diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..884813dd16650df34831385d765007d0befa28c2 --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Serine/threonine-protein kinase, active site [IPR008271]"} \ No newline at end of file diff --git a/interpro_active_site/advanced/plot_0.png b/interpro_active_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..db788f501eb8503379b053cb35ec813cfcca7ce1 --- /dev/null +++ b/interpro_active_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:94739f66a09811cdc201802077b83d514c015009f3c8fa4377d827afbb1da764 +size 197324 diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..884813dd16650df34831385d765007d0befa28c2 --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Serine/threonine-protein kinase, active site [IPR008271]"} \ No newline at end of file diff --git a/interpro_active_site/basic/plot_0.png b/interpro_active_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..3e39d0a7a3068f2248728d3b40549818296c0816 --- /dev/null +++ b/interpro_active_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:154873a6489a7130bee046a8022ee1db7a12033310df2e44fb8e662fe0952805 +size 143605 diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..04f4f3c22d2214b226f264bb8083b7d128c3246c --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:80fa982e8b5c71d3b77464f071f88998c4237ee2044c66cd18cf5cd9ca57935f +size 73991 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cf10db766bdf6d02b772f7696a50c760e73894d5 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Serine/threonine-protein kinase, active site [IPR008271] 7 41 2.4987712052618667 0.0124624742418748 14.96359223300971 48.092233009708735 -0.2514056606840174 0.5845564538757478 7.386430402173519 10.05983255009733 0.9463339478376924 0.3271131887386243 0.0063207257946983 0.0050214847839442 0.0074675389615573 0.2044744712587262 0.4591779800392646 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..4710ba642d4a7279a111d8561812cd971d17b287 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 53, + "title": "Average number of proteins per term", + "value": 2.509433962264151 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..4ea510619e3f73e91c1fa2529681764131329a8a --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6fd8ea456dca409bd0f2f64e1fa2756d20bef7b1 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine/threonine-protein kinase, active site [IPR008271] 0.596231173707765 2.4987712052618667 0.0124624742418748 0.485552337851286 0.0802733118404992 41 Q96GD4,Q14004,P49840,P49841,P53350,P06493,P24941 7 +Serine carboxypeptidase, serine active site [IPR018202] 0.7583359607277379 0.7625575425959271 0.4457273135082031 0.999999999999974 0.5969288985955862 3 Q9HB40 1 +Tyrosine-protein kinase, active site [IPR008266] 0.4782536279407309 0.3388247814060341 0.734741731512544 1.0 0.7518952880135333 4 P07948 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a64d13e30dc0f70ae1547e47bb8d9ef7d3cc180e --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MDH1", "MDH2", "MTMR2", "NEK9", "NME1", "NME2", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1", "WNK1"], "leading_proteins": ["AURKB", "CDK1", "CDK13", "CDK2", "GSK3A", "GSK3B", "LYN", "PLK1", "SCPEP1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..465c03bba181ece1b3cfc758ab37913f62157507 --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Protein kinase, ATP binding site [IPR017441]"} \ No newline at end of file diff --git a/interpro_binding_site/advanced/plot_0.png b/interpro_binding_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..aaf504155b162ac6ee3289a683ca30068941b213 --- /dev/null +++ b/interpro_binding_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3f75f6c7a814cfed422ff8d73e6fff85cd63a8c37974acf1f46967e5925ae558 +size 194499 diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..dd9aa1e45c0dcd223f6c2f11928a16ff34f0689e --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Protein kinase, ATP binding site [IPR017441]", "1": "IQ motif, EF-hand binding site [IPR000048]", "2": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2be1f7541a877fbfad05749cb826a7feb81965eb --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:62cfa67ccd03d5cdccb1a445914b1e0dd8f436f36024ae7077c80072d9579e6d +size 143620 diff --git a/interpro_binding_site/basic/plot_1.png b/interpro_binding_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..3521b42b07cd0cd566b2147043bbf436ff12dbb3 --- /dev/null +++ b/interpro_binding_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7eee8cc3c6db78ac7db41c9e3a596d114e21d02cc56253db1618726587f7881c +size 139930 diff --git a/interpro_binding_site/basic/plot_2.png b/interpro_binding_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..d738cdf0544c7a46fc34189fb767b62ecb4300e9 --- /dev/null +++ b/interpro_binding_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ad28df1d8a9032ac7773f8e6768577acc6473bca26ec701e580d04ee6b9b41e7 +size 149290 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5873348247175091bfc27c56381f4f143a026c9e --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c5c585fdd3acccbe7b759bd9109c07edac4b1ed0d5c45903b6359a36f4eb0435 +size 72374 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..26b84e0aee7fabc991b8b42ea3ac6e5c8f37279e --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Protein kinase, ATP binding site [IPR017441] 6 38 2.784192327709319 0.0053661204502593 13.985436893203884 45.86407766990291 -0.192126652758297 0.6147860592683837 6.814446501353132 9.80766348241306 0.8651595242963739 0.3198537516496491 0.0092928710635474 0.0089711696955549 0.0153222017526981 0.4742136955175234 0.7591061197161084 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..29a5bafb9f8c74178a3fc22db923765814f82ba7 --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 29, + "title": "Average number of proteins per term", + "value": 4.482758620689655 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b9308fa20f0dad1fd4b281b7214c02e4c9d3bac2 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d7fbb93c5aa3b6cb430a2564661fa3ec20d9d93a --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein kinase, ATP binding site [IPR017441] 0.6450894159294152 2.784192327709319 0.0053661204502593 0.1444720574015253 0.0885556216913772 38 Q96GD4,Q14004,P49840,P49841,P06493,P24941 6 +Peptidase M16, zinc-binding site [IPR001431] 0.7462027515506773 1.5940945218286404 0.110914865730511 0.9669358688472932 0.2474254697065245 5 P22695 1 +IQ motif, EF-hand binding site [IPR000048] 0.4900125592785331 0.8750709085839133 0.3815353248325781 0.9999991125741536 0.582343390533935 10 O00159,P35579,Q9Y4I1,Q7Z406,P35580 5 +EF-Hand 1, calcium-binding site [IPR018247] 0.3029126546336455 0.2161281463791372 0.8288878605194079 1.0 0.858490998395101 36 Q9Y680,Q14257,P80303,Q9NWM8,O43852 5 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..6480042579cf597eb39a903a045ea781b8bcc050 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "ARG2", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MCCC1", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1F", "PPM1G", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK4", "TKT", "TLK2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["AURKB", "CALU", "CDK1", "CDK13", "CDK2", "FKBP14", "FKBP7", "GSK3A", "GSK3B", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO5A", "NUCB2", "RCN2", "UQCRC2"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9d7465e476a70a443a1c142b8afd0e222282abe1 --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Thioredoxin, conserved site [IPR017937]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..eef347237dfe735001a9883889940f2d39d269be --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:82b70c040101d00982bf281e1c0ff305893fe770fed5e57595cfb719ed238292 +size 194893 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..64f070e842a40d11a1cdf9212b1713060d6a38ff --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Thioredoxin, conserved site [IPR017937]", "1": "Kinesin motor domain, conserved site [IPR019821]", "2": "14-3-3 protein, conserved site [IPR023409]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..db38c6e4b68a570111c489597eeadb9b590b029c --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:337d0d290f7a7cf31272390512307bd6c7d1392d5ad53db93d9fe13679a82bad +size 137874 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..6b954c19aeceb23d8eb1c78868698a733d7733b5 --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:292418321686c5fb836c476e51c3dee60b9ac7b8232ce9cd8a8d5eb0057719db +size 150335 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..ca1f043b8bce9cda8b4cc7015e71b3c913c9d2db --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1c63ade15c5d62e843dd54486254e07f89216837f2ca0f975d5b05caba7b0e98 +size 138079 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0eed425e2e931ee1747af689f0c5ecd05464aa32 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:47b9e3b83f4df8f4dd0d9f627bdf3a08a3c72ff57e2110a33525ad60fc2ae3d3 +size 86539 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e48a7a4c29beadf88445f87db0bb7e6e8016e999 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Annexin repeat, conserved site [IPR018252] 3 6 2.449812039910771 0.0142930804496084 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 0.075113296023457 2.1797401302891516e-05 0.0003286021100258 +Thioredoxin, conserved site [IPR017937] 9 11 2.2671033774882905 0.0233839113089662 3.905339805825242 10.99514563106796 0.4926509002179139 0.4659055513701703 2.3960466288532025 1.0404329420711995 1.0069927416530815 0.3218319873274993 1.0 1.0 1.0 0.0041946485896371 2.246895762258043e-09 +ABC transporter-like, conserved site [IPR017871] 2 10 2.090669023806494 0.0365577436006949 2.7694174757281553 10.218446601941748 0.3896442308636141 0.4819689640161482 2.0043003889175366 2.2319066503087304 0.948959154182388 0.2971074262916467 0.0360824876045856 0.1006582454154426 0.1933613304033528 0.0153906222854723 0.088385561156941 +Aldehyde dehydrogenase, cysteine active site [IPR016160] 1 7 2.08748385654283 0.0368444188288332 2.478155339805826 7.286407766990291 -0.1163447967243902 0.4155558234730984 1.8026432844079276 0.5916159446457568 1.150914295148441 0.2845969995849257 1.0 0.0012105019492812 0.0048484802924912 0.027832231049335 0.0968157430558884 +Proteasome beta-type subunit, conserved site [IPR016050] 3 8 2.066151562988761 0.0388141707774281 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 0.0470522829573702 0.0001014210629885 6.292953854873037e-05 0.0009118158302113 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..82df6c87cabef67282ce2d01749b87c204489e85 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 271, + "title": "Average number of proteins per term", + "value": 2.7195571955719555 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c25d6c0a045f71b44683eff6eed35ebf235c202d --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4fc14755e5948db8e7cc99edcf1b078398a10ce0 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,30 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Annexin repeat, conserved site [IPR018252] 0.9192687687169844 2.449812039910771 0.0142930804496084 0.9797858619995048 0.1916394422145041 6 P20073,P09525,P50995 3 +Thioredoxin, conserved site [IPR017937] 0.7535155424931516 2.2671033774882905 0.0233839113089662 0.9983587679105972 0.2044206440235434 11 P30101,Q8NBS9,P07237,Q15084,Q9H3N1,O43396,Q8IXB1,O95881,P13667 9 +ABC transporter-like, conserved site [IPR017871] 0.7398750938378716 2.090669023806494 0.0365577436006949 0.9999586227028856 0.2435326220149711 10 P08183,O15439 2 +Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.7907999642110886 2.08748385654283 0.0368444188288332 0.9999618287176206 0.2435326220149711 7 O94788 1 +Proteasome beta-type subunit, conserved site [IPR016050] 0.7713633341825642 2.0661515629887615 0.0388141707774281 0.9999780823297376 0.2477137342449646 8 Q99436,P28070,P49721 3 +Guanylate kinase, conserved site [IPR020590] 0.7780547029795177 1.8738798984213416 0.0609469806585454 0.9999999602789488 0.3354252536524489 6 O14936,Q14168,Q5T2T1,Q92796 4 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.8645377722669457 1.7649028269340346 0.0775800985150789 0.9999999996869108 0.3425423468869091 4 Q8N4Q0 1 +Aldehyde dehydrogenase, glutamic acid active site [IPR029510] 0.7094483154470831 1.7311579474060408 0.0834235973968118 0.9999999999440616 0.3425423468869091 7 O94788 1 +Intermediate filament protein, conserved site [IPR018039] 0.6305810944708755 1.427295545127964 0.1534947241556155 1.0 0.4781272442088712 8 Q16352,P07197,P08670,Q03252 4 +Sterol reductase, conserved site [IPR018083] 0.9096247960848264 1.358317102155378 0.174363085862115 1.0 0.5250266252070352 2 Q14739 1 +Haem oxygenase conserved site [IPR018207] 0.8456769983686712 1.107093228698164 0.2682536228221956 1.0 0.6346199497833976 2 P30519 1 +Ubiquitin interacting motif [IPR003903] 0.5826340032789505 0.9148498917351572 0.3602704386867867 1.0 0.7382800570112266 5 Q92783,Q9Y6I3 2 +AMP-binding, conserved site [IPR020845] 0.4997485309471545 0.7798176179608532 0.435498234709994 1.0 0.8144331835001343 7 P33121 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.7321370309950956 0.6836883990893567 0.4941719505348028 1.0 0.8196632966180166 2 Q16836 1 +Syntaxin/epimorphin, conserved site [IPR006012] 0.4481019650822613 0.557267224367201 0.5773448656375804 1.0 0.8569455199991289 7 Q86Y82 1 +EGF-like calcium-binding, conserved site [IPR018097] 0.660358890701463 0.4497781081461503 0.6528704445548263 1.0 0.8569455199991289 2 Q07954 1 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.6470207647048241 0.4224703360688546 0.6726817482930367 1.0 0.8569455199991289 3 P04439 1 +DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.3287666040669923 0.3233843134725089 0.7464042079148907 1.0 0.8570997472243025 14 Q7Z478,Q8IX18,Q12873 3 +Kinesin motor domain, conserved site [IPR019821] 0.3393525832511516 0.2540177390061765 0.7994818537351294 1.0 0.8879491080418854 11 O00139,O95239,P33176,Q99661,Q8NI77 5 +Histidine triad, conserved site [IPR019808] 0.5706362153344082 0.2239241754069228 0.8228163040824601 1.0 0.906435847180271 2 Q9BX68 1 +Chromo domain, conserved site [IPR023779] 0.3588092280764576 0.188706119662 0.8503231549697294 1.0 0.9329456477603104 6 P45973,Q12873 2 +14-3-3 protein, conserved site [IPR023409] 0.3511924207775224 0.1695940073191553 0.8653294357436558 1.0 0.9455817624456884 6 P62258,Q04917,P63104,P61981,P31946 5 +Ubiquitin specific protease, conserved site [IPR018200] 0.2880436470109863 0.1137504512573894 0.9094356177160012 1.0 0.970303355909592 12 Q9P275,Q96K76,Q96RU2 3 +DnaJ domain, conserved site [IPR018253] 0.2951782037293695 0.0970213060126255 0.9227094745168553 1.0 0.9806049709571284 10 Q96EY1,Q96KC8,O60884,Q99543 4 +Ribosomal protein L3, conserved site [IPR019926] 0.455138662316456 0.0719913751789677 0.942608771652369 1.0 0.990104562472062 2 P39023 1 +Vinculin, conserved site [IPR000633] 0.4401305057096112 0.0626437361245019 0.9500502013966752 1.0 0.9916019327315096 2 P35221 1 +Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867] 0.4362153344208744 0.060511852962032 0.95174797585168 1.0 0.9916019327315096 2 P13995 1 +Ribosomal RNA adenine methylase transferase, conserved site [IPR020596] 0.3448613376835243 0.0361117728409099 0.97119323508202 1.0 0.9916019327315096 2 Q9UNQ2 1 +RNA polymerase, beta subunit, conserved site [IPR007121] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 0.9916019327315096 2 Q9H9Y6 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f9a543baacf04ef9a49a6865f49c7fcf729f91b4 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3'5'-cyclic nucleotide phosphodiesterase, conserved site [IPR023174]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ephrin, conserved site [IPR019765]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7B", "ATR", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCR", "BCS1L", "BDH2", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD3", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFNB1", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK1", "FOXO3", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPAD1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NFKB2", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSD3", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDE8A", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF2", "PHF3", "PHGDH", "PHIP", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RIOK2", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLC5A6", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIM4", "TRIP13", "TRMT11", "TSFM", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR7", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ABCC4", "ACSL1", "ALDH1A2", "ANXA11", "ANXA4", "ANXA7", "CASK", "CBX5", "CHD3", "CTNNA1", "DHX29", "DHX40", "DIMT1", "DLG3", "DNAJA2", "DNAJA3", "DNAJC1", "DNAJC10", "DNAJC2", "EPN1", "HADH", "HINT2", "HLA-A", "HMOX2", "INA", "KIF18A", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LBR", "LMNB2", "LRP1", "MPP2", "MPP7", "MTHFD2", "NEFM", "P4HB", "PDIA3", "PDIA4", "PDIA6", "POLR1B", "PSMB2", "PSMB4", "PSMB7", "RPL3", "STAM", "STX12", "TMX1", "TXNDC12", "TXNDC5", "TXNL1", "USP28", "USP36", "USP47", "VIM", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2"]} \ No newline at end of file diff --git a/interpro_domain/advanced/idx2term.json b/interpro_domain/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..8bc2b734c587f034fcfc155bc1201eb0710472fa --- /dev/null +++ b/interpro_domain/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": 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@@ +version https://git-lfs.github.com/spec/v1 +oid sha256:12a05f11c9418783d2aa638502f585f705422a67926dd1ec0abb07423ca1a5e3 +size 286962 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..82f7549c619802e0e138ced27d2bd6ebe8126b14 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Protein kinase domain [IPR000719] 13 50 2.414098383839686 0.0157742023639271 18.101941747572816 59.74514563106796 -0.2447486486560373 0.6172415587925009 8.775755222472991 12.77818988078034 0.8704293873391331 0.3201152559326328 0.0167068620501439 0.0212294863462139 0.0429961144842739 0.5605944861064527 0.7492044156830103 +Major facilitator superfamily domain [IPR020846] 3 5 2.284835166204188 0.0223224947999258 1.8883495145631068 4.121359223300971 0.8776223597987594 0.2728824130413255 1.233496960525634 1.4580976091979958 1.2936014196902064 0.266909732326598 0.0488968448910572 0.134742527043449 0.0029806631250197 0.0056128198685199 0.0553856285019619 +ABC transporter type 1, transmembrane domain [IPR011527] 2 6 2.2115063660936296 0.0270007915217753 2.3689320388349513 6.349514563106796 0.6640264147492347 0.3307390797434538 1.7803691733569 2.1393617497725477 1.1694677427725269 0.279101120079799 0.0247368002912169 0.0697581245313758 0.1362380906066266 0.0051503840765812 0.0334620993119388 +Disulphide isomerase [IPR005788] 4 5 2.1957804117977053 0.0281076643585296 3.5364077669902914 5.0 -0.5459611161161633 0.4588527184578146 1.242896206188252 0.0 0.9547102446278944 0.316620713191972 1.0 1.0 1.0 0.1154193350298319 2.6454681464607386e-07 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 3 6 2.135003648272135 0.0327607121192905 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 1.0 0.0014481500629001 0.0057815105752346 0.0328731354880699 0.0001575214550341 +ABC transporter-like, ATP-binding domain [IPR003439] 2 10 2.090669023806494 0.0365577436006949 2.7694174757281553 10.218446601941748 0.3896442308636141 0.4819689640161482 2.0043003889175366 2.2319066503087304 0.948959154182388 0.2971074262916467 0.0393012238682757 0.1093006244161378 0.208984012191681 0.0195244436529747 0.1083207684216986 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c5b0522a6a0f358f7159838afa60801a1a31527f --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 2557, + "title": "Average number of proteins per term", + "value": 2.1662104028158 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..1af2793606da57b4592cbe63c703a09e98a7f338 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1619d43bcc7dcaabb8b772b970860d2b4f575424 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,236 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein kinase domain [IPR000719] 0.5511576136587395 2.414098383839686 0.0157742023639271 1.0 0.178952097707444 50 Q96GD4,P07948,Q14004,O14936,P49840,Q13464,P49841,P17252,O14976,P53350,P06493,P24941,P21127 13 +Major facilitator superfamily domain [IPR020846] 0.918731458146013 2.284835166204188 0.0223224947999258 1.0 0.1867944284997718 5 Q6NT16,P53985,Q14728 3 +ABC transporter type 1, transmembrane domain [IPR011527] 0.8597507106721607 2.2115063660936296 0.0270007915217753 1.0 0.1944456749572566 6 P08183,O15439 2 +Disulphide isomerase [IPR005788] 0.8958197256694976 2.1957804117977053 0.0281076643585296 1.0 0.1955152369693741 5 P30101,Q15084,P13667,P07237 4 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.8409825631048321 2.135003648272135 0.0327607121192905 1.0 0.2092513569358991 6 Q9UMX5,Q8WUJ1,O15173 3 +ABC transporter-like, ATP-binding domain [IPR003439] 0.7398750938378716 2.090669023806494 0.0365577436006949 1.0 0.2184068934275164 10 P08183,O15439 2 +Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091] 0.7047566772426218 1.9257212129431025 0.0541391936863531 1.0 0.2516980331927362 10 O15254 1 +Alcohol dehydrogenase-like, C-terminal [IPR013149] 0.7229095008980404 1.7909789344821918 0.0732966755035917 1.0 0.2933014072968453 7 Q8N4Q0,Q8N8N7 2 +RNA recognition motif domain [IPR000504] 0.4657188423335879 1.7767451049322092 0.0756101874881152 1.0 0.2997445727242024 120 Q9UKM9,Q93062,P07910,Q14966,Q01844,P51991,P31943,P31942,Q99729,Q15233,Q96PK6,P98179,P18615,P35637,Q96I25,P98175,O14979,Q08170,Q13243,Q13595,Q16630,Q5T8P6,Q8IUH3,P23588,P31483,O43390,Q12849,Q9UKA9,Q9P2K5,Q96T37,Q9NWH9,P09012,Q16629,P78332,P19338,P23246,P84103,Q9P2N5,Q9NTZ6,Q92804,Q8IY67,Q96E39,P22626,Q8WUA2,P33240,Q14011,O95104,Q76FK4,Q13242,Q8WXF1,Q9Y4C8,Q9Y6M1,Q9BWF3,Q8N684,O75494,P38159,P52597,Q92879,P09651,P55795,P62995,Q13151,Q8WVV9,Q07955 64 +Aldehyde dehydrogenase domain [IPR015590] 0.688746832669473 1.7552678100381778 0.0792135098206126 1.0 0.3059651731288616 9 O94788 1 +Intermediate filament head, DNA-binding domain [IPR006821] 0.8482026704292084 1.7019759207438638 0.0887598822410433 1.0 0.3233034457127463 4 Q16352,P08670 2 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.6820957444047933 1.665095020283002 0.0958938000715563 1.0 0.3363517788518101 8 O14936,Q14168,Q5T2T1,Q92796 4 +Guanylate kinase-like domain [IPR008144] 0.6820957444047933 1.665095020283002 0.0958938000715563 1.0 0.3363517788518101 8 O14936,Q14168,Q5T2T1,Q92796 4 +Glycogen synthase kinase 3, catalytic domain [IPR039192] 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.3387783748112465 2 P49840 1 +Polyketide synthase, enoylreductase domain [IPR020843] 0.6832132042792195 1.6136859574817457 0.1065955613841893 1.0 0.3558083445519779 7 Q99536,Q8N4Q0 2 +Peptidase M16, N-terminal [IPR011765] 0.6738721830758511 1.5715984053406644 0.1160437165374896 1.0 0.3723203598216419 7 Q10713,P22695 2 +Peptidase M16, C-terminal [IPR007863] 0.6738721830758511 1.5715984053406644 0.1160437165374896 1.0 0.3723203598216419 7 Q10713,P22695 2 +L27 domain [IPR004172] 0.8142365149684784 1.570318587834194 0.1163410119270598 1.0 0.3723203598216419 4 O14936,Q5T2T1 2 +L27 domain, C-terminal [IPR014775] 0.8142365149684784 1.570318587834194 0.1163410119270598 1.0 0.3723203598216419 4 O14936,Q5T2T1 2 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.9546492659053804 1.536723977575545 0.1243609168351516 1.0 0.3835836723130068 2 O15254 1 +MHC class I-like antigen recognition-like [IPR011161] 0.7301446380813224 1.5277463674808622 0.1265755229730487 1.0 0.3871454691890977 5 Q9UNN8 1 +Oxidoreductase, N-terminal domain [IPR041694] 0.95138662316476 1.5237886279102455 0.1275615212541692 1.0 0.3890442384711441 2 Q8N8N7 1 +BRCT domain [IPR001357] 0.6455844667780494 1.4969357876016725 0.1344099670724836 1.0 0.3996352160515589 8 P09874 1 +Rho GTPase-activating protein domain [IPR000198] 0.7136401188262136 1.4593040054071271 0.1444814534718577 1.0 0.4188651661309979 5 Q9H0H5,O00459 2 +LIS1 homology motif [IPR006594] 0.6794710048648908 1.4521682862335363 0.1464548184566276 1.0 0.4214460938991652 6 Q13428,Q14978,Q96S59 3 +Linker histone H1/H5, domain H15 [IPR005818] 0.6783632228149052 1.4473609746085505 0.1477958498046878 1.0 0.4222502658665774 6 P16403,P07305,P10412 3 +ERAP1-like C-terminal domain [IPR024571] 0.7817896269272135 1.443737775793667 0.1488127510734087 1.0 0.4228658600562264 4 P55786 1 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9513707571801592 1.441292605579667 0.1495020354304097 1.0 0.424101760151581 3 P27544,Q96G23 2 +Intermediate filament, rod domain [IPR039008] 0.6305810944708755 1.427295545127964 0.1534947241556155 1.0 0.4322533146100317 8 Q16352,P07197,P08670,Q03252 4 +Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.9207177814029348 1.40222801577424 0.1608471681840086 1.0 0.4408212315611041 2 O15460 1 +RBM3/CIRBP, RNA recognition motif [IPR034278] 0.911256117455134 1.3647712542928714 0.1723249562701703 1.0 0.4535333544482209 2 Q14011 1 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.9210182767624094 1.332231425807537 0.1827841529011968 1.0 0.4697277175561411 3 O15460,Q32P28 2 +B-box-type zinc finger [IPR000315] 0.6209150326797396 1.3309053336770218 0.1832201620285358 1.0 0.4703754561314922 7 P19474,O15164,Q9C037,O15344,Q12899,Q13263 6 +Thioredoxin domain [IPR013766] 0.4570927608022433 1.308644763078573 0.1906547105347684 1.0 0.4807732690704171 24 P30101,Q96JJ7,Q8NBS9,Q13162,P07237,Q6ZRP7,Q15084,Q9H3N1,O43396,Q8IXB1,O95881,P13667 12 +Zinc finger, CCHC-type [IPR001878] 0.6139826968708267 1.2992017142602406 0.1938747133660914 1.0 0.483697848016133 7 Q9NUD5,Q16629,Q9BWF3 3 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.6443005651635574 1.2990937178432898 0.1939117687740106 1.0 0.483697848016133 6 O15460,Q32P28 2 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.6443005651635574 1.2990937178432898 0.1939117687740106 1.0 0.483697848016133 6 O15460,Q32P28 2 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.6442051057685698 1.2986772766902208 0.1940547054986492 1.0 0.483697848016133 6 P09960,P55786 2 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.6442051057685698 1.2986772766902208 0.1940547054986492 1.0 0.483697848016133 6 P09960,P55786 2 +Alcohol dehydrogenase, N-terminal [IPR013154] 0.641605530442612 1.2873353803340462 0.1979774168155161 1.0 0.4872554272298992 6 Q8N4Q0 1 +Amine oxidase [IPR002937] 0.8773082488222319 1.1756970217438438 0.2397159691770385 1.0 0.541957323771607 3 P50336 1 +CID domain [IPR006569] 0.6128074025028742 1.161622352214286 0.2453888985513881 1.0 0.5468045799422491 6 O95104,Q9NQG5 2 +GOLD domain [IPR009038] 0.6123151159783435 1.1594739598458614 0.2462630449000711 1.0 0.5475605267908538 6 P49755 1 +DZF domain [IPR006561] 0.7081376307258831 1.1553461708647217 0.2479486957776613 1.0 0.5484470718888236 4 Q96SI9 1 +LEM domain [IPR003887] 0.6063336213557593 1.1333771016769072 0.2570559258642628 1.0 0.5584469009642482 6 Q86XL3 1 +LRRC8, pannexin-like TM region [IPR021040] 0.847960848287105 1.1159775932606213 0.2644317258917794 1.0 0.5620547989237573 2 Q8TDW0 1 +Zinc finger, GATA-type [IPR000679] 0.6766370486816868 1.0326953712934854 0.3017464803562812 1.0 0.6017086558129233 4 Q8WXI9,Q86YP4 2 +Exoribonuclease, phosphorolytic domain 2 [IPR015847] 0.6761417658571539 1.0307758018424735 0.3026459683383034 1.0 0.6017086558129233 4 Q9NQT4 1 +SANT domain [IPR017884] 0.5355781124472621 1.0288777790906982 0.3035371114320304 1.0 0.6017086558129233 9 Q8TAQ2,Q96KC8,Q13330,Q99543 4 +ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661] 0.8254486133768306 1.0288280413380164 0.303560487289273 1.0 0.6017086558129233 2 Q969S3 1 +DnaJ domain [IPR001623] 0.4519212911214202 1.0036157120443012 0.3155638783036809 1.0 0.6124676462605608 16 Q96EY1,Q13217,O14976,Q99543,Q8IXB1 5 +Zinc finger, RanBP2-type [IPR001876] 0.5366888338536768 0.9886685022615356 0.3228253583603018 1.0 0.6211169611191059 8 Q01844,P35637,P98175,Q92804 4 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.8188575383220927 0.9691935077491438 0.3324486497072469 1.0 0.6282861768672805 3 Q5BKZ1 1 +Ribosome receptor lysine/proline rich [IPR007794] 0.8052202283849901 0.9514786581991788 0.3413614473378514 1.0 0.6343468174730277 2 Q86UP2 1 +NOPS [IPR012975] 0.8093994778067892 0.936294566120872 0.3491215451374656 1.0 0.6408498140104089 3 Q8WXF1,Q15233 2 +Stromalin conservative domain [IPR020839] 0.7924959216965641 0.903398558482452 0.366314404787015 1.0 0.6499498693330144 2 Q8WVM7 1 +STAG [IPR013721] 0.7924959216965641 0.903398558482452 0.366314404787015 1.0 0.6499498693330144 2 Q8WVM7 1 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7895595432300152 0.8923747614702541 0.3721920942710692 1.0 0.6558953863949785 2 Q92945 1 +Zinc finger, CW-type [IPR011124] 0.7889070146818822 0.8899288838421529 0.3735040734453734 1.0 0.6558953863949785 2 Q8NB78 1 +Endonuclease/exonuclease/phosphatase [IPR005135] 0.7957763869563245 0.8892527372695787 0.3738672658064192 1.0 0.6558953863949785 3 Q6L8Q7 1 +Metallo-beta-lactamase [IPR001279] 0.5753561723192444 0.8851172155995358 0.3760934152466484 1.0 0.6576189595790559 5 Q68D91 1 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.5731670888239544 0.876199541267322 0.3809215658738092 1.0 0.6604889935379482 5 P16615,P35670,Q9HD20 3 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.7830342577487739 0.8679811063848968 0.3854046758393923 1.0 0.663138991421401 2 Q9NVI7 1 +Zinc finger, CHHC-type [IPR012996] 0.7872062663185413 0.8598925075532878 0.3898482990018896 1.0 0.6678204152965839 3 P52597,P55795 2 +Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219] 0.5079213291225296 0.855597893037811 0.3922202357848898 1.0 0.6697911827359944 8 P17252,Q9H0H5 2 +Alpha/beta hydrolase fold-1 [IPR000073] 0.5065169184257974 0.84915237255249 0.3957965112344292 1.0 0.6736908727794118 8 P07099,Q9NUJ1 2 +Protein kinase, C-terminal [IPR017892] 0.5127310808473537 0.8377137931705371 0.4021914648999352 1.0 0.6803321411449362 7 P51812,Q15418,P17252 3 +SWIRM domain [IPR007526] 0.6255397185359631 0.837060300397078 0.402558674052518 1.0 0.6803321411449362 4 Q8TAQ2,Q8NB78 2 +Immunoglobulin C1-set [IPR003597] 0.6236622051577848 0.8299916212075782 0.406543520949377 1.0 0.681149098042776 4 P04439 1 +Matrin/U1-C-like, C2H2-type zinc finger [IPR003604] 0.5010128323724946 0.8239492600945604 0.409968389048994 1.0 0.6838155060654127 8 Q96KR1,Q5VUA4,Q969S3 3 +B-box, C-terminal [IPR003649] 0.620306888671243 0.8173859655671792 0.4137078934418832 1.0 0.6880231325635084 4 O15344,O15164,Q13263 3 +PWI domain [IPR002483] 0.5536738858375676 0.7973968288049385 0.4252206004385788 1.0 0.696533680539043 5 Q9P2N5 1 +AMP-binding enzyme, C-terminal domain [IPR025110] 0.5504843067469598 0.7846199615243722 0.4326764228052611 1.0 0.6997988286944876 5 P33121 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.4186896243089379 0.7844588777829281 0.4327709022183068 1.0 0.6997988286944876 14 Q14011 1 +Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906] 0.7595432300163059 0.7814839472797502 0.4345179145094344 1.0 0.6997988286944876 2 Q15418 1 +AMP-dependent synthetase/ligase [IPR000873] 0.4997485309471545 0.7798176179608532 0.435498234709994 1.0 0.6997988286944876 7 P33121 1 +Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346] 0.7556280587275628 0.7672909860723821 0.4429085265371839 1.0 0.702118476351878 2 Q8WXI9 1 +Brdt, bromodomain, repeat II [IPR043509] 0.7494290375203784 0.7449628369426874 0.4562941863809333 1.0 0.7104639653463732 2 P25440 1 +NET domain [IPR027353] 0.7494290375203784 0.7449628369426874 0.4562941863809333 1.0 0.7104639653463732 2 P25440 1 +Brdt, bromodomain, repeat I [IPR043508] 0.7494290375203784 0.7449628369426874 0.4562941863809333 1.0 0.7104639653463732 2 P25440 1 +Myosin head, motor domain [IPR001609] 0.4833073339156646 0.7436026555574524 0.4571168962015179 1.0 0.7104639653463732 8 P35580,Q9Y4I1,Q7Z406,O00159 4 +NAD-dependent epimerase/dehydratase [IPR001509] 0.7507754127129346 0.7375274966417672 0.4608016281613034 1.0 0.7144290600166634 3 Q9NRG7 1 +S1-like RNA binding domain [IPR025223] 0.7422512234910275 0.7193410070610186 0.4719308354157463 1.0 0.721357087638411 2 Q8N163 1 +DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954] 0.7422512234910275 0.7193410070610186 0.4719308354157463 1.0 0.721357087638411 2 Q8N163 1 +BURAN domain [IPR045354] 0.7422512234910275 0.7193410070610186 0.4719308354157463 1.0 0.721357087638411 2 Q8N163 1 +LAIKA domain [IPR045353] 0.7422512234910275 0.7193410070610186 0.4719308354157463 1.0 0.721357087638411 2 Q8N163 1 +Domain of unknown function DUF1605 [IPR011709] 0.4427658876742943 0.7081245230337075 0.478867932019376 1.0 0.7261377239335826 11 Q7Z478,Q8IX18,Q8IY37 3 +Helicase-associated domain [IPR007502] 0.4427658876742943 0.7081245230337075 0.478867932019376 1.0 0.7261377239335826 11 Q7Z478,Q8IX18,Q8IY37 3 +Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585] 0.7367047308319719 0.6997219740962419 0.4841009507047689 1.0 0.7275987151298663 2 Q13243 1 +Myosin, N-terminal, SH3-like [IPR004009] 0.5280982606645565 0.6960824098715341 0.4863772217223867 1.0 0.7291334379161334 5 Q9Y4I1,Q7Z406,P35580 3 +Zinc finger, LIM-type [IPR001781] 0.4398571378928209 0.6938678950142787 0.487765059060828 1.0 0.7297924259909521 11 Q96HC4,Q93052,Q14847,Q9UHB6 4 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.7321370309950956 0.6836883990893567 0.4941719505348028 1.0 0.7342229387085942 2 Q16836 1 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.7321370309950956 0.6836883990893567 0.4941719505348028 1.0 0.7342229387085942 2 Q16836 1 +Matrin/U1-C, C2H2-type zinc finger [IPR000690] 0.5154116900136168 0.6469423099852343 0.5176692813017079 1.0 0.7542338189677874 5 Q14966,Q15428 2 +MIRO domain [IPR020860] 0.7135399673735705 0.6196492251987807 0.5354887509241948 1.0 0.761753248927242 2 Q8IXI2 1 +EF hand associated, type-1 [IPR013566] 0.7135399673735705 0.6196492251987807 0.5354887509241948 1.0 0.761753248927242 2 Q8IXI2 1 +EF hand associated, type-2 [IPR013567] 0.7135399673735705 0.6196492251987807 0.5354887509241948 1.0 0.761753248927242 2 Q8IXI2 1 +Zinc finger, CCCH-type [IPR000571] 0.4097533453643524 0.6025642286639624 0.5467986231650459 1.0 0.7682220216664958 12 Q86VM9 1 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.7061233947878158 0.5946056329153929 0.5521071139042415 1.0 0.774403669913958 3 Q96EY1 1 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.5587310761653983 0.5940193974831861 0.5524991392226846 1.0 0.7745286726932041 4 Q9UKA9 1 +Lamin tail domain [IPR001322] 0.7013707571801684 0.5799652241913932 0.5619380694440175 1.0 0.783038497857413 3 P20700,Q03252 2 +Band 7 domain [IPR001107] 0.4433701316784642 0.568121054126573 0.5699527724802462 1.0 0.7868929806417456 8 O75955,Q9UJZ1,P27105,O75477 4 +La-type HTH domain [IPR006630] 0.4924437802597384 0.560352257968386 0.5752391892067876 1.0 0.7873660092977872 5 Q92615 1 +Plectin/S10, N-terminal [IPR005326] 0.6955954323001576 0.5599506062788758 0.5755131292051483 1.0 0.7873660092977872 2 P46783 1 +Zinc finger, MYND-type [IPR002893] 0.6923327895595384 0.5493388552970433 0.582772927027698 1.0 0.7951967493118991 2 O94966 1 +Target SNARE coiled-coil homology domain [IPR000727] 0.4309721802533786 0.5466885515697506 0.5845927207959238 1.0 0.7951967493118991 9 P56962,O15400,Q86Y82 3 +CELF1/2, RNA recognition motif 3 [IPR034199] 0.6884176182707955 0.5367089363595469 0.5914686822677349 1.0 0.7970324959057956 2 Q92879 1 +CELF1/2, RNA recognition motif 1 [IPR034196] 0.6884176182707955 0.5367089363595469 0.5914686822677349 1.0 0.7970324959057956 2 Q92879 1 +CELF1/2, RNA recognition motif 2 [IPR034198] 0.6884176182707955 0.5367089363595469 0.5914686822677349 1.0 0.7970324959057956 2 Q92879 1 +Myosin tail [IPR002928] 0.6840731070496135 0.527766517755227 0.5976613988098085 1.0 0.7992309003104197 3 Q7Z406,P35580 2 +Myb domain [IPR017930] 0.4325674298802394 0.5225243305687796 0.6013053106030715 1.0 0.8012181757228003 8 Q8TAQ2,Q99459,Q96KC8,Q99543 4 +Tim44-like domain [IPR007379] 0.6809135399673696 0.5128294926400233 0.6080705974327061 1.0 0.8047808062295183 2 O43615 1 +Aminoacyl-tRNA synthetase, class Ia [IPR002300] 0.456979245343627 0.50864702346371 0.6109996619909666 1.0 0.8060416888236211 6 Q9NSE4 1 +Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155] 0.456979245343627 0.50864702346371 0.6109996619909666 1.0 0.8060416888236211 6 Q9NSE4 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.6750407830342533 0.4944529280067079 0.6209863423451112 1.0 0.8101073639578805 2 O43390 1 +Chromo domain subgroup [IPR017984] 0.6710182767624207 0.4895903265366728 0.6244238230037662 1.0 0.8125454022496846 3 P45973,Q13185 2 +Chromo shadow domain [IPR008251] 0.6710182767624207 0.4895903265366728 0.6244238230037662 1.0 0.8125454022496846 3 P45973,Q13185 2 +Zinc finger C2H2-type [IPR013087] 0.3443832322692808 0.4717961733509923 0.6370722825556265 1.0 0.8203336882730904 22 Q9Y2X9,Q96JM3,Q96ME7,Q14966,Q92766,Q92785,Q9H2P0,Q969S3,Q9NRM2,Q96KR1,P98175 11 +U-box domain [IPR003613] 0.4453102329969703 0.4647911035150839 0.6420810593596487 1.0 0.8215147604781193 6 Q7Z6E9,Q14139 2 +3'-5' exonuclease domain [IPR002562] 0.6652528548123927 0.4644625452050922 0.6423163882165135 1.0 0.8215147604781193 2 Q01780 1 +Exosome complex component, N-terminal domain [IPR025721] 0.6642740619902 0.4615087484799954 0.6444336462591864 1.0 0.8221460989469522 2 Q13868 1 +EGF-like domain [IPR000742] 0.6605744125326527 0.4598706128252371 0.645609094865875 1.0 0.8221460989469522 3 P07942,Q07954 2 +B30.2/SPRY domain [IPR001870] 0.3886521680806763 0.4540640040404323 0.6497827604635873 1.0 0.8225220388640557 11 P19474,Q9BUJ2,Q96S59,Q12899 4 +SPRY domain [IPR003877] 0.3886521680806763 0.4540640040404323 0.6497827604635873 1.0 0.8225220388640557 11 P19474,Q9BUJ2,Q96S59,Q12899 4 +FF domain [IPR002713] 0.6610114192495866 0.4517237476205342 0.6514680081351587 1.0 0.8230255418980241 2 O75400 1 +EGF-like calcium-binding domain [IPR001881] 0.660358890701463 0.4497781081461503 0.6528704445548263 1.0 0.8235765795395614 2 Q07954 1 +G-patch domain [IPR000467] 0.3525249984572206 0.4341078883070968 0.6642100974956098 1.0 0.8264403313074972 14 P18583,P78332,Q8IWZ8,Q96I25,P98175 5 +CARG-binding factor, N-terminal [IPR012956] 0.6482871125611613 0.4144865958830784 0.6785177816128134 1.0 0.835346030950238 2 Q99729 1 +Pentacotripeptide-repeat region of PRORP [IPR033443] 0.643066884176174 0.3996512975886031 0.6894133680586008 1.0 0.8410448388004973 2 O75127 1 +S100/CaBP-9k-type, calcium binding, subdomain [IPR013787] 0.6398042414355518 0.3905142697832405 0.6961563055257387 1.0 0.843063874065486 2 P31949 1 +EF-hand, Ca insensitive [IPR014837] 0.6331592689295105 0.3856817480411084 0.6997323819189623 1.0 0.8431518180633727 3 O43707,Q13813 2 +Double-stranded RNA-binding domain [IPR014720] 0.3382915163466445 0.366478043209283 0.7140083937056061 1.0 0.8468232831780668 14 O95793,Q96SI9,O75569,Q9NXV6 4 +SLIDE domain [IPR015195] 0.630995106035881 0.3663771330663944 0.7140836804818271 1.0 0.8468232831780668 2 P28370 1 +ISWI, HAND domain [IPR015194] 0.630995106035881 0.3663771330663944 0.7140836804818271 1.0 0.8468232831780668 2 P28370 1 +Saposin B type domain [IPR008139] 0.630016313213696 0.3637441638109806 0.7160490611725328 1.0 0.8479125687925408 2 Q9Y2B0 1 +Bromo adjacent homology (BAH) domain [IPR001025] 0.4840592174182082 0.355283644595475 0.7223771069933402 1.0 0.8507634212756198 4 Q13330 1 +RecF/RecN/SMC, N-terminal [IPR003395] 0.4323091578038917 0.3535800357809241 0.7236536382071794 1.0 0.8509707950224324 5 Q9UQE7,Q8IY18,Q14683 3 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.6178065452158072 0.3467846464101974 0.7287531125874804 1.0 0.8547601687315893 3 Q99797 1 +Class II aldolase/adducin N-terminal [IPR001303] 0.6202283849918344 0.3379676282008447 0.7353875828156511 1.0 0.8547863903624022 2 P35611 1 +RING-type zinc-finger, LisH dimerisation motif [IPR027370] 0.6199021207177724 0.3371259867478994 0.7360219283375964 1.0 0.8547863903624022 2 O15344 1 +SANT/Myb domain [IPR001005] 0.351675260336281 0.3362512203700962 0.736681430905006 1.0 0.8547863903624022 12 Q8TAQ2,Q99459,Q99543,Q13330,Q96KC8 5 +Exonuclease, RNase T/DNA polymerase III [IPR013520] 0.6098801601817052 0.3275062747337902 0.743284997869903 1.0 0.8554445562930074 3 Q9Y3B8 1 +AARP2CN [IPR012948] 0.6114192495921602 0.3156506562813417 0.7522676837017355 1.0 0.8564329773932936 2 Q2NL82 1 +Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034] 0.6114192495921602 0.3156506562813417 0.7522676837017355 1.0 0.8564329773932936 2 Q2NL82 1 +Bms1/Tsr1-type G domain [IPR030387] 0.6114192495921602 0.3156506562813417 0.7522676837017355 1.0 0.8564329773932936 2 Q2NL82 1 +SPRY-associated [IPR006574] 0.4595808009219859 0.2883877536456982 0.7730499408992801 1.0 0.8652151694749205 4 P19474,Q12899 2 +TRASH domain [IPR011017] 0.592615579168772 0.2875130553583662 0.7737195070141158 1.0 0.8652151694749205 3 Q9UBW7 1 +Glycosyl transferase, family 1 [IPR001296] 0.5993474714518654 0.2864745454208116 0.7745146866910186 1.0 0.8652151694749205 2 Q9BT22 1 +Butyrophylin-like, SPRY domain [IPR003879] 0.4098819813937194 0.2862730768180797 0.7746689771953994 1.0 0.8652151694749205 5 P19474,O15344,Q12899 3 +Histone H2A/H2B/H3 [IPR007125] 0.457257010816672 0.2823898611263264 0.777644588429204 1.0 0.8660440821487259 4 P84243 1 +SAP domain [IPR003034] 0.3168853060290374 0.2723635468205141 0.7853424989451638 1.0 0.8739373300670402 14 P82979,Q9BUJ2,O75928,Q8IX12,P12956 5 +Chaperone DnaJ, C-terminal [IPR002939] 0.4519942438690896 0.2690435471367235 0.7878961719178337 1.0 0.8742113854130346 4 Q96EY1 1 +Kinesin motor domain [IPR001752] 0.3393525832511516 0.2540177390061765 0.7994818537351294 1.0 0.8819133304576039 11 O00139,O95239,P33176,Q99661,Q8NI77 5 +DEAD/DEAH box helicase domain [IPR011545] 0.3067847130906476 0.2498639630080551 0.8026925527577562 1.0 0.8840252649633561 44 Q92841,P17844,Q9Y2R4,Q15477,Q7Z478,Q86XP3,Q9UHI6,Q8N8A6,Q7L014,Q8IY37,O00148,Q8IX18,P38919,Q9NUL7,Q8TDD1,Q8NHQ9,Q9Y6V7,Q9H2U1,Q13206 19 +Forkhead-associated (FHA) domain [IPR000253] 0.3533758656020366 0.2450358088606455 0.8064287049007395 1.0 0.8872797755728016 9 P85037 1 +TATA box binding protein associated factor (TAF) [IPR004823] 0.5758564437194021 0.2345614850898505 0.814549106009703 1.0 0.8939064652647255 2 Q9Y6J9 1 +AGC-kinase, C-terminal [IPR000961] 0.3410053209801708 0.2300022577238138 0.8180900153359649 1.0 0.896253714316222 10 P17252,Q13464 2 +Clp ATPase, C-terminal [IPR019489] 0.5693311582381602 0.2213167747333639 0.8248457894649115 1.0 0.9017232508173488 2 O76031 1 +OCRE domain [IPR041591] 0.5602944305231623 0.2204663525770437 0.8255079744548737 1.0 0.9020614917440648 3 P98175 1 +Serine/threonine-protein kinase N, C2 domain [IPR037784] 0.567373572593788 0.2174447530164533 0.827861757558547 1.0 0.9035331592917192 2 Q16512 1 +Serine/threonine-protein kinase N, first HR1 domain [IPR037313] 0.567373572593788 0.2174447530164533 0.827861757558547 1.0 0.9035331592917192 2 Q16512 1 +Domain of unknown function DUF4217 [IPR025313] 0.5560084972709346 0.2123767671371308 0.8318131095055246 1.0 0.90624035833218 3 Q13206 1 +IPT domain [IPR002909] 0.5537144473642144 0.208125755219353 0.8351307776968744 1.0 0.909467375881988 3 Q96KP1 1 +K Homology domain, type 1 [IPR004088] 0.2929460499124351 0.2045703684504185 0.8379078083177625 1.0 0.9121031357464958 23 P61978,Q96AE4,O75525,Q13868,P51116,Q92945,Q96I24,Q92667 8 +Sec63 domain [IPR004179] 0.5453655352480365 0.1931224363730826 0.8468630817212102 1.0 0.9195027176055772 3 O75643,Q9UGP8 2 +VHS domain [IPR002014] 0.4182360261538264 0.1916711881720293 0.8479997760182831 1.0 0.920075962323086 4 Q92783 1 +Zinc finger, double-stranded RNA binding [IPR022755] 0.4179457951373456 0.191070295263437 0.848470519811434 1.0 0.920075962323086 4 Q969S3 1 +Staufen, C-terminal [IPR032478] 0.535831643467257 0.1768929950158235 0.8595924410213438 1.0 0.9295686396751396 3 O95793 1 +CAP Gly-rich domain [IPR000938] 0.5352912112466139 0.1760019953123264 0.860292374885447 1.0 0.9295686396751396 3 Q99426 1 +RNA helicase, DEAD-box type, Q motif [IPR014014] 0.2858267202211447 0.1749230107809695 0.8611401290423231 1.0 0.9296993403033872 25 Q7L014,P38919,Q92841,P17844,Q9Y2R4,Q9NUL7,Q13206,Q8TDD1,Q8NHQ9,Q86XP3,Q9Y6V7,O00148,Q9UHI6 13 +BTB/POZ domain [IPR000210] 0.5438825448613229 0.1746630011600083 0.8613444416029425 1.0 0.9296993403033872 2 Q08380 1 +14-3-3 domain [IPR023410] 0.3511924207775224 0.1695940073191553 0.8653294357436558 1.0 0.931660969459862 6 P62258,Q04917,P63104,P61981,P31946 5 +SMCs flexible hinge [IPR010935] 0.3574138645737312 0.1559084678115015 0.876105170586194 1.0 0.9412608912558394 5 Q9UQE7,Q9NTJ3,Q14683 3 +WSTF/Acf1/Cbp146 [IPR013136] 0.5210440456769818 0.139587610420533 0.8889858302275089 1.0 0.9507054654503304 2 Q9NRL2 1 +Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.5052219321148779 0.1313285193219463 0.8955154320098766 1.0 0.9552272644056256 3 P11940,O95071 2 +R3H domain [IPR001374] 0.5029373368146177 0.1283255679731745 0.8978913320627195 1.0 0.9566283900351558 3 O15226,O95453 2 +SNF2, N-terminal [IPR000330] 0.2781457206491616 0.1201637456813592 0.9043534363854926 1.0 0.9619100402819072 17 P46100 1 +PABP, RNA recognition motif 2 [IPR045305] 0.5050570962479479 0.1187779667532075 0.9054512650748424 1.0 0.9620587797499426 2 P11940 1 +YTH domain [IPR007275] 0.5027732463295175 0.1160495978943824 0.9076132338711986 1.0 0.9629738751073256 2 Q96MU7 1 +Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346] 0.490701468189224 0.1026124031286054 0.9182705985332936 1.0 0.970825652143778 2 Q93009 1 +Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615] 0.490701468189215 0.1026124031285959 0.9182705985333012 1.0 0.970825652143778 2 Q86UV5 1 +SLC12A transporter, C-terminal [IPR018491] 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 0.970825652143778 2 Q9Y666 1 +Amino acid permease/ SLC12A domain [IPR004841] 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 0.970825652143778 2 Q9Y666 1 +Kinesin-like [IPR022164] 0.4815660685154813 0.0935118050191747 0.9254969717405016 1.0 0.9765005320417354 2 Q9Y3P9 1 +Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730] 0.4776508972267335 0.089883196983559 0.9283800339630146 1.0 0.9789145347807952 2 P38117 1 +Ribosomal protein L18e/L15P [IPR021131] 0.4663971746765928 0.0875371596532533 0.9302445496505208 1.0 0.9800722346338614 3 Q07020 1 +Dehydrogenase, E1 component [IPR001017] 0.4605091383811958 0.0821882233888838 0.9344970381363236 1.0 0.9837418388285628 3 Q02218,P12694 2 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.456266318537854 0.0785328616577134 0.9374041911107628 1.0 0.985584916394005 3 P20020,P16615 2 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.456266318537854 0.0785328616577134 0.9374041911107628 1.0 0.985584916394005 3 P20020,P16615 2 +EF-hand domain [IPR002048] 0.2779587477656594 0.0762307601290942 0.9392355108380316 1.0 0.9866989322978004 41 Q9Y680,Q14257,P80303,Q9NWM8,O43852 5 +Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378] 0.3080312228692804 0.0722931058692187 0.9423686510618764 1.0 0.9875560003136138 5 Q8NC60 1 +Serine-tRNA ligase catalytic core domain [IPR033729] 0.4525285481239748 0.070225949081842 0.944013820927284 1.0 0.9885542334245606 2 Q9NP81 1 +RasGAP protein, C-terminal [IPR000593] 0.4508972267536623 0.0691532482219961 0.944867636484015 1.0 0.9885542334245606 2 Q13576 1 +HTH CenpB-type DNA-binding domain [IPR006600] 0.4486133768352142 0.0676905000332872 0.9460320118417408 1.0 0.988963145657944 2 P07199 1 +DDE superfamily endonuclease domain [IPR004875] 0.4486133768352142 0.0676905000332872 0.9460320118417408 1.0 0.988963145657944 2 P07199 1 +Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630] 0.4363577023498701 0.0635034296234879 0.9493656283136912 1.0 0.9899779137792796 3 Q6UB35,P13995 2 +Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631] 0.4363577023498701 0.0635034296234879 0.9493656283136912 1.0 0.9899779137792796 3 Q6UB35,P13995 2 +Class I myosin tail homology domain [IPR010926] 0.4357049608355097 0.0630673474977799 0.9497128754401928 1.0 0.9899779137792796 3 O94832,O00159 2 +Class I myosin, motor domain [IPR036072] 0.4357049608355097 0.0630673474977799 0.9497128754401928 1.0 0.9899779137792796 3 O94832,O00159 2 +SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678] 0.42656657963447 0.0573182313071657 0.9542916977443604 1.0 0.9927549113231466 3 P46087,Q08J23 2 +ELM2 domain [IPR000949] 0.4246083550913907 0.0561705328701298 0.95520595545155 1.0 0.9927549113231466 3 Q13330,O94776 2 +Suppressor of forked [IPR008847] 0.4225122349102687 0.0539607951148337 0.9569663996744322 1.0 0.9927549113231466 2 Q14690 1 +RNA polymerase, N-terminal [IPR006592] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 0.9927549113231466 3 P24928,O14802 2 +RNA polymerase, alpha subunit [IPR000722] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 0.9927549113231466 3 P24928,O14802 2 +RNA polymerase Rpb1, domain 5 [IPR007081] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 0.9927549113231466 3 P24928,O14802 2 +RNA polymerase Rpb1, domain 3 [IPR007066] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 0.9927549113231466 3 P24928,O14802 2 +RNA polymerase Rpb1, domain 4 [IPR007083] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 0.9927549113231466 3 P24928,O14802 2 +RNA polymerase Rpb1, domain 1 [IPR007080] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 0.9927549113231466 3 P24928,O14802 2 +Ribosomal protein S4/S9, N-terminal [IPR001912] 0.4153344208809107 0.0510520852995186 0.9592840165596754 1.0 0.9936793301740934 2 Q9NV31 1 +DNA mismatch repair protein MutS, clamp [IPR007861] 0.4146818923327835 0.0508042206256163 0.9594815276495254 1.0 0.9936793301740934 2 P52701 1 +SUN domain [IPR012919] 0.4073107049608391 0.0472393286110139 0.9623224827962196 1.0 0.995412050368096 3 O94901,Q9UH99 2 +MIF4G-like, type 3 [IPR003890] 0.2785223929388651 0.0451763997135537 0.9639667053403532 1.0 0.9954327899548274 8 O43432,Q9H074,Q5C9Z4,A9UHW6,Q04637,Q09161,Q9HAU5 7 +Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394] 0.2523123115289673 0.0446864807267567 0.964357209751194 1.0 0.9954327899548274 13 Q9P275,Q96K76,Q96RU2 3 +Ubiquitin specific protease domain [IPR028889] 0.2523123115289673 0.0446864807267567 0.964357209751194 1.0 0.9954327899548274 13 Q9P275,Q96K76,Q96RU2 3 +PPM-type phosphatase domain [IPR001932] 0.3035537893320391 0.0412391223045234 0.9671052650981852 1.0 0.9956138482214704 4 Q15750 1 +GCF, C-terminal [IPR022783] 0.3797716150081503 0.0409746112091489 0.9673161361791592 1.0 0.9956138482214704 2 Q9UBB9 1 +Spt5 C-terminal domain [IPR024945] 0.3546492659053842 0.0371123946736214 0.9703953893170496 1.0 0.9956138482214704 2 Q9UQ35 1 +Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598] 0.3448613376835243 0.0361117728409099 0.97119323508202 1.0 0.9956138482214704 2 Q9UNQ2 1 +RNA polymerase Rpb2, domain 7 [IPR007641] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 0.9956138482214704 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 2 [IPR007642] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 0.9956138482214704 2 Q9H9Y6 1 +RNA polymerase, beta subunit, protrusion [IPR007644] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 0.9956138482214704 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 3 [IPR007645] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 0.9956138482214704 2 Q9H9Y6 1 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 0.9956138482214704 2 Q9H9Y6 1 +Ku70/Ku80 C-terminal arm [IPR005160] 0.3233278955954338 0.0346152265514435 0.9723865597440332 1.0 0.9956138482214704 2 P12956 1 +Ku70/Ku80, N-terminal alpha/beta [IPR005161] 0.3233278955954338 0.0346152265514435 0.9723865597440332 1.0 0.9956138482214704 2 P12956 1 +Ku70/Ku80 beta-barrel domain [IPR006164] 0.3233278955954338 0.0346152265514435 0.9723865597440332 1.0 0.9956138482214704 2 P12956 1 +Transketolase, C-terminal domain [IPR033248] 0.2786296900489415 0.0333562205518131 0.973390521156896 1.0 0.9956138482214704 2 P11177 1 +Immunoglobulin subtype 2 [IPR003598] 0.2721640716057286 0.0318449736417086 0.9745956810279048 1.0 0.9964178953971822 7 Q13308,P10586,Q13740,Q9BX67 4 +Histone H2A, C-terminal domain [IPR032454] 0.327023498694522 0.0269440089217465 0.9785043922021864 1.0 0.9990076489114912 3 P16104,O75367 2 +SCP2 sterol-binding domain [IPR003033] 0.3247389033942601 0.0267094221146743 0.97869149805369 1.0 0.9990076489114912 3 Q6YN16,P51659 2 +Immunoglobulin I-set [IPR013098] 0.318864229765018 0.0261603522785915 0.9791294393490656 1.0 0.999055856510599 3 Q13308,P10586 2 +Small-subunit processome, Utp12 [IPR007148] 0.2826370757180208 0.0240984010204986 0.9807741187541132 1.0 0.999637575396372 3 Q15061,Q15269 2 +Transketolase-like, pyrimidine-binding domain [IPR005475] 0.2787206266318619 0.0239752127350053 0.9808723803947974 1.0 0.999637575396372 3 Q02218,P11177 2 +SH3 domain [IPR001452] 0.2637537716749451 0.0215331300976171 0.9828203755886492 1.0 1.0 36 P07948,O00459,O14936,Q92796,Q8N5V2,Q14168,Q9UQB8,Q92783,Q5T2T1 9 +Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245] 0.2375040836328012 0.001562037133124 0.99875367519491 1.0 1.0 6 P07948,Q13308,Q15375,P41240,Q9UHY1 5 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9e427c1ad7d22095aacdf4c918e4c93e8f4915f7 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3'5'-cyclic nucleotide phosphodiesterase, catalytic domain [IPR002073]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-3' exoribonuclease 1, SH3-like domain [IPR041385]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADD domain [IPR025766]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APPL1, BAR domain [IPR037929]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "ATRX, ADD domain [IPR041430]", "AWS domain [IPR006560]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adenomatous polyposis coli protein basic domain [IPR009234]", "Adenomatous polyposis coli, N-terminal dimerisation domain [IPR032038]", "Adenosine deaminase domain [IPR001365]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanine racemase, N-terminal [IPR001608]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-dystroglycan N-terminal domain 2 [IPR041631]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 2, C-terminal [IPR014786]", "Anaphase-promoting complex subunit 4 long domain [IPR024790]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora-A binding [IPR015128]", "B(0)AT2, solute-binding domain [IPR042934]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BCAS3 domain [IPR022175]", "BCNT-C domain [IPR011421]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BR140-related, PWWD domain [IPR035502]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BRPF2, PHD domain [IPR042009]", "BRPF2, ePHD domain [IPR042004]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Bcr-Abl oncoprotein oligomerisation [IPR015123]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCDC93, coiled-coil domain [IPR019159]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMPASS complex Set1 subunit, N-SET domain [IPR024657]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPPED1, metallophosphatase domain [IPR041867]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-binding protein cabin-1, MEF2-binding domain [IPR015134]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carbohydrate kinase, FGGY, N-terminal [IPR018484]", "Carbon-nitrogen hydrolase [IPR003010]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein CENP-B, C-terminal domain [IPR015115]", "Centromere protein Cenp-F, N-terminal [IPR018463]", "Centromere protein Cenp-F, leucine-rich repeat-containing domain [IPR019513]", "Centrosomin, N-terminal motif 1 [IPR012943]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class V myosin, motor domain [IPR036103]", "Class VI myosin, motor domain [IPR036114]", "Classical Protein Kinase C alpha, catalytic domain [IPR034663]", "Classical protein kinase C beta, catalytic domain [IPR034664]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Conserved oligomeric Golgi complex, subunit 4 [IPR013167]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-dependent kinase 11/PITSLRE, catalytic domain [IPR045267]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b-c1 complex subunit Rieske, transmembrane domain [IPR004192]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-glucuronyl C5-epimerase, C-terminal [IPR010598]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAMP1, SANT/Myb-like domain [IPR032563]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DG-type SEA domain [IPR030398]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA binding HTH domain, Psq-type [IPR007889]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA methyltransferase 1-associated 1 [IPR008468]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha, subunit B, N-terminal [IPR013627]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase epsilon subunit B, N-terminal [IPR024639]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor Dna2, N-terminal [IPR014808]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding RFX-type winged-helix domain [IPR003150]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DUS-like, FMN-binding domain [IPR035587]", "DUS2, double-stranded RNA binding domain [IPR044463]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Daxx, N-terminal Rassf1C-interacting domain [IPR031333]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dedicator of cytokinesis, N-terminal domain [IPR032376]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disks Large homologue 3, SH3 domain [IPR035763]", "Disks large homologue 1, N-terminal PEST domain [IPR019590]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF1977, DnaJ-like [IPR015399]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5595 [IPR040967]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "Dystroglycan, C-terminal [IPR008465]", "Dystroglycan-type cadherin-like [IPR006644]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB-1 binding [IPR009232]", "EB1, C-terminal [IPR004953]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enhancer of polycomb-like, N-terminal [IPR019542]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephexin-1, SH3 domain [IPR035635]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin receptor-binding domain [IPR001799]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Ephrin-B ectodomain [IPR034255]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exocyst component Exo84, C-terminal [IPR032403]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease Xrn1, D2/D3 domain [IPR041106]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain [IPR002938]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM3C (ILEI) domain [IPR039475]", "FAM69, protein-kinase domain [IPR022049]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FOXO protein, KIX-binding domain [IPR032068]", "FOXO protein, transactivation domain [IPR032067]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Far11/STRP, C-terminal [IPR021819]", "Far11/STRP, N-terminal [IPR012486]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCF, C-terminal [IPR022783]", "GH15-like domain [IPR011613]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Golgin subfamily A, conserved domain [IPR043976]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase,subfamily IIIA [IPR006549]", "HAT, C-terminal dimerisation domain [IPR008906]", "HAUS augmin-like complex subunit 6, N-terminal [IPR028163]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Heavy metal-associated domain, HMA [IPR006121]", "Heavy metal-associated domain, copper ion-binding [IPR006122]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HhH-GPD domain [IPR003265]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone chaperone domain CHZ [IPR019098]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase complex subunit SAP30 zinc-finger [IPR025717]", "Histone deacetylase complex subunit SAP30, Sin3 binding domain [IPR025718]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Huntingtin-interacting protein 1, clathrin-binding domain [IPR032422]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxyacylglutathione hydrolase, C-terminal domain [IPR032282]", "Hydroxyacylglutathione hydrolase, MBL domain [IPR035680]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "ILEI/PANDER domain [IPR039477]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Initiation factor eIF2 gamma, C-terminal [IPR015256]", "Initiation factor eIF2 gamma, GTP-binding domain [IPR044128]", "Initiation factor eIF2 gamma, domain 2 [IPR044127]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Int12, PHD finger [IPR039054]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain [IPR018302]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "LYRM7, LYR domain [IPR045298]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV type B [IPR013015]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "LysM domain [IPR018392]", "Lysine-specific demethylase 4, Tudor domain [IPR040477]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MPP7, SH3 domain [IPR035599]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTF2, PHD domain 1 [IPR042014]", "MTF2, PHD domain 2 [IPR042015]", "MYND-like zinc finger [IPR031615]", "MYST, zinc finger domain [IPR040706]", "Mab-21 domain [IPR024810]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mff-like domain [IPR039433]", "Mib-herc2 [IPR010606]", "Micro-fibrillar-associated protein 1, C-terminal [IPR009730]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mon2, C-terminal [IPR032817]", "Mon2, dimerisation and cyclophilin-binding domain [IPR032629]", "Morc, S5 domain 2-like [IPR041006]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin 5a, cargo-binding domain [IPR037988]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myosin-binding domain [IPR026859]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH dehydrogenase subunit 5, C-terminal [IPR010934]", "NADH pyrophosphatase-like, N-terminal [IPR015375]", "NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal [IPR001516]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit [IPR001750]", "NADH:ubiquinone oxidoreductase intermediate-associated protein 30 [IPR013857]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NEMO, Zinc finger [IPR034735]", "NET domain [IPR027353]", "NF-kappa-B essential modulator NEMO, CC2-LZ domain [IPR032419]", "NF-kappa-B essential modulator NEMO, N-terminal [IPR021063]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NFkappaB IPT domain [IPR033926]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIF system FeS cluster assembly, NifU, C-terminal [IPR001075]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nas2, N-terminal [IPR040815]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nit1/2, carbon-nitrogen hydrolase domain [IPR045254]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Novel protein kinase C delta, catalytic domain [IPR034667]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear hormone receptor, ligand-binding domain [IPR000536]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Olduvai domain [IPR010630]", "Orc1-like, AAA ATPase domain [IPR041664]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAS domain [IPR000014]", "PAS fold [IPR013767]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PDZ-associated domain of NMDA receptors [IPR019583]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI31 proteasome regulator, C-terminal [IPR013886]", "PI3K p85 subunit, C-terminal SH2 domain [IPR035020]", "PI3K p85 subunit, N-terminal SH2 domain [IPR035022]", "PI3K regulatory subunit p85-related , inter-SH2 domain [IPR032498]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PINIT domain [IPR023321]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PKHA4-7, PH domain [IPR040392]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "PNK, FHA domain [IPR041388]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP2B, metallophosphatase domain [IPR041751]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRELI/MSF1 domain [IPR006797]", "PRKCBP1, PHD finger [IPR044075]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Par3/HAL, N-terminal [IPR021922]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase like 2, U-box domain [IPR026951]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain [IPR035586]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain [IPR045583]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Plus-3 domain [IPR004343]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polycomb-like MTF2 factor 2, C-terminal domain [IPR025894]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polynucleotide 3'-phosphatase [IPR006551]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase A anchor protein, nuclear localisation signal domain [IPR019510]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Putative zinc-finger domain [IPR019607]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "Quinolinate phosphoribosyl transferase, C-terminal [IPR002638]", "Quinolinate phosphoribosyl transferase, N-terminal [IPR022412]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RACK7, Bromo domain [IPR037967]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM6, OCRE domain [IPR035617]", "RBM6, RNA recognition motif 1 [IPR034123]", "RBM6, RNA recognition motif 2 [IPR034125]", "RBM8, RNA recognition motif [IPR033744]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RFX1 transcription activation region [IPR007668]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIO kinase [IPR000687]", "RIO2 kinase winged helix domain, N-terminal [IPR015285]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad4 beta-hairpin domain 1 [IPR018326]", "Rad4 beta-hairpin domain 2 [IPR018327]", "Rad4 beta-hairpin domain 3 [IPR018328]", "Rad4/PNGase transglutaminase-like fold [IPR018325]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Raptor, N-terminal CASPase-like domain [IPR029347]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Rel homology dimerisation domain [IPR032397]", "Rel homology domain (RHD), DNA-binding domain [IPR011539]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Retinoblastoma-associated protein, A-box [IPR002720]", "Retinoblastoma-associated protein, B-box [IPR002719]", "Retinoblastoma-associated protein, C-terminal [IPR015030]", "Retinoblastoma-associated protein, N-terminal [IPR024599]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal RNA-processing protein 7, C-terminal domain [IPR024326]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome recycling factor domain [IPR023584]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Rieske iron-sulphur protein, C-terminal [IPR005805]", "RmlD-like substrate binding domain [IPR029903]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rrp7, RRM-like N-terminal domain [IPR040447]", "Rrp7A, RNA recognition motif [IPR034890]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3PXD2, PX domain [IPR037961]", "SH3PXD2B, SH3 domain 1 [IPR035477]", "SH3PXD2B, SH3 domain 2 [IPR035478]", "SH3PXD2B, SH3 domain 3 [IPR035479]", "SH3PXD2B, SH3 domain 4 [IPR035480]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX2, PX domain [IPR037918]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAR protein, homodimerisation region [IPR032377]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Scaffold protein Nfu/NifU, N-terminal [IPR014824]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sde2, N-terminal ubiquitin domain [IPR024974]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec7, C-terminal [IPR015403]", "Sec8 exocyst complex component specific domain [IPR007191]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase Rio2 [IPR030484]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set1A, RNA recognition motif [IPR034467]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Signal transduction histidine kinase-related protein, C-terminal [IPR004358]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin 4, PX domain [IPR034902]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-4, BAR domain [IPR037430]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Sphingolipid delta4-desaturase, N-terminal [IPR013866]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strawberry notch, AAA domain [IPR039187]", "Strawberry notch, helicase C domain [IPR026937]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromal interaction molecule 1, SAM domain [IPR037609]", "Stromal interaction molecule, Orai1-activating region [IPR032393]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfatase-modifying factor enzyme [IPR005532]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Synaptotagmin-like, mitochondrial and lipid-binding domain [IPR040885]", "Syndetin, C-terminal [IPR019514]", "Synembryn [IPR008376]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "Syntrophin, split Pleckstrin homology (PH) domain [IPR041428]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFA2, Winged helix domain 2 [IPR040501]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRIM4, PRY/SPRY domain [IPR035829]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TUG ubiquitin-like domain [IPR021569]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere repeat-binding factor, dimerisation domain [IPR013867]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Telomeric repeat-binding factor 2, Rap1-binding domain [IPR031902]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tex protein, YqgF-like domain [IPR032639]", "Tex, S1 domain [IPR044146]", "Tex-like protein, N-terminal [IPR018974]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor 20, ePHD domain [IPR041972]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFIIE beta subunit, DNA-binding domain [IPR003166]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF-2, domain II [IPR044145]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripartite DENN domain [IPR037516]", "Tripeptidyl-peptidase II domain [IPR034051]", "Trm3/ TARBP1, C-terminal [IPR044748]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase Lyn, SH2 domain [IPR035852]", "Tyrosine-protein kinase Lyn, SH3 domain [IPR035748]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UDP-N-acetylglucosamine 2-epimerase domain [IPR003331]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glycosyltransferase family, conserved site [IPR035595]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UME domain [IPR012993]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "UVR domain [IPR001943]", "Ubiquinol-cytochrome c reductase 8kDa, N-terminal [IPR015248]", "Ubiquinol-cytochrome c reductase, iron-sulphur subunit [IPR006317]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal [IPR032197]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 13D, UBA domain [IPR041969]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Vacuolar protein sorting-associated protein 54, N-terminal [IPR019515]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps72/YL1, C-terminal [IPR013272]", "Vta1, C-terminal [IPR041212]", "Vta1/callose synthase, N-terminal [IPR039431]", "W2 domain [IPR003307]", "WASH complex subunit 4, N-terminal [IPR028191]", "WASH complex subunit 7, C-terminal [IPR028283]", "WASH complex subunit 7, central domain [IPR028282]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "XIAP/BIRC8, UBA domain [IPR042579]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, D1 domain [IPR040992]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "Yip1 domain [IPR006977]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZCRB1, RNA recognition motif [IPR034219]", "ZMYND8/11, PWWP domain [IPR035505]", "ZN598/Hel2, RING finger [IPR041888]", "ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, BED-type [IPR003656]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-like [IPR014857]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc finger, nuclear hormone receptor-type [IPR001628]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc ribbon, NADH pyrophosphatase [IPR015376]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "bMERB domain [IPR022735]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNA/rRNA methyltransferase, SpoU type [IPR001537]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANK3", "ANKLE2", "ANO6", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "APMAP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL5B", "ARL8B", "ARMCX3", "ARMT1", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATP7B", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "BAG3", "BAG5", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCKDHA", "BCKDK", "BCR", "BCS1L", "BIRC6", "BLVRA", "BLVRB", "BMS1", "BOP1", "BPHL", "BPTF", "BRD1", "BRD2", "BRD4", "BRIX1", "BROX", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C1orf35", "C2CD2", "C3orf58", "CABIN1", "CACYBP", "CAD", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARM1", "CARS", "CARS2", "CASK", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC93", "CCNB1", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNPY2", "COA3", "COG4", "COIL", "COLEC12", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "DAG1", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCTN1", "DCUN1D1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "EARS2", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMC1", "EMC7", "EMC8", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM208A", "FAM3C", "FAM49B", "FAM8A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FOXK1", "FOXO3", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GEMIN5", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGB1", "GOPC", "GORASP2", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR89B", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2E2", "GTF3C1", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS6", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "ISOC1", "ISOC2", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "IVD", "IWS1", "JAM3", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1147", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8A", "LRRC8C", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBLAC2", "MCAT", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "METAP1", "METTL13", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MGME1", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF4GD", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL16", "MRPL2", "MRPL24", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL58", "MRPL9", "MRPS10", "MRPS23", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCLN", "NCSTN", "ND5", "NDC80", "NDUFA10", "NDUFA2", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NTHL1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDXK", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POMGNT2", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP3CA", "PPP4C", "PPP5C", "PPWD1", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRELID1", "PREP", "PREPL", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD21", "RAD23B", "RAD50", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RNASEH2A", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRP12", "RRP7A", "RSF1", "RTCA", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHPK", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A2", "SLC27A4", "SLC2A1", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPC25", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STOM", "STOML2", "STRBP", "STRIP1", "STRN", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMM10", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TKT", "TLK2", "TLN1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TP53", "TP53BP1", "TPBG", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT2A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSR1", "TST", "TSTA3", "TTC4", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UGDH", "UGGT1", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP20", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VCP", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13D", "VPS18", "VPS29", "VPS4A", "VPS4B", "VPS50", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WASHC4", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WIZ", "WNK1", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YBX1", "YBX3", "YIPF4", "YKT6", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFC3H1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZNF687", "ZPR1", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABHD10", "ACOX3", "ACSL1", "ACTN4", "ADD1", "ADNP", "AKAP1", "ALCAM", "ALDH1A2", "ALG1", "ANKLE2", "ATAD3A", "ATP13A1", "ATP2A2", "ATP2B1", "ATP7B", "ATRX", "AURKB", "BAIAP2", "BAZ1A", "BCKDHA", "BRD2", "CALU", "CASK", "CBX3", "CBX5", "CCAR1", "CCAR2", "CDC5L", "CDK1", "CDK11B", "CDK13", "CDK2", "CDKN2AIP", "CELF1", "CENPB", "CERS1", "CERS2", "CHAMP1", "CIRBP", "CLPX", "CNPY2", "CPSF6", "CPSF7", "CSK", "CSTF2", "CYB5D2", "DDX10", "DDX17", "DDX20", "DDX28", "DDX39A", "DDX42", "DDX46", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX55", "DHX29", "DHX36", "DHX37", "DHX40", "DIMT1", "DLG3", "DNAJA3", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DPF2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G3", "EPHA7", "EPHX1", "ERLIN1", "ETFB", "EWSR1", "EXOC2", "EXOSC10", "EXOSC2", "EXOSC5", "FKBP14", "FKBP7", "FLOT1", "FOXK1", "FUBP1", "FUBP3", "FUS", "FXR2", "GAK", "GATAD2A", "GATAD2B", "GRSF1", "GSK3A", "GSK3B", "H1F0", "H2AFX", "H2AFY", "H3-3A*", "HADH", "HIST1H1C", "HIST1H1E", "HLA-A", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPLL", "HNRNPR", "HNRNPUL1", "HSD17B4", "HSDL2", "IARS2", "IGF2BP2", "IMP3", "INA", "IQGAP2", "JAM3", "KDM1B", "KHDRBS3", "KHSRP", "KIF18A", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KTN1", "LAMB1", "LARP4B", "LASP1", "LGALS3BP", "LIMA1", "LMNB1", "LMNB2", "LPP", "LRP1", "LRRC8C", "LTA4H", "LYN", "MBLAC2", "MFSD10", "MID1", "MIF4GD", "MIPEP", "MPP2", "MPP7", "MSH6", "MTA1", "MTA2", "MTHFD1L", "MTHFD2", "MYEF2", "MYH10", "MYH14", "MYO1C", "MYO1D", "MYO5A", "NCBP1", "NCL", "NEFM", "NELFE", "NENF", "NGEF", "NKRF", "NOA1", "NOL8", "NOLC1", "NOM1", "NONO", "NOP2", "NPEPPS", "NRBP1", "NSUN2", "NUCB2", "OGDH", "P3H1", "P4HA2", "P4HB", "PABPC1", "PAIP1", "PARN", "PARP1", "PDCD11", "PDE12", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDLIM5", "PGRMC2", "PIAS2", "PIK3R2", "PKN1", "PLK1", "PMPCA", "POLR1B", "POLR2A", "POLR3A", "PPIL4", "PPOX", "PRDX4", "PRKCA", "PRKRA", "PROCR", "PRPF40A", "PSPC1", "PTBP2", "PTCD1", "PTGR2", "PTK7", "PTPRF", "PWP2", "QSOX2", "RABGAP1", "RACGAP1", "RALY", "RANBP9", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM26", "RBM27", "RBM3", "RBM4", "RBM45", "RBM6", "RBMX", "RBMXL1", "RBPMS", "RCN2", "REXO2", "RHOT1", "ROCK1", "RPL18", "RPRD1B", "RPS10", "RPS6KA1", "RPS6KA3", "RREB1", "S100A11", "SARNP", "SARS2", "SCAF4", "SDR39U1", "SEC63", "SF3A2", "SFPQ", "SKIV2L", "SLC12A7", "SLC16A1", "SLC18B1", "SLTM", "SMARCA1", "SMARCC2", "SMC1A", "SMC3", "SMC4", "SMC5", "SNRNP200", "SNRPA", "SON", "SPTAN1", "SRRM2", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "STAG1", "STAM", "STAU1", "STOM", "STOML2", "STRBP", "STX12", "STX17", "STX7", "SUGP1", "SUN1", "SUN2", "TAB1", "TAF15", "TAF6L", "TBCB", "TCOF1", "TFIP11", "TIA1", "TIMM44", "TMED10", "TMX1", "TMX3", "TRA2A", "TRA2B", "TRIM21", "TRIM24", "TRIM26", "TRIM28", "TRIM4", "TSR1", "TXNDC12", "TXNDC5", "TXNL1", "UBE4A", "UBR5", "UPF2", "UQCRC2", "USP19", "USP28", "USP36", "USP47", "USP48", "USP7", "VAT1", "VIM", "WDR43", "XRCC6", "YTHDC1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2", "ZC3H18", "ZCCHC3", "ZFR", "ZMYM2", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF622", "ZNF638"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..643d04e278308446012fee8ac8e16702298a0cfe --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "14-3-3 protein [IPR000308]", "1": "Small GTPase superfamily, ARF/SAR type [IPR006689]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..eb6562f4ff1be551ac7248b430f551d27b0ccc7c --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7448449ec95589139ad87909c774e9218cba421789265db656cf44a63b3257e0 +size 130031 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..621c43b1bffb461823ff141aa2ea4a8c80576c78 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f1c65a69cdfb029b619a674fa5b9ad065d77caf188df79b9c449791a0f7e7353 +size 153675 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1e70edc36d575433891ecd4eb1376e40ff058c6c --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7d53b6e16b4753f1e3d8bcfc4fbf9faefa52440767f7287c67990e180fbe3f7a +size 346586 