 1.0 1.0 11 Q9UL15,P23246 2 +Positive regulation of cysteine type endopeptidase activity 0.2881472592860027 0.2334976760691319 0.8153749739172231 1.0 1.0 25 O95831,Q96F07,Q96A26,Q9NR28,O00291 5 +Very long chain fatty acid metabolic process 0.3444904860775151 0.2329200501818795 0.81582348879467 1.0 1.0 10 P33121,Q9UKU0,Q15067,Q9P035 4 +Regulation of endothelial cell development 0.3801464644159169 0.2328362288650203 0.815888579377781 1.0 1.0 6 P35611,Q13464 2 +Leukocyte migration 0.2916179726689084 0.2319692426514688 0.8165619030660443 1.0 1.0 44 P35579,P14174,P04062,P09601,P46108,Q8N5M9,P00813,P35613,Q9H4A3,Q08722,Q13464,Q07021 12 +Pattern specification process 0.2912470749066635 0.2307528990914565 0.8175067747857896 1.0 1.0 29 Q7Z4L5,O94788,P29372,O15344,Q9Y2W6,Q9UK61,P98172,O75569 8 +Muscle system process 0.268504050707855 0.2306618128747222 0.8175775424516574 1.0 1.0 60 Q12792,P02545,P06753,P08133,P28289,P09601,P09471,Q9NYL9,P67936,P10253,P00813,P16615,P50402,Q12959,Q14BN4,P60660,Q13464,P46939 18 +Extrinsic apoptotic signaling pathway via death domain receptors 0.3098805585562779 0.2292562457430556 0.818669758676241 1.0 1.0 15 P09601 1 +Vacuolar localization 0.3045310783763337 0.228001758101384 0.8196448737510806 1.0 1.0 18 P35579,O95219,P09601,Q99584 4 +Glucosamine containing compound metabolic process 0.3924315952007169 0.2279845950989013 0.8196582165155641 1.0 1.0 5 O60502 1 +Vasculogenesis 0.3625102962828737 0.2277658094652542 0.8198283081810043 1.0 1.0 7 Q4VCS5,Q96PU8 2 +Cerebellar purkinje cell layer morphogenesis 0.5641083659683523 0.2274808006206453 0.8200498968172656 1.0 1.0 3 Q7Z4L5 1 +Cytoplasmic pattern recognition receptor signaling pathway 0.3093695302654382 0.2267154135391805 0.8206450409069626 1.0 1.0 15 O43657,Q9NUD5,Q14671 3 +Positive regulation of histone h4 acetylation 0.5636329204773054 0.2264687999959899 0.820836822878604 1.0 1.0 3 Q12824 1 +Positive regulation of tyrosine phosphorylation of stat protein 0.5628734389987893 0.2248571817284393 0.8220903803185706 1.0 1.0 3 Q92769 1 +Ribonucleoside monophosphate biosynthetic process 0.3015177801924148 0.2241081452628607 0.8226731546676289 1.0 1.0 19 P00813 1 +Nucleotide binding domain leucine rich repeat containing receptor signaling pathway 0.3909921671018299 0.223795389610418 0.8229165175491369 1.0 1.0 5 P0DMV9,Q96RT1,Q96J02,P98170 4 +Primary mirna processing 0.4273870482651024 0.222669528598217 0.823792718620278 1.0 1.0 4 P22626 1 +Nik nf kappab signaling 0.304634794731099 0.2181765075161821 0.8272915884687533 1.0 1.0 17 O43657,O43707,Q99627 3 +Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.3242617870281947 0.2178438885382566 0.827550747539044 1.0 1.0 12 O60506,Q14103,P67809 3 +Positive regulation of cell adhesion 0.2625524151434784 0.2167311456126096 0.8284178741642902 1.0 1.0 62 P50570,P41440,P30825,P46108,P36404,P46939,P00813,P49366,Q9NUQ9,P02786,P04439,Q08722,P98172,Q13464,O00592 15 +Positive regulation of cell projection organization 0.2600520116878422 0.2157775644606901 0.8291611373253243 1.0 1.0 63 P50570,Q9H6U6,Q14108,P07196,Q9UQB8,Q16625,O15031 7 +Regulation of monooxygenase activity 0.3401689199844747 0.2152979670043247 0.8295350145598019 1.0 1.0 10 P16435,P00374,Q8WTV0 3 +Regulation of translation at synapse modulating synaptic transmission 0.424469820554644 0.2152530514100061 0.8295700311488328 1.0 1.0 4 P35268,P38919,P06730 3 +Postsynaptic modulation of chemical synaptic transmission 0.4244698205546436 0.2152530514100052 0.8295700311488334 1.0 1.0 4 Q08209,P38919,P06730 3 +Negative regulation of leukocyte proliferation 0.3487828427954631 0.2142228785135033 0.8303732557168948 1.0 1.0 9 Q96IZ0 1 +Cellular carbohydrate catabolic process 0.3034441418364995 0.2120582691064965 0.8320615756999024 1.0 1.0 17 Q14108,Q9NUJ1 2 +Regulation of defense response to virus by host 0.3579359895493145 0.2117467148898821 0.8323046411341044 1.0 1.0 7 Q96ST3,Q7Z434,O60828,Q08211,O94826,P42224 6 +Phagocytosis 0.2904875316930013 0.2114102800913814 0.8325671356733964 1.0 1.0 41 Q5KU26,P50570,Q07954,Q8WTV0,P51790 5 +Positive regulation of mrna metabolic process 0.2665052395053738 0.211127232311488 0.8327879908367946 1.0 1.0 60 O15514,P62995,O60506,Q96EP5,Q9NQT5,Q5PRF9,Q13868,Q96E39,P98179,Q13464,Q969T7,Q9UIV1,Q9Y2W1,Q15024,P38159,Q92945,Q14103,Q14671,Q14011,P67809 20 +Negative regulation of epithelial cell migration 0.3478475608878897 0.210634464173666 0.83317251707497 1.0 1.0 9 P57105,P35080 2 +Neutrophil differentiation 0.4219370388654438 0.2089089627916408 0.8345193072421022 1.0 1.0 4 Q8N5M9 1 +Cerebellar cortex formation 0.3856053706243187 0.2083966753020475 0.8349192520702706 1.0 1.0 5 Q7Z4L5 1 +Response to endoplasmic reticulum stress 0.2612826049292789 0.2081851317716703 0.8350844173866916 1.0 1.0 77 O95831,Q9UBU6,P41440,Q13217,Q8TCJ2,O00459,Q96A33,P46379,P16615,Q96HY6,Q7Z2K6,Q96JB5,P32929 13 +Negative regulation of cell killing 0.4209838500588441 0.2065444715986919 0.8363656302322147 1.0 1.0 4 P04439 1 +Regulation of mitotic cytokinesis 0.56863384414737 0.2059266293788859 0.8368482239801223 1.0 1.0 2 Q9Y2S7 1 +Negative regulation of wound healing 0.3716175096291182 0.2057395845198935 0.836994335985505 1.0 1.0 6 O14936 1 +Negative regulation of protein kinase activity by regulation of protein phosphorylation 0.3839822221178426 0.2038441272031304 0.8384753082230321 1.0 1.0 5 Q96JB5 1 +Response to potassium ion 0.419774438015662 0.2035626307519683 0.838695297972404 1.0 1.0 4 Q14168 1 +Cellular response to potassium ion 0.419774438015662 0.2035626307519683 0.838695297972404 1.0 1.0 4 Q14168 1 +Negative regulation of necrotic cell death 0.41957585644371 0.2030749772771434 0.8390764294613262 1.0 1.0 4 Q92974,P12235,P16989 3 +Negative regulation of programmed necrotic cell death 0.41957585644371 0.2030749772771434 0.8390764294613262 1.0 1.0 4 Q92974,P12235,P16989 3 +Regulation of synapse maturation 0.567003586566669 0.2026696657842993 0.8393932343024 1.0 1.0 2 P63104 1 +Negative regulation of cell cycle process 0.2553573233844008 0.2011013555068642 0.8406193221057796 1.0 1.0 71 P12270,Q96GD4,Q96PK6,Q96DY7,Q6IQ49,Q8N163,O14777,P41227,Q12959,Q6NUQ1,Q9NWV8,Q96RU2,P46100,Q96K76,Q96JB5,Q8N6R0,Q08J23 17 +Negative regulation of cell activation 0.2971966937326418 0.2008297509516956 0.8408316989438449 1.0 1.0 19 P09601,Q96IZ0 2 +Regulation of nervous system development 0.2632512102790011 0.2008067562763617 0.8408496797945835 1.0 1.0 61 Q96G23,P07196,Q9UQB8,P30536,P55209 5 +Peroxisome fission 0.4185546079858593 0.2005758493696729 0.8410302437021513 1.0 1.0 4 P40855 1 +Positive regulation of stress activated protein kinase signaling cascade 0.326870335120392 0.2001773292906526 0.841341896934737 1.0 1.0 11 O15344,Q969S3 2 +Negative regulation of cell cycle g2 m phase transition 0.2970428949561871 0.2000120337056387 0.8414711697477766 1.0 1.0 19 Q96GD4,P06493,Q6NUQ1,Q9NWV8,Q96K76,Q96JB5 6 +Nucleoside monophosphate biosynthetic process 0.2885933175368608 0.1992411351893855 0.8420741231853193 1.0 1.0 22 P00813 1 +Positive regulation of bmp signaling pathway 0.4176182707993448 0.1982973933000487 0.8428123910418308 1.0 1.0 4 Q9BRX2,Q14318,Q9C0C9 3 +Mrna cleavage 0.3358651360173942 0.1981242857808702 0.8429478241399118 1.0 1.0 10 Q16630,Q8N684,Q6UN15,Q9UKF6,Q9P2I0 5 +Actomyosin contractile ring organization 0.4174163747992373 0.1978077243236024 0.8431955024517008 1.0 1.0 4 Q15149,Q9H0H5 2 +Neurotrophin trk receptor signaling pathway 0.3689927308934352 0.1976385606463901 0.8433278628081546 1.0 1.0 6 Q99523,Q96F07 2 +Protein localization to adherens junction 0.3815274151436065 0.1970369849411102 0.8437985952755622 1.0 1.0 5 Q07157,Q14160,Q5T2T1,Q13112 4 +Neural precursor cell proliferation 0.2847364127934386 0.1963923775357718 0.8443030619370817 1.0 1.0 23 Q9UKA9,O75306,P55209,Q9UBD5,Q9H0H5,O15031,P48681 7 +Positive regulation of mitochondrion organization 0.2879883876143219 0.195760463665449 0.8447976566936752 1.0 1.0 22 Q96A26,P27544,O14737,P21796 4 +Negative regulation of binding 0.2888185414425748 0.1950469189247367 0.8453562169300763 1.0 1.0 36 P40855,Q96GD4,Q08379,O75381,P09601,P16615,Q13464,Q14012 8 +Regulation of mrna metabolic process 0.3114467597029992 0.193663667725971 0.8464392421448055 1.0 1.0 142 P51114,O43865,P52272,P62995,O60506,P98175,Q9NQT5,Q5PRF9,Q9UHX1,Q13242,O75150,Q9BWF3,P35637,Q13868,Q96E39,P98179,Q13464,Q07021,O75525,Q969T7,Q9UIV1,Q92841,Q9Y2W1,Q96PU8,Q13151,P08670,P38159,Q99729,Q07666,P22626,Q8IY67,Q92945,Q92804,Q14103,Q16629,P61978,Q8N684,Q5VTR2,Q14671,P17844,Q14011,O75494,P67809 43 +Metencephalon development 0.2816509701222616 0.1928575037285646 0.8470705672719627 1.0 1.0 25 Q5KU26,Q7Z4L5,Q14103,P54802,Q9UKA9,O14949,P46108,P04062 8 +Inner ear receptor cell stereocilium organization 0.5469667318982238 0.1925236757025763 0.8473320242576579 1.0 1.0 3 Q9BW83,Q14651 2 +Tetrahydrobiopterin metabolic process 0.4132177384173392 0.1877554465152545 0.8510683630683451 1.0 1.0 4 P61457 1 +Cenp a containing chromatin organization 0.5588522986631802 0.186874820225087 0.8517587819472621 1.0 1.0 2 Q6IPU0 1 +Golgi to vacuole transport 0.3499125725429063 0.1845388397448011 0.8535907606176214 1.0 1.0 7 Q92572,Q99523,O14976 3 +Histone h4 k16 acetylation 0.3409046989727046 0.1845240859204666 0.853602333736178 1.0 1.0 9 O75844 1 +Positive regulation of centriole replication 0.557222041082482 0.1838141779271325 0.854159233277672 1.0 1.0 2 P37198 1 +Regulation of cell cycle g1 s phase transition 0.2861906608454587 0.182733298548661 0.8550072871791861 1.0 1.0 33 Q9UL46,Q8N6R0,Q96DY7,Q96HY6 4 +Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus 0.5559178350179237 0.1813893239006246 0.8560619981762003 1.0 1.0 2 Q9NXV6 1 +Regulation of intrinsic apoptotic signaling pathway 0.2835940005715835 0.1811823424958991 0.8562244538724211 1.0 1.0 46 P14174,P61978,Q9UL15,Q8N163,Q96K76,P23246,P45880,Q15233 8 +Transforming growth factor beta receptor signaling pathway 0.2852512419023376 0.1801761578354793 0.8570142753985999 1.0 1.0 22 P50570,Q92896,P49354 3 +Dna double strand break processing 0.37402088772846 0.1768139781516423 0.8596545090717032 1.0 1.0 5 P51530,Q9NVH0,P49959,P61088 4 +Regulation of neurotransmitter levels 0.2844535993005695 0.1744423202236704 0.861517857417176 1.0 1.0 32 P21964,P50897 2 +Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 0.5520052168242489 0.1742410857544481 0.8616759976000066 1.0 1.0 2 Q92974 1 +Intrinsic apoptotic signaling pathway in response to osmotic stress 0.5520052168242489 0.1742410857544481 0.8616759976000066 1.0 1.0 2 Q92974 1 +Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 0.5520052168242489 0.1742410857544481 0.8616759976000066 1.0 1.0 2 Q92974 1 +Ephrin receptor signaling pathway 0.3460114104317632 0.171734055146517 0.8636466114075094 1.0 1.0 7 P98172,P46108,Q8N5V2 3 +Protein localization to chromosome 0.2830331973327618 0.171361956323678 0.8639391667209013 1.0 1.0 45 Q96GD4,Q96DY7,P46100,Q8NEY8,O14773 5 +Adult behavior 0.293265163670791 0.1697843514098098 0.8651797340096135 1.0 1.0 18 P28289,P50897,O75844,O15118,P51790 5 +Regulation of chromatin assembly or disassembly 0.2974699711485662 0.1696242796326723 0.8653056268649488 1.0 1.0 15 P12270,Q8NEY8 2 +Glucocorticoid metabolic process 0.4042414355628072 0.1671133569808059 0.8672808564527799 1.0 1.0 4 Q9UNE7,P05023,Q04917 3 +Regulation of tissue remodeling 0.335970372880326 0.1665505125254343 0.8677237349673945 1.0 1.0 9 O75116,P02786,Q13464 3 +Neurotransmitter receptor internalization 0.5467883925660215 0.1650051620269104 0.8689399190422384 1.0 1.0 2 Q9UQ16 1 +Postsynaptic neurotransmitter receptor internalization 0.5467883925660215 0.1650051620269104 0.8689399190422384 1.0 1.0 2 Q9UQ16 1 +Apoptotic process involved in morphogenesis 0.5467883925660209 0.1650051620269093 0.8689399190422393 1.0 1.0 2 P30154 1 +Auditory receptor cell morphogenesis 0.5467883925660157 0.1650051620269003 0.8689399190422464 1.0 1.0 2 Q14651 1 +Positive regulation of cell activation 0.2827452043856677 0.1645805415115614 0.8692741479674555 1.0 1.0 44 P14174,Q5RKV6,P30825,P12956,P04439,P00813,P49366,O95219,P02786,Q15418,Q9NQT5,P98172 12 +Positive regulation of defense response to virus by host 0.3578191315703559 0.1644574838949717 0.8693710139177722 1.0 1.0 6 Q96ST3,Q7Z434,O60828,O94826,P42224 5 +Adiponectin activated signaling pathway 0.5292841377233414 0.1598287418883369 0.8730159823684878 1.0 1.0 3 P67870 1 +Neuromuscular junction development 0.3380498148337993 0.1582352999684828 0.8742713887855371 1.0 1.0 8 Q14203,Q9Y4W6,P49354 3 +Forebrain cell migration 0.3333540132414189 0.1572235829382282 0.8750686429375476 1.0 1.0 9 Q96N66 1 +Positive regulation of canonical wnt signaling pathway 0.2945053550158646 0.1560500648868221 0.8759935584928575 1.0 1.0 15 Q96K76,Q7Z4L5,Q8N163 3 +Neuron recognition 0.398522277033936 0.1545744910675916 0.877156781435233 1.0 1.0 4 P35613 1 +Negative regulation of amyloid precursor protein catabolic process 0.3325987100733022 0.1545577321341641 0.8771699943502411 1.0 1.0 9 Q9NQC3,P27695,O95197,Q13464,Q13492 5 +Cellular response to external stimulus 0.2762902619995827 0.1536737066656704 0.8778670175259171 1.0 1.0 50 P09601,O95831,P21964 3 +Foregut morphogenesis 0.5392892076948056 0.1523193696055252 0.8789350484363581 1.0 1.0 2 P35222 1 +Neural plate development 0.5392892076948056 0.1523193696055252 0.8789350484363581 1.0 1.0 2 P35222 1 +Digestive tract morphogenesis 0.5392892076948056 0.1523193696055252 0.8789350484363581 1.0 1.0 2 P35222 1 +Regulation of production of small rna involved in gene silencing by rna 0.3392621298951959 0.1502610440159537 0.8805586663565081 1.0 1.0 7 O75844 1 +Dna methylation dependent heterochromatin assembly 0.323247490327423 0.1500611791341058 0.8807163476732429 1.0 1.0 10 Q8NEY8 1 +Negative regulation of oxidoreductase activity 0.5233257999320857 0.1495951230214489 0.8810840561499569 1.0 1.0 3 Q15070 1 +Protein mannosylation 0.3628379817959308 0.1483883820507854 0.8820362683498668 1.0 1.0 5 Q8NAT1 1 +Collagen fibril organization 0.3306504021982655 0.1477369924281392 0.8825503362264033 1.0 1.0 9 P13674,O75718,Q92791 3 +Positive regulation of neurotransmitter uptake 0.5360286925334142 0.1470208403619081 0.8831155708349727 1.0 1.0 2 P05556 1 +Regulation of neural precursor cell proliferation 0.3072195731552771 0.1460914985034371 0.8838491576246876 1.0 1.0 12 P55209,Q9UKA9 2 +Regulation of epithelial cell differentiation 0.2922803389177105 0.1460410818616805 0.8838889574403566 1.0 1.0 15 Q9Y3B8,P22392,P35611 3 +Protein acylation 0.2701131352510365 0.1453541106115361 0.8844312942217061 1.0 1.0 54 O95619,Q86UY6,Q5VZE5,Q01105,P41227,P46379,O75844,Q03164,Q9Y6J9,P16435 10 +Response to ether 0.5204659073766574 0.1448242656533417 0.8848496229821756 1.0 1.0 3 Q14103 1 +Neurotrophin signaling pathway 0.3373789020358509 0.1444268644269469 0.8851634044496137 1.0 1.0 7 Q99523,P27695,Q96F07 3 +Torc2 signaling 0.5195694716242486 0.143347693740177 0.8860155905816651 1.0 1.0 3 Q9NWS0,Q9Y4R8 2 +Nephron epithelium development 0.3334691074430998 0.1431047834206419 0.8862074272044995 1.0 1.0 8 Q12959,O00592 2 +Regulation of response to wounding 0.2859071089364877 0.1428927396767424 0.8863748926300197 1.0 1.0 19 Q96G23,Q16625 2 +L glutamate transmembrane transport 0.3499836761345148 0.1424943199245714 0.8866895656356784 1.0 1.0 6 O75746,Q9UJS0,Q15041,P05556,O60831 5 +Regulation of protein binding 0.2747608850703096 0.1415657392705348 0.887423030422517 1.0 1.0 50 P10586,Q96GD4,P41440,P62942,Q08379,P35611,O75381,Q9UNE7,P46108,Q07954,Q9BUN8,P16615,P19474,Q13464,Q14012,P48681 16 +Developmental maturation 0.2806364364325431 0.1393412950820509 0.8891804593977302 1.0 1.0 40 O75503,P07196,O94788 3 +Myeloid leukocyte mediated immunity 0.2885637438388395 0.1392735172582807 0.8892340160721883 1.0 1.0 17 O95219,P09601,Q8N5M9 3 +Positive regulation of proteolysis 0.2572955989981342 0.1386326098872776 0.889740473157961 1.0 1.0 80 Q9Y5A7,O95831,O75150,Q96F07,O60826,Q96A26,Q9NR28,O43847,P46379,O14737,Q96HY6,Q9UL46,Q06323,Q96JB5,O00291,Q9Y255,P04062 17 +Cellular response to lipid 0.2715911219216794 0.1382571985215389 0.890037151208487 1.0 1.0 97 O95831,P14174,Q9P253,O94788,Q8WTV0,P08670,O43823,P30536,Q96HY6,O15118 10 +Negative regulation of potassium ion transmembrane transport 0.5156555772994015 0.1370063527712483 0.8910257736810334 1.0 1.0 3 Q96PU5,Q9Y376 2 +Negative regulation of potassium ion transport 0.5156555772994015 0.1370063527712483 0.8910257736810334 1.0 1.0 3 Q96PU5,Q9Y376 2 +Serine family amino acid biosynthetic process 0.3347980283148035 0.1365450596169373 0.8913904056687829 1.0 1.0 7 P00374,P34897,P49903,P32929 4 +Establishment of protein localization to organelle 0.3318777234812575 0.134870927048218 0.8927139263446995 1.0 1.0 181 Q8N4H5,Q99595,P02545,Q9BRG1,Q9NPF5,Q7Z4Q2,Q99567,P55735,P30536,P46379,Q15070,Q9NS69,O14737,Q9Y2T2,Q7Z3B4,Q9Y584,O60830,Q10713,Q9Y5M8,P40855,P12270,Q8N4Q1,Q14108,O75381,O00459,P78371,Q92973,Q8NFH5,P55786,Q14978,O14925,O95831,P62072,P57740,P56589,P52292,Q3ZCQ8,P20645,Q8N1F7,Q99523,Q15629,P06493,O96008,O00165,Q8WWC4,Q5JRX3,Q92783,Q96P70,Q9UII2,O43681 50 +Negative regulation of i kappab kinase nf kappab signaling 0.3466586053773718 0.1335096114404854 0.8937903634900362 1.0 1.0 6 Q96CV9 1 +Sulfur compound catabolic process 0.3304431684428081 0.1333464731584618 0.893919375476989 1.0 1.0 8 P25325,P35610,P16278 3 +Synapse organization 0.2517515550877572 0.1327551681845349 0.8943870110428975 1.0 1.0 63 Q9Y4W6,O00264,P12814,Q14012,P07437,Q15375,P35080,P49354,Q16643,Q9UQB8,O15446,Q14247,Q14203,Q96EV8,Q9H2U1,Q14696,Q15334,Q13614,Q13641,O15031,P10586,O15228,P07196,Q96HC4,Q16352,Q12959,Q8N5V2 27 +Positive regulation of ubiquitin dependent protein catabolic process 0.2735492107356637 0.132617902515215 0.894495573324078 1.0 1.0 23 Q9Y5A7,O60826,Q96HY6,Q96JB5,P04062 5 +Carbohydrate homeostasis 0.2780602213046901 0.1305083870199183 0.89616421901292 1.0 1.0 44 Q15043,P17480,P42785,O00459,Q8N5M9,P49366,P53985,P85037 8 +Primary alcohol metabolic process 0.2832960340204545 0.130123020015815 0.8964690976199425 1.0 1.0 19 O94788 1 +Positive regulation of reproductive process 0.3544386422976552 0.1284176248819407 0.8978184839975651 1.0 1.0 5 P35222,Q92769,Q9H6S0,Q07021 4 +Muscle contraction 0.2781966415138083 0.1282348073699396 0.8979631551554501 1.0 1.0 43 P06753,P08133,P28289,P10253,P09471,Q9NYL9,P67936,P00813,P16615,P50402,Q12959,Q14BN4,P60660,Q13464 14 +Cardiac muscle cell differentiation 0.2960620792759282 0.1281736550463441 0.8980115483088218 1.0 1.0 13 O75844,P06493,Q15149,P02545 4 +Peroxisome organization 0.3171518207760856 0.128131487893978 0.8980449176865348 1.0 1.0 10 O75381,P56589 2 +Synaptic vesicle maturation 0.3856475168047115 0.1281258448701182 0.8980493833609018 1.0 1.0 4 P51790,Q13492 2 +Positive regulation of autophagy 0.2770019961880975 0.1275214158456396 0.8985277241581267 1.0 1.0 32 P09601,O95219,Q96CV9,P27544,Q8TBX8,P21796 6 +Pyrimidine deoxyribonucleoside metabolic process 0.5226605803716875 0.1266636685849571 0.8992066024383376 1.0 1.0 2 P23919 1 +Regulation of protein containing complex disassembly 0.2780826327726305 0.1249347662450375 0.9005751945076463 1.0 1.0 42 Q12792,P35611,P29372,P28289,O15344,Q9NYL9,Q13813,O75844,O95104,Q9UEY8,Q01082,P04062 12 +Rna phosphodiester bond hydrolysis exonucleolytic 0.2716887979279114 0.1225047530675379 0.9024992819430232 1.0 1.0 23 Q9UIV1,Q13868,Q9BQ61,Q9Y3B8,Q9UKF6,Q9NQT5 6 +Regulation of atp metabolic process 0.2772217908826135 0.1220611380821959 0.9028505990014156 1.0 1.0 21 P00403 1 +Regulation of cell projection organization 0.2859682531906396 0.1216911341820025 0.9031436349497646 1.0 1.0 117 Q9NR77,P50570,O14976,Q9NQX7,Q9H6U6,Q14108,Q96G23,Q9UL15,P07196,P08670,Q9UQB8,Q16625,O15031 13 +Response to hepatocyte growth factor 0.3812163612891135 0.1195986984398279 0.9048010508186252 1.0 1.0 4 P48507 1 +Positive regulation of transcription elongation from rna polymerase ii promoter 0.3259965569392685 0.1193555757838578 0.9049936550222604 1.0 1.0 8 Q14004 1 +Negative regulation of double strand break repair via nonhomologous end joining 0.5158134985327567 0.1170794478668565 0.9067970959411602 1.0 1.0 2 Q9UBB9 1 +Nervous system process 0.2686534636005256 0.1166153518753823 0.9071648716958154 1.0 1.0 96 O75569,P62072,Q14108,Q8IZL8,Q6P4Q7,P07196,Q9H6K4,P50897,Q9UQB8,P10253,O75844,O43924,Q9BPW8,Q14168,O14773,P04062 16 +Positive regulation of axonogenesis 0.2844131861557069 0.1153146077005293 0.9081957603305116 1.0 1.0 16 P07196 1 +Lymphocyte chemotaxis 0.5009971654908095 0.1147794557548014 0.9086199333526626 1.0 1.0 3 Q9H4A3 1 +T cell chemotaxis 0.5009971654908095 0.1147794557548014 0.9086199333526626 1.0 1.0 3 Q9H4A3 1 +Protein localization to early endosome 0.347911227154051 0.1137332240360617 0.909449274423771 1.0 1.0 5 O75116,P15311,P35241,Q14160 4 +Regulation of epidermis development 0.3205211266201383 0.1136062279121239 0.90954995015895 1.0 1.0 9 Q9Y3B8,P22392 2 +Organic cyclic compound catabolic process 0.318969645161483 0.1135830764732055 0.9095683035381426 1.0 1.0 164 Q5RKV6,P21964,Q8WTV0,P00813,O60506,P30519,Q08J23,O00584,O60658,P35637,P09601,Q9H773,Q969T7,O95831,Q13126,P08670,Q92945,Q92804,Q14011,P67809 20 +Cytoplasmic sequestering of transcription factor 0.3477706317524885 0.1134250545204048 0.909693577248342 1.0 1.0 5 Q9UNN5,O60826 2 +Negative regulation of adenylate cyclase activity 0.5119008803390819 0.1118554678130065 0.9109380064756074 1.0 1.0 2 P04899 1 +Negative regulation of lyase activity 0.5119008803390819 0.1118554678130065 0.9109380064756074 1.0 1.0 2 P04899 1 +Regulation of vesicle fusion 0.4983692106979658 0.1110477515959611 0.9115784805671518 1.0 1.0 3 O60343,P07355 2 +Positive regulation of cellular protein catabolic process 0.2760481980031397 0.1109584997104893 0.9116492558867192 1.0 1.0 42 Q9Y5A7,O75150,Q07954,P46379,Q96HY6,Q96JB5 6 +Meiosis ii cell cycle process 0.5105966742745235 0.1101546273292608 0.9122867453639903 1.0 1.0 2 P30153 1 +Meiotic sister chromatid cohesion centromeric 0.5105966742745235 0.1101546273292608 0.9122867453639903 1.0 1.0 2 P30153 1 +Negative regulation of mitochondrial fusion 0.4968652477058463 0.1089465512894782 0.9132448837732288 1.0 1.0 3 P02786 1 +Regulation of cellular response to growth factor stimulus 0.2723677240107135 0.1082912709425146 0.9137646466755108 1.0 1.0 30 P50570,Q92896,Q96F07,P62942 4 +Negative regulation of hormone metabolic process 0.5089664166938339 0.1080568864650358 0.9139505674543178 1.0 1.0 2 O60678 1 +Unsaturated fatty acid biosynthetic process 0.3222593759542438 0.1079238826036012 0.914056072190665 1.0 1.0 8 P14174,O15121 2 +Negative regulation of activated t cell proliferation 0.5083143136615464 0.1072265706960348 0.914609236578788 1.0 1.0 2 Q14160 1 +Cellular component maintenance 0.3178996966320035 0.1051467602795123 0.9162593555826204 1.0 1.0 9 Q12959,Q15334,Q07157,Q14203,Q13614 5 +Blastoderm segmentation 0.4931564029549187 0.1038716648639955 0.917271193608022 1.0 1.0 3 Q9UK61 1 +Tripartite regional subdivision 0.4931564029549187 0.1038716648639955 0.917271193608022 1.0 1.0 3 Q9UK61 1 +Maintenance of sister chromatid cohesion 0.3229356883972391 0.1020509273212582 0.918716251896368 1.0 1.0 7 P41227,P46100 2 +Regulation of peptidyl lysine acetylation 0.2783325260858643 0.0991197718448131 0.9210431737296696 1.0 1.0 18 O75844,Q03164,Q01105 3 +Post embryonic development 0.2815114996949775 0.0982405592188876 0.9217412766146666 1.0 1.0 14 P11717,P46100 2 +Positive regulation of mononuclear cell migration 0.3215195216893217 0.0981272250743014 0.9218312693632256 1.0 1.0 7 Q08722,Q9H4A3 2 +Wound healing 0.2562778862462027 0.0979133097541548 0.922001131117407 1.0 1.0 59 Q9UNN8,P42785,P09601,Q8WTV0 4 +Apoptotic process involved in development 0.369004893964113 0.0976358518262827 0.9222214548596388 1.0 1.0 4 O75312,P30154,Q14160 3 +Positive regulation of ion transmembrane transport 0.2666921115244657 0.0960806567656088 0.9234565138884224 1.0 1.0 23 P50570,Q96GC9,O43707,P08183 4 +Positive regulation of cytoplasmic translation 0.294002680290361 0.0957284349346214 0.9237362567920544 1.0 1.0 12 O60506,P67809 2 +Positive regulation of chemokine c c motif ligand 5 production 0.4985327681773603 0.0953672031208626 0.9240231654341128 1.0 1.0 2 Q7Z434 1 +Positive regulation of vesicle fusion 0.4982067166612259 0.0949909087794871 0.9243220480104914 1.0 1.0 2 P07355 1 +Fc epsilon receptor signaling pathway 0.4975546136289427 0.0942419583930273 0.9249169550939264 1.0 1.0 2 P07948 1 +Gdp mannose metabolic process 0.3668418119102152 0.0939805947977284 0.9251245716092396 1.0 1.0 4 Q9Y5P6 1 +Positive regulation of biomineralization 0.4972285621128123 0.093869299626449 0.9252129814754028 1.0 1.0 2 Q4KMQ2 1 +Positive regulation of bone mineralization 0.4972285621128123 0.093869299626449 0.9252129814754028 1.0 1.0 2 Q4KMQ2 1 +Convergent extension 0.4965764590805315 0.0931276080818671 0.925802184661944 1.0 1.0 2 Q13263 1 +Lung associated mesenchyme development 0.4965764590805311 0.0931276080818668 0.9258021846619442 1.0 1.0 2 P35222 1 +Tissue remodeling 0.27678297240845 0.0922463068011978 0.926502347352063 1.0 1.0 18 O14773,P02786,Q92791 3 +Gene silencing by rna 0.273469586026904 0.0922403762029994 0.92650705919595 1.0 1.0 41 Q5KU26,P51114,Q9UIV1,Q9BWF3,Q92841,Q14671,Q15631,Q9H7Z3,O75844,Q9Y2W6,P22626,O75569 12 +Embryonic organ morphogenesis 0.2779068860829057 0.0916838494466567 0.9269492296138832 1.0 1.0 17 Q8IZL8,P54802,O75569 3 +Negative regulation of cell adhesion 0.2716087901745319 0.0914691126277907 0.9271198478800584 1.0 1.0 33 Q9H6U6,O14936,Q12959,O43707,Q9H4A3,Q96IZ0,O15031 7 +Negative regulation of rho protein signal transduction 0.3371409921671062 0.0911259727767868 0.9273924952063042 1.0 1.0 5 P05556,P63167,P16949,Q9NWH9 4 +Regulation of response to reactive oxygen species 0.3060644868807259 0.0905345776003249 0.9278624178130784 1.0 1.0 10 O60658,Q96IZ0 2 +Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway 0.4827136333985523 0.090392251539148 0.9279755138636424 1.0 1.0 3 P04899,P17252 2 +Adrenergic receptor signaling pathway 0.482713633398548 0.0903922515391424 0.9279755138636469 1.0 1.0 3 Q9Y4G8,P04899 2 +Ventricular septum morphogenesis 0.4824583309516443 0.0900775445399129 0.9282255935267788 1.0 1.0 3 O96028 1 +Regulation of intracellular estrogen receptor signaling pathway 0.2787515255578293 0.0886458254195708 0.9293633879950468 1.0 1.0 15 Q96HY6 1 +Positive regulation of lamellipodium assembly 0.2919530937721729 0.0883621239841787 0.9295888641856824 1.0 1.0 12 Q16625 1 +Regulation of fc receptor mediated stimulatory signaling pathway 0.362479608482874 0.0868238442361626 0.9308115342314108 1.0 1.0 4 Q08722,P07948,P41240 3 +Response to interferon gamma 0.2630461438035752 0.086025182814473 0.9314463984367004 1.0 1.0 25 Q9Y5A7,P08670 2 +Establishment of endothelial barrier 0.2749918059652546 0.0844136583532722 0.9327275482500887 1.0 1.0 18 P49327,O14974,P35611,P18206,Q9Y4G8,P35241,P15311,Q9UDY2,Q9H0U4,P55196,P26038,Q8TEU7,Q07157,P62820,Q9Y624,O75116,Q13464 17 +Aspartate family amino acid biosynthetic process 0.2957349392001674 0.0825597333183715 0.9342016200787708 1.0 1.0 11 Q13126 1 +Epidermis morphogenesis 0.4864688620802037 0.0822412458394719 0.9344548750782816 1.0 1.0 2 P35222 1 +T cell tolerance induction 0.4851646560156472 0.0809187032754466 0.935506605677983 1.0 1.0 2 Q96J02 1 +Lymphocyte anergy 0.4851646560156472 0.0809187032754466 0.935506605677983 1.0 1.0 2 Q96J02 1 +Peptidyl arginine methylation to asymmetrical dimethyl arginine 0.4742335290280393 0.0803126421082037 0.935988603746024 1.0 1.0 3 O60678,Q99873 2 +Folic acid containing compound catabolic process 0.4715875695392617 0.0773238844114936 0.9383658907737352 1.0 1.0 3 Q9NRN7 1 +Translational readthrough 0.4812520378219688 0.0770613146717929 0.9385747678689018 1.0 1.0 2 P38919 1 +Intracellular receptor signaling pathway 0.2587282889423876 0.0759045500937157 0.9394950368543332 1.0 1.0 56 O43657,P42785,Q96HY6,O94788 4 +Centrosome duplication 0.2754619675077034 0.0756285305085349 0.939714637397679 1.0 1.0 15 Q9HD42,Q96PK6,P41208,O14777,Q8WUM4 5 +Regulation of fatty acid transport 0.4700509719976196 0.0756219358777797 0.9397198841267872 1.0 1.0 3 P14174 1 +Regulation of cell shape 0.266351144745295 0.0740256379555139 0.9409899850849476 1.0 1.0 30 P35579,Q14344,Q9UQB8,O75844,Q12959,P07686,P35580,O15031 8 +Dephosphorylation of rna polymerase ii c terminal domain 0.477665471144438 0.0736686846533379 0.941274017084829 1.0 1.0 2 Q9NQG5 1 +Golgi disassembly 0.3279922713626266 0.0735225027045223 0.9413903379627644 1.0 1.0 5 Q08379 1 +Negative regulation of guanyl nucleotide exchange factor activity 0.4671477055027162 0.0724734100646395 0.9422251655055952 1.0 1.0 3 P16949 1 +Rna decapping 0.3273466964832706 0.0723359630177373 0.9423345452976452 1.0 1.0 5 Q9BQG2 1 +Methylguanosine cap decapping 0.3273466964832706 0.0723359630177373 0.9423345452976452 1.0 1.0 5 Q9BQG2 1 +Morphogenesis of embryonic epithelium 0.2659571345294169 0.0675362150932102 0.94615483235113 1.0 1.0 21 O15031,O94788 2 +T cell activation 0.2604285716496722 0.0668965698331755 0.946664043799847 1.0 1.0 54 P62942,P30825,P04439,P00813,P49366,Q12959,P02786,O96005,Q96IZ0,Q9Y255,P04062 11 +Positive regulation of lamellipodium organization 0.2730844547465286 0.0664576935011577 0.9470134389052344 1.0 1.0 15 Q16625 1 +Neuroepithelial cell differentiation 0.3487310287696885 0.0661307126589561 0.9472737591971598 1.0 1.0 4 P07437 1 +Regulation of oxidative phosphorylation 0.3186418543911248 0.0660813146655018 0.947313087068022 1.0 1.0 6 Q6L8Q7,P34897,P30405,P14406,Q9BRT2 5 +Gastrulation with mouth forming second 0.3484502446982019 0.0657372847586056 0.9475869876543132 1.0 1.0 4 P35222,Q4VCS5,Q99496 3 +Positive regulation of protein localization to early endosome 0.347797716150081 0.064827443606511 0.9483113905661176 1.0 1.0 4 O75116,P35241,P15311 3 +Regulation of protein localization to endosome 0.347797716150081 0.064827443606511 0.9483113905661176 1.0 1.0 4 O75116,P35241,P15311 3 +Nuclear transcribed mrna catabolic process 0.2614181576081389 0.0647935826062171 0.9483383510535124 1.0 1.0 53 Q969T7,Q9UIV1,Q14103,Q5RKV6,Q13868,Q9Y2W1,P17844,O60506,Q99729,Q9NQT5,Q5PRF9,P67809 12 +Positive regulation of basement membrane assembly involved in embryonic body morphogenesis 0.466905771111831 0.0642886506467517 0.9487403902330374 1.0 1.0 2 Q14118 1 +Regulation of extracellular matrix assembly 0.466905771111831 0.0642886506467517 0.9487403902330374 1.0 1.0 2 Q14118 1 +Positive regulation of extracellular matrix assembly 0.466905771111831 0.0642886506467517 0.9487403902330374 1.0 1.0 2 Q14118 1 +Heart formation 0.4656015650472723 0.063230738346867 0.9495827680844384 1.0 1.0 2 P35222 1 +Iron sulfur cluster assembly 0.2898445718906236 0.0631888818726575 0.9496160980677812 1.0 1.0 11 Q9Y5Y2 1 +Negative regulation of metaphase anaphase transition of cell cycle 0.2715076590472863 0.0621164459448421 0.950470100318705 1.0 1.0 16 P12270,Q96GD4,O14777,P49454,O43670,P25054 6 +Regulation of attachment of spindle microtubules to kinetochore 0.3077012787626213 0.0620835288038152 0.9504963138036012 1.0 1.0 7 Q96GD4 1 +Regulation of proteasomal ubiquitin dependent protein catabolic process 0.267904121779102 0.0606553258345176 0.951633710951767 1.0 1.0 44 Q9Y5A7,Q9UL15,Q8N163,P46379,Q96HY6,P04062 6 +Mitochondrial electron transport nadh to ubiquinone 0.2595504987658935 0.0602576957188588 0.9519503946129771 1.0 1.0 23 O43676,O96000 2 +Positive regulation of hematopoietic progenitor cell differentiation 0.4613628953374614 0.0599068984781777 0.952229785574223 1.0 1.0 2 Q9H2U1 1 +Rna polyadenylation 0.263696302548246 0.0594747754973991 0.9525739561406246 1.0 1.0 30 Q5KU26,Q16630,O43865,O75150,Q8N684,Q6PJT7,Q5VTR2,Q6UN15,Q8N7H5,Q9UKF6,P33240,Q9P2I0,P18615,Q12849 14 +Detection of muscle stretch 0.4600586892728999 0.0589188776623987 0.9530167219705884 1.0 1.0 2 P35222 1 +Synaptic vesicle clustering 0.4600586892728999 0.0589188776623987 0.9530167219705884 1.0 1.0 2 P35222 1 +Organic hydroxy compound biosynthetic process 0.2638211955408844 0.0589137033162506 0.953020843342374 1.0 1.0 50 P37268,Q9H4L5,Q15800,Q13510,P00374,P61457,Q15392,P48449,P04062,Q16850 10 +Ribonucleoprotein complex disassembly 0.3185378590078376 0.0568766550299018 0.9546434507897584 1.0 1.0 5 Q9UBB9,P33176,Q14562,Q07866 4 +Regulation of lipid kinase activity 0.3039814814410424 0.0564739364886264 0.9549642580493048 1.0 1.0 8 Q8TBX8 1 +Neuron cellular homeostasis 0.3413556680600226 0.0561781457677862 0.955199890814252 1.0 1.0 4 P51790 1 +Axo dendritic protein transport 0.3411739294981499 0.055942851636011 0.9553873335916064 1.0 1.0 4 Q14168 1 +Protein localization to presynapse 0.3411739294981499 0.055942851636011 0.9553873335916064 1.0 1.0 4 Q14168 1 +Positive regulation of transmembrane transport 0.2609365874530845 0.055653152103679 0.955618120826685 1.0 1.0 28 P50570,Q96GC9,O43707,P08183,Q16625 5 +Very long chain fatty acid catabolic process 0.3407560628853405 0.0554036472711698 0.9558168902004728 1.0 1.0 4 Q15067 1 +Negative regulation of cytokine production involved in inflammatory response 0.4551679165308064 0.0553560135131254 0.9558548382040934 1.0 1.0 2 Q9BWS9 1 +Regulation of dopamine receptor signaling pathway 0.4484670580560941 0.0542601277050516 0.9567279162116038 1.0 1.0 3 Q96QK1,Q96EV8 2 +Mrna cleavage involved in mrna processing 0.3030296882504436 0.0540028352192073 0.9569329053616132 1.0 1.0 8 Q8N684,Q16630,Q6UN15,Q9P2I0 4 +Regulation of transcription elongation from rna polymerase ii promoter 0.2698081835719907 0.0539189688695549 0.9569997236762222 1.0 1.0 14 O60885,Q15061,Q9NYV4,Q9H3P2,Q14004,Q8IXH7,P18615 7 +L aspartate transmembrane transport 0.447488584474867 0.0534008900424029 0.957412496075138 1.0 1.0 3 Q15758,Q9UJS0 2 +Regulation of cellular extravasation 0.4468362687540619 0.0528331524901571 0.9578648465114534 1.0 1.0 3 Q08722,Q9BX67 2 +Intestinal epithelial cell differentiation 0.4512552983371319 0.0526637719834258 0.957999804717977 1.0 1.0 2 P04818 1 +Intestinal epithelial cell development 0.4512552983371319 0.0526637719834258 0.957999804717977 1.0 1.0 2 P04818 1 +Regulation of hexokinase activity 0.4512552983371221 0.0526637719834194 0.957999804717982 1.0 1.0 2 P49792 1 +Positive regulation of hexokinase activity 0.4512552983371221 0.0526637719834194 0.957999804717982 1.0 1.0 2 P49792 1 +Positive regulation of muscle cell differentiation 0.3036954743471406 0.0524073310218373 0.958204132835593 1.0 1.0 7 P32929,Q14012 2 +Cytoplasmic sequestering of nf kappab 0.3383360522022789 0.052330138627865 0.9582656390571618 1.0 1.0 4 O75832,Q9UNN5,O60826 3 +Positive regulation of deoxyribonuclease activity 0.4448793215916445 0.0511542215556675 0.9592026299591124 1.0 1.0 3 P23396,P12004 2 +Endodermal cell fate commitment 0.3142950391644917 0.04991440107809 0.9601906012081216 1.0 1.0 5 P35222,Q92541,Q8N7H5,Q6PD62 4 +Cell fate commitment involved in formation of primary germ layer 0.3142950391644917 0.04991440107809 0.9601906012081216 1.0 1.0 5 P35222,Q92541,Q8N7H5,Q6PD62 4 +Negative regulation of dendrite morphogenesis 0.4432485322896231 0.0497827449032919 0.9602955172043984 1.0 1.0 3 Q08209,Q9Y4G8 2 +Negative regulation of glial cell apoptotic process 0.444734268014346 0.0484777883442418 0.9613354659586272 1.0 1.0 2 P17252 1 +Regulation of phospholipid translocation 0.4447342680143447 0.048477788344241 0.9613354659586276 1.0 1.0 2 Q9NV96 1 +Negative regulation of homotypic cell cell adhesion 0.4447342680143307 0.0484777883442323 0.9613354659586346 1.0 1.0 2 P35241 1 +Embryonic hemopoiesis 0.313256172160034 0.0482572952443089 0.9615111883340706 1.0 1.0 5 Q03164 1 +Regulation of sister chromatid cohesion 0.2919305110835952 0.0471186344084589 0.9624186757215492 1.0 1.0 10 P23246,P46100 2 +Stem cell differentiation 0.2663438807098984 0.0467777378508861 0.9626903722277916 1.0 1.0 41 Q9UBV8,O94788,O00231,P08133,Q14671,Q13610,Q9Y6C9,Q14978,Q14004,P98172,Q08J23 11 +Physiological cardiac muscle hypertrophy 0.333768352365419 0.0467557942961644 0.9627078615151754 1.0 1.0 4 P49840,Q96HC4,O94826 3 +Actin cytoskeleton reorganization 0.259047901322518 0.0461092354228403 0.9632231850361588 1.0 1.0 22 P35579,Q9H6U6,Q15149,Q9UQB8,O00165,P62993,Q07157,Q14247,Q96EV8 9 +Negative regulation of protein binding 0.256305597315798 0.0444389171613461 0.9645545408666114 1.0 1.0 26 P10586,Q96GD4,Q08379,Q9UNE7,O75381,P16615,Q13464,Q14012,P48681 9 +Lymphocyte migration 0.2970361554854263 0.0435817689060476 0.9652377841939084 1.0 1.0 9 P04062,P46108,Q9H4A3 3 +Negative regulation of cellular component organization 0.3100457319309884 0.0434998132625784 0.965303113381573 1.0 1.0 161 Q9NR77,P04062,O14976,P02545,Q96G23,Q96PK6,Q9NYL9,P30536,P41227,P02786,O00264,P46100,Q9Y255,Q99536,P45880,P12270,P35080,O15212,P16949,Q9H6U6,Q9UL15,P28289,P35611,Q96DY7,Q9NUQ9,Q13464,P50570,Q12792,Q9NYB0,P29372,Q13813,O14777,P08670,O43670,O95104,Q13614,Q01082,Q13492,Q96GD4,Q9NQX7,O15344,Q9UEY8,Q9UHV9,Q8N5V2 44 +Recombinational repair 0.2558222441460089 0.0415484412172342 0.9668586756636096 1.0 1.0 55 O95619,P33991,P35637,Q14566,Q9BRT9,P46100,P23246 7 +Response to chemokine 0.3278121976535447 0.039925353902922 0.9681526377233908 1.0 1.0 4 Q9H4A3 1 +Positive regulation of endothelial cell chemotaxis 0.4268014346266663 0.0387695660849161 0.9690741093299388 1.0 1.0 2 P04792 1 +Regulation of endothelial cell chemotaxis 0.4268014346266663 0.0387695660849161 0.9690741093299388 1.0 1.0 2 P04792 1 +Thrombin activated receptor signaling pathway 0.426940639269387 0.0374025730057716 0.9701640211459036 1.0 1.0 3 P16949,Q13576 2 +Regulation of rac protein signal transduction 0.3056778794518723 0.0367310570985832 0.9706994453614348 1.0 1.0 5 P50570 1 +Fatty acid alpha oxidation 0.4259280021316909 0.036711029066262 0.9707154146488036 1.0 1.0 3 A1L0T0 1 +Regulation of cyclin dependent protein kinase activity 0.2709809856398523 0.0366595193167625 0.9707564858363608 1.0 1.0 13 Q9Y3B8,Q96JB5,Q9P287,P49736 4 +Microvillus assembly 0.3036174674404203 0.0361909195685827 0.9711301263824708 1.0 1.0 6 Q8TEU7 1 +Negative regulation of oxidative phosphorylation 0.4209325073361548 0.0361188176114739 0.9711876178328772 1.0 1.0 2 Q6L8Q7 1 +Regulation of potassium ion transport 0.2645147587627695 0.0354441159740605 0.9717256073344877 1.0 1.0 14 P50570,Q9H4A3 2 +Positive regulation of protein import 0.2617803235823021 0.0348285407556439 0.9722164622007166 1.0 1.0 19 P12270,Q9NPF5,P06493,O00459,O14737 5 +Retinal ganglion cell axon guidance 0.322675367047303 0.0344243889082175 0.972538735458343 1.0 1.0 4 Q13740,O94813,Q15375 3 +Regulation of post translational protein modification 0.4223204067069508 0.0343176319658292 0.9726238648750244 1.0 1.0 3 Q32P28 1 +Cellular response to ether 0.4160417345940671 0.0340908844764169 0.9728046773955864 1.0 1.0 2 P11802 1 +Negative regulation of cellular respiration 0.4210697977821178 0.0335132274594146 0.9732653177703005 1.0 1.0 3 Q12931,Q6L8Q7 2 +Regulation of ribosome biogenesis 0.4137593739810855 0.0331983809075206 0.9735163892609002 1.0 1.0 2 Q5T3I0 1 +Positive regulation of potassium ion transport 0.2925348807716095 0.0316858076035936 0.9747226130962598 1.0 1.0 9 P50570,Q9H4A3 2 +Negative regulation of response to biotic stimulus 0.2608964852016801 0.0313139169137724 0.9750191917589588 1.0 1.0 19 Q9UIV1,P46108,P04439,P19474,O43657,Q07021 6 +Regulation of protein export from nucleus 0.2626826805591307 0.0309451496181186 0.975313282960276 1.0 1.0 17 P12270,P50402,Q9Y3B8 3 +Germ cell proliferation 0.4072383436582935 0.0308282555986178 0.9754065064159784 1.0 1.0 2 Q13162 1 +Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery 0.3189152931721886 0.030621393635966 0.9755714804945316 1.0 1.0 4 P57740,O75694 2 +Regulation of epithelial cell differentiation involved in kidney development 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Metanephric nephron morphogenesis 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Cell differentiation involved in metanephros development 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Metanephric nephron development 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Nephron tubule epithelial cell differentiation 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Positive regulation of mesenchymal cell proliferation 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Mesenchymal to epithelial transition involved in metanephros morphogenesis 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Renal vesicle development 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Metanephric renal vesicle morphogenesis 0.406586240626016 0.0306053971358479 0.9755842378756204 1.0 1.0 2 P35222 1 +Response to extracellular stimulus 0.2489378714485093 0.030506817710757 0.9756628561663194 1.0 1.0 83 O95831,O94788,P09601,P21964,P80303,P30536,Q9UMX5,P53985 8 +Ether biosynthetic process 0.3005874673629317 0.029537434202453 0.9764359637805272 1.0 1.0 5 O00116,Q8WVX9,Q6IAN0,O15228 4 +Regulation of protein import 0.2518538645604358 0.0294838979559786 0.9764786609289452 1.0 1.0 25 P12270,Q9NPF5,O00459,P06493,O14737,Q7Z3B4,Q14978 7 +Trna pseudouridine synthesis 0.4029996739484813 0.0294238277319834 0.9765265692477672 1.0 1.0 2 Q9Y606 1 +Neural tube development 0.2552294579135228 0.0290816559964189 0.976799466004401 1.0 1.0 22 O15031,O94788 2 +Positive regulation of telomere maintenance 0.255690045024317 0.0288754820614224 0.9769638999468716 1.0 1.0 28 Q96GD4,P22626,P78371,P46100 4 +Response to arsenite ion 0.412139247285285 0.0281357229684084 0.9775539025347348 1.0 1.0 3 Q96QD8 1 +Protein o linked glycosylation via serine 0.4116112198303898 0.0278374058665502 0.9777918319465584 1.0 1.0 3 Q7Z4H8,Q10472 2 +Negative regulation of microtubule polymerization 0.3122349102773274 0.0243183534299067 0.9805986735398632 1.0 1.0 4 Q02790,P16949,Q15691 3 +Negative regulation of alcohol biosynthetic process 0.382458428431689 0.0239605525491276 0.9808840741714852 1.0 1.0 2 O75477 1 +Negative regulation of cholesterol metabolic process 0.382458428431689 0.0239605525491276 0.9808840741714852 1.0 1.0 2 O75477 1 +Fear response 0.4041095890410875 0.0238260911509247 0.9809913282255068 1.0 1.0 3 Q04637,P06730 2 +Camp mediated signaling 0.3795239647864352 0.0233413177705363 0.9813780138669084 1.0 1.0 2 Q9Y4G8 1 +Hematopoietic stem cell homeostasis 0.3099510603588929 0.0222934221532522 0.9822138959410802 1.0 1.0 4 Q9NX40,Q14157,P55265 3 +Protein folding in endoplasmic reticulum 0.2887265217197207 0.0220146803100686 0.9824362451820664 1.0 1.0 9 Q13217 1 +Negative chemotaxis 0.3687642647538307 0.0213641094624962 0.9829552035267975 1.0 1.0 2 Q15375 1 +Forebrain neuron differentiation 0.3987860452569117 0.0212275357702977 0.9830641488603176 1.0 1.0 3 O14949 1 +Forebrain generation of neurons 0.3987860452569117 0.0212275357702977 0.9830641488603176 1.0 1.0 3 O14949 1 +Forebrain neuron development 0.3987860452569117 0.0212275357702977 0.9830641488603176 1.0 1.0 3 O14949 1 +Negative regulation of cellular response to insulin stimulus 0.2896144636092984 0.0211952342759171 0.9830899159267256 1.0 1.0 7 Q8TBX8,P05771,Q9HCD5 3 +Dna ligation involved in dna repair 0.3661558526247139 0.0209487253885713 0.9832865578993912 1.0 1.0 2 Q96T60 1 +Regulation of secondary metabolic process 0.3622432344310395 0.0203683464415361 0.983749534490166 1.0 1.0 2 Q9Y4G8 1 +Regulation of nucleotide binding oligomerization domain containing signaling pathway 0.3949771689497674 0.0194889152387425 0.9844510797232684 1.0 1.0 3 Q96RT1,P98170 2 +Activation of immune response 0.2601942707498381 0.0190292703007952 0.9848177553108666 1.0 1.0 47 Q9NUD5,P12956,Q96PK6,P00813,P46379,Q8WXF1,Q96IZ0,Q9H4A3,P23246,Q15233 10 +N glycan processing 0.3926940639269355 0.01849336756652 0.985245268577326 1.0 1.0 3 Q16706,P14314 2 +Tight junction organization 0.2546854634818328 0.0184515975707303 0.985278590526316 1.0 1.0 21 Q16625,P36404,Q8WUM4,Q12959,Q5T2T1,Q07157,P25054,O75116,Q13464,Q15149 10 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.3452885555917835 0.0183739019903959 0.985340572122611 1.0 1.0 2 P23396 1 +Positive regulation of transcription of nucleolar large rrna by rna polymerase i 0.2881411303495619 0.0180972079378459 0.9855613053306412 1.0 1.0 8 P56192,Q9H8H0,Q9NWS0,P19338,Q12824,Q13610,P51532 7 +Protoporphyrinogen ix biosynthetic process 0.3046173349726636 0.0178145627120002 0.9857867872396062 1.0 1.0 4 P36551 1 +Mrna catabolic process 0.2593228373779962 0.0174669979998381 0.9860640606092296 1.0 1.0 97 P51114,P52272,Q5RKV6,O60506,P98175,Q9NQT5,P35637,Q13868,Q13464,Q969T7,Q9UIV1,Q13151,P08670,Q99729,Q92945,Q92804,Q14103,Q14671,P17844,Q14011,Q9BQG2,P67809 22 +Negative regulation of protein localization to cell surface 0.3897586431832915 0.017263308284812 0.9862265569856424 1.0 1.0 3 Q96PU5,Q13492 2 +Chromosome condensation 0.2502377891957974 0.0171698222108301 0.9863011370267368 1.0 1.0 23 O95831,O43823 2 +Vesicle docking 0.2586424419051958 0.0163354906711679 0.9869667438531912 1.0 1.0 17 Q9P253,Q86Y82 2 +Plus end directed organelle transport along microtubule 0.3090968373002985 0.0161364148163192 0.987125562469779 1.0 1.0 2 P33176 1 +Trophoblast cell migration 0.3084447342680154 0.0161133562561715 0.9871439581472116 1.0 1.0 2 Q07021 1 +Regulation of dendritic cell chemotaxis 0.3084447342680154 0.0161133562561715 0.9871439581472116 1.0 1.0 2 Q07021 1 +Motor neuron apoptotic process 0.3002934463645295 0.0158608506260355 0.9873454027454744 1.0 1.0 2 O75312 1 +Dendrite self avoidance 0.2973589827192732 0.0157846279965191 0.9874062119921848 1.0 1.0 2 P35613 1 +Establishment of golgi localization 0.3858447488584371 0.015708114451222 0.9874672534006316 1.0 1.0 3 P63104,P60953 2 +Negative regulation of protein targeting to mitochondrion 0.2905119008803414 0.0156326243429415 0.9875274783976142 1.0 1.0 2 P49257 1 +Regulation of metalloendopeptidase activity 0.2751874796217866 0.0153972141285122 0.9877152859675332 1.0 1.0 2 Q13492 1 +Negative regulation of steroid metabolic process 0.3825831702543967 0.0144838145760918 0.9884439920078808 1.0 1.0 3 O75477,P05023 2 +Negative regulation of establishment of protein localization to mitochondrion 0.3821861950201324 0.0143391390613795 0.9885594143805982 1.0 1.0 3 P31689 1 +Erbb2 signaling pathway 0.3798656211761179 0.0135118674633285 0.9892194176005588 1.0 1.0 3 Q9UNE7 1 +Cyclic nucleotide mediated signaling 0.3796477495107584 0.013435798929398 0.9892801060002674 1.0 1.0 3 Q9H2P0,Q9Y4G8 2 +Schwann cell differentiation 0.2902358857384931 0.0132708948592236 0.989411668681607 1.0 1.0 6 P06493 1 +Response to copper ion 0.2900917129153311 0.0130427038039287 0.9895937230435335 1.0 1.0 6 P35670,P02786 2 +Regulation of ion transport 0.2418623785137458 0.0128314945743692 0.9897622295246536 1.0 1.0 77 P50570,Q96GC9,P14174,O43865,Q8TAD4,P62942,O14936,P30536,O75844,Q12959,O43707,P08183,Q9H4A3,Q14BN4,P21796 15 +Spliceosomal tri snrnp complex assembly 0.272783600404635 0.0126905413905161 0.9898746847370754 1.0 1.0 11 Q9UHI6,O95400,O75494 3 +Nuclear body organization 0.3767123287671194 0.0124372049872861 0.990076801988536 1.0 1.0 3 Q8NC51,O75312 2 +Animal organ morphogenesis 0.2495299602318969 0.0121270560997126 0.9903242463322056 1.0 1.0 86 P53701,P54802,Q7Z3C6,O94788,P62942,O75569,P08133,Q8IZL8,Q6P4Q7,P10253,P07942,O75844,Q15418,Q92896,P16435,P04062 16 +Positive regulation of immune response 0.239997480599327 0.0117260494326785 0.9906441806035072 1.0 1.0 75 Q5RKV6,P12956,Q96PK6,P00813,P46379,O95219,P02786,Q08722,Q9NQT5,P43243,Q9NUQ9,Q8WXF1,Q07021,O96028,Q9NUD5,Q96IZ0,Q9BUI4,Q9H4A3,P23246,Q07666,Q15233,P04439 22 +Regulation of wnt signaling pathway 0.2598051631547121 0.0110082863553308 0.9912168356706524 1.0 1.0 45 Q9H2V7,Q7Z4L5,Q96C57,Q07954,Q8N163,P50402,Q9H4A3,Q96K76 8 +Plasma membrane to endosome transport 0.2948690362744771 0.0104981277491197 0.9916238598086168 1.0 1.0 4 Q99523 1 +Regulation of viral transcription 0.2933115823817323 0.0094290322747792 0.992476832201414 1.0 1.0 4 P19474,Q08211,Q96T23 3 +Organism emergence from protective structure 0.2916802610114204 0.0083376981316851 0.9933475564647354 1.0 1.0 4 Q8IWS0,Q12824,Q6PD62 3 +Secondary metabolite biosynthetic process 0.3623613829093233 0.0082161457599633 0.9934445379033696 1.0 1.0 3 Q9Y4G8,Q9BUT1 2 +Regulation of mrna polyadenylation 0.2617523131342635 0.0081492313396898 0.9934979260988206 1.0 1.0 13 Q16630,O75150,Q8N684,Q5VTR2,P18615 5 +Regulation of metal ion transport 0.2556810398085806 0.0080029558947453 0.9936146332117894 1.0 1.0 51 P50570,Q96GC9,O43865,P62942,O14936,P30536,O43707,Q9H4A3,Q14BN4,P21796 10 +Histone h4 deacetylation 0.3610567514676965 0.007883057598232 0.993710295193617 1.0 1.0 3 Q9H4L7,Q92769 2 +Polyamine biosynthetic process 0.3569055677300921 0.0068749852884272 0.9945145985942871 1.0 1.0 3 Q96QD8 1 +B cell receptor signaling pathway 0.3558382257012384 0.0066281773717797 0.9947115183317332 1.0 1.0 3 P07948,P05771 2 +Positive regulation of cytoplasmic transport 0.2806788511749447 0.0054811448419982 0.9956267010528556 1.0 1.0 5 P26038,Q13614,P35241,P15311 4 +Positive regulation of early endosome to late endosome transport 0.2806788511749447 0.0054811448419982 0.9956267010528556 1.0 1.0 5 P26038,Q13614,P35241,P15311 4 +Regulation of protein secretion 0.2588307041617066 0.0054349601017218 0.9956635505951794 1.0 1.0 38 Q16850 1 +Regulation of amino acid transmembrane transport 0.3496412263535522 0.0052904514213136 0.9957788501821389 1.0 1.0 3 Q15041,P05556 2 +Regulation of l glutamate import across plasma membrane 0.3496412263535522 0.0052904514213136 0.9957788501821389 1.0 1.0 3 Q15041,P05556 2 +L glutamate import across plasma membrane 0.3496412263535522 0.0052904514213136 0.9957788501821389 1.0 1.0 3 Q15041,P05556 2 +Placenta blood vessel development 0.2867862969004898 0.0052344021361101 0.9958235704222148 1.0 1.0 4 P28482,Q15738,Q96T37 3 +Glial cell differentiation 0.257344023095095 0.0051268322189908 0.9959093976464924 1.0 1.0 35 Q7Z4L5,Q07954,P08670 3 +Membrane to membrane docking 0.347684279191122 0.0049004042311348 0.996090058771154 1.0 1.0 3 Q13464,P15311 2 +Endoplasmic reticulum plasma membrane tethering 0.344422700587077 0.0042831016963903 0.996582589732814 1.0 1.0 3 A0FGR8,O95292 2 +Endoplasmic reticulum localization 0.344422700587077 0.0042831016963903 0.996582589732814 1.0 1.0 3 A0FGR8,O95292 2 +Paranodal junction assembly 0.3440965427266769 0.0042235664845324 0.9966300915294966 1.0 1.0 3 O15228,Q9Y2J2 2 +Negative regulation of rig i signaling pathway 0.3424657534246511 0.0039317288415493 0.9968629423424298 1.0 1.0 3 Q8TAT6,Q07021 2 +Peptidyl lysine modification 0.2545230366219698 0.0037707827332307 0.9969913578048964 1.0 1.0 93 Q9H3P2,O95619,P02545,Q92791,Q86UY6,Q01105,P46379,P49366,O75844,Q9BU89,P46100,P32929,Q9Y6J9,P16435,Q03164 15 +Metanephric tubule development 0.3365949119373776 0.0029586729581907 0.9976393239703214 1.0 1.0 3 P35610,P42224 2 +Ketone body metabolic process 0.3365949119373776 0.0029586729581907 0.9976393239703214 1.0 1.0 3 P35610,P35914 2 +Metanephric epithelium development 0.3365949119373776 0.0029586729581907 0.9976393239703214 1.0 1.0 3 P35610,P42224 2 +Steroid esterification 0.3365949119373778 0.0029586729581907 0.9976393239703214 1.0 1.0 3 Q6IAA8,P35610 2 +Ncrna transcription 0.2443725572502431 0.002262407045566 0.9981948618880204 1.0 1.0 24 Q9H2V7 1 +Regulation of synaptic transmission gabaergic 0.328478579856362 0.0017983082089499 0.9985651584178724 1.0 1.0 3 P33176 1 +Potassium ion import across plasma membrane 0.2795603432047759 0.0015849234302228 0.9987354145944064 1.0 1.0 7 Q9H4A3 1 +Secretory granule localization 0.3215916503587736 0.0009644186486156 0.9992305053694042 1.0 1.0 3 P33176,Q12756 2 +Stress granule disassembly 0.3183300717547294 0.0006131015912006 0.9995108157368242 1.0 1.0 3 P33176,Q07866 2 +Establishment of endothelial intestinal barrier 0.274272638117034 0.0003322339927665 0.9997349156314744 1.0 1.0 10 P49327,Q9Y4G8,Q9UDY2,Q9H0U4,P55196,Q8TEU7,Q07157,P62820,Q9Y624 9 +Myoblast differentiation 0.2798279305568375 0.0003130986676508 0.9997501834111552 1.0 1.0 8 P17844,Q92841 2 +Regulation of jun kinase activity 0.2815521239837665 0.0002266066947403 0.9998191940184395 1.0 1.0 6 P23396,Q96EV8,P31689 3 +Rna mediated gene silencing by inhibition of translation 0.2754569190600617 0.0001975538790285 0.9998423748110216 1.0 1.0 5 Q04637,P56537,P26196,Q9BWF3 4 +Regulation of cell cycle checkpoint 0.268021482860978 0.0001178145260228 0.9999059976088656 1.0 1.0 11 P12270,Q8N163,O14777 3 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f4dd14f03c225837d4e87156d2e375cfb8aaa52a --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activation of store operated calcium channel activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult heart development", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid translocation", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp catabolic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide antigen via mhc class ib", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Antral ovarian follicle growth", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome lysosome fusion", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "Bundle of his cell to purkinje myocyte signaling", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp catabolic process", "Camp mediated signaling", "Camp metabolic process", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate import across plasma membrane", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac right ventricle morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine secretion", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell differentiation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cholesterol", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hydroperoxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transmembrane transport", "Copper ion transport", "Copulation", "Coronary vasculature development", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Dehydroascorbic acid transport", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine secretion", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Double strand break repair via synthesis dependent strand annealing", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal cell differentiation", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil mediated immunity", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated inhibitory signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain dorsal ventral pattern formation", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactolipid biosynthetic process", "Galactolipid metabolic process", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center b cell differentiation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import across plasma membrane", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Hard palate development", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula formation", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell migration", "Hematopoietic stem cell migration to bone marrow", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Heparin biosynthetic process", "Heparin metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immature b cell differentiation", "Immune effector process", "Immune response", "Immune response inhibiting cell surface receptor signaling pathway", "Immune response inhibiting signal transduction", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Iodide transport", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte migration involved in inflammatory response", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphocyte migration into lymphoid organs", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Mast cell proliferation", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature b cell differentiation", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane fusion involved in viral entry into host cell", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Midgut development", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotactic protein 1 production", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Mucosa associated lymphoid tissue development", "Mucus secretion", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle atrophy", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immune response to tumor cell", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of behavior", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cell adhesion mediated by cadherin", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular extravasation", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of digestive system process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell apoptotic process", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of feeding behavior", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotactic protein 1 production", "Negative regulation of monocyte chemotaxis", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil activation", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of non canonical wnt signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to microtubule", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor recycling", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of thymocyte apoptotic process", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor 2 signaling pathway", "Negative regulation of toll like receptor 4 signaling pathway", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor mediated signaling pathway", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Olfactory nerve development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Penile erection", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Peristalsis", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phasic smooth muscle contraction", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet degranulation", "Platelet dense granule organization", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of b cell receptor signaling pathway", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle adaptation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cd8 positive alpha beta t cell differentiation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cell adhesion mediated by integrin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of granulocyte differentiation", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide mediated programmed cell death", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle adaptation", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immune response to tumor cell", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phospholipid translocation", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of platelet derived growth factor receptor signaling pathway", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of regulatory t cell differentiation", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secondary metabolite biosynthetic process", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of store operated calcium channel activity", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell differentiation in thymus", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor receptor signaling pathway", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Prepulse inhibition", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Proline transport", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein c linked glycosylation", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c activating g protein coupled receptor signaling pathway", "Protein kinase c signaling", "Protein linear polyubiquitination", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to non motile cilium", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Putrescine metabolic process", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinolinate metabolic process", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagic cell death", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of blood vessel remodeling", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cd8 positive alpha beta t cell differentiation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centromere complex assembly", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of eating behavior", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipid transporter activity", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic nuclear division", "Regulation of melanocyte differentiation", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of mucus secretion", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immune response to tumor cell", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil activation", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil degranulation", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non canonical wnt signaling pathway", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pancreatic juice secretion", "Regulation of pattern recognition receptor signaling pathway", "Regulation of penile erection", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phosphatidylinositol dephosphorylation", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigment cell differentiation", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of store operated calcium channel activity", "Regulation of store operated calcium entry", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 2 signaling pathway", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of voltage gated sodium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cycloheximide", "Response to cytokine", "Response to dexamethasone", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to inactivity", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle inactivity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to stimulus involved in regulation of muscle adaptation", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to yeast", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secondary palate development", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Semicircular canal development", "Semicircular canal morphogenesis", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Store operated calcium entry", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taurine transport", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Tolerance induction to self antigen", "Toll like receptor 2 signaling pathway", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula formation", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by trans synaptic complex", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urate transport", "Urea cycle", "Urea metabolic process", "Ureter development", "Urogenital system development", "Uronic acid metabolic process", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated cholesterol transport", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C3orf58", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COG4", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM162A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL19", "MRPL2", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL41", "MRPL44", "MRPL47", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS27", "MRPS28", "MRPS30", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM161A", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM41B", "TMEM43", "TMEM65", "TMEM70", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSPO", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13D", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFC3H1", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABHD10", "ACBD3", "ACOT8", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSL1", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADK", "ADNP", "AFDN", "AFG3L2", "AGPAT5", "AGPS", "AHCYL1", "AIFM1", "AKAP8", "AKAP8L", "ALCAM", "ALDH1A2", "ALDH1B1", "ALG1", "ALG11", "AMOT", "ANAPC2", "ANO6", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "AP3M1", "AP3S1", "APC", "APEX1", "ARFIP1", "ARHGAP1", "ARHGEF2", "ARL2", "ARL6IP1", "ARPC5", "ASAH1", "ASNA1", "ATAD1", "ATG9A", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP5A1", "ATP5L", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATP7B", "ATPAF1", "ATPIF1", "ATRX", "AURKB", "B4GAT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BCAP31", "BCAS3", "BCCIP", "BDH2", "BICD2", "BRD2", "BRD4", "BSG", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "C3orf58", "CAB39", "CALD1", "CAMK1", "CARM1", "CASK", "CCAR2", "CCDC22", "CCDC47", "CCT2", "CD2BP2", "CD3EAP", "CD47", "CDC42", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKN2AIP", "CENPF", "CENPP", "CERS1", "CERS2", "CETN2", "CHAF1B", "CHCHD3", "CHCHD4", "CHID1", "CHMP1A", "CIRBP", "CLASP1", "CLCN3", "CLN5", "CLPP", "CLPTM1", "CLUH", "CNNM3", "CNNM4", "CNOT2", "CNOT7", "COA3", "COLEC12", "COMT", "COPS2", "COPS8", "COX2", "COX7A2", "CPD", "CPOX", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRK", "CRTAP", "CSK", "CSNK2B", "CSTF2", "CTDSPL2", "CTH", "CTNNB1", "CTNND1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUTA", "CYB5B", "CYFIP2", "CYP51A1", "DAG1", "DAZAP1", "DBN1", "DCTN1", "DCTPP1", "DDB1", "DDRGK1", "DDX17", "DDX20", "DDX5", "DDX6", "DEGS1", "DERL1", "DHCR24", "DHFR", "DHPS", "DHRS7B", "DHX36", "DHX8", "DHX9", "DIABLO", "DICER1", "DLG1", "DLG3", "DMAP1", "DNA2", "DNAJA1", "DNAJC3", "DNM2", "DNM3", "DOCK1", "DOHH", "DSG2", "DTNBP1", "DTYMK", "DYNLL1", "ECE1", "EFNB1", "EHD4", "EIF2S1", "EIF4A3", "EIF4E", "EIF4G1", "EIF6", "EMD", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "ERBIN", "ERLIN1", "ERMP1", "ESYT2", "EXD2", "EXO1", "EXOC3", "EXOC4", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC6", "EXOSC7", "EZR", "F11R", "FAF1", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAR1", "FASN", "FDFT1", "FECH", "FGFR1OP", "FIP1L1", "FKBP1A", "FKBP4", "FKBP8", "FN3KRP", "FNTA", "FOXK1", "FOXRED1", "FUCA1", "FUCA2", "FUS", "FXR1", "GAA", "GAK", "GALNT1", "GALNT7", "GAPVD1", "GATAD2A", "GBA", "GBF1", "GCAT", "GCLM", "GDAP1", "GFM1", "GINS4", "GLA", "GLB1", "GLG1", "GMPPB", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNPAT", "GNS", "GOLGA2", "GOLGA5", "GPATCH4", "GPR107", "GPR108", "GRB2", "GRSF1", "GSK3A", "GTF3C5", "HACD3", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HCCS", "HDAC2", "HDGFL2", "HEATR3", "HEXA", "HEXB", "HGS", "HIP1", "HLA-A", "HLA-C", "HM13", "HMGCL", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPLL", "HNRNPM", "HS2ST1", "HSPA13", "HSPA1B", "HSPB1", "ICMT", "IDH1", "IDH2", "IDH3A", "IFT27", "IGBP1", "IGF2BP2", "IGF2R", "IKBIP", "ILVBL", "IMMT", "INA", "INCENP", "IPO5", "IPO7", "IPO9", "IQGAP2", "ITCH", "ITGB1", "ITM2C", "JAGN1", "JAM3", "KAT7", "KDELC2", "KDM1A", "KDM1B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF1A", "KIF5B", "KIFBP", "KLC1", "KMT2A", "KPNA2", "KPNB1", "LAMB1", "LAMTOR1", "LANCL1", "LARP4", "LARS", "LBR", "LEMD2", "LEMD3", "LGALS3BP", "LLGL1", "LMAN1", "LMNA", "LNPEP", "LPCAT1", "LRP1", "LRRC8C", "LSS", "LTA4H", "LTV1", "LYN", "M6PR", "MAIP1", "MAN2A1", "MAPK1", "MAPRE1", "MARS", "MATR3", 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2.127435347948459e-09 +External side of plasma membrane 8 22 3.209360407487807 0.001330306253741 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.0199420997164649 0.0887403761234401 0.0176675268971412 0.1102835666985419 0.0712576838200765 +Vacuolar lumen 21 61 3.105515319528422 0.0018994778116567 22.262135922330096 63.33980582524272 0.6562244405592584 0.1887666227175413 6.920437110961116 4.902057024259538 2.8947011026985514 0.298290072492813 1.1098310443600944e-07 0.0020388417604097 0.0007339658523063 8.957894550405334e-08 9.136218708724267e-10 +Inner mitochondrial membrane protein complex 27 78 2.955789136766343 0.0031187022732326 27.97087378640777 75.4635922330097 1.520604987560478 0.2664687480104057 12.043574857699111 6.447783897817093 2.3558486082891616 0.3692317407906862 3.6424734744924175e-06 0.0240209396081081 0.0002379711012143 5.604866507348015e-07 1.6478879239082047e-08 +Intrinsic component of mitochondrial membrane 20 50 2.8700261420827173 0.0041043786430117 20.225728155339805 46.883495145631066 1.6360090381123027 0.2606204408334349 9.735582728924424 5.567853242112672 2.0682718238883013 0.3438986948818692 0.0288983202222131 0.0531691841805127 0.0382665496147074 0.0027636692954349 0.000386465762899 +Side of membrane 22 69 2.789346901278605 0.0052814460456687 17.526699029126213 71.19660194174757 0.4235531336200628 0.5236659753791312 6.9409272887607125 8.635706418493163 1.198097658489356 0.36822581052137 0.0746297803054863 0.3282008667955808 0.2073874230966645 0.3868529201769278 0.2270655821308844 +Intrinsic component of mitochondrial inner membrane 16 35 2.77240765774754 0.0055643304179882 13.946601941747574 31.446601941747577 1.7062420859184484 0.2149692261988765 6.992163651608136 3.3601842163433866 1.8185871159494191 0.3070405082296492 0.0061322926620085 0.0230307909848423 0.0115168854492612 0.0066398201592832 0.0005793873081042 +Caveola 2 16 2.729810368593215 0.0063370766193742 2.9466019417475726 14.70873786407767 0.8985606687711867 0.3693669899268542 1.8868639175868975 1.4590265937218798 0.8676345315740439 0.2906359774944637 0.0408464740902213 0.0247821522094747 0.0128121267632092 0.1277697774286049 0.4647625487617958 +Outer mitochondrial membrane protein complex 9 15 2.701701912439652 0.00689855795888 7.157766990291262 15.730582524271844 1.3245491566248977 0.2112996285983387 3.5767402396348245 0.8689557679680192 1.477430451036954 0.2853006280851536 0.002960859746303 0.0901405579438761 0.172526836456327 0.0114205450108361 0.0002717294391002 +Intrinsic component of plasma membrane 36 87 2.5657407870839912 0.0102955735277987 29.711165048543688 79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.0831131873023195 0.8952079263444598 0.2766096714916239 0.151305720961208 0.045904670942814 +Azurophil granule membrane 5 23 2.523006084699708 0.0116356387669658 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 0.0298861159867922 0.019691222561341 0.0695193554582273 0.0238045980839492 0.022687625976848 +Membrane microdomain 8 64 2.500655656716981 0.0123963643849125 14.75485436893204 63.49029126213592 0.5762129399877682 0.5023556315347317 6.545256989336744 6.436953608643344 1.167657055169838 0.3823949317010994 0.024410478807195 0.0128770869665488 0.0098851222249379 0.0942356438284948 0.4667952955865287 +Plasma membrane raft 2 24 2.4581891969102108 0.0139639587170139 3.7766990291262137 20.32281553398058 0.7112808016258366 0.472560537547523 2.42331730763724 2.337985988096463 0.7987766314420426 0.3131348956705554 0.0757041223508513 0.0395283360833688 0.0251129404510266 0.2158850553580524 0.6368286448929202 +Secretory granule membrane 14 72 2.445290137073985 0.0144735654907206 19.699029126213592 69.8495145631068 0.9295860214656708 0.3887665887416008 7.284889203542463 7.49087955205396 1.5950364553562375 0.3903287060113383 0.017416717960672 0.0101766101005315 0.0911394776615091 0.0116765882993715 0.0145978572077083 +Cis golgi network 4 12 2.3945198406724644 0.0166421430304466 5.446601941747573 14.91747572815534 1.304763677188147 0.2415633778835601 2.9087352716231463 3.2280604409731746 1.23405443481851 0.2890539664507128 0.1120281848821345 0.1683799151698467 0.0519022265935445 0.065867090511777 0.0387405426335318 +Organelle envelope lumen 17 39 2.349596707319391 0.0187937613579907 11.436893203883496 36.55339805825243 0.6276066761486734 0.4428242266058088 4.702137301503097 3.7796803567009714 1.1382138566471218 0.3469405856623805 0.1104025890289572 1.0 0.1703695790625126 0.0114639670330544 0.000386465762899 +Apical plasma membrane 17 49 2.288839152960454 0.0220886996724385 13.313106796116504 44.91504854368932 0.8056122914935105 0.4638533528605782 6.08368206230376 5.803837594461636 1.1490032654706197 0.3657186109722784 0.0290882842919351 1.0 0.0617473242092065 0.0850372046250227 0.1444325045504217 +Flotillin complex 0 6 2.281950027644593 0.0224922907527111 2.0606796116504853 6.378640776699029 0.1041367062990808 0.574552005563462 1.8351232133104625 0.5462405468621768 0.8394539663575984 0.2942163844064922 0.1378063248599364 1.0 0.0903020002145616 0.2152011075186096 0.3915613744846742 +Proton transporting two sector atpase complex 5 22 2.267512107501184 0.0233589601243797 7.116504854368932 22.25728155339806 1.0735578367707936 0.2848832687688338 3.2910616544032156 1.9833825153714253 1.32099194967518 0.2987458873835026 0.0014805461500211 1.807613561744718e-05 0.00027562586889 0.0011884258495992 0.0010317596261269 +Proton transporting v type atpase complex 2 11 2.245587162362697 0.0247304635273417 3.1723300970873787 11.17233009708738 1.083137374920517 0.3054753623634815 1.8106779848505148 1.1913569842207026 0.9186852151104662 0.2868810804648729 0.0018241008785546 6.357667188483331e-05 0.000499833948772 0.007181114657122 0.0078256896811826 +Apical part of cell 18 58 2.226611057040716 0.0259732793399209 15.599514563106796 57.72330097087379 0.5629683512109013 0.5412025823450395 6.485031290002554 7.326381428218615 1.086566128273008 0.3654459232984969 0.0719832737451526 1.0 0.1164588558625283 0.1967668443724495 0.2525974483622347 +Schaffer collateral ca1 synapse 4 17 2.224871257836849 0.0260898820226409 3.2888349514563107 15.04611650485437 0.526101921661134 0.5717891227457014 2.2676645532699578 1.9195745549114556 0.7194455680396641 0.3088986439388705 0.1216903305984889 0.1762218760282218 0.3220142659994904 0.0742478127624091 0.0466450280104316 +Proteasome core complex beta subunit complex 6 7 2.2195825890462726 0.0264471152385172 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 0.0072326589819844 1.0 1.0 3.668584180234041e-05 2.80346154767832e-05 +Nuclear inner membrane 12 23 2.186992291437236 0.0287430867371203 7.347087378640777 20.57281553398058 1.3204335588742686 0.2519451141048848 3.6006224195129035 1.9968516080603145 1.2188770932171689 0.2896682474252494 0.1265959661018035 1.0 1.0 0.2661072893157929 0.0149334923888548 +Endocytic vesicle membrane 10 40 2.156152122079384 0.0310717886753402 11.41019417475728 40.75728155339806 0.6528171904926832 0.3529092384633215 4.825015011915381 4.780047567333447 1.5638167276319088 0.3380752375601685 0.0063790319675965 0.0019119564763683 0.021796024792506 0.0186565451910417 0.0084526934355437 +Basolateral plasma membrane 14 46 2.145053272811326 0.0319485878587519 11.907766990291265 41.713592233009706 0.4173504135492652 0.5464661760255546 5.696723454799589 5.533263026209871 1.098008793343998 0.3512755123780914 0.0272236551433306 1.0 0.0942295284993133 0.0062903673188778 0.0036761730132962 +Endocytic vesicle 19 83 2.122744627711411 0.0337752571385006 19.521844660194176 83.27669902912622 0.428513908443532 0.5353120905813061 7.647069906220736 7.607555057832984 1.324058617895936 0.3761698531660883 0.003147468719214 0.0152406110107504 0.0124533618168253 0.0036488004732577 0.0021059207093838 +Tim23 mitochondrial import inner membrane translocase complex 2 7 2.113731359898012 0.0345382184493903 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 0.0004722417385857 0.0011617774889038 0.0001263631731962 0.0019374048420869 0.0013678067399173 +Azurophil granule 24 69 2.080657870897323 0.0374652328052822 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 0.0015097402815418 0.1018269830303097 0.2949514652379627 0.0017238875125103 2.3620282017804656e-06 +Proton transporting two sector atpase complex proton transporting domain 3 10 2.0560867933358216 0.0397741509934268 4.053398058252427 10.283980582524272 1.020958321179617 0.2307004649223604 1.8491832641634656 1.1862626633334956 1.3576055733210162 0.273185751006507 0.0012471501322576 4.282287459858128e-05 0.0003390497899834 0.0003547957514141 0.0048470794580564 +Proteasome core complex 4 15 2.018120904484535 0.0435786710406538 5.325242718446602 14.563106796116504 1.2215341624098188 0.3078540255827756 2.4387733048296822 0.5516067072365743 1.1166106206832802 0.3218631020970666 0.0253021270616913 1.0 1.0 0.0005957243520441 0.0009961752813945 +Endoplasmic reticulum golgi intermediate compartment membrane 6 26 1.9637807153575428 0.0495555274287409 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 0.1937750055582915 0.2291240669446297 0.0945439937832932 0.009902670774728 0.0162593146466844 +Vacuolar membrane 33 120 1.9621764690799024 0.0497419425073648 31.91504854368932 121.20631067961163 0.8693310080509177 0.3422944242486927 10.598363436017626 13.850227259030053 1.9844114292962869 0.3837860427998523 1.0010543813959273e-07 2.271229849514183e-05 1.5129158347286196e-05 4.758394213357276e-07 6.3547757643559735e-06 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e4d2d7a2ecdaa9723d9191d0e250d05ccb641e4d --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 904, + "title": "Average number of proteins per term", + "value": 28.13716814159292 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5f8c41d8351856f1456b8ad3d8ac18659d28e8f5 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cd629dc8311472f9683e448689c310a8303c67aa --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,257 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosomal lumen 0.7245188182762833 3.5731030689868977 0.0003527758250132 0.2730994535943179 0.1594546729059902 32 P07602,O00584,P54802,P16278,Q8IV08,Q14108,P06865,P10253,P50897,Q13510,Q8NHP8,Q9UMR5,P10619,O14773,P04062,P11117 16 +External side of plasma membrane 0.7178206992076894 3.209360407487807 0.001330306253741 0.6998273514117515 0.3006492133454859 22 P41440,P55899,O15439,P00813,P02786,P08183,O96005,P42892 8 +Vacuolar lumen 0.5268853027319826 3.105515319528422 0.0018994778116567 0.8207118216961309 0.343425588347546 61 Q99536,P07602,O00584,Q8IV08,Q14108,P78371,Q13510,P50897,P68371,Q8NHP8,O14773,P11117,P54802,P16278,P06865,P10253,Q9UMR5,Q9BTY2,P10619,P04062,O43681 21 +Inner mitochondrial membrane protein complex 0.4916464245578852 2.955789136766343 0.0031187022732326 0.9406149225920106 0.376111712255783 78 Q9UDW1,Q99595,P25705,Q16891,P00846,Q8IYU8,O96000,P21912,Q9Y584,O60830,Q5HYI7,Q9BPX6,Q9NX63,O43674,P22695,Q96CU9,Q5XKP0,P62072,O75964,O75431,O43676,P00403,Q3ZCQ8,O14949,P03915,Q13505,Q9H4I9 27 +Intrinsic component of mitochondrial membrane 0.562168336162435 2.8700261420827173 0.0041043786430117 0.9757173590983128 0.376111712255783 50 O43819,Q99595,Q16891,Q15070,O60830,Q5HYI7,Q9BPX6,Q9NX63,Q8IWA4,Q9UG56,Q5XKP0,P50336,O14925,Q9Y2R0,O75431,P57105,O96008,Q9H9P8,Q13505,Q9H4I9 20 +Side of membrane 0.4679129016573429 2.789346901278605 0.0052814460456687 0.9916632325516648 0.376111712255783 69 Q14344,Q9NR28,O15439,P00813,P02786,P42892,P51790,P55899,P09471,P10321,P08183,P41440,Q9UBI6,P35579,P62942,P04439,Q12959,O96005,Q9H0H5,P10619,O00291,Q4VCS5 22 +Intrinsic component of mitochondrial inner membrane 0.6042233936190148 2.77240765774754 0.0055643304179882 0.993553394405034 0.376111712255783 35 O43819,Q9NX63,O14925,P50336,Q9Y2R0,Q99595,Q16891,O75431,Q15070,Q9H9P8,Q9UG56,Q13505,Q5XKP0,Q9H4I9,O60830,Q5HYI7 16 +Caveola 0.7081465781338545 2.729810368593215 0.0063370766193742 0.9968074840564334 0.376111712255783 16 P09601,Q8WTV0 2 +Outer mitochondrial membrane protein complex 0.7124949140562167 2.701701912439652 0.00689855795888 0.9980847489421588 0.376111712255783 15 Q9NX63,Q8N4H5,Q8IWA4,Q16891,O75431,Q9NS69,Q13505,Q5XKP0,Q5HYI7 9 +Intrinsic component of plasma membrane 0.4653452136140759 2.5657407870839912 0.0102955735277987 0.9999135065053596 0.4002254787128906 87 Q8TAD4,Q15043,Q9NR28,Q8WTV0,P11717,P02786,O00264,P98172,Q8TDW0,P51790,O00592,Q9UNN8,Q99805,Q92796,P36551,P10321,Q96QD8,P53985,Q9UIQ6,O43813,P41440,P30825,Q9H2J7,P16615,O15121,O43657,Q86UP2,Q14BN4,Q13641,O15031,P20645,P35670,Q07954,P04439,O96005,O15118 36 +Azurophil granule membrane 0.601182136060793 2.5230060846997073 0.0116356387669658 0.9999745880682884 0.4002254787128906 23 P07602,Q9NQX7,P42785,O15260,Q07065 5 +Membrane microdomain 0.4514670284032034 2.500655656716981 0.0123963643849125 0.9999873309885636 0.4002254787128906 64 P41440,P09601,Q8WTV0,P50897,Q86Y82,O15118,O14773,P21796 8 +Plasma membrane raft 0.5802579603975841 2.4581891969102108 0.0139639587170139 0.9999969864275066 0.4072572399616457 24 P09601,Q8WTV0 2 +Secretory granule membrane 0.4407232636067114 2.4452901370739855 0.0144735654907206 0.999998111473546 0.4088782251128585 72 P07602,Q96JJ7,Q8TAD4,Q93050,Q9NQX7,P42785,O15439,P11717,P30519,P10321,O15121,O15260,Q07065,P20073 14 +Cis golgi network 0.7132337444912891 2.3945198406724644 0.0166421430304466 0.9999997422021588 0.4364655979312846 12 Q9NPR9,O95249,Q8TBA6,O00461 4 +Organelle envelope lumen 0.5404204671941633 2.349596707319391 0.0187937613579907 0.999999964411313 0.45388180392891 39 Q9BPX6,O14925,O95831,P50336,O00584,P62072,Q8N4Q1,Q9Y3B8,Q9NR28,Q16891,P36404,Q8IYU8,P11717,P36551,Q9Y255,Q96BR5,P07437 17 +Apical plasma membrane 0.501874369248009 2.288839152960454 0.0220886996724385 0.999999998298954 0.45388180392891 49 O43865,P41440,Q8TAD4,Q15043,Q99808,P30825,O15439,O00165,Q12959,P36551,Q8TEU7,P08183,P53985,Q16625,Q9Y6M7,P51790,O00592 17 +Proton transporting two sector atpase complex 0.5755464599488787 2.267512107501184 0.0233589601243797 0.9999999994746932 0.45388180392891 22 Q8N511,Q93050,O75964,Q9Y487,P00846 5 +Proton transporting v type atpase complex 0.7060119232606694 2.2455871623626975 0.0247304635273417 0.999999999852534 0.45388180392891 11 Q93050,Q8N511 2 +Apical part of cell 0.4575824814705907 2.226611057040716 0.0259732793399209 0.999999999953434 0.45388180392891 58 O43865,P41440,Q8TAD4,Q15043,Q99808,P30825,O15439,P41208,O00165,Q12959,P36551,Q8TEU7,P08183,P53985,Q16625,Q9Y6M7,P51790,O00592 18 +Schaffer collateral ca1 synapse 0.6154930003593364 2.2248712578368495 0.0260898820226409 0.9999999999582108 0.45388180392891 17 Q9BVA1,P07196,Q9UQB8,Q16352 4 +Proteasome core complex beta subunit complex 0.7939255388634976 2.2195825890462726 0.0264471152385172 0.9999999999700062 0.45388180392891 7 P28070,P49720,Q99436,P28072,P49721,P28074 6 +Nuclear inner membrane 0.553791046356069 2.186992291437236 0.0287430867371203 0.9999999999964516 0.4684873328326729 23 Q14728,Q9UH99,P20700,Q14739,P62995,Q9H1E5,Q13185,O75844,P50402,Q8IXM6,Q03252,Q99720 12 +Endocytic vesicle membrane 0.5147340437682374 2.156152122079384 0.0310717886753402 0.9999999999995948 0.4813587237385299 40 Q5KU26,P20645,Q93050,Q14108,Q9Y487,Q07954,Q03519,Q8WTV0,P11717,P10321 10 +Basolateral plasma membrane 0.496466244049177 2.145053272811326 0.0319485878587519 0.9999999999998213 0.4813587237385299 46 P35670,P41440,Q15043,P30825,Q07954,Q92796,O15439,O14936,P57105,Q6P4Q7,Q12959,P02786,P53985,Q14168 14 +Endocytic vesicle 0.4236511523904264 2.122744627711411 0.0337752571385006 0.9999999999999676 0.4908488471880456 83 Q5KU26,Q14C86,Q93050,Q8WTV0,P11717,P02786,P51790,Q14108,Q9Y487,Q03519,P10321,Q16625,O00461,Q86Y82,P50570,P08670,Q8TEU7,P20645,Q07954 19 +Tim23 mitochondrial import inner membrane translocase complex 0.7704735163181686 2.113731359898012 0.0345382184493903 0.999999999999984 0.4908488471880456 7 O60830,Q99595 2 +Azurophil granule 0.4068933467284333 2.080657870897323 0.0374652328052822 0.999999999999999 0.4908488471880456 69 O95721,P42785,P15586,Q99536,O15260,Q07065,P07437,P07602,Q9H7Z7,O00584,P78371,P50995,P68371,P04066,P16278,Q9NQX7,Q13217,P06865,P10253,P06280,Q9BTY2,P10619,Q8NF37,O43681 24 +Proton transporting two sector atpase complex proton transporting domain 0.6957960616413094 2.0560867933358216 0.0397741509934268 1.0 0.4952501545728716 10 Q93050,Q9Y487,P00846 3 +Proteasome core complex 0.5971400752083672 2.018120904484535 0.0435786710406538 1.0 0.5052840266272475 15 P28070,Q99436,P28072,P49721 4 +Platelet dense granule 0.8904011795223182 1.9906422704644595 0.0465202295957474 1.0 0.5052840266272475 4 O15439 1 +Endoplasmic reticulum golgi intermediate compartment membrane 0.5123661533839512 1.9637807153575428 0.0495555274287409 1.0 0.5052840266272475 26 Q96GC9,Q8N511,Q03519,P56962,Q9Y282,O15260 6 +Vacuolar membrane 0.4417391167142692 1.9621764690799024 0.0497419425073648 1.0 0.5052840266272475 120 Q9H2V7,Q93050,Q15043,P42785,Q9Y6I9,P08133,Q8WTV0,Q9Y2T2,P42892,O15260,Q07065,P07602,Q8N511,Q8IV08,Q14108,Q9Y487,P56962,Q9UIQ6,Q16625,Q96GC9,Q7Z3C6,P41440,O75503,O95772,P20645,P11117,Q9P253,Q9NQX7,Q07954,P10253,O15118,P10619,P04062 33 +Cell surface 0.4023174586995718 1.933779296889692 0.0531402693091147 1.0 0.5052840266272475 77 P14174,P25705,O15439,Q8WTV0,P00813,P11717,P02786,P42892,P51790,Q9UNN8,P55899,P09525,O43847,P10321,P08183,P41440,Q13641,O15031,Q99523,Q96JJ7,O96005 21 +Intrinsic component of organelle membrane 0.4454446587503118 1.905328609233783 0.0567373688178949 1.0 0.5052840266272475 131 O43819,O14975,Q99595,Q9Y4W6,Q16891,Q13586,Q9H490,Q96A33,Q15070,P42892,O60830,Q96AQ8,Q5HYI7,Q9BPX6,Q9NX63,Q8IWA4,Q6P4A7,Q8TB61,Q9P2E9,Q03519,Q9P035,O75844,P10321,A0FGR8,Q9UG56,Q5XKP0,P50336,Q86Y82,Q9Y2R0,O14925,Q9UH99,Q6ZRP7,O75431,Q15006,P56589,Q9NXW2,Q9Y282,Q86UP2,Q14739,P51572,Q15629,P57105,Q9NQC3,O43505,O96008,P04439,Q9H9P8,Q13505,O15118,Q9H4I9,Q86XL3,Q9BUN8 52 +Nuclear pore nuclear basket 0.7189632017842419 1.876811842515379 0.0605438867827545 1.0 0.5052840266272475 7 P12270,P41208 2 +Postsynaptic density membrane 0.7185690286480724 1.8749759426414512 0.0607960332373698 1.0 0.5052840266272475 7 Q14168,P57105,Q99720 3 +Mib complex 0.6601169385639422 1.872480766141744 0.0611401204232981 1.0 0.5052840266272475 10 Q9NX63,Q16891,O75431,Q13505,Q5HYI7 5 +Postsynaptic specialization membrane 0.6583362674815472 1.8632255695279707 0.0624305368683921 1.0 0.5052840266272475 10 Q14168,P57105,Q99720,P52292 4 +Uniplex complex 0.8581010218782046 1.8625166403972495 0.0625303021144823 1.0 0.5052840266272475 4 Q9H4I9,Q9BPX6 2 +Pore complex 0.6980935267362359 1.859097340085463 0.0630133422475682 1.0 0.5052840266272475 8 P45880 1 +Basal part of cell 0.4353755118355847 1.7869197725067574 0.0739504562758022 1.0 0.5617748947338251 53 P35670,P41440,Q15043,P30825,P42785,Q92796,O15439,O14936,Q07954,P57105,Q6P4Q7,Q12959,P02786,P53985,Q14168 15 +Postsynaptic specialization intracellular component 0.7689934813203423 1.7696261034252658 0.0767894474131343 1.0 0.5689972168973232 5 Q9UQB8 1 +Striated muscle thin filament 0.8202283849918437 1.7105090752802103 0.0871717766959059 1.0 0.6204983160086532 4 Q9NYL9,P67936,P06753 3 +Myofilament 0.8202283849918437 1.7105090752802103 0.0871717766959059 1.0 