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f905704d8bd2a7841f3e320923f537538a4183e3 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Annexin [IPR001464] 3 6 2.449812039910771 0.0142930804496084 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 0.075113296023457 2.1797401302891516e-05 0.0003286021100258 +Proteasome, subunit alpha/beta [IPR001353] 3 14 2.376951176550387 0.0174563985092772 5.075242718446602 13.970873786407768 1.2284854682369022 0.3020132543529001 2.3027355385508845 0.1681602725795027 1.1101966392985694 0.3179790146746512 1.0 0.0742352733278267 0.000453663444764 0.0004862334359502 0.0062633876942655 +Major facilitator superfamily [IPR011701] 3 5 2.373247746380356 0.0176324325370278 1.900485436893204 4.145631067961165 1.0239318262629833 0.2378354197978781 1.3191273068698348 1.552684909115802 1.329586452483978 0.2573287434106264 0.0393012238682757 0.1093006244161378 0.0015498580582828 0.0024379570615939 0.0269295467729808 +Proteasome B-type subunit [IPR023333] 3 7 2.067263917673097 0.0387092922542049 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 0.0424464003246627 7.149857972393559e-05 3.848915456526504e-05 0.0005688349419973 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..06881314064c541030bcc854aa7b59c337fb9eda --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 2394, + "title": "Average number of proteins per term", + "value": 1.2878028404344193 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..744ba75be75369d5fb656de7af6e47e92f0d7e95 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2a9c3794e014e5e3b3409783d672bbc52f64c66d --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,99 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Annexin [IPR001464] 0.9192687687169844 2.449812039910771 0.0142930804496084 0.9999999999999988 0.1173835392759239 6 P20073,P09525,P50995 3 +Proteasome, subunit alpha/beta [IPR001353] 0.7015779567969078 2.376951176550387 0.0174563985092772 1.0 0.1211264146503784 14 Q99436,P28070,P49721 3 +Major facilitator superfamily [IPR011701] 0.941703994258076 2.373247746380356 0.0176324325370278 1.0 0.1211264146503784 5 Q6NT16,P53985,Q14728 3 +Proteasome B-type subunit [IPR023333] 0.7861032878068632 2.067263917673097 0.0387092922542049 1.0 0.15760528638697 7 Q99436,P28070,P49721 3 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9911908646003258 1.681460322025488 0.0926735371922689 1.0 0.2504068262283203 2 Q99595 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.9546492659053804 1.536723977575545 0.1243609168351516 1.0 0.2983166682398326 2 O15254 1 +Acyl-CoA oxidase [IPR012258] 0.9546492659053804 1.536723977575545 0.1243609168351516 1.0 0.2983166682398326 2 O15254 1 +Linker histone H1/H5 [IPR005819] 0.731079540094921 1.5316161268645507 0.1256171905317242 1.0 0.3004271270059419 5 P16403,P07305,P10412 3 +Medium-chain dehydrogenase/reductase [IPR045010] 0.95138662316476 1.5237886279102455 0.1275615212541692 1.0 0.3032405245651898 2 Q8N8N7 1 +Aminopeptidase N-type [IPR034016] 0.7817896269272135 1.443737775793667 0.1488127510734087 1.0 0.3287072395425427 4 P55786 1 +Membrane bound O-acyl transferase, MBOAT [IPR004299] 0.925285481239801 1.4203220427122587 0.155513946754235 1.0 0.3386286183562064 2 P35610 1 +Prolyl 4-hydroxylase [IPR045054] 0.9207177814029348 1.40222801577424 0.1608471681840086 1.0 0.345973154207113 2 O15460 1 +Mpv17/PMP22 [IPR007248] 0.928851174934734 1.3603652652812646 0.1737143645566745 1.0 0.3622580041364798 3 Q9NR77,Q567V2 2 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.9096247960848264 1.358317102155378 0.174363085862115 1.0 0.3626630995255459 2 Q14739 1 +Cytochrome P450 [IPR001128] 0.9008156606851486 1.3234891240659146 0.185672770751017 1.0 0.3783603362803718 2 Q16850 1 +Nucleobindin [IPR040250] 0.9004893964110863 1.3222000742725948 0.1861015363645033 1.0 0.3785276788926261 2 P80303 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.6442051057685698 1.2986772766902208 0.1940547054986492 1.0 0.3894704302678605 6 P09960,P55786 2 +Protein disulphide isomerase [IPR005792] 0.8962140992167109 1.2432742647974178 0.2137667842450881 1.0 0.4127078076473717 3 P07237,P13667 2 +HAD hydrolase, subfamily IA [IPR006439] 0.8518760195758472 1.1312279926809048 0.2579591428214582 1.0 0.4636292702061345 2 P34913 1 +Haloacid dehalogenase-like hydrolase [IPR041492] 0.8518760195758472 1.1312279926809048 0.2579591428214582 1.0 0.4636292702061345 2 P34913 1 +Haem oxygenase [IPR002051] 0.8456769983686712 1.107093228698164 0.2682536228221956 1.0 0.4722052742914239 2 P30519 1 +Haem oxygenase-like [IPR016053] 0.8456769983686712 1.107093228698164 0.2682536228221956 1.0 0.4722052742914239 2 P30519 1 +TAF15/EWS/TLS family [IPR034870] 0.8419581544481354 1.050239922206 0.2936078189853175 1.0 0.4953468066602185 3 Q92804 1 +CPSF6/7 family [IPR034772] 0.8179445350734085 1.0000149779053271 0.3173032594879896 1.0 0.5178077731521794 2 Q8N684 1 +RNA-binding protein 26/27 [IPR045137] 0.8176182707993386 0.9987652673052498 0.3179084150923486 1.0 0.5182000350650433 2 Q9P2N5 1 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.8188575383220927 0.9691935077491438 0.3324486497072469 1.0 0.5320067295448859 3 Q5BKZ1 1 +Cohesin subunit Scc3/SA [IPR039662] 0.7924959216965641 0.903398558482452 0.366314404787015 1.0 0.5603644989966878 2 Q8WVM7 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.7911908646003242 0.898495615589597 0.3689213816166181 1.0 0.5615221342829432 2 P07910 1 +KH domain-containing BBP-like [IPR045071] 0.640757251667637 0.8947180047863827 0.3709378514833596 1.0 0.5632160721526412 4 O75525,Q96PU8 2 +P-type ATPase [IPR001757] 0.5731670888239544 0.876199541267322 0.3809215658738092 1.0 0.5720992651831237 5 P16615,P35670,Q9HD20 3 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.7830342577487739 0.8679811063848968 0.3854046758393923 1.0 0.5757026934346046 2 Q9NVI7 1 +THRAP3/BCLAF1 family [IPR029199] 0.7820554649265907 0.8643348267562064 0.387403983728908 1.0 0.5771282744536439 2 Q9Y2W1 1 +Ribosomal protein S6 kinase II [IPR016239] 0.7595432300163059 0.7814839472797502 0.4345179145094344 1.0 0.6151601935751544 2 Q15418 1 +Transcriptional repressor p66 [IPR040386] 0.7556280587275628 0.7672909860723821 0.4429085265371839 1.0 0.6222552890434381 2 Q8WXI9 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.7583359607277379 0.7625575425959271 0.4457273135082031 1.0 0.6240419606214451 3 Q9HB40 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.7520391517128778 0.754342172132461 0.4506437855383907 1.0 0.626504775016787 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.7520391517128778 0.754342172132461 0.4506437855383907 1.0 0.626504775016787 2 Q93050 1 +Cell cycle and apoptosis regulator protein [IPR025224] 0.7422512234910275 0.7193410070610186 0.4719308354157463 1.0 0.6426634925968695 2 Q8N163 1 +Tropomyosin [IPR000533] 0.7216965742251132 0.6474818306844956 0.5173201500050066 1.0 0.6716913853558532 2 P06753 1 +Stomatin/HflK/HflC family [IPR001972] 0.7171288743882485 0.6318446631638728 0.5274883856310886 1.0 0.6785637803335981 2 P27105 1 +Mitochondrial Rho GTPase [IPR021181] 0.7135399673735705 0.6196492251987807 0.5354887509241948 1.0 0.6850015847483797 2 Q8IXI2 1 +Chaperone DnaJ [IPR012724] 0.7061233947878158 0.5946056329153929 0.5521071139042415 1.0 0.6949234651349917 3 Q96EY1 1 +HnRNP-L/PTB [IPR006536] 0.5587310761653983 0.5940193974831861 0.5524991392226846 1.0 0.6950514657378386 4 Q9UKA9 1 +Syntaxin [IPR045242] 0.4511185595880467 0.5698147838140284 0.5688033273470801 1.0 0.7076150446151044 7 Q86Y82 1 +La domain containing protein [IPR045180] 0.4924437802597384 0.560352257968386 0.5752391892067876 1.0 0.712059265233221 5 Q92615 1 +Tropomodulin [IPR004934] 0.6900489396411069 0.5419574230184842 0.587847837087832 1.0 0.7198504971807006 2 Q9NYL9 1 +Nuclear pore complex protein [IPR026054] 0.6733028720626676 0.496190908732587 0.6197597245915281 1.0 0.7422235020871026 3 P49790,A8CG34 2 +HnRNP R/Q splicing factor [IPR006535] 0.6750407830342533 0.4944529280067079 0.6209863423451112 1.0 0.7425698020299557 2 O43390 1 +Epoxide hydrolase-like [IPR000639] 0.6634525635442625 0.4679849975810822 0.6397953182911087 1.0 0.7560069062136793 3 P07099 1 +Flotillin family [IPR027705] 0.653833605220222 0.4305339378863164 0.666807284851064 1.0 0.7715498501369972 2 O75955 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.643920947970365 0.4141114528343936 0.6787924856303291 1.0 0.7779812560633022 3 Q99436 1 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.6267536704730697 0.3550395987933594 0.7225599256433044 1.0 0.7982503285602541 2 O60884 1 +Peptidase M3A/M3B [IPR045090] 0.6178065452158072 0.3467846464101974 0.7287531125874804 1.0 0.8006972989314775 3 Q99797 1 +Pre-mRNA-splicing factor Syf1-like [IPR045075] 0.6105584537897859 0.329133925205972 0.7420544628483283 1.0 0.8056591310924708 3 Q9BZJ0 1 +Ribosome biogenesis protein Bms1/Tsr1 [IPR039761] 0.6114192495921602 0.3156506562813417 0.7522676837017355 1.0 0.8103107174088245 2 Q2NL82 1 +Peptidyl-tRNA hydrolase, PTH2 [IPR002833] 0.6052202283849818 0.3004619332024539 0.7638248286579723 1.0 0.81926372751218 2 Q9Y3E5 1 +Nucleolar, Nop52 [IPR010301] 0.5905383360521904 0.2662414069985419 0.7900532952774799 1.0 0.8365270185290964 2 Q14684 1 +Ribosomal protein S17/S11 [IPR000266] 0.5755301794453384 0.2338869437425739 0.815072749511409 1.0 0.8569539579843273 2 Q9Y2R5 1 +14-3-3 protein [IPR000308] 0.3511924207775224 0.1695940073191553 0.8653294357436558 1.0 0.9034446878195866 6 P62258,Q04917,P63104,P61981,P31946 5 +HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380] 0.4066584875371201 0.1685806912876973 0.866126469292104 1.0 0.9038826362185252 4 Q86UY8 1 +Cell-cycle alteration and expression-elevated protein in tumour [IPR032337] 0.5216118358774793 0.1544864674790023 0.8772261805174744 1.0 0.9134751962413368 3 Q9NQG5 1 +Ribosomal protein L37/S30 [IPR010793] 0.5269168026100992 0.1479987170860752 0.8823437807100545 1.0 0.91800565450668 2 Q9NP92 1 +Purine 5'-nucleotidase [IPR016695] 0.5122795891211156 0.1409519626268796 0.887907891634877 1.0 0.922113034615528 3 Q86UY8 1 +Tricarboxylate/iron carrier [IPR004686] 0.5122611996047377 0.140926204556216 0.8879282404917404 1.0 0.922113034615528 3 Q96NB2 1 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.5050570962479479 0.1187779667532075 0.9054512650748424 1.0 0.9363500339478068 2 P11940 1 +Prenyltransferase subunit beta [IPR045089] 0.4933115823817103 0.105379443164308 0.9160747272111394 1.0 0.945294352130805 2 P53609 1 +SLC12A transporter family [IPR004842] 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 0.947708742048285 2 Q9Y666 1 +26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134] 0.4799347471451717 0.0919804152750374 0.9267135999656172 1.0 0.9547432181182346 2 Q9BT78 1 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666] 0.3561867450212231 0.0892555727758533 0.9288788008796552 1.0 0.9560343290223106 4 Q96BP3,Q9H2H8,Q9Y3C6 3 +Structural maintenance of chromosomes protein [IPR024704] 0.3525954946131245 0.0849151922891257 0.9323288137116366 1.0 0.95838456373099 4 Q9UQE7,Q9NTJ3,Q14683 3 +Kinesin-like protein [IPR027640] 0.2958990998787916 0.084871862061028 0.9323632618753032 1.0 0.95838456373099 9 O00139,Q99661,Q8NI77,P33176 4 +Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276] 0.461011419249585 0.0761898985807361 0.9392680190951754 1.0 0.9638266771169524 2 O75880 1 +Copper chaperone SCO1/SenC [IPR003782] 0.461011419249585 0.0761898985807361 0.9392680190951754 1.0 0.9638266771169524 2 O75880 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.4567699836867644 0.0731258903072785 0.9417059393221748 1.0 0.9655006504228206 2 Q96KA5 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.4567699836867644 0.0731258903072785 0.9417059393221748 1.0 0.9655006504228206 2 Q96KA5 1 +Ribosomal protein L3 [IPR000597] 0.455138662316456 0.0719913751789677 0.942608771652369 1.0 0.9657818543403842 2 P39023 1 +Isocitrate dehydrogenase NAD-dependent [IPR004434] 0.4548123980424005 0.0717673606000045 0.9427870482846608 1.0 0.9657818543403842 2 O43837 1 +Serine-tRNA ligase, type1 [IPR002317] 0.4525285481239748 0.070225949081842 0.944013820927284 1.0 0.9666249304105724 2 Q9NP81 1 +Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672] 0.4363577023498701 0.0635034296234879 0.9493656283136912 1.0 0.9708591688094732 3 Q6UB35,P13995 2 +Vinculin/alpha-catenin [IPR006077] 0.4401305057096112 0.0626437361245019 0.9500502013966752 1.0 0.971144398865773 2 P35221 1 +Luc7-related [IPR004882] 0.4375203915171245 0.0612090524584698 0.9511927204332842 1.0 0.9714826675415028 2 Q9Y383 1 +Small GTPase superfamily, ARF/SAR type [IPR006689] 0.2780503761858027 0.0592051038128298 0.95278874452101 1.0 0.97269776306324 10 P84085,Q9Y6B6,Q8N8L6,P36404,Q96KC2,P18085,Q9NR31,P36405,Q9NVJ2 9 +RNA (C5-cytosine) methyltransferase [IPR023267] 0.42656657963447 0.0573182313071657 0.9542916977443604 1.0 0.9734019277375368 3 P46087,Q08J23 2 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936] 0.4203655352480498 0.0537823017573587 0.9571086102608056 1.0 0.9746776286472902 3 Q9H2H8,Q9Y3C6 2 +DNA-directed RNA polymerase, subunit beta-prime [IPR045867] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 0.9749162165159336 3 P24928,O14802 2 +Ribosomal protein L15 [IPR030878] 0.4169657422512192 0.0516835886341208 0.9587808141341034 1.0 0.9754871521619396 2 Q9P015 1 +Ribosomal protein S4/S9 [IPR022801] 0.4153344208809107 0.0510520852995186 0.9592840165596754 1.0 0.9755845096193132 2 Q9NV31 1 +LanC-like protein, eukaryotic [IPR020464] 0.3895595432300154 0.0431201245630066 0.9656057771366164 1.0 0.9782734788256706 2 O43813 1 +Lanthionine synthetase C-like [IPR007822] 0.3895595432300154 0.0431201245630066 0.9656057771366164 1.0 0.9782734788256706 2 O43813 1 +Erlin1/2 [IPR033294] 0.3836867862968968 0.0417832551510279 0.966671483808691 1.0 0.9785446965087466 2 O75477 1 +Ribosomal protein L10P [IPR001790] 0.3941038385675325 0.0417587983838144 0.966690980469167 1.0 0.9785446965087466 3 Q7Z7H8 1 +Protein phosphatase 2C family [IPR015655] 0.3035537893320391 0.0412391223045234 0.9671052650981852 1.0 0.9785502978212404 4 Q15750 1 +Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737] 0.3448613376835243 0.0361117728409099 0.97119323508202 1.0 0.9814422139241687 2 Q9UNQ2 1 +Ribosomal RNA adenine dimethylase [IPR011530] 0.3448613376835243 0.0361117728409099 0.97119323508202 1.0 0.9814422139241687 2 Q9UNQ2 1 +DNA-directed RNA polymerase, subunit 2 [IPR015712] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 0.981446836796422 2 Q9H9Y6 1 +AP-1/2/4 complex subunit beta [IPR016342] 0.291027732463296 0.0335480082714198 0.9732375822933046 1.0 0.9823246837470392 2 Q10567 1 +Calcium uptake protein 1/2/3 [IPR039800] 0.2867862969004892 0.033472904514038 0.973297472785287 1.0 0.9823246837470392 2 Q9BPX6 1 +Histone H2A [IPR002119] 0.327023498694522 0.0269440089217465 0.9785043922021864 1.0 0.9867479001398628 3 P16104,O75367 2 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..73332d210854dcbfecbdc91b57e4fc9f15b8ad63 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-oxoisovalerate dehydrogenase subunit alpha [IPR034616]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome non-ATPase regulatory subunit 9 [IPR035269]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S10, mitochondrial [IPR040055]", "28S ribosomal protein S17, mitochondrial [IPR039193]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3'5'-cyclic nucleotide phosphodiesterase [IPR023088]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-keto-steroid reductase [IPR042829]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease 1 [IPR016494]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-formyltetrahydrofolate cyclo-ligase [IPR002698]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "50S ribosomal protein uL4 [IPR013005]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 10 [IPR042951]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "ALG11 mannosyltransferase [IPR038013]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1 complex subunit sigma [IPR044733]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit A [IPR000568]", "ATP synthase, F0 complex, subunit A, bacterial/mitochondria [IPR045083]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-binding cassette sub-family C member 4 [IPR030240]", "ATP-binding cassette subfamily B member 10-like [IPR030260]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Abr/Bcr [IPR037769]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 2/3 complex subunit 5 [IPR006789]", "Actin-related protein 3 [IPR015623]", "Activating signal cointegrator 1 complex subunit 1 [IPR009210]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-CoA-binding domain-containing protein 5 [IPR016347]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenomatous polyposis coli (APC) family [IPR026818]", "Adenomatous polyposis coli [IPR026836]", "Adenosine deaminase [IPR028893]", "Adenosine kinase [IPR001805]", "Adenosine/adenine deaminase [IPR006330]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Aldose 1-/Glucose-6-phosphate 1-epimerase [IPR008183]", "Aldose 1-epimerase [IPR015443]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 2 [IPR044554]", "Anaphase-promoting complex subunit 4 [IPR024789]", "Anaphase-promoting complex subunit 4, metazoa [IPR017169]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 2 [IPR005293]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat protein deleted in velo-cardio-facial syndrome [IPR028444]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase B [IPR028772]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 9 [IPR007241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCAS3-like [IPR045142]", "BCP1 family [IPR025602]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "BRO1 domain-containing protein BROX [IPR038898]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Band-7 stomatin-like [IPR043202]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-2-syntrophin [IPR028550]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [IPR013109]", "Bifunctional polynucleotide phosphatase/kinase PNKP [IPR006550]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biorientation of chromosomes in cell division protein 1-like 1 [IPR043244]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 2-like [IPR039934]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD166 antigen [IPR039810]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD34/Podocalyxin [IPR013836]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDC50/LEM3 family [IPR005045]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CGG triplet repeat-binding protein 1 [IPR033375]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation efflux protein [IPR002524]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle control protein 50A [IPR030351]", "Cell cycle regulator Mat89Bb [IPR019355]", "Cell division cycle protein 123 [IPR009772]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centromere protein Cenp-F [IPR043513]", "Centromere protein I [IPR012485]", "Centromere protein P [IPR027801]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Charged multivesicular body protein 1a [IPR029888]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin modification-related protein Eaf7/MRGBP [IPR012423]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromodomain-helicase-DNA-binding protein 8 [IPR034724]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 127 [IPR034607]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 137 [IPR026680]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 43 [IPR037666]", "Coiled-coil domain-containing protein 51 [IPR037660]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 90-like [IPR024461]", "Coiled-coil domain-containing protein 93 [IPR039116]", "Coilin [IPR024822]", "Complex I intermediate-associated protein 30, mitochondrial [IPR039131]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 6 [IPR010490]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Core-binding factor, beta subunit [IPR003417]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin 7 [IPR027331]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cys/Met metabolism, pyridoxal phosphate-dependent enzyme [IPR000277]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "D-glucuronyl C5-epimerase [IPR039721]", "DAD/Ost2 [IPR003038]", "DDB1- and CUL4-associated factor 16 [IPR028216]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase alpha, subunit B [IPR016722]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA polymerase epsilon, subunit B [IPR016266]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad4 [IPR004583]", "DNA repair protein Rad4, subgroup [IPR018026]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication ATP-dependent helicase/nuclease Dna2 [IPR026851]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "DUF5568 family [IPR040419]", "Daxx protein [IPR005012]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Dehydrogenase/reductase SDR member 4-like [IPR029511]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Disks large 1-like [IPR016313]", "Divalent ion tolerance protein, CutA [IPR004323]", "Divergent protein kinase domain 2A/B [IPR020519]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dpy-19/Dpy-19-like [IPR018732]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1 [IPR027741]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dysbindin [IPR007531]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 SUMO-protein ligase PIAS2 [IPR027228]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase RNF213 [IPR031248]", "E3 ubiquitin-protein ligase ZNF598/Hel2 [IPR044288]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ER membrane protein complex subunit 8/9 [IPR005366]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "ESCRT-II complex, Vps25 subunit [IPR008570]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Endonuclease III-like protein 1 [IPR030841]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelial protein C receptor [IPR015669]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ephrin [IPR031328]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Erbin [IPR032927]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Essential MCU regulator, mitochondrial [IPR018782]", "Esterase-like [IPR000801]", "Etoposide-induced 2.4 [IPR009890]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Exo84 [IPR033961]", "Exocyst complex component Sec8/EXOC4 [IPR039682]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM105 [IPR023235]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM177 family [IPR028260]", "FAM3 family [IPR039220]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Far11/STRP [IPR040185]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 2 [IPR030305]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fyv7/TAP26 [IPR013730]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein alpha subunit, group Q [IPR000654]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI transamidase subunit PIG-U [IPR009600]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP cyclohydrolase 1 type 2/Nif3 [IPR002678]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "Galactokinase [IPR000705]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gem-associated protein 4 [IPR033265]", "Geranylgeranyl transferase type-1 subunit beta [IPR041960]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glucocorticoid receptor [IPR001409]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose transporter GLUT [IPR045263]", "Glucose transporter, type 1 (GLUT1) [IPR002439]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycosyltransferase 61 [IPR007657]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgi-associated PDZ and coiled-coil motif-containing protein [IPR038879]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "Guided entry of tail-anchored proteins factor CAMLG [IPR016719]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 1 [IPR026243]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS augmin-like complex subunit 6 [IPR026797]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HIRA-interacting protein 3 [IPR037647]", "HMG-CoA lyase [IPR043594]", "HS1-associating protein X-1 [IPR017248]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 12A [IPR026685]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H3/CENP-A [IPR000164]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex subunit SAP30/SAP30-like [IPR024145]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone transcription regulator 3/CABIN1 [IPR033053]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase SETD1A [IPR037841]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Set1-like [IPR044570]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Huntingtin-interacting protein 1 [IPR030554]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxyacylglutathione hydrolase [IPR017782]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Innexin [IPR000990]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integral membrane protein SYS1 [IPR016973]", "Integral membrane protein SYS1-related [IPR019185]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 12 [IPR039053]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intron Large complex component GCFC2-like [IPR012890]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isochorismatase domain-containing protein 2 [IPR040318]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "Junctional adhesion molecule C [IPR042974]", "K/Cl co-transporter 4 [IPR030354]", "K/Cl co-transporter [IPR000076]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore Mis14/Nsl1 [IPR013950]", "Kinetochore protein Ndc80 [IPR005550]", "Kinetochore protein Spc25 [IPR045143]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-rich repeat-containing 41 [IPR026137]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Lipoma-preferred partner [IPR028771]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "LysM and putative peptidoglycan-binding domain-containing protein 1-4 [IPR045030]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "M-phase phosphoprotein 6 [IPR019324]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICAL3 [IPR029941]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Magnesium transporter protein 1 [IPR006844]", "Major centromere autoantigen B [IPR033062]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Matrix-remodeling-associated protein 7 [IPR026622]", "Mediator complex, subunit Med14 [IPR013947]", "Mediator complex, subunit Med24, [IPR021429]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionine-tRNA synthetase, type 2 [IPR023457]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylmalonic aciduria and homocystinuria type D protein [IPR019362]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "Mff/Tango-11 [IPR008518]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microfibrillar-associated protein 1 [IPR033194]", "Microtubule associated protein 1 [IPR026074]", "Microtubule associated protein 1A [IPR015656]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein 7 family [IPR008604]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial calcium uniporter regulator 1 [IPR012439]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial dynamics protein MID49/MID51 [IPR045909]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit TIM22 [IPR039175]", "Mitochondrial import inner membrane translocase subunit Tim10 [IPR027100]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial intermembrane space import and assembly protein 40 [IPR039289]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial outer membrane transport complex protein, metaxin [IPR017410]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitoguardin [IPR019392]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mortality factor 4-like protein 2 [IPR038012]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multifunctional methyltransferase subunit Trm112 [IPR039127]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [IPR033202]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-plastoquinone oxidoreductase, chain 5 subgroup [IPR018393]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-quinone oxidoreductase, chain 5-like [IPR003945]", "NADH-quinone oxidoreductase, chain I [IPR010226]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NF-kappa-B/Dorsal [IPR000451]", "NIF3-like protein 1, animal [IPR017222]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "NURS complex subunit red1 [IPR039278]", "Nck-associated protein 1 [IPR019137]", "Nectin-2 [IPR033318]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neutral amino acid SLC6 transporter [IPR002438]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nicotinate-nucleotide pyrophosphorylase [IPR004393]", "Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD [IPR027277]", "Nitric oxide synthase-interacting protein [IPR016818]", "Non-structural maintenance of chromosomes element 1 [IPR011513]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Not2/Not3/Not5 [IPR040168]", "Nuclear MIS12/MIND complex subunit PMF1/Nnf1 [IPR007128]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor NF-kappa-B, p100 subunit [IPR030497]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear hormone receptor [IPR001723]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear pore protein POM121 [IPR026090]", "Nuclear protein DGCR14/ESS-2 [IPR019148]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "Nurim-like [IPR033580]", "OCIA domain-containing protein 1/2 [IPR040187]", "Occludin [IPR002958]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Optineurin [IPR032939]", "Origin recognition complex, subunit 3 [IPR020795]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IB [IPR027256]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PP2B [IPR043360]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pannexin [IPR039099]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 [IPR012462]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 1 [IPR002467]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Periphilin-1 [IPR028851]", "Peroxin-3 [IPR006966]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisome membrane protein, Pex16 [IPR013919]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatase Gpp1/Gpp2-like [IPR045228]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylase kinase alpha/beta subunit [IPR008734]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Podocalyxin [IPR017403]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyadenylate-binding protein-interacting protein 2-like [IPR040396]", "Polycomb protein EED [IPR037352]", "Polynucleotide kinase 3 phosphatase [IPR013954]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prefoldin, subunit 4 [IPR016661]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable C-mannosyltransferase DPY19L3 [IPR030039]", "Probable methyltransferase TARBP1 [IPR025806]", "Probable methyltransferase Trm3/TARBP1 [IPR045330]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Prostate apoptosis response 4 [IPR026117]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome inhibitor PI31-like [IPR045128]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM3C [IPR039219]", "Protein FAM8A1 [IPR039871]", "Protein FRG1 [IPR010414]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LCHN/Anr2 [IPR018626]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein Mon2-like [IPR026829]", "Protein NDRG3 [IPR030692]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SON [IPR032922]", "Protein Sec13 [IPR037596]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein XRP2 [IPR039093]", "Protein Yip1/4-like [IPR045231]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein jagunal [IPR009787]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C, alpha/beta/gamma types [IPR014375]", "Protein kinase C, delta [IPR027436]", "Protein kinase C, delta/epsilon/eta/theta types [IPR014376]", "Protein kinase C-binding protein 1 [IPR021931]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF1387 [IPR009816]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF4615 [IPR029274]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase 4 core regulatory subunit R2 [IPR015267]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein spinster-like [IPR044770]", "Protein strawberry notch [IPR026741]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative peptidyl-tRNA hydrolase PTRHD1 [IPR042237]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate homeostasis protein [IPR011078]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "RAD3/XPD family [IPR001945]", "RFT1 [IPR007594]", "RFX-like DNA-binding protein [IPR039779]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 1 [IPR017770]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein 6 [IPR028806]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "ROK family [IPR000600]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab protein geranylgeranyltransferase component A [IPR001738]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab4 [IPR041819]", "Rab9 [IPR041824]", "Rad21/Rec8-like protein [IPR039781]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Ran-interacting Mog1 protein [IPR007681]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein [IPR039360]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Ras-related protein Rap2 [IPR041840]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Regulatory associated protein of TOR [IPR004083]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulon-4-interacting protein 1 [IPR037397]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma protein family [IPR028309]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein 7 [IPR040446]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, bacterial-type [IPR005823]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L16 [IPR000114]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27/L41, mitochondrial [IPR019189]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L55, mitochondrial [IPR018615]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein Rsm22-like [IPR015324]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S16 [IPR000307]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S18 [IPR001648]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S27/S33, mitochondrial [IPR013219]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome recycling factor [IPR002661]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "Rieske iron-sulphur protein [IPR014349]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3 and PX domain-containing protein 2B [IPR030512]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNARE associated Golgi protein [IPR032816]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SSNA1 family [IPR033362]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BAF60B [IPR030090]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1 [IPR027109]", "SWR1-complex protein 5/Craniofacial development protein 1/2 [IPR027124]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sarcolemmal membrane-associated protein [IPR030498]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Schlafen family [IPR029684]", "Sds3-like [IPR013907]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "Sec20 [IPR005606]", "SecY/SEC61-alpha family [IPR002208]", "Sedoheptulokinase [IPR042027]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 6 [IPR030644]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase TOUSLED-like 2 [IPR027086]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sla2 family [IPR030224]", "Slowmo/Ups family [IPR037365]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snapin [IPR017246]", "Snapin/Pallidin/Snn1 [IPR028119]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium/solute symporter [IPR001734]", "Sodium:dicarboxylate symporter [IPR001991]", "Sodium:neurotransmitter symporter [IPR000175]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-4 [IPR034783]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingolipid delta(4)-desaturase DES1 [IPR031196]", "Sphingolipid delta4-desaturase [IPR011388]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Stomatin [IPR028515]", "Stomatin/HflK/HflC family [IPR001972]", "Stromal interaction molecule 1 [IPR030463]", "Stromal interaction molecule [IPR037608]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar/inositol transporter [IPR003663]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syndetin [IPR040047]", "Syntaxin [IPR045242]", "Syntaxin-17 [IPR028676]", "Syntaxin-3 [IPR031186]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "Syntrophin [IPR015482]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex subunit 7/Mft1 [IPR008501]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM70 family [IPR009724]", "TMEM70/TMEM186/TMEM223 protein family [IPR045325]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TPX2 [IPR009675]", "TREX component Tex1/THOC3 [IPR040132]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Telomeric repeat-binding factor 1/2 [IPR017357]", "Telomeric repeat-binding factor 2 [IPR030657]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 21A/21B [IPR040364]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation factor, mitochondrial [IPR039150]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor II-I [IPR016659]", "Transcription factor IIA, alpha/beta subunit [IPR004855]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription initiation factor TFIIE, beta subunit [IPR016656]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transforming growth factor-beta-related [IPR015615]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation initiation factor aIF-2, bacterial-like [IPR000178]", "Translation machinery-associated protein 16 [IPR021346]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 161A/B [IPR019395]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 41A/B [IPR045014]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Trm112-like [IPR005651]", "Tropomodulin [IPR004934]", "Tropomodulin-1 [IPR030135]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tryptophan-tRNA ligase, bacterial-type [IPR024109]", "TspO/MBR-related protein [IPR004307]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Type-1 angiotensin II receptor-associated protein [IPR009436]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing [IPR020004]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronosyl/UDP-glucosyltransferase [IPR002213]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0767 family [IPR031933]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "UbiE/COQ5 methyltransferase [IPR004033]", "Ubiquinol-cytochrome-c reductase complex assembly factor 2 [IPR037698]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin thioesterase otulin [IPR023237]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-like modifier-activating enzyme Atg7 [IPR006285]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Ubiquitously expressed transcript protein UXT [IPR003994]", "Uncharacterised protein family UPF0449 [IPR028227]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Ureohydrolase [IPR006035]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein sorting-associated protein Vta1-like [IPR044538]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Vezatin [IPR026858]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "Vps52 [IPR007258]", "Vps72/YL1 family [IPR008895]", "WASH complex subunit 7 [IPR027307]", "WASH complex, subunit strumpellin [IPR019393]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat and coiled-coil-containing protein family [IPR028041]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "ZPR1 family [IPR040141]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 [IPR044598]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger protein 277 [IPR040048]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 622/Rei1/Reh1 [IPR040025]", "Zinc finger protein 638 [IPR033096]", "Zinc transporter Msc2-like [IPR045316]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "siRNA-mediated silencing protein NRDE-2 [IPR013633]", "tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 [IPR014816]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase, Trm7 [IPR028590]", "tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote [IPR025763]", "tRNA (guanine-N-7) methyltransferase, Trmb type [IPR003358]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGL", "AGPS", "AGTRAP", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "API5", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAIAP2", "BANF1", "BASP1", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUD31", "BYSL", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C3orf58", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CAD", "CALD1", "CALR", "CALU", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CAST", "CBFB", "CBR1", "CBR4", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK5RAP3", "CDKAL1", "CDS2", "CDV3", "CEBPZ", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1L", "CHD8", "CHERP", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CIAPIN1", "CIP2A", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG6", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX54", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX29", "DIABLO", "DIAPH1", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPM1", "DPP3", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EED", "EEF1A2", "EEF1E1", "EEF1G", "EFNB1", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "F11R", "FADS2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GCAT", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMFB", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HCCS", "HCFC1", "HDAC2", "HDHD2", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IRGQ", "IRS4", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMF2", "LNPEP", "LONP1", "LPP", "LRPAP1", "LRPPRC", "LRRC41", "LRRC47", "LSM12", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MIPEP", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTR", "MTX1", "MTX2", "MTX3", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "NAA10", "NAA15", "NAA35", "NAA40", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCLN", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF1", "NDUFAF3", "NDUFB10", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NELFCD", "NELFE", "NES", "NF1", "NFKB2", "NHP2", "NIF3L1", "NIP7", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRDE2", "NRM", "NSA2", "NSF", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAIP2", "PAK2", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PAWR", "PBDC1", "PBRM1", "PC", "PCBD1", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM5", "RBM6", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX1", "RIOX2", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTFDC1", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARS", "SARS2", "SART1", "SBDS", "SBNO1", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A21", "SLC25A24", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLK", "SLMAP", "SLTM", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMIM12", "SMPD4", "SMS", "SMU1", "SNAPIN", "SND1", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPATS2L", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPNS1", "SPR", "SPTBN1", "SPTBN2", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF6", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAT1", "STAT3", "STIM1", "STIP1", "STMN1", "STOM", "STOML2", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", 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b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +MFS transporter superfamily [IPR036259] 7 11 2.774612900357176 0.0055267447360525 3.6432038834951457 8.356796116504855 0.9436301622284156 0.2543148229816532 1.924895010927015 2.2984539817025564 1.2198539986610124 0.2448337840515702 0.0771453392648563 0.0221752921752284 6.3490034575816514e-06 1.7283935081196885e-05 0.0019780921583714 +Protein kinase-like domain superfamily [IPR011009] 15 60 2.632546349213431 0.0084747458869109 20.41990291262136 70.37378640776699 -0.1027148677914017 0.6421551859523025 9.026438620260558 14.97574389072516 0.8497696380066302 0.3174331396666366 0.0214569248996702 0.0303639743915621 0.0090461694187312 0.3943717158443946 0.7046094671515515 +Tetratricopeptide-like helical domain superfamily [IPR011990] 12 80 2.515484953906424 0.0118868750926881 22.856796116504853 85.5631067961165 0.5676132842696584 0.6143258973719493 7.683128498309678 5.891280215778877 0.9202004538980384 0.371378017802006 0.0325916703599929 0.0091819187009941 0.0861470699703376 0.0009618332164347 0.0200949512935085 +Annexin superfamily [IPR037104] 3 6 2.449812039910771 0.0142930804496084 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 0.075113296023457 2.1797401302891516e-05 0.0003286021100258 +Alpha/Beta hydrolase fold [IPR029058] 8 26 2.241145925881188 0.0250166241696394 7.793689320388349 25.487864077669904 0.3803730368869525 0.1931612116461074 2.8504230618688027 2.5849355029363217 1.9090082785106757 0.2379814650369476 0.1061054399835465 0.0002888849821262 3.5484935840982423e-06 3.1176850956108185e-05 0.0048394274978242 +Mitochondrial carrier domain superfamily [IPR023395] 3 18 2.220733469915304 0.0263690190754262 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 0.1675604235637086 0.0523352985295366 0.0130060888805635 0.0353817250131281 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 2 6 2.2115063660936296 0.0270007915217753 2.3689320388349513 6.349514563106796 0.6640264147492347 0.3307390797434538 1.7803691733569 2.1393617497725477 1.1694677427725269 0.279101120079799 0.0247368002912169 0.0697581245313758 0.1362380906066266 0.0051503840765812 0.0334620993119388 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 3 6 2.135003648272135 0.0327607121192905 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 1.0 0.0014481500629001 0.0057815105752346 0.0328731354880699 0.0001575214550341 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..82083cc96f1f789a01a56a20ecb757a5a6ed08c5 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 944, + "title": "Average number of proteins per term", + "value": 4.802966101694915 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..df595534de4c014f2e924802d40432f81f1f94f9 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3c44c8c39dc554c5c345068f02ee2b29398e81e7 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,114 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +MFS transporter superfamily [IPR036259] 0.8636919890365331 2.774612900357176 0.0055267447360525 0.994655661851128 0.2214283455581304 11 Q6NT16,Q14728,Q9H2V7,Q99808,Q6N075,P41440,P53985 7 +Protein kinase-like domain superfamily [IPR011009] 0.5233040861299043 2.632546349213431 0.0084747458869109 0.9996758332559053 0.2214283455581304 60 Q9HA64,Q96GD4,P07948,Q14004,O14936,P49840,Q13464,P49841,P17252,O14976,Q8NI60,P53350,P06493,P24941,P21127 15 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.4904122789701127 2.515484953906424 0.0118868750926881 0.9999874831637088 0.2214283455581304 80 Q13217,Q9NSK0,Q7L5D6,O15091,Q92791,O75718,Q5R3I4,Q32P28,O15460,P13674,Q6DKK2,O75153 12 +Annexin superfamily [IPR037104] 0.9192687687169844 2.449812039910771 0.0142930804496084 0.9999987470660758 0.2214283455581304 6 P20073,P09525,P50995 3 +Alpha/Beta hydrolase fold [IPR029058] 0.5900783028991478 2.241145925881188 0.0250166241696394 0.999999999958945 0.2231131037052294 26 P07099,P34913,Q4J6C6,Q9HB40,Q8NCC3,P42785,Q9NUJ1,Q9UMR5 8 +Mitochondrial carrier domain superfamily [IPR023395] 0.6445137598457216 2.220733469915304 0.0263690190754262 0.9999999999889262 0.2232146692429903 18 Q9BQT8,Q70HW3,O43772 3 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.8597507106721607 2.2115063660936296 0.0270007915217753 0.9999999999939996 0.2232146692429903 6 P08183,O15439 2 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.8409825631048321 2.135003648272135 0.0327607121192905 0.999999999999978 0.2421666488540909 6 Q9UMX5,Q8WUJ1,O15173 3 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.5996648902816102 1.9562466258362825 0.0504361083646873 1.0 0.2898300309300035 18 Q99436,P28070,P49721 3 +Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100] 0.7047566772426218 1.9257212129431025 0.0541391936863531 1.0 0.2949921053134167 10 O15254 1 +Acyl-CoA dehydrogenase-like, C-terminal [IPR036250] 0.7047566772426218 1.9257212129431025 0.0541391936863531 1.0 0.2949921053134167 10 O15254 1 +GroES-like superfamily [IPR011032] 0.6911150471541262 1.8608925021472256 0.0627593588232553 1.0 0.3219827974410491 10 Q99536,Q8N4Q0,Q8N8N7 3 +Aldehyde dehydrogenase, C-terminal [IPR016163] 0.688746832669473 1.7552678100381778 0.0792135098206126 1.0 0.3629978314109625 9 O94788 1 +Aldehyde dehydrogenase, N-terminal [IPR016162] 0.688746832669473 1.7552678100381778 0.0792135098206126 1.0 0.3629978314109625 9 O94788 1 +Aldehyde/histidinol dehydrogenase [IPR016161] 0.688746832669473 1.7552678100381778 0.0792135098206126 1.0 0.3629978314109625 9 O94788 1 +Homeobox-like domain superfamily [IPR009057] 0.5557971691971727 1.7305572654595025 0.0835307592392484 1.0 0.3684721342142549 19 Q96G23,Q8TAQ2,Q9NYB0,Q96JN0,Q99459,Q9H2P0,Q99543,Q13330,Q8NB78,Q96KC8 10 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5248110570982086 1.621663619961919 0.1048753924213978 1.0 0.4159763464109227 21 Q9UHG3,O95831 2 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.6738721830758511 1.5715984053406644 0.1160437165374896 1.0 0.4464468099965221 7 Q10713,P22695 2 +L27 domain superfamily [IPR036892] 0.8142365149684784 1.570318587834194 0.1163410119270598 1.0 0.4464468099965221 4 O14936,Q5T2T1 2 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.7301446380813224 1.5277463674808622 0.1265755229730487 1.0 0.4595665141790693 5 Q9UNN8 1 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.7301446380813224 1.5277463674808622 0.1265755229730487 1.0 0.4595665141790693 5 Q9UNN8 1 +Zinc finger, CCHC-type superfamily [IPR036875] 0.7940595017121457 1.491679306790839 0.1357832364440212 1.0 0.4729866243658894 4 Q9NUD5,Q16629 2 +RNA-binding domain superfamily [IPR035979] 0.4508927117199441 1.4749700437742002 0.1402205973141501 1.0 0.4744381500521783 133 Q9UKM9,Q92615,Q93062,P07910,Q14966,Q01844,P51991,P31943,P31942,Q99729,Q15233,Q96PK6,P98179,P18615,P35637,Q96I25,Q71RC2,P98175,O14979,Q08170,Q13243,Q13595,Q16630,Q5T8P6,Q8IUH3,P23588,P31483,O43390,Q12849,Q9UKA9,Q9P2K5,Q96T37,Q9NWH9,P09012,Q16629,P78332,P19338,P23246,P84103,Q9P2N5,Q9NTZ6,Q92804,Q8IY67,Q96E39,P22626,Q8WUA2,P33240,Q14011,O95104,Q76FK4,Q13242,Q8WXF1,Q9Y4C8,Q9Y6M1,Q9BWF3,Q8N684,O75494,P38159,P52597,Q92879,P09651,Q9BXP5,P55795,P62995,Q13151,Q9Y2U8,Q8WVV9,Q07955 68 +Six-bladed beta-propeller, TolB-like [IPR011042] 0.6965535109964544 1.3882322324783227 0.1650663402468077 1.0 0.5246553036800894 5 Q15165 1 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 0.4391386464779139 1.3558411718700585 0.1751497083493793 1.0 0.5343328661708061 132 Q9UKM9,Q92615,Q93062,P07910,Q14966,Q01844,P51991,P31943,P31942,Q99729,Q15233,Q96PK6,P98179,P18615,P35637,Q96I25,P98175,O14979,Q08170,Q13243,Q13595,Q16630,Q5T8P6,Q8IUH3,P23588,P31483,O43390,Q12849,Q9UKA9,Q9P2K5,Q96T37,Q9NWH9,P09012,Q16629,P78332,P19338,P23246,P84103,Q9P2N5,Q9NTZ6,Q92804,Q8IY67,Q96E39,P22626,Q8WUA2,P33240,Q14011,O95104,Q76FK4,Q13242,Q8WXF1,Q9Y4C8,Q9Y6M1,Q9BWF3,Q9H501,Q8N684,O75494,P38159,P52597,Q92879,P09651,P55795,P62995,Q13151,Q9Y2U8,Q8WVV9,Q07955 67 +Cytochrome P450 superfamily [IPR036396] 0.9008156606851486 1.3234891240659146 0.185672770751017 1.0 0.5540678926196432 2 Q16850 1 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.6442051057685698 1.2986772766902208 0.1940547054986492 1.0 0.5706780124321648 6 P09960,P55786 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.6442051057685698 1.2986772766902208 0.1940547054986492 1.0 0.5706780124321648 6 P09960,P55786 2 +Nucleotidyltransferase superfamily [IPR043519] 0.6421106419938616 1.2895393554488022 0.1972106434816316 1.0 0.5739933918210666 6 Q96SI9,Q96KR1 2 +BRCT domain superfamily [IPR036420] 0.556870351789629 1.2888335073596762 0.1974559743731032 1.0 0.5739933918210666 11 P09874 1 +Pseudouridine synthase, catalytic domain superfamily [IPR020103] 0.6717710244450456 1.2848911097177411 0.1988303380566618 1.0 0.5739933918210666 5 Q96PZ0,Q6P087 2 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.7333076035851054 1.253850056700132 0.2098965109480959 1.0 0.587959365979236 4 Q99797,P42892 2 +LEM/LEM-like domain superfamily [IPR011015] 0.6063336213557593 1.1333771016769072 0.2570559258642628 1.0 0.6617212794115668 6 Q86XL3 1 +Phosphoglycolate phosphatase-like, domain 2 [IPR023198] 0.8518760195758472 1.1312279926809048 0.2579591428214582 1.0 0.6617212794115668 2 P34913 1 +Haem oxygenase-like, multi-helical [IPR016084] 0.8456769983686712 1.107093228698164 0.2682536228221956 1.0 0.6716419878958945 2 P30519 1 +Cupredoxin [IPR008972] 0.8375203915171203 1.0754385702542917 0.2821784212033038 1.0 0.6914156533158149 2 P98172 1 +NAD(P)-binding domain superfamily [IPR036291] 0.3445385244749514 1.0343789733905664 0.3009590302633842 1.0 0.6997668092823515 70 Q06136,Q9NRG7,Q8NBX0,Q99536,Q14914,Q8N8N7,Q8N4Q0 7 +Chaperone J-domain superfamily [IPR036869] 0.4519212911214202 1.0036157120443012 0.3155638783036809 1.0 0.7021823462952187 16 Q96EY1,Q13217,O14976,Q99543,Q8IXB1 5 +Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866] 0.5732161700565803 0.9893640932822744 0.3224850357906805 1.0 0.7021823462952187 6 Q68D91 1 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.5366888338536768 0.9886685022615356 0.3228253583603018 1.0 0.7021823462952187 8 Q01844,P35637,P98175,Q92804 4 +Rho GTPase activation protein [IPR008936] 0.5112779777176636 0.979342764664159 0.3274106469704718 1.0 0.7080368963601745 10 Q9H0H5,O15031,Q07960,O00459 4 +Ribokinase-like [IPR029056] 0.8009138381201266 0.906941902574276 0.3644375208532329 1.0 0.7382596988958194 3 P55263,Q9BRR6 2 +Endonuclease/exonuclease/phosphatase superfamily [IPR036691] 0.7957763869563245 0.8892527372695787 0.3738672658064192 1.0 0.7414225941956204 3 Q6L8Q7 1 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.5731670888239544 0.876199541267322 0.3809215658738092 1.0 0.7414225941956204 5 P16615,P35670,Q9HD20 3 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.5731670888239544 0.876199541267322 0.3809215658738092 1.0 0.7414225941956204 5 P16615,P35670,Q9HD20 3 +P-type ATPase, A domain superfamily [IPR008250] 0.5731670888239544 0.876199541267322 0.3809215658738092 1.0 0.7414225941956204 5 P16615,P35670,Q9HD20 3 +ANL, N-terminal domain [IPR042099] 0.4997485309471545 0.7798176179608532 0.435498234709994 1.0 0.7934435791472062 7 P33121 1 +NET domain superfamily [IPR038336] 0.7494290375203784 0.7449628369426874 0.4562941863809333 1.0 0.8055801779686208 2 P25440 1 +Kinesin motor domain superfamily [IPR036961] 0.3960192880590055 0.7235366646938928 0.4693502368037092 1.0 0.8120208977765092 19 O00139,O95239,O00159,P35579,Q9Y4I1,Q7Z406,P33176,Q99661,P35580,Q8NI77 10 +HAD-like superfamily [IPR036412] 0.3932664700616967 0.7067721503967834 0.4797080840567918 1.0 0.81606950035565 19 P34913,Q9HD20,Q08623,Q969T7,Q86UY8 5 +HAD superfamily [IPR023214] 0.3932664700616967 0.7067721503967834 0.4797080840567918 1.0 0.81606950035565 19 P34913,Q9HD20,Q08623,Q969T7,Q86UY8 5 +Zinc finger C2H2 superfamily [IPR036236] 0.3882300974976642 0.696923853422285 0.4858504489647324 1.0 0.8161239525962994 20 Q9Y2X9,Q96JM3,Q96ME7,Q14966,O60870,Q92766,Q92785,Q969S3,Q9NRM2,Q96KR1,Q15428 11 +SH3-like domain superfamily [IPR036028] 0.3733081296817689 0.6894172280454473 0.4905607449243305 1.0 0.817052430370509 32 P07948,O00459,O14936,Q92796,Q8N5V2,Q14168,Q9UQB8,Q92783,Q5T2T1 9 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.7061233947878158 0.5946056329153929 0.5521071139042415 1.0 0.858091920370028 3 Q96EY1 1 +Lamin tail domain superfamily [IPR036415] 0.7013707571801684 0.5799652241913932 0.5619380694440175 1.0 0.8589157047338305 3 P20700,Q03252 2 +Band 7/SPFH domain superfamily [IPR036013] 0.4433701316784642 0.568121054126573 0.5699527724802462 1.0 0.8589157047338305 8 O75955,Q9UJZ1,P27105,O75477 4 +Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080] 0.3966749189874516 0.5389634401276192 0.5899120814134216 1.0 0.8674096648820404 12 Q9HA77,Q9NSE4,Q96GW9 3 +ENTH/VHS [IPR008942] 0.3687567612145731 0.5153099875164857 0.6063364208699589 1.0 0.8751572627154491 14 O00291,Q9NQG5,Q9UJY4,Q9Y6I3,Q92783,O95104 6 +SNARE [IPR010989] 0.4578163036502735 0.5118383463259534 0.6087641505021704 1.0 0.8751572627154491 6 Q86Y82 1 +Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008] 0.456979245343627 0.50864702346371 0.6109996619909666 1.0 0.8751572627154491 6 Q9NSE4 1 +HRDC-like superfamily [IPR010997] 0.6753670473083153 0.4954664751550441 0.6202708810182225 1.0 0.8823912725454122 2 Q01780 1 +B30.2/SPRY domain superfamily [IPR043136] 0.3886521680806763 0.4540640040404323 0.6497827604635873 1.0 0.8906836592010605 11 P19474,Q9BUJ2,Q96S59,Q12899 4 +FF domain superfamily [IPR036517] 0.6610114192495866 0.4517237476205342 0.6514680081351587 1.0 0.8906836592010605 2 O75400 1 +Ankyrin repeat-containing domain superfamily [IPR036770] 0.3522251407242701 0.4326464383166803 0.6652716471506361 1.0 0.8960553805935406 14 Q86XL3 1 +EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044] 0.6388254486133695 0.3877937180822051 0.6981686947021513 1.0 0.9128410634332836 2 Q6NUQ1 1 +ISWI, HAND domain superfamily [IPR036306] 0.630995106035881 0.3663771330663944 0.7140836804818271 1.0 0.9141752066034696 2 P28370 1 +Bromo adjacent homology (BAH) domain superfamily [IPR043151] 0.4840592174182082 0.355283644595475 0.7223771069933402 1.0 0.9165645013463888 4 Q13330 1 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.6178065452158072 0.3467846464101974 0.7287531125874804 1.0 0.9183559870687388 3 Q99797 1 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.6202283849918344 0.3379676282008447 0.7353875828156511 1.0 0.918962489538878 2 P35611 1 +Peptidyl-tRNA hydrolase II domain superfamily [IPR023476] 0.6052202283849818 0.3004619332024539 0.7638248286579723 1.0 0.9401073151234124 2 Q9Y3E5 1 +Pyridoxal phosphate-dependent transferase [IPR015424] 0.3356796778750011 0.2720682186581553 0.7855695659282034 1.0 0.9401073151234124 12 O75600,Q6P996 2 +Pyridoxal phosphate-dependent transferase, major domain [IPR015421] 0.3356796778750011 0.2720682186581553 0.7855695659282034 1.0 0.9401073151234124 12 O75600,Q6P996 2 +Winged helix-like DNA-binding domain superfamily [IPR036388] 0.3081824458141138 0.2697298341735814 0.7873681065937592 1.0 0.9401073151234124 46 Q92615,P10412,P85037,P29084,Q9BRG1,P07305,O75381,P16402,P16403,Q96HY6,Q8NB78,Q71RC2 12 +HSP40/DnaJ peptide-binding [IPR008971] 0.4519942438690896 0.2690435471367235 0.7878961719178337 1.0 0.9401073151234124 4 Q96EY1 1 +Histone-fold [IPR009072] 0.3629868048798049 0.2418648553762591 0.8088848830586175 1.0 0.95136192131573 7 P84243 1 +LDL receptor-like superfamily [IPR036055] 0.5791190864600205 0.2413778062848366 0.8092623123056475 1.0 0.95136192131573 2 Q07954 1 +HR1 repeat superfamily [IPR036274] 0.567373572593788 0.2174447530164533 0.827861757558547 1.0 0.9659691874929972 2 Q16512 1 +Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091] 0.4296441397322942 0.2161758467222755 0.8288506799463218 1.0 0.9659691874929972 4 P18754,Q9P258,O95071 3 +CAP Gly-rich domain superfamily [IPR036859] 0.5352912112466139 0.1760019953123264 0.860292374885447 1.0 0.977489312429334 3 Q99426 1 +14-3-3 domain superfamily [IPR036815] 0.3511924207775224 0.1695940073191553 0.8653294357436558 1.0 0.977489312429334 6 P62258,Q04917,P63104,P61981,P31946 5 +SMCs flexible hinge superfamily [IPR036277] 0.3574138645737312 0.1559084678115015 0.876105170586194 1.0 0.9790443710488096 5 Q9UQE7,Q9NTJ3,Q14683 3 +Mss4-like superfamily [IPR011057] 0.5246329526916699 0.1446781273662762 0.8849650092715164 1.0 0.9839893624879994 2 P13693 1 +SMAD/FHA domain superfamily [IPR008984] 0.3097379652587735 0.1343876002489331 0.893096086259606 1.0 0.9890791342935172 10 P85037 1 +PABC (PABP) domain [IPR036053] 0.5052219321148779 0.1313285193219463 0.8955154320098766 1.0 0.9890791342935172 3 P11940,O95071 2 +R3H domain superfamily [IPR036867] 0.5029373368146177 0.1283255679731745 0.8978913320627195 1.0 0.9896566742021116 3 O15226,O95453 2 +Chromo-like domain superfamily [IPR016197] 0.3072324389365464 0.1276210034792905 0.8984489086771288 1.0 0.9896566742021116 10 P45973,Q12873,Q9UBU8 3 +SNF2-like, N-terminal domain superfamily [IPR038718] 0.2781457206491616 0.1201637456813592 0.9043534363854926 1.0 0.9916316601776972 17 P46100 1 +Growth factor receptor cysteine-rich domain superfamily [IPR009030] 0.5060358890701289 0.1199657149098126 0.904510307306262 1.0 0.9916316601776972 2 Q07954 1 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.4934725848563887 0.1164638422774844 0.9072849407324892 1.0 0.9916316601776972 3 P53609,P48449 2 +DUSP-like superfamily [IPR035927] 0.490701468189215 0.1026124031285959 0.9182705985333012 1.0 0.9952324282611208 2 Q86UV5 1 +Myosin S1 fragment, N-terminal [IPR008989] 0.3633788497730846 0.0984555705569217 0.9215705500505716 1.0 0.9976635312474076 4 Q7Z406,P35580 2 +Ribosomal L18e/L15P superfamily [IPR036227] 0.4663971746765928 0.0875371596532533 0.9302445496505208 1.0 1.0 3 Q07020 1 +Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978] 0.4525285481239748 0.070225949081842 0.944013820927284 1.0 1.0 2 Q9NP81 1 +Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103] 0.4525285481239748 0.070225949081842 0.944013820927284 1.0 1.0 2 Q9NP81 1 +Alpha-catenin/vinculin-like superfamily [IPR036723] 0.4402741514360207 0.0661932048309628 0.9472240066706812 1.0 1.0 3 P35221,Q9Y490 2 +Cyclic phosphodiesterase [IPR009097] 0.428711256117448 0.0567549840093358 0.9547403736568754 1.0 1.0 2 P09543 1 +RNA polymerase Rpb1, clamp domain superfamily [IPR044893] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 1.0 3 P24928,O14802 2 +RNA polymerase Rpb1, domain 3 superfamily [IPR042102] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 1.0 3 P24928,O14802 2 +RNA polymerase Rpb1, funnel domain superfamily [IPR038120] 0.4187336814621448 0.0528989471906747 0.9578124232437242 1.0 1.0 3 P24928,O14802 2 +Prefoldin [IPR009053] 0.2849957048004752 0.0458809381196875 0.9634051473523816 1.0 1.0 6 Q9UBK9 1 +Ribosomal protein L10-like domain superfamily [IPR043141] 0.3941038385675325 0.0417587983838144 0.966690980469167 1.0 1.0 3 Q7Z7H8 1 +PPM-type phosphatase domain superfamily [IPR036457] 0.3035537893320391 0.0412391223045234 0.9671052650981852 1.0 1.0 4 Q15750 1 +PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946] 0.3582381729200622 0.0375414932730314 0.9700532566020664 1.0 1.0 2 P19174 1 +RNA polymerase Rpb2, OB-fold [IPR014724] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 1.0 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 2 superfamily [IPR037034] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 1.0 2 Q9H9Y6 1 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033] 0.338662316476347 0.0355918953992661 0.971607770763375 1.0 1.0 2 Q9H9Y6 1 +Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037] 0.291027732463296 0.0335480082714198 0.9732375822933046 1.0 1.0 2 Q10567 1 +GTP-binding protein, orthogonal bundle domain superfamily [IPR023179] 0.2835236541598686 0.0334221633197253 0.9733379357607654 1.0 1.0 2 Q13823 1 +Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014] 0.2786296900489415 0.0333562205518131 0.973390521156896 1.0 1.0 2 P11177 1 +Thioredoxin-like superfamily [IPR036249] 0.2672633455189896 0.0328418387960731 0.9738007136597588 1.0 1.0 49 P30101,Q96JJ7,Q8NBS9,Q13162,P07237,O43678,Q6ZRP7,Q15084,Q9H3N1,O43396,Q8IXB1,O95881,Q9H7Z7,P13667 14 +SCP2 sterol-binding domain superfamily [IPR036527] 0.3247389033942601 0.0267094221146743 0.97869149805369 1.0 1.0 3 Q6YN16,P51659 2 +EF-hand domain pair [IPR011992] 0.2626046941291456 0.0037938133089734 0.9969729821955244 1.0 1.0 46 Q9NWM8,Q14257,P80303 3 +K Homology domain, type 1 superfamily [IPR036612] 0.2424064979405942 0.001069320110842 0.9991468061556 1.0 1.0 25 P61978,Q96AE4,O75525,Q13868,P51116,Q92945,Q96I24,Q92667 8 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a59a331d96e5f3950b2363342c2f0ba366a37141 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily [IPR036971]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "5-formyltetrahydrofolate cyclo-ligase-like domain superfamily [IPR024185]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "APC, N-terminal coiled-coil domain superfamily [IPR036149]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit A superfamily [IPR035908]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Actin-related protein 2/3 complex subunit 5 superfamily [IPR036743]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adenomatous polyposis coli protein [IPR026831]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-dystroglycan domain 2 [IPR027468]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Bcr-Abl oncoprotein oligomerisation domain superfamily [IPR036481]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CENP-B, dimerisation domain superfamily [IPR034882]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carbon-nitrogen hydrolase superfamily [IPR036526]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cation efflux transmembrane domain superfamily [IPR027469]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Core-binding factor, beta subunit superfamily [IPR036552]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily [IPR037008]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA glycosylase [IPR011257]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, subunit B, N-terminal domain superfamily [IPR043034]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Daxx, N-terminal domain superfamily [IPR038298]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Dedicator of cytokinesis, N-terminal, subdomain 1 [IPR042455]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "ESCRT-II complex, Vps25 subunit, N-terminal winged helix [IPR014041]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exocyst component Exo84, C-terminal, subdomain 1 [IPR042561]", "Exocyst component Exo84, C-terminal, subdomain 2 [IPR042560]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Fe-S cluster assembly domain superfamily [IPR034904]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP cyclohydrolase 1 type 2/Nif3 superfamily [IPR036069]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Globular protein, non-globular alpha/beta subunit [IPR011070]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase-type carbohydrate-binding [IPR014718]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix-hairpin-helix, base-excision DNA repair, C-terminal [IPR023170]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "LysM domain superfamily [IPR036779]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial ribosomal protein L55 superfamily [IPR044884]", "MoaB/Mog-like domain superfamily [IPR036425]", "Moesin tail domain superfamily [IPR008954]", "Mog1/PsbP, alpha/beta/alpha sandwich [IPR016123]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Ndc80 domain superfamily [IPR038273]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nuclear hormone receptor-like domain superfamily [IPR035500]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAS domain superfamily [IPR035965]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PINIT domain superfamily [IPR038654]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PLP-binding barrel [IPR029066]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Plus3-like superfamily [IPR036128]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinolinate phosphoribosyl transferase, N-terminal domain superfamily [IPR037128]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RRF superfamily [IPR036191]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Rad4, beta-hairpin domain 3 superfamily [IPR042488]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rel homology domain (RHD), DNA-binding domain superfamily [IPR037059]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S16 domain superfamily [IPR023803]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S18 superfamily [IPR036870]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rudiment single hybrid motif [IPR011054]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SAP30, C-terminal domain superfamily [IPR038291]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scaffold protein Nfu/NifU, N-terminal domain superfamily [IPR036498]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/glucose symporter superfamily [IPR038377]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Sodium:neurotransmitter symporter superfamily [IPR037272]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfatase-modifying factor enzyme superfamily [IPR042095]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Telomere repeat-binding factor, dimerisation domain superfamily [IPR036507]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription factor IIA, beta-barrel [IPR009088]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transglutaminase-like superfamily [IPR036985]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 [IPR042522]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 [IPR042523]", "Ufd1-like, Nn domain [IPR042299]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vta1/Callose synthase, N-terminal domain superfamily [IPR023175]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATR", "ATRX", "ATXN10", "AURKB", "BABAM1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAS3", "BCAT2", "BCKDHA", "BCKDK", "BCL2L13", "BCR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BZW1", "BZW2", "C1QBP", "C2CD2", "CAB39", "CABIN1", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPV", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "COA7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCPS", "DCTN1", "DCUN1D1", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM120A", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOPC", "GORASP2", "GOT1", "GOT2", "GPD1L", "GPD2", "GPI", "GPKOW", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCFC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INF2", "INTS1", "INTS12", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "L2HGDH", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "METAP1", "METTL1", "METTL13", "METTL17", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIF", "MIF4GD", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPG", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL4", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL55", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYBBP1A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCBP3", "NCDN", "NCL", "NCOA5", "NDC80", "NDRG3", "NDUFA10", "NDUFA2", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFE", "NENF", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKB", "PIAS2", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLEKHA5", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POMGNT2", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP12", "RRP7A", "RRP8", "RRP9", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTN4IP1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX12", "STX17", "STX3", "STX4", "STX5", "STX7", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFRC", "THEM6", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMA16", "TMED5", "TMED7", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSPO", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS13D", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WNK1", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFC3H1", "ZFR", "ZFYVE16", "ZMYND8", "ZNF277", "ZNF281", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZPR1"], "leading_proteins": ["ABCB1", "ABCC4", "ABHD10", "ACOX3", "ACSL1", "ADD1", "ADK", "ADNP", "ADPGK", "AIFM1", "AKAP1", "ALDH1A2", "ANKLE2", "ANXA11", "ANXA4", "ANXA7", "AP1B1", "ARHGAP1", "ATP13A1", "ATP2A2", "ATP7B", "ATRX", "AURKB", "BAIAP2", "BRD2", "CARS2", "CASK", "CBX5", "CDC5L", "CDK1", "CDK11B", "CDK13", "CDK2", "CELF1", "CERS2", "CHAMP1", "CHD3", "CIRBP", "CLUH", "CNP", "COQ8A", "CPSF6", "CPSF7", "CRTAP", "CSTF2", "CTNNA1", "CYB5D2", "CYP51A1", "DDRGK1", "DLG3", "DNAJA3", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DPF2", "ECE1", "EFNB1", "EIF4B", "EPHX1", "EPHX2", "EPN1", "ERLIN1", "ESF1", "EWSR1", "EXOSC10", "EXOSC2", "FKBP14", "FLOT1", "FN3KRP", "FOXK1", "FUBP1", "FUBP3", "FUS", "FXR2", "GAK", "GCAT", "GET4", "GGA2", "GNL2", "GRSF1", "GSK3A", "GSK3B", "GTF2E2", "H1F0", "H3-3A*", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPLL", "HNRNPR", "HNRNPUL1", "HSD17B4", "HSDL2", "IARS2", "IGF2BP2", "KDM1B", "KDSR", "KHDRBS3", "KHSRP", "KIAA0391", "KIF18A", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIN", "KLC4", "LARP4", "LARP4B", "LCOR", "LEMD3", "LMNB1", "LMNB2", "LRP1", "LSS", "LTA4H", "LYN", "MARS2", "MBLAC2", "MFSD10", "MFSD5", "MIPEP", "MORF4L1", "MPP2", "MPP7", "MRPL10", "MTA1", "MYEF2", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO5A", "NCL", "NDUFA2", "NELFE", "NENF", "NGEF", "NKRF", "NOL8", "NONO", "NPEPPS", "NT5C3B", "NT5DC3", "NUCB2", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PARN", "PARP1", "PCYOX1", "PDE12", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDXDC1", "PEX14", "PGGT1B", "PGRMC2", "PIK3R2", "PKN1", "PLA2G15", "PLCG1", "PLK1", "PLXNB2", "PMPCA", "POLR1B", "POLR2A", "POLR3A", "PON2", "PPIL4", "PPT2", "PRCP", "PRDX4", "PREPL", "PRKCA", "PROCR", "PRPF40A", "PSMB2", "PSMB4", "PSMB7", "PSPC1", "PTBP2", "PTGES2", "PTGR1", "PTGR2", "PTRH2", "PUDP", "PUS7", "QSOX2", "RACGAP1", "RALY", "RANBP9", "RAVER1", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM26", "RBM27", "RBM3", "RBM4", "RBM45", "RBM6", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCN2", "RINT1", "ROCK1", "RPL18", "RPRD1B", "RPUSD3", "RREB1", "SARS2", "SCAF4", "SCCPDH", "SCPEP1", "SDR39U1", "SF3A2", "SFPQ", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A20", "SLC25A21", "SLC25A26", "SLC29A1", "SLTM", "SMARCA1", "SMARCC2", "SMC1A", "SMC3", "SMC4", "SNRPA", "SPNS1", "SRRT", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "STAM", "STOM", "STOML2", "STRBP", "STX12", "TAB1", "TAF15", "TBCB", "TERF2IP", "TIA1", "TLN1", "TMX1", "TMX3", "TPT1", "TRA2A", "TRA2B", "TRIM21", "TRIM26", "TTC19", "TTC38", "TXNDC12", "TXNDC5", "TXNL1", "UBR5", "UQCRC2", "USP48", "UXT", "VAT1", "VPS25", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2", "ZCCHC3", "ZFR", "ZNF277", "ZNF281", "ZNF512", "ZNF622", "ZNF638"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5757f82df3ff72d58188cea7e468f9ee88778460 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ad0b56be4966bd7fa0adc6d939ff6305e45a996921a3681ff2e02e1d6468c353 +size 67928 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0e9df26c81aabb3f9476a49e652e8eefa226146e --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.25 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..132d496a8448096f196f7681487615e71800653b --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c1a038d8f4892dbce720240443e15002c0070b35 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.5731670888239544 0.876199541267322 0.3809215658738092 0.8531132229587624 0.5078954211650789 5 P16615,P35670,Q9HD20 3 +EGF-type aspartate/asparagine hydroxylation site [IPR000152] 0.660358890701463 0.4497781081461503 0.6528704445548263 0.9854800082873324 0.6528704445548263 2 Q07954 1 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..dca87f3956a315b25be4be978b33907cbe27a8ad --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP7B", "EIF5A", "FASN", "LRP1", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP2A2", "ATP7B", "LRP1"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..c06b6ea663e54c23bbacc21e8348df4d2f7cfbbf --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bf942f658a2338e13f707b3bb7154351b2f491613e6d6d31c524b62febdd1f1f +size 75189 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..27a40df55c0233948725dd4098624253bf5ccad2 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Annexin repeat [IPR018502] 3 6 2.449812039910771 0.0142930804496084 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 0.075113296023457 2.1797401302891516e-05 0.0003286021100258 +Mitochondrial substrate/solute carrier [IPR018108] 3 18 2.220733469915304 0.0263690190754262 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 0.1675604235637086 0.0523352985295366 0.0130060888805635 0.0353817250131281 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b483f1990aefb8e0369814977b28a9ec4baa1745 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 76, + "title": "Average number of proteins per term", + "value": 5.302631578947368 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a9fef959904ff5e3cbebf1898fc6420708ff263a --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ee87fe5ea43643503155671aafb44e4d0d28f887 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,7 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Annexin repeat [IPR018502] 0.9192687687169844 2.449812039910771 0.0142930804496084 0.6651631867251648 0.1936120672374262 6 P20073,P09525,P50995 3 +Mitochondrial substrate/solute carrier [IPR018108] 0.6445137598457216 2.220733469915304 0.0263690190754262 0.8687880964128932 0.2018314299155124 18 Q9BQT8,Q70HW3,O43772 3 +Pentatricopeptide repeat [IPR002885] 0.6842053832895472 1.062067965621282 0.2882048316205652 0.9999999999939884 0.6084324223100821 4 Q96EY7,Q92552 2 +Low-density lipoprotein (LDL) receptor class A repeat [IPR002172] 0.5791190864600205 0.2413778062848366 0.8092623123056475 1.0 0.8975813177257451 2 Q07954 1 +PFTB repeat [IPR001330] 0.4933115823817103 0.105379443164308 0.9160747272111394 1.0 0.9537216338088574 2 P53609 1 +Regulator of chromosome condensation, RCC1 [IPR000408] 0.4295039164490934 0.0590947568186731 0.95287663479789 1.0 0.9655816565951952 3 P18754,Q9P258 2 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3612900bdc602d3c796524addecf2118485e2ea3 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Adenomatous polyposis coli (APC) repeat [IPR041257]", "Adenomatous polyposis coli protein repeat [IPR009223]", "Adenomatous polyposis coli protein, 15 residue repeat [IPR009240]", "Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "BspA type Leucine rich repeat region [IPR026906]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "SAMP [IPR009224]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN4", "AGAP3", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "APC", "ARMC6", "ARMCX3", "ARPC1A", "ARPC1B", "ARVCF", "ASPH", "ATR", "BIRC6", "BOP1", "BRAT1", "BUB3", "CABIN1", "CAST", "CDC16", "CDC23", "CDC27", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "COA7", "COLEC12", "COPA", "COPB2", "CORO1B", "CORO1C", "CORO7", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DYNC1I2", "EDC4", "EED", "EHMT1", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "ERBIN", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GMPPB", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HTT", "HUWE1", "IGF2R", "IPO4", "IPO5", "JUP", "KAT7", "KDELC2", "KDM2A", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LARP1", "LASP1", "LLGL1", "LRBA", "LRCH2", "LRP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MKI67", "MRPS27", "MTCH1", "MTCH2", "MTPN", "NAA15", "NASP", "NEK9", "NFKB2", "NHLRC2", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NUDT12", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "P4HA1", "P4HA2", "PAFAH1B1", "PAK1IP1", "PDCD11", "PGGT1B", "PHIP", "PIK3R4", "PLAA", "PLEC", "PLRG1", "PLXNB2", "POLR2A", "PPID", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP5C", "PPWD1", "PREB", "PRKCSH", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABGGTA", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RBBP5", "RCC1", "RCC2", "RNH1", "RPAP3", "RPTOR", "RRP9", "RSU1", "SART3", "SCML2", "SCRIB", "SEC13", "SEC31A", "SGTA", "SHOC2", "SIN3A", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", 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0.7765678108992397 0.4273021352291809 2.482119818897232 1.8660787070180411 0.9906439819977368 0.3285418073460514 0.0007067870165067 0.0001966568602221 0.0015498580582828 0.0002335266734922 0.0001024209024739 +Intracellular protein transmembrane transport 4 21 2.5725024554970046 0.0100966239710671 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 0.0024835792448883 0.0012844156650938 0.0093807730237194 0.0044406378118471 0.0655768501043339 +Mitochondrial transmembrane transport 11 52 2.556477265015283 0.0105737980471327 19.070388349514563 50.63834951456311 1.9310146760091371 0.188342667216329 