0.6204983160086532 4 Q9NYL9,P67936,P06753 3 +Myelin sheath abaxonal region 0.7454429741857727 1.6689369527747906 0.0951298752648148 1.0 0.6615185172260972 5 Q12959 1 +Mcm complex 0.7086236592656661 1.6557731326971512 0.0977677706555146 1.0 0.6695610960044338 6 P33991 1 +Respirasome 0.4404418545283426 1.5826618047821044 0.1134985683862832 1.0 0.6999441872008298 44 Q9UDW1,P03915,O43674,P22695,Q96CU9,O96000,P21912,O43676,Q13423,P00403,Q6DKK2 11 +Phagophore assembly site 0.6556378427844386 1.5777312889464512 0.114627354946138 1.0 0.6999441872008298 7 Q9H6U6,Q96GC9,Q86Y82 3 +Paraspeckles 0.6888114568398965 1.566275448393369 0.1172841461715679 1.0 0.6999441872008298 6 Q15233,P23246,Q8WXF1 3 +Haus complex 0.7840660746319403 1.563807588837014 0.1178627615756471 1.0 0.6999441872008298 4 Q7Z4H7,Q9H6D7 2 +Microbody 0.3984026560498173 1.5513610923603047 0.1208151737988996 1.0 0.6999441872008298 57 Q9NR77,O75381,Q13011,Q15067,P39210,O15254,P08670,P48735,Q9UKU0,Q8N4Q0 10 +Postsynaptic density intracellular component 0.7792981266589525 1.5443684727129026 0.1224990932040972 1.0 0.6999441872008298 4 Q9UQB8 1 +External side of apical plasma membrane 0.9546788392566056 1.5270671245247922 0.126744320826778 1.0 0.7029255584503517 2 P08183 1 +Gtpase complex 0.6420540997051934 1.5125868972780154 0.1303846244825046 1.0 0.7039112668631377 7 Q14344,Q9UBI6,P09471 3 +Proton transporting v type atpase v0 domain 0.9504769572941556 1.4912880974642402 0.135885872533191 1.0 0.7039112668631377 3 Q93050 1 +Vacuolar proton transporting v type atpase v0 domain 0.9504769572941556 1.4912880974642402 0.135885872533191 1.0 0.7039112668631377 3 Q93050 1 +Outer membrane 0.3716321810283775 1.489841149535664 0.1362660085188596 1.0 0.7039112668631377 83 Q8N4H5,Q9BUK6,Q16891,P30536,Q9NS69,O00264,Q99536,P45880,P21796,Q5HYI7,Q9NX63,Q8IWA4,Q9Y277,P09601,Q96TC7,Q6NUM9,Q5XKP0,O43169,Q8NBU5,O75431,Q9UKU0,Q9Y6C9,P57105,O96008,P50402,Q13505,Q99720 27 +Tight junction 0.4477357937711896 1.4695254166769844 0.1416903331314634 1.0 0.7108020522258722 30 Q9NR77,Q16625,Q4VCS5,Q92796,Q9Y4G8,Q9UDY2,Q12959,Q5T2T1,Q8WUM4,P25054,P11802 11 +Phagocytic vesicle membrane 0.4562420876914884 1.4588382872025938 0.1446096218806034 1.0 0.7137049796040256 23 Q93050,Q9Y487,Q03519,P10321 4 +Ficolin 1 rich granule membrane 0.5031853030683602 1.458234850111568 0.144775820902663 1.0 0.7137049796040256 16 Q93050 1 +Endoplasmic reticulum lumen 0.3828071653152408 1.420557526027567 0.1554454337121742 1.0 0.7332923064621002 58 Q32P28,P13674,O00584,Q9Y680,Q13217,Q8IXB1,P07942,O43852,Q9BTY2,Q86UP2,Q02818,O15460,Q07065,Q9NWM8,Q14257,O43681 16 +Ciliary transition zone 0.6560721905488025 1.4171733660983212 0.1564322466878769 1.0 0.7332923064621002 6 A6NIH7 1 +Neurofilament 0.9302022178734478 1.416754684530689 0.1565546627734351 1.0 0.7332923064621002 3 P07196,Q16352 2 +Tim22 mitochondrial import inner membrane insertion complex 0.9237665930560556 1.393086380306496 0.1635936711407066 1.0 0.7584034805702504 3 P62072 1 +Micos complex 0.7396989497760214 1.3822600776540053 0.1668918593053985 1.0 0.7671217165782414 4 Q9NX63,Q16891 2 +Nuclear exosome rnase complex 0.5837272606205006 1.3667552006586683 0.1717020491352112 1.0 0.7722321015832386 9 Q9NQT5,Q5RKV6 2 +Myosin ii complex 0.729284643643097 1.3394835725193257 0.1804132988231446 1.0 0.7878546221105305 4 P60660,P35580 2 +Intrinsic component of golgi membrane 0.5578387957652429 1.328531981348359 0.1840024255696968 1.0 0.7878546221105305 10 Q6ZRP7,Q9Y282,O43505 3 +Microbody membrane 0.4301762660974969 1.3212816647121943 0.1864074652412242 1.0 0.7878546221105305 29 Q9NR77,P40855,O14975,Q9BY49,P33121,O75381,Q8NBU5,P51648,P39210,Q15067,Q9BTZ2,P56589,Q9UKU0 13 +Organelle membrane contact site 0.472771863612587 1.291306993039064 0.1965972467097847 1.0 0.8006074016501535 17 O43865,P51572,O96008,Q96TC7,Q96N66,P56962,Q5XKP0,O95772 8 +Specific granule membrane 0.4657895046053764 1.2810251014976295 0.2001848494667015 1.0 0.8006074016501535 18 Q9Y5K8,P30519,Q07065,O15121 4 +Dendrite cytoplasm 0.5296973724368863 1.2794202908612855 0.2007490922834698 1.0 0.8006074016501535 11 P23246,Q9UQB8 2 +Crd mediated mrna stability complex 0.6251604142296914 1.2753534235207944 0.2021841764485441 1.0 0.8016425241644031 6 P67809 1 +Respiratory chain complex iii 0.5707046661867606 1.2292758478299095 0.2189683995005586 1.0 0.8384951485047093 8 P22695,Q9UDW1 2 +Intraciliary transport particle 0.8676409332456234 1.1869920504037066 0.2352307561997833 1.0 0.8681214961013063 3 Q7Z4L5 1 +Phagocytic vesicle 0.4021430737423617 1.1780735672065674 0.2387672788163646 1.0 0.8681214961013063 41 P50570,Q93050,Q9Y487,Q03519,P08670,P10321,P50995,P51790,Q86Y82 9 +Vacuole 0.4327608178797009 1.1772401458370363 0.2390996692167113 1.0 0.8681214961013063 205 Q9H2V7,Q93050,Q15043,P42785,Q9Y6I9,P08133,Q8WTV0,P00813,Q9Y2T2,P42892,Q99536,Q96CV9,O15260,Q07065,P51790,P07602,Q9UHG3,Q8N511,O00584,Q8IV08,Q14108,Q9Y487,P50897,Q13510,P78371,Q15165,P56962,Q9UIQ6,Q16625,Q8TBX8,P68371,Q96GC9,Q7Z3C6,P41440,O75503,Q8NHP8,O14773,O95772,P20645,P11117,P54802,P16278,Q9NQX7,Q9P253,Q07954,P06865,P10253,Q8NCC3,Q9UMR5,Q9BTY2,O15118,P10619,P04062,O43681 54 +Protein lipid complex 0.8606309847544011 1.16135662863695 0.2454968991009565 1.0 0.8681214961013063 3 Q9UHG3 1 +Centriolar satellite 0.4366699833898374 1.1573449421866526 0.2471314587991722 1.0 0.8681214961013063 20 Q86UY6,P41440,Q9UPT5 3 +Ubiquitin conjugating enzyme complex 0.6825886764781403 1.1475577638046286 0.2511511741715004 1.0 0.8686678788648421 4 Q5VTR2,O75150 2 +Intrinsic component of endoplasmic reticulum membrane 0.3779509262032419 1.1405592038228989 0.2540534023561491 1.0 0.8686678788648421 51 O14975,Q96A33,Q13586,Q9H490,Q8TB61,Q9P2E9,Q03519,Q9P035,O75844,P10321,Q15006,Q9NXW2,Q9Y282,Q86UP2,P51572,Q15629,Q9NQC3,P04439,Q86XL3,Q9BUN8 20 +Clathrin coated vesicle 0.388676041403084 1.1160086698277032 0.2644184235196132 1.0 0.8791192472122473 45 P20645,Q5VW38,Q9P253,Q14108,P11717,P42892,O00291 7 +Platelet alpha granule lumen 0.5002036202925325 1.1115020592128866 0.2663523041802755 1.0 0.8791192472122473 11 Q8NBX0,Q9Y6I9,O43707,P12814 4 +External encapsulating structure 0.4007723871534621 1.1114109608580165 0.2663914964923175 1.0 0.8791192472122473 36 Q5KU26,P07602,Q32P28,P08133,P09525,P07942,O14936,P55081,Q08380,P50995,Q92896,P20073 12 +Mitotic spindle pole 0.4853709650092596 1.1002241713207055 0.271234461514551 1.0 0.884137638596548 12 Q96GD4,Q96DB5,Q9UQE7,Q96TC7,Q8WVM7,Q9P287 6 +Proton transporting atp synthase complex 0.4970125442401335 1.0933168503427912 0.2742547070597105 1.0 0.884137638596548 11 O75964,P00846 2 +Nbaf complex 0.5423292889254712 1.0862497152803603 0.2773685274988211 1.0 0.884137638596548 8 O14497,Q969G3,Q92785 3 +Mitotic spindle microtubule 0.5838898342317189 1.0853649389596138 0.2777600546033403 1.0 0.884137638596548 6 Q7Z4H7,Q9H6D7 2 +Lumenal side of membrane 0.5270977415781561 1.0718378742658616 0.2837928583348887 1.0 0.8899562586076795 9 P10619,P10321,P04439 3 +Dna replication preinitiation complex 0.5100820988705819 1.0688197362011918 0.2851509043775722 1.0 0.8899562586076795 10 Q9BRT9,Q14566,P33991 3 +Lipid droplet 0.3984010052168029 1.059035701249646 0.2895835209095541 1.0 0.8899562586076795 28 Q01105,Q8NBX0,P48449,Q07065,Q99720 5 +Nuclear pore outer ring 0.5342183221591186 1.0453746021773649 0.2958498702945773 1.0 0.8908555961217265 8 P57740,Q8NFH4,P55735 3 +Endoplasmic reticulum golgi intermediate compartment 0.3770491590640188 1.0415748401065656 0.2976088385273909 1.0 0.8908555961217265 47 Q8N511,Q03519,P80303,Q9Y282,Q02818,O15260 6 +Smooth endoplasmic reticulum membrane 0.826540593413756 1.0232733975391817 0.3061785980505651 1.0 0.9015812789501984 2 P56962 1 +Platelet alpha granule 0.4367439690757432 1.0178722833316185 0.3087386549986359 1.0 0.9047314595094692 16 Q96JJ7,Q9Y6I9,O43707,Q8NBX0,P12814 5 +Mitochondria associated endoplasmic reticulum membrane 0.500060498182232 1.014286824608832 0.3104459090411953 1.0 0.9047314595094692 10 Q96N66,O43865,O96008,P56962 4 +Neuromuscular junction 0.4307024257982801 1.0063357915593742 0.3142540689004129 1.0 0.9047314595094692 17 P57105,P07196,Q12959,Q14168,P46939 5 +Cytochrome complex 0.428888590685388 0.9940660740618312 0.3201907006764677 1.0 0.9067475659740984 17 P22695,Q9UDW1,P00403 3 +Acrosomal vesicle 0.4192991832750979 0.993782568728066 0.3203287342312175 1.0 0.9067475659740984 19 P45880 1 +Ciliary basal body 0.4326457890620336 0.9906865643694024 0.3218386536543105 1.0 0.9067475659740984 16 P28070,O43805,Q9UPT5,P41208 4 +Hippocampal mossy fiber to ca3 synapse 0.5896806161331962 0.990406173706152 0.3219756290682363 1.0 0.9067475659740984 5 O60716,Q96EV8 2 +Mhc class i peptide loading complex 0.6367297639462861 0.9603061675313396 0.3369011469257112 1.0 0.9238382279263152 4 Q03519 1 +Snare complex 0.4186879445426685 0.95547524485379 0.3393374182985598 1.0 0.9238382279263152 18 O95721,O95249,Q9P2W9,O95219,P56962,Q99747,Q86Y82 7 +Proton transporting atp synthase complex coupling factor f o 0.5237334922622126 0.9377590904726208 0.3483682291392322 1.0 0.9251254233913576 7 P00846 1 +Nuclear envelope lumen 0.6267687087458799 0.9200323147963854 0.357555872652517 1.0 0.92979212596324 4 P11717 1 +Growth cone membrane 0.7994783175741916 0.919822575595209 0.3576654839287569 1.0 0.92979212596324 2 Q9UPT5 1 +Intrinsic component of nuclear inner membrane 0.5197412063085797 0.9184199013840784 0.3583990755896502 1.0 0.92979212596324 7 Q9UH99,Q14739 2 +Hulc complex 0.7988262145419025 0.9173536386733314 0.358957358364127 1.0 0.92979212596324 2 O75150 1 +Clathrin coated endocytic vesicle membrane 0.4364742691380205 0.8843061425957313 0.376530973273987 1.0 0.9435803899825448 13 P20645,Q14108,P11717 3 +Nadh dehydrogenase complex 0.3753547369295936 0.8816202440349892 0.3779822039117966 1.0 0.9435803899825448 24 O43676,Q96CU9,O96000 3 +Mhc class i protein complex 0.7783012165259064 0.8650005814367399 0.387038469657111 1.0 0.9435803899825448 3 P10321 1 +Mhc protein complex 0.7783012165259064 0.8650005814367399 0.387038469657111 1.0 0.9435803899825448 3 P10321 1 +Synaptonemal structure 0.556468957952547 0.8469657220244047 0.3970142278169986 1.0 0.9492480690767366 5 Q92791 1 +Intermediate filament 0.397272915377734 0.8391538730803294 0.4013829679881171 1.0 0.9492480690767366 19 P02545,P07196,Q16352,P08670,P07197 5 +Prefoldin complex 0.5468193249814902 0.8057875164861577 0.4203653772349143 1.0 0.9492480690767366 5 Q9UHV9 1 +Neurofibrillary tangle 0.760678187153589 0.7753934136695848 0.4381072258153486 1.0 0.9492480690767366 2 P07197 1 +Cleavage furrow 0.4044745095243082 0.7646497430479985 0.4444801401594707 1.0 0.9538226077249636 14 O75935,P35580,Q9H0H5 3 +Endoplasmic reticulum tubular network membrane 0.7567655689599138 0.7611495601310492 0.4465677415020428 1.0 0.9538226077249636 2 Q8NHH9 1 +Transporter complex 0.3142325277453939 0.7551145619806819 0.4501802465077595 1.0 0.9538226077249636 61 Q9UDW1,P62072,P62942,O75381,Q92796,P03915,Q8IYU8,P22695,Q96CU9,O96000,O43676,Q9H4I9,Q8TDW0,Q9C0H2,Q9BPX6 15 +Cell pole 0.7458395179969223 0.7522358050804886 0.4519092650417855 1.0 0.9538226077249636 3 P08195 1 +Cytoplasmic exosome rnase complex 0.450628890873962 0.7478550050334628 0.4545476200225331 1.0 0.9538226077249636 10 Q9NQT5,Q5RKV6 2 +Lumenal side of endoplasmic reticulum membrane 0.4838873808591609 0.7464567504418341 0.4553915484387458 1.0 0.9538226077249636 7 P10321,P04439 2 +Cyclin dependent protein kinase holoenzyme complex 0.4635999292074907 0.7433907126491911 0.4572451654969738 1.0 0.9538226077249636 9 Q14004,Q9P287,P49736,P06493 4 +Sarcolemma 0.3591257762153601 0.7388898540857884 0.459973883703594 1.0 0.9538226077249636 29 P41440,P35613,Q96QD8,Q12959,P24666,Q14BN4,Q15149,P46939 8 +Microbody lumen 0.3753440599829076 0.7178032165672902 0.4728786297963245 1.0 0.9690254022992182 20 P34913,O14734,Q13011,O15254,Q15067,Q9BQG2 6 +Dendritic shaft 0.5248452097082709 0.7132106939607067 0.4757153898578599 1.0 0.9690254022992182 5 Q9UQB8 1 +Brush border membrane 0.4670512705419494 0.7109279578017992 0.4771288800664335 1.0 0.9690254022992182 8 P40855,Q14728,P41440 3 +Golgi medial cisterna 0.7330982128069758 0.708941311511552 0.4783608973684004 1.0 0.9690254022992182 3 O95249 1 +Rpap3 r2tp prefoldin like complex 0.475614387552688 0.7073954354597902 0.4793207727138537 1.0 0.9690254022992182 7 O15212,Q9UHV9 2 +Chromosome passenger complex 0.7243795076930619 0.6796842557932635 0.4967044071208899 1.0 0.9890325639587764 3 Q96GD4 1 +Prespliceosome 0.4597314025734035 0.6753641263610748 0.4994444513845595 1.0 0.9923028220915204 8 P08621,O75400 2 +Spindle pole centrosome 0.4663683402509312 0.6641144849194426 0.5066170400240235 1.0 0.9999602711391208 7 Q96GD4,Q9Y5Y2 2 +Extrinsic component of cytoplasmic side of plasma membrane 0.370698592683911 0.6559313331474667 0.511868306762655 1.0 1.0 19 Q14344,P09471,Q9UBI6,P29992,A0FGR8,Q15334,Q9H0H5,O00291 8 +Respiratory chain complex iv 0.4326836796530291 0.6533311070538235 0.5135428423566901 1.0 1.0 10 P00403 1 +Golgi cis cisterna 0.7225301597652507 0.6396699543286651 0.5223871928315842 1.0 1.0 2 Q08379 1 +Anchored component of plasma membrane 0.722530159765238 0.6396699543286222 0.5223871928316122 1.0 1.0 2 P36551 1 +Smooth endoplasmic reticulum 0.4110994754923165 0.6117602532680657 0.540696390519404 1.0 1.0 11 P56962,Q14BN4,Q13217 3 +Lateral element 0.7137267688294751 0.6094738864799651 0.5422103765224922 1.0 1.0 2 Q9NQS7 1 +Mitochondrial protein containing complex 0.3616279476658938 0.6060088322078647 0.5445088882704474 1.0 1.0 163 Q7Z7F7,Q8N4H5,Q9UDW1,Q99595,P25705,Q9Y291,P00846,Q8IYU8,O96000,Q9NS69,Q9Y584,O60830,P21796,Q5HYI7,Q9BPX6,Q567V2,Q7Z7H8,Q8IWA4,Q96CU9,O14874,P62072,O75964,O43676,P00403,P03915,Q13505,Q9H4I9 27 +Organelle inner membrane 0.407616195097546 0.6001920355184872 0.5483782609549948 1.0 1.0 250 Q9H2V7,Q7Z7F7,Q9UDW1,Q99595,O43772,P25705,P22830,P39210,Q9Y291,P00846,Q8IYU8,O96000,Q8IXM6,Q9Y584,O60830,Q5HYI7,Q9BPX6,Q567V2,Q7Z7H8,Q9H061,P22695,Q96CU9,O75844,Q8NI60,Q03252,Q70HW3,Q9Y2R0,O95831,O75600,P62072,O75964,O75027,O75431,O43676,Q13423,P00403,P53701,Q69YU5,Q9UDX5,P03915,P23786,Q9H1E5,Q8WWC4,Q9H9P8,Q13505,Q9BQT8,Q9UBX3,Q9H4I9,Q6DKK2,Q99720 50 +Collagen containing extracellular matrix 0.3414856676986637 0.59665065663183 0.550740642939572 1.0 1.0 30 P07602,Q32P28,P08133,P09525,P07942,O14936,Q08380,P50995,P20073 9 +Exoribonuclease complex 0.3729377947792056 0.5852457928870397 0.5583824578363068 1.0 1.0 15 Q9NQT5,Q5RKV6 2 +Clathrin coated endocytic vesicle 0.3626513400109917 0.5773608822130254 0.5636956936929862 1.0 1.0 18 P50570,Q14108,P11717,P20645 4 +Endoplasmic reticulum plasma membrane contact site 0.7039452233452882 0.5764943778327312 0.5642810689143392 1.0 1.0 2 A0FGR8 1 +Myosin filament 0.6911007456681226 0.5712269787476636 0.5678457925932494 1.0 1.0 3 P35580 1 +Npbaf complex 0.4351519111401353 0.5582169993259565 0.5766962141581424 1.0 1.0 8 Q969G3,Q92922,O14497,Q12824,Q96GM5,P51532,Q8TAQ2 7 +Intrinsic component of postsynaptic density membrane 0.6977502445386382 0.5559378260572644 0.5782533585907979 1.0 1.0 2 Q15334 1 +Calcium channel complex 0.4207024809059971 0.530262940693509 0.5959296373920915 1.0 1.0 9 Q9BPX6,Q9H4I9,Q8IYU8 3 +Oligosaccharyltransferase complex 0.4287272037251432 0.5282971586124973 0.5972931034337376 1.0 1.0 8 P46977,Q8TCJ2,P04843 3 +Pigment granule 0.2877252664509534 0.5188573011487536 0.6038602555802615 1.0 1.0 63 P41440,Q93050,P08133,O43852,P02786,P55209,O14773 7 +Histone pre mrna 3 end processing complex 0.6738512657982596 0.5173477761369287 0.6049134085544772 1.0 1.0 3 P67809 1 +Nuclear cyclin dependent protein kinase holoenzyme complex 0.669464454117208 0.5039353368118717 0.6143068177213395 1.0 1.0 3 Q14004 1 +Golgi membrane 0.3235275249172171 0.4886353379717033 0.6250998900849656 1.0 1.0 123 Q08379,Q9P2W9,P11717,Q96CV9,Q8IZA0,O15260,P51790,Q7LGA3,Q10713,Q9H7Z7,Q9H3P7,Q8IV08,Q8TB61,Q14108,O95249,P10321,Q15392,O00461,Q86Y82,P50570,Q7Z3C6,Q6ZRP7,Q86SF2,P52292,Q9Y282,P35670,Q8TBA6,O43505,P04439,O95197,Q92896,Q8NF37 32 +Mitochondrial crista 0.5132137030994965 0.4862199980789938 0.6268111940212575 1.0 1.0 4 P07948,O60313,P18031 3 +Extrinsic component of synaptic membrane 0.466110912705218 0.4781980147796363 0.6325092753663091 1.0 1.0 5 O00291,P52292 2 +Extrinsic component of postsynaptic membrane 0.5105848207862416 0.4770553031225132 0.6333227415494231 1.0 1.0 4 O00291 1 +Mrna cleavage factor complex 0.3728259631809034 0.4558097476916485 0.6485267939680404 1.0 1.0 12 Q5KU26,Q16630,Q8N684,Q6UN15,Q9UKF6,Q9P2I0 6 +Sorting endosome 0.6625366807955628 0.4445613112552465 0.6566368118571313 1.0 1.0 2 Q07960 1 +Pericentric heterochromatin 0.3905865565166912 0.4408198107679367 0.6593434503130431 1.0 1.0 10 P46100,P07199,Q9NQS7,Q13185 4 +Coated vesicle 0.2890098372967235 0.4240357634802639 0.6715397314218357 1.0 1.0 87 P20645,P50570,Q9UBV8,Q5VW38,Q8N511,Q9P253,Q99523,Q08379,Q14108,P11717,P10321,P56962,P02786,P42892,Q9Y282,O00291 16 +Intrinsic component of mitochondrial outer membrane 0.3749159437754951 0.4225014791534574 0.6726590212919292 1.0 1.0 11 P57105,Q8IWA4,O96008,Q8IXI1 4 +Lamin filament 0.6397287194868704 0.416488232220749 0.677052776652278 1.0 1.0 3 P02545 1 +Ciliary tip 0.4107011019863526 0.4157603798391003 0.6775853534803491 1.0 1.0 7 Q7Z4L5 1 +Nucleotide activated protein kinase complex 0.6369242211103949 0.4085768971232902 0.6828501878830728 1.0 1.0 3 P13861 1 +Early endosome membrane 0.3128244865844916 0.405592028135904 0.6850423872419622 1.0 1.0 44 Q7Z3T8,Q15043,O95219,P51790,Q8IV08,Q9NV96,P10321,P61020,Q86Y82,O15400,O60749,Q15334,Q9H223,Q13614,Q9UJY4,O14964,A4D1P6,P04439,Q9Y5X3,P42566,P61106,Q92783,P20339 23 +Nuclear outer membrane 0.3817548507283542 0.3985491565097545 0.6902254312113354 1.0 1.0 10 Q6NUM9,Q99720 2 +Autophagosome 0.3131087071376842 0.3915704163561612 0.6953756501394617 1.0 1.0 27 Q96GC9,Q7Z3C6,Q9P253,Q9Y6I9,P56962,Q8TBX8 6 +Autophagosome membrane 0.340984427926944 0.3859076675511512 0.6995650517947465 1.0 1.0 14 Q96GC9,P56962,Q9Y6I9 3 +Endoplasmic reticulum palmitoyltransferase complex 0.64199543527877 0.3844695708151979 0.7006304450300189 1.0 1.0 2 O15269 1 +Palmitoyltransferase complex 0.64199543527877 0.3844695708151979 0.7006304450300189 1.0 1.0 2 O15269 1 +Neuron projection terminus 0.3352026867924417 0.374351732980066 0.7081426480146837 1.0 1.0 16 P51790,O75150,O75494,Q9UQB8 4 +Gamma secretase complex 0.6364525595043974 0.368941876074752 0.7121710491844158 1.0 1.0 2 P49755 1 +Golgi cisterna 0.3288618732396436 0.3657956182305667 0.7145175897716372 1.0 1.0 18 Q99523,Q08379,O95249,Q8TBA6,P04439,O00461 6 +Lateral plasma membrane 0.31914869791517 0.3648454149217722 0.7152268021626007 1.0 1.0 21 Q12959,P36404,P53985 3 +Cortical endoplasmic reticulum 0.6209817894348428 0.3648091296209593 0.7152538896499814 1.0 1.0 3 P50402 1 +Prp19 complex 0.3728430979985102 0.3569432605281711 0.7211342828047187 1.0 1.0 10 O75934 1 +Sin3 complex 0.6131767775603315 0.3441635491069062 0.7307232932931249 1.0 1.0 3 Q9UBU8,Q92769 2 +N terminal protein acetyltransferase complex 0.4692509617215948 0.3411603257234392 0.7329828889559018 1.0 1.0 4 Q5VZE5 1 +Clathrin coated vesicle membrane 0.3065156723186124 0.3332895533686448 0.738915724253391 1.0 1.0 23 P20645,Q14108,P11717,O00291 4 +Nuclear pore central transport channel 0.4654321098842953 0.3294786203654622 0.7417939511511338 1.0 1.0 4 Q7Z3B4 1 +Condensed nuclear chromosome 0.3226742804026486 0.3293686168415856 0.7418770857599586 1.0 1.0 18 O60885,Q9HD42,Q9NQS7,Q92791,Q9UQE7,Q9UEY8,Q9H6R4 7 +Acrosomal membrane 0.6168894685360338 0.3166459177661502 0.7515122898720661 1.0 1.0 2 P35613 1 +Intrinsic component of presynaptic membrane 0.4603588907014617 0.3142146217734761 0.7533580381085663 1.0 1.0 4 P27824,Q92542,P20020 3 +Spectrin 0.4182333907573378 0.308100766393604 0.7580056580808314 1.0 1.0 5 Q01082,Q13813 2 +Nuclear periphery 0.2686493719232951 0.2793322376883124 0.7799898683968753 1.0 1.0 62 P12270,Q8N1F7,O95619,Q5BKZ1,P02545,O14936,O43823,P08670,Q9ULX6,Q8WVM7,Q8WXF1,P23246,P22626,Q15233 14 +Pcg protein complex 0.3708043452505904 0.2779927517755782 0.7810179227913583 1.0 1.0 8 Q8IXK0,Q14157,Q9UQR0,Q92769 4 +Juxtaparanode region of axon 0.5860441802533221 0.2767193850173545 0.7819955858141174 1.0 1.0 3 Q14168 1 +Extrinsic component of endosome membrane 0.5853505173829211 0.2750876022503764 0.7832489362510979 1.0 1.0 3 A4D1P6 1 +Intermediate filament cytoskeleton 0.298331199302129 0.2708268513495051 0.7865242069965037 1.0 1.0 31 P02545,Q9H6U6,P07196,P08670,Q16352,P07197 6 +Zymogen granule 0.444371941272429 0.2681090200681543 0.7886154029251444 1.0 1.0 4 P49755,P08754,O15126 3 +Azurophil granule lumen 0.2970780410390377 0.2610516026657346 0.7940527133113968 1.0 1.0 41 Q9H7Z7,O00584,P16278,Q13217,O43681,P06280,P78371,P04066,Q9BTY2,P15586,Q99536,P10619,P68371,P07437 14 +Gemini of coiled bodies 0.4022128266462342 0.2572595144179789 0.7969784436644882 1.0 1.0 5 Q9UHI6,Q16637 2 +Nuclear inclusion body 0.3637901792759885 0.2507583526551312 0.8020009426938672 1.0 1.0 8 P12270,Q9UNE7 2 +Host cellular component 0.4325414419795973 0.2360561056715644 0.8133891340548502 1.0 1.0 4 P52292 1 +Brca1 c complex 0.5636007827788502 0.2264004801464288 0.8208899545219988 1.0 1.0 3 O60934,P49959 2 +Specific granule 0.2923648687517047 0.2199029218879427 0.8259467606742856 1.0 1.0 38 Q9Y5K8,Q13813,P30519,Q07065,O15121,P50995,P51790 7 +Centriole 0.2975628889016877 0.2164690971784136 0.8286221109813205 1.0 1.0 20 O95684,Q9Y5Y2 2 +Cell division site 0.3010997811025768 0.2098553761221938 0.8337805513360605 1.0 1.0 18 O75935,P35580,Q9H0H5 3 +Tertiary granule 0.2906323214009034 0.2084589243708896 0.8348706516999715 1.0 1.0 39 Q93050,P42785,P10253,Q13813,Q13510 5 +Cohesin complex 0.3803013081783225 0.1936724553469761 0.8464323609037923 1.0 1.0 5 Q8WVM7,Q9UQE7 2 +Proteasome complex 0.2833719785808983 0.1859427890007999 0.8524896265151976 1.0 1.0 47 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Recycling endosome membrane 0.2862324958013816 0.1857317395906608 0.8526551367738151 1.0 1.0 22 Q7Z3C6,P10321,P02786,Q96CV9,Q86Y82 5 +Nuclear stress granule 0.5414220482713457 0.1818995726452477 0.8556615398825262 1.0 1.0 3 P31483,Q08211 2 +Cul4 ring e3 ubiquitin ligase complex 0.3733681462141043 0.1750982660979036 0.8610024206777318 1.0 1.0 5 Q9NV06,Q13620,Q16531,Q92990 4 +Cytoplasmic side of membrane 0.2833287134845564 0.1579492689811386 0.8744967742723921 1.0 1.0 40 P35579,P31689,Q14344,P62942,Q9NR28,P09471,Q9Y5X3,Q12959,Q9UBI6,P29992,A0FGR8,P24666,Q15334,Q9H0H5,O00291,P20339 16 +Autolysosome 0.5330942288881558 0.1423643227584059 0.8867922416195688 1.0 1.0 2 P11279 1 +Secondary lysosome 0.5330942288881558 0.1423643227584059 0.8867922416195688 1.0 1.0 2 P11279 1 +Protein phosphatase type 1 complex 0.531137919791317 0.1393188730381263 0.8891981767903305 1.0 1.0 2 Q9UQ13 1 +Oxidoreductase complex 0.2544428628647093 0.1369448880978852 0.891074357478012 1.0 1.0 62 Q9UDW1,O14949,O43169,P03915,O43674,P22695,Q96CU9,O96000,P21912,O43676,O14874 11 +Euchromatin 0.2720672372666098 0.1359479208802027 0.8918624517242444 1.0 1.0 25 Q9H6U6,P38159,Q8IZL8 3 +Sarcoplasmic reticulum membrane 0.3185135946193617 0.132954899738514 0.8942290485448785 1.0 1.0 10 P16615,P62942 2 +Perinuclear endoplasmic reticulum 0.3558203780429905 0.1316202440508242 0.8952846723961043 1.0 1.0 5 Q9H4L5 1 +Integrin complex 0.5223345288555518 0.1261944256812973 0.8995780237536151 1.0 1.0 2 P05556 1 +Cortical granule 0.5067170662074957 0.1231672014016516 0.9019746972654016 1.0 1.0 3 P35579 1 +H3 histone acetyltransferase complex 0.5092924682099735 0.1084739237708524 0.9136197642593504 1.0 1.0 2 O95251 1 +Sperm connecting piece 0.507988262145407 0.1068132900672752 0.9149371038476256 1.0 1.0 2 P10644 1 +Intrinsic component of postsynaptic specialization membrane 0.4944976609268278 0.1056894277792556 0.9158287687776974 1.0 1.0 3 Q15334 1 +Mpp7 dlg1 lin7 complex 0.4922796247986398 0.1026940940043646 0.9182057611643626 1.0 1.0 3 Q12959 1 +Smn complex 0.3426966723507111 0.1025340928391695 0.9183327532692 1.0 1.0 5 Q9UHI6 1 +Protein complex involved in cell adhesion 0.4902152641878533 0.0999548468592636 0.9203801728353448 1.0 1.0 3 P07948,P05556 2 +Early endosome 0.2605657111802766 0.0855699820746743 0.9318082617432276 1.0 1.0 90 Q5VW38,P41440,Q9P253,Q8IV08,Q15043,Q07954,Q13510,P11717,Q9UIQ6,Q86Y82 10 +Mrna cleavage and polyadenylation specificity factor complex 0.3036886917413249 0.0828763101860605 0.9339498909590468 1.0 1.0 10 Q16630,Q8N684,Q6UN15,Q9UKF6,Q9P2I0 5 +Scf ubiquitin ligase complex 0.3152718280872955 0.0813233366033878 0.935184815528133 1.0 1.0 7 Q96K76 1 +Microtubule associated complex 0.2693209668366165 0.0766022244339628 0.9389399893129124 1.0 1.0 46 P12270,Q9H6D7,Q96GD4,Q9NQS7,Q13561,P49354,Q7Z4H7,P29372,Q86Y91,O15344,Q9NSK0,O95219,Q96P70,O94927,O75935 15 +Protein kinase complex 0.2646776733044955 0.0724373019580101 0.942253900082232 1.0 1.0 22 P12956,P13861,P49736,P06493,Q14004,Q9P287,P11802,Q9Y4W2 8 +Vcp npl4 ufd1 aaa atpase complex 0.3186418543911239 0.0660813146654999 0.9473130870680236 1.0 1.0 6 Q92890,O94888,Q96CS3,Q8TAT6,Q9UNN5 5 +Intrinsic component of presynaptic active zone membrane 0.4602087410306483 0.0652997033614113 0.9479353785253506 1.0 1.0 3 P27824,P20020 2 +Integral component of presynaptic active zone membrane 0.4602087410306483 0.0652997033614113 0.9479353785253506 1.0 1.0 3 P27824,P20020 2 +Microvillus membrane 0.347797716150081 0.064827443606511 0.9483113905661176 1.0 1.0 4 P35222,O00592,P15311 3 +Brush border 0.26353599187374 0.0586075826181844 0.9532646710108904 1.0 1.0 30 P35579,Q14728,P40855,P41440,Q9UEY8,Q96QD8,P60660,P12814 8 +Catenin complex 0.306009144350093 0.0579532969724655 0.9537858295785724 1.0 1.0 7 O60716,P19022,Q9UJX6,P35221,P35222,P25054 6 +Nuclear membrane 0.2707671898530451 0.0566667465685342 0.9548106638267346 1.0 1.0 106 Q9H2V7,Q14728,P20700,P62995,P02545,Q13185,Q8IXM6,Q7Z3B4,P12270,Q9H4L5,P43243,P09525,Q9P035,O75844,Q6NUM9,Q8NFH5,Q03252,Q9BTX1,Q9UH99,O95619,Q6ZRP7,P57740,Q9NXW2,Q8N1F7,Q99523,Q14739,Q9H1E5,O00165,P50402,Q99720,P67809 31 +Sin3 type complex 0.3120066292621289 0.0523358946031161 0.9582610527380572 1.0 1.0 6 Q9UBU8,Q9H0E3 2 +Pole plasm 0.3373572593800948 0.0511107718327557 0.9592372525316796 1.0 1.0 4 Q9Y2W6,O00571,Q9HCE1 3 +Zymogen granule membrane 0.4442270058708306 0.050602629336376 0.9596421676041672 1.0 1.0 3 P49755,O15126 2 +Cdc73 paf1 complex 0.3142950391644972 0.0499144010780986 0.9601906012081148 1.0 1.0 5 Q9GZS3,Q92541,Q8N7H5,Q6PD62 4 +Perinucleolar compartment 0.4422700587084068 0.0489718260009075 0.9609417485849738 1.0 1.0 3 Q92879,Q9H2J4 2 +Golgi stack 0.2551610877499296 0.0455408571318996 0.9636762093824928 1.0 1.0 25 Q99523,Q08379,O95249,Q8TBA6,P04439,O00461 6 +Endoplasmic reticulum protein containing complex 0.2483497865017003 0.0454480168798062 0.9637502085669172 1.0 1.0 60 Q9Y5M8,P13674,Q9UBU6,P62942,P46977,Q8IXB1,Q03519,P04439,Q9H490,Q15006,Q6NUQ1,P04844,Q8TCJ2,P04843,Q9BUN8,O43681 16 +Ap 3 adaptor complex 0.4354762519932287 0.0435849249134469 0.9652352684547992 1.0 1.0 3 Q9P253 1 +Centrosome 0.3000157547787991 0.0398641966952968 0.9682013952985762 1.0 1.0 147 Q9H6D7,Q8TD16,A0AVF1,Q7Z4H7,P16219,Q9UNN8,P55081,P41208,P53985,O95684,O94927,O75935,P50570,Q9Y5K8,P41440,Q9Y5Y2,Q86UY6,Q9UPT5,O75934,Q8TEU7,O43805,Q8N1F7,Q96GD4,Q9UBK9,P50402,P28074,Q5VU43,Q96JB5,Q6DKK2 29 +Ciliary base 0.2953919195840093 0.0334722846291405 0.9732979671048771 1.0 1.0 7 A0AVF1 1 +Endopeptidase complex 0.258050787188905 0.0314351434789501 0.9749225145486596 1.0 1.0 52 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Esc e z complex 0.4070450097847294 0.0253459310943687 0.9797790379694826 1.0 1.0 3 Q92769,Q15022 2 +Cytolytic granule 0.3086460032626457 0.021165415028072 0.9831137029081034 1.0 1.0 4 Q01085,P11279,Q9NVJ2 3 +Blood microparticle 0.2603937907356988 0.0209705820316558 0.983269122651458 1.0 1.0 15 Q08380,P04062 2 +Endoribonuclease complex 0.2756735298205823 0.020646995383684 0.9835272515491402 1.0 1.0 11 Q5KU26,Q15631 2 +Meiotic cohesin complex 0.3073409461663947 0.0200583446851315 0.98399682957944 1.0 1.0 4 Q14683,Q8N3U4,Q9UQE7 3 +Centriolar subdistal appendage 0.3586566677535076 0.0198789286436308 0.984139954330634 1.0 1.0 2 Q14203 1 +Transcription factor tfiih holo complex 0.3904109589040976 0.0175318696565633 0.9860123084405484 1.0 1.0 3 P18074,P19447 2 +Mitotic cohesin complex 0.3071405282034571 0.0160685819230245 0.9871796782717328 1.0 1.0 2 Q9UQE7 1 +Cd95 death inducing signaling complex 0.3002934463645278 0.0158608506260355 0.9873454027454744 1.0 1.0 2 Q9UNN5 1 +Pericentriolar material 0.2888816432996416 0.0156012454858897 0.9875525120502924 1.0 1.0 2 Q15154 1 +Peptidase complex 0.2470276585568659 0.0072178257156076 0.9942410583029327 1.0 1.0 58 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721,Q9Y6J9 8 +Derlin 1 retrotranslocation complex 0.3183300717547291 0.0006131015912006 0.9995108157368242 1.0 1.0 3 Q8TCT9,Q9BUN8 2 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0de989590071072b5926e24ba86673232c858b95 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc 1 complex", "Bloc complex", "Blood microparticle", "Borc complex", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcineurin complex", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Calyx of held", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition fiber", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine head", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystroglycan complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle a", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microfibril", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class i", "Phosphatidylinositol 3 kinase complex class ia", "Phosphatidylinositol 3 kinase complex class iii", "Phospholipid translocating atpase complex", "Phosphorylase kinase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilia coupling link", "Stereocilium bundle", "Stereocilium membrane", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic cleft", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiia complex", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquinone biosynthesis complex", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPTF", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "C12orf43", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C3orf58", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARS2", "CASK", "CAST", "CBFB", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC22", "CCDC47", "CCDC51", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG4", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGA1", "GGA2", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNG12", "GNG5", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSR", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2A1", "GTF2E2", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "IST1", "ITCH", "ITGB1", "ITM2C", "IVD", "JAGN1", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NENF", "NES", "NF1", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5DC3", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANX1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGGT1B", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAMM41", "TAP2", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM41B", "TMEM43", "TMEM65", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPM3", "TPM4", "TPP1", "TPP2", 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sha256:ec0af0eca070ad9504a0647140f268a5ad4fc23ba9e28589db99c75a538070a5 +size 138254 diff --git a/msigdb_gomf/basic/plot_8.png b/msigdb_gomf/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..044090454e2082bb7c2088e649b75e66141d7c22 --- /dev/null +++ b/msigdb_gomf/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:823b4f8d5ca4ca022d839d4aa8fc27f5823a841395ca2f4c4ca6b4d7ceda021b +size 135493 diff --git a/msigdb_gomf/basic/plot_9.png b/msigdb_gomf/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..744ba27bee0db28ca67e8454331812be2ca0e0c1 --- /dev/null +++ b/msigdb_gomf/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0528d87bde2ea3214f7ea3b302070924bf0780ca3dc97d66baa1f4ac97dcd0a3 +size 144576 diff --git a/msigdb_gomf/consensus.joblib b/msigdb_gomf/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..cd06e4ca456959d9ababe1298ecef5892f82ca94 --- /dev/null +++ b/msigdb_gomf/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4163d8ca05ab8b75bfbcfe1b2e3339e40e24da43aca56950ad8b93cb475be1ce +size 157273 diff --git a/msigdb_gomf/df_merge.tsv b/msigdb_gomf/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c1e83f5be73c09e8d69eb6876b4e30822e60271c --- /dev/null +++ b/msigdb_gomf/df_merge.tsv @@ -0,0 +1,49 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Inorganic molecular entity transmembrane transporter activity 29 79 3.2575813224450347 0.0011236605681306 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 0.0009075498420906 0.0054817326666829 0.0004566265384602 0.0002396111162386 1.7343435617995038e-05 +Tetrapyrrole binding 6 16 3.248574732476229 0.0011598473719189 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.0001323589738381 0.0001150461613963 0.0001463124134745 0.0002798752440661 0.0041787730332236 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 12 29 3.147008246669025 0.0016495030947514 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.0480798704909438 0.0094477783308586 0.0113843221380013 0.0068192279567959 0.0017021800757447 +Cation transmembrane transporter activity 23 74 3.14196439274174 0.0016781844336335 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 0.0005969701114864 0.0229384919777869 0.0003150394847307 0.0013112819907734 0.0018712088214595 +Serine hydrolase activity 6 17 2.915555162204264 0.0035505633515824 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 6.761874942359564e-05 0.0213334360876883 0.0010457638608999 0.000131442081142 0.0004226911957548 +Peptide binding 21 72 2.8966917861668646 0.0037712005581209 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 0.0003113838860384 0.1519896688943138 0.0025923350220927 0.0027693353291614 8.484862469567786e-05 +Ion transmembrane transporter activity 35 105 2.871082751215622 0.0040906842333328 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 1.2480237650755514e-05 0.0031507382562496 1.088139934843146e-06 1.670425434121895e-05 6.522938770493734e-06 +Steroid binding 9 22 2.8438162860774736 0.0044576742151272 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 7.612781239454993e-05 0.001549818040453 0.0011305823171555 0.0010432726477128 9.695324700141984e-05 +Iron ion binding 6 20 2.792106754939151 0.0052366076139345 6.524271844660194 22.196601941747577 0.9076096695164306 0.382669917893863 2.4429198675966717 3.289094676807881 0.9378690899634522 0.3126784916965753 0.0605385237015822 0.0333019544595367 0.0196403260480978 0.0150960472167561 0.0273247630743773 +Protein transporter activity 4 14 2.735895489587413 0.0062210780392744 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 2.7007561016292803e-05 0.0002094223372061 8.022003513958758e-05 0.0002704256883961 0.0062087405568419 +Serine type exopeptidase activity 5 7 2.7042915340505163 0.0068450204871801 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 7.74719336836303e-08 0.0007650215967213 8.969776753231084e-07 1.3977780265176686e-08 9.308926617220138e-07 +Monooxygenase activity 5 9 2.6779219612357013 0.0074080476095255 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0006068227655372 0.0002645755687248 0.000109699640749 3.4278668316685995e-05 0.000228605580149 +Transporter activity 58 176 2.6765127011035785 0.0074392746048421 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 7.371257714923652e-11 3.4547551545681746e-06 1.7812641911259462e-09 1.3697002323366223e-10 1.8828481910142503e-10 +Cholesterol binding 7 13 2.668697787100215 0.0076145930702207 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 4.069057408422218e-06 0.0003636173209342 0.0001676359249982 6.474436422857455e-05 6.522583606885229e-05 +Sterol binding 7 16 2.644083985196074 0.0081912329053797 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 1.2411095545713789e-05 0.0006269196579584 0.0003450865767818 0.0001883388130196 0.0002609037219736 +Cargo receptor activity 6 8 2.6235036958995424 0.0087030500822906 3.7063106796116503 7.95873786407767 0.9623237890522576 0.1578680760704802 1.9530058934839476 1.7914972745396005 1.6202205206532496 0.203966946010782 0.0078089954800485 0.0075879492488378 0.0282917804799424 0.0041694420405621 0.0002922281845516 +Abc type transporter activity 4 7 2.6034400945701712 0.0092293395249407 3.0194174757281553 7.652912621359223 0.9831250219385844 0.2361571806590424 1.9482657586917436 2.350049836723345 1.2743804993059251 0.258194993176919 0.0056614489766739 1.0 0.0228657680446322 0.0002704256883961 0.0062087405568419 +Sphingolipid binding 2 6 2.5970534647792167 0.0094027287234794 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 0.002165465243986 7.603990755252932e-05 0.0005957185628407 0.0084670093197957 0.053660443290246 +Organic acid transmembrane transporter activity 8 22 2.511893531735496 0.0120085311975672 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 0.0031916661594833 1.0 0.0037932907097359 0.0231451586112089 0.0052752857705798 +Active transmembrane transporter activity 22 74 2.4906415088642886 0.0127512706548382 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 0.0029471973385719 1.0 0.0119057507164353 0.0011274579552919 0.000780515517568 +Alcohol binding 7 16 2.4699907110900825 0.013511656060009 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 8.546933673396195e-05 0.0016433207319124 0.0012201132329283 0.0011621905058569 0.0025531684631581 +Serine type carboxypeptidase activity 4 5 2.460582262335264 0.0138711768524069 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 2.225138932594199e-07 0.0002150789234385 7.979910524200431e-06 7.539050020943485e-09 2.618746245991888e-07 +Exopeptidase activity 14 32 2.416282061742946 0.0156799096853161 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 2.908848934846708e-05 0.0333019544595367 2.17697919922466e-05 9.44282722724296e-05 2.905428449216434e-05 +Protein transmembrane transporter activity 3 11 2.40094597821379 0.0163527504403095 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 9.226880367419058e-05 6.357667188483331e-05 0.000499833948772 0.0005957243520441 0.0078256896811826 +Antigen binding 4 8 2.3692554922034468 0.017823936002189 2.504854368932039 6.936893203883495 1.1926555941065955 0.2669458193807861 1.6287691845260013 1.3674077446215156 0.9067202373946956 0.2605304200525402 0.2891207521103726 1.0 0.195727907115695 0.1039226879692455 0.0231565450655555 +Phosphatidylcholine binding 2 7 2.3656486706831124 0.0179985152293824 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.001518483453609 5.253086721125362e-05 0.0004144497686355 0.0060189869562698 0.0395358442373242 +Scavenger receptor activity 4 5 2.361792807448968 0.0181868034372787 2.128640776699029 4.245145631067961 0.8895147156183107 0.1752904943890176 1.2029313295363038 0.9324780265795692 1.5451274177295422 0.2106852326062687 0.0006228809854352 0.0013899505248691 0.0054453582128303 0.0025378182642571 0.0001560226497295 +Macromolecule transmembrane transporter activity 3 12 2.3267978606887114 0.0199760263348629 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.000181485244219 0.0001055314719321 0.0008209706516698 0.0011461563975241 0.0022125190482932 +Amyloid beta binding 4 11 2.2962561542097206 0.0216612394913333 3.5898058252427183 10.560679611650484 1.053866189591651 0.2544642672774957 2.009490338022764 1.9342863324228672 1.0942484681219342 0.2534200432416059 0.0168270257414759 0.1604648724397155 0.2957660567507726 0.0579529029875293 0.0317140083874149 +Molecular transducer activity 14 35 2.29079588180735 0.0219752219436957 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.013911777970159 0.3437849543692213 0.7032081264363068 0.0459012264566579 0.1862269168373627 +Threonine type endopeptidase activity 6 8 2.264168306331951 0.0235637650953388 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 0.0089540270958906 1.0 1.0 5.99954180608972e-05 5.383729574080712e-05 +Lipid transporter activity 7 22 2.2573292821520656 0.0239875069516375 6.546116504854369 19.805825242718445 0.7389006587243017 0.301332987440896 3.074370954053146 3.741159812966952 1.4134673193588587 0.2984913911167897 0.0266145727227193 1.0 0.5186527316676074 0.036984008600265 0.0323064863682383 +Inorganic anion transmembrane transporter activity 10 22 2.187979139164033 0.0286711218966944 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.0408464740902213 0.0247821522094747 0.0128121267632092 0.0078371753722585 3.0601500827787595e-05 +Fad binding 4 11 2.1812963240811443 0.0291615061409371 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.0063316996881585 1.0 0.0017973803829616 0.0234536525726143 0.0073870683046854 +Peptide antigen binding 4 6 2.1629626280249044 0.0305440541361088 2.25 5.218446601941747 1.3488418251083294 0.2076946662826 1.4985834735457568 1.269832767279765 0.9581301458127084 0.2397273125927817 0.1994594002405003 1.0 0.1323778037089543 0.048794410492492 0.0048470794580564 +Amide transmembrane transporter activity 2 5 2.1534106807817155 0.0312864169177273 1.9781553398058251 4.745145631067961 1.408683964326367 0.195466717632665 1.3391087077639925 1.811666809674734 1.0002201259794938 0.2223338014085611 0.0343508900176433 1.0 0.172526836456327 0.0114205450108361 0.0698565063333662 +Phosphoric diester hydrolase activity 2 11 2.15214808658665 0.0313856928452243 2.029126213592233 10.385922330097088 0.7290228511785473 0.4081342737861556 1.4528599895098884 1.5700769487624953 0.8628601700755856 0.2801596524830074 0.1621043050744973 0.0221752921749746 0.0775893010395362 0.1120350108259538 0.4261319281434359 +Proton transmembrane transporter activity 7 36 2.114474505968997 0.0344747599751329 12.769417475728156 35.478155339805824 1.2352045534927034 0.2879171268332734 5.319202861157036 2.7149368379617917 1.7021108079122016 0.3308025072902738 0.0007460176661032 0.0050226976439289 0.0006426553910847 0.0018975327944235 0.0028690914750751 +Glycolipid binding 2 8 2.087482552490908 0.0368445365886551 3.95873786407767 9.17233009708738 1.1300394975336625 0.1723818604496332 1.779261971800237 1.789101691327159 1.517965150696512 0.2390589148665743 0.0018241008785546 0.0028214739728005 0.000499833948772 0.007181114657122 0.046330877355434 +Metalloendopeptidase activity 5 14 2.042240029363238 0.0411277275871346 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 0.3872914697039186 0.1444128696349771 0.2685126379615966 0.5509390944914208 0.0202035082798241 +Gtpase inhibitor activity 0 6 2.0386928919198817 0.0414806876169544 1.6868932038834952 5.473300970873787 0.4764128069870422 0.4529434651639549 1.580070988405399 0.6731795131978904 1.0152973781262165 0.3206806250513173 0.1378063248599364 0.0461123069087121 0.0903020002145616 0.2152011075186096 0.3915613744846742 +Atpase coupled transmembrane transporter activity 7 21 2.0237205732681205 0.0429989105393002 8.072815533980583 22.696601941747577 0.8561067713091313 0.3392846662603397 4.166386392056555 3.892074110340729 1.3163009809214623 0.3229730128136945 0.0535543299750337 1.0 0.1033866218184072 0.0025255685357961 0.0065046833684032 +Quaternary ammonium group binding 2 10 2.0183168996460523 0.0435582677772927 2.8567961165048543 12.12864077669903 0.9707568143407772 0.2573327609820879 1.4849985868988949 1.260087490061347 1.304146106648176 0.2795917987269193 0.0039147011366984 0.0001416199496639 0.0010940068356494 0.014896447942982 0.0198699646710478 +Hydrolase activity acting on glycosyl bonds 12 27 1.9922278563445572 0.0463460631528087 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 0.0043376016201349 1.0 0.4999495019072014 0.0078990794284312 0.0007188665281965 +Anion transmembrane transporter activity 15 49 1.9848639356814104 0.0471596117806298 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 0.0106536283463082 0.1184945425124205 0.001182728525427 0.0106901215637622 0.000371491164453 +Carboxypeptidase activity 4 12 1.9829704705975115 0.0473707280789847 3.941747572815534 11.944174757281552 0.6619369631013473 0.2217581052142344 1.5253536449314826 0.7722681563953175 1.6063564059694095 0.2594343390807456 0.0003802243924259 0.0056070915236824 0.0014183751228366 0.0002206103540123 0.0051689545539866 +Metallopeptidase activity 14 40 1.9771498111499557 0.0480246987670816 11.548543689320388 40.60436893203884 1.2053444242445344 0.3510417366391842 4.586289489033314 2.1135899474190585 1.0988837346562612 0.3462572593421246 0.113531940140293 0.3154415256826839 0.0394939574197044 0.1247421146850765 0.000435127860448 +Intramembrane lipid transporter activity 2 7 1.967709583169177 0.0491014625610231 1.385922330097087 3.5849514563106797 0.6981989398710021 0.2957392957485286 1.1208941791969826 1.4021712523598824 1.3078360822178663 0.2625886724506013 0.2456121138851051 1.0 0.16464692140167 0.0746908244780269 0.0615084186624239 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ce125c72db1a7d3497a5f5e41bfabcc140644419 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 1376, + "title": "Average number of proteins per term", + "value": 16.196947674418606 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ddbf1e2769501524018dc8242e2f3ea03097da56 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e0263aa6e5a8e70db4c37b7367f70c91f43f1372 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,385 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Inorganic molecular entity transmembrane transporter activity 0.5203600173543897 3.2575813224450347 0.0011236605681306 0.7871199187884743 0.205233756439913 79 Q9UDW1,Q8TAD4,Q93050,Q15043,P25705,P08133,O15439,P00846,Q8TDW0,P45880,P21796,P51790,Q9Y277,Q9Y487,Q96QD8,Q6N075,Q9Y5K8,O75964,Q9H2J7,P16615,Q13423,Q9HD20,P00403,Q9C0H2,P35670,Q6P4Q7,Q96ES6,Q9UBX3,O43681 29 +Tetrapyrrole binding 0.8004909866288944 3.2485747324762295 0.0011598473719189 0.7974718174897832 0.205233756439913 16 P53701,Q8WUJ1,O43169,P09601,P30519,Q16850 6 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.670340049722586 3.1470082466690252 0.0016495030947514 0.8968519837603199 0.205233756439913 29 Q32P28,P09601,Q15800,P30519,P61457,Q9BU89,Q8NB78,O15121,O15460,Q6UW02,P16435,Q16850 12 +Cation transmembrane transporter activity 0.5047829948579875 3.14196439274174 0.0016781844336335 0.9008500142419172 0.205233756439913 74 Q9UDW1,Q8TAD4,Q93050,Q15043,O43772,P25705,P08133,P00846,P51790,Q9Y487,Q96QD8,Q70HW3,Q9Y5K8,P30825,O75964,Q9H2J7,P16615,Q13423,Q9HD20,P00403,P35670,Q6P4Q7,Q96ES6 23 +Serine hydrolase activity 0.7301785936872074 2.9155551622042637 0.0035505633515824 0.9925106182532308 0.205233756439913 17 Q16740,O14773,P42785,Q9H3G5,P10619,Q9HB40 6 +Peptide binding 0.4804810907767749 2.8966917861668646 0.0037712005581209 0.9944778132232256 0.205233756439913 72 Q8WTV0,O00264,P42892,Q9Y584,P40855,O15212,P55899,Q03519,P10321,Q92973,P55786,Q14978,Q9UIQ6,Q15392,O43813,P52292,O14773,Q9NQX7,Q07954,P04439,Q9UHV9 21 +Ion transmembrane transporter activity 0.5084177858682833 2.871082751215622 0.0040906842333328 0.996448288867118 0.205233756439913 105 Q9UDW1,O43772,Q93050,Q8TAD4,Q15043,P25705,O15439,P08133,P00846,Q8TDW0,P45880,P21796,P51790,Q9Y277,Q9Y487,Q96QD8,P53985,Q6N075,Q70HW3,Q9Y5K8,P41440,P30825,O75964,Q9H2J7,P16615,Q13423,Q9HD20,P00403,Q9C0H2,P35670,Q6P4Q7,Q9BQT8,Q96ES6,Q9UBX3,O43681 35 +Steroid binding 0.66078635039461 2.8438162860774736 0.0044576742151272 0.997861117184928 0.205233756439913 22 Q9H4L5,Q14108,P30536,O15173,O15118,P45880,P21796,P04062,O95772 9 +Iron ion binding 0.6766230317980936 2.792106754939151 0.0052366076139345 0.9992714866281766 0.205233756439913 20 P22830,Q15800,Q9BU89,O15460,Q6UW02,Q16850 6 +Protein transporter activity 0.7273864636230111 2.735895489587413 0.0062210780392744 0.9998134742350028 0.205233756439913 14 O60830,Q9NS69,Q99595,Q9HD20 4 +Serine type exopeptidase activity 0.905155814386061 2.7042915340505163 0.0068450204871801 0.9999213994463644 0.205233756439913 7 Q9HB40,P42785,Q9H3G5,P10619,O14773 5 +Monooxygenase activity 0.8525395244913153 2.6779219612357013 0.0074080476095255 0.9999639793398564 0.205233756439913 9 P09601,P30519,Q9BU89,Q16850,Q6UW02 5 +Transporter activity 0.5419871480278329 2.6765127011035785 0.0074392746048421 0.999965505394379 0.205233756439913 176 Q9H2V7,Q9UDW1,Q99595,O43772,Q93050,Q6NT16,Q8TAD4,Q15043,O15439,Q8WTV0,Q8IXU6,P00846,P39210,P30536,O96000,Q99567,Q9NS69,Q9Y255,Q9Y584,O60830,P45880,P21796,Q8TDW0,P51790,Q9Y277,Q9H4L5,Q9Y487,Q03519,P25705,O43674,Q96QD8,P08183,P53985,P08133,Q6N075,Q70HW3,P51991,Q96GC9,Q7Z3C6,P41440,P30825,O75964,O75027,Q9H2J7,O43676,O15173,Q13423,Q9HD20,P00403,Q9C0H2,P35670,P03915,Q6P4Q7,Q9BQT8,O15118,Q9UBX3,P04062,O43681 58 +Cholesterol binding 0.7409119697284312 2.668697787100215 0.0076145930702207 0.9999729486965984 0.205233756439913 13 Q14108,Q9H4L5,P30536,O15118,P45880,P21796,O95772 7 +Sterol binding 0.6934263673245259 2.644083985196074 0.0081912329053797 0.9999878423550556 0.205233756439913 16 Q14108,Q9H4L5,P30536,O15118,P45880,P21796,O95772 7 +Cargo receptor activity 0.8636808594298264 2.6235036958995424 0.0087030500822906 0.9999940243189972 0.205233756439913 8 Q5KU26,Q07954,Q14108,Q8WTV0,Q08380,O15260 6 +Abc type transporter activity 0.8814683725209025 2.6034400945701712 0.0092293395249407 0.9999971223558848 0.205233756439913 7 O15439,Q03519,P08183,Q9HD20 4 +Sphingolipid binding 0.9279547326236168 2.5970534647792167 0.0094027287234794 0.9999977382364236 0.205233756439913 6 P45880,P21796 2 +Organic acid transmembrane transporter activity 0.6110257752033631 2.511893531735496 0.0120085311975672 0.999999939689121 0.205233756439913 22 P41440,P30825,Q9H2J7,O15439,P08183,Q9BQT8,P53985,Q9UBX3 8 +Active transmembrane transporter activity 0.4465784515177575 2.4906415088642886 0.0127512706548382 0.9999999785721392 0.205233756439913 74 Q9UDW1,Q15043,O15439,O96000,P51790,Q03519,O43674,Q96QD8,P08183,P53985,Q9Y5K8,P41440,O75027,Q9H2J7,O43676,P16615,Q9HD20,P00403,P35670,P03915,Q96ES6,Q9UBX3 22 +Alcohol binding 0.6639812796671843 2.4699907110900825 0.013511656060009 0.9999999925777706 0.205233756439913 16 Q9H4L5,Q14108,P30536,O15118,P45880,P21796,O95772 7 +Serine type carboxypeptidase activity 0.9370104438642364 2.460582262335264 0.0138711768524069 0.9999999955052428 0.205233756439913 5 P10619,P42785,Q9HB40,Q9H3G5 4 +Exopeptidase activity 0.5641456166655653 2.416282061742946 0.0156799096853161 0.999999999640568 0.2224284095566502 32 Q7Z2K6,P09960,O75976,O14773,P42785,P53582,O75844,Q9H3G5,P02786,P55786,Q8IYS1,Q9UIQ6,P10619,Q9HB40 14 +Protein transmembrane transporter activity 0.7360120876552799 2.40094597821379 0.0163527504403095 0.999999999859722 0.2296059653659796 11 O60830,Q9NS69,Q99595 3 +Antigen binding 0.8069587682997575 2.3692554922034468 0.017823936002189 0.9999999999821128 0.2404461840352451 8 P10321,Q03519,Q15392,P55899 4 +Phosphatidylcholine binding 0.8267636166585728 2.3656486706831124 0.0179985152293824 0.999999999985994 0.2404461840352451 7 P45880,P21796 2 +Scavenger receptor activity 0.9122062663185466 2.361792807448968 0.0181868034372787 0.9999999999892424 0.2406253993239956 5 Q5KU26,Q07954,Q8WTV0,Q14108 4 +Ceramide binding 0.9848224599375696 2.356293896882517 0.0184583074456448 0.9999999999926472 0.241891724240069 4 P45880,P21796 2 +Macromolecule transmembrane transporter activity 0.7005898087123418 2.3267978606887114 0.0199760263348629 0.9999999999991256 0.249715127752885 12 O60830,Q9NS69,Q99595 3 +Amyloid beta binding 0.7157368978967796 2.2962561542097206 0.0216612394913333 0.999999999999918 0.2543748962655792 11 Q07954,Q8WTV0,Q9NQX7,Q9UHV9 4 +Molecular transducer activity 0.5423917218737574 2.29079588180735 0.0219752219436957 0.9999999999999474 0.2543748962655792 35 Q5KU26,Q9UNN8,P20645,Q15629,Q14108,Q9Y6I9,Q07954,Q8WTV0,P30536,P11717,O15118,Q99720,O43813,O15031 14 +Threonine type endopeptidase activity 0.7840155666177615 2.264168306331951 0.0235637650953388 0.9999999999999944 0.2593899261694902 8 P28070,P49720,Q99436,P28072,P49721,P28074 6 +Lipid transporter activity 0.574088326747451 2.2573292821520656 0.0239875069516375 0.9999999999999968 0.2598961383106555 22 Q96GC9,Q9H4L5,O15439,P30536,P08183,Q9Y255,O15118 7 +Inorganic anion transmembrane transporter activity 0.5641991941646312 2.1879791391640335 0.0286711218966944 1.0 0.2944139084317276 22 Q15043,O15439,P45880,Q6N075,Q9UBX3,Q8TDW0,P51790,P21796,Q9C0H2,O43681 10 +Fad binding 0.6937531557494515 2.1812963240811443 0.0291615061409371 1.0 0.2972313514809594 11 O95831,Q15392,O15254,Q15067 4 +Peptide antigen binding 0.8240006594820363 2.1629626280249044 0.0305440541361088 1.0 0.3019531780195765 6 P10321,Q03519,Q15392,P55899 4 +Amide transmembrane transporter activity 0.8607906597134111 2.1534106807817155 0.0312864169177273 1.0 0.3019531780195765 5 O15439,P41440 2 +Phosphoric diester hydrolase activity 0.6882244736135775 2.15214808658665 0.0313856928452243 1.0 0.3019531780195765 11 P09601,Q8IV08 2 +Proton transmembrane transporter activity 0.5186067549835593 2.114474505968997 0.0344747599751329 1.0 0.3183709377569323 36 Q9UDW1,Q93050,O75964,Q9Y487,P00846,Q13423,P00403 7 +Glycolipid binding 0.7460656800944154 2.087482552490908 0.0368445365886551 1.0 0.3299177807516532 8 P07602,P50897 2 +Transition metal ion transmembrane transporter activity 0.914845024469816 2.086604085654655 0.0369239376713332 1.0 0.3299177807516532 4 P35670,Q9HD20,Q8TAD4 3 +G protein alpha subunit binding 0.9059333862924752 2.05172124009784 0.040196761325002 1.0 0.3522977298293173 4 P80303,Q02818 2 +Metalloendopeptidase activity 0.6076966890494508 2.042240029363238 0.0411277275871346 1.0 0.3530496690479051 14 O43847,P22695,O75844,Q5JRX3,P42892 5 +Atpase coupled transmembrane transporter activity 0.55036647974874 2.0237205732681205 0.0429989105393002 1.0 0.3610613039852701 21 P35670,Q9Y5K8,O75027,Q03519,O15439,Q9HD20,P08183 7 +Quaternary ammonium group binding 0.688399751986736 2.0183168996460523 0.0435582677772927 1.0 0.3610613039852701 10 P45880,P21796 2 +Hydrolase activity acting on glycosyl bonds 0.5153836478885102 1.9922278563445577 0.0463460631528087 1.0 0.372469267638189 27 Q9NUJ1,P54802,P16278,O75503,P29372,P06865,P10253,P06280,Q9BTY2,O60502,P78549,P04062 12 +Anion transmembrane transporter activity 0.4693665071497788 1.9848639356814104 0.0471596117806298 1.0 0.372469267638189 49 Q9Y277,P41440,Q15043,P30825,O15439,P45880,Q6N075,Q9BQT8,P53985,Q9UBX3,Q8TDW0,P51790,P21796,Q9C0H2,O43681 15 +Carboxypeptidase activity 0.637862979176526 1.9829704705975113 0.0473707280789847 1.0 0.372469267638189 12 P10619,P42785,Q9HB40,Q9H3G5 4 +Metallopeptidase activity 0.4937849450719614 1.9771498111499557 0.0480246987670816 1.0 0.3754658267244561 40 Q7Z2K6,O15372,P09960,O75976,O43847,P22695,O75844,P53582,P02786,Q5JRX3,P55786,P42892,Q9UIQ6,Q10713 14 +Intramembrane lipid transporter activity 0.7385722883071147 1.9677095831691775 0.0491014625610231 1.0 0.3817153247681796 7 Q96GC9,P08183 2 +Primary active transmembrane transporter activity 0.4553667831484811 1.915768656410761 0.0553945489994223 1.0 0.3929015434185829 51 P35670,Q9UDW1,O75027,O15439,Q03519,O43676,O96000,Q9HD20,P08183,P00403 10 +Mhc protein binding 0.6818908396976389 1.8663171824214744 0.0619970022298612 1.0 0.4159422049044906 9 P51572,P25705,Q03519,Q9NUQ9,P68371,Q9BUN8,P07437 7 +Xenobiotic transmembrane transporter activity 0.8585210487808241 1.8641920582615077 0.0622947382401537 1.0 0.4159422049044906 4 P41440,P08183 2 +Calcium ion binding 0.3951709505900183 1.858459321421934 0.0631038149146283 1.0 0.4159422049044906 76 P08133,P67936,O43852,Q8IYU8,Q96A33,O43707,Q02818,Q15293,Q14257,Q9BPX6,P09525,P41208,P80303,P60660,P50995,P20073,Q13813,P16615,Q9NWM8,Q9UBV8,Q9Y680,Q07954,Q8NF37,O43681 24 +Cysteine type endopeptidase inhibitor activity involved in apoptotic process 0.788907920840812 1.8541003014375643 0.0637248116043682 1.0 0.4159422049044906 5 Q15418 1 +Hexosaminidase activity 0.7875462357247199 1.8483446439087732 0.064552501236633 1.0 0.4159422049044906 5 P06865,P54802 2 +Volume sensitive anion channel activity 0.8532288364698375 1.8430649725290256 0.0653195247514561 1.0 0.4161095650833505 4 Q8TDW0,Q9C0H2 2 +Metalloexopeptidase activity 0.532667403471829 1.8404072719862723 0.0657084666415339 1.0 0.416658295385948 20 Q7Z2K6,P09960,O75976,P53582,O75844,P02786,P55786,Q9UIQ6 8 +Structural constituent of postsynapse 0.748153291732015 1.832382157842574 0.0668945043933799 1.0 0.4203051965538393 6 Q12959,P07196,Q16352 3 +Organic cation transmembrane transporter activity 0.7733345322251814 1.7880941237594343 0.073760823512446 1.0 0.4471140667538581 5 O43772 1 +Peptidase activity 0.4153114156239656 1.7808914289520854 0.0749301891007927 1.0 0.4522102640468896 106 Q16740,P09960,P42785,P49720,P02786,Q96RU2,Q8IYS1,P42892,Q9HB40,Q10713,O43847,P22695,O75844,P28072,P55786,Q9UIQ6,Q4J6C6,P28070,O15372,O75976,Q9H3G5,Q7Z2K6,O14773,P53582,Q99436,Q5JRX3,P49721,P28074,Q96K76,P10619 30 +P type transmembrane transporter activity 0.768633993664365 1.7680954247131742 0.0770449522071019 1.0 0.4554616231673539 5 P35670 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.8337991797892705 1.7651850147069597 0.0775326762737997 1.0 0.455727944130855 4 Q16850 1 +Threonine type peptidase activity 0.6613246980948212 1.7634095281800437 0.0778314439467666 1.0 0.455727944130855 9 P28070,Q99436,P28072,P49721 4 +Endopeptidase activity 0.4254666665253734 1.7599666915193666 0.0784134542840828 1.0 0.4559138652604474 55 P28070,Q16740,Q96K76,O43847,P49720,P22695,O75844,P28072,Q5JRX3,Q99436,Q96RU2,P42892,P49721,P28074,O14773,Q4J6C6 16 +Dicarboxylic acid transmembrane transporter activity 0.6936418617472665 1.7581968821942702 0.0787140155605126 1.0 0.4559138652604474 7 P41440,Q9BQT8 2 +Mhc class i protein binding 0.6770808958114611 1.7573557265150574 0.0788571947180134 1.0 0.4559138652604474 8 P51572,P25705,Q03519,P68371,Q9BUN8,P07437 6 +G protein beta gamma subunit complex binding 0.7244409324444413 1.7267692990599013 0.0842091042665993 1.0 0.4672247075437125 6 Q14344,P09471,P41208 3 +Clathrin heavy chain binding 0.7572914960529978 1.7196979363822702 0.0854873631471933 1.0 0.4684847852769917 5 Q5VW38 1 +Phospholipid transporter activity 0.6523314184447867 1.7180897067215706 0.0857802540330592 1.0 0.4684847852769917 9 Q96GC9,P08183,Q9Y255 3 +Porin activity 0.8211602866277437 1.7142706933709595 0.0864790228636307 1.0 0.4684847852769917 4 P45880 1 +Metal ion transmembrane transporter activity 0.4776527266573231 1.6940219628547588 0.0902611096720806 1.0 0.4845947030612357 26 P35670,Q8TAD4,Q15043,P08133,Q9H2J7,Q6P4Q7,P16615,Q96QD8,Q9HD20 9 +Apolipoprotein binding 0.8125955626679425 1.6796614651128752 0.0930232013443876 1.0 0.4926733520268828 4 Q8WTV0 1 +Tap binding 0.806108983121653 1.6533948745845333 0.0982505253074417 1.0 0.4989837326222399 4 P10321,Q03519 2 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9863058363221396 1.6522298061110303 0.0984877124756924 1.0 0.4989837326222399 2 P30519 1 +Phospholipase d activity 0.9863058363221386 1.6522298061110274 0.0984877124756931 1.0 0.4989837326222399 2 Q8IV08 1 +Hydrolase activity hydrolyzing n glycosyl compounds 0.6707293948002704 1.6497261815509776 0.0989989527658949 1.0 0.4989837326222399 7 P29372,O43598,Q16706,P27695,P78549 5 +Symporter activity 0.5739321520846535 1.6196074880557143 0.1053166200538491 1.0 0.5231612606285069 12 Q15043,Q9H2J7,Q96QD8,P53985,Q96ES6 5 +Sodium ion transmembrane transporter activity 0.6316321399175859 1.6130781065925195 0.1067275396802505 1.0 0.52317745110206 9 Q96QD8,Q9H2J7,Q9Y6M7,Q6P4Q7 4 +Phospholipid scramblase activity 0.79575371688752 1.6113692726930295 0.1070992603617186 1.0 0.52317745110206 4 Q96GC9 1 +Amino acid transmembrane transporter activity 0.6093106410324103 1.6051891332824446 0.1084521881881688 1.0 0.5257173292124977 10 Q96QD8,P30825,P08195,Q9H2J7 4 +Ribosomal protein s6 kinase activity 0.973915878708837 1.6032313043097166 0.1088835965673296 1.0 0.5257173292124977 2 Q15418 1 +Gated channel activity 0.5357327916990974 1.5993397438451802 0.1097451331107108 1.0 0.5266742865746469 14 P08133,P51790,P45880,P21796,Q9C0H2 5 +Lysophosphatidic acid binding 0.9709814150635816 1.591618802743053 0.1114703826346272 1.0 0.5289077465698176 2 P50897 1 +Copper ion binding 0.626354194666735 1.5861527574987966 0.1127046615174687 1.0 0.5311014186576608 9 P35670,P00403,O43819,O60888 4 +Active ion transmembrane transporter activity 0.4403184858780934 1.5815214770875274 0.1137588522190571 1.0 0.5342395244144117 44 P35670,Q9Y5K8,Q9UDW1,P41440,Q15043,Q9H2J7,O15439,P16615,Q96QD8,Q9HD20,P00403,Q96ES6,P51790 13 +Mrna methyltransferase activity 0.724011993294746 1.5766285994754097 0.1148810081215692 1.0 0.5343138571514375 5 Q96FX7 1 +Phosphatidylserine binding 0.6034378823546476 1.5738885710218895 0.1155132126036471 1.0 0.5343138571514375 10 Q8WTV0 1 +Lipoprotein particle receptor activity 0.96609064232149 1.5722593275422745 0.1158904214671427 1.0 0.5343138571514375 2 Q8WTV0 1 +Structural constituent of cytoskeleton 0.4557717370934641 1.5658260390933898 0.1173893484804213 1.0 0.5343138571514375 34 O95619,Q16204,Q9BVA1,P07196,Q13813,P08670,Q16352,P07197,O00291,P68371 10 +Hydrolase activity hydrolyzing o glycosyl compounds 0.4934236951724361 1.564680788830059 0.1176577752302947 1.0 0.5343138571514375 20 Q9NUJ1,P54802,P16278,P06865,P10253,P06280,P04066,Q9BTY2,O60502,P04062 10 +Cyclic nucleotide binding 0.7176313775510788 1.549031920728979 0.1213740468349173 1.0 0.5386148023816782 5 P41440 1 +Anion channel activity 0.5436711588431746 1.5399903952148288 0.1235626946560595 1.0 0.5397532312594854 13 P45880,Q8TDW0,P51790,P21796,Q9C0H2 5 +Abc type xenobiotic transporter activity 0.9546788392566056 1.5270671245247922 0.126744320826778 1.0 0.5493689817388907 2 P08183 1 +Efflux transmembrane transporter activity 0.9546788392566056 1.5270671245247922 0.126744320826778 1.0 0.5493689817388907 2 P08183 1 +Hormone binding 0.6273184931067199 1.5126589701656734 0.1303663066962674 1.0 0.5499534619944427 8 P30536,P42892 2 +Modified amino acid binding 0.4630142941001824 1.5107650787579006 0.1308483149097041 1.0 0.5499534619944427 23 P41440,P08133,Q14108,Q8WTV0,P00374,O43813 6 +Guanylate kinase activity 0.7036553524804334 1.4884201168159743 0.1366401346097883 1.0 0.5641576870896642 5 Q14168,Q12959,Q00013,O14936 4 +Atpase binding 0.4511411484926943 1.4860175734265928 0.1372744727731547 1.0 0.5641576870896642 27 Q93050,Q16740,Q9Y487 3 +Peptide transmembrane transporter activity 0.9442451907401366 1.4857342144304762 0.1373494369004633 1.0 0.5641576870896642 2 O15439 1 +5 3 exodeoxyribonuclease activity 0.9422888816433046 1.4779838014801006 0.13941211400968 1.0 0.5667633278377178 2 Q8IV08 1 +Peptidyl proline dioxygenase activity 0.7624751897513831 1.4756299360682783 0.1400432641459477 1.0 0.5667633278377178 4 O15460,Q32P28 2 +Procollagen proline dioxygenase activity 0.7624751897513831 1.4756299360682783 0.1400432641459477 1.0 0.5667633278377178 4 O15460,Q32P28 2 +Phospholipid binding 0.3703946058731919 1.4633032806823187 0.1433844104492625 1.0 0.5735376417970501 84 P07602,Q9H6U6,Q14108,O00291,P08133,P09525,Q8WTV0,P50897,Q8NCC3,Q8TEU7,Q8NFH5,O14773,P45880,P21796,P20073 15 +Protein disulfide isomerase activity 0.5988612972062777 1.445010051682583 0.1484550622738252 1.0 0.5881830806243382 9 Q96JJ7 1 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.7539967373572427 1.4409085440382496 0.1496105219611325 1.0 0.5881830806243382 4 P46977,Q8TCJ2,P04843 3 +Oligosaccharyl transferase activity 0.7539967373572427 1.4409085440382496 0.1496105219611325 1.0 0.5881830806243382 4 P46977,Q8TCJ2,P04843 3 +Oxidoreductase activity acting on the ch ch group of donors 0.44193033387448 1.4270129747925262 0.1535761547866241 1.0 0.5889228726864711 31 Q9H7Z7,Q15392,Q15067,O15254,Q8N8N7,P21912,P36551,Q6NUM9,P16219,Q8N4Q0,P50336 11 +Organic anion transmembrane transporter activity 0.4410681128775527 1.4260283998630714 0.1538601445115877 1.0 0.5889228726864711 32 Q14728,P41440,Q8TB61,Q99808,P30825,O15439,Q96QD8,Q9BQT8,P53985,Q9Y6M7,Q9UBX3 11 +Passive transmembrane transporter activity 0.4367654589411013 1.4240685502380468 0.1544266293188765 1.0 0.5889228726864711 36 P25705,P08133,O75964,P39210,P45880,P00846,Q8TDW0,P51790,P21796,Q9C0H2 10 +L amino acid transmembrane transporter activity 0.609391504310366 1.423384444666255 0.154624739302247 1.0 0.5889228726864711 8 Q96QD8,P30825,P08195 3 +Translation repressor activity mrna regulatory element binding 0.6571965744173414 1.422315603700719 0.1549346510992024 1.0 0.5889228726864711 6 Q00577,P00374,Q9BPZ3 3 +L ascorbic acid binding 0.6559941705137533 1.416816500534899 0.1565365841495658 1.0 0.5917426917302269 6 O15460,Q32P28 2 +Sulfur compound transmembrane transporter activity 0.6072946733196698 1.4129099377749443 0.1576822067187619 1.0 0.5932728763975809 8 O15439,Q70HW3 2 +Palmitoyl protein hydrolase activity 0.6528912297752245 1.4026184055302882 0.1607306603125176 1.0 0.6009929037772398 6 P50897,Q9UMR5 2 +Chromo shadow domain binding 0.741711321730165 1.390520895681591 0.1643707585953906 1.0 0.6079950640517675 4 P46100 1 +Pattern recognition receptor activity 0.9168568633844234 1.3772661276335847 0.1684299835647746 1.0 0.6180257530270132 2 Q8WTV0 1 +Low density lipoprotein particle binding 0.9168568633844234 1.3772661276335847 0.1684299835647746 1.0 0.6180257530270132 2 Q8WTV0 1 +Manganese ion transmembrane transporter activity 0.914248451255305 1.3669447342270171 0.1716426288670844 1.0 0.6203530081677334 2 Q9HD20 1 +Zinc ion transmembrane transporter activity 0.9142484512553032 1.3669447342270102 0.1716426288670867 1.0 0.6203530081677334 2 Q8TAD4 1 +Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor 0.7347021144742328 1.3617406286885083 0.1732797544061113 1.0 0.6203530081677334 4 Q9UHG3 1 +Dopamine receptor binding 0.6733968697294155 1.3565472212809897 0.1749251214891574 1.0 0.6203530081677334 5 P50570,Q15334,Q14344 3 +Acylglycerol o acyltransferase activity 0.6084902871534704 1.3504312171702906 0.1768777030431694 1.0 0.6256650883994888 7 Q96N66,Q8NCC3 2 +Sphingosine n acyltransferase activity 0.9087055754809312 1.3450205531257826 0.178618597334339 1.0 0.6285912785985946 2 Q96G23 1 +Dna n glycosylase activity 0.6676415462854972 1.331386715721235 0.1830617982138211 1.0 0.6386828855840444 5 P78549,P29372,P27695 3 +Ephrin receptor binding 0.6365142596673624 1.3275314961344815 0.18433292829486 1.0 0.6405103771053722 6 Q15375,P98172,P46108,P62993 4 +Cyclin binding 0.5076135782954079 1.320562783706087 0.1866471888781562 1.0 0.64253164508003 13 O14976,Q9BWF3,Q14004,P12956,O14777,Q96JB5 6 +Pdz domain binding 0.522658223083285 1.3203558619770206 0.1867162327991578 1.0 0.64253164508003 12 Q9UBI6,Q15067,Q9UQB8 3 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.4913595025155849 1.3183528056110794 0.1873855715715275 1.0 0.64253164508003 14 Q9H7Z7,Q14739,Q8N8N7,Q15392,Q8N4Q0 5 +Monocarboxylic acid transmembrane transporter activity 0.6317053039205526 1.3054414814031277 0.1917425612148067 1.0 0.6482500349670123 6 P53985 1 +Hexosyltransferase activity 0.4260627268106009 1.295043628361687 0.1953051795225384 1.0 0.654704445406609 31 Q2TAA5,Q13126,P04062,P46977,Q9BT22,P06865,Q86SF2,O43505,P07686,Q8NAT1,Q10472,Q8TCJ2,P04843,P13807 14 +Beta n acetylhexosaminidase activity 0.7182860060526237 1.294273313552495 0.1955710309635323 1.0 0.654704445406609 4 P06865 1 +Secondary active transmembrane transporter activity 0.4263907957388102 1.2872261547332922 0.1980154735567132 1.0 0.6564289786720816 24 P41440,Q15043,Q9H2J7,Q96QD8,P53985,Q96ES6,P51790,Q9UBX3 8 +Heme transmembrane transporter activity 0.8904466905771111 1.2729129488887965 0.2030489337875645 1.0 0.6620742485585042 2 O75027 1 +Histone h3 methyl lysine 4 demethylase activity 0.6530678851174876 1.2676028774700856 0.204939803843533 1.0 0.6666599765690343 5 Q8IUF8,Q8NB78,Q9H6W3,P29375 4 +Cysteine type endopeptidase regulator activity involved in apoptotic process 0.5899359753197831 1.2602293381000205 0.2075866422357906 1.0 0.6674006556172423 7 Q15418 1 +Demethylase activity 0.5451905116217686 1.2599013240032162 0.2077049610641741 1.0 0.6674006556172423 10 Q16850 1 +Sterol transporter activity 0.5896912560064443 1.2590377371328227 0.2080167016578773 1.0 0.6674006556172423 7 P30536,O15118 2 +Mannose binding 0.6215054792031721 1.2585408048954911 0.2081962396987537 1.0 0.6674006556172423 6 O75503 1 +Modified amino acid transmembrane transporter activity 0.8868842232892908 1.257527452034402 0.2085627048803882 1.0 0.6674006556172423 3 P41440 1 +Lipopolysaccharide binding 0.6175008381085656 1.2401126436255927 0.2149337330472314 1.0 0.6783229740206201 6 Q8WTV0 1 +Cytoskeletal anchor activity 0.6112968790351332 1.211552819481484 0.2256836041779313 1.0 0.6978441333681651 6 Q9UQB8 1 +Membrane insertase activity 0.56474209785367 1.1992406029873846 0.2304344034567185 1.0 0.7054265443691746 8 P62072 1 +Lipid binding 0.3874928259416349 1.1978928701963345 0.2309587257794674 1.0 0.7054265443691746 131 P08133,Q8WTV0,P30536,P11717,A6NIH7,P45880,P21796,P07602,Q9H6U6,Q14108,Q9H4L5,P09525,Q15067,P50897,Q8NFH5,P20073,P28070,O94788,O15254,P56589,O15173,Q8TEU7,O14773,O95772,Q8NCC3,O15118,O00291,P04062 28 +Structural constituent of nuclear pore 0.434408498168316 1.1859572285918956 0.2356391909448896 1.0 0.7054265443691746 21 P12270,Q8N1F7,Q99567,P57740,Q8NFH5,Q7Z3B4,Q9BTX1 7 +Acetylglucosaminyltransferase activity 0.6322178159011056 1.176263244314115 0.2394896986625068 1.0 0.7054265443691746 5 P06865,Q8NAT1,O43505 3 +Atpase coupled cation transmembrane transporter activity 0.4690135919459279 1.1754767005123623 0.2398040533650041 1.0 0.7054265443691746 14 P35670,Q9Y5K8,Q9HD20 3 +Structural constituent of synapse 0.5594043370753651 1.172338738465121 0.2410610844957352 1.0 0.7054265443691746 8 Q12959,P07196,Q16352 3 +Acid amino acid ligase activity 0.6298255302451716 1.165783921747637 0.2437018194314819 1.0 0.7054265443691746 5 P22234 1 +Oxidoreductase activity acting on a heme group of donors 0.6002074962752718 1.160485421399108 0.2458512259270171 1.0 0.7054265443691746 6 P00403 1 +Protein carrier chaperone 0.5078889050646955 1.1552983241278774 0.247968282008667 1.0 0.7054265443691746 11 Q15070,P62072 2 +Retromer complex binding 0.626977595832917 1.1533103320437488 0.2487830308263356 1.0 0.7054265443691746 5 P20645,P11717 2 +Acid phosphatase activity 0.8580966654904799 1.1520981728551842 0.2492807338804876 1.0 0.7054265443691746 3 Q9NPH0 1 +Wide pore channel activity 0.6261372307122963 1.14963006661265 0.2502962690882557 1.0 0.7054265443691746 5 P45880 1 +Amino acid cation symporter activity 0.8588196935115723 1.1486677499810087 0.2506930088637547 1.0 0.7054265443691746 2 Q9H2J7 1 +Organic acid sodium symporter activity 0.8588196935115723 1.1486677499810087 0.2506930088637547 1.0 0.7054265443691746 2 Q9H2J7 1 +Amino acid sodium symporter activity 0.8588196935115723 1.1486677499810087 0.2506930088637547 1.0 0.7054265443691746 2 Q9H2J7 1 +5 3 exonuclease activity 0.5386768080657294 1.132263069261163 0.2575238515572113 1.0 0.7141286803258691 9 Q9UQ84,Q9BQ61,Q8IV08 3 +Prenyltransferase activity 0.5621286072730843 1.124656006075456 0.2607348310378978 1.0 0.7189802154471893 7 P49354 1 +Voltage gated anion channel activity 0.5603093651087732 1.1157816360314396 0.2645156163104465 1.0 0.7198983056012056 7 P51790,P45880,P21796 3 +Udp glycosyltransferase activity 0.4552865267799938 1.1126936473323985 0.2658400248238171 1.0 0.7198983056012056 15 P06865,Q86SF2,O43505,P07686,Q8NAT1,P13807 6 +Isocitrate dehydrogenase activity 0.6737357259379907 1.1112456174483647 0.2664626406313375 1.0 0.7198983056012056 4 P50213,P48735,O75874 3 +Organic hydroxy compound transmembrane transporter activity 0.8467921444282644 1.1108709358558295 0.2666239074061947 1.0 0.7198983056012056 3 P53985 1 +Dna apurinic or apyrimidinic site endonuclease activity 0.6698205546492502 1.0952047100188662 0.2734269626945562 1.0 0.7251050320556844 4 P23396,P78549,P27695 3 +Metalloaminopeptidase activity 0.4840369184610717 1.0923382599953897 0.2746844493643756 1.0 0.7254621925631111 12 Q9UIQ6,P09960,P55786 3 +Solute cation symporter activity 0.5136557858833037 1.0882784557987213 0.2764721985034435 1.0 0.7265798660737925 10 Q15043,Q96ES6,Q96QD8,Q9H2J7 4 +Cysteine type endopeptidase inhibitor activity 0.4959929596736153 1.0875068708964133 0.2768128636917684 1.0 0.7265798660737925 11 Q15418 1 +Nuclear localization sequence binding 0.4513698859435899 1.0871480114250658 0.2769714024402447 1.0 0.7265798660737925 15 Q8TEX9,P52292,Q9BVL2,Q92973,O60684,Q14978 6 +Hsp70 protein binding 0.4510507188507288 1.0850665497932124 0.2778921812099832 1.0 0.7265798660737925 15 P31689,Q8IXB1,P06493,P46379,P02786,Q9NXW2,O60884 7 +Galactosidase activity 0.8402347570916348 1.0762496070565857 0.2818156393015385 1.0 0.7265798660737925 2 P16278 1 +Galactoside binding 0.8402347570916348 1.0762496070565857 0.2818156393015385 1.0 0.7265798660737925 2 P16278 1 +Cyclin dependent protein kinase activity 0.5816164996270312 1.0749074808292816 0.2824161523852044 1.0 0.7265798660737925 6 Q14004,P06493,P11802,P21127 4 +Solute sodium symporter activity 0.6090496771406728 1.0748669285232555 0.2824343103635724 1.0 0.7265798660737925 5 Q96QD8,Q9H2J7 2 +Isoprenoid binding 0.8367809904443204 1.074471855986099 0.2826112521668471 1.0 0.7265798660737925 3 O94788 1 +Beta 2 microglobulin binding 0.839256602543199 1.0724537952892843 0.283516256500594 1.0 0.7265798660737925 2 P55899 1 +Scaffold protein binding 0.430441705098201 1.0724375099861856 0.283523567659945 1.0 0.7265798660737925 19 P07602,Q9UQB8 2 +Single stranded dna exodeoxyribonuclease activity 0.6080027412970931 1.0702922080551112 0.2844878006217071 1.0 0.7265798660737925 5 Q8IV08 1 +Exodeoxyribonuclease activity 0.5100936091941052 1.0688824027916242 0.2851226622202918 1.0 0.7265798660737925 10 Q9UQ84,Q8IV08 2 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 0.6075523537142204 1.068324451894829 0.2853741823353433 1.0 0.7265798660737925 5 P36551,O15254,Q15067 3 +Sh3 domain binding 0.4349036836734686 1.067457391193057 0.2857653444656294 1.0 0.7265798660737925 18 P50570,Q14185,Q16204,Q8N8S7,Q96PU8,P46108,O43813,O75525,Q07666 9 +Structural constituent of muscle 0.5791107552414823 1.0633845216550604 0.287607609167039 1.0 0.7265798660737925 6 P60660,P67936 2 +Voltage gated channel activity 0.508636354755341 1.0609490024039838 0.2887130780157494 1.0 0.7265798660737925 10 P51790,P45880,P21796 3 +Hydrolase activity acting on ether bonds 0.5487710309120416 1.0595164184148362 0.2893646559654348 1.0 0.7265798660737925 7 O43865,P07099,P09960 3 +Calcium dependent phospholipid binding 0.5067513304102201 1.0506883016088795 0.2934017706088458 1.0 0.7320563843267711 10 P08133,P09525,P20073 3 +Purine nucleotide transmembrane transporter activity 0.4892699496289687 1.0492064035834172 0.2940831320594887 1.0 0.7320563843267711 11 O15439,P41440,Q8TB61 3 +O methyltransferase activity 0.5456332674361817 1.0442257872839706 0.2963809388352829 1.0 0.7337910239587523 7 P21964 1 +G protein coupled receptor activity 0.8232316471116442 1.0254092169130784 0.3051701410357472 1.0 0.743732893520442 3 Q99720 1 +Protease binding 0.3919031180334499 1.0098861899364286 0.3125498198277028 1.0 0.7518843946279391 25 P46379,P14174,P41440,P07602 4 +Flavin adenine dinucleotide binding 0.392187838230862 1.0098720517758075 0.3125565942784747 1.0 0.7518843946279391 30 O95831,Q15392,Q15067,O15254,A1L0T0,Q8NB78,P16219,P16435 8 +Structural constituent of eye lens 0.8134449768706411 0.990140262302712 0.3221055662748453 1.0 0.7620859398954731 3 P08670 1 +Exoribonuclease activity 0.3889906239870243 0.989669334926577 0.3223357681825329 1.0 0.7620859398954731 24 Q9UIV1,Q13868,Q5RKV6,Q9Y3B8,Q9NQT5 5 +Intramolecular oxidoreductase activity transposing c c bonds 0.5871391336141983 0.979357489907711 0.3274033736815847 1.0 0.7684781078219767 5 Q13011 1 +Snap receptor activity 0.4345039252667596 0.977285346952928 0.3284279053060768 1.0 0.7685659824849689 15 O95249,Q86Y82,Q9P2W9 3 +Neurotransmitter transmembrane transporter activity 0.8099119660906402 0.959487740114594 0.3373130929281345 1.0 0.776158554965072 2 Q9H2J7 1 +Proton transporting atp synthase activity rotational mechanism 0.47116188499558 0.946241856722608 0.3440252416674727 1.0 0.7812180260441857 11 O75964,P00846 2 +Proton channel activity 0.47116188499558 0.946241856722608 0.3440252416674727 1.0 0.7812180260441857 11 O75964,P00846 2 +Aldehyde dehydrogenase nad p plus activity 0.5215505899283777 0.9271814125546984 0.3538323518380009 1.0 0.7852795421436922 7 O94788 1 +Neutral amino acid transmembrane transporter activity 0.573074748116402 0.9184053451566532 0.358406693382518 1.0 0.792873971212773 5 Q96QD8,P08195 2 +Oxidoreduction driven active transmembrane transporter activity 0.380684661764183 0.914724790834372 0.3603361263626121 1.0 0.7958627766853199 30 O43676,O96000,Q9UDW1,P00403 4 +Folic acid binding 0.6215794172096745 0.8991325586645775 0.3685820575668437 1.0 0.8060552139200666 4 P41440 1 +Peptide alpha n acetyltransferase activity 0.6214664594365031 0.8986782956676937 0.3688240410520356 1.0 0.8060552139200666 4 Q86UY6 1 +Solute cation antiporter activity 0.7837693266431645 0.8842903645413507 0.3765394883390749 1.0 0.8168321380343146 3 P51790 1 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.5395033977795389 0.8821875304137988 0.3776754040359842 1.0 0.8171090502413747 6 O60885,P06493,Q14004 3 +Clathrin binding 0.3924739858143414 0.8766799592460328 0.3806604950199577 1.0 0.8197008468661374 21 Q07954,O00291,Q5VW38 3 +Sulfuric ester hydrolase activity 0.785458102380172 0.867027314806169 0.3859270436913413 1.0 0.823919418262687 2 O43681 1 +Organophosphate ester transmembrane transporter activity 0.4428933158494789 0.8501322628517741 0.395251556231345 1.0 0.8315996045479063 12 P41440 1 +Nucleotide transmembrane transporter activity 0.4428933158494789 0.8501322628517741 0.395251556231345 1.0 0.8315996045479063 12 P41440 1 +Nucleobase containing compound transmembrane transporter activity 0.4172111599561527 0.8448182041622294 0.3982123490354385 1.0 0.8327358545178776 14 P51991,O15439,P41440,Q8TB61 4 +Epoxide hydrolase activity 0.5540273174428987 0.836520545936781 0.4028621231477158 1.0 0.8386358267038684 5 P07099,P09960 2 +Ether hydrolase activity 0.5540273174428987 0.836520545936781 0.4028621231477158 1.0 0.8386358267038684 5 P07099,P09960 2 +Growth factor binding 0.4403065009416298 0.8350329575407907 0.4036991522098854 1.0 0.8391088118441122 12 Q99523,O43847,O00165,P11717,P27695,Q92896,Q99584 7 +Mhc class ib protein binding 0.776002608412148 0.8317889529245744 0.405528080501917 1.0 0.840109587680159 2 Q03519 1 +Nucleoside diphosphate kinase activity 0.5504120046582688 0.8210860452294154 0.4115972581397105 1.0 0.845310189851107 5 P22392 1 +Nadh dehydrogenase activity 0.3784410292548074 0.8134445555259807 0.4159632226320826 1.0 0.8501742272880373 22 O43676,O96000,O95831 3 +Mrna 3 utr binding 0.3513439164870842 0.8103437734813616 0.4177426236408972 1.0 0.8501742272880373 48 P51114,Q92945,O75150,Q9BWF3,P35637,Q92804,Q14103,Q5VTR2,Q14671,Q13151,Q14011,Q71RC2,Q9Y6M1,P22626 14 +Trna methyltransferase activity 0.4864833399025081 0.8064650699145538 0.4199747408165373 1.0 0.8510828326414659 8 Q96FX7 1 +Protein lipid complex binding 0.7604904190453909 0.8027293610358006 0.4221311786233601 1.0 0.8525863727610751 3 Q8WTV0 1 +Vitamin transmembrane transporter activity 0.5200001863271791 0.794109672243491 0.4271315872969656 1.0 0.8567537377851673 6 P41440 1 +Calcium channel regulator activity 0.5179571729292632 0.7849487617029315 0.4324836108083749 1.0 0.8649672216167499 6 P05771,Q13586,P62942 3 +Toxic substance binding 0.7626344962504061 0.7825399590573641 0.4338973113151425 1.0 0.8665351239036809 2 P34913 1 +Aminopeptidase activity 0.4038378743124794 0.7793079047829842 0.4357983593229193 1.0 0.8669605910124564 15 P55786 1 +Phosphatidylinositol bisphosphate phosphatase activity 0.7616563417019857 0.7789646650166067 0.4360005297824272 1.0 0.8669605910124564 2 Q10713 1 +Lipid transfer activity 0.5386897350075353 0.7713266997851408 0.4405133103591254 1.0 0.8708998779513745 5 P30536 1 +2 acylglycerol 3 phosphate o acyltransferase activity 0.7490728395862146 0.7633171221949356 0.4452742931470825 1.0 0.8740334199292235 3 Q96N66 1 +Lysophospholipid acyltransferase activity 0.5125883711106348 0.7609441307463904 0.4466904381268994 1.0 0.8752047457733115 6 Q96N66,Q8NF37 2 +Single stranded dna helicase activity 0.4157173894797382 0.7586975496400863 0.4480335030472284 1.0 0.8752047457733115 13 P33991 1 +L glutamine transmembrane transporter activity 0.7554613628953333 0.7564165151469842 0.4493995092355949 1.0 0.8752047457733115 2 Q96QD8 1 +Leucine zipper domain binding 0.745596868884528 0.7514056791218002 0.4524085459439113 1.0 0.8753583600832859 3 Q6P1K2,Q96IZ0 2 +Lrr domain binding 0.745596868884528 0.7514056791218002 0.4524085459439113 1.0 0.8753583600832859 3 Q6P1K2,Q96IZ0 2 +Neurotrophin binding 0.7538311053146345 0.7505109050961817 0.4529470584151887 1.0 0.8753583600832859 2 Q99523 1 +Lamin binding 0.4737986232297714 0.7439315110811967 0.4569179106085439 1.0 0.8797266447326593 8 Q9UH99,Q9ULX6 2 +Double stranded telomeric dna binding 0.5004419030232905 0.7070476222931891 0.4795368838851923 1.0 0.8957394146405303 6 P12956,Q00577 2 +Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor 0.7401369416367736 0.7013964691263852 0.4830556248896194 1.0 0.8982223511461032 2 Q8IXB1 1 +Peptidyl proline 4 dioxygenase activity 0.7272931959493549 0.6894264643900525 0.4905549342094395 1.0 0.9031775049960824 3 O15460 1 +Procollagen proline 4 dioxygenase activity 0.7272931959493549 0.6894264643900525 0.4905549342094395 1.0 0.9031775049960824 3 O15460 1 +Intramolecular oxidoreductase activity 0.3710288931977951 0.687571585967237 0.4917226064998603 1.0 0.9031775049960824 20 P14174,Q13011,Q96JJ7 3 +Phosphatidic acid binding 0.5677005756391488 0.6868395135145686 0.492183866737204 1.0 0.9031775049960824 4 O60313,Q8TEU7 2 +Ww domain binding 0.5674727795958145 0.6859654884836346 0.492734871497555 1.0 0.9031775049960824 4 P50570,Q8N8S7 2 +Protein geranylgeranyltransferase activity 0.5648128073213954 0.675777691540931 0.4991818004912189 1.0 0.9072558287415052 4 P49354 1 +Poly a binding 0.4106251307889275 0.6639785030771017 0.5067040698718648 1.0 0.9085269473034762 12 O14979,Q71RC2 2 +Gtpase activating protein binding 0.5101716881001911 0.6525452748378567 0.5140494758229708 1.0 0.9085269473034762 5 Q14C86 1 +Exonuclease activity 0.3469676851395952 0.6520949417583621 0.5143399269620716 1.0 0.9085269473034762 37 Q9UIV1,Q9BQ61,Q13868,Q5RKV6,Q8IV08,Q9Y3B8,Q9UQ84,Q9NQT5 8 +Syntaxin binding 0.3774145119255572 0.6510866707304384 0.5149905403703923 1.0 0.9085269473034762 17 O95721,O75150,Q9P253,Q08379,Q8N1B4,Q9BVK6,Q99747,O15400 8 +Protein prenyltransferase activity 0.5089858413882701 0.6476900994037968 0.5171854090584116 1.0 0.9085269473034762 5 P49354 1 +O acyltransferase activity 0.4068702592521748 0.6427151137911871 0.5204089722283771 1.0 0.9085269473034762 12 P23786,Q8NCC3,Q96N66,P35610,Q9NUQ2,Q8NF37 6 +Immunoglobulin binding 0.7225301597652612 0.639669954328702 0.5223871928315602 1.0 0.9085269473034762 2 P55899 1 +C acetyltransferase activity 0.4590972904852964 0.6303958019610392 0.5284356567742687 1.0 0.9085269473034762 7 Q9BWD1 1 +Lipase inhibitor activity 0.5502940964824474 0.620799939942185 0.534731262776015 1.0 0.9085269473034762 4 P09525 1 +Phosphatidylinositol 3 kinase regulator activity 0.7169872839908743 0.6206026057796374 0.5348611247515276 1.0 0.9085269473034762 2 O00459 1 +O acetyltransferase activity 0.716335180958587 0.6183716037358693 0.5363304117008232 1.0 0.9085269473034762 2 Q8NF37 1 +Tropomyosin binding 0.7049396761029043 0.6156624249671565 0.5381173416078002 1.0 0.9085269473034762 3 Q9NYL9 1 +Phosphatidylinositol phosphate phosphatase activity 0.7041748206131678 0.6131804784764916 0.5397570112026857 1.0 0.9101784894790386 3 Q13614,Q10713 2 +Misfolded protein binding 0.4075402103809152 0.5925766714561653 0.5534644952655092 1.0 0.9261277909292254 11 P46379,P48723,Q13217 3 +Sulfatide binding 0.6963109198445154 0.5878367945594136 0.5566418442858441 1.0 0.92660325153468 3 P50897 1 +Beta tubulin binding 0.3602726188688864 0.5857241666695682 0.5580608912257423 1.0 0.92660325153468 19 Q9H6U6,O75381,Q9UBK9,P50402,Q9H0H5 5 +Adrenergic receptor binding 0.6940639269406369 0.5806552899636812 0.5614728005281295 1.0 0.92660325153468 3 Q15334,Q07021 2 +Phosphatidylinositol monophosphate phosphatase activity 0.7039452233452872 0.5764943778327273 0.5642810689143418 1.0 0.92660325153468 2 Q13614 1 +N acyltransferase activity 0.3629935525206789 0.5584434477331579 0.5765416113248119 1.0 0.9366248609007568 17 Q969G3,Q96G23,Q86UY6,Q96QD8,P27544 5 +Deoxyribonuclease activity 0.3585962969199596 0.551045928611363 0.5816021904307922 1.0 0.9398165924828316 18 Q9UQ84,Q8IV08 2 +Mrna 3 utr au rich region binding 0.399575221734097 0.5500386503860145 0.5822928640337108 1.0 0.9398165924828316 11 Q92945,Q14103,Q9H2U1,Q01085,Q13151,Q15717 6 +Pre mrna intronic binding 0.4835746439114817 0.5456699885293137 0.5852928051605184 1.0 0.9398165924828316 5 P22626 1 +Spectrin binding 0.4619756013772476 0.5413744042384482 0.5882495457299282 1.0 0.9398165924828316 6 P35611 1 +2 oxoglutarate dependent dioxygenase activity 0.3616058832039675 0.5163934919125881 0.6055796103024447 1.0 0.9423317164155672 15 O75151,Q32P28,P13674,Q8IUF8,P29375,O15460,Q9H6W3 7 +Amide binding 0.3107541306512156 0.5043710395129872 0.6140006651565408 1.0 0.9423317164155672 105 Q8WTV0,P42892,Q9Y584,P45880,P21796,P07602,P40855,O15212,P55899,Q03519,P10321,Q92973,P55786,Q14978,Q9UIQ6,Q15392,O43813,P41440,P52292,O14773,Q9Y680,Q9NQX7,P62942,Q07954,Q9UHV9 25 +Class i dna apurinic or apyrimidinic site endonuclease activity 0.6811216172155348 0.5021261790637446 0.6155787662233045 1.0 0.9423317164155672 2 P78549 1 +Histone h3 tri di monomethyl lysine 4 demethylase activity 0.6775350505379845 0.4907963747098162 0.6235704743844834 1.0 0.9423317164155672 2 P29375 1 +Serine transmembrane transporter activity 0.5125661543639827 0.4839573874541749 0.6284161113628008 1.0 0.9423317164155672 4 Q96QD8 1 +Acetylgalactosaminyltransferase activity 0.656916432490357 0.4662706237631778 0.6410218031615118 1.0 0.9452394844513966 3 Q86SF2 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.656916432490357 