9.760351579527285 3.939196260509299 1.9786128158557912 0.3017981993827387 0.0086122347094551 5.111567422339664e-05 0.0001694771292921 0.0010205325993841 0.0007767330813302 +Regulation of blood pressure 3 18 2.528012406090354 0.0114710298499649 5.762135922330097 17.737864077669904 1.3077123393993415 0.1882731913471478 2.2751770017499977 2.3871059987956724 1.372929386780725 0.2480453688154592 0.0924957985250946 0.0315268496209905 0.0186371594327644 0.0515621560092188 0.0611543838186325 +Organic acid transport 12 46 2.527021298852534 0.0115034526178441 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 0.2055881744359427 0.0278996799404129 0.000361145841306 2.6804136541097984e-05 0.0009643504563797 +Cardiocyte differentiation 2 18 2.518895440829287 0.0117723609489601 4.783980582524272 20.555825242718445 -0.1933321898036617 0.6337345178032765 3.2056436397787618 2.5148664865531227 0.7257554569703125 0.2805146302624514 0.0084178166544246 0.0614819278885333 0.0481208533269518 0.3328871795746319 0.5876151243269294 +Negative regulation of mrna splicing via spliceosome 6 15 2.480428052603946 0.0131224743481215 6.087378640776699 15.199029126213592 0.1078323316448317 0.4870213286066137 2.88823121239329 1.0677073837920623 1.2108018519405566 0.3438522963849697 1.0 1.0 1.0 0.0102137155300364 1.8433829013364647e-05 +Chromosome condensation 8 23 2.475153578067778 0.0133178893050649 8.347087378640778 24.398058252427184 -0.81785765326126 0.4024287790270713 3.6713818808038847 1.899615729282307 1.1192710525415783 0.3308896927741966 0.0599777160833937 0.0135379522122687 0.0054315442599267 0.0118572988629309 0.0003233683313873 +Pancreas development 2 9 2.47439036910402 0.0133463775765614 2.6990291262135924 10.361650485436892 0.0442216002088525 0.5908002352036736 1.997984185367068 2.029583436664593 0.8036544387417133 0.2790166714066305 0.0755969254037073 0.0014578554854327 0.0105712178095962 0.1048323445251165 0.4011073361813396 +Positive regulation of dna dependent dna replication 1 6 2.47134969652439 0.0134604121332728 2.104368932038835 5.308252427184466 -0.0451029964534636 0.5304800246160674 1.3260937379209767 1.085933831223192 0.9590241497998035 0.3064788302511712 0.0231057649354089 0.0652597674910206 0.0078714328443906 0.0439142352380576 0.1457988469723397 +Meiosis i cell cycle process 3 16 2.4660619723526964 0.0136607696897885 4.424757281553398 19.196601941747577 0.2772784498983839 0.6314315125632272 2.807180233511531 3.286141554662213 0.6809152194023591 0.283244242032616 0.1150715625874215 0.297366720714231 0.0338721796728873 0.1005919349614823 0.2803163600559855 +Endocrine system development 3 12 2.4637187945467622 0.0137503943789845 3.3737864077669903 11.881067961165048 -0.2081330314663085 0.5365709083813949 2.252526571292414 2.477653686756441 0.8827761558251624 0.2829142263578424 0.1150715625874215 0.0051240399378157 0.0054554424478239 0.1005919349614823 0.4761273938714457 +Cardiac cell development 2 11 2.459179249382027 0.013925507023391 2.558252427184466 13.03883495145631 0.2336456004918237 0.6593263993462724 2.2563835775199825 2.0117245178865257 0.6297385778454329 0.2665390312599383 0.0025939276716256 0.0204708743585679 0.0099655953739765 0.0998367022916053 0.1829577777968287 +Carbohydrate derivative transport 4 19 2.4561502679467258 0.0140434420939028 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 1.0 0.0204708743585679 0.0099655953739765 0.0048857385669874 0.0228888281479028 +Negative regulation of mrna processing 8 21 2.444577475964376 0.0145021928849304 7.699029126213592 21.66747572815534 0.1748680804835885 0.5472984180526073 3.879457852865703 1.8456483684321656 1.0884740123370542 0.3440194219213014 1.0 1.0 1.0 0.0294507732567689 3.828861199610836e-05 +Fatty acid transport 5 15 2.417047731255048 0.0156469651702453 4.405339805825243 16.594660194174757 0.9956425124175664 0.363449355794835 2.458050105556273 1.867782713051167 0.7812672834370499 0.2834143639149277 1.0 0.1755724648168266 0.0573531962335191 0.0026376358858749 0.0119603409362114 +Determination of adult lifespan 1 7 2.396588326758784 0.0165485044888835 1.4684466019417477 6.878640776699029 0.9172678211727472 0.3356532972350567 1.327993783820954 0.8617154358126836 0.9778379941999832 0.290947936133699 1.0 1.0 0.0078714328443906 0.0439142352380576 0.1457988469723397 +Organic cation transport 2 6 2.3938329589413585 0.0166733402991181 2.191747572815534 5.524271844660194 1.626219676916526 0.1372808582950073 1.481153399412497 1.209546654977186 0.871004228766265 0.1892257790071234 1.0 0.0963063052639835 0.0173819675279631 0.0135296171343662 0.0790607116166092 +Negative regulation of rna splicing 7 17 2.367699208339752 0.0178990812405923 6.550970873786408 17.652912621359224 0.080708148531743 0.5352211753198439 3.085327637418694 1.454292695708865 1.0888581549716274 0.3350559056430555 1.0 1.0 1.0 0.0195244436529747 1.0761884384293304e-05 +Negative regulation of cell development 3 19 2.3637041668735224 0.0180932540833436 4.842233009708738 22.570388349514563 0.359297279383123 0.4985276743183016 2.6202836250687755 3.2526907225500694 0.942582430028218 0.3017948582790589 0.1457909390965756 0.0748187401998431 0.0131034302652722 0.1935096580394825 0.6759251568781421 +Cellular response to reactive nitrogen species 1 7 2.358977730996098 0.0183253554151252 2.1650485436893203 7.007281553398058 0.704490730091036 0.4621610896845695 1.550741052909057 1.0369135438534465 0.8122040116731231 0.3119296534732217 0.0231057649354089 0.001984476440523 0.0078714328443906 0.0439142352380576 0.1457988469723397 +Response to nitric oxide 1 7 2.358977730996098 0.0183253554151252 2.1966019417475726 7.133495145631068 0.679168344832026 0.4714973348756168 1.5773543373723289 1.1316902117688077 0.8115312793316939 0.314104254155695 0.0231057649354089 0.001984476440523 0.0078714328443906 0.0439142352380576 0.1457988469723397 +Multicellular organism aging 1 11 2.358749258237634 0.0183366407845813 2.1674757281553396 10.37864077669903 0.7123407673681669 0.4042486598886041 1.8218230592238136 1.366140512569931 0.923721768654342 0.2985518072202843 1.0 1.0 0.0173819675279631 0.090818300458346 0.2715157705871365 +Muscle cell development 3 26 2.3556537148515035 0.0184901452690251 6.330097087378641 28.67233009708738 0.2691494831837144 0.6827929696500872 3.5434565690288147 2.923276424850113 0.6250704768878858 0.2873694003988631 0.0108829135912739 0.0775893010402436 0.0664874170634557 0.2034802009295251 0.3228825183846249 +External encapsulating structure organization 5 28 2.352338040492467 0.0186558121017892 6.233009708737864 24.611650485436893 0.4933150664413553 0.5761144283300919 2.7919923063541368 3.9981379396708774 0.7808928343017973 0.3215391690746272 0.0161247158153836 0.0189208145590584 0.1070377409089595 0.1582163702578203 0.3487816152309713 +Alcohol metabolic process 17 75 2.3361122274548736 0.0194853931989311 19.300970873786408 81.99029126213593 1.0392616248309592 0.3936245775900834 6.9548962308345 7.403089286448431 1.208378917036781 0.3759976884392474 1.0 0.0787455373115164 0.0041652078686871 0.000556269116731 0.0062789268380777 +Positive regulation of mitochondrion organization 6 22 2.3292771035238884 0.0198443905367018 6.235436893203883 22.393203883495147 0.6669540243221574 0.4355223453199826 2.7589935116766484 2.962672702300372 1.01251720769805 0.3295170825531805 0.0848508607107458 0.0266825716175236 0.0146485330026984 0.1367305798708485 0.0135499856307104 +Appendage development 3 11 2.329183014981975 0.0198493723233366 3.283980582524272 15.37621359223301 0.1480909574057644 0.5969421392568955 2.39526954512383 3.7053775187314058 0.7995041457403814 0.2918586249779653 1.0 0.4517357114503159 0.1194557751624266 0.5818026208924209 0.858745979078654 +Positive regulation of ubiquitin dependent protein catabolic process 4 23 2.3279012521740885 0.0199173477535341 7.834951456310679 29.453883495145632 -0.0313652091322198 0.6857531694335371 3.9996288356404057 3.883661252515557 0.7001302383734394 0.285210658038083 0.1268947769971692 0.0576595399457578 0.0078630589925165 0.04644869055857 0.3574963066401728 +Vitamin transmembrane transport 1 6 2.3131516894347297 0.0207143006364125 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 1.0 0.0022827689145391 0.0090253131212995 0.0498779046475234 0.1630814235328921 +Negative regulation of cell cycle process 14 70 2.3024979919129684 0.0213071045373076 22.808252427184467 75.67233009708738 -0.4152152454806342 0.6120337990781597 9.341401209542374 10.519603125139913 0.7619945115612721 0.3197727993859293 0.055596637996667 0.3052095683601886 0.0247865178565085 0.0040878244038074 0.0572936354603499 +Organophosphate ester transport 5 29 2.2966278840494314 0.021640006566153 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.1239529915806494 0.0063852408669871 0.0072060328618288 0.0121231126733016 0.0882575787179951 +Response to toxic substance 6 48 2.2891397520195595 0.0220712337856217 10.449029126213592 47.61893203883495 0.2471625961982644 0.5593010307435107 5.121800353706628 3.557152076914045 0.9585220287488015 0.3332680862055938 0.0010540128752913 0.0003049515292831 0.0001958198191329 0.0309649911309741 0.0070808880000234 +Regulation of dna dependent dna replication 2 20 2.2831264967675966 0.0224229181931494 4.526699029126213 20.218446601941743 0.0665516527406215 0.7310548028391746 3.329300019246448 2.507435450497337 0.584345409578159 0.2641663558866737 0.0786913117941895 0.2107016729382093 0.0118453859760714 0.1151104414767163 0.427430123643528 +Vitamin transport 1 7 2.275671767073153 0.0228656623722738 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 1.0 0.0058373227860703 0.0224191931510111 0.1139407547181512 0.32624452618512 +Appendage morphogenesis 3 9 2.2722451217361868 0.0230717093541616 2.733009708737864 12.356796116504857 0.1736162467757523 0.5679910710115588 2.1781299697112395 2.7670701317045303 0.8540375906091052 0.2978148567402963 1.0 0.3746890061856052 0.0681445056645133 0.4186732079295251 0.6997017670477774 +Peptidyl proline hydroxylation 5 7 2.2722401712833133 0.0230720081915776 2.9393203883495147 7.366504854368932 0.8317722887875127 0.3653030215718857 1.5036226559632782 0.8268224457358132 1.022007383809078 0.3112189596123257 0.0198359893050149 0.0014481500629001 0.0057815105752346 0.000142755965642 9.139729707100432e-06 +Organic hydroxy compound transport 10 31 2.264626383474558 0.0235356164672062 7.145631067961165 30.32766990291262 0.3121985122058121 0.5028073494895335 3.2773354290298986 4.4061862301676955 1.0194405540894098 0.3270691777029814 1.0 0.4101596343015291 0.0041085081840627 0.0012880971949662 0.0064766031801115 +Negative regulation of cell differentiation 5 67 2.264001740718494 0.0235740077154986 16.45631067961165 74.8495145631068 -0.1353149290741099 0.6688900030125019 8.66672769349464 8.561410075612406 0.7355667191532931 0.3072250429225737 0.4345387125305697 0.0771246218272949 0.1081815909586036 0.7106952393987453 0.9847884275786648 +Regulation of neuron differentiation 1 19 2.261404497321327 0.0237342205316868 5.286407766990291 20.160194174757283 -0.0173168065481275 0.5555762040934534 3.9079840740523073 2.6196731362780623 0.963059918132658 0.3115826074576115 1.0 0.0963497535154777 0.2858928639483155 0.7457734087268266 0.9047542689165794 +Regulation of systemic arterial blood pressure 2 6 2.25937905674728 0.0238598160260203 1.9514563106796117 7.480582524271845 0.6591644372092078 0.3227631999327531 1.1543807719023411 1.5318976272183211 1.1594175747176596 0.2663405748898474 0.0473038642381172 0.0084566179175882 0.0027014769688677 0.0322769586697076 0.1645088237572309 +Purine containing compound transmembrane transport 3 10 2.2563526357727945 0.0240485554066955 3.6432038834951457 8.228155339805825 0.8480777288434221 0.3004167480224937 2.0847056152178514 1.431742605530374 1.2278207398320582 0.2967021731271802 1.0 0.0652597674910206 0.0078714328443906 0.0002778449152815 0.0003671727016274 +Modified amino acid transport 2 5 2.247319602198352 0.0246196090021832 2.029126213592233 5.587378640776699 1.6181581718562612 0.1578136127091599 1.2124460606928238 1.444653995706506 0.7704353439327314 0.2037484924456972 1.0 0.0040679264544396 0.0158256043387446 0.01180448121602 0.0701952648708137 +Positive regulation of proteasomal ubiquitin dependent protein catabolic process 4 21 2.245763943010075 0.0247191319986257 7.293689320388349 27.25242718446602 -0.0267211937868594 0.6760528955310473 3.8803286544550546 3.673490566712677 0.710215035473384 0.2876322972358245 0.1120923026939533 0.0455724387921432 0.0049422249763305 0.0285848308842562 0.2615198437110484 +Long chain fatty acid transport 5 12 2.240951998546421 0.0250291844810426 3.4514563106796117 12.980582524271844 1.1347693444093316 0.300255043373995 1.9890654524939184 1.4909473272084874 0.7833838873177712 0.258106472565451 1.0 0.134742527043449 0.03403446937649 0.0006954184772239 0.0027845492980534 +Meiotic cell cycle 6 49 2.2399706904745416 0.025092825724321 12.92233009708738 55.842233009708735 0.0993622526463597 0.6833673987108698 5.626634511843725 6.778883751516931 0.7601304899640036 0.3087139543797219 0.0018591566612915 0.0357377282531168 0.0156660237374822 0.074198045372352 0.1984840835719023 +Post translational protein modification 4 11 2.237567916532401 0.0252492457362532 3.1941747572815533 11.516990291262136 0.7357713395172158 0.4534173687037079 1.6073753099185084 1.8147728922350523 0.7925975172795923 0.2972350127351547 0.0504873183962363 0.0096266028600564 0.0032769664110839 0.000812960139445 0.0157766780310383 +Phosphatidic acid metabolic process 0 6 2.233216272520287 0.0255346857448379 2.2233009708737863 6.235436893203883 0.8816881639607732 0.2856229767394486 1.614148841412113 1.5439850574626743 1.1927985254107716 0.2824496640110863 1.0 0.1178616319260966 0.2243071172363204 0.4718643991127431 0.7262550906181415 +Anion transmembrane transport 9 44 2.2065059924566808 0.0273485911229773 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 0.1713201781508957 0.0164824785433421 0.0001035971196841 0.0003763683257436 0.0029667128737802 +Mitochondrial transport 15 85 2.194894192554689 0.0281711885124194 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 0.0025639398806843 1.220543312426503e-06 5.244288534198133e-06 0.0008241549035924 0.0005402851353645 +Positive regulation of neuron differentiation 0 8 2.191080625061794 0.0284459585299479 2.441747572815534 9.097087378640778 0.1489217986910376 0.4752014853635246 2.2799260877069525 1.0636497261494449 1.0912419199569945 0.312731807854903 1.0 0.1952735388158895 0.3559802976275766 0.6691111110298131 0.8940154951559662 +Anaphase promoting complex dependent catabolic process 1 11 2.179369741588993 0.0293042120801259 4.077669902912621 10.12378640776699 0.3430462056909334 0.6217188945699201 2.5955126339094337 1.32625365971685 0.7135808532884087 0.2998091584003682 0.0247368002912169 0.0697581245313758 0.0090253131212995 0.0498779046475234 0.1630814235328921 +Embryonic appendage morphogenesis 2 7 2.177434823866379 0.0294481397761998 2.3228155339805827 10.531553398058252 0.2830839749911006 0.5346739883331655 1.9546220638717424 2.634991297965238 0.8859883497178963 0.2947695295685748 1.0 0.3274019772455256 0.1891654013018039 0.5946863363415549 0.7675249898078017 +Regulation of cell cycle g2 m phase transition 6 32 2.1654441031746963 0.0303536916703204 10.322815533980584 36.16990291262136 -0.2633955266206276 0.6696494432626371 5.569086295781004 5.5363114661991535 0.6372328633761074 0.2798805081266024 0.0104522439455682 0.0748187401998431 0.0131034302652722 0.0077024641720122 0.0384343130412522 +Protein localization to condensed chromosome 2 9 2.157260931349401 0.0309853392727166 3.478155339805826 10.402912621359222 -0.1430889247689732 0.5960748813036063 2.4339844067648415 1.700311582564168 0.7695011403247042 0.2854469479110416 0.0312353468433775 0.0875404472016038 0.0007685743700876 0.0102137155300364 0.0618109910728358 +Icosanoid metabolic process 6 18 2.1536670122401818 0.0312662948875772 4.75 19.37378640776699 -0.8399180664351888 0.2450035647659444 2.0056050100432734 1.995405458715 1.3397112170072694 0.2370184574682143 0.0693787843055262 0.0011246053885867 5.602018844159945e-05 6.880235330436636e-05 0.0009402069411773 +Regulation of autophagy of mitochondrion 2 16 2.142990391275876 0.0321138699346139 3.83495145631068 15.269417475728156 0.5599037905354275 0.4319133125136808 2.249474965186929 2.2839109385500524 1.0076019915675485 0.3108342800197468 0.0520752884473588 0.1430638950507344 0.0035907130786718 0.0415700360883472 0.0674365169251515 +Response to food 2 5 2.142281712800676 0.0321708194983776 1.720873786407767 5.783980582524272 1.3281223897944048 0.1823213242558801 0.9790282548915298 0.8299231919143666 1.0823564620426191 0.211054619984942 1.0 0.0017062060788896 0.0002366501305723 0.003355333516566 0.0225979674873623 +Regulation of chromatin assembly 3 13 2.135705373033559 0.0327034361857938 5.165048543689321 12.407766990291265 -0.3704568736995471 0.547583728777006 2.8688047217655113 2.118741581093374 0.8328837475925533 0.3049024870995975 0.0409067959471478 0.1135912525516411 0.2166826538338764 0.1219531221716571 0.0308662830144804 +Mitotic dna integrity checkpoint signaling 4 23 2.1345699537280303 0.0327961539153471 7.351941747572815 25.385922330097088 -0.1627003517496177 0.6635495256650561 4.014527153781789 3.933191578599673 0.6936501592147415 0.2805248088892694 0.0065863120897145 0.0490886173861251 0.0350615001471499 0.0333870553509734 0.1492508258365027 +Peripheral nervous system development 1 10 2.131535567387188 0.0330450455149042 2.9757281553398056 11.519417475728156 0.6034295307069711 0.4690475043667866 1.8206990026194103 2.156973709389053 0.837829879270116 0.2915098257052096 0.0709369996773478 0.0188245552589776 0.0678620701894922 0.2887846572413305 0.3610395035532395 +Cellular component disassembly involved in execution phase of apoptosis 0 6 2.1266213778837777 0.0334515547906519 2.1966019417475726 7.230582524271845 0.0051538371165724 0.5098237844906576 1.8014794639477176 1.310056935872857 0.9326813328241595 0.290513983378847 1.0 0.0697581245313758 0.1362380906066266 0.307957256786686 0.5262254411875915 +Regulation of response to extracellular stimulus 1 5 2.118558917114294 0.034127760794949 1.0364077669902914 4.466019417475728 1.2416795343104177 0.2058666180593168 0.8221064046230258 0.7766686887277909 1.0462594039989206 0.2178110962907249 1.0 0.0012105019492812 0.0048484802924912 0.027832231049335 0.0968157430558884 +Phosphatidylcholine metabolic process 2 8 2.1169859989868893 0.0342610360754758 3.75 12.592233009708735 0.9144963280277142 0.2812959412325629 1.879404212556404 2.4412987678409657 1.1545250012369797 0.2602001877022786 1.0 0.01497108596825 0.0548237001435711 0.0678108138951911 0.2936288791787133 +Negative regulation of leukocyte apoptotic process 2 5 2.1150558529352743 0.0344251872601693 1.4368932038834952 4.827669902912621 0.5394724631500855 0.429843922437068 1.0942914798916792 1.2373285534927012 1.0763953212919928 0.3167022382829639 1.0 1.0 0.0206800818926893 0.0173886328284286 0.0981468657129251 +Negative regulation of lymphocyte apoptotic process 2 5 2.1150558529352743 0.0344251872601693 1.4368932038834952 4.827669902912621 0.5394724631500855 0.429843922437068 1.0942914798916792 1.2373285534927012 1.0763953212919928 0.3167022382829639 1.0 1.0 0.0115435449528709 0.0074273483269255 0.0465653262864464 +Prostanoid metabolic process 5 12 2.1139177439020087 0.0345222934427669 3.781553398058252 13.131067961165048 -0.261723242286546 0.3706172000065809 1.570619046394198 1.5586606851087283 1.1874779925532215 0.2609303218723489 1.0 0.0063255491406275 9.045443106927394e-05 2.2879176712764704e-05 0.0010205277760807 +Protein import into mitochondrial matrix 1 8 2.104839182484856 0.0353053091590798 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0002712699501443 0.0022827689145391 0.0090253131212995 0.0498779046475234 0.1630814235328921 +Monocarboxylic acid transport 3 8 2.100040806618684 0.035725251635776 2.470873786407767 8.169902912621358 0.4625507315789194 0.4811606769664326 1.4867133927645466 1.500895198986602 0.9205510606636372 0.3061126645026174 1.0 1.0 0.0299460957191466 0.0043549454623746 0.0446088038944012 +Response to estradiol 1 15 2.099420807640374 0.0357798220461276 4.480582524271845 15.609223300970871 -0.1183336658454337 0.5504992412244947 2.9241398453943264 2.3974526081633196 0.8881612224001193 0.295018926126729 1.0 0.0421554091664212 0.1411421437582085 0.4934040207883591 0.8493595544427444 +Purine ribonucleoside metabolic process 3 8 2.0962094841210788 0.0360636119978687 2.063106796116505 7.834951456310679 1.2047777662844132 0.2574288772305114 1.199068432200366 0.6246876870736083 0.9870596763535292 0.2611531847589775 0.0279911849957302 0.0786913117950012 0.0115435449528709 0.00062382482254 0.0078812527225172 +Ribonucleoside metabolic process 3 8 2.0962094841210788 0.0360636119978687 2.1189320388349513 8.12621359223301 1.1914157696469383 0.2635896161542528 1.2648845164842024 0.7462477223524518 0.9827848183963048 0.2624193088278075 0.0393012238682757 0.1093006244161378 0.0224191931510111 0.0024379570615939 0.0269295467729808 +Nucleotide transport 3 14 2.087769364938281 0.0368186442765225 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 1.0 0.1178616319260966 0.0260710687649276 0.0033024410276518 0.0074494564855197 +Protein localization to chromosome centromeric region 2 11 2.067562284256148 0.0386812017084579 3.9927184466019416 11.87864077669903 -0.2062252237633015 0.5917838838617813 2.6690322940622324 2.1429111170145716 0.7708229345345505 0.2870032203248466 0.0393012238682757 0.1093006244161378 0.0015498580582828 0.0195244436529747 0.1083207684216986 +Purine nucleotide transport 3 13 2.066369814792289 0.0387935738585643 4.970873786407767 10.817961165048544 0.961055494000064 0.2880106547862709 2.8308505383502496 1.988649275322177 1.3314072021441097 0.3042395363852717 1.0 0.0919337377678228 0.0158256043387446 0.0011993766429203 0.00223229240551 +Somite development 0 8 2.065654911919715 0.0388610754966216 3.2257281553398056 11.361650485436892 -0.4303675310956571 0.5257701594862517 2.4115454908120273 1.984841876799717 0.8288234464475782 0.2969421491963344 1.0 0.1991580424676108 0.3622612502953293 0.6771624907551994 0.899183688428819 +Ether metabolic process 1 8 2.0619865375972646 0.039209017692412 2.3009708737864076 8.116504854368932 0.6936598083237113 0.3993528168351505 1.8983127483146185 1.066260782267489 0.9725930071190376 0.2989456029254039 0.0296145418928731 0.083126337411673 0.012905013470629 0.0693365470158766 0.0539281835546241 +Mitotic g2 m transition checkpoint 3 12 2.061876178342726 0.0392195260319225 4.002427184466019 15.16747572815534 0.0018113364595217 0.6516717191030562 2.7159174694766737 3.0717330797920166 0.7174053697394586 0.2823436790682436 0.0755969254037073 0.2030241760545403 0.0761270368947914 0.0265672828357611 0.0762091064419948 +Cellular modified amino acid catabolic process 0 6 2.055914903420611 0.039790719325238 1.694174757281553 7.536407766990291 0.7813829585372462 0.4061384510982865 1.3324424789652851 1.4832837844399136 0.782688801302567 0.2725002402105284 1.0 0.083126337411673 0.1611939416425752 0.357118555081159 0.5920308942141137 +Protein localization to golgi apparatus 4 10 2.0523179846455037 0.0401387692955028 3.2888349514563107 9.216019417475728 0.6251969398118403 0.4536668430035578 1.8319101394901296 1.828691420197124 0.8916256553809645 0.3040795237699089 1.0 1.0 1.0 0.4587195489148998 0.0062616815035888 +Neutral lipid biosynthetic process 2 5 2.0504860533257574 0.0403170233899947 2.1067961165048543 6.288834951456311 1.1186547336258812 0.1821371148552785 1.2515048910859687 1.3298556757746482 1.2887117600293918 0.213034599641239 1.0 0.0073558029266518 0.0279813079733609 0.0267619345648551 0.0397044670530444 +Neurotransmitter uptake 1 6 2.0436022899621906 0.04099285287836 1.5995145631067962 5.553398058252427 0.0554856986971852 0.5199714433952961 1.2817993107693917 0.9677133024426112 0.9160506510551608 0.2856840544868526 1.0 0.0786913117950012 0.0115435449528709 0.062605312422627 0.1985866733922443 +Somitogenesis 0 5 2.038715998968184 0.0414783800621636 2.400485436893204 8.390776699029127 -0.3448379182600385 0.482722641237885 1.890779814796092 1.9334089765295457 0.98250510486439 0.3048117633411935 1.0 0.1553991536419083 0.2897038292296705 0.5767416823779237 0.8253222698749051 +Striated muscle cell differentiation 4 38 2.037107134994423 0.041639307056781 9.233009708737864 41.963592233009706 0.2578497820814549 0.6057609991810756 4.193624109843778 4.66250637925984 0.8487717701871332 0.3193425984162805 0.0237533419672435 0.032252333066864 0.0524411855690283 0.2750924467499636 0.5610847252529731 +Lipid homeostasis 6 21 2.034312093324588 0.0419201386418854 7.665048543689321 25.939320388349515 0.8425417577103904 0.3366972259521467 2.992619034719237 3.7336969269092393 1.1648658675422845 0.295769208633365 0.1298272630859544 0.060198214592267 0.0085583503221149 0.0039060955701388 0.0066903761130427 +Endocrine pancreas development 1 5 2.0246278876221804 0.0429055884278624 2.0509708737864076 5.851941747572815 -0.126603332527314 0.527149424927022 1.4497485651188915 1.6220330993069874 0.9029201146380612 0.2859587949302581 0.0473038642381172 0.0084566179175882 0.031964215627013 0.1552222190730896 0.4145551447304083 +Glycerophospholipid catabolic process 1 6 2.0175065840066764 0.0436426746376796 2.216019417475728 7.563106796116505 0.8419758607208171 0.2558936783676348 1.405411068501889 1.391164232085279 1.2384126210044872 0.2497846504551273 1.0 0.0026008925831016 0.0102498345034834 0.0561137872346343 0.1807018090276839 +Respiratory chain complex iii assembly 2 6 2.0134762797853085 0.0440645479263419 1.8470873786407769 5.160194174757281 1.360931378136811 0.1995688008303064 1.0650749835200868 1.2360161344522411 1.0120439004969468 0.2366879233397748 1.0 1.0 0.075113296023457 0.0007187465088185 0.0053031795330487 +Aging 7 67 2.00989003489432 0.0444428286821037 11.805825242718448 65.50242718446601 -0.6341095143184587 0.5390114644062053 6.038803733568983 7.519714796029829 0.7768819097211671 0.3316311207723653 0.0429190032575287 0.0710204091336867 0.0007090880744548 0.1129942712899203 0.6406453135273162 +Homologous chromosome segregation 2 9 2.0085678350146425 0.0445829853167283 2.9441747572815533 9.983009708737864 0.8658101820521615 0.3886675393312038 1.6544409340956687 1.448870557748215 0.8756753907408087 0.3062582021532934 0.0473038642381172 0.1305522111527444 0.031964215627013 0.0322769586697076 0.0498364179528963 +Fatty acid transmembrane transport 3 6 2.0033053107683423 0.0451445278129383 2.3519417475728157 6.720873786407767 1.487456141723218 0.1763040127694548 1.5547987465385102 1.1092073674791965 0.7935702169981724 0.2103298472796338 1.0 0.0561990347849709 0.1105474823156849 0.000142755965642 0.0019884945269669 +Folic acid metabolic process 1 6 2.000424229783155 0.0454544741738107 1.91747572815534 7.140776699029126 1.2977645388348351 0.249592124826322 1.215987926650751 0.8615786924829095 0.8405378716662024 0.2600707347072601 1.0 0.0652597674910206 0.1277572387780678 0.290751966651369 0.1457988469723397 +Regulation of b cell apoptotic process 3 5 1.99923346975062 0.0455830987855254 1.2888349514563109 4.143203883495145 0.4712803824401109 0.4838259091452473 1.0979113453615192 1.1000341685710282 1.0371325316664826 0.3279009485506359 1.0 1.0 0.0067896670197663 0.003355333516566 0.0027630263410089 +Collagen fibril organization 1 9 1.9990275530959467 0.0456053727559184 2.75 8.449029126213592 0.7618465155681635 0.4237593014631459 1.546409872946248 1.4346015410823785 0.9057772992250752 0.3095171034083678 0.0008962090959208 0.0073558029266518 0.0279813079733609 0.0267619345648551 0.1410707299584872 +Peptide catabolic process 4 10 1.9928309230111247 0.0462799644080416 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 1.0 0.0875404472016038 0.0143328298354406 0.0762921742488627 0.0017429018144962 +Unsaturated fatty acid metabolic process 6 21 1.9870248613745016 0.0469196418530788 5.094660194174757 21.366504854368937 -0.9535376445802276 0.2511883814851429 2.002006428286616 2.404313360486384 1.288801901636595 0.2466511013826314 0.0802348466046619 0.0017444833819259 0.0001168596637319 0.0001846255682835 0.0025854516113679 +Myelin assembly 1 7 1.983901576241624 0.0472668131817342 1.3810679611650485 5.334951456310679 0.6604549552139052 0.4058185332666181 1.1354528736988552 1.290157568299922 0.9729130679543696 0.2930816724161147 1.0 0.0875404472016038 0.1693528922958147 0.3727200206787977 0.2348875720984273 +Cell cycle g2 m phase transition 9 43 1.9833672733756995 0.047326419927965 12.218446601941748 48.45145631067961 -0.092405630335816 0.7056775458279647 5.362205885257159 7.0180123880739345 0.626748060221498 0.2770821849978692 0.0013474758590583 0.026864373693868 0.0100145073258677 0.0168036951743281 0.0637100212839147 +Nucleobase containing small molecule biosynthetic process 2 7 1.974084398638957 0.0483721470189171 1.7135922330097086 6.725728155339806 0.7645590390237343 0.3868941709719335 1.5487262880443011 0.5167281344531495 1.0510813905138674 0.3156372982117756 0.0214721625357582 0.0607401038440192 0.0067896670197663 0.003355333516566 0.0225979674873623 +Glycosyl compound biosynthetic process 2 7 1.974084398638957 0.0483721470189171 1.7621359223300972 6.927184466019417 0.7674599123201137 0.3848892158216302 1.5816678247150102 0.68587612099484 1.0539983320068638 0.3161304697180149 0.0279911849957302 0.0786913117950012 0.0115435449528709 0.0074273483269255 0.0465653262864464 +Peroxisomal transport 2 5 1.9737035173232869 0.0484154649995254 2.4199029126213594 6.206310679611651 0.5152791591885746 0.4397608531291631 1.438341814396029 1.9279897928521967 0.9960993615772044 0.3114134157114668 1.0 1.0 1.0 0.0834574734746242 0.0701952648708137 +Regulation of mitochondrial membrane permeability 1 14 1.9724210804189692 0.0485615573276729 3.966019417475728 14.96359223300971 0.2402793183028587 0.524743519159013 2.950861430851842 1.4816465220322803 0.9084604001489732 0.298358218544212 0.0724927592309665 0.0196403757049561 0.0705821305211966 0.2978006616879862 0.3744563663843071 +Retinoic acid receptor signaling pathway 0 7 1.969208069300863 0.048929202645501 2.8398058252427183 6.764563106796117 -0.568222238943345 0.4629210051092607 1.720399581369897 0.7761033820373193 0.8965863066734527 0.2959772743856227 1.0 0.1049896535105009 0.2012104780589677 0.4314443861210575 0.6820616738325311 +Meiotic chromosome segregation 2 19 1.96091319661752 0.0498891496305764 5.007281553398058 21.320388349514563 0.2019802860830169 0.6490546122321188 2.8297046722897017 2.442398917159905 0.7194362300409552 0.2944438752029195 0.0833146174643958 0.2220822570468345 0.0905584027773802 0.1312000588255236 0.2447590412697401 +Regulation of polysaccharide metabolic process 1 5 1.960398034855392 0.0499492853747425 2.7111650485436893 6.490291262135922 -0.3346292065965149 0.508123876720181 1.610515084324468 1.2394811444307563 0.949051662303766 0.3169592400007221 0.0457083727275927 0.0078974776787256 0.0299460957191466 0.1467432355955838 0.3973105708638685 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b3da24f2263c18b010a69d625576cf0540684626 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 6391, + "title": "Average number of proteins per term", + "value": 18.58707557502738 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b53fbc6869eaac1216de1a53f3a30c4202d6f5ef --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c974cface42e8a21a582efe86614da67fc11e135 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1593 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Positive regulation of dna replication 0.7942706278036209 2.944466985862886 0.0032351145902351 0.9999999989857676 0.3665407736562412 16 P06493,P24941 2 +Vascular transport 0.8056861626636865 2.9113707556083175 0.0035984674510081 0.9999999999013344 0.3665407736562412 14 P08183,Q99808,P30825,P41440,P53985 5 +Cardiac muscle cell differentiation 0.8233668782590943 2.8498012799025356 0.0043746551971872 0.999999999999322 0.3665407736562412 13 P06493,P49840 2 +Vascular process in circulatory system 0.6605492925497369 2.7623703119080107 0.0057383353599993 1.0 0.3665407736562412 31 Q9HB40,P53985,P08183,O15439,Q99808,P30825,P41440,P42892 8 +Protein transmembrane transport 0.6697221022949847 2.7569085206144934 0.0058350673444245 1.0 0.3665407736562412 25 Q9NS69,Q99595,O75381,O95831,Q15629,O60830 6 +Lipid localization 0.4952439325267952 2.669195254837075 0.0076033235512082 1.0 0.3665407736562412 72 P35610,Q86Y82,O15118,Q9H2V7,P08183,O43772,O15439,Q99720,P23786,P33121,P28288,P30536,P14174,Q9H4L5,O15260,Q8WTV0,Q9UHB6 17 +Anion transport 0.4947882193855055 2.6513908141975446 0.0080161026490861 1.0 0.3665407736562412 73 Q14728,Q9Y619,Q9BQT8,Q8TDW0,Q9H0H5,P08183,O15439,Q99808,Q6N075,P30825,P14174,P41440,P30536,P53985,Q9UHG3 15 +Protein transmembrane import into intracellular organelle 0.7817091462982261 2.64752401961343 0.0081083599355242 1.0 0.3665407736562412 13 Q99595,O60830,O95831 3 +Secondary alcohol metabolic process 0.6332184166448371 2.6401185611961986 0.0082877028071504 1.0 0.3665407736562412 35 P34913,P35610,P37268,Q15392,Q16850,Q14739,Q9UBM7,Q15126,P48735,Q8WTV0,Q9UHB6 11 +Organic acid transmembrane transport 0.6410784254650888 2.63189405094307 0.0084910337313359 1.0 0.3665407736562412 31 Q9Y619,Q9BQT8,Q8TDW0,P08183,O43772,P23786,P33121,P30825,P41440,P53985 10 +Protein hydroxylation 0.7390351163569477 2.57313254386625 0.0100782603080658 1.0 0.3665407736562412 14 Q92791,O75718,P07237,Q32P28,O15460,P13674 6 +Intracellular protein transmembrane transport 0.6762786138534372 2.5725024554970046 0.0100966239710671 1.0 0.3665407736562412 21 Q99595,O60830,O95831,Q15629 4 +Mitochondrial transmembrane transport 0.5587935269905304 2.556477265015283 0.0105737980471327 1.0 0.3665407736562412 52 Q9Y4W6,Q99595,P00846,Q9Y619,P06576,Q9BQT8,O43772,O95831,Q8WWC4,P23786,O60830 11 +Regulation of blood pressure 0.6982187973648627 2.528012406090354 0.0114710298499649 1.0 0.3665407736562412 18 P49840,P42785,P42892 3 +Organic acid transport 0.5818132242216796 2.527021298852534 0.0115034526178441 1.0 0.3665407736562412 46 Q9Y619,Q9BQT8,Q8TDW0,P08183,O43772,O15439,P23786,P33121,P30825,P14174,P41440,P53985 12 +Cardiocyte differentiation 0.6965988088481381 2.518895440829287 0.0117723609489601 1.0 0.3665407736562412 18 P06493,P49840 2 +Negative regulation of mrna splicing via spliceosome 0.71412095459644 2.480428052603946 0.0131224743481215 1.0 0.3665407736562412 15 P61978,Q13242,Q16629,O75494,P38159,P98175 6 +Chromosome condensation 0.6384421329077419 2.475153578067778 0.0133178893050649 1.0 0.3665407736562412 23 P10412,P07305,O95831,P16403,O43823,P53350,P06493,P84243 8 +Pancreas development 0.8496076233156432 2.47439036910402 0.0133463775765614 1.0 0.3665407736562412 9 P49840,O94788 2 +Positive regulation of dna dependent dna replication 0.9247299526757068 2.47134969652439 0.0134604121332728 1.0 0.3665407736562412 6 P24941 1 +Meiosis i cell cycle process 0.7038671357149864 2.4660619723526964 0.0136607696897885 1.0 0.3665407736562412 16 P53350,P46100,Q92791 3 +Endocrine system development 0.770510508915766 2.4637187945467622 0.0137503943789845 1.0 0.3665407736562412 12 P49840,P49841,O94788 3 +Cardiac cell development 0.7944318550519323 2.459179249382027 0.013925507023391 1.0 0.3665407736562412 11 P06493,P49840 2 +Carbohydrate derivative transport 0.6764727484103996 2.4561502679467258 0.0140434420939028 1.0 0.3665407736562412 19 Q99808,Q8WTV0,Q8TDW0,P41440 4 +Negative regulation of mrna processing 0.6550355957744757 2.4445774759643757 0.0145021928849304 1.0 0.3767622549902062 21 P61978,Q13242,Q16629,O75494,P38159,P18615,P22626,P98175 8 +Fatty acid transport 0.702275091864342 2.417047731255048 0.0156469651702453 1.0 0.3880827768640733 15 O43772,P23786,P33121,P28288,P14174 5 +Determination of adult lifespan 0.8639525456778676 2.396588326758784 0.0165485044888835 1.0 0.3990999705224711 7 O75844 1 +Organic cation transport 0.9051393721964184 2.3938329589413585 0.0166733402991181 1.0 0.4005989392919704 6 Q99808,O43772 2 +Negative regulation of rna splicing 0.6781795152869046 2.3676992083397517 0.0178990812405923 1.0 0.4111911272079267 17 P61978,Q13242,Q16629,O75494,P38159,Q9UKA9,P98175 7 +Negative regulation of cell development 0.660592859221977 2.3637041668735224 0.0180932540833436 1.0 0.4111911272079267 19 Q96G23,P49840,P49841 3 +Cellular response to reactive nitrogen species 0.8549104033730563 2.358977730996098 0.0183253554151252 1.0 0.4111911272079267 7 O95831 1 +Response to nitric oxide 0.8549104033730563 2.358977730996098 0.0183253554151252 1.0 0.4111911272079267 7 O95831 1 +Multicellular organism aging 0.7729240185928992 2.358749258237634 0.0183366407845813 1.0 0.4111911272079267 11 O75844 1 +Muscle cell development 0.6071054445092366 2.3556537148515035 0.0184901452690251 1.0 0.4131836308193696 26 P06493,P49840,O75844 3 +External encapsulating structure organization 0.6045009452037715 2.352338040492467 0.0186558121017892 1.0 0.4154330841203311 28 Q92791,O75718,P13674,P41440,P39210 5 +Alcohol metabolic process 0.4673342990521724 2.3361122274548736 0.0194853931989311 1.0 0.4231732912960053 75 Q9NX62,P34913,P35610,O94788,Q9BY49,Q10713,P37268,Q15392,P30837,Q16850,Q9UBM7,Q14739,Q15126,Q9BW91,P48735,Q8WTV0,Q9UHB6 17 +Positive regulation of mitochondrion organization 0.6261264922445557 2.3292771035238884 0.0198443905367018 1.0 0.4242720351787434 22 P21796,P49840,P49841,P27544,Q96A26,Q9GZY8 6 +Appendage development 0.7666401524222444 2.329183014981975 0.0198493723233366 1.0 0.4242720351787434 11 P42892,P46100,O94788 3 +Positive regulation of ubiquitin dependent protein catabolic process 0.6154133298932274 2.3279012521740885 0.0199173477535341 1.0 0.4243058983094559 23 P53350,Q96HY6,P49840,P49841 4 +Vitamin transmembrane transport 0.884937180261789 2.3131516894347297 0.0207143006364125 1.0 0.4256755478048638 6 P41440 1 +Negative regulation of cell cycle process 0.4579816796617168 2.3024979919129684 0.0213071045373076 1.0 0.4279853991581773 70 Q96GD4,Q9Y619,Q96RU2,P49454,Q96DY7,Q96K76,Q6IQ49,Q8N6R0,Q96PK6,P46100,P53350,P06493,P24941,Q68E01 14 +Organophosphate ester transport 0.595107385250098 2.2966278840494314 0.021640006566153 1.0 0.4279853991581773 29 Q8TDW0,P08183,Q99808,P41440,Q8WTV0 5 +Response to toxic substance 0.5444539795650788 2.2891397520195595 0.0220712337856217 1.0 0.4279853991581773 48 P07099,Q15165,P08183,O95831,P27544,P06493 6 +Regulation of dna dependent dna replication 0.638005770552595 2.2831264967675966 0.0224229181931494 1.0 0.4279853991581773 20 O75844,P24941 2 +Vitamin transport 0.8350249760217516 2.275671767073153 0.0228656623722738 1.0 0.4279853991581773 7 P41440 1 +Appendage morphogenesis 0.8030755145588461 2.2722451217361868 0.0230717093541616 1.0 0.4279853991581773 9 P42892,P46100,O94788 3 +Peptidyl proline hydroxylation 0.8342099945853493 2.2722401712833133 0.0230720081915776 1.0 0.4279853991581773 7 O75718,P07237,O15460,Q32P28,P13674 5 +Organic hydroxy compound transport 0.5876893044298798 2.264626383474558 0.0235356164672062 1.0 0.4279853991581773 31 Q14728,P35610,Q86Y82,P53985,O15439,P28288,P30536,Q9H4L5,Q8WTV0,Q9UHB6 10 +Negative regulation of cell differentiation 0.4506247006084377 2.264001740718494 0.0235740077154986 1.0 0.4279853991581773 67 Q14004,Q96G23,P49840,P49841,Q8N4Q0 5 +Regulation of neuron differentiation 0.6432060095847834 2.261404497321327 0.0237342205316868 1.0 0.4279853991581773 19 Q8WUJ1 1 +Regulation of systemic arterial blood pressure 0.8715767907889118 2.2593790567472793 0.0238598160260203 1.0 0.4279853991581773 6 P42785,P49840 2 +Purine containing compound transmembrane transport 0.7757874704187447 2.2563526357727945 0.0240485554066955 1.0 0.4279853991581773 10 Q99808,Q8TDW0,P41440 3 +Modified amino acid transport 0.9090521993128786 2.247319602198352 0.0246196090021832 1.0 0.4305474378568038 5 O43772,P41440 2 +Positive regulation of proteasomal ubiquitin dependent protein catabolic process 0.6226037732582812 2.245763943010075 0.0247191319986257 1.0 0.4305474378568038 21 P53350,Q96HY6,P49840,P49841 4 +Long chain fatty acid transport 0.7249067999208129 2.240951998546421 0.0250291844810426 1.0 0.4346023013662214 12 O43772,P23786,P33121,P28288,P14174 5 +Meiotic cell cycle 0.5345943890079383 2.2399706904745416 0.025092825724321 1.0 0.4346023013662214 49 Q9BTX1,Q92791,Q9UQ84,P53350,P24941,P46100 6 +Post translational protein modification 0.7473038537750959 2.237567916532401 0.0252492457362532 1.0 0.4361295391902546 11 Q9HA64,Q32P28,Q8TCJ2,O75718 4 +Anion transmembrane transport 0.5486504781707702 2.2065059924566808 0.0273485911229773 1.0 0.4493183698379137 44 Q14728,Q9BQT8,Q8TDW0,P08183,O15439,P30825,P41440,P53985,Q9UHG3 9 +Mitochondrial transport 0.4661824407969184 2.194894192554689 0.0281711885124194 1.0 0.4592909841399805 85 Q5JRX3,P55786,Q99595,P00846,Q9NS69,P06576,Q10713,P49840,O43772,O95831,P49841,Q8WWC4,P23786,P30536,O60830 15 +Anaphase promoting complex dependent catabolic process 0.7351243048550021 2.179369741588993 0.0293042120801259 1.0 0.4717461445946716 11 P24941 1 +Embryonic appendage morphogenesis 0.8118213729196306 2.177434823866379 0.0294481397761998 1.0 0.4728720133409381 7 P42892,O94788 2 +Regulation of cell cycle g2 m phase transition 0.5721239246064589 2.1654441031746963 0.0303536916703204 1.0 0.4861915876316237 32 Q96GD4,Q9Y619,P53350,P06493,P24941,Q68E01 6 +Protein localization to condensed chromosome 0.777093241217397 2.157260931349401 0.0309853392727166 1.0 0.4917011151030655 9 Q96GD4,P06493 2 +Icosanoid metabolic process 0.6330272650698062 2.1536670122401818 0.0312662948875772 1.0 0.4931788686423853 18 P07099,Q15067,Q8N8N7,P14174,Q8N4Q0,Q9H7Z7 6 +Regulation of autophagy of mitochondrion 0.6455538146175529 2.142990391275876 0.0321138699346139 1.0 0.5025432498668357 16 P49840,P27544 2 +Response to food 0.8821620018944759 2.142281712800676 0.0321708194983776 1.0 0.5025432498668357 5 Q9UMX5,P80303 2 +Regulation of chromatin assembly 0.6806227336265159 2.135705373033559 0.0327034361857938 1.0 0.5048494218922912 13 P12270,P24941,Q8NEY8 3 +Mitotic dna integrity checkpoint signaling 0.5857143288027852 2.1345699537280303 0.0327961539153471 1.0 0.5050607702963467 23 P53350,P06493,P24941,Q9Y619 4 +Peripheral nervous system development 0.7486716514620464 2.131535567387188 0.0330450455149042 1.0 0.5052099931280241 10 Q9NR77 1 +Regulation of response to extracellular stimulus 0.8761306416053708 2.118558917114294 0.034127760794949 1.0 0.5087273300378606 5 Q9UMX5 1 +Phosphatidylcholine metabolic process 0.7829413258369243 2.1169859989868893 0.0342610360754758 1.0 0.5087273300378606 8 Q8NCC3,Q8WTV0 2 +Negative regulation of leukocyte apoptotic process 0.8752412870807834 2.1150558529352743 0.0344251872601693 1.0 0.5087273300378606 5 Q96GD4,P14174 2 +Negative regulation of lymphocyte apoptotic process 0.8752412870807834 2.1150558529352743 0.0344251872601693 1.0 0.5087273300378606 5 Q96GD4,P14174 2 +Prostanoid metabolic process 0.6994087204883594 2.1139177439020087 0.0345222934427669 1.0 0.5087273300378606 12 Q15067,Q8N8N7,P14174,Q8N4Q0,Q9H7Z7 5 +Protein import into mitochondrial matrix 0.7801688991334744 2.104839182484856 0.0353053091590798 1.0 0.5087273300378606 8 Q99595 1 +Monocarboxylic acid transport 0.7790747265153786 2.1000408066186833 0.035725251635776 1.0 0.5087273300378606 8 P53985,O15439,P14174 3 +Response to estradiol 0.6441514891949573 2.099420807640374 0.0357798220461276 1.0 0.5087273300378606 15 O94788 1 +Purine ribonucleoside metabolic process 0.7782014856213936 2.0962094841210788 0.0360636119978687 1.0 0.5087273300378606 8 P55263,Q13126,O60725 3 +Ribonucleoside metabolic process 0.7782014856213936 2.0962094841210788 0.0360636119978687 1.0 0.5087273300378606 8 P55263,Q13126,O60725 3 +Nucleotide transport 0.6478472369020295 2.087769364938281 0.0368186442765225 1.0 0.5148970581427919 14 Q99808,Q8TDW0,P41440 3 +Protein localization to chromosome centromeric region 0.711943613449008 2.067562284256148 0.0386812017084579 1.0 0.5184992348620229 11 Q96GD4,P06493 2 +Purine nucleotide transport 0.667366780683588 2.0663698147922895 0.0387935738585643 1.0 0.5184992348620229 13 Q99808,Q8TDW0,P41440 3 +Ether metabolic process 0.7704175595696343 2.0619865375972646 0.039209017692412 1.0 0.5190593706501467 8 P07099 1 +Mitotic g2 m transition checkpoint 0.68906368080555 2.061876178342726 0.0392195260319225 1.0 0.5190593706501467 12 P53350,P06493,Q68E01 3 +Protein localization to golgi apparatus 0.7316554046212628 2.0523179846455033 0.0401387692955028 1.0 0.5267492290914966 10 O14976,Q96CV9,Q8TD16,P49755 4 +Neutral lipid biosynthetic process 0.8589061834112005 2.0504860533257574 0.0403170233899947 1.0 0.5269245326900952 5 Q8NCC3,Q8WTV0 2 +Neurotransmitter uptake 0.81876280235614 2.0436022899621906 0.04099285287836 1.0 0.5305730989386876 6 P41440 1 +Striated muscle cell differentiation 0.5433338587858386 2.037107134994423 0.041639307056781 1.0 0.5305730989386876 38 P06493,P49840,O75844,P41440 4 +Lipid homeostasis 0.5888393979360792 2.034312093324588 0.0419201386418854 1.0 0.5305730989386876 21 P34913,P35610,O15260,Q8WTV0,O15254,Q9UHB6 6 +Endocrine pancreas development 0.8523946891736911 2.0246278876221804 0.0429055884278624 1.0 0.5305730989386876 5 P49840 1 +Glycerophospholipid catabolic process 0.8124581950643448 2.0175065840066764 0.0436426746376796 1.0 0.5305730989386876 6 Q8WTV0 1 +Respiratory chain complex iii assembly 0.8114860111199264 2.0134762797853085 0.0440645479263419 1.0 0.5305730989386876 6 Q69YU5,Q5U5X0 2 +Aging 0.4273117122785399 2.00989003489432 0.0444428286821037 1.0 0.5305730989386876 67 Q96GD4,P00846,P14174,P06493,P24941,P46100,O75844 7 +Homologous chromosome segregation 0.7439851244608408 2.0085678350146425 0.0445829853167283 1.0 0.5305730989386876 9 P53350,Q92791 2 +Fatty acid transmembrane transport 0.8090343783743086 2.0033053107683423 0.0451445278129383 1.0 0.5305730989386876 6 P23786,P33121,O43772 3 +Folic acid metabolic process 0.8083403814559292 2.000424229783155 0.0454544741738107 1.0 0.5305730989386876 6 P41440 1 +Regulation of b cell apoptotic process 0.8460163851758419 1.9992334697506196 0.0455830987855254 1.0 0.5305730989386876 5 Q96GD4,P00813,P14174 3 +Collagen fibril organization 0.7418789687865209 1.9990275530959467 0.0456053727559184 1.0 0.5305730989386876 9 Q92791 1 +Peptide catabolic process 0.7189718740388038 1.9928309230111247 0.0462799644080416 1.0 0.5305730989386876 10 P09960,P42892,O14773,P55786 4 +Unsaturated fatty acid metabolic process 0.5813844553283373 1.9870248613745016 0.0469196418530788 1.0 0.5316727501472108 21 P07099,Q15067,Q8N8N7,P14174,Q8N4Q0,Q9H7Z7 6 +Myelin assembly 0.766847515424484 1.983901576241624 0.0472668131817342 1.0 0.5316733825471769 7 Q9NR77 1 +Cell cycle g2 m phase transition 0.5238018268827414 1.9833672733756993 0.047326419927965 1.0 0.5316733825471769 43 Q96GD4,Q9Y619,P49454,P08183,O43823,P53350,P06493,P24941,Q68E01 9 +Nucleobase containing small molecule biosynthetic process 0.7645910132942699 1.9740843986389571 0.0483721470189171 1.0 0.5316733825471769 7 P55263,Q13126 2 +Glycosyl compound biosynthetic process 0.7645910132942699 1.9740843986389571 0.0483721470189171 1.0 0.5316733825471769 7 P55263,Q13126 2 +Peroxisomal transport 0.8396201558412874 1.9737035173232869 0.0484154649995254 1.0 0.5316733825471769 5 P28288,O75381 2 +Regulation of mitochondrial membrane permeability 0.6268691266669297 1.9724210804189697 0.0485615573276729 1.0 0.5316733825471769 14 P49840 1 +Meiotic chromosome segregation 0.5931900949346738 1.9609131966175195 0.0498891496305764 1.0 0.5316733825471769 19 P53350,Q92791 2 +Regulation of polysaccharide metabolic process 0.8362929345666462 1.960398034855392 0.0499492853747425 1.0 0.5316733825471769 5 P49840 1 +Regulation of attachment of spindle microtubules to kinetochore 0.7612840293310058 1.9596788571616377 0.0500333378930144 1.0 0.5316733825471769 7 Q96GD4,Q9H0H5,P25054 3 +Nucleotide transmembrane transport 0.7331776347322929 1.9595115861676955 0.0500529043583717 1.0 0.5316733825471769 9 Q8TDW0,P41440 2 +Detection of biotic stimulus 0.835950450163687 1.9590274745387084 0.0501095692966711 1.0 0.5316733825471769 5 Q8WTV0,P30536 2 +Negative regulation of response to wounding 0.7607869587414453 1.9575117127511308 0.0502873360719087 1.0 0.5316733825471769 7 Q96G23 1 +Regulation of striated muscle cell differentiation 0.7464502831640201 1.9558160569047345 0.0504868266648672 1.0 0.5324444046454895 8 P49840,Q8NEZ5 2 +Negative regulation of b cell apoptotic process 0.914243051764116 1.9545412603095864 0.0506372402834647 1.0 0.5331509104639589 4 Q96GD4,P14174 2 +Regulation of transcription regulatory region dna binding 0.7312463395895876 1.9507188453056252 0.0510905003232271 1.0 0.534829251094292 9 Q96HY6,P09874,O75844 3 +Purine containing compound salvage 0.7591509264732419 1.9503754683306107 0.0511313835735585 1.0 0.534829251094292 7 P55263,Q13126 2 +Positive regulation of leukocyte proliferation 0.6106307288401069 1.9441010536795051 0.051883266238526 1.0 0.5374164579099185 16 P07948,P04439,P00813,P30825,P14174,P98172 6 +Endochondral bone morphogenesis 0.8316699712005444 1.9418825302661349 0.0521513227411856 1.0 0.5375907023546735 5 O75844,P08133 2 +Response to dopamine 0.6157592370416292 1.9403264505034377 0.0523400288019 1.0 0.5375907023546735 15 P49840 1 +Mesenchymal cell development 0.664805654947938 1.9387321733148355 0.0525339588860598 1.0 0.5375907023546735 12 Q13428,Q14978,P98172,O94788 4 +Neural crest cell differentiation 0.664805654947938 1.9387321733148355 0.0525339588860598 1.0 0.5375907023546735 12 Q13428,Q14978,P98172,O94788 4 +Positive regulation of chromatin organization 0.7284157690682506 1.937817555139418 0.0526454852155957 1.0 0.5375907023546735 9 P24941,Q8NEY8 2 +Hormone metabolic process 0.5420145462036468 1.9316066932885352 0.0534080690919189 1.0 0.5375907023546735 30 O94788,Q8TAD4,P30536,O75844,P42892 5 +Chromosome organization involved in meiotic cell cycle 0.6075054924680745 1.9261124836472547 0.0540903301974315 1.0 0.5384599693018463 16 P46100,Q92791 2 +Bone morphogenesis 0.7526157873163986 1.9218176345806703 0.0546287085882262 1.0 0.542973680540208 7 O75844,P08133 2 +Viral protein processing 0.7236482791057728 1.916049711241856 0.0553587684499632 1.0 0.5476747510274227 9 P49840 1 +Mitotic spindle midzone assembly 0.824814157127935 1.914364000491111 0.0555736620188769 1.0 0.548103817843584 5 Q96GD4 1 +Negative regulation of cell cycle 0.4326832962794619 1.907820713681322 0.0564143926129709 1.0 0.5495705471399158 79 Q96GD4,Q9Y619,Q96RU2,P49454,Q96DY7,Q6IQ49,Q96K76,Q8N6R0,Q96PK6,Q68E01,P53350,P06493,P24941,P46100 14 +Response to testosterone 0.7007394788525982 1.906673325630735 0.0565629032481163 1.0 0.5495705471399158 10 Q13126 1 +Negative regulation of stem cell differentiation 0.7836078399423131 1.8972004938180935 0.0578014817115075 1.0 0.5530078886500671 6 Q14004 1 +Copi coated vesicle budding 0.8974888973702996 1.890947681768241 0.0586313285128681 1.0 0.5574692929566644 4 Q8N6H7 1 +Golgi vesicle budding 0.8974888973702996 1.890947681768241 0.0586313285128681 1.0 0.5574692929566644 4 Q8N6H7 1 +Regulation of postsynaptic membrane potential 0.6755689772382472 1.8894220429353423 0.0588352995477892 1.0 0.5574692929566644 11 Q99808,P49840,P49841,Q9UQB8 4 +Chemical synaptic transmission postsynaptic 0.6755689772382472 1.8894220429353423 0.0588352995477892 1.0 0.5574692929566644 11 Q99808,P49840,P49841,Q9UQB8 4 +Response to oxygen levels 0.4519437713331178 1.889100322723283 0.0588783872235563 1.0 0.5574692929566644 59 P55786,P00846,P03915,P07237,P00813,O95831,Q99808,P30519,Q8N511 9 +Inorganic anion transport 0.5359257690206937 1.8813727225859511 0.0599212347550746 1.0 0.56101625339685 29 Q8TDW0,Q9H0H5,P08183,Q6N075,P30536,Q9UHG3 6 +Regulation of lymphocyte apoptotic process 0.7292966333777751 1.879106067613327 0.0602300118194496 1.0 0.5627237189246724 8 Q96GD4,P00813,P14174 3 +Regulation of membrane permeability 0.5796198203906592 1.877848532863968 0.0604018887783328 1.0 0.5627237189246724 19 P49840 1 +Protein trimerization 0.8937886531646453 1.8768564259300256 0.0605377743956512 1.0 0.5631687280387292 4 Q99720 1 +Purine nucleoside biosynthetic process 0.777046302461296 1.8696395354173785 0.0615338912317313 1.0 0.5658461854129426 6 P55263,Q13126 2 +Positive regulation of nucleocytoplasmic transport 0.531060950803773 1.8684484726621289 0.0616995859932048 1.0 0.566554675405994 32 Q9Y3B8,O00459,P12270,Q9H7Z3,P49841,Q9NPF5,P06493,P50402 8 +Organic anion transport 0.4906762353037852 1.8648308040871953 0.0622051240340808 1.0 0.5684798149364584 49 Q14728,Q9Y619,Q9BQT8,Q8TDW0,O15439,Q99808,P41440,P30825,P14174,P53985 10 +Regulation of keratinocyte proliferation 0.8123917085939945 1.8643214375750288 0.0622765780736345 1.0 0.5684798149364584 5 Q9Y3B8 1 +Keratinocyte proliferation 0.8123917085939945 1.8643214375750288 0.0622765780736345 1.0 0.5684798149364584 5 Q9Y3B8 1 +Histone phosphorylation 0.5621056591676288 1.8637701448673103 0.0623539900282361 1.0 0.5684798149364584 21 Q96GD4,Q9NY27,P17252,O43823,P06493,P24941,O75844 7 +Negative regulation of gliogenesis 0.8119450816218631 1.8625179888609324 0.062530112224572 1.0 0.5692734290986324 5 Q96G23 1 +Cholesterol efflux 0.7245218017893901 1.8576487293829036 0.0632189137534102 1.0 0.5720614554022952 8 Q8WTV0,P35610,Q86Y82 3 +Sterol homeostasis 0.689773959403926 1.8544971604394351 0.063668066020833 1.0 0.5733266877221841 10 P34913,Q8WTV0,P35610,Q9UHB6 4 +Sterol metabolic process 0.5289126156439025 1.852698798652453 0.0639255423143456 1.0 0.5733266877221841 32 P34913,P35610,P37268,Q15392,Q16850,Q14739,Q9UBM7,Q15126,Q8WTV0,Q9UHB6 10 +Porphyrin containing compound metabolic process 0.5823948226671806 1.8525699106229252 0.0639440285356889 1.0 0.5733266877221841 18 P50336,P36551,P22830,P30519,P30536,Q9UII2 6 +Regulation of mitochondrion organization 0.5074060185687845 1.8509554354420108 0.0641759645724433 1.0 0.5733266877221841 43 P21796,P49840,P49841,Q99536,P27544,Q96A26,P30536,Q9GZY8,Q9UII2 9 +Mitochondrial respiratory chain complex assembly 0.5122525129544562 1.849266360815286 0.0644193606018761 1.0 0.5733266877221841 41 Q5U5X0,P03915,Q8N183,O95831,Q69YU5,Q6DKK2,O43676 7 +Positive regulation of membrane permeability 0.6467724626737781 1.846206553984716 0.0648622196956902 1.0 0.5733266877221841 12 P49840 1 +Cellular response to retinoic acid 0.7083995142689137 1.8461065674261132 0.0648767334589277 1.0 0.5733266877221841 9 O94788 1 +Negative regulation of muscle cell differentiation 0.7216365357709704 1.844661090681628 0.0650868542564457 1.0 0.5733266877221841 8 P49840 1 +Phospholipid transport 0.5984763566379997 1.8422776073517455 0.0654345535041383 1.0 0.5733266877221841 15 P08183 1 +Regulation of rna splicing 0.4359237780847843 1.8403877982321888 0.0657113235632391 1.0 0.5733266877221841 87 Q07955,Q92841,P17844,P31943,P31942,P98179,P35637,P98175,Q08170,P51116,Q13243,Q13595,P31483,Q12849,Q9UKA9,Q96T37,Q14320,Q16629,P19338,P84103,Q96PU8,O60828,Q9NTZ6,Q8IY67,Q96E39,P22626,Q5BKZ1,Q14011,P61978,Q13242,Q9BWF3,Q14684,O75525,O75494,P38159,P52597,Q92879,P09651,P55795,P62995,Q8WVV9,Q9Y2W1 42 +Nucleoside salvage 0.8059187216810896 1.838155534315851 0.0660394898886509 1.0 0.5733266877221841 5 Q13126 1 +Purine ribonucleoside salvage 0.8059187216810896 1.838155534315851 0.0660394898886509 1.0 0.5733266877221841 5 Q13126 1 +Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.7693058065232616 1.8370342848388204 0.0662048342260948 1.0 0.5733266877221841 6 P49840 1 +Glandular epithelial cell differentiation 0.805118641667764 1.834917138008696 0.0665179679430512 1.0 0.5741780022440128 5 P49840 1 +Membrane lipid biosynthetic process 0.540693706038879 1.8343626527265935 0.0666001796053092 1.0 0.5741780022440128 23 Q06136,Q96G23,Q8NBX0 3 +Regulation of proteasomal ubiquitin dependent protein catabolic process 0.502485716931151 1.832949065749483 0.0668101460324908 1.0 0.5746751592108327 44 P49840,P49841,Q96HY6,P53350,P24941 5 +Dopamine receptor signaling pathway 0.6846139122890942 1.8298537068272207 0.067271817355154 1.0 0.5763620595749178 10 P49840 1 +Tetrapyrrole biosynthetic process 0.6227708017255483 1.8294864947483649 0.0673267606622962 1.0 0.5763620595749178 13 P50336,P30536,P22830,P36551 4 +Sterol transport 0.5396597352087507 1.827372095943965 0.0676438419083149 1.0 0.5771853052550613 23 P35610,Q86Y82,P30536,Q9H4L5,Q8WTV0,Q9UHB6 6 +Glial cell proliferation 0.7665971771854762 1.8256014892462695 0.0679103113268055 1.0 0.5786863995861526 6 P30536,Q96G23 2 +Cell aging 0.528269371911349 1.8214638519160191 0.068536376713008 1.0 0.5824680632617479 28 P06493,P24941,P14174 3 +Cellular hormone metabolic process 0.5695505181676116 1.815813673108288 0.0693989591413717 1.0 0.5847498828357033 19 P42892,P30536,O94788 3 +Regulation of receptor recycling 0.7629245538621395 1.810080780402187 0.0702832609996555 1.0 0.5850443109696846 6 P42892,Q96CV9 2 +Negative regulation of mitotic cell cycle 0.4773322355963245 1.8100757723153127 0.0702840375226256 1.0 0.5850443109696846 51 Q96GD4,Q9Y619,P49454,Q96DY7,Q96K76,Q6IQ49,P53350,P06493,P24941,Q68E01 10 +Positive regulation of neuron death 0.5859393000299327 1.8011675437977015 0.0716764763155781 1.0 0.5883210212894835 16 P49841,O95831 2 +Peptidyl threonine modification 0.5252997582345666 1.8002645123644732 0.0718188815816658 1.0 0.5883210212894835 28 P06493,P49840,P49841 3 +Microtubule organizing center organization 0.5123674313437752 1.799111419346047 0.0720010576406082 1.0 0.5883210212894835 38 Q15004,Q7Z4H7,Q96PK6,Q9H6D7,P53350,P06493,P24941,P53985 8 +Regulation of mitochondrial membrane permeability involved in apoptotic process 0.6776754297311021 1.7966268524108957 0.0723948785095029 1.0 0.5883210212894835 10 P49840 1 +Protoporphyrinogen ix metabolic process 0.7945303029802826 1.791974070342847 0.073137119659542 1.0 0.5913729287378096 5 P50336,P22830 2 +Positive regulation of blood circulation 0.8708288815720678 1.789062549140905 0.0736047426948065 1.0 0.5937553332614636 4 P49840 1 +Dna packaging 0.425431432519935 1.7886351058906595 0.073673600262297 1.0 0.5937553332614636 82 O75151,P10412,P12270,Q9H7Z3,P07305,O95831,Q8NEY8,P25440,O43823,P53350,P06493,P24941,P46100,Q01105 14 +Response to zinc ion 0.7934201232870023 1.7874624007948032 0.0738627838690795 1.0 0.5945302918227798 5 P09874,P30536,Q8TAD4 3 +Lipoprotein localization 0.7211939035678454 1.7833728160711773 0.0745256352893768 1.0 0.5965154344221825 7 O15260 1 +Peripheral nervous system axon regeneration 0.868211321425302 1.7790155820064653 0.0752372073732339 1.0 0.6003008643225193 4 Q96G23 1 +Steroid metabolic process 0.4262015135226792 1.7770956059750866 0.0755525110138428 1.0 0.6018094088926895 62 P34913,P35610,O15118,P37268,Q15392,Q16850,P28288,Q9UBM7,Q14739,Q9H4L5,P30536,Q15126,Q8WTV0,Q9UHB6 14 +Response to axon injury 0.5817467293130107 1.7767182545707778 0.0756146073135393 1.0 0.6018094088926895 16 P06493,Q96G23 2 +Chloride transport 0.5916575123703136 1.7758942399681783 0.0757503505341943 1.0 0.6021399132637263 14 P08183,Q9UHG3 2 +Amyloid beta clearance 0.7060216286486523 1.7740942699912503 0.0760475584358038 1.0 0.6037514856685988 8 Q16850,P20339 2 +Protein lipid complex subunit organization 0.7539810827636179 1.7721950065634338 0.0763621922399035 1.0 0.6047469276396826 6 Q8WTV0,P35610 2 +Response to retinoic acid 0.6110636154089344 1.7664202317649906 0.0773253733094794 1.0 0.6081746127014301 13 O94788 1 +Regulation of dna methylation 0.7168925462866329 1.7642794922669154 0.0776849349383967 1.0 0.6081746127014301 7 O75844,P09874,Q8NB78 3 +Muscle cell differentiation 0.4433684042514792 1.758589178885919 0.0786473122852697 1.0 0.6125319316288281 58 P49840,Q7Z4V5,P41440,P06493,P67809,Q8NEZ5,O75844 7 +Synaptonemal complex organization 0.784780110366903 1.752292392170241 0.0797235435499397 1.0 0.6151204156428831 5 Q92791 1 +Glucan biosynthetic process 0.7009442833380741 1.7510496954917718 0.0799373501985667 1.0 0.6151204156428831 8 P49840 1 +Homologous chromosome pairing at meiosis 0.7005458453844987 1.7492392904786476 0.0802496650815851 1.0 0.6151204156428831 8 Q92791 1 +Guanine nucleotide transmembrane transport 0.8602252809832547 1.7483169617127108 0.0804091577559238 1.0 0.6151204156428831 4 Q8TDW0,P41440 2 +Guanine nucleotide transport 0.8602252809832547 1.7483169617127108 0.0804091577559238 1.0 0.6151204156428831 4 Q8TDW0,P41440 2 +Protein targeting to mitochondrion 0.4803880549096823 1.7470173762450476 0.0806343240348534 1.0 0.6151204156428831 48 P55786,Q99595,Q9NS69,P49840,O95831,O60830 6 +Mitochondrial outer membrane permeabilization involved in programmed cell death 0.6671920274939185 1.746232907828221 0.0807704887534366 1.0 0.6151204156428831 10 P49840 1 +Fibroblast proliferation 0.6273136706885963 1.7454734524108717 0.0809024896419359 1.0 0.6151204156428831 12 O75844,P14174 2 +Collagen biosynthetic process 0.8594682319546616 1.745403316036097 0.0809146888694232 1.0 0.6151204156428831 4 Q92791 1 +Mitochondrial outer membrane permeabilization 0.6865480229493337 1.7450573498430213 0.0809748866366555 1.0 0.6151204156428831 9 P49840 1 +Negative regulation of keratinocyte proliferation 0.858086321418749 1.740083225117887 0.081844405339043 1.0 0.6203910747412498 4 Q9Y3B8 1 +Lipopolysaccharide mediated signaling pathway 0.6984254753043203 1.739599961416541 0.081929286039996 1.0 0.6203910747412498 8 P17252,Q8WTV0,P14174 3 +Regulation of carbohydrate biosynthetic process 0.5751387897683057 1.7380828089439284 0.0821962235653603 1.0 0.6216758163387197 16 P49840 1 +Mitotic g2 dna damage checkpoint signaling 0.6842257869640714 1.7342637182805531 0.0828713018746343 1.0 0.624145432630692 9 P06493 1 +Polysaccharide biosynthetic process 0.6246676889962182 1.7317074529334584 0.0833256629928067 1.0 0.6256524798304213 12 P49840 1 +Blood vessel endothelial cell migration 0.5406252602127195 1.724878747621563 0.084549326317064 1.0 0.6262603618181757 21 P42785,Q8WTV0,P17252,P06576 4 +Negative regulation of cell cycle g2 m phase transition 0.5547596776028664 1.7241022656781406 0.084689383155871 1.0 0.6262603618181757 19 Q96GD4,Q9Y619,P53350,P06493,Q68E01 5 +Glandular epithelial cell development 0.8529682924809796 1.7203625798526976 0.0853665545561146 1.0 0.6263807694237986 4 P49840 1 +Enteroendocrine cell differentiation 0.8529682924809796 1.7203625798526976 0.0853665545561146 1.0 0.6263807694237986 4 P49840 1 +Spindle midzone assembly 0.7414152093610794 1.7187541105828634 0.0856591546029459 1.0 0.6270878087828493 6 Q96GD4,Q9H0H5 2 +Regulation of glial cell proliferation 0.7756533536036752 1.7150325095162788 0.0863392667462854 1.0 0.6284542734955738 5 P30536,Q96G23 2 +Aspartate family amino acid metabolic process 0.5388376549203326 1.7132504660280623 0.086666470931509 1.0 0.6284542734955738 21 Q9BQT8,O75600,Q13126,P30520 4 +Regulation of transcription elongation from rna polymerase ii promoter 0.5802030469360483 1.7112272453358914 0.0870391709850462 1.0 0.6284542734955738 14 Q9H3P2,Q14004 2 +Response to increased oxygen levels 0.6599281320629459 1.7111839922832832 0.0870471527864356 1.0 0.6284542734955738 10 P00846 1 +Organelle disassembly 0.4761980817315566 1.7107668748595948 0.0871241568325893 1.0 0.6284542734955738 48 P06493,P49840,P27544,Q96HY6 4 +Mitotic cell cycle checkpoint signaling 0.498143151454698 1.703088634122727 0.0885514826256563 1.0 0.6351655729074859 39 Q96GD4,Q9Y619,P49454,P53350,P06493,P24941,Q68E01 7 +Xenobiotic transport 0.7375367040510475 1.7022113223045765 0.0887157610527 1.0 0.6356305256589755 6 P08183,P41440 2 +Negative regulation of blood pressure 0.8478037180440691 1.7004356621183718 0.0890490086177369 1.0 0.637303711171284 4 P42785 1 +B cell apoptotic process 0.7018169118085049 1.6971041949401189 0.0896769632764846 1.0 0.638935866555199 7 Q96GD4,P00813,P14174 3 +Triglyceride biosynthetic process 0.8458892849465213 1.693042323830006 0.0904474113573394 1.0 0.6394351836114565 4 Q8WTV0,P33121 2 +Carboxylic acid transport 0.5032150303395972 1.6901068054672537 0.0910075231495284 1.0 0.64049215437404 35 Q9Y619,Q9BQT8,Q8TDW0,O15439,P41440,P30825,P14174,P53985 8 +Nerve development 0.6874627873770418 1.6896339435914804 0.0910980078745113 1.0 0.64049215437404 8 Q9H061,P42892 2 +Regulation of chromatin assembly or disassembly 0.56955581067845 1.6763141183734154 0.0936766809164695 1.0 0.6435591647566489 15 P12270,P24941,Q8NEY8 3 +Autophagy of mitochondrion 0.5054916167104154 1.6727400753460908 0.0943784762705413 1.0 0.6435591647566489 31 Q96CV9,P21796,P49840,P27544,P30536 5 +Signal transduction in response to dna damage 0.4747990144046662 1.6725139169324803 0.0944230258990879 1.0 0.6435591647566489 47 Q96RU2,P14174,P53350,P06493,P24941,P46100,O75844 7 +Peroxisome organization 0.6512988210295434 1.6694121097908212 0.095035735346743 1.0 0.6435591647566489 10 P28288,Q9GZY8,O75381 3 +Positive regulation of mitochondrial translation 0.6952005029351935 1.6675004995682854 0.0954149251625458 1.0 0.6435591647566489 7 Q567V2 1 +Columnar cuboidal epithelial cell development 0.7291240273023699 1.6662539758691746 0.0956628393864522 1.0 0.6435591647566489 6 P49840 1 +Phosphatidylcholine catabolic process 0.986623164763458 1.6633903894897175 0.0962343156219971 1.0 0.6460436041388484 2 Q8WTV0 1 +Negative regulation of carbohydrate metabolic process 0.6299103780736706 1.6614502647416949 0.0966230498163485 1.0 0.6472746789153327 11 P49840 1 +Negative regulation of response to food 0.9856443719412724 1.659517192084908 0.0970116192517991 1.0 0.6472746789153327 2 Q9UMX5 1 +Regulation of response to food 0.9856443719412724 1.659517192084908 0.0970116192517991 1.0 0.6472746789153327 2 Q9UMX5 1 +Regulation of appetite 0.9856443719412724 1.659517192084908 0.0970116192517991 1.0 0.6472746789153327 2 Q9UMX5 1 +Regulation of glycogen starch synthase activity 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.6472746789153327 2 P49840 1 +Response to interleukin 3 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.6472746789153327 2 P49840 1 +Regulation of type b pancreatic cell development 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.6472746789153327 2 P49840 1 +Negative regulation of glycogen metabolic process 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.6472746789153327 2 P49840 1 +Response to l glutamate 0.8348595724353589 1.650378507747982 0.0988655441061734 1.0 0.6529228115030771 4 O95831 1 +Cellular response to hydrogen peroxide 0.5287956348385803 1.647741324352025 0.0994057641652603 1.0 0.6529228115030771 21 Q99720,O95831 2 +Positive regulation of b cell proliferation 0.8339457926290492 1.6468388737437372 0.0995911687406572 1.0 0.6529228115030771 4 P14174 1 +Response to catecholamine 0.5539413317033621 1.6445847827414246 0.1000554671019933 1.0 0.6529228115030771 17 P49840 1 +Negative regulation of mitotic cell cycle phase transition 0.4866637565499067 1.644215236977529 0.1001317506694177 1.0 0.6529228115030771 41 Q96GD4,Q9Y619,P49454,Q96K76,Q6IQ49,P53350,P06493,P24941,Q68E01 9 +Regulation of rna polymerase ii regulatory region sequence specific dna binding 0.9817292006525284 1.6440208813694874 0.1001718891731335 1.0 0.6529228115030771 2 Q96HY6 1 +Regulation of intracellular protein transport 0.3953917593470195 1.64018946961901 0.1009657781301596 1.0 0.6529228115030771 68 Q9Y282,Q14978,P55786,Q9Y3B8,O00459,Q9GZY8,P12270,P49840,P49841,P17252,Q9NPF5,P06493,P50402 13 +Muscle hypertrophy 0.5584613021146113 1.6400504287672657 0.10099468212202 1.0 0.6529228115030771 16 Q12792,P09874,P49840,Q13464,P17252 5 +Mitochondrial ribosome assembly 0.8321896230482666 1.6400340381622502 0.1009980898564804 1.0 0.6529228115030771 4 Q567V2 1 +Protein localization to mitochondrion 0.4178833872485986 1.6398782500365878 0.1010304839946925 1.0 0.6529228115030771 61 P55786,Q99595,Q9NS69,P49840,O95831,O60830 6 +Cellular response to inorganic substance 0.4964421363195586 1.6384667926091443 0.1013243557883027 1.0 0.6529228115030771 35 P24941,P30536,P46100,O95831 4 +Regulation of b cell proliferation 0.6887042632547153 1.6383651093325524 0.1013455529668365 1.0 0.6529228115030771 7 P00813,P14174 2 +Response to endoplasmic reticulum stress 0.405923076394617 1.6368624747040583 0.1016592082645915 1.0 0.6538657361108432 77 Q13217,Q7L5D6,Q8TCJ2,O00459,P07237,P49841,O95831,O95881,Q96HY6,P41440,Q9UBU6,Q8IXB1,Q7Z2K6,P13667 14 +Positive regulation of cell cycle process 0.3961634426138088 1.635133857535754 0.1020209899313957 1.0 0.6538657361108432 69 Q96GD4,Q96DY7,Q96HY6,P06493,P46100 5 +Energy reserve metabolic process 0.5624094126493657 1.6349680396612312 0.1020557476926196 1.0 0.6538657361108432 15 P49840 1 +Dna damage response signal transduction by p53 class mediator 0.5574942065302875 1.6343439188321027 0.1021866567122522 1.0 0.6538657361108432 16 O75844,P14174 2 +Maintenance of dna repeat elements 0.8306953431411439 1.6342418187461314 0.1022080848653939 1.0 0.6538657361108432 4 O75844 1 +Regulation of dna replication 0.4782944928342187 1.63284442338446 0.1025017213471763 1.0 0.6550885011298043 44 P06493,P24941,O75844 3 +Intrinsic apoptotic signaling pathway in response to dna damage 0.5189489558143981 1.6322462946444298 0.1026276118511013 1.0 0.655237829510878 22 P61978,Q9Y3B8,Q96RU2,P09601,Q9BVC6,P14174,Q8N163,Q96K76,P46379 9 +Cytochrome complex assembly 0.5859538906245788 1.6300342917887216 0.1030942496247844 1.0 0.6562503479601567 13 Q69YU5,Q5U5X0 2 +Negative regulation of leukocyte migration 0.7198429953775366 1.6264698481447262 0.103849742521735 1.0 0.6595652946320871 6 P00813,P14174 2 +Positive regulation of double strand break repair via homologous recombination 0.5507350383302957 1.625297734401716 0.1040991339606296 1.0 0.6595652946320871 17 Q9NV56,P09874,Q7Z4V5,P35637,Q9UBU8 5 +Cellular response to biotic stimulus 0.4957193241670599 1.6231673714206556 0.1045536307829455 1.0 0.6595652946320871 34 P07948,P08670,P49841,P17252,O43823,P30536,P14174,O75844,Q8WTV0 9 +Collagen metabolic process 0.6603359554421042 1.6226494375808465 0.1046643658242576 1.0 0.6595652946320871 9 Q32P28,Q92791 2 +Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.6218019356049981 1.6205047945462183 0.1051238852368279 1.0 0.6595652946320871 11 P61978,Q9BVC6,Q96RU2,P14174 4 +Anterior posterior pattern specification 0.5841622365590781 1.6202482375608178 0.1051789631854833 1.0 0.6595652946320871 13 P80723,O94788 2 +Urogenital system development 0.490903894499922 1.6185800236034975 0.1055376560955818 1.0 0.6595652946320871 37 P35610,O94788,P49454,O75844,P39210 5 +Positive regulation of cell cycle g1 s phase transition 0.5538838374272581 1.61302029872182 0.1067400978285295 1.0 0.6595652946320871 16 Q96HY6 1 +Positive regulation of intracellular protein transport 0.4446269576942017 1.612467925718355 0.1068601540842915 1.0 0.6595652946320871 54 Q9Y282,P55786,Q9Y3B8,O00459,Q9GZY8,P12270,P49840,P49841,Q9NPF5,P06493,P50402 11 +Microtubule anchoring 0.6389481440421083 1.6093830170759895 0.1075326164613761 1.0 0.6595652946320871 10 P49841,O75381,Q8TD16,O95684 4 +Glomerulus development 0.8239667986317839 1.60813626468086 0.1078053382877457 1.0 0.6595652946320871 4 P39210 1 +Terpenoid metabolic process 0.5357924340557464 1.605547432658022 0.1083733833907956 1.0 0.660966241307219 19 Q9HB40,P37268,O94788 3 +Regulation of anaphase promoting complex dependent catabolic process 0.9716150081566052 1.6039657474147402 0.1087216029235733 1.0 0.660966241307219 2 P24941 1 +Peptidyl serine modification 0.4357685012047964 1.601908353970733 0.1091758768926078 1.0 0.660966241307219 56 Q96GD4,P09874,P49841,P14174,P53350,P06493,P24941 7 +Positive regulation of establishment of protein localization to mitochondrion 0.5998032458423941 1.6016029574286306 0.1092434364224876 1.0 0.660966241307219 12 P49840 1 +Cellular glucan metabolic process 0.5800516885466447 1.597770754459417 0.1100940055501458 1.0 0.6634026131105283 13 P49840 1 +Negative regulation of neuron projection development 0.5340751373969419 1.594765096138561 0.1107647749983105 1.0 0.6634800026965749 19 Q96G23,P08670,Q9NR77,Q8N5V2,Q9NQX7 5 +Embryonic digit morphogenesis 0.8195973763407168 1.591163407623377 0.1115728056321707 1.0 0.6634800026965749 4 P42892 1 +Epoxide metabolic process 0.9683523654159844 1.5910387942168545 0.1116008453917725 1.0 0.6634800026965749 2 P07099 1 +Nucleosome positioning 0.6532835214867998 1.5895099234505603 0.1119453154623171 1.0 0.6642920251807509 9 P10412,P07305,Q92522,P16402,P16403,Q8N7H5 6 +Nephron development 0.5773851859502505 1.5831710454370036 0.1133824840268364 1.0 0.6644686695551034 13 P80723,P39210,Q12769,P35610 4 +Cellular metabolic compound salvage 0.6334089113517343 1.582371756278857 0.1135647284579448 1.0 0.6644686695551034 10 P55263,Q13126 2 +Regulation of muscle hypertrophy 0.5957555233177786 1.5803034085378775 0.114037399660543 1.0 0.6644686695551034 12 P49840,P09874,P17252,Q12792 4 +Cellular response to zinc ion 0.9654159869494284 1.5794025214065806 0.1142437594057672 1.0 0.6644686695551034 2 P30536 1 +Regulation of stem cell differentiation 0.5429886639065696 1.5785962236014313 0.1144287014197806 1.0 0.6644686695551034 17 P49841,Q96PZ0,Q14004 3 +Negative regulation of striated muscle cell differentiation 0.8156405269969654 1.5757800070224026 0.1150765115133172 1.0 0.6644686695551034 4 P49840 1 +Negative regulation of dna recombination 0.5474826446631224 1.5751382098694768 0.1152245459999172 1.0 0.6644686695551034 16 P10412,Q6NSI4,P07305,Q9NYB0,P20585,P16403 6 +Cartilage development involved in endochondral bone morphogenesis 0.8151744699537689 1.573967274167405 0.1154950154130745 1.0 0.6644686695551034 4 O75844 1 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.7399736378108209 1.5683884035500326 0.1167905157858864 1.0 0.666765878487998 5 O15460,P13674,P07237 3 +Membrane protein proteolysis 0.5930545917330653 1.566073554754711 0.1173313983322947 1.0 0.666953665653257 12 Q9Y4W6,P38159,Q16740 3 +Regulation of muscle cell differentiation 0.5348232999265754 1.5623052329069969 0.1182160998513786 1.0 0.6688357254566613 18 P49840,Q8NEZ5 2 +Tetrapyrrole metabolic process 0.5157399092435664 1.5621289780343035 0.11825760753654 1.0 0.6688357254566613 21 P50336,P36551,P22830,P30519,P30536,Q9UII2 6 +Protein targeting to peroxisome 0.8117415252298816 1.5606097442278974 0.1186158582494605 1.0 0.6690728279031483 4 O75381 1 +Isoprenoid biosynthetic process 0.6712558463368309 1.559787202369973 0.1188101767216234 1.0 0.6690728279031483 7 O94788 1 +Meiotic cell cycle process 0.4883773891823338 1.5592028397499769 0.1189483789481575 1.0 0.6690728279031483 33 P53350,P46100,Q92791 3 +Nuclear pore complex assembly 0.646796708041823 1.5589570454080284 0.1190065471412684 1.0 0.6690728279031483 9 Q8WYP5,Q9BTX1 2 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.7035974482684462 1.5565589477254198 0.1195752369142821 1.0 0.6690728279031483 6 P14174 1 +Spindle elongation 0.6705347871719036 1.556530342379021 0.1195820332708432 1.0 0.6690728279031483 7 Q96GD4 1 +Regulation of glucose metabolic process 0.4998682742626176 1.555464846229993 0.1198354005912545 1.0 0.6690728279031483 23 O75844,P49840,P49841 3 +Amp biosynthetic process 0.5908731562863722 1.554570832906204 0.1200483147624829 1.0 0.6690728279031483 12 P11908,P55263,P30520 3 +Negative regulation of cell cycle phase transition 0.4043779512186607 1.5472228275166475 0.1218095232616505 1.0 0.6707569088599048 62 Q96GD4,Q9Y619,Q96RU2,P49454,Q96K76,Q6IQ49,Q8N6R0,P53350,P06493,P24941,Q68E01 11 +Regulation of hormone levels 0.3870496543063252 1.5458938579577075 0.1221302041621452 1.0 0.6707569088599048 68 O94788,Q9HB40,P53985,Q8TAD4,P30536,O75844,P42892 7 +Positive regulation of mitophagy 0.7343939079961408 1.5453283144459111 0.1222668700383988 1.0 0.6707569088599048 5 P27544 1 +Negative regulation of nuclear division 0.5371795097678569 1.5434821489546893 0.1227138354192316 1.0 0.6707569088599048 17 Q96GD4,P12270,P49454,Q96DY7,P53350 5 +Circulatory system process 0.3947455267185454 1.5378498273463967 0.1240853372146466 1.0 0.6723315022374722 75 Q9HB40,P53985,P49840,P08183,O15439,Q99808,P42785,P30825,P41440,O75844,P42892,Q16625 12 +Positive regulation of nf kappab transcription factor activity 0.4972137047187995 1.537146012944275 0.124257557336417 1.0 0.6724098241358649 23 P41440 1 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.6051357868362853 1.5359616062824617 0.1245477970391837 1.0 0.6724098241358649 11 P61978,P14174 2 +Amyloid precursor protein biosynthetic process 0.7320031356434131 1.5354382776098383 0.1246762074168361 1.0 0.6724098241358649 5 Q9NQX7 1 +Er overload response 0.8051303042889939 1.534861428163902 0.1248178699125255 1.0 0.6725967460918338 4 P49841 1 +Positive regulation of amyloid precursor protein catabolic process 0.6982015990228383 1.5332670474380243 0.1252100703103253 1.0 0.6725967460918338 6 P49840,Q96S59 2 +Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.80426510877342 1.5314895484424984 0.1256484475411998 1.0 0.6725967460918338 4 P49840 1 +Positive regulation of intracellular transport 0.389401660260646 1.53145071964502 0.1256580370573696 1.0 0.6725967460918338 71 Q9Y282,P55786,Q9Y3B8,O00459,Q9GZY8,P12270,Q9H7Z3,P49840,P49841,Q9NPF5,P06493,P50402 12 +Nuclear pore organization 0.5863437770568962 1.530660129432703 0.1258534125082626 1.0 0.6727949332369716 12 Q9BTX1,Q8WYP5,P12270,P49790,Q8NFH5,Q7Z3B4 6 +Mesenchymal cell differentiation 0.4854792055231851 1.530355410475565 0.1259287796606532 1.0 0.6727949332369716 32 O94788,Q13428,P49841,Q14978,P98172 5 +Stem cell differentiation 0.4725560658568601 1.530023629382092 0.1260108801571984 1.0 0.6727949332369716 41 Q14004,O94788,Q13428,P49841,P08133,Q14978,P98172 7 +Regulation of cell aging 0.5672607905380816 1.527610786418943 0.1266092020719913 1.0 0.6734195126675977 13 O75844,P14174 2 +B cell proliferation 0.622210020118648 1.5276054971102986 0.1266105161074122 1.0 0.6734195126675977 10 P00813,P14174 2 +Positive regulation of fatty acid transport 0.9520391517128852 1.5263757489910366 0.1269163136312492 1.0 0.6734195126675977 2 P14174 1 +Apoptotic mitochondrial changes 0.484925467790376 1.5262033083391695 0.1269592398121188 1.0 0.6734195126675977 32 Q9Y3B8,P49840,P49841,Q96A26,Q9GZY8 5 +Regulation of nuclear cell cycle dna replication 0.974587569087447 1.524699918830159 0.1273339620191378 1.0 0.6734195126675977 3 O75844 1 +Response to vitamin 0.5447105209148022 1.508863610442558 0.1313336409081031 1.0 0.680190503103188 14 O94788 1 +Isoprenoid metabolic process 0.5002863075587349 1.5067160587985915 0.1318834535127553 1.0 0.6818798324983931 22 Q6NUM9,Q9BY49,O94788,O60762,Q9HB40,P37268,Q9BTZ2,Q15126 8 +Cellular response to amyloid beta 0.7248759800925806 1.5059232500263893 0.1320868772700689 1.0 0.6818798324983931 5 P49841 1 +Response to amyloid beta 0.7248759800925806 1.5059232500263893 0.1320868772700689 1.0 0.6818798324983931 5 P49841 1 +Regulation of ubiquitin dependent protein catabolic process 0.4433863799377064 1.504316839741609 0.1324998051449064 1.0 0.6821643239356268 51 P49840,P49841,Q96HY6,P53350,P24941 5 +Purine nucleoside monophosphate biosynthetic process 0.5435444202204692 1.5021703269617344 0.1330531260297855 1.0 0.6830060469528993 14 P55263,P11908,P30520 3 +Negative regulation of chromosome organization 0.4758550110919904 1.501092189284858 0.1333317187549418 1.0 0.6834942034401994 37 Q96GD4,P49454,P12270,P09874,Q9NYB0,P09651,P25054,P53350,P46100,P84243 10 +Positive regulation of protein export from nucleus 0.561293049646935 1.49477300368364 0.1349736941469435 1.0 0.6891145303453666 13 P12270,P50402,Q9Y3B8,P49841 4 +Negative regulation of response to external stimulus 0.4640349756213221 1.4946804044514042 0.1349978707545609 1.0 0.6891145303453666 43 Q96G23,O14936,Q9UMX5,P28070,P80303,P00813,P14174 7 +Prostaglandin transport 0.9435562805872726 1.4927425399971697 0.1355045933515231 1.0 0.6900476941112224 2 P14174 1 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.7935755963368291 1.4897900997367304 0.1362794350804843 1.0 0.6919468971703637 4 P30536 1 +Regulation of cyclin dependent protein kinase activity 0.558418541714834 1.478934216862117 0.1391578972457581 1.0 0.6977745761802628 13 P53350,Q9Y3B8,P25054 3 +Regulation of leukocyte proliferation 0.4809385854023288 1.4786117998759718 0.1392440971910629 1.0 0.6977745761802628 24 P07948,P00813,P04439,P30825,P14174,P98172 6 +Polysaccharide metabolic process 0.5263930361037825 1.4780919112498978 0.1393831788401653 1.0 0.6977745761802628 17 P49840 1 +Connective tissue development 0.4886038220243355 1.4776021404496282 0.1395143011132773 1.0 0.6977745761802628 23 Q9NX62,P35610,Q96HY6,P08133,O75844 5 +Nephron epithelium development 0.652687714599844 1.4756969786157184 0.1400252574302583 1.0 0.6980461067192855 7 P35610 1 +Bone remodeling 0.6287429461935747 1.4735917942380186 0.1405915320552395 1.0 0.6980461067192855 9 O14773,Q92791 2 +Regulation of amyloid beta clearance 0.7889901790774504 1.4718817134815836 0.1410528225066634 1.0 0.6980461067192855 4 Q16850 1 +Organic hydroxy compound catabolic process 0.5919349671122114 1.4686667349971798 0.1419232042882763 1.0 0.6980461067192855 11 P30837,Q10713,Q8WTV0 3 +Response to aldosterone 0.958930996598067 1.4684612716392236 0.1419789687201609 1.0 0.6980461067192855 3 O95831 1 +Response to hydrogen peroxide 0.4793879288796763 1.4684299042282865 0.1419874835719725 1.0 0.6980461067192855 28 Q99720,O95831,P06493 3 +Dna methylation 0.5247925189470413 1.468369790625361 0.1420038028277348 1.0 0.6980461067192855 17 Q9NPF5,O75844,P09874,P46100 4 +Positive regulation of pattern recognition receptor signaling pathway 0.638897088136452 1.465929188802703 0.1426675790362646 1.0 0.6980461067192855 8 P41440 1 +Columnar cuboidal epithelial cell differentiation 0.6095458596703027 1.4654414523525123 0.142800514945701 1.0 0.6980461067192855 10 P49840 1 +Neuron projection regeneration 0.5910818051042942 1.4643084576994951 0.1431096873096202 1.0 0.6980461067192855 11 Q96G23 1 +Positive regulation of transcription regulatory region dna binding 0.6819744868934251 1.4630281668273568 0.1434596717985532 1.0 0.6980461067192855 6 Q96HY6,P09874 2 +Ornithine transport 0.9360522022838462 1.4629924589987782 0.1434694424096485 1.0 0.6980461067192855 2 P30825 1 +Negative regulation of cell cycle g1 s phase transition 0.5554480476713036 1.4625525118100748 0.1435898655462109 1.0 0.6980461067192855 13 P24941,Q8N6R0 2 +Positive regulation of chromosome segregation 0.6816709740277074 1.4617118690575135 0.143820183368375 1.0 0.6980461067192855 6 Q96GD4,Q14980,Q8IY18 3 +Intracellular lipid transport 0.5732779878744163 1.4614930943156943 0.143880169318288 1.0 0.6980461067192855 12 P28288,P23786,O43772 3 +Dna templated transcription termination 0.6379214257719701 1.4614007728429423 0.1439054887419093 1.0 0.6980461067192855 8 O75844 1 +Epigenetic maintenance of chromatin in transcription competent conformation 0.7140420897127524 1.46097358407621 0.144022690943625 1.0 0.6980461067192855 5 O14497,O75151 2 +Positive regulation of cell cycle phase transition 0.4640059066701035 1.460492986926484 0.144154633570763 1.0 0.6980461067192855 41 P06493,Q96HY6 2 +Forelimb morphogenesis 0.9563590870917372 1.4592193489725358 0.1445047449476124 1.0 0.6980461067192855 3 O94788 1 +Receptor recycling 0.6475320175634477 1.4522717438735175 0.1464260609332655 1.0 0.7030871190266715 7 P42892,Q96CV9 2 +Keratinization 0.9327895595432264 1.4500596771207914 0.1470418783097895 1.0 0.7048729947887412 2 Q9Y3B8 1 +Response to xenobiotic stimulus 0.3773315977499082 1.4493200526430337 0.1472482235966032 1.0 0.7048729947887412 67 P07099,P49454,P08183,P33121,P27544,P30536,P06493,P46100 8 +Myotube differentiation 0.5341668052903599 1.4482579321528295 0.1475449280622007 1.0 0.7048729947887412 14 P41440 1 +Mitotic g1 s transition checkpoint signaling 0.645961024753233 1.4451278061825803 0.1484219898938565 1.0 0.7053745309101728 7 P24941 1 +Alcohol catabolic process 0.6048736994346088 1.442451046618638 0.1491751721520311 1.0 0.7056225570618945 10 P30837,Q10713,Q8WTV0 3 +Bile acid and bile salt transport 0.9308319738988572 1.4423008687989465 0.1492175152106805 1.0 0.7056225570618945 2 O15439 1 +Cellular carbohydrate biosynthetic process 0.5328856993715242 1.4408816410704106 0.149618123539629 1.0 0.7056225570618945 14 P49840 1 +B cell homeostasis 0.7086850320264864 1.4387133454923329 0.1502317566053932 1.0 0.7056225570618945 5 P00813,P14174 2 +Membrane lipid metabolic process 0.4677155129026259 1.426935244785288 0.1535985606452166 1.0 0.7124188668627263 36 Q06136,Q8NCC3,Q96G23,Q8NBX0 4 +Regulation of lipid localization 0.4808522985719666 1.4238430699984532 0.1544919047749002 1.0 0.7124188668627263 23 O15260,Q8WTV0,P30536,P14174 4 +Regulation of triglyceride metabolic process 0.9252854812397988 1.4203220427122496 0.1555139467542377 1.0 0.7124188668627263 2 Q8WTV0 1 +Mrna cis splicing via spliceosome 0.5214373410783464 1.420131292741897 0.1555694615885405 1.0 0.7124188668627263 16 O43290,O75400,Q9P013,Q96I25,Q15459,Q09161,Q07955 7 +Olefinic compound metabolic process 0.4998166681946281 1.4154759921693332 0.1569289826183086 1.0 0.7124188668627263 20 P07099,Q9H7Z7,O94788 3 +Mitotic nuclear membrane disassembly 0.7735873617158227 1.4116500394366749 0.1580530307507588 1.0 0.7124188668627263 4 P53350 1 +Cell cycle dna replication 0.5102900796356302 1.4104224117929502 0.1584149915568837 1.0 0.7124188668627263 18 O75844 1 +Icosanoid transport 0.9419422842778342 1.4074067689002232 0.1593068051879882 1.0 0.7124188668627263 3 P14174 1 +Cellular senescence 0.4985188491181296 1.4070663647818196 0.1594077107217528 1.0 0.7124188668627263 20 O75844,P24941 2 +Retinoic acid metabolic process 0.9414740476955076 1.4057239578430805 0.1598061099348333 1.0 0.7124188668627263 3 O94788 1 +Negative regulation of glial cell proliferation 0.9411212815655916 1.4044561463264775 0.1601830616727464 1.0 0.7124188668627263 3 Q96G23 1 +Regulation of heart growth 0.6367581123717423 1.4032255737881554 0.1605495838193513 1.0 0.7124188668627263 7 P49840 1 +Skeletal system morphogenesis 0.5259653179425371 1.4009942553665646 0.1612157909649787 1.0 0.7124188668627263 14 O75844,P08133 2 +Regulation of cell cycle g1 s phase transition 0.4680268390523359 1.3991020813239694 0.1617823736841781 1.0 0.7126106019741115 32 Q96DY7,P24941,Q96HY6,Q8N6R0 4 +Regulation of chromatin organization 0.5030885528116693 1.399060440840188 0.1617948591760718 1.0 0.7126106019741115 19 P12270,P24941,Q8NEY8 3 +Cellular response to xenobiotic stimulus 0.4694540095705026 1.3968879181753966 0.1624472783247319 1.0 0.7140306435855308 24 P07099,P27544 2 +Negative regulation of dna metabolic process 0.4557974955381301 1.3935543353904971 0.1634522262518598 1.0 0.7147944985536177 41 P10412,Q6NSI4,Q92878,Q03164,P07910,P07305,P09874,Q9NYB0,P09651,P20585,P16403,P27544,Q99543 13 +Regulation of mitochondrial gene expression 0.5948373928002674 1.3929739895492692 0.1636276562954064 1.0 0.7147944985536177 10 Q567V2,Q6P087 2 +Regulation of neuron projection development 0.3745800766348485 1.3904978504485328 0.1643777515938498 1.0 0.7170909286254568 69 Q12792,Q96G23,Q9NR77,P49840,P49841,Q32P28,Q8N5V2,Q9NQX7,P53990 9 +Signaling receptor ligand precursor processing 0.767650932834552 1.388410749761316 0.1650120048555539 1.0 0.7188764301512235 4 P42892 1 +Modification of postsynaptic structure 0.664402721732092 1.3866889714134731 0.1655366249718577 1.0 0.7189564521533004 6 P35080,Q9UQB8,P60953 3 +Triglyceride metabolic process 0.6218184259046873 1.3865046907636496 0.1655928489390796 1.0 0.7189564521533004 8 Q8WTV0,P33121,Q96N66 3 +Nucleoside metabolic process 0.5062495537197728 1.3853046612477016 0.1659593290488892 1.0 0.7195295143618262 18 P11908,Q13126,P55263,O60725 4 +Positive regulation of double strand break repair 0.4822991553230429 1.3849287501484142 0.1660742549044214 1.0 0.7195295143618262 22 Q9NV56,P09874,Q7Z4V5,P35637,Q9UBU8 5 +Regulation of lipid transport 0.5110351050377074 1.3846244228681537 0.1661673395508403 1.0 0.7195295143618262 17 O15260,P30536,P14174 3 +Positive regulation of protein import 0.5001479118636359 1.380394048993819 0.1674653514800694 1.0 0.7203362069081551 19 Q9NPF5,P06493,O00459 3 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.7655106309561639 1.3800294554051586 0.167577575796032 1.0 0.7203362069081551 4 P53350 1 +Sterol biosynthetic process 0.4811763002014232 1.3773055209264138 0.1684178090343966 1.0 0.7208101469312906 22 Q15392,P37268,Q16850,Q14739,Q15126 5 +Negative regulation of mrna metabolic process 0.4474338540422712 1.3742672310418294 0.1693587355198977 1.0 0.7208101469312906 44 P61978,Q13242,Q92615,Q16629,P07910,O75494,P38159,P18615,Q92804,Q99729,P35637,Q13151,Q14011,P22626,P67809,P98175 16 +Regulation of mrna splicing via spliceosome 0.3880128836553843 1.3731644583054097 0.1697012260602981 1.0 0.7208101469312906 62 Q92841,P17844,P98179,P98175,Q08170,P51116,Q13595,Q96T37,Q16629,P19338,P84103,Q96PU8,Q8IY67,Q96E39,P22626,Q13242,Q14011,P61978,Q9BWF3,O75525,O75494,P38159,P09651,Q92879,P62995,Q9Y2W1 26 +Positive regulation of rna splicing 0.4660949682989418 1.3729333975118856 0.1697730528715011 1.0 0.7208101469312906 24 P19338,Q13243,Q13595,P38159,P98179,P62995,Q8WVV9,Q14011,Q9Y2W1 9 +Cardiac muscle tissue development 0.4659209096394125 1.3716915683981945 0.1701594743133314 1.0 0.7208101469312906 24 P06493,P49840,O94788 3 +Cartilage development 0.5386693385727971 1.3697847229859272 0.1707541122957652 1.0 0.7208101469312906 13 O75844,Q96HY6,P08133 3 +Regulation of cellular carbohydrate metabolic process 0.4660281410896915 1.3697825194108275 0.1707548003663512 1.0 0.7208101469312906 26 O75844,P49840,P49841 3 +Regulation of cholesterol metabolic process 0.659910966408318 1.3671365347516553 0.1715825135602644 1.0 0.7208101469312906 6 P34913 1 +Regulation of glucan biosynthetic process 0.9302220101917772 1.365290218777408 0.1721618520063816 1.0 0.7208101469312906 3 P49840 1 +Regulation of glycogen metabolic process 0.9302220101917772 1.365290218777408 0.1721618520063816 1.0 0.7208101469312906 3 P49840 1 +Bone development 0.4852550050478363 1.3606323229045938 0.1736299116029762 1.0 0.7236816870688954 21 Q32P28,O75844,P08133 3 +Positive regulation of t cell proliferation 0.5882330068265919 1.3603551950023878 0.1737175497311556 1.0 0.7236816870688954 10 P04439,P30825,P98172 3 +Regulation of mrna 3 end processing 0.502190258557193 1.3600472980859402 0.1738149569160936 1.0 0.7236816870688954 18 Q9H2U1,P09012,Q5VTR2,Q8N684,P18615,Q16630,Q8N7H5,Q09161,Q6PD62 9 +Mrna alternative polyadenylation 0.6896806536006124 1.3595965227465692 0.1739576391357198 1.0 0.7238042133570217 5 Q8N684 1 +Ribonucleoside monophosphate biosynthetic process 0.4967305061184469 1.3586859312190191 0.1742461320882831 1.0 0.7245328758465955 19 P11908,P55263,P30520 3 +Modification of synaptic structure 0.6257822179825924 1.3531448403834585 0.1760093629383297 1.0 0.7299648530427417 7 P35080,Q9UQB8,P60953 3 +Sulfur compound transport 0.5691409431492955 1.3519071023191342 0.1764050352210953 1.0 0.7311313749014398 11 Q70HW3,Q9H0H5,Q8TDW0 3 +Fatty acid beta oxidation using acyl coa oxidase 0.687650443419766 1.3511334722148365 0.1766526808930586 1.0 0.7314710195205918 5 O15254 1 +Purine nucleotide salvage 0.6873818137977421 1.3500135443891637 0.1770116383261224 1.0 0.7314710195205918 5 P55263 1 +Purine ribonucleotide salvage 0.6873818137977421 1.3500135443891637 0.1770116383261224 1.0 0.7314710195205918 5 P55263 1 +Amp salvage 0.6873818137977421 1.3500135443891637 0.1770116383261224 1.0 0.7314710195205918 5 P55263 1 +Mesenchyme development 0.4576482241380386 1.3484395105899074 0.1775170632571487 1.0 0.7314710195205918 36 O94788,Q13428,P49841,P08133,Q14978,P98172,P80723 7 +Regulation of response to wounding 0.4942820166895975 1.3431233554561102 0.1792320341229918 1.0 0.7343280036062103 19 Q96G23,Q16625 2 +Hepaticobiliary system development 0.4588875963826981 1.341975319178435 0.1796039982835324 1.0 0.7343280036062103 34 O75151,P35610,O94788,P00813,Q15418,O75844 6 +B cell activation involved in immune response 0.5082856183744812 1.3414403830722124 0.1797775136200081 1.0 0.7343280036062103 16 Q9UQ84 1 +Membrane raft organization 0.6118140417096902 1.3398445656572615 0.1802958834679888 1.0 0.7343280036062103 8 P41440 1 +Regulation of establishment of protein localization to mitochondrion 0.5029663941958578 1.3353840060872972 0.1817506967080302 1.0 0.7370359788458257 17 P49840 1 +Antiviral innate immune response 0.6837348095159625 1.3348062560884937 0.1819397654004142 1.0 0.7373348387279945 5 Q92667 1 +Regulation of platelet aggregation 0.7535464930600244 1.3331595351778338 0.1824794553542901 1.0 0.7379623282853799 4 P17252 1 +Regulation of platelet activation 0.7535464930600244 1.3331595351778338 0.1824794553542901 1.0 0.7379623282853799 4 P17252 1 +Positive regulation of map kinase activity 0.621211503467596 1.3322604825741668 0.1827746078731764 1.0 0.7379623282853799 7 Q15750,P14174 2 +Positive regulation of anion transport 0.6205924266703338 1.329430652975387 0.1837059304657442 1.0 0.7379623282853799 7 P08183 1 +Nucleotide salvage 0.6504453577957616 1.3258924103694465 0.1848753372973686 1.0 0.738923252449958 6 P55263 1 +Phospholipid dephosphorylation 0.7514524163666196 1.324953628937025 0.1851865318446059 1.0 0.7393706120352543 4 P34913 1 +Regulation of double strand break repair via homologous recombination 0.459198333521818 1.3200561448059172 0.1868162733859359 1.0 0.7438697764964269 27 Q9NV56,P09874,Q7Z4V5,P35637,Q9UBU8,Q9NPF5,Q9NY27 7 +Regulation of gliogenesis 0.5464490546969342 1.3187405314503364 0.1872558715206691 1.0 0.7444462037509361 12 Q96G23 1 +Regulation of smad protein signal transduction 0.6792824246709223 1.316234453408572 0.1880953631206408 1.0 0.7444594075539974 5 P09874 1 +Mitochondrial protein processing 0.6482106783072178 1.3161484309817315 0.1881242283210304 1.0 0.7444594075539974 6 Q10713,Q9Y4W6 2 +Methionine metabolic process 0.67888806635291 1.3145892170610824 0.1886479960003568 1.0 0.7456356811875894 5 Q13126 1 +Cell cycle checkpoint signaling 0.4158856204893775 1.3099096685530691 0.1902263959418799 1.0 0.7479260163486208 53 Q96GD4,Q9Y619,Q96RU2,P49454,P53350,P06493,P24941,Q68E01 8 +Regulation of circadian rhythm 0.4571880155162038 1.3093256028537623 0.190424080566713 1.0 0.7479260163486208 24 Q8WXF1,Q9BWF3,P23246,P49841,Q15233,P06493 6 +Regulation of skeletal muscle cell differentiation 0.7469800848841056 1.3074271837496796 0.1910676700852471 1.0 0.7479260163486208 4 Q9BYT8,Q9BRT2,Q92841 3 +Regulation of post translational protein modification 0.9135264867952434 1.30533772752529 0.1917778727318688 1.0 0.7479260163486208 3 O75718 1 +Positive regulation of protein deacetylation 0.6456157400276196 1.3048308049181558 0.1919504671653591 1.0 0.7479260163486208 6 P49354 1 +Sphingolipid biosynthetic process 0.4978923607809794 1.3043838861399402 0.1921027265225496 1.0 0.7479260163486208 17 Q06136,Q96G23 2 +Heart growth 0.5767276859856743 1.3034368563341057 0.1924256605690772 1.0 0.7479260163486208 10 P49840 1 +Protein processing 0.446298669712773 1.302275835688856 0.192822109059191 1.0 0.7479260163486208 40 Q5JRX3,Q9Y4W6,Q10713,P09874,Q6IQ49,Q15392,Q8TAD4,P17252,Q96F07,O75844,P42892 11 +Glial cell migration 0.5431846115419456 1.3013218403036662 0.1931483145101418 1.0 0.7479260163486208 12 Q96G23,P30536,Q96N66 3 +Skeletal muscle cell differentiation 0.5760105368723683 1.29988570028923 0.1936401468427733 1.0 0.7482189712649119 10 Q92841,Q9BRT2,O75446,Q9Y5Q8,Q9BYT8,P50402 6 +Dna integrity checkpoint signaling 0.4508336146914772 1.295208992225503 0.1952481436250841 1.0 0.7501027627361442 36 Q9Y619,Q96RU2,P53350,P06493,P24941 5 +Protein folding in endoplasmic reticulum 0.5911289032761934 1.294484453130063 0.1954981359874366 1.0 0.7501027627361442 9 Q13217,Q8IXB1,P07237 3 +Signal transduction in absence of ligand 0.5074432882060692 1.2939615295762126 0.1956787093912095 1.0 0.7501027627361442 14 P49840 1 +Response to acid chemical 0.4915365516378946 1.293670181969902 0.195779369138731 1.0 0.7501027627361442 18 P07948,Q6IAA8,O95831,Q9UQB8 4 +Primary alcohol metabolic process 0.4864585856947161 1.2933545626098617 0.1958884575266761 1.0 0.7501027627361442 19 O94788 1 +Positive regulation of mrna processing 0.4746596385106722 1.2902313717797127 0.1969703367658386 1.0 0.7503725187661342 21 P19338,Q13595,P38159,P98179,Q8N7H5,P62995,Q14011,Q9Y2W1 8 +Regulation of protein import 0.454608672807671 1.2885827940007024 0.1975431682919692 1.0 0.7503725187661342 25 Q9NPF5,Q14978,P06493,O00459 4 +Calcium ion import 0.5406563207008664 1.2878261444489576 0.1978064892046205 1.0 0.7503725187661342 12 O14936,O75844,Q8WWC4,Q9Y4W6 4 +Regulation of generation of precursor metabolites and energy 0.4542748674622409 1.2857551478103235 0.1985285280351945 1.0 0.7503725187661342 29 P06493,P49840 2 +Regulation of proteasomal protein catabolic process 0.3755002534293055 1.2857536369737126 0.1985290554805623 1.0 0.7503725187661342 63 P49840,P49841,Q96HY6,P53350,P24941 5 +Regulation of muscle adaptation 0.4987344248762284 1.284177798434488 0.1990797515629301 1.0 0.7503725187661342 16 P09874,P49840,P17252,Q12792 4 +Humoral immune response 0.5555236904080741 1.2819048439600982 0.199876028523144 1.0 0.7505653702554165 11 Q9UQ84 1 +Type b pancreatic cell development 0.9067485585685297 1.2810233881078212 0.2001854512672771 1.0 0.7508129219772115 3 P49840 1 +Macromolecule depalmitoylation 0.6397549703452974 1.2792600570479855 0.200805493294778 1.0 0.7521320057457783 6 Q9NUJ1 1 +Positive regulation of cell junction assembly 0.554908447769171 1.2787390307155793 0.200988970295036 1.0 0.7521320057457783 11 P49593,Q13464,P41440 3 +Kidney morphogenesis 0.7391523874688593 1.276751439887409 0.2016900144359281 1.0 0.7538016855321736 4 O75844 1 +Microtubule anchoring at microtubule organizing center 0.6694729346045682 1.2752996614268235 0.202203197539204 1.0 0.754270270263902 5 P49841 1 +Centriole assembly 0.6383518326230829 1.2731364867523771 0.2029696135344854 1.0 0.7550516880668778 6 P24941 1 +Lens development in camera type eye 0.6688438928804845 1.2726741430207835 0.2031336966833759 1.0 0.7552224872038716 5 Q99797,P35222,P08670,P28289 4 +Embryonic organ development 0.4332239850174507 1.2723238860810837 0.2032580651641335 1.0 0.7552455200371962 45 Q68CQ4,Q7Z6E9,Q8N1B4,O94788,P60953,Q9H6E4,Q03164,P00813,P54802,Q9Y6I3,P62995,P42892 12 +Amp metabolic process 0.4996014373454094 1.267358714192324 0.2050270551066195 1.0 0.7559892172289363 15 P11908,P55263,P30520 3 +Cellular response to oxygen levels 0.4491252150100183 1.26697176141528 0.2051653872242937 1.0 0.7559892172289363 34 P55786,P07237,O95831,Q99808,Q8N511 5 +I kappab phosphorylation 0.8858075040782958 1.2642717998410702 0.2061324877095267 1.0 0.7559892172289363 2 Q96HY6 1 +Negative regulation of cell population proliferation 0.3865438786740552 1.264015727994391 0.2062243818233269 1.0 0.7559892172289363 89 P07948,Q9Y3B8,Q96G23,O94788,Q9NR77,Q92796,O14936,Q96DY7,Q15392,Q32P28,P09601,P30536,P25054,Q9UII2,P50402,P98175,Q13162 17 +Regulation of dna damage response signal transduction by p53 class mediator 0.5519503747183236 1.2635150761893503 0.2064041320068104 1.0 0.7559892172289363 11 P14174 1 +Cellular response to reactive oxygen species 0.4508586377978779 1.262496108452282 0.2067703257262056 1.0 0.7559892172289363 30 Q99720,O95831 2 +Response to nutrient 0.4507759528590772 1.2618799552003102 0.2069919858115021 1.0 0.7563669418646713 30 P53985,P30536,O94788 3 +Positive regulation of mrna splicing via spliceosome 0.490453345808855 1.258899887713954 0.2080664944050476 1.0 0.7589244073208941 17 P19338,Q13595,P38159,P98179,P62995,Q14011,Q9Y2W1 7 +Positive regulation of cell division 0.5672006448395566 1.2562366405659036 0.2090301859211498 1.0 0.7601530158325891 10 Q96GD4,Q9H0H5 2 +Fatty acid derivative metabolic process 0.4800336042657507 1.2524455762587767 0.2104075477924247 1.0 0.7601530158325891 19 P33121,Q9UMR5,P35610 3 +Positive regulation of muscle hypertrophy 0.6037302056674198 1.2522667799105016 0.2104726695094689 1.0 0.7601530158325891 7 P09874,P17252,Q12792 3 +Negative regulation of inflammatory response to antigenic stimulus 0.7324047107352506 1.2503127929789497 0.2111853069674767 1.0 0.7614013221075696 4 P28070 1 +Protein complex oligomerization 0.3885897593199646 1.250149946812482 0.2112447771706445 1.0 0.7614013221075696 59 O94788,Q9H6R7,P38159,Q99720,P35637,P14174 6 +Protoporphyrinogen ix biosynthetic process 0.731029395915698 1.244925050282223 0.2131593018256354 1.0 0.7653376954874361 4 P50336 1 +Phosphatidylserine metabolic process 0.7301293855450524 1.2413995272612608 0.2144581936936296 1.0 0.7653649646738672 4 Q8NCC3 1 +Endoderm formation 0.6011151740433005 1.240288727757443 0.2148686202127292 1.0 0.7653649646738672 7 Q92541,Q8N7H5,P35222,P07942 4 +Endodermal cell differentiation 0.6011151740433005 1.240288727757443 0.2148686202127292 1.0 0.7653649646738672 7 Q92541,Q8N7H5,P35222,P07942 4 +Muscle adaptation 0.4873560443699882 1.239954071989294 0.2149923822357453 1.0 0.7653649646738672 17 Q12792,P09874,P49840,Q13464,P17252 5 +Positive regulation of lipopolysaccharide mediated signaling pathway 0.8796084828711176 1.2398674576972673 0.2150244222040205 1.0 0.7653649646738672 2 P14174 1 +Neural crest cell migration 0.7290146225979643 1.237033051468526 0.2160748124748426 1.0 0.7653649646738672 4 P08133,P98172 2 +Protein localization to cilium 0.497542083354095 1.2366422050801598 0.2162199438845045 1.0 0.7653649646738672 14 Q10713,Q9UPT5,P49841 3 +Very long chain fatty acid catabolic process 0.7285708845370407 1.2352950395932596 0.2167207191829199 1.0 0.7653649646738672 4 Q15067,P28288 2 +Smad protein signal transduction 0.5621165520231627 1.2310312251497952 0.2183111859783326 1.0 0.7653649646738672 10 Q96PK6,P09874,P08670 3 +Purine containing compound biosynthetic process 0.3650778800381595 1.2281860586208508 0.2193771309613055 1.0 0.7653649646738672 73 P00846,P30520,P35610,Q13126,P09874,P11908,P33121,P55263,Q9UMR5 9 +Xenobiotic metabolic process 0.529477790225343 1.228118237354409 0.2194025857938348 1.0 0.7653649646738672 12 P07099 1 +Negative regulation of canonical wnt signaling pathway 0.4887622968482225 1.2243338705791809 0.2208263046408149 1.0 0.7674284464162309 16 P49840 1 +Embryonic heart tube development 0.7251045209411768 1.2217201098347792 0.2218134888333076 1.0 0.76918611347459 4 P42892 1 +Leukotriene metabolic process 0.7248362912067202 1.220669828518725 0.2222110558124492 1.0 0.7695227657523936 4 Q14914 1 +Gmp salvage 0.7243142007798432 1.218625598967943 0.2229863284122086 1.0 0.7705186964459281 4 P55263 1 +Regulation of mrna polyadenylation 0.5112933164475764 1.2178451074372751 0.2232828392767734 1.0 0.7705186964459281 13 P09012,Q5VTR2,Q8N684,P18615,Q16630,Q09161 6 +Embryonic pattern specification 0.6253627430512732 1.216432115276818 0.2238203562417715 1.0 0.7712710831704768 6 P98172 1 +Intestinal absorption 0.5853970788337062 1.2163203556348563 0.2238629102302041 1.0 0.7712710831704768 8 Q8WTV0 1 +Dna replication independent chromatin organization 0.5738933548961204 1.2120605600107652 0.2254891995936017 1.0 0.7731539027819644 9 P46100 1 +Regeneration 0.4424466583918747 1.2101739872055617 0.2262121374910073 1.0 0.7731539027819644 33 P11908,P06493,P30536,Q96G23 4 +Response to alcohol 0.4417275026313878 1.210085511344 0.2262460821460874 1.0 0.7731539027819644 34 P09874,O95831,P30536,Q15126,Q9NPF5,P06493 6 +Kidney epithelium development 0.5578864631326101 1.2100541448890958 0.2262581170749413 1.0 0.7731539027819644 10 P35610 1 +Cellular response to nutrient 0.5940819865990355 1.2080651015638866 0.2270222220626951 1.0 0.7731539027819644 7 Q8TB36,Q15648,O15164,P09601 4 +Muscle cell migration 0.524537721737066 1.201720642716563 0.2294717805470645 1.0 0.7759545764424811 12 O15511,Q13464,Q13685,P31949 4 +Positive regulation of cell cell adhesion 0.4421275992394018 1.1998915227579632 0.2301814727208835 1.0 0.7770178515975692 31 P07948,P00813,P04439,P30825,P41440,P98172 6 +Dna methylation or demethylation 0.4600793224029871 1.1932154247214983 0.2327850152581421 1.0 0.7776942145921517 21 Q9NPF5,O75844,P09874,P46100 4 +Response to interferon alpha 0.6493570058605228 1.191342755240831 0.2335190557671027 1.0 0.7785186674009148 5 P12270,P10155,Q6L8Q7 3 +Negative regulation of cell projection organization 0.4410855252040586 1.1881684638613002 0.2347670454917554 1.0 0.7810495511388907 29 P35080,Q96G23,Q9NR77,Q8N5V2,Q9NQX7 5 +Glycosyl compound metabolic process 0.4408196960057821 1.1856491813817 0.2357608712407688 1.0 0.7821914341281168 28 Q13126,O60725,P11908,P55263,Q9NUJ1 5 +Nucleotide sugar metabolic process 0.4881608144091447 1.1823153696133846 0.2370805893281304 1.0 0.7821914341281168 14 Q86W56,P49840 2 +Mitochondrial rna catabolic process 0.6174511479208696 1.1818913841480234 0.2372488010824938 1.0 0.7821914341281168 6 Q6L8Q7 1 +Nucleoside monophosphate biosynthetic process 0.4523599613452306 1.181201318939834 0.2375227574531528 1.0 0.7821914341281168 22 P11908,P55263,P30520 3 +Regulation of mitophagy 0.5882049804930178 1.181134090365822 0.2375494591853564 1.0 0.7821914341281168 7 P27544 1 +B cell activation 0.4371380850515318 1.1809256203871048 0.2376322724237283 1.0 0.7821914341281168 35 P55327,P07948,P00813,P78318,Q9UQ84,P14174 6 +Cholesterol storage 0.8784192314087609 1.1796607693151944 0.2381351628596624 1.0 0.7821914341281168 3 Q8WTV0 1 +Amide transport 0.4309214014309385 1.177574181660843 0.238966407754638 1.0 0.7821914341281168 40 Q8N183,P53985,P08183,P41440 4 +Platelet degranulation 0.863621533442082 1.1771187475681364 0.2391481132675832 1.0 0.7821914341281168 2 O15439 1 +Negative regulation of smooth muscle cell migration 0.6447393531638923 1.1720805213888477 0.2411647294909427 1.0 0.7821914341281168 5 O94813,Q07954,Q14344 3 +Neuron death 0.3607258216025608 1.1716144054217064 0.2413519018449741 1.0 0.7821914341281168 64 Q9UMX5,P09874,Q15392,O95831,Q15233,P49841,Q99720,Q9NR28 8 +Regulation of protein export from nucleus 0.4756068451982207 1.168076415216145 0.242775942731358 1.0 0.7821914341281168 17 P12270,P50402,Q9Y3B8,P49841 4 +Protein homooligomerization 0.4310583142815596 1.1674385294294565 0.2430333190132636 1.0 0.7821914341281168 39 Q99720,P38159,P14174,O94788 4 +Mrna cleavage involved in mrna processing 0.5739919493768695 1.1629264854589323 0.2448593304990738 1.0 0.7821914341281168 8 Q8N684,P33240,Q6UN15,Q16630 4 +Negative regulation of epithelial cell proliferation 0.5010300683108524 1.1608232728472376 0.2457137765491219 1.0 0.7821914341281168 13 O14936,Q9Y3B8 2 +Trna pseudouridine synthesis 0.8593800978792787 1.1605242806458655 0.2458354139300596 1.0 0.7821914341281168 2 Q96PZ0 1 +Lymphocyte homeostasis 0.5730531182419751 1.158531491635208 0.2466472079958193 1.0 0.7838499782701547 8 P07948,P00813,P14174 3 +Regulation of carbohydrate metabolic process 0.4362536841076557 1.1557791243457758 0.2477715139603351 1.0 0.7844255895074274 31 O75844,P49840,P49841 3 +Regulation of protein localization to nucleus 0.4100113710078983 1.1516974652145322 0.2494454142502955 1.0 0.7857100258618229 49 Q14978,O00459,P09874,P49841,P53350,P06493 6 +Receptor clustering 0.4991272149872326 1.150254099373487 0.2500392300112868 1.0 0.7862626449460546 13 P49354,Q14696,Q92796,O43805,Q14168 5 +Mitochondrial fusion 0.4825188141368038 1.1496518381303962 0.2502872982952571 1.0 0.7862626449460546 14 Q9Y4W6,Q9Y6C9,Q8IWA4,Q99536,Q9GZY8 5 +Walking behavior 0.7064602176809888 1.1487927980169783 0.250641429793365 1.0 0.7862626449460546 4 O75844 1 +Deoxyribose phosphate metabolic process 0.5145780629262565 1.1485044607803887 0.2507603725769207 1.0 0.7862626449460546 12 P55263,P00813,P78549 3 +Gland development 0.3542239993891323 1.147891032446103 0.2510135506437145 1.0 0.7862626449460546 65 Q99808,O75844,P30536,O94788 4 +Negative regulation of developmental process 0.3815509368242665 1.1460714950595727 0.2517655708891597 1.0 0.7862626449460546 94 Q14004,Q96G23,P49840,P49841,Q99536,Q8N5V2,P30536,P14174,Q8N4Q0,Q96T37 10 +Endodermal cell fate commitment 0.6383420873253068 1.1454089011972932 0.2520398127933791 1.0 0.7862626449460546 5 Q92541,Q8N7H5,P35222 3 +Cell fate commitment involved in formation of primary germ layer 0.6383420873253068 1.1454089011972932 0.2520398127933791 1.0 0.7862626449460546 5 Q92541,Q8N7H5,P35222 3 +Negative regulation of metaphase anaphase transition of cell cycle 0.475595078648926 1.1453084922131092 0.2520813893748186 1.0 0.7862626449460546 16 P12270,Q96GD4,P53350,P49454 4 +Regulation of glucose import 0.5588660168613526 1.1401500601231735 0.2542237890876402 1.0 0.7864967410569 9 P49840 1 +Lymphocyte apoptotic process 0.4778556688838023 1.1392168187823626 0.2546127322910658 1.0 0.7864967410569 15 Q96GD4,P07948,P00813,P14174 4 +Mitochondrial depolarization 0.6368533367538007 1.139204891823845 0.2546177057184675 1.0 0.7864967410569 5 P09874,P30536 2 +Negative regulation of insulin secretion involved in cellular response to glucose stimulus 0.8531810766720955 1.1363168934025745 0.2558239631080119 1.0 0.7877348845898678 2 Q8N183 1 +Regulation of glucose transmembrane transport 0.5423076073713771 1.1327947436896313 0.2573004593252546 1.0 0.788356087412317 10 P49840 1 +Glycerolipid biosynthetic process 0.4290285120232929 1.1324078858850335 0.257462991011578 1.0 0.788356087412317 37 Q9NPH0,Q9NX62,Q96N66,O00459,Q10713,Q8NCC3,P33121,Q8WTV0 8 +Cellular response to molecule of bacterial origin 0.4333851848979448 1.1317491278228355 0.2577399208319468 1.0 0.788356087412317 27 P08670,P17252,O43823,P30536,P14174,Q8WTV0 6 +Regulation of neurotransmitter transport 0.4653395261908077 1.130233452603051 0.2583778672739298 1.0 0.788356087412317 18 P35080,Q4J6C6,P49841,P20339,P41440 5 +Iron ion transport 0.566922251600426 1.1298354230683836 0.258545578891791 1.0 0.788356087412317 8 Q9H9B4,O15173,Q15043,Q07960 4 +Positive regulation of release of cytochrome c from mitochondria 0.6052054320285554 1.1284566108187934 0.2591271312595213 1.0 0.788356087412317 6 Q96A26 1 +Bone growth 0.8638528478408607 1.1277801251369373 0.2594127890074984 1.0 0.788356087412317 3 O75844 1 +Growth plate cartilage development 0.8638528478408607 1.1277801251369373 0.2594127890074984 1.0 0.788356087412317 3 O75844 1 +Negative regulation of dna templated transcription elongation 0.5764749771452333 1.1273916614310522 0.2595769230489622 1.0 0.788356087412317 7 Q9H3P2 1 +Positive regulation of proteolysis involved in cellular protein catabolic process 0.4299707027341958 1.1253617785311676 0.2604357606269345 1.0 0.788356087412317 35 P53350,Q96HY6,P49840,P49841 4 +Regulation of endothelial cell migration 0.4318344295867337 1.1204394741260093 0.2625265314196501 1.0 0.788356087412317 27 Q13685,P06576,P42785,P17252,Q8WTV0 5 +Negative regulation of small molecule metabolic process 0.4672078470604667 1.1167236800032774 0.26411248972884 1.0 0.788356087412317 17 P49840,O14874 2 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.4930740403153899 1.1166457408898678 0.2641458259390767 1.0 0.788356087412317 13 P61604,Q96A26,Q9NR28,O95831 4 +Positive regulation of nucleobase containing compound transport 0.69815669918219 1.1163825748195022 0.2642584090817736 1.0 0.788356087412317 4 Q9H7Z3 1 +Positive regulation of rna export from nucleus 0.69815669918219 1.1163825748195022 0.2642584090817736 1.0 0.788356087412317 4 Q9H7Z3 1 +Taurine transport 0.847960848287105 1.1159775932606213 0.2644317258917794 1.0 0.788356087412317 2 Q8TDW0 1 +Endoplasmic reticulum calcium ion homeostasis 0.6972441903711545 1.1128242678759277 0.2657839106235733 1.0 0.788356087412317 4 Q9UM00,P16615 2 +Lipid biosynthetic process 0.4161440921868707 1.1123145496018882 0.26600293027855 1.0 0.788356087412317 131 Q9NX62,O94788,O00459,P37268,Q8NBX0,P33121,Q9UBM7,Q9H4L5,Q8WTV0,Q9NPH0,Q06136,Q8NCC3,Q8IVS2,Q16850,O95864,O14975,Q14739,P14174,Q9H7Z7,Q96G23,Q9BY49,P48651,Q15392,P27544,P30536,P28288,P35610,Q96N66,Q10713,Q15126 30 +Regulation of mrna processing 0.3684582089850294 1.110573598605031 0.2667519321671165 1.0 0.788356087412317 85 Q92841,P17844,P18615,P98179,P21127,P98175,Q5VTR2,Q08170,P51116,Q13595,Q16630,P31483,Q8N7H5,Q96T37,P09012,Q16629,P19338,P84103,Q96PU8,Q8IY67,Q96E39,P22626,Q14011,Q13242,P61978,Q9BWF3,O75525,Q8N684,O75494,P38159,Q92879,P09651,P62995,Q9Y2W1 34 +Activation of innate immune response 0.4574986661030814 1.1089319947478102 0.2674595201952265 1.0 0.788356087412317 19 Q8WXF1,Q9NUD5,P07948,Q15233,Q96PK6 5 +Positive regulation of autophagy of mitochondrion 0.5723374990032276 1.1084450324544783 0.2676696657131394 1.0 0.788356087412317 7 P27544 1 +Mismatch repair 0.5364809431488076 1.103915554656486 0.2696297707735775 1.0 0.788356087412317 10 Q9UQ84 1 +Steroid biosynthetic process 0.4169179187364072 1.101712042016648 0.2705868800531976 1.0 0.788356087412317 43 P37268,Q15392,Q16850,P28288,Q14739,Q9UBM7,Q9H4L5,P30536,Q15126 9 +Positive regulation of cell adhesion 0.3625345446603736 1.1008891554419018 0.2709449024412469 1.0 0.788356087412317 62 Q96EY1,P07948,Q14185,P60953,P07237,P00813,Q13464,P04439,P49841,P17252,P30825,P41440,P98172 13 +Purine nucleoside metabolic process 0.5505230522806819 1.100246411481353 0.2712247738876714 1.0 0.788356087412317 9 P55263,Q13126,O60725 3 +Regulation of nucleocytoplasmic transport 0.4017054190235016 1.099895559495858 0.2713776296890995 1.0 0.788356087412317 50 Q14978,Q9Y3B8,O00459,P12270,Q9H7Z3,P49841,Q9NPF5,P06493,P50402 9 +Positive regulation of dna recombination 0.428996899971119 1.0997522570286022 0.2714400792924478 1.0 0.788356087412317 27 Q9NV56,P09874,Q7Z4V5,P35637,Q9UBU8 5 +Aspartate transmembrane transport 0.6937549749315226 1.0992250484263268 0.2716699155889119 1.0 0.788356087412317 4 Q8TDW0 1 +Phosphatidylinositol acyl chain remodeling 0.8553006964643882 1.0974219066674742 0.2724570014082386 1.0 0.788356087412317 3 Q96N66 1 +Response to inorganic substance 0.386780525158263 1.0969103973878376 0.2726805631430333 1.0 0.788356087412317 103 O60888,P03915,P30520,O95831,Q8TAD4,Q99720,P30536,P06493,P24941,P46100 10 +Gdp metabolic process 0.6928541474358835 1.0957159259105096 0.2732031109484638 1.0 0.788356087412317 4 O14936,Q14168 2 +Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.5594967420478291 1.095097993327599 0.273473707726604 1.0 0.788356087412317 8 P14174 1 +Embryonic digestive tract development 0.8537859007833074 1.0920536307774291 0.2748095289225303 1.0 0.788356087412317 3 P00813,O94788 2 +Very long chain fatty acid metabolic process 0.5339195018496342 1.091226097118988 0.2751734072832064 1.0 0.788356087412317 10 P33121,Q15067,P28288 3 +Positive regulation of histone h3 k4 methylation 0.5030297247783715 1.0868534056652197 0.2771016010996212 1.0 0.7910381286458126 12 Q92541,Q03164,P61964,P35222,P18615,Q9H3P2 6 +Modification of postsynaptic actin cytoskeleton 0.6905510578962205 1.086748014855748 0.2771481878507966 1.0 0.7910381286458126 4 P35080 1 +Response to reactive oxygen species 0.4249221642498046 1.0862569573918113 0.2773653243052831 1.0 0.7910381286458126 35 Q99720,O95831,P06493 3 +Positive regulation of cytokinesis 0.5475909350837819 1.086230546146609 0.2773770061485316 1.0 0.7910381286458126 9 Q96GD4 1 +Deoxyribonucleoside triphosphate metabolic process 0.5574191714458678 1.0853841299570122 0.2777515583015026 1.0 0.7917529924642746 8 P55263,P00813 2 +Regulation of small molecule metabolic process 0.4130865362528563 1.084476814874002 0.278153441449017 1.0 0.7920608264160542 44 P34913,O14874,P49840,P49841,O75844 5 +Detection of external biotic stimulus 0.8500640267670158 1.0788758855333005 0.2806430600936118 1.0 0.7939751204330558 3 Q8WTV0 1 +Organ growth 0.4567343394338002 1.0766144566227132 0.2816525430038576 1.0 0.7947615383361315 18 P49840,P08133,P06493,P80723,O75844 5 +Response to ketone 0.4228559651976311 1.0764889949245404 0.2817086200941521 1.0 0.7947615383361315 36 Q13126,P30536,O95831 3 +Nucleobase containing small molecule catabolic process 0.621410007831591 1.07493858243154 0.2824022266549999 1.0 0.7949208710077448 5 Q13126,P49840 2 +Biomineralization 0.5148649882857763 1.072599373500123 0.2834509059749146 1.0 0.7951125798795698 11 Q6P4Q7,O75844 2 +Cyclic gmp amp transmembrane import across plasma membrane 0.8482375979112448 1.0724157451782643 0.2835333389994585 1.0 0.7951125798795698 3 Q8TDW0,P41440 2 +Regulation of protein deacetylation 0.5432717250971746 1.0655948862516416 0.2866068118620619 1.0 0.79799974420174 9 P49354 1 +Regionalization 0.4505865303308081 1.064984391904602 0.2868829929250194 1.0 0.79799974420174 19 P80723,P17252,Q12849,O94788 4 +Sphingolipid metabolic process 0.4241094477052787 1.0629660565532129 0.2877973447242259 1.0 0.79865950070887 28 Q06136,Q8NCC3,Q96G23 3 +Regulation of mitotic sister chromatid segregation 0.4540538354770422 1.0599320766804174 0.2891755014253192 1.0 0.8007455067630915 18 P12270,Q96GD4,P53350,P49454 4 +Epithelial cell development 0.4147034857125136 1.0573199877372057 0.2903655741354787 1.0 0.8024835590046454 41 P49840,P46100,P49841 3 +Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway 0.8438976900645903 1.0570834671372726 0.2904734958618813 1.0 0.8024835590046454 3 P49840 1 +Response to osmotic stress 0.4446086431938257 1.0566264118255493 0.2906821215922006 1.0 0.8024835590046454 20 Q14978,P08183,P30536 3 +Regulation of steroid metabolic process 0.4657490696240443 1.0527194646072735 0.2924695849959549 1.0 0.8040533661804696 14 P34913,P30536,Q9UBM7 3 +Positive regulation of chemokine production 0.5875066608614701 1.0513748485449883 0.2930864627294074 1.0 0.8040533661804696 6 P14174 1 +Dna replication initiation 0.4273740996734737 1.0511514452249264 0.2931890393762915 1.0 0.8040533661804696 23 P24941,Q9Y619 2 +Actin filament based transport 0.5500800681673457 1.0510946023994814 0.2932151428618708 1.0 0.8040533661804696 8 O43707,Q9Y4I1,Q9UH99,Q8WXH0 4 +Pseudopodium organization 0.8309951060358876 1.0502061065122592 0.2936233625928663 1.0 0.8040533661804696 2 P25054 1 +Positive regulation of pseudopodium assembly 0.8309951060358876 1.0502061065122592 0.2936233625928663 1.0 0.8040533661804696 2 P25054 1 +Positive regulation of peptidyl tyrosine phosphorylation 0.4624205651009942 1.0484336096093028 0.2944388753697273 1.0 0.8040533661804696 15 P14174,Q92796 2 +Negative regulation of inflammatory response 0.4802142191074813 1.0453581856883092 0.2958574547397223 1.0 0.8040533661804696 13 P00813,P28070 2 +Regulation of dna recombination 0.392942704161569 1.043808193900612 0.2965741398360428 1.0 0.8040533661804696 51 P10412,Q6NSI4,O95619,Q9NV56,Q92878,P07305,P09874,Q7Z4V5,Q9NYB0,P49959,P16402,P20585,P16403,P35637,Q9UBU8,Q9NPF5,Q9NY27 17 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.4792672441023367 1.0401172350721262 0.2982854372701538 1.0 0.8040533661804696 13 Q8IXB1,O95831 2 +Deoxyribonucleoside monophosphate metabolic process 0.5572191919985009 1.0393037847066733 0.2986634752206125 1.0 0.8040533661804696 7 P55263 1 +Positive regulation of membrane depolarization 0.6783104054416798 1.0391832734392947 0.2987195080828797 1.0 0.8040533661804696 4 P30536 1 +Ephrin receptor signaling pathway 0.5569639890941377 1.0381382865708662 0.2992056789503188 1.0 0.8040533661804696 7 Q8N5V2,P98172 2 +Antigen processing and presentation of peptide antigen via mhc class i 0.5080679817930697 1.0376880993178257 0.2994152872111522 1.0 0.8040533661804696 11 P30101,P04439 2 +Negative regulation of reproductive process 0.6123059096417605 1.0371550783373311 0.299663589685643 1.0 0.8040533661804696 5 P00813 1 +Positive regulation of mitotic cell cycle phase transition 0.4201263494093795 1.0369961639786471 0.2997376449150315 1.0 0.8040533661804696 32 P06493 1 +Antigen processing and presentation of peptide antigen 0.4931328672059868 1.0341179289677027 0.3010810355422944 1.0 0.8040533661804696 12 P30101,P04439 2 +Deoxyribose phosphate catabolic process 0.5559243480881233 1.0333909909046692 0.3014209608076852 1.0 0.8040533661804696 7 P00813,P78549 2 +Negative regulation of gene expression epigenetic 0.4200474960949866 1.033207040430929 0.301507018832551 1.0 0.8040533661804696 28 O75151,P12270,Q9H7Z3,P07305,Q8NEY8,P24941 6 +Import across plasma membrane 0.4453722804066242 1.0318825820715176 0.302127126504915 1.0 0.8040533661804696 19 P33121,P30825,P41440 3 +Regulation of fatty acid transport 0.8366252305675776 1.0314516997160648 0.3023290472357371 1.0 0.8040533661804696 3 P14174 1 +Pyrimidine nucleotide catabolic process 0.8363281743615281 1.0304064316867028 0.3028192552892041 1.0 0.8040533661804696 3 P78549 1 +Regulation of protein targeting 0.4301144081207066 1.0298816602936454 0.3030655608780979 1.0 0.8040533661804696 22 P49840 1 +Protein lipid complex assembly 0.6105235230262708 1.0297691727906064 0.3031183751040052 1.0 0.8040533661804696 5 P35610 1 +Dna modification 0.4189302547829743 1.0264670240381315 0.304671499520817 1.0 0.8040533661804696 27 P09874,Q9NPF5,O75844,P46100,P78549 5 +Leukocyte homeostasis 0.4916921831186388 1.0264521394976271 0.3046785122162181 1.0 0.8040533661804696 12 P07948,P00813,P14174 3 +Vitamin metabolic process 0.4184616976283125 1.0253574053926655 0.3051945784592225 1.0 0.8040533661804696 26 O94788 1 +Pattern specification process 0.4189165779785783 1.024341143615778 0.3056741710053416 1.0 0.8040533661804696 29 O75569,O94788,P17252,P62995,Q12849,P25054,P29372,P98172,P80723 9 +Regulation of mitotic cell cycle phase transition 0.3550048710896568 1.0223793909314551 0.3066013708420889 1.0 0.8041854931807045 80 Q96GD4,Q9Y619,P49454,Q96DY7,Q6IQ49,Q96K76,P53350,P06493,P24941,Q68E01 10 +Response to ethanol 0.4904775011085345 1.019991426414911 0.3077325269051849 1.0 0.8053724251671084 12 P06493 1 +Glycerolipid catabolic process 0.5529884509805544 1.0199911351601478 0.3077326650380345 1.0 0.8053724251671084 7 Q8WTV0 1 +Intrinsic apoptotic signaling pathway by p53 class mediator 0.4541636450969797 1.016995947879949 0.3091553570711336 1.0 0.8075450449391404 16 P61978,P14174 2 +Pigment metabolic process 0.4176156966425778 1.0169134472407069 0.3091946056902013 1.0 0.8075450449391404 27 P50336,P36551,P00813,P22830,P34897,P30519,P30536 7 +Long chain fatty acid metabolic process 0.4220567776478299 1.0141795679408174 0.3104970762507075 1.0 0.8100165501768268 23 P07099,O95864,P23786,P33121,P28288,Q9H7Z7 6 +Pigment biosynthetic process 0.4275963194283532 1.0128036952164337 0.311153935342457 1.0 0.8102532328151427 22 P50336,P36551,P00813,P22830,P34897,P30536 6 +Cellular response to potassium ion 0.6713820252307308 1.0123462136972148 0.3113725457352512 1.0 0.8102532328151427 4 Q14168 1 +Response to potassium ion 0.6713820252307308 1.0123462136972148 0.3113725457352512 1.0 0.8102532328151427 4 Q14168 1 +Response to cold 0.5029582631480953 1.0114817696985507 0.3117859021493594 1.0 0.8105941619433865 11 Q13217,P17252,Q14011 3 +Heterochromatin organization 0.4170332659563298 1.010465164225848 0.3122724811923589 1.0 0.8105941619433865 29 O75151,P12270,Q9H7Z3,P07305,Q8NEY8,P24941 6 +Positive regulation of mrna 3 end processing 0.6055556298403395 1.0092052448805968 0.3128762117879704 1.0 0.8105941619433865 5 Q9H2U1,Q8N7H5 2 +Long chain fatty acid import across plasma membrane 0.8202283849918331 1.0087701700139295 0.3130848702316082 1.0 0.8105941619433865 2 P33121 1 +Neural crest formation 0.605323084519318 1.00824349796046 0.313337580512024 1.0 0.8105941619433865 5 Q14978 1 +Steroid esterification 0.8297954833819665 1.0074554472438295 0.3137159574227097 1.0 0.8105941619433865 3 P35610 1 +Regulation of inflammatory response to antigenic stimulus 0.5772582233508887 1.006876920592798 0.3139939241446607 1.0 0.8105941619433865 6 P28070 1 +Odontogenesis 0.5500531451843829 1.0066039994629188 0.3141251117397443 1.0 0.8105941619433865 7 Q6P4Q7 1 +Carbohydrate derivative catabolic process 0.4138269846259061 1.0061075365135534 0.3143638437289588 1.0 0.8105941619433865 36 Q8TCJ2,P35610,Q13126,P49840,P00813,P54802,Q9H773,Q9NUJ1,P78549 9 +Zymogen activation 0.5770725445796764 1.0060719308693469 0.3143809698448176 1.0 0.8105941619433865 6 Q15392 1 +Positive regulation of lipid localization 0.4571956997996639 1.0034395530289852 0.3156488282210976 1.0 0.8120186200219779 14 Q8WTV0,P14174 2 +Export across plasma membrane 0.5155981959325272 1.000639493052693 0.3170011296225952 1.0 0.8139667427097019 10 P08183 1 +Import into cell 0.4154310046042556 0.9994352447422594 0.3175838935168928 1.0 0.8141510884342007 28 Q99808,P33121,P30825,P41440 4 +Positive regulation of cellular protein catabolic process 0.4059884866510754 0.9978324512029876 0.3183606114109714 1.0 0.8154880430972016 42 P53350,Q96HY6,P49840,P49841 4 +Neutral lipid metabolic process 0.4859434604830256 0.995897856331497 0.3192997769849559 1.0 0.8175278899878045 12 Q8NCC3,Q8WTV0,P33121 3 +Positive regulation of necrotic cell death 0.574315378706987 0.9941242410511396 0.3201623850434376 1.0 0.8177950797525472 6 P30536 1 +Response to mineralocorticoid 0.5377945719015844 0.9938145420177272 0.3203131650761266 1.0 0.8177950797525472 8 O95831 1 +Ceramide biosynthetic process 0.4988123373760716 0.99024811697 0.3220528591296725 1.0 0.8193629867427297 11 P27544,Q96G23 2 +Serine transport 0.6639280140738673 0.983554259544279 0.3253347243477531 1.0 0.8219309395751475 4 Q15758,Q96NB2 2 +Hypotonic response 0.8133768352365289 0.982543117524442 0.3258323519286219 1.0 0.8219309395751475 2 P30536 1 +Cellular hypotonic response 0.8133768352365289 0.982543117524442 0.3258323519286219 1.0 0.8219309395751475 2 P30536 1 +Regulation of gene expression epigenetic 0.4053537622209516 0.9810786223171748 0.3265539716118968 1.0 0.8219309395751475 41 O75151,P12270,Q9H7Z3,P07305,Q8NEY8,Q8NB78,O14497,P24941,Q96T37,P84243 10 +Negative regulation of cell aging 0.6630808987983041 0.9802879906028804 0.326943981088122 1.0 0.8219309395751475 4 P14174 1 +Response to wounding 0.3454855461528135 0.9793217201759692 0.3274210417271033 1.0 0.8219309395751475 75 Q96G23,P42785,P08133,Q9UNN8,P30536,P06493,Q8WTV0,Q16625 8 +Regulation of leukocyte apoptotic process 0.4827108760746971 0.978743914102808 0.3277065281056457 1.0 0.8219309395751475 12 Q96GD4,P14174 2 +Regulation of tor signaling 0.482523145596034 0.9777483700811151 0.3281987921418685 1.0 0.8219635881353077 12 P49840 1 +Regulation of lipoprotein particle clearance 0.5704724446008712 0.9774904050734484 0.3283264256271441 1.0 0.8219635881353077 6 P61978 1 +Carbohydrate transmembrane transport 0.4670251241128066 0.9725140925692862 0.3307948574501922 1.0 0.825091568109343 13 P49840 1 +Histone h3 k4 trimethylation 0.509538505322855 0.9707768932834936 0.3316593914626904 1.0 0.8254031039088997 10 Q03164,P16403,P10412,Q6UXN9 4 +Insulin receptor signaling pathway 0.4115933611064571 0.9704458708681613 0.3318242934881925 1.0 0.8254920434733508 29 P49840,P49841 2 +Phospholipid catabolic process 0.4945162649603995 0.9682779851940438 0.3329055563890568 1.0 0.8275376938477099 11 Q8WTV0 1 +Regulation of low density lipoprotein particle clearance 0.594396339525801 0.9631489120681118 0.3354727987376364 1.0 0.8306139775459619 5 P61978 1 +Glucose import 0.4796785041378971 0.9626725579614712 0.3357118723734307 1.0 0.8306139775459619 12 P49840 1 +Regulation of entry of bacterium into host cell 0.8159268929503979 0.9589800843845464 0.3375687782094632 1.0 0.8307843983073228 3 Q96KP1,Q9UPT5 2 +Entry of bacterium into host cell 0.8159268929503979 0.9589800843845464 0.3375687782094632 1.0 0.8307843983073228 3 Q96KP1,Q9UPT5 2 +Mrna cleavage 0.5071317246102934 0.958934116587376 0.3375919364429824 1.0 0.8307843983073228 10 Q8N684,P33240,Q6UN15,Q16630 4 +Cellular response to vitamin 0.5660435988854335 0.9583501837923788 0.3378862062799705 1.0 0.830817452932094 6 Q8TB36,Q15648,O15164 3 +Positive regulation of cellular amide metabolic process 0.3410787611948841 0.9549450772323044 0.3396054723498107 1.0 0.8310515052425503 64 Q13217,Q6P087,P08670,Q567V2,P49840,P67809,Q14011 7 +Negative regulation of atp metabolic process 0.529361791703614 0.9546169431425128 0.3397714457595837 1.0 0.8310515052425503 8 P30536 1 +Positive regulation of cell matrix adhesion 0.4913372685523103 0.9520445187831328 0.3410744045431233 1.0 0.8310515052425503 11 P46939,P49593,Q13464,P49841 4 +Coenzyme a biosynthetic process 0.5911608645176649 0.9498357433803938 0.3421957208923638 1.0 0.8310515052425503 5 P35610 1 +Cytokine production involved in immune response 0.505258146466356 0.9497228238619037 0.3422531093756003 1.0 0.8310515052425503 10 P04439,P14174 2 +Protein destabilization 0.490418343964387 0.9473561575828748 0.343457323737895 1.0 0.8310515052425503 11 P53350 1 +Cellular response to vitamin d 0.5904673719343456 0.9469847841321134 0.3436465324794888 1.0 0.8310515052425503 5 Q8TB36,Q15648,O15164 3 +Antigen processing and presentation of endogenous peptide antigen 0.5365399032356958 0.9451313025203149 0.3445918461731745 1.0 0.8310515052425503 7 P04439 1 +Antigen processing and presentation of endogenous antigen 0.5365399032356958 0.9451313025203149 0.3445918461731745 1.0 0.8310515052425503 7 P04439 1 +Negative regulation of mitochondrion organization 0.4463164084355878 0.9410082516850202 0.3467006305359912 1.0 0.8319285008005072 14 P30536 1 +Neuromuscular junction development 0.5260972364866147 0.939475212355674 0.3474868130034476 1.0 0.8319285008005072 8 P49354,Q9Y4W6,Q14696 3 +Regulation of intracellular estrogen receptor signaling pathway 0.443699763831854 0.9389142005049974 0.3477747976957559 1.0 0.8319285008005072 15 Q96HY6 1 +Positive regulation of b cell activation 0.4885801765642708 0.9379836402160492 0.3482528175754584 1.0 0.8326538560137504 11 P14174 1 +Peptidyl asparagine modification 0.5249443344186749 0.9341326598167816 0.3502354667270602 1.0 0.8355188009901612 8 Q8TCJ2,Q9H0U3,P04844,P39656,Q9NYU2,P46977 6 +Purine deoxyribonucleotide metabolic process 0.6507128391680322 0.9327509688268492 0.3509485621252715 1.0 0.8365315922106094 4 P55263 1 +Positive regulation of cytokine production involved in immune response 0.5152589908425884 0.9322824562593373 0.3511905718385568 1.0 0.8365482462244566 9 P14174 1 +Cellular response to lipid 0.3656155731872096 0.9319779672833416 0.3513479120108389 1.0 0.8366112167143337 97 O94788,P49841,O95831,Q96HY6,P30536,P14174,Q8WTV0 7 +Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.7993474714518696 0.9292272981786592 0.3527713031745247 1.0 0.838538298043843 2 Q92783 1 +Signal transduction by p53 class mediator 0.3960949516179379 0.9285575576740808 0.3531184259038482 1.0 0.838538298043843 43 P61978,Q96GD4,P14174,O75844,P46100 5 +Telomere organization 0.3423646433777226 0.9263295937318674 0.3542747209447543 1.0 0.8397241877073287 63 Q96GD4,P46100,Q9UQ84,P41440 4 +Regulation of mitochondrial rna catabolic process 0.5852384062704277 0.9255195512784052 0.3546957185495922 1.0 0.8397241877073287 5 Q8IYB8,Q8TCS8,Q12849,P42704 4 +Telomere maintenance 0.3496864373521396 0.9251044113619978 0.3549115986421105 1.0 0.8397241877073287 61 Q96GD4,P46100,Q9UQ84,P41440 4 +Cell migration involved in sprouting angiogenesis 0.558188714488566 0.9244917292110932 0.3552303556867722 1.0 0.8397241877073287 6 O00443,P09601,O94813 3 +Mrna 3 splice site recognition 0.648057460006529 0.9225849997817168 0.3562235156901843 1.0 0.8410138488274724 4 Q15459,Q15637,Q15428 3 +Morphogenesis of embryonic epithelium 0.4191021528000963 0.9215449627854352 0.3567659778278185 1.0 0.8419835170965981 21 P25440,P17252,O94788 3 +Negative regulation of amyloid precursor protein biosynthetic process 0.7970636215334282 0.920601569584661 0.3572584824395872 1.0 0.8421792952122871 2 Q9NQX7 1 +Negative regulation of protein binding 0.4035092546776837 0.917749689155795 0.3587499271466989 1.0 0.8431287736789468 26 Q96GD4,P49841 2 +Fatty acid metabolic process 0.3606599057653003 0.9126064318766652 0.3614495703510072 1.0 0.8447674076090992 94 P07099,P35610,Q9BY49,Q8NCC3,Q8IVS2,Q15067,Q9BWD1,P23786,P33121,P28288,Q8N8N7,P14174,Q8N4Q0,Q14914,O95864,P42126,O15254,Q9H7Z7 18 +Muscle tissue development 0.383077377259558 0.912248151438818 0.3616381014341996 1.0 0.8447674076090992 49 O94788,P49454,P49840,O75446,P41440,P06493,Q8NEZ5,O75844 8 +Base excision repair ap site formation 0.7947797716149979 0.9119918612329228 0.3617730019535523 1.0 0.8447674076090992 2 P78549 1 +Viral gene expression 0.4027979197464678 0.911781089269551 0.3618839671916429 1.0 0.8447674076090992 34 P49840 1 +Modulation of excitatory postsynaptic potential 0.6450861381244848 0.9112278070447728 0.3621753554762841 1.0 0.8447674076090992 4 Q13614,Q9UQB8 2 +Intracellular receptor signaling pathway 0.3647172028908316 0.91037022379077 0.3626272955010388 1.0 0.8451268903419402 56 P09874,P42785,Q96HY6,O94788 4 +Cellular response to interferon alpha 0.8018929503916497 0.9103203448858568 0.362653592177085 1.0 0.8451268903419402 3 P12270,Q6L8Q7 2 +Entry into host 0.4031755911674863 0.9081816207239084 0.363782272850212 1.0 0.8463532966092847 30 P07237,O15118,Q12899,Q96KP1,Q9UPT5,Q15758,P06493,Q8WTV0 8 +Leukocyte proliferation 0.4001067576086986 0.9053557647212526 0.3652769424600346 1.0 0.8466320148167995 37 P07948,P00813,P04439,Q00577,P30825,P14174,P98172 7 +Alternative mrna splicing via spliceosome 0.395959252763898 0.9048298387087236 0.3655555412443161 1.0 0.8466320148167995 41 Q92841,P17844,Q9Y2W1,Q96I25,P98175,Q14004,P51116,P31483,Q96T37,P23246,O60828,Q8IY67,Q13242,Q9BWF3,O75525,P38159,P09651,Q92879,P62995,Q07955 20 +Forebrain regionalization 0.7921696574225094 0.9021723057384524 0.3669653439043938 1.0 0.8471337401925918 2 P62995 1 +Histone lysine demethylation 0.5180137059660551 0.9020746899723304 0.3670171928325836 1.0 0.8471337401925918 8 Q8NB78 1 +Endothelial cell proliferation 0.4245725566219651 0.9005461648806415 0.3678296692937253 1.0 0.8475239733704388 19 O94788 1 +Mitophagy 0.439200285240405 0.900369948511542 0.3679234077853246 1.0 0.8475239733704388 14 P21796,P27544 2 +Positive regulation of cell cycle 0.3447847602880669 0.8948251796195048 0.3708805479663006 1.0 0.8501784727591921 81 Q96GD4,Q96DY7,Q96HY6,P06493,P46100 5 +Regulation of calcium ion import 0.7970041649477595 0.8934743411020072 0.371603207018941 1.0 0.8511666927397538 3 O14936 1 +Regulation of establishment of planar polarity 0.6404234639390405 0.8934468385330923 0.3716179291540356 1.0 0.8511666927397538 4 Q8TAA9,P60953 2 +Protein o linked mannosylation 0.6401170918328722 0.8922803187140129 0.3722427006849487 1.0 0.8520784742397949 4 O60762,Q8NAT1 2 +Smooth muscle cell migration 0.4929541409676191 0.889427901165223 0.373773155494284 1.0 0.8542366612331812 10 Q13685,O15511,O94813,Q14344,P31949,Q07954 6 +Sulfur amino acid metabolic process 0.478578477496511 0.8871387428230065 0.3750042076133231 1.0 0.8542366612331812 11 Q13126 1 +Macromolecule deacylation 0.3994204862641898 0.8861409635998178 0.3755415715336272 1.0 0.8544380063391515 34 P49354,Q96PK6,O43823,Q9UBU8,Q9NUJ1,Q9UMR5 6 +Purine nucleoside monophosphate metabolic process 0.4032413216803558 0.8840728440715411 0.3766568914085382 1.0 0.8547415224372588 23 P30520,O14936,P00813,P11908,P55263 5 +Protein autoprocessing 0.6379216232811669 0.8839278045894744 0.3767351866130395 1.0 0.8547415224372588 4 P09874 1 +Organic hydroxy compound metabolic process 0.3683491426655976 0.8807806648167439 0.3784365468830015 1.0 0.8552149284417979 104 Q9NX62,O94788,P37268,P30837,Q14914,Q9UBM7,Q9H4L5,Q9BW91,Q8WTV0,O15118,Q16850,Q14739,Q9BY49,Q15392,P28288,P48735,P34913,P35610,Q10713,Q15126,Q9UHB6 21 +Clathrin dependent endocytosis 0.4336695155913194 0.8806745351627948 0.3784940034664248 1.0 0.8552149284417979 15 P53680,Q5VW38,O14976 3 +Chromatin assembly or disassembly 0.341208120435487 0.8799684396671371 0.3788764069050645 1.0 0.8552149284417979 79 Q9BW71,O75151,P10412,Q01105,P84243,P12270,Q9H7Z3,P07305,Q8NEY8,P25440,P16403,O14497,P24941,Q12873,P46100,Q969G3 16 +Autophagosome membrane docking 0.6367252011581608 0.8793811976642921 0.3791946233374568 1.0 0.8552149284417979 4 P56962,O95721 2 +Pore complex assembly 0.4499953577140178 0.8791149183639756 0.3793389697180589 1.0 0.8552149284417979 13 Q8WYP5,Q9BTX1 2 +Neurotransmitter transport 0.3989203571490859 0.8769466200328023 0.3805156324842189 1.0 0.8565004860354787 31 P35080,Q4J6C6,P49841,Q99808,P20339,P41440 6 +Negative regulation of nervous system development 0.4347401957085329 0.8749968061874842 0.381575643492767 1.0 0.8575018323073441 14 Q96G23 1 +Regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.5026026065910204 0.8725231148595346 0.3829230637618432 1.0 0.8583398627028774 9 P14174 1 +Cell cycle g1 s phase transition 0.3783156117679686 0.8702733748967351 0.3841510256376237 1.0 0.8590305125437555 49 Q96DY7,P24941,Q96HY6,Q8N6R0 4 +Regulation of anion transport 0.473578665401879 0.8618318931273352 0.3887800317433689 1.0 0.8626008203788371 11 P08183 1 +Regulation of protein localization to cilium 0.7866366033935753 0.8579478012012025 0.3909212874312178 1.0 0.8642392610269739 3 P49841 1 +Regulation of mitochondrial fusion 0.6308716231588052 0.8571906826008575 0.3913395109616542 1.0 0.8642392610269739 4 Q99536 1 +Negative regulation of sprouting angiogenesis 0.7800978792822095 0.8570525743529006 0.391415829638289 1.0 0.8642392610269739 2 Q9Y6I3 1 +Histone h3 k27 trimethylation 0.7862271540470074 0.8565505770645311 0.3916933096477235 1.0 0.8642392610269739 3 P16403,P10412 2 +Regulation of mitotic nuclear division 0.3950516190467469 0.8564404341079204 0.3917542073533318 1.0 0.8642392610269739 35 P53350,Q96GD4,Q96DY7,Q14004 4 +Positive regulation of stem cell differentiation 0.6303956208128311 0.8553902707109405 0.3923351279826419 1.0 0.8645699971941921 4 Q9H2U1,Q9Y6C9 2 +Negative regulation of dna biosynthetic process 0.4590425212322701 0.853971193142647 0.3931209508344886 1.0 0.8645699971941921 12 P09651,P27544,Q99543 3 +Tor signaling 0.426404369792801 0.852446035896858 0.3939665783272574 1.0 0.8645699971941921 16 P49840 1 +Golgi organization 0.3586386470954139 0.8517483882945831 0.3943537576375613 1.0 0.8645699971941921 56 Q5VU43,Q9Y2V7,Q14789,Q96CV9,P60953,P56962,Q9Y4I1,Q969M3,Q8NHH9,Q8TBA6,O14976,P06493,O15260,P49755 14 +Digestive system process 0.4715700593873114 0.8516886947007821 0.3943868969782964 1.0 0.8645699971941921 11 Q8WTV0 1 +Vesicle targeting to from or within golgi 0.458454973377653 0.8508970132802173 0.3948265641191961 1.0 0.8645699971941921 12 Q8N6H7 1 +Regulation of lipopolysaccharide mediated signaling pathway 0.7845566009483267 0.8508546911797087 0.3948500764079377 1.0 0.8645699971941921 3 P14174 1 +Regulation of nuclear division 0.3937605304119914 0.8508253061048092 0.3948664019549894 1.0 0.8645699971941921 36 P53350,Q96GD4,Q96DY7,Q14004 4 +Axon development 0.3305221975233026 0.8495770524756604 0.3955602745503586 1.0 0.8648448430321894 72 Q96G23,P53990,P49841,P30536,P41440,P42892 6 +Centrosome duplication 0.4282727434545105 0.8495099783628338 0.3955975801979312 1.0 0.8648448430321894 15 P24941 1 +Rna stabilization 0.3937804741649847 0.848262157902044 0.3962919873951342 1.0 0.865003829481249 26 Q92615,P07910,Q92804,P35637,Q13151,Q14011,P67809,P98175,Q9Y2W1 9 +B cell differentiation 0.4971781180197948 0.8470391862651938 0.3969732799043191 1.0 0.865003829481249 9 P55327,P00813 2 +Cardiac conduction system development 0.7771615008156573 0.8461554583588847 0.3974660261574607 1.0 0.8651925657943909 2 P60953 1 +Manganese ion transmembrane transport 0.7768352365415918 0.8449466459661407 0.3981406289094815 1.0 0.8660710549218844 2 Q9HD20 1 +Manganese ion transport 0.7768352365415918 0.8449466459661407 0.3981406289094815 1.0 0.8660710549218844 2 Q9HD20 1 +Skeletal muscle acetylcholine gated channel clustering 0.5650979866393839 0.8434404204119228 0.3989821738580292 1.0 0.8665944034728212 5 P49354,Q14696 2 +Nonribosomal peptide biosynthetic process 0.564978986657802 0.8429586915810322 0.3992515469191584 1.0 0.8666559942883281 5 Q16775,P48507 2 +Chromatin remodeling at centromere 0.5644668241290371 0.840885866343463 0.4004118770487532 1.0 0.8667515649296491 5 P84243,Q6IPU0,P49321 3 +Digestive system development 0.4564611926780689 0.8404752544514115 0.4006419704248962 1.0 0.8667515649296491 12 O94788 1 +Cellular carbohydrate catabolic process 0.421192892608497 0.8378665777228465 0.4021056415405093 1.0 0.8690180475916152 17 P49840 1 +Positive regulation of smad protein signal transduction 0.7806101423948293 0.8374300707765008 0.4023508688505068 1.0 0.8690180475916152 3 P09874 1 +Placenta development 0.4138614855956096 0.8335736221707731 0.4045212949384389 1.0 0.8712792612581631 19 Q9H6E4,Q96T37 2 +Metanephros development 0.5113639088675882 0.8315907476962057 0.4056399863240894 1.0 0.8714761016991867 7 P35610 1 +Glycosyl compound catabolic process 0.4810077193787639 0.8312871364621987 0.4058114396944099 1.0 0.8714761016991867 10 Q13126,Q9NUJ1 2 +Negative regulation of telomere maintenance 0.4411070588611214 0.830781103592124 0.4060972994763125 1.0 0.8714761016991867 13 P07910,P09651,P09874,Q9NYB0 4 +Negative regulation of protein acetylation 0.493533612858007 0.8299678193141481 0.4065569785037626 1.0 0.8714761016991867 9 P49841 1 +Purine deoxyribonucleoside monophosphate metabolic process 0.7782275473258682 0.8293469682173416 0.4069081006719131 1.0 0.8714761016991867 3 P55263 1 +Damp metabolic process 0.7782275473258682 0.8293469682173416 0.4069081006719131 1.0 0.8714761016991867 3 P55263 1 +Tetrapyrrole catabolic process 0.6234315387044893 0.8291239149722719 0.4070342925320094 1.0 0.8714761016991867 4 P09601,P30519 2 +Epithelial cell proliferation 0.3864863883088422 0.8284712180281769 0.4074036883927578 1.0 0.8719325212658878 41 Q9Y3B8,O94788,O14936,P07942,Q15418,Q9UII2,Q00577,P17252,P09601,Q8WTV0 10 +Amyloid beta metabolic process 0.4401594578879082 0.8256485694048719 0.409003474889551 1.0 0.8731280156443837 13 P49840 1 +Apoptotic cell clearance 0.5008625962392906 0.8232626809002392 0.4103586309562343 1.0 0.8749146194612885 8 Q8WTV0,Q8NBS9 2 +Rna phosphodiester bond hydrolysis 0.3395658860770932 0.8200006148858118 0.4122157566420892 1.0 0.8757690739650912 61 O15091,Q9Y3B8,Q9BQG2,Q13868,Q8N684,Q96EU6,Q16630,P78316,Q9UQ84,Q6L8Q7,Q15024,Q6UN15,Q9NQT4,Q12972,Q9BQ61 15 +Skeletal muscle organ development 0.3895807068128722 0.8184390131457671 0.4131065525948785 1.0 0.87654846534989 26 O94966,Q08209,Q92841,P17844,Q7Z406,Q9BRT2,O75446,Q9Y5Q8,P60660,P41440,Q9BYT8,Q8NEZ5,P50402,P80723 14 +Negative regulation of protein secretion 0.4779633866631238 0.8165475817504992 0.4141870212064615 1.0 0.8780679858515245 10 Q8N183,Q16850,Q16836 3 +Amyloid beta formation 0.4645717017392192 0.8164639078750596 0.4142348579787742 1.0 0.8780679858515245 11 P49840 1 +Lipid export from cell 0.7729092822507032 0.8113656966772383 0.4171556924749044 1.0 0.8788317833119096 3 P14174 1 +Regulation of organ growth 0.4890273922192542 0.8089210605854431 0.4185605539292913 1.0 0.8788317833119096 9 P49840 1 +Inositol phosphate metabolic process 0.5558222048963335 0.8060227154626831 0.4202297515216899 1.0 0.8788317833119096 5 Q9NX62,Q10713 2 +Regulation of wound healing 0.4202952701664956 0.8037063156877128 0.4215666057772509 1.0 0.8788317833119096 15 Q16625 1 +Histone h3 k4 methylation 0.3962124911380711 0.8019494229311683 0.4225822154320358 1.0 0.8788317833119096 22 P10412,Q03164,Q6UXN9,P18615,P16403,Q9H3P2 6 +Negative regulation of wnt signaling pathway 0.4004473732736218 0.7997085333500761 0.4238796877068103 1.0 0.880551707397952 21 P49840,Q96C57,P49841 3 +Nuclear transcribed mrna catabolic process deadenylation dependent decay 0.3872862885387894 0.7984712720019769 0.4245970578268234 1.0 0.880551707397952 27 Q969T7,Q5PRF9,Q6L8Q7,Q15024,P67809,Q9NQT4 6 +Regulation of homotypic cell cell adhesion 0.5284008788097913 0.7974492966670614 0.4251901388131449 1.0 0.880551707397952 6 P17252 1 +Regulation of neurotransmitter levels 0.388050234167152 0.7972140486310277 0.4253267283269406 1.0 0.880551707397952 32 P35080,Q4J6C6,P49841,Q99808,P20339,P41440 6 +Histone h2a acetylation 0.4477170042827713 0.7949683731600442 0.4266318996526799 1.0 0.8807958898069824 12 Q9NV56,Q9UBU8 2 +Regulation of tube size 0.4849532902497638 0.7899551675281479 0.4295539512933852 1.0 0.8840943468160212 9 P42892 1 +Regulation of epidermis development 0.4848738131920062 0.7895858058891192 0.4297697003915708 1.0 0.8840943468160212 9 Q9Y3B8 1 +Mitochondrial atp synthesis coupled proton transport 0.4582149954479746 0.7846418392943704 0.4326635918981929 1.0 0.8852251682182573 11 P00846 1 +Histone h2b ubiquitination 0.5503786343719281 0.7841972834575534 0.4329243588971367 1.0 0.8852251682182573 5 Q8N7H5,Q5VTR2 2 +Positive regulation of synaptic transmission 0.4092158527505058 0.7840926852577542 0.4329857271906867 1.0 0.8852251682182573 18 P41440 1 +Positive regulation by symbiont of entry into host 0.7601957585644252 0.7838560754132188 0.4331245659550133 1.0 0.8852251682182573 2 P07237 1 +Ventricular system development 0.4921441601246155 0.7835533945948437 0.4333022116227454 1.0 0.8853051261128407 8 P49454,Q9H6E4 2 +Tooth mineralization 0.7585644371941143 0.7779292785677386 0.4366107066136253 1.0 0.8888611657174651 2 Q6P4Q7 1 +Amelogenesis 0.7585644371941143 0.7779292785677386 0.4366107066136253 1.0 0.8888611657174651 2 Q6P4Q7 1 +Enamel mineralization 0.7585644371941143 0.7779292785677386 0.4366107066136253 1.0 0.8888611657174651 2 Q6P4Q7 1 +Response to extracellular stimulus 0.3363943553612822 0.776744264668455 0.4373096656789828 1.0 0.8897184677996756 83 P35610,O94788,Q9UMX5,P80303,O95831,P30536,P53985,Q8NEZ5 8 +Endothelial cell migration 0.3844210743457069 0.7731775005191261 0.4394173398161911 1.0 0.892643344155528 34 P42785 1 +Retinal ganglion cell axon guidance 0.6077495428963665 0.7705372615774697 0.4409812606809618 1.0 0.8935672913798436 4 Q13740,P83731 2 +Embryonic hemopoiesis 0.5468711659685984 0.7701912762230849 0.4411864379921084 1.0 0.8936996910325087 5 Q9H6E4 1 +Regulation of double strand break repair 0.3824707141186446 0.7689427288281876 0.4419273100919918 1.0 0.8939468866097247 37 Q9NV56,P09874,Q7Z4V5,P35637,Q9UBU8,Q9NPF5,Q9NY27 7 +Cellular modified amino acid metabolic process 0.362464652468724 0.7684790104621233 0.4422026559137753 1.0 0.8939468866097247 51 Q8NCC3,O60725,P41440,Q9UHG3,Q9H7Z7 5 +Regulation of epithelial cell migration 0.3799660270344831 0.7681397178838116 0.4424041825986733 1.0 0.8939468866097247 40 P35080,Q14185,Q13685,P06576,P42785,P17252,Q8WTV0 7 +Purine deoxyribonucleoside triphosphate metabolic process 0.760012890621433 0.7681371957291969 0.4424056808577896 1.0 0.8939468866097247 3 P55263 1 +Regulation of animal organ morphogenesis 0.5208490424093907 0.7656829348317358 0.4438649834947576 1.0 0.8939468866097247 6 Q13308,Q8TAA9,P60953 3 +Dicarboxylic acid metabolic process 0.3781374212943734 0.7617602535556356 0.4462031064753664 1.0 0.8939468866097247 41 P30520,P41440 2 +Ceramide metabolic process 0.4020851834998358 0.7606946666066405 0.4468394611399415 1.0 0.8939468866097247 19 Q8NCC3,Q96G23 2 +Mitotic chromosome condensation 0.4530119352360732 0.7587327875381613 0.4480124192161505 1.0 0.8945607526246474 11 P53350,O43823 2 +Response to uv 0.380884228041679 0.7567954484613603 0.4491724201070837 1.0 0.8945607526246474 37 Q96GD4,Q15004,Q96RU2,P09874,Q6IQ49,P27544,Q14011 7 +Skeletal system development 0.3762806201181174 0.7559422498458982 0.4496838211387683 1.0 0.8945607526246474 42 Q13428,Q32P28,Q96HY6,P08133,O75844 5 +Regulation of glycoprotein metabolic process 0.4399299542881635 0.7547527070519183 0.4503973750700323 1.0 0.8948788138888247 12 Q9NQX7 1 +Membrane disassembly 0.4935861738173062 0.7525508231961346 0.4517198783443219 1.0 0.8962140607387565 7 P53350 1 +Ossification 0.3452680314551662 0.7508768207907327 0.4527267912997144 1.0 0.8967732282876764 57 Q9NX62,Q14696,P06576,P38159,P49841,P17252,O75844,P84243 8 +Neuron intrinsic apoptotic signaling pathway in response to oxidative stress 0.6024339448948475 0.7508754847417638 0.4527275954395313 1.0 0.8967732282876764 4 P09874 1 +Transition metal ion transport 0.4253305186385874 0.7459378988273045 0.4557049299564033 1.0 0.9006720832152503 13 Q9HD20,Q15043,Q8TAD4,Q9H9B4,O15173,Q07960 6 +Somatic diversification of immunoglobulins 0.3994072069165247 0.7442548093011507 0.4567223351056866 1.0 0.9017286448868992 19 Q9UQ84 1 +C4 dicarboxylate transport 0.4834225270935085 0.7441213163769871 0.4568030843968986 1.0 0.9017286448868992 8 Q8TDW0,Q8IWT6 2 +Iron ion transmembrane transport 0.7491027732463287 0.7437927114274855 0.4570018902814134 1.0 0.9017286448868992 2 Q15043 1 +Iron coordination entity transport 0.7491027732463175 0.7437927114274459 0.4570018902814374 1.0 0.9017286448868992 2 O15173 1 +Heme transport 0.7491027732463175 0.7437927114274459 0.4570018902814374 1.0 0.9017286448868992 2 O15173 1 +Positive regulation of glial cell proliferation 0.75239855797555 0.7428833055165739 0.4575523338687981 1.0 0.9018381016848164 3 P30536 1 +Response to thyroid hormone 0.5151888533944796 0.7420187204433779 0.4580759933288834 1.0 0.9021767868612922 6 Q15648,P48507,Q9Y376 3 +Retrograde transport endosome to golgi 0.3797333099288724 0.7363295035529037 0.4615301953299369 1.0 0.9054326769519716 31 Q8N1B4,Q4J6C6,Q96JG6,P51151,O15260 5 +Positive regulation of endothelial cell migration 0.3942198432779327 0.7342271736978626 0.4628102945999912 1.0 0.906565915430881 20 P17252,Q8WTV0,Q13685,P06576 4 +Lung epithelium development 0.5373835285338241 0.7325473371553886 0.4638345610033809 1.0 0.9067826842804232 5 P09960 1 +Coenzyme a metabolic process 0.4890287994815342 0.7324864034594203 0.4638717385311426 1.0 0.9067826842804232 7 P35610 1 +Arachidonic acid metabolic process 0.5128607546880483 0.7323241735379343 0.4639707281011369 1.0 0.9067826842804232 6 P07099 1 +Regulation of biomineralization 0.5126496245041914 0.7314461578335439 0.4645066804011453 1.0 0.9067826842804232 6 O75844 1 +Optic nerve development 0.745513866231632 0.7309555654410258 0.4648062943826754 1.0 0.9067826842804232 2 Q9H061 1 +Regulation of dna templated transcription elongation 0.3763789782243693 0.730480057639007 0.4650967984777385 1.0 0.9067826842804232 25 Q9H3P2,Q14004 2 +Neutral amino acid transport 0.5112437460909209 0.7256046216476044 0.4680811870496566 1.0 0.9109338813746514 6 Q9H9B4,Q15758,Q96NB2 3 +Regulation of t cell proliferation 0.4018920359606011 0.7236553087818512 0.4692773766992606 1.0 0.9113690699808276 17 P04439,P30825,P98172 3 +Rna phosphodiester bond hydrolysis exonucleolytic 0.3796121439355989 0.7234109054095655 0.4694274732251497 1.0 0.9113690699808276 23 Q9Y3B8,Q6L8Q7,Q15024,Q9NQT4,Q9BQ61 5 +Negative regulation of glycoprotein metabolic process 0.7464099216710458 0.7231728448190349 0.4695736999462179 1.0 0.9113690699808276 3 Q9NQX7,Q9NY61 2 +Response to metal ion 0.3417869930225741 0.717422759950851 0.4731132801612734 1.0 0.9136123405987642 57 O60888,P09874,Q8TAD4,P30536,P06493 5 +Plasma lipoprotein particle clearance 0.4445031915945847 0.7166639597434835 0.4735814689255617 1.0 0.9141223702516657 11 Q8WTV0,P35610 2 +Regulation of plasma lipoprotein particle levels 0.4064163262944869 0.7162564498662011 0.4738330124924119 1.0 0.9143317581035644 14 P61978,P35610,P17252,P09601,Q8WTV0 5 +Neutrophil differentiation 0.5921184960990812 0.713039519240913 0.4758213030404095 1.0 0.9157341380132048 4 Q14739 1 +Calcium mediated signaling 0.3941633528126955 0.7122270060533578 0.4763242162930217 1.0 0.9157341380132048 19 O75844,P49841 2 +Epithelial to mesenchymal transition 0.3777599658671173 0.7110044903847984 0.4770814532065202 1.0 0.9157341380132048 23 Q14978,P49841 2 +Dna dependent dna replication 0.3199832593726477 0.706938491805426 0.4796047022725012 1.0 0.9182605309237734 74 O75844,P24941,P41440 3 +Atp synthesis coupled proton transport 0.4302965029832574 0.7054757744119073 0.4805142027822611 1.0 0.9184030735872832 12 P00846 1 +Positive regulation of gliogenesis 0.466611420971771 0.7054321099884319 0.4805413672470466 1.0 0.9184030735872832 9 P30536 1 +Positive regulation of peptidyl serine phosphorylation 0.4027167197067142 0.7041610518036527 0.4813324832037824 1.0 0.9184667300966912 15 P35080,P14174 2 +Carbohydrate transport 0.3983734081819235 0.7031211628855106 0.4819802445901251 1.0 0.9184667300966912 17 P49840 1 +Dendritic transport 0.5056750132320487 0.7025545859428399 0.4823333727301997 1.0 0.9184667300966912 6 Q00577,P23246 2 +Protein kinase a signaling 0.4739499158152568 0.7016763421781809 0.4828810300486277 1.0 0.9184667300966912 8 P14174 1 +Regulation of cell division 0.3721806764024376 0.7014383198861013 0.4830295147059602 1.0 0.9184667300966912 25 Q96GD4,Q9Y3B8,Q8WYP5,Q9H0H5,P53350 5 +Regulation of protein secretion 0.3728718069183359 0.7004248698828793 0.4836620093224553 1.0 0.9184667300966912 38 Q32P28,Q8N183,Q16850,P53985 4 +Ribonucleoside monophosphate metabolic process 0.3738679820139404 0.7002091130602845 0.4837967212534744 1.0 0.9184667300966912 28 P30520,O14936,P00813,P11908,P55263 5 +Cerebral cortex radially oriented cell migration 0.4814875923060963 0.6994917434679283 0.484244771105804 1.0 0.9184667300966912 7 Q96N66 1 +Telencephalon glial cell migration 0.4814875923060963 0.6994917434679283 0.484244771105804 1.0 0.9184667300966912 7 Q96N66 1 +Regulation of phosphatidylinositol 3 kinase activity 0.528667020801101 0.6983045222987686 0.4849867716827027 1.0 0.9184667300966912 5 P07948,A4D1P6,O00459 3 +Lysosomal protein catabolic process 0.5045849491900524 0.6980597423123852 0.4851398331049559 1.0 0.9184667300966912 6 Q8N511 1 +Protein catabolic process in the vacuole 0.5045849491900524 0.6980597423123852 0.4851398331049559 1.0 0.9184667300966912 6 Q8N511 1 +Exonucleolytic catabolism of deadenylated mrna 0.4649710751788977 0.6979513906216048 0.485207593988824 1.0 0.9184667300966912 9 Q969T7,Q9NQT4,Q15024 3 +Positive regulation of lipid transport 0.4649520489874795 0.6978647060662619 0.4852618083887297 1.0 0.9184667300966912 9 P14174 1 +Protein stabilization 0.3133456771192137 0.696677686327137 0.4860045261289891 1.0 0.9184667300966912 69 Q32P28,O75718,P41440 3 +Positive regulation of protein localization to nucleus 0.3733249695953159 0.6955804878387477 0.4866915892381294 1.0 0.9184667300966912 36 P53350,P06493,P09874,O00459 4 +Positive regulation of leukocyte cell cell adhesion 0.3702483565307374 0.6939785539876502 0.4876956583516305 1.0 0.9196998974698348 24 P07948,P04439,P00813,P30825,P98172 5 +Transition between fast and slow fiber 0.7347471451876023 0.6928365314996848 0.488412143623026 1.0 0.9200629691600132 2 Q08209 1 +Positive regulation of heart rate 0.7347471451875864 0.6928365314996293 0.4884121436230608 1.0 0.9200629691600132 2 P00813 1 +Response to interleukin 7 0.4634909146899358 0.6912134929849024 0.4894313857111485 1.0 0.9206779597869288 9 P67809,P06576,P07237 3 +Protein localization to microtubule organizing center 0.4633826266748868 0.690721016420575 0.4897408793821771 1.0 0.9207420984599088 9 Q14789,P49841,P25054,Q14980,Q13561 5 +Regulation of translation in response to stress 0.4515485489402142 0.690352305178819 0.4899726624772857 1.0 0.9207420984599088 10 Q13217,Q15418,Q9BWF3 3 +Intrinsic apoptotic signaling pathway 0.3150626614461164 0.6903451896309837 0.4899771361073619 1.0 0.9207420984599088 71 P61978,Q9Y3B8,Q96RU2,P07237,Q8IXB1,P09874,Q9NR28,O95831,Q15233,P14174,Q96K76,O95881 12 +Regulation of superoxide anion generation 0.5857458056444234 0.6898933011080622 0.4902612888373321 1.0 0.9210052607170456 4 P04899,Q9NY61 2 +Release of cytochrome c from mitochondria 0.4000135579540353 0.6890556276157288 0.4907882619411201 1.0 0.9215458070462292 15 Q96A26,Q9Y3B8 2 +Glycine metabolic process 0.5016769310201253 0.6860972350555659 0.4926517943803075 1.0 0.9223896979592958 6 O75600 1 +Cristae formation 0.4704199576839599 0.6859729657085375 0.4927301562874411 1.0 0.9223896979592958 8 Q9Y4W6 1 +Positive regulation of mitochondrial depolarization 0.7341838813149522 0.6833786656877064 0.4943675974405079 1.0 0.9232959017949236 3 P30536 1 +Tumor necrosis factor superfamily cytokine production 0.3948967767205176 0.6829346460277406 0.4946481401500089 1.0 0.9232959017949236 17 P30536,P14174 2 +Mrna splice site selection 0.3920719090299144 0.6815361028407049 0.4955323305675154 1.0 0.9241164647379606 18 Q9Y383,Q15637,Q13243,Q13247,O75494,Q92879,Q9UKA9,Q15459,O95319,Q15428,Q13242,Q07955 12 +Response to interleukin 1 0.4125802319930061 0.6784956790763971 0.4974574625662753 1.0 0.9265520833361076 13 P17252,P38159 2 +Animal organ regeneration 0.396039145336886 0.6769252817633644 0.4984533624917557 1.0 0.92755400129693 16 P06493 1 +Regulation of cell cycle phase transition 0.3485944708763919 0.6767439754502319 0.4985684098699705 1.0 0.92755400129693 103 Q96GD4,Q9Y619,Q96RU2,P49454,Q96DY7,Q8N6R0,Q96HY6,P53350,P06493,P24941,Q68E01 11 +Muscle cell proliferation 0.3811753986204879 0.6763366000975652 0.4988269601717334 1.0 0.92755400129693 21 P06493 1 +Insulin metabolic process 0.5815502786676928 0.6747569565626836 0.4998301914578473 1.0 0.9277959205477596 4 Q8TAD4 1 +Ncrna transcription 0.3674145286468953 0.6746361832031227 0.4999069386379196 1.0 0.9277959205477596 24 Q13428,P19338,Q9H2V7,Q9Y5Q8,O15446,P46100 6 +N terminal peptidyl methionine acetylation 0.7288743882544707 0.6723064924431551 0.5013885973921739 1.0 0.9277959205477596 2 Q5VZE5 1 +Mitochondrial translation 0.3633708881571596 0.672006568322093 0.501579514808159 1.0 0.9277959205477596 44 Q8NC60,Q9HD33,P82914,Q6P087,Q567V2,P82673,Q9BRT2,P34897,Q92552,Q9NSE4,Q96EY7,Q9NX20,Q5JTZ9 13 +Low density lipoprotein particle clearance 0.447136442756562 0.669631886684048 0.5030924818957554 1.0 0.9295357189348866 10 Q8WTV0,P35610 2 +Regulation of signal transduction by p53 class mediator 0.370440518006205 0.6687140130072213 0.503677926861775 1.0 0.9298109851454665 32 Q96GD4,O75844,P14174 3 +Protein localization to chromosome 0.3614431764026206 0.6673218523998111 0.5045665709783538 1.0 0.9302993817276998 45 Q96GD4,O14773,Q96DY7,Q8NEY8,P53350,P06493,P46100 7 +Peptidyl methionine modification 0.7291122715404741 0.6670581404624201 0.5047349966881653 1.0 0.9302993817276998 3 P53582,Q5VZE5 2 +Cellular response to exogenous dsrna 0.4661192443816674 0.6669315223452018 0.5048158747976315 1.0 0.9302993817276998 8 P41440 1 +Neurotransmitter catabolic process 0.7259380097879281 0.6621145536888483 0.5078978093283433 1.0 0.9315905675513276 2 P51649 1 +Cellular carbohydrate metabolic process 0.330147553063024 0.660826707169109 0.5087234532961564 1.0 0.9318133879189268 59 Q9NX62,O14874,Q10713,P49840,P49841,O75844,P48735,Q9NUJ1 8 +Negative regulation of mrna 3 end processing 0.4953139784906981 0.6600741365929438 0.5092062550082139 1.0 0.9318133879189268 6 P18615 1 +Circadian rhythm 0.3641707387739914 0.659619979552363 0.5094977295349328 1.0 0.9318133879189268 42 Q8WXF1,Q9BQG2,Q03164,P49841,Q15233,P54802,P06493 7 +Pyrimidine deoxyribonucleotide metabolic process 0.51861599463903 0.6592739664852888 0.509719856699197 1.0 0.9318133879189268 5 P78549 1 +Heart morphogenesis 0.3735652597531878 0.6537842785935487 0.5132507965850364 1.0 0.9339201669507656 22 P49840,O94788 2 +Demethylation 0.3917832220403163 0.6528916073473308 0.5138261599396143 1.0 0.9344879044427048 16 Q16850,Q8NB78 2 +Monocarboxylic acid biosynthetic process 0.3659320698610111 0.6526824228532025 0.5139610364756857 1.0 0.9344879044427048 39 O94788,Q9BY49,Q8IVS2,O95864,P28288,P14174,Q9H4L5,Q9H7Z7 8 +Protein processing involved in protein targeting to mitochondrion 0.7243751404851471 0.6519188479248823 0.5144535253310831 1.0 0.9348514303073509 3 Q10713 1 +Response to gamma radiation 0.3929681467611629 0.6499828739687461 0.515703284142754 1.0 0.9360578497461916 15 O75844 1 +Postsynaptic membrane organization 0.4698288760671085 0.6490504282606636 0.5163057817019931 1.0 0.936088014427642 7 P49354,Q14696 2 +Prostanoid biosynthetic process 0.4921028901119805 0.647024764754545 0.5176159157899229 1.0 0.9373996366714076 6 P14174 1 +Response to radiation 0.3176496097141886 0.6444902446926744 0.5192575815082239 1.0 0.9385175457031898 77 Q96GD4,Q15004,Q96RU2,P09874,P22830,P27544,Q68E01,O75844,P46100,Q14011 10 +Hematopoietic stem cell homeostasis 0.5718537299277642 0.6401066943285713 0.5221032371540393 1.0 0.9385175457031898 4 Q14157 1 +Positive regulation of reproductive process 0.5132408887197085 0.638620466316316 0.5230698638261839 1.0 0.9387642515341594 5 Q07021,Q8IY37 2 +Intracellular mrna localization 0.7184339314844947 0.6362993622726342 0.5245813205390617 1.0 0.9401568198444036 2 Q99729 1 +Lipid import into cell 0.4883767657743023 0.6319562662542038 0.5274154550321777 1.0 0.9409866240819488 6 P33121,O14975 2 +Regulation of embryonic development 0.3860116228202742 0.6318539147606499 0.5274823396845942 1.0 0.9409866240819488 17 P06493 1 +Telomere capping 0.4035958737086825 0.631722081063474 0.5275684967410159 1.0 0.9409866240819488 13 Q96GD4,Q9NYB0,Q92878,P49959 4 +Production of molecular mediator of immune response 0.3651917375686035 0.6314252908477329 0.5277624838153445 1.0 0.9409866240819488 34 P20585,Q9UQ84,P14174 3 +Positive regulation of cell population proliferation 0.3504459080710299 0.6310787229845319 0.5279890524108697 1.0 0.9409866240819488 109 Q14978,Q14004,O94788,P07942,P00813,Q96HY6,P30825,P30536,P14174,P06493,P24941,P98172 12 +Response to oxidative stress 0.3346939506380269 0.6286265503796825 0.5295935741548146 1.0 0.9417452789158096 94 P03915,P28074,P07237,Q15165,P09874,Q15392,O95831,Q9NR28,Q99720,P30519,P06493,Q7Z2K6,P39210 13 +Negative regulation of g protein coupled receptor signaling pathway 0.4868532228840863 0.625818684550046 0.5314338749717273 1.0 0.94369016549293 6 P31946,P00813,Q9NWH9 3 +Cerebral cortex cell migration 0.4565339394814179 0.6248815629199914 0.5320487938280825 1.0 0.9437614956710416 8 Q96N66 1 +Neural tube development 0.368928715901397 0.6240825983986725 0.5325733414599252 1.0 0.9441542927241005 22 P25440,O94788 2 +Heart development 0.3108645625742864 0.6196649953937734 0.5354783661268194 1.0 0.9469402982613456 73 P06493,P49840,O75844,O94788 4 +Mrna pseudouridine synthesis 0.5656633664139343 0.6182445649807633 0.5364141376036256 1.0 0.9473680727753876 4 Q96PZ0 1 +Deoxyribonucleoside triphosphate catabolic process 0.5077916325464541 0.6178505173031608 0.5366738796925252 1.0 0.9473680727753876 5 P00813 1 +Nucleoside triphosphate catabolic process 0.5077916325464541 0.6178505173031608 0.5366738796925252 1.0 0.9473680727753876 