0.4662706237631778 0.6410218031615118 1.0 0.9452394844513966 3 Q86SF2 1 +Acetylcholine receptor binding 0.6635148353439817 0.4475183662912088 0.6545008299739492 1.0 0.9515084230495788 2 Q15334 1 +Chloride channel inhibitor activity 0.648661121105041 0.4420879372396413 0.6584255730299964 1.0 0.9516739374887344 3 Q9H4A3 1 +Chloride channel regulator activity 0.648661121105041 0.4420879372396413 0.6584255730299964 1.0 0.9516739374887344 3 Q9H4A3 1 +Protein kinase a regulatory subunit binding 0.4084791317007712 0.4364001994716288 0.6625463942653318 1.0 0.9521123207685326 8 Q9ULX6,O43823 2 +Acyl coa oxidase activity 0.6414871128968804 0.4214797344059389 0.6734048064428353 1.0 0.9572251890220942 3 O15254 1 +Translation repressor activity 0.3951061525475356 0.4100888300627512 0.6817407862551552 1.0 0.9618866369572971 9 Q9BPZ3,Q14011,P00374,Q00577,Q5PRF9 5 +Camp dependent protein kinase regulator activity 0.6369242211103949 0.4085768971232902 0.6828501878830728 1.0 0.9618866369572971 3 P13861 1 +Aspartic type peptidase activity 0.636660143509455 0.4078351251382439 0.683394724099122 1.0 0.9618866369572971 3 Q8TCT9,Q5TDH0 2 +Oxidoreductase activity acting on nad p h 0.3173972264141877 0.4069345432275453 0.6840560644031206 1.0 0.9618866369572971 32 O43676,O96000,Q13423,O95831 4 +C palmitoyltransferase activity 0.64199543527877 0.3844695708151979 0.7006304450300189 1.0 0.9692070022167903 2 O15269 1 +Endopeptidase regulator activity 0.3103783038980762 0.3832249733312243 0.7015529628370676 1.0 0.9692070022167903 25 P51812,Q15418,Q9UL46 3 +Carbon sulfur lyase activity 0.4223379062128323 0.3823847843915751 0.7021759747430374 1.0 0.9692070022167903 6 P53701 1 +Telomeric dna binding 0.3300700811768854 0.3730064938949207 0.709143610776142 1.0 0.9694729005247736 18 Q14103,Q9NYB0,P12956,Q00577,P27695,P22626 6 +Rna 7 methylguanosine cap binding 0.3933384063993438 0.3705113092396208 0.7110015516547039 1.0 0.9694729005247736 8 Q53F19 1 +Aspartic endopeptidase activity intramembrane cleaving 0.6364525595043982 0.3689418760747537 0.7121710491844144 1.0 0.9694729005247736 2 Q8TCT9 1 +Camp binding 0.619777708521678 0.3615896459738461 0.7176587031732711 1.0 0.970991519730994 3 P13861 1 +Protein phosphatase 2a binding 0.3710044734320518 0.3485007938755423 0.7274641177203083 1.0 0.9787407191670838 10 Q86XL3 1 +Phospholipase binding 0.4714094740387832 0.34783435920157 0.7279645840993147 1.0 0.9787407191670838 4 P07196 1 +Glucosyltransferase activity 0.394068767829649 0.347301017627509 0.7283651863568996 1.0 0.9787407191670838 7 P04062 1 +Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor 0.3194396524013179 0.3449870380038735 0.7301041153978571 1.0 0.979165000133773 20 O94788 1 +Nf kappab binding 0.3491358774234844 0.3344044066187346 0.7380744146248925 1.0 0.9799342641094736 12 Q96JB5,O43823 2 +Protein demethylase activity 0.3841335103083878 0.3318500933966906 0.740002456495763 1.0 0.9799342641094736 8 O75151,Q8IUF8,Q8NB78,P29375,Q9H6W3 5 +Antiporter activity 0.3665409920237971 0.3282188077236269 0.7427462283254858 1.0 0.9799342641094736 10 Q9UBX3,P41440 2 +Mitochondrial ribosome binding 0.4642132197618712 0.3257844960326969 0.7445874097242404 1.0 0.9799342641094736 4 Q15070 1 +Alpha tubulin binding 0.4065122768590952 0.3235157694548763 0.7463046668030873 1.0 0.9799342641094736 6 P49354 1 +L serine transmembrane transporter activity 0.6023511808771099 0.316426970677575 0.751678448194137 1.0 0.9799342641094736 3 Q96QD8 1 +Endopeptidase activator activity 0.4153651444991835 0.2987465325059418 0.7651334496215667 1.0 0.9854472683285344 5 Q9UL46 1 +R smad binding 0.4544915502444697 0.2969345238552551 0.7665164979743144 1.0 0.9854472683285344 4 Q9UPN9,P17844 2 +Lipoprotein particle receptor binding 0.359102514250587 0.2951234322495344 0.7678995901579713 1.0 0.9854472683285344 10 Q07954,Q13492,O43813,P31689 4 +Oxidoreductase activity acting on the aldehyde or oxo group of donors 0.3080031581256024 0.2950886892242579 0.7679261299102285 1.0 0.9854472683285344 21 O94788 1 +C acyltransferase activity 0.3460316772456571 0.283780345512697 0.7765787175934085 1.0 0.9854472683285344 11 Q9BWD1 1 +Protein arginine n methyltransferase activity 0.4486133768352253 0.2800367723182782 0.7794492928483141 1.0 0.9854472683285344 4 Q86X55,O60678,Q99873 3 +Chaperone binding 0.3001013613224303 0.2784846602975414 0.7806403388075835 1.0 0.9854472683285344 39 O14976,O15212,Q13217,P62072,Q9UL15,Q14108,P02786 7 +N6 methyladenosine containing rna binding 0.4475547550573773 0.2770386739262738 0.7817504103808486 1.0 0.9854472683285344 4 P22626 1 +Wd40 repeat domain binding 0.4474140791847414 0.2766413174246465 0.7820555356211916 1.0 0.9854472683285344 4 Q96K76,Q16531 2 +D1 dopamine receptor binding 0.5853505173829215 0.2750876022503775 0.783248936251097 1.0 0.9860480661312988 3 Q15334 1 +S100 protein binding 0.3698011503854351 0.274048814183421 0.7840471087576311 1.0 0.9861506596439674 8 P50995 1 +Thiolester hydrolase activity 0.3087894547247016 0.2510000766859213 0.801814049899239 1.0 0.9939604798750926 18 Q9UMR5,P50897 2 +Fibronectin binding 0.58884903814802 0.2489906789664494 0.8033679915139698 1.0 0.9946407987940288 2 Q53GQ0 1 +Collagen binding 0.3591062553993169 0.2330282358081853 0.8157394802357905 1.0 1.0 8 Q92791 1 +Fatty acid binding 0.3581608186456672 0.2294953333230011 0.8184839473197234 1.0 1.0 8 O15254 1 +Fk506 binding 0.3615396715214167 0.2243367123435572 0.8224953117752367 1.0 1.0 7 Q9Y680 1 +Macrolide binding 0.3615396715214167 0.2243367123435572 0.8224953117752367 1.0 1.0 7 Q9Y680 1 +Molecular function inhibitor activity 0.3309262305311771 0.2172263529334892 0.8280319483138356 1.0 1.0 11 Q00577,Q9H4A3,P62942 3 +Carbohydrate derivative transmembrane transporter activity 0.3298808038679311 0.2127970072715922 0.8314852981377732 1.0 1.0 11 P41440,Q8TB61 2 +Single stranded dna endodeoxyribonuclease activity 0.5634170198891337 0.1956191544612618 0.8449082668398855 1.0 1.0 2 P49959 1 +Nuclease activity 0.2511397216978392 0.1940152469627812 0.8461639433910129 1.0 1.0 67 Q9UIV1,O00584,Q9BQ61,Q5RKV6,Q13868,Q8IV08,Q9Y3B8,Q15631,Q9UQ84,Q9BQG2,Q9NQT5,P78549,P15531 13 +S adenosylmethionine dependent methyltransferase activity 0.2880943265887647 0.1903065028465151 0.8490689582366213 1.0 1.0 39 Q08J23,P21964,Q96FX7,O60725 4 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.2838484114195442 0.1829656806750831 0.8548249468665756 1.0 1.0 29 Q9UIV1,Q13868,Q8IV08,Q9Y3B8,Q9UQ84,Q9NQT5 6 +C4 dicarboxylate transmembrane transporter activity 0.3752309884991903 0.1800129608580239 0.8571423931204225 1.0 1.0 5 Q9UBX3 1 +Transferase activity transferring sulphur containing groups 0.3750277150148862 0.1794739386385659 0.8575655790258865 1.0 1.0 5 Q7LGA3 1 +Polysome binding 0.5520052168242491 0.1742410857544484 0.8616759976000063 1.0 1.0 2 Q08211 1 +Signal sequence binding 0.2783596865470485 0.1728879343334836 0.8627395158456048 1.0 1.0 25 Q9Y584,P40855,Q92973,Q14978 4 +Nucleoside triphosphatase regulator activity 0.2531575979960786 0.1682636021667856 0.8663759068229369 1.0 1.0 72 P80303,O43924,Q14C86,P55010 4 +Oxidoreductase activity acting on a sulfur group of donors 0.2774665029223702 0.1675438079438631 0.8669421808846325 1.0 1.0 25 Q9UHG3,Q96JJ7,Q8N4Q1,Q6ZRP7,Q8IXB1 5 +Phosphoric ester hydrolase activity 0.2638017458631945 0.1658041775325704 0.8683110584356459 1.0 1.0 59 Q969T7,O60658,Q8IV08,P09601,Q9NPH0 5 +Cation channel activity 0.2854855683353417 0.1652798553463791 0.8687237138558759 1.0 1.0 21 O75964,P00846,P25705 3 +Mirna binding 0.3111121105524252 0.1618316832690994 0.8714384022594504 1.0 1.0 12 Q9BWF3,Q14671,P98175,P22626,P67809 5 +Monosaccharide binding 0.2773570838215708 0.1602058783554144 0.8727188989483059 1.0 1.0 26 Q5KU26,O75503,P11717,O15460 4 +Ribonuclease activity 0.2814161604520071 0.1511649409435067 0.8798456055162476 1.0 1.0 43 Q9UIV1,O00584,Q9Y3Z3,Q13868,Q5RKV6,Q9Y3B8,Q15024,Q9UQ84,Q9UKF6,Q9BQG2,O15091,Q9NQT5 12 +Rna polymerase core enzyme binding 0.2907844830651537 0.1496841231780023 0.8810138349143093 1.0 1.0 17 O95104,Q8N163 2 +Regulatory rna binding 0.2928900538820514 0.1487683744711009 0.8817364064064244 1.0 1.0 15 Q9BWF3,Q14671,P98175,P22626,P67809 5 +Protein macromolecule adaptor activity 0.2661108066305719 0.1417602630793005 0.8872693724755403 1.0 1.0 90 Q86VM9,O95721,Q8TD16,Q9P2W9,Q96CV9,P12270,Q13428,P45973,O95249,P46108,Q9UQB8,P56962,Q9UHI6,Q14978,P53680,Q86Y82,Q9BTX1,Q9UH99,Q86YP4,P56589,Q99747,Q07666,P35579,Q9UBV8,Q9P253,P07196,O00291,Q16531 28 +Metallocarboxypeptidase activity 0.3898282389619472 0.136442270962159 0.8914716587197966 1.0 1.0 4 O75976 1 +Cell cell adhesion mediator activity 0.2858519177492194 0.1337243320023234 0.8936205638136046 1.0 1.0 18 Q9NYL9,Q9UQB8,Q14126,P35613,Q08722 5 +Electron transfer activity 0.2699830622088988 0.1325780580352337 0.8945270863635235 1.0 1.0 53 Q9UDW1,P03915,O43674,O43676,O96000,P21912,P00403,O15121,O15460 9 +Smad binding 0.3014393965337001 0.1234678950508226 0.9017365957770518 1.0 1.0 12 P62942,Q9UNE7,P17844,Q00577,Q9UPN9 5 +3 5 dna helicase activity 0.3272125777566865 0.1231400028724932 0.9019962346046762 1.0 1.0 8 Q14566,P33993 2 +Dystroglycan binding 0.38140293637847 0.1199517580693836 0.9045213634176243 1.0 1.0 4 Q7Z460,Q15149,Q14118 3 +N acetyltransferase activity 0.2913198447039845 0.1093631743255288 0.9129144411392334 1.0 1.0 13 Q96QD8,Q969G3,Q86UY6 3 +Sodium ion binding 0.5089664166938312 0.1080568864650325 0.9139505674543204 1.0 1.0 2 O00764 1 +P type potassium transmembrane transporter activity 0.5089664166938257 0.1080568864650255 0.913950567454326 1.0 1.0 2 P05026 1 +Molybdopterin cofactor binding 0.5040756439517322 0.1019511040586566 0.918795486077978 1.0 1.0 2 Q5VT66 1 +Transferase activity transferring alkyl or aryl other than methyl groups 0.2674718773772609 0.1001321928228719 0.9202393775843224 1.0 1.0 23 P49366,P37268,P49354 3 +Phospholipase a2 inhibitor activity 0.4982067166612259 0.0949909087794871 0.9243220480104914 1.0 1.0 2 P07355 1 +Neurotrophin trk receptor binding 0.497554613628943 0.0942419583930276 0.9249169550939262 1.0 1.0 2 P62993 1 +Neurotrophin receptor binding 0.497554613628943 0.0942419583930276 0.9249169550939262 1.0 1.0 2 P62993 1 +Protein antigen binding 0.4903814802738703 0.0863205876855168 0.931211572951926 1.0 1.0 2 P30153 1 +Channel inhibitor activity 0.3273258041780624 0.085369636746362 0.9319675313841458 1.0 1.0 6 P62942 1 +Histone deacetylase binding 0.2655645502269035 0.0804328568138978 0.9358929955914326 1.0 1.0 28 Q14103,P52292,O43823,Q9ULX6,P23246 5 +Protein arginine omega n asymmetric methyltransferase activity 0.4742335290280393 0.0803126421082037 0.935988603746024 1.0 1.0 3 O60678,Q99873 2 +Glutathione disulfide oxidoreductase activity 0.4815780893381063 0.0773764945495778 0.9383240393439134 1.0 1.0 2 P00390 1 +Virion binding 0.4796217802412719 0.0755023658335216 0.9398150152487854 1.0 1.0 2 P07355 1 +Single stranded dna binding 0.2586702327453272 0.0754322447988694 0.939870804644226 1.0 1.0 56 Q96I24,Q96AE4,P33991,Q15631,Q14566,Q00577,P20585,P46100,P22626,P67809 10 +Protein tyrosine serine threonine phosphatase activity 0.3548743347945708 0.0750295247805452 0.9401912207156742 1.0 1.0 4 Q99956,Q13614 2 +Cullin family protein binding 0.3544890598983724 0.0744550149798512 0.9406483346124346 1.0 1.0 4 O60826 1 +Protein arginine omega n monomethyltransferase activity 0.4766873165960166 0.0727668907563758 0.9419916184332262 1.0 1.0 2 O60678 1 +Potassium channel regulator activity 0.3111319029117094 0.0706484736954443 0.9436775303358242 1.0 1.0 7 Q9H4A3 1 +Kinase inhibitor activity 0.2696540969594827 0.0618013539059069 0.9507210252896324 1.0 1.0 18 Q9Y3B8,O95684,Q9H4A3,Q13217 4 +Protein serine threonine kinase inhibitor activity 0.306136334028965 0.0582615732891206 0.9535402755695176 1.0 1.0 7 Q9Y3B8 1 +L aspartate transmembrane transporter activity 0.447488584474867 0.0534008900424029 0.957412496075138 1.0 1.0 3 Q15758,Q9UJS0 2 +Acidic amino acid transmembrane transporter activity 0.447488584474867 0.0534008900424029 0.957412496075138 1.0 1.0 3 Q15758,Q9UJS0 2 +Cell adhesion mediator activity 0.2645053255946585 0.0524093001652093 0.9582025638427014 1.0 1.0 20 Q9NYL9,Q9UQB8,Q14126,P35613,Q08722 5 +Insulin like growth factor receptor binding 0.4432485322896036 0.0497827449032754 0.9602955172044116 1.0 1.0 3 P61981,P46108 2 +Insulin receptor substrate binding 0.444734268014346 0.0484777883442415 0.9613354659586272 1.0 1.0 2 P62993 1 +Guanyl nucleotide exchange factor activity 0.2623232855750637 0.0472419252182328 0.9623204133139058 1.0 1.0 31 P80303,Q14C86 2 +Protein carboxyl o methyltransferase activity 0.435593673123176 0.043674463293892 0.9651638951271608 1.0 1.0 3 O60725 1 +Arachidonate coa ligase activity 0.3060387272170355 0.040709337679019 0.9675276173766548 1.0 1.0 6 P33121,Q9UKU0 2 +Long chain fatty acid coa ligase activity 0.3060387272170355 0.040709337679019 0.9675276173766548 1.0 1.0 6 P33121,Q9UKU0 2 +Acetyltransferase activity 0.2546224971505377 0.0361069090502907 0.971197113296266 1.0 1.0 26 Q969G3,O75600,Q86UY6,Q96QD8,Q9BWD1,Q8NF37 6 +Tat protein binding 0.3201350377985706 0.03183461708815 0.974603940174583 1.0 1.0 4 P31689 1 +Ankyrin binding 0.4164802989171917 0.030670423167827 0.975532378953882 1.0 1.0 3 Q01082 1 +Rna cap binding 0.278891286893829 0.0297949158566059 0.9762306135269648 1.0 1.0 11 Q53F19 1 +Hexokinase activity 0.3971307466579725 0.0276452511268541 0.9779450902626964 1.0 1.0 2 P52789 1 +Exoribonuclease activity producing 5 phosphomonoesters 0.2567890934982004 0.0271791515821161 0.9783168441903334 1.0 1.0 21 Q9UIV1,Q13868,Q9Y3B8,Q9UKF6,Q9NQT5 5 +Polynucleotide adenylyltransferase activity 0.3886534072383416 0.0253916696057776 0.979742555658858 1.0 1.0 2 P51003 1 +Complement component c1q complex binding 0.3084447342680154 0.0161133562561715 0.9871439581472116 1.0 1.0 2 Q07021 1 +Calcium dependent protein serine threonine phosphatase activity 0.3829093281148045 0.0146033783737413 0.9883486039883512 1.0 1.0 3 Q08209,P49593 2 +Histone kinase activity 0.2860912183216156 0.0135609357063371 0.9891802703937578 1.0 1.0 8 Q96GD4,P06493 2 +Protein kinase activity 0.2410663857233983 0.0135283372898493 0.9892062777812484 1.0 1.0 76 Q96GD4,O14976,O14936,Q9H2G2,P25440,P11717,P51812,Q15418,Q8NI60,Q9H4A3,P22392,Q14004,Q13464,Q14012,O14874 15 +Profilin binding 0.2937211548258389 0.0097075906714361 0.992254584932047 1.0 1.0 4 Q8N8S7,Q16643 2 +Nedd8 specific protease activity 0.3630136986301345 0.008385683376068 0.993309271117538 1.0 1.0 3 Q9BT78,Q92905 2 +Rna methyltransferase activity 0.2545821203830113 0.0040816554175047 0.9967433192025268 1.0 1.0 18 Q96FX7 1 +C3hc4 type ring finger domain binding 0.3206131767775604 0.0008562116564231 0.9993168420220307 1.0 1.0 3 P0DMV9,P31689 2 +Transferrin receptor binding 0.3176356409873528 0.0005417002450256 0.999567785759049 1.0 1.0 3 O95219 1 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f41750287a843620f1030eb64387834341775119 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 3 kinase regulator activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 cyclic amp phosphodiesterase activity", "3 5 cyclic gmp phosphodiesterase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5alpha androstane 3beta 17beta diol dehydrogenase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Activin binding", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Aminophospholipid flippase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Ap 2 adaptor complex binding", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp gated ion channel activity", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Bile acid transmembrane transporter activity", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbohydrate transmembrane transporter activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Copper ion transmembrane transporter activity", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Corticotropin releasing hormone receptor binding", "Crossover junction endodeoxyribonuclease activity", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D glucose transmembrane transporter activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Dehydroascorbic acid transmembrane transporter activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gap junction channel activity", "Gap junction hemi channel activity", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophosphodiester phosphodiesterase activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Icosanoid binding", "Identical protein binding", "Igg binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated cation channel activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Mutsalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Narrow pore channel activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neuropeptide receptor binding", "Neurotransmitter binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opioid receptor binding", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidic acid transfer activity", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 4 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphorylation dependent protein binding", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Platelet derived growth factor receptor binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Salt transmembrane transporter activity", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sugar transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Superoxide generating nadph oxidase activator activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type 5 metabotropic glutamate receptor binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AAMP", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPIF1", "ATR", "ATRX", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC137", "CCDC22", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLM", "GCN1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOPC", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS4", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1147", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MPV17", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFKB2", "NFU1", "NGEF", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTF1", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM201", "TMEM30A", "TMEM41B", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", 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2.59737357315436e-05 +Peripheral axonal degeneration 17 66 3.305391886591691 0.0009484368666525 16.691747572815533 71.19902912621359 0.6211832637355972 0.5650732986012978 6.425044282599762 8.4263916789636 0.8780908495791551 0.3675751486040735 0.0028790959603352 0.0417183769112744 0.0044489345386851 0.0019321231273462 0.0009726790002817 +Abnormality of head blood vessel 7 25 3.095629254528723 0.0019639575434577 7.512135922330097 24.881067961165048 0.5951213621611695 0.2501622891395578 2.541375726543966 2.628804376839775 1.8399520883426277 0.3043503409762604 0.000238642415863 0.002776216406037 0.0188000817445546 8.375063084086791e-05 0.0079827384799552 +Abnormal retinal artery morphology 7 22 3.0320600263649613 0.0024289089770757 6.985436893203883 21.733009708737864 0.6882820766413594 0.2247118762866906 2.318097134221824 2.0518941450352677 1.8438290687413053 0.2835525492265039 8.546933673396195e-05 0.0016433207319124 0.0115168854492612 2.159595199769763e-05 0.0025531684631581 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2.6876449833315994 0.0071957856344124 15.5873786407767 70.82038834951456 0.961917368584866 0.453560490665382 5.296970733704175 9.19591360516456 0.9682537043334576 0.378553967263451 0.2260377731536537 0.2792677388815299 0.3454913911187557 0.039757479465513 0.0705706835163868 +Mental deterioration 23 89 2.600616859578045 0.0093056319101647 26.16990291262136 97.51699029126212 1.0638646072845834 0.3178098854339388 8.217921866043707 8.355116022963852 1.9487627742005753 0.3762024781602087 0.0002802881002827 0.0009951056419742 0.0022397853800146 0.0002881739331835 0.000896346011382 +Abnormal cardiac ventricular function 7 16 2.596436185179686 0.0094196401408259 5.262135922330097 18.648058252427184 0.6561483334031016 0.4063512942618581 2.801563935800768 3.037775296806565 1.0608023601658336 0.302693194134391 0.3080434008088279 1.0 0.5140428615827085 0.2735886709753385 0.0301745479324052 +Increased cerebral lipofuscin 3 5 2.578269362902193 0.00992965610095 3.0970873786407767 5.118932038834951 1.0434065701738664 0.1270836154757583 1.1278862704044743 0.4599818751628888 1.7720117842909846 0.2267161680252343 8.82283563551478e-06 0.0009534063593398 1.4841791595772974e-06 5.99954180608972e-05 0.0009048869233579 +Abnormal peripheral myelination 11 30 2.5752368407162973 0.0100171468000154 7.635922330097087 32.13592233009709 0.6742900044491671 0.4743014543601314 3.568806451618386 4.873244854452022 0.9969709958674222 0.3457305187498817 0.0351041868051743 0.0071446844052079 0.0446017591208141 0.0152001873640661 0.0023250371259739 +Abnormal csf protein level 6 11 2.5735899127881483 0.0100649491182001 4.434466019417476 12.20631067961165 1.1239853500963992 0.2260559983233297 2.11400242863219 2.084072511592451 1.241935948510828 0.248039542652958 0.0193759682694979 0.0143944751365022 0.0057841877037216 0.0022315802511855 0.0104893431674361 +Abnormal pupillary function 1 7 2.5600120322838604 0.010466853929536 1.7985436893203883 6.25 0.9459174425459445 0.2892194993230557 1.1928988171245156 1.7202745886032773 1.109204161812943 0.2732247962160634 0.0757599364754171 0.0092510900433489 0.034177713847331 0.1691905711971676 0.4472297830188122 +Cherry red spot of the macula 4 9 2.549807662199735 0.0107782363526245 4.87621359223301 9.031553398058252 0.4125318500531191 0.1346012745180574 1.6566187440434876 0.4477283705000042 2.101542046986786 0.2228325403979826 2.032399806021117e-05 0.0550816697898294 0.1073692926764015 5.201511033931756e-06 0.0001560226497295 +Clumsiness 8 20 2.517265055332655 0.0118269818677736 6.75 20.57766990291262 0.9027704056640264 0.2559090219975202 2.4698423753801175 2.2221930931993956 1.527926415027724 0.282470536898918 0.005705824298765 0.0221752921749746 0.0011305823171555 0.0010432726477128 0.000495982234219 +Peripheral axonal neuropathy 12 53 2.5154143120382013 0.0118892574446607 13.890776699029129 56.6626213592233 0.647996206639266 0.5297865267121298 5.546380992609976 6.858150910061315 0.9851361073340408 0.3701043540632976 0.0141213291901167 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0.0148907893587964 0.0425821240391988 +Progressive visual loss 5 23 2.486902427632391 0.0128860735827081 5.325242718446602 22.429611650485437 0.7316954387450431 0.34231947196034 2.467466703195611 2.985791083259841 1.255625436621734 0.3056268024259221 0.0233991549692294 0.0473022522201117 0.0051349844611066 0.0319153810393969 0.148254160067468 +Impaired pain sensation 4 19 2.4842752449099765 0.0129815425789252 4.41747572815534 18.885922330097088 0.2391400027582448 0.5987828788006049 2.578944887904309 1.8718911764554207 0.7990438621947193 0.2974699433254886 0.0282335164695639 0.1916891885455893 0.0668951919761703 0.0042163593313455 0.0205399046658008 +Proximal muscle weakness 24 65 2.48363977367781 0.0130047286821886 14.951456310679612 61.769417475728154 0.5489884587613049 0.5295429242587456 5.9089016947638 6.961944869050214 0.9537081726509974 0.3546417916471885 0.3838840860794322 0.5122009359255594 0.417390658249379 0.0103346687147773 0.0001220912402762 +Juvenile onset 14 39 2.456945769081304 0.0140123837663526 10.220873786407768 41.28155339805825 0.3416766536043948 0.3540580800469471 3.658644665705508 2.990007551791468 1.4952530140825149 0.3282418399186692 0.0006622165874447 0.3776146865859943 0.0680937326262565 2.548392081052273e-05 5.382001706156264e-06 +Abnormal muscle fiber morphology 17 67 2.443736561190453 0.0145360363980195 17.78640776699029 68.04126213592232 1.263675841483234 0.3649599499596623 6.500784844979595 6.6307423444197315 1.1691802531751734 0.3853191125649093 0.0314918474836119 0.5350255113324144 0.0178382298163583 3.078243091527589e-05 0.0002844137445336 +Talipes calcaneovalgus 2 5 2.4362579117912397 0.0148400992491801 1.4902912621359223 4.922330097087379 0.9197709073874 0.3393743205084361 1.020376340538831 1.1900829732707392 0.926051379506817 0.2775113358333487 0.0072326589819844 0.04159641685533 0.0816476539699214 0.0010219748598928 0.0076273123324074 +Episodic vomiting 4 12 2.416390798959299 0.0156752273270328 4.179611650485437 11.12378640776699 1.060494846441687 0.2663322982599159 1.9809215871966128 1.7630834730718608 1.1982900451883365 0.2840581402107739 0.0757599364754171 0.1362745587685063 0.034177713847331 0.0060587135875955 0.0156507911863037 +Positive romberg sign 3 7 2.4094602196377166 0.0159761376308908 2.466019417475728 8.308252427184467 1.0733671875840938 0.3096488241780741 1.4485716699970723 1.6764009803624336 0.8283755892460324 0.2651507773538893 0.0199123159742315 0.0683810764565047 0.0085055091795532 0.0049774684437096 0.0048470794580564 +Respiratory failure 26 62 2.402973642553375 0.0162623595187583 15.308252427184469 64.92233009708738 0.6334303745407566 0.5052857133990365 5.520010364276267 5.289556151454055 0.9962199001839442 0.3695677120431103 0.0290882842919351 0.1702233046299462 0.0617473242092065 0.0136205077233935 0.0210911576003047 +Mixed demyelinating and axonal polyneuropathy 3 5 2.3934328086573298 0.0166915382622925 1.4757281553398058 3.861650485436894 1.0618051586825854 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0.0191581944434973 4.453883495145631 16.203883495145632 1.0855969203541704 0.3037117925086244 2.3812188822255287 1.5445439412417563 1.0118111691913367 0.2917679915833991 0.0221265682502345 1.0 0.3220142659994904 0.0161985279427134 0.0032176405980257 +Abnormal oral physiology 15 52 2.324272224441252 0.0201109084925248 13.310679611650484 56.70631067961165 0.2724885602623864 0.6489080290207052 5.136541706554766 4.917144465020927 0.8216540240422228 0.3356242120899859 0.0961955429787034 0.5438595681423013 0.2032052119469528 0.0446322155306686 0.0062747292094077 +Ulnar claw 2 5 2.323905867408476 0.0201305397307121 1.1605839416058394 3.462287104622871 0.663214291352932 0.3472481829384642 0.8787868488313123 0.9743242091468184 1.2126112457762002 0.2783949343765722 0.0031023097734693 0.0279227766388577 0.0551927725411792 0.0002566819155387 0.0020257428393968 +Young adult onset 3 10 2.3090881319083216 0.0209386911998714 3.936893203883495 11.097087378640778 0.9326277418903632 0.2839315553797075 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5.404579245979259e-06 2.883936627511418e-05 +Excessive salivation 8 26 2.2789448072076515 0.022670346416119 6.720873786407767 28.725728155339805 0.070419154064915 0.6843354752968681 3.2143868360299983 3.4808795624155437 0.6713448234508642 0.2826176296417952 0.1329906134963605 0.3347057085815983 0.1940719369188673 0.0550195483409637 0.0229849220039357 +Ectrodactyly 5 14 2.277681087437341 0.0227455853498428 4.12378640776699 15.87864077669903 0.8198140763126681 0.3757221931635416 2.0209382693093176 2.284355849612238 1.0264971379648948 0.291688305539228 0.1569222414358129 0.2031027035797352 0.3656394840660639 0.1069666031552264 0.0813065502215209 +Chronic fatigue 1 5 2.2750849469241765 0.0229008344934327 2.0800970873786406 7.354368932038835 0.6505903571445167 0.3551914870642563 1.248646642239502 1.3902068505046723 1.081635717396615 0.2816956203568134 0.0312118869909902 0.0858288536093336 0.0135177788357734 0.0746908244780269 0.2341882727805034 +Psychomotor deterioration 3 9 2.269096364612165 0.0232624664067506 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 2.902155080481066e-05 2.7096103204179448e-05 0.0002160518736796 0.0001929986818147 0.0002434795729679 +Abnormal fallopian tube morphology 0 5 2.268401048376482 0.0233047739391767 2.4733009708737863 7.269417475728155 -0.0684116476533065 0.6146002193666376 1.991917107659218 1.5209656649212553 0.738927824010415 0.2749648855731467 0.2784830937831226 1.0 1.0 0.4134158684498193 0.6650422428435531 +Abnormal electroretinogram 3 30 2.267219357661566 0.023376828875399 6.859223300970874 32.19417475728155 0.3723226242578533 0.5367764432246882 4.113037214139201 3.1846362137801685 0.9320732781642423 0.3371359118420042 0.0768282318775029 0.0145062062606783 0.0193710801222633 0.2642970906412284 0.613748499682195 +Ventricular preexcitation 3 7 2.255162725340923 0.0241231166501743 2.5145631067961167 6.497572815533981 0.9841118497305948 0.2225227126053997 1.468861772329754 1.5757549992030588 1.3097679632537274 0.2453287763295943 0.0312118869909902 0.0858288536093336 0.0135177788357734 0.0098793867189767 0.0118045746321095 +Emg chronic denervation signs 4 14 2.245861020756698 0.0247129112891362 4.550970873786408 13.815533980582524 0.6176194543661773 0.3415909714455588 2.199917039284479 1.6085184210885628 1.2249413291120588 0.2985007469873863 0.0480381407843038 0.1071891284628969 0.2033176172301104 0.0189056140649968 0.0051689545539866 +Emg neuropathic changes 6 24 2.227662576485016 0.0259030243654665 6.915048543689321 24.58252427184466 0.5887299592537784 0.4208819793990807 3.046574831105746 2.544837804909062 1.1306803597402475 0.3318248802653038 0.0041981932247113 0.018891152845815 0.0086239941031961 0.0042163593313455 0.0054986690042778 +Basal ganglia cysts 1 7 2.2263148420015786 0.0259931000172664 1.5436893203883495 6.509708737864078 0.6375864218957229 0.3423964855972016 1.553428397761971 0.5418441296142611 1.195152711044975 0.2990830010801169 0.0985740264627016 0.0325017468768143 0.0640938023600107 0.0110635085303117 0.0418361746391697 +Onion bulb formation 3 7 2.223654610934721 0.0261716912468892 2.349514563106796 7.970873786407767 0.5150646293879767 0.4549381092129949 1.538873234646762 1.9506350008138953 0.9326070078767312 0.299017222140306 0.2784830937831226 0.0987043131013681 0.1880666528119386 0.0963497504158291 0.0198699646710478 +Hyperconvex nail 1 7 2.216202926877132 0.0266776075262753 2.405339805825242 7.939320388349515 0.7351828941114927 0.3065172604341125 1.3467943353086171 0.7527989998960608 1.0793151443208264 0.2411455315204656 0.0128820657469678 0.0550816697898294 0.0054453582128303 0.0321406810264541 0.1121927202905578 +Muscle abnormality related to mitochondrial dysfunction 7 35 2.215333371722088 0.0267371908832476 11.12378640776699 35.58252427184466 0.9791864828781052 0.3365990386989574 4.6259837298613 4.333263242301439 1.4740065920951253 0.3430734831138388 0.0004028809602925 0.2683427616475903 0.0003782799451809 0.0009651341008377 0.0139364810386785 +Tinnitus 5 15 2.207903153076093 0.0272510250054738 3.8932038834951457 13.99514563106796 0.4805222542355059 0.4721664152250915 2.15835527708504 1.954575346364738 0.945493760855854 0.2980035751111249 0.0207260251816143 0.1723099894081314 0.0543070281832774 0.0700003041176641 0.0118494727859131 +Horizontal nystagmus 6 24 2.207087946243116 0.0273079157301883 6.274271844660194 23.053398058252423 1.1086320165192889 0.2915732095622053 2.6115907074401723 2.1860242554539786 1.3408731048130669 0.3129960018850027 0.0080492167010549 0.0265864003984115 0.0016281300184376 0.009176950922421 0.0147866199639627 +Abnormality of the tongue 35 86 2.206945713696054 0.0273178521858141 22.424757281553397 89.52912621359224 0.5421010507218363 0.5607339999720974 6.938472222740965 9.436122816051313 0.9593463898963266 0.3606735981467843 0.567981098302746 0.7263994255271469 0.7287210865419715 0.2020071088107435 0.0006725733761083 +Psychosis 8 22 2.1985707410924307 0.0279084593422727 7.441747572815534 29.73543689320388 0.4742861565216377 0.5201326315543127 2.950893373754939 3.867389997355917 0.8779517344338251 0.3210463988305211 0.0244431044490897 1.0 0.1570656494504584 0.0335533943028559 0.0703963670995082 +Biliary tract abnormality 10 23 2.193878491890824 0.0282441460112967 8.184466019417476 26.4004854368932 1.3038634098573934 0.2674323053300255 3.1080777089644696 2.335313487465734 1.3483489456318312 0.3101233364725878 0.0679264255370846 0.003335979694034 0.0222841926514129 0.1972610307320623 0.0344196216171049 +Thin ribs 5 13 2.189729459743488 0.0285438632253114 3.4101941747572817 12.966019417475728 1.1546097093245242 0.318018636886438 1.686379750034164 1.4240686548069037 0.806693252185275 0.2897104943533539 0.3872914697039186 1.0 0.2685126379615966 0.5509390944914208 0.0045472220952188 +Progeroid facial appearance 3 7 2.1788344408085383 0.0293439694220107 1.9514563106796117 7.388349514563107 0.6729672370065056 0.4005004632419714 1.5383678198214228 0.8728149940061183 0.919017314256916 0.2770141329353056 1.0 1.0 1.0 1.0 0.0078256896811826 +Hypocholesterolemia 2 8 2.175100604504594 0.0296225781826005 3.2645631067961167 8.048543689320388 1.205673434171466 0.2055905154190861 1.747510449264718 1.0646904903887575 1.232151298114248 0.2464368010987078 0.1753420255248594 0.0595353304203936 0.1157837219692003 0.0032412641391043 0.0224777557227792 +Pathologic fracture 4 12 2.1681904309572206 0.0301442005778045 4.257281553398058 15.072815533980584 0.983166532607372 0.3143076297274698 2.133145812327421 2.2800397788540345 1.0713003315034937 0.2893419439464214 0.1120281848821345 0.1683799151698467 0.0519022265935445 0.065867090511777 0.0387405426335318 +Decreased number of peripheral myelinated nerve fibers 5 15 2.1617143957851623 0.0306401973207641 4.269417475728155 15.449029126213592 0.5470641849851599 0.5309325631616826 2.362271543479177 2.3749959691588103 0.7924715482597077 0.3124068087690249 0.093373360218417 0.1524760813950871 0.2822673454343152 0.0505229741835546 0.0061413176576109 +Abnormal visual electrophysiology 5 45 2.151981484475084 0.0313988126858382 11.310679611650484 49.08009708737864 0.5738496712827478 0.4298926605512212 5.601714588788375 4.822166856762376 1.2686017151039417 0.3684491475281102 0.0194766707292982 0.0045868443184383 0.0023376824093557 0.1314449252176053 0.3976395249721389 +Abnormal macrophage morphology 2 5 2.1495609838602423 0.0315899573881646 2.9150485436893203 5.640776699029126 -0.1129741045260028 0.144980672561322 1.3090672390975422 1.117854819168669 1.9286041303300476 0.1913667515871486 0.0225400063340814 1.0 1.0 0.0060189869562698 0.0395358442373242 +Abnormal circulating lipid concentration 18 73 2.1483532411426403 0.0316857043507541 21.0995145631068 75.44417475728156 1.321442689138656 0.3287247628796158 8.33534407984455 6.5596064623065375 1.4065018349702674 0.365722219395451 0.1117186373578087 0.0087148422915659 0.02352212661787 0.0086554572024324 0.0002617532931736 +Diffuse white matter abnormalities 6 9 2.1464657684008137 0.0318358370301499 2.9514563106796117 8.87135922330097 0.5952845668725205 0.3852144131329246 1.9847899342355348 1.8774220853320651 1.0510828155917642 0.2960660984241839 0.3201079280732647 1.0 1.0 0.4677029294328743 0.1292339698967795 +Metatarsus adductus 3 11 2.144408200086267 0.0320001937999989 3.7694174757281553 13.25 0.9957104022100554 0.3572272245833284 1.816252583500775 2.104808410901558 0.7948300017734555 0.2882447196496276 0.3872914697039186 1.0 0.2685126379615966 0.186439254661641 0.2134840601212924 +Abnormal full field electroretinogram 2 7 2.13837851297478 0.0324860349531355 1.7985436893203883 7.135922330097087 0.8897551200199579 0.2742817695009352 1.2050451450005106 0.7670210145007976 1.1859557261264115 0.267107203595487 0.0480381407843038 0.0056070915236824 0.0211645746663273 0.1116515128715098 0.1078274882909933 +Abnormal light and dark adapted electroretinogram 2 7 2.13837851297478 0.0324860349531355 1.7985436893203883 7.135922330097087 0.8897551200199579 0.2742817695009352 1.2050451450005106 0.7670210145007976 1.1859557261264115 0.267107203595487 0.0343508900176433 0.0039064712270754 0.0149285353010988 0.0817208555303506 0.0698565063333662 +Supranuclear gaze palsy 4 15 2.1350649515262567 0.0327557050246052 5.186893203883495 19.1626213592233 0.8242716574954257 0.3183493558985887 2.2612229396433574 2.139608194404574 1.2188387108542005 0.2935859783151378 0.0193759682694979 0.1683799151698467 0.3090134871767957 0.0136518534395256 0.0387405426335318 +Hypoparathyroidism 4 14 2.131462530014543 0.0330510561824508 3.3907766990291264 12.677184466019416 0.6232545121271337 0.4810116180385506 1.8513213278290024 1.9719301655035288 0.837395541974523 0.306860352889589 0.067403767536045 0.1280604643503683 0.0302041354108555 0.0005590552185885 0.0118390941536887 +Abnormal middle phalanx morphology of the hand 3 7 2.131147352791892 0.0330770046713742 2.4563106796116503 7.589805825242719 0.5788196868209836 0.3824907194464522 1.617721633075034 1.3471267378138765 1.0880466646585885 0.2945011452106765 1.0 1.0 1.0 1.0 0.1267920275725256 +Impaired tactile sensation 1 8 2.121615373058283 0.0338700503645539 2.0800970873786406 7.844660194174757 0.3974848446712213 0.5051291165171002 1.725280894617257 1.4698080024763955 0.8897962544432779 0.3006087956437986 0.0409762817664239 0.0987043131013681 0.1880666528119386 0.0963497504158291 0.2890148794848829 +Redundant neck skin 1 7 2.1201354851400898 0.0339946211742281 2.012135922330097 6.883495145631068 0.5314347011399155 0.4673421570862101 1.448919349893566 1.2271283937048434 0.8858904059882734 0.2986427947662394 0.0253021270616913 0.0771453392642774 0.1486636480545473 0.0612683946998099 0.1979724457266636 +Slow decrease in visual acuity 2 9 2.1153964564680727 0.0343961715630989 2.313106796116505 7.985436893203883 0.7332483742783148 0.3617245659278226 1.567733834853386 1.5547551717475598 1.083959755774155 0.2999488674407273 0.3099309187147142 0.1114021565620111 0.2108364442764713 0.1195245041616155 0.1183493106079827 +Abnormal larynx physiology 5 13 2.109169287657022 0.0349299718843663 3.7694174757281553 14.78640776699029 0.7777362681295714 0.3936810823701626 2.010346212391085 1.51625807571557 0.9784109402665334 0.3028779878197117 0.097946622898163 1.0 0.2890484038757667 0.0103356771337591 0.007075120136557 +Anisocoria 0 5 2.108799025015426 0.0349619328130186 0.9174757281553398 4.461165048543689 0.5569455701691335 0.4690972952709908 1.195860756292305 0.6041495683308217 0.9122546461628256 0.3082539456267605 0.0851065069379356 0.0279227766388577 0.0551927725411792 0.1352957913069285 0.2577398980943645 +Muscle stiffness 3 22 2.1025504589484645 0.0355050844079691 5.109223300970874 19.216019417475728 1.2530133657268057 0.2695837776665858 2.5817154639007844 2.4582801786037667 1.0397164239726309 0.2961148999712332 0.0085832201668985 0.0275080115441885 0.0017432967444755 0.009902670774728 0.0489607488986235 +Gait ataxia 8 69 2.1024975007747164 0.0355097183482198 14.351941747572816 68.35194174757281 0.6787136514518399 0.4783255809544575 5.256980668043156 6.678826209042067 1.046898326537344 0.3693668840587258 0.0029889094791394 0.0010195063934252 0.0009119401057604 0.0062746087975631 0.0140100042984473 +Coarse hair 2 17 2.0985977277878862 0.0358523768369993 4.686893203883495 18.616504854368937 0.2343700701412837 0.5417146669091575 2.329949176130645 1.927954652781107 0.8671729178541636 0.2932988727143946 0.0221265682502345 0.1762218760282218 0.0567506627252609 0.0742478127624091 0.135456568067581 +Ragged red muscle fibers 4 16 2.0950914589872505 0.0361628630488823 5.233009708737864 17.730582524271846 1.450228655394427 0.2143723456093393 2.356374883616516 2.3878203593303375 1.2019998086948689 0.268108115907532 0.0024807455534365 0.1683799151698467 0.0004715704786335 0.0022315802511855 0.0387405426335318 +Infantile muscular hypotonia 13 67 2.090599143109875 0.0365640126371449 13.900485436893204 66.00242718446601 0.112520259201691 0.5910142955974006 6.420333276084778 7.344999879849499 0.9387709887425064 0.3382916955300774 0.0751588671245487 0.0350541036074757 0.1746657125342909 0.07450005841266 0.0163848494679803 +Hypersplenism 1 8 2.088828181018255 0.0367231926511109 2.7184466019417477 7.970873786407767 0.2142260937784027 0.1548364087136437 1.1589036979530396 1.1444786041391362 1.8316571038254568 0.2005205006822401 0.0225400063340814 0.0024970154667983 0.0096613748096581 0.0549051852836066 0.0395358442373242 +Pericardial effusion 2 6 2.085904978569894 0.0369872312358026 1.9466019417475728 5.980582524271845 0.6333430474464145 0.2773316461993735 1.2136213588737947 1.4646685732948297 1.3006352977804805 0.2635985168358294 0.2784830937831226 0.0987043131013681 0.1880666528119386 0.4134158684498193 0.0879711233989737 +Variable expressivity 23 80 2.082652789019187 0.0372828836963758 16.655339805825243 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0.8482653783663339 0.9836751774372468 0.270639905447839 1.0 1.0 1.0 1.0 0.0003260526470588 +Foot acroosteolysis 3 5 2.066738772820736 0.038758775569011 1.2572815533980584 4.723300970873787 0.7875306593292697 0.3485009649356967 1.1177388706060134 0.8482653783663339 0.9836751774372468 0.270639905447839 1.0 1.0 1.0 1.0 0.0001695148193701 +Periventricular white matter hyperintensities 2 8 2.064488934201389 0.038971382019906 2.978155339805826 8.604368932038835 0.7206271937008832 0.2495118997135797 1.313488091366194 1.3113693798075805 1.4898193087366574 0.2872267653893681 0.0199123159742315 0.0683810764565047 0.0085055091795532 0.048794410492492 0.033288888151673 +Retinal dysplasia 5 9 2.06102061451654 0.0393010734524763 2.6990291262135924 7.878640776699029 0.934970332417222 0.3353928049199215 1.4834684590696818 1.182325377441881 0.8740525348763903 0.2730031671079428 0.0444546103480301 0.1029565435856987 0.195727907115695 0.1039226879692455 0.0042587077964903 +Fasciculations 16 35 2.0555142826221955 0.0398293575770358 9.201456310679612 36.5 0.4731561459207285 0.4826265043963199 3.4648999783170837 3.557775567723639 1.0532476984865673 0.3454376907067654 0.2753010070433528 0.2821140734917597 0.140743998387736 0.0258700177938795 0.000498263287066 +Microcytic anemia 4 10 2.055054114594221 0.0398737781984672 2.441747572815534 8.526699029126213 0.6645628317552182 0.3838242289014166 1.6704179043327654 1.438636684975842 1.0496853438983738 0.3012783873714112 0.0444546103480301 0.1029565435856987 0.195727907115695 0.0168339060908118 0.0042587077964903 +Progressive psychomotor deterioration 5 8 2.0454464282327103 0.0408108656418002 3.349514563106796 8.320388349514563 0.5379615244672443 0.2176134167318772 1.5053866894387542 0.6226094824456632 1.5848775742530583 0.2457660654605461 0.0128820657469678 0.0550816697898294 0.1073692926764015 0.0321406810264541 0.0019736987849612 +Impaired temperature sensation 0 6 2.042133981544073 0.0411382429243945 1.6116504854368932 5.672330097087379 0.1150474698986732 0.3896360809799358 1.1211385484541423 0.8400828714131352 1.1248466433755278 0.2652914079698208 0.1505030705197739 0.0506073598520519 0.0988756314725496 0.2340005312196258 0.421069393435756 +Fatigable weakness of bulbar muscles 9 14 2.036485808384428 0.0417015967298146 4.063106796116505 15.25242718446602 0.7188062683419271 0.4547422847838221 2.248170358195387 1.4859761696395852 0.8778510505210118 0.3261836450387849 0.1265959661018035 1.0 0.3284235846140172 0.0786071704866826 0.0149334923888548 +Fluctuations in consciousness 4 7 2.020120743766392 0.0433708646553918 2.871359223300971 7.104368932038835 1.0899440920546752 0.2545542015295898 1.680977263462837 1.481694234866534 1.1451509420956862 0.2733842157028129 0.2456121138851051 1.0 0.16464692140167 0.0746908244780269 0.0615084186624239 +Erythema 5 18 2.017390450681383 0.0436547830237485 5.512135922330097 21.009708737864077 0.7860124479392929 0.4207309091489555 2.592436403423807 3.539637263054128 0.9160883902281578 0.3036972678357262 0.0177104249144926 0.2752604452820565 0.1343256297607796 0.0231451586112089 0.1106465000297166 +Abnormality of corneal stroma 6 11 2.016710297145078 0.0437257547206531 4.733009708737864 13.131067961165048 0.6716440045814968 0.2233795964932449 1.7589100966397004 2.506749302052849 1.61853564814875 0.2527544669587041 0.2153041836423196 1.0 1.0 0.0523525024013737 0.0649170986110887 +Mania 3 12 2.0152737399063176 0.0438759748466599 4.29126213592233 13.815533980582524 0.5633198814967983 0.4160552944360035 2.179476502394243 2.2801276272213657 1.0919629859527038 0.3085705503430486 0.0103767750184287 0.1362745587685063 0.0030035335028325 0.0060587135875955 0.0156507911863037 +Intellectual disability progressive 4 12 2.010663580115466 0.0443610033864922 3.645631067961165 12.516990291262136 0.6684697128447727 0.4789280824963769 2.065823454097857 2.417011447989348 0.7882243058155131 0.3050220610121475 0.0235776206214746 1.0 0.3284235846140172 0.0786071704866826 0.0509303706641057 +Vitiligo 1 7 2.007769311380902 0.0446678113747536 1.75 6.893203883495145 0.5228034908965178 0.4514214081097454 1.549545815072826 0.7902638291080828 0.9503325655279016 0.3007892778972581 0.2784830937831226 1.0 0.1880666528119386 0.0963497504158291 0.2890148794848829 +Aganglionic megacolon 5 16 2.005546254545828 0.0449046810323985 4.577669902912621 18.25728155339806 0.4558371355095859 0.5167976183070249 2.4238472202980517 4.014756807292137 0.8563808019734481 0.3054816181108372 0.1934416713307095 0.0845006677590773 0.2529967612296613 0.4491859221605753 0.7419846928899304 +Abnormal biliary tract morphology 9 21 2.003677742026805 0.045104592059598 7.427184466019417 23.174757281553397 1.329418499193971 0.249884151345828 2.8924137189053876 2.044064029481889 1.3393824039546371 0.2984385007787948 0.0428450117054736 0.0019447965050573 0.0134897524236001 0.1331815852696937 0.0134115286949534 +Central scotoma 3 11 2.000646009446661 0.0454305515969066 3.657766990291262 9.152912621359222 1.2790732929494344 0.2261272578521709 2.0233738200365714 2.077016218281829 1.2675536526802949 0.279373459017325 0.3301358347374786 0.1197698958477507 0.2256640636042331 0.0259302086121007 0.0394546172777071 +Increased bone mineral density 6 24 1.9939341864908144 0.0461592473239798 6.242718446601942 24.75 1.1480702818250033 0.3148175930983396 2.4533156459354677 2.2345749579547443 1.0849696139569316 0.312718333498069 0.0255148649049336 0.3022964060814402 0.0347044543068044 0.1086625136749498 0.0744768415084838 +Nasogastric tube feeding in infancy 3 7 1.9931522450403816 0.0462447785317698 3.0097087378640777 8.495145631067961 1.0003947416243104 0.2675726652756056 1.510449978803449 1.1668877069106371 1.1016283190777107 0.2724768109071007 0.3497529888008241 0.1280604643503683 0.2402159343378795 0.1522397567045821 0.0495301536946375 +Abnormal sensory nerve conduction velocity 0 6 1.9914824067708683 0.0464278775124957 1.7985436893203883 5.902912621359223 0.8037131919369849 0.3936255661985234 1.335002205566696 1.3883325411414074 0.8826639189987078 0.3019282509850424 0.222876020213352 0.0771453392642774 0.1486636480545473 0.3377423153713145 0.1979724457266636 +Mitochondrial myopathy 5 29 1.9886970675380156 0.0467346498728868 9.186893203883496 28.17233009708738 0.8747125393417822 0.3473011798108487 3.936575202939786 3.974666305559559 1.3336232032537867 0.3216890657230479 0.0009601979655909 0.2180755491779121 0.0014138667190371 0.0014309225606046 0.0387569851109487 +Abnormality of the alveolar ridges 2 7 1.9837525828873248 0.0472834285059025 2.1092233009708736 6.368932038834951 1.3424122348723253 0.2105791674194365 1.182482323454481 1.3741037061958896 0.9200079991465796 0.2386077675723682 0.067403767536045 0.1280604643503683 0.0302041354108555 0.1522397567045821 0.163813839479234 +Abnormality of glycolipid metabolism 4 7 1.9831437533643992 0.0473513745332037 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 0.0089540270958906 0.0461123069087121 0.0903020002145616 0.0226124222523767 0.0009048869233579 +Ankylosis 2 5 1.974916043862112 0.0482776763783467 1.7160194174757282 5.099514563106796 0.776290643053947 0.3289690792318075 1.1013829257517682 0.4264322039260138 1.078831323421012 0.282224813150681 1.0 1.0 1.0 1.0 0.0276005264132961 +Upper limb muscle weakness 8 25 1.971984745510268 0.0486113479466847 6.366504854368932 25.06553398058253 0.2420505902329557 0.6518430949396465 3.297416525876291 2.920978100633296 0.7195365671769505 0.3050196598378057 0.5961727314024635 0.2507644527164699 0.4394162360695961 0.4309620072073212 0.0739124968095968 +Hypoplastic vertebral bodies 3 6 1.971406917761088 0.0486773504238244 1.9757281553398056 5.771844660194175 0.8508946908089206 0.2775138956505893 1.1057630163966317 0.6800795892498206 1.1536023105486033 0.2559235656158802 0.1753420255248594 1.0 1.0 0.0373951204607401 0.1285045320310699 +Babinski sign 18 88 1.965396754290108 0.0493683348647933 19.08009708737864 87.19902912621359 0.4494221734255122 0.5751659127226604 6.9223075443198026 7.569689110667714 0.8530342054419842 0.3513302291959216 0.0039344456887286 0.0767004236414302 0.0036997050844839 0.0016725558710937 0.0031246841858853 +Increased connective tissue 3 7 1.9599924647441365 0.0499966710378816 2.5145631067961167 7.502427184466019 0.8156544766596637 0.4080201432400869 1.4337409663669696 0.673704389121222 0.9233752682577614 0.3237190879475042 0.2456121138851051 1.0 0.16464692140167 0.0746908244780269 0.0118045746321095 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2e7da720f7e73f48f48c4d97b143994aca84ee9b --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 4552, + "title": "Average number of proteins per term", + "value": 22.780316344463973 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c603be331036118b2fe0a6da9d225c2db57f9cbc --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2847980864555aad2a99867fb597af65a5730410 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1649 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sensorimotor neuropathy 0.7011644443688417 3.4135399349508817 0.0006412475983947 0.9460606685633648 0.5952506234859537 32 Q5KU26,Q9NR77,P07602,Q9Y2R0,O95831,P41440,P03915,P07196,P39210,P00846,P00403 11 +Peripheral axonal degeneration 0.511964226013609 3.305391886591691 0.0009484368666525 0.9866912457817713 0.5952506234859537 66 P50570,P07602,O95831,P41440,P02545,Q8IV08,P03915,P07196,P39210,Q15067,P00846,P00403,Q9BQT8,Q6DKK2,P22626,Q96BR5,Q9BPX6 17 +Abnormality of head blood vessel 0.6704870186432117 3.095629254528723 0.0019639575434577 0.9998700973293304 0.5952506234859537 25 P07602,P16278,P06865,P21964,Q13510,P00846,P10619 7 +Abnormal retinal artery morphology 0.6898564935273508 3.0320600263649613 0.0024289089770757 0.9999844249912736 0.5952506234859537 22 P07602,P16278,P06865,P21964,Q13510,P00846,P10619 7 +Demyelinating peripheral neuropathy 0.7247221008696263 2.8839197059522457 0.0039275888259664 0.999999983395399 0.5952506234859537 17 Q9NR77,P41440,P07196,P00846,O15121 5 +Peripheral demyelination 0.7120380636173513 2.7523296200627088 0.0059172928454409 0.9999999999981496 0.5952506234859537 16 Q9NR77,P07602,P50570,P17480,P03915,P07196,P00846,O43681 8 +Bulbar signs 0.7528191481037483 2.732484203669105 0.0062858685614475 0.9999999999996578 0.5952506234859537 13 P07602,P04062,P35637,Q15043,P03915,P00846,Q99720,O43681 8 +Contractures of the joints of the upper limbs 0.4559210786769711 2.6876449833315994 0.0071957856344124 0.9999999999999948 0.5952506234859537 66 Q9NR77,P16435,P37268,Q15392,P02545,P35637,P06753,P07196,Q99567,P23786,P41227,O75844,P50402,P42892,Q8IZA0,Q7LGA3,Q99720 17 +Mental deterioration 0.4702303552589429 2.6006168595780452 0.0093056319101647 1.0 0.5952506234859537 89 P21964,P00846,P21912,P27544,P07602,P35637,Q14108,Q9Y487,P50897,Q13510,O75503,P00403,Q03164,P22626,P35670,P54802,P16278,Q96F07,P06865,P03915,O15118,P04062,O43681 23 +Abnormal cardiac ventricular function 0.6853083247520628 2.596436185179686 0.0094196401408259 1.0 0.5952506234859537 16 P02545,P03915,P10253,O75844,P00403,P46100,Q15233 7 +Increased cerebral lipofuscin 0.9669368697897994 2.578269362902193 0.00992965610095 1.0 0.5952506234859537 5 O75503,P07602,P50897 3 +Abnormal peripheral myelination 0.5886807498231522 2.5752368407162973 0.0100171468000154 1.0 0.5952506234859537 30 Q9NR77,P07602,P50570,P02545,P17480,P03915,P07196,P39210,P00846,Q9H4A3,O43681 11 +Abnormal csf protein level 0.7700008194174549 2.5735899127881483 0.0100649491182001 1.0 0.5952506234859537 11 Q9NR77,P07602,P03915,P00403,Q16625,O43681 6 +Abnormal pupillary function 0.8713587905342671 2.5600120322838604 0.010466853929536 1.0 0.5952506234859537 7 Q9NR77 1 +Cherry red spot of the macula 0.8245012992298918 2.549807662199735 0.0107782363526245 1.0 0.5952506234859537 9 P07602,P06865,P16278,P10619 4 +Clumsiness 0.6335025607315944 2.517265055332655 0.0118269818677736 1.0 0.5952506234859537 20 Q9NR77,P07602,P35670,O75503,Q15067,Q13510,O14773,O43681 8 +Peripheral axonal neuropathy 0.5096690258840334 2.5154143120382013 0.0118892574446607 1.0 0.5952506234859537 53 P50570,P07602,O95831,Q8IV08,P03915,P07196,P39210,Q15067,P00846,P00403,P22626,Q9BPX6 12 +Abnormal pericardium morphology 0.7554319506766475 2.50002348601194 0.0124185073359737 1.0 0.5952506234859537 11 Q14108,P14174,O15460,P02545 4 +Abnormality of hepatobiliary system physiology 0.4496331832563171 2.4927059715391633 0.0126773778230719 1.0 0.5952506234859537 77 O43772,P22830,P39210,Q96A33,P00846,P55263,P46100,O15460,Q8N511,O75381,Q13510,P22695,Q6NUQ1,Q16625,P56589,P35670,P03915,P23786,O15118,P04062 20 +Hammertoe 0.6583842550761502 2.489619762376302 0.0127879826030907 1.0 0.5952506234859537 17 Q9NR77,P07196,Q99720 3 +Progressive visual loss 0.5960069583657124 2.486902427632391 0.0128860735827081 1.0 0.5952506234859537 23 O75503,P03915,P50897,P00846,O14773 5 +Impaired pain sensation 0.6385252324720613 2.4842752449099765 0.0129815425789252 1.0 0.5952506234859537 19 Q9NR77,O95831,P07196,P39210 4 +Proximal muscle weakness 0.4441001071475623 2.48363977367781 0.0130047286821886 1.0 0.5952506234859537 65 P51114,Q8TD16,P02545,Q9BUK6,P00846,P21912,Q8NFF5,Q9BPX6,P35637,Q13510,P36551,Q9Y5P6,Q8NI60,P50570,Q13126,P06753,Q8NAT1,P22626,P35670,P10253,P07196,P50402,Q9BQT8,Q99720 24 +Juvenile onset 0.5535241085626614 2.456945769081304 0.0140123837663526 1.0 0.5952506234859537 39 Q9NR77,P50570,P54802,P41440,P02545,P16278,O75027,P07196,P39210,Q14566,Q13510,Q03252,O15118,O14773 14 +Abnormal muscle fiber morphology 0.435688250934983 2.443736561190453 0.0145360363980195 1.0 0.5952506234859537 67 P50570,O95831,P35637,P02545,P61978,P03915,P07196,P23786,P00846,O14979,O43676,Q8NI60,P00403,P22626,Q70HW3,Q99720,Q9BPX6 17 +Talipes calcaneovalgus 0.9308765989621326 2.4362579117912393 0.0148400992491801 1.0 0.5952506234859537 5 Q9NR77,P07196 2 +Episodic vomiting 0.71733845442835 2.416390798959299 0.0156752273270328 1.0 0.5952506234859537 12 P61978,P03915,P00403,P00846 4 +Positive romberg sign 0.8367245444705601 2.4094602196377166 0.0159761376308908 1.0 0.5952506234859537 7 P07196,P41440,Q8IV08 3 +Respiratory failure 0.4538575846230582 2.402973642553375 0.0162623595187583 1.0 0.5952506234859537 62 O43819,Q8TD16,Q16637,Q96CV9,P07602,P35637,P33991,P43243,Q13510,Q9Y5P6,Q15165,Q5XKP0,P50995,Q70HW3,Q92734,P06753,Q8NBU5,Q8N183,Q9BT22,Q96EY7,P53701,Q92804,P10253,P23786,O75306,P43897 26 +Mixed demyelinating and axonal polyneuropathy 0.9201195828160412 2.3934328086573298 0.0166915382622925 1.0 0.5952506234859537 5 P35670,P07196,P00403 3 +Postural tremor 0.6329136424460186 2.388616533771356 0.0169119439273019 1.0 0.5952506234859537 18 Q9NR77,P35637,Q14108,P03915,Q9H6K4,P00846,O14773,O75569 8 +Toe walking 0.60312462826197 2.3854534869941686 0.0170580793212 1.0 0.5952506234859537 21 P07602,O95831,Q8TD16,P35637,P02545,P50402,Q99720,O43681 8 +Dementia 0.5078297435661387 2.379314206079099 0.0173448843072578 1.0 0.5952506234859537 50 P35670,P07602,P35637,Q14108,Q9Y487,P06865,P03915,P00846,Q13510,P00403,O15118,P27544,P22626,P04062,O43681 15 +Action tremor 0.4994528859232862 2.377242025620571 0.0174426391535156 1.0 0.5952506234859537 52 Q9NR77,P07602,Q99720,P41440,P35637,Q14108,Q9H6K4,O75027,P03915,P00846,Q5JRX3,O14773,Q15233 13 +Abnormality of the phalanges of the toes 0.662394130054675 2.3660484100217674 0.0179790933214973 1.0 0.5952506234859537 14 P02545,O14936,O75431,O75844,Q9H4A3,P98172,Q7LGA3 7 +Hemianopia 0.8023266893210397 2.3481441215250105 0.018867219333895 1.0 0.5952506234859537 8 P03915,Q9BVA1,P00403 3 +Amyotrophic lateral sclerosis 0.6507634625981852 2.342438435141336 0.0191581944434973 1.0 0.5952506234859537 15 Q92804,P35637,Q15165,Q96CV9,P22626,Q99720 6 +Abnormal oral physiology 0.4938839540579821 2.324272224441252 0.0201109084925248 1.0 0.5952506234859537 52 Q9NR77,Q96CV9,P35670,Q92804,P55795,P35637,Q9BVA1,Q92796,P51812,Q15165,P46100,P50995,O15460,Q03252,Q15233 15 +Ulnar claw 0.902768294494498 2.323905867408476 0.0201305397307121 1.0 0.5952506234859537 5 Q9NR77,P07196 2 +Young adult onset 0.7461513888223366 2.3090881319083216 0.0209386911998714 1.0 0.5952506234859537 10 O15118,P07602,Q14566 3 +Myoclonus 0.4455288319911016 2.3054171718856957 0.0211432206894663 1.0 0.5952506234859537 90 P00846,P27544,P07602,Q14108,P50897,Q13510,Q96CU9,Q8NI60,Q03252,O75503,Q13813,Q01105,P00403,O14773,Q969G3,Q96F07,P03915,Q00577,Q9UBX3,P04062 20 +Abnormality of salivation 0.532254905222543 2.3035861456311526 0.0212458862977584 1.0 0.5952506234859537 40 Q9NR77,Q96CV9,P35670,Q92804,P55795,P35637,Q9BVA1,Q92796,P51812,Q15165,P46100,Q03252,Q15233 13 +Slowly progressive 0.4786523467817147 2.3012765055115008 0.0213760068828186 1.0 0.5952506234859537 55 Q9NR77,P50570,O95831,O00584,P41440,P02545,Q8IV08,P07196,O14979,P50402,O43707,O14773,Q99720 13 +Segmental peripheral demyelination remyelination 0.8968668407310824 2.3001322169730622 0.0214407305518327 1.0 0.5952506234859537 5 Q9NR77,P03915,P07196,P00846 4 +Lacticaciduria 0.8947092694189296 2.2914245615501456 0.021938870363763 1.0 0.5952506234859537 5 P03915,O96000,P00846 3 +Hepatic failure 0.4971160545911011 2.279710309161094 0.0226248754753282 1.0 0.5952506234859537 50 P35670,O43772,O75381,P03915,P22830,P39210,P23786,P00846,Q13510,P56589,Q6NUQ1,P46100,O15118,O15460,P04062 15 +Excessive salivation 0.5540467294628456 2.2789448072076515 0.022670346416119 1.0 0.5952506234859537 26 Q9NR77,P35670,P55795,Q9BVA1,Q92796,P51812,Q03252,P46100 8 +Ectrodactyly 0.6472725891256955 2.277681087437341 0.0227455853498428 1.0 0.5952506234859537 14 Q9NR77,P07196,Q9H3P2,P48449,Q99720 5 +Chronic fatigue 0.8906663771005446 2.2750849469241765 0.0229008344934327 1.0 0.5952506234859537 5 P07602 1 +Psychomotor deterioration 0.7645691926196074 2.269096364612165 0.0232624664067506 1.0 0.5952506234859537 9 P07602,Q9Y487,P50897 3 +Abnormal electroretinogram 0.5479169500275227 2.267219357661566 0.023376828875399 1.0 0.5952506234859537 30 O43924,P50897,P00846 3 +Ventricular preexcitation 0.8018727951308328 2.255162725340923 0.0241231166501743 1.0 0.5952506234859537 7 P03915,P00403,P00846 3 +Emg chronic denervation signs 0.6418641584946218 2.245861020756698 0.0247129112891362 1.0 0.5952506234859537 14 P07602,P22626,P39210,Q13510 4 +Undetectable electroretinogram 0.9534137564807532 2.236183947812602 0.0253397242615966 1.0 0.5952506234859537 4 O43924,P50897 2 +Emg neuropathic changes 0.5486298318270878 2.227662576485016 0.0259030243654665 1.0 0.5952506234859537 24 Q9NR77,P07602,P39210,Q13510,O14773,P22626 6 +Basal ganglia cysts 0.7954267540848392 2.2263148420015786 0.0259931000172664 1.0 0.5952506234859537 7 P00846 1 +Onion bulb formation 0.794833413298362 2.223654610934721 0.0261716912468892 1.0 0.5952506234859537 7 Q9NR77,P07196,P02545 3 +Hyperconvex nail 0.793172353458106 2.216202926877132 0.0266776075262753 1.0 0.5952506234859537 7 P42892 1 +Muscle abnormality related to mitochondrial dysfunction 0.532977399962865 2.215333371722088 0.0267371908832476 1.0 0.5952506234859537 35 Q9Y2R0,P03915,P00846,O43676,Q96CU9,O96000,P00403 7 +Tinnitus 0.6282897791349995 2.2079031530760935 0.0272510250054738 1.0 0.5978406882203178 15 Q9NR77,Q969G3,O95831,Q15043,Q9NR28 5 +Horizontal nystagmus 0.5458442534138905 2.207087946243116 0.0273079157301883 1.0 0.5978406882203178 24 P07602,O95831,Q9H061,P00846,Q9NSE4,O14773 6 +Abnormality of the tongue 0.4335134348604185 2.206945713696054 0.0273178521858141 1.0 0.5978406882203178 86 P51114,P20700,P02545,Q16637,Q96A33,P21912,P98175,P07686,O43924,P46100,Q96CV9,Q9NQT5,O15460,Q7LGA3,Q10713,Q13428,P40855,O75381,Q13510,O75844,Q9Y5P6,Q03252,O95831,O75431,P04066,P56589,Q9H4A3,Q01082,Q969G3,P16278,O60826,P61978,P10253,P07196,Q9BQT8 35 +Psychosis 0.5657048851838483 2.1985707410924307 0.0279084593422727 1.0 0.6020820233460917 22 P03915,P51812,P36551,Q5JRX3,P00403,O15118,P16219,Q6DKK2 8 +Biliary tract abnormality 0.5547453891541086 2.193878491890824 0.0282441460112967 1.0 0.6047545022881401 23 P07602,P14174,P04062,P02545,O43681,Q14108,P09601,Q5XKP0,Q10713,O96028 10 +Thin ribs 0.6543005662096424 2.189729459743488 0.0285438632253114 1.0 0.6047545022881401 13 P50570,O95831,Q32P28,P02545,O75844 5 +Progeroid facial appearance 0.784863990120276 2.1788344408085383 0.0293439694220107 1.0 0.6071534036772414 7 O75844,P02545,Q03252 3 +Hypocholesterolemia 0.764789264636458 2.175100604504594 0.0296225781826005 1.0 0.6101446872723868 8 P07602,Q15800 2 +Pathologic fracture 0.6713578631479827 2.1681904309572206 0.0301442005778045 1.0 0.6120646698745579 12 P35670,Q14108,Q13126,P22626 4 +Decreased number of peripheral myelinated nerve fibers 0.6206504895625731 2.1617143957851623 0.0306401973207641 1.0 0.6166669368563507 15 Q9NR77,P50570,P02545,P07196,P39210 5 +Abnormal visual electrophysiology 0.5003657513840121 2.1519814844750833 0.0313988126858382 1.0 0.6166669368563507 45 P07602,O75503,P50897,P00846,O43924 5 +Abnormal macrophage morphology 0.8598518981580348 2.1495609838602423 0.0315899573881646 1.0 0.6166669368563507 5 O15118,P16278 2 +Abnormal circulating lipid concentration 0.4164152263845331 2.1483532411426403 0.0316857043507541 1.0 0.6166669368563507 73 P28070,P07602,P37268,Q8N511,Q15392,P02545,O43772,O75381,P22830,O75431,P23786,P56589,O75844,P50402,O43707,Q03252,P16219,Q15800 18 +Diffuse white matter abnormalities 0.7390037877244854 2.1464657684008137 0.0318358370301499 1.0 0.6166669368563507 9 P16278,O14936,P09471,O75306,Q9Y5P6,Q3ZCQ8 6 +Metatarsus adductus 0.6867594353306511 2.144408200086267 0.0320001937999989 1.0 0.6172240770237089 11 Q15392,Q08J23,Q03252 3 +Abnormal full field electroretinogram 0.7759090914268127 2.13837851297478 0.0324860349531355 1.0 0.6180224355122981 7 P50897,P00846 2 +Abnormal light and dark adapted electroretinogram 0.7759090914268127 2.13837851297478 0.0324860349531355 1.0 0.6180224355122981 7 P50897,P00846 2 +Supranuclear gaze palsy 0.6162601662050058 2.1350649515262567 0.0327557050246052 1.0 0.6180224355122981 15 O15118,P07602,Q99720,P35637 4 +Hypoparathyroidism 0.6225759277030436 2.131462530014543 0.0330510561824508 1.0 0.6180224355122981 14 P35670,P21964,Q08J23,P00403 4 +Abnormal middle phalanx morphology of the hand 0.7743127992786547 2.131147352791892 0.0330770046713742 1.0 0.6180224355122981 7 Q9UHX1,P02545,Q03164 3 +Impaired tactile sensation 0.7533377552281765 2.121615373058283 0.0338700503645539 1.0 0.6180224355122981 8 Q9NR77 1 +Redundant neck skin 0.7718844056478897 2.1201354851400898 0.0339946211742281 1.0 0.6180224355122981 7 Q9Y487 1 +Slow decrease in visual acuity 0.7325832561002826 2.1153964564680727 0.0343961715630989 1.0 0.6180224355122981 9 P03915,P00846 2 +Abnormal larynx physiology 0.6401906937927329 2.109169287657022 0.0349299718843663 1.0 0.6192479306025711 13 Q92804,P35637,Q13510,Q15165,Q96CV9 5 +Muscle stiffness 0.5521146834452259 2.1025504589484645 0.0355050844079691 1.0 0.6240935827069366 22 P07602,P53985,P00846 3 +Gait ataxia 0.4087166139010106 2.1024975007747164 0.0355097183482198 1.0 0.6240935827069366 69 Q9NR77,P07602,P41440,Q8IV08,Q14108,P07196,P00846,O14773 8 +Coarse hair 0.5954690090281475 2.0985977277878862 0.0358523768369993 1.0 0.6276277702867773 17 P51812,Q9Y487 2 +Ragged red muscle fibers 0.6025055805935307 2.0950914589872505 0.0361628630488823 1.0 0.6276277702867773 16 O95831,Q70HW3,P00403,P00846 4 +Infantile muscular hypotonia 0.405775353867279 2.090599143109875 0.0365640126371449 1.0 0.6276277702867773 67 P07602,Q969G3,P16278,Q15043,Q9Y487,Q9BVA1,O14936,P10253,P03915,P00846,Q13510,P46100,P16219 13 +Hypersplenism 0.746351845285534 2.088828181018255 0.0367231926511109 1.0 0.6276277702867773 8 P07602 1 +Pericardial effusion 0.8060832189148124 2.085904978569894 0.0369872312358026 1.0 0.6276277702867773 6 Q14108,P02545 2 +Variable expressivity 0.4175088749537022 2.082652789019187 0.0372828836963758 1.0 0.6276277702867773 80 Q9NR77,Q8TD16,Q13885,P02545,P41227,O43707,Q9NQT5,P07602,Q9H061,Q13868,Q9BVA1,Q13510,Q9Y5P6,Q8NI60,Q70HW3,P06753,Q13813,P00374,P00403,O15121,P03915,P07196,Q00577 23 +Hypothermia 0.7010159382548288 2.082649421400435 0.0372831908819393 1.0 0.6276277702867773 10 P03915,P20700,P00846,O43772 4 +Polyneuropathy 0.57654253640016 2.0817494465588866 0.0373653615438744 1.0 0.6276277702867773 19 P35670,P07602,O95831,P00846 4 +Osteolysis involving bones of the feet 0.8397487192387263 2.0667387728207354 0.038758775569011 1.0 0.6313086510840292 5 O75844,O75431,P02545 3 +Foot acroosteolysis 0.8397487192387263 2.0667387728207354 0.038758775569011 1.0 0.6313086510840292 5 O75844,O75431,P02545 3 +Periventricular white matter hyperintensities 0.7411823819870007 2.064488934201389 0.038971382019906 1.0 0.6313086510840292 8 O75503,P07602 2 +Retinal dysplasia 0.7213999638341483 2.06102061451654 0.0393010734524763 1.0 0.6343917955874907 9 P53701,O43505,Q8NAT1,O43924,P07437 5 +Fasciculations 0.5132657459621789 2.0555142826221955 0.0398293575770358 1.0 0.6355198256482228 35 O43819,P07602,P51114,O95831,Q8TD16,P35637,Q8NBU5,P06280,P07196,Q16637,Q13510,P07686,Q9BQT8,Q96CV9,Q9NQT5,P22626 16 +Microcytic anemia 0.6955934336978269 2.055054114594221 0.0398737781984672 1.0 0.6355198256482228 10 O75027,P22830,Q9BQT8,P46100 4 +Mitochondrial inheritance 0.9064725026916952 2.0538348729792792 0.0399916764615322 1.0 0.6355198256482228 4 P00403,P00846 2 +Foam cells 0.9064554211121872 2.053767910420187 0.0399981601672267 1.0 0.6355198256482228 4 O15118,P16278 2 +Progressive psychomotor deterioration 0.7371475688216147 2.0454464282327103 0.0408108656418002 1.0 0.6361394236711885 8 P07602,P16278,P21912,Q10713,O43681 5 +Fatigable weakness of bulbar muscles 0.6067418714079799 2.036485808384428 0.0417015967298146 1.0 0.6361394236711885 14 Q92804,P35637,P06753,P43243,Q15165,Q9Y5P6,Q96CV9,P50995,Q14203 9 +High frequency sensorineural hearing impairment 0.9014681892332737 2.0341986350522188 0.0419315721268849 1.0 0.6361394236711885 4 Q9NWM8,P02545,Q13510 3 +Fluctuations in consciousness 0.7499642229912458 2.020120743766392 0.0433708646553918 1.0 0.6361394236711885 7 P03915,P00403,P04062,O75306 4 +Erythema 0.5749977420233858 2.017390450681383 0.0436547830237485 1.0 0.6361394236711885 18 P53701,Q07954,P03915,P22830,P00403 5 +Abnormality of corneal stroma 0.6627671008301951 2.016710297145078 0.0437257547206531 1.0 0.6361394236711885 11 P10619,P16278,O43505,Q13510,Q16625,P04062 6 +Mania 0.6436570563566514 2.0152737399063176 0.0438759748466599 1.0 0.6361394236711885 12 P51812,P21964,P00403 3 +Intellectual disability progressive 0.6428289562363481 2.010663580115466 0.0443610033864922 1.0 0.6361394236711885 12 P53701,O95831,Q9H9P8,P46100 4 +Vitiligo 0.7472737814930215 2.007769311380902 0.0446678113747536 1.0 0.6361394236711885 7 P00403 1 +Aganglionic megacolon 0.5881855220400115 2.005546254545828 0.0449046810323985 1.0 0.6361394236711885 16 Q96EK5,P21964,P41227,P42892,P46100 5 +Abnormal biliary tract morphology 0.5475001775877117 2.0036777420268055 0.045104592059598 1.0 0.6361394236711885 21 P07602,P14174,P04062,P02545,Q14108,P09601,Q5XKP0,Q10713,O43681 9 +Central scotoma 0.659772222856387 2.000646009446661 0.0454305515969066 1.0 0.6361394236711885 11 P03915,Q9H061,P00846 3 +Loss of subcutaneous adipose tissue in limbs 0.8923327895595429 1.99825739264532 0.0456887621994306 1.0 0.6361394236711885 4 O75844,P02545,Q03252 3 +Abnormality of the distal phalanges of the toes 0.8923327895595389 1.998257392645304 0.0456887621994324 1.0 0.6361394236711885 4 O75844,Q7LGA3,P02545 3 +Widely patent fontanelles and sutures 0.8919168498189096 1.9966180624519956 0.045866689183291 1.0 0.6361394236711885 4 P98175,P02545 2 +Increased bone mineral density 0.5173244576074565 1.9939341864908144 0.0461592473239798 1.0 0.6361394236711885 24 Q13126,P54802,P02545,Q15043,Q14108,Q15392 6 +Nasogastric tube feeding in infancy 0.744094448675938 1.9931522450403816 0.0462447785317698 1.0 0.6361394236711885 7 P61978,P07602,Q9UHX1 3 +Mitochondrial myopathy 0.51318829451163 1.9886970675380151 0.0467346498728868 1.0 0.6361394236711885 29 P00846,O43676,Q96CU9,O96000,P00403 5 +Abnormality of facial adipose tissue 0.889684635786078 1.9878160119509083 0.0468320421997949 1.0 0.6361394236711885 4 O75844,P02545 2 +Abnormality of the alveolar ridges 0.7420525721796596 1.9837525828873248 0.0472834285059025 1.0 0.6361394236711885 7 Q15392,O43924 2 +Abnormality of glycolipid metabolism 0.741920387536754 1.9831437533643992 0.0473513745332037 1.0 0.6361394236711885 7 P07602,P06865,P06280,O43681 4 +Ankylosis 0.8176628312465942 1.974916043862112 0.0482776763783467 1.0 0.6361394236711885 5 O75844,P02545 2 +Upper limb muscle weakness 0.5139883356516665 1.971984745510268 0.0486113479466847 1.0 0.6361394236711885 25 P50570,Q969G3,P02545,P07196,P00846,P50402,P36551,Q9Y5P6 8 +Hypoplastic vertebral bodies 0.7797337998073506 1.9714069177610876 0.0486773504238244 1.0 0.6361394236711885 6 Q8TAA9,Q6NUQ1,P16278 3 +Babinski sign 0.4150306073823445 1.965396754290108 0.0493683348647933 1.0 0.6361394236711885 88 Q9NR77,P07602,O95831,P41440,P35637,Q15043,O75027,Q92796,P07196,Q15067,Q9H6K4,P00846,P51812,O15121,O14773,Q6DKK2,Q99720,O43681 18 +Increased connective tissue 0.736900282698953 1.9599924647441365 0.0499966710378816 1.0 0.6361394236711885 7 O95831,P07196,P02545 3 +Deep palmar crease 0.6329809983204053 1.9556679944020023 0.0505042773640365 1.0 0.6361394236711885 12 P61978,Q9Y487,P98175 3 +Skin nodule 0.5571953750714116 1.9525410535763512 0.0508740018086537 1.0 0.6361394236711885 19 P34913,P35637,P06280,Q13510,P16615,P21912,Q9NSE4,P48735 8 +Areflexia of lower limbs 0.5482271856134986 1.9479386834646324 0.051422300415022 1.0 0.6361394236711885 20 Q9NR77,P50570,Q13217,Q9H6K4,P07196,Q15067,Q16637,Q13586,O75477 9 +Hyperintensity of cerebral white matter on mri 0.5482265720739665 1.9479344647604944 0.0514228052660958 1.0 0.6361394236711885 20 P07602,P20700,Q15043,P17480,O75503,P10253,P21912,O43681 8 +Bilateral sensorineural hearing impairment 0.5101469495761856 1.94672643049891 0.0515675411543647 1.0 0.6361394236711885 26 P07602,P35637,P03915,Q15067,P38159,Q9NSE4,P00403,O43681 8 +Sclerocornea 0.7155952765896557 1.9430592061424097 0.0520090051726787 1.0 0.6371103319388072 8 P53701,O75569,Q9H3P2 3 +Postural instability 0.5628669855934688 1.9377905754033549 0.0526487780621929 1.0 0.6371103319388072 18 Q9NR77,P41440 2 +Cardiac valve calcification 0.8763458401305041 1.935069087239218 0.0529818183206596 1.0 0.6371103319388072 4 O75844,O75431,P02545 3 +Mitral valve calcification 0.8763458401305041 1.935069087239218 0.0529818183206596 1.0 0.6371103319388072 4 O75844,O75431,P02545 3 +Abnormal retinal vascular morphology 0.4640606436035016 1.9344668976286552 0.0530557482290154 1.0 0.6371103319388072 49 P07602,P16278,P06865,P21964,Q13510,P00846,P10619 7 +Retinal telangiectasia 0.7698470727603896 1.9280901321010064 0.053843916176681 1.0 0.6371103319388072 6 P00846 1 +Severe short stature 0.5443540976588276 1.921273381366664 0.0546972511379626 1.0 0.6371103319388072 20 P53701,Q15392,P16278,P10619 4 +Abnormality of lipoprotein cholesterol concentration 0.5875259124185985 1.919954648287567 0.0548636281735099 1.0 0.6371103319388072 14 P37268,Q15800,Q8N511,P02545 4 +Abnormal circulating citrulline concentration 0.8044800480504031 1.919702079730764 0.0548955414114074 1.0 0.6371103319388072 5 P00846 1 +Left ventricular systolic dysfunction 0.8040909807872362 1.9180680047428436 0.0551023887879047 1.0 0.6371103319388072 5 P02545 1 +Hypoplasia of the musculature 0.8030391201975253 1.913648921790334 0.0556650296202723 1.0 0.6371103319388072 5 Q9NR77 1 +Atrophy degeneration involving the spinal cord 0.7664892461960142 1.9133351138723889 0.0557051652266356 1.0 0.6371103319388072 6 P07196,Q13217 2 +Aspiration pneumonia 0.5055715262942215 1.9114799860008236 0.0559429263808368 1.0 0.6381941886325201 26 Q92734,P78318,Q969G3,P20700,O95721,P16278,P06753,Q13510,O60220,O14497,Q00577,Q92785,Q96EY7,P04062 14 +Scotoma 0.5859620680043112 1.9104108657333363 0.0560803329202566 1.0 0.6381941886325201 14 Q9H061,P03915,Q9H6K4,P04439,P00846 5 +Abnormal motor nerve conduction velocity 0.5425543910917975 1.9088598406486896 0.0562801748410182 1.0 0.6388712116616332 20 Q9NR77,P07196,Q99720,O15121 4 +Abnormal astrocyte morphology 0.584770600576899 1.9031336164946064 0.0570231124811388 1.0 0.6432499256961803 14 O95831,P48735,P00846 3 +Decerebrate rigidity 0.8676076293801503 1.9003781026608977 0.0573835184236237 1.0 0.6432499256961803 4 P07602,P16278 2 +Abnormality of pain sensation 0.50443109403437 1.8989109201126095 0.0575761893046056 1.0 0.6432499256961803 25 Q9NR77,O95831,P07196,P39210 4 +Focal segmental glomerulosclerosis 0.5408992806259059 1.897430859312719 0.0577710960018897 1.0 0.6432499256961803 20 Q8N1F7,Q14C86,Q14108,P03915,Q8NFH4,O75431,P00403 7 +Abnormal ldl cholesterol concentration 0.6031939843579261 1.8946119089551936 0.0581438358965291 1.0 0.6432499256961803 13 P37268,Q15800,Q8N511,P02545 4 +Abnormality of the tonsils 0.7227539922979165 1.894450435065338 0.0581652473915041 1.0 0.6432499256961803 7 P21964 1 +Metaphyseal striations 0.7983134063145867 1.893772100412523 0.0582552663865447 1.0 0.6432499256961803 5 P00813 1 +Hypoglycemic seizures 0.760349179148984 1.8862980743853517 0.059254798627911 1.0 0.6468293605617532 6 P53985 1 +Osteoarthritis 0.6196417559520873 1.880679578334586 0.0600155192865818 1.0 0.6504554581471527 12 P35670,P02545,Q14108,O75844,Q96HY6 5 +Motor neuron atrophy 0.5296294999840118 1.87783621460075 0.0604035744188706 1.0 0.6504554581471527 21 Q92804,P35637,Q13510,Q15165,Q96CV9,P22626,Q99720 7 +Decreased activity of mitochondrial complex iv 0.574281737560952 1.876457990556844 0.0605924180358905 1.0 0.6504554581471527 15 Q9Y2R0,Q70HW3 2 +Abnormal visual field test 0.7936737440051469 1.874220677656982 0.0609000152527741 1.0 0.6504554581471527 5 P00846 1 +Left ventricular hypertrophy 0.5290574392264857 1.873783237090122 0.0609603077606584 1.0 0.6504554581471527 21 P10253,P06280,P03915,O75431,P21912,P00403,Q15233 7 +Abnormal tissue metabolite concentration 0.5735555267110289 1.871925012482765 0.0612169786095591 1.0 0.6504554581471527 15 P40855,P07602,O75381,P06865,P56589,O43681 6 +Elevated pulmonary artery pressure 0.5286809841181125 1.871115280003796 0.0613291041126298 1.0 0.6504554581471527 21 P02545,P25705,Q14108,P03915,O75844,O96000,P00403,Q8IZA0 8 +Limb ataxia 0.5001409882347142 1.8694994152773616 0.0615533649122213 1.0 0.6504554581471527 26 Q9NR77,P41440,Q8IV08,Q14108,O14773 5 +Optic neuropathy 0.5006868232433702 1.8675252540211185 0.0618282735417781 1.0 0.6504554581471527 24 O43676,Q96CU9,O96000,P00846 4 +Unusual infection by anatomical site 0.572635593217267 1.866180017331037 0.0620161838391617 1.0 0.6504554581471527 15 Q14739,P02786,Q9H9P8,P46100,Q8TAA9,O15460 6 +Progressive gait ataxia 0.6586556934428554 1.8648864441330888 0.0621973229477623 1.0 0.650855664501642 10 P07602,P00846 2 +Neck muscle weakness 0.5974994603368591 1.8611696614726372 0.0627202212548554 1.0 0.6541764583938929 13 P07602,P35637,P02545,P06753,Q99720 5 +Sensory axonal neuropathy 0.6160850285535319 1.860590059341665 0.0628020897008196 1.0 0.6541764583938929 12 O95831,Q15067,Q8IV08 3 +Distal muscle weakness 0.4050551146633662 1.857387091505989 0.0632561016615735 1.0 0.6559620692645652 62 Q9NR77,P50570,O95831,Q8TD16,P41440,P02545,P35637,P07196,P39210,P00846,Q9BQT8,P22626,Q96BR5,Q99720 14 +Impaired proprioception 0.48526137980808 1.8522622369063857 0.0639881755748372 1.0 0.6559620692645652 37 Q9NR77,P54802,P41440,Q8IV08,P00846,O14773 6 +Abnormality of pulmonary circulation 0.49865514340849 1.8519883765292189 0.0640274920239261 1.0 0.6559620692645652 24 P02545,P25705,Q14108,P03915,O75844,O96000,P00403,Q8IZA0 8 +Episodic tachypnea 0.7133465436879607 1.8506197482421405 0.0642242766255996 1.0 0.6559620692645652 7 P22695,O43924 2 +Distal lower limb amyotrophy 0.5954582839201005 1.849156049837339 0.0644352829084786 1.0 0.6559620692645652 13 Q9NR77,P07196,Q8TD16,P02545 4 +Hypopigmented skin patches 0.5167909870423146 1.848621053023332 0.0645125505323234 1.0 0.6559620692645652 22 P07602,P21964,P53701 3 +Joint contracture of the hand 0.4693584372211377 1.847483707611823 0.0646770672540637 1.0 0.6559620692645652 44 Q9NR77,Q15392,P02545,Q8IZA0,P06753,P07196,Q99567,P41227,O75844,P42892,P98172,P16435 12 +Deep plantar creases 0.7863536136819187 1.8433010928127491 0.0652850616868665 1.0 0.6560211938159304 5 Q9Y487 1 +Abdominal pain 0.3953046198796476 1.8373724379819265 0.066154932806953 1.0 0.6562655373765833 78 P14174,Q14C86,O14936,P21912,O43707,P42892,P46100,O15460,P35637,Q14108,P36551,Q70HW3,P50336,P57740,Q8NFH4,Q13423,Q01082,Q8N1F7,Q6UN15,P06280,P23786,Q14566,Q01844,P04062 24 +Abnormal circulating non proteinogenic amino acid concentration 0.7073531284728767 1.822595463487775 0.068364683232017 1.0 0.6562655373765833 7 P00846 1 +Fatigable weakness of swallowing muscles 0.6091392151077574 1.8212446541352996 0.0685696753819693 1.0 0.6562655373765833 12 Q15165,Q92804,P35637,Q96CV9 4 +Retinal arteriolar tortuosity 0.6264164133542071 1.8199077009265745 0.0687730619796316 1.0 0.6562655373765833 11 P21964 1 +Premature rupture of membranes 0.7451070783404397 1.8188718436531053 0.0689309843878676 1.0 0.6562655373765833 6 Q9Y487,P02545 2 +Paresthesia 0.5032657529610062 1.8155560471067933 0.0694385010791547 1.0 0.6562655373765833 23 Q9NR77,P07196,O15460,P54802 4 +Psychotic mentation 0.8463222384358121 1.8154371340189377 0.0694567587915115 1.0 0.6562655373765833 4 P00403 1 +Tremor by anatomical site 0.4935119706033148 1.8148285620641 0.0695502596118295 1.0 0.6562655373765833 25 Q9NR77,P07196,Q99720 3 +Subcutaneous nodule 0.5579044336739514 1.8135270071452112 0.0697505770325759 1.0 0.6562655373765833 16 P35637,Q13510,P21912,Q9NSE4,P48735 5 +Aplasia hypoplasia involving the skeletal musculature 0.6244206450859625 1.8089900329037665 0.0704525518230909 1.0 0.6562655373765833 11 Q9NR77,Q9Y487,Q8NAT1,P06753 4 +Respiratory arrest 0.7426895497332673 1.8081376056279852 0.0705850865989692 1.0 0.6562655373765833 6 O43772 1 +Abnormal tongue physiology 0.550270993846416 1.8074636467745864 0.0706900179355491 1.0 0.6562655373765833 17 O95831,P10253,Q13510,Q9BQT8,Q96CV9,Q9H4A3,Q9NQT5 7 +Symptomatic seizures 0.7040825811803861 1.8072704587621191 0.0707201197271543 1.0 0.6562655373765833 7 P53985 1 +Oromandibular dystonia 0.8439842086225658 1.8060703905847713 0.0709073451611428 1.0 0.6562655373765833 4 P35637,Q99720 2 +Fatigable weakness of respiratory muscles 0.5881268712208627 1.8058926542184823 0.0709351087493324 1.0 0.6562655373765833 13 Q15165,Q92804,P35637,Q96CV9 4 +Abnormal tongue morphology 0.3807563647404317 1.798802767823701 0.0720498853625943 1.0 0.6562655373765833 66 P20700,P02545,Q96A33,P21912,P98175,P07686,O43924,P46100,Q9NQT5,O15460,Q7LGA3,Q10713,Q13428,O75844,Q9Y5P6,Q03252,O75431,P04066,Q01082,P16278,O60826,P61978,P10253,P07196 24 +Capillary hemangioma 0.7399621092601956 1.796014419453254 0.0724922237897307 1.0 0.6562655373765833 6 Q7LGA3,Q9UHX1 2 +Distal lower limb muscle weakness 0.5339263183723555 1.7949842299432892 0.0726562125495444 1.0 0.6562655373765833 19 Q9NR77,P07196,P00846 3 +Abnormal circulating cholesterol concentration 0.4885913195059858 1.7944166862284223 0.0727466855607066 1.0 0.6562655373765833 29 P07602,P34913,P37268,Q8N511,P02545,Q15904,O75431,P57740,P50402,Q15392,Q15800 11 +Xerostomia 0.5666293352307019 1.7917000735369883 0.0731810227650004 1.0 0.6562655373765833 14 Q92804,Q14739,P35637,P43243,Q15165,Q96CV9,P50995,Q14203 8 +Neoplasm of the tongue 0.700694158248818 1.791369198970742 0.0732340682541143 1.0 0.6562655373765833 7 O43924 1 +Aplasia hypoplasia involving the nose 0.4901612547483124 1.786802583602755 0.073969401642699 1.0 0.6562655373765833 24 Q5KU26,P55795,P02545,P61978,O75431,O75844,Q08J23 7 +Abnormal metabolic brain imaging by mrs 0.5523319593088927 1.7778099459497283 0.0754350744257792 1.0 0.6562655373765833 16 O43819,P07602,P03915,O75306,P21912,P00403 6 +Dystrophic toenail 0.7352114727624534 1.7748660028379273 0.0759200149642282 1.0 0.6562655373765833 6 O75844,Q969G3,P02545 3 +Joint swelling 0.6962112631586771 1.7702947180957085 0.076678057511361 1.0 0.6562655373765833 7 P35670,Q13510 2 +Abnormal iliac wing morphology 0.6404145296466891 1.769605598624277 0.0767928655566452 1.0 0.6562655373765833 10 P51812,O95831 2 +Global brain atrophy 0.5292385411215318 1.7629692437290465 0.0779056771294803 1.0 0.6562655373765833 19 P07602,Q9H9P8,P35637 3 +Delayed cranial suture closure 0.485268420284379 1.7622028802464542 0.0780350256490609 1.0 0.6562655373765833 28 P40855,Q32P28,P02545,O75381,Q9Y487,O75431,O75844,P51812,Q08J23,P16435 10 +Arthritis 0.4686644226645819 1.7587590324670337 0.0786184458900538 1.0 0.6562655373765833 40 P28070,P35670,P14174,P02545,Q14108,P21964,Q13510,O75844,P10321,Q96HY6,O15460 11 +Proximal muscle weakness in upper limbs 0.5610303451137647 1.7570746691064292 0.0789050827193085 1.0 0.6562655373765833 14 P50570,P02545,P07196,P50402,P36551,Q9Y5P6 6 +Abnormal exteroceptive sensation 0.4454658745618562 1.7562021590404708 0.0790538961897617 1.0 0.6562655373765833 49 Q9NR77,P07602,O95831,P54802,P61978,P17480,Q9H6K4,P07196,P39210,Q9H4A3,O15460 11 +Toxemia of pregnancy 0.7304948305305641 1.753828743469224 0.0794598562920099 1.0 0.6562655373765833 6 P49366,Q01082,P02545,O43772 4 +Submucous cleft of soft and hard palate 0.4950152931053748 1.7536736957324337 0.0794864352547408 1.0 0.6562655373765833 23 P02545,O75844,Q8NAT1,Q15392,Q08J23,Q7LGA3 6 +Autoamputation of digits 0.8308176420251692 1.7531917255663525 0.079569102854768 1.0 0.6562655373765833 4 P39210 1 +Acral ulceration 0.8308176420251692 1.7531917255663525 0.079569102854768 1.0 0.6562655373765833 4 P39210 1 +Cachexia 0.5350414454788314 1.752904814962377 0.0796183469870166 1.0 0.6562655373765833 18 P07602,P35637,P02545,Q01844,Q99720 5 +Foot dorsiflexor weakness 0.4814167489680816 1.751203451489424 0.079910871159901 1.0 0.6562655373765833 31 Q9NR77,P02545,P07196,P39210,Q9BQT8,Q96BR5,Q99720 7 +Disproportionate short stature 0.5115429624407937 1.7489809995799122 0.0802943038160375 1.0 0.6562655373765833 21 Q32P28,P16278,Q96HY6,Q15392,Q7LGA3,Q9UHX1 6 +Bilateral cryptorchidism 0.6355293836455689 1.7439410817870906 0.081169364103381 1.0 0.6562655373765833 10 P37268,P48449,O43924,Q15233 4 +Abnormality of the larynx 0.4622471798123029 1.739812647193106 0.0818919210007527 1.0 0.6562655373765833 42 P07602,Q92804,P02545,P35637,P21964,Q13510,Q15165,Q96HY6,Q96CV9,P50995,Q9UHX1 11 +Airway obstruction 0.5460631840005494 1.7374944227083955 0.0822999376197386 1.0 0.6562655373765833 16 P02545,P09601,P21964,O75844,Q96HY6,P16435 6 +Loss of speech 0.5395068619945271 1.736937446370194 0.0823982128318909 1.0 0.6562655373765833 17 P07602,P50897 2 +Skin pit 0.656061213530966 1.7369083188330654 0.0824033548319338 1.0 0.6562655373765833 9 P61978,Q07954,P16615 3 +Impaired vibration sensation in the lower limbs 0.5573371898788064 1.7341769442830115 0.0828866924537818 1.0 0.6562655373765833 14 Q9NR77 1 +Adrenal insufficiency 0.4825960082557741 1.7328129212061458 0.0831289254890941 1.0 0.6562655373765833 26 P40855,Q969G3,P33991,O75381,P56589,Q9NSE4,Q13423 7 +Retinal vascular tortuosity 0.5509393274154407 1.7297970328060688 0.0836665447781224 1.0 0.6562655373765833 15 P21964,P00846 2 +Abnormal lower motor neuron morphology 0.6713844203320953 1.729603452328951 0.0837011488207546 1.0 0.6562655373765833 8 Q99720,P35637 2 +Preaxial polydactyly 0.6326266964273055 1.7286627899545437 0.0838694646795601 1.0 0.6562655373765833 10 O43924,Q9UHX1,Q9H3P2 3 +Clonic seizure 0.6871545286224511 1.7275914045269156 0.0840615049308832 1.0 0.6562655373765833 7 P07602,P09471,O14936 3 +Status epilepticus 0.4509755413676116 1.7268054794051575 0.084202604103126 1.0 0.6562655373765833 46 P07602,P53701,Q9Y487,Q13510,Q01105,P42892,Q03252,Q15392 8 +Adipose tissue loss 0.6538107262472244 1.7255574068715285 0.0844270676357221 1.0 0.6562655373765833 9 O75844,P02545,Q03252 3 +Abnormal cranial nerve physiology 0.3785533643847364 1.7244409699222467 0.0846282667926305 1.0 0.6562655373765833 70 Q9NR77,P07602,P40855,P50570,Q969G3,P02545,Q15043,O75381,Q92796,P07196,Q13510,P56589,P51812,P21912,P16219,P48735,Q9UHX1 17 +Aplasia hypoplasia of the lungs 0.4799023931952241 1.719588437807697 0.0855072793544335 1.0 0.6600914040433367 28 Q7Z4L5,P02545,P25705,Q99567,P41227,O96000,P98175,O75844,Q9H3P2,Q8TAA9,O96028 11 +Visual loss 0.4384487616137849 1.7179998704503854 0.0857966389056266 1.0 0.6600914040433367 50 P07602,O75503,P50897,P00846,P00403,O14773 6 +Thoracic scoliosis 0.573110164716383 1.7167370025571516 0.0860272360266012 1.0 0.6600914040433367 13 P02545,O00459,O75844,Q9NSE4,Q9UHX1 5 +Myoclonic spasms 0.7221676300166299 1.7165916747845114 0.0860538046810179 1.0 0.6600914040433367 6 Q969G3,Q6PJG6,Q10713,P00846 4 +Hyperconvex fingernails 0.7553766096877973 1.7115081415150062 0.0869873495382513 1.0 0.6616397823745752 5 P51812,O96028 2 +Splenomegaly 0.3966820240408382 1.7106436749635985 0.087146911279313 1.0 0.6616397823745752 91 P14174,P02545,P21964,O14936,P00813,Q96HY6,P46100,P07602,P33991,Q14108,Q13510,Q6NUQ1,Q16625,Q15392,P28070,P35670,P54802,P16278,P10253,O15118,P04062 21 +Abnormal neuron morphology 0.4791298081026086 1.7056253448410623 0.0880778574158653 1.0 0.6659973537492014 26 Q92804,P35637,Q13510,Q15165,Q96CV9,P22626,Q99720 7 +Narrow nasal ridge 0.7189548389533688 1.7021927708028228 0.0887192375090564 1.0 0.6678893938392705 6 O75844,P02545 2 +Chorioretinal dysplasia 0.7528473313008699 1.700682352011679 0.0890026507863801 1.0 0.6678893938392705 5 P53701,Q8NAT1 2 +Intestinal pseudo obstruction 0.681378947409999 1.700272150263901 0.089079746395325 1.0 0.6678893938392705 7 P61978,P00403 2 +Abnormal delivery 0.5042486630868833 1.6966095031027186 0.0897705119713552 1.0 0.6702484033632932 21 P50570,P33991,P02545,P06753,Q9Y487,O75844,Q96EY7,Q01082 8 +Abnormal ureter morphology 0.5120564150622691 1.6963585535322523 0.089817997814501 1.0 0.6702484033632932 20 P02545,O14936,P09471,P23786,P41227,O75844,Q8TAA9,Q7LGA3,Q16531 9 +Incoordination 0.3728601678885295 1.68961785713374 0.0911010873786488 1.0 0.6773643568412395 67 