5 P00813 1 +Regulation of superoxide metabolic process 0.5068707988306336 0.614358212565595 0.5389786428956638 1.0 0.9482033511208808 5 P04899,Q9NY61 2 +Protein targeting 0.3477507112551144 0.6132073763059098 0.5397392280622197 1.0 0.9482033511208808 108 P55786,Q99595,Q9NS69,Q7L5D6,Q9H173,Q10713,P49840,O75381,O95831,O60725,Q7Z3T8,P30536,Q15629,O60830 14 +Serine family amino acid catabolic process 0.7115823817291871 0.6130317336459085 0.5398553571551492 1.0 0.9482033511208808 2 P34897 1 +Forebrain cell migration 0.4460032518307185 0.6125851982427695 0.540150647833552 1.0 0.9482033511208808 9 Q96N66 1 +Mitochondrial dna metabolic process 0.460730365332831 0.6102316027851032 0.5417083979195203 1.0 0.9489872995687384 7 P09874 1 +Cellular response to dsrna 0.4340953847713698 0.6091346503331758 0.5424351918417041 1.0 0.949261585722982 10 P41440 1 +Macrophage differentiation 0.4601496063796441 0.6077716007286703 0.5433389671893551 1.0 0.9497314502329468 7 P17252,P09874 2 +Positive regulation of dna repair 0.3618554132439535 0.6069373017814971 0.543892521960974 1.0 0.9497314502329468 33 Q9NV56,P09874,Q7Z4V5,P35637,Q9UBU8 5 +Regulation of cholesterol biosynthetic process 0.5614673633972929 0.6035479651176073 0.5461442169233965 1.0 0.9518428389303047 4 Q9UBM7,O75477 2 +Regulation of alcohol biosynthetic process 0.5614673633972929 0.6035479651176073 0.5461442169233965 1.0 0.9518428389303047 4 Q9UBM7,O75477 2 +Dicarboxylic acid transport 0.3806158854831322 0.6012295431099108 0.5476871098597338 1.0 0.9532714988870816 17 Q9BQT8,P41440 2 +Protein maturation 0.3045765738546442 0.59909983702034 0.5491063103569531 1.0 0.9543316638785846 65 Q5JRX3,Q9Y4W6,Q10713,P09874,Q6IQ49,Q15392,Q8TAD4,Q9BU89,P17252,Q96F07,O75844,P42892,Q5VZE5,Q13162 14 +Regulation of b cell activation 0.3800431171553649 0.5979977391151922 0.5498414416534447 1.0 0.9543316638785846 17 P00813,P14174 2 +Antibacterial humoral response 0.7070146818923188 0.597688153762458 0.5500480312873652 1.0 0.9543316638785846 2 P04439 1 +Regulation of protein acetylation 0.3683510948551863 0.5962542556179303 0.5510053853288255 1.0 0.9551058903272373 21 O75844,Q9NYB0,P49841,Q01105 4 +Production of sirna involved in rna interference 0.7058937828141973 0.5938955044067004 0.5525820060498627 1.0 0.95706005438067 3 Q15631 1 +Dna recombination 0.3324606713653277 0.593548546489418 0.5528141039391143 1.0 0.9572026383838744 95 P10412,Q9NV56,P07305,P09874,Q7Z4V5,Q9NYB0,Q15233,P20585,Q9UQ84,P35637,Q68E01,Q9NPF5,Q9NY27,Q9UBU8,P46100 15 +Phosphatidylinositol dephosphorylation 0.7051688535636824 0.59165534972249 0.5540814016253099 1.0 0.9575809188175652 3 Q10713 1 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.7047308319738846 0.5900684935115651 0.5551447305764792 1.0 0.9580681466923138 2 P04439 1 +Positive regulation of establishment of protein localization 0.3233702858367455 0.5877386469659622 0.5567077308043848 1.0 0.9595251099166192 87 Q9Y282,P55786,Q9Y3B8,O00459,Q9GZY8,P49840,P49841,Q9NPF5,P06493,P50402,P49755 11 +Smooth muscle contraction 0.4766681414664196 0.5851625854771519 0.5584383997043361 1.0 0.9619891677925636 6 P00813 1 +Organophosphate catabolic process 0.3581349793598471 0.5832578259278136 0.5597197488531465 1.0 0.9622400023773656 36 Q9NX62,Q8NHP8,P35610,Q10713,Q8NCC3,P00813,Q9H773,Q9BW91,Q8WTV0,P78549 10 +Abscission 0.702363752209703 0.5830139300654394 0.5598839227578043 1.0 0.9622400023773656 3 Q96GD4 1 +Muscle hypertrophy in response to stress 0.7013707571801586 0.5799652241913635 0.5619380694440375 1.0 0.9643786793278312 3 Q08209,P16615 2 +Regulation of cardiac muscle adaptation 0.7011419249592145 0.5781666968020811 0.5631515807675971 1.0 0.9651653935869436 2 Q08209 1 +Membrane protein ectodomain proteolysis 0.4269947094829355 0.5767214750637699 0.564127622939161 1.0 0.9655435560268284 10 P38159 1 +Icosanoid biosynthetic process 0.4377415356284702 0.576150379357892 0.5645135414578863 1.0 0.9656868424671712 9 P14174 1 +Regulation of dna duplex unwinding 0.5534535535705888 0.5757694740172611 0.5647710092464213 1.0 0.9658687503596144 4 P49736,P33993 2 +Regulation of platelet derived growth factor receptor beta signaling pathway 0.6991843393148356 0.5717125520325723 0.5675167293312509 1.0 0.966627895380576 2 O00291 1 +Positive regulation of cell substrate adhesion 0.3538985554994037 0.5716151430687902 0.5675827341075002 1.0 0.966627895380576 26 Q14185,P07237,P60953,P49593,Q13464,P49841,Q92766,P46939 8 +Response to organic cyclic compound 0.394866390368549 0.5687100891382256 0.5695528998264332 1.0 0.966627895380576 164 P07099,Q9NUD5,P30520,P35610,O94788,Q13126,P49840,P09874,O95831,P49841,Q96HY6,P30536,P41440,P06493,P53985,P49721 16 +Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process 0.5512247531802406 0.5681143484734384 0.56995732545453 1.0 0.966627895380576 4 P49755 1 +Regulation of aspartic type peptidase activity 0.5512247531802406 0.5681143484734384 0.56995732545453 1.0 0.966627895380576 4 P49755 1 +Positive regulation of actin filament polymerization 0.435452636586235 0.5661473339571422 0.571293628342219 1.0 0.966627895380576 9 P35080 1 +Fatty acyl coa biosynthetic process 0.4023028197491589 0.5661244318229252 0.5713091958176861 1.0 0.966627895380576 12 Q9UMR5 1 +Alpha amino acid metabolic process 0.304560419660506 0.5639114449257604 0.5728144006848614 1.0 0.9668478332666708 72 P30520,P35610,Q9BQT8,Q13126,O60725,O75600 6 +Regulation of histone h3 k4 methylation 0.3770128646223549 0.5633305885638286 0.5732097927383757 1.0 0.9668478332666708 15 Q9H3P2,P18615 2 +Positive regulation of type i interferon production 0.3716430447864878 0.5629621965935259 0.573460626200589 1.0 0.9668478332666708 18 P41440 1 +Recombinational repair 0.3303436728531256 0.5627290080777357 0.5736194282202267 1.0 0.9668478332666708 55 Q9NV56,P09874,Q7Z4V5,P35637,Q68E01,Q9NPF5,Q9UBU8,P46100 8 +Positive regulation of dna methylation dependent heterochromatin assembly 0.4704350182024518 0.5606254452458258 0.5750529014930219 1.0 0.9674027621589636 6 Q8NEY8 1 +Aspartate family amino acid catabolic process 0.4487180783461174 0.5598243808223445 0.575599231949913 1.0 0.967782585277682 7 Q9BQT8 1 +Negative regulation of bmp signaling pathway 0.5487108070973256 0.5595181219316447 0.5758081670091144 1.0 0.967782585277682 4 Q05D32 1 +Regulation of reproductive process 0.3893929004509721 0.5593034071218038 0.5759546704808511 1.0 0.967782585277682 13 P00813,Q8IY37 2 +Negative regulation of neuron death 0.354902060899804 0.5584458315452476 0.5765399839317853 1.0 0.9679597375543262 32 Q9UMX5,Q13464,P49841,Q15233,Q01105 5 +Peroxisome fission 0.5483921589531635 0.5584314708300081 0.5765497878110817 1.0 0.9679597375543262 4 Q9GZY8 1 +Lymphocyte activation involved in immune response 0.3507749187776612 0.5565964463610235 0.5778031822972012 1.0 0.9679597375543262 25 Q9UQ84 1 +Centromere complex assembly 0.4224515165074041 0.556199986606561 0.5780741483886151 1.0 0.9679597375543262 10 P49454,Q92674 2 +Regulation of calcium mediated signaling 0.440319087571885 0.5551472960356387 0.578793914728776 1.0 0.9679597375543262 8 P49841 1 +Positive regulation of cold induced thermogenesis 0.4107926831663406 0.5547651236925576 0.5790553252663577 1.0 0.9680205555263648 11 P33121,P23786,Q16836 3 +Atp biosynthetic process 0.3676385214065982 0.5543807858028346 0.5793182729652468 1.0 0.968028034190827 19 P09874,P00846 2 +Positive regulation of proteolysis 0.3125507709936617 0.5539479220143132 0.5796144871170998 1.0 0.968028034190827 80 P49840,Q9NR28,P49841,O95831,Q96HY6,Q96F07,P53350,P53990,Q8NEZ5 9 +Myeloid progenitor cell differentiation 0.693311582381724 0.5525141819678655 0.5805961206120012 1.0 0.9680641290976518 2 Q92785 1 +Establishment of pigment granule localization 0.6907267544421767 0.5476363283255925 0.583941639678885 1.0 0.9711087741836466 3 Q9Y4I1 1 +Convergent extension 0.6903752039151679 0.5430095269990219 0.5871232429532673 1.0 0.9738657268918588 2 Q13308 1 +Positive regulation of dna binding transcription factor activity 0.3525242176352586 0.5426600491641548 0.5873638858264156 1.0 0.9740120898590094 36 P41440 1 +Intracellular estrogen receptor signaling pathway 0.3626692591550169 0.5419799021017779 0.5878323512041743 1.0 0.9740583830916808 20 Q96HY6 1 +Pointed end actin filament capping 0.6900489396411069 0.5419574230184842 0.587847837087832 1.0 0.9740583830916808 2 Q9NYL9 1 +Vacuolar acidification 0.4297158755298981 0.5412623030305083 0.5883267996741661 1.0 0.9744558598126376 9 Q8N511 1 +Negative regulation of mrna catabolic process 0.3473207172392777 0.5404021620221637 0.5889197171424199 1.0 0.9744558598126376 24 Q92615,P07910,Q92804,P35637,Q13151,Q14011,P67809,P98175 8 +G protein coupled receptor signaling pathway involved in heart process 0.6877650897226648 0.5346151888324575 0.5929159784733442 1.0 0.9760475732819528 2 P60953 1 +Regulation of myotube differentiation 0.6862563655892777 0.5342566631483979 0.5931639708644405 1.0 0.9760475732819528 3 Q8NEZ5 1 +Tissue migration 0.3354382778097515 0.5332626749167072 0.5938517613694385 1.0 0.9760475732819528 51 P35080,Q14185,Q13685,P06576,Q13464,P42785,P17252,Q8WTV0 8 +Response to gonadotropin 0.6871125611745478 0.5325246885861024 0.5943626471763013 1.0 0.9760475732819528 2 P48507 1 +Cellular response to follicle stimulating hormone stimulus 0.6871125611745478 0.5325246885861024 0.5943626471763013 1.0 0.9760475732819528 2 P48507 1 +Response to follicle stimulating hormone 0.6871125611745478 0.5325246885861024 0.5943626471763013 1.0 0.9760475732819528 2 P48507 1 +Cellular response to gonadotropin stimulus 0.6871125611745478 0.5325246885861024 0.5943626471763013 1.0 0.9760475732819528 2 P48507 1 +Histone h4 acetylation 0.3459219321134458 0.5312798989661209 0.5952248326297038 1.0 0.9760475732819528 24 Q9NV56,O75844,Q9UBU8 3 +Hormone mediated signaling pathway 0.3482543019707893 0.5299814740660992 0.5961247755393937 1.0 0.9760475732819528 41 P09874,P42785,Q96HY6,P33121,O15173 5 +Cellular response to uv 0.3490754260040868 0.5296727346428344 0.5963388551365014 1.0 0.9760475732819528 28 Q96GD4,Q96RU2,P09874,Q6IQ49,P27544 5 +Maintenance of cell polarity 0.4620486234202742 0.5280623135153798 0.5974560867537737 1.0 0.9760475732819528 6 P49841 1 +Negative regulation of cellular macromolecule biosynthetic process 0.3303507505941054 0.5273228117897953 0.5979694355486478 1.0 0.9760475732819528 99 P07910,Q13868,P49840,Q13464,Q00577,Q96PZ0,P51116,P49841,Q92945,Q6L8Q7,Q9NQT4,P12270,Q969T7,P19338,P34897,P27544,Q15024,Q9NQX7,Q29RF7,Q14011,Q9BWF3,Q10713,Q9NY61,Q5PRF9,P09651,Q99543,P67809 27 +Negative regulation of excitatory postsynaptic potential 0.685481239804234 0.5273127339291057 0.5979764328016062 1.0 0.9760475732819528 2 Q13614 1 +Translational readthrough 0.6854812398042265 0.5273127339290814 0.597976432801623 1.0 0.9760475732819528 2 P57772 1 +Digestion 0.3939623243101914 0.5259922393700968 0.5988935990807702 1.0 0.97606961582204 12 Q8WTV0 1 +Rna phosphodiester bond hydrolysis endonucleolytic 0.3470097504215661 0.5258535117537086 0.5989899911209577 1.0 0.97606961582204 26 P78316,O15091,Q9UQ84 3 +Extrinsic apoptotic signaling pathway 0.3497276148564467 0.5246020441974143 0.5998598653852496 1.0 0.976317225917787 37 P49840,P49841 2 +Protein localization to cytoskeleton 0.3684434681063208 0.5245360318734725 0.5999057653229776 1.0 0.976317225917787 16 Q14789,O15344,P49841,P29372,P25054,Q15154,Q14980,Q13561 8 +Regulation of fertilization 0.6838499184339292 0.5221213719568821 0.601585826926869 1.0 0.9764418700966844 2 Q9NVM9 1 +Nucleic acid phosphodiester bond hydrolysis 0.319092497199623 0.5198724904222316 0.6031524503064083 1.0 0.9781140091114576 89 Q13868,Q9GZR2,O95831,Q96EU6,Q9UQ84,Q12972,O15091,Q16630,Q6L8Q7,Q9NQT4,Q9Y3B8,Q14137,Q15631,Q6UN15,Q15024,P78549,O95551,Q9BQG2,Q8N684,P49959,P78316,Q9BQ61 22 +Regulation of dna methylation dependent heterochromatin assembly 0.4372002829151423 0.5125194719279079 0.608287496082009 1.0 0.980859364833083 7 Q9Y6X9,Q13263,Q8NEY8 3 +Neuron apoptotic process 0.3427337824418759 0.5090309257678043 0.6107305471529689 1.0 0.9811428724878016 44 P09874,Q9NR28,O95831,Q15233,Q99720,Q96A26,Q01105 7 +Regulation of steroid biosynthetic process 0.4118197831448515 0.5089049211376723 0.6108188703806063 1.0 0.9811428724878016 10 P30536 1 +Positive regulation of autophagy 0.3474632225240118 0.507015510675862 0.6121439354960516 1.0 0.9811428724878016 32 P49840,P49841 2 +Protein quality control for misfolded or incompletely synthesized proteins 0.4001029510218944 0.5054768422279368 0.613223959618628 1.0 0.9811428724878016 11 P46379,Q16740,P36776,Q9BUN8 4 +Fatty acid elongation 0.6779771615008113 0.5036062637831379 0.6145380900278534 1.0 0.9811428724878016 2 Q9NZ01 1 +Regulation of muscle organ development 0.4345787616938041 0.5019076279741298 0.6157324993210236 1.0 0.9811428724878016 7 P41440 1 +Regulation of mrna catabolic process 0.295301944655603 0.5015881559069899 0.6159572525440722 1.0 0.9811428724878016 69 Q92615,P08670,P07910,Q13868,Q13464,Q99729,P35637,P98175,P51116,Q92945,Q6L8Q7,Q9NQT4,Q969T7,Q92804,Q15024,Q14011,Q5PRF9,P17252,Q13151,P67809 20 +Regulation of g protein coupled receptor signaling pathway 0.3647022685343335 0.4985544428151441 0.6180933061553291 1.0 0.9811428724878016 15 P17252,P49840,P00813 3 +Osteoblast differentiation 0.3422827628726806 0.4978807820000918 0.6185680735463441 1.0 0.9811428724878016 43 P61604,O94874,P06576,P07910,P17844,P38159,P49841,Q9HBH5,P17252,P55265,Q9P2E9,P84243 12 +3 utr mediated mrna destabilization 0.4529296358937207 0.4932913983140142 0.6218067052949263 1.0 0.9816596534495816 6 Q9H2U1,Q92945,Q9HCE1 3 +Regulation of epithelial cell differentiation 0.3636359986527644 0.4930417811440937 0.6219830658356758 1.0 0.9816596534495816 15 P35611,Q9Y3B8,O14974,P35222,Q13464,Q15648,Q14980 7 +Fc epsilon receptor signaling pathway 0.6743882544861195 0.4924284700865826 0.6224164770333065 1.0 0.9816596534495816 2 P07948 1 +Positive regulation of histone ubiquitination 0.5277908869208086 0.4896757169777856 0.6243633877526231 1.0 0.9818287303064076 4 Q6PD62,Q5VTR2 2 +Dorsal root ganglion development 0.6734094616639446 0.489398399720751 0.6245596688029198 1.0 0.9818287303064076 2 Q13509 1 +Ganglion development 0.6734094616639446 0.489398399720751 0.6245596688029198 1.0 0.9818287303064076 2 Q13509 1 +Lung associated mesenchyme development 0.673409461663943 0.4893983997207454 0.6245596688029238 1.0 0.9818287303064076 2 Q13308 1 +Response to ionizing radiation 0.3446819876301904 0.4859951306085573 0.6269706183803496 1.0 0.9832420840608328 34 O75844,P09874,P46100,Q68E01 4 +Axis elongation 0.6684073107049637 0.4820898254502841 0.6297421373274605 1.0 0.984858708731272 3 Q13308,Q13263 2 +Positive regulation of cellular extravasation 0.6704730831973869 0.4803562570005007 0.630974092791645 1.0 0.9851393467271554 2 Q9BX67 1 +Fat cell differentiation 0.3490558039587036 0.479909867061597 0.6312914848017597 1.0 0.9851393467271554 21 Q8N4Q0 1 +Regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.3944325437694262 0.4798265125798587 0.6313507590106355 1.0 0.9851393467271554 11 Q9UL15,P09874,Q15233,P07237 4 +Response to dsrna 0.3585378911809824 0.4797090191200389 0.6314343138155858 1.0 0.9851393467271554 17 P41440 1 +Morphogenesis of an endothelium 0.6701468189233232 0.4793560621601248 0.6316853454682725 1.0 0.9851393467271554 2 P35222 1 +Positive regulation of pathway restricted smad protein phosphorylation 0.6701468189233124 0.4793560621600911 0.6316853454682965 1.0 0.9851393467271554 2 Q93062 1 +Regulation of pattern recognition receptor signaling pathway 0.3565307272416246 0.4786555213394831 0.6321837130870396 1.0 0.9853608409223812 18 P41440 1 +Cardiolipin metabolic process 0.4488247217809136 0.4778718227892897 0.6327414375250522 1.0 0.9854954064648872 6 Q9UJZ1,P40939 2 +Response to molecule of bacterial origin 0.3427978153396392 0.4751416573130381 0.6346860083399752 1.0 0.986509468081167 37 P08670,P17252,O43823,P30536,P14174,Q8WTV0 6 +Peptidyl proline modification 0.3429617601101958 0.4749190530955516 0.634844670492029 1.0 0.986509468081167 33 Q9Y680,O75718,P07237,Q32P28,O15460,P13674,Q9NWM8 7 +Regulation of modification of synaptic structure 0.6658787757644966 0.4748705067769578 0.6348792743260585 1.0 0.986509468081167 3 Q9UQB8 1 +Regulation of modification of postsynaptic structure 0.6658787757644966 0.4748705067769578 0.6348792743260585 1.0 0.986509468081167 3 Q9UQB8 1 +Organic acid biosynthetic process 0.299298215234561 0.4728556755015745 0.6363161496747498 1.0 0.9875416494830804 75 O94788,Q9BY49,Q13126,Q8IVS2,P34897,O95864,O14975,P28288,P09960,P14174,Q9H4L5,Q9H7Z7 12 +Regulation of genetic imprinting 0.6672104404567667 0.4703951827750613 0.638072705200353 1.0 0.9877450829502404 2 Q13263 1 +Genomic imprinting 0.6672104404567667 0.4703951827750613 0.638072705200353 1.0 0.9877450829502404 2 Q13263 1 +Positive regulation of alpha beta t cell activation 0.4198832232831843 0.4702907456737075 0.6381473083244473 1.0 0.9877450829502404 8 P00813 1 +Positive regulation of focal adhesion assembly 0.4465538172432935 0.4694066340702318 0.6387790073335187 1.0 0.9881595177015342 6 P49593,Q13464 2 +G quadruplex dna unwinding 0.5207444742399048 0.4668884307387768 0.6405797029944384 1.0 0.9881595177015342 4 Q9H2U1,P22626 2 +Receptor metabolic process 0.3417342134093778 0.4656172876765937 0.6414894663837176 1.0 0.9887132310408996 35 P42892,P41440 2 +Negative regulation of organelle organization 0.328300716341382 0.4636982603176867 0.6428639437716324 1.0 0.9893356659491488 103 P35080,Q96GD4,Q12792,Q96DY7,P09874,Q99536,Q96PK6,P30536,P53350,P46100,Q9UHB6 11 +Attachment of spindle microtubules to kinetochore 0.3490557759117521 0.4631004057191819 0.6432923992119952 1.0 0.9893356659491488 20 Q96GD4,Q9H0H5,P25054 3 +Regulation of alternative mrna splicing via spliceosome 0.3401221593290482 0.4625890714513055 0.6436589435657112 1.0 0.9893356659491488 30 Q92841,Q9BWF3,O75525,P17844,P51116,P38159,Q8IY67,P09651,Q92879,P62995,Q96T37,P98175,Q9Y2W1 13 +Protein insertion into er membrane 0.3696336191238583 0.4623648557616887 0.6438196974720314 1.0 0.9893356659491488 13 Q7L5D6,Q9NPA0,Q15629 3 +Lymphocyte costimulation 0.5192237901664964 0.4620232340845319 0.6440646589324042 1.0 0.9893356659491488 4 P98172 1 +Steroid hormone biosynthetic process 0.4244936164399918 0.4616680725592751 0.6443193702016528 1.0 0.9893356659491488 7 P30536 1 +Cellular response to chemical stress 0.3047740058696799 0.4610458202951729 0.6447657316733686 1.0 0.9893356659491488 81 P07237,P09874,Q8TDW0,Q9NR28,O95831,Q99720,P30536,P06493,Q7Z2K6,P39210 10 +Liver morphogenesis 0.6607858134724109 0.4604646138990416 0.6451827653124922 1.0 0.9893356659491488 3 Q15418 1 +Intraciliary transport 0.4438414334769942 0.4593583387254883 0.6459768604510605 1.0 0.9894970636729444 6 O43805,Q7Z4L5 2 +Regulation of telomerase activity 0.3482754115697415 0.4586726335034313 0.6464692690480727 1.0 0.9897936210416206 20 Q96GD4 1 +Nucleosome assembly 0.3404117327171234 0.457622017950095 0.6472240221191923 1.0 0.9899791473969628 33 P10412,Q01105,P07305,P25440,P46100,P84243 6 +Regulation of epithelial cell proliferation involved in lung morphogenesis 0.6626427406198898 0.4566044632039975 0.6479553706089025 1.0 0.9899791473969628 2 P60953 1 +Positive regulation of epithelial cell proliferation involved in lung morphogenesis 0.6626427406198898 0.4566044632039975 0.6479553706089025 1.0 0.9899791473969628 2 P60953 1 +Cellular response to thyroid hormone stimulus 0.6589425587467407 0.4552961538035305 0.6488961929254606 1.0 0.9908036221741088 3 Q15648,P48507 2 +Regulation of developmental growth 0.336519832999741 0.4545553236050159 0.6494291822327463 1.0 0.9908036221741088 43 P06493,P49840,P49841,O75844 4 +Long term synaptic potentiation 0.3992437712260971 0.4544335446480143 0.6495168131283298 1.0 0.9908036221741088 10 O95793,P49841,Q14168 3 +Negative regulation of cyclic nucleotide phosphodiesterase activity 0.6616639477977084 0.4536731919856344 0.6500640647789964 1.0 0.9908376074646156 2 Q15043 1 +Phosphatidylinositol 3 kinase signaling 0.4082919788459198 0.4509742670108436 0.6520080956072156 1.0 0.9908376074646156 9 O00459 1 +Detection of stimulus 0.3553312810930559 0.4506935466774089 0.6522104340911361 1.0 0.9908376074646156 15 Q8WTV0 1 +Neuron projection extension involved in neuron projection guidance 0.660358890701453 0.4497781081461202 0.6528704445548481 1.0 0.9908376074646156 2 Q13740 1 +Adipose tissue development 0.3978420464994615 0.4484706340223468 0.6538135750398446 1.0 0.9908376074646156 10 P35610 1 +Fatty acid derivative biosynthetic process 0.3552851316976984 0.447629716490134 0.6544204530141169 1.0 0.9908376074646156 14 Q9UMR5 1 +Negative regulation of telomere maintenance via telomere lengthening 0.3974758859399649 0.4469167684077711 0.6549351562819843 1.0 0.9908376074646156 10 P09651,P09874 2 +Negative regulation of binding 0.3387448671427242 0.4455075426183705 0.6559530101963835 1.0 0.9908376074646156 36 Q96GD4,P49841 2 +Regulation of adherens junction organization 0.6587275693311546 0.4449307442150156 0.6563698039114318 1.0 0.9908376074646156 2 P35611 1 +Polyadenylation dependent rna catabolic process 0.4393241063305907 0.4427791232323757 0.6579255051400235 1.0 0.9908376074646156 6 Q13868,Q06265,Q15024,Q01780 4 +Response to light stimulus 0.324539925931515 0.4426514197182715 0.658017886157789 1.0 0.9908376074646156 51 Q96GD4,Q15004,Q96RU2,P09874,P22830,Q6IQ49,P27544,Q14011 8 +Regulation of peptidase activity 0.2963607157250089 0.4424729130488114 0.6581470270473053 1.0 0.9908376074646156 75 P61604,P07948,Q9Y3B8,Q13464,Q15418,O95831,Q15392,Q9NR28,Q96HY6,Q96A26,Q92530,Q96F07,Q96K76,O15446,P49755 15 +Regulation of dna binding 0.3317672258673927 0.4409696146682378 0.6592349946254565 1.0 0.9908376074646156 24 O75844,Q96HY6 2 +Protein export from nucleus 0.3348372938206 0.4363099315671571 0.6626118770802472 1.0 0.9908376074646156 28 P12270,Q9Y3B8,P50402,P49841 4 +Mitotic recombination 0.4111372849507733 0.4351976479055672 0.6634189697197446 1.0 0.9908376074646156 8 P20585,P49959,Q92878 3 +Extracellular exosome assembly 0.6511096605744211 0.4336091253411453 0.6645723070782017 1.0 0.9908376074646156 3 Q8WUM4,Q92783 2 +Regulation of cell development 0.3009959697419473 0.4334891935689524 0.6646594151215792 1.0 0.9908376074646156 80 Q96G23,P49840,P49841,P30536,P53990 5 +Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3940167836794609 0.4323160688583016 0.6655117098713144 1.0 0.9908376074646156 10 P09874 1 +Unsaturated fatty acid biosynthetic process 0.409653247964663 0.4293237695454472 0.6676876211053082 1.0 0.9908376074646156 8 P14174 1 +Establishment of lymphocyte polarity 0.6491514360313322 0.4282587521493586 0.6684627459051631 1.0 0.9908376074646156 3 P35579,Q14254 2 +Nucleoside monophosphate metabolic process 0.3358889057430485 0.4272962170242039 0.6691635878473343 1.0 0.9908376074646156 33 P11908,P55263,P00813,P30520 4 +Tight junction organization 0.3422755078595428 0.4250033919657385 0.6708342020542535 1.0 0.9908376074646156 20 P17252,Q13464,Q16625,Q5T2T1 4 +Epithelial tube branching involved in lung morphogenesis 0.6515497553017898 0.4238911646374104 0.6716451880166301 1.0 0.9908376074646156 2 P35222 1 +Salivary gland development 0.651549755301781 0.4238911646373854 0.6716451880166483 1.0 0.9908376074646156 2 P60953 1 +Lipid modification 0.3268353443551405 0.4237930966645206 0.6717167131147188 1.0 0.9908376074646156 48 P34913,P35610,Q96N66,Q10713,Q8IVS2,Q15067,Q9BWD1,P23786,P28288,O15254,P42126 11 +Positive regulation of erad pathway 0.646540469973893 0.4211703207316408 0.673630715019182 1.0 0.9908376074646156 3 P51572,P46379 2 +Regulation of smooth muscle cell chemotaxis 0.6505709624796028 0.4210592230749557 0.6737118366323513 1.0 0.9908376074646156 2 O94813 1 +Smooth muscle cell chemotaxis 0.6505709624796028 0.4210592230749557 0.6737118366323513 1.0 0.9908376074646156 2 O94813 1 +Leukocyte apoptotic process 0.3438318191398445 0.4208244258954743 0.673883294010382 1.0 0.9908376074646156 19 Q96GD4,P14174 2 +Negative regulation of leukocyte mediated immunity 0.4324583197506662 0.4179692666967153 0.6759695876490146 1.0 0.9908376074646156 6 P04439 1 +Protein localization to endoplasmic reticulum exit site 0.5050603983023066 0.4176554666029521 0.6761990367439195 1.0 0.9908376074646156 4 O15027,P51572,Q5JRA6 3 +Cellular transition metal ion homeostasis 0.3381539337572258 0.4169458553402623 0.6767180118993577 1.0 0.9908376074646156 21 Q8N511 1 +Regulation of sterol transport 0.4063456612210692 0.4163204260277601 0.6771755478036026 1.0 0.9908376074646156 8 P30536 1 +Negative regulation of receptor mediated endocytosis 0.4318850049003622 0.4159195149914138 0.6774688989299844 1.0 0.9908376074646156 6 Q13492,P30533,Q15334,Q13614,P07355 5 +Regulation of cellular protein catabolic process 0.3002765073239424 0.4150555886814771 0.6781012097926356 1.0 0.9908376074646156 81 P49840,P49841,Q96HY6,P53350,P24941 5 +Positive regulation of mrna metabolic process 0.3014913284873866 0.414457480232016 0.6785391004483394 1.0 0.9908376074646156 60 Q13868,Q13464,P98179,Q9HCE1,Q13595,Q8N7H5,Q92945,Q6L8Q7,Q9NQT4,P19338,Q969T7,Q96E39,Q9HBH5,Q15024,Q14011,P38159,Q5PRF9,P62995,P67809,Q9Y2W1 20 +Innate immune response activating signal transduction 0.6438016553445334 0.4137912634746051 0.6790269827606736 1.0 0.9908376074646156 3 P07948 1 +Response to lectin 0.6438016553445334 0.4137912634746051 0.6790269827606736 1.0 0.9908376074646156 3 P07948 1 +Mrna modification 0.379177715804367 0.4127476680027694 0.6797914965011329 1.0 0.9908376074646156 11 Q96FX7,Q99729,Q96PZ0,Q9Y606 4 +Gmp metabolic process 0.3467767178568882 0.4120667071837562 0.6802905301654996 1.0 0.9908376074646156 16 P55263,O14936,P00813 3 +Positive regulation of neural precursor cell proliferation 0.4306218733790602 0.4114157228431255 0.6807677268804593 1.0 0.9908376074646156 6 P35222,P07948,P04899,O60341 4 +Amino acid transmembrane transport 0.3463380407331732 0.4098706727052219 0.6819008198199759 1.0 0.9908376074646156 16 Q9Y619,Q8TDW0,Q8IWT6,P30825,Q15758 5 +Inositol lipid mediated signaling 0.3783700918582296 0.4092811780716592 0.6823333266129472 1.0 0.9908376074646156 11 O00459 1 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.6463295269167958 0.408892519791534 0.6826185387139196 1.0 0.9908376074646156 2 P51572 1 +Fluid transport 0.6460032626427272 0.4079637546637822 0.6833002851062688 1.0 0.9908376074646156 2 Q99797 1 +Positive regulation of neuroblast proliferation 0.6456769983686741 0.4070360169800796 0.6839815352543741 1.0 0.9908376074646156 2 P35222 1 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.4103705042368938 0.4070276715068899 0.6839876646150189 1.0 0.9908376074646156 7 Q96CV9 1 +Response to mitochondrial depolarisation 0.4103705042368938 0.4070276715068899 0.6839876646150189 1.0 0.9908376074646156 7 Q96CV9 1 +Regulation of response to dna damage stimulus 0.2950800054303476 0.4068148648764079 0.6841439681887596 1.0 0.9908376074646156 77 P61978,Q9NY27,Q9NV56,P09874,Q7Z4V5,Q96K76,Q9NYB0,P35637,P14174,Q9NPF5,O75844,Q9UBU8 12 +Positive regulation of protein catabolic process 0.2951091566703863 0.4065541848378622 0.6843354525695693 1.0 0.9908376074646156 62 P53350,Q96HY6,P49840,P49841 4 +Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus 0.6450244698205456 0.4051836304260054 0.6853425366790507 1.0 0.9908376074646156 2 Q9NXV6 1 +Cellular response to insulin stimulus 0.3181431701362648 0.4047997014411751 0.6856247482715601 1.0 0.9908376074646156 52 P09874,P49840,P49841,O00459 4 +Negative regulation of receptor binding 0.6446982055464856 0.4042589847916018 0.6860222828940823 1.0 0.9908376074646156 2 P16615 1 +Intraciliary transport involved in cilium assembly 0.6443719412724236 0.4033353730730015 0.6867015227419544 1.0 0.9908376074646156 2 Q15154 1 +Negative regulation of cysteine type endopeptidase activity 0.3382734394255132 0.4029318018197242 0.6869983954211096 1.0 0.9908376074646156 20 Q9Y3B8,Q15418,Q15392,Q96K76,O15446 5 +Regulation of cell cell adhesion 0.3240371573394086 0.4021037623574781 0.6876076639800175 1.0 0.9908376074646156 48 P07948,P00813,P04439,P17252,P30825,P41440,P98172 7 +Hormone biosynthetic process 0.3961811919233258 0.4020695300790728 0.6876328563412724 1.0 0.9908376074646156 9 P30536 1 +Rna 5 end processing 0.3766250102069165 0.401821916107477 0.6878150917726948 1.0 0.9908376074646156 11 O15091 1 +Nuclear ncrna surveillance 0.4470698206563194 0.4011024630477466 0.6883446875167858 1.0 0.9908376074646156 5 Q13868,Q15024,Q01780 3 +Negative regulation of rna catabolic process 0.331550733006836 0.4007347613423664 0.6886154150227832 1.0 0.9908376074646156 32 Q92615,P07910,Q9H7Z3,Q92804,Q99729,P35637,Q13151,Q14011,P67809,P98175,Q9Y2W1 11 +Protein hexamerization 0.4268329438778705 0.3980085720603503 0.6906238670500322 1.0 0.9908376074646156 6 Q8TDW0 1 +Ear development 0.3345570249300357 0.3966875681688166 0.6915978687920212 1.0 0.9908376074646156 21 P42892,P54802 2 +Regulation of mitotic cell cycle 0.3355931594225864 0.3964821445252999 0.6917493775258352 1.0 0.9908376074646156 117 Q96GD4,Q9Y619,Q14004,P49454,Q96DY7,P53350,P06493,P24941,P21127,Q68E01,O75844 11 +Mitochondrial genome maintenance 0.3945377697390111 0.3955670100526121 0.6924244782523381 1.0 0.9908376074646156 9 P09874 1 +Ribose phosphate biosynthetic process 0.2960944021514468 0.3948794270098714 0.6929318736345231 1.0 0.9908376074646156 79 P00846,P30520,P35610,P09874,P11908,P33121,P55263,Q9UMR5 8 +Alcohol biosynthetic process 0.3307194487366472 0.3932250825024196 0.6941532456426143 1.0 0.9908376074646156 33 Q15392,P37268,Q16850,Q14739,Q15126 5 +Developmental cell growth 0.3302092439159626 0.3914691945643757 0.6954504546986982 1.0 0.9908376074646156 39 P53990,P49840,P49841 3 +Positive regulation of amyloid beta clearance 0.6349993424346561 0.3904765590805334 0.6961841855166127 1.0 0.9908376074646156 3 Q13464 1 +Cellular response to abiotic stimulus 0.2810554035612415 0.3893433070904005 0.69702220417865 1.0 0.9908376074646156 66 Q96GD4,P30520,Q96RU2,Q8TDW0,P09874,P27544,P30536,O75844 8 +Mitochondrial trna processing 0.4434676150849957 0.3892860692826263 0.6970645402866578 1.0 0.9908376074646156 5 O15091 1 +Positive regulation of cysteine type endopeptidase activity 0.3243473898432752 0.3881981613984331 0.6978693936857794 1.0 0.9908376074646156 25 Q9NR28,O95831,Q96F07 3 +Regulation of atp biosynthetic process 0.4429387331171178 0.3875627714592435 0.6983396236651487 1.0 0.9908376074646156 5 P09874 1 +Nadh dehydrogenase complex assembly 0.3268957115569275 0.3861173858328597 0.6994097343699375 1.0 0.9908376074646156 28 Q8N183,P03915,O43676 3 +Insulin secretion involved in cellular response to glucose stimulus 0.4047735958787132 0.3859816259950619 0.6995102767129573 1.0 0.9908376074646156 7 Q8N183 1 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.4047735958787132 0.3859816259950619 0.6995102767129573 1.0 0.9908376074646156 7 Q8N183 1 +Positive regulation of protein targeting to membrane 0.4233019546749794 0.3856559356366193 0.6997515011289872 1.0 0.9908376074646156 6 Q9GZY8,Q9NQG6,P27105 3 +Hematopoietic progenitor cell differentiation 0.3246081213461358 0.3832738435594223 0.7015167310447763 1.0 0.9908376074646156 26 Q9NPH0 1 +Positive regulation of atp dependent activity 0.3344413027344051 0.3821053423210261 0.7023832293474457 1.0 0.9908376074646156 20 P35080,Q8IXB1 2 +Nucleoside triphosphate biosynthetic process 0.3289715590712839 0.3818561381578246 0.7025680759850261 1.0 0.9908376074646156 33 P55263,P00846 2 +Regulation of receptor binding 0.6314550088423794 0.3812656838187603 0.7030061143848254 1.0 0.9908376074646156 3 P16615 1 +Ameboidal type cell migration 0.2846453545606355 0.3800316960295932 0.7039218870846828 1.0 0.9908376074646156 70 P35080,Q14185,Q13685,P60953,P06576,Q13464,P42785,P17252,Q9NPQ8,P08133,P09601,Q8WTV0,P98172 13 +Embryonic morphogenesis 0.2801289674628354 0.3799724162760944 0.7039658908712525 1.0 0.9908376074646156 66 O94788,P67809,P25440,P54802,P07942,P42892 6 +Adherens junction assembly 0.4405617243631716 0.3798548425586471 0.7040531696180796 1.0 0.9908376074646156 5 Q13177,P35222,Q9BX67,Q9BTW9 4 +Regulation of cysteine type endopeptidase activity 0.3244355319668421 0.3789337900854704 0.7047370312483505 1.0 0.9908376074646156 45 P61604,Q9Y3B8,Q15418,Q15392,O95831,Q9NR28,Q96A26,Q96F07,Q96K76,O15446 10 +Regulation of myoblast differentiation 0.6305170388723833 0.3788454899137223 0.7048026047725582 1.0 0.9908376074646156 3 Q8IWT6 1 +Regulation of rna export from nucleus 0.3809423354405459 0.3784909567115808 0.705065910503438 1.0 0.9908376074646156 10 P12270,Q9H7Z3,Q08J23,Q16630 4 +Negative regulation of transferase activity 0.2861843723961196 0.3775794808559656 0.7057430101222399 1.0 0.9908376074646156 64 P49840,P27544,Q9Y3B8,P49841 4 +Antigen processing and presentation of exogenous peptide antigen 0.6291851337139374 0.3754214456105678 0.7073470580362042 1.0 0.9908376074646156 3 P04439 1 +Cellular response to cold 0.6291487715565496 0.3753281743296701 0.7074164150840598 1.0 0.9908376074646156 3 Q13217 1 +Regulation of intracellular steroid hormone receptor signaling pathway 0.320722424149072 0.3734173375250436 0.7088378577247922 1.0 0.9908376074646156 24 Q96HY6 1 +Camera type eye development 0.3253371337337171 0.3716605092204639 0.710145631123609 1.0 0.9908376074646156 29 P08670,O94788,Q99797,P54802,Q16706,Q15293 6 +Vascular associated smooth muscle contraction 0.6323001631321306 0.3699031471604829 0.7114546564170128 1.0 0.9908376074646156 2 P20020 1 +Mesonephros development 0.4889681150136692 0.3694734300160325 0.7117748741288619 1.0 0.9908376074646156 4 P35222,P80723 2 +Positive regulation of protein k63 linked ubiquitination 0.6319738988580659 0.3690199994175695 0.7121128178223435 1.0 0.9908376074646156 2 P61088 1 +Nucleus organization 0.2821665958820853 0.3684350304022459 0.7125488811699543 1.0 0.9908376074646156 65 O75151,Q14978,Q9BTX1,Q8WYP5,P12270,Q9BTV4,P17252,Q86XL3,P53350,P06493,P50402,O75844 12 +Bile acid metabolic process 0.3683182065264123 0.3669175511532636 0.7136805192443121 1.0 0.9908376074646156 11 Q9H4L5,O15118,P28288 3 +Negative regulation of macroautophagy 0.3775191110723246 0.364778089084021 0.7152770621319364 1.0 0.9908376074646156 10 O15118,P09601 2 +Neuron projection arborization 0.4168567755463973 0.3634743755193507 0.7162505512910531 1.0 0.9908376074646156 6 Q9HCE1,Q13464 2 +T cell differentiation in thymus 0.3924663315871974 0.3631647797877532 0.7164817957560428 1.0 0.9908376074646156 8 P00813 1 +Branching involved in blood vessel morphogenesis 0.4856181857219325 0.3597633012676594 0.7190241494367564 1.0 0.9908376074646156 4 Q96T37 1 +Protein import 0.3021787087103805 0.3587093135877606 0.7198125602454857 1.0 0.9908376074646156 88 Q14978,Q9NS69,Q99595,O00459,O75381,O95831,P06493,O60830 8 +Regulation of receptor mediated endocytosis 0.3298340693089253 0.3574866925548537 0.7207274867361972 1.0 0.9908376074646156 20 P41440 1 +Mitotic cell cycle phase transition 0.3203569723273763 0.3539815442386854 0.7233527144854772 1.0 0.9908376074646156 106 Q96GD4,Q9Y619,P49454,Q96DY7,P08183,P53350,P06493,P24941,Q68E01 9 +Nucleoside catabolic process 0.4832009795911281 0.3528282573666312 0.7242171981258378 1.0 0.9908376074646156 4 Q13126 1 +Positive regulation of blood vessel endothelial cell migration 0.3744757627617358 0.3527276955954846 0.7242925941597957 1.0 0.9908376074646156 10 P17252,P06576 2 +Sulfur compound biosynthetic process 0.3231661690513377 0.3527201894989634 0.7242982219514404 1.0 0.9908376074646156 42 Q13126,Q9UMR5,P35610 3 +Insulin processing 0.6182155735299666 0.3477946338460841 0.7279944199539619 1.0 0.9908376074646156 3 Q8TAD4 1 +Cell surface receptor signaling pathway involved in cell cell signaling 0.2802563893369199 0.3473980554666847 0.7282922939997172 1.0 0.9908376074646156 69 Q14696,Q96C57,Q9H2V7,P49840,P49841,Q99808,Q14168,Q9UQB8,P20339,P25054,Q96K76,P50402 12 +Mitochondrial fragmentation involved in apoptotic process 0.4299114421115704 0.3460917684878534 0.7292737494195884 1.0 0.9908376074646156 5 Q9GZY8 1 +Regulation of platelet derived growth factor receptor signaling pathway 0.6174934725848612 0.3460125910576357 0.7293332522497864 1.0 0.9908376074646156 3 Q07954,O00291 2 +Dsrna processing 0.3331905169951135 0.345770840098488 0.7295149412086128 1.0 0.9908376074646156 16 O75569,Q08209,P17844,Q15631,Q9BXP5,P22626,O75844 7 +Negative regulation of immune response 0.3271988759626256 0.3436212999207721 0.7311311040703585 1.0 0.9908376074646156 20 P04439,P07948,P28070 3 +Myoblast differentiation 0.3871474682951096 0.3434400203733176 0.7312674564129416 1.0 0.9908376074646156 8 P17844,Q8IWT6,Q15149,Q92841 4 +Bile acid biosynthetic process 0.3809099689115683 0.3429894017220488 0.7316064332880952 1.0 0.9908376074646156 9 Q9H4L5,P28288 2 +Mitochondrial rna processing 0.386563540048687 0.3412976119111361 0.7328795455221153 1.0 0.9908376074646156 8 O15091 1 +Synaptic signaling 0.301360250664757 0.3402693409945657 0.7336537034301416 1.0 0.9908376074646156 89 Q4J6C6,Q9NR77,P49840,P49841,P41440 5 +Protein dna complex disassembly 0.3323776126085228 0.3395031120900656 0.7342307530495167 1.0 0.9908376074646156 14 O14497,Q969G3,Q01105 3 +Gliogenesis 0.3142342446632887 0.3375754876936738 0.7356831168605069 1.0 0.9908376074646156 49 Q96G23,Q96N66,P30536,P06493,P07942 5 +Positive regulation of ion transport 0.3224999806834114 0.3367722953970754 0.7362885594024768 1.0 0.9908376074646156 37 P08183,P14174 2 +Transcription coupled nucleotide excision repair 0.4773098269670091 0.3361828904666779 0.7367329542594043 1.0 0.9908376074646156 4 P19447,Q93009,Q9HCS7 3 +Establishment of tissue polarity 0.3908407200422933 0.335246307902194 0.7374392924523936 1.0 0.9912215969940268 7 Q8TAA9,Q92796 2 +Positive regulation of endothelial cell development 0.6182707993474623 0.3329350442943721 0.7391833155179077 1.0 0.9917051264016584 2 P35611 1 +Chromatin disassembly 0.3305210655174625 0.3311816860950437 0.7405072527843413 1.0 0.9919858193106494 14 O14497,Q969G3,Q01105 3 +Negative regulation of platelet derived growth factor receptor signaling pathway 0.6172920065252763 0.3304343404258342 0.7410717974344296 1.0 0.9919858193106494 2 Q07954 1 +L serine transport 0.6110579665172791 0.3303352339436531 0.741146672912617 1.0 0.9919858193106494 3 Q15758 1 +Body fluid secretion 0.3302836836497586 0.3301228827813661 0.741307113605636 1.0 0.9919858193106494 14 Q99808 1 +Fatty acyl coa metabolic process 0.3298222901912197 0.3281362784099428 0.7428086249977484 1.0 0.9919858193106494 15 Q9UMR5 1 +Mitochondrial calcium ion homeostasis 0.3586135906919482 0.3274847370192241 0.7433012852007737 1.0 0.9919858193106494 11 Q9Y4W6,P08133 2 +Positive regulation of mitotic cell cycle 0.3200085636204376 0.3272572908551509 0.74347329239864 1.0 0.9919858193106494 41 P06493 1 +G protein coupled receptor signaling pathway 0.3180913700161831 0.3270177101687042 0.7436544902305946 1.0 0.9919858193106494 44 Q9UBI6,P49840,Q99720,P42892 4 +Inositol phosphate catabolic process 0.473730779754337 0.3262518645712478 0.7442338038934211 1.0 0.9919858193106494 4 Q10713 1 +Canonical wnt signaling pathway 0.3203423325609653 0.3235471651591491 0.7462808939710146 1.0 0.9919858193106494 35 P20339,P49840,P50402,P49841 4 +Granulocyte differentiation 0.3874978601896159 0.323448249550412 0.7463557937030783 1.0 0.9919858193106494 7 Q14739 1 +Apical junction assembly 0.315540818746727 0.323380845495039 0.7464068339944268 1.0 0.9919858193106494 23 P17252,Q13464,Q16625,Q5T2T1 4 +Cell junction maintenance 0.4222730241672021 0.322691350081781 0.7469290036335832 1.0 0.9919858193106494 5 Q96AC1,Q14203,Q15334,P56545 4 +Dna double strand break processing 0.4222179369149131 0.3225251583123558 0.7470548816057199 1.0 0.9919858193106494 5 P61088,P49959,P51530 3 +Regulation of stem cell population maintenance 0.4216198563030743 0.3207232274062072 0.7484201435092159 1.0 0.9925371896559824 5 Q15061,Q9Y6J9,Q15717,Q9NZN8 4 +G protein coupled acetylcholine receptor signaling pathway 0.6130505709624701 0.3197190808433209 0.7491812939940221 1.0 0.9925371896559824 2 P04899 1 +Nuclear transcribed mrna catabolic process exonucleolytic 0.3379488570304239 0.3191022861292247 0.7496489501390804 1.0 0.9925371896559824 13 Q13868,Q9NQT4,Q969T7,Q15024 4 +Cellular response to steroid hormone stimulus 0.3101870084273261 0.3174343211612351 0.7509140682522755 1.0 0.9925371896559824 50 O15118,P09874,O95831,Q96HY6,O15173 5 +Cenp a containing chromatin organization 0.6117455138662228 0.3164619783749233 0.7516518801789387 1.0 0.9925371896559824 2 Q6IPU0 1 +Nuclear transcribed mrna catabolic process exonucleolytic 3 5 0.3791504980061259 0.3145108428207865 0.7531330826012459 1.0 0.9929333753444692 8 Q13868,Q9NQT4,Q15024 3 +Dna ligation involved in dna repair 0.6091353996737257 0.310004624789056 0.756557439425114 1.0 0.9941398350891788 2 Q96T60 1 +Hydrogen peroxide biosynthetic process 0.6022928967207503 0.309586926076949 0.7568750996440898 1.0 0.9941398350891788 3 Q15067 1 +Regulation of integrin activation 0.6081566068515398 0.3076027647430068 0.7583846161921279 1.0 0.9941398350891788 2 Q9BX67 1 +Regulation of lipid biosynthetic process 0.3105559985249293 0.3066640351109803 0.7590991073752453 1.0 0.9941398350891788 25 Q8WTV0 1 +Regulation of retrograde transport endosome to golgi 0.607177814029354 0.305211674057046 0.760204941735819 1.0 0.9949764043894368 2 P53367 1 +Middle ear morphogenesis 0.600223301302843 0.3047917146868072 0.7605247922018665 1.0 0.9951912258317216 3 P54802 1 +Notch signaling pathway 0.3522122093752832 0.302328423088616 0.7624017130056107 1.0 0.9955033608069112 11 P09525,Q96T37 2 +Positive regulation of epithelial cell migration 0.3138108922027501 0.3018070811310044 0.7627991324860588 1.0 0.9955033608069112 29 Q14185,Q13685,P06576,P17252,Q8WTV0 5 +Negative regulation of mononuclear cell migration 0.6048939641109198 0.2996745290984187 0.7644254290106789 1.0 0.9955490554947836 2 O94813 1 +Gmp biosynthetic process 0.3426711465180762 0.2995234800348246 0.7645406594073241 1.0 0.9955490554947836 12 P55263 1 +Regulation of neuron projection arborization 0.5975639567444222 0.2986892326552951 0.7651771733298112 1.0 0.9955490554947836 3 Q9HCE1 1 +Regulation of myeloid leukocyte differentiation 0.3603102210653829 0.2984916777447248 0.7653279269861764 1.0 0.9955490554947836 10 P17252,Q9BRX8 2 +Metaphase anaphase transition of cell cycle 0.3123020214278528 0.2980994949877651 0.7656272269999784 1.0 0.9955490554947836 28 P12270,Q96GD4,P53350,P49454 4 +Mitochondrial gene expression 0.2951521273946695 0.2963874384102588 0.7669342173111029 1.0 0.9958302687597032 57 Q8NC60,Q9HD33,P82914,O15091,Q6P087,Q567V2,P82673,Q9BRT2,P34897,Q9Y606,Q92552,Q9NSE4,Q96EY7,Q9NX20,Q5JTZ9 15 +Tissue remodeling 0.3207297706636444 0.2951850673839125 0.7678525085374286 1.0 0.99641530600258 18 O14773,Q92791,P17252 3 +Cellular copper ion homeostasis 0.461312438785501 0.292898443235984 0.7695997788173872 1.0 0.997430268851134 4 P35670,O60826,O75880 3 +Positive regulation of mitochondrial fission 0.3783671702741656 0.2920144672171467 0.770275562590581 1.0 0.9979386013615252 7 Q9GZY8,Q9NQG6 2 +Calcium import into the mitochondrion 0.37247051051927 0.2910518721417834 0.7710116476326909 1.0 0.9980660883742604 8 Q8WWC4,Q9Y4W6 2 +Long chain fatty acyl coa metabolic process 0.3659161339326338 0.2881692661656725 0.7732171734075386 1.0 0.9980660883742604 9 P33121 1 +Receptor localization to synapse 0.3395232648619898 0.2870429798949199 0.7740794110941298 1.0 0.9980660883742604 12 Q14168,P57105,O15400,Q92796 4 +Regulation of mitochondrial dna replication 0.5917101827676242 0.2854936026116275 0.7752660049367477 1.0 0.9980660883742604 3 Q9UJZ1,P49916 2 +Regulation of dna helicase activity 0.5917101827676213 0.2854936026116208 0.7752660049367528 1.0 0.9980660883742604 3 P49736,P33993 2 +T cell proliferation 0.3086273317055635 0.2853938146687877 0.7753424457649789 1.0 0.9980660883742604 23 P04439,P30825,P98172 3 +Forebrain development 0.3043188549072756 0.2841553687110791 0.776291316822372 1.0 0.9980660883742604 51 Q96N66,O94788,O15511,P49841,P46100 5 +Cellular response to organic cyclic compound 0.3160726023604546 0.2841331698557653 0.7763083281659284 1.0 0.9980660883742604 109 P49840,P09874,P49841,O95831,Q96HY6,P41440,P53985 7 +Somatic stem cell population maintenance 0.5977161500815572 0.2826594988195956 0.7774378658436021 1.0 0.99833796751244 2 Q9Y6J9 1 +Positive regulation of hematopoietic progenitor cell differentiation 0.5973898858074934 0.281900185912123 0.7780200469774141 1.0 0.99833796751244 2 Q9H2U1 1 +Iron ion homeostasis 0.3176697730106605 0.2769149277339114 0.7818454299826296 1.0 1.0 17 Q8N511 1 +Negative regulation of homotypic cell cell adhesion 0.5938009787928112 0.2736294605411235 0.7843693915131575 1.0 1.0 2 P35241 1 +Protein n linked glycosylation 0.3169108718753229 0.271527790838747 0.7859851282695751 1.0 1.0 16 P04843,Q8TCJ2,O95394,Q9H0U3,P04844,P39656,Q2TAA5,Q9NYU2,Q96AA3,P46977,Q9BT22 11 +Pre mirna processing 0.5851805325128906 0.2711653873694947 0.7862638328317095 1.0 1.0 3 O75569 1 +Mirna loading onto risc involved in gene silencing by mirna 0.5851805325128906 0.2711653873694947 0.7862638328317095 1.0 1.0 3 O75569 1 +Regulation of epithelial to mesenchymal transition 0.3877817706631812 0.2698869766479272 0.7872472066572664 1.0 1.0 6 Q92769,P35222,Q14118,Q96AC1,Q7Z460 5 +Maintenance of dna methylation 0.4521710741103441 0.2694865858914092 0.7875552634391421 1.0 1.0 4 Q9NRZ9,Q96T88,Q93009 3 +Cellular response to light stimulus 0.3090550609688338 0.2694075977307244 0.7876160400944177 1.0 1.0 30 Q96GD4,Q96RU2,P09874,Q6IQ49,P27544 5 +Regulation of canonical wnt signaling pathway 0.3110701147770477 0.2679223334970519 0.7887591023175395 1.0 1.0 34 P49840 1 +Signal release 0.2872989746643863 0.2677769853048796 0.7888709870442736 1.0 1.0 59 P35080,Q4J6C6,Q8N183,O15439,P49841,P20339,P14174,P53985 8 +Transcription elongation from rna polymerase ii promoter 0.3020819087132401 0.2665566294341905 0.7898105523529511 1.0 1.0 24 Q14004 1 +Tangential migration from the subventricular zone to the olfactory bulb 0.5902120717781291 0.265509492109125 0.7906169985413687 1.0 1.0 2 O94813 1 +Response to insulin 0.279688765293729 0.2653101087203784 0.7907705778362395 1.0 1.0 62 P09874,P49840,P49841,O00459 4 +Vitamin d receptor signaling pathway 0.5823742277991111 0.2651360044760748 0.7909046919772982 1.0 1.0 3 O15164 1 +Regulation of vitamin d receptor signaling pathway 0.5823742277991111 0.2651360044760748 0.7909046919772982 1.0 1.0 3 O15164 1 +Regulation of golgi organization 0.3587779188849584 0.2632968787551568 0.792321765236063 1.0 1.0 9 Q9Y4I1 1 +Negative regulation of peptidase activity 0.3103863098877202 0.2619119708660387 0.7933893102815006 1.0 1.0 35 Q9Y3B8,Q15418,Q13464,Q15392,Q92530,Q96K76,O15446,P49755 8 +Carbohydrate homeostasis 0.308487859075112 0.2611829230666786 0.7939514466063986 1.0 1.0 44 Q99808,Q8N183,P42785,P53985 4 +Transition metal ion homeostasis 0.3034676948626453 0.2600365531155861 0.7948355778729215 1.0 1.0 26 Q8TAD4,Q8N511 2 +Membrane biogenesis 0.3085937731444769 0.259499495118095 0.7952498715198213 1.0 1.0 21 P41440 1 +Vesicle targeting 0.3081233696552836 0.2571781760573946 0.7970412305125079 1.0 1.0 21 P49755,O95772,Q8N6H7,O95721 4 +Peptidyl lysine modification 0.2965895883560951 0.2547785801390582 0.7988941200151964 1.0 1.0 93 P10412,Q92791,Q9NV56,Q9BU89,Q9UBU8,O75844,Q9H3P2,P46100 8 +Small molecule catabolic process 0.3196836681673674 0.2535015512041199 0.7998806626192472 1.0 1.0 116 Q9NX62,P85037,Q13126,P49840,Q15067,P30837,P23786,Q8WTV0,O15254,P42126,Q8NCC3,Q8IVS2,O75600,Q9BQT8,P00813,P28288,O14874,P35610,Q10713,Q9BWD1 20 +Organelle fusion 0.3072749386496393 0.2531103950851066 0.800182906258625 1.0 1.0 44 Q9Y4W6,O15400,Q9Y6C9,Q9GZY8,Q9NX63,Q86Y82,O95249,P56962,Q8IWA4,Q99536,Q969M3,P06493 12 +Plasma membrane to endosome transport 0.4440617705498176 0.2495621836318612 0.8029259464146012 1.0 1.0 4 P61020,P51148 2 +Transcytosis 0.3595951661222087 0.2477759306551389 0.8043077788766324 1.0 1.0 8 P20339,P55899 2 +Negative regulation of secretion 0.3061851182491286 0.2476813649646772 0.804380951301146 1.0 1.0 21 Q8N5M9,Q16836,Q8N183,P00813,Q16850 5 +Intrinsic apoptotic signaling pathway in response to oxidative stress 0.3110761402361701 0.2464645309709159 0.8053226578871104 1.0 1.0 16 P09874,Q15233,Q9NR28,P07237 4 +Regulation of extent of cell growth 0.3075593695950494 0.2457595278157213 0.8058683884288609 1.0 1.0 20 P49841 1 +Cytosolic transport 0.2748078916132058 0.2455365219095324 0.8060410330771002 1.0 1.0 63 Q8N1B4,Q4J6C6,O95249,O75494,Q96JG6,P51151,A4D1P6,P20339,O14976,O15260 10 +Establishment of epithelial cell polarity 0.3786607755482768 0.2429377189017233 0.8080536452254574 1.0 1.0 6 Q13308,P60953 2 +Negative regulation of transcription by rna polymerase ii 0.3318838863692586 0.2429229619774972 0.808065077191656 1.0 1.0 130 Q9H0E3,P10412,P85037,P18615,Q00577,P41440,P24941,P98175,P45973,P78318,Q9H1B7,Q9UBK9,P46100,Q12873,Q96GD4,P12270,P23246,Q13185,Q8WXI9,P82979,P53350,Q9NPF5,P22626,Q96MG7,O95104,Q96EY1,P09874,Q8N6R0,O75446,P16403,Q8NB78,P67809 32 +Glucosylceramide metabolic process 0.5797716150081456 0.242756506440915 0.8081940306181465 1.0 1.0 2 Q05655 1 +Astral microtubule organization 0.4407443682664098 0.2416462301425575 0.8090542969490271 1.0 1.0 4 P15311,Q7Z460,Q14980 3 +Respiratory system development 0.2973418212042814 0.2410353807093268 0.8095276949349341 1.0 1.0 24 O94788,P60953,P00813,P09960,Q15750,Q16706,P80723 7 +Base excision repair 0.309711932318625 0.2407303419079772 0.8097641209563919 1.0 1.0 16 Q96K76,P78549 2 +Regulation of sprouting angiogenesis 0.4400938581535223 0.2401102077802431 0.8102448210009898 1.0 1.0 4 Q9Y6I3 1 +Positive regulation of actin cytoskeleton reorganization 0.4397615707454095 0.2393276532374971 0.8108515241732563 1.0 1.0 4 Q9UQB8 1 +Negative regulation of translational elongation 0.5771615008156484 0.2372725559112607 0.8124453514545589 1.0 1.0 2 P38919 1 +Mitochondrion morphogenesis 0.3430740790356618 0.2370188019230812 0.812642203981758 1.0 1.0 10 Q8TCS8,Q04837,Q15149,Q8IYB8,Q9Y2S7,Q7Z406,Q9GZY8 7 +Positive regulation of transmembrane transport 0.3014361742369135 0.2366746226119223 0.8129092238944733 1.0 1.0 28 P33121,P08183 2 +Chondrocyte differentiation 0.3502853306167094 0.2348139385949035 0.8143531487491289 1.0 1.0 9 P08133 1 +Embryonic skeletal system morphogenesis 0.4365001632386551 0.2317212023672839 0.8167545624366641 1.0 1.0 4 P35222,P38919,Q6UB35 3 +Embryonic skeletal system development 0.4365001632386551 0.2317212023672839 0.8167545624366641 1.0 1.0 4 P35222,P38919,Q6UB35 3 +Mammary gland epithelium development 0.3747141457040215 0.2316633742451393 0.81679948064254 1.0 1.0 6 Q99623,P28482,Q92766,Q14160,Q15648 5 +Cellular response to peptide hormone stimulus 0.2705156244697428 0.2314964194862917 0.8169291667396046 1.0 1.0 64 P09874,P49840,P49841,O00459 4 +Regulation of autophagy 0.2960485699396215 0.2306619239056096 0.817577456187462 1.0 1.0 95 P85037,Q96CV9,O00459,P21796,O15118,P49840,Q9Y5K8,P49841,Q93050,P17252,Q9UPT5,P27544,P30536,O75844,P36543 15 +Embryo implantation 0.3320758791286831 0.2280883220113453 0.8195775785208077 1.0 1.0 11 P47914,Q07021,Q9H9Y6,P84243 4 +Establishment or maintenance of cytoskeleton polarity 0.4345412993796906 0.2272178571907786 0.8202543427799522 1.0 1.0 4 Q99661,P02545,O00151 3 +Negative regulation of response to endoplasmic reticulum stress 0.3317269786503957 0.226871857625556 0.8205233858497241 1.0 1.0 11 Q96HY6 1 +Regulation of chromatin binding 0.5632147478722909 0.2260879129697511 0.8211330452735266 1.0 1.0 3 Q08209 1 +Ribonucleoside triphosphate biosynthetic process 0.2983411291780081 0.2258096531589245 0.8213494688450131 1.0 1.0 27 P09874,P00846 2 +Progesterone receptor signaling pathway 0.5626631853785853 0.2250193885787941 0.8219641911138964 1.0 1.0 3 O95071,Q969T9 2 +Negative regulation of hormone secretion 0.3523786084785552 0.224706046764798 0.8222079602648353 1.0 1.0 8 Q8N183,Q16836 2 +Negative regulation of peptide secretion 0.3523786084785552 0.224706046764798 0.8222079602648353 1.0 1.0 8 Q8N183,Q16836 2 +Ruffle organization 0.3049126459370656 0.2243307280434957 0.8224999679079872 1.0 1.0 14 Q9UHB6 1 +Regulation of axonogenesis 0.2992979635149789 0.2242709278083989 0.82254649630473 1.0 1.0 22 P49841 1 +Type i interferon production 0.2938144456536147 0.2225236678805369 0.8239062507867283 1.0 1.0 24 P41440 1 +Hydrogen peroxide metabolic process 0.3462266524406869 0.2216457061275799 0.8245896989709793 1.0 1.0 9 Q15067,Q13162 2 +Maintenance of protein location in cell 0.304385921514183 0.2212828004097341 0.8248722413361294 1.0 1.0 18 P30536 1 +Cell migration involved in gastrulation 0.5600135793753446 0.2199303887050198 0.8259253689185024 1.0 1.0 3 Q9NPQ8 1 +Positive regulation of cell cycle checkpoint 0.3849271865775888 0.2192067076288495 0.8264890306167467 1.0 1.0 5 P12270 1 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.5667210440456647 0.2161645150547233 0.8288595125083085 1.0 1.0 2 P23396 1 +Protein demethylation 0.3443686182604608 0.2157160268384721 0.8292091077197798 1.0 1.0 9 Q8NB78 1 +Protein localization to presynapse 0.4291741745644124 0.215132545118818 0.8296639805768016 1.0 1.0 4 Q14168 1 +Axo dendritic protein transport 0.4291741745644124 0.215132545118818 0.8296639805768016 1.0 1.0 4 Q14168 1 +Regulation of secretion 0.2889783977484925 0.2139350643834399 0.8305976957663241 1.0 1.0 90 P35080,Q4J6C6,Q8N183,P00813,P49841,Q32P28,Q16850,P51151,P20339,P14174,P53985,P49755 12 +Cardiac septum development 0.3360570306565008 0.2135506688997299 0.8308974723760567 1.0 1.0 10 Q13308,O94813,Q15750,O96028,Q96T37 5 +Positive regulation of translational initiation 0.3347167280402209 0.2091763470051331 0.8343105763437602 1.0 1.0 10 Q13217 1 +Regulation of nucleobase containing compound transport 0.3264702249066228 0.2088487231760953 0.834566334324788 1.0 1.0 11 P12270,Q9H7Z3,Q08J23,Q16630 4 +Substrate adhesion dependent cell spreading 0.3013764225992446 0.2084750101413319 0.8348580929897442 1.0 1.0 18 Q14185,P60953,P07237,Q92766,P07942 5 +Regulation of release of cytochrome c from mitochondria 0.3260468085515898 0.2074221981219292 0.8356801479622109 1.0 1.0 11 Q96A26 1 +Negative regulation of cytokine production 0.2919857170165146 0.2057833460363266 0.8369601507251327 1.0 1.0 25 P09525,P09601,O43823,P30536 4 +Regulation of mitochondrial membrane potential 0.301080993325907 0.2056327977110325 0.8370777561156306 1.0 1.0 17 P09874,Q8IWA4,P30536 3 +U4 snrna 3 end processing 0.3635823360247282 0.2011714993044109 0.8405644761691995 1.0 1.0 6 Q9NQT4,Q15024 2 +Protein acetylation 0.293689360893156 0.1986676269269754 0.8425227491746785 1.0 1.0 50 Q9NV56,Q9NYB0,P49841,Q9UBU8,Q9NPF5,O75844,Q5VZE5 7 +Mitochondrial calcium ion transmembrane transport 0.3231964519820329 0.1979184506270599 0.8431088682074168 1.0 1.0 11 Q8WWC4,Q9Y4W6 2 +Dorsal ventral pattern formation 0.3759947635544811 0.1973857167785183 0.8435257061070267 1.0 1.0 5 P17252 1 +Reactive oxygen species metabolic process 0.2994135148682578 0.1967344182855492 0.8440353745216831 1.0 1.0 42 Q13423,Q15067,P42785,Q9BTZ2,P30536,Q9UII2,P39210,Q13162 8 +Positive regulation of dna metabolic process 0.2848979460150898 0.196278994098959 0.8443918018812555 1.0 1.0 88 Q96GD4,Q9NV56,P09874,Q7Z4V5,P35637,Q9UBU8,P24941,P46100 8 +Mammary gland epithelial cell proliferation 0.3745917700849083 0.1940676279336006 0.8461229288779755 1.0 1.0 5 Q15648,Q99623,Q92766,P28482 4 +Sphingomyelin catabolic process 0.5549755301794312 0.1940161895732543 0.8461632053194983 1.0 1.0 2 Q05655 1 +Regulation of alpha beta t cell activation 0.3213419111775984 0.1918287564431082 0.8478763448755411 1.0 1.0 11 P00813 1 +Nucleoside triphosphate metabolic process 0.2977360010177221 0.191698874982895 0.847978087278336 1.0 1.0 44 P00846,P06576,P00813,P09874,Q9H773,P55263 6 +Fc receptor signaling pathway 0.3596047976733294 0.1907579249355343 0.8487152543181868 1.0 1.0 6 Q16512,P07948,P19174 3 +5s class rrna transcription by rna polymerase iii 0.4177864054002074 0.1907407748538638 0.848728691409961 1.0 1.0 4 Q9Y5Q8,Q9Y5Q9 2 +Trna transcription 0.4177864054002074 0.1907407748538638 0.848728691409961 1.0 1.0 4 Q9Y5Q8,Q9Y5Q9 2 +Skin development 0.2986890543523848 0.1905185696348877 0.8489027932079531 1.0 1.0 37 O75844,Q15392,Q9Y3B8 3 +Extrinsic apoptotic signaling pathway via death domain receptors 0.2965360591580078 0.1897935982206093 0.8494708725999616 1.0 1.0 15 P49841 1 +Regulation of mitotic recombination 0.4170979348523368 0.1893213462949662 0.8498409659253889 1.0 1.0 4 P49959 1 +Negative regulation of myeloid cell differentiation 0.3121618793341437 0.187257835932396 0.8514584802173768 1.0 1.0 12 P07948,Q96T37 2 +Positive regulation of chromosome organization 0.2915258580538133 0.1839951448275762 0.854017263766021 1.0 1.0 50 P24941,P46100 2 +Sensory organ development 0.2874408427124504 0.1827594140070977 0.8549867951098788 1.0 1.0 53 P42892,P39210,P54802,O94788 4 +Positive regulation of vesicle fusion 0.5484502446981914 0.1824476588128049 0.8552314270666519 1.0 1.0 2 P07355 1 +Prolactin secretion 0.5484502446981911 0.1824476588128049 0.8552314270666519 1.0 1.0 2 Q7Z7E8 1 +Sister chromatid cohesion 0.2883532121132459 0.1805499577375437 0.8567208381365674 1.0 1.0 26 P23246,P49959,Q8WVM7,P53350,Q29RF7,P46100 6 +Negative regulation of protein kinase activity by regulation of protein phosphorylation 0.3686224393051019 0.1802871371641121 0.8569271532728207 1.0 1.0 5 P49593,P55265 2 +Suppression of viral release by host 0.4123618729735835 0.1797294741976421 0.8573649531554148 1.0 1.0 4 P19474,Q12899 2 +Regulation of dna repair 0.2894758705702384 0.1781876829171687 0.8585755825372665 1.0 1.0 51 Q9NV56,P09874,Q7Z4V5,Q9NYB0,P35637,Q9UBU8,Q9NPF5,Q9NY27 8 +Positive regulation of heart growth 0.5363526076385646 0.1777548448196478 0.8589155111060649 1.0 1.0 3 P06493 1 +Mitotic spindle assembly 0.2932153741652883 0.1776463813021898 0.8590006968218564 1.0 1.0 31 Q96GD4,O00139,P12270,Q9H0H5,Q8WVM7,Q9HD42,P53350,Q9ULW0 8 +Wound healing 0.2760850999420392 0.1774842836587093 0.8591280090824902 1.0 1.0 59 P42785,P08133,Q9UNN8,Q8WTV0,Q16625 5 +Neuron projection organization 0.2848338377046305 0.1773510112476966 0.8592326846122031 1.0 1.0 24 Q8N5V2,Q96HC4,P49841,Q9UQB8 4 +Reactive nitrogen species metabolic process 0.2935956746038333 0.1765986194318952 0.8598236785748021 1.0 1.0 18 Q92945,O43169,Q5VT66,P30536 4 +Nuclear envelope organization 0.2920232956162105 0.1760753679590015 0.8602347321029613 1.0 1.0 30 P17252,Q86XL3,P53350,O75844,P50402 5 +Cellular lipid metabolic process 0.3754938013637234 0.1751506881693557 0.8609612304074787 1.0 1.0 191 Q9NX62,P07099,O94788,O00459,Q15067,P37268,Q8NBX0,P23786,P33121,Q8N8N7,Q14914,Q8N4Q0,Q8WTV0,O15254,P42126,Q9NPH0,Q8NHP8,Q06136,Q8NCC3,Q8IVS2,O95864,P14174,O75844,Q9H7Z7,Q96G23,Q9BY49,P27544,P28288,P34913,P35610,Q9HB40,Q96N66,Q10713,Q9BWD1,Q15126 35 +Epithelial cell differentiation 0.2958695337593758 0.1740787958244837 0.8618035372415811 1.0 1.0 101 P20073,Q9Y3B8,P08670,P21796,O14773,P49840,P49841,P31942,Q8NEY8,P09525,P09960,P06493,P46100,P80723 14 +Regulation of peptidyl serine phosphorylation 0.292285615731651 0.1734340681573381 0.862310248325969 1.0 1.0 19 P35080,P14174 2 +Membrane invagination 0.2984110892110979 0.168832130932176 0.8659286842694316 1.0 1.0 13 Q96GD4,Q14185,P60953 3 +Trna catabolic process 0.3288758861795278 0.1687807060498871 0.8659691349306664 1.0 1.0 9 Q13868,Q08J23,Q15024 3 +Regulation of chromosome separation 0.2904426590138358 0.167956189845544 0.8666177448245982 1.0 1.0 30 P12270,Q96GD4,P53350,P49454 4 +Second messenger mediated signaling 0.2841804296214882 0.1669120399227391 0.8674392595596987 1.0 1.0 25 O75844,P49841 2 +Negative regulation of transcription by competitive promoter binding 0.5380097879282084 0.1650327688403486 0.8689181898716667 1.0 1.0 2 P35232 1 +Regulation of microtubule depolymerization 0.3052786100097562 0.1648183933917206 0.8690869262039309 1.0 1.0 12 Q8WWK9,Q9ULW0,P25054 3 +Regulation of histone h2b ubiquitination 0.5274855325379455 0.1634803427584759 0.8701402491428016 1.0 1.0 3 Q5VTR2 1 +Nucleosome organization 0.2799189131513106 0.1632759721365972 0.8703011514758556 1.0 1.0 56 P10412,Q01105,P84243,P07305,P25440,P16403,O14497,Q9NPF5,P46100,Q969G3 10 +Regulation of mitotic cell cycle spindle assembly checkpoint 0.35978662761251 0.1609045363645023 0.8721685893612845 1.0 1.0 5 P12270,P14635 2 +Selective autophagy 0.2849468864201444 0.1573342309967763 0.8749814437651489 1.0 1.0 27 P21796,Q96HY6,P27544 3 +N terminal protein amino acid modification 0.328547517696477 0.155102319017841 0.8767406539996061 1.0 1.0 8 Q9BV86,P53582,Q5VZE5 3 +Cellular component maintenance 0.328538738149712 0.1550786311763907 0.8767593282206154 1.0 1.0 8 Q14203,Q14247,Q15334,Q07157,Q96AC1,P56545,Q13614 7 +Pseudouridine synthesis 0.3325567683846738 0.1542119501194619 0.87744262006986 1.0 1.0 7 Q96PZ0,Q6P087 2 +Prostate gland development 0.3559764859568907 0.1529252744004431 0.8784572042470995 1.0 1.0 5 P04083,P35222,Q9NZJ7,P07602 4 +Tail anchored membrane protein insertion into er membrane 0.3162094824615781 0.1524998070863263 0.8787927425805007 1.0 1.0 10 Q7L5D6,Q9NPA0 2 +Regulation of arp2 3 complex mediated actin nucleation 0.3440052270499863 0.1524575248482179 0.8788260890155137 1.0 1.0 6 P53365,P60983,Q9Y2A7,Q9BR76,P53367 5 +Regulation of lipid metabolic process 0.2872846726553166 0.149335280651454 0.8812890774546835 1.0 1.0 49 O75844,Q8WTV0,P30536,Q96G23 4 +Regulation of establishment of protein localization 0.3211886638889147 0.148365590270916 0.8820542544765559 1.0 1.0 130 Q9Y282,O00459,P49840,Q14978,P06493,P50402,P55786,P49841,Q32P28,Q16850,Q9GZY8,P49755,Q9Y3B8,P12270,Q9NPF5,P53985,Q8N183,P17252,Q9UII2 19 +Regulation of translational fidelity 0.2834969872453971 0.1478337841751324 0.882473946354644 1.0 1.0 14 Q9NSE4,Q5ST30,Q99543 3 +Positive regulation of nervous system process 0.3533638145003283 0.1475868209251294 0.8826688565699641 1.0 1.0 5 P04062,Q9UPY3,Q14118,Q8TEW0 4 +Sensory system development 0.289235802516759 0.1456955317324111 0.8841617488908533 1.0 1.0 34 P54802,O94788 2 +Spliceosomal tri snrnp complex assembly 0.3057096877830117 0.1435370429534997 0.8858660580773909 1.0 1.0 11 O75494 1 +Positive regulation of deoxyribonuclease activity 0.5130548302872 0.1420410935541933 0.8870475467756271 1.0 1.0 3 Q05655,P23396 2 +Positive regulation of telomere maintenance 0.2828184342974762 0.1410457738935225 0.8878337814278972 1.0 1.0 28 P46100 1 +Regulation of wnt signaling pathway 0.2888638970268816 0.1408803172980246 0.8879644915749323 1.0 1.0 45 Q96C57,Q9H2V7,P49840,P49841,P50402 5 +Neuron projection guidance 0.2830905057423203 0.1395368218947951 0.889025960874195 1.0 1.0 20 P42892 1 +Axis specification 0.3267973856209174 0.1394995085223634 0.8890554442850338 1.0 1.0 7 Q9Y2W6,P35222,Q9HCM4,Q99496,Q9BQA1,P80723 6 +Dna replication 0.2998716701944254 0.1393312640980496 0.8891883856478482 1.0 1.0 109 Q15004,Q9Y619,Q6IQ49,P41440,P06493,P24941,P46100,O75844 8 +Apoptotic chromosome condensation 0.5207177814029206 0.1391325386477133 0.8893454161566654 1.0 1.0 2 P11388 1 +Cell cycle phase transition 0.3228447314272163 0.138771713943444 0.8896305466799856 1.0 1.0 133 Q96GD4,Q9Y619,Q96RU2,P49454,Q96DY7,P08183,Q6IQ49,Q96K76,Q8N6R0,Q96HY6,O43823,P53350,P06493,P24941,Q68E01 15 +Maintenance of protein location 0.2810117877442898 0.1385152845350914 0.8898331907418775 1.0 1.0 27 Q12792,P30536 2 +Regulation of dna metabolic process 0.329022809457226 0.1369153249478797 0.8910977253567023 1.0 1.0 140 P10412,Q6NSI4,Q9NV56,O95831,P20585,P35637,P24941,O75844,P46100,Q96GD4,Q03164,P07305,Q7Z4V5,Q9NYB0,P27544,Q9UBU8,Q9NPF5,P22626,P39210,Q99543,P09874,Q86W56,P49959,P09651,P16403,Q8NB78,Q9NY27 27 +Positive regulation of translation 0.2686059396509395 0.1363368395693681 0.8915550020035898 1.0 1.0 60 Q13217,Q6P087,P08670,Q567V2,P67809,Q14011 6 +Regulation of wound healing spreading of epidermal cells 0.3875285667646169 0.1344286349979268 0.8930636396771485 1.0 1.0 4 Q96AC1,Q92766,Q7Z460 3 +Wound healing spreading of epidermal cells 0.3875285667646169 0.1344286349979268 0.8930636396771485 1.0 1.0 4 Q96AC1,Q92766,Q7Z460 3 +Positive regulation of epithelial to mesenchymal transition 0.3875285667646106 0.1344286349979164 0.8930636396771567 1.0 1.0 4 Q92769,Q96AC1,P35222 3 +Rrna transcription 0.2791416199994189 0.1328792153415148 0.8942889048753062 1.0 1.0 22 Q13428,P19338,Q9H2V7,Q9Y5Q8,O15446 5 +Striated muscle adaptation 0.3856076312965039 0.1312764359343177 0.895556631855912 1.0 1.0 4 Q08209,P16615 2 +Peptidyl lysine trimethylation 0.2808572742630279 0.1308199696142086 0.8959177252888681 1.0 1.0 20 P46100 1 +Positive regulation of neurotransmitter uptake 0.5141924959216795 0.1302988466970803 0.8963299924943084 1.0 1.0 2 P20337 1 +Cellular defense response 0.5141924959216795 0.1302988466970803 0.8963299924943084 1.0 1.0 2 Q08380 1 +Positive regulation of chromatin binding 0.5125611745513694 0.1281696189053362 0.8980147423396527 1.0 1.0 2 O60341 1 +Response to vitamin d 0.3325548538797915 0.1269968541352407 0.8989428884263442 1.0 1.0 6 Q8TB36,Q15648,O15164 3 +Endoplasmic reticulum unfolded protein response 0.2803156940070953 0.1265299689472308 0.899312427888884 1.0 1.0 18 Q96HY6 1 +Regulation of small gtpase mediated signal transduction 0.2853448853739513 0.1259139597245868 0.8998000323637534 1.0 1.0 34 Q9H0H5,P41440 2 +Positive regulation of peptidase activity 0.287194434871145 0.1251735200628191 0.9003861802696382 1.0 1.0 39 P61604,Q9NR28,O95831,Q96HY6,Q96A26,Q96F07 6 +Regulation of receptor catabolic process 0.3806725432582425 0.12340980691601 0.9017825916417764 1.0 1.0 4 Q96J02,Q13614,P07355 3 +Establishment of epithelial cell apical basal polarity 0.3806205574274302 0.1233287133718841 0.9018468044062168 1.0 1.0 4 P60953 1 +Regulation of telomere maintenance 0.2868648636797603 0.1229027113377989 0.9021841385695668 1.0 1.0 40 Q96GD4,P09874,Q9NYB0,P49959,P09651,P22626,P46100 7 +Regulation of lamellipodium assembly 0.2761989227786964 0.1200427037498366 0.9044493198249586 1.0 1.0 15 Q12792 1 +Negative chemotaxis 0.5060358890701306 0.1199657149098148 0.9045103073062604 1.0 1.0 2 O94813 1 +Negative regulation of synapse organization 0.5060358890701306 0.1199657149098148 0.9045103073062604 1.0 1.0 2 O00264 1 +Neurotransmitter receptor localization to postsynaptic specialization membrane 0.5057096247960712 0.1195685653547868 0.9048249222466518 1.0 1.0 2 Q14118 1 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.3143441897908705 0.1187541692552868 0.9054701192880952 1.0 1.0 8 Q7L5D6 1 +Mirna metabolic process 0.318080536925589 0.1184292460877621 0.9057275538072492 1.0 1.0 7 Q92945 1 +Regulation of mrna metabolic process 0.328554146390527 0.117879338882656 0.9061632642769823 1.0 1.0 142 Q92615,P08670,P07910,Q13868,Q13464,P18615,Q99729,P98179,P35637,P21127,P98175,Q5VTR2,P51116,Q13595,Q16630,Q92945,Q6L8Q7,Q9P2K5,Q96T37,Q9NQT4,Q16629,P19338,Q969T7,Q92804,Q8IY67,Q15024,P22626,Q14011,Q13242,P61978,Q9BWF3,O75525,Q8N684,O75494,P38159,Q5PRF9,P09651,P17252,P62995,Q13151,P67809 41 +Aminoacyl trna metabolism involved in translational fidelity 0.3016303439779977 0.1129949607200435 0.9100345503904744 1.0 1.0 10 Q9NSE4,Q5ST30 2 +Platelet derived growth factor receptor beta signaling pathway 0.490209745899364 0.1125889291276652 0.9103564625138312 1.0 1.0 3 O00291 1 +Embryonic body morphogenesis 0.4898825065274094 0.1122063089412063 0.9106598269510376 1.0 1.0 3 Q9Y2X9,Q14118 2 +Negative regulation of cellular response to growth factor stimulus 0.3073558003174041 0.1114581149243906 0.911253078038053 1.0 1.0 9 O14936,Q05D32 2 +Negative regulation of proteasomal protein catabolic process 0.2744434197338876 0.1093121971730644 0.9129548726246705 1.0 1.0 21 O94966,Q96HY6,Q92530,Q9UL15,P46379 5 +Trophoblast cell migration 0.4959216965742063 0.108222132850165 0.913819488588292 1.0 1.0 2 Q07021 1 +Regulation of dendritic cell chemotaxis 0.4959216965742063 0.108222132850165 0.913819488588292 1.0 1.0 2 Q07021 1 +Negative regulation of immune effector process 0.2996789969121014 0.1080650460844933 0.9139440949209114 1.0 1.0 10 P04439 1 +Hydrogen sulfide biosynthetic process 0.4949429037520265 0.1071472100938273 0.9146721944746684 1.0 1.0 2 P25325 1 +Hydrogen sulfide metabolic process 0.4949429037520265 0.1071472100938273 0.9146721944746684 1.0 1.0 2 P25325 1 +Regulation of cell matrix adhesion 0.2709503538866911 0.1055774916449986 0.915917583987042 1.0 1.0 23 O14936,P49593,Q13464,P49841,Q9H2G2,P46939 6 +Sno s rna metabolic process 0.2918737069730951 0.1055237030996217 0.9159602626336718 1.0 1.0 11 Q14978,Q9NQT4 2 +R loop disassembly 0.4840078328981684 0.1055222794304387 0.9159613922505928 1.0 1.0 3 Q9NY93,Q9BUQ8 2 +Rhythmic process 0.2745870347940152 0.1052465780029258 0.9161801520236575 1.0 1.0 54 Q8WXF1,Q9BQG2,Q9BWF3,Q03164,P23246,Q13185,P49841,Q15233,P54802,P06493,Q9Y2W1 11 +Regulation of reactive oxygen species metabolic process 0.2784515988847629 0.1047706161349963 0.9165578266231303 1.0 1.0 31 P42785,P30536 2 +Cerebral cortex development 0.2719897219952344 0.1041346326329767 0.9170625073867316 1.0 1.0 26 P49841,Q96N66 2 +Negative regulation of cellular respiration 0.4822810875480274 0.1036237815892688 0.9174679142809667 1.0 1.0 3 Q6L8Q7 1 +Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.4913539967373452 0.1032971137290924 0.9177271662772832 1.0 1.0 2 P23396 1 +Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest 0.4913539967373437 0.103297113729091 0.9177271662772843 1.0 1.0 2 P04637 1 +Protein acylation 0.2742732236096677 0.1032079767131025 0.9177979092208794 1.0 1.0 54 Q9NV56,P49841,Q9UBU8,Q9NPF5,O75844 5 +Postsynapse to nucleus signaling pathway 0.4910277324632769 0.1029541727925349 0.917999342416965 1.0 1.0 2 P52292 1 +Regulation of spontaneous synaptic transmission 0.4900489396410923 0.101932371322516 0.9188103551771368 1.0 1.0 2 P05556 1 +Spontaneous synaptic transmission 0.4900489396410923 0.101932371322516 0.9188103551771368 1.0 1.0 2 P05556 1 +Gamma aminobutyric acid signaling pathway 0.4900489396410902 0.1019323713225138 0.9188103551771384 1.0 1.0 2 P04899 1 +Ammonium transmembrane transport 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 1.0 2 Q9Y666 1 +Regulation of extracellular matrix assembly 0.4897226753670396 0.101594106013688 0.919078857962908 1.0 1.0 2 Q14118 1 +Positive regulation of basement membrane assembly involved in embryonic body morphogenesis 0.4897226753670396 0.101594106013688 0.919078857962908 1.0 1.0 2 Q14118 1 +Positive regulation of extracellular matrix assembly 0.4897226753670396 0.101594106013688 0.919078857962908 1.0 1.0 2 Q14118 1 +Positive regulation of keratinocyte differentiation 0.3272370999346806 0.1002058824301409 0.9201808760194204 1.0 1.0 5 P22392,Q15648,Q14980,O75367 4 +Secretory granule localization 0.4787859007832907 0.0998719763775389 0.9204459647024206 1.0 1.0 3 Q12756,P33176 2 +Response to arsenic containing substance 0.2674192145742699 0.0990464128484261 0.9211014191264876 1.0 1.0 14 P09601,P36551,Q9BWF3 3 +Histone deacetylation 0.26887250565629 0.0975252963173934 0.9223092464224384 1.0 1.0 25 Q8WXI9,Q96PK6,O43823,Q9UBU8,Q12873 5 +Regulation of viral transcription 0.362063336598114 0.0967217551319014 0.9229473627335574 1.0 1.0 4 P19474,Q08211,Q96T23 3 +Serine family amino acid metabolic process 0.2742209208765483 0.0963180060278269 0.9232680108311088 1.0 1.0 13 O75600 1 +Inner cell mass cell differentiation 0.483197389885797 0.0950712629176594 0.9242582235323856 1.0 1.0 2 Q6PD62 1 +Muscle structure development 0.276043931127751 0.0944075610335113 0.9247854097973648 1.0 1.0 91 Q9Y4W6,P85037,P49454,P49840,Q7Z4V5,O75446,P41440,P06493,P67809,Q8NEZ5,P50402,O75844 12 +Positive regulation of mitochondrial membrane potential 0.4728750901508733 0.0938013732810513 0.9252669407762404 1.0 1.0 3 Q8IWA4 1 +Endoderm development 0.2937117010344219 0.09352190721159 0.925488946525844 1.0 1.0 10 Q92541,Q8N7H5,P35222,P07942 4 +Fc gamma receptor signaling pathway 0.3225822096089048 0.0929091401879298 0.9259757443392488 1.0 1.0 5 Q16512,P07948 2 +Regulation of protein stability 0.2901121195524532 0.0919388691181797 0.9267466091349688 1.0 1.0 105 Q96AB3,P35080,Q7L5D6,O75718,Q86Y82,Q32P28,Q96HY6,P41440,P53350 9 +Negative regulation of cellular catabolic process 0.2745103168306008 0.0905077777290993 0.9278837135879034 1.0 1.0 90 Q92615,P85037,P07910,Q9H7Z3,P49840,Q13464,Q99729,P35637,Q92530,Q9UL15,P98175,O15118,Q96HY6,Q92804,Q9P275,P30536,P09601,Q14011,P46379,Q13151,Q13614,P67809,Q9Y2W1 23 +Rna destabilization 0.2803940943758786 0.0900012259390912 0.9282862406253642 1.0 1.0 39 Q13868,Q969T7,Q13464,Q5PRF9,Q6L8Q7,Q15024,Q86VM9,P67809,Q9NQT4 9 +Amine metabolic process 0.2658706290341913 0.0893953038949523 0.9287677554795496 1.0 1.0 15 O14874 1 +Positive regulation of myelination 0.3532484492327807 0.0856919180134852 0.9317113269873818 1.0 1.0 4 Q9UPY3,Q14118,Q8TEW0 3 +Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii 0.4727569331158056 0.0855699874643262 0.9318082574586228 1.0 1.0 2 Q9NVJ2 1 +Negative regulation of endothelial cell proliferation 0.3110234304501498 0.0853641489246637 0.93197189410667 1.0 1.0 6 Q9UII2 1 +Negative regulation of b cell activation 0.3171129980404942 0.0847732133881416 0.9324416894822762 1.0 1.0 5 Q16512,Q96FV9,P07948,O15347 4 +Snrna transport 0.351687994777585 0.0838448050259724 0.9331798241530048 1.0 1.0 4 Q09161,Q9H814 2 +Regulation of ligase activity 0.462140992167098 0.0836382413417358 0.9333440612483844 1.0 1.0 3 P48507,Q9UBB9 2 +Heart formation 0.4701468189233196 0.0833686864844364 0.9335583863764024 1.0 1.0 2 P35222 1 +Regulation of bicellular tight junction assembly 0.3019481760380418 0.0833174151223473 0.9335991531740764 1.0 1.0 7 P17252 1 +Lamellipodium assembly 0.2674530224528395 0.0822413620617103 0.9344547826594244 1.0 1.0 19 Q12792,Q16625,P60953 3 +Microtubule depolymerization 0.2670012171007098 0.082144061858837 0.9345321551965576 1.0 1.0 18 Q8WWK9,O00139,Q9ULW0,P25054 4 +Labyrinthine layer blood vessel development 0.4678629690048879 0.0814980600785336 0.9350458675816378 1.0 1.0 2 P28482 1 +Negative regulation of histone h3 k4 methylation 0.4585509138381149 0.0804806583622484 0.935854978720482 1.0 1.0 3 P61964,O60341 2 +Regulation of microtubule based movement 0.3139377667229586 0.0802647039814622 0.9360267297536812 1.0 1.0 5 P78318 1 +Negative regulation of response to dna damage stimulus 0.2646679532983532 0.0801557558293553 0.9361133786177528 1.0 1.0 25 P14174 1 +Regulation of dna binding transcription factor activity 0.2567429103870483 0.0799604184380938 0.9362687366396668 1.0 1.0 62 O75381,Q00577,P09525,Q96HY6,P41440 5 +Regulation of synapse assembly 0.300000000000002 0.0794221288982649 0.936696867920439 1.0 1.0 7 Q13641,Q15375,Q96QK1,Q96HC4,Q04637,Q9H2P0 6 +Dna methylation dependent heterochromatin assembly 0.2872644903894598 0.0787175233389668 0.9372573071215188 1.0 1.0 10 Q9Y6X9,O95983,Q8NEY8 3 +Negative regulation of blood circulation 0.4562663185378532 0.0785328616577129 0.9374041911107632 1.0 1.0 3 P30626,P16615 2 +Fear response 0.455939947780669 0.0782584779653265 0.9376224459064236 1.0 1.0 3 Q04637,P51608 2 +Regulation of atp dependent activity 0.2687823585792735 0.0780781750928165 0.9377658679395364 1.0 1.0 28 P35080,Q8IXB1,P20585 3 +Mitochondrial protein catabolic process 0.4629690048939561 0.0776607103786637 0.9380979482500502 1.0 1.0 2 Q96TA2 1 +Positive regulation of ligase activity 0.4619902120717627 0.076920780512287 0.9386865660647428 1.0 1.0 2 P48507 1 +Organic hydroxy compound biosynthetic process 0.2744385842332452 0.0766425596630236 0.938907900790494 1.0 1.0 50 P37268,Q15392,Q16850,P28288,Q14739,Q9UBM7,Q9H4L5,Q15126 8 +Postsynaptic modulation of chemical synaptic transmission 0.3437806072478025 0.0749628189817755 0.9402442947769928 1.0 1.0 4 Q08209,P38919,P06730 3 +Regulation of translation at synapse modulating synaptic transmission 0.3437806072477955 0.0749628189817677 0.9402442947769992 1.0 1.0 4 P35268,P38919,P06730 3 +Stress granule assembly 0.2657032045571016 0.0746407390675137 0.940500559423437 1.0 1.0 13 Q14011 1 +Entrainment of circadian clock 0.3097318837831959 0.0745333797745896 0.9405859818027522 1.0 1.0 5 P04637,Q13330,Q9BWF3 3 +Negative regulation of autophagosome assembly 0.4580750407830262 0.0740509647768083 0.9409698325158944 1.0 1.0 2 Q8WVM8 1 +Folic acid containing compound catabolic process 0.4507180156657863 0.0739984024893572 0.9410116564061856 1.0 1.0 3 P49914,Q9NRN7 2 +Rrna catabolic process 0.2653048698884688 0.0736769805802177 0.9412674158319498 1.0 1.0 13 Q9NQT4,Q9BQ61,Q15024 3 +Regulation of hormone biosynthetic process 0.456117455138652 0.0726691870063442 0.942069368906006 1.0 1.0 2 P16435 1 +Regulation of steroid hormone biosynthetic process 0.456117455138652 0.0726691870063442 0.942069368906006 1.0 1.0 2 P16435 1 +Negative regulation of immune system process 0.2772239160347783 0.0725532129088814 0.9421616592316776 1.0 1.0 41 P07948,P04439,P28070,P00813,P14174 5 +Dna conformation change 0.3127700281781673 0.0715575170751119 0.9429540498233996 1.0 1.0 131 O75151,P10412,Q9H7Z3,O95831,Q00577,O43823,P06493,P24941,P84243,Q12873,P46100,P12270,P07305,Q8NEY8,P53350,P22626,P49959,P25440,Q01105 19 +Changes to dna methylation involved in embryo development 0.4518760195758461 0.0697940581334443 0.9443575765691103 1.0 1.0 2 Q13263 1 +Negative regulation of smooth muscle cell apoptotic process 0.4518760195758425 0.0697940581334421 0.944357576569112 1.0 1.0 2 Q8NDZ4 1 +Positive regulation of protein polymerization 0.2632061597376999 0.0676773754737808 0.946042459766135 1.0 1.0 26 P35080,Q16625 2 +Integrin activation 0.4422323759791191 0.0675858220463743 0.9461153419587948 1.0 1.0 3 Q96AC1,Q9BX67 2 +Negative regulation of double strand break repair via homologous recombination 0.3037230568256042 0.0668148282879513 0.9467291185223708 1.0 1.0 5 Q9NRR5,A6NHR9,Q12888,Q6NSI4 4 +Gastrulation with mouth forming second 0.3352921971923038 0.0662964472767144 0.947141811666572 1.0 1.0 4 Q4VCS5,P35222,Q99496 3 +Cellular response to peptide 0.2509596266541885 0.0658485072890721 0.94749843677736 1.0 1.0 71 P07948,P08670,O00459,P49840,Q13464,Q9Y4I1,P49841,P09874,Q9UQB8 9 +Embryonic cranial skeleton morphogenesis 0.43635770234987 0.0635034296234876 0.9493656283136912 1.0 1.0 3 P38919,Q6UB35 2 +Regulation of receptor localization to synapse 0.4359779607802956 0.063249311878155 0.949567978154862 1.0 1.0 3 O15400 1 +Cellular response to radiation 0.2752971204686535 0.0629538848943924 0.9498032259604264 1.0 1.0 43 Q96GD4,Q96RU2,P09874,Q6IQ49,P27544,O75844 6 +Coronary vasculature development 0.4354041143762724 0.0628675218186885 0.9498719974998836 1.0 1.0 3 Q15750 1 +Positive regulation of substrate adhesion dependent cell spreading 0.2604408754046975 0.0622691113464817 0.9503485263 1.0 1.0 13 P60953,Q14185,P07237 3 +Cell cell signaling by wnt 0.2582196364777796 0.0617409424732478 0.9507691347663708 1.0 1.0 60 Q14696,Q96C57,Q9H2V7,P49840,P49841,P20339,P25054,Q96K76,P50402 9 +Response to l phenylalanine derivative 0.437846655791179 0.0613854367624798 0.951052250266518 1.0 1.0 2 P48507 1 +Response to thyroxine 0.437846655791179 0.0613854367624798 0.951052250266518 1.0 1.0 2 P48507 1 +Negative regulation of microtubule polymerization or depolymerization 0.252599870525344 0.0609776993046856 0.9513769693758998 1.0 1.0 14 Q8WWK9,Q9ULW0,P25054 3 +Pathway restricted smad protein phosphorylation 0.3289817823352542 0.0604169654638358 0.9518235468534344 1.0 1.0 4 Q93062,Q07954 2 +Cellular glucose homeostasis 0.2681117471970466 0.0593284353902541 0.9526905128330292 1.0 1.0 31 Q8N5M9,P85037,O00459,Q8N183,Q99808,P17252,Q8IWT6 7 +Negative regulation of metallopeptidase activity 0.4339314845024385 0.0593234904264773 0.9526944514061366 1.0 1.0 2 Q07954 1 +Mitochondrial membrane organization 0.2726962998303067 0.058531095100953 0.9533255946350944 1.0 1.0 48 Q9Y4W6,Q9NS69,Q9Y584,P49840,Q8IWA4,P49841,Q8WWC4,Q9UII2 8 +Negative regulation of single stranded viral rna replication via double stranded dna intermediate 0.3264773098269715 0.0582128071951664 0.9535791193563704 1.0 1.0 4 Q15047,Q9Y6X9,Q13263 3 +Positive regulation of rho protein signal transduction 0.4313213703099428 0.058013921545688 0.9537375394140264 1.0 1.0 2 Q9Y624 1 +Regulation of hippo signaling 0.4293637846655704 0.0570650383622759 0.9544933863656312 1.0 1.0 2 Q01085 1 +Complement activation 0.4255874673629324 0.0567407501242449 0.954751712382159 1.0 1.0 3 Q07021,P35232 2 +Regulation of complement activation 0.4255874673629324 0.0567407501242449 0.954751712382159 1.0 1.0 3 Q07021,P35232 2 +Regulation of humoral immune response 0.4255874673629324 0.0567407501242449 0.954751712382159 1.0 1.0 3 Q07021,P35232 2 +Mammary gland duct morphogenesis 0.4255874673629261 0.0567407501242413 0.9547517123821618 1.0 1.0 3 Q15648,Q14160 2 +Regulation of morphogenesis of an epithelium 0.4254486133768318 0.0552506539949276 0.9559387744809448 1.0 1.0 2 P35222 1 +Branching involved in mammary gland duct morphogenesis 0.4254486133768311 0.0552506539949274 0.9559387744809452 1.0 1.0 2 Q15648 1 +Positive regulation of microtubule nucleation 0.2935989549314143 0.055030312515968 0.9561143144795032 1.0 1.0 5 Q16512,Q14203,P51608,Q14008 4 +Pyrimidine nucleoside metabolic process 0.4216710182767556 0.0545029618297147 0.9565344489002944 1.0 1.0 3 P84090,P04183 2 +Regulation of cytoplasmic mrna processing body assembly 0.4213446475195815 0.0543216245363819 0.9566789210991162 1.0 1.0 3 Q9HBH5,Q9NZN8 2 +Adherens junction maintenance 0.4218597063621443 0.0536822147411934 0.9571883529478072 1.0 1.0 2 Q96AC1 1 +Cell cell junction maintenance 0.4218597063621443 0.0536822147411934 0.9571883529478072 1.0 1.0 2 Q96AC1 1 +Negative regulation of catabolic process 0.2780576494173125 0.0532763277832592 0.9575117411016364 1.0 1.0 98 Q92615,P85037,P07910,Q9H7Z3,P49840,Q13464,Q99729,P35637,Q92530,Q9UL15,P98175,O15118,Q16850,Q96HY6,Q92804,Q9P275,P30536,P09601,Q14011,P46379,Q13151,Q13614,P67809,Q9Y2W1 24 +Photoperiodism 0.3205026336786004 0.0532430351048908 0.9575382671671662 1.0 1.0 4 Q13330,Q9BWF3 2 +Cellular response to heat 0.2624179586727304 0.0523411773164912 0.9582568435117798 1.0 1.0 28 P07948,P12270,P49841,P17252,Q99543 5 +Amyloid beta clearance by cellular catabolic process 0.4182707993474662 0.0522011281052845 0.9583684340629356 1.0 1.0 2 Q07954 1 +Bone resorption 0.2824547968823154 0.0519757742413972 0.958547996670724 1.0 1.0 8 O14773 1 +Rna capping 0.3183153770812966 0.0515231243171285 0.9589086757798722 1.0 1.0 4 Q09161,O43148,Q53F19 3 +Ribonucleoprotein complex disassembly 0.2900065316786382 0.0512068187051467 0.9591607184340488 1.0 1.0 5 Q14562,Q07866,Q9UBB9,P33176 4 +Isotype switching to iga isotypes 0.4148172323759848 0.0508567362593678 0.9594396803323364 1.0 1.0 3 O96028,Q96FV9 2 +Positive regulation of isotype switching to iga isotypes 0.4146818923327843 0.0508042206256169 0.959481527649525 1.0 1.0 2 O96028 1 +Fungiform papilla morphogenesis 0.4127243066884141 0.050076619939316 0.9600613309432326 1.0 1.0 2 P35222 1 +Tongue development 0.4127243066884141 0.050076619939316 0.9600613309432326 1.0 1.0 2 P35222 1 +Hair follicle placode formation 0.4127243066884141 0.050076619939316 0.9600613309432326 1.0 1.0 2 P35222 1 +Ectodermal placode development 0.4127243066884141 0.050076619939316 0.9600613309432326 1.0 1.0 2 P35222 1 +Tongue morphogenesis 0.4127243066884141 0.050076619939316 0.9600613309432326 1.0 1.0 2 P35222 1 +Fungiform papilla development 0.4127243066884141 0.050076619939316 0.9600613309432326 1.0 1.0 2 P35222 1 +Regulation of excretion 0.4091353996737334 0.0488035928901814 0.96107581887617 1.0 1.0 2 P04899 1 +Renal sodium excretion 0.4091353996737334 0.0488035928901814 0.96107581887617 1.0 1.0 2 P04899 1 +Regulation of renal system process 0.4091353996737334 0.0488035928901814 0.96107581887617 1.0 1.0 2 P04899 1 +Renal tubular secretion 0.4091353996737334 0.0488035928901814 0.96107581887617 1.0 1.0 2 P04899 1 +Positive regulation of renal sodium excretion 0.4091353996737334 0.0488035928901814 0.96107581887617 1.0 1.0 2 P04899 1 +Positive regulation of phagocytosis 0.2804838182412548 0.0485287967152444 0.9612948150121572 1.0 1.0 8 Q4KMQ2,Q12907,P27797,Q13636,P50570,Q08722,Q9NX58 7 +Positive regulation of mitochondrial calcium ion concentration 0.2870672762900038 0.0482143062766542 0.9615454486877985 1.0 1.0 5 Q96AQ8,P51572,Q9BPX6,Q8NE86 4 +Regulation of cell cycle checkpoint 0.2660340314136102 0.0469462665968298 0.9625560533098568 1.0 1.0 11 Q96QC0,P15927,Q13838,P12270,Q13257,Q9Y6G9,Q13769,P14635,Q8N163,Q96FV9 10 +Negative regulation of arp2 3 complex mediated actin nucleation 0.3947797716150028 0.0444422257540185 0.964551903597143 1.0 1.0 2 Q9BR76 1 +Negative regulation of actin nucleation 0.3947797716150028 0.0444422257540185 0.964551903597143 1.0 1.0 2 Q9BR76 1 +Epithelial cell proliferation involved in lung morphogenesis 0.3996264817111054 0.0439195279269668 0.9649685492843274 1.0 1.0 3 P60953 1 +Negative regulation of dna dependent dna replication 0.392495921696563 0.0438476953388593 0.9650258082369504 1.0 1.0 2 P49916 1 +Regulation of cytoplasmic translational initiation 0.3872756933115776 0.04258193631244 0.9660347951627388 1.0 1.0 2 P40429 1 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.2809427973763798 0.0423624559670555 0.9662097572642134 1.0 1.0 5 Q99729,P38919 2 +Negative regulation of cholesterol metabolic process 0.3836867862968968 0.0417832551510279 0.966671483808691 1.0 1.0 2 O75477 1 +Negative regulation of alcohol biosynthetic process 0.3836867862968968 0.0417832551510279 0.966671483808691 1.0 1.0 2 O75477 1 +Histone dephosphorylation 0.3939197746807639 0.0416898935776179 0.9667459107147588 1.0 1.0 3 Q9NY27 1 +Inflammasome complex assembly 0.381076672104398 0.0412371085362834 0.9671068704871444 1.0 1.0 2 O00571 1 +Postsynapse organization 0.2658806333809304 0.04118047927045 0.9671520157557076 1.0 1.0 33 Q96EY1,P49354,Q16352,Q14696,Q8N5V2,Q96HC4,Q9UQB8 7 +Mitochondrion endoplasmic reticulum membrane tethering 0.3909921671018341 0.0406201624161829 0.967598710137474 1.0 1.0 3 O43865,P16615 2 +Regulation of extrinsic apoptotic signaling pathway 0.2592086908403748 0.0400531084050763 0.9680507858488168 1.0 1.0 28 P49841 1 +Positive regulation of wound healing spreading of epidermal cells 0.3874020887728494 0.0393742479730167 0.9685920111239612 1.0 1.0 3 Q96AC1,Q92766 2 +Dendritic spine maintenance 0.3845940701163827 0.0384487424150271 0.9693298988622404 1.0 1.0 3 Q13614 1 +Negative regulation of steroid metabolic process 0.3838120104438687 0.03819844797563 0.9695294583304576 1.0 1.0 3 P05023,O75477 2 +Regulation of cardiac conduction 0.2762002733817939 0.0381773701513784 0.9695462637427305 1.0 1.0 5 P17252 1 +Negative regulation of viral transcription 0.3618270799347425 0.0380074597676594 0.9696817342927376 1.0 1.0 2 P19474 1 +Cellular response to acid chemical 0.2553739540295174 0.0379810800684733 0.9697027670608768 1.0 1.0 12 Q6IAA8,Q9UQB8 2 +Digestive tract morphogenesis 0.359216965742248 0.0376648221013873 0.9699549239797024 1.0 1.0 2 P35222 1 +Neural plate development 0.359216965742248 0.0376648221013873 0.9699549239797024 1.0 1.0 2 P35222 1 +Foregut morphogenesis 0.359216965742248 0.0376648221013873 0.9699549239797024 1.0 1.0 2 P35222 1 +Primary amino compound metabolic process 0.3582381729200628 0.0375414932730314 0.9700532566020664 1.0 1.0 2 P05091 1 +Negative regulation of erk1 and erk2 cascade 0.2418439293758121 0.0375153678361039 0.9700740870110705 1.0 1.0 14 Q96S59,Q99956 2 +Transmembrane transport 0.3783842502615986 0.0374614971312578 0.97011703942185 1.0 1.0 218 Q6NT16,Q99595,Q9H2V7,P49840,P08183,O43772,O95831,Q8IXU6,P23786,P33121,P41440,Q15629,Q8WTV0,O60830,Q9UHG3,P00846,Q8TDW0,O75381,O15439,P30825,O75844,Q16625,P49755,Q9NS69,Q14728,Q9Y619,Q9BQT8,Q8TAD4,Q99808,P28288,P53985,P39210,P03915,Q6P4Q7,Q70HW3 35 +Copper ion transport 0.3556280587275671 0.0372258952216754 0.970304891517166 1.0 1.0 2 P35670 1 +Positive regulation of jun kinase activity 0.380548302872062 0.0371881842824524 0.9703349596735054 1.0 1.0 3 Q16512,P23396 2 +Epithelium development 0.3316207600583735 0.0370583147974133 0.9704385091532606 1.0 1.0 157 P08670,O94788,P49840,P31942,P06493,O14773,P49841,O75844,P42892,Q96T37,P46100,P80723,Q9Y3B8,P21796,Q8NEY8,P09525,P20073,P35610,Q92796,P25440,P17252 21 +Positive regulation of phospholipase activity 0.2776870303822273 0.0368528988050721 0.970602295520706 1.0 1.0 6 Q99623,Q9Y263,P18085,Q14344,P35232 5 +Positive regulation of lipase activity 0.2776870303822273 0.0368528988050721 0.970602295520706 1.0 1.0 6 Q99623,Q9Y263,P18085,Q14344,P35232 5 +Response to ether 0.378916449086164 0.0367033627147626 0.9707215273927036 1.0 1.0 3 P11802,Q14103 2 +Regulation of mitochondrial fission 0.2707652060170038 0.036336128492422 0.9710143425795345 1.0 1.0 9 Q27J81,Q96QK1,Q9NQG6,Q8NE86,Q96HS1,Q9GZY8,O00429,P11233 8 +Nuclear body organization 0.377610966057442 0.0363250329436401 0.9710231897059638 1.0 1.0 3 Q15637,O75312 2 +Membrane protein intracellular domain proteolysis 0.3455138662316445 0.0361713372904083 0.9711457405564908 1.0 1.0 2 Q92542 1 +Regulation of mammary gland epithelial cell proliferation 0.3743472584856456 0.0354154035339929 0.9717485021730315 1.0 1.0 3 Q99623,Q92766 2 +Regulation of morphogenesis of a branching structure 0.3743472584856441 0.0354154035339926 0.971748502173032 1.0 1.0 3 Q99623,P35222 2 +Error free translesion synthesis 0.3353996737357247 0.0353495658883625 0.9718010001420684 1.0 1.0 2 Q9Y2S7 1 +Regulation of erad pathway 0.2714553879441865 0.0342823901326066 0.972651967253688 1.0 1.0 5 O94966,P51572,P46379 3 +Cell proliferation in forebrain 0.3635770234986988 0.032759286391209 0.9738665455260191 1.0 1.0 3 Q15154,Q9NZI8 2 +Vesicle tethering 0.2870322116895762 0.0322339532199788 0.9742854794859196 1.0 1.0 4 O95772 1 +Negative regulation of lipase activity 0.3606396866840755 0.0321208194921196 0.9743757004218788 1.0 1.0 3 P16435,P04083 2 +Epithelial cell differentiation involved in prostate gland development 0.3580287206266336 0.0315821239201715 0.9748052993237044 1.0 1.0 3 P35222,P07602 2 +Negative regulation of cellular component organization 0.3343073573414938 0.0315103988581351 0.9748624991745408 1.0 1.0 161 O75151,P08670,Q9NR77,Q13464,Q96PK6,Q9ULW0,Q12792,P49841,P46100,P35080,Q96GD4,Q96G23,P49454,P12270,Q96DY7,Q9NYB0,Q8N5V2,P30536,Q9NQX7,P53350,O95104,P09874,Q99536,O14976,Q9UHB6 25 +Glutamate biosynthetic process 0.3511749347258492 0.0302902460285861 0.975835575546592 1.0 1.0 3 O75746,P00367 2 +Cellular component disassembly 0.3349020668972083 0.0295937489425248 0.9763910507529568 1.0 1.0 162 Q969G3,Q12792,P49840,P49841,O95831,Q96HY6,P27544,P30536,P41440,P53350,P06493,P53990,Q9UHB6,O95104,O75844 15 +Regulation of endothelial cell differentiation 0.2705502135541759 0.0295414836578747 0.9764327341919106 1.0 1.0 7 O14974,P35611,Q13464 3 +Regulation of skeletal muscle adaptation 0.3444342204716138 0.0291798948548042 0.9767211159871034 1.0 1.0 3 Q08209 1 +Skeletal muscle adaptation 0.3444342204716138 0.0291798948548042 0.9767211159871034 1.0 1.0 3 Q08209 1 +Definitive hemopoiesis 0.2801175318315438 0.0291639444416897 0.9767338371614488 1.0 1.0 4 Q96JB5,Q13951,P55265 3 +Clathrin coat assembly 0.2660660070766029 0.0287395379771297 0.977072322634932 1.0 1.0 9 P53680,O00291 2 +Positive regulation of protein localization to cell cortex 0.3381201044386484 0.0282706955327528 0.9774462528315268 1.0 1.0 3 P11171,Q14980 2 +Regulation of insulin secretion 0.2494736654560522 0.0273737607877421 0.9781616262622226 1.0 1.0 23 Q8N183,P53985,Q8N5M9,Q16836 4 +Regulation of protein catabolic process in the vacuole 0.3280026109660598 0.0270483508175602 0.9784211697460374 1.0 1.0 3 P04062,Q07954 2 +Regulation of lysosomal protein catabolic process 0.3280026109660598 0.0270483508175602 0.9784211697460374 1.0 1.0 3 P04062,Q07954 2 +Positive regulation of tissue remodeling 0.3256212469458917 0.0267985697357804 0.9786203939950548 1.0 1.0 3 Q13464 1 +Positive regulation of connective tissue replacement 0.3256212469458917 0.0267985697357804 0.9786203939950548 1.0 1.0 3 Q13464 1 +Connective tissue replacement 0.3256212469458917 0.0267985697357804 0.9786203939950548 1.0 1.0 3 Q13464 1 +Regulation of connective tissue replacement 0.3256212469458917 0.0267985697357804 0.9786203939950548 1.0 1.0 3 Q13464 1 +Spermidine metabolic process 0.3227806788511808 0.0265179481866043 0.9788442180499936 1.0 1.0 3 Q96QD8,P49366 2 +Endosome to plasma membrane protein transport 0.2606139777922882 0.0264253149898637 0.9789181027556756 1.0 1.0 5 Q15904,Q14160,Q96QK1,P51149 4 +Negative regulation of cell morphogenesis involved in differentiation 0.3162532637075793 0.0259398095167592 0.979305347317081 1.0 1.0 3 O43707,Q9P258 2 +Regulation of lamellipodium morphogenesis 0.3162532637075815 0.0259398095167592 0.979305347317081 1.0 1.0 3 Q9BR76,Q92766 2 +Positive regulation of lamellipodium morphogenesis 0.3162532637075815 0.0259398095167592 0.979305347317081 1.0 1.0 3 Q9BR76,Q92766 2 +Negative regulation of multicellular organismal process 0.27337142252098 0.0258833293802117 0.9793503968201488 1.0 1.0 97 P35080,Q96G23,P49840,P00813,P49841,Q16850,Q9UNN8,P30536 8 +Fibroblast activation 0.3102499689225667 0.0254829152166527 0.9796697757448688 1.0 1.0 3 Q15418 1 +Hepatic stellate cell activation 0.3102499689225667 0.0254829152166527 0.9796697757448688 1.0 1.0 3 Q15418 1 +Regulation of dna damage checkpoint 0.2672329304148979 0.0254219972607158 0.9797183654999392 1.0 1.0 6 Q96QC0,P15927,Q13769,Q8N163,Q96FV9 5 +Regulation of myosin light chain phosphatase activity 0.3079045365798809 0.02532214983425 0.979798006581634 1.0 1.0 3 Q13464 1 +Positive regulation of smooth muscle cell migration 0.3058093994778149 0.0251864174744804 0.9799062708059912 1.0 1.0 3 Q96N67,P31949 2 +Anterograde dendritic transport 0.2996083550913911 0.0248252896208256 0.9801943190720132 1.0 1.0 3 Q14254,P33176 2 +Regulation of protein targeting to membrane 0.2671031729148632 0.024783320963012 0.9802277949164676 1.0 1.0 7 Q9GZY8,Q9NQG6,P27105 3 +Response to arsenite ion 0.2898172323759857 0.0243643849371019 0.980561956590014 1.0 1.0 3 Q9H2U1,Q96QD8 2 +Angiotensin activated signaling pathway 0.266395255982143 0.0241399711554904 0.9807409602313568 1.0 1.0 4 Q13464 1 +Activation of phospholipase d activity 0.2774151436031407 0.0239372615024972 0.9809026524094566 1.0 1.0 3 P18085,Q14344 2 +Response to bacterium 0.2565160804358257 0.0190171863542647 0.9848273951608292 1.0 1.0 57 P07948,Q96CV9,P08670,P04439,P17252,O43823,P30536,P14174,P61106,Q8WTV0,Q9UQB8 11 +Protein localization to synapse 0.2495781656865243 0.0180672038574553 0.985585241209714 1.0 1.0 11 Q9UQB8 1 +Response to angiotensin 0.2449660634016717 0.0174206852046815 0.9861010072518188 1.0 1.0 5 Q13464 1 +Regulation of intracellular transport 0.2882537091549409 0.0166320154363632 0.9867301834625946 1.0 1.0 113 Q9Y282,Q14978,P55786,Q9Y3B8,O00459,Q9GZY8,P12270,Q9H7Z3,P49840,P49841,P17252,Q9NPF5,P06493,Q9UII2,P50402 15 +Regulation of dna templated transcription in response to stress 0.2577456576693471 0.0163976636103209 0.9869171436684672 1.0 1.0 9 P09601,Q15418,Q9NYF8 3 +Er associated misfolded protein catabolic process 0.2561254491996096 0.0150878660116713 0.9879620813816152 1.0 1.0 6 P55072,Q92890,P46379,Q9NYU2,Q9BUN8 5 +Response to misfolded protein 0.2563767168083724 0.0145003961947148 0.988430763179628 1.0 1.0 9 Q13618,Q9NXW2,Q92890,P55072,P46379,Q9NYU2,Q9UNE7,Q9BUN8 8 +Trna aminoacylation for mitochondrial protein translation 0.2570389662034885 0.0134309260623897 0.9892839936348324 1.0 1.0 8 Q6PI48,Q9NP81,Q5JTZ9,Q9BW92 4 +Rrna 3 end processing 0.2526813180144864 0.012241723049048 0.9902327621348408 1.0 1.0 6 Q15024 1 +Regulation of lamellipodium organization 0.2405944919268266 0.0120977251589827 0.9903476473203244 1.0 1.0 18 Q12792 1 +Embryonic brain development 0.2287732433683369 0.0106071176656438 0.9915369032787628 1.0 1.0 5 P62995,Q9Y3C6 2 +Golgi to vacuole transport 0.2552605543022354 0.0100759800940264 0.9919606670809642 1.0 1.0 7 O14976 1 +Regulation of substrate adhesion dependent cell spreading 0.2342029151015091 0.0098046272153686 0.9921771646564228 1.0 1.0 16 Q92766,P60953,Q14185,P07237 4 +Positive regulation of microtubule polymerization or depolymerization 0.2340216322517173 0.0094662343161979 0.9924471505916244 1.0 1.0 16 Q16512,P51608,Q14008,P23396,P36404,P63000,Q9NWH9,Q15691,P0DMV9,P36405,Q14203,Q14980,Q7Z460,Q16625,Q9Y295 15 +Peptidyl threonine dephosphorylation 0.2250163291966004 0.0093402643006695 0.9925476556785888 1.0 1.0 5 P53041,Q96HS1,P49593,O15355 4 +Cellular response to hormone stimulus 0.2988150785358494 0.0087390410141248 0.9930273428499978 1.0 1.0 125 P25054,P07948,O00459,O15118,P49840,P09874,Q9Y4I1,P49841,O95831,Q13464,O75928,P42785,Q96HY6,P33121,O43823,P17252,Q9UQB8,O15173 18 +Regulation of endothelial cell development 0.2468166440638501 0.0077650635512346 0.9938044379403664 1.0 1.0 6 O14974,Q13464 2 +Branching morphogenesis of an epithelial tube 0.2358853235581166 0.00582423740682 0.9953529571672934 1.0 1.0 12 Q16512,P35222,O94813,Q14344,Q15648,Q96T37,Q9NWH9 7 +Response to temperature stimulus 0.2630373860282392 0.0057942748146121 0.9953768634536252 1.0 1.0 46 Q13217,Q96EY1,P07948,P12270,P49841,P17252,Q99543,P09601,Q14011 9 +Dendritic cell migration 0.2093403004572168 0.0051276554486039 0.9959087408129276 1.0 1.0 5 P27797,Q07021,Q4KMQ2,P60953 4 +Mitochondrial electron transport cytochrome c to oxygen 0.2401649072648881 0.0032254973832912 0.9974264298994616 1.0 1.0 6 P00403 1 +Gland morphogenesis 0.2435753298103986 0.0030274884723177 0.9975844173800084 1.0 1.0 10 Q15418 1 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f708979331beb20b022de1442f177daeabe83181 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activation of store operated calcium channel activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult heart development", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid translocation", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp catabolic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide antigen via mhc class ib", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Antral ovarian follicle growth", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome lysosome fusion", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "Bundle of his cell to purkinje myocyte signaling", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp catabolic process", "Camp mediated signaling", "Camp metabolic process", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate import across plasma membrane", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac right ventricle morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine secretion", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell differentiation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cholesterol", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hydroperoxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transmembrane transport", "Copper ion transport", "Copulation", "Coronary vasculature development", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Dehydroascorbic acid transport", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine secretion", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Double strand break repair via synthesis dependent strand annealing", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal cell differentiation", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil mediated immunity", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated inhibitory signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain dorsal ventral pattern formation", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactolipid biosynthetic process", "Galactolipid metabolic process", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center b cell differentiation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import across plasma membrane", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula formation", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell migration", "Hematopoietic stem cell migration to bone marrow", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Heparin biosynthetic process", "Heparin metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immature b cell differentiation", "Immune effector process", "Immune response", "Immune response inhibiting cell surface receptor signaling pathway", "Immune response inhibiting signal transduction", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Iodide transport", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte migration involved in inflammatory response", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphocyte migration into lymphoid organs", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Mast cell proliferation", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature b cell differentiation", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane fusion involved in viral entry into host cell", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Midgut development", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotactic protein 1 production", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Mucosa associated lymphoid tissue development", "Mucus secretion", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle atrophy", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immune response to tumor cell", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of behavior", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cell adhesion mediated by cadherin", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular extravasation", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of digestive system process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell apoptotic process", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of feeding behavior", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotactic protein 1 production", "Negative regulation of monocyte chemotaxis", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil activation", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of non canonical wnt signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to microtubule", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor recycling", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of thymocyte apoptotic process", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor 2 signaling pathway", "Negative regulation of toll like receptor 4 signaling pathway", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor mediated signaling pathway", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Olfactory nerve development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Penile erection", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet degranulation", "Platelet dense granule organization", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of b cell receptor signaling pathway", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle adaptation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cd8 positive alpha beta t cell differentiation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cell adhesion mediated by integrin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of granulocyte differentiation", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide mediated programmed cell death", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle adaptation", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immune response to tumor cell", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phospholipid translocation", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of platelet derived growth factor receptor signaling pathway", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of regulatory t cell differentiation", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secondary metabolite biosynthetic process", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of store operated calcium channel activity", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell differentiation in thymus", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor receptor signaling pathway", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Prepulse inhibition", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Proline transport", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein c linked glycosylation", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c activating g protein coupled receptor signaling pathway", "Protein kinase c signaling", "Protein linear polyubiquitination", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to non motile cilium", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Putrescine metabolic process", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinolinate metabolic process", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagic cell death", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of blood vessel remodeling", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cd8 positive alpha beta t cell differentiation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centromere complex assembly", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of eating behavior", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipid transporter activity", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic nuclear division", "Regulation of melanocyte differentiation", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of mucus secretion", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immune response to tumor cell", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil activation", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil degranulation", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non canonical wnt signaling pathway", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pancreatic juice secretion", "Regulation of pattern recognition receptor signaling pathway", "Regulation of penile erection", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phosphatidylinositol dephosphorylation", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigment cell differentiation", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of store operated calcium channel activity", "Regulation of store operated calcium entry", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 2 signaling pathway", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of voltage gated sodium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cycloheximide", "Response to cytokine", "Response to dexamethasone", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to inactivity", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle inactivity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to stimulus involved in regulation of muscle adaptation", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to yeast", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secondary palate development", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Semicircular canal development", "Semicircular canal morphogenesis", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Store operated calcium entry", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taurine transport", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Tolerance induction to self antigen", "Toll like receptor 2 signaling pathway", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula formation", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by trans synaptic complex", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urate transport", "Urea cycle", "Urea metabolic process", "Ureter development", "Urogenital system development", "Uronic acid metabolic process", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated cholesterol transport", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C3orf58", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COG4", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM162A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL19", "MRPL2", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL41", "MRPL44", "MRPL47", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS27", "MRPS28", "MRPS30", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM161A", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM41B", "TMEM43", "TMEM65", "TMEM70", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSPO", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13D", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFC3H1", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCC4", "ABCD3", "ABHD10", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACTN4", "ADA", "ADAR", "ADD1", "ADK", "ADNP", "ADSS", "AFG3L2", "AHCTF1", "AHCYL1", "AIFM1", "AKAP1", "AKAP8", "ALCAM", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALG1", "ALG11", "AMOT", "ANKLE2", "ANO6", "ANXA1", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP2S1", "APC", "ARF4", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARID1A", "ARL2", "ARL3", "ARL8B", "ARPC5", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V1D", "ATP6V1E1", "ATP7B", "ATPIF1", "ATRX", "AURKB", "BAG5", 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0000000000000000000000000000000000000000..8df3d11b86778509490034f60f37f865c2fce30f --- /dev/null +++ b/msigdb_gocc/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bb94c42d1d1b6f332bf628601bf5a0d4dcbae8c7611d5dcbb0973c2da7868210 +size 94221 diff --git a/msigdb_gocc/df_merge.tsv b/msigdb_gocc/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d9cd405757ae06256c0a548461932cd82ff2bc3a --- /dev/null +++ b/msigdb_gocc/df_merge.tsv @@ -0,0 +1,12 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Cyclin dependent protein kinase holoenzyme complex 2 9 2.6025575818297586 0.009253127509063 4.868932038834951 11.41504854368932 0.1735754773702774 0.6105535746219315 2.989026179248962 2.020541777670883 0.8517598041508873 0.3109255575757516 0.0017757260688105 0.0007818203448131 0.0058560324261939 0.063688713570506 0.2801972283088816 +Endoplasmic reticulum lumen 23 58 2.58891933710446 0.0096277644043429 18.07766990291262 59.737864077669904 0.9896277047863468 0.3946249358858228 7.513340007333169 6.273245958458151 1.4320597420402308 0.3846324865730224 0.247507013851479 0.0473127294122767 0.2259947926684591 0.0026907227290202 5.624167303575799e-07 +Microbody membrane 10 29 2.5426219561744388 0.0110024197767006 9.83980582524272 26.8373786407767 1.0322166739723002 0.3740701224912098 5.101262737371427 4.075770333088885 1.3138416014090577 0.3534887732287703 1.0 0.2406936845278361 0.4274740864709498 0.000423196822916 7.642967523267423e-05 +Protein kinase complex 2 22 2.4308803032171857 0.015062189609885 9.305825242718448 26.640776699029125 0.0834251211245744 0.6520727496615577 5.442877687662837 4.410610262977704 0.8513500824364756 0.3106562213180078 0.0094100688295897 0.0088678833523326 0.0554265344441834 0.3661388620186562 0.8135972508027685 +External side of plasma membrane 5 22 2.346521389183672 0.0189495785404232 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.1628913150338835 0.0919108957066336 0.0838856775027136 0.1145603052268967 0.2554949002325081 +Proteasome core complex 3 15 2.20782129726668 0.0272567328423631 5.325242718446602 14.563106796116504 1.2215341624098188 0.3078540255827756 2.4387733048296822 0.5516067072365743 1.1166106206832802 0.3218631020970666 1.0 0.0786913117950012 0.0005470061355849 0.00062382482254 0.0010053263520343 +Microbody 17 57 2.188693596122727 0.0286191177502477 14.5873786407767 55.157766990291265 0.5308798958236631 0.4622505798174944 6.656600193656261 6.967459933597681 1.141402376279513 0.3502304815174672 0.174112002762682 0.0172741819727463 0.0049705397344002 3.560774882692813e-06 4.916468519324637e-07 +Proteasome core complex beta subunit complex 3 7 2.067263917673097 0.0387092922542049 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 0.0424464003246627 7.149857972393559e-05 3.848915456526504e-05 0.0005688349419973 +Cell surface 19 77 2.032719818286332 0.0420808378783628 21.233009708737864 77.5995145631068 0.4772545566224628 0.498248600191797 7.455308766626032 8.832436895439663 1.3320096182828691 0.3812427248674431 0.4136953252188617 0.192349493051136 0.085737991117735 0.3545660620516488 0.1934406021394967 +Beta catenin destruction complex 1 7 2.019619445384193 0.0434228765574007 2.1601941747572817 5.230582524271845 0.3284788184930474 0.6000358755545291 1.4643226212126863 1.053305776459868 0.7717659205698326 0.3065244102773822 0.0198359893050149 0.0014481500629001 0.0057815105752346 0.0328731354880699 0.018020673376298 +Brush border membrane 2 8 2.007144432802372 0.0447342862796531 2.128640776699029 8.16504854368932 0.472235467278842 0.5365473731886248 1.5658538094317804 1.313463422670024 0.7591789093751276 0.2875902344219656 1.0 0.1135912525516411 0.02421661276018 0.0217985290060267 0.1188827437046941 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..46130f851df5ed4287934501e0215a95ee5e702e --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 904, + "title": "Average number of proteins per term", + "value": 28.077433628318584 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6a62183502aa5d7465d6f665ad641ce88d67633f --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..37a6cc032703cf5b8e0b7d8373c4a86f0c94f7e0 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,213 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cyclin dependent protein kinase holoenzyme complex 0.8797024282388476 2.6025575818297586 0.009253127509063 0.9997759783988772 0.4324429338320619 9 P06493,P24941 2 +Endoplasmic reticulum lumen 0.5305124236733599 2.5889193371044597 0.0096277644043429 0.999840850654662 0.4324429338320619 58 O75718,P07237,Q6P179,P13667,Q9Y680,Q9H173,Q14257,Q32P28,O15460,Q02818,O14975,O95881,P30101,Q13217,Q8NBS9,Q15084,Q8IXB1,O43852,Q07065,P13674,Q9NWM8,Q9BTV4,P07942 23 +Microbody membrane 0.6313303510136468 2.5426219561744388 0.0110024197767006 0.9999546594246664 0.4324429338320619 29 P56589,Q9BY49,Q9NR77,Q15067,O75381,Q9BTZ2,P33121,O14975,P28288,P39210 10 +Protein kinase complex 0.6423737942011541 2.4308803032171857 0.015062189609885 0.9999988995660132 0.4695248071495197 22 P06493,P24941 2 +External side of plasma membrane 0.6288715491405442 2.3465213891836716 0.0189495785404232 0.99999996917088 0.5038358529571352 22 P00813,P08183,O15439,P41440,P42892 5 +Proteasome core complex 0.6637633315914849 2.2078212972666797 0.0272567328423631 0.9999999999858616 0.587992782868726 15 Q99436,P28070,P49721 3 +Microbody 0.4928139640924631 2.188693596122727 0.0286191177502477 0.9999999999960176 0.587992782868726 57 P56589,P34913,P08670,Q9BY49,Q9NR77,Q15067,Q9Y4I1,O75381,P33121,O14975,P28288,Q15126,Q8N4Q0,Q9GZY8,P48735,P39210,O15254 17 +Proteasome core complex beta subunit complex 0.7861032878068632 2.067263917673097 0.0387092922542049 0.9999999999999996 0.6541656869087281 7 Q99436,P28070,P49721 3 +Cell surface 0.441676397532421 2.032719818286332 0.0420808378783628 1.0 0.6629474556853516 77 P07237,Q9HDC9,P08183,P41440,Q8WTV0,P13667,P06576,Q13740,O15439,Q9UNN8,P14174,P42892,P30101,Q13685,P00813,P04439,P09525,Q8IWT6,Q9UII2 19 +Beta catenin destruction complex 0.7750770063892343 2.019619445384193 0.0434228765574007 1.0 0.6629474556853516 7 P49840 1 +Brush border membrane 0.7580037155694019 2.007144432802372 0.0447342862796531 1.0 0.6629474556853516 8 Q14728,P41440 2 +Condensed nuclear chromosome 0.5908953012958046 1.9037226725539225 0.0569463120164459 1.0 0.7088677728594845 18 O60885,Q92791,Q92878,Q8N3U4,P16104,Q9HD42,P53350,Q9NQS7,Q9H6R4 9 +Proton transporting two sector atpase complex 0.5445249830274852 1.8025368879459391 0.0714609764470968 1.0 0.7434427485192011 22 P00846,P06576,Q9Y5K8,Q8N511,P36543 5 +Postsynaptic density membrane 0.7604667792649601 1.7996819690152892 0.0719108697944839 1.0 0.7434427485192011 6 Q99720 1 +Proton transporting v type atpase complex 0.6543377823040004 1.7839882538581189 0.0744255738471451 1.0 0.7475635417535463 11 Q9Y5K8,Q8N511,P36543 3 +Synaptonemal structure 0.7844516113648181 1.750953209820024 0.079953970087764 1.0 0.7640861992254774 5 Q92791 1 +Intrinsic component of peroxisomal membrane 0.7815874549060983 1.7392708889619926 0.0819871253593709 1.0 0.7640861992254774 5 P56589,O14975 2 +Basal part of cell 0.4644312251978 1.7268499122658258 0.0841946218477285 1.0 0.7653509442720737 52 Q92796,Q6P4Q7,O15439,Q99808,P42785,P30825,P41440,P53985 8 +Spindle midzone 0.5578857081383295 1.7038222722575789 0.0884142957088403 1.0 0.7685242626999195 18 Q96GD4,Q9H0H5,Q53HL2,P53350,Q9NQS7 5 +X chromosome 0.7637036316832342 1.6660865034915706 0.0956961863074259 1.0 0.8041888005405695 5 P24941 1 +Basolateral plasma membrane 0.4794461508682061 1.6641840567622606 0.0960756531619264 1.0 0.8041888005405695 45 Q92796,Q6P4Q7,O15439,Q99808,P30825,P41440,P53985 7 +Intrinsic component of synaptic vesicle membrane 0.6772960341551242 1.6431085608768785 0.1003604739321486 1.0 0.8056316737505647 8 P61020,O15126,P20339,Q86Y82 4 +Intrinsic component of mitochondrial inner membrane 0.4959281495672639 1.634540943532329 0.1021453164572614 1.0 0.8099944392751258 35 Q99595,O60830 2 +Centriolar satellite 0.529669359785867 1.6079545321456918 0.1078451372033997 1.0 0.8348152424163777 20 P53350,Q9UPT5,Q7Z4H7,P41440 4 +Apical plasma membrane 0.463779472909414 1.602843336983446 0.1089692462446156 1.0 0.8348152424163777 48 P36551,P08183,O15439,Q8TAD4,Q99808,P30825,P41440,P53985,Q16625 9 +Nuclear inner membrane 0.5013350916943939 1.5655786921478017 0.1174472815685288 1.0 0.8396517462087647 23 Q14728,Q8IXM6,Q99720,Q14739,O75844,P50402 6 +Mitotic spindle pole 0.5926946613484065 1.5641762395040149 0.1177761855622634 1.0 0.8396517462087647 12 Q9UQE7,Q96GD4,Q8WVM7,P53350,Q9P287,Q14980,Q8N3U4 7 +Anchored component of membrane 0.6483512673438963 1.5097473239087025 0.1311079108010402 1.0 0.8460683447016083 8 P61020,P20339,P36551 3 +Paraspeckles 0.691175925029571 1.502890479415179 0.1328672884995256 1.0 0.8460683447016083 6 Q8WXF1,Q15233,Q16630 3 +Ciliary basal body 0.5350189719914267 1.501122270460058 0.1333239396074361 1.0 0.8460683447016083 16 P49454,Q9UPT5,P28070 3 +External side of apical plasma membrane 0.9435562805872716 1.4927425399971663 0.1355045933515239 1.0 0.8465423389424224 2 P08183 1 +Nuclear outer membrane 0.6137692496021693 1.4861982939194842 0.1372266786897702 1.0 0.8465423389424224 10 Q99720,Q6NUM9,P50402,Q9UBM7 4 +Apical part of cell 0.4186472428878497 1.473554486536261 0.1406015833306619 1.0 0.8465423389424224 57 P36551,P08183,O15439,Q8TAD4,Q99808,P30825,P41440,P53985,Q16625 9 +Sin3 type complex 0.6829218767095576 1.4671363138201134 0.1423389773443011 1.0 0.8465423389424224 6 Q9H0E3 1 +Endoplasmic reticulum chaperone complex 0.6754396307757751 1.434668512985228 0.1513815808522971 1.0 0.8541009850350633 6 Q8IXB1,Q15084 2 +Pigment granule 0.3845570310524726 1.3840507015534005 0.1663429305076205 1.0 0.8817281072309557 63 P30101,P49755,P07237,O14773,Q9Y4I1,Q15084,P51151,P08133,P20339,P41440,O43852,P50995,P13667 13 +Lipid droplet 0.4664242483896526 1.3736217523038867 0.1695591402957481 1.0 0.883799039581763 28 Q8NBX0 1 +Midbody 0.3831573500323026 1.3670904046817205 0.1715969704925359 1.0 0.883799039581763 78 Q96GD4,Q9H0H5,Q8NBX0,Q9UPT5,P53350,P06493,O60645,P53990,P50995,Q6DKK2 10 +Endoplasmic reticulum golgi intermediate compartment membrane 0.4654483968454063 1.3655919658875502 0.1720670696530866 1.0 0.883799039581763 26 O15260,P56962,Q8N511,P49755 4 +Endoplasmic reticulum golgi intermediate compartment 0.4344611029126745 1.323261417811901 0.1857484575707797 1.0 0.9065341499705516 47 Q9Y282,P07237,P56962,P80303,Q15084,Q8N511,O15260,P53990,P49755 9 +Mhc class i peptide loading complex 0.7504281808781678 1.3209398922165112 0.1865214069629674 1.0 0.9065341499705516 4 P30101 1 +Mitotic spindle microtubule 0.6382977721224802 1.2729005452838096 0.203053335748061 1.0 0.931960694604 6 Q9H6D7,Q7Z4H7 2 +Haus complex 0.7305779921683166 1.2431567862677892 0.2138100634306523 1.0 0.9335695047623064 4 Q9H6D7,Q7Z4H7 2 +Nurd complex 0.5906701340010594 1.2410010486850829 0.2146053614754925 1.0 0.9335695047623064 8 Q8WXI9,Q12873,O95983,Q86YP4 4 +Outer kinetochore 0.6304101621490747 1.2384692701027702 0.2155421096507668 1.0 0.9335695047623064 6 P53350 1 +Pericentric heterochromatin 0.5540318559518791 1.1909367492538023 0.2336784163738787 1.0 0.9457439943274376 10 P45973,P46100,Q9NQS7 3 +Pronucleus 0.6481559563156 1.18633198286589 0.2354912209259181 1.0 0.9457439943274376 5 P49454,O43823 2 +Spindle pole centrosome 0.5857178418909201 1.169737028989435 0.2421068117799967 1.0 0.9457439943274376 7 Q9Y5Y2,Q96GD4 2 +Intrinsic component of nuclear inner membrane 0.5840961507464894 1.162306118469609 0.2451111421878447 1.0 0.9457439943274376 7 Q9BTV4,Q14739,Q9UH99 3 +Anchored component of synaptic vesicle membrane 0.6417374265186315 1.159562481178663 0.2462269839354744 1.0 0.9457439943274376 5 P61020,Q15286,P20339,P51149 4 +Exocyst 0.6096629864290454 1.1479011725657595 0.2510093640991189 1.0 0.9457439943274376 6 Q9UPT5 1 +Mitotic spindle 0.3935115921465755 1.128322849049995 0.2591835971828442 1.0 0.9457439943274376 54 Q96GD4,Q9H0H5,Q7Z4H7,Q8WVM7,Q9H6D7,P53350,P06493 7 +Mitochondrial large ribosomal subunit 0.4302282755365269 1.121670425854125 0.2620025954534322 1.0 0.9457439943274376 34 Q7Z7F7,Q9NYK5,Q9NQ50,Q7Z7H8,Q567V2 5 +Golgi lumen 0.6321699081041443 1.1196964765864692 0.2628431270202849 1.0 0.9457439943274376 5 Q9NX62 1 +Protein lipid complex 0.8611837259071837 1.1182965057238805 0.2634403788186565 1.0 0.9457439943274376 3 Q9UHG3 1 +Integral component of lysosomal membrane 0.8479608482871086 1.1159775932606353 0.2644317258917734 1.0 0.9457439943274376 2 O15118 1 +Postsynaptic specialization intracellular component 0.6310424912238329 1.1150024757351018 0.2648493608107223 1.0 0.9457439943274376 5 P07948,O60716,Q9UQB8 3 +Cis golgi network 0.5067288890410814 1.106591230888575 0.2684707003466318 1.0 0.9457439943274376 12 Q14789,O95249,Q8TBA6,O00461,P49755 5 +Postsynaptic endosome 0.8529416703797854 1.089062995015408 0.2761261069870773 1.0 0.9457439943274376 3 Q86Y82 1 +Myofilament 0.6904995102840389 1.0865473570535085 0.2772369009920032 1.0 0.9457439943274376 4 P67936,Q9NYL9,P06753 3 +Striated muscle thin filament 0.6904995102840389 1.0865473570535085 0.2772369009920032 1.0 0.9457439943274376 4 P67936,Q9NYL9,P06753 3 +Dendritic shaft 0.6213700441771114 1.0747725348775248 0.2824765797744899 1.0 0.949117680055586 5 Q9UQB8 1 +Azurophil granule membrane 0.4290894845867971 1.0630915302504942 0.2877404450456133 1.0 0.9571895127033888 23 P42785,O15260 2 +Myosin ii complex 0.6842964413973233 1.0624217938484384 0.288044244256783 1.0 0.9571895127033888 4 Q7Z406,P60660,P35580 3 +Chromosome passenger complex 0.8394255874673799 1.041312178183088 0.2977306864948716 1.0 0.9595382291567344 3 Q96GD4,Q9NQS7 2 +Neurofilament 0.8390997867613098 1.0401643687116502 0.2982635424701796 1.0 0.9595382291567344 3 Q16352 1 +Mrna cleavage and polyadenylation specificity factor complex 0.5211328906385772 1.0279640801693797 0.3039667244969473 1.0 0.9602039248919868 10 Q8N684,Q6UN15,Q16630 3 +Outer mitochondrial membrane protein complex 0.4586783272933344 1.02647582085127 0.3046673550447916 1.0 0.9602039248919868 15 Q9NS69,Q8IWA4 2 +Intrinsic component of mitochondrial membrane 0.3912846718512707 1.0060005967933967 0.3144152829824469 1.0 0.970073091522635 50 P50336,Q9Y4W6,Q99595,Q9NX63,Q8IWA4,Q9GZY8,Q9UH62,O60830 8 +Proton transporting two sector atpase complex catalytic domain 0.4881709041028208 0.9358979141848652 0.3493257512259897 1.0 0.9840111944539928 11 P06576,P36543 2 +Brush border 0.4063160990241477 0.9313329344635276 0.3516813706724322 1.0 0.9840111944539928 30 Q14728,P41440 2 +Wnt signalosome 0.8054461154277366 0.9225992680464532 0.3562160772710341 1.0 0.9840111944539928 3 P49841 1 +Golgi medial cisterna 0.803851174934729 0.9170839360032976 0.3590986581289153 1.0 0.9840111944539928 3 O95249,P04439 2 +Myosin complex 0.4983555163218275 0.9158518116713844 0.3597446242208262 1.0 0.9840111944539928 10 O00159,Q9Y4I1,Q7Z406,P60660,P35580 5 +Cleavage furrow 0.4417308847669805 0.9148009533252568 0.3602961342525128 1.0 0.9840111944539928 14 Q9UHB6 1 +Tim23 mitochondrial import inner membrane translocase complex 0.5285901000176305 0.9091172156825283 0.3632882561094981 1.0 0.9862239745435024 7 Q99595 1 +Centriole 0.4158863652176232 0.8713780022786176 0.383547792777686 1.0 1.0 20 O00139,O75695,Q13464,O95684,P53350,Q9Y5Y2 6 +Intrinsic component of plasma membrane 0.3474189401493395 0.8500096878280216 0.3953197001280224 1.0 1.0 87 P36551,Q92796,O15118,P53985,Q8TDW0,Q9NR28,Q8TAD4,Q99808,O95864,Q9UNN8,P30825,P41440,Q8WTV0,P98172 14 +Proton transporting atp synthase complex 0.4705857089999932 0.8467230533527105 0.3971495059576637 1.0 1.0 11 P00846 1 +Transcription regulator complex 0.3247951137197874 0.8372432132328514 0.4024558718429039 1.0 1.0 68 P45973,P29084,P23246,P07305,P09874,Q13185,Q15233,Q99729,Q9Y5Q8,Q96PK6,Q8WXI9,Q9NY61,Q9H2P0,Q6P1K2,O15446,P24941,Q9Y5Q9,Q12873 18 +Oligosaccharyltransferase complex 0.5004344266699894 0.8213063540144745 0.4114717893326598 1.0 1.0 8 P04843,Q8TCJ2,Q9H0U3,P04844,P39656,P46977 6 +Lamellar body 0.7683523654159785 0.8136616887792332 0.4158387873770457 1.0 1.0 2 Q07065 1 +Gamma secretase complex 0.7657422512234775 0.8040934370134988 0.4213430145991057 1.0 1.0 2 P49755 1 +H4 h2a histone acetyltransferase complex 0.4615904607588901 0.8015177749154553 0.4228319580202955 1.0 1.0 11 Q9NV56,Q9UBU8 2 +H4 histone acetyltransferase complex 0.4213126766984357 0.7991610002478753 0.4241970625640368 1.0 1.0 14 Q9NV56,Q9UBU8 2 +Iswi type complex 0.5026143790849691 0.7925478944992702 0.4280412768233235 1.0 1.0 7 Q12830,O60264,Q96T23,Q9NRL2,P28370,Q9UIG0 6 +Dna packaging complex 0.3853002634074057 0.7790180570221561 0.4359690779922474 1.0 1.0 29 P10412,O95619,Q9NV56,P07305,P16403,Q9UBU8,Q9NPF5,Q8NB78,P84243 9 +Postsynaptic density intracellular component 0.6098625123775627 0.7783820224242523 0.4363438338342278 1.0 1.0 4 O60716,Q9UQB8 2 +Filopodium membrane 0.7579119086460016 0.7755618643263256 0.4380077247121861 1.0 1.0 2 P46939 1 +Protein acetyltransferase complex 0.3959039420316046 0.7703529628724562 0.4410905472656756 1.0 1.0 21 Q9NV56,Q9NPF5,Q9UBU8 3 +Integral component of synaptic vesicle membrane 0.7573619704049411 0.7593213585775721 0.4476603438628683 1.0 1.0 3 Q86Y82 1 +Prespliceosome 0.4859767961357923 0.7556368565853798 0.4498669518278846 1.0 1.0 8 Q9Y383,O75400,O75533,Q15459,Q15428 5 +Centriolar subdistal appendage 0.7517128874388207 0.7531679862724827 0.4513489743353966 1.0 1.0 2 O00139 1 +Transferase complex transferring phosphorus containing groups 0.3154080460466228 0.7451506818246851 0.4561806333017231 1.0 1.0 67 P06493,P24941,Q14004,O00459 4 +Contractile ring 0.5994123408423149 0.7397475381906984 0.4594531970533075 1.0 1.0 4 P46939,P35579,Q14118 3 +Schaffer collateral ca1 synapse 0.4016577085709307 0.7222847000341213 0.4701194575719021 1.0 1.0 17 P35080,O14936,Q16352,Q9UQB8 4 +Intrinsic component of mitochondrial outer membrane 0.4446593526965147 0.7174324155934746 0.4731073241563122 1.0 1.0 11 O96008,P57105,Q8IWA4,Q8IXI2,Q8IXI1,Q9GZY8,Q9UH62 7 +Dendrite cytoplasm 0.444388826164229 0.7161012672877883 0.4739288213286552 1.0 1.0 11 Q00577,Q8N2K0,P23246,Q9UQB8 4 +Proton transporting v type atpase v1 domain 0.4852108103701033 0.7157482365426083 0.4741468201529408 1.0 1.0 7 P36543 1 +Secretory granule membrane 0.3184082521812135 0.7146398755572161 0.4748315983368996 1.0 1.0 72 P61020,P42785,O60645,Q5T9A4,O75131,O95721,Q13636,O15439,P30519,O14975,O15260,P49755,P51149,O15126,Q8TAD4,Q92542,P27105,Q6IAA8,Q9NQX7,P61106,P20073,Q96JJ7,Q07065,Q9Y5K8,Q93050 25 +B wich complex 0.4846405228758188 0.713253890111987 0.475688664578856 1.0 1.0 7 P35659,O75533,O60264,Q9BQG0,Q9NY93,Q9UIG0 6 +Lateral element 0.7393148450244613 0.7089344035977152 0.4783651843371228 1.0 1.0 2 Q9NQS7 1 +Proteasome complex 0.3630805785496516 0.706368390299133 0.4799590729666612 1.0 1.0 47 Q99436,O43396,P28070,P49721 4 +Npbaf complex 0.4739888777544079 0.7018500289273543 0.4827726952686673 1.0 1.0 8 O14497,Q969G3 2 +Nbaf complex 0.4703547479451965 0.6856834923374847 0.4929127186406119 1.0 1.0 8 O14497,Q969G3,Q92785,Q96GM5 4 +Microtubule organizing center attachment site 0.7274288844551813 0.6616664352351972 0.5081850202120186 1.0 1.0 3 Q8WXH0 1 +Er membrane insertion complex 0.7199525311216088 0.6378795534116785 0.5235520885209022 1.0 1.0 3 Q7L5D6 1 +Copi coated vesicle 0.4159659747836982 0.6333342528485969 0.5265153897369856 1.0 1.0 12 Q8N511 1 +Organellar ribosome 0.3428411802480558 0.5801711765121766 0.5617991889542933 1.0 1.0 50 Q7Z7F7,Q9NYK5,Q9NQ50,Q7Z7H8,Q567V2 5 +Nuclear chromosome 0.3220398833756548 0.573590106739235 0.5662452080811258 1.0 1.0 87 Q9H0E3,Q92791,Q9Y619,Q9UBU8,P53350,P46100,Q969G3 7 +Cdc73 paf1 complex 0.4944737166659222 0.5678668003360646 0.570125416716321 1.0 1.0 5 Q92541,Q8N7H5 2 +Outer membrane 0.3159975924444043 0.5672102756288778 0.5705713275318653 1.0 1.0 82 Q9NS69,Q6NUM9,Q9Y6C9,P21796,Q92667,Q9NX63,Q8IWA4,Q5VT66,Q99536,Q99720,P33121,P30536,Q9UBM7,Q9GZY8,P09601,Q9UH62,O43169,P50402 18 +Female pronucleus 0.5508424172421625 0.5668043473887399 0.5708471166179132 1.0 1.0 4 O43823 1 +Proton transporting v type atpase v0 domain 0.6956388097839166 0.5624747749545791 0.5737925854206964 1.0 1.0 3 Q93050 1 +Vacuolar proton transporting v type atpase v0 domain 0.6956388097839166 0.5624747749545791 0.5737925854206964 1.0 1.0 3 Q93050 1 +Pml body 0.3495623543485684 0.5550880969427001 0.5788344040003075 1.0 1.0 24 P45973,P49959,O75928,P46100,Q9UBW7,Q12873,P80723 7 +Microtubule associated complex 0.345808554721353 0.5521673468616958 0.5808337038297209 1.0 1.0 46 Q96GD4,Q9NSK0,O00139,P49354,O95793,Q96S59,P12270,Q7Z4H7,Q53HL2,Q96CS2,Q9H6D7,Q9NQS7,O75935 13 +Myosin filament 0.6840731070496135 0.527766517755227 0.5976613988098085 1.0 1.0 3 Q7Z406,P35580 2 +Condensed chromosome centromeric region 0.3021750720975366 0.5146705155727835 0.6067832802249649 1.0 1.0 74 O75151,Q12769,Q96DE5,Q9BW27,Q9HD42,O75935,P45973,P25054,Q9NQS7,P46100,Q96GD4,Q8WYP5,P49454,P12270,Q96DY7,Q13185,P53350,Q6P1K2,Q92674 19 +Prp19 complex 0.4114957560653413 0.507480554030497 0.6118176773279942 1.0 1.0 10 Q9BZJ0,Q9P013,O75934,Q9HCS7 4 +Condensed chromosome 0.3353653133040137 0.504832564993888 0.6136764412272151 1.0 1.0 106 O75151,Q12769,Q92791,Q96DE5,O43823,Q9BW27,Q9HD42,P24941,O75935,P45973,P25054,P46100,Q9NQS7,Q9H6R4,Q96GD4,Q8WYP5,P49454,P12270,Q96DY7,Q13185,P53350,Q8NFH4,Q96MG7,Q8WVM7,Q6P1K2,Q92674 26 +Cell division site 0.3600330058578647 0.4978914136751257 0.6185605795581861 1.0 1.0 18 Q9UHB6 1 +Brca1 c complex 0.673466564054146 0.4966651779318201 0.6194251822910022 1.0 1.0 3 P49959 1 +Flemming body 0.3568792483640743 0.4928817042631415 0.6220961754302787 1.0 1.0 19 P53990,Q9UPT5 2 +Side of membrane 0.2926100839865181 0.4852058987219848 0.6275302982028008 1.0 1.0 68 Q9UBI6,P24666,P07948,P07237,Q9H0H5,P08183,P00813,O15439,P04439,Q9NR28,P20339,P41440,P42892 13 +Extrinsic component of cytoplasmic side of plasma membrane 0.3534077071540332 0.4734212857226186 0.6359126467195237 1.0 1.0 19 Q9UBI6,P07948,O00291,Q9H0H5,Q9BSJ8 5 +Endopeptidase complex 0.3252986633029152 0.4638132159624698 0.6427815738525142 1.0 1.0 52 Q99436,O43396,P28070,P49721 4 +Ubiquitin conjugating enzyme complex 0.5196743118181576 0.4634626268820446 0.6430327974599575 1.0 1.0 4 Q5VTR2 1 +Collagen containing extracellular matrix 0.3394685987041122 0.4619370359986399 0.6441264737928916 1.0 1.0 29 P20073,Q32P28,P09525,P08133,P07942,P50995 6 +Cell pole 0.658942558746742 0.4552961538035345 0.6488961929254577 1.0 1.0 3 P08195,Q9BTU6 2 +Intrinsic component of organelle membrane 0.3542748803264486 0.4497545051605219 0.6528874653696375 1.0 1.0 131 Q9Y282,Q99595,P61020,Q9UBM7,Q15629,O60830,Q9Y4W6,Q9NX63,O15118,O14975,Q9BSJ8,Q14739,O75844,Q9GZY8,P42892,Q6ZRP7,P50336,P30101,P56589,Q86Y82,O15126,P04439,Q8IWA4,Q9UM00,Q86XL3,Q9NPA0,Q8IWT6,Q8WVX9,Q86UP2,P20339,Q9BTV4,Q9UH62,Q96NB2 33 +Cell tip 0.6587275693311523 0.4449307442150079 0.6563698039114374 1.0 1.0 2 Q9BTU6 1 +Transcription elongation factor complex 0.3498070867444696 0.442292298577924 0.6582777032104752 1.0 1.0 18 Q14004 1 +Spindle microtubule 0.3375296833415594 0.440012011776366 0.6599284075777336 1.0 1.0 32 Q96GD4,P06493,P53350 3 +Protein complex involved in cell adhesion 0.6494874929839308 0.4291748823089212 0.6677959606656714 1.0 1.0 3 P07948 1 +Euchromatin 0.3304315506915587 0.425687756870554 0.6703353844709103 1.0 1.0 25 O15164,P07305,Q13185,P38159,P16402,Q8N7H5,P16403,Q9NQT4 8 +Histone deacetylase complex 0.3321868065031839 0.4245565658826528 0.6711599614530317 1.0 1.0 27 Q9H0E3,O75446,Q8WXI9,Q9UBU8,Q9NPF5,Q12873 6 +Chromosome telomeric region 0.2943177497900363 0.4215414630998539 0.6733597407199445 1.0 1.0 75 P45973,Q9UBD5,Q9Y619,Q92878,P09874,P22626,Q9NYB0,Q13185,P49959,Q00577,Q8WXI9,P06493,P24941,P46100,P84243 15 +Recycling endosome 0.3347283847196214 0.4178061656222118 0.6760888426030753 1.0 1.0 35 P30101,Q8N1B4,O15400,Q96CV9,Q86Y82,O14773,P04439,Q9Y4I1,Q96JG6,P61106 10 +Extrinsic component of postsynaptic specialization membrane 0.6489396411092936 0.4163594336918514 0.6771470080687767 1.0 1.0 2 P52292 1 +Vesicle tethering complex 0.3429831886971636 0.4162447947207724 0.67723088433821 1.0 1.0 19 Q8N1B4,P60953,Q9Y296,Q9UPT5,Q9Y2V7,O60645 6 +Lateral plasma membrane 0.3378829661341322 0.4007956580452811 0.6885705758879048 1.0 1.0 20 P53985,Q5T2T1,P25054 3 +Centrosome 0.3625071786520668 0.3876222789757663 0.698295579305622 1.0 1.0 147 P28074,P55081,P41440,Q6DKK2,P06493,P24941,P50402,O43805,Q7Z4H7,P49841,Q9UNN8,Q12873,Q96GD4,Q15004,Q8TD16,P49454,P53350,Q9Y5Y2,P53985,Q5VU43,Q9Y5K8,O75934,Q9UPT5,Q9H6D7,Q9NY27,P53990 26 +Chromocenter 0.4212833861846401 0.3786572893410379 0.7049423737094891 1.0 1.0 6 Q96GD4,Q9NQS7,Q53HL2 3 +Nuclear periphery 0.2889357167972774 0.3486927946229782 0.7273199542237254 1.0 1.0 62 O95239,P08670,Q9Y6X9,O14936,P49790,Q15233,Q8N1F7,P20700,O43823,Q9HD42,Q99848,Q9UQE7,O75400,P80723,O95619,Q8WYP5,P49454,P23246,P12270,O60870,P22626,Q5BKZ1,Q8WXF1,P52272,Q8WVM7,Q14980,Q8N3U4 27 +Cluster of actin based cell projections 0.3240302817825248 0.3471622450503631 0.7284694330564623 1.0 1.0 35 Q14728,P41440 2 +Distal axon 0.2974767384437815 0.3345332876458685 0.7379771764237215 1.0 1.0 58 O15511,Q9Y4I1,O75494,Q8N5V2,Q99720,Q9UPT5,P20339,Q9UKA9,O60645 9 +Nuclear inclusion body 0.382223024996547 0.3255195441083481 0.7447878933181735 1.0 1.0 8 O60934,P12270,P52948,P49790 4 +Zymogen granule 0.4702176467984151 0.3166402296388867 0.7515166064299372 1.0 1.0 4 P49755 1 +Peptidase complex 0.2943550747888671 0.3079805019616909 0.7580971688854297 1.0 1.0 58 Q99436,O43396,P28070,P49721 4 +Replication fork 0.317112836712177 0.3069354271371491 0.7588925227835217 1.0 1.0 33 Q9NPF5,Q9Y6I9,P49959,P41440 4 +Preribosome large subunit precursor 0.3177114571359017 0.3057179774864072 0.7598193842083325 1.0 1.0 21 Q14137,Q9H9Y2,O95478,Q9UKD2,Q99848,Q9Y3B9,Q969S3,Q9BXY0 8 +Tight junction 0.3133219616420486 0.2989284734182694 0.7649946212134813 1.0 1.0 29 Q9NR77,Q16625,Q92796 3 +Post mrna release spliceosomal complex 0.3797948180730604 0.296850834079429 0.7665803937232982 1.0 1.0 7 Q9BZJ0,Q9P2K5,Q9HCS7 3 +Swi snf complex 0.3483039893753056 0.2873232265683049 0.7738648398618042 1.0 1.0 11 O14497,Q969G3 2 +Early phagosome 0.4558253762364792 0.2787264805474285 0.7804547389980228 1.0 1.0 4 P20339 1 +Presynaptic active zone cytoplasmic component 0.5869484844816517 0.2750037220843853 0.783313378713757 1.0 1.0 3 O60716 1 +Specific granule membrane 0.3106026083787022 0.2485498324880136 0.8037090186367513 1.0 1.0 18 O15126,Q07065,Q9Y5K8,P30519,O14975,Q6IAA8 6 +Catalytic step 1 spliceosome 0.3796145050637032 0.245697759630923 0.8059162066033585 1.0 1.0 6 P38919,O75643,Q9Y5S9,Q9NW64,Q9UMS4 5 +Recycling endosome membrane 0.3030736065657647 0.2428970080684123 0.8080851833922407 1.0 1.0 22 P30101,Q96CV9,Q86Y82,P04439,P61106 5 +Nurf complex 0.5610313315926946 0.2218765220212898 0.8244100077308854 1.0 1.0 3 O60264,P28370 2 +Nuclear pore nuclear basket 0.3552110741102247 0.2179443349002075 0.8274724830795601 1.0 1.0 7 Q13257,P12270,Q8NFH5,P49790 4 +Cohesin complex 0.383575809042352 0.2158289669031459 0.8291210680911432 1.0 1.0 5 Q9UQE7,Q8N3U4,Q8WVM7 3 +Catalytic step 2 spliceosome 0.2620241923991105 0.1959240281184462 0.8446696300143746 1.0 1.0 67 Q9UKM9,P07910,P17844,P51991,P31943,O75533,O43390,Q9HCS7,Q9UQ35,O43290,Q9P013,Q99459,P22626,P61978,Q9Y3C6,Q9BZJ0,P38159,P52597,O75934,P09651,Q14331,Q07955 22 +Host cellular component 0.4198498204374775 0.1950329052524222 0.8453671875612683 1.0 1.0 4 P49790,O00505,P52292 3 +Exon exon junction complex 0.3749183540169831 0.1948373245933546 0.845520301396979 1.0 1.0 5 Q92900,Q9Y5S9,P38919,Q9BZI7 4 +Rna polymerase iii transcription regulator complex 0.4177864054002074 0.1907407748538638 0.848728691409961 1.0 1.0 4 Q9Y5Q8,Q9Y5Q9 2 +Transcription factor tfiiic complex 0.4177864054002074 0.1907407748538638 0.848728691409961 1.0 1.0 4 Q9Y5Q8,Q9Y5Q9 2 +Mitochondria associated endoplasmic reticulum membrane 0.3261442150701069 0.1820459975942268 0.8555466281141062 1.0 1.0 10 Q96N66 1 +Intrinsic component of golgi membrane 0.3131512082461892 0.1438271071537545 0.8856369970064699 1.0 1.0 10 Q9Y282,Q6ZRP7 2 +Origin recognition complex 0.339292221685734 0.1417017075654665 0.8873156261112036 1.0 1.0 6 Q9Y619 1 +Cortical endoplasmic reticulum 0.512222896008345 0.1408725644575661 0.88797061636725 1.0 1.0 3 P50402 1 +Chromosome centromeric core domain 0.5216965742251102 0.1405015982672323 0.8882636897824878 1.0 1.0 2 P62805 1 +Smooth endoplasmic reticulum 0.3028242867301917 0.1352352442606645 0.8924258821492306 1.0 1.0 11 Q13217 1 +Nuclear membrane 0.294722711520071 0.1213512131855988 0.903412857448854 1.0 1.0 106 Q6NUM9,Q9BTX1,Q9H2V7,Q99720,Q9BVC6,Q9BW27,Q9UBM7,Q9H4L5,Q9BW91,Q9Y5Q9,P50402,Q8IY37,Q14739,O75844,Q96T37,Q6ZRP7,Q14728,O95619,Q8WYP5,P12270,A8CG34,Q13185,P09525,Q8IXM6,P62995,Q99543,Q9BTV4,P67809 28 +Intrinsic component of postsynaptic density membrane 0.505709624796067 0.1195685653547815 0.904824922246656 1.0 1.0 2 Q15375 1 +Ptw pp1 phosphatase complex 0.3771993255161123 0.1180729500874173 0.9060098562047778 1.0 1.0 4 O14974,Q6UXN9 2 +Hippocampal mossy fiber to ca3 synapse 0.3344219464402364 0.1121458028009657 0.9107078010742076 1.0 1.0 5 Q15375,O60716,Q96EV8,P63104 4 +Neuron projection terminus 0.2742638340081263 0.1101734677822557 0.91227180379936 1.0 1.0 16 O75494,P20339 2 +Endosome lumen 0.4952691680260823 0.1075043261723333 0.914388893425374 1.0 1.0 2 Q9UIQ6 1 +Multimeric ribonuclease p complex 0.4923327895595309 0.1043329797830877 0.9169051066397962 1.0 1.0 2 Q99575 1 +Nucleolar ribonuclease p complex 0.4923327895595309 0.1043329797830877 0.9169051066397962 1.0 1.0 2 Q99575 1 +Ribonuclease mrp complex 0.4923327895595309 0.1043329797830877 0.9169051066397962 1.0 1.0 2 Q99575 1 +Axolemma 0.4807441253263715 0.1019590108607691 0.9187892100666092 1.0 1.0 3 Q9Y2J2,O94832 2 +Cell body membrane 0.4900489396410957 0.1019323713225196 0.9188103551771338 1.0 1.0 2 P20020 1 +Ciliary membrane 0.3163776080866888 0.0949510123565437 0.9243537375161708 1.0 1.0 6 O14936 1 +Zymogen granule membrane 0.471865392915783 0.0927984523846064 0.9260636805249562 1.0 1.0 3 P49755 1 +Lamin filament 0.4645088383242498 0.0857863396344991 0.931636265836158 1.0 1.0 3 P20700 1 +Granular component 0.3528455673991629 0.0852120170660259 0.932092837093784 1.0 1.0 4 Q9NXV6 1 +Spliceosomal complex 0.3053248617892173 0.0799954662878711 0.9362408617944786 1.0 1.0 122 Q9UKM9,P07910,P17844,P51991,P31943,P31942,P55081,P98179,Q96I25,Q12972,Q13123,O75400,O75533,Q13595,O43390,P55265,Q9UKA9,Q9P2K5,Q9HCS7,P09012,O43290,P19338,Q96E39,Q99459,Q9P013,P22626,P62312,Q14011,P61978,Q9BZJ0,P38159,Q8IWZ8,P67809,P52597,O75934,P09651,P62995,Q14331,Q07955 39 +Unconventional myosin complex 0.3459444019611941 0.0773146535704797 0.9383732339367225 1.0 1.0 4 O00159 1 +Endoplasmic reticulum plasma membrane contact site 0.4600326264274006 0.0754680072052089 0.9398423514757044 1.0 1.0 2 Q9NTJ5 1 +Filtration diaphragm 0.4510443864229754 0.0742575452339805 0.940805457717169 1.0 1.0 3 O00592,Q08209 2 +Endocytic vesicle lumen 0.2943482522051613 0.0587281196446417 0.953168661748734 1.0 1.0 6 Q9Y4L1,P27797,Q92598,O14964,P14625 5 +Mitotic spindle astral microtubule 0.3261508325171482 0.057930799854662 0.9538037495750364 1.0 1.0 4 Q14980,Q86Y91,Q8NI77 3 +Nuclear stress granule 0.4161968316569607 0.051563717432707 0.9588763301549326 1.0 1.0 3 P31483 1 +Site of polarized growth 0.2710216233553801 0.0495181676140252 0.9605063592972314 1.0 1.0 48 O15511,Q9Y4I1,Q8N5V2,Q99720,Q9UPT5,Q9UKA9,O60645 7 +U2af complex 0.4053524804177569 0.0463575053167205 0.9630253059202144 1.0 1.0 3 P26368,Q15637 2 +Risc loading complex 0.404699738903395 0.0460690895583797 0.9632551827985378 1.0 1.0 3 O75569,Q9UPY3 2 +Pwp2p containing subcomplex of 90s preribosome 0.2828216851730893 0.0441033533871837 0.9648220197710282 1.0 1.0 5 Q9Y5J1,Q15269,Q9NYH9,Q8NI36 4 +Neuromuscular junction 0.2491010460010828 0.0411213786016541 0.9671991313572176 1.0 1.0 16 P46939,Q96EY1,P17252,Q14168 4 +Nata complex 0.391644908616193 0.0408544300976127 0.9674119466056952 1.0 1.0 3 Q9BXJ9,P41227 2 +Smc5 smc6 complex 0.291431597560557 0.0343932059941931 0.9725636010996164 1.0 1.0 4 Q96MG7 1 +Nsl complex 0.3541122715404703 0.0308228736685623 0.9754107985351734 1.0 1.0 3 P51610,P61964 2 +Intraciliary transport particle 0.34268929503917 0.0289165070915917 0.9769311803716184 1.0 1.0 3 A0AVF1,Q7Z4L5 2 +Cell cortex region 0.2645519947678219 0.0263890423794302 0.9789470340223084 1.0 1.0 9 P35222,P61163,O60716,P09496,P56545,Q14203,Q14980,Q7Z460 8 +Dystrophin associated glycoprotein complex 0.2300913838120216 0.023255063575434 0.9814468160818126 1.0 1.0 3 P46939,Q14118 2 +Glycoprotein complex 0.2300913838120216 0.023255063575434 0.9814468160818126 1.0 1.0 3 P46939,Q14118 2 +Chromosome telomeric repeat region 0.2417974958748703 0.0159014696360384 0.9873129975512552 1.0 1.0 5 Q9NYB0 1 +Nuclear exosome rnase complex 0.2551573248776894 0.0128416270277081 0.9897541456626172 1.0 1.0 9 Q9NQT4,Q15024 2 +Dynactin complex 0.2326900126274295 0.0120468183862191 0.9903882620886476 1.0 1.0 5 Q13561,O75935 2 +Cell projection membrane 0.2528901411717618 0.0062681158825729 0.994998799860916 1.0 1.0 58 Q14728,Q9UHB6,P41440 3 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ea7f2f0a5ce80fcbcedd70264bc9d326be853fa1 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc 1 complex", "Bloc complex", "Blood microparticle", "Borc complex", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcineurin complex", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Calyx of held", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition fiber", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine head", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystroglycan complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle a", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microfibril", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class i", "Phosphatidylinositol 3 kinase complex class ia", "Phosphatidylinositol 3 kinase complex class iii", "Phospholipid translocating atpase complex", "Phosphorylase kinase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilia coupling link", "Stereocilium bundle", "Stereocilium membrane", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic cleft", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiia complex", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquinone biosynthesis complex", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPTF", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "C12orf43", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C3orf58", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARS2", "CASK", "CAST", "CBFB", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC22", "CCDC47", "CCDC51", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG4", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGA1", "GGA2", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNG12", "GNG5", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSR", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2A1", "GTF2E2", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "IST1", "ITCH", "ITGB1", "ITM2C", "IVD", "JAGN1", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NENF", "NES", "NF1", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5DC3", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANX1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGGT1B", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAMM41", "TAP2", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM41B", "TMEM43", "TMEM65", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", 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0000000000000000000000000000000000000000..f60ceb40df16519e517c53aae0fa4c11a170e814 --- /dev/null +++ b/msigdb_gomf/basic/plot_6.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5c1f1327bb70ca30812d5bd9ca3274e2efc9f648badf0cc4f56adcae18f613a1 +size 139448 diff --git a/msigdb_gomf/basic/plot_7.png b/msigdb_gomf/basic/plot_7.png new file mode 100644 index 0000000000000000000000000000000000000000..4fb3053a5db6bfbb8ff1db17b443604517bc9a5b --- /dev/null +++ b/msigdb_gomf/basic/plot_7.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3eb5be5e21ba7152564ff85a097fad685807cf8fb0d02707c7a85f23bf27508b +size 149473 diff --git a/msigdb_gomf/basic/plot_8.png b/msigdb_gomf/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..a3a7e5ec48b01db2974917faf74baf9124da6a9b --- /dev/null +++ b/msigdb_gomf/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:073e523a7281c34bf50fd80bc27a8673c45be4616316cbc4f1d54b78b637e9d1 +size 145373 diff --git a/msigdb_gomf/basic/plot_9.png b/msigdb_gomf/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..5c7c5b59c2c008ba5f84ead4bc06b75b0f08d143 --- /dev/null +++ b/msigdb_gomf/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:87e262f6a40ea8c7bdd5e552f750d0a00c85373012b8ece6b9098c7c84d6dede +size 140866 diff --git a/msigdb_gomf/consensus.joblib b/msigdb_gomf/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..11e73b52259480f40a8adba160e8459da44828bd --- /dev/null +++ b/msigdb_gomf/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:883abb1d80a59a532e9f4b8d26c8b7ce912202ee1bc1bf7f2ff80d26bd7da22d +size 143487 diff --git a/msigdb_gomf/df_merge.tsv b/msigdb_gomf/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a6c8cf9131528e77aa204a580ed2de1f74e7cad2 --- /dev/null +++ b/msigdb_gomf/df_merge.tsv @@ -0,0 +1,40 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Oxidoreductase activity acting on the ch ch group of donors 11 31 2.958222549850964 0.0030941864466551 7.567961165048544 28.033980582524272 0.602739632464327 0.3658961640745555 3.3714596992024415 2.798024733162656 1.2394975779858992 0.2994161584769358 0.0786913117941895 0.0016453439849387 7.178515274085645e-06 2.078573381251053e-07 2.672510894072328e-06 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 7 14 2.9453978482589807 0.0032253963270492 3.8398058252427183 12.78883495145631 0.8288316105774708 0.2715528044153261 1.786836430207192 1.277729935586139 1.1940635938633195 0.228034100916913 1.0 0.0053672672920639 6.426860752013887e-05 7.91629771918297e-07 7.490488694519441e-06 +Organic acid transmembrane transporter activity 7 22 2.666540399414305 0.0076636394994218 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 0.1076057072869973 0.0421554091664212 0.000500939423253 0.0012385676091947 0.005344696455789 +Collagen binding 2 8 2.6507313287110668 0.0080317704282246 2.716019417475728 8.723300970873787 0.69823887636622 0.4150184287426759 1.4191600413356955 1.3333441338677146 0.9396547940704922 0.2968068810392446 0.00118263978695 0.0004265388560116 0.0032769664110839 0.0383377547470353 0.1889957663081205 +Tetrapyrrole binding 8 16 2.580953658032588 0.0098527806936983 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 1.0 0.2295798469686227 0.0154029461510805 0.0413751204339429 0.001050513287845 +Protein kinase activity 17 76 2.4776085811147275 0.0132266157048128 24.711165048543688 85.15776699029126 -0.2630746242467029 0.6428628304343708 10.70326016942092 16.186469924165078 0.7783417694745319 0.3043865168638158 0.0281271623664141 0.0443764733906126 0.0434306338767803 0.2802939730530193 0.6902717802070295 +Protein serine threonine kinase activity 14 61 2.471727805726458 0.0134461851580389 21.385922330097088 69.94902912621359 -0.2265230805291581 0.6116443932751089 9.55815596799563 14.238769174373656 0.8662596685370179 0.315939433499304 0.0151464026889756 0.0184206575863174 0.036397617375934 0.2517678011925938 0.5991478676694187 +Histone kinase activity 2 8 2.470141485582286 0.013505962243981 3.529126213592233 8.257281553398059 -0.2312260534263842 0.5802246367653978 2.063700656962113 2.1591576001040096 0.7602924856934962 0.2833303905664626 0.0002712699501443 0.0022827689145391 0.0003712110430798 0.0051503840765812 0.0048822579474643 +Cyclin dependent protein kinase activity 3 6 2.462981295679952 0.0137787103669673 3.0776699029126213 7.009708737864078 0.1750743715485782 0.5591716847129228 1.831171943634026 1.6604780317147063 0.8949013618996786 0.3078493244498897 0.0007674939561263 0.0002227197090729 0.0017488676437986 0.0028478177309091 0.0308662830144804 +Cyclin binding 2 13 2.432632393261996 0.0149895104653734 3.79126213592233 12.1626213592233 -0.0800712500327452 0.6257445612435953 2.2694940540529833 1.6517895333414625 0.7361106592549189 0.2826150802974327 0.0008306370916782 0.000250920769273 0.0019631407021181 0.0242110622206542 0.0351238878380088 +Fad binding 4 11 2.3998876047159383 0.0164001066073986 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.0425098423004131 0.0068317681715133 0.0019631407021181 0.0033024410276518 0.0074494564855197 +Metalloendopeptidase activity 5 14 2.384253359902635 0.017113815459707 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 1.0 1.0 0.0405463165390607 0.007920049564759 0.0045924061823516 +Protein serine threonine tyrosine kinase activity 13 56 2.366031892822242 0.0179798954695225 19.475728155339805 63.939320388349515 -0.3064367199223224 0.6001763214586637 8.904122161116224 13.055843743274796 0.8725878237254184 0.322654526690802 0.0151464026889756 0.0184206575863174 0.036397617375934 0.5185093311023266 0.699613558143403 +Organic anion transmembrane transporter activity 7 32 2.3567757919157417 0.0184343732845739 12.951456310679612 30.182038834951456 1.56101282472555 0.2452312368187786 6.880574373146614 3.5222410835885483 1.575669523214114 0.314839840161206 1.0 0.3371313972628795 0.0001694771292921 0.0010205325993841 0.0078989663196461 +Rna polymerase ii ctd heptapeptide repeat kinase activity 1 6 2.3090498630187923 0.0209408144460043 2.8398058252427183 6.405339805825243 0.1033195102598503 0.5936297583704048 1.6789872008292948 1.4542440838476145 0.8524061720677978 0.3041510988580383 0.0198359893050149 0.0014481500629001 0.0057815105752346 0.0328731354880699 0.1125747569923622 +Organic cation transmembrane transporter activity 2 5 2.3057659821766485 0.0211237119878129 1.9271844660194175 5.04126213592233 1.6158747778246996 0.14183106997637 1.275055237696066 0.9168044752551467 0.8418646651592007 0.1871331589544055 1.0 0.0652597674910206 0.0078714328443906 0.0041946485896371 0.0277461310389573 +Macromolecule transmembrane transporter activity 5 12 2.2529616174286744 0.0242615691692056 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.0004884682976576 0.0040679264544396 0.0008978593047678 0.0011993766429203 0.0002747300414667 +Copper ion binding 0 9 2.2387056841639943 0.0251750724472603 2.4805825242718447 9.395631067961164 0.298010576811855 0.4301582785794527 1.6552686258647775 1.5426872090784312 1.0475904656710089 0.2911939339780537 0.0552437329748951 0.151306852499084 0.2827159209662828 0.5661975770404395 0.4967295098899271 +Protein transmembrane transporter activity 3 11 2.208496291468729 0.02720969604624 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 0.0003506706272306 0.0029386578360865 0.0005470061355849 0.00062382482254 0.0010053263520343 +Modified amino acid binding 3 23 2.19808817247941 0.0279428232080232 4.446601941747573 21.354368932038835 0.8157790161756342 0.4133026066112408 2.099367243274066 1.7995833767593454 0.9656025978141096 0.3166170247143811 1.0 0.0221752921752284 0.0111977735740575 0.0284489140367958 0.2029818831286367 +Protein serine kinase activity 7 51 2.1971227106153903 0.0280116835593629 18.606796116504853 58.79368932038835 -0.2547746046050501 0.5863977102077378 8.497901078786414 12.25769657088421 0.9472615480729644 0.3269248883217332 0.009774211427029 0.0096723767157603 0.0167979704368877 0.3423470252365037 0.5696776559181163 +1 phosphatidylinositol binding 1 6 2.183831462563277 0.0289746347514334 0.9296116504854368 5.730582524271845 0.5854159685461776 0.452723274314548 1.2912689794694188 0.5192756815806097 0.8614060502856912 0.2874504674264635 1.0 0.0652597674910206 0.1277572387780678 0.0439142352380576 0.1457988469723397 +Atpase coupled transmembrane transporter activity 6 21 2.1667488502545464 0.0302540095397965 8.072815533980583 22.696601941747577 0.8561067713091313 0.3392846662603397 4.166386392056555 3.892074110340729 1.3163009809214623 0.3229730128136945 0.0924957985250946 0.2443632781182481 0.4330643878145832 0.1655021226103433 0.0215069931551279 +Abc type transporter activity 3 7 2.161139027397315 0.0306846016288362 3.0194174757281553 7.652912621359223 0.9831250219385844 0.2361571806590424 1.9482657586917436 2.350049836723345 1.2743804993059251 0.258194993176919 0.0409067959471478 0.1135912525516411 0.2166826538338764 0.0217985290060267 0.0308662830144804 +Protein kinase a catalytic subunit binding 1 6 2.1259141911919985 0.0335104050398351 2.633495145631068 5.614077669902913 0.1046084497159543 0.6045101053814899 1.6921131780285823 0.8998898928258415 0.8011653161657268 0.3001240998588403 0.0181972414507802 0.0012105019492812 0.0048484802924912 0.027832231049335 0.0968157430558884 +Amyloid beta binding 1 11 2.104042792415932 0.0353747143668965 3.5898058252427183 10.560679611650484 1.053866189591651 0.2544642672774957 2.009490338022764 1.9342863324228672 1.0942484681219342 0.2534200432416059 1.0 0.1635258499471353 0.0498890213657128 0.2256009180273313 0.5423832826720252 +Acylglycerol o acyltransferase activity 2 7 2.102787259823255 0.0354843701948979 2.6601941747572817 6.820388349514563 0.8174935736497821 0.2734948556707107 1.708365471336677 1.514259678343348 1.2372108727630755 0.2654117957889352 1.0 0.0963063052639835 0.1854358412925483 0.090818300458346 0.0790607116166092 +Cholesterol binding 6 13 2.092201663054878 0.0364204798027316 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 1.0 1.0 0.2540772386550496 0.0352396407582777 0.0004675519327548 +Lipopolysaccharide binding 1 6 2.0853753421638297 0.0370352432844103 1.3325242718446602 6.762135922330097 0.8069967393930578 0.3801019166455804 1.1293139239074608 0.4639669608371066 0.8740381370360097 0.2828250429158399 1.0 0.0006219606051344 0.0025156479029566 0.0148625463558957 0.0542215392640632 +Flavin adenine dinucleotide binding 5 30 2.079778671989075 0.0375458382248405 7.37621359223301 27.813106796116504 0.6719710250262334 0.465219074258643 3.908755076189923 2.8788689557398657 1.0329905694282788 0.3336749641062707 0.0985684288988407 0.0356328568827733 0.0030320155718172 0.0168986737095617 0.0792626216408109 +Threonine type endopeptidase activity 3 8 2.066151562988761 0.0388141707774281 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 0.0470522829573702 0.0001014210629885 6.292953854873037e-05 0.0009118158302113 +Protein disulfide isomerase activity 7 9 2.06247124042758 0.0391628928970384 4.434466019417476 9.563106796116504 -0.1224461253084721 0.5520306684175431 2.5261883594629473 1.1270711499031922 0.971679429818008 0.3237411433088434 1.0 1.0 1.0 0.3411306657380243 0.0010053263520343 +Protein transporter activity 5 14 2.060649204097962 0.0393365189453673 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 0.0007674939561263 0.0063255491406275 0.0017488676437986 0.0028478177309091 0.0010205277760807 +Nf kappab binding 2 12 2.060086829858511 0.0393902407004576 4.140776699029126 14.49271844660194 -0.0982418672330339 0.6815400635455378 2.532236315188991 1.8081383947884813 0.6262582299224563 0.2536914818686193 1.0 0.134742527043449 0.2540772386550496 0.1637924032376012 0.1766336232289773 +Peptide binding 12 72 2.043148686887595 0.041037721536401 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 1.0 0.1570363283812061 0.0030251437486506 0.0662814957949843 0.026405343511034 +Endopeptidase activity 15 55 2.02508045528634 0.0428591034709961 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 1.0 0.1896040470106967 0.0054813378254122 0.0023395565243993 0.0028710917511246 +Serine hydrolase activity 6 17 2.0148543737730047 0.0439199098549694 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 1.0 0.0221752921752284 0.0789500483472863 0.005869339632186 0.0079620077053278 +Tau protein binding 1 14 1.9882511359009691 0.046783922057014 6.109223300970874 16.856796116504853 -0.2107866501387664 0.5688162745436043 3.9357969275600393 2.5325794493301457 0.8302528024929796 0.2889230627221487 0.0646893669285592 0.0157111699130222 0.0573531962335191 0.2526409373615763 0.307100773996071 +Iron ion binding 7 20 1.9758079635975048 0.0481765311522275 6.524271844660194 22.196601941747577 0.9076096695164306 0.382669917893863 2.4429198675966717 3.289094676807881 0.9378690899634522 0.3126784916965753 1.0 0.0345877004093447 0.0028574061260132 0.0034676048515423 0.008913025090531 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0079ea5202c0778f49707199c7823dd351b1b51f --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 1376, + "title": "Average number of proteins per term", + "value": 16.178052325581394 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8a4acbca70d46faa453d808cbbc4d8711b74e190 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..13a7b1e07545771e032a1befe456f08fa8459027 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,340 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Oxidoreductase activity acting on the ch ch group of donors 0.6902998939702654 2.9582225498509636 0.0030941864466551 0.9859369019873084 0.2369573680655215 31 P50336,P36551,Q9BY49,Q15067,Q15392,Q14914,Q8N8N7,Q8N4Q0,Q14739,O15254,Q9H7Z7 11 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.8125426698588442 2.9453978482589807 0.0032253963270492 0.9882666276817308 0.2369573680655215 14 Q9BY49,Q15392,Q8N8N7,Q14739,Q8N4Q0,Q14914,Q9H7Z7 7 +Organic acid transmembrane transporter activity 0.6807618397713728 2.666540399414305 0.0076636394994218 0.9999747272235696 0.2369573680655215 22 Q9Y619,Q9BQT8,P08183,O15439,P30825,P41440,P53985 7 +Collagen binding 0.908712948844234 2.6507313287110668 0.0080317704282246 0.9999848322276274 0.2369573680655215 8 Q92791,O75718 2 +Tetrapyrrole binding 0.7251187263817752 2.5809536580325876 0.0098527806936983 0.9999987897182592 0.2369573680655215 16 Q8WUJ1,Q6UW02,Q16850,P30519,O15173,P09601,O43169,Q9H7Z7 8 +Protein kinase activity 0.4819110189849722 2.4776085811147275 0.0132266157048128 0.9999999889546488 0.2369573680655215 76 Q96GD4,P07948,Q12792,O14874,Q14004,O14936,P49840,Q13464,P49841,P25440,P17252,O14976,Q8NI60,P53350,P06493,P24941,P21127 17 +Protein serine threonine kinase activity 0.50046182923481 2.471727805726458 0.0134461851580389 0.9999999918680698 0.2369573680655215 61 Q96GD4,O14874,Q14004,O14936,P49840,Q13464,P49841,P25440,P17252,O14976,P53350,P06493,P24941,P21127 14 +Histone kinase activity 0.8652580358604973 2.470141485582286 0.013505962243981 0.9999999925185888 0.2369573680655215 8 P06493,P24941 2 +Cyclin dependent protein kinase activity 0.922606363676838 2.462981295679952 0.0137787103669673 0.9999999948862692 0.2369573680655215 6 P06493,P24941,Q14004 3 +Cyclin binding 0.7385419614504884 2.432632393261996 0.0149895104653734 0.9999999990567712 0.2369573680655215 13 P06493,P24941 2 +Fad binding 0.7817034344498922 2.3998876047159383 0.0164001066073986 0.999999999868714 0.2400696456572399 11 Q15067,Q15392,O95831,O15254 4 +Metalloendopeptidase activity 0.7029570931949048 2.384253359902635 0.017113815459707 0.9999999999516446 0.245298021589134 14 Q5JRX3,Q10713,P22695,O75844,P42892 5 +Protein serine threonine tyrosine kinase activity 0.5170585461294309 2.366031892822242 0.0179798954695225 0.9999999999856238 0.251087832245548 56 Q96GD4,P07948,Q14004,O14936,P49840,Q13464,P49841,P17252,O14976,P53350,P06493,P24941,P21127 13 +Organic anion transmembrane transporter activity 0.5991891129324889 2.3567757919157417 0.0184343732845739 0.9999999999923964 0.2527901737581091 32 Q14728,Q9BQT8,O15439,Q99808,P30825,P41440,P53985 7 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.8839151364996976 2.3090498630187923 0.0209408144460043 0.9999999999997744 0.27092220239306 6 P06493 1 +Organic cation transmembrane transporter activity 0.9241493332222694 2.3057659821766485 0.0211237119878129 0.9999999999998256 0.27092220239306 5 Q99808,O43772 2 +Macromolecule transmembrane transporter activity 0.7273359107481476 2.2529616174286744 0.0242615691692056 0.999999999999998 0.28694709990173 12 Q9NS69,Q9Y584,Q99595,O60830,P49755 5 +Protein transmembrane transporter activity 0.7412099095986718 2.208496291468729 0.02720969604624 1.0 0.3120045146635521 11 Q9NS69,Q99595,O60830 3 +Modified amino acid binding 0.5954070399797676 2.19808817247941 0.0279428232080232 1.0 0.313366476241328 23 Q8WTV0,Q9H7Z7,P41440 3 +Protein serine kinase activity 0.5213687808248489 2.1971227106153903 0.0280116835593629 1.0 0.313366476241328 51 Q96GD4,Q14004,P49840,P49841,P53350,P06493,P24941 7 +1 phosphatidylinositol binding 0.8529430007961061 2.183831462563277 0.0289746347514334 