Q9UGU0,Q9NR77,P07602,P35670,O75503,Q15067,P00846,Q13510,Q01105,O14773,Q6DKK2,P04062,O43681 13 +Redundant skin 0.4863135482102593 1.6880601549678491 0.0913996821230669 1.0 0.6773643568412395 23 P51812,Q9Y487 2 +Abnormal auditory evoked potentials 0.6626418420145057 1.686874517587535 0.0916274829162007 1.0 0.6773643568412395 8 P07602 1 +Multiple lipomas 0.6624903202575844 1.6861325285325912 0.0917702759285135 1.0 0.6773643568412395 8 Q9BUK6,P03915,P29992,Q8TAA9,P53680 5 +Phenotypic variability 0.4049894901946337 1.6859348459670087 0.0918083493482191 1.0 0.6773643568412395 103 Q9NR77,Q8TD16,Q13885,P02545,P00846,P41227,P21912,O43707,Q9NQT5,P07602,Q9H061,Q13868,Q9BVA1,Q13510,O14979,P36551,Q9Y5P6,Q8NI60,Q9UBB4,P50995,Q70HW3,P06753,P57740,Q13813,P00374,P00403,O15121,Q969G3,P03915,Q14671,P07196,Q8WWY3,Q92733,Q00577,Q9UEY8 35 +Muscle hypertrophy of the lower extremities 0.6245252887950371 1.685909526563345 0.0918132267511082 1.0 0.6773643568412395 10 Q9NR77,P50570,Q8NAT1,P02545 4 +Urinary glycosaminoglycan excretion 0.6780954974018764 1.6847114487634238 0.0920442565624388 1.0 0.6779699933207471 7 P54802,P16278,P04066 3 +Occipital encephalocele 0.7468342469012486 1.674907876917156 0.093952307910009 1.0 0.6844951797344273 5 P07942,O43505,Q10713 3 +Progressive neurologic deterioration 0.5087428078942353 1.6730376851167448 0.0943198775311 1.0 0.6844951797344273 20 P07602,P04062,P20700,P54802,P16278,P21912,Q5XKP0,Q10713,O43681 9 +Type ii lissencephaly 0.746132964015941 1.6718985243776343 0.0945443338326454 1.0 0.6844951797344273 5 P07942,Q8NAT1,O43505 3 +Flared iliac wing 0.8106305946522507 1.6717094742773602 0.0945816249965032 1.0 0.6844951797344273 4 O95831 1 +Abnormality of metacarpal epiphyses 0.810376119971312 1.6706793314751154 0.0947850334563868 1.0 0.6844951797344273 4 P51812,P16435 2 +Cardiovascular calcification 0.658573675549849 1.6669363736137996 0.0955270572538959 1.0 0.6844951797344273 8 O75844,O75431,P02545 3 +Generalized muscle weakness 0.4724739709636557 1.6653708606250246 0.0958387892177665 1.0 0.6844951797344273 29 O95831,Q92804,P35637,P10253,P21912,Q15165,Q96CV9,P50995 8 +Basal ganglia calcification 0.6738792658227218 1.6646992718480786 0.0959727683433928 1.0 0.6844951797344273 7 P03915,P29992,Q9Y3Z3,P00403 4 +Generalized hyperkeratosis 0.8084828711256049 1.6630129985529647 0.0963098335691032 1.0 0.6844951797344273 4 O75844,P21912,P02545 3 +Muscle fibrillation 0.5403601566617869 1.6627014597068792 0.0963722098824335 1.0 0.6844951797344273 15 P50570,O95831,P51114,Q16637,Q13510,Q9BQT8,Q96CV9,Q9NQT5 8 +Nephropathy 0.5144089944101152 1.6611194677627334 0.0966894553095862 1.0 0.6844951797344273 19 Q7Z4L5,Q14108,P03915,P06280,P57740,P36551,P00403,Q10713 8 +Fibrous tissue neoplasm 0.5135915525814762 1.6554808257704128 0.0978270026992975 1.0 0.6872478100054197 19 Q07954,Q15392,Q13126,Q969G3 4 +Hand polydactyly 0.4707937903640214 1.6518442799476336 0.0985662993366229 1.0 0.6872478100054197 29 Q7Z4L5,O60826,P21964,Q15067,O00459,O96028,P98175,O43924,Q9H3P2,P98172,Q10713,Q9UHX1 12 +Abnormal morphology of the musculature of the neck 0.5794600415614128 1.6514993135969858 0.0986366607967381 1.0 0.6872478100054197 12 P41227,Q99720,P35637,O75569 4 +Abnormal circulating copper concentration 0.7412840583316206 1.65107191859464 0.098723890527089 1.0 0.6872478100054197 5 P35670,Q15904,Q9Y487 3 +Meningioma 0.6704972700547248 1.6486220152570032 0.0992250956376383 1.0 0.6872478100054197 7 Q969G3,P78549,P02545 3 +Abnormal circulating fatty acid concentration 0.5124407785601539 1.6475387003982764 0.0994473683876411 1.0 0.6872478100054197 19 O43772,O75381,P23786,O75431,P56589,P16219 6 +Agenesis of corpus callosum 0.3815758743645342 1.6465782059368594 0.0996447731308169 1.0 0.6872478100054197 80 P78318,P46100,P98172,Q7LGA3,Q9UHX1,Q10713,Q9BVA1,Q9Y5P6,Q14004,Q15392,O96028,Q8NAT1,P00403,Q9H3P2,P53701,Q969G3,P61978,O15344,P03915,P23786,O43505,Q86XL3 22 +Abnormality of the parathyroid gland 0.4888751243595738 1.6437536039077756 0.1002271085167887 1.0 0.6872478100054197 22 P35670,P03915,P21964,P00403,Q08J23 5 +Upper airway obstruction 0.7388510157846419 1.6406094290257551 0.1008785164397934 1.0 0.6872478100054197 5 O75844,Q96HY6,P02545 3 +Hypolipoproteinemia 0.6525007929588792 1.637109481506936 0.1016075958114339 1.0 0.6872478100054197 8 P37268,Q15800 2 +Centrally nucleated skeletal muscle fibers 0.6521730934892187 1.635497855463181 0.1019447238836885 1.0 0.6885050194637248 8 P50570,P51114,P06753,Q13586,P22626,Q9BPX6 6 +Abnormal renal cortex morphology 0.4326254435487826 1.631698324580663 0.1027430531903657 1.0 0.6886218654440682 49 Q8N1F7,Q14C86,P02545,Q14108,P03915,O75431,Q8NFH4,P00846,P00813,P21912,P00403,Q03252 12 +Abnormal brainstem mri signal intensity 0.4871347550141876 1.630869311230175 0.1029178984770793 1.0 0.6886218654440682 22 O43676,Q96CU9,O95831 3 +Ventricular hypertrophy 0.465718442545606 1.630843937769297 0.1029232536648243 1.0 0.6886218654440682 32 P02545,O43772,P10253,P03915,P23786,O75431,O75844,P21912,P00403,Q15233 10 +Postaxial hand polydactyly 0.6137573178406637 1.62883697448453 0.1033475351114234 1.0 0.6886218654440682 10 Q7Z4L5,O43924,O00459,Q10713 4 +Increased csf lactate 0.4198306678187863 1.628782796596948 0.1033590078157007 1.0 0.6886218654440682 53 O95831,P39210,P00846,O43676,Q96CU9,O96000,Q8NI60,P00403 8 +Neoplasm of the oral cavity 0.5902897102218043 1.620576828731733 0.1051084249717082 1.0 0.6902558477970048 11 O43924,P02545 2 +Abnormal upper motor neuron morphology 0.6490198720975204 1.6199793075996378 0.1052367219620213 1.0 0.6902558477970048 8 Q99720 1 +Abnormal pupillary light reflex 0.9834915783854472 1.6124042571022266 0.1068739991005633 1.0 0.6969777133320408 3 Q9NR77 1 +Slow pupillary light response 0.9834915783854472 1.6124042571022266 0.1068739991005633 1.0 0.6969777133320408 3 Q9NR77 1 +Asthma 0.4999897982862483 1.6112310559842322 0.107129371265134 1.0 0.6971261463688933 20 P00813,P21964 2 +Blindness 0.3776890703865467 1.609932397164665 0.1074126154427403 1.0 0.6971261463688933 79 P07602,P53701,P16278,P06865,P50897,P00846,O43676,Q96CU9,O96000 9 +Nemaline bodies 0.7950427655027975 1.608479918865528 0.1077301107715604 1.0 0.6971261463688933 4 O43676,P07196 2 +Short upper lip 0.7949678616065302 1.6081754749990067 0.1077967528633576 1.0 0.6971261463688933 4 P46100 1 +Sparse lateral eyebrow 0.6980177283321871 1.607938366462497 0.1078486780060172 1.0 0.6971261463688933 6 P61978,Q08J23 2 +Vascular skin abnormality 0.4075787875924421 1.6071590124923822 0.1080194907045524 1.0 0.6971261463688933 114 P21964,P22830,P00846,P46100,Q8IZA0,Q08J23,Q14108,Q9Y487,Q16625,Q13126,P51812,P00403,Q9NWM8,P35670,P53701,P16278,Q07954,P03915,P10619 19 +Titubation 0.6299032394203182 1.604264595078544 0.1086557416990334 1.0 0.6971261463688933 9 P20700,P35637,Q5JRX3,Q6PJG6,Q01082,Q99720 6 +Broad palm 0.7301994927792744 1.6033418216910915 0.1088592079248276 1.0 0.6971261463688933 5 O95831 1 +Upper limb amyotrophy 0.5248323880534825 1.599941090939353 0.1096116524993637 1.0 0.7007402431650831 16 Q9NR77,P07196 2 +Ovarian cyst 0.5532375947222222 1.5976939641752026 0.1101111027111445 1.0 0.7011317338608649 13 P02545,P21912,P20585,Q03252,P78549 5 +Abnormality of circulating adrenocorticotropin level 0.5853161814792128 1.5928668249771891 0.1111900700028307 1.0 0.7066264064246137 11 Q969G3,Q13423,P46100 3 +Intracellular accumulation of autofluorescent lipopigment storage material 0.97098141506358 1.5916188027430476 0.1114703826346283 1.0 0.7066264064246137 2 O75503 1 +Abnormal gastrointestinal motility 0.4735512842315679 1.5912213232320231 0.111559775702374 1.0 0.7066264064246137 23 P35637,P61978,P03915,P06280,P36551,Q9NSE4,P00403,Q01844 8 +Abnormal midbrain morphology 0.6942549916509452 1.590925515468009 0.1116263395190997 1.0 0.7066264064246137 6 O43924,P04062 2 +Chronic pulmonary obstruction 0.6581817179794172 1.5898959078605672 0.1118582702246344 1.0 0.7066264064246137 7 P21964 1 +Abnormal corpus striatum morphology 0.5229399459625037 1.5876080237712535 0.1123750026904246 1.0 0.7066264064246137 16 O95831,P00846 2 +Short nail 0.7898300127141794 1.5872797061299655 0.1124493093961984 1.0 0.7066264064246137 4 Q9Y487,P02545 2 +Recurrent fever 0.5168325864894929 1.5870105792000553 0.1125102486133167 1.0 0.7066264064246137 17 Q9NR77,Q13510,P28070 3 +Hypotension 0.4636003746822216 1.585723081015738 0.1128021409763513 1.0 0.7066264064246137 27 P49366,Q13423,P07602,O43772 4 +Sensory ataxia 0.7893992177666525 1.5855264879450317 0.1128467636288061 1.0 0.7066264064246137 4 Q9NR77 1 +Abnormal circulating acetylcarnitine concentration 0.6572061386571444 1.5852321154842832 0.1129136062371387 1.0 0.7066264064246137 7 P23786,O43772 2 +Stuttering 0.7890314227235797 1.5840295220800258 0.1131870010623341 1.0 0.7066264064246137 4 P00403 1 +Wormian bones 0.5031785095262309 1.5834408492238967 0.1133210186050017 1.0 0.7066264064246137 19 O95831,Q32P28,P02545,Q9Y487,O75844 5 +Tongue fasciculations 0.5825489354754229 1.5774229678487603 0.1146982340469477 1.0 0.7075198340564773 11 O95831,P51114,Q13510,Q9BQT8,Q96CV9,Q9NQT5 6 +Prominent sternum 0.9673948483860462 1.5774224554235228 0.1146983518756936 1.0 0.7075198340564773 2 O95831 1 +Generalized clonic seizure 0.6907778846452115 1.575185122420845 0.1152137202584249 1.0 0.7087200738058786 6 P07602,O14936 2 +Abnormal nephron morphology 0.3964212289957962 1.5707297733742778 0.1162454303488333 1.0 0.7091778445806916 58 Q8N1F7,Q14C86,P02545,Q14108,P03915,P23786,O75431,Q8NFH4,P00846,P00813,P21912,P00403,Q03252 13 +Neoplasm of fatty tissue 0.5812098662777746 1.569943102979188 0.1164283486789083 1.0 0.7091778445806916 11 Q9BUK6,P03915,P21912,P29992,Q8TAA9,P53680 6 +Hand muscle weakness 0.5810325364659906 1.5689522426778906 0.1166590673894698 1.0 0.7091778445806916 11 Q9NR77 1 +Abnormality of the 5th toe 0.6892176406498955 1.5681162876694483 0.1168539960432077 1.0 0.7091778445806916 6 Q7Z4L5,O43924,Q10713 3 +Postaxial foot polydactyly 0.6892176406498955 1.5681162876694483 0.1168539960432077 1.0 0.7091778445806916 6 Q7Z4L5,O43924,Q10713 3 +Cranial asymmetry 0.7846479218212761 1.56617840632565 0.1173068565001869 1.0 0.7091778445806916 4 P40855 1 +Distal amyotrophy 0.4066185633647645 1.5625161072509208 0.118166454362462 1.0 0.7091778445806916 55 Q9NR77,P50570,Q8TD16,P02545,P35637,P07196,P39210,Q13510,P21912,Q9BQT8,Q96BR5,Q99720 12 +Hypoplasia of the iris 0.7836940953687789 1.5622917459897658 0.1182192755907682 1.0 0.7091778445806916 4 Q7LGA3,O96028 2 +Distal upper limb amyotrophy 0.5473432328005339 1.5621687554872108 0.1182482390238894 1.0 0.7091778445806916 13 Q9NR77,P07196 2 +Abnormality of peripheral nerves 0.4325715643521277 1.5536873832818938 0.1202590040174926 1.0 0.7183976198000349 46 Q9NR77,P07602,P50570,O95831,P02545,P07196,P39210,O15121,Q99720 9 +Sea blue histiocytosis 0.9611998695793932 1.5528941758784205 0.120448418433456 1.0 0.718586108399858 2 P16278 1 +Hypokinesia 0.5779296391030951 1.551602320882446 0.1207574074956658 1.0 0.7190020997325806 11 O95831,Q99567,P04062 3 +Goiter 0.7181512574496121 1.5512822762650165 0.1208340523496098 1.0 0.7190020997325806 5 P21912,P48735 2 +Centrocecal scotoma 0.7792170562192641 1.5440377719548883 0.1225791823969504 1.0 0.7265370289985915 4 P00846 1 +Arthralgia 0.4517381729644792 1.541832279545063 0.1231143557711902 1.0 0.7273674872787671 35 P28070,P35670,P14174,P02545,Q15800,Q13510,Q96HY6,O15460 8 +Duplication involving bones of the feet 0.5206864049851966 1.5369750927493404 0.1242994088443749 1.0 0.7273674872787671 15 Q7Z4L5,P21964,O43924,Q10713,O96028 5 +Abnormal mitochondria in muscle tissue 0.4662840006522861 1.535776940735963 0.1245930970725386 1.0 0.7273674872787671 23 O43676,Q96CU9,O96000,P00403 4 +Muscle spasm 0.3969011737214115 1.5350735028379647 0.1247657741017254 1.0 0.7273674872787671 57 Q9NR77,Q92804,P35637,Q9H6K4,P06280,P07196,P23786,P00846,Q15165,P53985,Q96CV9,P50995,P04062,O00592 14 +Distal sensory impairment 0.4433289402527459 1.5347595518394206 0.1248429017021071 1.0 0.7273674872787671 40 Q9NR77,P50570,O95831,P20700,P54802,P02545,P07196,P39210,Q9NSE4,Q96BR5 10 +Cardiac conduction abnormality 0.454011255276747 1.5338899105151695 0.1250567385551562 1.0 0.7273674872787671 32 P02545,O43772,Q07954,P03915,P23786,P00846,P50402,P00403,Q14BN4 9 +Mitochondrial respiratory chain defects 0.7138332928973933 1.5325819075071736 0.1253789021255049 1.0 0.7273674872787671 5 Q4J6C6,P03915,P00846 3 +Axonal degeneration 0.6803792613039285 1.5280071822540189 0.1265107547300834 1.0 0.7273674872787671 6 Q6DKK2,Q9BQT8 2 +Glomerulopathy 0.614909707219328 1.527573492530519 0.1266184673071344 1.0 0.7273674872787671 9 Q14108,P02545,Q03252 3 +Periauricular skin pits 0.6302035838613117 1.5269764949403932 0.1267668563199919 1.0 0.7273674872787671 8 P61978,Q07954 2 +Abnormal csf metabolite level 0.3885042665735351 1.525662216175597 0.1270940089046424 1.0 0.7273674872787671 59 O95831,P39210,P00846,O43676,Q96CU9,O96000,Q8NI60,P00403 8 +Mucosal telangiectasiae 0.6143952123010894 1.5249339585690151 0.1272755707587807 1.0 0.7273674872787671 9 P10619,P21912,P06280,Q8IZA0 4 +Decreased circulating cortisol level 0.6292315448431323 1.5221542948559177 0.1279704242035773 1.0 0.7273674872787671 8 Q969G3,Q13423 2 +Shoulder girdle muscle weakness 0.5722032180775383 1.5195247655192154 0.1286304591198439 1.0 0.7273674872787671 11 O14979,P07602,Q8TD16 3 +Vertebral hypoplasia 0.5932471353817588 1.5193960125347168 0.1286628450615667 1.0 0.7273674872787671 10 Q8TAA9,Q6NUQ1,P16278,Q96HY6 4 +Fever 0.3749119177807211 1.5193661655205806 0.1286703535487596 1.0 0.7273674872787671 84 Q9NR77,P07602,P28070,P14174,Q8N1F7,Q14C86,P61978,P03915,P10253,P23786,Q8NFH4,O14936,P00846,P00813,Q13510,P00403,O15460 17 +Abnormality of extrapyramidal motor function 0.3599264689742102 1.5169840322975832 0.1292707155554751 1.0 0.7273674872787671 68 Q15043,P35610,P98175,P07686,Q9BPX6,O00592,P07602,P35637,P17480,Q9UBB4,O75569,Q9Y3Z3,P06753,Q9H6K4,P16278,O14949,P06865,O96008,Q00577,Q9H9P8,P61457,Q99720,Q6DKK2,P04062 24 +Lower limb pain 0.6775310563649432 1.515058718358406 0.1297575347358972 1.0 0.7279032182839539 6 P00846 1 +Blurred vision 0.7096456009976518 1.5144253526642022 0.1299179931686738 1.0 0.7279032182839539 5 P03915,P04439,P00846 3 +Lower limb amyotrophy 0.4920679000168516 1.5061663138684778 0.1320244846287188 1.0 0.7337696312087774 19 Q9NR77,P07196,Q8TD16,P02545 4 +Neuronal loss in central nervous system 0.5543369488540534 1.5059237312161171 0.1320867537297583 1.0 0.7337696312087774 12 O15118,P07602,P35637 3 +2 3 toe syndactyly 0.4535019779882046 1.5029028358671004 0.1328641016340792 1.0 0.7355695371057906 26 P51812,P37268,O43924,Q9UHX1 4 +Neoplasm of the male external genitalia 0.6249140982683965 1.5007159031893842 0.1334290579683026 1.0 0.7370983881938271 8 Q13423 1 +Pedal edema 0.639420861599012 1.4999233997228094 0.1336342458451351 1.0 0.7373370752570366 7 Q14108 1 +Anterior rib cupping 0.7058885085041877 1.4981193007833122 0.134102257339324 1.0 0.7389247429938699 5 P00813 1 +Abnormal larynx morphology 0.4528316874385535 1.4975636666610224 0.1342466525606174 1.0 0.7389247429938699 26 P07602,P02545,P21964,Q13510,Q96HY6 5 +Abnormality of adrenal physiology 0.4494368906582042 1.495844566399681 0.1346941646366557 1.0 0.7394692657517448 32 P40855,Q969G3,P33991,O75381,P56589,Q9NSE4,Q13423,Q9H4A3 8 +Male reproductive system neoplasm 0.5524054470625975 1.4946677174138725 0.1350011834565874 1.0 0.7394692657517448 12 Q13423 1 +Arteriosclerosis 0.5360473947210159 1.493835277296012 0.1352186785308156 1.0 0.7394692657517448 13 O15118,P16278,P02545,Q13510 4 +Chordee 0.6727097797072312 1.4931157181016002 0.1354068988029619 1.0 0.7394692657517448 6 P53701 1 +Abnormality of the achilles tendon 0.5358561674366998 1.4926757293620887 0.1355220894977815 1.0 0.7394692657517448 13 Q92734,Q8TD16,Q9BTV4,P02545,Q15041,P50402,Q08J23,Q15149 8 +Heterogeneous 0.4397642917453335 1.4879076122065056 0.1367752599132696 1.0 0.7439629220345392 39 Q9NR77,P02545,P03915,P21964,P07196,P00846,O75844,P11717,P46100 9 +Gonadal neoplasm 0.4751253486714961 1.485421521177238 0.1374321981987414 1.0 0.7465290766117791 21 Q01844,Q13423,P02545,P48735 4 +Hypoketotic hypoglycemia 0.6356945703397235 1.4819847832098865 0.1383443439131202 1.0 0.7477822201455732 7 O43772 1 +Sensory neuropathy 0.4485272401973152 1.4816396434409318 0.1384362047140517 1.0 0.7477822201455732 31 O95831,Q8IV08,P03915,Q15067,P00846,Q9NSE4,P00403 7 +Generalized myoclonic seizure 0.4373539547390294 1.4814591106721635 0.1384842731947975 1.0 0.7477822201455732 40 P07602,P16278,P03915,Q01105,Q13510,P00846,Q96N66,P04062 8 +Abnormal diaphysis morphology 0.3765758485305491 1.479986972578121 0.1388767233361756 1.0 0.7479129784492896 61 Q9NR77,Q32P28,Q13126,P16278,Q9Y487,O75431,P51812,Q96HY6,P46100,Q7LGA3 10 +Hemiparesis 0.5114731545632851 1.477710523797558 0.1394852763610703 1.0 0.7496304344694122 15 P03915,Q9BVA1,P00403 3 +Talipes equinovarus 0.3584527939020677 1.4749092524047251 0.1402369424931955 1.0 0.7517953945038628 70 Q9NR77,Q8TD16,P21964,Q96A33,P98175,P46100,P32929,Q9Y487,Q6NUQ1,Q8NI60,Q15392,O96028,P06753,Q8NBU5,Q9H3P2,Q8TAA9,Q9NWM8,P16435,P61978 19 +Oculomotor nerve palsy 0.7002095658343752 1.4734440780955158 0.1406313323202326 1.0 0.7522371618351338 5 Q969G3,Q15149 2 +Calcinosis 0.6998027493108898 1.4716751875339564 0.1411086110652222 1.0 0.7532091703423224 5 O75844,P02545 2 +Posterior embryotoxon 0.4995393642252799 1.4715442657306392 0.1411439855672234 1.0 0.7532091703423224 17 P53701,O75381,P21964,P56589,Q7LGA3 5 +Abnormal circulating fatty acid anion concentration 0.5320791498511409 1.4697552480664222 0.1416280535736276 1.0 0.7540244442890678 13 P23786,O43772 2 +Anhidrosis 0.6670537103953308 1.467335468537646 0.1422848196494013 1.0 0.7566360970141061 6 P20700,Q9H4A3 2 +Head titubation 0.6664247312296552 1.464466156987085 0.1430666234753825 1.0 0.7595744717107404 6 Q99720,P20700,P35637 3 +Abnormal placenta morphology 0.6316959202168562 1.4627115784680138 0.14354631658956 1.0 0.7595744717107404 7 P16278,P02545 2 +Difficulty walking 0.3630283372355339 1.4621822897869574 0.1436912634415128 1.0 0.7595744717107404 76 Q9NR77,P07602,P50570,P35670,Q969G3,Q96F07,P35637,O43681,Q15067,P00846,Q13510,O14773,Q99720,Q9BPX6 14 +Hip pain 0.697414832259518 1.4612889379705978 0.1439361643460115 1.0 0.7595744717107404 5 O75844,P02545 2 +Postaxial polydactyly 0.4914130176136927 1.4572265857875828 0.1450538441996838 1.0 0.7595744717107404 18 Q7Z4L5,P61978,O00459,P98175,O43924,Q10713 6 +Preaxial hand polydactyly 0.6644018561863322 1.4552348816629663 0.1456042472083591 1.0 0.7600808868032695 6 Q9UHX1,Q9H3P2 2 +Primary adrenal insufficiency 0.5074478881391021 1.4517481591030614 0.1465716431743571 1.0 0.7625075654053413 15 P40855,Q969G3,O75381,P56589,Q13423 5 +Increased circulating prolactin concentration 0.6285683439706813 1.447620535784197 0.1477232046766987 1.0 0.7627863323479636 7 Q969G3,Q9BUK6 2 +Ascites 0.4765694470062452 1.4445301311031469 0.1485899103765553 1.0 0.765137185558914 20 O15118,Q14108,Q01844,Q13510 4 +Abnormal left ventricle morphology 0.4458072597539913 1.4407784884099846 0.1496472726105839 1.0 0.7653976504736807 25 P10253,P06280,P03915,O75431,P21912,P00403,Q15233 7 +Mutism 0.5270540999536237 1.4392106196494676 0.1500908574587005 1.0 0.7653976504736807 13 P53701,P35637,Q13510 3 +Rigidity 0.4043941088194104 1.438564923464262 0.1502738304856024 1.0 0.7653976504736807 52 P07602,P16278,Q96F07,O43681,Q9H6K4,O14936,P00846,Q96CU9,Q15392,P04062,Q9BPX6 11 +Slender long bone 0.5426136716519205 1.4374790175869574 0.1505819306482652 1.0 0.7653976504736807 12 P37268,Q9Y487 2 +Abnormality of t cell physiology 0.4999810586325471 1.437150280525494 0.150675296921328 1.0 0.7653976504736807 16 P21964 1 +Abnormality of the musculature of the lower limbs 0.4437598396397501 1.436849183725751 0.1507608516560401 1.0 0.7653976504736807 30 Q9NR77,P50570,P02545,P07196,P00846,O14979,P50402,Q8NAT1,O00592 9 +Diffuse mesangial sclerosis 0.5051346171748353 1.4368098941662095 0.1507720182641749 1.0 0.7653976504736807 15 Q8N1F7,Q14C86,Q8NFH4,P57740,P00813,O43707 6 +Pericarditis 0.6917288659035009 1.4365360452344471 0.1508498672328153 1.0 0.7653976504736807 5 P14174 1 +Cutaneous photosensitivity 0.4532698753680386 1.4359993584335184 0.1510025238230306 1.0 0.7653976504736807 23 Q08J23,P22830,P37268,Q14108 4 +Abnormal nerve conduction velocity 0.4285665117273902 1.4350009358300069 0.151286830923125 1.0 0.7653976504736807 42 Q9NR77,P07602,O95831,P50570,P02545,P07196,O15121,Q99720 8 +Nephrotic syndrome 0.4524466795875319 1.4296687807864477 0.1528121045170043 1.0 0.7665533666647025 23 Q8N1F7,O95721,Q14108,P06280,P57740,P00813,Q12769,Q03252,Q07021 9 +Aplasia hypoplasia of the femur 0.5412740921116279 1.429639594466752 0.1528204853993031 1.0 0.7665533666647025 12 O95831,Q96HY6,Q9UHX1 3 +Macrogyria 0.6247782836088249 1.4293143605565966 0.1529139003201276 1.0 0.7665533666647025 7 Q15392,Q8NAT1,O14936 3 +Abnormality of krebs cycle metabolism 0.6586048210649994 1.4287541276963178 0.1530749143888872 1.0 0.7665533666647025 6 P00846 1 +Neoplasm of the thyroid gland 0.4594284094610303 1.4242166809973955 0.1543837575755029 1.0 0.7722580928392191 22 P21912,Q969G3,P02545,P42892 4 +Neurofibromas 0.623511899302776 1.4231932655074404 0.1546801373336606 1.0 0.7728913119021108 7 Q07954,Q969G3,P21912 3 +Increased muscle lipid content 0.6089412709449581 1.421135887027784 0.1552772588605921 1.0 0.7741753366192942 8 P23786,Q8NI60,P06753 3 +Spondyloepimetaphyseal dysplasia 0.6863201595952171 1.4129633934125827 0.1576664877883633 1.0 0.7783651263494049 5 O95831,Q96HY6 2 +Recurrent aspiration pneumonia 0.6551043703419935 1.4127460771076013 0.1577303982659681 1.0 0.7783651263494049 6 P04062,Q13510 2 +Limb pain 0.5728333349375735 1.4096180673105878 0.1586524892176655 1.0 0.7797668411173134 10 O75477,P36551,O75569,P00846 4 +Abnormal peripheral nervous system physiology 0.4071667965365057 1.408533886528466 0.1589730401190829 1.0 0.7797668411173134 50 Q9NR77,P07602,P50570,O95831,P02545,P07196,P39210,O15121,Q99720 9 +Abnormal vascular physiology 0.4194997555972601 1.408086629359251 0.1591054197141799 1.0 0.7797668411173134 45 P02545,P25705,Q14108,P03915,O75844,O96000,P00403,Q8IZA0,O15460,Q9NWM8 10 +Skeletal muscle hypertrophy 0.4215896139673588 1.4075312153668214 0.1592699277546119 1.0 0.7797668411173134 44 Q9NR77,P50570,P16278,P02545,P61978,P10253,Q96A33,P21912,Q9Y5P6,Q8NAT1,P46100,Q7LGA3,Q10713 13 +Skin ulcer 0.4409311130645744 1.4061630403931045 0.1596757163398188 1.0 0.7797668411173134 28 Q14739,P02545,Q15149,Q03519,P39210,P48735,Q9H4A3,O95394,Q8IZA0,O15460,O75874,P04062 12 +Low plasma citrulline 0.9240299967394928 1.4056610636601083 0.1598247941042296 1.0 0.7797668411173134 2 P00846 1 +Multiple glomerular cysts 0.9240299967394928 1.4056610636601083 0.1598247941042296 1.0 0.7797668411173134 2 P00846 1 +Leber optic atrophy 0.9240299967394928 1.4056610636601083 0.1598247941042296 1.0 0.7797668411173134 2 P00846 1 +Retinal arterial tortuosity 0.9240299967394928 1.4056610636601083 0.1598247941042296 1.0 0.7797668411173134 2 P00846 1 +Vascular tortuosity 0.9240299967394928 1.4056610636601083 0.1598247941042296 1.0 0.7797668411173134 2 P00846 1 +Prenatal maternal abnormality 0.5199927708278658 1.3961971379950813 0.1626551383306891 1.0 0.7868291069939393 13 P16435,P02545,O43772,P49366,Q8TAA9,Q01082 6 +Decreased plasma carnitine 0.5500299446971242 1.3946658892222252 0.163116615719709 1.0 0.7873879477795499 11 O43772 1 +Cupped ribs 0.6507370669413265 1.3927558443317811 0.1636936350827897 1.0 0.7893362573059948 6 P00813 1 +Raynaud phenomenon 0.6500012843151968 1.3893861037134458 0.1647153736315627 1.0 0.790911794062103 6 O75844,Q14739,P02545 3 +Prominent eyelashes 0.6019694292162777 1.3862803606691871 0.1656613113695635 1.0 0.7921116484813584 8 O14497,Q969G3,P20700,Q92785 4 +Abnormality of retinal pigmentation 0.3492983489477875 1.3837994619341307 0.1664198678592896 1.0 0.793238993188991 68 Q7Z4L5,P53701,P02545,O75381,P03915,Q6P4Q7,Q15067,P00846,P56589,Q96CU9,P21912,P51812,P00403 13 +Muscle fiber atrophy 0.4739597297832618 1.379434924030791 0.1677606976302561 1.0 0.7956191000754963 19 P35637,P02545,P61978,P23786,P50402,P22626,Q99720 7 +Hemolytic anemia 0.4335833183070922 1.377837600825336 0.1682534339988333 1.0 0.7969715208768878 34 P00813,P09601,P22830 3 +Proximal tubulopathy 0.437569967395079 1.375272148118618 0.1690470878951959 1.0 0.7976135836921552 25 O43676,Q96CU9,O96000,P00403 4 +Multifactorial inheritance 0.5463951285427725 1.3741098030745869 0.1694075965237389 1.0 0.7976135836921552 11 P10321,P42892 2 +Dolichocephaly 0.4372577440488872 1.3727851636999422 0.1698191443545567 1.0 0.7983672952974733 25 P40855,Q9H3P2,P61978,Q4J6C6,O75381,P56589,P46100,Q01082,Q03164,O96028 10 +Punctate cataract 0.7358690042668542 1.3665333299852576 0.171771626899319 1.0 0.8032904591146084 4 P08670 1 +Hallucinations 0.4240801885961411 1.362519119296988 0.173034114492018 1.0 0.8040085647066093 40 P07602,O75503,P21964,P50897,Q6DKK2 5 +Broad nasal tip 0.3937263620650482 1.3597121834101698 0.1739210211600583 1.0 0.8040085647066093 53 O95831,Q969G3,P16278,P61978,Q9Y487,Q92796,O14936,P51812,Q00577,O43924,Q7LGA3,Q9UHX1 12 +Gowers sign 0.4931776008585427 1.359403991588619 0.1740186069551204 1.0 0.8040085647066093 15 Q8TD16,P06753,Q9BUK6,P07196,Q13510,Q8NAT1 6 +Exercise induced muscle cramps 0.6431882744902234 1.3581596763282875 0.1744130226166498 1.0 0.8040085647066093 6 P53985 1 +Aplasia hypoplasia involving the pelvis 0.5434108026444977 1.3572161644528729 0.174712536084802 1.0 0.8040085647066093 11 O95831,O75431,Q96HY6,Q9H3P2 4 +Corneal dystrophy 0.7331592923270365 1.3554031192744491 0.1752891563725032 1.0 0.8040085647066093 4 Q13868 1 +Tongue nodules 0.9106618845777724 1.352757031044503 0.1761332641241952 1.0 0.8040085647066093 2 O43924 1 +Alveolar ridge overgrowth 0.9106618845777712 1.352757031044498 0.1761332641241968 1.0 0.8040085647066093 2 Q15392 1 +Central hypoventilation 0.6086044102009174 1.350985006388005 0.1767002357022464 1.0 0.8040085647066093 7 O43819,O75306,Q8N183,P06753 4 +Hyperlipoproteinemia 0.5806403027452889 1.3507519077890364 0.1767749183214666 1.0 0.8040085647066093 9 Q8N511,P02545 2 +Increased ldl cholesterol concentration 0.5806403027452889 1.3507519077890364 0.1767749183214666 1.0 0.8040085647066093 9 Q8N511,P02545 2 +Abnormal talus morphology 0.4812147318732092 1.3483192208335264 0.1775557326598578 1.0 0.8040085647066093 17 P02545,Q99567,Q9UPT5,O75844,P98175,Q9UHX1 6 +Ventricular arrhythmia 0.4279528584253075 1.3477944236156167 0.1777245119684363 1.0 0.8040085647066093 36 P02545,O43772,P10253,P03915,P23786,P00846,P41227,P21912,P36551,P50402,P00403,P42892,Q8NFF5,Q14BN4 14 +Subcutaneous hemorrhage 0.4190027644646751 1.347492775045845 0.1778215787953516 1.0 0.8040085647066093 42 Q13126,Q14108,P21964,P46100,Q16625,Q9NWM8 6 +Bone pain 0.4628541870132492 1.3461533563076329 0.1782530641392448 1.0 0.8040085647066093 20 P35670,P07602,P48735,Q14108 4 +Supraventricular arrhythmia 0.4859474235660483 1.3445278750131957 0.1787777487195143 1.0 0.8040085647066093 16 P02545,P00846,P41227,P50402,Q14BN4 5 +Schizophrenia 0.462523706193635 1.3437772977841225 0.17902041280623 1.0 0.8040085647066093 20 P07602,P21964,P16615,P04062,O43681 5 +Neoplasm of the small intestine 0.6396632218029527 1.341987078531626 0.17960018534249 1.0 0.8040085647066093 6 P78549,P02545 2 +Abnormality of femur morphology 0.3484042732034982 1.341896275715707 0.1796296294914323 1.0 0.8040085647066093 65 P07602,O95831,Q32P28,P04062,P16278,P02545,Q9Y487,O75431,O75844,P51812,Q6NUQ1,Q96HY6,P46100,Q7LGA3,Q9UHX1 15 +Diaphragmatic weakness 0.6697245667716808 1.3404952646631318 0.1800843828036922 1.0 0.8040085647066093 5 Q9NR77 1 +Ketotic hypoglycemia 0.9086757990867518 1.3375907471780035 0.1810298823400109 1.0 0.8040085647066093 3 Q13423,P53985 2 +Dysdiadochokinesis 0.5102514199902539 1.336701361076396 0.1813201374829851 1.0 0.8040085647066093 13 P20700,P41440,Q9BUK6,O75503,O75027,Q6DKK2 6 +Underdeveloped nasal alae 0.4677755266905234 1.3359662212465857 0.181560314300111 1.0 0.8040085647066093 19 Q5KU26,P55795,P61978,O75431,P41227,Q00577,Q08J23,Q16531 8 +Macrovesicular hepatic steatosis 0.604699217921227 1.332026987975523 0.1828513203317807 1.0 0.8040085647066093 7 O75431,P23786,P39210 3 +Epiphora 0.7270343371879423 1.3302358178922302 0.1834405863394967 1.0 0.8040085647066093 4 Q07954 1 +Neurodegeneration 0.4317471892117493 1.3297047767668615 0.183615560380824 1.0 0.8040085647066093 27 Q92804,Q9Y3Z3,P35637,Q96I59,P17480,P43243,P09651,Q15165,Q6DKK2,Q96CV9,P50995,Q14203,Q5JTZ9,Q01082 14 +Type 1 muscle fiber atrophy 0.6041036153325082 1.3291342156035355 0.1838036937144633 1.0 0.8040085647066093 7 P61978,P50402,P02545 3 +Abnormal lung development 0.418650718785412 1.3283428311977152 0.1840648762309356 1.0 0.8040085647066093 41 Q7Z4L5,P02545,P25705,P21964,Q99567,P41227,O96000,P98175,O75844,Q9H3P2,Q8TAA9,Q9UHX1,O96028 13 +Peripheral hypermyelination 0.9059217480913712 1.3274655774379975 0.1843547194590686 1.0 0.8040085647066093 3 Q9NR77 1 +Abnormal circulating sulfur amino acid concentration 0.5899736682493313 1.326159978455181 0.1847867126526927 1.0 0.8040085647066093 8 P41440 1 +Abnormality of the shoulder girdle musculature 0.4306673402004433 1.3253115518535532 0.1850678391082341 1.0 0.8040085647066093 29 P07602,Q8TD16,P02545,Q9Y487,P07196,O14979,P50402 7 +Cyanosis 0.4721399661085689 1.3248208205899088 0.1852305874528017 1.0 0.8040085647066093 18 P51812,P98175,P02545,O43772 4 +Pulmonary hypoplasia 0.4462053345709639 1.3247342054533546 0.1852593238784787 1.0 0.8040085647066093 22 P02545,P25705,Q99567,P41227,O96000,P98175,O75844,Q8TAA9 8 +Metatarsus valgus 0.7252273177331107 1.3228088261034838 0.1858989613356965 1.0 0.8040085647066093 4 Q8NAT1,O43505 2 +Gastrointestinal obstruction 0.5230508995260563 1.3226669338081396 0.1859461644175877 1.0 0.8040085647066093 12 P21912,Q01844,P42892 3 +Visual acuity test abnormality 0.6655102843848619 1.3220648003468691 0.186146573769161 1.0 0.8040085647066093 5 P25054,Q969G3,Q12824 3 +Frontotemporal dementia 0.588761967333452 1.320077826781017 0.186809034976445 1.0 0.8040085647066093 8 O96008,Q14203,P22626,P35637 4 +Aplasia hypoplasia involving the vertebral column 0.4870148481624126 1.3193971188335114 0.1870363844850771 1.0 0.8040085647066093 15 O95831,P16278,Q96HY6 3 +Hyporeflexia of upper limbs 0.9021845451581458 1.319245516355208 0.1870870459772733 1.0 0.8040085647066093 2 Q9NR77 1 +Abnormality of the musculature of the upper arm 0.6019123704358808 1.3184885864273563 0.1873401433276846 1.0 0.8040085647066093 7 O14979,P02545 2 +Proximal upper limb amyotrophy 0.6019123704358808 1.3184885864273563 0.1873401433276846 1.0 0.8040085647066093 7 O14979,P02545 2 +Dysostosis multiplex 0.5744043317340972 1.318385855577987 0.1873745132815989 1.0 0.8040085647066093 9 P54802,P16278 2 +Widely spaced incisors 0.6645875133193551 1.3180279782089577 0.1874942822108081 1.0 0.8040085647066093 5 P46100 1 +Ureteral duplication 0.6341214623571884 1.3165421747285673 0.1879921326444147 1.0 0.8040085647066093 6 O75844,P23786,P02545 3 +Orthostatic hypotension due to autonomic dysfunction 0.5738143379898378 1.315321193077899 0.1884019784644723 1.0 0.8040085647066093 9 P07602,P04062,O43681 3 +Achilles tendon contracture 0.5359898405512878 1.315148948851941 0.1884598485382431 1.0 0.8040085647066093 11 P50402,Q08J23,P02545 3 +Abnormal sweat gland morphology 0.9008803390935758 1.3140932040038578 0.1888148408768377 1.0 0.8040085647066093 2 P02545 1 +Prominent umbilicus 0.9008803390935758 1.3140932040038578 0.1888148408768377 1.0 0.8040085647066093 2 P02545 1 +Patchy alopecia 0.9008803390935758 1.3140932040038578 0.1888148408768377 1.0 0.8040085647066093 2 P02545 1 +Severe failure to thrive 0.9008803390935758 1.3140932040038578 0.1888148408768377 1.0 0.8040085647066093 2 P02545 1 +Stiff skin 0.9008803390935758 1.3140932040038578 0.1888148408768377 1.0 0.8040085647066093 2 P02545 1 +Aplasia hypoplasia of the colon 0.9008803390935758 1.3140932040038578 0.1888148408768377 1.0 0.8040085647066093 2 P02545 1 +Epidermal hyperkeratosis 0.9008803390935758 1.3140932040038578 0.1888148408768377 1.0 0.8040085647066093 2 P02545 1 +Abnormal speech prosody 0.5873300821206772 1.3128884398905978 0.189220542792341 1.0 0.804587186685516 8 P03915,P00846 2 +Cutis laxa 0.4288071016339929 1.305913438421769 0.1915819960681364 1.0 0.8118542751195329 27 P51812,Q9Y487 2 +Middle age onset 0.5714224906155052 1.3028928744799515 0.1926113369392075 1.0 0.8148390387985806 9 P07602 1 +Abnormal urine protein level 0.396297320686159 1.2998370077400403 0.1936568385980568 1.0 0.8182217537153031 50 P35670,Q8N1F7,P35579,Q14C86,Q14108,P03915,P09601,P06280,O75431,P57740,Q8NFH4,Q12769,P21912,O43707,P00403,Q03252,P04062 17 +Neoplasm of the adrenal cortex 0.6594108288255198 1.2953743642799085 0.1951911171181928 1.0 0.820508932470528 5 P48735,O75874 2 +Widow s peak 0.7182232357894451 1.2940152322721006 0.1956601594079712 1.0 0.820508932470528 4 O15344,P98172 2 +Hemifacial spasm 0.7182229842040518 1.2940141978724131 0.1956605166980978 1.0 0.820508932470528 4 Q969G3,Q10713 2 +Impaired vibratory sensation 0.427088490770963 1.293506694899358 0.1958358700649938 1.0 0.820508932470528 28 Q9NR77,O14773,P00846 3 +Axial dystonia 0.8965112858828233 1.292880627623557 0.1960523486374874 1.0 0.820508932470528 3 Q99720 1 +Abnormal basal ganglia mri signal intensity 0.425788369126928 1.288526065693409 0.1975629013582696 1.0 0.8213181015593907 30 P16278,P00846,Q96CU9,Q8NI60,Q9BPX6 5 +Barrel shaped chest 0.7168522132420867 1.2883781320206211 0.1976143671968433 1.0 0.8213181015593907 4 Q32P28,P04066 2 +Serositis 0.4720811202943657 1.2866373073943214 0.1982207338669965 1.0 0.822516664140901 17 Q8N1F7,P14174,Q14C86,Q8NFH4,P57740,O43707,O15460 7 +Parkinsonism 0.4258308314389213 1.2827792993163458 0.1995694084862851 1.0 0.8253623935389018 24 P07602,P04062,P35637,Q15043,P17480,P61457,Q99720 7 +Dysphasia 0.470860337150783 1.278382601743819 0.2011145555377256 1.0 0.8284827663418344 17 P53701,P21964,P46100 3 +Generalized lipodystrophy 0.89204174820613 1.2764631051084698 0.2017918610418008 1.0 0.8305212942696901 3 O75844,P02545 2 +Thoracic kyphoscoliosis 0.6252421455798989 1.275729308880348 0.2020512242087153 1.0 0.8308375542891349 6 O75844,P02545 2 +Axial muscle weakness 0.7127618201942842 1.271559126286723 0.2035298071011735 1.0 0.8346555693013891 4 Q8TD16,P02545 2 +Abnormality of the peripheral nervous system 0.3645720808375444 1.2708406332763786 0.203785349942184 1.0 0.834909345052197 95 Q9NR77,P04062,P20700,P02545,P21964,P39210,P41227,P42892,P46100,Q10713,O00592,P07602,Q15067,Q9UBB4,P50570,Q96EK5,O95831,P41440,Q9H4A3,O15121,P06280,P07196,Q99720,O43681 24 +Slurred speech 0.5920156503293976 1.270354109742066 0.2039585219020305 1.0 0.834909345052197 7 Q9Y487 1 +Hypoplastic fingernail 0.4789573337127897 1.2669970243049398 0.2051563539000902 1.0 0.8370290345520552 15 Q969G3,Q14739,O60826,O75431,O14497,P51812,Q92785,Q15149 8 +Laryngomalacia 0.4781457516459594 1.2617141022111176 0.2070516805906974 1.0 0.8415003905872884 15 P07602,P21964 2 +Polydactyly 0.4078335681761269 1.2612121795422524 0.2072324116538555 1.0 0.8415003905872884 43 Q7Z4L5,Q10713,O60826,P61978,P21964,Q15067,O00459,P98175,Q00577,O43924,Q9H3P2,P98172,Q9UHX1,O96028 14 +Micromelia 0.4444176744721586 1.2598696272058914 0.2077163970906155 1.0 0.8427139389986469 21 Q7Z4L5,Q15392,P48735,Q96HY6 4 +Lagopthalmos 0.8869741836118112 1.2578576458890265 0.2084432434816134 1.0 0.8434076838473817 3 P02545 1 +Aphasia 0.4174742439540666 1.256810090255413 0.2088224114166297 1.0 0.8434424283660146 36 Q9UGU0,P53701,P03915,P21964,Q9H9P8,P00403,P46100,P22626,Q7LGA3 9 +Tapered finger 0.41605420580275 1.2542085004128116 0.209766231000974 1.0 0.8450797461813374 37 Q96EK5,Q06136,P23786,P51812,Q9NSE4,P42892,P46100,Q03252,Q03164 9 +Incomplete penetrance 0.4217719724237581 1.2522303412190408 0.2104859431025776 1.0 0.8466004789601692 29 Q969G3,P03915,Q14671,P00846,O14979,P21912,P36551,O43707,Q8WWY3,Q9UBB4,P50995 11 +Chromosomal breakage induced by ionizing radiation 0.7076235131548484 1.2504306929830555 0.2111422583230415 1.0 0.8482961693614168 4 Q969G3 1 +Abnormality of subcutaneous fat tissue 0.4758600618224815 1.24683135161518 0.2124593422012524 1.0 0.8495371165673896 15 O75844,Q9Y487,O75431,P02545 4 +Abnormality of the upper respiratory tract 0.360858567163499 1.245940171179927 0.2127863607352667 1.0 0.8495371165673896 93 P28070,P07602,Q92804,P54802,P16278,P35637,P02545,P21964,Q03519,Q13510,P00813,Q15165,Q96HY6,P46100,O15460 15 +Aplasia hypoplasia involving the femoral head and neck 0.586763723213342 1.244779760427933 0.213212717842083 1.0 0.8498636529046953 7 O95831,Q96HY6 2 +Myoclonic seizure 0.3824136100522684 1.2420932324661742 0.2142021652065993 1.0 0.8519435435532059 53 P07602,P16278,O75503,P03915,Q9UPT5,Q13510,P00846,Q01105 8 +Abnormality of the mitochondrion 0.3595476430435452 1.2403449359540213 0.214847838397872 1.0 0.8519435435532059 92 Q9Y2R0,P35637,O43772,P03915,P23786,P00846,O43676,Q96CU9,O96000,P00403,Q9Y584,Q70HW3 12 +Dermatological manifestations of systemic disorders 0.3368732829637834 1.239041620636951 0.2153300849557937 1.0 0.8519435435532059 67 P02545,O43772,O14936,P39210,P98175,P46100,P40855,Q15904,O75381,O75844,P36551,Q6NUQ1,Q16625,P04066,P56589,P51812,P00374,Q01082,P35670,O15118 20 +Areflexia 0.352293263085478 1.237311906910001 0.2159713090922657 1.0 0.8519435435532059 84 Q9NR77,O43819,P51114,O95721,Q8TD16,P02545,P39210,Q13586,Q16637,Q15067,Q13510,Q9Y5P6,Q92734,P50570,O95831,P41440,P06753,Q9H6K4,P56589,O75477,Q8NAT1,Q9H4A3,Q9BT22,Q15149,Q13217,P61978,P10253,P07196,O43505,Q9BQT8 30 +Polar cataract 0.88134726730651 1.2372114271055132 0.2160086002853409 1.0 0.8519435435532059 3 P08670 1 +Dental crowding 0.4346104417392977 1.237184035797117 0.2160187668593929 1.0 0.8519435435532059 22 P02545,P06753,O75431,Q96A33,Q01105,O75844,P51812,Q15233 8 +Anteriorly placed anus 0.5405056272046765 1.234438761665635 0.2170394527489225 1.0 0.8531637209957645 10 P53701,P16435 2 +Abnormal sharpey fiber morphology 0.6159745872667797 1.2330876723077682 0.2175430562866736 1.0 0.8531776986615054 6 P35670,P53680,P02545 3 +Abnormality of skeletal muscle fiber size 0.4587768884583353 1.2325925409365113 0.217727821224763 1.0 0.8531776986615054 18 O95831,P02545,P06753,P22626,Q9BPX6 5 +Limb joint contracture 0.3629822786552548 1.2297736597547848 0.2187818744709035 1.0 0.8541124293238019 97 Q9NR77,Q8TD16,P02545,Q99567,P41227,P21912,P42892,Q8IZA0,P98172,Q08J23,Q7LGA3,P35637,O00459,O75844,Q9Y5P6,Q15392,P06753,P16435,P37268,P07196,P23786,P50402,Q86XL3,Q99720 24 +Broad phalanx of the toes 0.6148775167788727 1.2280376342629766 0.219432840687435 1.0 0.8559197007790954 6 P98172,O14936,Q7LGA3 3 +Oculomotor apraxia 0.4261268611324647 1.226332879630402 0.2200734330725815 1.0 0.8576834480705404 23 Q10713,O43924,Q9NQT5,O14773,P04062 5 +Abdominal distention 0.4520922388970312 1.2254140313693964 0.2204192628897476 1.0 0.8577432595376719 19 P07602,Q01844,Q96HY6,P04062 4 +Acetabular dysplasia 0.5565127457011736 1.2252908770468522 0.2204656444769499 1.0 0.8577432595376719 9 P16278 1 +Increased adipose tissue 0.877313569082811 1.222420680527922 0.2215485826042211 1.0 0.8591333973937327 3 P02545 1 +Extrapyramidal muscular rigidity 0.6426329135716452 1.221893135660734 0.2217480416272921 1.0 0.8591333973937327 5 Q9H6K4,Q9BPX6 2 +Morphological abnormality of the pyramidal tract 0.4325191005117769 1.2213701777058974 0.2219458933290825 1.0 0.8591333973937327 22 O95831,P35637,P00846 3 +Chondrocalcinosis 0.6425078292358886 1.221345119477275 0.2219553768310698 1.0 0.8591333973937327 5 P35670,P53680,P02545 3 +Supernumerary bones of the axial skeleton 0.69988172939597 1.2186005979787111 0.2229958219857355 1.0 0.8593692065395517 4 Q9UHX1 1 +Fetal akinesia sequence 0.6418403934726719 1.218420951270835 0.2230640473620422 1.0 0.8593692065395517 5 Q99567,P04062 2 +Aortic valve calcification 0.8760600130463112 1.2178259585242768 0.2232901175446597 1.0 0.8593692065395517 3 O75844,P02545 2 +Mitral stenosis 0.8760600130463112 1.2178259585242768 0.2232901175446597 1.0 0.8593692065395517 3 O75844,P02545 2 +Abnormal caudate nucleus morphology 0.53740708168594 1.217588080737775 0.2233805461361875 1.0 0.8593692065395517 10 Q9BVA1,P00846,O75306 3 +Glomerular sclerosis 0.4171570764621832 1.2170161435993974 0.2235980736896685 1.0 0.8593692065395517 30 Q8N1F7,Q14C86,Q14108,P03915,Q8NFH4,O75431,P21912,P00403 8 +Tongue atrophy 0.6409006085803052 1.2143035304253875 0.2246318380051066 1.0 0.8593692065395517 5 P07196 1 +Intestinal hypoplasia 0.6979620057117403 1.210709233708228 0.2260068622741178 1.0 0.8594758701841576 4 O75844,P02545 2 +Stroke like episode 0.6110158740671059 1.210258971694392 0.2261795357582372 1.0 0.8594758701841576 6 P00403 1 +Spastic paraparetic gait 0.6978409226692408 1.2102115282058656 0.2261977356064632 1.0 0.8594758701841576 4 Q15043,P34897 2 +Retinal hemorrhage 0.6108487096711053 1.2094892786051512 0.2264749276169313 1.0 0.8598114015948887 6 Q9Y487 1 +Decreased ldl cholesterol concentration 0.6969800522458259 1.2066730683742188 0.2275580747651258 1.0 0.8602113551070241 4 Q15800 1 +Coxa vara 0.5028889739252019 1.2037642424586967 0.2286807139602762 1.0 0.8602113551070241 12 O95831,Q9Y487 2 +Perseveration 0.6384595341520836 1.203608520781731 0.2287409245645153 1.0 0.8602113551070241 5 P35637 1 +Calvarial skull defect 0.6083636859842625 1.19804657303096 0.2308988863970054 1.0 0.8602113551070241 6 Q14739,O96028,Q9H3P2 3 +Proportionate short stature 0.4143039461810817 1.196869245080588 0.2313575232153004 1.0 0.8602113551070241 31 P53701,Q15392,P16278,P10619 4 +Recurrent viral infections 0.471939357860379 1.1942098886205843 0.2323958759070159 1.0 0.8602113551070241 14 P00813 1 +Neoplasm of the nervous system 0.3968683027030968 1.1938212059847688 0.2325479146309064 1.0 0.8602113551070241 45 Q969G3,P02545,Q07954,P21912,Q9H9P8,Q01844,O43924,P20585,P46100,P48735,P78549 11 +Ambiguous genitalia 0.4531113855778838 1.193423678229604 0.2327034862407333 1.0 0.8602113551070241 18 P53701,Q15392 2 +Abnormality of the temporomandibular joint 0.8691445413877212 1.1924954428328562 0.2330670365780451 1.0 0.8602113551070241 3 P02545 1 +Protruding tongue 0.5324358265074259 1.1905394316504128 0.2338344413377817 1.0 0.8602113551070241 10 P46100,P20700,Q10713,O60826 4 +Dilated cardiomyopathy 0.4105765090103309 1.1885364560952958 0.2346221258056866 1.0 0.8602113551070241 35 P53701,P16278,P03915,P23786,P00846,P00403 6 +Secondary growth hormone deficiency 0.6921985020604482 1.1870231210796005 0.2352185006409037 1.0 0.8602113551070241 4 Q969G3 1 +Tube feeding 0.3513286197225156 1.1867519156795951 0.2353254905075095 1.0 0.8602113551070241 61 P07602,Q15233,P37268,P35637,P61978,P17480,Q01105,Q96N66,O15121,Q99720,Q08J23,Q9UHX1 12 +Hamartomatous polyposis 0.8682751874796211 1.1857003909136723 0.2357406401213508 1.0 0.8602113551070241 2 P21912 1 +Abnormality of the autonomic nervous system 0.3848923834720027 1.1853857302878783 0.2358649710952811 1.0 0.8602113551070241 50 P07602,Q96EK5,P20700,P41440,Q10713,O43681,P21964,P06280,Q15067,P41227,P42892,P46100,P04062,O00592 14 +Abnormal tricuspid valve morphology 0.4993595561234575 1.1829120994477689 0.2368439858852393 1.0 0.8602113551070241 12 P51812,P21964 2 +Abnormality of the pubic bone 0.6337175131395001 1.182833117615529 0.2368752926029489 1.0 0.8602113551070241 5 Q8IZA0,Q9H3P2 2 +Frequent falls 0.4077150827867546 1.1810023247636687 0.2376017997766921 1.0 0.8602113551070241 37 Q9NR77,P07602,P00846,Q13510,P21912,P04062,O43681 7 +Male pseudohermaphroditism 0.8659687605246333 1.1808735621369766 0.2376529553803905 1.0 0.8602113551070241 3 P53701 1 +Abnormality of the nasal tip 0.3615893314946274 1.1808672512083578 0.2376554628246738 1.0 0.8602113551070241 100 Q9UGU0,P02545,P21964,O14936,Q96A33,O43924,P42892,P46100,Q7LGA3,Q9UHX1,Q9Y487,Q92796,O75844,Q96EK5,O95831,O75431,P51812,P38159,Q03164,Q969G3,P16278,P61978,P23786,Q00577 24 +Hypertriglyceridemia 0.4270300845886638 1.1798421403696795 0.2380630056751356 1.0 0.8602113551070241 22 P28070,P22830,O75431,P02545 4 +Carcinoid tumor 0.6896792122801418 1.1766730958129843 0.2393260102218906 1.0 0.8602113551070241 4 P46100 1 +Emphysema 0.5470542634037838 1.1759744274868815 0.239605095109153 1.0 0.8602113551070241 9 Q03519,P02545 2 +Diarrhea 0.3392053409133711 1.1748040370396653 0.2400731246583163 1.0 0.8602113551070241 75 P54802,P03915,P39210,Q13510,P00813,Q13423,P00403,P42892,P46100,Q08J23 10 +Decreased activity of mitochondrial complex i 0.4098006280734536 1.1746826485913766 0.2401217037587804 1.0 0.8602113551070241 34 O43676,Q96CU9,O96000,Q9Y584,Q70HW3 5 +Psoriasiform dermatitis 0.6884862181925075 1.1717727754690546 0.2412882957003495 1.0 0.8602113551070241 4 Q15800 1 +Neck flexor weakness 0.8633762578187005 1.1713916431969222 0.2414413897902159 1.0 0.8602113551070241 3 Q99720 1 +Vegetative state 0.8633702250538979 1.1713695846647258 0.2414502524050648 1.0 0.8602113551070241 3 P07602 1 +Progressive peripheral neuropathy 0.8633702250538979 1.1713695846647258 0.2414502524050648 1.0 0.8602113551070241 3 P07602 1 +Abnormal gallbladder morphology 0.4116074774991972 1.170982687206463 0.2416057362089587 1.0 0.8602113551070241 30 P07602,P21964,P22830,Q96A33,P04062,O43681 6 +Elevated circulating long chain fatty acid concentration 0.8643625692859471 1.1703630103493352 0.2418549146667801 1.0 0.8602113551070241 2 P23786 1 +Abnormal intraocular pressure 0.6020370590759989 1.1689111717399567 0.2424394219584837 1.0 0.8602113551070241 6 Q15043,P04439 2 +Agitation 0.4098033282765334 1.1685683586152131 0.2425775827002432 1.0 0.8602113551070241 33 Q96CV9,Q92804,P35637,O96008,P35610,Q15165,P42892,P50995,P48449,Q01082,P04062,O00592 12 +Abnormal circulating porphyrin concentration 0.6875137037653939 1.167778541170271 0.2428961060833678 1.0 0.8602113551070241 4 P36551,P22830 2 +Supraventricular tachycardia 0.6015808076959475 1.1668099730116828 0.2432871186018275 1.0 0.8602113551070241 6 P41227,Q14BN4,P02545 3 +Biliary tract neoplasm 0.6872272577501799 1.16660215255188 0.2433710736623973 1.0 0.8602113551070241 4 P07602 1 +Neoplasm of the gallbladder 0.6872272577501799 1.16660215255188 0.2433710736623973 1.0 0.8602113551070241 4 P07602 1 +Elevated diastolic blood pressure 0.8620802086729848 1.161424866508857 0.2454691613556958 1.0 0.8602113551070241 2 P42892 1 +Elevated systolic blood pressure 0.8620802086729848 1.161424866508857 0.2454691613556958 1.0 0.8602113551070241 2 P42892 1 +Elevated mean arterial pressure 0.8620802086729848 1.161424866508857 0.2454691613556958 1.0 0.8602113551070241 2 P42892 1 +Respiratory distress 0.3824723281449749 1.1610674817471796 0.2456144576804342 1.0 0.8602113551070241 50 P07602,O95831,P53701,P10253,P03915,P23786,Q13510,P00846,Q00577,P16219,Q9UHX1 11 +Rectal prolapse 0.5571430156260162 1.160939048432694 0.2456666875305648 1.0 0.8602113551070241 8 P51812 1 +Acute hepatic failure 0.4623061955652858 1.1584821758163144 0.2466673213605308 1.0 0.861065680086761 15 Q6NUQ1,P39210 2 +Disturbance of facial expression 0.5996236366220592 1.157796582194299 0.2469470584813353 1.0 0.8613816170168878 6 Q9NR77 1 +Bruising susceptibility 0.4092561145754101 1.1546700242346597 0.2482255792560119 1.0 0.8643401771968574 31 Q14108,Q13126,Q9NWM8,P46100 4 +Hypoplastic fifth fingernail 0.5669310049180873 1.148083198447152 0.2509342194807917 1.0 0.8708671359681839 7 O14497,Q969G3,Q92785 3 +Distal peripheral sensory neuropathy 0.6253615624158404 1.146233327820955 0.2516986213333516 1.0 0.8708671359681839 5 P00403 1 +Dyschromatopsia 0.5663898045302695 1.1454431142413974 0.2520256472108682 1.0 0.8708671359681839 7 Q9H061 1 +Severe muscular hypotonia 0.4082723914231273 1.1433069042282438 0.2529111894361722 1.0 0.8708671359681839 30 P40855,O95831,Q8TD16,P02545,P06753,O75381,P56589,Q01105,Q00577,Q9NWM8 10 +Delayed menarche 0.596448536212751 1.1431748988216988 0.2529659818444094 1.0 0.8708671359681839 6 P02545 1 +Retrocollis 0.8551859099804218 1.141471308384021 0.2536738451279743 1.0 0.8708671359681839 3 P35637,Q99720 2 +Soft tissue sarcoma 0.4079256660573937 1.14042937993994 0.254107458533015 1.0 0.8708671359681839 30 Q07954,Q15392,Q13126,Q969G3 4 +Ocular pain 0.6806787393955891 1.1397195697950235 0.2544031513935485 1.0 0.8708671359681839 4 Q15043 1 +Inverted nipples 0.5398207575188344 1.1382328553788688 0.2550232627956039 1.0 0.8708671359681839 9 P61978,Q15067,P56589 3 +Pain 0.4099111266257284 1.1363519182864068 0.2558093101902257 1.0 0.871735405701703 171 Q9NR77,P14174,Q14C86,P02545,Q15043,P21964,O14936,P00846,P21912,O43707,Q96HY6,P42892,P46100,O15460,P07602,P35637,Q14108,Q13510,O75844,Q15165,Q03252,Q15800,Q70HW3,P28070,P50570,Q9H6K4,Q8NFH4,Q13423,P22626,P35670,Q8N1F7,Q969G3,Q92804,Q07954,P23786,Q14566,P50402,Q01844,P48735,P04062 40 +Abnormality of lysosomal metabolism 0.6793470625444257 1.1342557761636891 0.2566872737922905 1.0 0.8726951040921391 4 P07602 1 +Limb girdle muscle weakness 0.4074227444706952 1.1342042945967403 0.2567088630007412 1.0 0.8726951040921391 25 P07602,Q13126,Q8TD16,P02545,O14979 5 +Corneal opacity 0.3794593616071046 1.130783234780262 0.2581463380155511 1.0 0.8754453621323101 50 P02545,P40855,O75381,Q13510,O75844,Q16625,O75569,O96028,P04066,P56589,Q8NAT1,Q9H3P2,P35670,P53701,P16278,Q06136,P06280,O43505,P10619,P04062 20 +Dicarboxylic aciduria 0.40656052110954 1.1294761325423406 0.2586970324280619 1.0 0.8754453621323101 24 Q9H9P8,P23786,P48735,O43772 4 +Limb girdle muscular dystrophy 0.5381331407628734 1.1294258430524151 0.2587182361130749 1.0 0.8754453621323101 9 O14979,P02545 2 +Papillary thyroid carcinoma 0.5380502238170826 1.1289931232680428 0.2589007346197391 1.0 0.8754453621323101 9 O14497,Q969G3,Q12824,Q92785 4 +Limited wrist movement 0.6205075638071431 1.1249821325563538 0.2605966057377702 1.0 0.8756316102508557 5 O75844,P02545 2 +Progressive spasticity 0.4527897338513738 1.1244795414502726 0.2608096448664212 1.0 0.8756316102508557 16 P51812,P07602,O15121 3 +Delayed closure of the anterior fontanelle 0.4892415778204945 1.123105994606231 0.2613924804833027 1.0 0.8756316102508557 12 P51812,Q9Y487 2 +Cerebral palsy 0.5016730690821539 1.1198764201028015 0.2627664278564738 1.0 0.8756316102508557 11 Q9BVA1,P98175,P61457,P48735,Q01082 5 +Visual field defect 0.3870817553399833 1.1192098145958085 0.2630506393576373 1.0 0.8756629896801542 46 Q969G3,Q9H061,O75381,Q9BVA1,Q9H6K4,P03915,P00846,P56589,P00403,O15460 10 +Head tremor 0.4747644946510687 1.11895208203304 0.2631605821358636 1.0 0.8756629896801542 13 P07196,Q99720 2 +Somatic sensory dysfunction 0.3557150653260452 1.1180629636668835 0.2635401029677167 1.0 0.8757450791615342 99 Q9NR77,P20700,P02545,P39210,P00846,O15460,Q96BR5,P07602,Q8IV08,P17480,P50570,O95831,P41440,Q9H6K4,Q9NSE4,Q9H4A3,O14773,P54802,Q13217,P61978,P06280,P07196 22 +Prominent nasal bridge 0.3847804185783429 1.1166347461769626 0.2641505288442649 1.0 0.8764629301142954 47 P78318,Q96EK5,P20700,P21964,O14936,P49366,Q8WVM7,O43924,P42892,Q08J23,Q15233 11 +Infectious encephalitis 0.5180821440625759 1.112383928573936 0.2659731116875599 1.0 0.8773904615142284 10 P46100 1 +Decreased light and dark adapted electroretinogram amplitude 0.8471478085366178 1.1121661203936462 0.2660667318294338 1.0 0.8773904615142284 3 P50897 1 +Hyperlipidemia 0.4044648652001225 1.1117068463900144 0.2662642151775873 1.0 0.8773904615142284 30 P28070,P02545,P22830,O75431,P23786,O75844,P50402,O43707 8 +Abnormal glomerular mesangium morphology 0.4508648294619633 1.1116836023836678 0.2662742125551878 1.0 0.8773904615142284 16 Q8N1F7,Q14C86,Q8NFH4,P57740,P00813,O43707 6 +Increased circulating lactate dehydrogenase concentration 0.4870735977981304 1.110289405063946 0.2668743371497153 1.0 0.8777543227640925 12 P10253,P23786,P41440 3 +High myopia 0.5175096233145997 1.1092659181866842 0.2673154832050841 1.0 0.8780281449909485 10 Q9Y487 1 +Steppage gait 0.4298415652902798 1.108010084492141 0.267857460702481 1.0 0.8790349869703171 20 Q9NR77,P07196,P02545 3 +Abnormality of the vasculature of the eye 0.3318774742148633 1.1054815731463383 0.268950974600975 1.0 0.8790349869703171 73 P28070,P07602,P16278,P06865,P21964,Q13510,P00846,P10619 8 +Weight loss 0.3281374561108789 1.104886187841752 0.2692089080784599 1.0 0.8790349869703171 69 P35670,P07602,P02545,P35637,Q06136,O75844,Q13423,P42892,Q01844,P46100,Q99720,O15460,P04062 13 +Somatic mutation 0.3940569772732367 1.1043323157126566 0.2694490095655442 1.0 0.8790349869703171 41 Q92804,Q93052,P00813,P11717,P46100,Q01844 6 +Cns demyelination 0.4721252982522316 1.1027315970315008 0.2701437409435185 1.0 0.8790349869703171 13 P07602,Q9H9P8,Q15067 3 +Hyporeflexia 0.3690347790957993 1.1018692596804422 0.2705185145357101 1.0 0.8790349869703171 117 Q9NR77,P04062,Q8TD16,P02545,Q9BUK6,P39210,P00846,Q96BR5,Q10713,O00592,P07602,P35637,Q15067,O14979,Q9UBB4,P50570,O95831,P41440,P06753,Q9NSE4,Q8NAT1,Q9H4A3,P54802,Q96F07,P03915,P07196,O43505,Q99720,O43681 29 +Abnormality of skull ossification 0.4855761860453466 1.1014373241053128 0.2707063685434772 1.0 0.8790349869703171 12 Q32P28,Q14739,P54802,P02545,O75844 5 +Limb muscle weakness 0.3369987791625105 1.101360737688368 0.2707396862329492 1.0 0.8790349869703171 79 Q9NR77,P35670,P50570,Q13126,Q969G3,P02545,P07196,P39210,Q15067,P00846,Q13510,P50402,Q9BQT8,Q96BR5,Q99720 15 +Delusions 0.4391550502844848 1.0968662965624347 0.2726998438532102 1.0 0.8816261997299808 18 P07602,P21964,P36551,P04062,O43681 5 +Tetraplegia 0.4705059580943811 1.0927798487927878 0.2744904712904468 1.0 0.8828130272771877 13 O95831 1 +Ureterocele 0.6688417618270672 1.0911964641961895 0.2751864433986641 1.0 0.8828130272771877 4 O14936,Q15149,P09471 3 +Arnold chiari type i malformation 0.6685225235124591 1.0898893343911251 0.2757618953746386 1.0 0.8828130272771877 4 Q15043 1 +Angina pectoris 0.8405088062622246 1.0880121968335774 0.2765897231313312 1.0 0.8828130272771877 3 O75844,P02545 2 +Increased serum pyruvate 0.4002021394992132 1.0870121531417098 0.277031438741677 1.0 0.8828130272771877 33 O95831,P22695,Q96CU9,O96000,Q9BWD1,O43676,Q5JRX3,Q70HW3 8 +Oval face 0.583573842557253 1.0839111896950742 0.2784041777926282 1.0 0.8828130272771877 6 O14936,Q9UHX1 2 +Dyskinesia 0.3244774852804525 1.0821457984187963 0.2791877482164782 1.0 0.8828130272771877 67 O43819,Q15043,O14936,P00846,P35610,Q08J23,Q9BPX6,O00592,P09471,Q9UBB4,O75569,Q01105,Q96F07,P03915,O75306,Q96N66,Q00577,Q9UBX3,P04062 19 +Inability to walk 0.3415970299319876 1.0810371025060446 0.2796806098012183 1.0 0.8828130272771877 86 Q9NR77,P35637,O75503,P61978,P07196,P00846,Q13510,Q96CU9,Q96N66,Q99720 10 +Skin dimple 0.4137942066491394 1.0796491343463197 0.2802984527117886 1.0 0.8828130272771877 22 P53701,P61978,P49366,Q9H3P2,Q08J23,Q03164,O96028 7 +Long fingers 0.3334528982215867 1.0794189115426924 0.2804010241327521 1.0 0.8828130272771877 77 Q9UGU0,Q96EK5,Q969G3,Q9H3P2,P55795,Q06136,P21964,P23786,P51812,Q9NSE4,P42892,Q03164,Q9H4A3,P46100,Q03252,Q9UHX1,P07437 17 +Follicular hyperkeratosis 0.5816944762730809 1.0752661284417848 0.2822555963268072 1.0 0.8828130272771877 6 Q9NWM8 1 +Abnormality of the biliary system 0.3597074370850588 1.0752497751615484 0.2822629158655976 1.0 0.8828130272771877 108 P14174,P02545,P21964,P22830,P39210,O14936,Q96A33,P55263,Q10713,P07602,P40855,Q15904,Q14108,P09601,O75381,Q13510,P36551,Q6NUQ1,Q16625,Q5XKP0,O96028,P04066,P56589,P00374,Q9H3P2,Q01082,P35670,O15118,P04062,O43681 30 +Mediastinal lymphadenopathy 0.6089877880299852 1.0745964721236283 0.2825554320162928 1.0 0.8828130272771877 5 O15460 1 +Autoamputation 0.5518018609732238 1.0742910835128052 0.2826922400913365 1.0 0.8828130272771877 7 P39210,Q9H4A3 2 +Aortic valve stenosis 0.5393524166873656 1.0712445012447869 0.2840595069205243 1.0 0.8828130272771877 8 O75844,P04062,P16278,P02545 4 +Cold induced muscle cramps 0.8357208314305196 1.0706241874152982 0.28433844337422 1.0 0.8828130272771877 3 Q9NR77 1 +Dermal atrophy 0.399693278004498 1.0696497668424654 0.2847769851549313 1.0 0.8828130272771877 27 P53701,P02545,Q07954,Q15392,Q9NWM8 5 +Calvarial hyperostosis 0.6075007894134079 1.068099176564766 0.2854757772773899 1.0 0.8828326370461124 5 Q15043 1 +Telecanthus 0.3925610367227455 1.0670055112316723 0.2859693472689899 1.0 0.8828326370461124 39 Q96EK5,P02545,O15344,P21964,O00459,O75844,P51812,Q00577,P46100,P98172,Q86XL3,Q08J23,Q03164 13 +Painless fractures due to injury 0.8346994247590944 1.0669184968782908 0.2860086415023706 1.0 0.8828326370461124 3 P39210 1 +Orofacial dyskinesia 0.5798511121680081 1.0667887188535234 0.2860672538758821 1.0 0.8828326370461124 6 O75569,Q9BPX6 2 +Stillbirth 0.4918924821267193 1.064144252355706 0.287263356686154 1.0 0.8857859835397071 11 O75844,P04062,P16435,P02545 4 +Myopathic facies 0.5784104637729299 1.060164889891816 0.2890695909972767 1.0 0.888483982592575 6 Q00577,Q9BUK6,P06753 3 +Abnormality of the lymph nodes 0.3927629117418129 1.0586725288128134 0.2897489430086426 1.0 0.8890647152581331 38 P28070,P14174,P33991,Q13510,P00813,P46100,O15460 7 +Tetraplegia tetraparesis 0.3787890672563696 1.058462864869243 0.2898444721975108 1.0 0.8890647152581331 47 P07602,O95831,P35637,P00846,Q13423,Q9H9P8,Q9UBX3,O43681 8 +Esophageal varix 0.6049208603409169 1.0568307978375864 0.290588815873734 1.0 0.8895496233068171 5 P35670 1 +Severe global developmental delay 0.3223786776913404 1.055562496730515 0.2911681425633263 1.0 0.8907240490243694 67 Q9UGU0,O00584,O75381,P03915,O14936,Q15067,Q96A33,P00846,P56589,P51812,P07942,Q00577,P55263,O15121,Q7LGA3 15 +Heteronymous hemianopia 0.6035376776000181 1.050791891683432 0.2933541806023414 1.0 0.8944442753814401 5 Q969G3 1 +Abnormality of the thymus 0.441504789026641 1.0494822878963286 0.2939562029812466 1.0 0.8944442753814401 16 P21964 1 +Aplasia hypoplasia of the thymus 0.441504789026641 1.0494822878963286 0.2939562029812466 1.0 0.8944442753814401 16 P21964 1 +Transient ischemic attack 0.5348999265870799 1.0488082944834836 0.2942663591887955 1.0 0.8947898911338658 8 O75844,P02545 2 +Extra axial cerebrospinal fluid accumulation 0.8324095207042668 1.0459326115673804 0.2955921464334547 1.0 0.8976220484089967 2 Q03252 1 +Periorbital fullness 0.4208489772418793 1.043061832319809 0.2969196563749912 1.0 0.8986557684966489 20 Q92796,P51812,P38159,Q7LGA3,P07437 5 +Optic nerve hypoplasia 0.431266812528799 1.042309857920534 0.2972680434142218 1.0 0.898670046590976 18 P61978,P37268,P07196,Q9UHX1 4 +Thick eyebrow 0.3853225449066801 1.0376716852768104 0.299422931478464 1.0 0.8995783482885823 42 Q96EK5,O95831,O60885,Q969G3,Q16531,P04066,O14497,P51812,Q12824,P98175,P15586,Q9NSE4,Q92785,Q03164,Q08J23,Q01082,Q9Y4W2,Q9UHX1 18 +Abnormal atrioventricular valve morphology 0.3942226243730725 1.0321463189829243 0.3020035780047261 1.0 0.9001333590422982 32 Q15233,P53701,P55795,P02545,P06753,P21964,O75431,O75844,P51812,P04062 10 +Agenesis of lateral incisor 0.8278447994783171 1.0283026461306115 0.3038074867294815 1.0 0.9001333590422982 2 Q12959 1 +Pseudoarthrosis 0.5983518438375621 1.0281675285850729 0.3038710299337834 1.0 0.9001333590422982 5 O75844,P02545 2 +Anarthria 0.5422928277702094 1.02795473811367 0.3039711191329166 1.0 0.9001333590422982 7 Q99720 1 +Optic disc coloboma 0.8238747553816043 1.0277320934324243 0.3040758668481418 1.0 0.9001333590422982 3 P78318,P41227 2 +Abnormality of the musculature of the thigh 0.5305825443016011 1.0270638958008822 0.3043903779306751 1.0 0.9001333590422982 8 O14979,P07196,P02545 3 +Underdeveloped supraorbital ridges 0.4728996968395541 1.0265359871737456 0.3046390096597913 1.0 0.9001333590422982 12 P40855,O75381,P56589,P98175,Q08J23 5 +Abnormality of temperature regulation 0.3517021952028091 1.0265239392513013 0.3046446855022231 1.0 0.9001333590422982 103 Q9NR77,P14174,Q14C86,O43772,O14936,P00846,P00813,O15460,P07602,Q13510,P28070,P50570,Q8NFH4,P00403,Q8N1F7,P61978,P03915,P10253,P23786 19 +Abnormality of the intervertebral disk 0.597377712307279 1.0239208460555862 0.3058726631324657 1.0 0.9001333590422982 5 P02545 1 +Abnormal prostate morphology 0.570408845870019 1.0234042999202169 0.3061167271905249 1.0 0.9001333590422982 6 O60934,P25054,Q8IWS0 3 +Meningitis 0.5290766985521412 1.0194829109348011 0.3079737620973999 1.0 0.9001333590422982 8 O15460,P02786 2 +Inappropriate behavior 0.4408895076405125 1.0188396336546224 0.3082791062955179 1.0 0.9001333590422982 15 P07602,P46100 2 +Abnormal ilium morphology 0.4315744640744458 1.012236596830539 0.3114249418770323 1.0 0.90338250100007 17 P51812,O95831 2 +Abnormal chorioretinal morphology 0.3924544899838785 1.0121942829041066 0.3114451692110915 1.0 0.90338250100007 26 P40855,P53701,O60826,O75381,O14936,O43505,P04439,P56589,P41227,Q8NAT1,Q5XKP0,Q10713 12 +Lipid accumulation in hepatocytes 0.3198101778651878 1.0112685560474204 0.3118879114005679 1.0 0.90338250100007 68 P35670,Q8N511,P02545,O43772,P23786,P39210,Q15067,O75431,Q6NUQ1,P55263,Q03252,P16219 12 +Abnormality of the supraorbital ridges 0.4043640518498236 1.008321189045232 0.3133002939677984 1.0 0.90338250100007 22 P40855,O75381,P56589,P38159,P51812,P98175,Q08J23 7 +Short lingual frenulum 0.81849182274587 1.0083087447661323 0.3133062661961641 1.0 0.90338250100007 3 P02545 1 +Overtubulated long bones 0.81849182274587 1.0083087447661323 0.3133062661961641 1.0 0.90338250100007 3 P02545 1 +Cognitive impairment 0.390474613692532 1.007861231623871 0.313521085425622 1.0 0.90338250100007 157 P04062,P20700,P21964,P00846,P21912,P27544,Q10713,O00592,P07602,P40855,P35637,Q14108,Q9Y487,O75381,Q9BVA1,P17480,P50897,Q13510,Q9Y5P6,Q9UBB4,Q5XKP0,O75569,Q9Y2R0,O95831,O75503,Q9H6K4,P57740,P56589,P00403,Q03164,Q01082,P22626,P35670,Q969G3,P54802,P16278,Q96F07,Q13217,P06865,P03915,P07196,P06280,O96008,O75306,O15118,Q9UEY8,Q6DKK2,Q99720,O43681 49 +Increased circulating antibody level 0.4306597394626732 1.0060469770425278 0.3143929728616976 1.0 0.90338250100007 17 P00813,Q14108 2 +Abnormal sacrum morphology 0.3916342965863163 1.0042531849977727 0.3152565924882926 1.0 0.90338250100007 27 P53701,P61978,P04066,P49366,Q9H3P2,Q8TAA9,Q08J23,Q03164,O96028 9 +Recurrent pancreatitis 0.817148910202881 1.003470199314049 0.3156340484525874 1.0 0.90338250100007 3 P00403 1 +Abnormal thyroid morphology 0.3883366755018976 1.003150930121481 0.3157880445427485 1.0 0.90338250100007 36 Q969G3,P02545,P00813,P21912,P42892,P48735 6 +Limb girdle muscle atrophy 0.4420950697170011 1.0031491905102023 0.3157888837608189 1.0 0.90338250100007 14 O14979,P50402,P02545 3 +Corneal erosion 0.5924910290039078 1.0026344865120602 0.3160372500433093 1.0 0.90338250100007 5 P39210 1 +Corneal ulceration 0.5923644962576492 1.002083706518642 0.3163031665065938 1.0 0.90338250100007 5 O75844,P02545 2 +Concentric hypertrophic cardiomyopathy 0.8163647297627791 1.0006461372148836 0.3169979163040151 1.0 0.90338250100007 3 P00403 1 +Abnormally lax or hyperextensible skin 0.3838268320875191 0.9994258294062324 0.3175884525829942 1.0 0.90338250100007 40 P04062,Q9Y487,P41227,O96000,P51812,Q9NWM8,Q9UHX1,P07437 8 +Progressive cerebellar ataxia 0.3858571180769297 0.9975026536816686 0.3185205863655542 1.0 0.90338250100007 38 P41440,P35637,Q9Y487,Q96CU9,O14773 5 +Decreased adipose tissue 0.4373598751143457 0.9958623042030258 0.3193170530169542 1.0 0.90338250100007 15 O75844,O75431,P02545,Q03252 4 +Pain in head and neck region 0.5356162297794586 0.9954617010686524 0.3195117624738741 1.0 0.90338250100007 7 Q15043,Q969G3,P29992 3 +Progressive external ophthalmoplegia 0.4964520410106564 0.9946709458292632 0.3198963297103976 1.0 0.90338250100007 10 P03915,P00403 2 +Abnormal visual fixation 0.5353351250849483 0.9940946102833208 0.3201768090673982 1.0 0.90338250100007 7 Q5KU26,Q13510 2 +Macular degeneration 0.4406074463726873 0.993643105823007 0.3203966504384128 1.0 0.90338250100007 14 P50897,P04439,Q13510,Q8WWY3,P04062 5 +Abnormality of the knee 0.3328588828546599 0.9934712102860976 0.3204803737693091 1.0 0.90338250100007 84 Q9NR77,P37268,O95831,Q8TD16,P16278,P06753,P21964,P23786,O75431,O00459,Q13510,P21912,Q9NSE4,Q96HY6,P46100,Q86XL3,Q7LGA3 17 +Pigmentary retinopathy 0.3804631999926145 0.9929655117629016 0.3207267618800515 1.0 0.9034333045037096 42 P53701,Q9BUK6,P03915,Q15067,P00846,O75306,Q96CU9,P21912,Q9Y5P6,Q9UG56,P00403 11 +Beaking of vertebral bodies 0.5109999379205371 0.9879228579643482 0.3231904298308814 1.0 0.9047316197866264 9 P16278 1 +Positional foot deformity 0.3375810930201118 0.9871605131155604 0.323563956112245 1.0 0.9047316197866264 90 Q9NR77,Q9H3P2,Q8TD16,P02545,P06753,P61978,Q9Y487,P21964,P07196,Q96A33,P32929,P98175,Q6NUQ1,Q8NI60,P46100,Q15392,Q9NWM8,Q9UHX1 18 +Exaggerated startle response 0.5225786442142495 0.9867927895163028 0.3237442302642823 1.0 0.9047316197866264 8 P06865,P16278 2 +Congenital muscular dystrophy 0.8167590479295788 0.9856732588416878 0.3242934758602029 1.0 0.9047316197866264 2 P02545 1 +Decreased pulmonary function 0.6428523987011626 0.9851508502524154 0.3245499788211443 1.0 0.9047316197866264 4 Q12824,Q969G3 2 +Abnormality of the pharynx 0.3711382969083733 0.984241826154324 0.3249966250341507 1.0 0.9047316197866264 47 P54802,P16278,P21964,Q03519,Q13510,P00813,O15460 7 +Scanning speech 0.8154548418650318 0.980676620471547 0.3267522366818944 1.0 0.9047316197866264 2 O14773 1 +Brachydactyly 0.3192859548626027 0.9796734895258168 0.3272473162087592 1.0 0.9047316197866264 65 Q7Z4L5,O95831,P02545,Q13868,Q06136,P51812,P21912,Q9NSE4,O43924,P46100,P48449,Q08J23,P16435,Q9UHX1 14 +Pseudoepiphyses 0.80943090093866 0.9757207538386712 0.329202864687709 1.0 0.9078771526114114 3 P51812 1 +Pseudoepiphyses of hand bones 0.80943090093866 0.9757207538386712 0.329202864687709 1.0 0.9078771526114114 3 P51812 1 +Pseudoepiphyses of the metacarpals 0.80943090093866 0.9757207538386712 0.329202864687709 1.0 0.9078771526114114 3 P51812 1 +Reduced forced vital capacity 0.6404145355463804 0.9752508298603316 0.3294358541707227 1.0 0.9078771526114114 4 Q9BQT8 1 +Angiokeratoma 0.8082191780821781 0.9713736044539496 0.3313622678454808 1.0 0.9078771526114114 3 P06280,P16278 2 +Generalized onset motor seizure 0.3563389710542525 0.9702215260244876 0.3319360831686451 1.0 0.9078771526114114 53 P07602,P16278,P03915,O14936,Q01105,Q13510,P00846,Q96N66,Q00577,P04062 10 +Dyspnea 0.3378919452575493 0.969573469251402 0.3322591426224064 1.0 0.9078771526114114 92 P02545,P00846,Q96CV9,P46100,P16219,Q9UHX1,P07602,P35637,Q13510,O75844,Q15165,P50995,O95831,Q8TCJ2,P53701,Q92804,P03915,P10253,P23786,Q00577,P04062 21 +Bird like facies 0.5302305212732741 0.9692853981029972 0.3324028126832337 1.0 0.9078771526114114 7 P02545 1 +Widened cerebral subarachnoid space 0.8070009456814536 0.967005812897634 0.333541127771102 1.0 0.9078771526114114 3 P00403 1 +Focal t2 hyperintense brainstem lesion 0.4148275782095844 0.9622745976575215 0.3359116856302317 1.0 0.9078771526114114 19 O43676,Q96CU9 2 +Rib segmentation abnormalities 0.8055481632612449 0.9618006889111844 0.3361497319362849 1.0 0.9078771526114114 3 Q9H3P2 1 +Hypoplastic pubic rami 0.8055481632612449 0.9618006889111844 0.3361497319362849 1.0 0.9078771526114114 3 Q9H3P2 1 +Aplasia hypoplasia of the pubic bone 0.8055481632612449 0.9618006889111844 0.3361497319362849 1.0 0.9078771526114114 3 Q9H3P2 1 +Abnormality of abdominal situs 0.8055481632612449 0.9618006889111844 0.3361497319362849 1.0 0.9078771526114114 3 Q9H3P2 1 +Pruritus 0.3854768145478113 0.9617689053998136 0.3361657008077579 1.0 0.9078771526114114 24 P00813,Q07954,P22830 3 +Abnormal brain lactate level by mrs 0.4902015346339279 0.9607284186598352 0.3366887382488865 1.0 0.9078771526114114 10 P03915,P21912,P00403,O75306 4 +Irritability 0.3221840727830017 0.9602684838626958 0.3369201074582046 1.0 0.9078771526114114 75 Q5KU26,P07602,O95831,Q8N1F7,P37268,Q14C86,P25705,O43772,Q15067,P50897,P00846,Q13510,Q8NFH4,P21912,P61457 15 +Gingival bleeding 0.4891895515213457 0.9552380155121132 0.3394573452550289 1.0 0.9080856375171268 10 Q14108,P04062 2 +Absence of subcutaneous fat 0.5264389424110474 0.9508795200679974 0.3416655392476673 1.0 0.9080856375171268 7 P02545 1 +Abnormality of circulating leptin level 0.8024894002491769 0.9508547037700484 0.3416781384704452 1.0 0.9080856375171268 3 P02545 1 +Unsteady gait 0.3591204988447875 0.9490990485620036 0.3425702382674274 1.0 0.9080856375171268 51 Q9NR77,O95831,Q96F07,O75503,Q9H6K4,P07196,P49366 7 +Abnormality of the spleen 0.3566938041242909 0.9487456943037226 0.3427499677654071 1.0 0.9080856375171268 117 P28070,P07602,P35670,Q16625,P54802,P16278,P33991,P14174,Q14108,P21964,Q13510,P00813,Q6NUQ1,Q96HY6,P46100,O15118,P10619,Q15392 18 +Enlarged ovaries 0.8017182879037973 0.948098102967318 0.3430795139271292 1.0 0.9080856375171268 3 P21912 1 +Contractures of the joints of the lower limbs 0.3516470086900354 0.9480077584631058 0.3431255045099863 1.0 0.9080856375171268 54 P37268,Q8TD16,P02545,P35637,P23786,O00459,P50402,P21912,Q8IZA0,Q86XL3,Q08J23,Q7LGA3,Q99720 13 +Joint subluxation 0.5794074594264566 0.9458069352323496 0.3442470676252152 1.0 0.9098020241565712 5 P16278 1 +Genital neoplasm 0.383732561023811 0.9439439448435256 0.3451982939733362 1.0 0.9098020241565712 32 P02545,P48735,P21912,Q13423,Q01844,P78549 6 +Hemorrhage of the eye 0.4586713863727368 0.9426590734038616 0.3458553134852804 1.0 0.9098020241565712 12 Q9Y487 1 +Abnormal circulating long chain fatty acid concentration 0.5781937479250331 0.9405493941248934 0.3469358258012012 1.0 0.9102884571969112 5 O75381,P23786,P56589 3 +Poor head control 0.3187183119046409 0.9394802156092104 0.3474842453617046 1.0 0.9102884571969112 73 Q5KU26,P07602,Q15233,Q96F07,P02545,P06753,P06865,O14936,P09471,O43676,Q96CU9,O96000,P21912,Q9Y5P6,P00374,Q9NQT5,Q9NWM8,Q10713 18 +Hyporeflexia of lower limbs 0.5015636976209109 0.9388512124933228 0.3478071408601311 1.0 0.9102884571969112 9 Q9NR77 1 +Polymicrogyria 0.3231152903977478 0.9380198627944834 0.3482342025766654 1.0 0.9102884571969112 78 Q8TD16,Q08J23,Q10713,P07437,P40855,O75381,Q9Y487,Q9BVA1,O00459,Q16625,Q15392,Q96EK5,Q01105,P56589,Q8NAT1,P37268,P23786,O43505,Q96N66 19 +Atelectasis 0.485969791322129 0.9377803257970888 0.3483573138042661 1.0 0.9102884571969112 10 P21964 1 +Small earlobe 0.5124666276766889 0.9360211341364936 0.3492623064717741 1.0 0.9110842516100376 8 P21964 1 +Bowing of the legs 0.3695488434328278 0.9345095268694522 0.3500411240118632 1.0 0.911158089434564 45 Q9NR77,Q32P28,Q13126,P16278,O75431,Q96HY6,P46100,Q7LGA3 8 +Abnormality of circulating glucocorticoid level 0.4446851259665609 0.93441225574335 0.3500912782120062 1.0 0.911158089434564 13 Q969G3,Q13423 2 +Abnormality of the gallbladder 0.3802994864110393 0.9333427456723584 0.3506430314938138 1.0 0.9115517300741522 36 P07602,P40855,O43681,P21964,P22830,Q96A33,Q9H3P2,P04062,O96028 9 +Aplasia hypoplasia of the optic nerve 0.3880589938635651 0.9312673505193738 0.3517152864249286 1.0 0.91381734235518 23 P37268,Q8N3U4,O95721,O75312,P61978,Q9NVI7,O14936,P07196,P49454,Q9Y5P6,P25054,Q9UHX1 12 +Abnormalities of placenta or umbilical cord 0.4306732003030216 0.9302694157423848 0.3522316089768178 1.0 0.9146367849757414 14 P16278,P02545,O60826,O75844,P16435 5 +Spontaneous recurrent epistaxis 0.8020867297032878 0.9297105891615672 0.3525209503280369 1.0 0.9148528267331838 2 P04062 1 +Widened subarachnoid space 0.3825074950267661 0.9293325637493408 0.3527167642611462 1.0 0.9148528267331838 28 O95831,P03915,Q01105,P51812,P00403 5 +Xanthomatosis 0.8017606781871611 0.9284735255381176 0.3531619945335216 1.0 0.915485990385302 2 P02545 1 +Shallow orbits 0.484141366960059 0.9278743980759449 0.3534727261470785 1.0 0.9156340832313128 10 P61978,O75844,P02545 3 +Metaphyseal cupping 0.8011085751548941 0.926000303134754 0.3544458227147538 1.0 0.9161031241614334 2 O95831 1 +Giant platelets 0.8011085751548754 0.9260003031346822 0.3544458227147911 1.0 0.9161031241614334 2 P35579 1 +Soft skin 0.5097898444222038 0.9226068856206106 0.3562121060707179 1.0 0.917644316261408 8 Q13126 1 +Papule 0.4219769674079155 0.9200705725719244 0.357535881133399 1.0 0.9189284654915886 16 Q07954,P21912,P02545,O75844 4 +Episodic respiratory distress 0.7938533695952363 0.9200516126407932 0.3575457885170729 1.0 0.9189284654915886 3 P00846 1 +Echolalia 0.5198706608622684 0.919046560456966 0.3580712191202386 1.0 0.9189284654915886 7 P53701,Q01082,Q9UHX1 3 +Recurrent sinopulmonary infections 0.5473282771491208 0.9177890346689924 0.358729324072617 1.0 0.9189284654915886 6 Q9Y487 1 +Abnormal erythrocyte sedimentation rate 0.5082826536638712 0.9150593628165876 0.3601604669542562 1.0 0.9214982481770408 8 P28070,P14174 2 +Atrophy degeneration involving the corticospinal tracts 0.4413334303773226 0.9139372052265784 0.3607498425202999 1.0 0.9214982481770408 13 P00846 1 +Neurofibrillary tangles 0.7975220084773575 0.9124195054369788 0.3615479253976814 1.0 0.9214982481770408 2 O15118 1 +Acanthosis nigricans 0.4812384014600445 0.9121597679633712 0.3616846192622518 1.0 0.9214982481770408 10 P28070,P02545 2 +Oral aversion 0.4963747119156824 0.9119239620188336 0.3618087465636401 1.0 0.9214982481770408 9 O14497,P35610,Q969G3,Q92785 4 +Chondrosarcoma 0.7913354871391693 0.9111006500891732 0.3622423439597328 1.0 0.9214982481770408 3 Q92804 1 +Adducted thumb 0.3913306474531792 0.9100293546215072 0.3628070290650191 1.0 0.9214982481770408 22 P34897,Q9Y5S9,Q9UNE7,Q8NBU5,P57740,Q92917,P42892,Q86XL3 8 +Infantile spasms 0.3799828199290899 0.9087958992980748 0.3634578715727405 1.0 0.9214982481770408 28 P03915,Q13813,Q13510,P00846,Q9UBX3 5 +Aplasia cutis congenita of scalp 0.5688265701526021 0.9000684330255547 0.3680838337776007 1.0 0.9285051129780248 5 O96028,Q9H3P2 2 +Fatigue 0.3207415999555542 0.8970248869160727 0.3697056373429688 1.0 0.9290483375786004 79 P21912,Q96CV9,P46100,O15460,O00592,P07602,P35637,P43243,Q15165,P50995,P53680,Q70HW3,Q4J6C6,P06753,Q13423,Q01082,Q14739,Q92804,Q6UN15,P06280,P04062 21 +Abnormal circulating pyruvate family amino acid concentration 0.4099404806707696 0.8953051446504064 0.3706239909124167 1.0 0.9290483375786004 18 P03915,P00846,O96000,P25705 4 +Abnormality of the periorbital region 0.3124955116852849 0.8952758050965502 0.3706396707035893 1.0 0.9290483375786004 65 P28070,Q8N1F7,Q14C86,O75381,Q92796,Q8NFH4,P56589,P38159,P51812,P98175,O43707,Q08J23,Q7LGA3,P07437 14 +Hypoventilation 0.4501861105549842 0.8928165246757 0.3719554355379151 1.0 0.9293729650051232 12 O43819,P06753,P61978,O75306,Q00577,Q8N183 6 +Myotonia 0.5140505223596354 0.8909042830990411 0.3729805223261415 1.0 0.9297959132686726 7 P50402,P02545 2 +Headache 0.319119241579302 0.8892519443215702 0.3738676918669559 1.0 0.9309438679798973 63 Q8N1F7,Q969G3,Q14C86,P03915,P23786,Q8NFH4,P00846,P21912,O43707,P00403,O15460,P04062 12 +Gastrostomy tube feeding in infancy 0.3776340633244412 0.8892265382601044 0.3738813430094749 1.0 0.9309438679798973 29 O15121,Q99720,P35637,Q01105 4 +Abnormal macroscopic urine appearance 0.4131677929924684 0.8880348143263519 0.3745220246142426 1.0 0.9309438679798973 17 Q8N1F7,Q14C86,P23786,Q8NFH4,P57740,P36551,O43707 7 +Cupped ear 0.43702466012227 0.8876589830067803 0.3747242156582664 1.0 0.9309438679798973 13 P42892 1 +Abnormal oral frenulum morphology 0.4239479484485502 0.8875057061385674 0.3748066954504541 1.0 0.9309438679798973 14 O43924,P02545 2 +Lipoma 0.5406471519849414 0.8873832327597897 0.3748726076465623 1.0 0.9309438679798973 6 P21912,Q9BUK6 2 +Cough 0.3765482605918873 0.8844167348972696 0.3764712924029809 1.0 0.9318671494948594 26 Q9NR77,O15460,P41440 3 +Paralysis 0.3589428902666985 0.8843332533862917 0.3765163424606463 1.0 0.9318671494948594 48 Q9NR77,P04062,P20700,Q92804,P02545,P35637,P10253,P50402,P21912,P36551,Q15165,Q96CV9,P50995,Q15233 14 +Fasting hypoglycemia 0.783697029615042 0.8840348384135618 0.3766774066499432 1.0 0.9318671494948594 3 O43772 1 +Abnormal acetabulum morphology 0.412339906388058 0.8824713133935888 0.3775219860957752 1.0 0.9334492562237746 17 Q9Y584,P16278 2 +Abnormal pharynx morphology 0.3735420425422876 0.8812790187471332 0.3781668193311929 1.0 0.9341475177388142 37 Q13428,Q969G3,P54802,P16278,P29372,P43243,O15344,Q03519,Q13510,P00813,P15586,O15460 12 +Morphological abnormality of the corticospinal tract 0.4195503594839682 0.8803270391822086 0.3786821687842192 1.0 0.9347945945259034 15 P00846 1 +Platyspondyly 0.3757715536378714 0.8772458980798772 0.3803530910762993 1.0 0.9373942991766728 32 O95831,P16278,P00813,Q6NUQ1,Q96HY6,P48735 6 +Prenatal movement abnormality 0.3334315615581359 0.8706224320110543 0.383960344150384 1.0 0.9406918944425648 58 Q93009,P51114,Q8TD16,P02545,Q16637,Q99567,P40855,O75844,Q9Y5P6,Q70HW3,O96028,P50570,Q4J6C6,P06753,P56589,Q9H3P2,O60885,Q96F07,P43897,P04062 20 +Abnormality of neutrophil morphology 0.5369317257641077 0.8705162150097526 0.3840183618051824 1.0 0.9406918944425648 6 P35579,P41440 2 +Agenesis of incisor 0.779272397594599 0.8684210901345177 0.3851638534073518 1.0 0.9406918944425648 3 Q12959 1 +Thickened ribs 0.6138430878481291 0.868091472402276 0.3853442590268086 1.0 0.9406918944425648 4 P54802 1 +Abnormal atrioventricular conduction 0.4176094445970533 0.8677918076893805 0.3855083156328627 1.0 0.9406918944425648 15 P02545,O43772,P50402,P21912,Q14BN4 5 +Asymmetric septal hypertrophy 0.7854581023801963 0.8670273148062589 0.385927043691292 1.0 0.9406918944425648 2 P54802 1 +Multiple prenatal fractures 0.5090947446628098 0.8669974897395294 0.3859433851049334 1.0 0.9406918944425648 7 Q32P28,Q14739,O75718,P06753 4 +Abnormal choroid morphology 0.3746330176664643 0.8668378569068198 0.3860308565067467 1.0 0.9406918944425648 27 P40855,P53701,O60826,O75381,O14936,O43505,P04439,P56589,P41227,Q8NAT1,Q5XKP0,Q10713 12 +Telangiectasia 0.3739195428776495 0.8644693920854605 0.3873300874152212 1.0 0.941772208562094 33 P03915,P00846,P46100,P10619,Q8IZA0 5 +Diminished movement 0.4008329143122963 0.8640277183131703 0.3875726639821715 1.0 0.941772208562094 19 P51114,O95831,P06753,Q99567,P04062,O00592 6 +Disproportionate short trunk short stature 0.6126003417085673 0.8631191137912899 0.3880719799244339 1.0 0.941772208562094 4 P16278 1 +Rimmed vacuoles 0.4168698746831198 0.8630190196380523 0.3881270097772078 1.0 0.941772208562094 15 Q9BTV4,P02545,P43243,P09651,O14979,P50402,P22626,Q9H173 8 +Arm dystonia 0.7768213925489595 0.8597933218795715 0.3899029811509695 1.0 0.9425588795534856 3 Q99720 1 +Abnormality of the calf 0.3402955693898891 0.85535277499254 0.3923558792054771 1.0 0.9449756413456782 55 Q9NR77,O95831,Q32P28,Q13126,P16278,O75431,Q96HY6,P46100,Q7LGA3 9 +Neoplasm of the endocrine system 0.3712261464985843 0.8548332124375485 0.3926434887601875 1.0 0.9450810918359668 36 Q969G3,P02545,P21912,P42892,P46100,P48735 6 +Abnormal femoral neck morphology 0.3703686554195552 0.8536238907754651 0.3933134167932235 1.0 0.9450810918359668 37 O95831,P16278,P02545,Q9Y487,O75431,O75844,P51812,Q96HY6,P46100 9 +Facial edema 0.3716322713751708 0.8522549411706807 0.3940726088733162 1.0 0.9450810918359668 24 P28070,Q8N1F7,Q14C86,Q8NFH4,P57740,O43707,Q01082 7 +Epistaxis 0.4113410824666321 0.8500019140123762 0.3953240221132255 1.0 0.94584764650763 16 P35579,Q6UN15,Q13586,O15460,P12814,Q96EV8,P04062 7 +Myositis 0.4952499565385139 0.8499917569641992 0.3953296691401768 1.0 0.94584764650763 8 P28070,P22626 2 +Abnormal parotid gland morphology 0.7808933811542182 0.8499763563655618 0.3953382315235281 1.0 0.94584764650763 2 P16615 1 +Benign neoplasm of the central nervous system 0.3987969955605763 0.8497956045168135 0.3954387338268934 1.0 0.94584764650763 19 Q969G3,P78549,O43924,P02545 4 +Abnormal lung lobation 0.4307439895425042 0.8494571584768189 0.3956269593476553 1.0 0.94584764650763 13 P21964 1 +Short middle phalanx of finger 0.773664261741198 0.8487032173449172 0.3960464554977732 1.0 0.9463535251579336 3 Q9UHX1 1 +Abnormal glycosylation 0.3830353079629602 0.84777701321048 0.3965621670741288 1.0 0.9465920212487856 22 Q9Y487,Q8N511 2 +Abnormal blood transition element cation concentration 0.4536592623484557 0.8472799117685617 0.3968391208202817 1.0 0.946717034367895 11 P35670,Q15904,Q9Y487 3 +Prostate neoplasm 0.5564621409921713 0.8469365363869363 0.3970304961793303 1.0 0.946717034367895 5 O60934,P25054,Q92878,P49959 4 +Short umbilical cord 0.7726294029638057 0.8450738929857441 0.398069583609395 1.0 0.947016497981638 3 P02545 1 +Small placenta 0.7726294029638057 0.8450738929857441 0.398069583609395 1.0 0.947016497981638 3 P02545 1 +Kyphoscoliosis 0.3487581234891974 0.8442120285893372 0.3985509341206821 1.0 0.947016497981638 51 Q5KU26,Q9NR77,P02545,Q9Y487,O75844,P51812,P46100,Q9NWM8 8 +Flat face 0.3715035302315967 0.8441020319074274 0.3986123923841869 1.0 0.947016497981638 26 O75381,Q9Y487,P56589,P46100,Q03164,P07437 6 +Neoplasm of the peripheral nervous system 0.4020332445036744 0.8411452321249728 0.4002665779426189 1.0 0.9489603972655968 18 Q07954,Q969G3,P02545,P46100 4 +Axonal loss 0.5303489876287152 0.8407151830663951 0.4005075126878066 1.0 0.9489603972655968 6 P41440 1 +Progressive sensorineural hearing impairment 0.4679363522334027 0.8403979690405632 0.4006852875043418 1.0 0.9489603972655968 10 P03915,P00403 2 +Aplasia hypoplasia of toe 0.3712270150994177 0.8393074301771751 0.4012968147914568 1.0 0.9494230728317122 32 Q9UGU0,P02545,Q13510,P00813,Q03164,Q7LGA3,Q9UHX1 7 +Spastic tetraparesis 0.3699414668836215 0.8389408414833972 0.4015025077330945 1.0 0.9494230728317122 24 P00846 1 +Absent thumbnail 0.6056237127956206 0.8352827513131451 0.4035585267571342 1.0 0.9498922999683692 4 O14936 1 +Abnormal leukocyte physiology 0.3075309002150435 0.8337568730842413 0.4044180023010053 1.0 0.9498922999683692 65 P28070,P14174,Q14108,P21964,P09601,P00813 6 +Personality changes 0.4119590297973386 0.8313825901403649 0.4057575310467394 1.0 0.9498922999683692 15 P35670,P03915,P00403,P04062 4 +Elbow flexion contracture 0.3686648528230271 0.8288990941758064 0.407161507998325 1.0 0.9498922999683692 24 P37268,P02545,P06753,P23786,P50402,Q7LGA3 6 +Abnormal shape of the palpebral fissure 0.4802657668369349 0.8286919595982742 0.4072787366539443 1.0 0.9498922999683692 9 P55795 1 +Periorbital edema 0.3746895292955153 0.8284111954235974 0.407437668404611 1.0 0.9498922999683692 23 P28070,Q8N1F7,Q14C86,Q8NFH4,P57740,O43707,Q01082 7 +Narrow mouth 0.3070121927024209 0.8266501696411405 0.4084353726055703 1.0 0.9498922999683692 70 Q9UGU0,Q15233,P02545,Q9Y487,P21964,O00459,O75431,O75844,Q9NSE4,Q14004,Q15392,Q7LGA3,P04062,P07437 14 +Focal dystonia 0.3906191927540142 0.8259307988036676 0.4088433483209504 1.0 0.9498922999683692 20 Q13428,P35637,Q15043,P41227,Q99720,Q01082,O75569 7 +Loss of ability to walk 0.4498505451703064 0.8258580615079711 0.4088846132145098 1.0 0.9498922999683692 11 P21912,P00846 2 +Peritonitis 0.4384250459960231 0.8240659672088299 0.4099020763197785 1.0 0.9498922999683692 12 Q8N1F7,Q14C86,Q8NFH4,P57740,O43707 5 +Minimal change glomerulonephritis 0.4384250459960231 0.8240659672088299 0.4099020763197785 1.0 0.9498922999683692 12 Q8N1F7,Q14C86,Q8NFH4,P57740,O43707 5 +Abnormality of the wrist 0.3686133477920003 0.8210687573002717 0.4116071048076581 1.0 0.9498922999683692 26 O95831,P16278,P02545,Q13510,O75844 5 +Depression 0.3325562334865228 0.8194156933917857 0.4125492842197849 1.0 0.9498922999683692 100 P20700,Q9BUK6,P21964,P46100,Q96CV9,O15460,Q08J23,O00592,P07602,P35637,P50897,P36551,Q15165,P50995,P51812,P00403,P35670,Q92804,P03915,P06280,Q96N66,Q6DKK2,P04062,O43681 24 +Abnormal elasticity of skin 0.3259025048597878 0.8193404786644527 0.4125921839474302 1.0 0.9498922999683692 59 P04062,Q13126,P02545,Q9Y487,O75844,O96000,P51812,Q9NWM8,Q9UHX1 9 +Abnormal heart sound 0.6014285757045743 0.8186119011690143 0.4130078747151198 1.0 0.9498922999683692 4 P10253 1 +Abnormal epiphyseal ossification 0.4099528701840749 0.8184886023451399 0.4130782475458265 1.0 0.9498922999683692 15 P40855,O75381,P56589,Q9UG56,Q96HY6 5 +Abnormal peripheral nervous system morphology 0.3744133571006039 0.8180946621002605 0.4133031366212649 1.0 0.9498922999683692 156 Q9NR77,P02545,Q15043,P39210,P00846,P21912,P46100,P16219,Q96BR5,Q9UHX1,Q9BPX6,P07602,P40855,P35637,Q8IV08,O75381,Q92796,Q15067,Q13510,P50570,O95831,P41440,P56589,P51812,P00403,O15121,P22626,Q969G3,Q07954,P03915,P07196,Q9BQT8,Q6DKK2,Q99720,O43681 35 +Hemangiomatosis 0.7717639387023283 0.816097835310803 0.4144441819161351 1.0 0.9498922999683692 2 P48735 1 +Lymphangioma 0.7717639387023283 0.816097835310803 0.4144441819161351 1.0 0.9498922999683692 2 P48735 1 +Visceral angiomatosis 0.7717639387023283 0.816097835310803 0.4144441819161351 1.0 0.9498922999683692 2 P48735 1 +Restless legs 0.5996854303066597 0.8117007253394855 0.4169633780510962 1.0 0.9505852369272106 4 P07196 1 +Abnormality of the calf musculature 0.4014335559789915 0.8094427575230105 0.4182605163286186 1.0 0.9509694880125408 17 Q9NR77,P50570,P02545,P43243,Q9Y5P6,Q8NAT1 6 +Intestinal polyp 0.4013136229537674 0.8086427733486724 0.4187206538872978 1.0 0.9509694880125408 17 P21912,P78549,P42892 3 +Abnormal rectum morphology 0.3672138617932482 0.8072806691696209 0.4195047985503657 1.0 0.9509694880125408 27 P53701,P51812,P41227,P21912,P20585,P78549,Q8TAA9,Q08J23,Q16531 9 +Sagittal craniosynostosis 0.5983560313410039 0.8064364124511478 0.4199912586590395 1.0 0.9509694880125408 4 P61978 1 +Exercise intolerance 0.3674917135605935 0.8062816797703339 0.4200804514466105 1.0 0.9509694880125408 30 Q9Y2R0,P06753,P03915,P23786,Q9Y5P6,Q8NI60,P00403,Q8NFF5 8 +Increased circulating acth level 0.5469261146972051 0.8062416664651992 0.4201035181861168 1.0 0.9509694880125408 5 P46100 1 +Abnormal tricuspid valve physiology 0.3965456194875682 0.8037243396312201 0.421556194073311 1.0 0.9509694880125408 18 P53701,O75431,P46100 3 +Abnormality of the peritoneum 0.4041878482941643 0.803134610088035 0.4218969352621498 1.0 0.9511831655922056 16 Q8N1F7,Q14C86,Q8NFH4,P57740,O43707,Q01844 6 +Macroglossia 0.3667583728523667 0.8021243924083294 0.4224810063406388 1.0 0.9511831655922056 32 P16278,P61978,P10253,Q96A33,P04066,P21912,Q9Y5P6,P46100,Q7LGA3,Q10713 10 +Rhizomelia 0.4602093618909695 0.7989454087252889 0.4243220672410885 1.0 0.9525292502761444 10 Q15392,Q14739,Q03164 3 +Aplasia hypoplasia of the patella 0.5960310556921511 0.797243443808198 0.4253096595236303 1.0 0.952618671963271 4 Q96AY3,Q9Y5S9 2 +Lissencephaly 0.3438681998864781 0.794960073778172 0.4266367275238929 1.0 0.952618671963271 51 Q96EK5,P20700,Q9Y487,Q9BVA1,O14936,P09471,O00459,P07942,P23786,O43505,Q9Y5P6,Q8NAT1,Q16625,Q15392,Q86XL3 15 +Abnormal femoral neck head morphology 0.3546506844789374 0.7940935561563611 0.4271409686869147 1.0 0.952618671963271 45 O95831,P16278,P02545,Q9Y487,O75844,P51812,Q6NUQ1,Q96HY6,P46100,Q7LGA3 10 +Biliary cirrhosis 0.5198522613373427 0.7934459062511353 0.4275180737114961 1.0 0.952618671963271 6 P09601 1 +Abnormality of the musculature of the upper limbs 0.3043589440742534 0.793384492603843 0.4275538429007333 1.0 0.952618671963271 70 Q9NR77,P07602,P50570,Q8TD16,P02545,P06753,Q9Y487,P07196,O14979,P50402,Q9BQT8,P46783 12 +Pulmonary infiltrates 0.4936955271552547 0.7931169365987776 0.4277096960491036 1.0 0.952618671963271 7 Q13510 1 +Hypoplasia of the odontoid process 0.5197606178268904 0.7930347216020166 0.4277575934738413 1.0 0.952618671963271 6 O95831 1 +Neurogenic bladder 0.5196338046186832 0.7924657839345323 0.4280891349907603 1.0 0.952890827617575 6 P50336,P56589 2 +Medulloblastoma 0.5194014895010777 0.7914236584579687 0.4286968086807508 1.0 0.952917037109652 6 P35222,Q12824,P25054 3 +Motor deterioration 0.5434242566756571 0.7913685951659618 0.4287289305800894 1.0 0.952917037109652 5 O75503 1 +Pulmonary carcinoid tumor 0.7563414340716839 0.7883584050884946 0.4304870936546336 1.0 0.9542130800108436 3 P46100 1 +Abnormal arterial physiology 0.364322627462857 0.7869728472496899 0.4312977612961122 1.0 0.9545264444924147 26 Q14739,P02545,P06280,O75844,O15460,Q9NWM8 6 +Abnormal subarachnoid space morphology 0.3648580933626831 0.7851402743483987 0.4323713286427146 1.0 0.9545264444924147 31 O95831,P03915,Q01105,P51812,P00403 5 +Prolonged neonatal jaundice 0.3974395219041955 0.7828431852539918 0.4337192042876165 1.0 0.9552354910377824 17 Q15904,O14936,P39210,P56589,O15118 5 +Weakness of muscles of respiration 0.3637899926974686 0.7794982099289711 0.4356862916513542 1.0 0.9571640924695772 33 P50570,O95831,Q8TD16,P02545,P06753,P10253,Q15067,Q13510,P50402,P36551,P22626 11 +Recurrent acute respiratory tract infection 0.76133029018587 0.7777737969328073 0.4367023779509997 1.0 0.9580677927730812 2 Q03519 1 +Axillary pterygium 0.7613302901858461 0.7777737969327215 0.4367023779510504 1.0 0.9580677927730812 2 P98172 1 +Ovarian neoplasm 0.3966368253311871 0.7775081919962268 0.436859003182616 1.0 0.9580677927730812 17 Q01844,P48735,P02545 3 +Abnormal placental size 0.5909202112599679 0.7770990409335776 0.4371003397785504 1.0 0.9580677927730812 4 P02545 1 +Limited extraocular movements 0.5161852330073327 0.7770148633150613 0.4371500012279634 1.0 0.9580677927730812 6 Q9BVA1,O75306 2 +Ovoid vertebral bodies 0.4895838662545733 0.7735140990653683 0.4392181879370822 1.0 0.9595603894944608 7 P54802 1 +Disproportionate short limb short stature 0.395720035061153 0.7714195595339631 0.4404582851915797 1.0 0.9595603894944608 17 Q15392,Q32P28,Q7LGA3 3 +Abnormal length of corpus callosum 0.7593739810890063 0.7706380962901177 0.4409214736580296 1.0 0.9595603894944608 2 P48449 1 +Abnormal circulating bilirubin concentration 0.3620225031824631 0.7687492568689351 0.442042177576452 1.0 0.9595603894944608 26 P40855,P41440,O14936,P23786,P36551,P55263,Q01082 7 +Premature graying of hair 0.478326507015233 0.7661852742253715 0.4435660691407359 1.0 0.9605674342191388 8 Q13126 1 +Abnormality of the tarsal bones 0.3770823019990796 0.7645294374979302 0.4445518010245266 1.0 0.9619673429865075 21 P02545,Q99567,Q9UPT5,O75844,P98175,Q9UHX1 6 +Retinal thinning 0.7570916204760304 0.7623339984036509 0.4458606873456048 1.0 0.9619673429865075 2 P04439 1 +Shuffling gait 0.4277724128383344 0.7622460845418271 0.4459131458825842 1.0 0.9619673429865075 12 P41227,P04062,P02545,O75844 4 +Abnormality of circulating enzyme level 0.3210967753637618 0.7606706295586593 0.4468538217049351 1.0 0.9626495960250188 92 P02545,O43772,Q9BUK6,P39210,Q13586,Q9Y584,Q8NFF5,Q08J23,Q96BR5,Q9BPX6,P43243,O14979,Q9Y5P6,P53985,Q07021,Q92734,P50570,O95831,P06753,Q14126,Q16836,Q8NAT1,Q9NWM8,Q15149,P22626,P10253,P07196,P23786,O43505,P50402,Q5JRX3 31 +Focal t2 hyperintense basal ganglia lesion 0.3711414809051379 0.7591637153437663 0.4477546285222884 1.0 0.9638330336567682 22 Q96CU9,P00846 2 +Abnormal autonomic nervous system physiology 0.3615862558303761 0.758098880563324 0.4483917898177194 1.0 0.9638330336567682 30 P07602,P20700,P41440,O43681,P06280,Q15067,P42892,P04062,O00592 9 +Abnormal vitreous humor morphology 0.4766001181451126 0.757690887723741 0.4486360553647226 1.0 0.9638330336567682 8 P53701,P04439 2 +Abnormal synaptic transmission at the neuromuscular junction 0.3603040076276015 0.7551608148445207 0.4501524970703636 1.0 0.9651880200962296 26 Q92734,Q92804,P35637,P06753,P43243,Q13586,Q9Y5P6,Q15165,P29992,Q96CV9,P50995,Q14203,Q15149 13 +Abnormality of upper limb joint 0.3322210025170159 0.7546539511597087 0.4504566431665384 1.0 0.9653854235847849 106 Q9NR77,P02545,Q99567,P41227,P42892,Q8IZA0,P98172,Q7LGA3,Q13510,O75844,Q15392,O96028,O95831,P06753,Q9H6K4,Q03164,P16435,Q15233,P37268,P16278,P07196,P23786,P50402,Q8WVM7 24 +Hypocalciuria 0.7541571568307799 0.7516910689896134 0.4522368624947517 1.0 0.9666830023037528 2 P53680 1 +Hypermagnesemia 0.7541571568307799 0.7516910689896134 0.4522368624947517 1.0 0.9666830023037528 2 P53680 1 +Proximal amyotrophy 0.3994188380949147 0.7511212762197945 0.4525796722885609 1.0 0.9667492577463768 15 P07196,P35637,P02545,O14979 4 +Abnormal systemic blood pressure 0.3202574705985463 0.7503024294114837 0.4530725797795099 1.0 0.9668946944005292 92 P20700,P02545,O43772,P21964,P49366,P35610,P21912,P07686,O43707,P42892,P46100,Q10713,P07602,P35611,O75844,P36551,P50336,Q13423,P00403,Q9H4A3,Q8TAA9,P16435,P03915,P06280,P04062,O43681 26 +Erlenmeyer flask deformity of the femurs 0.583966463343536 0.7498409085691518 0.4533505272398466 1.0 0.9670202184281792 4 P07602 1 +Membranoproliferative glomerulonephritis 0.7531790022823703 0.7481520241654831 0.4543684651626001 1.0 0.9678452285541206 2 Q03252 1 +Aplasia hypoplasia involving bones of the thorax 0.3595794890423203 0.742698062025495 0.4576645033300235 1.0 0.969121735252807 32 Q7Z4L5,P02545,O60826,O75431,P41227,O75844,P98175,Q96HY6,Q03164,Q8TAA9,P98172,P16435,Q9UHX1 13 +Orthostatic hypotension 0.4009349038891794 0.7425237367685316 0.4577700756293619 1.0 0.969121735252807 14 P07602,P20700,P04062,O43681 4 +Weak voice 0.5313263477505971 0.7403207518671794 0.4591053920703818 1.0 0.9704624188102152 5 P43243,P04062,O00592 3 +Low set posteriorly rotated ears 0.3062611554299242 0.7357015823699324 0.4619123264721274 1.0 0.9740335563647023 63 P40855,P37268,P04062,Q4J6C6,O75381,P56589,P41227,P98175,O43924,Q9H3P2,Q15392,Q08J23,P16435,Q10713,P07437 15 +Abnormality of visual evoked potentials 0.3778724529809421 0.7355884303417657 0.4619812056659473 1.0 0.9740335563647023 20 O75503,P07602,Q15067 3 +Aspiration 0.4711273124756842 0.7308415337679314 0.4648759510586648 1.0 0.9756833580780528 8 P29372,P06865,O15344 3 +Abnormality of dental color 0.739510548875066 0.7306537104862052 0.4649906962718595 1.0 0.9756833580780528 3 P16278 1 +Increased intramyocellular lipid droplets 0.5056712706504989 0.7301767805522335 0.4652821336098416 1.0 0.9756833580780528 6 Q8NI60,Q9BUK6 2 +Abnormality of the odontoid process 0.4795412380089746 0.7258996142594866 0.467900313007588 1.0 0.9770101948672206 7 O95831 1 +Abnormal thoracic spine morphology 0.3571660195751676 0.724799216223319 0.4685752166851267 1.0 0.977106602924124 28 O95831,P04062,P02545,O00459,O75844,Q9NSE4,Q9UHX1 7 +Anorexia 0.3555568884527034 0.7217432037396627 0.4704523744326749 1.0 0.977106602924124 25 Q14108,Q6UN15,P06280,Q13423,P46100,O15460,P04062 7 +Impaired mastication 0.4785674231100651 0.7213044251096461 0.4707222349876065 1.0 0.977106602924124 7 O15460 1 +External ear malformation 0.3904696989783807 0.7140430436560099 0.475200563518527 1.0 0.9832331659710614 16 P40855,O75381,P56589,Q00577,P32929,P07437 6 +Toe syndactyly 0.326616134243138 0.7107172536802374 0.477259465691179 1.0 0.9852331991352996 55 Q7Z4L5,P37268,P51812,O43924,Q08J23,Q9UHX1 6 +Genu valgum 0.3553367161045188 0.7072064590152928 0.479438185252754 1.0 0.9884069833652792 31 Q9NR77,P16278,O75431,P46100,Q7LGA3 5 +Coarse facial features 0.2971491482558048 0.7059535444575544 0.4802170276627584 1.0 0.9893144539698896 65 O95831,P54802,P16278,P51812,P38159,P46100,P10619,Q7LGA3 8 +Abnormal metatarsal morphology 0.363864761213884 0.7054497821449949 0.4805303729629671 1.0 0.9893144539698896 22 O43505,Q8NAT1,Q03252,Q15392,Q08J23,P16435 6 +Multiple joint contractures 0.3732378631137515 0.7030274219986513 0.48203866038831 1.0 0.990227970702918 20 Q15043,O75844,P41440,P02545 4 +Heart block 0.3524311447791474 0.702224199082303 0.4825393565226357 1.0 0.9903152168129116 24 P02545,O43772,Q07954,P23786,Q14BN4 5 +Short stepped shuffling gait 0.7309197651663284 0.7016018625721746 0.4829274897488655 1.0 0.9904978904171412 3 P04062,O00592 2 +Congenital onset 0.3245676805483763 0.7007298300301694 0.4834716362973994 1.0 0.9904978904171412 102 Q5KU26,P78318,Q8TD16,P25705,Q99567,P41227,O43924,Q9NQT5,Q7LGA3,Q9UHX1,P07437,P07602,Q9Y5P6,Q03252,Q5XKP0,Q4J6C6,P50570,Q96EK5,P06753,Q8NFH4,P36404,P08670,Q8TCJ2,P46977,O43505,Q96N66 26 +Abnormality of the basal ganglia 0.3101882919171744 0.7001420709429355 0.4838385844366075 1.0 0.9904978904171412 85 O95831,P16278,P03915,P23786,P00846,Q96CU9,Q96N66,P00403,Q8NI60,Q08J23,Q9BPX6 11 +Progressive hearing impairment 0.4168548374580409 0.6994733293892458 0.4842562750075005 1.0 0.9904978904171412 12 P03915,P00403 2 +Bilateral cleft palate 0.7394848386044938 0.6990806756057344 0.484501614453761 1.0 0.9904978904171412 2 Q12959 1 +Non midline cleft palate 0.7394848386044938 0.6990806756057344 0.484501614453761 1.0 0.9904978904171412 2 Q12959 1 +Abnormality of thalamus morphology 0.3847461152374588 0.6989705453995676 0.4845704385282228 1.0 0.9904978904171412 17 Q969G3,Q9UPT5,O75306,Q9Y5P6,Q96EY7 5 +Abnormal pyramidal sign 0.3417014366311758 0.6978874100311327 0.4852476085199415 1.0 0.9909587770223302 124 Q9NR77,Q15043,P00846,P21912,P07602,P35637,P17480,Q92796,Q15067,Q8NI60,O95831,P41440,O75027,Q9H6K4,P51812,O15121,O14773,P07196,Q9H9P8,Q6DKK2,Q99720,O43681 22 +Osteopenia 0.3010211535157082 0.695610505954656 0.4866727849833421 1.0 0.9911797963620824 75 P07602,Q32P28,Q13126,P02545,P61978,Q14108,Q9Y487,O75431,O75844,Q9NSE4,Q9NWM8 11 +Paroxysmal involuntary eye movements 0.367463145265666 0.6952485563113914 0.486899547349332 1.0 0.9911797963620824 21 O43676,Q96CU9 2 +Abnormal lactate dehydrogenase level 0.3797981263068938 0.690656109070114 0.4897816778357255 1.0 0.9911797963620824 18 P41440,P10253,P23786,Q5JRX3,Q8NAT1 5 +Profound global developmental delay 0.3925547924125036 0.6904642160909957 0.4899023056383615 1.0 0.9911797963620824 14 P46100,P37268,O75381,P56589 4 +Abnormal renal tubule morphology 0.3617644826314345 0.6900322525596514 0.4901739051227571 1.0 0.9911797963620824 22 P03915,P06280,P23786,P57740,P00846,O75306 6 +Emg abnormality 0.2995789397630424 0.6888368640376296 0.4909259343171921 1.0 0.9911797963620824 74 Q9NR77,P07602,P50570,P02545,P03915,P07196,P39210,Q13510,P50402,Q8NI60,O14773,P22626 12 +Short palpebral fissure 0.3522890429456121 0.6887018987017067 0.4910108811013014 1.0 0.9911797963620824 27 P55795,P02545,O75844,P98175,Q03164,Q14004,Q9UHX1,P07437 8 +Abnormal activity of mitochondrial respiratory chain 0.3311840613973797 0.688467615293215 0.491158357136932 1.0 0.9911797963620824 52 Q9Y2R0,O43676,Q96CU9,O96000,Q70HW3 5 +Muscle flaccidity 0.7266530835446453 0.6872831042060891 0.4919043438170762 1.0 0.9911797963620824 3 Q15149 1 +Episodic pain 0.391453509245514 0.6836601337737644 0.4941898029508453 1.0 0.9911797963620824 14 Q13423,P23786,P46100 3 +Kinetic tremor 0.3523363455648367 0.6832133513526166 0.4944720372220208 1.0 0.9911797963620824 32 P07602,P20700,P41440,Q14108,O75027,Q9UBB4,Q15233,O43681 8 +First degree atrioventricular block 0.566702655973252 0.6830124267985485 0.494598990168996 1.0 0.9911797963620824 4 P02545 1 +Immunologic hypersensitivity 0.3522712222915453 0.6827160252101133 0.4947863015034002 1.0 0.9911797963620824 30 P00813,P21964 2 +Abnormality of earlobe 0.3520336066904045 0.6820120992891595 0.4952313002227519 1.0 0.9911797963620824 29 P53701,Q15392,P21964,Q7LGA3 4 +Abnormal muscle fiber protein expression 0.4701639606373454 0.6818303385205098 0.4953462380944959 1.0 0.9911797963620824 7 P50402,P02545 2 +Constriction of peripheral visual field 0.3606170170898511 0.6816268449148162 0.4954749358008485 1.0 0.9911797963620824 22 O75381,Q9H061,P56589,P00846 4 +Transposition of the great arteries 0.5662428256924226 0.6812505308524716 0.4957129792861803 1.0 0.9911797963620824 4 P02545 1 +Knee flexion contracture 0.3515549518920187 0.680186347133403 0.4963864760216558 1.0 0.9911797963620824 28 P37268,Q8TD16,P23786,O00459,P21912,Q86XL3,Q7LGA3 7 +Truncal titubation 0.7336159113139894 0.6783380128621962 0.4975574019828763 1.0 0.9911797963620824 2 Q6PJG6 1 +Meningocele 0.4373822476832213 0.6779090293493455 0.4978293745961903 1.0 0.9911797963620824 10 Q9Y5P6,P21964,Q10713 3 +Abnormal femoral head morphology 0.3776929953538195 0.6765926632680002 0.4986644353693028 1.0 0.9911797963620824 18 O95831,Q6NUQ1,P16278,Q7LGA3 4 +Porencephalic cyst 0.5159205535115169 0.6761871992381631 0.4989217987806515 1.0 0.9911797963620824 5 P07942 1 +Volvulus 0.515914864465963 0.6761637200972586 0.4989367040444721 1.0 0.9911797963620824 5 O60885,P46100 2 +Metopic synostosis 0.7230307622952972 0.675186882510826 0.4995570395505779 1.0 0.9911797963620824 3 P61978 1 +Visual fixation instability 0.7228720310974633 0.6746581134522102 0.4998930022789163 1.0 0.9911797963620824 3 Q13510 1 +Optic disc pallor 0.3352246779580817 0.6714773037479025 0.5019165133062748 1.0 0.9925307721126296 49 O95831,Q9H061,Q9BUK6,Q9H6K4,Q6P4Q7,O14936,P04439,P00846,O43676,Q96CU9,O96000,O75306,Q9UG56,Q10713 14 +Megalocornea 0.4219867437533002 0.6710307669025943 0.5022009297655736 1.0 0.9925307721126296 11 Q96EK5,Q9Y5P6,Q9H3P2 3 +Back pain 0.3539319298767628 0.6709785522005156 0.5022341928805587 1.0 0.9925307721126296 23 P35670,Q969G3,P02545,P50402,P36551,Q8TAA9,P50336 7 +Complete duplication of phalanx of hand 0.5632807241723217 0.66992520903861 0.5029054686991841 1.0 0.9925307721126296 4 P41227 1 +Thin clavicles 0.7214182906820052 0.6698204957513297 0.5029722264124974 1.0 0.9925307721126296 3 P02545 1 +Advanced eruption of teeth 0.4357068352474171 0.6691298112839722 0.5034126747836383 1.0 0.9925307721126296 10 P51812,P02545 2 +Rhabdomyolysis 0.4113084355587293 0.6678589217301287 0.5042236509141098 1.0 0.9929913785693728 12 O43772 1 +Gaze evoked nystagmus 0.4481604465440977 0.6654056932242757 0.505791044503888 1.0 0.9929913785693728 9 Q9Y4W6,P41440,Q10713,Q9UBB4 4 +Large intestinal polyposis 0.4572275067056021 0.6632619151447399 0.5071628236839283 1.0 0.9929913785693728 8 P21912,P78549 2 +Abnormal aortic arch morphology 0.4204630608617458 0.6626861966506554 0.5075315520198558 1.0 0.9929913785693728 11 P21964,Q9UHX1 2 +Abnormal posterior segment imaging 0.7188519243313662 0.6613031679061414 0.5084179102913702 1.0 0.9929913785693728 3 Q8WWY3,P04439 2 +Upper limb spasticity 0.4657134370792525 0.6610654076429822 0.508570368296692 1.0 0.9929913785693728 7 Q99720 1 +Abnormal cry 0.45646439721549 0.6595803122729095 0.5095231918399481 1.0 0.9929913785693728 8 Q13510,P25705 2 +Aplasia hypoplasia of the cerebral white matter 0.4468310319747167 0.6587483086987824 0.5100574058751142 1.0 0.9929913785693728 9 P00403 1 +Lower limb spasticity 0.3005568636901517 0.6569816252665037 0.5111927314251283 1.0 0.9929913785693728 78 P07602,O95831,P04062,P35637,Q9H6K4,P07942,P00846,P56589,Q96CU9,P46100,Q6DKK2,Q99720 12 +Congenital nystagmus 0.3781785229888654 0.6560544478715998 0.511789092057876 1.0 0.9929913785693728 17 P00846 1 +Waddling gait 0.3470369217388668 0.6555747685708745 0.5120977642969073 1.0 0.9929913785693728 25 Q8TD16,P02545,P07196,Q13510,P50402,P22626,Q4J6C6 7 +Synostosis of metacarpals metatarsals 0.716932484641388 0.6549522017513673 0.5124985290016202 1.0 0.9929913785693728 3 Q15233 1 +Abnormality of the nasal septum 0.4885045662796916 0.6547272025618364 0.5126434078592355 1.0 0.9929913785693728 6 P51812 1 +Prominent superficial blood vessels 0.3980780381795011 0.6537585172974584 0.513267396097761 1.0 0.9929913785693728 13 Q9Y487,P02545 2 +Abnormality of the foot musculature 0.7161429431673396 0.6523446677022506 0.5141788507852343 1.0 0.9929913785693728 3 O14979 1 +Abnormal number of permanent teeth 0.7261167264427734 0.6521042269190639 0.5143339374544078 1.0 0.9929913785693728 2 Q12959 1 +Menorrhagia 0.725790674926635 0.650970773448911 0.5150653535257499 1.0 0.9929913785693728 2 P35579 1 +Peripheral cyanosis 0.4635112982117055 0.6508298460460535 0.5151563315444596 1.0 0.9929913785693728 7 P51812,P04066 2 +Brain stem compression 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Ear pain 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Hypothalamic hypothyroidism 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Decreased circulating follicle stimulating hormone concentration 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Abnormal central sensory function 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Neuralgia 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Intracranial meningioma 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Transient global amnesia 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Decreased circulating gonadotropin concentration 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Progressive pulmonary function impairment 0.7153433376916255 0.649706816959292 0.5158816196920863 1.0 0.9929913785693728 3 Q969G3 1 +Abnormal circulating estrogen level 0.417721644417211 0.6477116373886368 0.5171714759410146 1.0 0.9929913785693728 11 P16435,Q969G3,P57740 3 +Childhood onset sensorineural hearing impairment 0.7241604173459517 0.645312662296962 0.5187245886691203 1.0 0.9929913785693728 2 Q9NSE4 1 +Prelingual sensorineural hearing impairment 0.7241604173459517 0.645312662296962 0.5187245886691203 1.0 0.9929913785693728 2 Q9NSE4 1 +Abnormal coronary artery morphology 0.4860698173160272 0.6441454353952615 0.5194811297880935 1.0 0.9929913785693728 6 P16278 1 +Hypochromic microcytic anemia 0.5563330173595299 0.6435329668041578 0.5198783305462975 1.0 0.9929913785693728 4 P46100 1 +Primary peritoneal carcinoma 0.5562805872756803 0.6433347490983704 0.5200069130862588 1.0 0.9929913785693728 4 O60934,Q92878,P49959 3 +Mildly elevated creatine kinase 0.3645337089411143 0.6423908405840184 0.520619445332382 1.0 0.993019947097062 20 P50570,Q92734,P02545,Q9BUK6,P06753,P43243,P39210,Q9BPX6 8 +Apraxia 0.309805546372783 0.6401247612234918 0.5220914922925068 1.0 0.993019947097062 59 Q9UGU0,P04062,P35637,Q9BVA1,Q00577,O43924,Q6DKK2,O14773,Q7LGA3,Q15233 10 +Abnormal heart valve morphology 0.2946525489899205 0.639106594199245 0.5227535904167377 1.0 0.993019947097062 73 Q15233,P04062,Q9H3P2,P55795,P53701,P02545,P06753,P37268,P16278,P61978,P21964,O60826,O75431,O75844,P51812,P46100,Q9UHX1 17 +Progressive inability to walk 0.3748466522956333 0.6344302998816995 0.5258000406713341 1.0 0.9933097414771302 17 Q15043,P21912,P00846 3 +Hypercholesterolemia 0.4152691666160443 0.634359659666444 0.5258461299223236 1.0 0.9933097414771302 11 Q15904,Q8N511,O75431,P02545 4 +Heterotaxy 0.5538346454740134 0.6341039209300979 0.5260130040874273 1.0 0.9933097414771302 4 Q9H3P2 1 +External ophthalmoplegia 0.3585895492587052 0.6320833327873673 0.5273324256152421 1.0 0.9933097414771302 21 P50570,P03915,Q13586,P21912,P00403,Q8N183,P16219,Q07021 8 +Abnormality of chromosome stability 0.4048811162940555 0.6314937726642345 0.527717719721803 1.0 0.9933097414771302 12 P33991 1 +Abnormal circulating free fatty acid concentration 0.5527320675075047 0.6299534459015423 0.5287250434396538 1.0 0.9933097414771302 4 O75431 1 +Abnormal fundus autofluorescence imaging 0.718617541571565 0.6261914731850607 0.5311893593837671 1.0 0.9933097414771302 2 Q8WWY3 1 +Scapular winging 0.3477590471910765 0.6249474856503476 0.5320055249826985 1.0 0.9933097414771302 23 Q8TD16,P02545,Q9Y487,P07196,P50402 5 +Truncus arteriosus 0.4133670848105851 0.6240342487313736 0.5326050930730162 1.0 0.9940011353760392 11 P21964 1 +Increased intracranial pressure 0.3695206586676477 0.6223851244248488 0.5336886594968997 1.0 0.9948201384233772 18 P07602,Q969G3 2 +Parkinsonism with favorable response to dopaminergic medication 0.439416958847823 0.621812531518043 0.5340651452356329 1.0 0.9948963154975188 9 P07602 1 +Open mouth 0.3445634073941752 0.6210557038309029 0.5345629729454571 1.0 0.9949608336483056 30 P04062,P61978,P51812,Q00577,P46100,Q86XL3,Q15233 7 +Hydranencephaly 0.7166612324747315 0.6194867785244305 0.5355957292426086 1.0 0.9951150038825934 2 Q92917 1 +Progressive spastic quadriplegia 0.4479511421800169 0.6187369913628311 0.5360896367420656 1.0 0.9956262857812656 8 P07602,O43681 2 +Anophthalmia 0.4259444373740061 0.6183242799055494 0.5363616000792657 1.0 0.995725123801312 10 P53701,Q8NAT1,O43505,O75569 4 +Ankle clonus 0.3802811359000831 0.6152021112740786 0.538421253673528 1.0 0.996043769321136 14 P07602 1 +Steroid resistant nephrotic syndrome 0.5005537094060561 0.6133930861151827 0.5396164565074932 1.0 0.996043769321136 5 Q8N1F7 1 +Abnormal protein glycosylation 0.3679821925548977 0.6122556061154887 0.5403686565797365 1.0 0.996043769321136 18 Q8N511 1 +Hydrocephalus 0.2949332714247282 0.6097212262730147 0.5420464911677381 1.0 0.996043769321136 76 P40855,P53701,Q969G3,Q10713,O60826,P21964,P07942,O00459,P23786,O43505,Q9Y5P6,Q8NAT1,Q8TAA9,Q15392,Q08J23,P16435,P04062,O96028 18 +Reduced subcutaneous adipose tissue 0.4369155765212016 0.6094292201888208 0.5422399746811948 1.0 0.996043769321136 9 O75844,P02545 2 +Abnormal large intestine physiology 0.3456372951893465 0.6092313287413537 0.5423711173217307 1.0 0.996043769321136 23 P07602,P21964 2 +Abnormal circulating carbohydrate concentration 0.3405339654878488 0.6079212575923869 0.5432396999992699 1.0 0.996043769321136 39 O95831,O43676,Q96CU9,Q9BWD1,Q70HW3 5 +Vertebral compression fracture 0.3738212997177949 0.607822070782934 0.5433054894632259 1.0 0.996043769321136 16 Q14108,Q32P28,Q96HY6 3 +Athetosis 0.3736792895816254 0.6069271535048757 0.5438992570375722 1.0 0.996043769321136 16 O14949,Q96CU9,O00584 3 +Abnormal metacarpal morphology 0.3419801580309248 0.604888403254903 0.5452531490507275 1.0 0.996043769321136 28 P51812,P16278,Q32P28,O43924 4 +Insulin resistant diabetes mellitus 0.4447464659918714 0.6034782437713015 0.5461905845328923 1.0 0.996043769321136 8 O75844,P02545 2 +Abnormal shoulder physiology 0.7011458213814239 0.6033806152555462 0.5462555148551245 1.0 0.996043769321136 3 P02545 1 +Chorea 0.3031481481853276 0.6033391113749842 0.5462831192229669 1.0 0.996043769321136 86 P07602,P35637,O43681,P03915,Q9H6K4,O14936,P00846,Q01105,Q96N66,Q9BWD1,Q08J23,Q99720,Q9BPX6 13 +Decreased calvarial ossification 0.545147174670366 0.6015865875713374 0.5474493590447618 1.0 0.996043769321136 4 O75844,P02545 2 +Cutaneous cyst 0.7002609262883192 0.6005265792115958 0.5481553526522169 1.0 0.996043769321136 3 O60716,Q8TAA9 2 +Retinal degeneration 0.3158533863251119 0.5986113228393068 0.5494321036594911 1.0 0.996043769321136 55 Q7Z4L5,Q96F07,P02545,O75503,P50897,Q13510,O14773,P68371,Q7LGA3,P04062 10 +Zonular cataract 0.4219977874275933 0.5979702646340236 0.5498597741239193 1.0 0.996043769321136 10 P08670 1 +Nephritis 0.3579995869893972 0.5973881790671562 0.5502482440945702 1.0 0.996043769321136 20 Q8N1F7,P35579,Q14C86,Q8NFH4,P57740,O43707,Q03252 7 +Noncompaction cardiomyopathy 0.6991688588407381 0.5970099768584953 0.5505007196087068 1.0 0.996043769321136 3 Q15233 1 +Intestinal malrotation 0.3393031478688849 0.5962465049894391 0.5510105623266881 1.0 0.996043769321136 25 P21964 1 +Sepsis 0.3391416301914096 0.595015967660333 0.5518327975613815 1.0 0.996043769321136 25 P00813 1 +Thyroid carcinoma 0.37429744229893 0.5936067702722841 0.5527751517357182 1.0 0.996043769321136 15 Q969G3,O14497,Q12824,P21912,Q92785 5 +Peroneal muscle atrophy 0.697446400934566 0.5914761776698623 0.5542014122349039 1.0 0.996043769321136 3 Q9NR77 1 +Poor wound healing 0.4950669323865438 0.5913024409328131 0.5543177943807069 1.0 0.996043769321136 5 O15269,P04062 2 +Tachycardia 0.3383980128669813 0.589355458681319 0.5556228491653812 1.0 0.996043769321136 25 P02545,O43772,P23786,P41227,P21912,P36551,P42892,Q8NFF5,Q14BN4 9 +Abnormality of complement system 0.5416566858623025 0.588645695286419 0.5560989737068165 1.0 0.996043769321136 4 P02545 1 +Abnormality of somatosensory evoked potentials 0.695789744917575 0.5861686642983933 0.5577621771756747 1.0 0.996043769321136 3 P20700 1 +Abnormality of the brainstem white matter 0.6952826618598611 0.5845470415688049 0.5588523257570697 1.0 0.996043769321136 3 P20700 1 +Tetraparesis 0.3396780244950943 0.5841376689741865 0.5591276932047888 1.0 0.996144524253698 35 P07602,Q9H9P8,P35637,P00846 4 +Cortical myoclonus 0.6940639269406343 0.5806552899636722 0.5614728005281355 1.0 0.998669418222023 3 P29992,O95394 2 +Hamartoma 0.3662956993704573 0.5794529912774172 0.5622835570421039 1.0 0.998669418222023 17 P21912,P48735,O43924 3 +Generalized onset seizure 0.3151871758765638 0.5768091041150285 0.5640684187604437 1.0 0.9994235200905142 103 P07602,P16278,O75503,Q14108,P61978,P03915,Q92796,O14936,P00846,Q13510,P51812,Q01105,Q96N66,Q00577,Q08J23,P04062 16 +Abnormality of the cerebrospinal fluid 0.3455717216952451 0.5764116321053518 0.5643369838759402 1.0 0.9994235200905142 143 Q9NR77,P20700,P21964,P39210,P00846,O96000,Q08J23,Q10713,P07602,P40855,O00459,Q96CU9,Q9Y5P6,Q8NI60,Q03252,Q16625,Q15392,O96028,O95831,O43676,Q8NAT1,P00403,Q8TAA9,P16435,P53701,Q969G3,O60826,P03915,P07942,P23786,O43505,P04062,O43681 33 +Large hands 0.404251039394364 0.5749423897178424 0.5653302600447958 1.0 1.0 11 P51812 1 +Tritanomaly 0.6916049227172628 0.572827754245138 0.5667613250540482 1.0 1.0 3 Q9H6K4 1 +Anomalous trichromacy 0.6916049227172628 0.572827754245138 0.5667613250540482 1.0 1.0 3 Q9H6K4 1 +Abnormal right ventricle morphology 0.4463294140238233 0.5719693398078495 0.5673427463338396 1.0 1.0 7 Q15233 1 +Contractures involving the joints of the feet 0.3542554448665428 0.5718301358406308 0.5674370588812647 1.0 1.0 20 P50402,Q8IZA0,Q08J23,P02545 4 +Recurrent paroxysmal headache 0.416565437614332 0.5701476858903045 0.5685775345567639 1.0 1.0 10 P03915,P00403 2 +Sporadic 0.3533859111548023 0.5659203656044153 0.5714479165108624 1.0 1.0 20 P51812,Q9BWD1,P04062,Q03252 4 +Central nervous system cyst 0.3207441030654502 0.5657946187681577 0.5715334050178622 1.0 1.0 51 Q969G3,O60826,Q9Y487,P23786,Q99567,O43505,P00846,Q9Y5P6,Q8NAT1,Q9NQT5,Q9UHX1,P07437 12 +Renal hypoplasia 0.3371867757325105 0.5648711011681379 0.5721614412500102 1.0 1.0 29 P21964,O43924,P46100 3 +Paraparesis 0.334375467527058 0.564496322854365 0.5724164019674296 1.0 1.0 24 P35637,Q9H6K4,Q13510,Q6DKK2,P04062 5 +Decreased cervical spine flexion due to contractures of posterior cervical muscles 0.4674747231938644 0.5644902618045622 0.5724205257272652 1.0 1.0 6 P50402,Q15149,P02545 3 +Coloboma 0.3309127914025446 0.5639704644362854 0.5727742330317329 1.0 1.0 44 P78318,Q96EK5,P53701,O60826,P61978,O14936,O96028,O43505,P41227,Q9Y5P6,Q8NAT1,O43924,Q9H3P2,Q10713,Q9UHX1 15 +Multiple gastric polyps 0.700032605151623 0.5634805037873218 0.573107732246041 1.0 1.0 2 P20585 1 +Epidermoid cyst 0.7000326051516133 0.5634805037872899 0.5731077322460627 1.0 1.0 2 O60716 1 +Muscle fiber inclusion bodies 0.4020821021411238 0.5633657032903263 0.5731858862791865 1.0 1.0 11 O43676,Q9Y5P6,P07196,P06753 4 +Eeg with spike wave complexes 0.3824397944698684 0.5627606785881045 0.5735978592925912 1.0 1.0 13 Q14108 1 +Elevated urinary carboxylic acid 0.4667635248820584 0.5614884701828735 0.5744645881174257 1.0 1.0 6 P36551,O96000 2 +Vocal cord paralysis 0.356458984941676 0.5603600086830406 0.5752339035641847 1.0 1.0 19 Q9NR77,P50402,P02545 3 +Hyperventilation 0.435397637620222 0.5593677963900227 0.5759107347692192 1.0 1.0 8 P03915,P00846 2 +Ependymoma 0.687210386149605 0.5589230125951685 0.5762142631627742 1.0 1.0 3 O75874 1 +Decreased circulating copper concentration 0.6984023475709112 0.5580891642957527 0.5767834994370078 1.0 1.0 2 Q15904 1 +Asymmetry of the ears 0.6867343263076919 0.5574232955785465 0.5772382527753446 1.0 1.0 3 Q9UHX1 1 +Hypertrophic cardiomyopathy 0.3148679173399296 0.5534762609195701 0.5799373316254071 1.0 1.0 105 P53701,Q9H061,P54802,P16278,P03915,P00846,O43676,Q96CU9,O96000,Q13423,P00403 11 +Ventricular escape rhythm 0.4854376436369289 0.553005476545166 0.5802596600883603 1.0 1.0 5 P02545 1 +Lymphoma 0.3341018723479701 0.5518373281497292 0.581059810009207 1.0 1.0 26 P00813,P46100 2 +Median cleft palate 0.6964460384740736 0.5516441332749306 0.5811921929941566 1.0 1.0 2 Q14739 1 +Prominent ear helix 0.5312299446210751 0.5504450245863967 0.5820141740446727 1.0 1.0 4 P02545 1 +Functional motor deficit 0.3405358702420746 0.5502496860738947 0.5821481287275889 1.0 1.0 139 Q9NR77,P04062,Q8TD16,P00846,Q9BPX6,P07602,P35637,Q15067,Q13510,Q8NI60,Q9Y2R0,P50570,P00403,O14773,Q9NWM8,P35670,P53701,Q969G3,Q96F07,P61978,P03915,P07196,P23786,Q99720,O43681 25 +Abnormal circulating proteinogenic amino acid derivative concentration 0.3468389022183107 0.5498362868051115 0.5824316675000596 1.0 1.0 21 P25705,P03915,P00846,P22695,O96000 5 +Limb dystonia 0.3901346654373922 0.5493554550094614 0.5827615374025088 1.0 1.0 12 Q99720,P35637 2 +Sarcoma 0.3087355022039104 0.5485084301759928 0.5833428423589904 1.0 1.0 56 Q969G3,Q13126,Q15392,Q92804,P02545,Q07954,P48735,P21912,P46783,Q01844 10 +Short ribs 0.4326604286093882 0.5465751298539286 0.5846706591617681 1.0 1.0 8 Q96HY6 1 +Abnormal endocrine physiology 0.4627490345007914 0.5446122338951556 0.5860202388669848 1.0 1.0 6 Q13423,P16435 2 +Thickened nuchal skin fold 0.398349754605755 0.5435453329325027 0.5867543872619614 1.0 1.0 11 P61978,P40855,O75381,P56589 4 +Hypoplastic fifth toenail 0.4318283138722337 0.5426977976043017 0.5873378908684557 1.0 1.0 8 O14497,Q969G3,Q92785 3 +Abnormality of the umbilical cord 0.4315801823347291 0.5415426709332829 0.588133594443013 1.0 1.0 8 O75844,P16435,P02545 3 +Cerebral inclusion bodies 0.3976961513753543 0.5400880267893385 0.5891363274311301 1.0 1.0 11 O15118,P22626 2 +Cervical spinal canal stenosis 0.6928594717965609 0.5398990254948975 0.5892666699838887 1.0 1.0 2 Q9NSE4 1 +Simplified gyral pattern 0.3335249153426892 0.5394571446317152 0.5895714598968402 1.0 1.0 28 Q5KU26,Q969G3,P20700,O14936,Q9UPT5,Q03252,Q86XL3 7 +Chromosome breakage 0.4225827352324669 0.5393379267281739 0.5896537035924045 1.0 1.0 9 P33991 1 +Misalignment of incisors 0.4612757653092201 0.5384485296001041 0.5902674301710373 1.0 1.0 6 P46100 1 +Aplasia hypoplasia involving the sinuses 0.4813528529228578 0.5369546737540957 0.591298923584872 1.0 1.0 5 P46100 1 +Long palpebral fissure 0.3310584240682965 0.5339370748174126 0.5933850703173595 1.0 1.0 25 Q5KU26,P20700,P61978,Q92796,O00459,P51812,Q00577,Q01082 8 +Abnormally large globe 0.4295154280416492 0.5319499608367055 0.5947606530654153 1.0 1.0 8 O14936,O75431 2 +Glomerulonephritis 0.3586272878103194 0.5308731988288448 0.5955066512412353 1.0 1.0 17 Q8N1F7,Q14C86,Q8NFH4,P57740,O43707,Q03252 6 +Fatty replacement of skeletal muscle 0.4367896116468465 0.529063172271821 0.5967616278423737 1.0 1.0 7 P51114,P22626 2 +Ineffective esophageal peristalsis 0.4589485423898116 0.5287456072597068 0.5969819346770009 1.0 1.0 6 Q9NSE4 1 +Fragile nails 0.3861933185563867 0.527754901038972 0.5976694626353867 1.0 1.0 12 Q9Y487 1 +Limited elbow movement 0.332939696652566 0.5270359672739715 0.5981686117571428 1.0 1.0 33 P37268,P02545,P06753,Q9H6K4,P23786,P50402,Q7LGA3,P16435 8 +Motor axonal neuropathy 0.3654881936659047 0.5264645186179123 0.5985654982655686 1.0 1.0 14 O95831 1 +Gastrointestinal hemorrhage 0.3317533787313552 0.5258950411318506 0.598961134546423 1.0 1.0 28 P21964,Q9UHX1,P46100 3 +Calcification of the aorta 0.5241787600972121 0.5250255069097337 0.5995654595062214 1.0 1.0 4 P04062 1 +Skin appendage neoplasm 0.5235442693405894 0.5227554825468436 0.6011444227081426 1.0 1.0 4 P25054,P43246 2 +Abnormality of the ureter 0.3015056550315692 0.5223943277644573 0.6013958045345942 1.0 1.0 58 P16435,P02545,P61978,P21964,O14936,P09471,P23786,P41227,P21912,O75844,P46100,Q8TAA9,Q86XL3,Q7LGA3,Q9UHX1 15 +Impacted tooth 0.6752081482659726 0.5215210388950573 0.6020038533130871 1.0 1.0 3 P02545 1 +Mottled pigmentation 0.6752081482659726 0.5215210388950573 0.6020038533130871 1.0 1.0 3 P02545 1 +Limitation of movement at ankles 0.6752081482659726 0.5215210388950573 0.6020038533130871 1.0 1.0 3 P02545 1 +Unilateral renal agenesis 0.3567440896617424 0.5190600717719671 0.6037188510216231 1.0 1.0 17 Q86XL3,Q7LGA3,Q9UHX1 3 +Abnormality of the bladder 0.3142698934776398 0.5175174355220546 0.6047950009193896 1.0 1.0 108 Q9NR77,P21964,P46100,Q9UHX1,P07602,P35637,Q92796,P50570,P56589,P51812,P22626,Q9NWM8,Q969G3,P61978,P07196,Q99720,Q86XL3,P04062,O43681 19 +Duplication of hand bones 0.3157272223614398 0.5172630123186757 0.6049725702910882 1.0 1.0 51 Q7Z4L5,Q10713,P46783,O60826,P61313,P21964,Q15067,O00459,P57740,P41227,P98175,O43924,Q9H3P2,P98172,Q9UHX1,O96028 16 +Abnormality of humoral immunity 0.3008372829876334 0.5153055373007956 0.606339530146784 1.0 1.0 58 P28070,P14174,P02545,Q14108,P09601,P00813,Q03252,P04062 8 +Symphalangism affecting the phalanges of the hand 0.6729005087774376 0.5144304945919866 0.6069510434941969 1.0 1.0 3 Q15233 1 +Proximal symphalangism 0.6729005087774376 0.5144304945919866 0.6069510434941969 1.0 1.0 3 Q15233 1 +Entropion 0.40546501241731 0.5140717537315436 0.6072018249396796 1.0 1.0 10 P02545 1 +Shawl scrotum 0.45487638505963 0.5118691258489831 0.6087426072820399 1.0 1.0 6 P46100 1 +Attenuation of retinal blood vessels 0.4546011690042282 0.510733316778989 0.6095378080739173 1.0 1.0 6 P50213,O43837,P04439 3 +Thickened calvaria 0.4165345142567611 0.5102556350126782 0.6098723797334038 1.0 1.0 9 P51812,P16278 2 +Vomiting 0.3055245663151807 0.510152169541187 0.6099448584231661 1.0 1.0 98 P07602,P61978,P03915,P39210,P00846,O43676,Q96CU9,O96000,Q13423,P00403,P46100,Q9Y584,P11117 13 +Abnormality of the extraocular muscles 0.6709067188519046 0.5083314122396179 0.611220944267211 1.0 1.0 3 P43243,Q9BVA1 2 +Brittle hair 0.354420895336925 0.5045551232987057 0.6138713363360566 1.0 1.0 17 Q9Y487 1 +Abnormality of lower limb epiphysis morphology 0.3595790159355774 0.5042491338718833 0.6140863170753157 1.0 1.0 15 O95831,Q7LGA3 2 +Abnormality of the proximal phalanx of the thumb 0.6817737202478167 0.5041970512119393 0.6141229123913325 1.0 1.0 2 Q15233 1 +Symphalangism of middle phalanx of finger 0.6817737202478167 0.5041970512119393 0.6141229123913325 1.0 1.0 2 Q15233 1 +Focal onset seizure 0.291338729015516 0.5025115241367246 0.6153077480836311 1.0 1.0 82 P07602,Q969G3,O75503,P03915,Q9BVA1,O14936,Q9UPT5,Q01105,Q96N66,Q00577,P00403,Q08J23,Q9UBX3 13 +Large placenta 0.6689094129248734 0.5022471323733048 0.615493692558321 1.0 1.0 3 P02545 1 +Fetal distress 0.3267046974308348 0.5014884102524138 0.6160274324348629 1.0 1.0 25 O43676,Q96CU9 2 +Abnormal paranasal sinus morphology 0.3258294725254949 0.5009564991635703 0.6164017381984559 1.0 1.0 24 P00813,Q03519,P46100 3 +Ectopic calcification 0.2994439825417532 0.5005657890758132 0.6166767443872965 1.0 1.0 58 P35670,O00584,P02545,O75381,P03915,P23786,O75431,P56589,O75844,P00403,Q16625,P04062 12 +Childhood onset 0.3287241907108753 0.4997345884643421 0.6172619742487035 1.0 1.0 37 Q9NR77,P22830,Q14566,O75431,P50402 5 +Very long chain fatty acid accumulation 0.4517956565671357 0.4991905460528306 0.6176451540814607 1.0 1.0 6 O75381,P56589 2 +Hepatoblastoma 0.4024600728057043 0.4990893393659875 0.6177164474372239 1.0 1.0 10 Q969G3,O14497,Q12824,Q92785,P25054 5 +Sleep apnea 0.3393945219777917 0.498736078354895 0.6179653244599472 1.0 1.0 21 Q93009,P51114,Q16531,Q96A33,P51812,Q15233 6 +Abnormal circulating dicarboxylic acid concentration 0.3262819942187053 0.4985747281200625 0.6180790124099906 1.0 1.0 41 P40855,P37268,P41440,O14936,P23786,P22695,P36551,Q9H9P8,P55263,P48735,Q01082 11 +Anterior uveitis 0.6668924603364841 0.4961293080055108 0.6198031825889154 1.0 1.0 3 P14174 1 +Abnormal atrioventricular valve physiology 0.3241652451681387 0.4951879234043399 0.6204674744875815 1.0 1.0 43 P53701,P04062,P02545,Q15904,P06280,O00459,O75431,O75306,O75844,P51812,P46100,Q15233 12 +Abnormal sella turcica morphology 0.4291375227871147 0.4951747927593306 0.6204767423723259 1.0 1.0 7 P16278 1 +Dermal translucency 0.4291010103310965 0.4950143017087865 0.6205900251921737 1.0 1.0 7 P02545 1 +Moderate sensorineural hearing impairment 0.4131542837356829 0.4941451596091532 0.6212036665816878 1.0 1.0 9 P51812 1 +Constipation 0.2923641914579036 0.4941028976601096 0.6212335115571928 1.0 1.0 84 Q9UGU0,P78318,P20700,P21964,P49366,P21912,P42892,P46100,Q7LGA3,O00592,P36551,Q03252,P50336,P55795,Q13423,P00403,Q03164,Q8TAA9,P16435,P37268,P61978,P03915,P04062 23 +Vascular neoplasm 0.3285585264482251 0.4923393333057422 0.6224794786096322 1.0 1.0 33 P50570,P16435,O60826,P21912,Q9H3P2,P10619,P48735,Q7LGA3,Q9UHX1 9 +Multifocal epileptiform discharges 0.3272963462601057 0.4920246214657867 0.6227019379891892 1.0 1.0 28 O75503,O14936,P09471,Q96N66,Q08J23,Q9UBX3 6 +Abnormality of the ribs 0.2961400060239594 0.4916070042372943 0.6229971909657874 1.0 1.0 59 P50570,Q7Z4L5,O95831,Q32P28,P54802,P16278,P02545,O75431,P00813,O75844,Q96HY6,Q9UHX1 12 +Brain imaging abnormality 0.3283346814240597 0.4908892234979657 0.6235047994356568 1.0 1.0 34 P07602,Q969G3,P03915,Q00577,P00403 5 +Coronary artery atherosclerosis 0.5134669041461494 0.4871056209012727 0.6261834832978543 1.0 1.0 4 P02545 1 +Thoracic hypoplasia 0.3273525894662836 0.48651985331141 0.6265986326841855 1.0 1.0 30 Q7Z4L5,P04062,Q14739,P02545,P06753,Q92796,Q96A33,P41227,Q96HY6,P16435,Q9UHX1 11 +Eyelid myoclonus 0.3994700316513336 0.4842718350452021 0.6281929617210089 1.0 1.0 10 Q13510,P00374,Q01105 3 +Diffuse cerebral atrophy 0.3558904750735533 0.4822949002997118 0.6295964694905274 1.0 1.0 15 P07602,O14936,P16278,Q10713 4 +Adenocarcinoma of the small intestine 0.6621004566209864 0.4817022410394314 0.630017483856129 1.0 1.0 3 P25054,P78549 2 +Duodenal adenocarcinoma 0.6621004566209864 0.4817022410394314 0.630017483856129 1.0 1.0 3 P25054,P78549 2 +Abnormal pulmonary valve morphology 0.3531426642380185 0.4800392776483521 0.6311994643324621 1.0 1.0 16 P21964 1 +Abnormality of the 2nd toe 0.3982695988889865 0.4783492415500308 0.6324016543103572 1.0 1.0 10 P51812 1 +Brushfield spots 0.5108523686629537 0.4779854666141351 0.6326605491623156 1.0 1.0 4 O75381,P56589 2 +Coxa valga 0.3359130839324771 0.4751487933670984 0.634680922363072 1.0 1.0 21 P16278,P02545,P51812,O75844,P46100 5 +Proximal muscle weakness in lower limbs 0.346674371826642 0.4749890824345545 0.6347947549585338 1.0 1.0 18 P35670,P50570,P07196,P02545 4 +Abnormal insulin level 0.3270685799271815 0.4745247408888033 0.6351257594515118 1.0 1.0 23 O75844,P02545,P53985 3 +Abnormal response to endocrine stimulation test 0.5098232189063691 0.4744106932288975 0.635207069147399 1.0 1.0 4 Q13423 1 +Abnormal urine cytology 0.3261372152274598 0.4744026134119755 0.6352128297784438 1.0 1.0 35 Q8N1F7,Q14108,P09601,P06280,P21912,Q03252,O15460,Q01082,P04062 9 +Slow saccadic eye movements 0.3974299044344052 0.4742155901959579 0.6353461770571376 1.0 1.0 10 Q8IV08 1 +Shortening of all distal phalanges of the fingers 0.3850538777992137 0.4740863888288453 0.6354383043500227 1.0 1.0 11 P51812,Q92796 2 +Emotional lability 0.3056443166524179 0.4737984539612119 0.6356436371825325 1.0 1.0 54 P07602,Q969G3,Q92804,P35637,Q96CU9,Q15165,Q96CV9,O43681 8 +Progressive spastic paraplegia 0.3247568403825726 0.4728967234007733 0.636286862715058 1.0 1.0 28 P00846 1 +Death in infancy 0.2991242261689459 0.4726801302353454 0.6364414045719053 1.0 1.0 57 O43819,P51114,P02545,O75718,P46100,Q6PJG6,P07602,P40855,Q9Y5S9,Q15904,O75381,Q15067,Q5JTZ9,P50570,P56589,Q9BT22,Q15149,P16278,O60826,P04062 20 +Generalized amyotrophy 0.3234967523985979 0.4723888222779291 0.636649281291449 1.0 1.0 26 P35637,P02545,P06753,Q99567,Q9Y5P6,Q03252,P22626 7 +Short columella 0.6713400717313373 0.47147104464577 0.6373043923783264 1.0 1.0 2 P41227 1 +Abnormality of the nasal bone 0.5086460032626262 0.4703322503468446 0.6381176596261757 1.0 1.0 4 Q6NUK1,O14974,P35222 3 +Poor gross motor coordination 0.6577864275577867 0.4688473987070334 0.6391787172144454 1.0 1.0 3 O75503 1 +Acute phase response 0.3220731556748309 0.4673581962755877 0.6402436260088344 1.0 1.0 25 P28070,P14174,O15460,P41440 4 +Ulnar deviation of the wrist 0.6572179944164991 0.4671631985017218 0.6403831212530284 1.0 1.0 3 P16278 1 +Exodeviation 0.3211366615819894 0.4666283207189155 0.6407658211374059 1.0 1.0 24 P55795,P46100,Q9UEY8,P98172,Q15233,Q9UHX1 6 +Cystic hygroma 0.4224095959432005 0.4658076917908532 0.6413531588902075 1.0 1.0 7 P61978,Q99567 2 +Bulbar palsy 0.395575643053433 0.465114615177158 0.6418493802592575 1.0 1.0 10 O43681,P35637,P06753 3 +Macular atrophy 0.443318069619177 0.464721028231737 0.6421312475470027 1.0 1.0 6 P04062,P04439 2 +Retinal detachment 0.3527291888918639 0.4636366821115644 0.6429080686119562 1.0 1.0 15 Q9Y5P6,Q8NAT1,O43505,P04439 4 +Cervical ribs 0.655078649042991 0.4608449083696273 0.6449098795887096 1.0 1.0 3 Q9UHX1 1 +Abnormal morphology of the conjunctival vasculature 0.4138424857014644 0.4603544832711994 0.6452618000410464 1.0 1.0 8 P10619,P06280 2 +Paranoia 0.4610756217678796 0.4592140855075533 0.6460804365862041 1.0 1.0 5 P36551,P50336 2 +Infantile axial hypotonia 0.373216109589581 0.4578782730766519 0.6470398971727949 1.0 1.0 12 P07602 1 +Aplasia hypoplasia of the clavicles 0.373083403825743 0.4571744527266415 0.647545659365341 1.0 1.0 12 P41227,O75431,P02545,O75844 4 +Thick corpus callosum 0.6531940795045108 0.4553059408611304 0.6488891528422818 1.0 1.0 3 Q15233 1 +Abnormal sternal ossification 0.6530863691304956 0.4549901344825172 0.6491163363456618 1.0 1.0 3 O96028 1 +Congenital contracture 0.3215549045308438 0.4529696515569203 0.6505705949138225 1.0 1.0 40 P50570,Q8TD16,P02545,Q99567,Q96A33,Q9UPT5,O75844,Q15392,P04062 9 +Resting tremor 0.3460192731651222 0.4527761321870036 0.6507099519615545 1.0 1.0 17 P07602,Q9H6K4,Q9BPX6 3 +Lateral clavicle hook 0.6651450929246794 0.4524652937175282 0.6509338183235873 1.0 1.0 2 Q9Y5S9 1 +Pectus excavatum 0.2818090817717444 0.4514945235620208 0.6516331711882666 1.0 1.0 76 P78318,P02545,Q9BUK6,Q96A33,P41227,P21912,P98175,Q08J23,Q7LGA3,Q9UHX1,P07437,Q9Y487,P06753,O75431,P51812,Q03164,P61978,P50402,P04062 19 +Tented upper lip vermilion 0.3322942058277108 0.4508595749933721 0.6520907605859676 1.0 1.0 21 Q9UGU0,Q00577,Q96F07,P46100 4 +Urinary incontinence 0.3204490053967055 0.4492517459606723 0.6532500628815667 1.0 1.0 41 P50570,P07602,Q969G3,P35637,Q92796,P07196,P51812,Q99720 8 +Hiatus hernia 0.4582779206027093 0.4487648298759638 0.6536013121773414 1.0 1.0 5 Q8NBU5 1 +Loss of eyelashes 0.6504377942051847 0.4472508556591437 0.6546939460544519 1.0 1.0 3 P02545 1 +Cirrhosis 0.321755421946696 0.4461460178851791 0.6554917737487618 1.0 1.0 38 P35670,Q14108,P22830,P39210 4 +Abnormal facial expression 0.3223426573742737 0.4446175023701537 0.6565961968584682 1.0 1.0 32 Q9NR77,P50570,Q9BUK6,Q15043,P06753,Q00577,P04062,O00592 8 +Lower limb muscle weakness 0.3171225353018174 0.442518936002477 0.6581137307036626 1.0 1.0 44 Q9NR77,Q13510,P07196,P00846 4 +Abnormal meningeal morphology 0.3307310758774513 0.4404442470237247 0.6596153840888062 1.0 1.0 21 Q15904,P21964,Q9Y5P6,Q10713,Q9UHX1 5 +Abnormal magnesium concentration 0.4372451191872922 0.4404315757346392 0.6596245597513459 1.0 1.0 6 P53680,P61457 2 +Hydroureter 0.3903782944110474 0.4398119484363562 0.660073313017095 1.0 1.0 10 P41227,Q7LGA3 2 +Abnormality of metacarpophalangeal joint 0.4996562432283632 0.4395734221524466 0.6602460937457253 1.0 1.0 4 Q15233 1 +Impairment of activities of daily living 0.3000791276210847 0.4385910639074666 0.660957873165867 1.0 1.0 55 P50570,P07602,Q969G3,P35637,P21964,Q92796,P07196,P51812,Q99720 9 +Everted upper lip vermilion 0.4992448650385396 0.4381826767916121 0.6612538652335593 1.0 1.0 4 P04062 1 +Arthrogryposis multiplex congenita 0.3216012596197102 0.4378884228548933 0.6614671683418711 1.0 1.0 34 Q8TD16,P02545,Q99567,Q9UPT5,O75844,Q15392,P04062 7 +Cavernous hemangioma 0.4988849266856849 0.4369670712142521 0.6621352289287117 1.0 1.0 4 P50570 1 +Obstructive sleep apnea 0.3686509804283511 0.4338024393212168 0.6644319100955802 1.0 1.0 12 Q15233,P51114,Q96A33 3 +Abnormal ileum morphology 0.359296028617808 0.4330259711521385 0.6649959022491185 1.0 1.0 13 P51812 1 +Metaphyseal widening 0.3398533835067663 0.4324805026200183 0.665392219913542 1.0 1.0 18 O95831,P16278 2 +Absent nipple 0.6582980110857478 0.4318448561605673 0.6658541755540937 1.0 1.0 2 P10586 1 +Upper eyelid coloboma 0.6582980110857464 0.4318448561605633 0.6658541755540965 1.0 1.0 2 Q13428 1 +Abnormal aortic valve morphology 0.3193854506524269 0.4269589462012994 0.6694092300200161 1.0 1.0 38 P37268,P04062,P02545,P61978,P21964,P06280,O75844,P51812,Q9UHX1 9 +Eruption failure 0.4132021445549979 0.4263309285741468 0.6698667240875087 1.0 1.0 7 P02545 1 +Abnormal cartilage morphology 0.3746757953462692 0.4212956232788782 0.6735392257920334 1.0 1.0 11 P48735,Q7LGA3 2 +Chronic diarrhea 0.327811434000066 0.42111921726799 0.6736680294249522 1.0 1.0 21 P00813,Q08J23,Q96A33,Q13510 4 +Abnormal venous morphology 0.3171671877982506 0.420979425022965 0.6737701061500749 1.0 1.0 27 P98175,Q9Y487,P21964,P02545 4 +Multifocal cerebral white matter abnormalities 0.4506580289345119 0.4206793667505299 0.6739892299028298 1.0 1.0 5 P10253 1 +Dysmetria 0.2979905976257124 0.4179071480748919 0.6760150060934185 1.0 1.0 55 P41440,Q8IV08,O75503,O75027,O14773,Q6DKK2 6 +Chronic axonal neuropathy 0.6534072383436549 0.4173724719525226 0.6764059868398455 1.0 1.0 2 O15269 1 +Abnormal pulmonary interstitial morphology 0.3177806854612981 0.4172735958278941 0.6764782993532252 1.0 1.0 29 Q14108,Q8IZA0,P09601,Q13510 4 +Abnormality of canine 0.6524290837952362 0.4145042373036753 0.6785048644742269 1.0 1.0 2 P25054 1 +Posteriorly rotated ears 0.2997233425708073 0.4128092988366694 0.6797463380290782 1.0 1.0 101 Q9UGU0,Q99567,P41227,P98175,O43924,P42892,P46100,Q08J23,Q7LGA3,Q9UHX1,P07437,P40855,Q13868,O75381,Q14004,Q15392,Q4J6C6,P56589,Q8NAT1,Q9H3P2,P16435,P37268,P23786,O43505,P04062 25 +Cutis marmorata 0.3418198719178349 0.4126750063759121 0.6798447389899622 1.0 1.0 16 P51812 1 +Hypochromic anemia 0.3551287314752936 0.4104489409423453 0.6814766512523882 1.0 1.0 13 P46100 1 +Fatiguable weakness of proximal limb muscles 0.447693130738833 0.4099053576323503 0.6818753750614308 1.0 1.0 5 Q13586,P06753 2 +Abnormal sternum morphology 0.3018465119362281 0.4091720001370982 0.6824134409177363 1.0 1.0 104 P78318,Q7Z4L5,P02545,Q9BUK6,Q96A33,P41227,P21912,P98175,P98172,Q08J23,Q7LGA3,Q9UHX1,P07437,P17480,Q9Y487,Q13510,O96028,O95831,P55795,P06753,P57740,O75431,P51812,Q03164,P16278,P61978,P50402,P04062 28 +Tissue ischemia 0.3329646571156962 0.4088843565155056 0.6826245297198466 1.0 1.0 19 O75844,O15460,P02545 3 +Joint hemorrhage 0.6504727746983988 0.4087943720692878 0.6826905703835993 1.0 1.0 2 P49257 1 +Wide cranial sutures 0.4086566455726994 0.407170491908238 0.6838827725654699 1.0 1.0 7 P98175,P02545 2 +Hip contracture 0.3717526710451068 0.4066810511369239 0.6842422594894035 1.0 1.0 11 Q8TD16,Q7LGA3 2 +Papillary renal cell carcinoma 0.4463750180164669 0.4051442098538551 0.6853715112204617 1.0 1.0 5 P02545 1 +Diaphyseal thickening 0.6355674726905156 0.404771759040565 0.6856452893801226 1.0 1.0 3 Q14739 1 +Renal dysplasia 0.3628764532899772 0.4037687607289534 0.686382770505662 1.0 1.0 12 O43819,O14936,P09471,O43505,O75306 5 +Absent septum pellucidum 0.3171131598596963 0.4036148083189267 0.6864959945610858 1.0 1.0 33 P53701,Q15392,Q08J23 3 +Spinal muscular atrophy 0.3710418266562055 0.4031450644507723 0.686841510418067 1.0 1.0 11 Q99720,Q13510 2 +Abnormal anterior horn cell morphology 0.4271316979676758 0.4007937653209855 0.6885719695120662 1.0 1.0 6 Q92734,Q16637,Q13510 3 +Pulmonary fibrosis 0.331580139362027 0.4002615431048984 0.6889638898259012 1.0 1.0 19 P14174,P09601,Q8IZA0 3 +Generalized limb muscle atrophy 0.3999176368456888 0.3988111930541748 0.6900323289923744 1.0 1.0 8 Q9Y5P6,P06753 2 +Abnormal size of the palpebral fissures 0.2838738204559669 0.3940441769773801 0.6935484237973011 1.0 1.0 84 Q5KU26,Q9UGU0,P55795,P02545,Q13868,P61978,Q92796,P51812,P38159,P98175,O75844,Q00577,Q03164,Q14004,Q08J23,Q7LGA3,Q9UHX1,P07437 18 +Premature skin wrinkling 0.3305399371848415 0.3938086644600038 0.6937223069778036 1.0 1.0 19 Q9Y487,P02545 2 +Brisk reflexes 0.3150462299138958 0.3907085542565738 0.6960126751088695 1.0 1.0 23 P35637,Q10713,Q5JRX3,Q8NI60,Q99720 5 +Slender build 0.3601358711741604 0.389689056299391 0.696766489855043 1.0 1.0 12 Q15233,P06753 2 +Abnormal jejunum morphology 0.6436256928594702 0.3890938933114609 0.6972066906926317 1.0 1.0 2 P49454 1 +Abnormality on pulmonary function testing 0.3259112749562348 0.3853750059959647 0.6999595976060689 1.0 1.0 20 Q969G3,P16278,Q9BQT8 3 +Low frustration tolerance 0.3894921659321657 0.3846973470866808 0.7004616609426062 1.0 1.0 9 Q9UHX1,Q03164 2 +Emg slow motor conduction 0.64199543527877 0.3844695708151979 0.7006304450300189 1.0 1.0 2 O15269 1 +Penetrating foot ulcers 0.64199543527877 0.3844695708151979 0.7006304450300189 1.0 1.0 2 O15269 1 +Trophic changes related to pain 0.64199543527877 0.3844695708151979 0.7006304450300189 1.0 1.0 2 O15269 1 +Epiretinal membrane 0.6272015655577121 0.3816354813360422 0.7027317623791112 1.0 1.0 3 P25054,P04439 2 +Abnormality of the metaphysis 0.3076187392472382 0.3782778187873574 0.7052242213939213 1.0 1.0 46 O95831,Q13126,P16278,P00813,Q96HY6,P48735 6 +Absent facial hair 0.3773144121621733 0.3776796414464791 0.7056685933457181 1.0 1.0 10 Q07954,P02545 2 +Scrotal hypoplasia 0.3332441044566923 0.3763564510545351 0.7066519170262309 1.0 1.0 17 P46977,Q8TCJ2,P07437,P46100 4 +Long toe 0.3769423888054649 0.3759434792958996 0.706958915707703 1.0 1.0 10 P23786 1 +Oligosacchariduria 0.4800418198264682 0.3750238300089406 0.7076427441133177 1.0 1.0 4 P10253,P16278 2 +Abnormal brain positron emission tomography 0.4800278733230196 0.3749792740836093 0.7076758807896222 1.0 1.0 4 Q969G3 1 +Cortical dysplasia 0.3122526859758282 0.3733161377704796 0.7089131670236652 1.0 1.0 30 Q13885,Q9BVA1,O43505,Q96N66,Q08J23,P07437 6 +Ophthalmoparesis 0.2730219556702477 0.3691874682723429 0.7119879960054509 1.0 1.0 74 O43819,Q9Y4W6,Q13586,P00846,P21912,P16219,O15460,O43172,Q10713,Q9BPX6,Q9UNE7,Q96CU9,Q07021,P50570,P06753,Q12824,Q86U42,P00403,Q8N183,Q15149,Q969G3,P03915,O75306,Q8WWY3,P04062 25 +Abnormal nasal base 0.3640748902381051 0.3688785338024577 0.7122182643049966 1.0 1.0 11 O14497,Q969G3,Q92785,Q13868 4 +Abnormal mitral valve physiology 0.3121622364506498 0.3677119515692145 0.7130880279393932 1.0 1.0 32 P53701,P02545,P06280,O75431,O00459,O75306,P51812,O75844,P04062 9 +Increased susceptibility to fractures 0.2997099684096206 0.3665971776044227 0.7139195138106298 1.0 1.0 51 P35670,Q13126,Q32P28,P06753,Q14108,P39210,Q9H4A3,P48735,P22626,P04062 10 +Broad based gait 0.3193841904151214 0.366352799527771 0.7141018356014186 1.0 1.0 21 Q00577,O14773,P98175,Q03164 4 +Fetal ultrasound soft marker 0.3337203928060318 0.3658832610649193 0.7144521873520622 1.0 1.0 16 P40855,O60826,P61978,O75381,P56589,P16435 6 +Cranial hyperostosis 0.3466162429438303 0.365210416865619 0.7149543430296512 1.0 1.0 13 Q15043,P51812 2 +Vascular calcification 0.4347503303593438 0.3639541531525598 0.7158922453023426 1.0 1.0 5 P04062 1 +Vitritis 0.6204430805615111 0.3633671871791101 0.7163306098850137 1.0 1.0 3 P53701 1 +Type i diabetes mellitus 0.3547038410305013 0.3621342111828751 0.7172517393465703 1.0 1.0 12 P03915,P00403 2 +Hyperlordosis 0.3020710166961108 0.3617216272000905 0.7175600637576935 1.0 1.0 49 P50570,Q8TD16,P55795,P02545,P06753,P16278,P41227,P50402,Q9Y5P6,Q9NSE4,Q96HY6,Q9H4A3,P22626 13 +Abnormal palmar dermatoglyphics 0.2939145067560362 0.3597656771204188 0.7190223725730756 1.0 1.0 54 P40855,P61978,Q9Y487,O75381,Q99567,O75431,P57740,P56589,P41227,P51812,P98175,Q8WVM7,Q9UHX1,O96028 14 +Apnea 0.2774356263251085 0.3595049869884505 0.7192173477645034 1.0 1.0 80 P07602,P04062,O43772,P25705,P03915,P23786,P00846,Q96CU9,P51812,P98175,Q00577,O43924,Q15233 13 +Cholangitis 0.632213889794583 0.3572747304811208 0.7208861454625668 1.0 1.0 2 Q96J02 1 +Wide anterior fontanel 0.3138839209052156 0.355259414361354 0.722395257544274 1.0 1.0 22 P40855,Q32P28,O75381,Q9Y487,P56589,Q08J23 6 +Hypopigmentation of the skin 0.3081872989943357 0.3534520038902524 0.7237496049053642 1.0 1.0 42 P07602,Q8IZA0,P21964,P53701 4 +Restlessness 0.309403478582189 0.3504245286296231 0.7260201207862804 1.0 1.0 39 Q96CV9,Q92804,P35637,O96008,P35610,Q15165,P42892,P50995,P48449,Q01082,P04062,O00592 12 +Abnormality of bladder morphology 0.3811016837528499 0.3475042306142175 0.7282125407440483 1.0 1.0 9 Q9NWM8 1 +Prominent supraorbital ridges 0.3593227720756733 0.3459321873157938 0.7293936783367763 1.0 1.0 11 P51812 1 +Osteolysis 0.3066567678412924 0.3456825792023144 0.7295812778447459 1.0 1.0 27 P02545,Q14108,O75431,O75844,P48735,P22626,P04062 7 +Retinal fold 0.6269970655363497 0.3431669782306739 0.7314728454967832 1.0 1.0 2 P52732 1 +Abnormal urinary electrolyte concentration 0.3296045707750669 0.3426053140756823 0.7318954037283221 1.0 1.0 16 Q13423 1 +Decreased muscle mass 0.3326241411715799 0.3402903839211675 0.7336378580508547 1.0 1.0 14 Q9Y487,P04066,O96028 3 +Abnormal rib cage morphology 0.2684811026393577 0.337268703086896 0.7359143502867238 1.0 1.0 72 Q7Z4L5,P02545,P00813,P41227,P15586,Q96HY6,P98172,Q9UHX1,O75844,O96028,P50570,O95831,Q32P28,O75431,P04066,Q03164,Q9H3P2,Q8TAA9,P16435,Q14739,P54802,P16278,O60826 23 +Abnormal vertebral morphology 0.2928337564944703 0.333606872667563 0.7386762314645221 1.0 1.0 101 P00813,Q96HY6,P46100,Q9UHX1,Q10713,Q14108,Q6NUQ1,O96028,O95831,Q32P28,P57740,P04066,P51812,Q9NSE4,Q9H3P2,Q8TAA9,P16435,P54802,P16278,O60826,P61978,P10619,P48735,P04062 24 +Secondary microcephaly 0.2679956518240211 0.331712117669853 0.7401066497171005 1.0 1.0 72 Q5KU26,P55795,Q15043,Q9Y487,O14936,P50897,Q13813,Q96CU9,O15121,Q9UHX1 10 +Reduced visual acuity 0.3045517583034012 0.3311368775530718 0.7405410972064297 1.0 1.0 116 Q15043,P00846,P41227,O96000,P21912,P46100,Q10713,Q9UHX1,P07602,Q9H061,O00459,P50897,Q96CU9,P68371,Q9H6K4,P36404,O43676,P53701,Q969G3,P16278,P06865,O43505,O43681 23 +Abnormally folded helix 0.3274455640692807 0.3305383620880793 0.7409932111488069 1.0 1.0 16 P21964 1 +Bilateral tonic clonic seizure 0.2740075352128227 0.3301822696212055 0.7412622430889213 1.0 1.0 79 P07602,P03915,Q92796,Q13510,P00846,P51812,Q01105,Q00577,P00403,P27544,P04062 11 +Arteriovenous malformation 0.4655791190864543 0.3299252988742587 0.7414564070860459 1.0 1.0 4 Q9BXW9,Q9NVI1,P08236 3 +Atrial arrhythmia 0.3895589042267127 0.3293342302412549 0.7419030738778774 1.0 1.0 7 P02545 1 +Abnormal pulmonary thoracic imaging finding 0.3197902901931083 0.3284958773107105 0.742536760936966 1.0 1.0 19 P21964 1 +Aplasia hypoplasia of the earlobes 0.3555001421191756 0.3277410850465218 0.7431074361944638 1.0 1.0 11 P21964 1 +Supernumerary nipple 0.3663570719975691 0.327389709081962 0.7433731489535895 1.0 1.0 10 P61978,Q7LGA3 2 +Abnormality of ocular smooth pursuit 0.313160899951509 0.3269713816675536 0.7436895306865376 1.0 1.0 21 O14773,P41440 2 +Decreased absent ankle reflexes 0.3473995565878958 0.3258692707284054 0.7445232661340664 1.0 1.0 12 P07196 1 +Opisthotonus 0.3049055081262915 0.3226675992059591 0.7469469927518106 1.0 1.0 23 P07602,Q99720,P35637 3 +Abnormality of the adrenal glands 0.2859888157528031 0.3200663323175294 0.7489180471406369 1.0 1.0 56 P40855,Q969G3,P33991,P02545,O75381,P56589,O75844,P21912,Q9NSE4,Q13423,Q9H4A3,P48735,P16435 13 +Abnormal conus terminalis morphology 0.4048186093873584 0.3174001913671452 0.7509399620253978 1.0 1.0 6 Q9H3P2 1 +Clonus 0.3048397911027704 0.3166982291929978 0.7514725925837902 1.0 1.0 31 P07602,P35637,O75027,Q9BQT8,Q99720 5 +Abnormality of the 1st metacarpal 0.3801332742329755 0.3154114622618376 0.7524492650476611 1.0 1.0 8 O60885,Q15233,Q9UQE7 3 +Abnormality of the lymphatic system 0.3217860769714891 0.3154001976739967 0.7524578167657958 1.0 1.0 141 P14174,P02545,P21964,O14936,P00813,Q96HY6,P46100,O15460,P07602,P33991,Q14108,Q13510,Q6NUQ1,Q16625,Q15392,P28070,P35670,P54802,P16278,P10253,Q01844,O15118,P10619,P48735,P04062 25 +Dystrophic fingernails 0.3526071643446251 0.3141393687816356 0.7534151898988888 1.0 1.0 11 O75844,P02545 2 +Progressive visual field defects 0.6155852624714658 0.3133036718275251 0.7540499607550015 1.0 1.0 2 P35222 1 +Thick nasal alae 0.3437591142628901 0.308154792308298 0.7579645501479826 1.0 1.0 12 P51812 1 +Retinal dystrophy 0.2915201690008955 0.3061474137635294 0.7594924089195974 1.0 1.0 52 P40855,P53701,Q13868,O75381,P03915,Q6P4Q7,Q15067,P36404,P00846,P56589,O43505,Q8NAT1,Q9NQT5 13 +Mild hearing impairment 0.3432762849332206 0.3058241197843674 0.7597385628466957 1.0 1.0 12 P51812 1 +Abnormal lymphocyte morphology 0.3040198290735862 0.3048671718512883 0.7604673193158082 1.0 1.0 37 P00813,P16278,P33991 3 +Ventricular tachycardia 0.3259060427194999 0.3046635496520555 0.7606224137207296 1.0 1.0 14 P23786,O43772 2 +Abnormality of corneal size 0.3038921023501013 0.3032306989525112 0.7617140552992074 1.0 1.0 36 Q96EK5,O43505,P36404,P41227,Q9Y5P6,Q8NAT1,Q9H3P2,Q9NWM8,P07437 9 +Epiphyseal stippling 0.3422003530093546 0.3006466093078995 0.7636839856684587 1.0 1.0 12 P40855,O75381,P56589 3 +Abnormal size of the clitoris 0.3216704699400156 0.2987734637328591 0.7651128995105259 1.0 1.0 16 P53701,O75381,P40855,P56589 4 +Reduced forced expiratory volume in one second 0.6097163351809527 0.2984942371755719 0.7653259738340688 1.0 1.0 2 Q96J02 1 +Sleep wake cycle disturbance 0.4548123980423983 0.2978689065268012 0.7658032202990372 1.0 1.0 4 Q9UBM7,Q8N3U4,Q9Y4R8 3 +Dysgammaglobulinemia 0.6090642321486733 0.2968722588126085 0.7665640361454134 1.0 1.0 2 P98170 1 +Abnormality of thyroid physiology 0.2649258086370287 0.2968499037976019 0.7665811039868897 1.0 1.0 72 P61978,P21964,P00813,Q13423,P00403 5 +Dysphagia 0.3089520350714302 0.2946757476456449 0.7682415915238883 1.0 1.0 126 Q9NR77,O43819,P04062,P20700,P00846,P21912,P15586,Q96CV9,Q8NFF5,Q8IZA0,Q9UHX1,P07602,P67870,P35637,Q14108,P43243,P17480,P09471,Q15067,Q13510,Q9UBB4,O75874,O75569,Q92734,P06753,P29372,Q01105,Q8N183,Q03164,Q15233,P35670,Q14739,O15344,P03915,O75306,Q12959,O15118,Q9UEY8,P48735,Q99720 40 +High anterior hairline 0.3222911485032366 0.29302890645837 0.7695000568332477 1.0 1.0 15 O15344,Q9H3P2,P98172,Q7LGA3,O96028 5 +Osteolytic defects of the distal phalanges of the hand 0.4530387979286704 0.2927192667924921 0.7697367418660306 1.0 1.0 4 O75844,P02545 2 +Cutaneous syndactyly 0.3743874550800348 0.2922081874786824 0.7701274519894297 1.0 1.0 8 O60716,Q9Y619,P51608,P21281,P98175,Q9Y2U8,P27635 7 +Posterior pharyngeal cleft 0.4523285297194418 0.2906676555024032 0.7713055111695319 1.0 1.0 4 O15344 1 +Motor polyneuropathy 0.3474461113276643 0.2902436400665057 0.7716298524378751 1.0 1.0 11 O43819,P36551,P07196,P50336 4 +Difficulty running 0.323062008361605 0.2898791951179952 0.7719086584760686 1.0 1.0 14 Q8TD16,P06753,P07196,Q9Y5P6,Q9BPX6 5 +Delayed ability to stand 0.5915402395467636 0.289815852408615 0.7719571196368777 1.0 1.0 3 P10253 1 +Accessory spleen 0.3967562623318625 0.2888127015509759 0.7727247116941329 1.0 1.0 6 Q15904 1 +Hyperostosis 0.3214647687575257 0.2886645119192763 0.7728381224690721 1.0 1.0 15 Q15043,P51812 2 +Abnormality of toe 0.3310570371080333 0.2874041175707256 0.7738029087723537 1.0 1.0 158 Q9NR77,Q7Z4L5,P04062,Q9UGU0,P02545,P21964,O14936,P39210,Q96A33,P00813,P41227,O43924,P98172,Q08J23,Q7LGA3,Q10713,Q9UHX1,Q96BR5,Q92796,P09471,Q13510,O75844,O96028,O75431,P51812,Q9H4A3,Q03164,Q9H3P2,Q15233,P37268,Q969G3,O60826,P61978,P07196,P23786,Q8WVM7,Q99720 37 +Fasting hyperinsulinemia 0.4511471141295085 0.2872687129567374 0.7739065769268545 1.0 1.0 4 P02545 1 +Leiomyosarcoma 0.3960169768201108 0.2862359115420815 0.7746974404150155 1.0 1.0 6 P04637,P63167,P35222,P25054,O60566 5 +Delayed epiphyseal ossification 0.5894230396381777 0.284735768034729 0.7758465854912875 1.0 1.0 3 Q96HY6 1 +Curly hair 0.3461608973547211 0.284369257983834 0.7761274154959992 1.0 1.0 11 Q14004,P55795 2 +Colorectal polyposis 0.3952388542388586 0.2835320377903662 0.7767690262039169 1.0 1.0 6 P21912 1 +Developmental regression 0.3078914666288099 0.2828492260561427 0.77729241748865 1.0 1.0 126 Q15043,O14936,P00846,P21912,P07602,P40855,O75381,Q15067,Q13510,Q8NI60,O95831,P55795,O75503,Q13813,P56589,O14773,P16278,Q96F07,P03915,Q9H9P8,O43681 21 +Oligodontia 0.3659086756001302 0.2827204468142558 0.7773911411502339 1.0 1.0 9 P51812 1 +Abnormal peristalsis 0.3771842953802825 0.2814862821683849 0.7783374481636618 1.0 1.0 7 Q9NSE4 1 +Weakness of facial musculature 0.2735800369796509 0.2812391308744299 0.7785269932339063 1.0 1.0 60 P50570,P40855,Q969G3,Q15043,O75381,Q92796,P07196,Q13510,P56589,P51812,Q9BQT8,P16219,Q9UHX1 13 +Telangiectasia of the skin 0.3153979673069298 0.2752876209770704 0.783095274228732 1.0 1.0 17 Q8IZA0,P06280,P02545,P46100 4 +Abnormal number of incisors 0.3922556154418937 0.2732452651736932 0.7846646868030922 1.0 1.0 6 Q12959 1 +Delayed ability to walk 0.265516803899668 0.2727821890156953 0.7850206516282277 1.0 1.0 63 Q9UGU0,P20700,Q99720,P35637,P61978,O14936,Q01105,P49366,P21912,Q96N66,Q03252,Q14004,Q3ZCQ8,P48449,Q15233 15 +Abnormality of the posterior pituitary 0.3746864779012273 0.2721012350178547 0.7855441799550071 1.0 1.0 7 Q9UHX1 1 +Gastroparesis 0.3742876931472713 0.2706117416151929 0.7866896641825716 1.0 1.0 7 P61978 1 +X linked dominant inheritance 0.2926868511467895 0.2697179400805384 0.7873772577025717 1.0 1.0 24 P51812,P53701,P46100 3 +Exercise induced myalgia 0.3532271792077496 0.2696451600521212 0.7874332540330025 1.0 1.0 10 P50570,Q13586,P23786,P02545 4 +Joint hypermobility 0.2796257025891545 0.2687644943729276 0.7881109176827437 1.0 1.0 92 P35670,P02545,Q9Y487,P21964,Q01105,P51812,Q03164,Q7LGA3,Q03252,Q14004,Q08J23,Q9NWM8,Q9UHX1 13 +Nasolacrimal duct obstruction 0.4441399198939758 0.2674630502460718 0.7891126597975935 1.0 1.0 4 Q13428 1 +Typical absence seizure 0.3184508611885039 0.2663069316598243 0.7900028351100907 1.0 1.0 14 Q13510,Q01105 2 +Gonosomal inheritance 0.2594575307664103 0.265443984925433 0.7906674559460729 1.0 1.0 69 P78318,O14936,P41227,P98175,P46100,P98172,Q15904,Q92796,O95831,P55795,O75027,P38159,P51812,Q15233,P53701,O60826,O15344,P06280,P50402 19 +Acquired abnormal hair pattern 0.3727173738082776 0.2647704770676524 0.7911862813254782 1.0 1.0 7 P02545 1 +Neoplasm of the breast 0.2938324716587809 0.2639339146074219 0.7918308418741393 1.0 1.0 26 P48735,P78549,P02545,P46100 4 +Tremor 0.3340162282612849 0.2614410144143754 0.7937524315951354 1.0 1.0 166 Q9NR77,P04062,Q15043,O14936,P00846,P21912,O43924,P32929,Q9BPX6,P07602,P35637,Q14108,Q13510,Q8NI60,O95831,P41440,O75503,O75027,Q9H6K4,O14773,Q15233,P35670,Q96F07,P03915,P07196,Q5JRX3,P61457,Q6DKK2,Q99720,O43681 30 +Hyperkalemia 0.4032892846844069 0.2605655035132789 0.7944275950857935 1.0 1.0 5 Q13423 1 +Renal tubular dysfunction 0.2975611871501074 0.259360769179773 0.7953568959331045 1.0 1.0 39 P35670,O43676,Q96CU9,O96000,P00403 5 +Stage 5 chronic kidney disease 0.2910553582753678 0.2591345516649571 0.7955314266862659 1.0 1.0 24 Q8N1F7,Q7Z4L5,Q14C86,P23786,Q8NFH4 5 +Abnormal circulating follicle stimulating hormone concentration 0.3710606953397294 0.2586498816423919 0.7959053924834452 1.0 1.0 7 Q969G3 1 +Abnormal bleeding 0.2893573941160942 0.258518682073469 0.7960066326238098 1.0 1.0 105 P35670,P50570,Q969G3,Q13126,P04062,P02545,Q14108,Q9Y487,P21964,P23786,O75844,P46100,Q16625,O15460,Q9NWM8,Q9UHX1,P11117 17 +Hyperextensible skin 0.3154275681923152 0.2572799340972937 0.7969626814766033 1.0 1.0 15 Q9NWM8,Q9UHX1 2 +Cerebral visual impairment 0.2664568517537917 0.2565841880825781 0.797499782530366 1.0 1.0 62 P37268,P03915,Q01105,Q96CU9,P00403,Q08J23 6 +Polycystic kidney dysplasia 0.3163599418555022 0.2557864162238222 0.7981157633544711 1.0 1.0 14 P21964 1 +Abnormality of exocrine pancreas physiology 0.3116626856939402 0.2551106986271735 0.7986376011897061 1.0 1.0 17 P14174,P09601 2 +Progressive microcephaly 0.2969845387178784 0.2550528307237114 0.7986822951412573 1.0 1.0 39 Q5KU26,Q15043,Q9Y487,O14936,P50897,Q13813 6 +Abnormality of globe size 0.2750747719261121 0.2533943640666319 0.7999634824031281 1.0 1.0 58 P53701,O75569,Q9BUK6,P21964,O14936,O00459,O75431,O43505,P41227,Q8NAT1,O43924,Q9UHX1,P07437 13 +Aplasia hypoplasia of the nipples 0.3131189489366413 0.253206754117773 0.8001084475180642 1.0 1.0 16 O60885,O60826,P07437,Q96A33,Q9H3P2,P98172,O96028 7 +Ectopic anus 0.3241979974104926 0.2526490755764543 0.8005394031211523 1.0 1.0 13 P53701,P16435,O60826 3 +Akinesia 0.3487782603185893 0.2507647471267129 0.801995998560123 1.0 1.0 10 P51114,Q99567,P04062 3 +Easy fatigability 0.3004836920814829 0.2499495349675702 0.8026263753184288 1.0 1.0 21 P50570,P06753,P61978,P21912,Q9Y5P6,Q9NWM8 6 +Abnormal thalamic mri signal intensity 0.3852453616582301 0.2495823817153242 0.8029103248359233 1.0 1.0 6 Q96EY7,Q969G3 2 +Abnormal cranial nerve morphology 0.2580532336500992 0.249121224561631 0.8032670120905832 1.0 1.0 65 P50570,P40855,Q969G3,Q15043,O75381,Q92796,P07196,Q13510,P56589,P51812,P21912,P16219,P22626,Q9UHX1 14 +Abnormality of fontanelles 0.2921523310196489 0.2487400092670222 0.8035618983465225 1.0 1.0 46 Q32P28,P02545,Q9Y487,O75381,O75844,P51812,P98175,P46100,Q08J23 9 +Hypoplastic toenails 0.2969089728691636 0.248364751632134 0.8038522034106617 1.0 1.0 22 Q08J23,P23786 2 +Weak cry 0.3848197974931686 0.2481694892228755 0.8040032721116477 1.0 1.0 6 Q13510 1 +Impaired visuospatial constructive cognition 0.3573849096681725 0.2479843372860658 0.8041465254037194 1.0 1.0 9 P00403 1 +Hypoplasia of the uterus 0.3479945619235799 0.2474769784902069 0.8045391059914868 1.0 1.0 10 P53701 1 +Large beaked nose 0.3836108390466896 0.2441707063440158 0.8070986134821818 1.0 1.0 6 Q9Y3Z3,O14802,P18074,P55265,Q12797 5 +Lower limb hypertonia 0.3371219928044686 0.2439595998125152 0.8072621093375894 1.0 1.0 11 P21912,P46100 2 +Emg myopathic abnormalities 0.2924227557747735 0.2433920755229603 0.8077016820852951 1.0 1.0 28 P50570,P51114,P02545,P06753,P07196,P50402,P22626 7 +Distal sensory impairment of all modalities 0.3975195822454411 0.2430389446382229 0.8079752282819617 1.0 1.0 5 O95140,O15269,O15270,P48643 4 +Lumbar hyperlordosis 0.3091824037406182 0.2419189056933432 0.8088430005528258 1.0 1.0 17 P06753,P04066,P41227,Q9Y5P6,Q96HY6 5 +Hoarse voice 0.2891806789435209 0.2401057018384921 0.8102483140662449 1.0 1.0 25 P06753,P43243,Q13510,Q96HY6,Q01082 5 +Delayed eruption of permanent teeth 0.4336052202283837 0.2388632455975342 0.8112116264246825 1.0 1.0 4 Q9UJX6,Q12824,Q5JRA6 3 +Iris coloboma 0.294471707790695 0.2386340656033853 0.8113893475980678 1.0 1.0 33 P78318,Q96EK5,P53701,Q10713,O60826,O43505,P41227,Q8NAT1,Q9H3P2,Q01082,Q9UHX1,O96028 12 +Abnormal cellular phenotype 0.3441010863675935 0.2344669179264761 0.8146225130976683 1.0 1.0 186 P14174,O43772,P21964,P00846,P00813,O96000,Q9Y584,P07602,P33991,P35637,Q14108,P09601,Q13510,Q96CU9,Q70HW3,Q9Y2R0,P28070,O75503,O43676,P00403,O14773,P03915,P23786,Q9UBX3 24 +Insulin resistance 0.3090653129550822 0.2322659151613832 0.8163314843337512 1.0 1.0 16 O75844,O75431,P02545,Q03252 4 +Thin skin 0.2867322686408718 0.231531529635353 0.8169018936763035 1.0 1.0 24 O75844,Q13126,P02545 3 +Sparse eyebrow 0.2933495844745496 0.2309025361229228 0.8173905204314662 1.0 1.0 33 Q96EK5,P02545,P61978,Q07954,O75431,O75844,Q00577,Q08J23 8 +Erythrocyte inclusion bodies 0.3932886490693866 0.2304936255937454 0.8177082161979108 1.0 1.0 5 O14936 1 +Astrocytoma 0.3583123413715529 0.2300604908583602 0.8180447651877558 1.0 1.0 8 P48735,P20585 2 +Limited elbow extension 0.3581689661160638 0.2295257119549663 0.8184603387310492 1.0 1.0 8 Q9H6K4,P16435 2 +Short clavicles 0.3519730913793092 0.226586304761751 0.8207454425553822 1.0 1.0 9 O75844,O75431,P02545 3 +Aplasia hypoplasia of the skin 0.2838457899115064 0.2260300334456418 0.8211780614092552 1.0 1.0 51 P53701,Q13126,P02545,Q07954,O75844,Q15392,Q9NWM8 7 +Decreased circulating acth level 0.3773171733672711 0.2237185523983756 0.8229763090850302 1.0 1.0 6 Q969G3 1 +Episodic ataxia 0.3909151586712095 0.2235721470721788 0.8230902384906087 1.0 1.0 5 O14936 1 +Abnormal lower limb bone morphology 0.3238624676263297 0.2227067719348174 0.8237637304830041 1.0 1.0 156 Q9UGU0,Q7Z4L5,P02545,P21964,O14936,Q99567,Q96A33,P00813,P98175,O43924,Q96HY6,P46100,Q08J23,Q7LGA3,Q9UHX1,P07602,Q9Y487,Q13510,O75844,Q6NUQ1,Q03252,Q15392,O95831,Q32P28,O75431,Q9UPT5,P51812,Q8NAT1,Q9H4A3,Q03164,Q9H3P2,P16435,P16278,P06280,P04062 35 +Abnormal levels of alpha fetoprotein 0.4270799347471374 0.2218832705565367 0.8244047541034187 1.0 1.0 4 P35222,Q15149,Q9UJS0 3 +Protein losing enteropathy 0.5607969785933484 0.2204821726495217 0.8254956549503403 1.0 1.0 3 P34949 1 +Buphthalmos 0.5751548744701583 0.2192790981906636 0.8264326429279394 1.0 1.0 2 Q14118 1 +Abnormality of female external genitalia 0.2915791079343392 0.2188011336275224 0.8268049637643966 1.0 1.0 33 P40855,P53701,P02545,O75381,P56589,Q15392,Q08J23 7 +Sudden loss of visual acuity 0.5748288229540186 0.218599183634213 0.8269622887872892 1.0 1.0 2 P35222 1 +Atrophy degeneration affecting the brainstem 0.3308724292385003 0.2169978189243866 0.8282100446916127 1.0 1.0 11 Q13813,Q13217,O15121 3 +Neuroendocrine neoplasm 0.3236187341311541 0.215007316260011 0.8297616144058968 1.0 1.0 12 P02545,P46100 2 +Abnormality of hair texture 0.2811282799908329 0.2144908701781042 0.8301642858450957 1.0 1.0 52 P55795,P54802,Q9Y487,P51812,O75844,Q08J23 6 +Vertebral fusion 0.3482867675491389 0.212317515292118 0.8318593316921135 1.0 1.0 9 Q8TAA9,Q9UHX1,O96028 3 +Simple ear 0.373382192815739 0.2112498101891178 0.832692344737431 1.0 1.0 6 P16435 1 +Muscular dystrophy 0.2874799967573478 0.2111807422603495 0.83274623733844 1.0 1.0 28 Q9BTV4,P02545,Q15149,P09651,O43505,O14979,P50402,Q9Y5P6,Q8NAT1,P22626,Q9H173 11 +Protrusio acetabuli 0.5561579723739589 0.2108741918984767 0.832985443170275 1.0 1.0 3 O75718 1 +Lung adenocarcinoma 0.5560991519895466 0.210753848822524 0.8330793529002236 1.0 1.0 3 P30154,Q99496 2 +Adult onset 0.2618272412679499 0.2094267392255996 0.8341151206648854 1.0 1.0 62 P07602,Q969G3,P20700,P04062,P41440,P02545,Q8IV08,Q9Y6M1,P43243,Q16637,Q13586,Q14566,O14979,P21912,P36551,O15118,Q07021 17 +Extramedullary hematopoiesis 0.4216088698465347 0.2080934754504175 0.8351559814905674 1.0 1.0 4 P98175 1 +Purpura 0.2931962597934143 0.2078629165172901 0.8353360050422773 1.0 1.0 21 P21964 1 +Broad finger 0.2888457723126794 0.2066127116848959 0.8363123319844146 1.0 1.0 31 Q9UGU0,O14936,P51812,Q08J23,Q7LGA3,Q9UHX1 6 +Aplasia hypoplasia of the eyebrow 0.2888714642444421 0.2061839269249199 0.8366472425657938 1.0 1.0 43 Q96EK5,P02545,P61978,Q07954,O75431,P00813,O75844,Q00577,Q8WVM7,P48449,Q08J23 11 +Abnormality of the metacarpal bones 0.2904190358014413 0.2061175262705171 0.836699108722871 1.0 1.0 36 P51812,O43924 2 +Epileptic spasm 0.2637331960520455 0.2055483106855936 0.8371437573131804 1.0 1.0 61 P03915,Q13813,Q13510,Q01105,P00846,Q96N66,Q00577,Q08J23,Q9UBX3 9 +Abnormal urine ph 0.2887526883303766 0.2052874217023459 0.8373475708131903 1.0 1.0 43 O43772,P03915,P23786,P00846,O96000,Q9H9P8,Q9BQT8,P48735 8 +Hyperactive patellar reflex 0.3515321536949259 0.2051719105188318 0.8374378147480455 1.0 1.0 8 Q15233,P21912,O95394 3 +Ileus 0.5530391456369506 0.204544699071601 0.8379278654647975 1.0 1.0 3 Q01844 1 +Abnormal head movements 0.3278414849829767 0.2042261824277703 0.8381767518902383 1.0 1.0 11 P41227,Q99720,P20700,P35637 4 +Patellar aplasia 0.5527886511079427 0.2040408932893166 0.8383215428305246 1.0 1.0 3 Q9Y5S9 1 +Bowing of the arm 0.4198097215373838 0.2036493336896963 0.8386275381983321 1.0 1.0 4 Q32P28 1 +Decreased corneal reflex 0.419712292974334 0.2034099628279433 0.8388146133764856 1.0 1.0 4 Q9H4A3 1 +Abnormality of the incisor 0.2853644660815452 0.2032619980360331 0.8389302566516681 1.0 1.0 27 Q9UGU0,Q12959,Q00577,Q8WVM7,P46100,Q7LGA3 6 +Ureteropelvic junction obstruction 0.5670035865666692 0.2026696657842991 0.8393932343024002 1.0 1.0 2 Q9UBM7 1 +Leukoencephalopathy 0.2743907225675819 0.2025724997449562 0.8394691863551502 1.0 1.0 93 P07602,O95831,O00584,O75503,P07942,Q01105,O43676,Q96CU9,O96000,Q9H9P8,O15121,Q9UHX1,O43681 13 +Exostoses 0.4192070327612205 0.2021707293999058 0.8397832551802542 1.0 1.0 4 P48735 1 +Delayed eruption of teeth 0.2862977943101269 0.2021666173282405 0.8397864697692741 1.0 1.0 46 P02545,Q9Y487,Q92796,O75844,P51812,Q08J23 6 +Limited hip movement 0.3052850354412174 0.2019294475225093 0.8399718804583995 1.0 1.0 14 O75844,Q8TD16,Q7LGA3,P02545 4 +Joint hyperflexibility 0.2895629992092396 0.1999226304511355 0.8415410911835353 1.0 1.0 38 P51812,P21964,Q08J23 3 +X linked recessive inheritance 0.2779821884163463 0.1998175611979713 0.8416232664453824 1.0 1.0 53 P78318,O95831,O60826,Q15904,O75027,Q92796,O14936,O15344,P06280,P41227,P38159,P98175,P50402,P46100,Q15233 15 +3 methylglutaconic aciduria 0.3267019982190645 0.1994776738466383 0.8418891060934635 1.0 1.0 11 Q3ZCQ8,Q9H6K4 2 +Impaired smooth pursuit 0.303590546272251 0.1984825093974913 0.8426675680078755 1.0 1.0 15 P41440 1 +Progressive muscle weakness 0.3111253488683211 0.1922168486168225 0.8475723486955542 1.0 1.0 13 P40855,P06753,O75381,P56589,Q15149 5 +Macular thickening 0.3503466944231787 0.1859811909410466 0.8524595114454656 1.0 1.0 7 P50213,Q8WWY3,P04439 3 +Abnormality of the antihelix 0.3325932505843949 0.1853274093892698 0.8529722408079974 1.0 1.0 10 P98175,Q08J23 2 +Abnormal thalamic size 0.5422515876940728 0.1834675362127017 0.8544311887596217 1.0 1.0 3 Q9UPT5 1 +Moderate global developmental delay 0.3320025528250634 0.1830414571202562 0.8547654900076991 1.0 1.0 10 O95831 1 +Abnormality of limb epiphysis morphology 0.28295789470671 0.1825265686359773 0.8551695058055677 1.0 1.0 28 P51812,O95831,Q7LGA3 3 +Aplasia hypoplasia of the 5th finger 0.3010931936276347 0.1824129035724986 0.8552587001049043 1.0 1.0 14 Q969G3,O14497,Q12824,Q92785,Q9UHX1 5 +Osteomyelitis 0.2989273861057643 0.181909493935089 0.855653753729096 1.0 1.0 16 Q13126 1 +Abnormality of the septum pellucidum 0.2868374621556457 0.1814202381373589 0.8560377347138075 1.0 1.0 39 P53701,Q9BVA1,O43505,Q96N66,Q8NAT1,Q15392,Q08J23 7 +Adrenocorticotropic hormone deficiency 0.5559178350179237 0.1813893239006246 0.8560619981762003 1.0 1.0 2 O00170 1 +Lambdoidal craniosynostosis 0.5410573792154858 0.1812126903424961 0.8562006340540222 1.0 1.0 3 P61978 1 +Lactose intolerance 0.5410239307471804 0.181149761033265 0.856250026986644 1.0 1.0 3 Q14566 1 +Abnormal conjunctiva morphology 0.2825911126259383 0.1802381342087751 0.8569656218583384 1.0 1.0 28 P28070,P06280,P04066,Q13510,P21912,P02786,Q9NSE4,P10619 8 +Abnormal epidermal morphology 0.2970292705880292 0.1798250584526908 0.8572899104899545 1.0 1.0 17 Q07954,O75844,P02545,Q06136 4 +Abnormality of cranial sutures 0.2644815783109659 0.1778655255253779 0.8588285857349638 1.0 1.0 84 P40855,O95831,Q32P28,P02545,P61978,Q9Y487,P21964,O75381,O75431,P51812,P41227,P98175,O75844,Q00577,Q9H4A3,Q08J23,P16435 17 +Agammaglobulinemia 0.5391389432485146 0.1776233501921059 0.8590187853419646 1.0 1.0 3 Q8IWT6,O60220 2 +Aplasia hypoplasia affecting the fundus 0.2798092201572051 0.1749780091172138 0.8610969131743742 1.0 1.0 26 P61978,P37268,P07196,Q9UHX1 4 +Abnormal eating behavior 0.2920489687298434 0.1738783793021028 0.8619610446010704 1.0 1.0 19 Q969G3,O14497,P35610,P49366,Q92785,Q4J6C6 6 +Abnormal blood sodium concentration 0.3294690368313875 0.1733228331818859 0.8623976770136454 1.0 1.0 10 P36551,Q13423 2 +Lipodystrophy 0.2840873411439123 0.1720794451708594 0.8633750720855939 1.0 1.0 32 P28070,P02545,Q9Y487,O75431,O75844,Q03252 6 +Tonic seizure 0.278169272861957 0.1717459157036845 0.8636372865870914 1.0 1.0 25 P07602,Q00577,Q01105 3 +Rod cone dystrophy 0.2853980901291368 0.1708394680943094 0.8643499941991892 1.0 1.0 38 P40855,Q13868,O75381,P03915,Q15067,P00846,P56589 7 +Medial flaring of the eyebrow 0.549070753178994 0.1690043694439402 0.8657932045210011 1.0 1.0 2 Q96ST3 1 +Milia 0.5340765139170205 0.1683473633129865 0.866310014988191 1.0 1.0 3 P50336 1 +Poor speech 0.264377209377801 0.1677680228514323 0.8667657799586235 1.0 1.0 85 O00584,P61978,Q15043,Q9Y487,Q92796,Q01105,P51812,Q96CU9,Q96N66,P55263,Q08J23 11 +Skeletal muscle atrophy 0.3226587589292066 0.1663033138686478 0.8679182582728004 1.0 1.0 162 Q9NR77,Q8TD16,P02545,P39210,Q99567,P21912,P55263,Q96CV9,Q9NQT5,Q96BR5,P35637,Q9BVA1,O00459,Q13510,O14979,Q15165,Q03252,P50995,P50570,O95831,Q13126,P06753,P51812,Q8NAT1,Q9NWM8,P22626,Q92804,P16278,P07196,P50402,Q9BQT8,Q6DKK2,Q99720 33 +Abnormality of the intrahepatic bile duct 0.5328825442146916 0.166201110378595 0.8679986856454711 1.0 1.0 3 P02545 1 +Neoplasm of the parathyroid gland 0.3699351389530544 0.1661891146642021 0.8680081255672285 1.0 1.0 5 P48735 1 +Parathyroid adenoma 0.3699351389530544 0.1661891146642021 0.8680081255672285 1.0 1.0 5 P48735 1 +Abnormal corneal epithelium morphology 0.2905416223539298 0.166153324139479 0.8680362907171713 1.0 1.0 19 Q96EK5,O75844,P39210,P02545 4 +Adenomatous colonic polyposis 0.368954015544674 0.163678494151521 0.8699842483822515 1.0 1.0 5 P78549 1 +Bulbous nose 0.28368838504579 0.1621371456153865 0.8711978552137625 1.0 1.0 41 Q9UGU0,Q96EK5,P21964,P23786,O75431,P38159,P42892 7 +Abnormal size of pituitary gland 0.3680108490363192 0.1612799863643552 0.8718728854690798 1.0 1.0 5 Q969G3 1 +Breast carcinoma 0.2893770684450853 0.1602381446080603 0.8726934825396597 1.0 1.0 19 P48735,P78549,P46100 3 +Broad clavicles 0.5438539289207597 0.1599581985628443 0.8729140028543692 1.0 1.0 2 A1X283 1 +Vocal cord paresis 0.4008224731597943 0.1595596127767874 0.8732279956162823 1.0 1.0 4 P43243 1 +Syndactyly 0.2583956452766329 0.1590499573337099 0.8736295144839081 1.0 1.0 79 P37268,Q7Z4L5,P02545,Q92796,P51812,P98175,O43924,Q08J23,Q9UHX1 9 +Pace of progression 0.3171580105402865 0.1579152331217976 0.8745235943830736 1.0 1.0 155 Q9NR77,P04062,P02545,Q15043,Q9NR28,P39210,O43707,P55263,P27544,O00584,Q8IV08,Q14108,Q13510,O14979,Q03252,P50570,O95831,Q13126,P41440,O15121,O14773,Q8N1F7,P54802,P07942,P07196,P50402,Q99720 27 +Cardiac arrest 0.2805733558895622 0.157753319977823 0.8746511832171715 1.0 1.0 30 P02545,O43772,P50402,O15460,Q14BN4 5 +Limb fasciculations 0.3997934381507936 0.1573197671503989 0.8749928423012798 1.0 1.0 4 Q92734,Q16637 2 +Osteomalacia 0.3991093596430143 0.155839420931236 0.8761595968050448 1.0 1.0 4 P35670,P53680 2 +Abnormality of epiphysis morphology 0.2727902281586224 0.155768363706604 0.8762156082897576 1.0 1.0 53 Q7Z4L5,P40855,O95831,P16278,O75381,P56589,P51812,Q6NUQ1,Q96HY6,Q9H4A3,Q7LGA3 11 +Oral pharyngeal dysphagia 0.3024512476132063 0.1545617815740272 0.8771668017271828 1.0 1.0 13 Q13510,Q12959,Q01105 3 +Joint stiffness 0.2711600711648954 0.1541815489496968 0.8774665900307139 1.0 1.0 54 P16435,O60885,P54802,P16278,P02545,Q8NBU5,P51648,O75431,P48735,O75844,P50402,P15586,P46100,Q8TAA9,O15460,O75874 16 +Relative macrocephaly 0.2815548797998885 0.1526731116149044 0.878656065965624 1.0 1.0 33 P02545,O75844,Q15392,Q7LGA3,Q15233 5 +Distal sensory loss of all modalities 0.3973898858075015 0.1521490542304271 0.8790693748666509 1.0 1.0 4 O15269,O15270,P48643 3 +Microcornea 0.2746349595841242 0.1508200544637083 0.8801176660505596 1.0 1.0 25 O43505,P36404,Q8NAT1,Q9NWM8,P07437 5 +Abnormal systemic arterial morphology 0.2986529895819765 0.1507314012808041 0.8801876015879273 1.0 1.0 130 Q9UGU0,P02545,P21964,P00846,P21912,P55263,O15460,Q7LGA3,Q9UHX1,P07602,O00459,Q13510,O75844,P46783,P06753,Q9NWM8,P53701,P16278,P61978,P06865,P03915,P10253,O15118,P10619,P04062 25 +Abnormal form of the vertebral bodies 0.2591105510032993 0.1485051061346111 0.8819441565255446 1.0 1.0 81 O95831,P54802,P16278,P00813,P51812,Q6NUQ1,Q96HY6,P46100,P48735,Q9UHX1 10 +Oligohydramnios 0.2782638025307456 0.148359147094858 0.8820593391181619 1.0 1.0 29 P51114,P23786,P49366,Q7LGA3,P16435,Q9UHX1 6 +Ankyloblepharon 0.3628188184457455 0.1483414568640685 0.8820732994140943 1.0 1.0 5 O75569 1 +Chronic constipation 0.2739810252572995 0.1470056689075085 0.8831275457956673 1.0 1.0 25 P78318,P55795,Q03252,Q7LGA3,P04062 5 +Long penis 0.5357026410172726 0.146498207164462 0.883528105125968 1.0 1.0 2 O00170 1 +Increased circulating androgen concentration 0.5357026410172719 0.1464982071644608 0.8835281051259689 1.0 1.0 2 P04637 1 +Papilloma 0.3221593084165658 0.1460828542153056 0.8838559815624314 1.0 1.0 10 P21912,P20585 2 +Neoplasm of the respiratory system 0.3071010602166465 0.1456185595359136 0.884222515772563 1.0 1.0 12 P02545 1 +Abnormal urinary color 0.3607850755745438 0.1433966377225532 0.8859769382428597 1.0 1.0 5 P23786 1 +Abnormality of facial soft tissue 0.2841502539197428 0.1432164499726324 0.8861192385446188 1.0 1.0 112 Q14C86,P02545,Q9BUK6,Q15043,P21912,O43707,P16219,Q9UHX1,O00592,P40855,O75381,Q92796,Q13510,O75844,Q9Y5P6,Q03252,P28070,P50570,P06753,P57740,Q8NFH4,P56589,P51812,Q01082,P16435,Q8N1F7,Q969G3,O60826,P10253,P07196,Q12769,Q00577,Q9BQT8,P04062 34 +Hypoproteinemia 0.5321160743397352 0.1408357157635796 0.8879997271567768 1.0 1.0 2 Q9UJS0 1 +Persistent head lag 0.3357873358237278 0.1395507137830829 0.8890149841449455 1.0 1.0 7 Q5XKP0,Q15233 2 +Motor seizure 0.2741463223367154 0.1392529586964175 0.8892502611346236 1.0 1.0 100 P07602,P16278,O75503,P03915,O14936,Q9UPT5,P00846,Q13510,Q01105,Q96N66,Q13813,Q00577,Q08J23,Q9UBX3,P04062 15 +Aplasia hypoplasia of the uterus 0.2896446977524908 0.1385287440660858 0.8898225541305138 1.0 1.0 16 P53701 1 +Abnormality of the uterus 0.2751751951810817 0.1367222880439231 0.8912503116564181 1.0 1.0 49 P51812,P21964,P53701 3 +Porokeratosis 0.5153294194389885 0.1364856543421777 0.8914373646015556 1.0 1.0 3 P14324,Q15126 2 +Ankyloglossia 0.3313957742881945 0.1363979683823429 0.8915066796655726 1.0 1.0 8 O75844,P02545 2 +Cerebral hemorrhage 0.3041290374087112 0.133881913471405 0.8934959524756476 1.0 1.0 12 Q969G3,P23786 2 +Pilomatrixoma 0.5133724722765649 0.1333864856814196 0.8938877327661305 1.0 1.0 3 P25054,P35222 2 +Elevated urinary delta aminolevulinic acid 0.5116949578062673 0.1307639819975039 0.8959620164844855 1.0 1.0 3 P36551 1 +Elevated urinary dicarboxylic acid level 0.5116949578062673 0.1307639819975039 0.8959620164844855 1.0 1.0 3 P36551 1 +Respiratory paralysis 0.5116949578062673 0.1307639819975039 0.8959620164844855 1.0 1.0 3 P36551 1 +Porphyrinuria 0.5116949578062673 0.1307639819975039 0.8959620164844855 1.0 1.0 3 P36551 1 +Abnormality of pancreas physiology 0.279112917765112 0.1301912009701204 0.8964151559393503 1.0 1.0 41 P14174,P02545,P03915,P09601,P00403,P53985 6 +Autoimmunity 0.27850490571705 0.1263858851627479 0.8994264745656497 1.0 1.0 36 P00813,P14174,P21964,Q8IZA0 4 +Aplasia hypoplasia of the nasal bone 0.5084801043704961 0.1258261050459612 0.8998695771592669 1.0 1.0 3 Q6NUK1,O14974 2 +Adrenocortical carcinoma 0.5084801043704948 0.1258261050459595 0.8998695771592682 1.0 1.0 3 P25054,P04637 2 +Moyamoya phenomenon 0.3833605220228417 0.1236878368755609 0.9015624424712256 1.0 1.0 4 Q63HN8,Q9Y3Z3,P55265 3 +Chronic leukemia 0.3833605220228415 0.1236878368755604 0.901562442471226 1.0 1.0 4 P11274,Q9Y3Z3,P55265 3 +Abnormal saccadic eye movements 0.269074345968462 0.1189762105982256 0.9052942030832848 1.0 1.0 25 Q8IV08 1 +Nausea and vomiting 0.3034523897999497 0.1171595907129791 0.9067335882654988 1.0 1.0 141 P07602,Q92804,P35637,P61978,P03915,P39210,P00846,O43676,Q96CU9,O96000,Q15165,Q13423,P00403,P42892,Q9Y584,P46100,Q8IZA0,P11117 18 +Facial erythema 0.5151613955004826 0.1161960879856003 0.9074971370882996 1.0 1.0 2 O00170 1 +Spastic paraplegia 0.272491826664851 0.1161929307248363 0.9074996392695964 1.0 1.0 49 O95831,P07942,P56589,P00846,Q96CU9,P46100 6 +Neoplasm of the tracheobronchial system 0.5132050864036487 0.1135765100534658 0.9095735090977302 1.0 1.0 2 P30154 1 +Germinoma 0.513205086403648 0.1135765100534649 0.9095735090977308 1.0 1.0 2 P35222 1 +Central primitive neuroectodermal tumor 0.5132050864036402 0.1135765100534546 0.909573509097739 1.0 1.0 2 P04637 1 +Abnormality of the musculature of the hand 0.2762487759950225 0.1106046604189053 0.9119298516852627 1.0 1.0 37 Q9NR77,P46783,P07196 3 +Alopecia totalis 0.3258063987197578 0.1101332850441654 0.912303671063067 1.0 1.0 7 P02545 1 +Poikilocytosis 0.2910418073526436 0.1082813423815923 0.9137725222113902 1.0 1.0 13 P41440 1 +Abnormality of hair pigmentation 0.2744301124770331 0.1080617782801089 0.9139466870721218 1.0 1.0 21 P37268,Q13126 2 +Hand tremor 0.3029733979750302 0.1076745037947469 0.9142538949298152 1.0 1.0 11 Q92734,P07196,Q16637 3 +Pituitary prolactin cell adenoma 0.5083143136615522 0.1072265706960418 0.9146092365787823 1.0 1.0 2 O00170 1 +Elevated circulating growth hormone concentration 0.5083143136615522 0.1072265706960418 0.9146092365787823 1.0 1.0 2 O00170 1 +Congenital craniofacial dysostosis 0.5083143136615482 0.1072265706960368 0.9146092365787865 1.0 1.0 2 Q6NUK1 1 +Mild postnatal growth retardation 0.5083143136615482 0.1072265706960368 0.9146092365787865 1.0 1.0 2 Q9Y3E5 1 +Abnormal thyroid stimulating hormone level 0.5083143136615464 0.1072265706960348 0.914609236578788 1.0 1.0 2 O14654 1 +Skin plaque 0.3433038964548833 0.1038137784353558 0.9173171319431196 1.0 1.0 5 Q06136 1 +Syringomyelia 0.4915198956294666 0.1016805565628755 0.9190102357601136 1.0 1.0 3 P35222,O60341 2 +Abnormal circulating protein concentration 0.3039910779999324 0.1007383558873359 0.9197581626384616 1.0 1.0 144 P14174,Q14C86,P02545,O43772,Q9BUK6,P39210,Q13586,O43707,P34949,Q9Y584,Q8NFF5,Q08J23,Q96BR5,Q9BPX6,Q8N511,Q9Y487,P43243,O14979,P36551,Q9Y5P6,P53985,Q5XKP0,Q07021,Q92734,P50570,O95831,P41440,P06753,P57740,Q8NFH4,Q14126,Q16836,Q8NAT1,Q9BT22,Q9NWM8,Q15149,P22626,Q8N1F7,P10253,P07196,P23786,O43505,Q12769,P50402,Q5JRX3 45 +Absent eyebrow 0.3336124162475308 0.1002444302161665 0.9201502734255176 1.0 1.0 6 P02545 1 +Scaling skin 0.3194804368301837 0.0996201898569282 0.9206458643727332 1.0 1.0 8 P02545 1 +Bilateral microphthalmos 0.3326318157802275 0.0978742370837413 0.9220321575749012 1.0 1.0 6 Q9UHX1 1 +Widely spaced teeth 0.2687031238958685 0.0978346086917294 0.9220636254357546 1.0 1.0 28 P51812,P16278,Q15233 3 +Abnormality of blood circulation 0.2418252082769004 