1.0 0.3215249791771972 6 Q8WTV0 1 +Atpase coupled transmembrane transporter activity 0.6099022285368392 2.1667488502545464 0.0302540095397965 1.0 0.3252306025528125 21 P06576,P08183,Q9Y5K8,O15439,P28288,P36543 6 +Abc type transporter activity 0.8079973774220933 2.161139027397315 0.0306846016288362 1.0 0.3273024173742532 7 P08183,P28288,O15439 3 +Protein kinase a catalytic subunit binding 0.8387631312050812 2.1259141911919985 0.0335104050398351 1.0 0.3466941152993472 6 P49840 1 +Amyloid beta binding 0.7194761240054945 2.104042792415932 0.0353747143668965 1.0 0.3507495028839493 11 Q8WTV0 1 +Acylglycerol o acyltransferase activity 0.794361547737211 2.102787259823255 0.0354843701948979 1.0 0.3507495028839493 7 Q8NCC3,Q96N66 2 +Cholesterol binding 0.6722941623958176 2.092201663054878 0.0364204798027316 1.0 0.3519543584664263 13 P35610,P21796,O15118,P08133,P30536,Q9H4L5 6 +Lipopolysaccharide binding 0.8288909771179035 2.0853753421638297 0.0370352432844103 1.0 0.3519543584664263 6 Q8WTV0 1 +Flavin adenine dinucleotide binding 0.562804345557286 2.079778671989075 0.0375458382248405 1.0 0.3519543584664263 30 P50336,Q15067,Q15392,O95831,O15254 5 +Threonine type endopeptidase activity 0.7713633341825642 2.0661515629887615 0.0388141707774281 1.0 0.3519543584664263 8 Q99436,P28070,P49721 3 +Protein disulfide isomerase activity 0.7559253781305494 2.0624712404275796 0.0391628928970384 1.0 0.3519543584664263 9 P30101,Q96JJ7,Q8NBS9,P13667,P07237,Q15084,Q6ZRP7 7 +Protein transporter activity 0.6428929134088505 2.060649204097962 0.0393365189453673 1.0 0.3519543584664263 14 Q9NS69,Q9Y584,Q99595,O60830,P49755 5 +Nf kappab binding 0.6887089962704389 2.060086829858511 0.0393902407004576 1.0 0.3519543584664263 12 P09525,P49841 2 +Peptide binding 0.4365415246114918 2.043148686887595 0.041037721536401 1.0 0.355144055560301 72 Q92973,P55786,Q9Y584,P42892,O14773,P04439,Q15392,Q6P179,Q9NQX7,Q14978,Q8WTV0,Q9H7Z7 12 +Endopeptidase activity 0.4847413895052197 2.02508045528634 0.0428591034709961 1.0 0.3685882898505673 55 Q5JRX3,Q9Y4W6,Q96RU2,P28074,Q4J6C6,Q10713,O14773,P22695,P28070,Q16740,O75844,Q96K76,P42892,P49721,Q99436 15 +Serine hydrolase activity 0.6164741489778618 2.0148543737730047 0.0439199098549694 1.0 0.3707594844198644 17 Q5JRX3,Q9HB40,Q4J6C6,P42785,Q16740,Q9H3G5 6 +Tau protein binding 0.6297337941154955 1.9882511359009696 0.046783922057014 1.0 0.3860943738469307 14 P49840 1 +Iron ion binding 0.5878604485898137 1.9758079635975048 0.0481765311522275 1.0 0.3922538867778999 20 P22830,Q9BU89,Q32P28,Q6UW02,Q16850,O15460,P13674 7 +Procollagen proline dioxygenase activity 0.9151158994449886 1.9578447420820473 0.0502482335405187 1.0 0.3996622505881724 4 O15460,Q32P28,P13674 3 +Peptidyl proline dioxygenase activity 0.9151158994449886 1.9578447420820473 0.0502482335405187 1.0 0.3996622505881724 4 O15460,Q32P28,P13674 3 +O acyltransferase activity 0.6673531609953117 1.9517365279275616 0.0509694934426541 1.0 0.4012170765074977 12 P35610,P23786,Q8NCC3,Q96N66 4 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.5432014548620091 1.933281523555256 0.0532015266426642 1.0 0.4025904942085846 29 P07237,Q9BU89,Q32P28,Q6UW02,Q16850,O95864,P30519,O15460,P13674,Q8NB78 10 +Dicarboxylic acid transmembrane transporter activity 0.7508953088817218 1.9142855587323808 0.0555836786356329 1.0 0.4036004665026012 7 P41440 1 +Xenobiotic transmembrane transporter activity 0.8957688053147179 1.8843992817015704 0.0595109869342733 1.0 0.4137740476270962 4 P08183,P41440 2 +Calcium dependent phospholipid binding 0.6936099855853427 1.8727798420483597 0.0610987926835857 1.0 0.4137740476270962 10 P20073,P09525,P50995 3 +Nucleobase containing compound transmembrane transporter activity 0.5996306230403067 1.82070109747134 0.0686523052759211 1.0 0.4496557706230868 14 Q99808,P51991,O15439,P41440 4 +Prenyltransferase activity 0.7214146028356982 1.7843515858065857 0.0743665527839834 1.0 0.4713586581883013 7 P49354 1 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 0.7895579009616338 1.7717534305185567 0.0764354960506901 1.0 0.4802522491586739 5 P50336,Q15067,O15254 3 +Purine nucleotide transmembrane transporter activity 0.6477791678688882 1.7512125673790937 0.0799093014938199 1.0 0.4897984260243853 11 Q99808,P41440 2 +Serine type exopeptidase activity 0.7135410825319971 1.749379879682003 0.080225376439833 1.0 0.4897984260243853 7 P42785,Q9H3G5,Q9HB40 3 +Nucleotide transmembrane transporter activity 0.6262488097281014 1.7399353168873917 0.0818703764430295 1.0 0.4897984260243853 12 Q99808,P41440 2 +Organophosphate ester transmembrane transporter activity 0.6262488097281014 1.7399353168873917 0.0818703764430295 1.0 0.4897984260243853 12 Q99808,P41440 2 +Serine type carboxypeptidase activity 0.779575324398448 1.7310573161595613 0.0834415422733114 1.0 0.493610355695946 5 P42785,Q9HB40 2 +Cation transmembrane transporter activity 0.4100142761750286 1.7226945029729133 0.0849437849296348 1.0 0.4973729704816065 74 Q9HD20,O43772,P00846,Q13423,P06576,P30825,P36543,Q9Y619,Q9UM00,Q8TAD4,Q99808,Q6P4Q7,Q70HW3,Q9Y5K8,Q93050,P08574,P00403,P08133,Q15758 19 +Monooxygenase activity 0.6809325856945655 1.7189396006618418 0.0856253704180116 1.0 0.4992394478609493 9 Q9BU89,Q6UW02,Q16850,P30519,P09601 5 +Sterol binding 0.5701342727857985 1.7087423872418253 0.0874986787949996 1.0 0.5060853496804147 16 P35610,P21796,O15118,P08133,P30536,Q9H4L5 6 +Threonine type peptidase activity 0.6769172987336061 1.7002280206911409 0.0890880435580232 1.0 0.5070116227748529 9 Q99436,P28070,P49721 3 +Protein kinase a binding 0.5631443980099179 1.6997965788075344 0.0891691952845308 1.0 0.5070116227748529 17 P49840,P49841,P17252,O43823,Q92667 5 +Carbohydrate derivative transmembrane transporter activity 0.635336639956025 1.688778641507917 0.0912618583824398 1.0 0.5125563964662743 11 P41440 1 +Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor 0.5405303972940734 1.6774266834463332 0.0934590751369501 1.0 0.52064650764552 20 O94788 1 +Oxidoreductase activity acting on the aldehyde or oxo group of donors 0.5312673219584945 1.6638940819894477 0.0961335978887429 1.0 0.5295126790793248 21 O94788 1 +Aldehyde dehydrogenase nad p plus activity 0.6928056865593999 1.6567677217102572 0.0975664452655107 1.0 0.5295126790793248 7 O94788 1 +Tau protein kinase activity 0.8358677741323259 1.6542830182467605 0.0980700217320684 1.0 0.5295126790793248 4 P49840 1 +Anion transmembrane transporter activity 0.4660884087607189 1.6500177017613704 0.0989393155815876 1.0 0.5295126790793248 49 Q14728,Q9BQT8,Q8TDW0,O15439,Q99808,Q6N075,P30825,P41440,P53985 9 +L amino acid transmembrane transporter activity 0.6784365582933565 1.6483365553363387 0.0992836273273733 1.0 0.5295126790793248 8 Q9H9B4,Q15758,P30825,Q9Y619 4 +Hydrolase activity hydrolyzing n glycosyl compounds 0.6834180383237208 1.614607405301789 0.1063957407569913 1.0 0.5372121802294192 7 Q16706,P29372,P78549 3 +Sphingosine n acyltransferase activity 0.9729200652528543 1.6091357978034748 0.1075866511605221 1.0 0.5372121802294192 2 Q96G23 1 +Atp dependent peptidase activity 0.7486078970865054 1.6040089154898132 0.1087120874222518 1.0 0.5372121802294192 5 Q16740 1 +C acetyltransferase activity 0.6799716916247815 1.5990954973474325 0.10979938501556 1.0 0.5376653159480806 7 Q9BWD1,P35610 2 +Lysophosphatidic acid phosphatase activity 0.9683523654159852 1.5910387942168576 0.1116008453917718 1.0 0.5396576746505596 2 Q9NPH0 1 +Alpha tubulin binding 0.7074759907501329 1.573279872727125 0.1156540277135385 1.0 0.5467711796511627 6 P49354 1 +Dna n glycosylase activity 0.733505229150754 1.5416527120341164 0.1231580088987387 1.0 0.5587981056227974 5 P78549 1 +Endoribonuclease activity producing 5 phosphomonoesters 0.5682934501031995 1.5332866248918997 0.1252052486501145 1.0 0.5587981056227974 13 O15091,Q9UQ84 2 +Amino acid transmembrane transporter activity 0.6216812164677945 1.5250145291756334 0.1272554737833768 1.0 0.5636600373831688 10 Q9Y619,Q15758,P30825,Q9H9B4,Q96NB2 5 +Phosphatidylinositol 3 4 5 trisphosphate binding 0.6342209632608629 1.4995428634870704 0.1337328575856369 1.0 0.57325985058516 9 Q9H0H5 1 +Abc type xenobiotic transporter activity 0.9435562805872716 1.4927425399971663 0.1355045933515239 1.0 0.575446466852594 2 P08183 1 +Efflux transmembrane transporter activity 0.9435562805872716 1.4927425399971663 0.1355045933515239 1.0 0.575446466852594 2 P08183 1 +Magnesium ion binding 0.388146340771962 1.4741919894071722 0.1404299060761582 1.0 0.583540307725918 64 P34913,Q9Y3B8,P30520,P48735,Q969T7,P53350,P24941 7 +Lysophospholipid acyltransferase activity 0.6826022024011975 1.465750212822632 0.1427163491275727 1.0 0.5875415260585607 6 Q96N66 1 +Epoxide hydrolase activity 0.7146600402323979 1.463539990146911 0.1433196794176336 1.0 0.5875415260585607 5 P07099 1 +Ether hydrolase activity 0.7146600402323979 1.463539990146911 0.1433196794176336 1.0 0.5875415260585607 5 P07099 1 +L ornithine transmembrane transporter activity 0.9360522022838462 1.4629924589987782 0.1434694424096485 1.0 0.5875415260585607 2 P30825 1 +Pentosyltransferase activity 0.5285642449822999 1.4376413684047218 0.150535836844617 1.0 0.5966629276500109 15 Q13126 1 +Amide transmembrane transporter activity 0.7060541431583952 1.4277737471924443 0.1533569915112393 1.0 0.5979364001312333 5 P41440 1 +Chromo shadow domain binding 0.7751974988330346 1.4179511191549008 0.1562050363055336 1.0 0.6027940598016569 4 P46100 1 +Organic hydroxy compound transmembrane transporter activity 0.943864229765016 1.4143141943249553 0.1572696711255776 1.0 0.6027940598016569 3 P53985,Q14728 2 +Exodeoxyribonuclease activity 0.5972594819597636 1.404925113553129 0.160043547853347 1.0 0.6072627269042652 10 Q9UQ84 1 +Hydrolase activity acting on ether bonds 0.6358512640409804 1.39909193354772 0.1617854163286276 1.0 0.6109738788136312 7 P07099 1 +Monocarboxylic acid transmembrane transporter activity 0.6670372414049508 1.3981503401047042 0.1620679257027437 1.0 0.6109738788136312 6 P53985,O15439 2 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.5208645103979876 1.3924642552534714 0.1637818585345258 1.0 0.6148499053246557 15 O15091,Q9UQ84 2 +Peptide antigen binding 0.6652507328265574 1.3903787608117115 0.1644138925147817 1.0 0.6148499053246557 6 P04439,Q15392 2 +Arylesterase activity 0.9138662316476288 1.3751004746602669 0.1691002972449071 1.0 0.6210961013638293 2 Q15165 1 +Lipid transporter activity 0.4797693969028437 1.367751001134374 0.1713900298260473 1.0 0.6210961013638293 22 O15118,P08183,O15439,P28288,P30536,Q9H4L5 6 +Exogenous protein binding 0.5161856462435801 1.3649731368994438 0.172261493276032 1.0 0.6210961013638293 15 P06493 1 +Nucleosomal dna binding 0.4720104416225874 1.362375061574732 0.1730795498984854 1.0 0.6210961013638293 23 P10412,O95983,P84243,P07910,P07305,Q8TAQ2,P16402,Q8WXI9,P16403,Q969G3 10 +Phosphatidylinositol 3 kinase regulator activity 0.9102773246329492 1.3608986086456725 0.1735457332943952 1.0 0.6210961013638293 2 O00459 1 +5 3 exonuclease activity 0.6038602552609849 1.3552588849757412 0.1753350895022234 1.0 0.6224998450866154 9 Q9UQ84 1 +3 5 exodeoxyribonuclease activity 0.6568787685180789 1.3539300754189756 0.1757586872751375 1.0 0.6224998450866154 6 Q9Y3B8 1 +Signaling receptor regulator activity 0.5094623672727706 1.3484897043195796 0.1775009293940594 1.0 0.623064486852617 16 Q9UMX5,P14174 2 +Ion transmembrane transporter activity 0.4106874452410754 1.340186002806232 0.1801848810718078 1.0 0.6245198900624876 105 Q9HD20,O43772,P41440,P00846,Q13423,P06576,Q8TDW0,O15439,Q6N075,P30825,P36543,Q14728,Q9Y619,Q9BQT8,P21796,Q9UM00,Q8TAD4,Q99808,Q8IWT6,P53985,Q6P4Q7,Q70HW3,Q9Y5K8,Q93050,P08574,P08133,P00403,Q15758 28 +C acyltransferase activity 0.5649399825561117 1.33032673365097 0.1834106426721633 1.0 0.6309326107922418 11 Q9BWD1,P35610 2 +Neutral amino acid transmembrane transporter activity 0.6808850836306157 1.3229201815848188 0.1858619230910223 1.0 0.6330346687456602 5 Q9H9B4,Q15758,Q96NB2 3 +Steroid binding 0.4725480222224694 1.3186649068684122 0.187281163861219 1.0 0.633331210026043 22 P35610,P21796,O15118,P08133,P30536,Q9H4L5,O15173 7 +Dynactin binding 0.6482687226578895 1.316401553674878 0.1880393012376355 1.0 0.633331210026043 6 P49841 1 +Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor 0.8975530179445328 1.310601747049276 0.18999234868797 1.0 0.63371299562809 2 Q8IXB1 1 +Procollagen proline 4 dioxygenase activity 0.9148172323759788 1.309969930418465 0.1902060081354659 1.0 0.63371299562809 3 O15460,P13674 2 +Peptidyl proline 4 dioxygenase activity 0.9148172323759788 1.309969930418465 0.1902060081354659 1.0 0.63371299562809 3 O15460,P13674 2 +Dna apurinic or apyrimidinic site endonuclease activity 0.746099096472644 1.3039746282585205 0.1922422331849218 1.0 0.6350516394856682 4 P78549 1 +Transporter activity 0.4720391719293331 1.2997241139163584 0.1936955425479067 1.0 0.6350516394856682 176 Q6NT16,Q99595,Q9H2V7,P08183,O43772,Q8IXU6,P41440,Q9H4L5,Q8WTV0,O60830,O15173,P00846,P06576,Q13428,O15118,Q8TDW0,O15439,Q6N075,O14975,P30825,P49755,P36543,Q9NS69,Q14728,Q9Y619,Q9BQT8,P21796,Q8TAD4,Q99808,P30536,P28288,P53985,P39210,Q9Y584,P03915,Q6P4Q7,Q70HW3,Q9Y5K8,P08133,O43676 40 +L ascorbic acid binding 0.6443005651635574 1.2990937178432898 0.1939117687740106 1.0 0.6350516394856682 6 O15460,Q32P28 2 +Hormone binding 0.6014869085916816 1.2915983476397026 0.1964962765794258 1.0 0.6377347941896669 8 P42892 1 +Modified amino acid transmembrane transporter activity 0.9096849898181254 1.2915549815735048 0.1965113028607694 1.0 0.6377347941896669 3 P41440 1 +Pseudouridine synthase activity 0.6717710244450456 1.2848911097177411 0.1988303380566618 1.0 0.6437005929846812 5 Q96PZ0,Q6P087 2 +Palmitoyl protein hydrolase activity 0.6397549703452974 1.2792600570479855 0.200805493294778 1.0 0.6437005929846812 6 Q9NUJ1 1 +Endoribonuclease activity 0.4888534552327651 1.276937856093834 0.2016241878127855 1.0 0.6437005929846812 18 O15091,Q9UQ84 2 +G quadruplex dna binding 0.667819439255945 1.2683981568252636 0.2046557995231328 1.0 0.6437005929846812 5 Q9H2U1,P36776,Q92878 3 +Phosphatidylserine binding 0.5695465470390895 1.2678634858064537 0.2048467057606109 1.0 0.6437005929846812 10 Q8WTV0 1 +Oxidoreductase activity acting on a sulfur group of donors 0.4515866924480473 1.2668324188793936 0.205215217531808 1.0 0.6437005929846812 25 P30101,Q96JJ7,P07237,Q6ZRP7,Q15084,Q9H3N1,O43396,Q8IXB1,O95881,Q9UHG3,P13667 11 +Acetyl coa c acetyltransferase activity 0.6362355585900314 1.263899681430684 0.2062660361660346 1.0 0.6437005929846812 6 P35610 1 +Atpase coupled cation transmembrane transporter activity 0.4943005176775106 1.217870177968609 0.2232733105306796 1.0 0.6658296582145947 14 Q9Y5K8,P36543,P06576 3 +N6 methyladenosine containing rna binding 0.7191774232217383 1.198518112811232 0.2307153759068643 1.0 0.6716613345423607 4 P22626 1 +Pyrophosphate hydrolysis driven proton transmembrane transporter activity 0.5815019936203218 1.1980858838032848 0.2308835837489364 1.0 0.6716613345423607 8 P36543,P06576 2 +Atpase coupled ion transmembrane transporter activity 0.5815019936203218 1.1980858838032848 0.2308835837489364 1.0 0.6716613345423607 8 P36543,P06576 2 +Demethylase activity 0.5548430887401163 1.1949602489726383 0.2321025613887051 1.0 0.6737829630186882 10 Q16850,Q8NB78 2 +Peptidase activity 0.3984611342448013 1.19212698636333 0.2332114569374075 1.0 0.6741574889619175 106 Q5JRX3,P36551,P28074,P42785,P55786,Q9Y4W6,Q4J6C6,O14773,P28070,O75844,Q96K76,P42892,P49721,Q99436,P22695,Q7Z2K6,Q96RU2,Q9HB40,Q10713,Q16740,Q9H3G5 21 +Alcohol binding 0.4825986971448311 1.1873366676087935 0.2350948502239755 1.0 0.6767583972974694 16 P35610,P21796,O15118,P08133,P30536,Q9H4L5 6 +2 oxoglutarate dependent dioxygenase activity 0.4851915019826732 1.1824366894614784 0.2370324724726895 1.0 0.6809116537002522 15 O15460,Q32P28,P13674,P07237 4 +Metallopeptidase activity 0.4306994808570028 1.1757743106296832 0.2396850745701362 1.0 0.6825539184779815 40 Q5JRX3,P55786,Q9Y4W6,P36551,Q10713,P22695,Q7Z2K6,P09960,O75844,P42892 10 +Transition metal ion transmembrane transporter activity 0.7131436798298472 1.174914472528859 0.2400289348997519 1.0 0.6825539184779815 4 Q8TAD4,Q9HD20 2 +Acetyl coa c acyltransferase activity 0.5761387010675277 1.172976581109029 0.240805197154718 1.0 0.6825539184779815 8 P35610 1 +Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor 0.7119050117702017 1.1700712232974315 0.2419723078522524 1.0 0.6836835638700192 4 Q9UHG3 1 +Fatty acid binding 0.5744320688291593 1.1649868794404323 0.2440243038599738 1.0 0.6852600859414776 8 O15254 1 +R smad binding 0.7075535736385742 1.1530641449215258 0.248884057052781 1.0 0.6890633048382832 4 Q9H6Z4,P09874 2 +Sterol transporter activity 0.5773312300129867 1.1313135351228092 0.2579231494596898 1.0 0.7008259670530045 7 Q9H4L5,P30536 2 +Minor groove of adenine thymine rich dna binding 0.700190411379775 1.1243155373989129 0.2608791892294053 1.0 0.7063910231251537 4 P07305 1 +Actin monomer binding 0.6322628932627975 1.1200836598736927 0.2626781130798541 1.0 0.7063910231251537 5 Q12792,Q9UHB6 2 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.8456769983686712 1.107093228698164 0.2682536228221956 1.0 0.7063910231251537 2 P30519 1 +Hsp70 protein binding 0.472386672831918 1.1070189974791866 0.2682857148239086 1.0 0.7063910231251537 15 Q96EY1,O60884,Q99543,P06493,Q8IXB1 5 +Guanylate kinase activity 0.6928541474358835 1.0957159259105096 0.2732031109484638 1.0 0.7106379596693502 4 O14936,Q14168 2 +Oxidoreductase activity acting on other nitrogenous compounds as donors 0.623043655764989 1.0817276409016727 0.27937356725941 1.0 0.7225902792273461 5 O43169,Q5VT66 2 +Acyltransferase activity 0.3937316004186679 1.0756811627200693 0.2820698748746097 1.0 0.7241196787825802 52 Q96G23,P35610,Q96N66,Q8NCC3,O75600,Q9BWD1,P23786,P27544,Q969G3 9 +Nitrite reductase activity 0.6843711322592196 1.0627120304898086 0.2879125634292485 1.0 0.7322877768551682 4 O43169 1 +Cargo receptor activity 0.550717280120742 1.0540699895360746 0.2918508747504185 1.0 0.738888602201178 8 Q8WTV0 1 +Oligosaccharyl transferase activity 0.6722611436688347 1.015747649564015 0.3097495709906812 1.0 0.7637861021962101 4 Q8TCJ2 1 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.6722611436688347 1.015747649564015 0.3097495709906812 1.0 0.7637861021962101 4 Q8TCJ2 1 +Protease binding 0.4155720958082433 1.0077505132733922 0.3135742483850618 1.0 0.7649186430705838 25 P49841,P41440 2 +Acid phosphatase activity 0.829577361459081 1.0066903522892412 0.3140835998073255 1.0 0.7649186430705838 3 Q9NPH0 1 +Structural constituent of eye lens 0.8280026109660678 1.001169106506525 0.3167450594940026 1.0 0.7686793683663979 3 P36551,P08670 2 +Serine transmembrane transporter activity 0.6639280140738673 0.983554259544279 0.3253347243477531 1.0 0.7785401403521883 4 Q15758,Q96NB2 2 +Exopeptidase activity 0.4103806989592723 0.9636352522288952 0.3352288264135334 1.0 0.7904641446730214 32 P55786,P36551,Q9HB40,O14773,P42785,P09960,Q9H3G5,O75844,Q7Z2K6 9 +Carboxypeptidase activity 0.4749578943233313 0.9376968614700276 0.3484002172066345 1.0 0.7950227178711925 12 P42785,Q9H3G5,Q9HB40 3 +Single stranded dna endodeoxyribonuclease activity 0.7999999999999978 0.9316946812087832 0.3514943359973728 1.0 0.8007553084973261 2 P49959 1 +Metalloexopeptidase activity 0.4236915942698911 0.9214328709103562 0.3568244737229782 1.0 0.8074294688458704 20 P55786,P36551,P09960,O75844,Q7Z2K6 5 +3 5 exonuclease activity 0.4038805290275146 0.9204111285875064 0.3573579553249528 1.0 0.8074294688458704 26 Q9Y3B8,Q13868,Q9GZR2,P49959,Q6L8Q7,Q15024,Q9NQT4,Q9BQ61 8 +Deoxyribonuclease activity 0.4310975361401472 0.9177319567120316 0.3587592128921864 1.0 0.8089310974960878 18 Q9UQ84 1 +Antigen binding 0.5191139600083015 0.9071568938831776 0.3643238352303208 1.0 0.8089310974960878 8 Q15392 1 +Phosphatidylinositol bisphosphate phosphatase activity 0.7934747145187502 0.9070793687436658 0.3643648273259994 1.0 0.8089310974960878 2 Q10713 1 +Protein demethylase activity 0.5180137059660551 0.9020746899723304 0.3670171928325836 1.0 0.8093572244474814 8 Q8NB78 1 +Toxic substance binding 0.7902120717781262 0.8948220517578969 0.3708822202724047 1.0 0.8152299282664999 2 P34913 1 +Beta 2 microglobulin binding 0.7872756933115745 0.8838204315025595 0.3767931552129018 1.0 0.8156181666764801 2 P04439 1 +Nucleotidase activity 0.5224100456448433 0.8812154446452931 0.3782012213926711 1.0 0.8156181666764801 7 Q9NX62,Q969T7 2 +Microfilament motor activity 0.5028680592499384 0.8737723549032678 0.3822422384004964 1.0 0.8184689953045234 9 O00159,Q9Y4I1,Q7Z406,P60660,P35580 5 +G protein alpha subunit binding 0.6336800547216443 0.8678258381154539 0.3854896829425871 1.0 0.8184689953045234 4 Q02818,P80303 2 +Nadh dehydrogenase activity 0.4059444948633499 0.866827354280414 0.3860366118841829 1.0 0.8184689953045234 22 P03915,O95831 2 +Manganese ion transmembrane transporter activity 0.7768352365415918 0.8449466459661407 0.3981406289094815 1.0 0.8376781427820285 2 Q9HD20 1 +Dolichyl phosphate mannose protein mannosyltransferase activity 0.7719412724306669 0.8268631887520618 0.4083146099339745 1.0 0.8499862379260952 2 O60762 1 +Mrna 3 utr au rich region binding 0.4644688691125943 0.81594774970952 0.4145300204359499 1.0 0.855162380989306 11 Q9H2U1,Q06265,Q01085,P31483,Q92945,Q13151,Q14103 7 +Ribosomal protein s6 kinase activity 0.7595432300163059 0.7814839472797502 0.4345179145094344 1.0 0.8680511118727015 2 Q15418 1 +Fatty acid ligase activity 0.4997485309471545 0.7798176179608532 0.435498234709994 1.0 0.8680511118727015 7 P33121 1 +Secondary active transmembrane transporter activity 0.3825495299843773 0.7788606216875974 0.4360618226590893 1.0 0.8680511118727015 24 P41440 1 +Acyl coa oxidase activity 0.7622936977515757 0.7757419023295867 0.4379013935194829 1.0 0.8680511118727015 3 O15254 1 +Mitochondrial ribosome binding 0.6085066559727367 0.7733463115267322 0.4393174546238159 1.0 0.8680511118727015 4 Q92552,Q07021 2 +Arachidonate coa ligase activity 0.5220647382269044 0.7707822420449073 0.4408360146743089 1.0 0.8680511118727015 6 P33121 1 +Long chain fatty acid coa ligase activity 0.5220647382269044 0.7707822420449073 0.4408360146743089 1.0 0.8680511118727015 6 P33121 1 +Transferase activity transferring alkyl or aryl other than methyl groups 0.3846761404589599 0.757490246525723 0.4487562070683619 1.0 0.8726393791190786 23 P49354,P37268 2 +2 acylglycerol 3 phosphate o acyltransferase activity 0.7566860542376215 0.7570775527448108 0.4490034014653399 1.0 0.8726393791190786 3 Q96N66 1 +Long chain fatty acid transporter activity 0.6005430403501235 0.7439074358807887 0.4569324765035527 1.0 0.8757757687696996 4 O14975,P28288 2 +Heme transmembrane transporter activity 0.7491027732463175 0.7437927114274459 0.4570018902814374 1.0 0.8757757687696996 2 O15173 1 +Poly a binding 0.4369576328889824 0.7394891956153463 0.4596099980551766 1.0 0.8757757687696996 12 Q93062,P31483,O14979,Q71RC2 4 +Intramolecular transferase activity 0.4366643197031871 0.7379857442471255 0.4605231120552999 1.0 0.8757757687696996 12 Q96PZ0,O95394,Q6P087 3 +Proton transporting atp synthase activity rotational mechanism 0.4485216024615381 0.7364825431786208 0.4614370874695002 1.0 0.8757757687696996 11 P00846 1 +Proton channel activity 0.4485216024615381 0.7364825431786208 0.4614370874695002 1.0 0.8757757687696996 11 P00846 1 +Active transmembrane transporter activity 0.3222874959804668 0.7323520043131306 0.4639537454629521 1.0 0.8781297850853124 74 P03915,Q9HD20,P06576,P08183,Q9Y5K8,O15439,O00217,P08574,P00403,P28288,P41440,P53985,O43676,P36543 14 +Thiolester hydrolase activity 0.3994288523442721 0.7252606130459709 0.4682921640376052 1.0 0.880217401352375 18 P28288,Q9NUJ1,Q9UMR5,Q68D91 4 +Disulfide oxidoreductase activity 0.3845493238804796 0.725071997659218 0.4684078622880228 1.0 0.880217401352375 22 P30101,Q96JJ7,P07237,Q6ZRP7,Q15084,Q9H3N1,O43396,Q8IXB1,O95881,P13667 10 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.376515612883298 0.7161714429859809 0.4738854939351609 1.0 0.8803889663283992 29 Q9Y3B8,P49959,Q9UQ84,Q15024,Q6L8Q7,Q9NQT4 6 +S100 protein binding 0.4756578677286202 0.7092973531608445 0.478139970607625 1.0 0.8819310986006597 8 P50995,P16615,P31949 3 +Molecular transducer activity 0.3751055574055682 0.7060263334774949 0.4801717613608192 1.0 0.8833106198295284 35 Q99720,Q9UNN8,P30536,Q15629,Q8WTV0,O15173 6 +Calmodulin dependent protein phosphatase activity 0.7376835236541551 0.7031724046581711 0.4819483142704248 1.0 0.8853950339600862 2 P49593 1 +Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor 0.7346171441176068 0.6847781540308805 0.4934839227938177 1.0 0.8981929600056788 3 O43169 1 +Semaphorin receptor activity 0.7295269168026068 0.6745780743581575 0.4999438669730975 1.0 0.9050875277818696 2 O15031 1 +Nuclear localization sequence binding 0.3970513684193215 0.6725737141637013 0.5012185291931575 1.0 0.9050875277818696 15 Q92973,P49790,P35658,A8CG34,P52292,Q14978,P52948 7 +Protein kinase a regulatory subunit binding 0.4656822018269791 0.6650023119542712 0.5060490143377723 1.0 0.9102267238284636 8 Q92667,P17252,O43823 3 +Cytoskeleton nuclear membrane anchor activity 0.7274288844551813 0.6616664352351972 0.5081850202120186 1.0 0.9126305205229556 3 Q8WXH0 1 +Nad binding 0.3682189046278721 0.6575410140106843 0.5108331081310915 1.0 0.9152426520682057 29 P30837,P48735 2 +Nucleosome binding 0.3682368240278043 0.6551662136120562 0.5123607447867853 1.0 0.9167669380850272 35 P10412,O95983,P84243,P07910,P07305,Q8TAQ2,P16402,Q8WXI9,P16403,P18754,O14497,Q9Y6J0,Q969G3 13 +Telomeric dna binding 0.3873934844478542 0.6539867418371107 0.5131203473858199 1.0 0.9167669380850272 18 P19338,Q9NYB0,Q00577,P09651,P22626 5 +N acyltransferase activity 0.3891562798572415 0.6498442387907629 0.515792839835356 1.0 0.9181512905736736 17 P27544,Q96G23 2 +Sulfur compound transmembrane transporter activity 0.457318052054938 0.6283000020992205 0.5298074302658293 1.0 0.9265246132327 8 Q70HW3 1 +Phosphatidylethanolamine binding 0.5075421394490479 0.6169037941324876 0.5372981840963607 1.0 0.9265246132327 5 P50995 1 +Snap receptor activity 0.3868504517295967 0.6164361534519296 0.5376066983168464 1.0 0.9265246132327 15 O95249,P56962,O15400,Q86Y82 4 +Sulfate binding 0.7125611745513842 0.6163373955620118 0.5376718627370576 1.0 0.9265246132327 2 P15586 1 +Ephrin receptor binding 0.4835066945057168 0.6123870503951392 0.5402817074723161 1.0 0.9265246132327 6 P98172 1 +Rna polymerase core enzyme binding 0.3800513795023517 0.5980443320069937 0.5498103530264487 1.0 0.9265246132327 17 Q15061,Q9NQG5,Q8N7H5,Q8N163,Q5VT52,Q5BKZ1,O95104 7 +Phosphatidylinositol phosphate phosphatase activity 0.7051688535636824 0.59165534972249 0.5540814016253099 1.0 0.9265246132327 3 Q10713 1 +Endonuclease activity 0.3591931124451427 0.5881667227423942 0.5564203912334946 1.0 0.9269182304325528 34 O15091,Q9BQG2,P49959,Q15631,Q9UQ84,Q12972,P78549 7 +Kinase activity 0.3578826298833204 0.5843997655584063 0.558951384448285 1.0 0.9270351789733808 121 O14936,P49840,Q13464,P11908,P06493,P24941,P21127,Q12792,P07948,Q14004,Q9BRR6,P49841,P55263,Q96GD4,Q8NI60,P53350,Q9HA64,O14874,Q8WVC6,Q14168,P25440,P17252,O14976,Q15126 24 +Ribonuclease activity 0.3519525398742752 0.5721902430208667 0.5671930968690981 1.0 0.931497946969193 43 O15091,Q9Y3B8,Q9BQG2,Q9UQ84,Q6L8Q7,Q15024,Q12972,Q9NQT4 8 +Gamma tubulin binding 0.4730188927287449 0.570763743462227 0.5681598029256261 1.0 0.9318091642737324 6 Q9H0H5 1 +Annealing activity 0.435244565303799 0.5652400634451505 0.5719104898872622 1.0 0.9357298859510972 9 P46100 1 +Calcium dependent protein binding 0.3711081539854394 0.5599233101370774 0.5755317483308302 1.0 0.938307684482491 18 P20073,P09525,P50995 3 +P type transmembrane transporter activity 0.4880830168831781 0.5443085904541339 0.5862291364704 1.0 0.946303229392082 5 P20020,P35670,P16615 3 +Oxidoreductase activity acting on the ch nh2 group of donors 0.688091353996735 0.5356616575340649 0.5921924074681084 1.0 0.9508246822358426 2 P23378 1 +Nucleotide diphosphatase activity 0.5409915150262895 0.5333853422689931 0.5937668619176113 1.0 0.9511329476119128 4 Q9BW91 1 +Single stranded telomeric dna binding 0.4404415384833516 0.5257218941463102 0.5990814494179042 1.0 0.955198232212093 7 P09651,P22626,Q9NYB0 3 +Adenosine deaminase activity 0.675226963879841 0.5017768227116305 0.6158245183607001 1.0 0.9672547152729988 3 P00813 1 +Oxidoreductase activity acting on ch oh group of donors 0.3182336349261314 0.497019698266043 0.6191751604835465 1.0 0.9703701831723918 57 Q06136,Q14914,Q8N8N7,Q8N4Q0,P48735 5 +Carboxylic acid binding 0.3450591750640854 0.4892481656686769 0.6246660133677953 1.0 0.9734125931648274 33 Q15067,Q32P28,O15460,P41440,O15254 5 +Histone deacetylase binding 0.341786680273042 0.4813794170240492 0.6302468627488673 1.0 0.9734125931648274 28 Q9H2U1,P04637,P45973,Q16512,P23246,P09874,Q96JN0,O43823,P52292,Q14103,P31946,Q13330,Q9UHI6 13 +Exonuclease activity 0.3428428631112912 0.4754599395144884 0.6344591804275823 1.0 0.9734125931648274 37 Q9Y3B8,Q13868,P49959,Q9UQ84,Q6L8Q7,Q15024,Q9NQT4,Q9BQ61 8 +Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor 0.5204609902235385 0.465980027472433 0.6412297967431961 1.0 0.9734125931648274 4 P11177 1 +Cytoskeletal anchor activity 0.4454501651521999 0.4653097388074868 0.6417096616004627 1.0 0.9734125931648274 6 Q9UQB8 1 +Rna polymerase binding 0.3355268278421852 0.4645781408305382 0.6422335891170126 1.0 0.9734125931648274 24 Q15061,Q9NQG5,P27105,Q8N7H5,Q8N163,Q5VT52,Q5BKZ1,O95104 8 +Vitamin binding 0.3363618455275825 0.4604243455687946 0.645211663226068 1.0 0.9734125931648274 44 O94788,Q6P996,Q32P28,O75600,O15460,P13674,P41440 7 +Acid thiol ligase activity 0.4001794576149694 0.4584265668645916 0.646646008595654 1.0 0.9734125931648274 10 P33121 1 +Leucine zipper domain binding 0.6591514161660323 0.4558805609257387 0.6484758688056844 1.0 0.9734125931648274 3 Q6P1K2 1 +Lrr domain binding 0.6591514161660323 0.4558805609257387 0.6484758688056844 1.0 0.9734125931648274 3 Q6P1K2 1 +Vinculin binding 0.4426657954916622 0.4550246381707267 0.6490915136344331 1.0 0.9734125931648274 6 Q9Y3I0,P35221,P12814,Q14118,P46939 5 +Transcription elongation regulator activity 0.6610114192495848 0.4517237476205293 0.6514680081351623 1.0 0.9734125931648274 2 Q15061 1 +Laminin binding 0.5145282402872879 0.4471220568274545 0.6547869342472907 1.0 0.9734125931648274 4 P08865,O94813,Q14118 3 +Extracellular matrix binding 0.5145282402872879 0.4471220568274545 0.6547869342472907 1.0 0.9734125931648274 4 P08865,O94813,Q14118 3 +Translation repressor activity 0.4064385871752018 0.4433818824575194 0.6574895382538926 1.0 0.9734125931648274 9 Q5PRF9,Q00577,Q14011 3 +Laminin 1 binding 0.6515497553017887 0.4238911646374074 0.6716451880166323 1.0 0.9810442694108026 2 O94813 1 +Sphingolipid binding 0.4328607135308551 0.4194099885376866 0.6749165254073115 1.0 0.9826258215070076 6 P21796 1 +Phosphatidylinositol monophosphate phosphatase activity 0.6492659053833503 0.4172973725772773 0.676460910085019 1.0 0.9826258215070076 2 Q13614 1 +Proteoglycan binding 0.6449086161879907 0.4167666830407157 0.6768490740943987 1.0 0.9826258215070076 3 O94813,Q07954 2 +P type calcium transporter activity 0.6479608482871058 0.4135517002318077 0.6792024520506494 1.0 0.9826258215070076 2 P16615 1 +Dioxygenase activity 0.3440977228614617 0.4120414035690053 0.6803090763046644 1.0 0.9826258215070076 18 O15460,Q32P28,P13674,P07237 4 +Acetyltransferase activity 0.3289338296998763 0.4099587577825626 0.6818362015785719 1.0 0.9826258215070076 26 Q9BWD1,P35610,Q969G3 3 +G rich strand telomeric dna binding 0.4298461501006541 0.4086582259540692 0.6827904942678407 1.0 0.9826258215070076 6 P22626,Q9NYB0 2 +Primary active transmembrane transporter activity 0.3202098115359077 0.4075579305404388 0.6835982554790201 1.0 0.9826258215070076 51 P03915,Q9HD20,P06576,P08183,Q9Y5K8,O15439,O00217,P08574,P28288,O43676,P36543 11 +Receptor tyrosine kinase binding 0.3450325098605967 0.4033560498605119 0.6866863139076902 1.0 0.9826258215070076 16 P49354 1 +Lipid binding 0.348245743175479 0.3897109606490225 0.6967502906717096 1.0 0.9826258215070076 131 O94788,Q9H0H5,Q15067,Q9H4L5,Q8WTV0,O15173,P50995,O15254,Q12792,O15118,Q8NCC3,O14773,P28070,A6NIH7,Q9Y6I3,P35080,P56589,P21796,P09525,Q7Z3T8,P30536,P20073,P35610,P08133 24 +Pre mrna intronic binding 0.4431336695378594 0.3881975991034092 0.6978698097695102 1.0 0.9826258215070076 5 P22626 1 +Double stranded telomeric dna binding 0.4225889509614802 0.3831785614263056 0.7015873726866293 1.0 0.9826258215070076 6 Q00577,Q92878 2 +Exoribonuclease activity producing 5 phosphomonoesters 0.3316103171547244 0.3802974234613465 0.703724647887841 1.0 0.9826258215070076 21 Q9Y3B8,Q9NQT4,Q6L8Q7,Q15024 4 +Retinoic acid receptor binding 0.4217575955570139 0.3802972614993044 0.7037247680999326 1.0 0.9826258215070076 6 O43707,P17096,P56545,Q15648,Q13573 5 +Phosphatidylinositol kinase activity 0.632300163132129 0.3699031471604784 0.7114546564170161 1.0 0.9826258215070076 2 Q9BTU6 1 +Integrin binding 0.3341107146418223 0.3606468934396536 0.7183634292875982 1.0 0.9826258215070076 18 P20073,P17252,P07942,P07237 4 +Protein tyrosine serine threonine phosphatase activity 0.481510692201177 0.3480148754540809 0.7278290119871542 1.0 0.984064249283112 4 P49593,Q99956 2 +Protein phosphorylated amino acid binding 0.3411598053662064 0.3328090234563499 0.7392784464357727 1.0 0.984064249283112 13 O95104 1 +L serine transmembrane transporter activity 0.6110579665172791 0.3303352339436531 0.741146672912617 1.0 0.984064249283112 3 Q15758 1 +Beta tubulin binding 0.3263984758315797 0.3297350257252104 0.7416001857907102 1.0 0.984064249283112 19 Q9H0H5,O75381 2 +Translation activator activity 0.4192890169688568 0.3137430761155584 0.7537161814183841 1.0 0.9877271101254252 5 Q7Z478 1 +Ribosomal small subunit binding 0.3539418532599343 0.3090558397647673 0.757279050542617 1.0 0.9905094805576437 11 Q96EY7,P23588 2 +Pdz domain binding 0.3432375891552963 0.3017895265795285 0.762812515426559 1.0 0.9949099727269624 12 Q9UBI6,Q15067 2 +Protein tyrosine kinase binding 0.3173062606924631 0.293066471993887 0.7694713436261458 1.0 1.0 20 P49354 1 +Tropomyosin binding 0.5904719193765147 0.2827445343435614 0.777372675097352 1.0 1.0 3 Q9NYL9 1 +Metal ion transmembrane transporter activity 0.3061765791262839 0.2750949046616219 0.7832433261112379 1.0 1.0 26 Q6P4Q7,Q8TAD4,P08133,Q9HD20 4 +Metalloaminopeptidase activity 0.3352430733390155 0.2703859125170604 0.7868633768066204 1.0 1.0 12 P09960,P55786 2 +Structural constituent of nuclear pore 0.3062460005612471 0.2479779925652773 0.8041514344732237 1.0 1.0 21 Q9BTX1,Q12769,P49790,P12270,A8CG34,P35658,Q8NFH5,Q8N1F7,Q9BZI7,Q9BW27,Q7Z3B4,Q99567,P52948 13 +Catalytic activity acting on dna 0.2852029910461703 0.2474353333860988 0.8045713320432373 1.0 1.0 83 P46100,Q9UQ84,P41440 3 +Atpase binding 0.3021379393895921 0.2463864705521165 0.80538307842088 1.0 1.0 27 Q8IXB1,Q16740,Q93050,P36543 4 +Dystroglycan binding 0.4404178909565788 0.2408746654752562 0.8096522581142054 1.0 1.0 4 Q14118,Q7Z460,Q15149 3 +Profilin binding 0.4385664876061547 0.2365247205226274 0.8130255271773883 1.0 1.0 4 Q8N8S7,Q14247 2 +Phosphatase inhibitor activity 0.3555382084241777 0.2346980725106167 0.8144430838702708 1.0 1.0 8 Q96QC0,O43768,Q9Y6J0,Q12972,Q01105 5 +Mrna methyltransferase activity 0.3844835151808858 0.2180947831016491 0.8273552620574167 1.0 1.0 5 Q96FX7 1 +Translation repressor activity mrna regulatory element binding 0.3684537344783825 0.2142736809429506 0.8303336409614233 1.0 1.0 6 Q00577 1 +Coa hydrolase activity 0.3434992977819353 0.2129632539807378 0.8313556242742739 1.0 1.0 9 O14734,P28288,Q68D91 3 +Sequence specific single stranded dna binding 0.3480371563417118 0.2112585261680508 0.8326855438542344 1.0 1.0 8 P09651,P22626,Q9NYB0 3 +Phospholipid binding 0.2817848007463684 0.2064677161789129 0.8364255801951792 1.0 1.0 84 P35080,P20073,Q12792,P21796,Q8NCC3,Q9H0H5,O14773,P09525,Q7Z3T8,P08133,Q9Y6I3,Q8WTV0,P50995 13 +Gdp binding 0.2957610477011965 0.2061662948324665 0.8366610150848723 1.0 1.0 28 P61020,Q13636,P11908,P51151,P20339,P61106,Q9NQG6 7 +Adp binding 0.2971408272604207 0.193634872669953 0.8464617905047542 1.0 1.0 19 Q8NI60 1 +Catalytic activity acting on a rrna 0.3454248366013096 0.189294276872149 0.849862180633185 1.0 1.0 7 Q9UNQ2,P22087,P46087,Q8IY81,Q92979,Q96P11 6 +Phospholipase a2 inhibitor activity 0.5484502446981914 0.1824476588128049 0.8552314270666519 1.0 1.0 2 P07355 1 +Phosphatidylinositol phosphate binding 0.290412405309398 0.1729206451768817 0.8627138036009043 1.0 1.0 29 P35080,Q9H0H5,Q12792 3 +Phosphoprotein binding 0.2889113423787913 0.1709008642787585 0.8643017170652547 1.0 1.0 28 Q9Y3B8,O95104 2 +Oxidoreductase activity acting on nad p h 0.2914502967136516 0.1642627639789437 0.8695242935199221 1.0 1.0 32 P03915,O95831 2 +Inorganic molecular entity transmembrane transporter activity 0.2714636633166574 0.1628215866743318 0.870658911364901 1.0 1.0 79 P00846,Q9HD20,P06576,Q6P4Q7,P21796,Q13423,Q8TDW0,Q9Y5K8,Q9UM00,O15439,Q8TAD4,Q93050,Q6N075,P08574,P08133,Q8IWT6,P00403,P36543 18 +Atp dependent activity acting on dna 0.2854049858476703 0.159218363403587 0.8734968365089628 1.0 1.0 52 P41440 1 +Pre mrna binding 0.2886075881032365 0.1571350821322697 0.8751383894650533 1.0 1.0 18 Q15637,Q9BWF3,P17844,Q13247,P09651,Q92879,P62995,P22626,O95319 9 +Cation channel activity 0.2859815513031663 0.1556566801794147 0.8763036450690456 1.0 1.0 21 P08133,P00846 2 +Lamin binding 0.3273387181085586 0.1518548985538142 0.87930138138855 1.0 1.0 8 P42167,Q14739,Q9UH99 3 +Hexosyltransferase activity 0.2875057792405176 0.1483977006364656 0.8820289146081108 1.0 1.0 31 Q13126,Q8NAT1,Q8TCJ2 3 +Arp2 3 complex binding 0.3950375448906307 0.1472363313433684 0.8829454848174738 1.0 1.0 4 Q9BR76,Q13576,Q9Y5X1 3 +Phosphatidylinositol 4 5 bisphosphate binding 0.2994552243556024 0.1467317174368947 0.883343782662797 1.0 1.0 12 Q12792 1 +Peptide alpha n acetyltransferase activity 0.3917727717923648 0.1415727031188788 0.8874175294771098 1.0 1.0 4 Q9BXJ9,P41227,Q86UY6 3 +Nuclease activity 0.2556147300301739 0.1398418673292407 0.8887849329444188 1.0 1.0 67 O15091,Q9Y3B8,Q9BQG2,Q13868,P49959,Q15631,Q9UQ84,Q6L8Q7,Q15024,Q9NQT4,Q12972,Q9BQ61,P78549 13 +Misfolded protein binding 0.3025407002237007 0.1344298541832116 0.893062675658006 1.0 1.0 11 Q13217,Q8IXB1 2 +Fibronectin binding 0.5141924959216866 0.1302988466970893 0.8963299924943013 1.0 1.0 2 Q53GQ0 1 +Protein phosphatase 2a binding 0.3073605517373005 0.127963635457745 0.8981777510976128 1.0 1.0 10 Q86XL3,P78318 2 +Structural constituent of muscle 0.3325590508102408 0.1270057669600326 0.8989358341415228 1.0 1.0 6 P67936,P60660,Q15149 3 +Exoribonuclease activity 0.2728228319625603 0.1216535646126917 0.9031733900621725 1.0 1.0 24 Q9Y3B8,Q9NQT4,Q6L8Q7,Q15024 4 +Complement binding 0.4960835509138302 0.1196433583239427 0.9047656714195528 1.0 1.0 3 Q07021,P35232 2 +Opsonin binding 0.4960835509138302 0.1196433583239427 0.9047656714195528 1.0 1.0 3 Q07021,P35232 2 +Thiol oxidase activity 0.4950246826959292 0.1183454477195378 0.9057939483190957 1.0 1.0 3 P07237 1 +Aminoacyl trna editing activity 0.3016303439779977 0.1129949607200435 0.9100345503904744 1.0 1.0 10 Q9NSE4,Q5ST30 2 +Notch binding 0.4998368678629507 0.1126296639926402 0.9103241662168378 1.0 1.0 2 Q13618 1 +Clathrin binding 0.2749431056084083 0.1112195092123087 0.91144228149519 1.0 1.0 21 P53680,Q5VW38,O14976,Q9Y6I3 4 +Complement component c1q complex binding 0.4959216965742063 0.108222132850165 0.913819488588292 1.0 1.0 2 Q07021 1 +Lipase binding 0.4952691680260875 0.1075043261723392 0.9143888934253694 1.0 1.0 2 Q96CS3 1 +Ribonuclease p rna binding 0.4923327895595309 0.1043329797830877 0.9169051066397962 1.0 1.0 2 Q99575 1 +Cation chloride symporter activity 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 1.0 2 Q9Y666 1 +Potassium chloride symporter activity 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 1.0 2 Q9Y666 1 +Ammonium transmembrane transporter activity 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 1.0 2 Q9Y666 1 +Dopamine receptor binding 0.3282168517308933 0.1017855399880816 0.9189269034523015 1.0 1.0 5 P50570,Q15334,Q9Y5X3,Q14344 4 +Mitogen activated protein kinase binding 0.318596842059495 0.0990732381833089 0.921080120363502 1.0 1.0 6 P12270 1 +Adenylyltransferase activity 0.3256041802743291 0.097607056912385 0.9222443206619126 1.0 1.0 5 Q8NFF5,O43252,P51003,Q9NVV4 4 +Histone methyltransferase binding 0.3065605376297107 0.0928366543533318 0.9260333307789156 1.0 1.0 7 Q96JN0,P35222,Q13185 3 +Sh3 domain binding 0.2673374965704613 0.0831911584685936 0.9336995428907384 1.0 1.0 18 P07948,Q14185,O75525,Q16204,Q07960,P42566 6 +P type potassium transmembrane transporter activity 0.4561174551386534 0.0726691870063453 0.9420693689060052 1.0 1.0 2 P05026 1 +Udp glucosyltransferase activity 0.4484334203655316 0.0722106227265763 0.942434291531582 1.0 1.0 3 P13807,Q9NYU2 2 +Basal transcription machinery binding 0.2626698437416852 0.072166354942319 0.9424695202020548 1.0 1.0 25 Q15061,Q9NQG5,Q8N7H5,Q8N163,Q14978,Q5VT52,Q5BKZ1,O95104 8 +Cyclin dependent protein serine threonine kinase regulator activity 0.4470463122284292 0.0711473922273748 0.9432804501664204 1.0 1.0 3 P14635 1 +Peroxisome proliferator activated receptor binding 0.4515497553017889 0.0695795202071462 0.9445283379342706 1.0 1.0 2 Q15648 1 +Interleukin 1 receptor binding 0.4267536704730766 0.0558432740206658 0.955466661025814 1.0 1.0 2 Q9NZ08 1 +Acetyl coa hydrolase activity 0.42362924281985 0.0556075293668994 0.9556544662207676 1.0 1.0 3 O14734,P42765 2 +Proton transmembrane transporter activity 0.2715585484665454 0.0546359590225649 0.9564284903741008 1.0 1.0 36 P00846,Q13423,P06576,Q9Y5K8,Q93050,P08574,P36543 7 +Single stranded dna 3 5 exodeoxyribonuclease activity 0.422838499184335 0.0541011741492495 0.9568545567836306 1.0 1.0 2 Q9NVH0 1 +Calcium dependent protein serine threonine phosphatase activity 0.40755074739379 0.0473491488917685 0.9622349568311768 1.0 1.0 3 P49593 1 +Ribosomal large subunit binding 0.2816111184305553 0.0463146585856357 0.9630594559850908 1.0 1.0 7 P98179 1 +Single stranded rna binding 0.2686803946535345 0.0392390311372664 0.9686998152379896 1.0 1.0 37 Q96SI9,Q93062,P07910,Q9Y606,P52597,P23588,P09651,Q96KR1,Q71RC2 9 +Eukaryotic initiation factor 4e binding 0.3789164490861639 0.0367033627147626 0.9707215273927036 1.0 1.0 3 Q04637,O00571 2 +Active ion transmembrane transporter activity 0.2698014262699605 0.0363184411550331 0.9710284457241278 1.0 1.0 44 Q9HD20,P06576,Q9Y5K8,O15439,P08574,P41440,P36543 7 +Aspartic endopeptidase activity intramembrane cleaving 0.3455138662316445 0.0361713372904083 0.9711457405564908 1.0 1.0 2 Q92542 1 +Rrna adenine methyltransferase activity 0.3448613376835243 0.0361117728409099 0.97119323508202 1.0 1.0 2 Q9UNQ2 1 +Rna polymerase ii activity 0.3386623164763427 0.0355918953992656 0.9716077707633756 1.0 1.0 2 P24928 1 +5 deoxyribose 5 phosphate lyase activity 0.3233278955954338 0.0346152265514435 0.9723865597440332 1.0 1.0 2 P12956 1 +Nucleoside monophosphate kinase activity 0.2687252831669981 0.0329822659912732 0.973688729636037 1.0 1.0 9 O14936,Q14168 2 +Camp dependent protein kinase activity 0.3410256044333972 0.0286741345003768 0.977124485561542 1.0 1.0 3 P17252 1 +Cyclic nucleotide dependent protein kinase activity 0.3410256044333972 0.0286741345003768 0.977124485561542 1.0 1.0 3 P17252 1 +Alpha actinin binding 0.2540822991508809 0.0223494427844639 0.9821692090782757 1.0 1.0 5 Q96HC4,Q8WX93,Q14118,O00151 4 +Vitamin b6 binding 0.2437975406495315 0.0193161579956147 0.9845888941170192 1.0 1.0 18 O75600,Q5VT66,Q6P996,P34897 4 +Actinin binding 0.2541653054557332 0.0134479457193843 0.989270415139605 1.0 1.0 6 O00151,Q8WX93,Q14118,Q96HC4,Q16527 5 +Atpase activator activity 0.2441021990211553 0.0098595527507745 0.9921333425379272 1.0 1.0 11 Q8IXB1,Q99543 2 +Nadplus binding 0.2255549453703923 0.0095152612512183 0.992408034518828 1.0 1.0 5 Q16836,P40939 2 +Oxidoreductase activity acting on a heme group of donors 0.2426384220221944 0.0048488990864367 0.9961311534426524 1.0 1.0 6 P00403 1 +Pre mirna binding 0.2070542129327228 0.0046418305817096 0.9962963683451024 1.0 1.0 5 Q9H2U1,O75569,Q9UPY3,Q9HAV4 4 +C4 dicarboxylate transmembrane transporter activity 0.1955245816665984 0.0026086841267085 0.9979185735720532 1.0 1.0 5 Q15758 1 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..459f61e9e0cd577d52cf588f47e88215944ff5f5 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 3 kinase regulator activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 cyclic amp phosphodiesterase activity", "3 5 cyclic gmp phosphodiesterase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5alpha androstane 3beta 17beta diol dehydrogenase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Activin binding", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Aminophospholipid flippase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Ap 2 adaptor complex binding", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp gated ion channel activity", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Bile acid transmembrane transporter activity", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbohydrate transmembrane transporter activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Copper ion transmembrane transporter activity", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Corticotropin releasing hormone receptor binding", "Crossover junction endodeoxyribonuclease activity", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D glucose transmembrane transporter activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Dehydroascorbic acid transmembrane transporter activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gap junction channel activity", "Gap junction hemi channel activity", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophosphodiester phosphodiesterase activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Icosanoid binding", "Identical protein binding", "Igg binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated cation channel activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Mutsalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Narrow pore channel activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neuropeptide receptor binding", "Neurotransmitter binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opioid receptor binding", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidic acid transfer activity", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 4 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphorylation dependent protein binding", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Platelet derived growth factor receptor binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Salt transmembrane transporter activity", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sugar transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Superoxide generating nadph oxidase activator activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type 5 metabotropic glutamate receptor binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AAMP", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPIF1", "ATR", "ATRX", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC137", "CCDC22", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLM", "GCN1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOPC", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS4", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAM3", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1147", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MPV17", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFKB2", "NFU1", "NGEF", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTF1", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM201", "TMEM30A", "TMEM41B", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPO", "TSR1", "TST", "TSTA3", "TTC1", "TTC21B", "TTC26", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS18", "VPS25", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS50", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WNK1", "WTAP", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABCD3", "ABHD10", "ACAA2", "ACAT2", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACTN1", "ACTN4", "ADA", "ADK", "ADPGK", "ADSS", "AFG3L2", "AIFM1", "AKAP1", "AKAP8", "ALDH1A2", "ALDH1B1", "ANKLE2", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP2S1", "ARHGAP1", "ARID1A", "ATP13A1", "ATP1B1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6", "ATP6V0A1", "ATP6V1D", "ATP6V1E1", "ATP7B", "ATRX", "AURKB", "BAIAP2", "BCKDK", "BRD2", "C1QBP", "CABIN1", 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0.4759178318654418 +Abnormal femoral neck morphology 6 37 2.2754153942413597 0.0228810227623694 9.25242718446602 36.74029126213592 0.6712343390867015 0.4697291762664369 3.621586968033212 4.796644044529848 0.9043918120717824 0.3346762025558714 0.1614786837419347 0.0904452781629929 0.0035004373075969 0.0137128382989162 0.1374763991753785 +Intellectual disability progressive 2 12 2.2727698640220497 0.023040051989871 3.645631067961165 12.516990291262136 0.6684697128447727 0.4789280824963769 2.065823454097857 2.417011447989348 0.7882243058155131 0.3050220610121475 1.0 0.1835089509173778 0.0625314301217693 0.0808776862517318 0.3340933889960909 +Mitochondrial respiratory chain defects 2 5 2.2532150910993103 0.024245590334007 1.8033980582524272 5.177184466019417 1.0048180638921334 0.285673153216041 1.1353491002390874 1.0681459460620504 1.0953831291184488 0.2879410254685434 1.0 0.0026008925831016 0.0102498345034834 0.0062267265321947 0.0397387250697101 +Round face 1 17 2.252644638768887 0.0242815641673552 5.186893203883495 19.3495145631068 -0.0230946085095229 0.6120701996461332 3.041225330827434 3.1675194357732845 0.8383552184856793 0.2946833021028764 0.1254250484281346 0.0564048148733258 0.1821593613874541 0.5811837748974361 0.7527687502855307 +Fatigable weakness of respiratory muscles 5 13 2.24935283009585 0.0244900571269508 3.781553398058252 14.49514563106796 0.6722462704336608 0.4649039538010518 2.229730602074667 1.5192856420985286 0.8723926977398212 0.3188845594433921 1.0 0.1675604235637086 0.0523352985295366 0.0130060888805635 0.0093317531476842 +Abnormal upper motor neuron morphology 1 8 2.2341679974081523 0.0254720212804555 2.104368932038835 10.152912621359222 0.6668580581129538 0.4264480473015415 1.810508789672501 1.2708136152843803 0.93546763978058 0.305632736845798 1.0 0.083126337411673 0.1611939416425752 0.0693365470158766 0.2166689846253057 +Abnormal diaphysis morphology 12 61 2.217613316560223 0.0265812091384261 14.83980582524272 66.9878640776699 0.4527821244506883 0.5906467269591996 5.107444401245179 8.468522429377211 0.7856437055190839 0.340884591252888 0.0472750505508048 0.0182713904115901 0.0166742060342669 0.1405495619932706 0.225783032188507 +Wide cranial sutures 1 7 2.210693048358495 0.0270571002553186 2.0145631067961167 7.703883495145631 0.7152221419680245 0.3932675421341624 1.400340303092121 0.8783725385755785 0.8965275088954128 0.2767752142477642 0.0263652723860263 0.0742352733278267 0.0102498345034834 0.0561137872346343 0.0397387250697101 +Talipes calcaneovalgus 2 5 2.204237084339832 0.0275076750099116 1.4902912621359223 4.922330097087379 0.9197709073874 0.3393743205084361 1.020376340538831 1.1900829732707392 0.926051379506817 0.2775113358333487 1.0 0.0424464003246627 0.0032139762811053 0.0188064524051028 0.0076703518288617 +Upper airway obstruction 1 5 2.193501163577233 0.0282712908467785 1.7378640776699028 4.395631067961165 0.9757524179748694 0.272585161266212 1.0188625396632285 0.5317860908423824 1.0518772900465188 0.2586596530104152 1.0 1.0 0.0067896670197663 0.0382400085743442 0.1289341732663725 +Hammertoe 3 17 2.184452533839785 0.0289290115483737 3.662621359223301 18.046116504854368 0.6966488433366873 0.4834332623162832 2.346296590711119 2.471254047837027 0.8432277041521599 0.3207676556555462 1.0 0.0157111699130222 0.0573531962335191 0.0720513532108381 0.1274755097437061 +Vertebral compression fracture 2 16 2.168614018004676 0.0301120000254129 3.718446601941748 15.771844660194176 0.638605685637545 0.4585378455721924 1.8270750975800616 1.3728941491613926 0.8197174983565503 0.2921971535023096 0.0425098423004131 0.0068317681715133 0.0019631407021181 0.0242110622206542 0.0074494564855197 +Rhizomelia 3 10 2.165367264938617 0.0303595708670494 4.276699029126213 11.868932038834952 1.3783619481702345 0.228956695884812 2.09278482575067 1.6655579622091714 0.936017394236602 0.2616202806826952 0.0740460665995901 0.1991580424676108 0.0733374275738533 0.0998367022916053 0.0707827064406983 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17.730582524271846 1.450228655394427 0.2143723456093393 2.356374883616516 2.3878203593303375 1.2019998086948689 0.268108115907532 1.0 0.01497108596825 0.0548237001435711 0.0142235096743441 0.0105883475769395 +Abnormal pupillary function 0 7 2.1472789673791404 0.0317710792344536 1.7985436893203883 6.25 0.9459174425459445 0.2892194993230557 1.1928988171245156 1.7202745886032773 1.109204161812943 0.2732247962160634 1.0 0.1389130578490434 0.2613412907301976 0.5329697587184232 0.7867081306042436 +Abnormal neuron morphology 4 26 2.1455975223135813 0.0319051032981385 6.186893203883495 28.24514563106796 0.6484714329574719 0.4735595458743487 3.2896606279139218 2.2567268866496706 0.9337112301481814 0.3347227917865519 1.0 0.0421554091664212 0.028249351231176 0.0242455864981032 0.0166822263622692 +Tinnitus 3 15 2.1454101337474603 0.0319200695781196 3.8932038834951457 13.99514563106796 0.4805222542355059 0.4721664152250915 2.15835527708504 1.954575346364738 0.945493760855854 0.2980035751111249 1.0 0.0157111699130222 0.0573531962335191 0.0155108289838298 0.1274755097437061 +Head tremor 2 13 2.145253424834332 0.0319325901677216 2.9563106796116503 13.3252427184466 0.4342055003305567 0.5012574626709954 2.027249794357098 1.0932465631703912 0.9190385225705504 0.3021636126820415 1.0 0.1135912525516411 0.2166826538338764 0.1219531221716571 0.1188827437046941 +Toe walking 6 21 2.135649315168258 0.032708008567613 6.740291262135922 22.805825242718445 1.1386089770349623 0.3130572717722256 3.272869930973316 2.572476621751866 1.068544148592376 0.2998505070337083 1.0 0.0248381956323572 0.0876106046642714 0.1257511849434855 0.0110551101007063 +Supranuclear gaze palsy 2 15 2.130087375867626 0.0331644003688753 5.186893203883495 19.1626213592233 0.8242716574954257 0.3183493558985887 2.2612229396433574 2.139608194404574 1.2188387108542005 0.2935859783151378 1.0 0.1715759324473242 0.3169879022746943 0.2436114581565515 0.2936288791787133 +Toxemia of pregnancy 1 6 2.1291913680045336 0.0332384307842308 1.4878640776699028 5.800970873786408 1.2181595126321945 0.2438445067902855 1.0938256996143263 0.5566883958063523 0.8280220660434614 0.2316195823412623 1.0 0.0561990347849709 0.1105474823156849 0.0328731354880699 0.1125747569923622 +Disproportionate short limb short stature 6 17 2.125831042938433 0.0335173302379365 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.1076057072869973 0.0421554091664212 0.028249351231176 0.0824194625829831 0.0460574281433519 +Abnormal morphology of the musculature of the neck 1 12 2.120188431325228 0.033990157638098 2.6237864077669903 13.473300970873789 0.6063883248814701 0.4967060238844604 1.853026187474353 1.6726717703016651 0.7926132510244637 0.3017521656103346 1.0 0.1755724648168266 0.3236452024265956 0.2526409373615763 0.5850817530243546 +Onion bulb formation 0 7 2.119863094929561 0.0340175924785559 2.349514563106796 7.970873786407767 0.5150646293879767 0.4549381092129949 1.538873234646762 1.9506350008138953 0.9326070078767312 0.299017222140306 1.0 0.1006582454154426 0.1933613304033528 0.4172977923286156 0.6658017842410733 +Abnormal circulating fatty acid concentration 4 19 2.1069176431367427 0.0351247190001842 5.851941747572815 19.300970873786408 0.8709428538401427 0.3748768442629192 3.3070858195646933 2.246183176686473 0.9913820617853404 0.2893310559059322 1.0 0.1835089509173778 0.3367676981326228 0.0808776862517318 0.051296284939533 +Motor neuron atrophy 4 21 2.096239837755261 0.0360609206396353 5.410194174757281 22.424757281553397 0.8356342611289532 0.3959768073616548 2.754377444710008 1.6813276911909307 0.954775311801755 0.3176984078794489 1.0 0.0239365913088697 0.0125141686162342 0.006984722202598 0.0025854516113679 +Postural instability 1 18 2.092780134508064 0.0363687859530446 3.533980582524272 17.79126213592233 0.4509430795614677 0.5268149729159746 2.1579185133601717 2.125919871541916 0.8315457301240203 0.299833681390129 1.0 0.0315268496209905 0.1088269092294783 0.4120011086653588 0.5396622799916891 +Abnormal circulating citrulline concentration 2 5 2.0737821684211792 0.0380995459601061 1.519417475728155 4.283980582524272 0.9322911204120568 0.2795135602214257 1.0297099461920487 1.0355035731992424 1.235992875942202 0.2843671782204088 1.0 0.0561990347849709 0.1105474823156849 0.00262770885776 0.018020673376298 +Equinovarus deformity 0 5 2.0724497272415583 0.0382235199812717 1.6019417475728157 5.201456310679611 0.5878066527272209 0.4188147239684637 1.2294114609421758 0.9881324031472178 1.0021081641648737 0.306259169635257 1.0 0.0470522829573702 0.0930016660897952 0.2175647207167039 0.3921885014959403 +Dolichocephaly 7 25 2.0536222584815103 0.0400122661172253 8.254854368932039 32.99271844660194 0.3115867009615017 0.6117064857723883 3.190641766432611 7.582071686330195 0.7651955171401985 0.305025362921914 1.0 0.5171039221757672 0.4293801630841931 0.2985878472365116 0.5973419093645349 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0.6345115539557413 2.9345734238778345 2.623779671816255 0.7136376301986084 0.2766617941880244 1.0 0.0527005247489921 0.1717287687817776 0.0386631533679294 0.1700618733952761 +Abnormality of the pulmonary veins 1 6 2.0404888349678414 0.0413016619538662 1.2135922330097086 6.669902912621359 0.9535622979003926 0.3793496965363341 1.175399006302687 0.7806936113776552 0.7920022166500139 0.2937792263138297 0.0568242148228825 0.1553991536419083 0.045127039841821 0.2076979954646016 0.5122684088981724 +Multiple prenatal fractures 4 7 2.0306916012332645 0.0422862888706336 2.133495145631068 6.592233009708738 0.8339635044673502 0.3927176527212103 1.278707029562348 0.9747978949493776 0.8175122325077913 0.2896660614910132 0.0214721625357582 0.0017062060788896 0.0067896670197663 0.003355333516566 0.0002457979454447 +Abnormal circulating bilirubin concentration 6 26 2.0275072494864497 0.0426105638117084 6.611650485436893 26.725728155339805 0.4812850312626911 0.5974382444384296 3.1729530813550246 1.934615238303275 0.7143081068469757 0.3163768833940157 1.0 0.2183067054048652 0.0876106046642714 0.0075944976014186 0.0110551101007063 +Abnormal epiphyseal ossification 4 15 2.020863325230743 0.0432939153165348 6.451456310679611 16.274271844660195 1.1227269321938518 0.3276999393402902 3.140724178369711 2.4155680760400804 1.043634905787503 0.3148370578580727 1.0 1.0 0.3496381161424667 0.0901467992310857 0.0605931687414638 +Spondyloepimetaphyseal dysplasia 1 5 2.012551316968139 0.0441618528916674 2.046116504854369 6.87378640776699 0.6291617473675466 0.4421176103682042 1.294240214952168 1.435876050377699 0.927363068507802 0.3097679752285407 1.0 0.0561990347849709 0.0057815105752346 0.0328731354880699 0.018020673376298 +Inverted nipples 4 9 2.011346816169231 0.0442888367265155 2.825242718446602 7.560679611650485 0.5742526021095823 0.4293603144776698 1.7358425081015891 2.1819443374032397 1.0022452058355265 0.3096465985683321 1.0 1.0 1.0 0.1724444479617574 0.1889957663081205 +Aplasia hypoplasia of the femur 1 12 2.0112074937235462 0.0443035445822184 4.206310679611651 14.701456310679612 0.6489043589718527 0.4831511175821769 2.1606945531522657 1.8800686352721176 0.788729448753014 0.3050726960031586 1.0 0.1594721229818057 0.0474859144951228 0.2166326226637888 0.5274882304980407 +Abnormal circulating non proteinogenic amino acid concentration 2 7 1.9962900511878192 0.0459023603322641 2.162621359223301 6.968446601941747 0.7521093084296674 0.2992197670299059 1.410866607722538 1.225329167014724 1.1887948503174883 0.2730524920497975 1.0 0.0697581245313758 0.1362380906066266 0.0051503840765812 0.0334620993119388 +Cutaneous photosensitivity 7 23 1.9915976249538905 0.0464152241826918 4.45873786407767 23.25728155339806 0.4951941865269984 0.5365203315345327 2.635778170171519 2.496953559053009 0.8423686703892482 0.3178790898940878 1.0 0.2480154974279715 0.0195000915431133 0.0138556470380734 0.0073008402117251 +Abnormal circulating long chain fatty acid concentration 2 5 1.990301916231546 0.0465576870606976 2.0728155339805827 4.861650485436893 1.0288291622755297 0.284696092465088 1.384567800831184 1.563474222630441 1.0358408470651057 0.2764983518284591 1.0 1.0 1.0 0.062605312422627 0.0465653262864464 +Shawl scrotum 3 6 1.9888856929807697 0.0467138212875348 1.4854368932038835 5.203883495145631 0.1656273830340845 0.5954901587267709 1.32646019683386 0.9280862792684874 0.7376991923826736 0.2700493887790191 1.0 1.0 0.144637307685789 0.0062267265321947 0.0062633876942655 +Tremor by anatomical site 5 25 1.9768434151967225 0.0480593325324809 5.689320388349515 26.490291262135923 0.4232959081978404 0.5931090687196263 3.262850996522312 2.2976144049864677 0.8071150168474217 0.3228311856054389 1.0 0.0248381956323572 0.0876106046642714 0.1257511849434855 0.0359869143678365 +Muscle fiber atrophy 7 19 1.9679449682528936 0.0490743699946252 5.444174757281553 20.281553398058257 0.7686173455615849 0.4552894087545087 2.6272082803045267 1.888480540541262 0.8113647632820095 0.320700919049039 1.0 0.1991580424676108 0.3622612502953293 0.0247625444605767 0.0014891058006406 +Abnormal femoral neck head morphology 7 45 1.9657261843447809 0.049330248483582 11.097087378640778 44.88834951456311 0.710356821644891 0.4647128189516342 4.081724752298962 5.521112188696193 0.9531654138623804 0.3489729073692786 0.1920442159317599 0.1241751068215353 0.0078010707354498 0.0119730212555877 0.1640104998874151 +Neurogenic bladder 2 6 1.961692231566596 0.0497983268210699 2.558252427184466 7.684466019417476 0.1897186564239942 0.5956927880422473 1.6704179043327654 2.3405358809491403 0.7947467348521934 0.2955528066835273 1.0 1.0 0.2613412907301976 0.5329697587184232 0.1889957663081205 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..20cc922a0fba3dfa04d9df0ecd0b85d76e974789 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 4548, + "title": "Average number of proteins per term", + "value": 22.79045734388742 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2db05e9484fa6a8353f6810d874b14830c3fec95 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1b0b580e426b10b6d163c45daca07a6bee304618 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1244 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Peripheral demyelination 0.7617692139931284 2.775560230115638 0.0055106691227491 0.9999999999878274 0.6254681659545941 16 Q9NR77,P00846 2 +Coxa vara 0.8207128196286954 2.702389667390466 0.0068843028459497 0.9999999999999774 0.6254681659545941 12 O75718,O95831 2 +Distal muscle weakness 0.5174759211551078 2.697596450485044 0.0069842049215538 0.9999999999999856 0.6254681659545941 62 Q9Y4W6,P00846,P36551,Q9NR77,Q9BQT8,O95831,Q99720,P35637,P41440,P39210 10 +Abnormality of the calf 0.5568267646952079 2.673266803981054 0.0075116481481876 0.9999999999999988 0.6254681659545941 55 O75718,Q9NR77,Q13126,O95831,Q32P28,Q96HY6 6 +Bulbar signs 0.7753487827283589 2.6162024557658987 0.0088913820320355 1.0 0.6254681659545941 13 Q99720,P03915,P00846 3 +Aplasia hypoplasia involving the pelvis 0.8232777137705228 2.592019988320102 0.0095414227771608 1.0 0.6254681659545941 11 Q96HY6,O95831 2 +Abnormality of skull ossification 0.79725809096701 2.591729742016486 0.009549475666043 1.0 0.6254681659545941 12 Q32P28,O75844,P54802,O75718 4 +Aplasia hypoplasia involving the femoral head and neck 0.9098871179492942 2.5850624798062367 0.0097361352557938 1.0 0.6254681659545941 7 O95831 1 +Abnormality of hepatobiliary system physiology 0.4926176740060506 2.5769551847441496 0.0099674872688613 1.0 0.6254681659545941 77 P00846,P03915,Q8TCJ2,Q9Y619,Q10713,P22695,O15118,P22830,O43772,O75381,O15460,P23786,P28288,Q8N511,P55263,P39210,P46100,Q16625 18 +Amyotrophic lateral sclerosis 0.732128021860688 2.5758965150894273 0.0099980564450368 1.0 0.6254681659545941 15 Q96CV9,Q15165,Q92804,Q99720,P35637,P22626,P50995 7 +Abnormal muscle fiber morphology 0.4773983853991941 2.5492147321286835 0.0107965799670037 1.0 0.6254681659545941 67 P61978,Q9Y4W6,P00846,P03915,Q9H173,Q9HA77,Q9BTV4,Q70HW3,O95831,Q99720,P09651,P23786,P35637,Q8NI60,O43676,P22626,P06753,P50402 18 +Abnormal oral physiology 0.5567157510930301 2.5388542172315054 0.0111216155401159 1.0 0.6254681659545941 52 Q96CV9,Q92796,Q9NR77,Q15165,P49959,P34897,Q15233,O15460,Q92804,P09651,P35637,Q14739,Q6UN15,P06753,P50995,P46100 16 +Hypothermia 0.8297956256621083 2.499719981751406 0.0124291505762306 1.0 0.6254681659545941 10 P00846,O43772 2 +Episodic vomiting 0.772170004426424 2.4717176747246494 0.0134465661801785 1.0 0.6254681659545941 12 P61978,P03915,Q9Y619,P00846,P22695 5 +Abnormality of salivation 0.595655008948247 2.470894793417534 0.013477546232091 1.0 0.6254681659545941 40 Q96CV9,Q92796,Q9NR77,Q15165,P49959,P34897,Q15233,Q92804,P09651,P35637,Q14739,P50995,P46100 13 +Xerostomia 0.7174372881143873 2.460557316324783 0.0138721412233258 1.0 0.6259866942077634 14 Q96CV9,Q15165,Q92804,P35637,Q14739,P50995 6 +Delayed cranial suture closure 0.6185398765098665 2.447151556952055 0.0143990277188776 1.0 0.6259866942077634 28 O75718,O75381,Q32P28,O75844,P36543 5 +Segmental peripheral demyelination remyelination 0.9556942784091952 2.4266584421249897 0.0152385947495803 1.0 0.6307179461215094 5 Q9NR77,P00846 2 +Fatigable weakness of bulbar muscles 0.7108232640425386 2.4257871323204765 0.0152752269591844 1.0 0.6307179461215094 14 Q96CV9,Q15165,Q92804,P35637,P06753,P50995 6 +Demyelinating peripheral neuropathy 0.6873845513574631 2.4192051123828637 0.015554466689899 1.0 0.6307179461215094 17 Q13217,P03915,P00846,Q9NR77,P41440 5 +Ectrodactyly 0.7030795297503937 2.384901338546856 0.0170837023112713 1.0 0.6504128284577543 14 Q9NR77,Q99720,Q9H3P2 3 +Dicarboxylic aciduria 0.6125259978561428 2.3812299482650485 0.0172549371666557 1.0 0.6504128284577543 24 P48735,O43772 2 +Abnormal circulating dicarboxylic acid concentration 0.5789097586382973 2.3679721207586413 0.0178858836177155 1.0 0.6504128284577543 41 P36551,P22695,P37268,P23786,P28288,Q14739,P41440,P55263,P48735 9 +Bowing of the legs 0.5648088587783509 2.3622950018894144 0.0181621831603713 1.0 0.6504128284577543 45 O75718,Q9NR77,Q13126,Q32P28,Q96HY6 5 +Lacticaciduria 0.9377832337570348 2.3582206846545346 0.0183627729003181 1.0 0.6504128284577543 5 Q9BQT8,P00846 2 +Foot dorsiflexor weakness 0.5941636633792851 2.309908304733877 0.0208932311989118 1.0 0.6791510964230028 31 Q9NR77,Q99720,Q9BQT8,Q14739 4 +Profound global developmental delay 0.6883220443658434 2.306455920262307 0.0210851704433692 1.0 0.6791510964230028 14 Q9GZY8,P46100,O75381,P37268 4 +Muscle stiffness 0.6224420784321667 2.306082062524414 0.0211060473935302 1.0 0.6791510964230028 22 P00846,Q9H173,Q15392,P23786,P53985 5 +Contractures of the joints of the upper limbs 0.4526347366750292 2.2993317492731835 0.0214861082768584 1.0 0.6791510964230028 66 Q9NR77,P37268,Q15392,Q99720,P23786,P35637,O75844,P42892,P98172 9 +Abnormality of femur morphology 0.4571165969739949 2.2799018399341393 0.0226135109206211 1.0 0.6791510964230028 65 O75718,Q9H173,O95831,Q32P28,Q96HY6,Q14739,O75844,P46100 8 +Abnormal femoral neck morphology 0.5774444358635226 2.2754153942413593 0.0228810227623694 1.0 0.6791510964230028 37 O75718,Q9H173,O95831,Q96HY6,O75844,P46100 6 +Intellectual disability progressive 0.7313495629065837 2.2727698640220497 0.023040051989871 1.0 0.6791510964230028 12 P46100,O95831 2 +Mitochondrial respiratory chain defects 0.9105706128825236 2.2532150910993103 0.024245590334007 1.0 0.6791510964230028 5 P00846,Q4J6C6 2 +Round face 0.6578048765108019 2.252644638768887 0.0242815641673552 1.0 0.6791510964230028 17 O75718 1 +Fatigable weakness of respiratory muscles 0.7025648750451692 2.24935283009585 0.0244900571269508 1.0 0.6791510964230028 13 Q96CV9,Q15165,Q92804,P35637,P50995 5 +Abnormal upper motor neuron morphology 0.8098820499559314 2.2341679974081523 0.0254720212804555 1.0 0.6895640046637612 8 Q99720 1 +Abnormal diaphysis morphology 0.474644184353511 2.217613316560223 0.0265812091384261 1.0 0.7054548036142394 61 Q9NX62,Q9Y619,O75718,P07237,Q9NR77,P48651,Q13126,Q32P28,Q96HY6,Q9NSE4,Q14739,P46100 12 +Wide cranial sutures 0.8196477421380832 2.210693048358495 0.0270571002553186 1.0 0.7054548036142394 7 O75718 1 +Talipes calcaneovalgus 0.8979858450680169 2.2042370843398316 0.0275076750099116 1.0 0.7054548036142394 5 Q9NR77,P46100 2 +Upper airway obstruction 0.8952362511339983 2.193501163577233 0.0282712908467785 1.0 0.7054548036142394 5 Q96HY6 1 +Hammertoe 0.6458478197092998 2.184452533839785 0.0289290115483737 1.0 0.7150496984891522 17 Q9NR77,Q99720,P39210 3 +Vertebral compression fracture 0.6501046870439797 2.1686140180046753 0.0301120000254129 1.0 0.722195414910141 16 Q32P28,O75718 2 +Rhizomelia 0.7559839489055556 2.165367264938617 0.0303595708670494 1.0 0.722195414910141 10 Q14739,Q15392,O75718 3 +Fatigable weakness of swallowing muscles 0.7088069553099653 2.160946398263186 0.0306994802089912 1.0 0.722195414910141 12 Q96CV9,Q15165,Q92804,P35637,P50995 5 +Wormian bones 0.6260098912689123 2.15912124859446 0.0308407615699533 1.0 0.722195414910141 19 Q32P28,O75718,O95831 3 +Ragged red muscle fibers 0.6480719914931176 2.1571774550703156 0.0309918403885791 1.0 0.722195414910141 16 P03915,P00846,O95831 3 +Abnormal neuron morphology 0.5760209682210414 2.1455975223135813 0.0319051032981385 1.0 0.722195414910141 26 Q15165,Q99720,P35637,Q92804 4 +Tinnitus 0.6524445483242797 2.1454101337474603 0.0319200695781196 1.0 0.722195414910141 15 Q9NR77,O95831,Q969G3 3 +Head tremor 0.6824558198534363 2.145253424834332 0.0319325901677216 1.0 0.722195414910141 13 Q99720,P35637 2 +Toe walking 0.6049311351880841 2.135649315168258 0.032708008567613 1.0 0.722195414910141 21 Q8TD16,O95831,Q99720,P35637,Q9BTV4,P50402 6 +Supranuclear gaze palsy 0.6496770407244735 2.130087375867626 0.0331644003688753 1.0 0.722195414910141 15 Q99720,P35637 2 +Toxemia of pregnancy 0.8395630882274732 2.1291913680045336 0.0332384307842308 1.0 0.722195414910141 6 O43772 1 +Disproportionate short limb short stature 0.6356372661506495 2.125831042938433 0.0335173302379365 1.0 0.722195414910141 17 Q14696,O75718,Q15392,Q32P28,Q14739,Q9UBM7 6 +Abnormal morphology of the musculature of the neck 0.7006591067557237 2.120188431325228 0.033990157638098 1.0 0.722195414910141 12 Q99720 1 +Abnormal circulating fatty acid concentration 0.6173031278179858 2.1069176431367427 0.0351247190001842 1.0 0.722195414910141 19 P56589,P23786,O43772,O75381 4 +Motor neuron atrophy 0.5986540201539099 2.096239837755261 0.0360609206396353 1.0 0.722195414910141 21 Q15165,Q99720,P35637,Q92804 4 +Postural instability 0.6226678566061282 2.092780134508064 0.0363687859530446 1.0 0.722195414910141 18 Q9NR77 1 +Abnormal circulating citrulline concentration 0.8647871801053881 2.0737821684211792 0.0380995459601061 1.0 0.722195414910141 5 P03915,P00846 2 +Dolichocephaly 0.5631403345769083 2.0536222584815103 0.0400122661172253 1.0 0.722195414910141 25 P61978,P56589,Q4J6C6,Q03164,O75381,Q9H3P2,P46100 7 +Bilateral sensorineural hearing impairment 0.561634312145453 2.0468762696702822 0.0406702346162863 1.0 0.722195414910141 26 Q13217,P03915,Q15067,P38159,Q96GW9,Q9NSE4,P35637 7 +Metaphyseal striations 0.8579047004629808 2.0465134049406757 0.040705884964181 1.0 0.722195414910141 5 Q13126 1 +Cough 0.5607854786934436 2.0410224616869455 0.0412485945199188 1.0 0.722195414910141 26 Q9NR77,P35610,O15460,P41440 4 +Abnormality of the pulmonary veins 0.8180097049047635 2.0404888349678414 0.0413016619538662 1.0 0.722195414910141 6 O75718 1 +Multiple prenatal fractures 0.7776343904990699 2.0306916012332645 0.0422862888706336 1.0 0.722195414910141 7 Q32P28,Q14696,Q14739,O75718 4 +Abnormal circulating bilirubin concentration 0.558827475573848 2.0275072494864497 0.0426105638117084 1.0 0.722195414910141 26 P36551,P23786,P28288,Q14739,P41440,P55263 6 +Abnormal epiphyseal ossification 0.6300758462158167 2.020863325230743 0.0432939153165348 1.0 0.722195414910141 15 Q96HY6,O75381,Q14739,Q9UBM7 4 +Spondyloepimetaphyseal dysplasia 0.8493594112821166 2.012551316968139 0.0441618528916674 1.0 0.722195414910141 5 O95831 1 +Inverted nipples 0.7445990243637566 2.011346816169231 0.0442888367265155 1.0 0.722195414910141 9 P61978,P56589,Q15067,Q96AA3 4 +Aplasia hypoplasia of the femur 0.6790456164646853 2.0112074937235462 0.0443035445822184 1.0 0.722195414910141 12 O95831 1 +Abnormal circulating non proteinogenic amino acid concentration 0.7696983448486185 1.9962900511878192 0.0459023603322641 1.0 0.7274004696555306 7 P03915,P00846 2 +Cutaneous photosensitivity 0.564117242413136 1.9915976249538905 0.0464152241826918 1.0 0.7310970140245997 23 P50336,Q06136,P36551,P22830,P37268,Q9UBM7,Q15126 7 +Abnormal circulating long chain fatty acid concentration 0.843776866066958 1.990301916231546 0.0465576870606976 1.0 0.7310970140245997 5 P23786,O75381 2 +Shawl scrotum 0.8055630177530702 1.9888856929807697 0.0467138212875348 1.0 0.7310970140245997 6 P46100,Q9Y619,P98172 3 +Tremor by anatomical site 0.5519597143806272 1.9768434151967225 0.0480593325324809 1.0 0.7434484501963381 25 Q9Y4W6,Q9NR77,Q99720,P35637,Q96KR1 5 +Muscle fiber atrophy 0.5943436556649884 1.9679449682528936 0.0490743699946252 1.0 0.7565770669001882 19 P61978,Q9BTV4,Q99720,P23786,P35637,P22626,P50402 7 +Abnormal femoral neck head morphology 0.5157218597931754 1.9657261843447809 0.049330248483582 1.0 0.7579526017004428 45 O75718,Q9H173,O95831,Q96HY6,Q14739,O75844,P46100 7 +Neurogenic bladder 0.799030308176079 1.961692231566596 0.0497983268210699 1.0 0.7625683177852738 6 P50336,P56589 2 +Sensorimotor neuropathy 0.5430048536091698 1.9556388830791311 0.0505077090293648 1.0 0.7672955985829032 32 Q13217,Q9Y4W6,P00846,P03915,Q9NR77,O95831,P41440,P39210 8 +Head titubation 0.7972710167570388 1.954356166538854 0.0506591107317053 1.0 0.7672955985829032 6 Q99720 1 +Abnormal larynx physiology 0.6459549761515574 1.9533184156450096 0.050781876687215 1.0 0.7672955985829032 13 Q96CV9,Q15165,Q92804,P35637,P50995 5 +Abnormal circulating lipid concentration 0.4279436683476313 1.9352239063449357 0.0529628253291432 1.0 0.7686352438138014 73 P56589,P34913,Q9BTV4,Q9Y4I1,O43772,P37268,O75381,P28070,P22830,Q15392,P23786,Q9UBM7,Q14739,Q8N511,O75844,P50402 16 +Abnormal circulating acetylcarnitine concentration 0.7553919390311039 1.933959256336212 0.0531181375201446 1.0 0.7686352438138014 7 P23786,O43772 2 +Micromelia 0.5730569339051511 1.9339536109516389 0.0531188316843254 1.0 0.7686352438138014 21 O75718,Q15392,Q96HY6,Q14739,P48735 5 +Abnormality of krebs cycle metabolism 0.7915154709891081 1.9303186744754492 0.0535673645820042 1.0 0.7686352438138014 6 P00846 1 +Agitation 0.5374531085040117 1.9250463708412924 0.054223557289474 1.0 0.7686352438138014 33 P35610,Q15165,Q92804,P35637,P42892 5 +Neck muscle weakness 0.6404938167057408 1.92427971195562 0.0543195321959282 1.0 0.7686352438138014 13 Q99720,P35637,Q9BTV4 3 +Retinal telangiectasia 0.7893840885700656 1.9214026816903271 0.0546809607290803 1.0 0.7686352438138014 6 P00846 1 +Abnormal csf protein level 0.6819853411306643 1.921078748446556 0.0547217803623527 1.0 0.7686352438138014 11 Q9NR77,P03915 2 +Abnormal peripheral myelination 0.540247756416019 1.9189247517756631 0.0549938576355666 1.0 0.7686352438138014 30 Q9NR77,P03915,P00846 3 +Barrel shaped chest 0.903902083512583 1.9153310570194704 0.0554502972986061 1.0 0.7686352438138014 4 Q32P28 1 +Macrovesicular hepatic steatosis 0.7506500098376768 1.9132111995761585 0.0557210203348013 1.0 0.7686352438138014 7 P23786 1 +Ulnar claw 0.824276371592036 1.9122023677678908 0.0558502425414786 1.0 0.7686352438138014 5 Q9NR77 1 +Psychosis 0.5609600615162441 1.910748056343248 0.0560369658631541 1.0 0.7686352438138014 22 P50336,Q5JRX3,P03915,P36551,O15118,Q6DKK2,Q8WVX9 7 +Anarthria 0.7495937587513303 1.9085837133928512 0.0563158145727729 1.0 0.7686352438138014 7 Q99720 1 +Limb dystonia 0.6587173101032663 1.9075854446506253 0.0564448178614305 1.0 0.7686352438138014 12 Q99720,P35637 2 +Abnormal circulating porphyrin concentration 0.901377604393813 1.905738802774811 0.0566841022754256 1.0 0.7688541528520862 4 P50336,P22830 2 +Severe muscular hypotonia 0.5382866807743536 1.9048321758421445 0.0568018899204707 1.0 0.7688541528520862 30 P56589,Q8TD16,Q9HA77,O75381,O95831,Q00577,Q9NWM8,Q9GZY8,Q01105 9 +Premature graying of hair 0.7343833871330911 1.9019154068753068 0.0571822146528537 1.0 0.771705377570264 8 Q13126 1 +Ketoacidosis 0.7194481379675917 1.896832682094698 0.0578500244143023 1.0 0.7738291501066086 9 P53985 1 +Impaired pain sensation 0.5819867389045551 1.8923817715767908 0.0584401329494568 1.0 0.7794302775780928 19 Q9NR77,P39210,O95831 3 +Abnormal astrocyte morphology 0.6104486760029593 1.881214042988488 0.0599428082033668 1.0 0.7814968308172898 14 P48735,P00846,O95831 3 +Abnormal delivery 0.5633073492364664 1.8714927213918129 0.0612768178002209 1.0 0.7814968308172898 21 Q9Y619,O75718,Q9UBM7,Q96EY7,O75844 5 +Proximal muscle weakness 0.4187915849004391 1.8672606885462464 0.0618651922774038 1.0 0.7844060661813456 65 P50336,P00846,P36551,Q8TD16,Q9BQT8,Q13126,Q99720,P17252,P35637,Q8NI60,Q8NAT1,P50402 12 +Limb muscle weakness 0.4289699684439206 1.8668845118838175 0.0619177171853788 1.0 0.7844060661813456 79 P50336,P00846,P36551,Q9NR77,Q9BQT8,Q13126,Q15067,Q99720,Q14739,P39210,P50402,Q969G3 12 +Increased bone mineral density 0.5356343420713512 1.8623630300132072 0.0625519365655897 1.0 0.7902394652786174 24 P48651,Q13126,Q15392,P54802,Q14739 5 +Abnormal urine ph 0.5080454748609915 1.8561453527250888 0.0634328428273112 1.0 0.7968442196463171 43 P50336,P00846,P03915,Q9BQT8,O43772,P48735 6 +Action tremor 0.4787139720648684 1.8560582614764023 0.0634452541365637 1.0 0.7968442196463171 52 Q5JRX3,Q9Y4W6,P00846,P03915,Q9NR77,Q15233,Q99720,P35637,P41440 9 +Recurrent fractures 0.5312856671640277 1.8481491878437637 0.06458076373961 1.0 0.8048865354282898 29 O75718,Q13126,Q32P28,P52788,P48735 5 +Generalized muscle weakness 0.5303438934010778 1.8413949376524652 0.065563704129516 1.0 0.8048865354282898 29 Q15165,P35637,O95831,Q92804 4 +Decreased calvarial ossification 0.8840115845908785 1.8395451296640624 0.0658350464334485 1.0 0.8048865354282898 4 O75718 1 +Disproportionate short stature 0.5578774447822252 1.836556820022369 0.0662753467398098 1.0 0.8080972572993435 21 O75718,Q15392,Q32P28,Q96HY6,Q14739 5 +Axonal degeneration 0.7688120694632192 1.8349511725928005 0.0665129244739577 1.0 0.8084204046309309 6 Q9BQT8 1 +Abnormality of tibia morphology 0.6433170678326323 1.828385086102685 0.0674917780634127 1.0 0.8141978955766612 12 O95831 1 +Osteoarthritis 0.6404576902854329 1.813615679358512 0.0697369148077324 1.0 0.8324501011694679 12 Q96HY6 1 +Blurred vision 0.7982031858422813 1.8068880906024831 0.070779729815174 1.0 0.838297424998467 5 P03915,P00846 2 +Titubation 0.6980866968310677 1.7985341433526685 0.0720924029976906 1.0 0.8450418784368475 9 Q99720,P35637 2 +Thin ribs 0.6167981860195888 1.797355660347646 0.0722791750950544 1.0 0.8450531833735414 13 Q32P28,O75844,O95831 3 +Sensory ataxia 0.8722194680798001 1.7943969602350796 0.0727498317688031 1.0 0.8483749612423502 4 Q9NR77,P54802 2 +Abnormal corpus striatum morphology 0.583769087804217 1.7885180682446564 0.0736924632407385 1.0 0.8532299578783115 16 O95831 1 +Brisk reflexes 0.5338903467450845 1.7882916027876743 0.0737289739327564 1.0 0.8532299578783115 23 Q5U5X0,Q10713,Q99720,P35637,Q8NI60 5 +Abnormal pericardium morphology 0.6517035774501931 1.7708355748672024 0.0765880482381677 1.0 0.8751821500701656 11 P14174 1 +Abnormal lower motor neuron morphology 0.7049442287058945 1.7692082638055568 0.0768591256307056 1.0 0.8751821500701656 8 Q99720 1 +Postural tremor 0.5663619945686035 1.7554697781974409 0.0791789856765636 1.0 0.8913515516262662 18 Q9NR77,P03915,P00846 3 +Soft skin 0.7002644372905568 1.7479604653185885 0.0804708734526493 1.0 0.8970135599574738 8 Q13126 1 +Hyperconvex nail 0.7128025809005816 1.7460940630044584 0.0807946082891781 1.0 0.8984202408292966 7 P42892,Q9Y619 2 +Hepatic failure 0.4722594244507461 1.7335726200389208 0.0829939420378489 1.0 0.9097012680850552 50 P00846,Q9Y619,P03915,O15118,Q10713,P22830,O43772,O75381,O15460,P23786,P28288,P39210,P46100 13 +Peripheral axonal degeneration 0.4008116754448231 1.7288834994720848 0.0838299478045896 1.0 0.9097012680850552 66 Q9Y4W6,P00846,P03915,Q9BQT8,Q15067,O95831,P41440,Q6DKK2,P39210 9 +Central hypoventilation 0.7087861285138906 1.7282070065640402 