0.0973085612885252 0.9224813573434764 1.0 1.0 67 P50570,P04062,Q969G3,P02545,Q9Y487,P21964,P23786,O75844,P46100,Q9UHX1 10 +Absent toe 0.272157974384248 0.096900607759419 0.9228053261577722 1.0 1.0 21 Q9UGU0,P02545,Q9H3P2,Q7LGA3,Q9UHX1 5 +Decreased circulating antibody level 0.2730608227200511 0.0954080493332339 0.9239907228026348 1.0 1.0 44 P00813 1 +Abnormality of tibia morphology 0.293907306256834 0.0953829471231155 0.924010660542106 1.0 1.0 12 O95831,Q32P28 2 +Paraplegia paraparesis 0.249568320068485 0.0953677552743698 0.9240227268782188 1.0 1.0 76 O95831,P35637,Q9H6K4,P07942,Q13510,P00846,Q96CU9,P56589,P46100,Q6DKK2,P04062 11 +Abnormal arachnoid mater morphology 0.3204552638958781 0.0952062996245572 0.924150966342172 1.0 1.0 7 Q9UHX1 1 +Abnormal labia majora morphology 0.3130926926540345 0.090045205009139 0.9282512923054071 1.0 1.0 9 O60885,Q9Y619,P16435,Q9UQE7 4 +Hypoplastic labia majora 0.3130926926540345 0.090045205009139 0.9282512923054071 1.0 1.0 9 O60885,Q9Y619,P16435,Q9UQE7 4 +Connective tissue nevi 0.4913596348223 0.087366832621097 0.9303799322754156 1.0 1.0 2 Q6NUK1 1 +Cutaneous finger syndactyly 0.4913596348222984 0.0873668326210953 0.9303799322754168 1.0 1.0 2 Q9Y619 1 +Food allergy 0.3621117121771512 0.0862333610880494 0.9312809111595008 1.0 1.0 4 Q01082,O95394 2 +Scleroderma 0.3345360249162682 0.0859636295911771 0.9314953295446324 1.0 1.0 5 P02545 1 +Abnormal echocardiogram 0.4784735812132945 0.0852564383884312 0.9320575225176976 1.0 1.0 3 P49748,P12235 2 +Hypersomnia 0.4858167590479191 0.0815776623070945 0.9349825649738776 1.0 1.0 2 O00170 1 +Abnormality of amino acid metabolism 0.4841865014672269 0.0799389066939024 0.9362858457604512 1.0 1.0 2 P18074 1 +Abnormality of the thyroid gland 0.2665414631893765 0.0789420302096521 0.9370787322628652 1.0 1.0 98 Q969G3,P02545,P61978,P03915,P21964,P00813,P21912,Q13423,P00403,P20585,P42892,P48735 12 +Palpebral edema 0.3306135770235083 0.0784156914956304 0.9374973919564678 1.0 1.0 5 O00170,Q12756,Q01082,Q14331 4 +Abnormal lacrimal duct morphology 0.3306135770235051 0.0784156914956242 0.9374973919564726 1.0 1.0 5 P48651,Q13428,Q9NX24,Q9UQE7 4 +Reduced tendon reflexes 0.3161673698515522 0.0780698163883499 0.9377725169252578 1.0 1.0 165 Q9NR77,O43819,P51114,P04062,O95721,Q8TD16,P02545,Q9BUK6,Q16637,P39210,P00846,Q13586,Q96BR5,Q10713,O00592,P07602,P40855,P35637,O75381,Q15067,Q13510,O14979,Q9Y5P6,Q9UBB4,P50336,P50570,O95831,P41440,P06753,Q9H6K4,P56589,Q9NSE4,Q8NAT1,Q9H4A3,Q8TAA9,P54802,Q96F07,Q13217,P61978,P03915,P10253,P07196,O43505,P50402,Q9BQT8,Q99720,O43681 47 +Prematurely aged appearance 0.2710934190931455 0.0763098014670169 0.9391726281403232 1.0 1.0 40 Q13126,P02545,Q9Y487,O75844,Q03252 5 +Abnormal enchondral ossification 0.2596236343847167 0.0752496320429078 0.9400160956024912 1.0 1.0 24 P40855,O75381,P56589,Q9UG56,Q96HY6,O96028 6 +Delayed social development 0.3526916802610041 0.0718039404258646 0.9427579369111556 1.0 1.0 4 Q9UJX6,Q13509,Q9Y2V7 3 +Clubbing of toes 0.475383110531459 0.0715799921023728 0.9429361632132368 1.0 1.0 2 Q9BXW9 1 +Pyridoxine responsive sideroblastic anemia 0.475383110531459 0.0715799921023728 0.9429361632132368 1.0 1.0 2 Q9BXW9 1 +Duodenal stenosis 0.475383110531459 0.0715799921023728 0.9429361632132368 1.0 1.0 2 Q9BXW9 1 +Generalized joint laxity 0.2871118479394998 0.0714528023326715 0.9430373867766646 1.0 1.0 12 Q9Y487 1 +Curly eyelashes 0.3268519983400141 0.0714316888334699 0.943054189975222 1.0 1.0 5 O60885,Q9UQE7 2 +Acne inversa 0.4747310074991806 0.0709931494201595 0.9434032077058344 1.0 1.0 2 Q92542 1 +Microdontia 0.2617336700065081 0.0709593177543583 0.9434301335629603 1.0 1.0 23 Q9Y487 1 +Abnormality of fibula morphology 0.291306674378473 0.0679062727901512 0.9458602453175556 1.0 1.0 11 O75431,Q96HY6 2 +Neoplasm of head and neck 0.3077425677883057 0.066442923272928 0.9470251978519596 1.0 1.0 8 P21912,P04637,Q8N9N2,P07954,P25054,P42224,P31040 7 +Thoracic kyphosis 0.2724805405769469 0.0659176909531913 0.9474433558713398 1.0 1.0 16 O95831,Q9UHX1 2 +Chronic otitis media 0.2590957358316972 0.06536160557875 0.9478860929918264 1.0 1.0 25 P21964 1 +Fulminant hepatic failure 0.3474714518760158 0.0643748625547579 0.94867174527592 1.0 1.0 4 Q16836,P98170,Q96RP9 3 +Abnormal heart valve physiology 0.2507500472826649 0.0643119286739009 0.948721855410566 1.0 1.0 81 P53701,Q15233,P04062,P16278,P02545,O60826,O75431,O00459,P00813,P51812,O75844,P55263,P46100,Q9UHX1 14 +Abnormality of macular pigmentation 0.4585779517286272 0.063684706338735 0.949221282598732 1.0 1.0 3 P35221,Q9UM00 2 +Aplasia hypoplasia involving bones of the lower limbs 0.2480653970866901 0.0634092596331022 0.9494406139703409 1.0 1.0 78 Q9UGU0,Q7Z4L5,O95831,P02545,O75431,Q13510,P00813,Q96HY6,Q03164,Q08J23,Q7LGA3,Q9UHX1 12 +Encephalocele 0.2898866428578909 0.0633237769296374 0.9495086825040332 1.0 1.0 11 Q9Y5P6,P07942,O43505,Q10713 4 +Delayed eruption of primary teeth 0.4656015650472701 0.0632307383468654 0.9495827680844398 1.0 1.0 2 Q13045 1 +Esophageal neoplasm 0.3076420640104496 0.0619379400128387 0.950612253723918 1.0 1.0 7 P21912,Q8N9N2,P25054,P31040,P42224,P07954 6 +Aplasia of the uterus 0.3166829905321631 0.0619337103417249 0.9506156220464764 1.0 1.0 6 Q9Y5S9,O95202,P30153,Q8IY37,O96028 5 +Papilledema 0.2645377618936947 0.0610456362981189 0.9513228642925332 1.0 1.0 21 Q969G3,Q7LGA3,P04062 3 +Abnormality iris morphology 0.2433617518178296 0.060118952933066 0.952060895006954 1.0 1.0 73 Q9NR77,P78318,P40855,Q96EK5,P53701,Q10713,O60826,O75381,O43505,P56589,P41227,P21912,Q9Y5P6,Q8NAT1,Q9H3P2,Q7LGA3,Q9UHX1,O96028 18 +Broad philtrum 0.2885145085561211 0.0589500957200194 0.9529918567837128 1.0 1.0 11 O14497,Q969G3,Q01082,Q92785 4 +Peters anomaly 0.4600586892729041 0.0589188776624017 0.9530167219705858 1.0 1.0 2 P49454 1 +Auditory hallucinations 0.4600586892729 0.0589188776623987 0.9530167219705884 1.0 1.0 2 P18583 1 +Hypopigmented macule 0.4521292964806632 0.0575580354627778 0.9541006770733612 1.0 1.0 3 Q15233 1 +Calcific stippling 0.4574502771437836 0.0569909799054203 0.954552380456792 1.0 1.0 2 O15228 1 +Elevated hepatic transaminase 0.2634326970824417 0.0565749412720867 0.9548837965325369 1.0 1.0 97 P28070,P35670,Q8N511,O43772,P23786,P39210,Q15067,Q13510,P22695,O75431,Q6NUQ1,P55263,P46100,Q16625 14 +Abnormal metabolism 0.2634452053069303 0.0562041012846038 0.955179213976858 1.0 1.0 50 P46977,Q9Y487,Q8N511,P41440 4 +Dilated fourth ventricle 0.2677182611666233 0.0551798466828141 0.9559951844872214 1.0 1.0 40 Q969G3,O60826,Q9Y487,O14936,Q99567,P23786,O43505,Q8NAT1,Q10713,P07437 10 +Vertebral wedging 0.4548418650146658 0.055126358306332 0.956037797176664 1.0 1.0 2 Q96AY3 1 +Panhypopituitarism 0.4545158134985311 0.0548976743999595 0.9562199846468185 1.0 1.0 2 Q8N3U4 1 +Abnormal dura mater morphology 0.4545158134985311 0.0548976743999595 0.9562199846468185 1.0 1.0 2 Q8N3U4 1 +Cyclopia 0.4545158134985311 0.0548976743999595 0.9562199846468185 1.0 1.0 2 Q8N3U4 1 +Median cleft lip 0.4545158134985311 0.0548976743999595 0.9562199846468185 1.0 1.0 2 Q8N3U4 1 +Abnormal 3rd finger morphology 0.4545158134985297 0.0548976743999587 0.9562199846468192 1.0 1.0 2 Q9Y3E5 1 +Heterotropia 0.2600643944266941 0.0545159797230097 0.9565240775437858 1.0 1.0 53 Q5KU26,Q15233,P55795,Q9NSE4,O43924,P46100,Q9UHX1 7 +Hypomimic face 0.2936675126561725 0.0521730838968353 0.9583907796541068 1.0 1.0 10 Q15043,P04062 2 +Abnormal b cell subset distribution 0.4448793215916344 0.0511542215556589 0.9592026299591192 1.0 1.0 3 P50851,P17812 2 +Diastema 0.2997475187302165 0.0509889011149336 0.9593343646720184 1.0 1.0 9 P46100 1 +Skeletal dysplasia 0.2668226832970357 0.0497426013196038 0.9603275075163222 1.0 1.0 41 Q7Z4L5,O95831,P16278,O75381,P56589,Q96HY6,P10619 7 +Large basal ganglia 0.2672667190711884 0.0482996854520814 0.9614774052357488 1.0 1.0 17 Q08J23 1 +Severely reduced visual acuity 0.4440821649820617 0.0480793260797721 0.9616530225462008 1.0 1.0 2 P35222 1 +Branchial anomaly 0.2985978519313021 0.0478260665941559 0.96185486218446 1.0 1.0 9 P61978 1 +Prolonged bleeding following procedure 0.4427779589175047 0.0472931467148341 0.96227959010209 1.0 1.0 2 P49257 1 +Depressed nasal tip 0.3121327892688702 0.0464863779626622 0.9629225911604083 1.0 1.0 5 Q03164 1 +Immunodeficiency 0.2484430136211893 0.0462376785099537 0.963120811467882 1.0 1.0 60 P14174,P21964,P09601,Q96A33,P00813,P21912,P46100,Q03252 8 +Chorioretinal hypopigmentation 0.4385392892076928 0.0448353875937683 0.9642385182223792 1.0 1.0 2 Q9Y619 1 +Hyperparathyroidism 0.4366586847517748 0.0444922481315549 0.9645120309546986 1.0 1.0 3 P53680 1 +Primary hyperparathyroidism 0.4366586847517748 0.0444922481315549 0.9645120309546986 1.0 1.0 3 P53680 1 +Oculogyric crisis 0.2836538638937279 0.0438895663542799 0.9649924321310964 1.0 1.0 11 Q01105 1 +Cerebellar cyst 0.2652925251397872 0.0438142776164824 0.96505244612164 1.0 1.0 37 Q969G3,O60826,Q9Y487,P23786,Q99567,O43505,Q8NAT1,Q9NQT5,P07437 9 +Abnormally low pitched voice 0.3075416258570103 0.0435715867134119 0.965245900698224 1.0 1.0 6 O60885,Q14683,Q9UQE7,O75530,Q15022 5 +Abnormal carotid artery morphology 0.2730846213509136 0.0435576138516507 0.965257038854466 1.0 1.0 13 P02545 1 +Abnormal morphology of the olfactory bulb 0.3305057096247945 0.0429534183341855 0.965738666339348 1.0 1.0 4 Q14683,Q13509,Q8N3U4 3 +Broad alveolar ridges 0.4334637964774732 0.0420695294805099 0.966443270609127 1.0 1.0 3 A1X283,Q9UBM7 2 +Retinopathy 0.2589838039214027 0.0398421428736938 0.9682189777339214 1.0 1.0 29 O43819,Q9NYB0,O96028,P00846,O75306,Q9H3P2,P07437 7 +Specific learning disability 0.2373487679122767 0.0394603645632774 0.9685233533844976 1.0 1.0 65 Q96EK5,P53701,P35637,Q9BVA1,P21964,Q9H6K4,P03915,P00403,Q9BPX6 9 +Short 1st metacarpal 0.3074412532637154 0.0393252928346244 0.968631041443992 1.0 1.0 5 O60885,Q14683,Q9NVI1,Q9UQE7 4 +Splanchnic vein thrombosis 0.4268014346266672 0.038769566084917 0.9690741093299382 1.0 1.0 2 P35222 1 +Portal vein thrombosis 0.4268014346266672 0.038769566084917 0.9690741093299382 1.0 1.0 2 P35222 1 +Epigastric pain 0.4268014346266672 0.038769566084917 0.9690741093299382 1.0 1.0 2 P35222 1 +Abnormal periventricular white matter morphology 0.2642048065853545 0.0375371890637581 0.9700566884452596 1.0 1.0 37 O75503,P07602,Q9UHX1,O15121 4 +Megalencephaly 0.4270622679349983 0.0374862225616837 0.9700973252297382 1.0 1.0 3 O00459 1 +Congenital bilateral hip dislocation 0.4238669709814137 0.0374137947733273 0.9701550737333968 1.0 1.0 2 Q9Y4R8 1 +Abnormal urine alpha ketoglutarate concentration 0.3036238981390864 0.0362027686033289 0.971120678412034 1.0 1.0 6 Q9UDR5,P21281,P21912,P09622,P00367 5 +Abnormal consumption behavior 0.2588197060593048 0.0357945975715288 0.9714461408216684 1.0 1.0 21 Q969G3,O14497,P35610,P49366,Q92785,Q4J6C6 6 +Decreased specific antibody response to protein vaccine 0.419302249755446 0.0354250129947793 0.9717408397407504 1.0 1.0 2 P17812 1 +Poor motor coordination 0.2703470802265878 0.0346097196559787 0.9723909509797132 1.0 1.0 13 P35670,O75503,Q10713 3 +Abnormality of facial musculature 0.2449880060771558 0.0339123387656582 0.9729470539361752 1.0 1.0 78 Q9BUK6,Q15043,P16219,Q9UHX1,O00592,P40855,O75381,Q92796,Q13510,P50570,P06753,P56589,P51812,Q969G3,P10253,P07196,Q00577,Q9BQT8,P04062 19 +Postnatal growth retardation 0.2449944958364306 0.0328129497942598 0.9738237513318038 1.0 1.0 61 Q969G3,P33991,P02545,Q9Y487,O75431,P46100,Q08J23,Q03164 8 +Decreased specific antibody response to vaccination 0.4194390084800811 0.0324835635180195 0.9740864235253748 1.0 1.0 3 P50851,P17812 2 +Butterfly vertebrae 0.4118030648842527 0.0324597928844742 0.9741053797504302 1.0 1.0 2 Q8N3U4 1 +Bone spicule pigmentation of the retina 0.3010145355642032 0.0314610089509408 0.9749018870905106 1.0 1.0 6 Q8WWY3,Q9UG56 2 +Abnormality of the common coagulation pathway 0.2631751227495862 0.0309275841356578 0.9753272914824404 1.0 1.0 14 P06748,P10644,P23526,Q6UN15,P49257,Q7L590,Q02750,P40763,P38435,P34949,Q14980,P98170,Q4KMQ2 13 +Deep set nails 0.4069122921421553 0.0307165129290124 0.9754956219632808 1.0 1.0 2 Q15022 1 +Hypoplasia of the ear cartilage 0.4165264424896521 0.0306981624582915 0.97551025661912 1.0 1.0 3 P57740 1 +Cerebral cortical atrophy 0.2581955154611516 0.0302284855821084 0.9758848306984064 1.0 1.0 94 Q5KU26,Q9UGU0,Q8TD16,O75503,P03915,O14936,Q9UPT5,P00846,P51812,Q9NSE4,P00403,O43924,P46100,Q16625,Q7LGA3,P04062 16 +Restrictive behavior 0.3184339314845058 0.030147967711857 0.9759490453969044 1.0 1.0 4 Q14683,Q01082,P51608 3 +Amblyopia 0.2628477900068343 0.0293037960896928 0.9766222993621504 1.0 1.0 15 P53701 1 +Abnormal muscle glycogen content 0.317345005945221 0.0290881348342414 0.9767942988257314 1.0 1.0 4 Q9BUK6 1 +Respiratory failure requiring assisted ventilation 0.316791286707764 0.028555111909743 0.9772194129778572 1.0 1.0 4 P10253 1 +Abdominal obesity 0.4112850619699827 0.0276542068810181 0.9779379473356512 1.0 1.0 3 O00170,O75312 2 +Abnormal nervous system electrophysiology 0.318244422156483 0.0274573453625132 0.9780949604786388 1.0 1.0 176 Q9NR77,P20700,Q13885,P02545,P21964,O14936,P39210,Q96A33,P49366,Q08J23,P07602,P40855,Q14108,O75381,P17480,P09471,Q15067,P50897,Q9Y5P6,Q9UBB4,P48449,O96028,P50570,O95831,O75503,Q8NBU5,Q13813,P56589,Q9NSE4,P00403,Q9H4A3,O15121,O14773,Q3ZCQ8,Q96F07,P03915,P07196,Q96N66,Q00577,Q9UBX3,Q99720,O43681 42 +Abnormality of the thoracic cavity 0.2619666917210801 0.026908944848044 0.9785323591448848 1.0 1.0 14 Q969G3,O15460 2 +Toe clinodactyly 0.2522943390535672 0.0263210116062272 0.9790012958778216 1.0 1.0 23 P51812,Q92796,Q7LGA3 3 +Thin nail 0.407045009784726 0.0253459310943668 0.9797790379694842 1.0 1.0 3 Q9H1A4,Q15022 2 +Esophageal carcinoma 0.4067188519243271 0.0251739389951801 0.979916224036087 1.0 1.0 3 P25054,Q8N9N2 2 +Distal arthrogryposis 0.40522672125416 0.024397077059192 0.980535879801974 1.0 1.0 3 Q96A33 1 +Oroticaciduria 0.3844147375285276 0.0243939109027055 0.980538405277734 1.0 1.0 2 Q9Y619 1 +Jaundice 0.2579432653407072 0.0236700393569844 0.9811158044370396 1.0 1.0 51 P35670,P40855,Q15904,O75381,O14936,P39210,P56589,P36551,P00374,Q6NUQ1,O15118,Q16625,Q01082 13 +Renal tubular atrophy 0.3112561174551423 0.0234425459895388 0.9812972675283962 1.0 1.0 4 Q96AX1,P57740,Q8WUM0 3 +Hydrops fetalis 0.2622633614110062 0.0232710471232732 0.981434066506074 1.0 1.0 39 P10619,O96000,P16278,Q13510 4 +Blistering by anatomical location 0.3736550374959229 0.0222081672719716 0.9822819026574924 1.0 1.0 2 Q15149 1 +Acral blistering 0.3736550374959229 0.0222081672719716 0.9822819026574924 1.0 1.0 2 Q15149 1 +Tibial torsion 0.3681121617215539 0.0212580607514016 0.9830397989438256 1.0 1.0 2 Q9Y5S9 1 +Aplasia hypoplasia of the sacrum 0.3985309586662406 0.0211080059327366 0.983159498507939 1.0 1.0 3 P04066 1 +Generalized dystonia 0.3671340071731359 0.0211017553271175 0.9831644846590788 1.0 1.0 2 O60220 1 +Falls 0.2890246197352298 0.0200827808824237 0.983977336241518 1.0 1.0 8 P21912,Q9BQT8 2 +Phthisis bulbi 0.3073409461663967 0.0200583446851332 0.9839968295794388 1.0 1.0 4 O60885,Q14683,Q9UQE7 3 +Tip toe gait 0.3514835343984344 0.0190126572368586 0.9848310082204405 1.0 1.0 2 O75477 1 +Increased c peptide level 0.3472448646886206 0.0185653998112651 0.9851878050269348 1.0 1.0 2 Q16836 1 +Hypoplasia of the olfactory bulb 0.3302901858493621 0.0171801551987483 0.9862928937111072 1.0 1.0 2 Q13509 1 +Hyperorality 0.3182262797522046 0.0165106776707063 0.9868269837003488 1.0 1.0 2 Q14203 1 +Phocomelia 0.3081186827518792 0.0161019961649557 0.9871530210128124 1.0 1.0 2 Q9Y5S9 1 +Foot oligodactyly 0.3081186827518741 0.0161019961649554 0.9871530210128128 1.0 1.0 2 P25054 1 +Abnormal qrs complex 0.3055102706227621 0.0160150588486762 0.987222378011868 1.0 1.0 2 Q9BTV4 1 +Aplasia cutis congenita over the scalp vertex 0.3025758069775062 0.0159252384898663 0.9872940351508804 1.0 1.0 2 Q15149 1 +Congenital localized absence of skin 0.3025758069775062 0.0159252384898663 0.9872940351508804 1.0 1.0 2 Q15149 1 +Recurrent staphylococcus aureus infections 0.2751874796217868 0.0153972141285122 0.9877152859675332 1.0 1.0 2 O95394 1 +Recurrent staphylococcal infections 0.2751874796217868 0.0153972141285122 0.9877152859675332 1.0 1.0 2 O95394 1 +Long palm 0.3833285787405698 0.0147579959240897 0.9882252503256876 1.0 1.0 3 P16435 1 +Neonatal alloimmune thrombocytopenia 0.3832354859752095 0.014723573452987 0.9882527125001236 1.0 1.0 3 Q9Y3Z3,P55265 2 +Csf lymphocytic pleiocytosis 0.3832354859752095 0.014723573452987 0.9882527125001236 1.0 1.0 3 Q9Y3Z3,P55265 2 +Chronic lymphatic leukemia 0.3832354859752095 0.014723573452987 0.9882527125001236 1.0 1.0 3 Q9Y3Z3,P55265 2 +Csf pleocytosis 0.3832354859752095 0.014723573452987 0.9882527125001236 1.0 1.0 3 Q9Y3Z3,P55265 2 +Chilblains 0.3832354859752095 0.014723573452987 0.9882527125001236 1.0 1.0 3 Q9Y3Z3,P55265 2 +Rheumatoid factor positive 0.3004893964110962 0.0145823754601794 0.988365360104594 1.0 1.0 4 Q05655,Q13546,O95394 3 +Alternating esotropia 0.3798080382939426 0.0134917362544375 0.9892354785173144 1.0 1.0 3 P20700 1 +Esophageal stenosis 0.2902383284361826 0.0132747644741156 0.9894085814475764 1.0 1.0 6 P01889,O95453,Q9NX24,O95394,O60832 5 +Abnormality of cardiovascular system electrophysiology 0.2669484258428787 0.0126464640744672 0.9899098505250208 1.0 1.0 107 P02545,O43772,P00846,P41227,P21912,P42892,P46100,Q8NFF5,O15460,P07602,P40855,O75381,P36551,Q9Y5P6,P06753,P56589,P00403,Q14BN4,P53701,Q07954,P03915,P10253,P23786,P06280,P50402,P04062 26 +Hypoplasia of the brainstem 0.2534342138945347 0.0120698390897949 0.9903698955600112 1.0 1.0 29 Q96EK5,Q13885,P07942,O14936,O43505,Q9UPT5,Q10713,P07437 8 +Spastic paraparesis 0.2568150213335121 0.012046415584952 0.9903885834542404 1.0 1.0 18 Q9H6K4,Q6DKK2,P04062 3 +Abnormal odontoid tissue morphology 0.2603889589518876 0.0116523116888759 0.9907030107914968 1.0 1.0 43 P53701,P21964,P16278 3 +Mitral valve prolapse 0.2557247011210111 0.0114109751058395 0.9908955567219022 1.0 1.0 19 P53701,P55795 2 +Abnormal uterus morphology 0.2478975977190785 0.011016852046174 0.991210001652592 1.0 1.0 25 P51812,P21912,P78549 3 +Stereotypical hand wringing 0.2933115823817299 0.0094290322747776 0.9924768322014156 1.0 1.0 4 Q14683,P20700,P51608 3 +Fatigable weakness of skeletal muscles 0.2837886855217442 0.0085835324075196 0.9931514161122108 1.0 1.0 8 Q9Y5P6,Q13586,P06753 3 +Esophageal stricture 0.2913539967373605 0.0081228914582253 0.993518941587997 1.0 1.0 4 P01889,Q9NX24,O95394 3 +Nasal speech 0.259184492751178 0.0073826088667707 0.9941095838742796 1.0 1.0 38 Q9UGU0,P06753,Q9Y487,P21964,Q7LGA3,Q15233,Q4J6C6 7 +Acute coronary syndrome 0.2555569623374265 0.0056167908774434 0.9955184728417654 1.0 1.0 17 O75844,P06280,P02545 3 +Multicystic kidney dysplasia 0.2556308573455722 0.0051260266384006 0.9959100403983618 1.0 1.0 16 P40855,O75381,P56589 3 +Stenosis of the external auditory canal 0.2847813404370432 0.0049119980972672 0.9960808083157004 1.0 1.0 6 P16435 1 +Ecchymosis 0.2759071592023541 0.0043084281702673 0.9965623823167792 1.0 1.0 10 P06748,Q9Y3A5,P10644,Q6UN15,P27797,P38435,O00170,Q14980,P04062 9 +Gangrene 0.2759071592023472 0.0043084281702506 0.9965623823167924 1.0 1.0 10 P49327,P06748,P10644,Q6UN15,P01889,P52732,O15460,Q14980,Q9NZ08 9 +Pelvic girdle muscle weakness 0.281621063614157 0.0040116877021378 0.9967991449052712 1.0 1.0 8 O14979 1 +Rotary nystagmus 0.2825448613376851 0.0027453419756011 0.9978095367750954 1.0 1.0 4 Q5T8D3,Q9Y4R8,O94905 3 +Gray matter heterotopia 0.2474444757429737 0.0022259300321508 0.9982239662605576 1.0 1.0 26 Q2TAA5,P61978,Q9BVA1,P07942,O43505,Q9Y5P6,Q9UEY8,Q86XL3 8 +Single naris 0.3303979125896888 0.0020545284843916 0.9983607245958284 1.0 1.0 3 Q14683,Q8N3U4 2 +Multiple enchondromatosis 0.2825023977231018 0.0015852372480898 0.99873516420429 1.0 1.0 6 Q13428,P48735 2 +Enchondroma 0.2800459258794532 0.0013285733100974 0.998939952179828 1.0 1.0 9 Q13428,P48735,O75874 3 +Skin erosion 0.279198253392601 0.000920049400266 0.999265906891919 1.0 1.0 7 O75844,P50336,P02545 3 +Neoplasm of the pituitary gland 0.2535582912871703 0.0004177224554741 0.9996667057117694 1.0 1.0 14 Q969G3,P48735,Q12824,O75874 4 +Metrorrhagia 0.2754569190600623 0.0001975538790291 0.9998423748110212 1.0 1.0 5 Q6UN15,P06748,Q14980,P10644 4 +Diffuse alveolar hemorrhage 0.2754569190600623 0.0001975538790291 0.9998423748110212 1.0 1.0 5 Q6UN15,P06748,Q14980,P10644 4 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cdeb5df7c7394d5254c31bb38d3a3ca837252121 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal bowel sounds", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal coccyx morphology", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger flexion creases", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemidiaphragm morphology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal right ventricular function", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical adenoma", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid nose", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Chin with horizontal crease", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Choroideremia", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic myelogenous leukemia", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Compensatory head posture", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical incisor", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crossed fused renal ectopia", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystathioninemia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum complement c4", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Eeg with spike wave complexes 2 5 3 5 hz", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg myotonic discharges", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal ulceration", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Folliculitis", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu recurvatum", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonadotropin deficiency", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematemesis", "Hematochezia", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemophagocytosis", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensibility of the knee", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermagnesiuria", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the fundus", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypoglycorrhachia", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Imbalanced hemoglobin synthesis", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Inappropriate sexual behavior", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal bleeding", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular acetabular roof", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "Ivory epiphyses", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited knee extension", "Limited wrist extension", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low plasma citrulline", "Low posterior hairline", "Low self esteem", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Miosis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic absence seizure", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuroma", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Palate fistula", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid dysgenesis", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dyskinesia", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Peg shaped maxillary lateral incisors", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Personality disorder", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postprandial hyperglycemia", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent coccyx", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protracted diarrhea", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged fingernail", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe b lymphocytopenia", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Silver gray hair", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowed slurred speech", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue neoplasm", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tibialis muscle weakness", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Uncontrolled eye movements", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral cleft palate", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zollinger ellison syndrome", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ANAPC1", "ANAPC2", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANXA11", "AP1B1", "AP1S2", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APPL1", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6IP1", "ARPC1B", "ARVCF", "ASAH1", "ASCC1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATG7", "ATIC", "ATP1A1", "ATP2A2", "ATP5A1", "ATP6", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "ATR", "ATRX", "ATXN10", "B4GAT1", "BAG3", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCKDHA", "BCKDK", "BCR", "BCS1L", "BICD2", "BLVRA", "BMS1", "BPTF", "BRAT1", "BRD4", "BUB1B", "BUB3", "C19orf70", "C1QBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAPN1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CCDC22", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC42", "CDC73", "CDH2", "CDK13", "CDK4", "CELF2", "CENPF", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD3", "CHD4", "CHD7", "CHD8", "CHM", "CHMP1A", "CHORDC1", "CISD2", "CIZ1", "CLASP1", "CLCN7", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT2", "CNP", "COA3", "COA7", "COG4", "COG6", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ5", "COQ8A", "COX15", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSC", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "CYFIP2", "DAG1", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DEGS1", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DICER1", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJC13", "DNAJC21", "DNAJC3", "DNM1", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTNBP1", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFNB1", "EFTUD2", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S3", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ESS2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOC8", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GBA", "GCDH", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GNA11", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2E2", "GTF2I", "GTPBP2", "GTPBP3", "GUF1", "GUSB", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HAX1", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2BP2", "IGF2R", "IMPAD1", "INF2", "INTS1", "IRF2BPL", "IRS4", "ITCH", "ITPA", "IVD", "JAGN1", "JAM3", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KMT2A", "L2HGDH", "LAMB1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD2", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPP", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LSS", "LYRM7", "MACF1", "MAGED2", "MAGT1", "MAN2B1", "MAP1B", "MAP2K1", "MAP2K2", "MAPK1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MESD", "MFF", "MFN2", "MGME1", "MIA3", "MICU1", "MID1", "MIF", "MIPEP", "MMAB", "MMADHC", "MOGS", "MORC2", "MPG", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTHFS", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MYH14", "MYH9", "MYO5A", "MYO6", "NAA10", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NARS2", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCDN", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEK9", "NELFA", "NEMF", "NF1", "NFKB2", "NFU1", "NHLRC2", "NHP2", "NNT", "NONO", "NOP56", "NPC1", "NPM1", "NR3C1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NTHL1", "NUBPL", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "OPTN", "OSGEP", "OTULIN", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PANX1", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDK3", "PDXK", "PEPD", "PEX14", "PEX16", "PEX19", "PEX3", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKB", "PICALM", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PISD", "PITRM1", "PKN1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "POMGNT2", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPP3CA", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCA", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RB1", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RFT1", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF213", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS28", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RREB1", "RRP7A", "RTN2", "RTN4IP1", "SAMHD1", "SAR1B", "SARS", "SARS2", "SBDS", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SDHA", "SDHB", "SEC23A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERAC1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", 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sha256:8a14b2afe87c3807a53e7912bd6dcd683240a149d5577d24708c3dd91ae7d104 +size 75324 diff --git a/msigdb_kegg/df_merge.tsv b/msigdb_kegg/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9202686d83c6ca859ed6ea6babb1a3f0bd1c2247 --- /dev/null +++ b/msigdb_kegg/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lysosome 24 50 3.223028066581269 0.0012684312451316 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 1.2052835194522655e-11 9.590098126685308e-05 3.8672341199252e-05 1.5260114285726894e-10 4.767288719826981e-12 +Porphyrin and chlorophyll metabolism 3 15 2.5142659766945963 0.0119280437453561 3.728155339805826 13.315533980582524 1.2215621624941897 0.2689555702886888 1.770547470360957 1.4201912411596824 1.0389071586082248 0.2908939383930566 0.000181485244219 0.0001055314719321 0.0008209706516698 0.0011461563975241 0.0142025885279179 +Abc transporters 3 6 2.3394416360877552 0.0193125888198713 2.3762135922330097 6.366504854368932 0.6645221155900782 0.3307647417699358 1.8079428939478197 2.1798157082242287 1.1702884010083077 0.2791394174824396 0.0343508900176433 1.0 0.172526836456327 0.0011461563975241 0.0142025885279179 +Sphingolipid metabolism 6 12 2.0924680712628745 0.0363966650367386 5.672330097087379 11.759708737864075 0.9805985471070467 0.1821702203806468 2.452838935293596 1.3449033287601222 1.7625559835482287 0.2542774311591588 0.3099309187147142 1.0 1.0 0.0211121130334516 0.0001346421108604 +Glycosaminoglycan degradation 2 6 2.0597789936822064 0.039419673644893 3.407766990291262 5.864077669902913 0.1350713234786387 0.1703873780123549 1.3379225542760151 0.7043353086258667 1.932540087143412 0.2532951180616937 0.0006228809854352 1.0 1.0 0.0025378182642571 0.0179235086559622 +Hypertrophic cardiomyopathy hcm 4 8 2.0527726180446373 0.0400946353623425 3.429611650485437 9.101941747572816 0.6486134300733651 0.4298239576137608 1.8675556020784376 1.719193792909202 1.0005513529453438 0.3180395638112931 1.0 1.0 1.0 1.0 0.1443540625367929 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..462abd8fa09ff76fdd949130ca68de1e13486946 --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 179, + "title": "Average number of proteins per term", + "value": 16.324022346368714 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b357a465028d026f4efedb6a9124a114299ec30e --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3f0b625b7ffe7986f2a2409b68f63427b592c996 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,62 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosome 0.6029663991462492 3.223028066581269 0.0012684312451316 0.2032332578939299 0.1135245964392829 50 Q93050,P11717,Q9Y2T2,P07602,Q14108,Q9Y487,P50897,Q13510,O75503,Q92572,O14773,P11117,P20645,Q99523,P54802,P16278,P06865,P10253,Q8NCC3,Q9UMR5,O15118,P10619,P04062,O43681 24 +Porphyrin and chlorophyll metabolism 0.6799675670554768 2.5142659766945963 0.0119280437453561 0.8832774942264117 0.3558533050697923 15 P30519,P09601,P22830 3 +Abc transporters 0.8656257633459856 2.3394416360877552 0.0193125888198713 0.9695226309302726 0.3881020247833265 6 O15439,Q03519,P08183 3 +Sphingolipid metabolism 0.657583485908751 2.0924680712628745 0.0363966650367386 0.998688420270304 0.4485587331162077 12 P16278,Q06136,Q13510,O15121,P04062,O43681 6 +Glycosaminoglycan degradation 0.8000425453259772 2.0597789936822064 0.039419673644893 0.9992526396006156 0.4485587331162077 6 P54802,P16278 2 +Hypertrophic cardiomyopathy hcm 0.7386988769338475 2.0527726180446373 0.0400946353623425 0.9993409976390584 0.4485587331162077 8 P50402,P16615,P02545,P06753 4 +Steroid biosynthesis 0.6175307923887818 1.771212638094827 0.0765253484321974 0.9999993527512188 0.5796367372568559 11 Q15392,Q15800,Q16850 3 +Oxidative phosphorylation 0.398421624286434 1.6819630463882036 0.0925760058675611 0.999999971943318 0.6201880883154477 60 Q9Y5K8,Q9UDW1,P25705,Q93050,O75964,Q9Y487,P03915,O43674,P00846,P22695,O43676,O96000,P21912,P00403 14 +Glycosphingolipid biosynthesis ganglio series 0.8119309083138972 1.676972170529905 0.0935479239358496 0.9999999768405742 0.6201880883154477 4 P16278 1 +Riboflavin metabolism 0.7333550913838432 1.61694649527391 0.1058898308166531 0.9999999980093488 0.6290650285597711 5 Q8NFF5,Q9NPH0,Q13614,P11117 4 +Renin angiotensin system 0.7946088759319365 1.6067163145282417 0.1081166131079869 0.9999999987260708 0.6290650285597711 4 Q9UIQ6 1 +Dilated cardiomyopathy 0.6195291696125402 1.5512498897300613 0.1208418104550952 0.9999999999027258 0.6290650285597711 9 P50402,P16615,P02545,P06753 4 +Peroxisome 0.4524769309185661 1.548118293675382 0.1215938184107319 0.9999999999165408 0.6290650285597711 35 Q9NR77,P40855,P34913,O14734,P33121,O75381,P39210,Q15067,Q13011,P56589,O15254,Q9BQG2,Q9UKU0,P48735,O75874 15 +Parkinsons disease 0.4113979088203902 1.5422965707787542 0.1230015418971619 0.9999999999373688 0.6290650285597711 53 Q9Y277,Q9UDW1,P25705,P03915,P00846,P22695,O43676,O96000,P21912,P00403,P45880,P21796 12 +Primary immunodeficiency 0.9442451907401426 1.4857342144304988 0.1373494369004573 0.9999999999967308 0.651608289223651 2 P00813 1 +Epithelial cell signaling in helicobacter pylori infection 0.4709925745944597 1.4552112372211885 0.1456107908879667 0.999999999999416 0.651608289223651 21 Q93050 1 +Cardiac muscle contraction 0.4654355781946 1.364704460107933 0.1723459572682251 0.999999999999998 0.703001851228263 20 Q9UDW1,P06753,O14949,P22695,P16615,P00403 6 +Other glycan degradation 0.6067004642835958 1.3417441659863238 0.1796789613484741 0.9999999999999996 0.7086757288059083 7 P16278,P06865,P04066,Q9BTY2,P04062 5 +Ecm receptor interaction 0.7051906940564094 1.240427466061918 0.2148173272276103 1.0 0.7437610612043399 4 P07942 1 +Vibrio cholerae infection 0.4362624203751393 1.19965537808999 0.2302732096577489 1.0 0.7437610612043399 21 Q93050 1 +O glycan biosynthesis 0.687009770171536 1.1657089901775837 0.2437321240929768 1.0 0.7437610612043399 4 Q86SF2,O43505 2 +Tight junction 0.3940843305090128 1.1045817853795776 0.2693408472206409 1.0 0.7437610612043399 41 P35579,P05771,P67870,Q96A65,O14936,Q13813,Q9UDY2,O60645,O43707,Q15334,Q07157,Q16625,P35580,P11802,P12814 15 +Proteasome 0.398611310568384 1.0925874794047337 0.2745749624807858 1.0 0.7437610612043399 36 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Antigen processing and presentation 0.4509007887420945 1.084088791285891 0.2783254321105293 1.0 0.7437610612043399 15 P10321,Q06323,Q03519,Q9UL46 4 +Progesterone mediated oocyte maturation 0.3940980513786296 1.027452733535016 0.304207331297611 1.0 0.756916934106505 25 Q9UJX4,Q9UJX3,O00459,P51812,Q15418 5 +Mtor signaling pathway 0.4822285520616318 1.0091235592534054 0.3129153805803428 1.0 0.756916934106505 11 P51812,Q15418,P23588 3 +Alpha linolenic acid metabolism 0.8158504163854583 0.9987944952492812 0.3178942532206623 1.0 0.7587076176866474 3 O15254 1 +Snare interactions in vesicular transport 0.4345039252667596 0.977285346952928 0.3284279053060768 1.0 0.761294038973312 15 O95249,Q86Y82,Q9P2W9 3 +Nicotinate and nicotinamide metabolism 0.5545865357429052 0.950917453626432 0.3416462809724776 1.0 0.7741099277730823 6 Q13423 1 +Glycosphingolipid biosynthesis globo series 0.7853881278538659 0.8900151603870159 0.3734577456866312 1.0 0.8093918574519237 3 P06865,P06280 2 +Allograft rejection 0.607478755401508 0.842670969222864 0.3994124876568259 1.0 0.8093918574519237 4 P10321 1 +Graft versus host disease 0.607478755401508 0.842670969222864 0.3994124876568259 1.0 0.8093918574519237 4 P10321 1 +Autoimmune thyroid disease 0.607478755401508 0.842670969222864 0.3994124876568259 1.0 0.8093918574519237 4 P10321 1 +Butanoate metabolism 0.3958546294855862 0.8292608840315125 0.4069567998361627 1.0 0.8093918574519237 19 Q9BWD1,Q9H9P8,P30837 3 +Retinol metabolism 0.5431055839825529 0.7900171612281652 0.4295177461082411 1.0 0.8179114526954804 5 O94788 1 +Huntingtons disease 0.3057555618549297 0.7655701485385527 0.4439321121807589 1.0 0.8277484175037068 74 Q9Y277,Q9UDW1,P25705,P00846,P22695,O43676,O96000,P21912,P00403,O00291,P45880,P21796 12 +Calcium signaling pathway 0.3847600243334019 0.7522593469609946 0.4518951102752679 1.0 0.8298295210654789 19 P45880 1 +Arrhythmogenic right ventricular cardiomyopathy arvc 0.410949892487044 0.7301381507313274 0.4653057435596572 1.0 0.8298295210654789 13 P02545,P50402,P16615,O43707,P12814 5 +Fatty acid metabolism 0.3566228858364185 0.7178273467420855 0.47286374943396 1.0 0.8298295210654789 30 P16219,P30837,O15254,P23786,Q9BWD1,Q9UKU0 6 +Amyotrophic lateral sclerosis als 0.4261795839538611 0.6195405451868969 0.5355603203257524 1.0 0.8483654631708822 10 P07196 1 +Tryptophan metabolism 0.3735618016381456 0.5890805770292595 0.5558072220691992 1.0 0.8651260239164056 15 Q9BWD1 1 +Viral myocarditis 0.3992846442293506 0.5484976871379894 0.5833502169375921 1.0 0.9001697313088707 11 P10321,P35580,P04439 3 +Long term potentiation 0.3641019942501192 0.5314242780872657 0.5951248012682524 1.0 0.907763256788009 15 Q15418 1 +Glycine serine and threonine metabolism 0.4302705031997991 0.5001606878153279 0.6169619367811825 1.0 0.907763256788009 7 P34897,O75600,P32929 3 +Tyrosine metabolism 0.4271110567824476 0.4862855025409142 0.6267647565808185 1.0 0.907763256788009 7 P21964 1 +Ppar signaling pathway 0.3535524744375211 0.4825159146146088 0.6294394957348741 1.0 0.907763256788009 16 Q9UKU0,P23786,O15254 3 +Pathogenic escherichia coli infection 0.3188448423666201 0.4500244018570298 0.6526928456176588 1.0 0.907763256788009 24 Q13885,Q9BVA1,Q16625,Q13464,P68371,P07437 6 +Biosynthesis of unsaturated fatty acids 0.3967600651114556 0.4176421510782172 0.676208773655794 1.0 0.907763256788009 9 O15254 1 +Thyroid cancer 0.377105343011303 0.3767037171517048 0.7063938001405439 1.0 0.9193487333331406 10 P12270,Q16204 2 +Gap junction 0.3264846775932611 0.3516997511428619 0.7250634472149575 1.0 0.9206894932153236 18 P05771,Q13885,Q9BVA1,P06493,P17252,Q07157,P29992,P62993,P68371,P07437 10 +Leukocyte transendothelial migration 0.3022965226160734 0.3337707753033483 0.73855253791919 1.0 0.9221693215480412 24 O60716,P05771,O00459,O43707,Q16625,P12814,Q13464 7 +Small cell lung cancer 0.3528581027007671 0.2680650824402495 0.7886492226563073 1.0 0.9348888136124436 10 P07942,O00459 2 +Type i diabetes mellitus 0.3849055062449537 0.2064287109838899 0.8364560456391832 1.0 0.9536664469389412 5 P10321 1 +Lysine degradation 0.2760001866320184 0.1659876490727703 0.8681666699505532 1.0 0.970133984183434 24 Q9BWD1 1 +Mismatch repair 0.2854017128409249 0.1196304366925134 0.9047759078699203 1.0 0.9775380621633272 16 P41440 1 +Dna replication 0.2711102437677157 0.1173992507775417 0.906543677760404 1.0 0.9775380621633272 27 P41440,P33991 2 +N glycan biosynthesis 0.2709346922110732 0.0579789069661731 0.95376543006069 1.0 1.0 14 Q2TAA5,P46977,Q9BT22,Q8TCJ2,P04843 5 +Aldosterone regulated sodium reabsorption 0.2834222315851915 0.043188828550367 0.9655510103059736 1.0 1.0 11 Q9Y3B8 1 +Nitrogen metabolism 0.3213703099510588 0.033083248835804 0.9736082009304758 1.0 1.0 4 O94925,P00367,P32929 3 +Alzheimers disease 0.2502760692668851 0.0329001121102433 0.9737542433944496 1.0 1.0 58 Q9UDW1,P25705,Q07954,O43674,P00846,P22695,O43676,O96000,P21912,P16615,P00403 11 +Apoptosis 0.2622238673088121 0.0276231226669557 0.9779627394790196 1.0 1.0 16 O95831,O00459 2 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7b514690a2ec6d8c62dae49ece0f7467db14126c --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "APPL1", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG7", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATR", "ATRX", "B4GAT1", "BAIAP2", "BCAS2", "BCAT2", "BCKDHA", "BCR", "BDH2", "BIRC6", "BLVRA", "BLVRB", "BNIP1", "BPNT1", "BUB1B", "BUB3", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CARS2", "CASK", "CBR1", "CCDC6", "CCNB1", "CD47", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDS2", "CETN2", "CFL1", "CFL2", "CHD8", "CHERP", "CHMP6", "CHORDC1", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "COMT", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DEGS1", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIS3", "DLAT", "DLD", "DLG1", "DLST", "DNA2", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK1", "DPM1", "DPYSL2", "DPYSL5", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "EMD", "ENAH", "ENDOD1", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERBIN", "ERCC2", "ERCC3", "ERO1A", "EXO1", "EXOC3", "EXOC4", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FOXO3", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLM", "GFPT1", "GGA1", "GGA2", "GGCT", "GGH", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GRB2", "GRHPR", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HADH", "HADHA", "HADHB", "HAGH", "HCCS", "HDAC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIP1", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2R", "IMPDH2", "IQGAP1", "IQGAP2", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JAM3", "JUP", "KARS", "KDSR", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LCLAT1", "LDHA", "LDHB", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LSM2", "LSM6", "LSS", "LTA4H", "LYN", "LYPLA1", "M6PR", "MAD2L1", "MAN2A1", "MAN2B1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MGST2", "MGST3", "MID1", "MIF", "MMAB", "MOGS", "MPG", "MPHOSPH6", "MPI", "MPST", "MPV17", "MRE11", "MRPL13", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTOR", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NARS2", "NBN", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NF1", "NFKB2", "NGEF", "NIT2", "NLN", "NME1", "NME2", "NNT", "NPC1", "NR3C1", "NSD2", "NSD3", "NSDHL", "NSF", "NT5C2", "NTHL1", "NUDT12", "NUDT5", "NUDT9", "OAT", "OCLN", "OGDH", "ORC3", "ORC5", "OXA1L", "P4HA1", "P4HA2", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PC", "PCBP1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PECR", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PHF5A", "PHGDH", "PHKB", "PIAS2", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKN1", "PLA2G15", "PLCG1", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLXNB2", "PMPCA", "PMVK", "PNP", "PNPT1", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "PPA1", "PPA2", "PPAT", "PPID", "PPIH", "PPIL1", "PPIL2", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTDSS1", "PTGES2", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QPRT", "RAB13", "RAB31", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAC1", "RAD21", "RAD23B", "RAD50", "RALA", "RALB", "RAPGEF2", "RARS", "RARS2", "RB1", "RBM17", "RBM22", "RBM25", "RBM8A", "RBMX", "RCOR1", "RDH11", "RDX", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RIPK1", "RNASEH2A", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRM1", "RRM2", "RUVBL1", "SAE1", "SARS", "SARS2", "SART1", "SCARB2", "SCP2", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEPHS1", "SETD1A", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC19A1", "SLC25A10", "SLC25A15", "SLC25A17", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC2A1", "SLC33A1", "SLC38A2", "SLIT2", "SLK", "SLTM", "SMC1A", "SMC3", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP29", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORD", "SORT1", "SPCS2", "SPCS3", "SPR", "SPTAN1", "SPTLC1", "SPTLC2", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRA", "SRPRB", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SYMPK", "TAB1", "TAF6L", "TALDO1", "TAP2", "TARS", "TARS2", "TARSL2", "TCERG1", "TECR", "TFAM", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TOLLIP", "TOMM40", "TP53", "TPI1", "TPM3", "TPM4", 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metabolism 7 12 2.3832996811622547 0.0171582199430035 6.563106796116505 14.388349514563108 0.750167459040055 0.1742505874253542 2.387954817808654 2.3973407990867264 1.8682770414846892 0.2409021330213527 0.0838566849413369 1.0 1.0 0.0864645508391317 0.2509343023197264 +Metabolism of porphyrins 2 10 2.350394456103599 0.0187535253268438 2.766990291262136 9.186893203883496 1.2638611374915407 0.2204767139400954 1.3861582272503026 1.170645435718008 1.0950295956895657 0.2541910601955712 0.0018241008785546 6.357667188483331e-05 0.000499833948772 0.007181114657122 0.046330877355434 +Heparan sulfate heparin hs gag metabolism 2 5 2.335750379889408 0.019504255102001 2.4320388349514563 4.83252427184466 0.8003221575390526 0.2230961855611341 1.2648123228701085 1.2708877857521428 1.4628061886044337 0.2633127679646707 0.0800553496797878 1.0 1.0 0.0403203385718549 0.2007579256502274 +Mitophagy 3 11 2.251970357803276 0.0243241452922742 3.662621359223301 11.783980582524272 1.3564301304992197 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9.495950625534562 1.0729913690397648 0.3929655478972317 0.044226868612068 0.1314977741365594 0.0405711576604341 0.1098380277170333 0.0055417771020742 +Binding and uptake of ligands by scavenger receptors 2 8 2.1065607733141976 0.0351556699811068 1.6286407766990292 7.286407766990291 0.4072923013026871 0.3929582954559311 1.6430066853321073 0.8979532869647183 1.127021484187218 0.2797911593020417 0.0253021270616913 0.0771453392642774 0.1486636480545473 0.0612683946998099 0.046330877355434 +Iron uptake and transport 3 18 2.0848978122868957 0.0370785773098689 4.089805825242719 17.9126213592233 1.0360420001787272 0.323786301352462 2.0477771422769826 0.9863810102632052 1.0014322629164618 0.2971986354372174 0.0022517422810863 2.837652512994501e-05 0.0004262582326702 0.0124805433688738 0.0092437434518958 +Gpcr ligand binding 2 9 2.05137200371224 0.0402307332996039 3.4611650485436893 9.330097087378642 1.051447004644797 0.2131328881138611 1.5951828582954857 1.3192992367203638 1.3003237502897853 0.2397874119507845 0.1466588182002048 0.019691222561341 0.0695193554582273 0.3017698240323906 0.3865751636037191 +Ion channel transport 9 29 2.020153700171435 0.0433674471287732 9.031553398058252 27.74271844660194 0.8980727715308076 0.3472480807052641 4.2752930421976005 3.4432740668393595 1.4212023690700646 0.3452897078102002 0.1198907862147021 0.0568079337981731 0.0073736270457285 0.0464749197460046 0.0173345468362617 +Regulation of mrna stability by proteins that bind au rich elements 15 64 2.007058711674787 0.0447434118428013 17.303398058252426 62.189320388349515 0.3637537395774206 0.6066390862029128 8.19973289328142 2.9201480419101515 1.0954480785949263 0.3602041660944462 0.1104025890289572 0.3121781622201707 0.5277430376784388 0.0027636692954349 4.710379327421361e-06 +Cholesterol biosynthesis 4 15 2.0056477452338664 0.0448938440342241 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 0.0050357755542779 0.1071891284628969 0.0014183751228366 0.0002206103540123 0.0007997701188881 +Resolution of d loop structures through synthesis dependent strand annealing sdsa 0 5 1.9956915911201727 0.0459675029388946 2.0242718446601944 7.264563106796117 0.1102873389811883 0.465949849674053 1.8193654083793276 2.44163055366299 1.0385932117537884 0.2998892330148265 1.0 1.0 1.0 0.4677029294328743 0.7255195214095727 +Resolution of d loop structures 0 5 1.9956915911201727 0.0459675029388946 2.0242718446601944 7.264563106796117 0.1102873389811883 0.465949849674053 1.8193654083793276 2.44163055366299 1.0385932117537884 0.2998892330148265 1.0 1.0 1.0 0.5398936447967271 0.7964232447631217 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 5 10 1.990385093182771 0.0465485307320494 2.808252427184466 8.344660194174757 -0.0367658334436417 0.47043079112258 1.6023738016949065 1.4573701647671262 1.0676278865531703 0.3078458831035016 0.0376070471641661 1.0 0.0163998244725808 0.0130923880875091 0.0027898710574492 +Protein protein interactions at synapses 8 16 1.987473603633993 0.0468699382410715 2.883495145631068 13.817961165048544 0.4737716009680486 0.554790031489885 2.134101165352059 2.1071693888824656 0.7224067510326084 0.2930215130485676 0.4950437749542066 1.0 0.3534667347825532 0.3017698240323906 0.0702989298923652 +Striated muscle contraction 4 5 1.986743385654426 0.0469508413068977 2.3932038834951457 5.325242718446602 0.6053303821705729 0.3904114603068206 1.4382947114128322 1.0455841909244117 1.143829865381849 0.3284891204761319 0.2112540265048064 1.0 0.1405588989726414 0.3214791435692521 0.1801322612125274 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 3 11 1.9721264316062108 0.0485951753047326 4.016990291262136 10.99757281553398 1.1239772251284714 0.2752182956921286 1.9514004604865949 1.181365809872934 1.0815649178051203 0.2865915409883788 0.0312118869909902 0.0035263772514821 0.0135177788357734 0.0746908244780269 0.0118045746321095 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5c87887749440cb478a3e7779284ffcfef79c387 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 1388, + "title": "Average number of proteins per term", + "value": 18.94884726224784 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..9a33800ceacc6864065770acbaed757f1bbd2634 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..340303d524412270918a76354893b12756bc4485 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,436 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein localization 0.5396849977164077 3.4829762325149636 0.0004958723861823 0.4976416532050131 0.0983244102887224 77 Q9NR77,Q8N4H5,Q99595,P25705,P39210,P46379,Q9NS69,Q9Y584,O60830,P21796,Q10713,Q9NX63,P40855,Q8N4Q1,O75381,P09601,Q13011,Q15067,O14925,P62072,Q8NBU5,O15254,O75431,P56589,Q3ZCQ8,P34913,O96008,P50402,Q5JRX3,Q13505,O43681 31 +Mitochondrial protein import 0.6138829606414747 2.866219505297683 0.0041540610103922 0.9969046236172252 0.3717151473580153 36 O14925,Q9NX63,Q8N4H5,Q99595,P25705,Q8N4Q1,P62072,O75431,Q5JRX3,Q9NS69,Q13505,Q9Y584,Q3ZCQ8,O60830,P21796,Q10713 16 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.7294247149930628 2.747237434722623 0.0060099608599448 0.9997675867651312 0.3717151473580153 14 Q13217,P07942,O43852,Q9BTY2,Q02818,Q86UP2,Q07065 7 +Sphingolipid metabolism 0.6145778116354355 2.728965498804753 0.0063533350586149 0.9998561243968068 0.3717151473580153 27 P07602,P10619,P16278,Q96G23,Q06136,P06865,Q13510,O15121,P27544,P04062 10 +Phase i functionalization of compounds 0.6849951993628185 2.543507022161823 0.0109745851020794 0.9999997771857037 0.3717151473580153 15 O43169,P07099,Q16850 3 +Activation of nmda receptors and postsynaptic events 0.5880878220320541 2.514384238866287 0.0119240441338595 0.9999999412538152 0.3717151473580153 24 Q13885,Q9BVA1,Q92796,O14936,P07196,P52292,P51812,Q12959,Q15418,Q14168,P68371,Q14012 12 +Cilium assembly 0.478832493780416 2.4986866848242015 0.0124654466690492 0.9999999725468094 0.3717151473580153 59 Q7Z4L5,Q9H6D7,Q13885,A0AVF1,Q7Z4H7,O60645,O43924,A6NIH7,P07437,Q9BVA1,P78371,P41208,Q92973,O95684,P68371,O94927,O75935,Q9UPT5,O43805,Q13561 20 +Pink1 prkn mediated mitophagy 0.8349973617268508 2.495916455941548 0.0125632186438682 0.999999976071862 0.3717151473580153 8 Q8N4H5,Q9NS69,P21796 3 +Mitochondrial calcium ion transport 0.6534409794662136 2.459505091192667 0.0139128724277837 0.9999999964155554 0.3941034067298735 17 Q8IYU8,Q8WWC4,Q9H4I9,P45880,P21796,Q9BPX6 6 +Assembly and cell surface presentation of nmda receptors 0.7400707993196722 2.421749402927326 0.015445997951498 0.999999999586492 0.4036543945913388 11 Q9BVA1,Q92796,O14936,P07196,Q12959,Q14168,P68371 7 +Glycosaminoglycan metabolism 0.7111320238473536 2.3832996811622547 0.0171582199430035 0.999999999963081 0.4036543945913388 12 P54802,P16278,Q8TB61,P06865,O43505,P15586,Q7LGA3 7 +Metabolism of porphyrins 0.754512577781388 2.350394456103599 0.0187535253268438 0.9999999999961272 0.4131167817208412 10 P30519,P22830 2 +Heparan sulfate heparin hs gag metabolism 0.9057144777547604 2.335750379889408 0.019504255102001 0.9999999999986614 0.4131167817208412 5 P54802,P16278 2 +Mitophagy 0.707233948404032 2.251970357803276 0.0243241452922742 0.9999999999999986 0.4338901782063409 11 Q8N4H5,Q9NS69,P21796 3 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.80082463866336 2.2504785096713564 0.0244185861964638 0.9999999999999988 0.4338901782063409 7 Q9NR77 1 +Glycosphingolipid metabolism 0.6273760751363278 2.248628497039608 0.0245361418055207 0.9999999999999988 0.4338901782063409 16 P07602,P16278,P06865,Q13510,P10619,P04062,O43681 7 +Class a 1 rhodopsin like receptors 0.8433494704938473 2.24543920702797 0.0247399508301255 0.9999999999999992 0.4338901782063409 6 P42892 1 +Peptide ligand binding receptors 0.8433494704938473 2.24543920702797 0.0247399508301255 0.9999999999999992 0.4338901782063409 6 P42892 1 +Slc mediated transmembrane transport 0.5483527005296023 2.236474888464392 0.025320680428468 0.9999999999999996 0.4338901782063409 26 P08195,Q8TB61,Q15043,Q8TAD4,Q99808,P30825,Q9H2J7,P36404,Q8NEW0,Q96QD8,P35613,P53985,Q9UBX3,Q9Y6M7,Q70HW3 15 +Organelle biogenesis and maintenance 0.4302791726423431 2.1366130441354203 0.0326294777854347 1.0 0.5157936049535805 89 Q7Z4L5,Q9H6D7,Q13885,P25705,A0AVF1,Q7Z4H7,Q16891,P00846,O60645,O43924,A6NIH7,Q10713,P07437,Q9NX63,Q9BVA1,P78371,P41208,Q92973,O95684,P68371,O75935,O94927,O75964,O75431,Q9UPT5,O43805,Q13505,P48735,Q13561 29 +Binding and uptake of ligands by scavenger receptors 0.7501269180932132 2.1065607733141976 0.0351556699811068 1.0 0.5203895640741424 8 Q07954,Q8WTV0 2 +Iron uptake and transport 0.5853616560242805 2.0848978122868953 0.0370785773098689 1.0 0.5343190909580331 18 Q93050,Q9Y487,P30519 3 +Gpcr ligand binding 0.7194225915762482 2.0513720037122396 0.0402307332996039 1.0 0.5584025781985024 9 P07602,P42892 2 +Heme degradation 0.9024891711184582 2.0382078396315384 0.0415291518192086 1.0 0.5656159968040053 4 P30519 1 +Ion channel transport 0.5172116763253012 2.020153700171435 0.0433674471287732 1.0 0.5844079282984205 29 P35670,Q9Y5K8,Q93050,Q9Y487,P16615,Q9HD20,Q9H4A3,P51790,Q9C0H2 9 +Regulation of mrna stability by proteins that bind au rich elements 0.4082655161832159 2.007058711674787 0.0447434118428013 1.0 0.5851042251232993 64 P28070,Q92945,Q14103,Q13868,Q5RKV6,O00231,Q01105,Q99436,P28072,Q06323,Q92973,Q9UL46,P28074,P49721,Q9NQT5 15 +Cholesterol biosynthesis 0.5951144085759082 2.0056477452338664 0.0448938440342241 1.0 0.5851042251232993 15 Q9BWD1,Q15800,Q15392,Q16850 4 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.6829492820892586 1.990385093182771 0.0465485307320494 1.0 0.5851042251232993 10 Q92796,P07196,P51812,Q15418,Q14168 5 +Protein protein interactions at synapses 0.5853111978506044 1.987473603633993 0.0468699382410715 1.0 0.5851042251232993 16 P10586,P41440,Q92796,O14936,Q96HC4,Q12959,O95197,Q14168 8 +Striated muscle contraction 0.8204960835509081 1.986743385654426 0.0469508413068977 1.0 0.5851042251232993 5 P08670,Q9NYL9,P67936,P06753 4 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.6544677822576566 1.9721264316062108 0.0485951753047326 1.0 0.5851042251232993 11 P46379,P09601,P50402 3 +Selective autophagy 0.5099575738022697 1.956321909502167 0.05042724481106 1.0 0.5911840854155663 28 Q8N4H5,Q8IWA4,Q9BVA1,P08670,Q9NS69,P21796 6 +Transport of inorganic cations anions and amino acids oligopeptides 0.6481075182953769 1.9378179672720828 0.0526454349166001 1.0 0.5911840854155663 11 P08195,P30825,Q9H2J7,Q96QD8,Q70HW3,Q9Y6M7,Q9UBX3 7 +Role of phospholipids in phagocytosis 0.8087607966007333 1.9376640823309212 0.0526642186959773 1.0 0.5911840854155663 5 O43865,Q8IV08 2 +Intraflagellar transport 0.6453850615090193 1.9230953722647823 0.0544680734315563 1.0 0.5911840854155663 11 Q7Z4L5,A0AVF1,Q9BVA1,Q92973,P68371 5 +Ksrp khsrp binds and destabilizes mrna 0.6442417284106831 1.9169058106114567 0.0552498987580203 1.0 0.5911840854155663 11 Q9NQT5,Q92945,Q5RKV6 3 +Transport of bile salts and organic acids metal ions and amine compounds 0.766242246163909 1.9122488803816533 0.055844279213157 1.0 0.5911840854155663 6 Q8TAD4,Q15043,Q9H2J7,Q8NEW0,P53985 5 +Synaptic adhesion like molecules 0.7009236955818463 1.8727234361437064 0.061106585350422 1.0 0.6146082642491721 8 P10586,P41440,Q92796,Q12959,O95197 5 +Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.6340502170024336 1.861561665805438 0.0626649009239166 1.0 0.6257473559884625 11 Q9NQT5,Q13868,Q5RKV6 3 +Keratan sulfate keratin metabolism 0.7859007832898393 1.8413854811399009 0.0655650889262413 1.0 0.6454208753873971 5 O43505,P06865,P15586,P16278 4 +Postmitotic nuclear pore complex npc reformation 0.5015384536297594 1.8026275733833987 0.0714467236370153 1.0 0.6629700670594623 23 Q8N1F7,P57740,Q8NFH4,P55735,Q92973,Q8NFH5,Q7Z3B4,Q9BTX1 8 +Metabolism of fat soluble vitamins 0.7744754402952 1.7929429438970437 0.0729820477260381 1.0 0.6629700670594623 5 Q8N0U8,Q07954 2 +Ros and rns production in phagocytes 0.6643658756868573 1.7786915810295174 0.0752903402112581 1.0 0.6629700670594623 9 Q93050 1 +Atf4 activates genes in response to endoplasmic reticulum stress 0.615625598653007 1.7607427763484949 0.0782819491181532 1.0 0.6629700670594623 11 Q9NQT5,Q92945,Q5RKV6 3 +Cytoprotection by hmox1 0.3819219448679533 1.7528809621789183 0.0796224420939306 1.0 0.6629700670594623 65 P28070,P09601,Q99436,P30519,Q06323,P28072,P00403,Q9UL46,P28074,P49721 10 +G alpha i signalling events 0.494813596648337 1.752156818746637 0.079746846418802 1.0 0.6629700670594623 23 P07602,O43865,P13861,P52292,Q9UBI6 5 +Aurka activation by tpx2 0.4821248113566528 1.7493566066167494 0.0802293967566774 1.0 0.6629700670594623 30 Q9H6D7,Q7Z4H7,O43805,P41208,O95684,P68371,O94927,O75935,P07437 9 +Gastrin creb signalling pathway via pkc and mapk 0.7286867741016652 1.7457539220650469 0.0808537208491657 1.0 0.6629700670594623 6 Q15418 1 +Negative regulation of nmda receptor mediated neuronal transmission 0.6717348235220059 1.7313126046297225 0.0833960245337459 1.0 0.6629700670594623 8 Q14168,Q12959,Q92796,P07196 4 +Mucopolysaccharidoses 0.8217862231851443 1.716796712438428 0.0860163218565641 1.0 0.6629700670594623 4 P54802 1 +G alpha s signalling events 0.7219258727537374 1.7155087970687393 0.08625198391917 1.0 0.6629700670594623 6 O60658 1 +Sphingolipid de novo biosynthesis 0.6073500554718569 1.7151485820343748 0.0863179891221574 1.0 0.6629700670594623 11 Q96G23,P27544,O15121 3 +Amino acid transport across the plasma membrane 0.7562010443864358 1.7150348403678335 0.0863388394287634 1.0 0.6629700670594623 5 Q96QD8,P30825,P08195,Q9H2J7 4 +Recruitment of numa to mitotic centrosomes 0.4714153102775849 1.7083725143664998 0.0875672439007881 1.0 0.6629700670594623 35 Q9H6D7,Q13561,Q7Z4H7,Q9BVA1,O43805,P41208,O95684,P68371,O94927,O75935,P07437 11 +Cell surface interactions at the vascular wall 0.5283319757717369 1.7078665053494824 0.0876611154196929 1.0 0.6629700670594623 18 Q9UNN8,P08195,P14174,O00459,P53985,Q08722,Q92896 7 +Ras activation upon ca2 influx through nmda receptor 0.7200003835961578 1.7068805724905989 0.0878442524701346 1.0 0.6629700670594623 6 Q14168,Q92796,P07196 3 +Long term potentiation 0.7200003835961578 1.7068805724905989 0.0878442524701346 1.0 0.6629700670594623 6 Q14168,Q92796,P07196 3 +Unblocking of nmda receptors glutamate binding and activation 0.7200003835961578 1.7068805724905989 0.0878442524701346 1.0 0.6629700670594623 6 Q14168,Q92796,P07196 3 +Transferrin endocytosis and recycling 0.6050093104337796 1.7022183545614835 0.0887144432724886 1.0 0.6629700670594623 11 Q93050,Q9Y5K8,P02786,Q9Y487 4 +Carboxyterminal post translational modifications of tubulin 0.7526337436437123 1.6997677269595337 0.0891746242739728 1.0 0.6629700670594623 5 Q9BVA1,P68371 2 +Epha mediated growth cone collapse 0.6467442002837553 1.6898393109571277 0.091058700815602 1.0 0.6630160699885417 9 P35579,P60660,O75116,P35580,Q13464,Q8N5V2 6 +Insulin receptor recycling 0.6249093354998014 1.687939901877715 0.0914227660184938 1.0 0.6630160699885417 10 Q93050 1 +Endosomal vacuolar pathway 0.8142086954121409 1.6861863863084567 0.0917599051864179 1.0 0.6630160699885417 4 Q9UIQ6,P10321 2 +Transport of small molecules 0.4482876877343074 1.6782687842949051 0.0932946390489883 1.0 0.6630160699885417 162 Q8TAD4,Q93050,Q15043,O15439,Q8WTV0,Q8IYU8,P49720,P30519,Q06323,P02786,Q8TDW0,P45880,P21796,Q10713,Q9BPX6,P51790,P40855,Q9Y277,Q8TB61,P35611,Q15904,Q9Y487,P09601,Q96QD8,P28072,P08183,P53985,Q70HW3,P28070,Q9Y5K8,O00231,P30825,O75027,Q9H2J7,P36404,P56589,P16615,Q9UBI6,Q9HD20,Q9H4A3,Q9C0H2,P35670,Q8WWC4,Q99436,P49721,Q9UL46,P28074,O15118,Q9H4I9,Q9Y6M7,Q9UBX3 51 +Transmission across chemical synapses 0.4528312702037753 1.6752671123138625 0.0938818350638683 1.0 0.6630160699885417 43 Q13885,Q9BVA1,P21964,O14936,Q92796,P07196,P52292,P51812,Q96QD8,Q9UBI6,Q15418,Q12959,Q14168,P68371,Q14012 15 +Apoptotic cleavage of cellular proteins 0.5143114149212475 1.6604465033831053 0.0968246615093026 1.0 0.6690069601847681 19 P20700,P02545,P49354,P35611,Q13813,P08670,Q14126,Q16625,Q13464,Q15149 10 +Unfolded protein response upr 0.4610967814461923 1.660167847381631 0.0968806909201285 1.0 0.6690069601847681 38 Q92945,Q13868,P02545,P35611,Q5RKV6,Q13217,P43307,Q9NQT5,O14773,Q9NWM8 10 +Neuronal system 0.4145982490114965 1.6464266347721312 0.09967595319081 1.0 0.6815281922603167 55 Q13885,P41440,Q9BVA1,P21964,O14936,Q92796,P07196,P52292,P51812,Q96QD8,Q9UBI6,Q15418,Q12959,O95197,Q14168,P68371,Q14012 17 +Butyrate response factor 1 brf1 binds and destabilizes mrna 0.6148761653189545 1.6347799058649497 0.1020951945975403 1.0 0.6917236310565075 10 Q9NQT5,Q5RKV6 2 +Creb phosphorylation 0.973915878708837 1.6032313043097166 0.1088835965673296 1.0 0.7306463453857571 2 Q15418 1 +Ras processing 0.6946243860074347 1.5925966493097663 0.1112507057026954 1.0 0.735314188168292 6 O43924,O60725,P49354 3 +Anchoring of the basal body to the plasma membrane 0.4608560547589546 1.583268415952746 0.1133602985086554 1.0 0.7361031230181014 31 Q9H6D7,Q7Z4H7,O43805,P41208,O95684,P68371,O94927,O75935,P07437 9 +Rsk activation 0.78669104979886 1.5745009524016556 0.1153716815215357 1.0 0.7364852946825287 4 Q15418 1 +Keratan sulfate degradation 0.785644371941258 1.5702378611189869 0.1163597843956643 1.0 0.7364852946825287 4 P06865,P15586,P16278 3 +Sialic acid metabolism 0.7223480351422191 1.5694366188469886 0.1165462370923362 1.0 0.7364852946825287 5 P16278 1 +O linked glycosylation 0.6872627743576112 1.5592545663939432 0.1189361404743643 1.0 0.7364852946825287 6 Q8NAT1,Q86SF2,O43505 3 +Mrna decay by 3 to 5 exoribonuclease 0.5275547096432647 1.5479266728747536 0.121639951952267 1.0 0.7364852946825287 14 Q969T7,Q9NQT5,Q5RKV6 3 +Recruitment of mitotic centrosome proteins and complexes 0.4547562682362598 1.5400779605599688 0.123541351282288 1.0 0.7364852946825287 32 Q9H6D7,Q7Z4H7,O43805,P41208,O95684,P68371,O94927,O75935,P07437 9 +Processing of smdt1 0.5601572628898299 1.539789709445177 0.1236116211140194 1.0 0.7364852946825287 12 Q8WWC4,Q9H4I9,Q9BPX6 3 +Perk regulates gene expression 0.5256497322299474 1.5359234269065154 0.1245571617121403 1.0 0.7364852946825287 14 Q9NQT5,Q92945,Q5RKV6 3 +Regulation of glucokinase by glucokinase regulatory protein 0.4525553382286376 1.4973657795385007 0.1342981074315421 1.0 0.7603810887763057 27 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Sumoylation of sumoylation proteins 0.4525553382286376 1.4973657795385007 0.1342981074315421 1.0 0.7603810887763057 27 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Non integrin membrane ecm interactions 0.6344358318261606 1.4759203320764112 0.1399652805836211 1.0 0.7689731128801437 7 Q9Y296,P07942,O14936,P12814 4 +Ire1alpha activates chaperones 0.4662346780234178 1.4752297752032189 0.1401507789612317 1.0 0.7689731128801437 22 P02545,Q13217,P35611,P43307,O14773,Q9NWM8 6 +Mapk targets nuclear events mediated by map kinases 0.6047140071428059 1.475173706979495 0.1401658483852135 1.0 0.7689731128801437 9 Q15418 1 +Erk mapk targets 0.6047140071428059 1.475173706979495 0.1401658483852135 1.0 0.7689731128801437 9 Q15418 1 +Signal amplification 0.6327937861081461 1.468005580821527 0.1421027069777261 1.0 0.7752251950409581 7 Q14344,Q13685,Q9UBI6 3 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.6014097665207057 1.4581515880571212 0.1447987644751678 1.0 0.7752251950409581 9 Q9HA64,P49366,O60725,Q9BU89 4 +G alpha 12 13 signalling events 0.630104570048467 1.4550348270123836 0.1456596201196998 1.0 0.7752251950409581 7 Q14344,Q9UBI6,Q13464,Q8N5V2 4 +Regulation of plk1 activity at g2 m transition 0.4407763259565325 1.4482861949524126 0.1475370269060265 1.0 0.7752251950409581 35 Q9H6D7,Q7Z4H7,O43805,P41208,Q96CV9,O95684,P68371,O94927,O75935,P07437 10 +Gap junction assembly 0.7557029508568951 1.447899661275989 0.1476451144062058 1.0 0.7752251950409581 4 Q9BVA1,P68371 2 +Transport of connexons to the plasma membrane 0.7557029508568951 1.447899661275989 0.1476451144062058 1.0 0.7752251950409581 4 Q9BVA1,P68371 2 +Nephrin family interactions 0.6115415209398866 1.4341179475956018 0.1515386070133715 1.0 0.7836748153001899 8 O14936,O00459,Q13813,O43707,P12814 5 +Cristae formation 0.4814542965205868 1.431993833126076 0.1521455862156073 1.0 0.7836748153001899 19 Q9NX63,P25705,O75964,Q16891,O75431,P00846,Q13505 7 +Sema4d induced cell migration and growth cone collapse 0.658226216710823 1.4270233557038057 0.1535731626524867 1.0 0.7836748153001899 6 P35579,P60660,P35580,Q13464 4 +Nuclear pore complex npc disassembly 0.4405013376940901 1.4100279585800113 0.1585314275436495 1.0 0.7852462474470805 30 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,P06493,Q8NFH5,Q7Z3B4,Q9BTX1 10 +Sumoylation of rna binding proteins 0.4379123307509959 1.4066253813577263 0.1595385027233982 1.0 0.7852462474470805 33 Q8IXK0,P12270,Q8N1F7,P61978,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 11 +Diseases of dna repair 0.5902203769532293 1.400372669619088 0.1614017498222559 1.0 0.7860548377308466 9 Q9UQ84,P78549 2 +Hs gag degradation 0.9233438435936594 1.391531594251684 0.1640642858883096 1.0 0.7934537589302224 3 P54802 1 +Muscle contraction 0.4380171172801457 1.380366945088616 0.1674736922982105 1.0 0.7982882021759747 27 O43865,P06753,P08133,P28289,Q9NYL9,P67936,P08670,P16615,P60660 9 +Metabolism of steroid hormones 0.6477024621024547 1.3788545850516831 0.1679395929649745 1.0 0.7982882021759747 6 O95772 1 +Ion transport by p type atpases 0.5845056454732691 1.3707884102293826 0.17044092487864 1.0 0.8046666793590217 9 P35670,Q9HD20 2 +Diseases of carbohydrate metabolism 0.5973139613121708 1.362969024854353 0.1728922729348836 1.0 0.8079948647596581 8 P10253,P54802,P16278,P13807 4 +Mitotic g2 g2 m phases 0.3650237598056848 1.3522115408251394 0.1763076528146785 1.0 0.8135343465206758 88 Q9H6D7,Q13885,Q7Z4H7,Q06323,Q96CV9,P07437,Q9BVA1,P41208,P28072,O95684,P68371,O75935,O94927,P28070,O00231,O43805,Q99436,P49721,Q9UL46,P28074,Q13561 21 +Activation of ampk downstream of nmdars 0.671344647519604 1.3475777783024911 0.1777942217921158 1.0 0.8135343465206758 5 P54619,Q9BVA1,P68371,Q13885 4 +Visual phototransduction 0.5790596743394465 1.3425527537398194 0.1794168376204112 1.0 0.8135343465206758 9 Q07954,Q6NUM9,P49354 3 +Rhoa gtpase cycle 0.4145841877855395 1.3420645670677684 0.1795750613818565 1.0 0.8135343465206758 44 P30519,P02786,Q96HY6,Q15904,O00459,Q9H2G2,Q5T8D3,Q07960,Q13464,Q07021,P41440,P49257,O15173,Q8TAA9,Q86UP2,Q14739,P51572,Q9H0H5,O75116,Q8N5V2 20 +Signaling by erbb4 0.6372837087822419 1.3310644234527356 0.1831678138603676 1.0 0.8172367105565804 6 P16949,P62993,Q15334,P61201,Q96J02 5 +Nuclear events kinase and transcription factor activation 0.5387906474270115 1.3310352573017932 0.1831774100934207 1.0 0.8172367105565804 11 P51812,Q15418 2 +Activation of kainate receptors upon glutamate binding 0.6671972745904613 1.329443714626045 0.1837016236985973 1.0 0.8172367105565804 5 Q9UBI6,Q92796 2 +Egfr downregulation 0.603341994824402 1.3254345994176402 0.1850270476487332 1.0 0.8205033295093985 7 O14964,P42566,Q92783,P62993,P60953 5 +Caspase mediated cleavage of cytoskeletal proteins 0.6651269178959582 1.3203877483865785 0.1867055919777409 1.0 0.8218225011885122 5 Q13813,P08670 2 +Neurotransmitter receptors and postsynaptic signal transmission 0.4229463687574548 1.3043575044897902 0.1921117171792203 1.0 0.8265497923219156 36 Q13885,Q9BVA1,Q92796,O14936,P07196,P52292,P51812,Q9UBI6,Q12959,Q15418,Q14168,P68371,Q14012 13 +Thromboxane signalling through tp receptor 0.6609768707988551 1.3022287324264452 0.1928382058577669 1.0 0.8265497923219156 5 Q14344,Q13685,Q9UBI6 3 +Peroxisomal protein import 0.4494149530831802 1.2967201062192717 0.1947275087098461 1.0 0.8265497923219156 21 O75381,Q13011,O15254,P39210 4 +Class i peroxisomal membrane protein import 0.5295218009714123 1.2784227071780254 0.2011004218123018 1.0 0.8408834885209849 11 Q9NR77,O75381,P56589 3 +Cytosolic iron sulfur cluster assembly 0.6239005405220354 1.2695587798160888 0.2042418402039847 1.0 0.8408834885209849 6 Q9Y5Y2 1 +Rhobtb1 gtpase cycle 0.451571323549971 1.264912351625055 0.2059027491267286 1.0 0.8408834885209849 20 P62995,Q8N684,P07910,Q5VTR2,P78371,Q16643,P08670,P38159,P61201,Q9BT78,Q13464 11 +Export of viral ribonucleoproteins from nucleus 0.4231396299832958 1.263476968372273 0.2064178186031144 1.0 0.8408834885209849 29 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Interleukin 4 and interleukin 13 signaling 0.4972682147011027 1.257173290385526 0.2086908927752984 1.0 0.8408834885209849 13 P09601 1 +Slc transporter disorders 0.4192212421502709 1.2552900617593383 0.209373481595454 1.0 0.8408834885209849 34 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q12769,Q8NFH5,Q7Z3B4,P53985,Q9BTX1 11 +Syndecan interactions 0.6492705794034909 1.2509713528960271 0.210944929284004 1.0 0.8408834885209849 5 Q9Y296,O14936,P12814 3 +Ns1 mediated effects on host pathways 0.4180366757943719 1.2451615252536536 0.2130723821322602 1.0 0.8408834885209849 34 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,P52292,Q8NFH5,Q7Z3B4,Q9BTX1 10 +Signaling by insulin receptor 0.4698915406856063 1.238115367029598 0.2156732866811748 1.0 0.8408834885209849 16 Q93050 1 +Cargo trafficking to the periciliary membrane 0.4474097374582746 1.2348945967552014 0.2168697346454307 1.0 0.8431798086494615 20 P78371,Q9UPT5,O60645,O43924,A6NIH7,Q10713 6 +Sumoylation of ubiquitinylation proteins 0.4186216199336953 1.224384309448996 0.2208072855517757 1.0 0.8537061625233002 28 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Abc family proteins mediated transport 0.3763598204348615 1.2090293004185044 0.2266515888047096 1.0 0.8609735318188226 54 P28070,O00231,O75027,O15439,Q99436,P28072,Q06323,P08183,Q9UL46,P28074,P49721 11 +Pregnenolone biosynthesis 0.6974058406437262 1.2084231754697077 0.2268845298148654 1.0 0.8609735318188226 4 O95772 1 +Sensory perception 0.4162152430296336 1.2038257109907535 0.2286569499361812 1.0 0.8609735318188226 27 Q12792,P49354,Q07954,O14936,Q13813,P53582,Q6NUM9,Q01082 8 +Heme biosynthesis 0.6087022019442906 1.1996053902687744 0.2302926321447418 1.0 0.8609735318188226 6 P36551,P22830 2 +Formation of fibrin clot clotting cascade 0.870245304864594 1.1965253527245494 0.2314916110578773 1.0 0.8609735318188226 3 P42785 1 +Sumoylation of dna replication proteins 0.4114569992986437 1.196136737728748 0.2316432032230084 1.0 0.8609735318188226 35 P12270,Q8N1F7,Q96GD4,Q9NQS7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 11 +Unwinding of dna 0.5507825907959294 1.1954197923364551 0.2319230565134997 1.0 0.8609735318188226 9 Q14566,P33991 2 +O linked glycosylation of mucins 0.687009770171536 1.1657089901775837 0.2437321240929768 1.0 0.887193495281714 4 Q86SF2,O43505 2 +Rhob gtpase cycle 0.4248114779604779 1.163050149285619 0.2448091561188015 1.0 0.887193495281714 22 P41440,O00459,Q9H2G2,P02786,Q9H0H5,Q13464 6 +Antigen processing cross presentation 0.3800054164288217 1.1614598056949228 0.2454549599137268 1.0 0.8872174071881582 51 P28070,Q03519,Q99436,P10321,P28072,Q06323,Q9UL46,P28074,P49721,Q9UIQ6 10 +Miro gtpase cycle 0.6799578445122312 1.136761644890461 0.2556379413646663 1.0 0.9098088784978382 4 Q8IWA4 1 +Purine salvage 0.6222434007060716 1.1325806832323466 0.2573903843626635 1.0 0.9137029501160536 5 P00813 1 +Recycling pathway of l1 0.4195403548187425 1.1231468394749342 0.2613751358459326 1.0 0.9204971806589614 22 P51812,Q9BVA1,Q15418,P68371 4 +Rhod gtpase cycle 0.4003866402788949 1.0761345980961914 0.2818670642775167 1.0 0.9315035362314124 26 P20700,Q14739,O00459,Q16643,Q8TAA9,O15173,P50402,Q9UEY8,Q9H0H5,Q07960,Q9Y6M7,P12814 12 +Nuclear import of rev protein 0.3991866164009893 1.0704707925507533 0.2844074490041304 1.0 0.9347991551717288 31 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Glycerophospholipid biosynthesis 0.3991940297866064 1.066516382957123 0.2861902768394055 1.0 0.9347991551717288 26 Q9NPH0,Q8NCC3,Q8IV08 3 +Plasma lipoprotein clearance 0.4761096835206652 1.045493214482109 0.295795075080806 1.0 0.9347991551717288 12 Q8WTV0 1 +Interleukin 17 signaling 0.4466678666649119 1.0323894564883718 0.3018897091600445 1.0 0.9382999257274957 14 Q15418 1 +Antigen activates b cell receptor bcr leading to generation of second messengers 0.6537426834605247 1.02948520561659 0.3032517283003879 1.0 0.9382999257274957 4 O43865,Q13586 2 +Orc1 removal from chromatin 0.366247354909558 1.0214964208226438 0.3070193039769313 1.0 0.9382999257274957 51 P28070,P33991,Q14566,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 9 +Anti inflammatory response favouring leishmania parasite infection 0.4583359105563012 1.0180353201275054 0.3086611711435538 1.0 0.9382999257274957 13 P13861,Q9UBI6,O43865 3 +Biological oxidations 0.3812177615666349 1.0137129120939332 0.3107197610243255 1.0 0.9382999257274957 43 O43169,P21964,P07099,Q16850 4 +Small interfering rna sirna biogenesis 0.8186455174972862 1.008862696011859 0.3130404878307706 1.0 0.9382999257274957 3 Q15631 1 +Cohesin loading onto chromatin 0.5264403888734803 1.0062153697213725 0.3143119803012271 1.0 0.9382999257274957 8 Q9NTI5,Q29RF7,Q9UQE7,Q9Y6X3,Q8WVM7 5 +Formation of atp by chemiosmotic coupling 0.4975764220088732 1.0007817491908857 0.3169323349026811 1.0 0.9382999257274957 10 O75964,P00846 2 +Mitotic prometaphase 0.3391721985570522 0.9962940108005824 0.3191073129506467 1.0 0.9382999257274957 91 Q9H6D7,Q13885,Q7Z4H7,Q6P1K2,P55735,P07437,Q9BVA1,P41208,O95684,O94927,P68371,O75935,Q29RF7,P57740,Q8NFH4,O14777,O43805,Q96GD4,Q15003,Q9NQS7,P06493,Q8WVM7,Q8NBT2,Q13561 24 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.4285112854221381 0.9915144953772116 0.3214344178653701 1.0 0.9382999257274957 17 O15212,Q9BVA1,P78371,P68371,Q9UHV9 5 +Transport of the slbp dependant mature mrna 0.3892423406258523 0.9874061716687051 0.3234435600261731 1.0 0.9382999257274957 31 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Nucleotide salvage 0.5200209451565635 0.9739379478056543 0.3300873503771799 1.0 0.9382999257274957 8 P00813 1 +Glycogen storage diseases 0.8131724812520329 0.9719424766875814 0.3310791665307526 1.0 0.9382999257274957 2 P10253 1 +Metal ion slc transporters 0.807240704500966 0.9678652157431794 0.3331116883481506 1.0 0.9382999257274957 3 Q15043,Q8TAD4 2 +Zinc transporters 0.807240704500966 0.9678652157431794 0.3331116883481506 1.0 0.9382999257274957 3 Q15043,Q8TAD4 2 +Ptk6 regulates proteins involved in rna processing 0.8036529680365218 0.9550164774407788 0.339569364319245 1.0 0.9407630292916408 3 P23246,O75525 2 +Switching of origins to a post replicative state 0.3311015284406516 0.9507112646336562 0.341750968277891 1.0 0.9449210039237304 61 P28070,Q9UJX4,Q9UJX3,P33991,O00231,Q96DE5,Q14566,P49720,Q99436,Q13309,P28072,Q06323,Q9UL46,Q9UBD5,P28074,P49721 16 +Zinc efflux and compartmentalization by the slc30 family 0.8069775024454031 0.948301971136246 0.3429757477006947 1.0 0.9464221427605652 2 Q8TAD4 1 +Sensory processing of sound by outer hair cells of the cochlea 0.4457156943453144 0.9407131991071858 0.3468518531120335 1.0 0.9465781482341036 13 O14936,Q12792,Q01082,Q13813 4 +Viral messenger rna synthesis 0.3834868343534576 0.9394304849605796 0.3475097673887615 1.0 0.9465781482341036 31 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Negative regulation of met activity 0.5235047563336511 0.9366503356565092 0.3489384508100355 1.0 0.947801506309842 7 P42566,O14964,Q92783,P62993 4 +Disorders of transmembrane transporters 0.3212116937522902 0.92536869059449 0.3547741591789393 1.0 0.9541074888666156 77 P08195,Q99567,P55735,P49720,Q06323,Q7Z3B4,P12270,P28072,Q8NFH5,P53985,P61289,Q9BTX1,P28070,O00231,P57740,Q8NFH4,P35613,Q8N1F7,Q99436,Q12769,P49721,Q9UL46,P28074,P20618 24 +Ca2 pathway 0.5201062243404192 0.9201869456063188 0.3574750749778885 1.0 0.9553162618942084 7 Q9UBI6 1 +Response to elevated platelet cytosolic ca2 0.3790913843683442 0.9169769006539442 0.359154744643444 1.0 0.9553162618942084 35 P07602,Q96JJ7,Q9Y6I9,O15439,O43852,Q8NBX0 6 +Listeria monocytogenes entry into host cells 0.5082952749900668 0.9151225491382996 0.3601272984497039 1.0 0.9553162618942084 8 O60716,O14964,P42566,Q92783,P62993 5 +Platelet calcium homeostasis 0.625532576630941 0.9150484559796852 0.3601661924930082 1.0 0.9553162618942084 4 P16615,Q13586 2 +Regulation of hmox1 expression and activity 0.3638618229635553 0.9138023385676444 0.3608207174128477 1.0 0.9553162618942084 47 P28070,P09601,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Regulation of runx3 expression and activity 0.3761253260143536 0.9115055298040964 0.3620290733114939 1.0 0.9553162618942084 38 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Signaling by the b cell receptor bcr 0.3601372006819444 0.8778353850683135 0.3800330585924247 1.0 0.9842358606003913 47 P28070,O43865,O00231,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 9 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.3751022109395923 0.8758558053854164 0.3811084277999619 1.0 0.9842358606003913 25 P14174,Q13126,P52597,O14979,Q9UL46 5 +Cellular response to chemical stress 0.3153325066821127 0.8741350154074591 0.3820447305622956 1.0 0.9842358606003913 75 P28070,P09601,Q99436,P30519,Q06323,P28072,P00403,Q9UL46,P28074,P49721 10 +Chondroitin sulfate dermatan sulfate metabolism 0.7851320508640566 0.8658070270330431 0.3865959949927564 1.0 0.987175739214024 2 P06865 1 +Diseases associated with glycosaminoglycan metabolism 0.7851320508640566 0.8658070270330431 0.3865959949927564 1.0 0.987175739214024 2 P06865 1 +Cs ds degradation 0.7851320508640566 0.8658070270330431 0.3865959949927564 1.0 0.987175739214024 2 P06865 1 +The role of gtse1 in g2 m progression after g2 checkpoint 0.3550392790811491 0.8652444875055626 0.3869046124873407 1.0 0.987175739214024 49 P28070,Q9BVA1,Q99436,P28072,Q06323,Q9UL46,P28074,P49721,P68371 9 +Fgfr2 alternative splicing 0.4435350866200892 0.8538818480472871 0.3931704581151898 1.0 0.9891776186091468 12 O15514,P52597,P52272,Q01085,P31943 5 +Nuclear envelope ne reassembly 0.3586668602073313 0.8470651969044042 0.3969587825583736 1.0 0.9909690471061556 46 Q8N1F7,P20700,Q14739,Q13885,P02545,Q9BVA1,P57740,Q8NFH4,P55735,P06493,P50402,Q92973,Q8NFH5,Q7Z3B4,Q86XL3,P68371,Q9BTX1 17 +Neurexins and neuroligins 0.4681755004948083 0.8416839622075307 0.3999648776691273 1.0 0.9939520587758636 10 Q14168,Q92796,O14936,Q96HC4 4 +Hedgehog off state 0.3439030553938764 0.8410819648930306 0.4003020179075705 1.0 0.9939520587758636 53 P28070,Q7Z4L5,Q9BVA1,Q99436,P28072,Q06323,Q9UL46,P28074,P49721,P68371 10 +Stabilization of p53 0.3665206246202639 0.834930560078461 0.4037568069986141 1.0 0.9973679055286891 39 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Asymmetric localization of pcp proteins 0.366505261825067 0.8347945363061542 0.4038334026708381 1.0 0.9973679055286891 39 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Degradation of axin 0.3667507058769257 0.8290548049304332 0.4070733961153134 1.0 0.998338908014466 38 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Cross presentation of soluble exogenous antigens endosomes 0.3667507058769257 0.8290548049304332 0.4070733961153134 1.0 0.998338908014466 38 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +G1 s dna damage checkpoints 0.3638191678031532 0.8197404419672814 0.4123640898704717 1.0 0.9989701998454916 40 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Establishment of sister chromatid cohesion 0.4991659316113595 0.8192839456710501 0.4126244300381709 1.0 0.9989701998454916 7 Q9NTI5,Q8WVM7,Q29RF7,Q9UQE7 4 +Abc transporters in lipid homeostasis 0.7648665960542088 0.8179449888429311 0.4133885997519879 1.0 0.9989701998454916 3 P56589 1 +Autophagy 0.3624470731792515 0.8171573376883124 0.4138385193884422 1.0 0.9989701998454916 41 Q8N4H5,Q8IWA4,Q9BVA1,P08670,Q9NS69,P68371,P21796 7 +Ub specific processing proteases 0.30502638566527 0.8132058553435835 0.4161000428791515 1.0 0.99971211490119 69 P28070,O00231,Q99436,P28072,Q06323,Q9UL46,Q96RU2,P28074,Q96K76,P49721,P45880,P21796 12 +Mitotic telophase cytokinesis 0.4621288398161695 0.809223991388206 0.4183863173763509 1.0 0.99971211490119 10 Q9NTI5,Q29RF7,Q9UQE7,Q9Y6X3,Q8WVM7 5 +The phototransduction cascade 0.5470059110289613 0.8065810442409519 0.4199078984059032 1.0 0.99971211490119 5 P49354 1 +Negative regulation of notch4 signaling 0.3619497224436088 0.803063861989745 0.4219378238137825 1.0 1.0 40 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Interleukin 12 signaling 0.3655852271977082 0.7942533304194312 0.4270479672558174 1.0 1.0 27 P14174,Q13126,P52597,O14979,Q9UL46 5 +Uch proteinases 0.3504291718738057 0.7845031822829832 0.4327449153938647 1.0 1.0 47 P28070,Q8NB78,Q99436,P28072,Q06323,Q9UL46,P28074,P49721,P85037 9 +Vegfr2 mediated cell proliferation 0.5415334157387944 0.7833549734140273 0.4334186893840628 1.0 1.0 5 P05771,O43865 2 +Displacement of dna glycosylase by apex1 0.7540769732550451 0.7805382024361399 0.4350741503036264 1.0 1.0 3 P29372,P78549 2 +Degradation of dvl 0.3594372780531644 0.7723938311611193 0.4398812064058246 1.0 1.0 39 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Toll like receptor tlr1 tlr2 cascade 0.3956676843717055 0.7710720381197756 0.4406642334348332 1.0 1.0 17 Q15418 1 +Inlb mediated entry of listeria monocytogenes into host cell 0.5139816905176601 0.7671638906573247 0.4429840790372736 1.0 1.0 6 O14964,Q92783,P62993 3 +Signaling by notch4 0.3555830870174902 0.7655712998224533 0.4439314269248113 1.0 1.0 42 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Smooth muscle contraction 0.4387094490051129 0.7635062911907717 0.4451615118292633 1.0 1.0 11 P08133,P60660,P06753 3 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.4870426283710827 0.7614284968205384 0.4464011719436622 1.0 1.0 7 Q9Y3B8 1 +Plasma lipoprotein assembly remodeling and clearance 0.3929367939864858 0.7529670799860827 0.4514696965132005 1.0 1.0 17 Q8WTV0 1 +Downstream signaling events of b cell receptor bcr 0.3514089421204828 0.7386372025770129 0.4601273274419193 1.0 1.0 43 P28070,O00231,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Rhobtb gtpase cycle 0.3568071067776622 0.7193179798836212 0.4719450201499691 1.0 1.0 30 Q12792,P62995,Q8N684,P07910,Q5VTR2,Q9NYL9,P78371,Q16643,P08670,P38159,P61201,Q9BT78,P12814,Q13464 14 +Trna modification in the nucleus and cytosol 0.4082643467526297 0.7141100668695028 0.4751591215121462 1.0 1.0 13 Q96FX7 1 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.3043715312166578 0.7132992783866055 0.4756605839293943 1.0 1.0 63 Q9UDW1,P25705,O75964,P03915,P00846,P22695,O43676,O96000,P21912,P00403 10 +Interactions of rev with host cellular proteins 0.3540255695024344 0.7005199287129348 0.4836026639694557 1.0 1.0 34 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Post chaperonin tubulin folding pathway 0.4549386701125515 0.6994984353293192 0.4842405905089366 1.0 1.0 9 Q9BVA1,P68371,P36404 3 +Signaling by gpcr 0.347961260182082 0.696826116918523 0.4859116195471848 1.0 1.0 42 P07602,O43865,O60658,P13861,O00459,P52292,P51812,Q9UBI6,Q15418,P42892,Q13464,Q8N5V2 12 +Metabolism of polyamines 0.3493695818447062 0.6916316637017877 0.4891686717564987 1.0 1.0 40 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Transport of mature mrnas derived from intronless transcripts 0.3513480347456744 0.6894064001201579 0.4905675569722314 1.0 1.0 37 P12270,Q8N1F7,Q6UN15,Q99567,P57740,P55735,Q8NFH4,Q9UKF6,Q8NFH5,Q7Z3B4,Q9BTX1 11 +Myd88 independent tlr4 cascade 0.37893699849708 0.6848986855709088 0.4934078555087788 1.0 1.0 18 Q15418 1 +Regulation of ras by gaps 0.3477345139809221 0.6772696602090374 0.4982348770601996 1.0 1.0 40 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Nrcam interactions 0.7227658186562144 0.674304357285934 0.5001178344136834 1.0 1.0 3 Q12959,Q92796 2 +Ionotropic activity of kainate receptors 0.7227658186562144 0.674304357285934 0.5001178344136834 1.0 1.0 3 Q12959,Q92796 2 +Transcriptional regulation by runx3 0.3438992928671603 0.6704424737530041 0.5025757663701493 1.0 1.0 43 P28070,O00231,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Rho gtpases activate iqgaps 0.4347636848601521 0.6641950086801697 0.5065655076522388 1.0 1.0 10 Q9BVA1,P68371 2 +Nuclear envelope breakdown 0.343235521782868 0.6545333772588616 0.5127682307041603 1.0 1.0 42 P12270,Q8N1F7,P20700,P02545,Q99567,P57740,P55735,Q8NFH4,P06493,P50402,Q8NFH5,Q7Z3B4,Q9BTX1 13 +Transcriptional regulation by runx1 0.2927855925229525 0.6494061741489184 0.516075874299569 1.0 1.0 70 P28070,O00231,Q99436,P28072,Q06323,Q9UL46,P28074,Q03164,P49721,Q16625 10 +Scf skp2 mediated degradation of p27 p21 0.3413800965962648 0.6380084204510662 0.5234681987612251 1.0 1.0 42 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Depolymerisation of the nuclear lamina 0.415862419123166 0.6375855495691143 0.5237435047139858 1.0 1.0 11 P20700,P05771,P02545,P42167,P06493,P50402 6 +Arachidonic acid metabolism 0.4510769503334494 0.633683057601218 0.526287683957726 1.0 1.0 8 Q8N8N7,Q15165,Q9H7Z7,P09960 4 +Cytochrome p450 arranged by substrate type 0.7104527673095145 0.6336382042567881 0.5263169621780119 1.0 1.0 3 Q16850 1 +Sumoylation of chromatin organization proteins 0.3452087635847203 0.6330688073818792 0.5266887108429463 1.0 1.0 36 Q8IXK0,P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q12769,Q8NFH5,Q7Z3B4,Q9BTX1 11 +Mitochondrial biogenesis 0.345446008473085 0.6280783812049625 0.5299525945440644 1.0 1.0 30 Q9NX63,P25705,O75964,Q16891,O75431,P00846,Q13505,P48735 8 +Formation of tubulin folding intermediates by cct tric 0.4040737994116597 0.6269482933355967 0.5306931294641624 1.0 1.0 12 Q9BVA1,P68371,P78371 3 +Interleukin 12 family signaling 0.3452634162043272 0.6266246791004866 0.5309052872284545 1.0 1.0 30 P14174,Q13126,P52597,O14979,Q9UL46 5 +G2 m checkpoints 0.2995361953423945 0.6228587790576942 0.53337732806951 1.0 1.0 80 P28070,P33991,Q9Y3B8,Q14566,Q99436,Q9UQ84,P28072,P49721,Q9UL46,P28074,Q06323 11 +Hedgehog on state 0.3380404961327478 0.617737915649515 0.5367481142816073 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Linoleic acid la metabolism 0.7160091294424498 0.6172570830134052 0.5370651696176323 1.0 1.0 2 P33121 1 +Auf1 hnrnp d0 binds and destabilizes mrna 0.337840211242628 0.615945021225036 0.5379308062586121 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Protein folding 0.3431839137345955 0.6130599008776209 0.5398367330751581 1.0 1.0 35 O15212,Q9BVA1,P78371,P36404,Q9UBI6,Q9Y2T2,Q9UHV9,P68371,P04062 9 +Toll like receptor 9 tlr9 cascade 0.3641167160798693 0.6114701310132145 0.5408883865074334 1.0 1.0 19 Q15418 1 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.3233402540327971 0.6100191003364933 0.5418491550160347 1.0 1.0 52 P28070,Q96GD4,Q9UJX4,Q96DE5,O00231,Q99436,Q13309,P28072,Q06323,Q9UL46,P28074,P49721 12 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.3358143530512446 0.6080450480006115 0.5431575968176108 1.0 1.0 44 P28070,O00231,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Signaling by ptk6 0.4005227364115145 0.6070174801179965 0.5438393117012055 1.0 1.0 12 Q14185,Q8IZL8,P46108,P23246,Q07666,O75525 6 +Diseases associated with glycosylation precursor biosynthesis 0.4450955781017352 0.6051372439871392 0.5450878094657696 1.0 1.0 8 P16278 1 +Synthesis of substrates in n glycan biosythesis 0.3775429016186923 0.5985983372323495 0.5494407651460254 1.0 1.0 14 P16278 1 +Diseases of glycosylation 0.3678812443878084 0.58958662368856 0.5554678216896047 1.0 1.0 17 P06865,P16278 2 +Synthesis of pips at the er membrane 0.7039452233452872 0.5764943778327273 0.5642810689143418 1.0 1.0 2 Q13614 1 +Regulation of pten stability and activity 0.3339499611689617 0.5723511817677033 0.5670840818567555 1.0 1.0 42 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Cellular response to hypoxia 0.3355748856408845 0.5716016241936042 0.5675918948519398 1.0 1.0 40 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Dag and ip3 signaling 0.4287058060028944 0.5690912396961895 0.5692942230997429 1.0 1.0 9 O43865,P52292 2 +Sulfur amino acid metabolism 0.4159218566922407 0.5668671588845378 0.5708044381139865 1.0 1.0 10 P32929,Q13126,Q9UBX3 3 +Intrinsic pathway for apoptosis 0.3631260640952415 0.5592839814031925 0.575967925838464 1.0 1.0 17 Q9NR28 1 +Regulation of pten localization 0.698728399087055 0.5591659505191264 0.5760484686356546 1.0 1.0 2 Q93009 1 +Neurotransmitter release cycle 0.4650947023024664 0.5544588734281041 0.5792648441842645 1.0 1.0 6 O14936 1 +Interferon gamma signaling 0.3807389240138432 0.5530063861801704 0.5802590372143346 1.0 1.0 13 P29372,O15344,P10321,P04439 4 +Apoptosis 0.3006303245280491 0.541845308215765 0.5879250760076373 1.0 1.0 89 P28070,P02545,P49354,Q9Y3B8,O00231,Q9NR28,P08670,Q99436,P28072,P49721,Q9UL46,P28074,Q06323,Q16625 14 +Sema4d in semaphorin signaling 0.4314699595122792 0.5410297092129123 0.588487105404409 1.0 1.0 8 P60660,P35580,Q13464 3 +Cdt1 association with the cdc6 orc origin complex 0.3308528493186818 0.5377363203449823 0.5907591006182433 1.0 1.0 41 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Reactions specific to the complex n glycan synthesis pathway 0.6918813172481192 0.5367119474414701 0.591466602036506 1.0 1.0 2 P04066 1 +N glycan antennae elongation in the medial trans golgi 0.6918813172481192 0.5367119474414701 0.591466602036506 1.0 1.0 2 P04066 1 +Degradation of cysteine and homocysteine 0.480039972925995 0.5318218459380801 0.5948493907671315 1.0 1.0 5 P32929,Q9UBX3 2 +Degradation of gli1 by the proteasome 0.3281165837249377 0.5297148443975793 0.5963096542137463 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Cyclin a cdk2 associated events at s phase entry 0.3277600379773916 0.5265860962061877 0.5984810493465569 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.418811304833944 0.5211658226989249 0.6022512605631141 1.0 1.0 9 Q9Y3B8 1 +G alpha z signalling events 0.433664291416742 0.5151624202233369 0.6064395269921419 1.0 1.0 7 Q9UBI6,P05771 2 +Peroxisomal lipid metabolism 0.3838551235514322 0.5150191538783151 0.6065396355161612 1.0 1.0 12 O14734,O14975,Q9BY49,P51648,O15254,Q15067 6 +Apc c mediated degradation of cell cycle proteins 0.2955982757162735 0.5135128711509567 0.6075926096385644 1.0 1.0 60 P28070,Q96GD4,Q9UJX4,Q9UJX3,Q96DE5,O00231,P06493,P49720,Q99436,Q13309,P28072,Q06323,Q9UL46,P28074,P49721 15 +Interferon signaling 0.283967739238072 0.5098239554550424 0.6101748012799333 1.0 1.0 64 P12270,Q8N1F7,P29372,O15344,Q99567,P57740,P55735,Q8NFH4,P52292,P19474,P10321,Q8NFH5,P04439,Q9Y4X5,Q7Z3B4,Q12769,Q9BTX1 17 +Metabolism of folate and pterines 0.4315576754626191 0.5058387796251774 0.612969832402257 1.0 1.0 7 P41440 1 +Fceri mediated nf kb activation 0.3250980105714128 0.5033087362648468 0.6147472251659134 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Signaling by hedgehog 0.2994503600947488 0.5006331389221375 0.6166293355166022 1.0 1.0 58 P28070,Q7Z4L5,Q9BVA1,Q99436,P28072,Q06323,Q9UL46,P28074,P49721,P68371 10 +Interleukin receptor shc signaling 0.6798174111509722 0.4979944555619224 0.6184879500972564 1.0 1.0 2 O00459 1 +Clec7a dectin 1 signaling 0.317732180741081 0.4910755638597157 0.623373003907278 1.0 1.0 48 P28070,O43865,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Signalling to ras 0.6603130506691959 0.4763606442115701 0.6338174676786728 1.0 1.0 3 P11234 1 +Egfr transactivation by gastrin 0.6726442777958901 0.4755133709580079 0.6344211051849884 1.0 1.0 2 P62993 1 +Acetylcholine regulates insulin secretion 0.6726442777958892 0.4755133709580054 0.6344211051849902 1.0 1.0 2 P29992 1 +Runx3 regulates p14 arf 0.6703619171829295 0.468448589207685 0.6394638277726863 1.0 1.0 2 P25440 1 +Runx1 regulates transcription of genes involved in differentiation of myeloid cells 0.6703619171829126 0.4684485892076329 0.6394638277727236 1.0 1.0 2 P05771 1 +Signaling by notch 0.307014071495854 0.4682050797679793 0.6396379398722265 1.0 1.0 53 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721,P67809 8 +Dna replication pre initiation 0.2823416107071551 0.4574762035098186 0.6473288026425337 1.0 1.0 63 P28070,P33991,Q14566,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 9 +Myogenesis 0.4605091383811941 0.4570925176039181 0.647604548163194 1.0 1.0 5 P35222,P35221,O60271,P60953 4 +Signaling by vegf 0.3210453816105888 0.4494417324783925 0.6531130321100242 1.0 1.0 27 O43865,P05771,Q96F07,Q14185,P46108,O00459,Q9UQB8,Q13685,Q13464 9 +Opioid signalling 0.3384801105234152 0.4436041714834294 0.657328789266016 1.0 1.0 19 Q9UBI6,O43865,P52292 3 +Kinesins 0.3410324159801904 0.4397705443610969 0.6601033034908368 1.0 1.0 18 Q13885,Q9BVA1,Q86Y91,Q9NSK0,Q9H0H5,P68371 6 +Signaling by interleukins 0.3075354263510984 0.4380308178090121 0.6613639435664709 1.0 1.0 108 P28070,P14174,Q13126,P52597,O00231,P09601,P08670,O14979,P51812,Q99436,P28072,Q15418,P49721,Q9UL46,P28074,Q06323 16 +Dectin 1 mediated noncanonical nf kb signaling 0.3172524578716186 0.4356281557427466 0.663106539242349 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Tnfr2 non canonical nf kb pathway 0.3172524578716186 0.4356281557427466 0.663106539242349 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Hcmv early events 0.3172169475572357 0.4353252187433664 0.6633263822154214 1.0 1.0 43 P12270,Q8N1F7,Q13885,Q9BVA1,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,P68371,Q9BTX1 12 +Mapk family signaling cascades 0.2947982159851542 0.4324922125831298 0.665383710896327 1.0 1.0 93 P49720,Q06323,O43924,P49354,Q92796,O00459,P28072,Q14168,P28070,O60725,O00231,Q99956,Q13813,P36404,Q01082,P07196,P06493,Q99436,Q12959,P49721,Q9UL46,Q96P70,P28074 23 +Hedgehog ligand biogenesis 0.3178010066459069 0.4271269948417015 0.6692868318693828 1.0 1.0 41 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Miscellaneous transport and binding events 0.4332822957023658 0.4247750343717598 0.6710006788639791 1.0 1.0 6 P35611,Q8TDW0 2 +Stimuli sensing channels 0.3753001885028431 0.4244325020093241 0.6712504214185282 1.0 1.0 11 P51790,Q9C0H2 2 +Dap12 interactions 0.4331917194227374 0.4244190254637325 0.6712602479973953 1.0 1.0 6 P10321 1 +Fcgr3a mediated il10 synthesis 0.4127092855765683 0.424242537034201 0.6713889417613741 1.0 1.0 7 O43865 1 +Collagen biosynthesis and modifying enzymes 0.3750958184559714 0.4234051924977678 0.6719996570701756 1.0 1.0 11 O15460,Q32P28,P13674 3 +Nuclear signaling by erbb4 0.6366601435094491 0.4078351251382276 0.683394724099134 1.0 1.0 3 P16949,P61201 2 +Phospholipid metabolism 0.3159660403215342 0.4027919906603054 0.687101253734568 1.0 1.0 39 P67870,Q8IV08,O00459,Q8NCC3,Q96N66,Q9NPH0,Q9BTU6,Q9UG56,Q8TBX8,Q13614,Q8NF37,Q10713 12 +Clathrin mediated endocytosis 0.3017689560229536 0.4007878709941617 0.688576309546753 1.0 1.0 52 P50570,P20645,O14976,Q14C86,Q14108,P11717,Q99627,O00291 8 +L1cam interactions 0.3138864649865176 0.4004357579422545 0.6888355914824058 1.0 1.0 42 P50570,Q01082,Q13885,P67870,Q9BVA1,Q92796,P07942,Q13813,P51812,Q12959,Q15418,Q96P70,P68371 13 +Role of lat2 ntal lab on calcium mobilization 0.6332975976800439 0.3984383764902106 0.6903070742399939 1.0 1.0 3 O00459 1 +Rac2 gtpase cycle 0.3158596824378539 0.3945790551113612 0.6931535734813941 1.0 1.0 36 Q14739,Q14185,O00459,Q14126,O15173,Q8TAA9,P02786,P50402,Q13505,Q9H0H5,Q07960,Q86XL3 12 +The citric acid tca cycle and respiratory electron transport 0.2936606214750787 0.3901572553086985 0.6964202672120448 1.0 1.0 96 Q9UDW1,P25705,O75964,P03915,P00846,O43676,O96000,Q13423,Q9H9P8,P00403,P53985,P48735,P21796 13 +Degradation of beta catenin by the destruction complex 0.3056511881674375 0.3818299703527676 0.7025874869173427 1.0 1.0 48 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Tcr signaling 0.3068098660318125 0.3811451367470257 0.7030955563675954 1.0 1.0 47 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +G protein mediated events 0.3575103799699438 0.37631104329971 0.70668567031995 1.0 1.0 12 P13861,O43865,P52292 3 +Activated notch1 transmits signal to the nucleus 0.6364525595044 0.36894187607476 0.7121710491844098 1.0 1.0 2 Q96J02 1 +Initiation of nuclear envelope ne reformation 0.3329100237774221 0.3612723024258005 0.7178958969437343 1.0 1.0 16 P20700,Q14739,P02545,P50402,Q86XL3 5 +Toll like receptor cascades 0.3057610449858937 0.3509268500561585 0.725643227485615 1.0 1.0 25 Q15418 1 +Synthesis of pips at the plasma membrane 0.3806764595634249 0.3456447479942411 0.7296097122918264 1.0 1.0 9 O00459,Q9BTU6,Q8TBX8,Q13614,P20339 5 +Retrograde transport at the trans golgi network 0.3317205117995855 0.3439219829441317 0.7309049592019343 1.0 1.0 15 P20645,Q8N1B4,Q5VZE5,P51151,P11717,Q99747 6 +Inla mediated entry of listeria monocytogenes into host cells 0.6269970655363498 0.3431669782306745 0.7314728454967827 1.0 1.0 2 O60716 1 +Senescence associated secretory phenotype sasp 0.3140418978299294 0.3324875867674092 0.7395211114127227 1.0 1.0 21 Q15418 1 +Aggrephagy 0.3298833715088122 0.3256396568496528 0.7446970043691146 1.0 1.0 14 Q9BVA1,P68371,P08670 3 +Adp signalling through p2y purinoceptor 1 0.6058349119860482 0.3252361436316693 0.7450023556862937 1.0 1.0 3 Q9UBI6 1 +G protein activation 0.6058349119860482 0.3252361436316693 0.7450023556862937 1.0 1.0 3 Q9UBI6 1 +Defective cftr causes cystic fibrosis 0.3033317219410157 0.3196221760818815 0.7492547614584231 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Abc transporter disorders 0.3033317219410157 0.3196221760818815 0.7492547614584231 1.0 1.0 43 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Regulation of runx2 expression and activity 0.3003384774739387 0.3162281950358874 0.7518293084327379 1.0 1.0 46 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Platelet homeostasis 0.3630009295214831 0.3123553014947527 0.7547705163268617 1.0 1.0 10 P16615,Q9UBI6 2 +Gene silencing by rna 0.3023664229911433 0.3118043458284069 0.7551892211001983 1.0 1.0 43 P12270,Q8N1F7,Q15631,Q99567,P57740,P55735,Q8NFH4,Q9Y2W6,Q8NFH5,Q7Z3B4,Q9BTX1,O75569 12 +Reduction of cytosolic ca levels 0.5985473513284113 0.3069373908025734 0.7588910280969872 1.0 1.0 3 P16615 1 +Signaling by fgfr 0.3187738402539133 0.3068614125844592 0.7589488612227273 1.0 1.0 18 P52597 1 +Signaling by fgfr2 0.3187738402539133 0.3068614125844592 0.7589488612227273 1.0 1.0 18 P52597 1 +C type lectin receptors clrs 0.2899864394108046 0.3067704321258853 0.7590181155329385 1.0 1.0 53 P28070,O43865,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Alpha oxidation of phytanate 0.4559646266260807 0.3012346125617687 0.7632355978651875 1.0 1.0 4 P51648,Q9BY49 2 +Fc epsilon receptor fceri signaling 0.2878518014162708 0.2872791968115182 0.7738985501591567 1.0 1.0 53 P28070,O43865,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Cargo recognition for clathrin mediated endocytosis 0.299465225897554 0.286190327562319 0.7747323515560693 1.0 1.0 29 P20645,Q14108,P11717,Q99627 4 +Rhoc gtpase cycle 0.2982049814570294 0.2734603889278445 0.7844993373346334 1.0 1.0 30 Q14739,P41440,P49257,Q9H2G2,Q8TAA9,Q5T8D3,P02786,Q9H0H5,Q07960,O75116,Q13464,Q07021 12 +Diseases of mitotic cell cycle 0.3159849364964379 0.2682735580268209 0.7884887580820426 1.0 1.0 16 Q13309,Q9UJX4,Q96DE5,P46100 4 +Programmed cell death 0.284815875805284 0.262117176355138 0.7932311048021596 1.0 1.0 99 P28070,P41440,P02545,P49354,Q9Y3B8,O00231,Q9NR28,P08670,Q99436,P28072,P49721,Q9UL46,P28074,Q06323,Q16625 15 +Signaling by egfr 0.3397169128061171 0.2553942116538105 0.7984186410270158 1.0 1.0 11 O14964,P42566,Q13685,Q92783,P62993,P60953 6 +Mitotic g1 phase and g1 s transition 0.2619680652357191 0.2539520573603796 0.7995325967517832 1.0 1.0 73 P28070,P33991,Q14566,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 9 +Synthesis of bile acids and bile salts 0.369209993076683 0.2518640322045912 0.8011461616528761 1.0 1.0 7 Q9H4L5,O14734 2 +Bile acid and bile salt metabolism 0.369209993076683 0.2518640322045912 0.8011461616528761 1.0 1.0 7 Q9H4L5,O14734 2 +Regulation of kit signaling 0.5747705156707079 0.2507974177859047 0.8019707380964103 1.0 1.0 3 P62993 1 +Deubiquitination 0.2737435205774283 0.250301237467132 0.8023543995611566 1.0 1.0 87 P28070,P85037,Q8NB78,Q9Y277,Q96K76,O00231,Q99436,Q13309,P28072,P49721,Q9UL46,P28074,Q06323,Q96RU2,Q9NWV8,P45880,P21796 17 +Rac3 gtpase cycle 0.296102852787753 0.249956280175071 0.8026211589436585 1.0 1.0 33 Q14739,O00459,Q9UQB8,Q14126,O15173,Q8TAA9,P02786,Q15758,P50402,Q9H0H5,Q07960 11 +Interferon alpha beta signaling 0.357008649701264 0.2464797126007668 0.8053109070964515 1.0 1.0 9 P10321,P04439 2 +Hcmv late events 0.2954110470800342 0.2419619304144763 0.80880966195149 1.0 1.0 35 P12270,Q8N1F7,Q9BRG1,P61978,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 11 +Synthesis of very long chain fatty acyl coas 0.3613357256118898 0.2414207075068561 0.8092290650523033 1.0 1.0 8 Q9UKU0,Q9P035 2 +Notch4 activation and transmission of signal to the nucleus 0.5849364199543452 0.2402728617155415 0.8101187320639918 1.0 1.0 2 Q92542 1 +Hdr through homologous recombination hrr 0.3017651743553097 0.2400882754075683 0.8102618233000562 1.0 1.0 20 P41440 1 +Integrin cell surface interactions 0.3949767329264723 0.2354674238450559 0.8138459601002848 1.0 1.0 5 Q08722 1 +Regulation of tp53 activity through phosphorylation 0.2883197168126266 0.2345977770057981 0.814520935100387 1.0 1.0 25 Q9UQ84,Q92804 2 +Aquaporin mediated transport 0.3641519623710437 0.2336018553544838 0.8152940872331667 1.0 1.0 7 Q9UBI6 1 +Cdc42 gtpase cycle 0.2920444135264005 0.2246500253794975 0.822251544784576 1.0 1.0 32 Q14739,O00459,Q9UQB8,P02786,Q9H0H5,Q8TAA9,Q86UP2,Q8N5V2 8 +Transcriptional regulation by small rnas 0.2927067954749825 0.2221234012468436 0.824217821298074 1.0 1.0 36 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,Q9BTX1 9 +Met activates ras signaling 0.4270799347471257 0.2218832705565064 0.8244047541034423 1.0 1.0 4 Q96S59,Q96P70,P62993 3 +Signaling by flt3 fusion proteins 0.4235710967691056 0.2129917811090032 0.8313333733301704 1.0 1.0 4 Q01082,Q9UBW7 2 +Transcriptional regulation by runx2 0.2791763858728139 0.210150782340799 0.8335499917311631 1.0 1.0 53 P28070,Q96PK6,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Transcriptional regulation by e2f6 0.3515898531363259 0.2053801993026708 0.837275089201706 1.0 1.0 8 Q9UBK9,Q13185 2 +Rho gtpases activate rocks 0.3425430994084714 0.1906005809154452 0.8488385350314263 1.0 1.0 9 P60660,P35580,Q13464 3 +Glucagon signaling in metabolic regulation 0.3661798452022061 0.1890845535774582 0.8500265475696007 1.0 1.0 6 Q9UBI6 1 +Vasopressin regulates renal water homeostasis via aquaporins 0.3661798452022061 0.1890845535774582 0.8500265475696007 1.0 1.0 6 Q9UBI6 1 +Interleukin 1 signaling 0.2844196563625915 0.1875536241434618 0.8512265835472457 1.0 1.0 46 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Interaction between l1 and ankyrins 0.4094405530221183 0.1789273760905873 0.857994726640823 1.0 1.0 4 Q13813 1 +Signaling by pdgfr in disease 0.3611071123254933 0.1739981483306258 0.8618669174524936 1.0 1.0 6 O00459 1 +Processing of intronless pre mrnas 0.2977968305407777 0.1711372883675523 0.8641158164765224 1.0 1.0 15 Q5KU26,Q8N684,Q6UN15,Q9UKF6,Q86U42,P33240,Q9P2I0 7 +Sumoylation of dna damage response and repair proteins 0.2828662806695713 0.1701053657527405 0.8649272737572693 1.0 1.0 45 Q8IXK0,P12270,Q8N1F7,Q99567,P57740,P55735,P41208,Q8NFH4,Q8NFH5,Q8WVM7,Q7Z3B4,Q9BTX1 12 +Nrage signals death through jnk 0.3703119687036871 0.1671576072725628 0.8672460395327146 1.0 1.0 5 Q14344,Q8N5V2 2 +Intra golgi traffic 0.2976737807881379 0.1668667838744998 0.8674748692903471 1.0 1.0 14 O95249,O00461 2 +Association of tric cct with target proteins during biosynthesis 0.2953252022104587 0.164752710258038 0.8691386270260706 1.0 1.0 16 Q9Y2T2,P78371 2 +Dna strand elongation 0.2780556986492861 0.164389152404973 0.8694248025338585 1.0 1.0 26 Q14566,P41440,P33991 3 +Sensory processing of sound 0.2908600186060396 0.1578809541934891 0.8745506061767558 1.0 1.0 18 O14936,Q12792,Q01082,Q13813 4 +Signaling by mras complex mutants 0.540267362243228 0.153934551114191 0.8776613409250447 1.0 1.0 2 P31946 1 +Potential therapeutics for sars 0.2822581469385504 0.1496453176509489 0.8810444524090562 1.0 1.0 39 P49354,P62942,P21964,Q99720,P07437 5 +Signaling by erbb2 ecd mutants 0.3577023498694515 0.1360349077542528 0.8917936850632484 1.0 1.0 5 Q16543,Q96RT1,P19174,P62993 4 +Signaling by erbb2 in cancer 0.3577023498694515 0.1360349077542528 0.8917936850632484 1.0 1.0 5 Q16543,Q96RT1,P19174,P62993 4 +Synthesis of dna 0.2592139486300374 0.131839494504446 0.8951112470948464 1.0 1.0 83 P28070,P41440,P33991,O00231,Q96DE5,Q14566,Q99436,P28072,P49721,Q9UL46,P28074,Q06323 12 +Synthesis of gdp mannose 0.5123016432463869 0.1317087935340266 0.8952146298819839 1.0 1.0 3 Q9Y5P6 1 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.2846103057464227 0.1278702546891235 0.8982516510878025 1.0 1.0 18 P16278 1 +Pyruvate metabolism and citric acid tca cycle 0.2781942232970335 0.1262265463076246 0.8995525985107928 1.0 1.0 35 Q13423,Q9H9P8,P21796,P53985 4 +Platelet adhesion to exposed collagen 0.5223345288555518 0.1261944256812973 0.8995780237536151 1.0 1.0 2 P05556 1 +Apoptotic execution phase 0.274703791267598 0.1220612966374968 0.902850473431511 1.0 1.0 30 P20700,P02545,P49354,P35611,Q13813,P08670,Q14126,Q16625,Q13464,Q15149 10 +Insulin processing 0.3062959470689337 0.1196736246161947 0.90474169467949 1.0 1.0 11 Q8NEW0,O60645,Q9UPT5,Q8TAD4 4 +Golgi associated vesicle biogenesis 0.2749476508846284 0.1190378028764354 0.9052454063279154 1.0 1.0 31 P50570,Q99523,O14976,Q9H3P7,O75976,Q14671,P11717,P02786,Q92572,P55327 10 +Glucagon like peptide 1 glp1 regulates insulin secretion 0.3280000460283519 0.1164246084184496 0.9073160333105564 1.0 1.0 7 Q9UBI6 1 +Adenylate cyclase inhibitory pathway 0.5119008803390819 0.1118554678130065 0.9109380064756074 1.0 1.0 2 P04899 1 +Adora2b mediated anti inflammatory cytokines production 0.3195903881204808 0.1105847734817146 0.9119456224224372 1.0 1.0 9 Q9UBI6 1 +Interleukin 1 family signaling 0.2719379141128508 0.1054229429009459 0.9160402116998596 1.0 1.0 48 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Deadenylation dependent mrna decay 0.2743096765579837 0.1045430694005489 0.9167383910701576 1.0 1.0 34 Q9NQT5,P23588,Q969T7,Q5RKV6 4 +Activation of atr in response to replication stress 0.2792336063894225 0.1031578957154358 0.917837655925544 1.0 1.0 18 P33991 1 +Downregulation of erbb2 signaling 0.3423629242819881 0.101833488639885 0.9188888437232494 1.0 1.0 5 Q9UNE7,Q96RT1,Q16543,P07900 4 +Mitotic prophase 0.2527170955038342 0.100920272844222 0.9196137498662488 1.0 1.0 61 P12270,Q8N1F7,P20700,P02545,Q08379,Q99567,P57740,P55735,Q8NFH4,Q01105,P06493,P50402,Q8NFH5,Q7Z3B4,Q9BTX1 15 +Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.3678674913164035 0.0957050167656305 0.9237548563901964 1.0 1.0 4 O14734 1 +Signaling by braf and raf1 fusions 0.26339534816564 0.0950712272303407 0.9242582518783532 1.0 1.0 24 Q96PU8,Q6WCQ1,P02545,Q9NRY5 4 +Thrombin signalling through proteinase activated receptors pars 0.3313203348108587 0.0947330812757634 0.9245268410727 1.0 1.0 6 Q14344,Q9UBI6 2 +Signaling by erbb2 0.3072899640405323 0.0945406295941584 0.924679709209101 1.0 1.0 10 Q93034,P19174,Q05655,Q9UNE7,Q16543,P17252,P07900,P62993,Q96RT1 9 +Signaling by ntrk3 trkc 0.497554613628943 0.0942419583930276 0.9249169550939262 1.0 1.0 2 P62993 1 +Signaling by fgfr4 in disease 0.497554613628943 0.0942419583930276 0.9249169550939262 1.0 1.0 2 P62993 1 +Erythropoietin activates phospholipase c gamma plcg 0.4975546136289427 0.0942419583930273 0.9249169550939264 1.0 1.0 2 P07948 1 +Separation of sister chromatids 0.2743579794385103 0.0840736745196399 0.9329978552130964 1.0 1.0 107 Q13885,Q6P1K2,P55735,P49720,Q06323,Q9BVA1,P28072,P68371,P28070,Q29RF7,O00231,P57740,Q8NFH4,O14777,Q96GD4,Q9UJX4,Q9UJX3,Q96DE5,Q9NQS7,Q99436,Q12769,P49721,Q9UL46,P28074,Q8WVM7,Q8NBT2 26 +Rhobtb2 gtpase cycle 0.2714501849395325 0.0833686919210434 0.933558382053666 1.0 1.0 20 Q12792,P62995,Q9NYL9,P78371,P38159,P12814 6 +Constitutive signaling by egfrviii 0.3575856443719387 0.079135049170171 0.9369252057114366 1.0 1.0 4 Q16543,P19174,P62993 3 +Signaling by egfr in cancer 0.3575856443719387 0.079135049170171 0.9369252057114366 1.0 1.0 4 Q16543,P19174,P62993 3 +Constitutive signaling by ligand responsive egfr cancer variants 0.3575856443719387 0.079135049170171 0.9369252057114366 1.0 1.0 4 Q16543,P19174,P62993 3 +Constitutive signaling by overexpressed erbb2 0.3575856443719386 0.079135049170171 0.9369252057114366 1.0 1.0 4 Q16543,Q96RT1,P62993 3 +Mecp2 regulates neuronal receptors and channels 0.3235390140385258 0.0767781820183105 0.9388000077220104 1.0 1.0 6 Q96ST3,P51608,P18031,Q92769,Q9NWH9 5 +Plasma lipoprotein remodeling 0.476361265079881 0.0724685097904434 0.9422290651048366 1.0 1.0 2 P07237 1 +Ptk6 regulates cell cycle 0.47310074991848 0.0695451919582876 0.9445556617251564 1.0 1.0 2 P11802 1 +Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.4731007499184729 0.0695451919582815 0.9445556617251614 1.0 1.0 2 P04637 1 +Gap junction trafficking and regulation 0.2863342072321411 0.0688016821198764 0.9451474791247148 1.0 1.0 12 P50570,Q9BVA1,P68371 3 +Cell death signalling via nrage nrif and nade 0.308522343277741 0.0641101192975763 0.9488825443894008 1.0 1.0 7 Q14344,Q8N5V2 2 +Trans golgi network vesicle budding 0.2684213806560225 0.0608012996517071 0.9515174552659188 1.0 1.0 38 P50570,P20645,Q99523,O14976,Q9H3P7,O75976,Q14671,P11717,P02786,P15586,Q92572,P55327 12 +Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0.2702822754147534 0.0573783894337325 0.9542437773697512 1.0 1.0 16 Q8IXK0,Q969G3,O14497,P67870 4 +Notch hlh transcription pathway 0.4492989892402997 0.051369025637497 0.9590314661349706 1.0 1.0 2 Q92769 1 +Shc1 events in erbb2 signaling 0.4448793215916315 0.0511542215556564 0.9592026299591212 1.0 1.0 3 P17252,P62993 2 +Synthesis of ketone bodies 0.3367047308319771 0.0503054216893691 0.9598790033586966 1.0 1.0 4 P35610,P35914,Q9BUT1 3 +Ketone body metabolism 0.3367047308319771 0.0503054216893691 0.9598790033586966 1.0 1.0 4 P35610,P35914,Q9BUT1 3 +Regulation of innate immune responses to cytosolic dna 0.4430332382928022 0.049603550265421 0.960438317414194 1.0 1.0 3 P19474 1 +Respiratory electron transport 0.2593240728528108 0.0489484706079507 0.9609603611709724 1.0 1.0 53 Q9UDW1,P03915,O43674,P22695,O43676,O96000,P21912,P00403 8 +Citric acid cycle tca cycle 0.2670322045153702 0.0473919752592819 0.9622008246510336 1.0 1.0 17 Q13423,P48735 2 +Oncogenic mapk signaling 0.2591065299879025 0.0461515730229388 0.9631894404422968 1.0 1.0 28 P02545,Q96PU8,Q99956,Q6WCQ1,Q9NRY5 5 +Synthesis of pc 0.4358309953456968 0.0438558096114144 0.965019340206082 1.0 1.0 3 Q8NF37 1 +Beta catenin independent wnt signaling 0.2531790829553186 0.0435081447142305 0.9652964721325066 1.0 1.0 57 P28070,O00231,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 8 +Platelet aggregation plug formation 0.3097258485639766 0.0427652759044997 0.9658886444665438 1.0 1.0 5 P41240,P46108,P18031,P62993 4 +Integrin signaling 0.3097258485639766 0.0427652759044997 0.9658886444665438 1.0 1.0 5 P41240,P46108,P18031,P62993 4 +Met activates pi3k akt signaling 0.4268014346266706 0.0387695660849184 0.9690741093299372 1.0 1.0 2 P62993 1 +Met interacts with tns proteins 0.4268014346266563 0.0387695660849114 0.9690741093299426 1.0 1.0 2 P05556 1 +Mapk6 mapk4 signaling 0.2588423998846254 0.0371592078385371 0.9703580635617725 1.0 1.0 52 P28070,Q99436,P28072,Q06323,Q9UL46,P28074,P49721 7 +Biosynthesis of specialized proresolving mediators spms 0.4228794142917297 0.0346813736812366 0.972333813640916 1.0 1.0 3 P09960 1 +G0 and early g1 0.3203915171288742 0.0320922133417615 0.9743985130666012 1.0 1.0 4 P24941,P06493,P12004 3 +Hcmv infection 0.259707023977845 0.0297701167710548 0.9762503915609612 1.0 1.0 50 P12270,Q8N1F7,Q13885,Q9BRG1,P61978,Q9BVA1,Q99567,P57740,P55735,Q8NFH4,Q8NFH5,Q7Z3B4,P68371,Q9BTX1 14 +Mecp2 regulates transcription of neuronal ligands 0.4039778284968954 0.0297387572427665 0.9762754017708636 1.0 1.0 2 Q96ST3 1 +Leishmania infection 0.2629474267802826 0.0285539231946077 0.9772203610487225 1.0 1.0 38 P09601,Q9UBI6,O43865,Q9UQB8 4 +Rhof gtpase cycle 0.2618016487629186 0.0277041378316197 0.9778981234592504 1.0 1.0 17 P20700,O00459,Q8TAA9,Q9Y6M7,P12814 5 +Wax and plasmalogen biosynthesis 0.3151712887438829 0.0270183762731729 0.9784450772347948 1.0 1.0 4 O00116,Q8WVX9,O15228 3 +Antigen presentation folding assembly and peptide loading of class i mhc 0.261124432015668 0.0252337500348384 0.9798685168859884 1.0 1.0 17 P10321,Q03519,P04439 3 +Neddylation 0.2351651161963424 0.0241895685123149 0.980701398818449 1.0 1.0 68 P28070,Q9Y5A7,Q99436,P28072,Q06323,Q9UL46,Q99627,P28074,P49721 9 +Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.2910072714623176 0.0240874880417388 0.9807828235245823 1.0 1.0 7 P33121,O14734,Q15067 3 +Phase 0 rapid depolarisation 0.3827844799478241 0.0240316204809405 0.9808273864890138 1.0 1.0 2 Q9HD47 1 +Peptide hormone metabolism 0.2608184218255804 0.0223964513630413 0.9821317110451784 1.0 1.0 15 Q8NEW0,O60645,Q9UPT5,Q8TAD4 4 +Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 0.3661558526247139 0.0209487253885713 0.9832865578993912 1.0 1.0 2 Q96T60 1 +Downregulation of tgf beta receptor signaling 0.2938295788442744 0.0190871137395523 0.9847716113049962 1.0 1.0 6 Q9UNE7,O14980,Q9Y3F4,Q96PU5,P62136 5 +Resolution of sister chromatid cohesion 0.2433403387084246 0.0188542008625241 0.9849574154560196 1.0 1.0 61 Q96GD4,Q13885,Q29RF7,Q9NQS7,Q9BVA1,Q6P1K2,P57740,Q8NFH4,P55735,O14777,P06493,Q8WVM7,Q8NBT2,P68371 14 +Antiviral mechanism by ifn stimulated genes 0.2570428625484419 0.0173910963294347 0.9861246121825438 1.0 1.0 51 P12270,Q8N1F7,Q99567,P57740,P55735,Q8NFH4,P52292,Q8NFH5,Q9Y4X5,Q7Z3B4,Q9BTX1 11 +Tp53 regulates transcription of cell cycle genes 0.2633861512467552 0.0129873487148196 0.9896378862739068 1.0 1.0 13 Q9Y3B8,Q9UIV1 2 +Synthesis of pips at the golgi membrane 0.2782583549641706 0.0029811924298223 0.9976213561108324 1.0 1.0 5 Q9BTU6,Q10713 2 +Lipophagy 0.3206131767775567 0.0008562116564228 0.9993168420220312 1.0 1.0 3 O60664,P54619 2 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2fb9153b3ea51928047115406895496c37482616 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of caspases through apoptosome mediated cleavage", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via dependence receptors in the absence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd22 mediated bcr regulation", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular hexose transport", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Common pathway of fibrin clot formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Dectin 2 family", "Defective cftr causes cystic fibrosis", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of base excision repair", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Electric transmission across gap junctions", "Elevation of cytosolic ca2 levels", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phosphoinositide 3 kinase pi3k", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Erythropoietin activates stat5", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acids bound to gpr40 ffar1 regulate insulin secretion", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr activation", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of cell cycle genes", "Foxo mediated transcription of cell death genes", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 processing", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Na cl dependent neurotransmitter transporters", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr regulates axonogenesis", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Ras signaling downstream of nf1 loss of function variants", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in bcr signaling", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of keratinocytes", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx1 regulates transcription of genes involved in interleukin signaling", "Runx1 regulates transcription of genes involved in wnt signaling", "Runx2 regulates bone development", "Runx2 regulates chondrocyte maturation", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates bcl2l11 bim transcription", "Runx3 regulates cdkn1a transcription", "Runx3 regulates immune response and cell migration", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgf beta receptor complex in cancer", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of immune response proteins", "Sumoylation of intracellular receptors", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 24 hydroxycholesterol", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc efflux and compartmentalization by the slc30 family", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3B", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATR", "ATRX", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDHA", "BCKDK", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRD1", "BRD2", "BRD4", "BSG", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "CAB39", "CABIN1", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC22", "CCDC59", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CDS2", "CENPF", "CENPI", "CENPP", "CERS1", "CERS2", "CETN2", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLINT1", "CLNS1A", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "COG4", "COG6", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPM1", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFNB1", "EFTUD2", "EHD1", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF2", "FAM114A2", "FAM3C", "FAM49B", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP14", "FKBP1A", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTA", "FNTB", "FOXK1", "FOXO3", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP2", "GTPBP3", "GUSB", "GYS1", "H1F0", "H2AFX", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAM3", "JUP", "KARS", "KAT7", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LRPPRC", "LRRC41", "LRRC8A", "LRRC8C", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LYN", "LYPLA1", "M6PR", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAN2A1", "MAN2B1", "MANF", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MAPRE1", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "METAP1", "METTL1", "MFAP1", "MFN1", "MFN2", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MIPEP", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MPV17", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO5A", "MYO6", "NAA35", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NARS2", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEK9", "NELFA", "NELFCD", "NELFE", "NF1", "NFKB2", "NGEF", "NHLRC2", "NHP2", "NIP7", "NISCH", "NIT2", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PAK4", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUS1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP5", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIOX2", "RIPK1", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP7A", "RRP8", "RRP9", "RSF1", "RSU1", "RTCB", "RTF1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMDT1", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX17", "STX18", "STX3", "STX4", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SYMPK", "SYNE2", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAP2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED10", "TMED5", "TMED7", "TMED9", "TMEM30A", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMX3", "TNPO1", "TOLLIP", "TOMM22", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRMT10C", "TRMT11", "TRMT112", "TRMT61A", "TRRAP", "TSFM", "TSG101", "TSN", "TSPO", "TSR1", "TST", "TSTA3", "TTC21B", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS25", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WBP11", "WDCP", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YEATS4", "YIF1A", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZCRB1", "ZFYVE16", "ZMYM2", "ZNF512B", "ZNF638", "ZW10"], "leading_proteins": ["AAMP", "ABCB1", "ABCB7", "ABCC4", "ACAT2", "ACBD3", "ACBD5", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADD1", "ADD3", "AGPS", "AHCYL1", "ALDH3A2", "ANAPC16", "ANAPC5", 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0.0693300967684576 +Cholesterol biosynthesis with skeletal dysplasias 1 5 2.1960360410904145 0.0280893638196217 2.703883495145631 6.024271844660194 1.6250539245333766 0.1427602110791373 1.3052115351448448 0.7101163612316155 0.9675759117714408 0.205892393525391 0.0043013897909774 0.0325017468768143 0.0017865936405575 0.0110635085303117 0.0418361746391697 +Statin inhibition of cholesterol production 2 5 2.093609234478963 0.0362948042733666 2.0315533980582523 5.029126213592233 1.044092701346018 0.2144191485801186 1.2890406286437517 1.2084356467042294 1.2621579412510306 0.2395890160394713 0.0174236271954414 0.0639684350193291 0.1241196507421894 0.0040529339053312 0.0276005264132961 +Sphingolipid metabolism in senescence 5 14 2.078495701771644 0.0376637263762371 4.349514563106796 11.679611650485436 1.1898351622318797 0.2087194733713789 1.8732078185138223 1.4259290429724831 1.4063103725171229 0.2533781048666968 0.0444546103480301 1.0 1.0 0.0019800602892138 0.0006251087677314 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0.1692072490812911 2.0060587839493125 1.5113078035984122 1.4254327231792938 0.2283290755268721 0.222876020213352 1.0 1.0 0.007181114657122 0.0009961752813945 +Acquired partial lipodystrophy barraquersimons syndrome 4 5 2.039704152973858 0.0413798010411177 1.7402912621359223 4.497572815533981 0.9065154927122356 0.2548673055649036 1.4953091418597944 0.5048251951988992 1.235575791841686 0.2574096858611674 1.0 1.0 1.0 0.1560011717720634 0.0001695148193701 +Vitamin a and carotenoid metabolism 2 5 1.997866065446816 0.0457311825140029 1.0606796116504855 4.106796116504855 0.9332890102257668 0.3070288768360753 0.8805930946368925 1.0255249317378814 1.0615219291263185 0.2652373693874932 0.0281942097886525 0.0814971443263516 0.0121688129697343 0.067868567873399 0.053660443290246 +Striated muscle contraction pathway 4 5 1.986743385654442 0.0469508413068959 2.344660194174758 5.334951456310679 0.5676306621192281 0.3848598361215665 1.4772204386407015 1.028450501743625 1.1508412144445943 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0000000000000000000000000000000000000000..b1c98437d5d3d214cb935b67120ec4cc817cee78 --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,133 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Metapathway biotransformation phase i and ii 0.5801306858466398 2.2294850518322487 0.025781648809082 0.9999998172548786 0.4940096578256371 21 P07099,Q86UY6,P21964,Q16850,Q6UW02 5 +Cholesterol biosynthesis with skeletal dysplasias 0.8712112831640348 2.1960360410904145 0.0280893638196217 0.999999955327226 0.5194840668116854 5 Q16850 1 +Statin inhibition of cholesterol production 0.8462515584079682 2.093609234478963 0.0362948042733666 0.9999999997096948 0.5448844944027754 5 Q07954,Q8WTV0 2 +Sphingolipid metabolism in senescence 0.6137259496661359 2.0784957017716437 0.0376637263762371 0.9999999998752178 0.5448844944027754 14 P16278,Q96G23,Q06136,Q13510,O15121 5 +Glycosaminoglycan degradation 0.8000425453259772 2.0597789936822064 0.039419673644893 0.9999999999578292 0.5448844944027754 6 P54802,P16278 2 +Ccl18 signaling pathway 0.6958738348320568 2.056483127953533 0.039735970925498 0.999999999965322 0.5448844944027754 10 P07196,P00403,P08670 3 +Sphingolipid metabolism integrated pathway 0.7191470765479476 2.050026812613897 0.0403618144002055 0.9999999999764568 0.5448844944027754 9 Q96G23,O15121,P27544,Q13510 4 +Sphingolipid metabolism overview 0.7191470765479476 2.050026812613897 0.0403618144002055 0.9999999999764568 0.5448844944027754 9 Q96G23,O15121,P27544,Q13510 4 +Acquired partial lipodystrophy barraquersimons syndrome 0.8332245430809484 2.039704152973858 0.0413798010411177 0.9999999999874668 0.5462133737427538 5 Q03252,O60725,P02545,P49354 4 +Vitamin a and carotenoid metabolism 0.8231636049852995 1.997866065446816 0.0457311825140029 0.9999999999991598 0.5796549804729106 5 Q8WTV0,O94788 2 +Striated muscle contraction pathway 0.820496083550912 1.986743385654442 0.0469508413068959 0.9999999999996068 0.5810166611728377 5 O43707,P08670,P67936,P06753 4 +Influence of laminopathies on wnt signaling 0.6445969762806235 1.918829402335429 0.0550059275083039 0.9999999999999974 0.60031688755086 11 O75844,O60725,P02545,P49354 4 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.8711945856711745 1.9146313481061223 0.0555395343751159 0.9999999999999982 0.60031688755086 4 P09601,P07099 2 +Oxidation by cytochrome p450 0.7602185003969257 1.8857218604114343 0.0593324454760668 1.0 0.6171818588661745 6 O43169,Q16850 2 +Pregnane x receptor pathway 0.7919181792242054 1.8668134034753885 0.0619276500778753 1.0 0.6171818588661745 5 P08183 1 +Intracellular trafficking proteins involved in cmt neuropathy 0.6340688527173691 1.8616631445495144 0.0626505866440161 1.0 0.6171818588661745 11 Q9NR77,P07196 2 +Ketogenesis and ketolysis 0.7536036412168278 1.8565118988095304 0.0633806286041021 1.0 0.6171818588661745 6 P53985,O43772 2 +Genes related to primary cilium development based on crispr 0.6768081328427485 1.8409812206286775 0.0656243107487695 1.0 0.6220856208077474 9 Q7Z4L5,O95684,A0AVF1 3 +Sphingolipid pathway 0.66948830952815 1.8043817124821733 0.0711714879123337 1.0 0.6263085260271612 9 Q96G23,Q06136,Q13510 3 +Degradation pathway of sphingolipids including diseases 0.7413655967013161 1.8022544744426616 0.0715053776197256 1.0 0.6263085260271612 6 P06865,P06280,P16278,O43681 4 +Nocgmppkg mediated neuroprotection 0.7242886629104887 1.7260878648277622 0.0843316066643555 1.0 0.6263085260271612 6 P07196 1 +Ferroptosis 0.4816200651250503 1.7208884650576015 0.0852710651297199 1.0 0.6263085260271612 24 P37268,Q9Y277,Q15043,Q9UKU0,P09601,Q96QD8,P02786,P32929,P45880,P16435 10 +Endothelin pathways 0.6694467016640974 1.7201470885612935 0.0854057080946129 1.0 0.6263085260271612 8 P42892 1 +1q211 copy number variation syndrome 0.6515367613201928 1.7140760990742991 0.0865147507064445 1.0 0.6267044136540006 9 Q9NPH0 1 +Cholesterol biosynthesis pathway 0.6053347833637899 1.7040171428630733 0.0883778846245337 1.0 0.6294304132295692 11 P37268,Q15800,Q16850 3 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.5044247555106574 1.6978764403150632 0.0895310847379524 1.0 0.6294304132295692 21 Q9BWD1,Q15800,Q15392,Q16850 4 +Mecp2 and associated rett syndrome 0.5394834416211767 1.695028530547931 0.0900700086271268 1.0 0.6294304132295692 16 P31943,P35637,P52597 3 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.5381361896420397 1.6863147168391526 0.091735197919837 1.0 0.6336128786556189 16 O60725,P02545,P49354,O75844,P55209 5 +Mitochondrial complex iii assembly 0.6002779887579096 1.6760379160774164 0.09373076604105 1.0 0.6393437808563658 11 P22695,Q9UDW1,Q6DKK2 3 +Thermogenesis 0.4675323147856722 1.62081455938823 0.1050574150721821 1.0 0.6719935826197657 28 O43772,P23786,P51812,Q15418,Q9UKU0 5 +Allograft rejection 0.6256492691857214 1.5825521956423505 0.1135235666645333 1.0 0.6790447850422259 9 P10321,P08183,P08670 3 +Familial hyperlipidemia type 3 0.96609064232149 1.5722593275422745 0.1158904214671427 1.0 0.6790447850422259 2 Q8WTV0 1 +G protein signaling pathways 0.5080397731487484 1.5706570139037104 0.1162623390585406 1.0 0.6790447850422259 18 Q92667,O60658,Q14344,P13861,P09471,O43823,Q9UBI6,P29992 8 +Tyrobp causal network in microglia 0.7798942349138123 1.5467999289463208 0.1219114973677595 1.0 0.6790447850422259 4 Q15418 1 +Hostpathogen interaction of human coronaviruses mapk signaling 0.6463485306502479 1.533215313803543 0.1252228122963736 1.0 0.6790447850422259 7 Q15418 1 +Mitochondrial complex iv assembly 0.5588693391380657 1.532302735141651 0.1254477464856198 1.0 0.6790447850422259 12 Q9Y2R0 1 +Drug induction of bile acid pathway 0.9546788392566056 1.5270671245247922 0.126744320826778 1.0 0.6790447850422259 2 P08183 1 +Folate metabolism 0.5047514567550694 1.434334351576637 0.1514768718752224 1.0 0.7375185401137877 15 P00374,Q8WTV0,P41440,P32929 4 +Ethanol effects on histone modifications 0.5636014870244481 1.3597344416015638 0.1739139749140248 1.0 0.784616799630797 10 P41440 1 +Phosphodiesterases in neuronal function 0.9141014290297612 1.3575411240844064 0.1746093358402172 1.0 0.784616799630797 3 O43924 1 +Primary focal segmental glomerulosclerosis fsgs 0.4484015405894176 1.19935086360917 0.2303915451118545 1.0 0.8194765137511474 19 Q14108,O00592,P08670,O43707,P46939 5 +Nanomaterial induced apoptosis 0.8654860555979547 1.179107718793656 0.238355285404034 1.0 0.8300900938521775 3 O95831 1 +Mitochondrial long chain fatty acid betaoxidation 0.4660987910953365 1.1568097965487751 0.2473500784711033 1.0 0.8300900938521775 14 P23786,O43772 2 +Nephrotic syndrome 0.4927170669482848 1.1436519663428355 0.2527680011454416 1.0 0.8341344037799573 12 Q7Z4L5,P02545,Q14108,O75844,O43707,O00592 6 +Heme biosynthesis 0.6150429804092451 1.1010708045524895 0.2708658424417245 1.0 0.8424129493017092 5 P36551,P22830 2 +Familial partial lipodystrophy fpld 0.5555775651110587 1.0927023450697195 0.2745245098187943 1.0 0.8424129493017092 7 O60725,P02545,P49354,O75844,Q03252 5 +Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway 0.8389305510270787 1.0711889061570377 0.284084498798266 1.0 0.8424129493017092 2 P09601 1 +Eicosanoid synthesis 0.8219758721878019 1.005699852671199 0.314559974081835 1.0 0.8554650013754505 2 P09960 1 +Omega3 omega6 fatty acid synthesis 0.5661707885573349 1.0039583021116911 0.3153987126283226 1.0 0.8554650013754505 6 O15254 1 +Zinc homeostasis 0.807240704500966 0.9678652157431794 0.3331116883481506 1.0 0.8616543376632624 3 Q15043,Q8TAD4 2 +Complement system in neuronal development and plasticity 0.5127246627195067 0.9373148650923848 0.3485966187296845 1.0 0.8880669854840477 8 Q9NR28 1 +Proximal tubule transport 0.4681259660280137 0.9290259087932864 0.352875659452998 1.0 0.8880669854840477 11 P08183 1 +Mitochondrial complex i assembly model oxphos system 0.3818210159196005 0.924809855032524 0.3550648234313796 1.0 0.8880669854840477 27 O43676,Q96CU9,O96000 3 +Male infertility 0.4073680123842369 0.9098251834189406 0.3629147112007507 1.0 0.8880669854840477 19 Q15165,P08183 2 +Methionine metabolism leading to sulfur amino acids and related disorders 0.570467444927941 0.907146600286868 0.364329277893443 1.0 0.8880669854840477 5 P55263 1 +Transcriptional activation by nrf2 in response to phytochemicals 0.6233522263696288 0.906265781253038 0.3647951926904169 1.0 0.8880669854840477 4 P09601 1 +Cohesin complex cornelia de lange syndrome 0.4214235298925487 0.8924372974231071 0.3721585872157358 1.0 0.8924192891446564 15 Q9NTI5,Q96GD4,Q29RF7,P06493,Q9Y6X3,Q9UQE7,P25054 7 +3q29 copy number variation syndrome 0.4718387917251672 0.8614036047058993 0.3890157914097258 1.0 0.8924192891446564 10 O95684,P02786 2 +Mevalonate arm of cholesterol biosynthesis pathway 0.4865607089612882 0.8611418315854277 0.3891599323359465 1.0 0.8924192891446564 9 Q9BWD1 1 +Angiopoietinlike protein 8 regulatory pathway 0.3696518211282625 0.8268148819330643 0.4083419936897563 1.0 0.8924192891446564 27 P51812,Q15418,P41440 3 +Cellular proteostasis 0.5468193249814902 0.8057875164861577 0.4203653772349143 1.0 0.8952332249480077 5 Q9UHV9 1 +Eicosanoid metabolism via lipooxygenases lox 0.5203556971156473 0.7957052073955513 0.4262033994191425 1.0 0.8966776707878029 6 Q15067,O15254,P09960 3 +Matrix metalloproteinases 0.7652429083795222 0.7920935679708749 0.4283061202314622 1.0 0.8966776707878029 2 Q9UGU0 1 +Electron transport chain oxphos system in mitochondria 0.3431334298592798 0.7875767442450128 0.4309443220928557 1.0 0.8966776707878029 51 Q9UDW1,P25705,O75964,P03915,P00846,P22695,O43676,O96000,P21912,P00403 10 +Ciliopathies 0.4054914009727423 0.7710198872935957 0.4406951438359412 1.0 0.8966776707878029 14 Q7Z4L5,O43924,Q10713 3 +Proteasome degradation 0.3555413071611344 0.7651928974733897 0.4441566883937011 1.0 0.8966776707878029 42 P28070,Q99436,P10321,P28072,Q06323,Q9UL46,P28074,P49721 8 +Mrna protein and metabolite inducation pathway by 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0.3645734318530972 0.5342721425734974 0.5931532627570943 1.0 0.921442622417188 15 Q15392 1 +Apoptosis modulation and signaling 0.3721618721539128 0.5043129830608957 0.6140414554465936 1.0 0.9226839957611614 13 O95831 1 +Small cell lung cancer 0.4227213427555707 0.500639009447605 0.6166252032149386 1.0 0.9226839957611614 8 P07942 1 +Ppar signaling pathway 0.3535524744375211 0.4825159146146088 0.6294394957348741 1.0 0.9226839957611614 16 Q9UKU0,P23786,O15254 3 +Ciliary landscape 0.3004272787763163 0.4595345068069038 0.6458503782385154 1.0 0.9226839957611614 97 O95400,A0AVF1,Q96PK6,Q99567,P33991,Q13868,P55081,Q99627,P60660,Q9UPT5,P08670,O15173,Q9H4A3,P07197,O43805,P16278,P07196,Q14566,P10619 19 +Pathogenic escherichia coli infection 0.3188448423666201 0.4500244018570298 0.6526928456176588 1.0 0.9226839957611614 24 Q13885,Q9BVA1,Q16625,Q13464,P68371,P07437 6 +Type i collagen synthesis in the context of osteogenesis imperfecta 0.3705017808073128 0.4435291552219844 0.6573830357329169 1.0 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0.715271997593486 1.0 0.9473865015269988 47 Q96GC9,Q9UDW1,O43674,O00459,P22695,O43676,O96000,P21912,P00403 9 +Eicosanoid metabolism via cyclooxygenases cox 0.4088170862926866 0.3318975979004779 0.7399665842805738 1.0 0.9486729521094396 6 O15254,Q15067 2 +Urea cycle and related diseases 0.622432344310396 0.3310552129618665 0.7406027807303088 1.0 0.9486729521094396 2 Q9Y619 1 +Alzheimers disease and mirna effects 0.2759100424563335 0.3222879039641991 0.7472345959158808 1.0 0.9486729521094396 82 P28070,Q96GC9,Q9Y277,Q13885,Q07954,Q9BVA1,O00459,Q99436,P16615,P28072,P49721,P28074,O95197,P68371,P45880,P21796,P07437 17 +Mammary gland development pathway pregnancy and lactation stage 3 of 4 0.4212802091820882 0.3181527553514767 0.7503690679389321 1.0 0.9486729521094396 5 P18031,P61201,P06753 3 +Triacylglyceride synthesis 0.4579724593263984 0.3071372760290136 0.7587388858349153 1.0 0.9486729521094396 4 Q9NUQ2,O15228 2 +Dna mismatch repair 0.3230922481045168 0.3065224856878119 0.7592068621314778 1.0 0.9486729521094396 16 P41440 1 +Ovarian infertility 0.6087381806325339 0.2960630469779747 0.7671819337888002 1.0 0.951369663195297 2 P11802 1 +Histone modifications 0.3653781088785542 0.2568533693223545 0.797291968979962 1.0 0.9728352910197778 8 Q01105 1 +Spinal cord injury 0.2981206574460005 0.2361159831241703 0.8133426717955994 1.0 0.9728352910197778 21 P14174,P62942,Q9NQC3,P06493,P08670,P27695,Q08722,O75116 8 +Tryptophan catabolism leading to nad production 0.5800456472122524 0.2296321544607504 0.8183776188153866 1.0 0.9728352910197778 2 P43490 1 +Metabolism of spingolipids in er and golgi apparatus 0.427982794151153 0.2241983923839756 0.8226029343284633 1.0 0.9728352910197778 4 Q06136 1 +Cerebral organic acidurias including diseases 0.3850631474657767 0.2068713242128452 0.8361103520366182 1.0 0.9728352910197778 5 Q9H9P8 1 +Adipogenesis 0.3054304225879759 0.2026152027974347 0.8394358063551817 1.0 0.9728352910197778 14 P14174,P02545 2 +Calcium regulation in cardiac cells 0.2861838879435094 0.1978195726868223 0.8431862319892911 1.0 0.9728352910197778 29 P62942,Q9Y3B8,P08133,P13861,P16615,Q9UBI6,Q14012 7 +Alzheimers disease 0.261936352234795 0.1873093401013968 0.8514181002489112 1.0 0.9737048634780406 80 P28070,Q9Y277,Q13885,Q07954,Q9BVA1,O00459,Q99436,P16615,P28072,P49721,P28074,O95197,P68371,P45880,P21796,P07437 16 +Kynurenine pathway and links to cell senescence 0.5559178350179237 0.1813893239006246 0.8560619981762003 1.0 0.9737048634780406 2 Q15274 1 +Physicochemical features and toxicityassociated pathways 0.2966121555753634 0.1708362760580095 0.8643525041795024 1.0 0.9766140320236972 16 P07196 1 +Egfegfr signaling pathway 0.284481745775505 0.1702505496633964 0.8648130990647556 1.0 0.9766140320236972 42 P51812,Q15418 2 +Dna replication 0.2755141428009975 0.1371840658593096 0.8908853054312746 1.0 0.9928214649515104 28 P41440,P33991 2 +Ebola virus infection in host 0.2802904121800914 0.1362390663487656 0.8916322925897873 1.0 0.9928214649515104 38 P41440,Q9P253,O00459,P04439,P10321,O43707,O15118,O75569 8 +Sterol regulatory elementbinding proteins srebp signaling 0.2719330381128248 0.1162298354050143 0.9074703917584332 1.0 1.0 28 Q8WTV0 1 +Oxidative damage response 0.4859752120025986 0.0944747513072744 0.9247320382607018 1.0 1.0 3 P60953,P12004 2 +Cytosine methylation 0.3378928268009779 0.092638097284641 0.926191076613168 1.0 1.0 5 P48735 1 +Insulin signaling 0.2730299822815881 0.0893544359774708 0.9288002333859524 1.0 1.0 41 Q15418,P41440 2 +Thyroid stimulating hormone tsh signaling pathway 0.2736848580835748 0.0853016146113009 0.9320216079392912 1.0 1.0 19 Q14344,P09471,O00459,Q15418,Q9UNY4 5 +Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement 0.3117612181431519 0.0722473436883834 0.9424050687705594 1.0 1.0 7 Q93052 1 +Sarscov2 b117 variant antagonises innate immune activation 0.4711444408216454 0.0678434815024847 0.9459102302435642 1.0 1.0 2 Q7Z434 1 +Dna damage response 0.2651324562531472 0.0551220054968267 0.9560412649434512 1.0 1.0 20 P41440 1 +Onecarbon metabolism and related pathways 0.2805016775529236 0.0495001851567658 0.9605206896484956 1.0 1.0 12 P32929,O43865 2 +Phosphoinositides metabolism 0.3094054006046422 0.0471825041567062 0.962367771651348 1.0 1.0 6 Q8TBX8,Q13614 2 +Sars coronavirus and innate immunity 0.4065862406260195 0.030605397135849 0.9755842378756197 1.0 1.0 2 Q7Z434 1 +Overview of interferonsmediated signaling pathway 0.406586240626016 0.0306053971358476 0.9755842378756208 1.0 1.0 2 P17252 1 +Smc1smc3 role in dna damage cornelia de lange syndrome 0.2913128674069166 0.024727809025111 0.9802720734647858 1.0 1.0 7 Q14683,O60216,Q9UQE7,O60934,P49959,Q92878 6 +Serine metabolism 0.2956701146607704 0.0229996733702961 0.98165053349394 1.0 1.0 5 P00374,P34897 2 +Mirna regulation of dna damage response 0.2540618210159538 0.0159031633918227 0.9873116463005304 1.0 1.0 21 P41440 1 +Ketone bodies synthesis and degradation 0.3365949119373776 0.0029586729581907 0.9976393239703214 1.0 1.0 3 P35610,P35914 2 +Sulfation biotransformation reaction 0.3336594911937336 0.0025153561069436 0.9979930383136952 1.0 1.0 3 O43252,P00390 2 +Airway smooth muscle cell contraction 0.3133281130115724 0.0001241842958768 0.9999009152678804 1.0 1.0 3 Q13464 1 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e667573a429479ca91e0282fe8e70656ea10ff3a --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoe and mir146 in inflammation and atherosclerosis", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgf23 signaling in hypophosphatemic rickets and related disorders", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Galanin receptor pathway", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthesis ii from tryptophan", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP1", "AKAP12", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1A2", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANP32A", "ANXA1", "ANXA2", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APC", "APEX1", "APMAP", "APPL1", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARL5B", "ARL8B", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AURKB", "BAG3", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAS3", "BCAT2", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BLVRA", "BLVRB", "BPTF", "BRD1", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CASK", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CERS1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHMP6", "CHORDC1", "CHRAC1", "CHTF18", "CIP2A", "CKB", "CLASP1", "CLCN7", "CLIC1", "CLPTM1L", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COA3", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COQ8A", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CRK", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAG1", "DARS", "DAXX", "DBNL", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDAH2", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEGS1", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFNB1", "EFTUD2", "EHD1", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERBIN", "ERCC2", "ERCC3", "ERI1", "ESD", "ESS2", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC2", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAM120A", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FKBP10", "FKBP1A", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXO3", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAPDH", "GART", "GBA", "GCDH", "GCLM", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNG12", "GNG5", "GNPAT", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2E2", "GTF2I", "GTPBP2", "GTPBP4", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIRIP3", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "ILF2", "IMP3", "IMPAD1", "IMPDH2", "INF2", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LAMB1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LPGAT1", "LPP", "LRP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM2", "LSS", "LTA4H", "LYN", "LYRM7", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1B", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MFAP1", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MMADHC", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPG", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTOR", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO5A", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NARS2", "NAT10", "NBN", "NCAPG", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NF1", "NFATC2IP", "NFKB2", "NGEF", "NKRF", "NME1", "NME2", "NONO", "NOP2", "NPC1", "NR3C1", "NSDHL", "NSF", "NTHL1", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "ORC3", "ORC5", "OSBPL3", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELO", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKB", "PI4K2A", "PIAS2", "PIGT", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKN1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNKP", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "QPRT", "RAB10", "RAB13", "RAB14", "RAB21", "RAB2A", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RB1", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RBPMS", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RTCB", "RTF1", "RTN3", "RTN4", "RUVBL1", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARS", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC13", "SEC23A", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT2", "SHOC2", "SIN3A", "SIRT1", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SNAP23", "SNAP29", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORT1", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSNA1", "SSR4", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STRAP", "STRN", "STUB1", "STX3", "STX4", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE2", "TAB1", "TALDO1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCF20", "TCP1", "TDP2", "TECR", "TELO2", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMED10", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPM4", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT2A", "TRRAP", "TSG101", "TSPO", "TTC19", "TTC21B", "TTC26", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TXNDC5", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBR5", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UPF1", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS18", "VPS33A", "VPS4A", "WARS", "WDCP", "WDHD1", "WDR1", "WDR5", "WNK1", "XAB2", "XIAP", "XPC", "XPNPEP3", "XPO1", "XPO5", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ACAT2", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADK", "AGPAT5", "AHCYL1", "AIFM1", "AKAP1", "AKAP8", "ALDH1A2", "ANXA6", "APC", "APEX1", "ARL2", "ASAH1", "ASNA1", "ATP2A2", "ATP5A1", "ATP5L", "ATP6", "AURKB", "BCAS3", "CAMK1", "CCAR2", "CD2BP2", "CD47", "CDC42", "CDK1", "CDK4", "CERS1", "CERS2", "CETN2", "COA3", "COMT", "COPS2", "COPS8", "COQ8A", "COX2", "CPOX", "CPT2", "CRTAP", "CTH", "CTSA", "CYB5B", "CYP20A1", "CYP51A1", "DEGS1", "DHCR24", "DHFR", "DIABLO", "ECE1", "EMD", "EPHX1", "EPHX2", "EXOC7", "EXOSC2", "FDFT1", "FECH", "FGFR1OP", "FKBP1A", "FNTA", "FOXRED1", "FUS", "GLA", "GLB1", "GNA11", "GNA13", "GNAO1", "GNG12", "GNPAT", "GSR", "HDAC2", "HEBP1", "HEXA", "HGS", "HLA-A", "HLA-C", "HMGCL", "HMOX1", "HNRNPD", "HNRNPF", "HNRNPH1", "ICMT", "IDH2", "KDSR", "KMT2A", "L2HGDH", "LAMB1", "LMNA", "LMNB2", "LPP", "LRP1", "LTA4H", "MAU2", "MAVS", "MCM4", "MCM6", "MFAP1", "MIF", "MRE11", "MSMO1", "MTMR2", "MYL6", "NAA40", "NAGLU", "NAMPT", "NAP1L1", "NBN", "ND5", "NDUFB10", "NDUFB3", "NDUFB5", "NEFL", "NEFM", "NELFA", "NELFE", "NONO", "NPC1", "NUP88", "OCLN", "P3H1", "P4HA1", "P4HA2", "PAPSS1", "PCNA", "PDCD6IP", "PDE6D", "PDE8A", "PDS5A", "PDS5B", "PFDN2", "PGRMC2", "PIK3R2", "PIP4K2C", "PMPCA", "PODXL", "PON2", "POR", "PRKAR2A", "PRKCA", "PRKRA", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSME1", "PSME2", "PSPC1", "PTPN1", "PXMP2", "QPRT", "RAB5B", "RAD21", "RAD50", "RBM14", "RBM4", "REXO2", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RTN3", "RTN4", "SAMHD1", "SCARB1", "SCARB2", "SDHB", "SET", "SFPQ", "SHMT2", "SLC16A1", "SLC19A1", "SLC25A15", "SLC25A20", "SLC30A5", "SLC38A2", "SLC39A14", "SLC3A2", "SMC1A", "SMC3", "SOAT1", "SSNA1", "TCF20", "TFRC", "TPM3", "TPM4", "TTC19", "TTC21B", "TTC26", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "UBTF", "UQCR10", "UQCRC2", "UTRN", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS18", "WNK1", "ZMPSTE24"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/opencell_localization/basic/idx2term.json b/opencell_localization/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..5d2236da970077dc33a5d714c4d6a4f0ee4ebc99 --- /dev/null +++ b/opencell_localization/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "er", "1": "nuclear_punctae", "2": "cytoskeleton", "3": "vesicles"} \ No newline at end of file diff --git a/opencell_localization/basic/plot_0.png b/opencell_localization/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c137a3c524c3550607ede433149609c7104e6aa7 --- /dev/null +++ b/opencell_localization/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0f67718f210928f34e10a288c65dc7a32d4c3cdda204b5649e8c73594d45778f +size 138440 diff --git a/opencell_localization/basic/plot_1.png b/opencell_localization/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..15a939f016267ac0763914e79a6d84fe2f23cf60 --- /dev/null +++ b/opencell_localization/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f5e5a3d72d184c791d5d1d4b7d08dcf6e07ed568210d48021688a5af1539e673 +size 147491 diff --git a/opencell_localization/basic/plot_2.png b/opencell_localization/basic/plot_2.png new file mode 100644 index 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0000000000000000000000000000000000000000..c11b7d2859c6fd34b05a10fa2a3e3a1e45a566d0 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 91.58823529411765 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..268daa476b22f7dbe73604c8ef260dea939cd251 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6c7dac72f2d15ad32d1be702b62f70f6744cdc57 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,7 @@ 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pval_50 pval_100 pval_250 pval_500 +transporter 21 61 3.806659510651124 0.0001408564571099 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 1.1027028129131372e-06 0.0002108857696139 1.3520097075239244e-05 4.170619808020749e-06 3.48366081811395e-08 +serine protease 5 16 2.902586878711422 0.0037009449063976 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 7.612781239454993e-05 0.0221752921749746 0.0011305823171555 0.0010432726477128 0.0088173905438192 +oxygenase 3 7 2.7437749435836 0.006073716228125 3.138349514563106 6.771844660194175 1.5409868347565758 0.1477866581414416 1.2914149665013366 1.041089559555361 1.2379399582807478 0.2357869798067575 0.0050357755542779 0.0001849020150097 0.0014183751228366 0.0023319502763363 0.0267540631687978 +protein modifying enzyme 6 21 2.4727750990853945 0.0134068483913516 6.487864077669903 24.82281553398058 0.9737051724681342 0.3238157719208961 2.575528657386725 2.871041189126622 1.1448244681235864 0.2930923238696635 0.0103227368644843 0.2400196775334175 0.0171810218627354 0.0123143017475686 0.0212959388086313 +membrane trafficking regulatory protein 2 15 2.412655468180098 0.0158367817596096 4.949029126213592 18.78640776699029 1.0645815505395402 0.2320552342124929 2.3097144002673033 2.893415643517755 1.4460865220385617 0.2677048300346334 0.1831207464952357 0.0256777347862131 0.0887791366891333 0.1331815852696937 0.4773875923121229 +ATP-binding cassette (ABC) transporter 3 6 2.3394416360877552 0.0193125888198713 2.686893203883495 7.684466019417476 0.6951371488068213 0.3450534093319853 1.8332217537175712 2.163791049328932 1.0940500371142112 0.2754733493972692 0.0444546103480301 1.0 0.195727907115695 0.0019800602892138 0.0231565450655555 +transmembrane signal receptor 4 7 2.2982962199520203 0.0215449354553434 3.266990291262136 7.169902912621359 1.6693846681257831 0.1085289610325799 1.5770125590990791 1.7927217985188668 1.0928815816574815 0.16461969248918 0.1535160677264411 0.3534387593845476 0.2147090648302901 0.1783072607259342 0.4623165903206775 +metalloprotease 11 27 2.280600267288527 0.0225721114758281 8.58495145631068 26.398058252427184 1.4262736372921438 0.246779453311036 3.321022586051017 1.6463540525991265 1.1083706824215755 0.2918245458017476 0.0448918231769796 0.225458320485449 0.0141874949182814 0.1386719925032711 0.0010356106420026 +calcium-binding protein 3 6 2.111824727324483 0.0347014855568634 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 1.0 1.0 0.0009048869233579 +lyase 3 11 1.9799369976292465 0.0477106084668585 3.2402912621359223 12.74271844660194 0.3050812839887737 0.503016525888727 2.2775877020235877 1.7325609274509297 0.9057139779162662 0.2840421755921495 0.0004475037888901 0.0060764540616979 0.0016008508165985 0.0027246216264189 0.0062087405568419 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..431ddd01a3d3fc7546671143e2f912842762eebd --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 160, + "title": "Average number of proteins per term", + "value": 13.2 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c87382aab1f6fba8f609b330d1dc69face557d1c --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..006ba0e7eb78c9624f1de83422f69b06010d4899 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,54 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +transporter 0.5992785356249586 3.806659510651124 0.0001408564571099 0.0222865233484561 0.0225370331375886 61 Q9H2V7,Q9HD45,Q9NR77,Q99595,O43772,P39210,Q99567,Q15070,Q7Z3B4,Q9Y584,O60830,Q567V2,Q99805,Q92973,P53985,Q6N075,P41440,P62072,Q8NFH4,Q8N1F7,O43681 21 +serine protease 0.7382706138434726 2.902586878711422 0.0037009449063976 0.4474711642612558 0.1763722452957476 16 Q9HB40,P42785,Q9H3G5,P10619,O14773 5 +oxygenase 0.9145105940597642 2.7437749435836 0.006073716228125 0.6227162806485912 0.1763722452957476 7 P30519,P09601,Q16850 3 +protein modifying enzyme 0.6161698054059386 2.4727750990853945 0.0134068483913516 0.8846293232379113 0.1763722452957476 21 Q92791,P50897,Q9UMR5,P51812,Q15418,O15460 6 +membrane trafficking regulatory protein 0.6626283813424332 2.412655468180098 0.0158367817596096 0.9222427712790614 0.1763722452957476 15 Q14108,Q8WTV0 2 +ATP-binding cassette (ABC) transporter 0.8656257633459856 2.3394416360877552 0.0193125888198713 0.9558535214914572 0.1766421118942693 6 O15439,Q03519,P08183 3 +transmembrane signal receptor 0.8115515386202466 2.2982962199520203 0.0215449354553434 0.969342150840406 0.1805768918066252 7 Q99720,Q96GC9,Q8WUJ1,Q9UMX5 4 +metalloprotease 0.5533038542002049 2.280600267288527 0.0225721114758281 0.9740847009547122 0.1805768918066252 27 Q7Z2K6,Q8IYS1,O43847,P22695,O75844,P53582,P02786,Q5JRX3,P55786,P42892,Q9UIQ6 11 +calcium-binding protein 0.8120931525833728 2.111824727324483 0.0347014855568634 0.9964855120991692 0.2220895075639262 6 P08133,P09525,P20073 3 +lyase 0.6559189143932045 1.9799369976292465 0.0477106084668585 0.9995991042858738 0.2827295316554583 11 Q9UHG3,P22830,Q9BU89 3 +calmodulin-related 0.632946603019313 1.9554753663542104 0.0505269881387555 0.9997504141529744 0.2887256465071746 12 O43852,Q8IYU8,P80303,Q02818,Q14257,Q9BPX6 6 +ATP synthase 0.5322881875395373 1.8377732186084452 0.0660958295563176 0.99998228380847 0.341139765451962 20 Q93050,O75964,Q9Y487,P00846 4 +tubulin 0.7725178511843972 1.7846219961867034 0.074322651093285 0.9999956992729044 0.3524863716479608 5 Q9BVA1,P68371,P07437 3 +secondary carrier transporter 0.5461222074872 1.7803326677314542 0.0750215338927864 0.9999961888190644 0.3524863716479608 17 Q15043,Q6NT16,Q9BQT8,Q96ES6,Q9Y6M7,Q9UBX3 6 +heterotrimeric G-protein 0.6755440794846832 1.7498756265591409 0.0801397772773238 0.9999984314648016 0.3524863716479608 8 Q14344,Q9UBI6,P09471,Q8NHH9 4 +oxidoreductase 0.4568742462422058 1.73377918301779 0.0829572706094736 0.9999990398667308 0.3524863716479608 44 O95831,O43169,P03915,O15254,O43676,O96000,P00403,Q8N0U8,Q8N4Q0 9 +primary active transporter 0.4950719069165113 1.6895271388849775 0.0911184555547339 0.9999997702975796 0.3738193048399342 22 P12270,P35670,Q8N4H5,O75381,Q9H2J7,P16615,Q9NS69 7 +major histocompatibility complex protein 0.8008712411434151 1.632152094535959 0.1026474497238472 0.9999999702082356 0.4105897988953888 4 P10321,P55899 2 +phosphodiesterase 0.6657941413409472 1.461589019392984 0.143853865214641 0.9999999999838688 0.4664898534876174 6 O43924 1 +protein-binding activity modulator 0.6967684385796884 1.458476497182855 0.1447092487545727 0.9999999999862532 0.4664898534876174 5 Q9UNN8,O14530,O14737 3 +nucleic acid metabolism protein 0.7510603588907012 1.4288727680950524 0.1530408057131551 0.9999999999971292 0.4664898534876174 4 Q9Y2W1,Q9NYF8,P49750 3 +acyltransferase 0.4806070171997139 1.4260590881488575 0.1538512867926185 0.999999999997537 0.4664898534876174 19 Q9BWD1,Q8NCC3,P49354 3 +kinase 0.4975445617931641 1.4211008393054654 0.155287446045756 0.9999999999981232 0.4664898534876174 16 Q8WVC6,Q9BRR6,Q9HA64,Q8TBX8,P22392,P15531 6 +glycosidase 0.686496644670609 1.4137329545953945 0.1574403255520708 0.9999999999987524 0.4664898534876174 5 Q9BTY2,P06865,P04066 3 +amino acid transporter 0.6667298682682592 1.3273994221355367 0.1843765907568193 0.9999999999999932 0.5175483249314227 5 P30825,Q96QD8 2 +methyltransferase 0.5530539636477675 1.3025908307312564 0.1927144898391388 0.9999999999999988 0.5316261788665899 10 P21964,Q8N6R0 2 +SNARE protein 0.5094298453429226 1.2423847167319948 0.2140946517688575 1.0 0.5583694099299021 12 O95249,Q86Y82,Q9P2W9 3 +voltage-gated ion channel 0.8820611536793488 1.2398299807553832 0.2150382865718714 1.0 0.5583694099299021 3 P45880 1 +oxidase 0.493856962156203 1.236243283038612 0.216368146347837 1.0 0.5583694099299021 13 Q6ZRP7,P36551,Q8NB78,Q15800,P50336 5 +galactosidase 0.8402347570916348 1.0762496070565857 0.2818156393015385 1.0 0.6373314607925026 2 P16278 1 +decarboxylase 0.8161069448973002 0.9831744274778992 0.3255215984528909 1.0 0.651450321583691 2 P14174 1 +DNA glycosylase 0.8095859145744979 0.9582437627991984 0.3379398543215397 1.0 0.651450321583691 2 P78549 1 +G-protein coupled receptor 0.7915781876855078 0.9119628280965212 0.3617882857791841 1.0 0.689120544341303 3 Q5VW38 1 +phospholipase 0.5425658599729437 0.896105768139735 0.3701962766781879 1.0 0.6891758472890406 6 Q8IV08 1 +extracellular matrix protein 0.6148293446278761 0.8720404436906556 0.3831863143817489 1.0 0.6967023897849979 4 P55081 1 +kinase modulator 0.4984832609749362 0.8160134108724655 0.4144924655263824 1.0 0.7190687617201628 7 P13861,Q93052,P67870,O00459 4 +cell adhesion molecule 0.724776974404618 0.681011097632071 0.4958644683750608 1.0 0.7933831494000974 3 O00592 1 +glycosyltransferase 0.3713935168816378 0.6347499359698437 0.5255915197329624 1.0 0.7975824231427695 18 P46977,Q10472,Q86SF2,Q8NAT1,Q9BT22,Q8TCJ2,P04843 7 +esterase 0.477635845033426 0.6077504068855794 0.5433530257660117 1.0 0.7975824231427695 6 Q969T7,Q9NUJ1 2 +viral or transposable element protein 0.6922677620927769 0.574934433455929 0.5653356411341695 1.0 0.8070761410534982 3 Q9NUD5 1 +tight junction 0.6902510596674274 0.531415729359349 0.5951307239392394 1.0 0.8155760915263384 2 Q9UDY2 1 +scaffold/adaptor protein 0.2906801219587995 0.5050265370405307 0.6135401974474157 1.0 0.8181236966101514 81 P07602,Q96F07,Q5BKZ1,Q14168,P57105,Q92796,O14936,Q9UQB8,O43823,Q12959,O95219,Q9Y2W6,Q96GI7,Q9ULX6,Q99627,Q9NZW5,Q8TDW0,Q14BN4 18 +protease 0.3252340661297253 0.4786797496727619 0.6321664741597752 1.0 0.8321198038825233 39 P28070,O75976,Q99436,P28072,P49721 5 +aspartic protease 0.648190414085422 0.4021780995479433 0.6875529586385931 1.0 0.848472578944327 2 Q5TDH0 1 +RNA methyltransferase 0.3343035643828536 0.302107393263552 0.7625701966132377 1.0 0.909872090329822 13 Q96FX7 1 +hydrolase 0.295383773395781 0.280545599426014 0.779058946135516 1.0 0.909872090329822 25 Q96AB3,O60502,P07099 3 +ion channel 0.4052698414065393 0.2666906933341084 0.7897073201230431 1.0 0.909872090329822 5 Q9C0H2 1 +guanyl-nucleotide exchange factor 0.3602385850759751 0.2594762459214925 0.7952678075625133 1.0 0.909872090329822 9 Q9HCU5,Q14C86,Q14185,Q9Y4G8,Q8TEU7,Q8N5V2 6 +chaperone 0.2570316089021286 0.2583483440952499 0.7961380790385941 1.0 0.909872090329822 67 P78318,Q8IXB1,P46379,Q99615,Q96BP3,O15260,Q9H7H0,O60884,P61758,P31689,Q96KC8,Q9Y2R0,Q15006,Q8N183,Q9NWM8,Q9Y680,Q96JJ7,P62942,Q5TC12,Q9UHV9 20 +RNA splicing factor 0.2639036863200413 0.2083889146877633 0.8349253111404966 1.0 0.9341821663110452 80 P52272,P52597,Q13243,O95400,Q96PK6,P31943,Q9UHX1,Q13242,Q9BWF3,O75525,P55795,Q8IWZ8,Q6IQ49,Q96PU8,O75934,P31942,Q07955,Q07666,Q16629,Q8WWY3,O75494 21 +membrane traffic protein 0.2504339810148225 0.1430001747335544 0.8862900431940393 1.0 0.975487771882336 64 O14976,Q9BRG1,Q08379,P11717,O60645,Q9Y2T2,A6NIH7,Q9UI14,P40855,P43307,Q00765,P50570,Q92734,Q9HD42,Q9H6H4,Q8N1B4,P49257,Q9UPT5,Q96PC5,Q99747,Q8WUM4,Q9Y296,P20645,Q99523,P51572,Q96A65 26 +DNA helicase 0.3042483660130739 0.0636819134867709 0.9492235064581176 1.0 1.0 9 P28370,Q9H4L7,O60264,P12956,P19447,P18074,P51532,P13010 8 +kinase inhibitor 0.3975864318329984 0.020669308651739 0.9835094519355384 1.0 1.0 3 Q9NQG5,Q96P16 2 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..6bd74b65afe30ee40de7adcac6c8cd8d246163ac --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "Rel homology transcription factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "antimicrobial response protein", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "hydroxylase", "immunoglobulin superfamily cell adhesion molecule", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "membrane-bound signaling molecule", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase inhibitor", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AGPAT5", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "ANAPC1", "ANAPC7", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APPL1", "APRT", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL5B", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATAD5", "ATG3", "ATG7", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BAG6", "BAIAP2", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDHA", "BCKDK", "BCLAF1", "BCR", "BDH2", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPHL", "BPNT1", "BRD1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKN2AIP", "CDS2", "CEBPZ", "CENPB", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHERP", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT7", "CNP", "COA3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAM3C", "FAM89A", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDE1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS2", "GLA", "GLB1", "GLCE", "GLDC", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOPC", "GOSR1", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GUF1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "ISOC1", "ISOC2", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LENG8", "LETM1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LYAR", "LYPLA1", "LYPLAL1", "LYRM7", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MAT2B", "MBLAC2", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIF4GD", "MIPEP", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MORF4L2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTF2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCDN", "NCOA5", "ND5", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NENF", "NF1", "NFKB2", "NGEF", "NHP2", "NIP7", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PHKB", "PI4K2A", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSMF1", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIOK2", "RIPK1", "RNASEH2A", "RNF2", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTN4IP1", "S100A11", "S100A13", "SACM1L", "SAE1", "SAMHD1", "SAP130", "SAP18", "SAP30", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMN1*", "SMNDC1", "SMPD4", "SNAP23", "SNAP29", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAP2", "TARBP1", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TES", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMOD1", "TMOD3", "TMPO", "TMX2", "TMX3", "TNPO1", "TNPO3", "TOE1", "TOMM22", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1B", "TP53", "TP53BP1", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAP1", "TRAPPC4", "TRIM21", "TRIM24", "TRIM26", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TST", "TSTA3", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBR5", "UBTF", "UCHL5", "UCK2", "UFL1", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UPF2", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP6", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VKORC1L1", "VMP1", "VPS13D", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WASHC5", "WDHD1", "WDR1", "WDR33", "WDR82", "WIZ", "WNK1", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YEATS4", "YLPM1", "YME1L1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZCCHC3", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF207", "ZNF277", "ZNF281", "ZNF326", "ZNF598", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABHD10", "ACAT2", "ACOX3", "ADPGK", "AIFM1", "AKAP8", "AKAP8L", "ALG1", "ANXA4", "ANXA6", "ANXA7", "AP3M1", "ASNA1", "ATL2", "ATP2A2", "ATP5L", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP7B", "ATPAF1", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCLAF1", "CALU", "CASK", "CD2BP2", "CHMP1A", "COA3", "COMT", "COPS8", "COX2", "CPD", "CPOX", "CPVL", "CSNK2B", "CTSA", "CYB5B", "CYB5D2", "CYFIP2", "CYP51A1", "DCAKD", "DDI2", "DLG1", "DLG3", "DNAJA1", "DNAJA2", "DNAJC1", "DNAJC10", "DNAJC7", "DNM2", "DOCK1", "DOHH", "ECE1", "EMC2", "EPHX1", "ERCC2", "ERCC3", "ERMP1", "EXOC3", "EXOC4", "EXOC7", "FAM89A", "FCGRT", "FECH", "FKBP14", "FKBP1A", "FKBP7", "FN3KRP", "FNTA", "FUCA1", "FUCA2", "GAK", "GALNT1", "GALNT7", "GAPVD1", "GLB1", "GNA13", "GNAO1", "GNG12", "GOLGA2", "GOSR1", "GPR107", "HEXA", "HLA-C", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPM", "IGBP1", "IGF2R", "ISOC2", "KDM1B", "KHDRBS1", "KHDRBS3", "LMAN1", "LNPEP", "LPP", "LRRC8C", "M6PR", "METAP1", "METTL13", "METTL17", "MFAP1", "MFSD3", "MFSD5", "MGEA5", "MIA2", "MICU1", "MICU2", "MIF", "MPP2", "MPP6", "MPV17", "MPV17L2", "MSMO1", "NAPG", "ND5", "NDUFAF2", "NDUFB10", "NDUFB3", "NENF", "NGEF", "NME1", "NME2", "NPEPPS", "NRDC", "NT5C3B", "NTHL1", "NUCB1", "NUCB2", "NUP37", "NUP54", "NUP88", "NUP93", "OXA1L", "P3H4", "P4HA2", "PCYOX1", "PDCD5", "PDCD6IP", "PDE6D", "PEX14", "PEX19", "PFDN2", "PIK3R2", "PIP4K2C", "PITRM1", "PLA2G15", "PLD3", "PM20D2", "PODXL", "POMGNT2", "PPOX", "PPT1", "PPT2", "PPWD1", "PRCP", "PREB", "PRKAR2A", "PROCR", "PRPF31", "PSAP", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PUF60", "PXMP2", "QKI", "QSOX2", "RABAC1", "RAPGEF2", "RAPGEF6", "RBM14", "RBM4", "RCN2", "REEP4", "REEP5", "RPN1", "RPRD1A", "RPRD1B", "RPS6KA1", "RPS6KA3", "SCARB1", "SCARB2", "SCPEP1", "SDE2", "SIGMAR1", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A20", "SLC25A21", "SLC38A2", "SLC39A14", "SLC4A7", "SLC6A15", "SLC7A1", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SNX4", "SORT1", "SPNS1", "SRSF1", "SRSF10", "SRSF5", "SRSF7", "SRSF9", "SSR1", "STT3A", "STT3B", "STX12", "STX18", "SUGP1", "SURF4", "SYNJ2BP", "TAP2", "TDRKH", "TFG", "TFRC", "THRAP3", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TJP2", "TM9SF2", "TM9SF3", "TMX3", "TNPO1", "TOMM22", "TOMM5", 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0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.001174462213825 0.1403531442218371 0.0362367738259921 0.000894192473748 1.4117088359037986e-05 +Intracellular calcium-sensing protein 9 14 2.0780527617228985 0.0377044998294893 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.001174462213825 0.1403531442218371 0.0362367738259921 0.000894192473748 1.4117088359037986e-05 +Oxygenase 0 5 2.001114529246384 0.0453800489316913 1.325242718446602 5.089805825242719 0.6977327730253281 0.3871728673651154 1.2525871050154007 0.6417459204185357 0.96253954683313 0.2912793467281958 0.187489594626983 0.0639684350193291 0.1241196507421894 0.2877500137996227 0.501296209728951 +F-type and V-type ATPases 2 16 2.00005172176222 0.0454946791693537 4.995145631067961 15.616504854368932 0.6819760311565471 0.3553057475304781 2.5561606009064737 1.187932616128487 1.149561543758102 0.2999604229905949 0.0044538316588348 0.0001623251751115 0.001249562324504 0.0168339060908118 0.0042587077964903 +Extracellular structure 4 9 1.9679374228650983 0.049075238265853 2.842233009708738 8.092233009708737 0.8560017356043709 0.3472532488838395 1.4285109580808126 1.0866524100509705 0.962827743376652 0.290186194394739 1.0 1.0 1.0 0.1275304084592042 0.0073870683046854 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..970507619f45d0ff50339332976cfcd584543676 --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 1989, + "title": "Average number of proteins per term", + "value": 3.1060834590246356 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..697f1869752b370c30f5239715ecde4a3ce5c8b5 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e6e98ce419c15ea3d817393aaeabdad3455fbe19 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,73 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.6337680098942275 2.877002095582163 0.0040147292915053 0.9996649963045068 0.1209225097505581 28 Q9NR77,Q567V2,P20645,Q14108,O75381,P57105,Q8WTV0,P39210,Q9UQB8,Q96GI7,A6NIH7 11 +SLC superfamily of solute carriers 0.5714277800811712 2.835591279679554 0.0045740941898921 0.9998904077915276 0.1209225097505581 47 Q9H2V7,P41440,Q8TAD4,O43772,Q6NT16,P30825,Q8IXU6,Q9BQT8,P53985,Q9UBX3,Q6N075,Q70HW3 12 +ATP-binding cassette transporter family 0.8656257633459856 2.3394416360877552 0.0193125888198713 1.0 0.1215714223034768 6 O15439,Q03519,P08183 3 +Calcium-binding protein 0.6125103874075649 2.2061701567083234 0.0273720879880743 1.0 0.1336951208024213 17 Q8N163,P43307,Q8IYU8,P80303,P41208,O43852,Q02818,Q14257,Q9BPX6 9 +Signaling 0.5974035774540727 2.1627496435533176 0.0305604405829649 1.0 0.1394028686017931 18 Q96GC9,Q8WUJ1,O15173,O00264,Q96PC5,Q99627,Q7Z4V5 7 +Calmodulin 0.6136521506985305 2.0780527617228985 0.0377044998294893 1.0 0.1489498809699023 14 P60660,Q8N163,O43852,Q8IYU8,P80303,P41208,Q02818,Q14257,Q9BPX6 9 +Intracellular calcium-sensing protein 0.6136521506985305 2.0780527617228985 0.0377044998294893 1.0 0.1489498809699023 14 P60660,Q8N163,O43852,Q8IYU8,P80303,P41208,Q02818,Q14257,Q9BPX6 9 +F-type and V-type ATPases 0.5873111023489137 2.00005172176222 0.0454946791693537 1.0 0.1607263177048751 16 Q93050,P00846 2 +Extracellular structure 0.7024098934876459 1.9679374228650983 0.049075238265853 1.0 0.1657226636855376 9 Q5KU26,Q9Y2T2,P55081,Q92791 4 +ABCB subfamily 0.875996764092906 1.933685297549038 0.0531518326071258 1.0 0.1738799260782456 4 Q03519,P08183 2 +mRNA splicing factor 0.4184429138025115 1.9050501449006736 0.0567735531191557 1.0 0.1786749954968367 60 P62995,Q96PK6,Q13242,Q9BWF3,P35637,Q8WXF1,P98179,O75525,Q8IWZ8,Q96PU8,O75934,P38159,Q07955,P23246,Q07666,Q15233,Q8IY67,Q92804,Q16629,Q14011,Q8WWY3,O75494,Q01844 23 +Tubulin 0.7725178511843972 1.7846219961867034 0.074322651093285 1.0 0.2079152644508354 5 Q9BVA1,P68371,P07437 3 +Oxidase 0.5319662884769752 1.781609129248908 0.0748129946551841 1.0 0.2081818440594157 19 O43169,O15260,O15254,Q15067,Q15800 5 +V-type ATPase 0.6797189875997914 1.7701838509579355 0.076696518644554 1.0 0.2104129318400249 8 Q93050 1 +Heterotrimeric G-protein 0.6755440794846832 1.7498756265591409 0.0801397772773238 1.0 0.2156358127200502 8 Q14344,Q9UBI6,P09471,Q8NHH9 4 +mRNA processing factor 0.3792623144169284 1.6750623768492077 0.0939219937564366 1.0 0.2355939000646542 75 P62995,Q96PK6,Q13242,Q9BWF3,P35637,Q8WXF1,P98179,O75525,Q8IWZ8,Q96PU8,O75934,P38159,O95104,Q07955,P23246,Q07666,Q15233,Q8IY67,Q92804,Q16629,Q14011,Q96SI9,Q8WWY3,O75494,Q01844,Q16531 26 +SLC25 family of mitochondrial transporters 0.5161081460542108 1.625385185086888 0.1040805106090614 1.0 0.2479235156903271 18 Q70HW3,Q9BQT8,O43772 3 +RSK family 0.973915878708837 1.6032313043097166 0.1088835965673296 1.0 0.2544165623623431 2 Q15418 1 +RSK subfamily 0.973915878708837 1.6032313043097166 0.1088835965673296 1.0 0.2544165623623431 2 Q15418 1 +DNA helicase 0.5827687888285207 1.5786506313956206 0.1144162143947988 1.0 0.2609791862743749 11 Q14566,P33991 2 +Metalloprotease 0.451619519577615 1.577761270637954 0.1146204643755341 1.0 0.2611455940927119 38 Q7Z2K6,Q8IYS1,O15372,O43847,P22695,O75844,P53582,P02786,Q5JRX3,P55786,P42892,Q9UIQ6 12 +Methyltransferase 0.5641920512814713 1.5632186569602238 0.1180011732709651 1.0 0.2657294083076571 12 P21964,Q96FX7 2 +Serine protease 0.4595531416637463 1.553404580286606 0.1203265093516166 1.0 0.2692119539936619 27 Q92945,Q9HB40,Q96I24,P42785,Q9H3G5,P10619,O14773 7 +Phosphatase inhibitor 0.6183899045936577 1.3984143968405542 0.1619886623531488 1.0 0.3205924869854855 7 P55209,Q01105 2 +AGC group 0.5555913693274626 1.316351044493892 0.1880562456900403 1.0 0.3565718519327838 10 Q15418 1 +Growth factor 0.6314037734396163 1.3040558679733487 0.1922145344985033 1.0 0.3605849119643562 6 Q96PC5 1 +SNARE protein 0.5094298453429226 1.2423847167319948 0.2140946517688575 1.0 0.3843269515959004 12 O95249,Q86Y82,Q9P2W9 3 +Methyl-lysine/arginine binding protein 0.6432121481828146 1.224430848466458 0.2207897380299459 1.0 0.3912152663749563 5 P45973,Q16637,Q13185 3 +F-type ATPase 0.5418275100013872 1.083720242777459 0.2784888574894022 1.0 0.4532850552753036 8 P00846 1 +Esterase 0.512080877100589 1.0797025839376422 0.2802746429023171 1.0 0.4551558700066967 10 Q9UMR5,P50897 2 +CDK family 0.5816164996270312 1.0749074808292816 0.2824161523852044 1.0 0.4559080011003655 6 Q14004,P06493,P11802,P21127 4 +Phosphatase modulator 0.5013781788386129 1.0214529401143444 0.307039894290257 1.0 0.4817458558088004 10 P55209,Q01105 2 +Glycosyltransferase 0.4338027219432745 0.9727265651950846 0.3306892185522185 1.0 0.5051773085256241 15 P46977,Q10472,Q86SF2,Q8NAT1,Q8N128,Q9BT22,Q8TCJ2,P04843 8 +DNA glycosylase 0.8095859145744979 0.9582437627991984 0.3379398543215397 1.0 0.5103738574377695 2 P78549 1 +Glycosylase 0.8095859145744979 0.9582437627991984 0.3379398543215397 1.0 0.5103738574377695 2 P78549 1 +Reader 0.4606970317578696 0.9545808123864172 0.3397897242249441 1.0 0.512621001693652 12 P25440,P45973,Q16637,Q13185 4 +SLC30 zinc transporter family 0.8069775024454031 0.948301971136246 0.3429757477006947 1.0 0.5146930786543783 2 Q8TAD4 1 +Extracellular matrix glycoprotein 0.6125000030480825 0.8627178251590677 0.3882926294206765 1.0 0.5549227933656831 4 Q9Y2T2 1 +Guanyl-nucleotide exchange factor 0.5548258227201194 0.8399346530502467 0.4009450267523227 1.0 0.5683104741939886 5 Q14C86 1 +Translation initiation factor 0.3888195003868747 0.7803476122008577 0.4351862948732805 1.0 0.5969555451744517 19 O75153 1 +Acyltransferase 0.4403425847650107 0.7726140118431445 0.4397508495175561 1.0 0.601039211534574 11 P35610,P53609,Q8NF37,P49354 4 +P-type ATPases 0.5150017675303471 0.7717219992544222 0.4402790982014093 1.0 0.601039211534574 6 P35670 1 +Transporter 0.3878620518651655 0.716077911703703 0.4739432418545339 1.0 0.6297081550091302 191 Q9H2V7,Q9HD45,P08195,O95721,O43772,Q93050,Q6NT16,Q8TAD4,Q15043,O15439,P25705,Q8IXU6,P55735,P00846,Q9P2W9,Q99567,O60645,Q15070,Q7Z3B4,Q9UI14,Q9Y584,Q99805,Q8TB61,Q9Y487,O95249,Q03519,Q96QD8,P56962,Q92973,P08183,Q08379,P53985,Q6N075,Q70HW3,Q86Y82,Q9Y5K8,P41440,Q99808,P30825,O75027,Q9H2J7,P57740,Q9UPT5,Q8NFH4,P52292,Q8NEW0,P16615,Q92572,Q9Y6C9,P35670,Q8N1F7,Q99523,Q9P253,Q96A65,O96008,Q12769,Q9BQT8,Q96ES6,Q9Y6M7,Q9UBX3 60 +CAMK group 0.5737053873029968 0.7099649406210155 0.47772587749263 1.0 0.6313599802876021 4 O14936,Q14012 2 +Nucleotide phosphatase 0.4555159094835878 0.7024127429476373 0.4824218006518759 1.0 0.6341949514187583 9 Q8IWA4,O43681 2 +Other group 0.4250331045277506 0.6877587974760758 0.4916046865527845 1.0 0.6411814567563858 11 Q96GD4,O14976 2 +Oxidoreductase 0.331618630520141 0.6407180450017221 0.5217058880044263 1.0 0.6663075810204506 117 O95831,Q9UDW1,O94788,O43169,P03915,P30837,O15254,O15260,Q15800,Q96CU9,Q13423,P00403,Q8N0U8,Q15392,Q8N4Q0,Q16850 16 +Protease 0.3187947509805897 0.6007480460779981 0.5480078126933998 1.0 0.68299106648989 105 P42785,P02786,Q96RU2,Q8IYS1,P42892,Q9HB40,Q96AE4,O43847,Q13510,P22695,O75844,P55786,Q9UIQ6,Q96I24,O15372,Q8NHP8,Q9H3G5,Q7Z2K6,O14773,Q92945,P61978,Q9Y6M1,P53582,Q5JRX3,Q96K76,P10619 26 +DMPK family 0.7101402021519345 0.5973093877389558 0.5503008379241905 1.0 0.6845205544910662 2 Q13464 1 +ROCK subfamily 0.7101402021519345 0.5973093877389558 0.5503008379241905 1.0 0.6845205544910662 2 Q13464 1 +Translation factor 0.3393369731502225 0.5965042528761932 0.5508384136034283 1.0 0.6847610029107618 25 O75153 1 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.5416516172874071 0.5886269575158654 0.5561115461024448 1.0 0.6874492636406232 4 Q9BQT8 1 +Tight junction 0.6904761904761691 0.5692459642701957 0.5691892316629656 1.0 0.6915298192167566 3 Q9UDY2,Q16625 2 +Cell-cell junction 0.6904761904761691 0.5692459642701957 0.5691892316629656 1.0 0.6915298192167566 3 Q9UDY2,Q16625 2 +Lyase 0.3613036335064276 0.5685921518312368 0.569632952095537 1.0 0.6915298192167566 18 P53701,P22830,P61457,O96005,P32929 5 +Chromodomain 0.6607958251793769 0.4778012462098691 0.6327916740888238 1.0 0.7245956475317619 3 P45973,Q13185 2 +PKC alpha subfamily 0.6726442777958896 0.4755133709580067 0.6344211051849893 1.0 0.725289250612519 2 P05771 1 +Lipid kinase 0.6370402058577476 0.4089028622570428 0.682610948435517 1.0 0.7536338373764331 3 Q8TBX8 1 +Aspartic protease 0.648190414085422 0.4021780995479433 0.6875529586385931 1.0 0.756638667278568 2 Q5TDH0 1 +Helicase 0.318772637884204 0.3874718305378806 0.69840693535355 1.0 0.7615851943082298 22 Q14566,P33991 2 +Dehydrogenase 0.287283759538517 0.3744075048350451 0.7081011602752274 1.0 0.7666920020617459 58 O95831,O94788,P30837,Q96CU9,Q8N4Q0 5 +Hydrolase 0.2882280202321655 0.3185741388362563 0.750049466630526 1.0 0.7857197783940861 97 Q969T7,Q8IWA4,O43865,P16278,P06865,P10253,Q8NCC3,P50897,Q9UMR5,P00813,Q9NPH0,O43924,P78549,P11117 14 +Bromodomain 0.4023507714563489 0.308556673976207 0.7576587827428307 1.0 0.7878826046037183 6 P25440 1 +TK group 0.449265905383359 0.2818917001095697 0.7780265539249982 1.0 0.8018107853662287 4 Q15375,Q13308,P07948 3 +Protein arginine methyltransferase 0.4486133768352253 0.2800367723182782 0.7794492928483141 1.0 0.8028610271751925 4 Q86X55,O60678,Q99873 3 +G-protein modulator 0.2929193805774344 0.2520412064200685 0.8010092135419562 1.0 0.8187088004804476 27 Q14C86,Q96F07,P53367,P53365,Q9H6Z4,Q8TEU7,Q6WCQ1,Q9H0H5,O14530,Q9H223 10 +Cytokine 0.5855885229866246 0.2417132108545854 0.8090023922772396 1.0 0.8251824401227844 2 Q13123 1 +Reductase 0.2984627007723562 0.1869186408959644 0.8517244234590651 1.0 0.8669804904094578 17 Q15392 1 +Phosphatase 0.2683662951093966 0.1018896257987462 0.918844284519764 1.0 0.9305403675711866 27 Q9NPH0,Q8IWA4,P11117 3 +PKC family 0.452945364066878 0.0583106845012545 0.953501156996298 1.0 0.9626973610485466 3 P05771 1 +SLC56 Sideroflexins 0.4297358982719226 0.0401878745175675 0.967943344554874 1.0 0.9762876837320712 2 Q96NB2 1 +Translation elongation factor 0.304730831973902 0.0179062815618088 0.9857136178566877 1.0 0.9921985758689028 4 Q53EL6,P43897,P29692 3 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..adcc38ade903cf1b8d61d2ffd18197638e673d24 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome non-ATPase regulatory subunit 9", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S16, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3'-5' exoribonuclease 1", "3-Ketosteroid receptors", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L13, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L16, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L23, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L41, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "39S ribosomal protein S18a, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "5'-nucleotidase domain-containing protein 3", "5-formyltetrahydrofolate cyclo-ligase", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AK3 subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-1 complex subunit sigma-2", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit a", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 10, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "ATR subfamily", "AUR family", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 2/3 complex subunit 5", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-CoA-binding domain-containing protein 5", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine deaminase", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose 1-epimerase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Antigen peptide transporter 2", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Arfaptin-2", "Arginase-2, mitochondrial", "Armadillo repeat protein deleted in velo-cardio-facial syndrome", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "Aurora kinase b", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breakpoint cluster region protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK1 family", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 2", "CCR4-NOT transcription complex subunit 7", "CD166 antigen", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CRK7 subfamily", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcineurin-binding protein cabin-1", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium/calmodulin-dependent protein kinase type 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbonyl reductase family member 4", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Chaperone", "Chaperonin", "Charged multivesicular body protein 6", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "ClC-7/CLCN7 subfamily", "Class I transporters", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Copper-transporting ATPase 2", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Coronin-7", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cu+-ATPases", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 11b", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 13", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-g-associated kinase", "Cystathionine gamma-lyase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase alpha subunit B", "DNA polymerase epsilon subunit 2", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA repair protein complementing XP-C cells", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Derlin-2", "Desmocollin-3", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Disks large homolog 1", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 2", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-3", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "Dystonin", "Dystroglycan", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase XIAP", "E3 ubiquitin-protein ligase ZNF598", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELMO domain-containing protein 2", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Endodeoxyribonuclease", "Endonuclease III-like protein 1", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelial protein C receptor", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Ephrin-B1", "Epidermal growth factor receptor substrate 15", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Erythrocyte band 7 integral membrane protein", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2 subunit 3", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 4", "Exocyst complex component 6", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Flavin reductase (NADPH)", "Folate transporter 1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GC-rich sequence DNA-binding factor 2", "GDP-L-fucose synthase", "GMP synthase [glutamine-hydrolyzing]", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTP-binding protein 2", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "Gap junction-forming innexin (innexin) family", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General vesicular transport factor p115", "Geranylgeranyl transferase type-1 subunit beta", "Geranylgeranyl transferase type-2 subunit alpha", "Glia maturation factor beta", "Glucocorticoid receptor", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycogen synthase kinase-3 beta", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgi pH regulator family", "Golgi ph regulator b", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Gtp:amp phosphotransferase ak3, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein G(o) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-11", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Hepatoma-derived growth factor-related protein 3", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone deacetylase complex subunit SAP30", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase NSD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Huntingtin-interacting protein 1", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin superfamily cell adhesion molecule", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol monophosphatase 3", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF18A", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF3A", "Kinetochore protein NDC80 homolog", "Kinetochore protein Nuf2", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit beta-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligand-dependent corepressor", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lipoma-preferred partner", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Long-chain-fatty-acid--CoA ligase 6", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAGUK p55 subfamily member 7", "MAP7 domain-containing protein 1", "MAPK family", "MCU family", "MFS-type transporter SLC18B1", "MHC class II regulatory factor RFX1", "MIF4G domain-containing protein", "MMS19 nucleotide excision repair protein homolog", "MST subfamily", "Magnesium transporter protein 1", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mediator of RNA polymerase II transcription subunit 14", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-bound signaling molecule", "Metal-response element-binding transcription factor 2", "Metallo-beta-lactamase domain-containing protein 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methionine aminopeptidase 1", "Methionine--tRNA ligase, mitochondrial", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Microfibrillar-associated protein 1", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1A", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial import inner membrane translocase subunit Tim22", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 3", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mortality factor 4-like protein 2", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 4", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 2", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "N-acetyl-D-glucosamine kinase", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 5", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurofibromin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Neutral amino acid transporter subfamily", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-14", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Non-structural maintenance of chromosomes element 3 homolog", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear envelope pore membrane protein POM 121C", "Nuclear factor NF-kappa-B p100 subunit", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor", "Nuclear receptor coactivator 5", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Origin recognition complex subunit 3", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PAKB subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PIN2/TERF1-interacting telomerase inhibitor 1", "PITSLRE subfamily", "PKA family", "PKC alpha subfamily", "PKC delta subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pannexin-1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP1A", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Peptidyl-prolyl cis-trans isomerase-like 3", "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal NADH pyrophosphatase NUDT12", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 3-kinase regulatory subunit beta", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylase b kinase regulatory subunit beta", "Phosphorylated adapter RNA export protein", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Prenylated Rab acceptor protein 1", "Presequence protease, mitochondrial", "Primase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable asparagine--tRNA ligase, mitochondrial", "Probable cysteine--tRNA ligase, mitochondrial", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable helicase with zinc finger domain", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Proteasome inhibitor PI31 subunit", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FAM177A1", "Protein FAM89A", "Protein FRG1", "Protein LSM14 homolog B", "Protein Mpv17", "Protein NDRG3", "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SEC13 homolog", "Protein SET", "Protein SYS1 homolog", "Protein Wiz", "Protein XRP2", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein kinase c alpha type", "Protein kinase c beta type", "Protein kinase c delta type", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1F", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein spinster homolog 1", "Protein strawberry notch homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24C", "Protein transport protein Sec24D", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pseudouridine-5'-phosphatase", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RIO family", "RIO2 subfamily", "RIPK family", "RNA 3'-terminal phosphate cyclase", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding motif protein, X-linked-like-1", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with multiple splicing", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab proteins geranylgeranyltransferase component A 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Rap guanine nucleotide exchange factor 6", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein R-Ras2", "Ras-related protein Ral-A", "Ras-related protein Ral-B", "Ras-related protein Rap-2b", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Rel homology transcription factor", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal dehydrogenase 2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoblastoma-associated protein", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-associated protein kinase 2", "Rho-related GTP-binding protein RhoG", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal RNA-processing protein 7 homolog A", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "Ribosome-recycling factor, mitochondrial", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "S1 RNA-binding domain-containing protein 1", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC18 family of vesicular amine transporters", "SLC19 family of vitamin transporters", "SLC2 family of hexose and sugar alcohol transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC30 zinc transporter family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC38 family of sodium-dependent neutral amino acid transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC5 family of sodium-dependent glucose transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC6 neurotransmitter transporter family", "SLC61 Molybdate transporter family", "SLC63 Sphingosine-phosphate transporters", "SLC7 family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRC family", "SRPK family", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "Sarcolemmal membrane-associated protein", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Sedoheptulokinase", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-6", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase atr", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase pak 4", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase rio2", "Serine/threonine-protein kinase tousled-like 2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase wnk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 6 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters", "Sodium-coupled neutral amino acid transporter 2", "Sodium-dependent HCO3- transporters", "Sodium-dependent multivitamin transporter", "Sodium-dependent neutral amino acid transporter B(0)AT2", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 12 member 7", "Solute carrier family 2, facilitated glucose transporter member 1", "Solute carrier family 35 member F2", "Sorbitol dehydrogenase", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Synaptosomal-associated protein 23", "Synaptosomal-associated protein 29", "Syntaxin-12", "Syntaxin-17", "Syntaxin-18", "Syntaxin-3", "Syntaxin-4", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "System A-like transporters", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TLK family", "TOPK family", "TP53-binding protein 1", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Testin", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1B", "Trafficking protein particle complex subunit 4", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription factor 20", "Transcription initiation factor IIA subunit 1", "Transcription initiation factor IIE subunit beta", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation initiation factor IF-2, mitochondrial", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 4", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Trophoblast glycoprotein", "Tropomodulin-1", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-3 chain", "Tubulin beta-4B chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Type II PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "Tyrosine-protein kinase lyn", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 36", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 5", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like modifier-activating enzyme ATG7", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Unconventional myosin-Va", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 26B", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 45", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuolar protein sorting-associated protein 52 homolog", "Vacuolar protein sorting-associated protein 72 homolog", "Vacuole membrane protein 1", "Very long-chain acyl-CoA synthetase", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WASH complex subunit 5", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "WNK family", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YEATS domain-containing protein 4", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 277", "Zinc finger protein 281", "Zinc finger protein 622", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zinc transporter 5", "Zinc transporter 7", "Zinc transporter ZIP14", "Zyxin", "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALYREF", "ANAPC1", "ANO6", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "ARCN1", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG7", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATXN2L", "AUP1", "AURKB", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCAT2", "BCKDK", "BCLAF1", "BCR", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRD2", "BRD4", "BRIX1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CAB39", "CABIN1", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CBR4", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC37", "CDC42", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKN2AIP", "CEBPZ", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHERP", "CHM", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT7", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCPS", "DCTN1", "DCTN2", "DDAH2", "DDB1", "DDI2", "DDOST", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLG1", "DLGAP5", "DLST", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "EPHA7", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAM177A1", "FAM89A", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP1A", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCFC2", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS2", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPDA1", "GNS", "GOLGA2", "GOSR1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GTF2A1", "GTF2E2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GUF1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LCOR", "LDHA", "LDHB", "LETM1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPP", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM6", "LYN", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARS2", "MAT2A", "MBLAC2", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "METAP1", "METTL1", "MFAP1", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF4GD", "MIPEP", "MMS19", "MORF4L1", "MORF4L2", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL38", "MRPL39", "MRPL41", "MRPL44", "MRPL47", "MRPL49", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NARS2", "NBN", "NCAPD2", "NCBP1", "NCL", "NCOA5", "ND5", "NDC80", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NDUFS8", "NEDD4L", "NEK9", "NF1", "NFKB2", "NHP2", "NISCH", "NKRF", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NR3C1", "NRBP1", "NRDC", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OLA1", "OPA1", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAIP1", "PAK2", "PAK4", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDHX", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGGT1B", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PINX1", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPT1", "POGZ", "POLA2", "POLDIP3", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PPA1", "PPA2", "PPAT", "PPIL1", "PPIL3", "PPM1F", "PPM1G", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKACA", "PRKAG1", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSMF1", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPRF", "PUDP", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB3GAP2", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAPGEF6", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBMX", "RBMXL1", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RNASEH2A", "RNH1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RTCA", "S100A11", "S100A13", "SAE1", "SAP18", "SAP30", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT2", "SHPK", "SIN3A", "SIRT1", "SKP1", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMN1*", "SNAP23", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPNS1", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TAP2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDRKH", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIMM22", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMOD1", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM40", "TOP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRMT61A", "TROVE2", "TRUB1", "TSFM", "TSG101", "TST", "TSTA3", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UCK2", "UGGT1", "UNC119B", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP19", "USP28", "USP36", "USP39", "USP47", "USP5", "USP7", "UTP11", "UTP14A", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS52", "VPS72", "VRK1", "VRK3", "WARS", "WASHC5", "WDHD1", "WDR1", "WDR33", "WDR82", "WIZ", "WNK1", "XAB2", "XIAP", "XPC", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS4", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF207", "ZNF277", "ZNF281", "ZNF598", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC4", "ACOX1", "ACOX3", "ACP2", "ACP6", "ADA", "AHCYL1", "AIFM1", "ALDH1A2", "ALDH1B1", "ALG1", "AP3M1", "AP3S1", "ARFIP1", "ARFIP2", "ASAH1", "ASNA1", "ATL2", "ATP2A2", "ATP5A1", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATP7B", "AURKB", "BAIAP2", "BCAS2", "BRD2", "CALU", "CAMK1", "CARM1", "CASK", "CBX3", "CBX5", "CCAR2", "CDK1", "CDK11B", "CDK13", "CDK4", "CETN2", "CIRBP", "CLPTM1", "CLUH", "COLEC12", "COMT", "COPS8", "COX2", "CPVL", "CTH", "CTSA", "CYB5B", "CYB5D2", "CYFIP2", "CYP51A1", "DDB1", "DDI2", "DHCR24", "ECE1", "EEF1D", "EHD4", "EIF3H", "EPHA7", "ERMP1", "EWSR1", "EXOC3", "EXOC4", "EXOC7", "FAM177A1", "FAM89A", "FECH", "FNTA", "FOXRED1", "FUBP1", "FUBP3", "FUS", "GAA", "GAK", "GALNT1", "GALNT7", "GAPVD1", "GLB1", "GNA13", "GNAO1", "GNG12", "GOLGA2", "GOSR1", "HCCS", "HDGFL2", "HEXA", "HNRNPK", "IGF2BP2", "IK", "KHDRBS1", "KHDRBS3", "KHSRP", "KPNA2", "LNPEP", "LPCAT1", "LYN", "M6PR", "MCM4", "MCM6", "METAP1", "MFAP1", "MFN1", "MFSD3", "MFSD5", "MIA2", "MICU1", "MICU2", "MPRIP", "MPV17", "MPV17L2", "MSMO1", "MTCH2", "MYL6", "NAP1L1", "ND5", "NNT", "NONO", "NPEPPS", "NRDC", "NT5C3B", "NTHL1", "NUCB1", "NUCB2", "NUP107", "NUP160", "NUP37", "NUP54", "NUP88", "NUP93", "OCLN", "OXA1L", "P3H4", "PCBD1", "PDCD4", "PDE6D", "PEX14", "PGGT1B", "PGRMC1", "PGRMC2", "PIP4K2C", "PITRM1", "PLA2G15", "PLBD2", "PM20D2", "POMGNT2", "PPT1", "PPT2", "PRCP", "PRKCB", "PRMT1", "PRMT3", "PRPF31", "PSPC1", "PTK7", "PXMP2", "QKI", "RABAC1", "RACGAP1", "RANBP3", "RAPGEF6", "RAVER1", "RBM14", "RBM3", "RBM4", "RBMX", "RCN2", "ROCK1", "RPN1", "RPS6KA1", "SCAF4", "SCARB1", "SCARB2", "SCPEP1", "SEC13", "SET", "SFPQ", "SFXN2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A20", "SLC25A21", "SLC25A26", "SLC29A1", "SLC30A5", "SLC30A7", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC6A15", "SLC7A1", "SMN1*", "SNAP29", "SOAT1", "SORT1", "SPNS1", "SRSF1", "SRSF10", "SRSF7", "SRSF9", "SSR1", "STRBP", "STT3A", "STT3B", "STX12", "STX17", "STX18", "SUGP1", "SURF4", "SYNJ2BP", "TAF15", "TAP2", "TFRC", "TIMM22", "TJP2", "TM9SF2", "TM9SF3", "TNPO1", "TOMM40", "TPP1", "TRA2B", "TRMT61A", "TSFM", "TUBB", "TUBB2B", "TUBB4B", "TXNDC9", "UNC119B", "UQCR10", "UQCRC2", "USP28", "USP47", "VKORC1L1", "VMP1", "VPS18", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2c9a89814544d67cab453c74790749979179bf3 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2f596f9e0db0d81fa0fce3e22b0dafebc4d01c37 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6bce13d043d1c384e58f1842447dad694dd87fc35e940b5aa602c19fa0138ce9 +size 135905 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..4efa69e0d8c7604d94d1da7c20c616ce761fb95b --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:01758257cf36e224f38e1425129a1a554cbd5c9ac9e4a7dd77fbe0073c66aaed +size 67598 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..53769e6783dae2e1e796e832567f84a137207074 --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 767.0 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2d5b5fb7d61a4c011ed5537f67f2a80505b285f2 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..12a11e0538f94080909718775972b1b3aac8665a --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tclin 0.3136449303547713 0.7108540607323606 0.4771746761605009 0.9252817897536376 1.0 88 P21964,P00813,O96000,O43924,P07437,O60658,Q9BVA1,O43674,P68371,O43676,P00374,P62942,P03915,P10253,P06280,P49721,P28074,P48735,Q99720 19 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ae39755e938aa7b7fd4897679e428171234ae5ab --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C3orf58", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG4", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM89A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", 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+++ b/protein_atlas_biological_process/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Ion transport 25 63 2.9832197486777465 0.002852331211637 19.82766990291262 54.68446601941748 1.177785596906995 0.303722365376275 8.99659651977233 7.41832233515522 1.8666057057567336 0.3607289685223158 0.0640152768143439 0.0019958362193078 0.0094209892463906 0.0007044328441734 0.0001489931323581 +Translocation 21 51 2.927387306203467 0.0034182291319921 12.434466019417476 47.86165048543689 1.1297087783550883 0.3515144245437065 6.687771513864753 3.601211391947168 1.550426642680832 0.3811939235350816 0.0007460176661032 0.0050226976439289 0.0051349844611066 6.327964276109687e-05 5.986234223342348e-08 +Cholesterol biosynthesis 3 12 2.212123980692088 0.026958099580888 4.478155339805825 14.449029126213592 1.241205081084055 0.2669045154832569 1.9237928998467095 1.7749125587996368 0.9260618360685376 0.2641298712278396 0.0312118869909902 0.0858288536093336 0.0135177788357734 0.0009343298569185 0.0118045746321095 +Vision 3 7 2.0826549155873555 0.0372826897173801 2.3470873786407767 5.992718446601942 1.08525596348634 0.2199144433248849 1.3876767838522928 1.281854462283163 1.178949427510656 0.2385050933787637 0.0517230705067455 0.0060764540616979 0.0228657680446322 0.0211121130334516 0.0306674579519183 +Cholesterol metabolism 5 20 2.0340644815948874 0.041945094524592 7.111650485436893 23.79854368932039 1.169709264926864 0.2871268807807383 2.8890755390042298 2.7173834172675666 1.205315163774447 0.3061468445376054 0.0282335164695639 0.1916891885455893 0.0668951919761703 0.0042163593313455 0.0205399046658008 +Sensory transduction 3 8 2.031676437133161 0.042186422845208 2.3907766990291264 6.065533980582524 1.0901502088613606 0.2182341455376904 1.4245463862041683 1.4083924790550797 1.1790733646497054 0.2382326050755758 0.0715416679946375 0.0086801325315587 0.0321664764057317 0.0341659855040389 0.0550493127109652 +Sterol biosynthesis 3 13 1.9815266593679173 0.0475322427205791 4.970873786407767 15.854368932038836 1.2489526119817105 0.2730082640054638 2.2746228138386324 2.237837752303934 0.9571049414552286 0.2704007779320353 0.0409762817664239 0.0987043131013681 0.0179304062363867 0.0016666756698247 0.0198699646710478 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..81741c07695f8cf93ac52fa3028e506284cdc02a --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 168, + "title": "Average number of proteins per term", + "value": 29.648809523809526 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5c192f9d11beef5fef58984a562943fdf6805e23 --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1809fd856473f3dad49bee3b7248fe1232277796 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,49 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Ion transport 0.5021627304671993 2.9832197486777465 0.002852331211637 0.3811400924544108 0.1755894768204346 63 P25705,Q93050,Q15043,Q8TAD4,P00846,Q8TDW0,P45880,P51790,P21796,Q9BPX6,Q9Y277,Q15904,Q9Y487,Q96QD8,Q6N075,Q9Y5K8,O75964,Q9H2J7,P16615,Q9C0H2,P35670,Q6P4Q7,Q9H0H5,Q9H4I9,Q9Y6M7 25 +Translocation 0.5639284939216729 2.927387306203467 0.0034182291319921 0.4374336616058727 0.1755894768204346 51 Q8TD16,Q99595,Q99567,P55735,Q9NS69,Q7Z3B4,Q9Y584,O60830,P12270,Q8N4Q1,O75381,P41208,Q8NFH5,Q9BTX1,O14925,P62072,P57740,Q8NFH4,Q3ZCQ8,Q8N1F7,Q15629 21 +Cholesterol biosynthesis 0.6794026557325644 2.2121239806920876 0.026958099580888 0.9898585735257488 0.2516089294216215 12 Q15392,Q15800,Q16850 3 +Vision 0.763641403432834 2.0826549155873555 0.0372826897173801 0.9983103561518736 0.3075877844833847 7 Q6P4Q7,O43924,P50897 3 +Cholesterol metabolism 0.5608053282341345 2.0340644815948874 0.041945094524592 0.9992525416162732 0.3081443059997802 20 P37268,O15118,Q15392,Q15800,Q16850 5 +Sensory transduction 0.7342351579943598 2.031676437133161 0.042186422845208 0.9992835165845992 0.3081443059997802 8 Q6P4Q7,O43924,P50897 3 +Sterol biosynthesis 0.6180823696612903 1.9815266593679175 0.0475322427205791 0.9997202001114792 0.3243677402455294 13 Q15392,Q15800,Q16850 3 +Sphingolipid metabolism 0.6585508991019906 1.8643415899329627 0.0622737498072147 0.999979639878691 0.3487329989204027 10 P07602,Q06136,Q13510 3 +Sterol metabolism 0.5214217975107269 1.8195427287295871 0.0688286701372076 0.9999937342637834 0.3730069865500283 21 P37268,O15118,Q15392,Q15800,Q16850 5 +Hydrogen ion transport 0.5260428523647233 1.7943035130757243 0.0727647376880391 0.9999969245420096 0.3820148728622055 20 Q93050,O75964,Q9Y487,P00846 4 +Amino-acid transport 0.6730141861290477 1.737550649117865 0.082290022082627 0.9999994573544906 0.3959211385407897 8 P08195,P30825,Q9H2J7,Q15758,Q96QD8 5 +Respiratory chain 0.4741025878043502 1.6998795663784785 0.0891535811781585 0.9999998462602872 0.4160500454980731 32 Q9UDW1,P03915,O43676,Q96CU9,O96000,P00403,Q6DKK2 7 +Immunity 0.3696585748085581 1.5910490831944069 0.1115985300173278 0.9999999976753524 0.4687138260727772 72 P14174,O00584,Q8IV08,Q9NUD5,P12956,Q96PK6,Q03519,Q8N5M9,O43823,P04439,P46379,Q9UQ84,P10321,Q8WXF1,Q96CV9,P23246,Q15233 17 +Steroid metabolism 0.474173419437613 1.5345376596668476 0.1248974358478738 0.999999999815539 0.4995897433914953 22 O15118,Q15392,Q15800,Q16850 4 +Hypusine biosynthesis 0.9530485816759068 1.5206094318221808 0.1283578785108527 0.9999999999051976 0.5000088627994603 2 Q9BU89 1 +Electron transport 0.4259200562533178 1.4685466938758176 0.1419557823845565 0.9999999999932452 0.5299682542356777 45 Q9UDW1,O43169,P03915,O43674,Q9H1E5,P22695,Q96CU9,O96000,P21912,O43676,P00403,Q6DKK2 12 +Cilium biogenesis/degradation 0.4914121897143649 1.4169907974837233 0.1564856180284364 0.9999999999996168 0.5610752467220684 17 O95684,A6NIH7 2 +Nucleotide metabolism 0.5700973617430216 1.2960045966943112 0.1949739012362279 1.0 0.6080979420976445 9 P00813,Q969T7,P22392 3 +Lipid transport 0.4675097360876976 1.2928952513432912 0.1960472901178178 1.0 0.6080979420976445 18 Q9H2V7,O15118,Q99720,Q9Y255 4 +Spermatogenesis 0.4542441085284844 1.284177993217154 0.199079683424824 1.0 0.6080979420976445 20 Q14671,P46379,Q9Y2W6,Q9H0H5,Q08J23 5 +Steroid biosynthesis 0.4475459082799098 1.1933068185658622 0.232749233052413 1.0 0.6741701922897481 19 Q15392,Q15800,Q16850 3 +Porphyrin biosynthesis 0.6150429804092451 1.1010708045524895 0.2708658424417245 1.0 0.7422111017825621 5 P36551,P22830 2 +Symport 0.5300771117772769 1.0873838798400044 0.2768671923338237 1.0 0.7422111017825621 9 Q96QD8,Q9H2J7,P53985 3 +ATP synthesis 0.5419284794139375 1.084229224498939 0.2782631770208392 1.0 0.7422111017825621 8 O75964,P00846 2 +Zinc transport 0.807240704500966 0.9678652157431794 0.3331116883481506 1.0 0.7700941714055755 3 Q15043,Q8TAD4 2 +Purine salvage 0.5656375330098649 0.8863291508629016 0.3754401850377018 1.0 0.7884243885791739 5 Q13126 1 +Glyoxylate bypass 0.7717639387023283 0.816097835310803 0.4144441819161351 1.0 0.8491051531940329 2 P48735 1 +Phagocytosis 0.7090671885192275 0.6291064290071339 0.5292793818220636 1.0 0.934931745991226 3 Q14185,P50570 2 +Calcium transport 0.4194959421941963 0.5851278679203968 0.5584617417599724 1.0 0.934931745991226 10 P16615,Q9H4I9,Q13586,Q9BPX6 4 +Adaptive immunity 0.368459036788392 0.5741814066638061 0.5658450500359644 1.0 0.934931745991226 16 P05771,Q03519,P04439,P10321,Q07021 5 +Sodium transport 0.436253265358448 0.5633784908463646 0.5731771804998123 1.0 0.934931745991226 8 Q96QD8,Q9H2J7 2 +Neurogenesis 0.3276025399626628 0.5447974329853049 0.5858928443915883 1.0 0.934931745991226 45 Q96EK5,Q8WUJ1,Q969G3,P16949,Q9BVA1,Q8N5V2,Q16637,Q16352,P55209,P98172,Q14012,P15531,P48681 13 +Stress response 0.331794470216563 0.5299613065794448 0.5961387585847 1.0 0.934931745991226 27 Q14011,O00459,P51812,Q15418,O95197,P98179 6 +Transcription termination 0.6744115673148044 0.5190696568010489 0.6037121671534267 1.0 0.934931745991226 3 Q9UNY4 1 +Endocytosis 0.3264036582195586 0.4792559227024113 0.6317565748445466 1.0 0.934931745991226 30 P50570,Q14C86,Q07954,P02786,O00291,P15531 6 +Phospholipid metabolism 0.3557317358511578 0.4694090216926237 0.6387773010206104 1.0 0.934931745991226 14 Q96N66,Q9NPH0,Q8NF37 3 +Inflammatory response 0.3663997418899866 0.4220360198354397 0.6729987263925996 1.0 0.9501158490248464 12 Q8IV08 1 +mRNA transport 0.2680003541535734 0.3939513796874198 0.6936169358004753 1.0 0.9551446329055726 66 P12270,Q8N1F7,Q92945,Q8TD16,Q16629,Q96PU8,Q53F19,Q99567,Q8NFH4,P41208,Q8NFH5,Q7Z3B4,Q9Y6M1,Q07955,P22626,Q9BTX1 16 +Innate immunity 0.2937743626487086 0.3765850271915021 0.7064820165392471 1.0 0.9571691836983348 55 P14174,O00584,Q9NUD5,P12956,Q96PK6,P04439,O43823,P10321,Q8WXF1,Q96CV9,P23246,Q15233 12 +Antiport 0.3699082317865977 0.2544177792016114 0.7991728169432926 1.0 1.0 7 P41440 1 +Pyridine nucleotide biosynthesis 0.5800456472122524 0.2296321544607504 0.8183776188153866 1.0 1.0 2 P43490 1 +Myogenesis 0.3309498837194726 0.1250403871941505 0.9004915768734609 1.0 1.0 7 P85037 1 +Antiviral defense 0.2648494144869157 0.1028908603965599 0.918049591548502 1.0 1.0 24 Q13217,Q92841,Q9NUD5,Q53F19,Q13309,Q9BUI4 6 +Methionine biosynthesis 0.4532116074339679 0.05399260781632 0.9569410537604476 1.0 1.0 2 Q9BV57 1 +Autophagy 0.2625930009193875 0.0402183118971554 0.9679190786579042 1.0 1.0 33 Q96GC9,Q7Z3C6,Q9P253,Q9Y6I9,P56962 5 +Cell shape 0.2959264399816743 0.0225952388901237 0.9819731416748264 1.0 1.0 6 P35580 1 +Branched-chain amino acid catabolism 0.3674600586892719 0.021153490661071 0.9831232150467936 1.0 1.0 2 Q6NVY1 1 +One-carbon metabolism 0.2811785063520975 0.0039201957460639 0.9968721443503394 1.0 1.0 9 O43865 1 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..37feb502075ab38c5d14f439713664cc54a955c9 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Biological rhythms", "Biomineralization", "Blood coagulation", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Copper transport", "Cysteine biosynthesis", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Erythrocyte maturation", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Hemostasis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Keratinization", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN4", "ACTR3", "ADA", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8", "AKAP8L", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDOA", "ALDOC", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKLE2", "ANO6", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "API5", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARL8B", "ARMT1", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATR", "ATRX", "AUP1", "AURKB", "BABAM1", "BABAM2", "BAG3", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOD1L1", "BOP1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C1QBP", "CACYBP", "CAD", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CARS2", "CBR4", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC51", "CCDC59", "CCDC86", "CCDC93", "CCNB1", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPF", "CENPV", "CERS1", "CERS2", "CETN2", "CFL1", "CGGBP1", "CHAF1A", "CHAF1B", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "COG6", "COG7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPZ1", "COQ5", "COQ8A", "CORO7", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF16", "DCPS", "DCTN1", "DCTN3", "DCUN1D1", "DCXR", "DDB1", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DEGS1", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPYSL2", "DSC3", "DSG2", "DST", "DTNBP1", "DTYMK", "DUS2", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM162A", "FAM208A", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCFC2", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GHITM", "GINS2", "GINS3", "GINS4", "GM2A", "GMPS", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPI", "GPKOW", "GPR89B", "GRB2", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP3", "GTPBP4", "GUF1", "GYS1", "H2AFX", "HACD3", "HADH", "HADHA", "HADHB", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INTS13", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JUP", "KARS", "KAT7", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "LAMB1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPGAT1", "LPP", "LRP1", "LRPPRC", "LRRC41", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1S", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METTL1", "MFAP1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MIA3", "MICAL3", "MICU1", "MID1", "MIF", "MIF4GD", "MINDY3", "MKI67", "MLEC", "MMS19", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MRE11", "MRGBP", "MRPL41", "MRPL58", "MRPS27", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYCBP", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA15", "NAE1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NFKB2", "NGEF", "NHP2", "NIP7", "NISCH", "NKRF", "NLE1", "NME1", "NME2", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPLOC4", "NPM1", "NR3C1", "NRDE2", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NTHL1", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OGDH", "OGT", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PANK4", "PANX1", "PAPOLA", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK1", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PECR", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHKB", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN1", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLIN3", "PLK1", "PLRG1", "PMF1", "PMVK", "PNKP", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POP1", "PPAT", "PPHLN1", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1R8", "PPP2R1A", "PPP4R2", "PPP5C", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRELID1", "PRIM1", "PRIM2", "PRKAG1", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP2", "RANBP3", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM14", "RBM15", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCOR1", "REEP4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN3", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RTCB", "RTF1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SON", "SORT1", "SPC24", "SPC25", "SPEN", "SPNS1", "SPTLC1", "SPTLC2", "SRCAP", "SREK1", "SRM", "SRPK1", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STK4", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", 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"WDR61", "WDR75", "WTAP", "XAB2", "XIAP", "XPC", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "ZBED4", "ZC3H11A", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZMYM2", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ACP6", "ADA", "ADI1", "AHCYL1", "AKAP8", "ASAH1", "ATG9A", "ATP2A2", "ATP5A1", "ATP5L", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATP7B", "BAG6", "BICD2", "C1QBP", "CAMK1", "CETN2", "CHCHD4", "CIRBP", "CLCN3", "CNNM4", "COX2", "CPOX", "CYB5B", "CYB5D2", "CYP51A1", "DDX17", "DHCR24", "DNAJC3", "DNM2", "DOCK1", "DOHH", "EFNB1", "EXO1", "FDFT1", "FECH", "FGFR1OP", "FOXK1", "FOXRED1", "GAPVD1", "HIBCH", "HIP1", "HLA-A", "HLA-C", "HNRNPA2B1", "IDH2", "IGF2BP2", "INA", "JAGN1", "KDSR", "KHSRP", "KIFBP", "LPCAT1", "LRP1", "LRRC8C", 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a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..96587401a53336b1222bd8876f071f7a17015658 --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Gangliosidosis 2 5 2.178685886673315 0.0293550109138713 2.8567961165048543 4.902912621359223 0.2158556094961241 0.1574800557957235 1.2213224676890235 0.2960767122713962 1.9039254823866087 0.2239345049259472 3.0544610870123085e-05 0.0233225886554715 0.0462079787001647 0.0001306525606321 0.001050644193994 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..be86e65eb9783e184a6d2efffe52c35aa1e7fcec --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 115, + "title": "Average number of proteins per term", + "value": 21.17391304347826 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d6e56c796cbfe70f04894b72631bcf702b706459 --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dea1d63b98cc142a40dee1a16f925419ea227c3c --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,42 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Gangliosidosis 0.8669638455363715 2.178685886673315 0.0293550109138713 0.9674951670438852 0.2596789426996314 5 P07602,P16278 2 +Mucopolysaccharidosis 0.7880010641779347 1.8502674808097848 0.0642750071867366 0.9995191092904884 0.4348015192043947 5 P54802 1 +Primary mitochondrial disease 0.3994548568526858 1.6701771818790103 0.0948843131903589 0.999989505287123 0.6062053342717377 98 Q9Y2R0,O95831,P25705,P03915,P39210,P00846,O43676,Q96CU9,P00403,Q6DKK2,Q8NI60,Q9Y584,Q9BQT8,Q70HW3,Q9UBX3 15 +Neuronal ceroid lipofuscinosis 0.9712981082844084 1.5677216336757611 0.116946110614176 0.999999385490096 0.6411905835944998 3 O75503,P50897 2 +Charcot-Marie-Tooth disease 0.4591839969558927 1.5461226314031078 0.1220749540651187 0.9999996855109818 0.6411905835944998 24 O95831,P54802,P02545,P07196,P39210 5 +Ciliopathy 0.6272526082043948 1.512331840587437 0.1304494648144269 0.9999998955508108 0.6411905835944998 8 O43924 1 +Leber hereditary optic neuropathy 0.9240299967394928 1.4056610636601083 0.1598247941042296 0.9999999979930616 0.6411905835944998 2 P00846 1 +Leigh syndrome 0.5485128655820373 1.3860890267797608 0.1657197206424925 0.9999999991069466 0.6411905835944998 11 P00846 1 +Congenital muscular dystrophy 0.6396153158762259 1.3417672204449096 0.1796714837352078 0.9999999998715904 0.6411905835944998 6 Q8NAT1,O43505,P02545 3 +Hirschsprung disease 0.8956635148353544 1.293494097955156 0.1958402240489174 0.9999999999869872 0.6411905835944998 2 P42892 1 +Limb-girdle muscular dystrophy 0.5669436479726312 1.279603484211924 0.2006846238649196 0.9999999999935048 0.6411905835944998 9 O14979,Q9Y5P6,Q8NAT1,P02545 4 +Joubert syndrome 0.8757163288495535 1.2165663929919852 0.2237692358442342 0.9999999999997766 0.6411905835944998 3 O43924 1 +Gaucher disease 0.875774372350844 1.2151455383156138 0.2243105878242408 0.999999999999794 0.6411905835944998 2 P07602 1 +Amyotrophic lateral sclerosis 0.4885003805338544 1.2033560367895044 0.2288385728110429 0.9999999999998948 0.6411905835944998 13 P35637,P43243,Q96CV9,P50995,Q14203,Q99720 6 +Cataract 0.3948170318624657 1.0359913772787628 0.3002061652669137 1.0 0.6883386012656298 24 Q9H6K4,P08670,Q9NSE4,P48449,Q9UG56,Q15800 6 +Spinocerebellar ataxia 0.5013168444644829 1.0211193440119462 0.3071978993320385 1.0 0.6883386012656298 10 Q8IV08 1 +Congenital disorder of glycosylation 0.4282977882754745 0.9900708049170828 0.3221395121575576 1.0 0.6883386012656298 17 Q2TAA5,Q8N511,P46977,Q15904,P34949,Q8TCJ2 6 +Dystroglycanopathy 0.5653282789622804 0.8849980382549267 0.3761576894153946 1.0 0.7724666836208997 5 Q8NAT1,O43505 2 +Primary microcephaly 0.4684774490898336 0.6739494374239628 0.5003434600457957 1.0 0.937147330022434 7 Q86XL3 1 +Neuropathy 0.325584289498169 0.5640027070329616 0.5727522898454955 1.0 0.9494184247458348 48 P50570,O95831,P54802,P02545,P07196,Q15067,P39210,P00846,Q9NSE4,Q9H4A3,Q96BR5 11 +Emery-Dreifuss muscular dystrophy 0.4854376436369289 0.553005476545166 0.5802596600883603 1.0 0.9494184247458348 5 P02545 1 +Rhizomelic chondrodysplasia punctata 0.6736224323443083 0.4785543450785137 0.6322557041121437 1.0 0.9494184247458348 2 O15228 1 +Zellweger syndrome 0.5108523686629537 0.4779854666141351 0.6326605491623156 1.0 0.9494184247458348 4 O75381,P56589 2 +Peroxisome biogenesis disorder 0.5108523686629537 0.4779854666141351 0.6326605491623156 1.0 0.9494184247458348 4 O75381,P56589 2 +Dystonia 0.4186126030365337 0.4494242162289671 0.6531256654915336 1.0 0.959083996395166 7 Q15043,O75569,P51572 3 +Proto-oncogene 0.3105014342004688 0.3858465447707924 0.6996103217109624 1.0 0.9744126218480236 44 P12270,Q92734,Q92804,P35637,P06753,Q9H6U6,Q16204,Q06136,P46108,Q01105,Q92733,Q03164,Q01844,O96028 14 +Neurodegeneration 0.3165546056992832 0.3809077273637053 0.7032717183772692 1.0 0.9744126218480236 126 P04062,Q8TD16,P02545,Q15043,P39210,Q96CV9,P27544,Q9NQT5,Q96BR5,P35637,Q8IV08,Q14108,P17480,P50897,Q13510,Q8NI60,Q03252,P50995,P50570,O95831,O75503,Q9H4A3,O14773,P54802,P06865,P07196,O00291,Q99720 28 +Intrahepatic cholestasis 0.6224323443103957 0.3310552129618659 0.7406027807303093 1.0 0.9761680809683854 2 Q9UDY2 1 +Microphthalmia 0.4076855021734304 0.3277738949112414 0.7430826267257069 1.0 0.9761680809683854 6 P53701 1 +Lissencephaly 0.3580788508933272 0.2906410842765726 0.7713258350700833 1.0 0.978943897045306 10 P07942,Q8NAT1 2 +Deafness 0.2899001657802705 0.238064475808969 0.8118310868984882 1.0 1.0 47 Q16740,O95831,Q13868,Q13217,Q9NR28,Q15067,Q9NSE4,Q9NWM8,Q9UG56,P68371 10 +Craniosynostosis 0.3850303741101561 0.2067792739308383 0.8361822433373469 1.0 1.0 5 P16435 1 +Ichthyosis 0.3501997372570454 0.2003791363633162 0.8411840753608608 1.0 1.0 8 O95721,Q15738,P51648,Q10567,P04062 5 +FDA approved drug targets 0.2924688779144942 0.1651243380754446 0.8688461169406974 1.0 1.0 120 P21964,P00813,P02786,Q8N0U8,P07437,Q9UNN8,Q16850,P49354,P09525,Q96QD8,P68371,P36404,P16615,Q13423,P20645,P62942,P10253,P23786,P49721,P28074,P48735,Q99720 22 +Cardiomyopathy 0.270769723235146 0.117563000913676 0.9064139225803416 1.0 1.0 23 P02545,P00846 2 +Leukodystrophy 0.2821839123748525 0.1103022369958764 0.9121696832251718 1.0 1.0 17 P07602 1 +Cockayne syndrome 0.4841865014672269 0.0799389066939024 0.9362858457604512 1.0 1.0 2 P18074 1 +Fanconi anemia 0.475383110531459 0.0715799921023728 0.9429361632132368 1.0 1.0 2 Q9BXW9 1 +Parkinsonism 0.2989523613621769 0.0680397815465194 0.945753966547636 1.0 1.0 10 Q15043,P04062 2 +Epilepsy 0.2444332781219269 0.0449255376095889 0.9641666613221722 1.0 1.0 62 O75503,Q14108,Q13813,Q13510,Q03252,P27544,O14773,O14874 8 +Aicardi-Goutieres syndrome 0.3832354859752095 0.014723573452987 0.9882527125001236 1.0 1.0 3 Q9Y3Z3,P55265 2 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..36dec9428350d6095d5840cfd5a2869ed6463302 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Phenylketonuria", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pseudohermaphroditism", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ACAA1", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD3", "ADK", "ADNP", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKR1B1", "ALCAM", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ANAPC1", "ANK3", "ANKLE2", "ANO10", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA7", "AP1B1", "AP1S2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APEX1", "APPL1", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ARPC1B", "ASAH1", "ASCC1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP7B", "ATR", "ATRX", "ATXN10", "AURKB", "B4GAT1", "BAG3", "BANF1", "BAZ1B", "BCAP31", "BCAS3", "BCAT2", "BCKDHA", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRB", "BMS1", "BPTF", "BRAT1", "BRD4", "BUB1B", "C19orf70", "C1QBP", "C3orf58", "CAD", "CALM3", "CALR", "CAMK2G", "CAMLG", "CANX", "CAPN1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCNB1", "CCT5", "CDC16", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CENPF", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD3", "CHD4", "CHD7", "CHD8", "CHM", "CHMP1A", "CISD2", "CIZ1", "CKB", "CKMT1A*", "CLCN7", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT2", "COA3", "COA7", "COG6", "COG7", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COX15", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRK", "CRTAP", "CSDE1", "CSE1L", "CSNK2A2", "CSNK2B", "CSTB", "CTH", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DARS", "DARS2", "DAXX", "DBN1", "DBT", "DCPS", "DCTN1", "DCUN1D1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEGS1", "DEK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIS3", "DKC1", "DLD", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DSC3", "DSG2", "DSP", "DST", "DTNBP1", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFNB1", "EFTUD2", "EHMT1", "EI24", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF2S3", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC8", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "FADS2", "FAF1", "FAM120A", "FAM3C", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSB", "FASN", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTA", "FNTB", "FOXO3", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GCDH", "GCLM", "GDAP1", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI3", "GNAO1", "GNE", "GNPAT", "GNS", "GOLGA5", "GOPC", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPI", "GRB2", "GSK3A", "GSK3B", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2E2", "GTF2I", "GTPBP2", "GTPBP3", "GUF1", "GUSB", "GYS1", "H3-3A*", "H4C1*", "HADH", "HADHA", "HADHB", "HAX1", "HCCS", "HCFC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIP1", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2R", "ILF3", "IMPAD1", "IMPDH2", "INF2", "INTS1", "INTS12", "IPO7", "IRF2BPL", "IRS4", "ITGB1", "ITPA", "IVD", "JAGN1", "JAM3", "JUP", "KARS", "KDM1A", "KDM3B", "KDM5A", "KDSR", "KIF11", "KIF1A", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KMT2A", "KTN1", "L2HGDH", "LAMB1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LGALS3BP", "LIPA", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPP", "LRBA", "LRP1", "LRPPRC", "LSS", "LTA4H", "LYN", "LYRM7", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN2B1", "MAP1A", "MAP1B", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MARS", "MARS2", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MESD", "MFN2", "MGME1", "MICU1", "MID1", "MIF", "MIPEP", "MKI67", "MMAB", "MMADHC", "MOGS", "MORC2", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTHFS", "MTMR2", "MTOR", "MTPAP", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYO5A", "MYO6", "NAA10", "NAA15", "NAGLU", "NAMPT", "NANS", "NARS2", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEK9", "NF1", "NFKB2", "NFU1", "NHLRC2", "NHP2", "NISCH", "NME1", "NME2", "NNT", "NONO", "NOP56", "NPC1", "NPM1", "NR3C1", "NSD2", "NSD3", "NSDHL", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NTHL1", "NUBPL", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "OPTN", "OSGEP", "OTULIN", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PANX1", "PARD3", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDCD4", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDK1", "PDK3", "PDXK", "PEPD", "PEX14", "PEX16", "PEX19", "PEX3", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKB", "PICALM", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIN1", "PINX1", "PISD", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPT1", "POGZ", "POLA1", 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"UBQLN4", "UBR5", "UBTF", "UFSP2", "UGDH", "UGP2", "UMPS", "UPF3B", "UQCC2", "UQCRB", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP9X", "UTP4", "VANGL1", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VKORC1L1", "VPS13D", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VRK1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP2", "WDCP", "WDR1", "WDR11", "WDR36", "WDR5", "WNK1", "XIAP", "XPC", "XPNPEP3", "XPO1", "XRCC5", "XRCC6", "XRN1", "YARS", "YARS2", "YBX1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZCCHC8", "ZMPSTE24", "ZMYM2"], "leading_proteins": ["ACOX1", "ADA", "ADAR", "AIFM1", "ALDH3A2", "ALG11", "ANKLE2", "ANXA11", "ANXA4", "AP1B1", "ARL2", "ASAH1", "ATP2A2", "ATP5A1", "ATP6", "ATP6AP1", "B4GAT1", "BCAP31", "BCAS3", "BCKDK", "BICD2", "CCDC6", "CERS1", "CLN5", "CLPP", "COA3", "COA7", "COMT", "COQ8A", "COX2", "CPT2", "CRK", "CYP51A1", "DCTN1", "DIABLO", "DNAJC3", "DNM2", "ECE1", "ERCC2", "EWSR1", "EXOSC2", "EXOSC3", "FANCD2", "FKBP14", "FKBP1A", "FNTA", 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sha256:46b0057e28ccf8b25db590e6898f0601db1ece3b24f55f144bab8fe0621d9f3a +size 78019 diff --git a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e587f492472c6a72288cf0095ef05dd986f34c96 --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Protease 20 75 2.6236316158912696 0.0086997824683634 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 0.0020889902619198 0.0936030661724457 0.0059078200570518 0.0092937251987308 0.0038866031072789 +Metalloprotease 8 26 2.619278294548224 0.0088116029343523 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 0.0535543299750337 0.2400196775334175 0.0171810218627354 0.0496980479130317 0.0017469853347645 +Carboxypeptidase 4 6 2.59211812132501 0.0095387014453178 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 5.4147040107159925e-05 0.0021914548918381 0.0003390497899834 1.859291904643278e-05 0.0005240184523993 +Translocase 7 23 2.478672180185625 0.0131872445749781 8.031553398058252 23.23543689320388 0.8266305625937611 0.3429767730570308 3.903132239147793 3.2553774114037415 1.2917497354360188 0.3272657999875639 0.001836665186357 1.0 0.0024049294720084 8.375063084086791e-05 0.002226291457822 +Receptor 13 39 1.9901254940504096 0.0465771130773888 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0312704883976492 0.1129146346736405 0.2093493899638266 0.0777064454818162 0.1557458076208086 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..4ce1c6fe9d9acc51995f443fa9078dc44ea9c5c6 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 97, + "title": "Average number of proteins per term", + "value": 37.7319587628866 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8feb336e81777f82129fa773fb83037cea2f456d --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8e58c2664ec3033f0959a084906e3bae1bc2e1a2 --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,23 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protease 0.4591391421007663 2.6236316158912696 0.0086997824683634 0.5715456627269331 0.0925254040195834 75 Q16740,P09960,P42785,Q96RU2,P42892,Q9HB40,O43847,O75844,P28072,P55786,Q9UIQ6,O75976,Q9H3G5,Q7Z2K6,O14773,Q99436,Q5JRX3,P28074,Q96K76,P10619 20 +Metalloprotease 0.6006157209620465 2.6192782945482236 0.0088116029343523 0.5762084212652514 0.0925254040195834 26 Q7Z2K6,P09960,O75976,O75844,Q5JRX3,P55786,P42892,Q9UIQ6 8 +Carboxypeptidase 0.9267423980861944 2.59211812132501 0.0095387014453178 0.6053259977106875 0.0925254040195834 6 P10619,P42785,Q9HB40,Q9H3G5 4 +Translocase 0.5948300962937578 2.478672180185625 0.0131872445749781 0.7240876210045124 0.1084591146982033 23 P35670,Q03519,O15439,Q13423,Q9HD20,P08183,P00403 7 +Monooxygenase 0.902671780726763 2.038924750864081 0.0414575382568944 0.983544861435222 0.2010690605459381 4 Q16850,Q9BU89 2 +Receptor 0.4975264069738041 1.9901254940504096 0.0465771130773888 0.9902118508838256 0.2151419032622248 39 Q5KU26,Q9UNN8,P20645,P55899,Q14108,P30825,Q07954,Q8WTV0,P11717,Q9NS69,O15118,Q99720,O15031 13 +Glycosidase 0.5355139725626155 1.7560702533339845 0.0790764135996777 0.9996613985418716 0.3068164847667498 18 P54802,P16278,P06865,P06280,P10253,P04066,Q9BTY2,O60502,P78549,P04062 10 +Guanine-nucleotide releasing factor 0.5439143315949462 1.7236423910885807 0.0847724208443976 0.9998145091218734 0.3103078970872003 16 P80303,Q02818,Q8TEU7,Q14C86 4 +Porin 0.8211602866277437 1.7142706933709595 0.0864790228636307 0.999845226403284 0.3103078970872003 4 P45880 1 +Serine protease 0.6648438837682104 1.6976522574171076 0.0895734135921815 0.9998886325278852 0.3103078970872003 8 Q16740,O14773 2 +Transducer 0.59174540013094 1.51134749732029 0.1306999384810891 0.9999987426334432 0.3961841885208016 10 Q14344,Q9UBI6,P02786,P09471 4 +Threonine protease 0.9207436399217186 1.3819685948573497 0.1669813441805936 0.99999997988553 0.437761902311286 3 Q99436,P28072 2 +Aminopeptidase 0.5301370591646659 1.3643315415768498 0.1724632430980492 0.9999999893984974 0.4402351205397574 12 P55786 1 +Prenyltransferase 0.6447665919768957 0.9929309395278252 0.320743610798428 1.0 0.5869625076366625 4 P49354 1 +Exonuclease 0.3543017943212142 0.6018689498334813 0.5472613741983334 1.0 0.8166823584190515 21 Q9UQ84,Q8IV08 2 +Acyltransferase 0.3273814978117036 0.4835822740557544 0.6286823572831666 1.0 0.8500982107183602 32 Q86UY6,P23786,Q8NCC3,Q96N66,Q9BWD1 5 +Endonuclease 0.3166074138247896 0.3096740642948269 0.7568088275639464 1.0 0.9260037874677616 19 Q9UQ84,O00584 2 +Methyltransferase 0.3012995713124346 0.2902623265041824 0.771615557817728 1.0 0.9260037874677616 40 O60725,P21964,Q8N6R0,Q96FX7,Q08J23 5 +Glycosyltransferase 0.29800784314588 0.2656461082284881 0.7905117717638612 1.0 0.9351175836718846 32 Q2TAA5,Q13126,P04062,P46977,Q86SF2,O43505,Q8NAT1,Q10472,Q8TCJ2,P13807 10 +Nuclease 0.29235276164856 0.2198158913908548 0.8260145427754984 1.0 0.9538501267764684 38 Q9Y3B8,Q9UQ84,O00584,Q8IV08 4 +Lyase 0.283084476189532 0.1562822442879427 0.875810551371835 1.0 0.9653820850348636 36 P53701,O00584,P12956,P22830,Q9P035,P61457,A1L0T0,P32929,P22234,P78549 10 +Decarboxylase 0.3154230165644081 0.0593055787916451 0.9527087177049952 1.0 1.0 6 P22234 1 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..dd3976a81bda7109c275f8782a8074a0dd8aa42b --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgG-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Potassium channel", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCC4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "ATR", "ATRX", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BANF1", "BAZ1B", "BAZ2A", "BCAT2", "BCKDHA", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BPHL", "BPNT1", "BPTF", "BRD1", "BRD2", "BRD4", "BRMS1L", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C12orf43", "CABIN1", "CAD", "CALD1", "CALR", "CAMK1", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBR4", "CBX3", "CBX8", "CCAR1", "CCAR2", "CCDC47", "CCDC51", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CERS1", "CERS2", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHM", "CHMP1A", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIRBP", "CKB", "CKMT1A*", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP2", "CTDSPL2", "CTH", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CUL5", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCD", "DCPS", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EFNB1", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERMP1", "ERO1A", "ERP44", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "F11R", "FADS2", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDE1", "GDI1", "GDI2", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLCE", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C5", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL3", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INF2", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIAA1147", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KRR1", "L2HGDH", "LAMP1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD3", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "M6PR", "MACF1", "MAGED2", "MAN2A1", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MATR3", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST2", "MGST3", "MICAL3", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MTA1", "MTA2", "MTAP", "MTF2", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTR", "MUT", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NARS2", "NAT10", "NAXE", "NCBP3", "NCL", "NCOA5", "ND5", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NF1", "NFKB2", "NGEF", "NHP2", "NIFK", "NIP7", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRDC", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "OSGEP", "OTUB1", "OTULIN", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDE8A", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM7", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHKB", "PI4K2A", "PIAS2", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PMF1", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R8", "PPP3CA", "PPP4C", "PPP5C", "PPT1", "PPT2", "PPWD1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS2", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSMD9", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALB", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RFX1", "RHOT1", "RHOT2", "RIC8A", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP7A", "RRP8", "RRP9", "RSF1", "RTCA", "RTCB", "RTF1", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAP30", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT2", "SHPK", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A2", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAF15", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TK1", "TKT", "TLK2", "TMCO1", "TMEM109", "TMOD1", "TMOD3", "TMTC3", "TMX3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1B", "TP53", "TP53BP1", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIR", "TRMT10C", "TRMT11", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSN", "TST", "TSTA3", "TTF2", "TTYH3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBR5", "UBTF", "UCHL5", "UCK2", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRFS1", "UROD", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTRN", "UXT", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS4A", "VPS4B", "VPS72", "VRK1", "WARS", "WARS2", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WNK1", "WTAP", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "ZADH2", "ZBED4", "ZC3H14", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFR", "ZMPSTE24", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687"], "leading_proteins": ["ABCB1", "ABCC4", "ACAT2", "ALG11", "ATP13A1", "ATP7B", "B4GAT1", "CLPP", "COLEC12", "COMT", "COX2", "CPD", "CPT2", "CPVL", "CTH", "CTSA", "CYP51A1", "DOHH", "ECE1", "ERMP1", "EXO1", "FCGRT", "FECH", "FNTA", "FUCA1", "FUCA2", "GAA", "GALNT1", "GALNT7", "GAPVD1", "GBA", "GLA", "GLB1", "GNA13", "GNAO1", "GNG12", "GYS1", "HACD3", "HCCS", "HEXA", "ICMT", "IGF2R", "ILVBL", "LNPEP", "LRP1", "LTA4H", "M6PR", "MBOAT7", "METTL13", "MGEA5", "MTAP", "NAA40", "NAGLU", "NNT", "NPC1", "NPEPPS", "NRDC", "NSUN2", "NTHL1", "NUCB1", "NUCB2", "PAICS", "PCBD1", "PITRM1", "PLA2G15", "PLD3", "PLXNB2", "POMGNT2", "PRCP", "PROCR", "PSMB5", "PSMB6", "PSMB7", "RAPGEF6", "REXO2", "RNASET2", "SCARB1", "SCARB2", "SCPEP1", "SIGMAR1", "SLC7A1", "STT3A", "STT3B", "TAP2", "TFRC", "TOMM22", "TPP1", "TRMT61A", "USP28", "USP47", 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-0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 21, + "title": "Average number of proteins per term", + "value": 471.0952380952381 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..060069b7c30cc20cd660b8652f5ac230022e1745 --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..311bed10a1fe4c46ab2627afafc37a74f5e13897 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,9 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.4940211304108612 2.16631644942431 0.0302870135745929 0.4757874109228688 0.159006821266613 556 Q9NR77,Q5VW38,Q6UW68,Q99595,O43772,Q93050,Q6NT16,Q8IXB1,Q8WTV0,Q8IXU6,P00846,P30519,Q9NS69,O00264,P42892,Q8N0U8,Q8NBX0,Q9UI14,O60830,P98172,Q14012,Q16850,Q567V2,O00592,Q9Y5M8,Q8N511,Q8IV08,Q9NPR9,Q14108,Q9Y487,P09601,Q8TB61,Q15904,Q8NE01,Q9P035,Q9H7Z3,P36551,P08183,Q9UG56,P53985,Q9UIQ6,Q9UBD5,Q15392,Q3SXM5,O00461,Q70HW3,Q9H4I3,Q9Y2R0,Q9NX00,O95831,O14925,Q9UH99,P41440,Q99808,P30825,O43169,P29372,Q8NBU5,O43676,P51812,Q8NEW0,Q13423,Q9HD20,P00403,Q9Y2W6,Q9NXW2,Q9Y282,O43657,Q8TAA9,Q9C0H2,O95772,P20645,Q92804,Q9NQX7,Q15629,P46977,Q07954,Q8NCC3,Q13505,O15118,Q9H4I9,Q86XL3,Q92896,Q99720,Q6UW02,Q9H2V7,Q9UDW1,Q8TAD4,Q96G23,Q9NR28,O15439,P39210,Q8IXM6,Q9Y584,Q8IZA0,O15260,Q9UNN8,Q9H061,O75381,O95249,Q03519,P43307,Q96EX1,Q16625,P46783,Q15800,Q6N075,Q86Y82,Q9BTX1,Q96GC9,O75976,O75964,O75027,Q96PC5,O15121,Q9UKU0,O15031,P11117,P35670,P37268,Q9UBU6,Q96JJ7,Q70UQ0,P57105,P03915,Q6P4Q7,Q8NC54,Q8NHH9,Q96N66,O95197,Q9UBX3,Q5KU26,Q15043,Q15631,Q9P2W9,P11717,P27544,Q07065,Q8IWA4,P55899,Q8IYS2,O75844,P10321,P56962,Q6NUM9,Q7Z3C6,O60725,Q6ZRP7,Q9H6K4,Q9H2J7,P56589,O15173,Q7Z2K6,Q14BN4,Q8N1F7,Q9UDX5,P62942,Q06136,Q8TBA6,Q9H1E5,P50402,O96005,Q9HD45,O14936,Q99567,Q96A33,Q15070,P02786,Q8TDW0,P51790,Q99805,O43674,Q8N5M9,Q96TC7,Q96QD8,Q96A26,P16615,Q8TCJ2,Q3ZCQ8,Q86UP2,Q13641,P16435,Q99523,O15344,P04439,A1L0T0,Q96ES6,Q9Y6M7,Q8NF37 189 +Candidate cardiovascular disease genes 0.6835286191814756 1.8744673636673683 0.0608660362688109 0.73252789941305 0.1837490523575236 9 Q07954,P06865,Q15165 3 +Predicted secreted proteins 0.4574822292086023 1.871688697555848 0.0612496841191745 0.7348131289318498 0.1837490523575236 49 Q8WUJ1,P14174,O00584,P07942,P80303,Q08380,Q9BTY2,Q15165,Q8N128,Q9UMX5,Q02818,Q9HB40 12 +Disease related genes 0.2494530225150851 1.6126141967096497 0.1068283522071464 0.9067532932896424 0.2804244245437595 997 O43772,P21964,P22830,P00846,P00813,O43924,P42892,P07602,Q8N511,P07099,P33991,Q8IV08,Q14108,Q9Y487,P09601,P50897,Q96CU9,P08183,P53985,O95684,Q15392,Q70HW3,Q9Y2R0,O95831,Q13126,O75503,P08670,O43676,P51812,Q13423,P00403,O14773,Q9NWM8,P53701,Q92804,P54802,P16278,P46977,Q07954,P06865,P07196,Q5VU43,O15118,P10619,Q86XL3,Q6DKK2,Q99720,Q16740,Q9H6R7,Q9NR28,P39210,P49366,Q96HY6,P55263,P46100,Q9Y584,Q08J23,Q9BPX6,Q9H061,O00584,P35637,Q16204,O75381,Q03519,Q13510,O14979,Q6NUQ1,Q8NI60,Q16625,P46783,Q15800,O14874,P28070,P55795,O75027,Q8NFH4,Q01105,P38159,Q96PC5,O15121,Q9UKU0,P11117,P35670,P37268,Q96GD4,P61978,P03915,Q6P4Q7,P23786,Q96N66,Q9H9P8,Q9BQT8,O00291,P48735,Q8N6R0,Q7Z4L5,P14174,P02545,P25705,Q15043,P98175,P27544,P16219,O15460,Q9UHX1,Q9H6U6,Q9BVA1,Q92796,Q93052,Q15067,P22695,O75844,P10321,Q03252,Q14004,P68371,P50570,Q96EK5,Q32P28,Q9H6K4,Q13813,P56589,Q9NSE4,Q03164,P23246,P22626,Q15233,Q8N1F7,Q969G3,Q96F07,Q06136,P10253,P07942,Q8TBA6,P50402,Q00577,P61457,Q01844,P78549,P04062,Q9UGU0,Q8TD16,O14936,Q99567,Q96A33,P21912,P02786,O43707,P20585,Q96CV9,Q9NQT5,P32929,Q96BR5,P07437,P12270,P40855,Q13868,P17480,O00459,Q8N5M9,P50995,P48449,P35580,O75569,Q4J6C6,P06753,P61313,P25325,P16615,P00374,Q8NAT1,Q9H4A3,Q8TCJ2,Q3ZCQ8,P16435,Q99523,Q13217,O60826,O14949,O15344,P06280,O43505 182 +Human disease related genes 0.2515647131541226 1.4863316353279072 0.1371914229024353 0.9548971974578596 0.2881019880951143 887 Q9NR77,O43772,P21964,P22830,P00846,P00813,O43924,P42892,P07602,Q8N511,P07099,P33991,Q8IV08,Q14108,Q9Y487,P09601,P50897,Q96CU9,P08183,P53985,Q15392,Q70HW3,O95831,O75503,P08670,O43676,P51812,Q13423,P00403,O14773,Q9NWM8,P53701,P54802,P16278,P46977,P06865,P07196,O15118,P10619,Q86XL3,Q6DKK2,Q99720,Q16740,Q9NR28,P39210,P49366,O96000,Q96HY6,P55263,P46100,Q9Y584,Q08J23,Q9BPX6,Q9H061,O00584,P35637,Q16204,O75381,Q03519,Q13510,O14979,Q6NUQ1,Q8NI60,Q16625,P46783,Q15800,O14874,P55795,O75027,Q8NFH4,Q9UPT5,Q01105,P38159,O15121,P11117,P35670,P61978,P03915,Q6P4Q7,P23786,Q96N66,Q9H9P8,Q9BQT8,P48735,Q9UBX3,Q7Z4L5,P14174,P02545,P25705,Q15043,P98175,P27544,P16219,O15460,Q9UHX1,Q9BVA1,Q92796,Q15067,P22695,O75844,P10321,Q03252,Q14004,P68371,P50570,Q96EK5,Q32P28,Q9H6K4,Q13813,P56589,Q9NSE4,Q03164,P22626,Q15233,Q8N1F7,Q969G3,Q96F07,Q06136,P10253,P07942,P50402,Q00577,P61457,P04062,Q9UGU0,Q8TD16,O14936,Q99567,P21912,O43707,P20585,Q96CV9,Q9NQT5,P32929,Q8TDW0,Q96BR5,P07437,P12270,P40855,P17480,O00459,P50995,P48449,O75569,Q4J6C6,P06753,P61313,P16615,P00374,Q8NAT1,Q9H4A3,Q8TCJ2,Q3ZCQ8,P16435,Q13217,O60826,O14949,O15344,P06280,O43505 160 +Metabolic proteins 0.2288714973446408 0.294920405131014 0.7680546838250948 0.9999999999999528 1.0 846 O43772,Q93050,P21964,P22830,Q8WTV0,P00846,P00813,Q9NPH0,P30519,O43924,Q8NBX0,Q16850,P07602,Q9UHG3,P07099,Q8IV08,Q9Y487,P09601,Q13011,P50897,Q9BWD1,Q15165,Q15418,P08183,P55786,P53985,Q15392,Q8N4Q0,Q70HW3,Q13126,P41440,O94788,P30825,Q86UY6,P30837,O15254,O43676,P51812,Q13423,P00403,O14773,Q9NWM8,P53701,P54802,P16278,P46977,P06865,Q8NCC3,Q9UMR5,Q9BTY2,O15118,P10619,Q9UDW1,Q96G23,O15439,P49366,O96000,P55263,Q7LGA3,O60658,P49354,Q13510,Q9HA64,Q9H773,Q15800,Q9BTX1,O14874,Q969T7,O75964,Q86SF2,Q8NFH4,O15121,Q9UKU0,P11117,P37268,Q96GD4,Q96JJ7,P03915,P23786,Q96N66,Q9H9P8,Q9BQT8,O60502,P48735,Q8N6R0,Q9UBX3,P14174,O43865,O14976,P25705,Q15043,Q96RU2,P27544,P16219,O15460,O75150,Q15067,P22695,O75844,Q14004,Q8TBX8,P50570,O60725,O75600,Q9H2J7,Q03164,P22234,Q8N1F7,Q9Y680,P62942,Q06136,P10253,Q9H0E3,P61457,Q96K76,P22392,P04062,P09960,O14936,Q99567,Q9NRN7,P21912,P02786,Q7Z3B4,P32929,P12270,O43674,O00459,Q9H2G2,Q9BRR6,Q96QD8 131 +Transporters 0.4107689789518953 0.2420503868781906 0.8087411207084556 0.9999999999999992 1.0 368 Q9NR77,Q5VW38,Q6UW68,O43772,Q93050,Q6NT16,Q16891,Q8WTV0,Q8IXU6,P55735,O60645,Q9UI14,P45880,P07602,Q8N511,Q8TB61,Q14108,Q15904,Q8NE01,P08183,P53985,Q70HW3,Q9UH99,P41440,Q99808,P30825,P57740,Q8NEW0,Q9HD20,P00403,Q9NXW2,Q8TAA9,Q9Y6C9,Q9C0H2,P20645,Q15629,P46977,Q07954,Q96A65,P06493,O96008,Q12769,O15118,Q9H4I9,Q99720,Q9H2V7,Q8TAD4,O15439,P39210,O15260,Q9BPX6,Q9H061,O75381,Q03519,Q16625,Q6N075,Q9BTX1,Q96GC9,O75027,Q8NFH4,Q9UPT5,Q96PC5,P35670,Q9UBU6,Q96JJ7,P57105,Q6P4Q7,Q8NHH9,Q96N66,Q9BQT8,Q9UBX3,O43865,Q15043,Q8IYU8,P11717,Q07065,Q8IWA4,O75844,P56962,P50570,Q7Z3C6,Q9H2J7,P56589,Q8N1F7,P62942,Q8TBA6,O96005,O43681,P08133,Q99567,Q96A33,Q15070,P21912,P02786,Q7Z3B4,Q96CV9,Q8TDW0,P12270,P40855,Q99805,Q96QD8,Q92973,Q8NFH5,P50995,P52292,P16615,Q8TCJ2,Q99523,O60826,P04439,Q12959,Q9Y6M7 112 +FDA approved drug targets 0.2924688779144942 0.1651243380754446 0.8688461169406974 1.0 1.0 120 P21964,P00813,P02786,Q8N0U8,P07437,Q9UNN8,Q16850,P49354,P09525,Q96QD8,P68371,P36404,P16615,Q13423,P20645,P62942,P10253,P23786,P49721,P28074,P48735,Q99720 22 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9242959669d23de745fe8e0a639e858ce4d9cc99 --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Nuclear receptors", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C3orf58", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM89A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMIM12", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM160", "TMEM161A", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM41B", "TMEM43", "TMEM65", "TMEM70", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13D", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFC3H1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCB7", "ABCC4", "ACADS", "ACAT2", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSL6", "ACTN4", "ADA", "ADK", "ADPGK", "AHCYL1", "AIFM1", "ALDH1A2", "ALDH1B1", "ANKLE2", "ANXA11", "ANXA4", "ANXA6", "ARL2", "ASAH1", "ASNA1", "ATAD1", "ATG9A", "ATL2", "ATP13A1", "ATP2A2", "ATP5A1", "ATP5L", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP7B", "ATRX", "AURKB", "B4GAT1", "BCAS3", "BCKDK", "BICD2", "C5orf15", "CAMK1", "CASK", "CCDC22", "CCDC47", "CCDC6", "CDK1", "CDK13", "CERS1", "CERS2", "CKAP4", "CLCN3", "CLN5", "CLPP", "CLPTM1", "CNNM3", "CNNM4", "COA3", "COA7", "COLEC12", "COMT", "COQ8A", "COX2", "CPD", "CPOX", "CPT2", "CTH", "CTSA", "CYB5B", "CYB5D2", "CYFIP2", "CYP20A1", "CYP51A1", "DCTPP1", "DDRGK1", "DEGS1", "DHCR24", "DHFR", "DHPS", "DIABLO", "DLG1", "DLG3", "DNAJB12", "DNAJC10", "DNAJC3", "DNM2", "ECE1", "ECH1", "EFNB1", "EMD", "EPHX1", "ERGIC3", "ERMP1", "EWSR1", "EXOC3", "EXOC4", "EXOC7", "EXOSC2", "EXOSC3", "FAM162A", "FAM177A1", "FAM8A1", "FCGRT", "FDFT1", "FECH", "FGFR1OP", "FKBP14", "FKBP1A", "FKBP7", "FN3KRP", "FNTA", "FOXRED1", "FUCA2", "FUS", "GAA", "GAK", "GALNT7", "GBA", "GCAT", "GLA", "GLB1", "GLG1", "GOLGA5", "GOLIM4", "GOSR1", "GPR107", "GPR108", "HACD3", "HCCS", "HEXA", "HIP1", "HLA-A", "HLA-C", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HS2ST1", "HSDL1", "IARS2", "ICMT", "IDH2", "IGF2R", "IKBIP", "ILVBL", "IMMT", "ITM2C", "JAGN1", "KDSR", "KIAA0319L", "KIAA2013", "KIFBP", "KMT2A", "KPNA2", "KTN1", "L2HGDH", "LAMB1", "LGALS3BP", "LMNA", "LMNB2", "LNPEP", "LPCAT1", "LPP", "LRP1", "LRRC8C", "LSS", "LTA4H", "M6PR", "MBOAT7", "MCM4", "METTL13", "MFN1", "MFSD3", "MFSD5", "MGEA5", "MIA2", "MICU1", "MICU2", "MID1", "MIF", "MPG", "MPST", "MPV17", "MPV17L2", "MSH3", "MSMO1", "MTAP", "MTCH2", "MTFP1", "MTX1", "MYH10", "NAA40", "NAGLU", "ND5", "NDC1", "NDUFB10", "NDUFB3", "NDUFB5", "NEFL", "NENF", "NME2", "NNT", "NONO", "NPC1", "NPEPPS", "NRDE2", "NRM", "NSUN2", "NT5C3B", "NTHL1", "NUCB1", "NUCB2", "NUP107", "NUP160", "NUP35", "NUP37", "NUP54", "NUP88", "NUP93", "OCLN", "OPA3", "OPTN", "ORC3", "OXA1L", "P3H1", "P4HA2", "PAICS", "PCBD1", "PCYOX1", "PDE4DIP", "PDE6D", "PDE8A", "PEX14", "PEX19", "PEX3", "PGRMC1", "PGRMC2", "PIK3R2", "PIP4K2C", "PISD", "PLA2G15", "PLD3", "PLXNB2", "PODXL", "POMGNT2", "PON2", "POR", "PPT1", "PPT2", "PREPL", "PRKRA", "PROCR", "PSAP", "PSMB2", "PSMB4", "PSMB5", "PUF60", "PURA", "PXMP2", "QSOX2", "RABAC1", "RBM10", "RBMX", "RETSAT", "RINT1", "RMDN3", "RNASET2", "RNF40", "RPL15", "RPS10", "RPS6KA1", "RPS6KA3", "RTN3", "SAP130", "SCARB1", "SCARB2", "SCCPDH", "SCPEP1", "SDHB", "SEC13", "SET", "SFPQ", "SIGMAR1", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A20", "SLC25A21", "SLC25A26", "SLC29A1", "SLC30A5", "SLC30A7", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC4A7", "SLC6A15", "SLC7A1", "SLK", "SLMAP", "SMARCE1", "SMDT1", "SMIM12", "SORT1", "SPNS1", "SPTAN1", "SRPRB", "SSR1", "STARD3NL", "STT3A", "STT3B", "STX12", "STX17", "STX18", "SUN2", "SURF4", "SYNJ2BP", "TAF15", "TAP2", "TCF20", "TDRKH", "TFRC", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM50", "TM9SF2", "TM9SF3", "TMEM126A", "TMEM160", "TMEM199", "TMEM205", "TMX3", "TMX4", "TNPO1", "TOMM22", "TOMM40", "TPBG", "TPM3", "TPP1", "TPR", "TRABD", "TRAM1", "TSN", "TSPAN6", "TTC19", "TTC21B", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "UBTF", "UQCR10", "UQCRC2", "UQCRQ", "USP28", "USP47", "VANGL1", "VDAC2", "VIM", "VKORC1L1", "VMP1", "WDCP", "WNK1", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/advanced/idx2term.json b/protein_atlas_subcellular_location_all/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..d095ff36e63ce4e9059687d70af89a33bb9987fa --- /dev/null +++ b/protein_atlas_subcellular_location_all/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Nuclear membrane"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/advanced/plot_0.png b/protein_atlas_subcellular_location_all/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..3c98246e77b0618df908c34d949d338ba33434f6 --- /dev/null +++ b/protein_atlas_subcellular_location_all/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:27c5ab49d1ea6c73a22b66fa149618c7a1302f0991b86184e4867ac137cf16f8 +size 193177 diff --git a/protein_atlas_subcellular_location_all/basic/idx2term.json b/protein_atlas_subcellular_location_all/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..5b6cc1a83018a5c469eba473db666ecb645f1362 --- /dev/null +++ b/protein_atlas_subcellular_location_all/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Nuclear membrane", "1": "Golgi apparatus", "2": "Focal adhesion sites", "3": "Centriolar satellite", "4": "Endoplasmic reticulum"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/basic/plot_0.png b/protein_atlas_subcellular_location_all/basic/plot_0.png new file mode 100644 index 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--- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Nuclear membrane 17 64 2.095164934244856 0.0361563332490693 16.817961165048544 62.713592233009706 0.5402747034161678 0.5293388535672136 7.339768502370818 5.865441797870943 1.2287110387783358 0.3803813474041967 0.2797448300044758 0.5796059904208676 0.513981822243311 0.1466093465578581 0.1727190931371662 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0b763457005e09f15faeacb1033d33a4db76c830 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3069, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 142.27272727272728 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..72b489487ba31dad41d56a61ee9fb337a77d7167 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C433/C433_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..da415eb5f56c96937856296d5e04de0c99cbe3e0 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,10 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Nuclear membrane 0.4158401418896947 2.095164934244856 0.0361563332490693 0.703368180777636 0.4827854882381238 64 P12270,Q9UH99,P20700,Q6UW68,O95619,O75976,Q14739,Q96G23,P57740,Q9H1E5,P50402,Q8IXM6,Q8NFH5,Q9NXW2,Q03252,O15260,Q9BTX1 17 +Golgi apparatus 0.4691869891735045 1.8917863469502647 0.0585194531197725 0.8632980905096512 0.4827854882381238 167 Q9H2V7,Q5KU26,Q9HD45,Q5VW38,O14976,Q8TD16,Q5BKZ1,Q8TAD4,Q93050,Q6NT16,Q15043,O15439,Q8IXU6,P11717,Q02818,Q9HB40,Q8IZA0,O15260,Q969S3,Q96C57,O60658,O15212,Q8IYS2,Q9NPR9,P09601,P50897,P80303,Q6NUQ1,Q14004,Q8N4Q0,O00461,Q86Y82,P50570,O00231,Q6ZRP7,Q86SF2,Q8NEY8,Q9NWM8,P35670,Q9UBU6,P16278,Q8TBA6,Q8NC54,Q96GI7,Q5VU43,A9UHW6,Q92896 47 +Focal adhesion sites 0.394140814771081 1.0245824228181362 0.305560261712622 0.9999940578906948 1.0 27 Q9Y3B8,Q9Y487,Q93052,P36404,P08183,Q9Y6M7,O60888 7 +Centriolar satellite 0.3824137602796493 0.9374760391404906 0.348513743323007 0.999999277440638 1.0 24 Q7Z4H7,O43169,Q86UY6,O15344,Q9UBK9,P41208 6 +Peroxisomes 0.4197699601764367 0.9324837175750124 0.3510865975463333 0.9999993658929918 1.0 17 O75381,Q15067,O15254,P56589 4 +Kinetochore 0.6957939354418036 0.549501805545108 0.5826611258354855 0.9999999999997008 1.0 2 Q9NQS7 1 +Lipid droplets 0.3557856115997543 0.2416061826388581 0.8090853309490207 1.0 1.0 9 Q01105 1 +Endoplasmic reticulum 0.3413530384505794 0.152603494281314 0.878710969240784 1.0 1.0 194 Q8WUJ1,Q6UW68,Q15043,Q96G23,P21964,Q15631,O43852,Q9P2W9,Q96HY6,Q8N0U8,P27544,O15260,O15460,Q14257,Q16850,Q8IV08,Q03519,P43307,Q15800,Q96GC9,Q92791,O43169,Q9H3G5,Q96PC5,Q14BN4,P37268,Q9Y680,Q96F07,Q70UQ0,Q8NHH9,P50402,O95197,Q86XL3,P67809 34 +Intermediate filaments 0.2761649135435541 0.1189264112621893 0.9053336570894036 1.0 1.0 33 P07196,Q16352,P08670 3 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..c5b8aa4e62ccf5380916c747ed0bfa6f68bb443d --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ADA", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC5", "ARVCF", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1B3", "ATP2B1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHID1", "CHM", "CHMP1A", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COQ5", "COQ8A", "CORO1B", "COTL1", "COX15", "COX4I1", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOHH", "DPF2", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELP1", "ELP2", "ELP3", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM3C", "FAM49B", "FAM50A", "FAM89A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNE", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GPAA1", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HGH1", "HGS", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMF2", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEFL", "NEFM", "NELFA", "NELFCD", "NELFE", "NEMF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NIF3L1", "NIFK", "NIP7", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSUN2", "NSUN5", "NT5DC1", "NT5DC3", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE4DIP", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLFN11", "SLIRP", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMIM12", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD2", "SNRPD3", "SNTB2", "SNW1", "SNX1", "SNX2", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPC25", "SPCS2", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRIP1", "STRN", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMEM109", "TMEM126A", "TMEM161A", "TMEM167A", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM41B", "TMEM70", "TMOD3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC37", "TTC38", "TTC4", "TTF2", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13D", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR77", "WDR82", "WIZ", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZFC3H1", "ZFR", "ZFYVE16", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ACOX1", "ACOX3", "ANKLE2", "ARL2", "ATL2", "ATP6V0A1", "ATP6V0A2", "ATP7B", "BICD2", "C12orf43", "C5orf15", "CALU", "CDK13", "CERS1", "CERS2", "CETN2", "COLEC12", "COMT", "CPD", "CPVL", "CUTA", "CYB5B", "CYB5D2", "CYFIP2", "CYP51A1", "DDRGK1", "DNAJB12", "DNM2", "EMD", "FAM89A", "FAM8A1", "FDFT1", "FKBP14", "FKBP7", "GAK", "GALNT7", "GLB1", "GLG1", "GOLGA5", "GOLIM4", "GPR107", "GPR108", "HAUS6", "HMOX1", "IGF2R", "IKBIP", "INA", "INCENP", "KIAA0319L", "KIAA2013", "LBR", "LMNB1", "LMNB2", "LPP", "MIA2", "MID1", "MIF4GD", "MSMO1", "NAA40", "NDC1", "NEFL", "NRM", "NUCB1", "NUCB2", "NUP107", "NUP35", "P3H4", "P4HA2", "PDE4DIP", "PDE8A", "PEX14", "PEX3", "PFDN6", "PLD3", "PPHLN1", "PPT1", "PSMD11", "QSOX2", "RCN2", "REXO2", "RINT1", "RTN3", "SCPEP1", "SET", "SLC18B1", "SLC30A5", "SLC35F2", "SLC39A14", "SLC4A7", "SLMAP", "SPNS1", "SSR1", "STX12", "STX18", "SUN2", "SURF4", "TAP2", "TM9SF3", "TMEM205", "TMX4", "TPR", "TSN", "UXT", "VIM", "VKORC1L1", "VMP1", "YBX1", "YEATS4", "ZADH2", "ZNF326", "ZNF622"]} \ No newline at end of file