0.0839511180209271 1.0 0.9097012680850552 7 O75306,Q8N183,P06753 3 +Slowly progressive 0.4526597845329962 1.7249077048960513 0.0845441068162045 1.0 0.9097012680850552 55 Q9NR77,Q99720,O95831 3 +Hypoketotic hypoglycemia 0.7078949710195879 1.7242344978198794 0.0846655187185645 1.0 0.9097012680850552 7 P23786,O43772 2 +Muscle spasm 0.4440516274393318 1.722346388716624 0.0850067891089589 1.0 0.9097012680850552 57 P00846,Q9NR77,Q15165,Q92804,P23786,P35637,P53985 7 +Paresthesia 0.5234334992549577 1.7171471793153668 0.0859522837369157 1.0 0.9097012680850552 23 Q9NR77,O15460 2 +Slow decrease in visual acuity 0.6803134419535467 1.7160562918103506 0.0861517399748061 1.0 0.9097012680850552 9 P03915,P00846 2 +Recurrent fever 0.5654150700412205 1.713384013418758 0.0866419154018847 1.0 0.9097012680850552 17 Q9NR77,Q9Y2V7,P28070 3 +Ankylosis 0.773481838908674 1.7061513589651618 0.0879799023169765 1.0 0.9097012680850552 5 O75844 1 +Abnormal circulating fatty acid anion concentration 0.5979592618910096 1.6954255792109811 0.0899947169103347 1.0 0.9097012680850552 13 O43772 1 +Excessive salivation 0.5112089889108398 1.6938144672327 0.0903005441075792 1.0 0.9097012680850552 26 Q92796,Q9NR77,P49959,P34897,Q15233,P46100 6 +Sparse lateral eyebrow 0.7352028294441648 1.6922461259787989 0.0905990551304429 1.0 0.9097012680850552 6 P61978,Q00577,Q9Y2V7 3 +Distal lower limb muscle weakness 0.5493291163405523 1.6902626648289458 0.0909777144434005 1.0 0.9097012680850552 19 Q9NR77 1 +Weight loss 0.4003971178832175 1.682788771075051 0.092415989555683 1.0 0.9097012680850552 69 Q06136,P35610,O15460,Q99720,P35637,O75844,P42892,P46100 8 +Aplasia hypoplasia involving the skeletal musculature 0.6338490792937866 1.681292752648961 0.092706064909803 1.0 0.9097012680850552 11 Q9NR77,Q8NAT1,Q9H173 3 +Abnormal synaptic transmission at the neuromuscular junction 0.5089086726028405 1.677468447781113 0.0934509143857778 1.0 0.9097012680850552 26 Q96CV9,Q15165,Q92804,P35637,P06753,P50995 6 +Distal upper limb amyotrophy 0.5942500656275751 1.6752568288314862 0.093883851831944 1.0 0.9097012680850552 13 Q9NR77 1 +Fibrous tissue neoplasm 0.5465236250549383 1.6727471483619405 0.0943770832701011 1.0 0.9097012680850552 19 Q13126,Q15392 2 +Slender long bone 0.6133206752327885 1.6724963551713816 0.0944264859932593 1.0 0.9097012680850552 12 Q32P28,P37268 2 +Abnormal rib cage morphology 0.4030349387027621 1.671506631929529 0.0946216498650454 1.0 0.9097012680850552 72 Q14696,O75718,P07237,O95831,Q9UBM7,P98172,Q32P28,Q96HY6,P54802,Q14739,P25054,O75844,Q9H3P2,Q8TAA9,Q9Y619,P48651,Q03164,P00813,P17252 19 +Hypoventilation 0.6130299625968373 1.6709756732251977 0.0947264829503966 1.0 0.9097012680850552 12 P61978,O75306,Q8N183,Q00577,P06753 5 +Fluctuations in consciousness 0.6953533646110338 1.6681852592231454 0.0952789561984024 1.0 0.9097012680850552 7 P00403,P03915 2 +Polyneuropathy 0.5455272493425007 1.666521087489173 0.0956096716596486 1.0 0.9097012680850552 19 P00846,O95831 2 +Wide anterior fontanel 0.5233331964705568 1.6615897410136329 0.0965950617342015 1.0 0.9135968618532044 22 Q32P28,O75381,O75718 3 +Abnormality of neutrophil morphology 0.7260031071457022 1.652889043945042 0.0983534473060001 1.0 0.915357563214558 6 P41440 1 +Progressive muscle weakness 0.5894864852931936 1.649309098384529 0.0990843266356649 1.0 0.915357563214558 13 Q9Y606,P56589,O75381,Q9H173 4 +Abnormal speech prosody 0.6781795325276243 1.6471585759813496 0.0995254557712188 1.0 0.915357563214558 8 P00846 1 +Pericarditis 0.7556695635789582 1.6330811045170317 0.102451940079606 1.0 0.915357563214558 5 P14174 1 +Myoclonic spasms 0.7205318159175185 1.6294265795494498 0.1032227458471053 1.0 0.915357563214558 6 P00846,Q969G3 2 +Stuttering 0.8285551785030609 1.6259425720761578 0.1039618725997426 1.0 0.915357563214558 4 P03915,Q12873 2 +Cyanosis 0.5437781012751963 1.6174172286582198 0.1057882492644719 1.0 0.915357563214558 18 O43772 1 +Hyperventilation 0.6714439968758386 1.616250061305863 0.106040259132885 1.0 0.915357563214558 8 P03915,P00846 2 +Aplasia hypoplasia of the clavicles 0.6025274829212196 1.615920263981605 0.1061115537854178 1.0 0.915357563214558 12 O75844,Q9Y619,P98172 3 +Abnormality of fontanelles 0.4700433785562398 1.607549693074053 0.1079338376447032 1.0 0.915357563214558 46 P56589,Q9Y619,O75718,O75381,Q32P28,O75844,P46100,P36543 8 +Sclerocornea 0.669531566569584 1.607460774902486 0.107953327393711 1.0 0.915357563214558 8 P49454,Q9H3P2,Q9UBM7 3 +Impaired vibration sensation in the lower limbs 0.5619299605773737 1.6073903050870006 0.1079687754730867 1.0 0.915357563214558 14 Q9NR77 1 +Impaired tactile sensation 0.6682770133254032 1.6016918533815845 0.1092237675352323 1.0 0.915357563214558 8 Q9NR77 1 +Abnormal motor nerve conduction velocity 0.5283824111602076 1.599700884402294 0.1096649555827502 1.0 0.915357563214558 20 Q9NR77 1 +Anterior rib cupping 0.7460820656654419 1.593596869983004 0.1110263560023998 1.0 0.915357563214558 5 O95831 1 +Tongue fasciculations 0.6157564352529036 1.5898951362907747 0.1118584441718497 1.0 0.915357563214558 11 O95831 1 +Breech presentation 0.6531235787972139 1.588757401252708 0.1121151740544519 1.0 0.915357563214558 9 Q9Y619,O75718 2 +Low plasma citrulline 0.9676998368678612 1.58845311141903 0.1121839157522854 1.0 0.915357563214558 2 P00846 1 +Vascular tortuosity 0.9676998368678612 1.58845311141903 0.1121839157522854 1.0 0.915357563214558 2 P00846 1 +Multiple glomerular cysts 0.9676998368678612 1.58845311141903 0.1121839157522854 1.0 0.915357563214558 2 P00846 1 +Retinal arterial tortuosity 0.9676998368678612 1.58845311141903 0.1121839157522854 1.0 0.915357563214558 2 P00846 1 +Leber optic atrophy 0.9676998368678612 1.58845311141903 0.1121839157522854 1.0 0.915357563214558 2 P00846 1 +Pseudoarthrosis 0.7435174240991103 1.5830178065263067 0.1134174058828278 1.0 0.915357563214558 5 O75844 1 +Decreased plasma carnitine 0.6139533472228275 1.580752720888527 0.1139345886470293 1.0 0.915357563214558 11 O43772 1 +Broad palm 0.7427937411183608 1.580031374896694 0.1140996815010408 1.0 0.915357563214558 5 O95831 1 +Sensory axonal neuropathy 0.595645124612734 1.5797220408636856 0.1141705357654272 1.0 0.915357563214558 12 P34897,Q15067,P22626,O95831 4 +Abnormal enchondral ossification 0.4948250824235751 1.5769818822131048 0.1147996939783881 1.0 0.915357563214558 24 Q9Y619,O75381,Q96HY6,Q14739,Q9UBM7 5 +Abnormal erythrocyte sedimentation rate 0.6622288172281281 1.5738455114429677 0.1155231694922025 1.0 0.915357563214558 8 P28070,P14174 2 +Calcinosis 0.7410808729442575 1.572960675525854 0.1157279241091404 1.0 0.915357563214558 5 O75844 1 +Brushfield spots 0.8117415252298816 1.5606097442278974 0.1186158582494605 1.0 0.9166830628302618 4 O75381 1 +Bloody diarrhea 0.7040671126273859 1.558584698975603 0.119094706849026 1.0 0.9166830628302618 6 P46100,P25054 2 +Short ribs 0.6580406762232976 1.5545304648527871 0.1200579356209903 1.0 0.9166830628302618 8 Q96HY6,Q14739 2 +Calvarial skull defect 0.7024238840200301 1.5514959973825129 0.1207828658151324 1.0 0.9166830628302618 6 Q14739 1 +Impaired visuospatial constructive cognition 0.644986182581812 1.5504177166360282 0.1210412889449512 1.0 0.9166830628302618 9 Q10713,P00403,P03915 3 +Macrogyria 0.6685583910517778 1.5475996789587638 0.1217187087657514 1.0 0.9166830628302618 7 O14936,Q15392 2 +Genu varum 0.6442113122140358 1.5467615141230866 0.1219207636917696 1.0 0.9166830628302618 9 Q96HY6 1 +Microcytic anemia 0.6246276945778646 1.5394457884257522 0.1236955029659403 1.0 0.9166830628302618 10 Q9BQT8,P46100 2 +Thoracic kyphoscoliosis 0.6994162913721249 1.5385133707107863 0.1239231418496715 1.0 0.9166830628302618 6 O75844 1 +Abnormal bronchus physiology 0.699333521343695 1.53815593599263 0.1240104919897899 1.0 0.9166830628302618 6 P46100 1 +Bronchospasm 0.699333521343695 1.53815593599263 0.1240104919897899 1.0 0.9166830628302618 6 P46100 1 +Stillbirth 0.6055419544570313 1.5380277607363355 0.1240418272472032 1.0 0.9166830628302618 11 O75844,Q14739 2 +Hyporeflexia of upper limbs 0.95464926590538 1.5367239775755432 0.124360916835152 1.0 0.9166830628302618 2 Q9NR77 1 +Aplasia hypoplasia of the lungs 0.4883643483950139 1.5338416288596015 0.1250686189343772 1.0 0.917540075351334 28 Q8TAA9,Q7Z4L5,Q14739,Q9UBM7,O75844,Q9H3P2,Q5JTZ9,P98175 8 +Abnormal visual field test 0.7314624766692596 1.5332009459133955 0.1252263512847911 1.0 0.917540075351334 5 P00846 1 +Thickened nuchal skin fold 0.6040377432700068 1.5303745438472385 0.1259240463059807 1.0 0.9182769642419846 11 P61978,O75381,P98172 3 +Melena 0.8035491627574518 1.528698949209437 0.1263390929310417 1.0 0.9182769642419846 4 P46100 1 +Mitochondrial inheritance 0.8025390948053528 1.5247613467462062 0.1273186341714112 1.0 0.9182769642419846 4 P00846 1 +Decreased number of peripheral myelinated nerve fibers 0.5434137789938671 1.52449835367202 0.1273842678041683 1.0 0.9182769642419846 15 Q9NR77 1 +Cupped ribs 0.6956767814278944 1.5223568790154096 0.1279196832668019 1.0 0.9182769642419846 6 O95831 1 +Abnormal circulating sulfur amino acid concentration 0.6504546797662616 1.519480170945073 0.1286416755195591 1.0 0.9182769642419846 8 P41440 1 +Upper limb amyotrophy 0.5380112135712064 1.5189208647184926 0.1287824164309592 1.0 0.9182769642419846 16 Q9NR77 1 +Hypoglycemic seizures 0.6947330865340909 1.5182771869886595 0.1289445361956942 1.0 0.9182769642419846 6 P53985,Q16836 2 +Aplasia hypoplasia of the tongue 0.8007594603119064 1.5178220727253604 0.1290592591162687 1.0 0.9182769642419846 4 Q9UBM7,P48651 2 +Microglossia 0.8007594603119064 1.5178220727253604 0.1290592591162687 1.0 0.9182769642419846 4 Q9UBM7,P48651 2 +Postaxial polydactyly 0.5275139231247253 1.517180838415753 0.1292210327869107 1.0 0.9182769642419846 18 P61978,O00459,Q10713,P17252,Q14739,Q9UBM7,Q9Y2V7,P98175 8 +Optic disc hypoplasia 0.7260008606429292 1.5105846786930524 0.1308942999586888 1.0 0.9234345937772932 5 P25054,O95721 2 +Muscle fibrillation 0.5409849462416637 1.510319061706273 0.1309620301201306 1.0 0.9234345937772932 15 O95831 1 +Centrocecal scotoma 0.7957593992212466 1.4983147648292374 0.1340514897591735 1.0 0.932057661507546 4 P00846 1 +Ureteral duplication 0.6898726194048082 1.4972495708900428 0.1343283312643786 1.0 0.932057661507546 6 O75844,P23786 2 +Scotoma 0.5424881389448744 1.496105268457398 0.1346262252192187 1.0 0.932057661507546 14 Q9H061,P03915,P00846 3 +Abnormal nerve conduction velocity 0.4663487977262506 1.4960362321084852 0.1346442136346652 1.0 0.932057661507546 42 Q9NR77,O95831 2 +Iron deficiency anemia 0.6559153373415578 1.4903458387699229 0.1361333256001704 1.0 0.9355664643765808 7 P46100,P28288 2 +Widely spaced incisors 0.720660520362037 1.4884448885653765 0.1366336059815096 1.0 0.9355664643765808 5 P46100,Q8WVM7 2 +Upper limb spasticity 0.6554162357211768 1.4880814514875331 0.136729414461965 1.0 0.9355664643765808 7 Q99720 1 +Central scotoma 0.5955352471869055 1.4870467011182604 0.1370024769733515 1.0 0.9355664643765808 11 P03915,P00846 2 +Nemaline bodies 0.7918521605051467 1.483060575090768 0.1380583174712093 1.0 0.939709901905561 4 O43676 1 +Pancreatic islet cell hyperplasia 0.9409461663947774 1.4823941564321117 0.1382354479339309 1.0 0.939709901905561 2 P53985 1 +Metaphyseal cupping 0.9409461663947756 1.482394156432104 0.1382354479339329 1.0 0.939709901905561 2 O95831 1 +Perseveration 0.7182714478976028 1.4785325504357576 0.139265291255398 1.0 0.9437234980923068 5 P35637 1 +Portal fibrosis 0.7903253742892878 1.477097523125732 0.1396494974089979 1.0 0.9437234980923068 4 P55263 1 +Adenomatous colonic polyposis 0.7170757727131774 1.473569912892881 0.1405974271631249 1.0 0.9485808289527754 5 P20585,P78549 2 +Hypoplasia of the frontal lobes 0.6823912990928563 1.4648356868594483 0.1429657528181369 1.0 0.954784498996897 6 Q86XL3,Q9UBM7 2 +Adducted thumb 0.4936129875626415 1.4616118613836342 0.143847602139751 1.0 0.9570386599114648 22 Q86XL3,P42892 2 +Increased muscle lipid content 0.637898582511195 1.461294734825265 0.1439345741819353 1.0 0.9570386599114648 8 Q9Y4W6,P23786,Q8NI60 3 +Neurodegeneration 0.4773285188007868 1.4518962220486098 0.1465304631907735 1.0 0.96328254534742 27 Q6DKK2,Q15165,P35637,Q92804 4 +Dyspnea 0.4064953176448882 1.4505468974283615 0.1469060712441576 1.0 0.96328254534742 92 P00846,P03915,Q8TCJ2,Q9Y619,Q15165,O95831,Q92804,P23786,P35637,O75844,P50995,P46100 12 +Abnormality of the wrist 0.4763716017316699 1.444440300595291 0.1486151613454502 1.0 0.96328254534742 26 O95831 1 +Enlarged thorax 0.5206791591805301 1.443362713679572 0.1489183218555805 1.0 0.96328254534742 17 Q32P28,O75844,Q14739 3 +Dental crowding 0.4903915568799133 1.43980318494034 0.1499230898626788 1.0 0.96328254534742 22 Q01105,Q15233,P52788,Q9UBM7,O75844,P36543 6 +Aplasia hypoplasia involving the vertebral column 0.5288464307510078 1.4392953980413816 0.150066846154353 1.0 0.96328254534742 15 Q96HY6,O95831 2 +Axial dystonia 0.950621928494736 1.4386013796825157 0.1502634952401123 1.0 0.96328254534742 3 Q99720 1 +Misalignment of incisors 0.6761447594197706 1.4377304446126695 0.1505105513590718 1.0 0.96328254534742 6 P46100,Q8WVM7 2 +Horizontal nystagmus 0.4751108077014446 1.437178254710573 0.1506673501143915 1.0 0.96328254534742 24 P00846,Q9H061,O14773,O95831,Q96GW9 5 +Absence of subcutaneous fat 0.6440834334313175 1.4365860735836162 0.1508356430342736 1.0 0.96328254534742 7 O75844 1 +Extramedullary hematopoiesis 0.7795446366967873 1.434958035944037 0.1512990560663722 1.0 0.96328254534742 4 Q14739 1 +Oromandibular dystonia 0.7781765707909527 1.429606710567016 0.1528299284645571 1.0 0.96328254534742 4 Q99720 1 +Prenatal maternal abnormality 0.5490766599642938 1.4273703708443972 0.1534731665088999 1.0 0.96328254534742 13 O43772 1 +Carcinoid tumor 0.7774915026200147 1.4269267040459042 0.1536010226851005 1.0 0.96328254534742 4 P46100 1 +Abnormal cardiac ventricular function 0.5225272638123927 1.4266420880154125 0.15368308614137 1.0 0.96328254534742 16 O75844,P03915,P46100 3 +Diastema 0.6187582247575054 1.4261917384879264 0.1538130036967526 1.0 0.96328254534742 9 P17252,P46100,Q8WVM7 3 +Submucous cleft of soft and hard palate 0.4807875731257931 1.4233936368628228 0.1546220760570138 1.0 0.96328254534742 23 O75844,Q15392,Q9Y619,P48651 4 +Abnormal clavicle morphology 0.5009316536987815 1.422698587561961 0.1548235502560671 1.0 0.96328254534742 20 Q9Y619,O75844,P98172,Q14739 4 +Pulmonary hypoplasia 0.4876673641297772 1.4213441878408926 0.155216723341875 1.0 0.96328254534742 22 Q8TAA9,Q14739,Q9UBM7,O75844,Q5JTZ9,P98175 6 +Abnormality of the ribs 0.4051096698920124 1.41844955310946 0.1560595570280902 1.0 0.96328254534742 59 P25054,Q8TAA9,Q9Y619,O75718,P07237,P48651,Q03164,P00813,O95831,Q32P28,Q96HY6,P54802,Q9UBM7,Q14739,O75844,Q9H3P2 16 +Mixed demyelinating and axonal polyneuropathy 0.7034093569126614 1.416771728238941 0.1565496780357858 1.0 0.96328254534742 5 P00403,P03915 2 +Skin erosion 0.6385450688633872 1.4113686283700824 0.1581359482245592 1.0 0.96328254534742 7 O75844 1 +Elevated hepatic transaminase 0.408311035054776 1.409339866642222 0.158734695839245 1.0 0.96328254534742 97 P50336,Q9Y619,P22695,P28070,O43772,Q15067,P23786,P28288,Q8N511,Q14739,P55263,Q9Y2V7,P39210,P46100,Q16625 15 +Hip pain 0.7011853269052912 1.4075165853079057 0.159274262769846 1.0 0.96328254534742 5 P22626,O75844 2 +Poikilocytosis 0.5453634198437303 1.4068399093772903 0.1594748653685291 1.0 0.96328254534742 13 P41440 1 +Arm dystonia 0.9403907386999208 1.401830656895456 0.1609658214338751 1.0 0.9670707475313928 3 Q99720 1 +Widely patent fontanelles and sutures 0.7700038532358182 1.3976230871223423 0.1622262816772695 1.0 0.9710901403290942 4 O75844 1 +Acute phase response 0.4696374967899236 1.3965814129760554 0.1625394828773418 1.0 0.9710901403290942 25 O15460,P28070,P14174,P41440 4 +Absence of pubertal development 0.6664914024210732 1.395776109296024 0.1627819268286505 1.0 0.9710901403290942 6 O75844 1 +Neck flexor weakness 0.9383234593286888 1.394401259153213 0.1631964680925197 1.0 0.9710901403290942 3 Q99720 1 +Severe short stature 0.4945130262943325 1.381092136595414 0.1672506330547272 1.0 0.9710901403290942 20 Q9Y619,P48651,Q9H173,Q15392,Q96HY6 5 +Limb girdle muscle atrophy 0.5224409835199165 1.3806561424257515 0.1673847122762803 1.0 0.9710901403290942 14 O14979,Q9Y6X9,Q14331,P09651,Q9BTV4,P06753,P50402 7 +Dystrophic toenail 0.6627115427065311 1.3793289464592031 0.167793355598264 1.0 0.9710901403290942 6 O75844 1 +Male reproductive system neoplasm 0.5568877718958605 1.3743795033633652 0.169323895955415 1.0 0.9710901403290942 12 Q13423,Q92878,P49959,Q8IY37,P25054 5 +Symptomatic seizures 0.6269926089452521 1.3586726475203903 0.1742503432626598 1.0 0.9728763789576228 7 P53985,Q16836 2 +Elevated urinary carboxylic acid 0.6572484818621036 1.355540629586354 0.1752453729371839 1.0 0.9728763789576228 6 P50336 1 +Respiratory arrest 0.6565247130591824 1.3523876542985906 0.1762513367367457 1.0 0.9728763789576228 6 O43772 1 +Frontotemporal dementia 0.6143704677895583 1.3517757683179208 0.176447058121643 1.0 0.9728763789576228 8 O96008,P09651,P35637,P22626,Q14203 5 +Morphological abnormality of the pyramidal tract 0.4769030097708118 1.3482756525022843 0.1775697400659641 1.0 0.9728763789576228 22 P00846,P35637,O95831 3 +Ventricular hypertrophy 0.4611152795626658 1.3469371724293662 0.1780004682217342 1.0 0.9728763789576228 32 P03915,O43772,Q15233,P23786,O75844 5 +Skin rash 0.494843376174761 1.3466919896816785 0.1780794532037195 1.0 0.9728763789576228 19 Q06136,P28070,P14174 3 +Abnormal renal tubule morphology 0.4765805507879513 1.346084007803921 0.1782754255215106 1.0 0.9728763789576228 22 P03915,P00846 2 +Abnormality of thalamus morphology 0.5043397210934921 1.343770183742261 0.1790227139706677 1.0 0.9728763789576228 17 P11166,Q9UPT5,Q96KP1,Q96EY7,Q9GZY8,Q969G3 6 +Lower limb pain 0.6541315060775789 1.341959893679906 0.1796090000543229 1.0 0.9728763789576228 6 P00846,Q8WVX9 2 +High frequency sensorineural hearing impairment 0.7538176414270432 1.334222031541413 0.1821311012130881 1.0 0.9728763789576228 4 O75844 1 +Chondrosarcoma 0.919418445285371 1.3264870232119574 0.1846784306815492 1.0 0.9728763789576228 3 Q92804 1 +Abnormality of peripheral nerves 0.4365640202901855 1.3204461092524735 0.1866861175194611 1.0 0.9728763789576228 46 Q9NR77,Q99720,Q9Y619,O95831 4 +Dermatological manifestations of systemic disorders 0.3651569738408184 1.3104373002875158 0.1900479421062679 1.0 0.9728763789576228 67 P36551,O14936,O15118,O43772,O75381,P28288,Q14739,O75844,P39210,P46100,Q16625 11 +Gaze evoked nystagmus 0.5933606952715692 1.3051466189300664 0.1918429270061805 1.0 0.9728763789576228 9 Q10713,P41440 2 +Psychotic mentation 0.7458167868274905 1.3028682675537016 0.1926197390899546 1.0 0.9728763789576228 4 P03915 1 +Broad columella 0.7455030479798159 1.3016387368766866 0.1930399111992273 1.0 0.9728763789576228 4 P36543 1 +Thoracic hypoplasia 0.4560591073104673 1.3012377357056286 0.1931770923414117 1.0 0.9728763789576228 30 Q14696,O75718,Q92796,Q9UM00,Q96HY6,Q14739 6 +Reduced subcutaneous adipose tissue 0.5917735006695313 1.2975642784630494 0.1944371037715009 1.0 0.9728763789576228 9 O75844 1 +Aplasia hypoplasia of the cerebral white matter 0.5913483433738435 1.295532946070601 0.195136443622556 1.0 0.9728763789576228 9 P11166,P00403,P03915 3 +Aplastic clavicle 0.893637846655788 1.2951465762300785 0.1952696701842013 1.0 0.9728763789576228 2 Q9Y619 1 +Lacrimal duct stenosis 0.893637846655787 1.2951465762300738 0.1952696701842029 1.0 0.9728763789576228 2 Q13428 1 +Epiphyseal stippling 0.5417784103935672 1.29381621972384 0.1957289087781037 1.0 0.9728763789576228 12 O75381,Q14739,Q9UBM7 3 +Multiple joint contractures 0.4805057471271245 1.2900996439145769 0.1970160635080624 1.0 0.9728763789576228 20 P41440 1 +Babinski sign 0.3873074136967382 1.2851721976352048 0.1987321167692497 1.0 0.9728763789576228 88 Q13217,Q9Y4W6,P00846,Q92796,Q9NR77,O14773,Q15067,O95831,Q99720,P35637,P41440,Q6DKK2 12 +Limb ataxia 0.4531868732136681 1.2768493028824237 0.201655455451978 1.0 0.9728763789576228 26 Q9Y4W6,Q9H173,Q9NR77,Q10713,P41440 5 +Abnormality of pain sensation 0.4528284844615734 1.2757710423855233 0.2020364668230625 1.0 0.9728763789576228 25 Q9NR77,P39210,O95831 3 +Joint contracture of the hand 0.4355598272564353 1.2741440020796306 0.2026123865307774 1.0 0.9728763789576228 44 Q9NR77,Q15392,O75844,P42892,P98172 5 +Optic disc pallor 0.4236821322879671 1.27373335845747 0.202757929957885 1.0 0.9728763789576228 49 Q9Y4W6,P00846,Q5U5X0,O14936,Q6P4Q7,Q9H061,Q10713,Q8N183,O95831,Q9GZY8,O43676 11 +Unusual infection by anatomical site 0.5000986768869718 1.27028825053371 0.2039819718893438 1.0 0.9728763789576228 15 Q8TAA9,O95394,O15460,Q14739,P46100 5 +Heterogeneous 0.4438411358655853 1.2701400970885746 0.204034730930414 1.0 0.9728763789576228 39 P00846,P03915,Q9NR77,O75844,P46100 5 +Ovarian neoplasm 0.4915618288362777 1.2656794267604168 0.2056278768407666 1.0 0.9728763789576228 17 O60934,P04637,Q92878,P35222,Q01844,P49959,P20585,Q8IY37,P02545,P48735,O75874 11 +Occipital encephalocele 0.666198046636292 1.2616304294349157 0.2070818013274884 1.0 0.9728763789576228 5 Q10713 1 +Abnormal prostate morphology 0.6347598823913834 1.257458263324301 0.2085877430690141 1.0 0.9728763789576228 6 O60934,P04637,Q92878,P49959,P25054 5 +Paralysis 0.4240956115044088 1.2543609511441007 0.2097108390091393 1.0 0.9728763789576228 48 P50336,P36551,Q96CV9,Q9NR77,Q15165,Q15233,Q92804,P35637,P50995,P50402 10 +Type 1 muscle fiber atrophy 0.6035087581320024 1.2512525328220616 0.2108423575012488 1.0 0.9728763789576228 7 P61978,Q9BTV4,P50402 3 +Unsteady gait 0.4154121428070924 1.249173096629508 0.2116017697539822 1.0 0.9728763789576228 51 Q5JRX3,Q9NR77,Q10713,O95831,P52788,Q96F07 6 +Centrally nucleated skeletal muscle fibers 0.5915159183171697 1.244959054370206 0.2131468015706523 1.0 0.9728763789576228 8 P22626,P06753,Q13586,Q9H173 4 +Abnormality of the 5th toe 0.6317898858463789 1.244492838177862 0.213318233585011 1.0 0.9728763789576228 6 Q10713,Q14739 2 +Postaxial foot polydactyly 0.6317898858463789 1.244492838177862 0.213318233585011 1.0 0.9728763789576228 6 Q10713,Q14739 2 +Rimmed vacuoles 0.4956488717965236 1.244068286309825 0.2134744317949308 1.0 0.9728763789576228 15 O14979,Q8WXH0,Q9H173,P22626,P31483,P09651,Q9BTV4,P50402 8 +Gait ataxia 0.3613218032880445 1.2392779264400091 0.2152425903696919 1.0 0.9728763789576228 69 Q13217,Q9Y4W6,P00846,P03915,Q9H173,Q9NR77,O15118,O14773,Q10713,P41440 10 +Impaired mastication 0.6008780634114156 1.2392025501037127 0.2152704964290612 1.0 0.9728763789576228 7 O15460,P06753 2 +Abnormal tongue physiology 0.4870669572921118 1.2381856071424255 0.2156472470438721 1.0 0.9728763789576228 17 O95831 1 +Very long chain fatty acid accumulation 0.6302134643454368 1.2376105138359277 0.2158605140968859 1.0 0.9728763789576228 6 O75381 1 +Episodic respiratory distress 0.8942789729808194 1.2363463663719625 0.2163298431294533 1.0 0.9728763789576228 3 P00846 1 +Bird like facies 0.599620895593087 1.2334433507976192 0.2174103996721919 1.0 0.9728763789576228 7 O75844,P29084 2 +Basal ganglia cysts 0.5994507021963565 1.2326636484416875 0.2177012795660162 1.0 0.9728763789576228 7 P00846 1 +Aganglionic megacolon 0.4897917135309214 1.230512900834681 0.2185050990268164 1.0 0.9728763789576228 16 Q10713,P42892,P46100 3 +Abnormality of the musculature of the lower limbs 0.4463277850195991 1.2287273519214108 0.2191740475084531 1.0 0.9728763789576228 30 Q9NR77,Q8NAT1,P00846,P50402 4 +Abnormality of the pubic hair 0.5977014444451751 1.2246494346959491 0.2207073335380407 1.0 0.9728763789576228 7 P82650,Q8IY37 2 +Abnormal circulating pyruvate family amino acid concentration 0.4804234290453587 1.2243429580661958 0.2208228779165333 1.0 0.9728763789576228 18 P03915,P00846 2 +Type ii lissencephaly 0.657158665336282 1.2238996335553165 0.2209900918798939 1.0 0.9728763789576228 5 P07942 1 +Male pseudohermaphroditism 0.8907307768458592 1.223649434389703 0.2210845025272709 1.0 0.9728763789576228 3 P46100 1 +Cold induced muscle cramps 0.8905009719581077 1.2228273700479328 0.2213949054591191 1.0 0.9728763789576228 3 Q9NR77 1 +Postaxial hand polydactyly 0.559900368493545 1.2200416035456194 0.2224491039610654 1.0 0.9728763789576228 10 O00459,Q10713,Q9UM00,Q9UBM7,Q14739 5 +Patchy changes of bone mineral density 0.8895181728170158 1.21931206313583 0.2227257717945479 1.0 0.9728763789576228 3 Q13126 1 +Talipes equinovarus 0.3607016060134617 1.2186410703208022 0.2229804536525121 1.0 0.9728763789576228 70 P61978,Q8TAA9,P10412,Q9Y619,Q8TD16,Q9NR77,Q9UM00,Q15392,P52788,Q8NI60,Q9NWM8,Q9H3P2,P46100,P98175,P36543 15 +Fatigue 0.3711647507882996 1.2181411404297933 0.2231703423466513 1.0 0.9728763789576228 79 P53680,Q96CV9,Q13423,Q4J6C6,Q15165,Q70HW3,Q92804,O15460,P17252,Q8IWT6,P35637,Q14739,Q6UN15,P06753,P50995,P46100 16 +Adipose tissue loss 0.575023539461924 1.217468433315226 0.2234260396786438 1.0 0.9728763789576228 9 O75844,P29084 2 +Corneal ulceration 0.6552398305701024 1.2158911306223197 0.2240263972091951 1.0 0.9728763789576228 5 O75844 1 +Metatarsus valgus 0.7230576098520569 1.2137058450207343 0.2248600715672188 1.0 0.9728763789576228 4 Q9H173 1 +Increased susceptibility to fractures 0.4113364689760178 1.2118952635147555 0.2255524754743323 1.0 0.9728763789576228 51 Q14696,O75718,P07237,Q13126,Q32P28,P17252,P52788,Q14739,P22626,P48735,P06753,P39210 12 +Abnormal chorioretinal morphology 0.4439364817128445 1.2098078790769102 0.2263526221570102 1.0 0.9728763789576228 26 P56589,Q9Y619,O14936,Q10713,P04439,O75381 6 +Clumsiness 0.4680797924606175 1.209247089305212 0.2265679316257527 1.0 0.9728763789576228 20 Q9NR77,Q15067 2 +Focal dystonia 0.4679996090148889 1.2087252061681015 0.2267684345010816 1.0 0.9728763789576228 20 Q99720,P35637 2 +Limb undergrowth 0.4189123117687267 1.208626209229915 0.2268064825226203 1.0 0.9728763789576228 48 P25054,O75718,Q15392,P17252,Q96HY6,Q9UBM7,Q14739,P48735,P98172,P98175 10 +Abdominal pain 0.3686881517255895 1.203118043976534 0.2289306437574398 1.0 0.9728763789576228 78 P50336,P36551,Q70HW3,O15460,P23786,P35637,Q6UN15,P14174,P42892,P46100 10 +Agenesis of corpus callosum 0.3705148390704218 1.1977841124825457 0.2310010738441017 1.0 0.9728763789576228 80 P61978,P03915,Q14004,P48651,P29084,P49454,Q10713,Q15392,P78318,Q8NAT1,Q86XL3,P23786,P00403,P98172,O14497,Q9H3P2,P46100,Q969G3 18 +Decreased adipose tissue 0.4871158126574447 1.1937773561758946 0.2325650715346938 1.0 0.9728763789576228 15 O75844,P36543 2 +Abnormal circulating ferritin concentration 0.5903787220394828 1.1910952512353108 0.2336161939040208 1.0 0.9728763789576228 7 P36551,P41440 2 +Broad based gait 0.4595838866555473 1.1899180586186953 0.2340785999387185 1.0 0.9728763789576228 21 P29084,O14773,Q00577,P52788,Q12873,P98175 6 +Prostate neoplasm 0.6488960784192991 1.1894197175876782 0.2342745455767714 1.0 0.9728763789576228 5 P49959,P25054 2 +Alveolar ridge overgrowth 0.8652528548123894 1.1835076398365167 0.2366080205132958 1.0 0.9728763789576228 2 Q15392 1 +Proximal muscle weakness in upper limbs 0.4881669926431833 1.182351144262532 0.2370663999707929 1.0 0.9728763789576228 14 P50336,P50402,P36551 3 +Hypocholesterolemia 0.5780570882962129 1.181957872057527 0.2372224171329529 1.0 0.9728763789576228 8 Q9NVI7,P37268,Q9UBM7 3 +Epispadias 0.8788503404045541 1.1811991498195071 0.2375236189476217 1.0 0.9728763789576228 3 Q9Y619 1 +Tented upper lip vermilion 0.4576635645432705 1.1771378000287032 0.2391405099139483 1.0 0.9728763789576228 21 Q14696,Q4J6C6,P60953,Q00577,Q96F07,P46100 6 +Multiple lipomas 0.5763830900846247 1.174120723653651 0.240346673806111 1.0 0.9728763789576228 8 P53680,P03915,P25054 3 +Ketosis 0.476520320715976 1.1736639693255375 0.2405296475563385 1.0 0.9728763789576228 17 P53985 1 +Abnormality of the metaphysis 0.4195358597614311 1.1735888896894282 0.2405597335132299 1.0 0.9728763789576228 46 P07237,P48651,Q13126,P00813,O95831,Q96HY6,Q14739,P48735 8 +Abnormality of the leydig cells 0.8626427406198969 1.1732870908681274 0.2406806972652981 1.0 0.9728763789576228 2 P52788 1 +Cupped ear 0.5030892930550802 1.172262558429975 0.241091658914299 1.0 0.9728763789576228 13 P42892,Q15392 2 +Increased csf lactate 0.4011284784999395 1.171486427676974 0.2414033101552481 1.0 0.9728763789576228 53 P03915,P00846,Q8N183,O95831,Q8NI60,O43676 6 +Hyporeflexia 0.4077792924505192 1.1706451716568007 0.2417414322785904 1.0 0.9728763789576228 117 P50336,P00846,P03915,P35610,Q9H173,Q9NR77,Q10713,Q8TD16,Q15067,O95831,Q99720,Q9NSE4,P35637,P54802,P41440,Q96F07,Q8NAT1,P39210 18 +Retrocollis 0.8744906851429947 1.1656492795985738 0.2437562748066706 1.0 0.9728763789576228 3 Q99720 1 +Fasting hypoglycemia 0.874190467835505 1.1645790810943977 0.2441894154843555 1.0 0.9728763789576228 3 O43772 1 +Gastrointestinal obstruction 0.5157929342627275 1.1549944434520083 0.2480927019136509 1.0 0.9728763789576228 12 P42892 1 +Raynaud phenomenon 0.611094320801004 1.1541466134225655 0.2484400655878205 1.0 0.9728763789576228 6 O75844 1 +Posterior polar cataract 0.8570962479608442 1.1515991937179075 0.2494858128745825 1.0 0.9728763789576228 2 P08670 1 +Multiple gastric polyps 0.8570962479608443 1.151599193717907 0.2494858128745827 1.0 0.9728763789576228 2 P20585 1 +Hypotension 0.4359158483269245 1.1502097177676571 0.250057504700989 1.0 0.9728763789576228 27 P46100,O43772 2 +Restlessness 0.4288173168813031 1.1494367140924624 0.250375948417282 1.0 0.9728763789576228 39 P35610,Q15165,Q92804,P35637,P42892 5 +Rhabdomyolysis 0.5136661479546684 1.1436332930328823 0.2527757484473683 1.0 0.9728763789576228 12 O43772 1 +Arthritis 0.4266983830058807 1.1433289423326758 0.2529020427313537 1.0 0.9728763789576228 40 P28070,O15460,Q96HY6,P14174,O75844 5 +Biliary cirrhosis 0.6084350599903394 1.142543900814551 0.2532280088446617 1.0 0.9728763789576228 6 Q14739,P14174 2 +Abnormal peripheral nervous system physiology 0.4057034472639701 1.1359877759944697 0.2559616802843707 1.0 0.975786858284424 50 Q9NR77,O95831 2 +Knee flexion contracture 0.4327445874512039 1.1263277212405898 0.260026828177224 1.0 0.9830440686201288 28 Q8TD16,O00459,P37268,P23786,Q86XL3,P36543 6 +Cleft soft palate 0.3866962503111377 1.1241440793887192 0.2609519080851561 1.0 0.9857219916705066 56 P61978,Q9Y619,P48651,Q13428,Q92796,Q15392,P34897,Q15233,P52788,Q9NWM8,Q8NAT1 11 +Oral aversion 0.5553008018884887 1.1230944988202958 0.2613973622739725 1.0 0.9859267414004832 9 O14497,Q969G3,P35610,Q96GM5 4 +Abnormality of the anterior fontanelle 0.4306830226698012 1.1204568897456424 0.2625191136823339 1.0 0.9859267414004832 33 Q9Y619,O75718,O75381,Q32P28,P36543 5 +Abnormal head movements 0.5234990471627936 1.1170086253176594 0.2639906372736429 1.0 0.9859267414004832 11 Q99720 1 +Retinal vascular tortuosity 0.4735106754575319 1.1136341663114977 0.2654361626996988 1.0 0.9859267414004832 15 P03915,P00846 2 +Pleural effusion 0.5377468492590879 1.1101883947543931 0.2669178525988007 1.0 0.9859267414004832 10 P14174 1 +Abnormal size of the clitoris 0.4696977811025475 1.109943016152019 0.2670235825323566 1.0 0.9859267414004832 16 Q8IY37,Q9Y619,Q9UBM7,O75381 4 +Abnormal consumption behavior 0.4474455212415101 1.109165118211626 0.2673589573861317 1.0 0.9859267414004832 21 P35610,Q4J6C6 2 +Thick corpus callosum 0.8585795165382482 1.1090511233196612 0.2674081282807559 1.0 0.9859267414004832 3 O00459 1 +Self mutilation 0.5510604435312452 1.1028157517599606 0.27010718620331 1.0 0.9859267414004832 9 Q10713,Q9UM00,Q9UBM7 3 +Metaphyseal widening 0.4609333420024124 1.1027679569487312 0.2701279466752728 1.0 0.9859267414004832 18 Q96HY6,Q14739,O95831 3 +Megalencephaly 0.8566186078583302 1.102094705671831 0.2704205008492222 1.0 0.9859267414004832 3 O00459 1 +Increased intramyocellular lipid droplets 0.5985450762865241 1.099422455654374 0.2715838404145974 1.0 0.9859267414004832 6 Q8NI60 1 +Abnormal pleura morphology 0.4559107812960403 1.09883064125175 0.2718419442953044 1.0 0.9859267414004832 19 O15460,Q14739,P14174 3 +Aplasia hypoplasia of the optic nerve 0.4341586927469286 1.0984053136315304 0.27202754315228 1.0 0.9859267414004832 23 P61978,O95721,O14936,P49454,P37268,Q8WXI9,Q96KP1,Q9NVI7,P25054 9 +Atrophy degeneration involving the spinal cord 0.5975686061365064 1.09516814615076 0.2734429781229752 1.0 0.9859267414004832 6 Q9Y6X9,Q13217 2 +Impaired proprioception 0.4236759764069061 1.0902199627222655 0.2756162617630946 1.0 0.9859267414004832 37 Q13217,P00846,Q9NR77,P54802,P41440 5 +Abnormality of hand joint mobility 0.6910827667344436 1.0888179405788625 0.2762341785202933 1.0 0.9859267414004832 4 P52788,P48651 2 +Hyperextensibility of the finger joints 0.6910827667344436 1.0888179405788625 0.2762341785202933 1.0 0.9859267414004832 4 P52788,P48651 2 +Abnormal gastrointestinal motility 0.4327276795677451 1.0884324756771349 0.2764042308768486 1.0 0.9859267414004832 23 P50336,P61978,P03915,P36551,P35637,Q9UBM7 6 +Abnormality of the musculature of the upper arm 0.5676487649905031 1.0869844473472698 0.277043683127991 1.0 0.9859267414004832 7 O14979,Q8WXH0,Q9Y6X9,Q9BTV4,P50402 5 +Proximal upper limb amyotrophy 0.5676487649905031 1.0869844473472698 0.277043683127991 1.0 0.9859267414004832 7 O14979,Q8WXH0,Q9Y6X9,Q9BTV4,P50402 5 +Abnormal urinary color 0.6242868326896054 1.0868956587547087 0.2770829251235076 1.0 0.9859267414004832 5 P23786 1 +Respiratory failure 0.3611053259880519 1.085624375347736 0.2776452110424037 1.0 0.9859267414004832 62 Q5U5X0,Q9Y619,Q8TD16,Q96CV9,Q15165,Q8N183,Q70HW3,Q92804,P23786,P35637,P50995 11 +Upper limb muscle weakness 0.4262817643635603 1.0846487232618776 0.2780772665382207 1.0 0.9859267414004832 25 P50336,P00846,P36551,P50402,Q969G3 5 +Abnormal eating behavior 0.4536409793575044 1.084396623760054 0.2781889800642512 1.0 0.9859267414004832 19 P35610,Q4J6C6 2 +Abnormal fallopian tube morphology 0.6232062412437294 1.082403445541214 0.2790732979499375 1.0 0.9859267414004832 5 O60934,P49959,Q92878 3 +Abnormality of the incisor 0.4262913943705294 1.0819603876187571 0.2792701298982509 1.0 0.9859267414004832 26 Q9Y296,Q8WVM7,Q00577,Q96PZ0,P46100 5 +Fasting hyperinsulinemia 0.6885406464250676 1.0789242071910177 0.2806215165568688 1.0 0.9868969788539256 4 Q16836,P02545,P40939 3 +Optic disc coloboma 0.8499692551401969 1.078540567069618 0.2807925880908046 1.0 0.9868969788539256 3 Q10713 1 +Platyspondyly 0.4243238707991588 1.0686749824160453 0.2852161482709745 1.0 0.9911154953904118 32 O95831,Q32P28,Q96HY6,Q14739,P48735 5 +Abnormal choroid morphology 0.423606882930947 1.0604882934246966 0.2889225129648642 1.0 0.9920978080995272 27 P56589,Q9Y619,O14936,Q10713,P04439,O75381 6 +Severe global developmental delay 0.3430370846128632 1.0575509918858217 0.2902601955533552 1.0 0.9920978080995272 67 P00846,P03915,O14936,Q15067,O75381,Q00577,P55263,P07942,Q96PZ0 9 +Astrocytoma 0.5514474590137417 1.0574799262143646 0.2902926112760662 1.0 0.9920978080995272 8 P20585,P48735 2 +Ambiguous genitalia 0.4535925380931941 1.057062321579166 0.2904831456596661 1.0 0.9920978080995272 18 P46100,Q8IY37,Q15392,Q9UBM7 4 +Abnormal mitochondrial shape 0.6161798397953403 1.0532212943011148 0.2922395811235492 1.0 0.9920978080995272 5 Q9GZY8 1 +Ketotic hypoglycemia 0.8424144835414518 1.051849566127742 0.2928685739828505 1.0 0.9920978080995272 3 P53985 1 +Abnormal csf metabolite level 0.369092257337925 1.0513189885983598 0.2931121088183173 1.0 0.9920978080995272 59 P03915,P00846,Q8N183,O95831,Q8NI60 5 +Eversion of lateral third of lower eyelids 0.8309951060358817 1.0502061065122346 0.2936233625928777 1.0 0.9920978080995272 2 P61978 1 +Episodic tachypnea 0.5582159919267651 1.0438567392017564 0.2965516758603799 1.0 0.9920978080995272 7 P22695 1 +Anorexia 0.4200695042676087 1.0400124570491027 0.2983341132290631 1.0 0.9923620968679748 25 O15460,P46100,P35610 3 +Weakness of muscles of respiration 0.4200720213425613 1.0396680700310204 0.2984941399550109 1.0 0.9923620968679748 33 P50336,P36551,Q8TD16,Q9BTV4,Q15067,O95831,P22626,P06753,P50402 9 +Optic neuropathy 0.4185348596853144 1.0329164738833323 0.3016429886567335 1.0 0.9945824250326432 24 P03915,Q8N183,P00846 3 +Abnormal thoracic spine morphology 0.4198205993142546 1.031545852038405 0.3022849177704585 1.0 0.9945824250326432 28 O75844,Q9NSE4,O95831,O00459 4 +Arthralgia 0.417130546532133 1.0259999645631128 0.3048916007692177 1.0 0.9945824250326432 35 Q96HY6,P28070,P14174 3 +Neuronal loss in central nervous system 0.4916025954981267 1.0259755555914825 0.3049031063702137 1.0 0.9945824250326432 12 P35637 1 +Limb pain 0.5206737694635158 1.025695838628271 0.3050349764844422 1.0 0.9945824250326432 10 P00846,P36551,Q8WVX9 3 +Abnormal brainstem mri signal intensity 0.4294192215540158 1.0251653075445006 0.3052851946670118 1.0 0.9945824250326432 22 Q8N183,O95831 2 +Neoplasm of the endocrine system 0.4161014558415565 1.023816387280145 0.305922008686704 1.0 0.9946394137402416 36 P20585,P25054,O14497,P48735,P42892,P46100,Q969G3 7 +Abnormal lacrimal duct morphology 0.6089556998721457 1.0232757627916658 0.3061774800431702 1.0 0.9946394137402416 5 Q13428 1 +Breast hypoplasia 0.5807900847384009 1.0221976362709522 0.3066873693119141 1.0 0.9951718537111058 6 P98172 1 +Limb joint contracture 0.3736885136665998 1.0218609875377982 0.3068466991875023 1.0 0.9951718537111058 97 Q9Y619,Q8TD16,O00459,Q9NR77,Q15392,P37268,Q99720,Q86XL3,P23786,P35637,O75844,P50402,P42892,P98172,P36543 15 +Bilateral cryptorchidism 0.5198327921310913 1.0215417789525874 0.3069978255841428 1.0 0.9951718537111058 10 P36543,P37268,Q15233 3 +Abnormality of hair pigmentation 0.4339570488951969 1.019631425495602 0.3079032951869913 1.0 0.9960432982434796 21 Q13126,Q9Y4I1,P37268 3 +Hyperglycemia 0.5335327486620784 1.0191269891284542 0.3081426826360105 1.0 0.9960432982434796 9 O75844 1 +Osteopenia 0.3484082963387055 1.0123845778511429 0.3113542092953341 1.0 1.0 75 P61978,O75718,P07237,P29084,Q13126,Q32P28,Q9NSE4,Q9NWM8,O75844 9 +Abnormality of skeletal muscle fiber size 0.4460207478996517 1.0100161923940756 0.3124875322943947 1.0 1.0 18 P22626,P06753,O95831 3 +Erythema 0.4454703848468665 1.0066014422220972 0.3141263411234625 1.0 1.0 18 Q06136,P22830 2 +Increased serum pyruvate 0.4152343921852789 1.0029207351674183 0.3158991072289914 1.0 1.0 33 Q8N183,P22695,Q70HW3,O95831,Q9BWD1,O43676 6 +Spastic dysarthria 0.5391992476501569 1.000354313643251 0.3171390711815436 1.0 1.0 8 Q9Y4W6,Q96GW9 2 +Back pain 0.4197540866607711 0.9981905012472309 0.3181869915922215 1.0 1.0 23 P50336,Q8TAA9,P36551,Q9BTV4,P50402,Q969G3 6 +Airway obstruction 0.4504775692867948 0.9950072087314208 0.3197327583167584 1.0 1.0 16 Q96HY6 1 +Limb girdle muscle weakness 0.4137562820513898 0.9947403522597048 0.3198625632334475 1.0 1.0 25 O14979,Q8TD16,Q13126,P06753,Q14331 5 +Areflexia 0.3570203091719102 0.9944000389095252 0.3200281492043659 1.0 1.0 84 P61978,Q13217,P56589,O95394,Q8TD16,Q9H173,Q9NR77,Q9BQT8,Q15067,O95831,P41440,Q8NAT1,P39210 13 +Retinal dystrophy 0.3848273236343966 0.9934859525302971 0.3204731928606517 1.0 1.0 52 P56589,P00846,P03915,Q6P4Q7,Q10713,Q9Y4I1,Q15067,O75381 8 +Recurrent pancreatitis 0.8249199249702347 0.990373453552708 0.3219916158758376 1.0 1.0 3 P03915 1 +Abnormality of lower limb epiphysis morphology 0.4519320387800016 0.9869659284651904 0.3236593418468838 1.0 1.0 15 O95831 1 +Fever 0.356308220400144 0.9864002854547936 0.3239367250696494 1.0 1.0 84 P61978,P03915,P00846,P35610,Q9NR77,P00813,P28070,O15460,P23786,Q14739,P14174,Q6UN15,Q9Y2V7 13 +Abnormality of iron homeostasis 0.5991750702842744 0.9828466317563028 0.3256829272355332 1.0 1.0 5 Q15477,P28288 2 +Delayed ability to walk 0.347058859087169 0.9770017649857372 0.3285682785762367 1.0 1.0 63 O14936,Q96GM5,Q15233,P20700,Q99720,P35637,Q96PZ0,Q14004,Q92785,Q6ZXV5,Q12873,P34897,Q03252,Q8WVX9,P61978,Q96N66,Q10713,Q9NVV4,Q8N3U4,Q01105 20 +Steroid resistant nephrotic syndrome 0.597516798735501 0.9760068448005798 0.3290610723780847 1.0 1.0 5 Q12769,Q9BW27 2 +Mediastinal lymphadenopathy 0.5971078239085272 0.974320683779494 0.3298973378365653 1.0 1.0 5 O15460 1 +Hyperconvex fingernails 0.5964441713880994 0.9715851270314776 0.3312569845982827 1.0 1.0 5 O96028,P51812,P48651 3 +Proportionate short stature 0.4116161004497706 0.97126380977573 0.3314169255777601 1.0 1.0 31 Q9Y619,P48651,Q9H173,Q15392,Q96HY6,Q14739,Q96EY7 7 +Abnormal circulating carboxylic acid concentration 0.3604688542577249 0.971017699571313 0.3315394647663363 1.0 1.0 89 P03915,P00846,O14874,Q9Y619,P36551,P22695,P37268,P23786,P28288,Q14739,P41440,P55263,P48735 13 +Excessive daytime somnolence 0.451299517649165 0.9695637511782512 0.3322639886744687 1.0 1.0 14 P35610,Q969G3 2 +Impaired antigen specific response 0.5086625747543115 0.9664655337404776 0.3338112854215649 1.0 1.0 10 Q9Y2V7,P00813,O95394 3 +Abnormal thalamic mri signal intensity 0.5662759955109147 0.9593536968915236 0.337380592880887 1.0 1.0 6 Q9GZY8,Q969G3 2 +Abnormality of the peripheral nervous system 0.3659029357549976 0.9589699814066368 0.3375738679268887 1.0 1.0 95 P50336,Q9Y619,Q9NR77,Q15067,O95831,Q99720,P41440,P42892,P39210,P46100 10 +Streak ovary 0.566183027989648 0.9589522418315212 0.337582804958205 1.0 1.0 6 P82650,Q8IY37 2 +Abnormality of the larynx 0.4008091872942476 0.9552753539880208 0.3394384676688635 1.0 1.0 42 Q15165,Q92804,Q96HY6,P35637,Q9UBM7,Q14739,P50995,P36543 8 +Ventricular preexcitation 0.5384513494014738 0.9538086810208236 0.3401804943751698 1.0 1.0 7 P00846 1 +Central apnea 0.5381552873876846 0.9524642234648614 0.3408616017722876 1.0 1.0 7 P11166,Q10713 2 +Distal sensory impairment 0.4027866110577141 0.9500599236513008 0.3420818051910181 1.0 1.0 40 Q9NR77,P54802,O95831 3 +Abnormal circulating proteinogenic amino acid derivative concentration 0.4227367371616219 0.945475716957772 0.3444160623475953 1.0 1.0 21 P03915,P00846 2 +Chondrocalcinosis 0.5899650538673497 0.944920333005024 0.3446995500300471 1.0 1.0 5 P53680,P35670,P02545 3 +Membranoproliferative glomerulonephritis 0.8032626427406158 0.9440504401745896 0.3451438732817282 1.0 1.0 2 O95394 1 +Widow s peak 0.6527612496058952 0.9406033757244586 0.3469081513425047 1.0 1.0 4 P98172,P29372 2 +Hypochromic anemia 0.4604630393826742 0.9364197916542334 0.3490570917271247 1.0 1.0 13 Q9Y606,P46100,P28288 3 +Exodeviation 0.4048688168825243 0.9357251501176042 0.3494147180846698 1.0 1.0 24 Q5U5X0,Q15233,P55795,P98172,P46100 5 +Areflexia of lower limbs 0.4258435412700638 0.9352784850912944 0.3496448000813688 1.0 1.0 20 Q9NR77,Q15067 2 +Gonadal neoplasm 0.4203237963169211 0.9295827522766472 0.3525871610422371 1.0 1.0 21 Q92878,Q13423,P49959,P20585,Q8IY37,P48735 6 +Skin pit 0.5138032883372321 0.9253901874953218 0.3547629811083972 1.0 1.0 9 P61978,Q8N3U4,O96028,P16615 4 +Neoplasm of the adrenal cortex 0.5851968632672455 0.925349242729365 0.3547842719727947 1.0 1.0 5 P48735 1 +Limb girdle muscular dystrophy 0.5122559881779425 0.9180692269445968 0.3585826243538135 1.0 1.0 9 O14979,Q8WXH0,P09651,Q9BTV4,P50402 5 +Primary peritoneal carcinoma 0.6454456415279166 0.912600869228818 0.3614524970060939 1.0 1.0 4 O60934,P49959,Q92878 3 +Fasciculations 0.4022835083571618 0.9117197106696672 0.3619162852284585 1.0 1.0 35 Q96CV9,Q8TD16,Q9BQT8,O95831,P35637,P22626 6 +Extrapyramidal dyskinesia 0.8021765223770482 0.9112992344337708 0.3621377296967862 1.0 1.0 3 P35610 1 +Hemianopia 0.5196505418723977 0.9096364367801556 0.3630142760470898 1.0 1.0 8 P03915 1 +Sleep wake cycle disturbance 0.6445000450961982 0.908989958598598 0.3633554262464638 1.0 1.0 4 Q8N3U4,Q9UBM7 2 +Breast carcinoma 0.4258102238024729 0.9083193401097568 0.3637095273276465 1.0 1.0 19 P48735,P78549,P46100,P25054 4 +Soft tissue sarcoma 0.4028027298961601 0.9054361527613222 0.3652343701886014 1.0 1.0 30 Q13126,Q15392 2 +Sarcoma 0.3642007259026544 0.90537769081639 0.3652653304294766 1.0 1.0 56 Q13126,P48735,Q15392,Q92804 4 +Respiratory distress 0.3799317442565226 0.904218089822437 0.365879769812794 1.0 1.0 50 P00846,Q9Y619,Q8TCJ2,P03915,O95831,P23786 6 +Median cleft palate 0.7924959216965628 0.9033985584824462 0.3663144047870181 1.0 1.0 2 Q14739 1 +Kyphoscoliosis 0.3772354861669963 0.9011050204960056 0.3675324838244622 1.0 1.0 51 P10412,Q9NR77,Q15233,P52788,Q9NWM8,O75844,P46100 7 +Germ cell neoplasia 0.526223879164744 0.898423617128048 0.3689597501836541 1.0 1.0 7 P20585 1 +Eruption failure 0.5253128277799995 0.8943097504355938 0.3711561844999664 1.0 1.0 7 O75844 1 +Cortical cataract 0.7898858075040761 0.8935982306137525 0.3715368934036969 1.0 1.0 2 Q99797 1 +High narrow palate 0.4004909451695825 0.8895750136966611 0.3736941276665937 1.0 1.0 32 P61978,Q9Y619,P29084,P48651,Q15233,P23786,P52788,P25054,Q12873 9 +Synostosis involving digits 0.6391929431597811 0.8887629960302293 0.3741304668910648 1.0 1.0 4 Q15233 1 +Shallow orbits 0.4921884445801499 0.8856883880070534 0.3757854673236851 1.0 1.0 10 P61978,O75844 2 +Hip subluxation 0.5484368779511425 0.882638917251889 0.3774313946229246 1.0 1.0 6 Q02809,Q03252,Q9UBM7 3 +Hepatoblastoma 0.4915139620643088 0.8823957152529497 0.3775628519919911 1.0 1.0 10 Q96GM5,Q15477,P25054,O14497,Q969G3 5 +Flared metaphysis 0.5045387694626293 0.881639235861721 0.3779719302669551 1.0 1.0 9 Q96HY6,Q14739 2 +Extra axial cerebrospinal fluid accumulation 0.7862969004893963 0.8801596871367281 0.3787728086474917 1.0 1.0 2 Q03252 1 +Aplasia hypoplasia affecting the fundus 0.3980251734744334 0.8785163480455263 0.3796635698931914 1.0 1.0 26 P61978,O95721,O14936,P49454,Q9Y4I1,P37268,Q8WXI9,Q96KP1,Q9NVI7,P25054 10 +Complete duplication of phalanx of hand 0.6349288900317045 0.8725618282634113 0.3829019541313365 1.0 1.0 4 P34897 1 +Abnormal thalamic size 0.7903925866615447 0.8707860434661527 0.3838709870993786 1.0 1.0 3 Q9UPT5 1 +Tracheal stenosis 0.790342352823818 0.8706140920715363 0.3839648993827034 1.0 1.0 3 Q96HY6 1 +Nasolacrimal duct obstruction 0.6343589009814181 0.870399731482146 0.3840819933906998 1.0 1.0 4 Q13428 1 +Split nail 0.5452304388429967 0.8689278918135321 0.3848865726047523 1.0 1.0 6 P98172 1 +Abnormal endocrine physiology 0.5447916979617098 0.8670538932192786 0.3859124815035493 1.0 1.0 6 P50336 1 +Organic aciduria 0.393432265193642 0.8668083123996885 0.3860470468563299 1.0 1.0 39 P50336,P48735,P23786,O43772 4 +Spastic ataxia 0.5103590418062984 0.8667991440025128 0.3860520712097686 1.0 1.0 8 Q9Y4W6,Q9NVV4,Q96GW9 3 +Abnormality of the phalanges of the toes 0.4325149730527874 0.862369002511349 0.3884844924437627 1.0 1.0 14 O75844,P98172 2 +Abnormal corneal epithelium morphology 0.4180702875293798 0.8598215757548682 0.3898874040048206 1.0 1.0 19 P29084,Q9NSE4,Q14739,O75844,P39210 5 +Coxa valga 0.4094784260142421 0.8584581986573038 0.3906395030429626 1.0 1.0 21 O75844,P46100,Q9H173 3 +Progressive visual loss 0.3994673226691462 0.858164025206288 0.3908018976512197 1.0 1.0 23 P03915,O14773,P00846,Q969G3 4 +Gastrostomy tube feeding in infancy 0.3961502720655159 0.8575130178287432 0.3911614235274543 1.0 1.0 29 Q99720,P37268 2 +Abnormal full field electroretinogram 0.5166827616941071 0.8554430723902772 0.3923059071236827 1.0 1.0 7 P00846 1 +Abnormal light and dark adapted electroretinogram 0.5166827616941071 0.8554430723902772 0.3923059071236827 1.0 1.0 7 P00846 1 +Abnormal metabolic brain imaging by mrs 0.4269121321371786 0.8554289827673971 0.3923137043011824 1.0 1.0 16 P03915 1 +Abnormality of subcutaneous fat tissue 0.4278307523928403 0.8469636446043952 0.3970153857781189 1.0 1.0 15 O75844,P36543 2 +Telecanthus 0.3904238435079436 0.84304880163471 0.399201150872595 1.0 1.0 39 P10412,O00459,Q86XL3,O75844,P46100 5 +Red eye 0.4061752929014441 0.8369137350720007 0.4026410592886078 1.0 1.0 21 P29084,P28070,P34897,Q9NSE4,Q14739 5 +Abnormal soft palate morphology 0.3297766766793092 0.8313937041693173 0.405751254539199 1.0 1.0 64 P61978,Q9Y619,P48651,Q13428,Q92796,Q15392,P34897,Q15233,P52788,Q9NWM8,Q8NAT1 11 +Genu valgum 0.3923743088190015 0.82866180214143 0.4072958060674554 1.0 1.0 31 Q9NX62,Q9Y619,Q9NR77,Q9NSE4,P46100 5 +Abnormal exteroceptive sensation 0.373481510112264 0.8278389407417628 0.4077617182083177 1.0 1.0 49 Q9NR77,O95831,O15460,P54802,P39210 5 +Scrotal hypoplasia 0.4195088612049318 0.8278097453572885 0.4077782547521018 1.0 1.0 17 Q13428,P46100,Q8TCJ2 3 +Abnormality of endocrine pancreas physiology 0.622992829746136 0.8274740554263342 0.40796842144101 1.0 1.0 4 P53985 1 +Large intestinal polyposis 0.5016835115601522 0.827015164984608 0.4082284660825606 1.0 1.0 8 P20585,P78549 2 +Fatty replacement of skeletal muscle 0.5101385498067658 0.82610773422249 0.4087429807121996 1.0 1.0 7 P09651,P22626 2 +Abnormal blood sodium concentration 0.4797603797239395 0.8252438739896206 0.4092331492854204 1.0 1.0 10 P50336,P36551,Q13423 3 +Rod cone dystrophy 0.3887554644372303 0.8230871032568359 0.4104584622354386 1.0 1.0 38 P03915,Q15067,P00846 3 +Aplasia hypoplasia of the breasts 0.4917127929705463 0.8214550946194263 0.4113870924003788 1.0 1.0 9 P98172 1 +Papillary thyroid carcinoma 0.4911298949473162 0.818732297072321 0.4129391655807382 1.0 1.0 9 O14497,P25054,Q969G3,Q96GM5 4 +Abnormal glial cell morphology 0.355096030411673 0.8177385663405994 0.4135064837544238 1.0 1.0 56 P00846,Q10713,O95831,P35637,P48735 5 +Prominent eyelashes 0.4996106632158834 0.8175442545127781 0.4136174697622068 1.0 1.0 8 P20700,Q969G3,O14497,Q96GM5 4 +Polar cataract 0.7735161958206813 0.8134133222855944 0.4159811236620756 1.0 1.0 3 P08670 1 +Adenocarcinoma of the small intestine 0.7725861108500953 0.8102758379247611 0.4177816589740968 1.0 1.0 3 P78549 1 +Duodenal adenocarcinoma 0.7725861108500953 0.8102758379247611 0.4177816589740968 1.0 1.0 3 P78549 1 +Abnormality of cranial sutures 0.3404958591784305 0.8098733443767693 0.418012973250623 1.0 1.0 84 P61978,Q9NX62,Q14696,Q9Y619,O75718,P07237,P48651,P29084,O75381,O95831,Q32P28,Q00577,O75844,P98172,P36543 15 +Vocal cord paralysis 0.4099443532385684 0.8092340905801337 0.4183805093649502 1.0 1.0 19 Q9NR77,P50402 2 +Thoracic scoliosis 0.436757278555333 0.8072567738275274 0.4195185624720972 1.0 1.0 13 O75844,Q9NSE4,O00459 3 +Decreased circulating level of specific antibody 0.4973127969559714 0.8070621592297301 0.4196306720341682 1.0 1.0 8 Q9Y2V7 1 +Vertebral hypoplasia 0.4752505542367597 0.8034424051042611 0.4217190735300622 1.0 1.0 10 Q96HY6 1 +Abnormal morphology of the olfactory bulb 0.6163891609533223 0.8027125709511383 0.4221408853264421 1.0 1.0 4 Q13509,Q8N3U4,Q14683 3 +Coma 0.3872182426744543 0.8007214690516854 0.4232929108317713 1.0 1.0 36 P50336,P23786,O43772,P35610 4 +Speech apraxia 0.3855673016228454 0.7998830578019068 0.4237785546699719 1.0 1.0 24 Q9Y619,Q15233,Q00577,Q96PZ0,Q12873 5 +Decreased cervical spine flexion due to contractures of posterior cervical muscles 0.5286161485214663 0.7983578527233454 0.424662854358238 1.0 1.0 6 Q9BTV4,P50402,P02545,Q8WXH0 4 +Constriction of peripheral visual field 0.3953241281618645 0.7960574015898266 0.4259986723275302 1.0 1.0 22 Q9H061,P00846,O75381 3 +Serositis 0.4141378107460465 0.7958414423203674 0.4261242005643786 1.0 1.0 17 Q12769,O15460,Q9BW27,Q8NFH4,P14174,Q14C86 6 +Protruding tongue 0.4735586396050183 0.7952837686176278 0.4264484531321302 1.0 1.0 10 P46100 1 +Entropion 0.4730868682649373 0.7930108962343542 0.4277714744175156 1.0 1.0 10 O75844 1 +Hemifacial spasm 0.6136199342085915 0.7923713305237058 0.4281441910413592 1.0 1.0 4 Q969G3 1 +Paranoia 0.5519623144380654 0.7905360729140387 0.4292147639912334 1.0 1.0 5 P50336 1 +Abnormal circulating amino acid concentration 0.3647127807190822 0.7885285480287294 0.4303876067525947 1.0 1.0 51 P03915,P00846,Q9Y619,O14874,P41440,P55263 6 +Abnormal circulating free fatty acid concentration 0.6125589701346346 0.7884162454078959 0.4304532714523215 1.0 1.0 4 Q16836,P40939 2 +Asymmetric septal hypertrophy 0.7605220228384851 0.7850428400995791 0.4324284513692311 1.0 1.0 2 P54802 1 +Neurofibrillary tangles 0.7598694942903642 0.7826697773541879 0.4338210543152447 1.0 1.0 2 O15118 1 +Abnormality of the knee 0.3378347994497281 0.7804472982013523 0.4351276368829138 1.0 1.0 84 Q9NX62,Q9Y619,Q8TD16,O00459,Q9NR77,P48651,P37268,O95831,Q86XL3,Q96HY6,P23786,Q9NSE4,P46100,P36543 14 +Dyschromatopsia 0.4998058853462167 0.7800720909400044 0.435348442912026 1.0 1.0 7 Q9H061,Q9Y4W6,Q9H6K4 3 +Periauricular skin pits 0.4910089803823683 0.7784036080866965 0.4363311123748983 1.0 1.0 8 P61978,Q8N3U4,O96028 3 +Lipid accumulation in hepatocytes 0.3193328589470405 0.7759958192060818 0.4377514543976457 1.0 1.0 68 Q15067,O43772,P23786,Q8N511,P55263 5 +Neoplasm of the thyroid gland 0.391975930035404 0.773901511161904 0.4389890358918056 1.0 1.0 22 P20585,P25054,O14497,P42892,Q969G3 5 +Relative macrocephaly 0.384560467902287 0.772435273951667 0.4398566687119192 1.0 1.0 33 P48651,Q15392,Q15233,P25054,O75844,Q96PZ0 6 +Episodic pain 0.4163364519219245 0.7713047710948743 0.4405263050451007 1.0 1.0 14 P46100 1 +Abnormal autonomic nervous system physiology 0.3842550728380406 0.7699525487316469 0.4413280407941387 1.0 1.0 30 P50336,P42892,P41440 3 +Osteomyelitis 0.4119758404089961 0.7682682791807082 0.4423278159729507 1.0 1.0 16 Q13126,P39210,O95394 3 +Open mouth 0.3838885833949809 0.7673012236689153 0.4429024410677498 1.0 1.0 30 P61978,Q10713,Q15233,Q00577,Q86XL3,P46100 6 +Abnormal circulating copper concentration 0.5447297027913207 0.7616629910547881 0.4462611689666858 1.0 1.0 5 Q9Y487,Q10567 2 +Abnormal biliary tract morphology 0.3943913465987307 0.7606134282929119 0.4468879967781789 1.0 1.0 21 Q14739,P14174 2 +Juvenile aseptic necrosis 0.5185723966677289 0.7561490457920207 0.4495598388558939 1.0 1.0 6 Q9H173 1 +Cutaneous finger syndactyly 0.7523654159869353 0.755516859174003 0.4499389204790489 1.0 1.0 2 Q9Y619 1 +Abnormal circulating cholesterol concentration 0.3819396331283546 0.7548919058174177 0.4503138427879267 1.0 1.0 29 P34913,P37268,Q15392,Q8N511,Q14739,Q9UBM7,P50402 7 +Tubulointerstitial nephritis 0.5429851388298302 0.7547286481818959 0.4504118135324435 1.0 1.0 5 P23786 1 +Palmoplantar cutis laxa 0.7520391517128875 0.7543421721324958 0.4506437855383698 1.0 1.0 2 Q02809 1 +Excessive wrinkling of palmar skin 0.7520391517128875 0.7543421721324958 0.4506437855383698 1.0 1.0 2 Q02809 1 +Achilles tendon contracture 0.452120162105421 0.7543055455972839 0.4506657731544365 1.0 1.0 11 Q08J23,Q8TD16,Q15149,Q8WXH0,Q8N2K0,P02545,Q9BTV4,P50402 8 +Symphalangism affecting the phalanges of the hand 0.7557787550076052 0.7540682257407193 0.4508082555645201 1.0 1.0 3 Q15233 1 +Proximal symphalangism 0.7557787550076052 0.7540682257407193 0.4508082555645201 1.0 1.0 3 Q15233 1 +Sensory neuropathy 0.3820451297938708 0.753111890187521 0.4513826799620806 1.0 1.0 31 P00846,P03915,Q15067,P34897,O95831,P09651,Q9NSE4,P22626 8 +Abnormality of fundus pigmentation 0.6027891451245175 0.7521859712323049 0.451939228916286 1.0 1.0 4 Q9Y619 1 +Neoplasm of the skeletal system 0.3795160351137835 0.7514329105760139 0.4523921625889326 1.0 1.0 38 Q13126,P48735,Q92804 3 +Metaphyseal irregularity 0.4765145934764393 0.7508802391635445 0.4527247338565783 1.0 1.0 9 Q96HY6 1 +Abnormal levels of alpha fetoprotein 0.6020241593209354 0.7493642195727207 0.4536377106066092 1.0 1.0 4 P35222,Q15149,Q9NWH9 3 +Total anomalous pulmonary venous return 0.7543467243018451 0.7493245637810652 0.453661606034657 1.0 1.0 3 Q15392 1 +Narrow mouth 0.3192155223787699 0.7489544756766146 0.4538846446082534 1.0 1.0 70 Q9NX62,Q9Y619,Q14004,O00459,Q13428,Q15392,Q15233,P52788,O75844,Q96PZ0 10 +Abnormal tricuspid valve physiology 0.4031935480025335 0.7478077217796855 0.4545761438264355 1.0 1.0 18 P46100,Q15233 2 +Infectious encephalitis 0.4636250564473761 0.7476308344672098 0.4546828607190418 1.0 1.0 10 P46100 1 +Prominent superficial blood vessels 0.4251516610813148 0.7449842032529563 0.4562812695489009 1.0 1.0 13 O75844,P36543 2 +Intestinal polyp 0.4050191298165531 0.7419868096477363 0.4580953274016863 1.0 1.0 17 P20585,P42892,P78549 3 +High myopia 0.461541443770659 0.7376936564585806 0.4607006278052004 1.0 1.0 10 O15460,P52788 2 +Neoplasm of the breast 0.3778787965330361 0.7360400892070105 0.4617063009629678 1.0 1.0 26 Q9NYB0,P25054,P48735,P46100,P78549 5 +Narrow palpebral fissure 0.42343912235176 0.7358629995454647 0.4618140766909913 1.0 1.0 13 Q03164,Q8WXI9,P38159,O95394 4 +Tetraplegia tetraparesis 0.3663261759393347 0.7336966354515623 0.4631336495555753 1.0 1.0 47 P50336,Q5U5X0,P00846,O95831 4 +Emg neuropathic changes 0.3759226911337874 0.7329590856597223 0.4635833840344348 1.0 1.0 24 Q9NR77,P22626,O14773,P39210 4 +Waddling gait 0.3766003817653073 0.7320163929723285 0.4641585621892989 1.0 1.0 25 Q8TD16,Q4J6C6,Q9BTV4,P22626,P06753,P50402 6 +Distal amyotrophy 0.3483009442731161 0.727558830738547 0.4668836899547466 1.0 1.0 55 Q9Y4W6,Q9NR77,Q9BQT8,Q99720,P35637,P39210 6 +Ketonuria 0.4465832646055945 0.726911375296655 0.467280248294543 1.0 1.0 11 P53985 1 +Porphyrinuria 0.7469425721308975 0.7249203520618173 0.4685008944371089 1.0 1.0 3 P50336 1 +Elevated urinary dicarboxylic acid level 0.7469425721308975 0.7249203520618173 0.4685008944371089 1.0 1.0 3 P50336 1 +Respiratory paralysis 0.7469425721308975 0.7249203520618173 0.4685008944371089 1.0 1.0 3 P50336 1 +Elevated urinary delta aminolevulinic acid 0.7469425721308975 0.7249203520618173 0.4685008944371089 1.0 1.0 3 P50336 1 +Abnormality of the lymph nodes 0.3759838405222524 0.7242559352629759 0.4689086240785771 1.0 1.0 38 P00813,P28070,O15460,P14174,P46100 5 +T lymphocytopenia 0.4705962022468766 0.7236621329868667 0.4692731861009098 1.0 1.0 9 P00813,O95394 2 +High anterior hairline 0.4061149129740633 0.7232335248826154 0.4695364253351572 1.0 1.0 15 O15344,Q9H2P0,P29372,P98172,Q9H3P2,Q8N3U4 6 +Scleroderma 0.5349727823373208 0.7230423814711909 0.4696538466429636 1.0 1.0 5 Q9Y2U8,Q14739 2 +Metatarsus adductus 0.4455202703655485 0.7216714616684466 0.4704964918763772 1.0 1.0 11 Q08J23,Q15392,Q9UBM7,O96028,Q03252 5 +Increased sensitivity to ionizing radiation 0.5345164774014796 0.7212461729340116 0.470758068052248 1.0 1.0 5 Q96MG7,Q969G3 2 +Abnormal form of the vertebral bodies 0.329079350373089 0.7206227897892518 0.4711416282990508 1.0 1.0 81 Q9Y619,P07237,Q10713,P00813,O95831,Q32P28,Q96HY6,P54802,Q14739,Q9UBM7,P48735,Q9H3P2,P46100 13 +Abnormality of temperature regulation 0.3525271077067529 0.7191605369073388 0.4720420112700549 1.0 1.0 103 P61978,P00846,P03915,P35610,Q9NR77,P00813,P28070,O43772,O15460,P23786,Q14739,P14174,Q6UN15,Q9Y2V7 14 +Bifid uvula 0.3766528281903533 0.7154170448919512 0.4743513832764157 1.0 1.0 34 P61978,Q9Y619,P48651,Q92796,Q15392,P34897,P78318,P52788,Q8NAT1 9 +Cerebral hypoplasia 0.4436024229661518 0.7122341442534229 0.476319796764133 1.0 1.0 11 Q86XL3 1 +Epiretinal membrane 0.74097242685328 0.7053983304391706 0.4805623827184258 1.0 1.0 3 P04439 1 +Glioma 0.4293181744731386 0.700504032060134 0.4836125879956112 1.0 1.0 12 P20585,P48735 2 +Abnormal blood transition element cation concentration 0.441058369691298 0.6997491648096358 0.4840839667474832 1.0 1.0 11 Q9Y276,Q10567,Q15477,P28288 4 +Visual field defect 0.3638118754369367 0.698958478091352 0.4845779801175718 1.0 1.0 46 P56589,P00846,P03915,Q9H061,O75381,O15460,Q969G3 7 +Disproportionate tall stature 0.37246851142947 0.698357536922823 0.4849536249770441 1.0 1.0 26 Q9H3P2,P52788,Q9NWM8,Q96PZ0,P36543 5 +Biliary tract abnormality 0.3758102863449541 0.6979809222470341 0.4851891250191826 1.0 1.0 23 Q14739,P14174 2 +Sagittal craniosynostosis 0.5875611986090741 0.6964682987622544 0.4861356036080528 1.0 1.0 4 P61978,Q92785 2 +Bruising susceptibility 0.3741909042547534 0.696313688743774 0.4862324023865523 1.0 1.0 31 Q9NWM8,Q13126,P46100 3 +Abnormal number of granulocyte precursors 0.7357259380097839 0.6962766695168509 0.4862555810594291 1.0 1.0 2 Q07020 1 +Abnormal ldl cholesterol concentration 0.4153600123048784 0.6930997400202431 0.4882469608131661 1.0 1.0 13 P34913,P50402,P37268,Q8N511 4 +Abnormal granulocytopoietic cell morphology 0.7359660574412565 0.6891404865588888 0.4907348640652837 1.0 1.0 3 Q14980,Q07020 2 +Axial muscle weakness 0.58542187643312 0.6887216939397365 0.4909984215427512 1.0 1.0 4 Q8TD16 1 +Focal t2 hyperintense basal ganglia lesion 0.3789622147444045 0.6886592696066826 0.4910377133688359 1.0 1.0 22 P03915,P00846 2 +Peripheral axonal neuropathy 0.3488347864997383 0.6871095499489513 0.4920136966356472 1.0 1.0 53 Q9Y4W6,P00846,P03915,Q15067,P34897,O95831,P09651,P00403,P22626,P39210 10 +Torsion dystonia 0.732789559543224 0.6859719182206241 0.4927308168419617 1.0 1.0 2 P11166 1 +Tapered finger 0.3714858781706415 0.6853731185211671 0.4931085025497366 1.0 1.0 37 Q06136,P42892,P46100 3 +Aplasia hypoplasia involving bones of the thorax 0.3725798246651375 0.6841499273236435 0.4938804974166508 1.0 1.0 32 Q8TAA9,Q9Y619,P48651,Q96HY6,Q14739,O75844,P98172,P98175 8 +Distal peripheral sensory neuropathy 0.5250068370663401 0.6840319842594759 0.4939549692091947 1.0 1.0 5 P03915 1 +Increased c peptide level 0.7321370309950956 0.6836883990893567 0.4941719505348028 1.0 1.0 2 Q16836 1 +Abnormal nasolacrimal system morphology 0.4497922109053944 0.68208991274495 0.4951820986185031 1.0 1.0 10 Q13428 1 +Broad philtrum 0.4372744144905469 0.681253776433039 0.495710925981274 1.0 1.0 11 P11166,Q96GM5,Q9UM00,O14497,Q969G3 5 +Skin nodule 0.3886242613365743 0.678653393107862 0.4973575035352824 1.0 1.0 19 P48735,Q9NSE4,P35637,P34913 4 +Abnormality of lipoprotein cholesterol concentration 0.3995242397557674 0.6784442465311707 0.497490062786698 1.0 1.0 14 P34913,P50402,P37268,Q8N511 4 +Dyslexia 0.4603196215184535 0.6768178644685153 0.4985215221102348 1.0 1.0 9 P11166,Q13586,Q9H6K4,P25054 4 +Abnormal femoral head morphology 0.3912073276946851 0.676429189042828 0.4987681901735308 1.0 1.0 18 O95831 1 +Hypoplastic fifth fingernail 0.4759014761605204 0.6752319607203267 0.4995284038636143 1.0 1.0 7 O14497,Q969G3,Q92785,Q96GM5 4 +Intestinal pseudo obstruction 0.4755241944525565 0.6735993860211428 0.5005660436264636 1.0 1.0 7 P61978,P03915 2 +Progressive 0.3482133791315068 0.6726494994199801 0.501170302665984 1.0 1.0 103 Q5U5X0,Q9Y4W6,Q8N183,Q13126,Q9NR28,O95831,Q99720,P27544,P54802,P28288,P55263,P07942,P39210 13 +Mitochondrial myopathy 0.3703025437417031 0.6721915336380847 0.5014617701453055 1.0 1.0 29 P03915,Q8N183,P00846 3 +Abnormality of the scrotum 0.3644584080609792 0.6707812361291181 0.5023599026203018 1.0 1.0 43 Q96EK5,Q8TCJ2,Q9Y619,Q13428,Q9Y296,P46100,Q8IY37,Q9UBM7,Q96PZ0,P98172 10 +Brachydactyly 0.3110396063879504 0.66850120096623 0.5038137155507307 1.0 1.0 65 Q9NX62,Q06136,Q9H173,P48651,O95831,P46100,Q9UBM7,Q14739,P98172 9 +Ventricular escape rhythm 0.5205946223748064 0.6669163701465374 0.5048255538163113 1.0 1.0 5 Q9BTV4,P50402,Q8WXH0 3 +Alternating esotropia 0.7288072857353451 0.6660803496918671 0.5053597438689059 1.0 1.0 3 P25054 1 +Acne inversa 0.7265905383360503 0.664375128566409 0.5064502472444201 1.0 1.0 2 Q92542 1 +Vitiligo 0.4733098584142334 0.6640331564954912 0.5066690901492568 1.0 1.0 7 P03915 1 +Abnormal anatomic location of the heart 0.4573834221643803 0.6635405565663417 0.5069844137729076 1.0 1.0 9 O75844 1 +External ear malformation 0.393617150409486 0.6632273548768628 0.5071849544023972 1.0 1.0 16 Q00577,P56589,O75381 3 +Neoplasm of the pituitary gland 0.3960767794782212 0.6596800433439607 0.5094591760394771 1.0 1.0 14 P48735 1 +Hypoplastic fifth toenail 0.4640054449888662 0.6576109325058802 0.5107881677936135 1.0 1.0 8 O14497,Q969G3,Q92785,Q96GM5 4 +Symphalangism of middle phalanx of finger 0.7246329526916657 0.657600856962962 0.5107946437537809 1.0 1.0 2 Q15233 1 +Abnormality of the proximal phalanx of the thumb 0.7246329526916657 0.657600856962962 0.5107946437537809 1.0 1.0 2 Q15233 1 +Neoplasm of the male external genitalia 0.4639828461256802 0.6575114254452556 0.5108521268988069 1.0 1.0 8 Q8IY37,Q13423 2 +Inflammation of the large intestine 0.3941117810764413 0.6562946178584583 0.5116345798531197 1.0 1.0 15 P08183 1 +Macular thickening 0.471340735662372 0.6555492200273305 0.512114207434031 1.0 1.0 7 P04439 1 +Abnormal renal pelvis morphology 0.351570688324436 0.6547309116530021 0.5126410193714115 1.0 1.0 50 P61978,P56589,O75718,P49454,O75381,P23786,Q9UBM7,P46100,P98175 9 +Allergy 0.4710976890028538 0.6545035842106594 0.5127874187315489 1.0 1.0 7 P00813 1 +Polymicrogyria 0.3195767173621358 0.653291943512334 0.5135680853070421 1.0 1.0 78 P56589,Q96N66,O00459,Q8TD16,Q10713,O75381,Q15392,P37268,P34897,P23786,Q8IY37,Q8NAT1,Q16625,P36543 14 +Biliary atresia 0.7226753670472927 0.6508491321290668 0.5151438806013044 1.0 1.0 2 Q10713 1 +Optic nerve hypoplasia 0.3867694758536556 0.6503284243484448 0.5154801002841571 1.0 1.0 18 P61978,O14936,P49454,P37268,Q8WXI9,Q9NVI7 6 +Arthrogryposis multiplex congenita 0.3677785389287668 0.650237940198916 0.5155385372829744 1.0 1.0 34 Q8TD16,Q15392,Q96AA3,Q9UPT5,O75844,P06753 6 +Abnormal lactate dehydrogenase level 0.3867099348919359 0.6499795648841565 0.5157054216545633 1.0 1.0 18 Q5JRX3,P23786,P41440,Q9H173 4 +Cerebral edema 0.4543203443622049 0.649744274333901 0.5158574199829395 1.0 1.0 9 P23786 1 +Cystic hygroma 0.4695875907455756 0.6480144816253598 0.516975583845154 1.0 1.0 7 Q14739 1 +Ectropion 0.393828677052225 0.6475014608130633 0.5173074493763914 1.0 1.0 14 P61978,P29084,P25054 3 +Abnormality of the tarsal bones 0.3763034844684931 0.6456934278053983 0.5184779177158565 1.0 1.0 21 O75844,Q9UPT5 2 +Incomplete penetrance 0.3663843053530281 0.6446856603955722 0.5191309107923006 1.0 1.0 29 O14979,P00846,P36551,P03915,Q9NTZ6,P50995,Q92733,Q969G3 8 +Reduced forced vital capacity 0.572758906677146 0.6433208338799145 0.5200159404142297 1.0 1.0 4 Q9BQT8 1 +Neoplasm of fatty tissue 0.429309300388875 0.6426348860945872 0.5204610408173846 1.0 1.0 11 P53680,P03915,P25054 3 +Progressive gait ataxia 0.4411737143230004 0.6418254108521332 0.5209865486201153 1.0 1.0 10 P00846 1 +Accessory spleen 0.4903184075700602 0.6397981882280922 0.5223038106412328 1.0 1.0 6 P49454 1 +Underdeveloped supraorbital ridges 0.4172387149642652 0.6396780835360176 0.5223819067320579 1.0 1.0 12 P56589,O75381 2 +Abnormally large globe 0.4597172010090749 0.6387837573726199 0.5229636161769358 1.0 1.0 8 O00459 1 +Abnormal circulating carbohydrate concentration 0.3640863756900369 0.6386200535605414 0.5230701324056417 1.0 1.0 39 Q8N183,P22695,Q70HW3,O95831,Q9BWD1,O43676 6 +Erythrocyte inclusion bodies 0.5128150626316116 0.636991183815361 0.5241305862214207 1.0 1.0 5 O14936,Q9Y606 2 +Corneal opacity 0.3480711139435332 0.6246771434515407 0.5321829773093865 1.0 1.0 50 Q06136,P56589,P34913,P49454,O75381,Q9UBM7,O75844,Q9H3P2,Q16625 9 +Polydactyly 0.358604908031969 0.6243248344543493 0.5324142775304677 1.0 1.0 43 P61978,O00459,P49454,Q10713,Q15067,Q00577,P17252,Q9UBM7,Q14739,Q9Y2V7,Q9H3P2,P98172,P98175 13 +Dysdiadochokinesis 0.4019830639978392 0.6233997135774227 0.5330218861542659 1.0 1.0 13 Q6DKK2,P41440 2 +Shoulder girdle muscle weakness 0.4244116778408192 0.6191180005849161 0.5358386257827554 1.0 1.0 11 O14979,Q8TD16,P06753 3 +Abnormality of the mitochondrion 0.331462134945168 0.6168011804153288 0.5373658733052276 1.0 1.0 92 P03915,P00846,Q4J6C6,Q8N183,Q70HW3,O43772,P23786,O43676 8 +Abnormal vertebral morphology 0.3408774621911797 0.6163359484401664 0.5376728176356314 1.0 1.0 101 P61978,Q9Y619,O75718,P07237,Q10713,P00813,O95831,Q32P28,Q96HY6,P54802,Q14739,Q9UBM7,Q8IY37,P48735,Q9H3P2,P46100 16 +Abnormal muscle fiber protein expression 0.4620809326317899 0.6159609251581633 0.5379203093997136 1.0 1.0 7 Q9BTV4,P50402,P02545,Q8WXH0 4 +Gonadal dysgenesis 0.4235739296841496 0.6151140656026459 0.5384793937135597 1.0 1.0 11 P82650,Q8IY37,P29084 3 +Abnormal globus pallidus morphology 0.4617647058823548 0.6146183776412405 0.5388067748425998 1.0 1.0 7 P10515,O75306,P24928,Q9BU61,P22033,Q92947 6 +Abnormal number of incisors 0.5066660154961634 0.6135822648570137 0.5394914060426523 1.0 1.0 5 Q8N3U4,P38919 2 +Frequent falls 0.3607596843118253 0.6051984894915765 0.5450471193574704 1.0 1.0 37 Q9NR77 1 +Thin skin 0.3569927590034906 0.6043202963101342 0.545630714946947 1.0 1.0 24 O75844,Q13126,Q9Y619,P48651 4 +Abnormal arterial physiology 0.3579320358276975 0.59875345282028 0.5493373064148428 1.0 1.0 26 O15460,O75844,Q9NWM8 3 +Arnold chiari type i malformation 0.558979604912232 0.5948830082423006 0.5519216760512367 1.0 1.0 4 Q15233 1 +Zonular cataract 0.4301963066835595 0.5912865684030331 0.5543284276104601 1.0 1.0 10 P11166,Q99797,Q9H6K4,P08670 4 +Flexion contracture of digit 0.310337018618199 0.5878745873502678 0.5566164749839331 1.0 1.0 63 P10412,Q9Y619,Q14004,O75844,P42892,P98172 6 +Short palpebral fissure 0.3566926201049985 0.5854217076756597 0.5582641960649084 1.0 1.0 27 Q9Y619,Q14004,Q03164,P55795,O75844,P98175 6 +External ophthalmoplegia 0.3663651844682258 0.584030594775914 0.5591997283081169 1.0 1.0 21 Q5U5X0,P03915,Q8N183,Q9GZY8,Q5ST30 5 +Abnormal circulating estrogen level 0.4170022710224526 0.5839059778355232 0.5592835711169679 1.0 1.0 11 Q969G3 1 +Abnormal t cell proliferation 0.7020412742230617 0.5820232579406441 0.5605510149735591 1.0 1.0 3 O95394 1 +Reduced antigen specific t cell proliferation 0.7020412742230617 0.5820232579406441 0.5605510149735591 1.0 1.0 3 O95394 1 +Cutaneous cyst 0.7020234986945356 0.5819686670781941 0.5605877861949362 1.0 1.0 3 Q8TAA9,P25054 2 +Epidermoid cyst 0.7017944535073293 0.580324038974862 0.5616961194474899 1.0 1.0 2 P25054 1 +Mixed hypo and hyperpigmentation of the skin 0.7013707571801678 0.579965224191391 0.561938069444019 1.0 1.0 3 P52788,P55265 2 +Myotonia 0.4535106125280581 0.579812409018665 0.5620411285117162 1.0 1.0 7 Q00577,P50402 2 +Pili torti 0.701141924959211 0.578166696802069 0.5631515807676053 1.0 1.0 2 Q9Y276 1 +Decreased ldl cholesterol concentration 0.5541465410168349 0.5781560343772512 0.5631587787389363 1.0 1.0 4 P37268 1 +Abnormal aldolase level 0.497227619932073 0.5781069201778808 0.5631919352407535 1.0 1.0 5 Q9H173 1 +Atresia of the external auditory canal 0.404210083527366 0.5754020876131899 0.5650193925953113 1.0 1.0 12 Q13428 1 +Muscle fiber inclusion bodies 0.4150798430066251 0.5748467550360953 0.5653949426489793 1.0 1.0 11 P06753,O43676 2 +Diaphyseal thickening 0.6993581345042917 0.5738028255293642 0.5661012365056215 1.0 1.0 3 Q14739 1 +Fatiguable weakness of proximal limb muscles 0.4952868567834897 0.5708849764802757 0.5680776154533824 1.0 1.0 5 Q92734,P06753 2 +Partial agenesis of the corpus callosum 0.4141680688247102 0.5705617055872815 0.5682967830521153 1.0 1.0 11 Q15392 1 +Progressive cerebellar ataxia 0.3543478086478394 0.5612506289597547 0.5746266930863038 1.0 1.0 38 Q9Y619,Q8N183,O14773,P35637,Q8NI60,P41440 6 +Pericardial effusion 0.4704344985298842 0.5606234110683413 0.5750542885029861 1.0 1.0 6 P47985,P04062,P49748,P02545,Q14108 5 +Abnormal talus morphology 0.3731884351573185 0.5596240757033367 0.5757358794802641 1.0 1.0 17 O75844 1 +Narrow palate 0.3526246395143435 0.557266048547197 0.5773456688800751 1.0 1.0 40 P61978,Q14696,Q9Y619,P29084,P48651,Q15233,P23786,P52788,P25054,Q12873 10 +Impaired smooth pursuit 0.3748844230708231 0.5519899402948117 0.5809552455181619 1.0 1.0 15 P41440 1 +Hyperammonemia 0.3533758143461837 0.5510187763273884 0.5816208032674903 1.0 1.0 37 Q9Y619,P23786,O43772,P35610 4 +Somatic sensory dysfunction 0.3325679392147143 0.5504940101162208 0.5819805841506933 1.0 1.0 99 P50336,Q13217,P00846,Q9Y619,Q9NR77,O95831,O15460,P54802,P41440,P39210 10 +Abnormal nasal base 0.4096165179562802 0.5492860017857795 0.5828091923045746 1.0 1.0 11 O14497,Q969G3,Q13868,Q96GM5 4 +Urogenital sinus anomaly 0.6910904866469003 0.5487302366888873 0.5831905925734913 1.0 1.0 3 Q8IY37 1 +Abnormal circulating follicle stimulating hormone concentration 0.445704991020432 0.5473464629477721 0.5841407286531264 1.0 1.0 7 Q969G3 1 +Anemia of inadequate production 0.3060493220859223 0.5441128465911724 0.5863638206969712 1.0 1.0 63 Q9BQT8,P46100,P41440 3 +Abnormality of upper limb joint 0.339002439850271 0.5425608444525953 0.5874322043615012 1.0 1.0 106 Q9Y619,Q9H173,Q9NR77,Q15392,O95831,P37268,Q8WVM7,Q15233,P23786,O75844,P42892,P98172 12 +Cachexia 0.3676405689755225 0.5403152197552266 0.5889796640435767 1.0 1.0 18 Q99720 1 +Opisthotonus 0.3512908146471668 0.5380275315593959 0.5905580414994169 1.0 1.0 23 Q99720 1 +Synostosis of metacarpals metatarsals 0.6873368146214163 0.5374793191735144 0.590936566469761 1.0 1.0 3 O60828,Q15233 2 +Choanal stenosis 0.68733681462141 0.5374793191734961 0.5909365664697737 1.0 1.0 3 Q9H9Y6,P48651 2 +Abnormal basal ganglia mri signal intensity 0.3512261270187893 0.5371178590624891 0.5911862053636208 1.0 1.0 30 P03915,P00846,Q8NI60 3 +Congenital contracture 0.3494512206404757 0.5335432980836704 0.5936575471063537 1.0 1.0 40 Q8TD16,Q9Y6X9,Q15392,Q96AA3,Q9UPT5,Q9HD42,O75844,P06753 8 +Abnormal thyroid morphology 0.3509982600135313 0.5317148524415348 0.5949235035414997 1.0 1.0 36 Q13428,P00813,P20585,P25054,O14497,P48735,P42892,Q969G3 8 +Recurrent acute respiratory tract infection 0.6867862969004863 0.5314806604351007 0.5950857395110545 1.0 1.0 2 Q15149 1 +Death in infancy 0.3217246252740243 0.5288844672895295 0.5968855976808503 1.0 1.0 57 P46100,Q15067,O75381,O75718 4 +Abnormal length of corpus callosum 0.6851549755301741 0.5262728073209925 0.5986986736900359 1.0 1.0 2 P11177 1 +Abnormal ureter morphology 0.3599934144840089 0.5262447683166523 0.5987181525747642 1.0 1.0 20 O75844,P23786 2 +Hypoplastic fingernail 0.3696728256102543 0.5244651578286385 0.5999550475000273 1.0 1.0 15 P48651,Q96GM5,Q92785,Q14739,O14497,Q969G3 6 +Contractures of the joints of the lower limbs 0.3278273276541225 0.5201828748141759 0.6029361201478718 1.0 1.0 54 Q8TD16,O00459,P48651,P37268,Q99720,P23786,Q86XL3,P35637,P50402,P36543 10 +Palpebral edema 0.4810581319399175 0.5187607478859054 0.6039275934007751 1.0 1.0 5 Q12756,A6NHR9,Q14331,O00170 4 +Lower limb hypertonia 0.402418670232893 0.5160540839772659 0.6058166358372636 1.0 1.0 11 P46100 1 +Long palm 0.6798302872062828 0.5152389352045297 0.606386064553158 1.0 1.0 3 P16435,P52788 2 +Prematurely aged appearance 0.346923453068323 0.5147865542469476 0.6067021821318463 1.0 1.0 40 P48651,Q13126,Q9Y4I1,O75844,P36543 5 +Abnormal sharpey fiber morphology 0.4575981733001708 0.5110061521466361 0.6093467488855782 1.0 1.0 6 P53680,P02545 2 +Decreased proportion of cd4 positive helper t cells 0.4786260665958199 0.5100051703131897 0.6100478395623743 1.0 1.0 5 O95394 1 +Ethylmalonic aciduria 0.4781188765512781 0.5081852201863718 0.6113234549052737 1.0 1.0 5 P38117,P53597,P16219,Q16134 4 +Abnormality of the pulmonary vasculature 0.3476978057374131 0.5071647130564222 0.6120392519346343 1.0 1.0 35 O75718 1 +Abnormality of macular pigmentation 0.6768944217383019 0.5066373417036479 0.6124093023549859 1.0 1.0 3 Q9UM00 1 +Abnormal blistering of the skin 0.3607229909745224 0.5017037111914183 0.6158759535702696 1.0 1.0 18 P50336,Q06136 2 +Hyperlipidemia 0.3458227895947224 0.50055642683507 0.6166833347777321 1.0 1.0 30 O75844,P23786,P28070,P22830 4 +Cyclopia 0.6769983686786216 0.5005473245755672 0.6166897421883972 1.0 1.0 2 Q8N3U4 1 +Median cleft lip 0.6769983686786216 0.5005473245755672 0.6166897421883972 1.0 1.0 2 Q8N3U4 1 +Panhypopituitarism 0.6769983686786216 0.5005473245755672 0.6166897421883972 1.0 1.0 2 Q8N3U4 1 +Abnormal dura mater morphology 0.6769983686786216 0.5005473245755672 0.6166897421883972 1.0 1.0 2 Q8N3U4 1 +Fatigable weakness of skeletal muscles 0.4272522446544196 0.5004544115128321 0.6167551487336829 1.0 1.0 8 Q92734,P06753 2 +Clonus 0.3461347056447056 0.4999503569714271 0.6171100330639354 1.0 1.0 31 Q9BQT8,Q99720,P35637 3 +Poor appetite 0.3884162328600234 0.4997298237427328 0.6172653296843764 1.0 1.0 12 P46100 1 +Abnormal circulating ige level 0.4545470471977999 0.499407609115052 0.6174922597892418 1.0 1.0 6 P00813,O95394 2 +Atrophy degeneration involving the corticospinal tracts 0.3771637376777222 0.4987212026583572 0.6179758055459037 1.0 1.0 13 P00846 1 +Pituitary adenoma 0.4089875251237852 0.4964907966821927 0.6195481790234743 1.0 1.0 10 P48735 1 +Abnormal insulin level 0.3445408587138944 0.495527065221856 0.6202281219588426 1.0 1.0 23 O75844 1 +Difficulty walking 0.3024105804662828 0.4937218641384477 0.6215026218423017 1.0 1.0 76 P00846,Q9NR77,Q15067,Q99720,P35637,Q969G3 6 +Abnormality of the tongue 0.3133448566447507 0.493570729695092 0.6216093766947686 1.0 1.0 86 P61978,P56589,P48651,Q9BQT8,Q13428,Q10713,O75381,O95831,O15460,Q9UBM7,O75844,P46100,Q969G3 13 +Increased circulating lactate dehydrogenase concentration 0.386652530822381 0.4914539119726765 0.6231054415027593 1.0 1.0 12 P23786,P41440 2 +Proximal tubulopathy 0.3407519052871032 0.4911200686763873 0.6233415281531935 1.0 1.0 25 Q8N183,P03915,O43676 3 +Long hallux 0.5279626494327934 0.4902360681672651 0.6239668608217281 1.0 1.0 4 P52788 1 +Portal vein thrombosis 0.673409461663943 0.4893983997207454 0.6245596688029238 1.0 1.0 2 Q9NWH9 1 +Splanchnic vein thrombosis 0.673409461663943 0.4893983997207454 0.6245596688029238 1.0 1.0 2 Q9NWH9 1 +Epigastric pain 0.673409461663943 0.4893983997207454 0.6245596688029238 1.0 1.0 2 Q9NWH9 1 +Plagiocephaly 0.3447853697326007 0.4873724774896871 0.6259943940543218 1.0 1.0 33 O14936,Q10713,Q15233,Q8IY37,Q96F07,P98172,Q01105 7 +Macrodontia 0.3597699425564138 0.4863081112479337 0.6267487291536362 1.0 1.0 17 Q00577,Q96PZ0,Q8IY37 3 +Abnormality of male internal genitalia 0.4235260646304268 0.4851368676831921 0.6275792614153914 1.0 1.0 8 Q8IY37,P49959,P25054 3 +Prolonged neonatal jaundice 0.3594009607428667 0.4843292864242418 0.6281521946717519 1.0 1.0 17 O14936,O15118,P39210,P36551 4 +Generalized limb muscle atrophy 0.4231671620695429 0.4836684486391638 0.6286211884877788 1.0 1.0 8 Q9Y606,P06753 2 +Aplasia hypoplasia of the sternum 0.6684467799254485 0.4822028634659023 0.6296618428952059 1.0 1.0 3 Q9Y619 1 +Infantile spasms 0.3418964294467672 0.4820991214289525 0.6297355339383945 1.0 1.0 28 O14936,P03915,P00846 3 +Abnormality of the musculature of the hand 0.3437438377784069 0.4818349400718951 0.6299232064269722 1.0 1.0 37 Q9NR77 1 +Mesomelia 0.4492546647272788 0.4794797962734995 0.6315973378934876 1.0 1.0 6 Q14739 1 +Poor suck 0.3456115853766367 0.4791858832300149 0.6318063960788496 1.0 1.0 22 O75306,P22695,Q5T160,O60828,Q15233,P40939,Q9UBM7,Q8N3U4 8 +X linked recessive inheritance 0.3251782575293623 0.4791780164814748 0.63181199204388 1.0 1.0 53 Q92796,O14936,P38159,O95831,Q15233,P52788,P46100 7 +Subcutaneous nodule 0.3598167568573227 0.4788677676974102 0.6320327024987518 1.0 1.0 16 P48735,Q9NSE4,P35637 3 +Increased ldl cholesterol concentration 0.4146113082708271 0.477137122390616 0.6332644818252984 1.0 1.0 9 P34913,P50402,Q8N511 3 +Hyperlipoproteinemia 0.4146113082708271 0.477137122390616 0.6332644818252984 1.0 1.0 9 P34913,P50402,Q8N511 3 +Abnormal uvula morphology 0.3424849903821138 0.475177655751297 0.6346603518681277 1.0 1.0 38 P61978,Q9Y619,P48651,Q92796,Q15392,P34897,P78318,P52788,Q8NAT1 9 +Lower limb spasticity 0.3026431583829591 0.4730759210576372 0.6361590149729981 1.0 1.0 78 Q9Y4W6,P00846,Q9Y619,Q8N183,O95831,Q99720,P35637,Q6DKK2,P07942,P46100 10 +Tachypnea 0.355433524912889 0.4726697128669094 0.6364488378897917 1.0 1.0 18 P22695,Q9Y619,P35610 3 +Abnormality of circulating adrenocorticotropin level 0.3927462089324521 0.4722693734420349 0.6367345279898284 1.0 1.0 11 P46100 1 +Hypoglycemic coma 0.4126863107294697 0.4691231862864736 0.6389815867092599 1.0 1.0 9 P40939,Q16836,Q13423 3 +Colpocephaly 0.4263192573579429 0.4688808871078233 0.6391547786438905 1.0 1.0 7 Q9NVI1,O14974,Q8N3U4,Q8IY37 4 +Shoulder girdle muscle atrophy 0.519661436830706 0.4634214687494596 0.643062293054709 1.0 1.0 4 P06753 1 +Abnormal 3rd finger morphology 0.6639477977161456 0.4605260159864902 0.6451387021325485 1.0 1.0 2 Q14683 1 +Periorbital edema 0.3380928882254773 0.4556897984908776 0.6486130588896648 1.0 1.0 23 Q12769,P28070,Q9BW27,Q8NFH4,Q14C86,Q14331 6 +Non hodgkin lymphoma 0.3992444545785868 0.4544364571694178 0.6495147172510185 1.0 1.0 10 P00813 1 +Fetal ultrasound soft marker 0.3550235096312623 0.4539828302301362 0.64984118480905 1.0 1.0 16 P61978,O75381,P98172 3 +Sudden loss of visual acuity 0.6616639477977114 0.4536731919856434 0.6500640647789899 1.0 1.0 2 P35222 1 +Dysmenorrhea 0.6616639477977109 0.4536731919856415 0.6500640647789913 1.0 1.0 2 P02545 1 +Hypersomnia 0.6616639477977062 0.4536731919856285 0.6500640647790006 1.0 1.0 2 O95551 1 +Juvenile cataract 0.4224485600675398 0.4536274692277101 0.6500969790224307 1.0 1.0 7 Q8WVX9 1 +Skeletal dysplasia 0.3374814478597502 0.4502859544269522 0.6525042652822974 1.0 1.0 41 P56589,P07237,Q13428,O75381,O95831,Q96HY6,Q14739 7 +Neuronal loss in basal ganglia 0.4614630960156889 0.4496313512176305 0.6529762782708222 1.0 1.0 5 O75306,Q9BU61,P42858,Q99986 4 +Abnormal morphology of the radius 0.3776052679997775 0.4496149655415937 0.6529880952297369 1.0 1.0 12 Q32P28,P98175 2 +Multiple rows of eyelashes 0.6568915518155356 0.4495739691364512 0.6530176612411405 1.0 1.0 3 Q9Y606 1 +Stroke like episode 0.4406056311495516 0.4474623742392505 0.6545412487561486 1.0 1.0 6 P00403,P03915,Q96AA3 3 +Sclerosis of skull base 0.6559533312136154 0.4469665972080061 0.6548991777168498 1.0 1.0 3 Q14739 1 +Young adult onset 0.3973219470842376 0.4462639723156894 0.6554065774862341 1.0 1.0 10 P31483,O15118,P51649,P36551 4 +Abnormal proportion of cd8 positive t cells 0.512745906273358 0.441514866209956 0.6588403015208217 1.0 1.0 4 O95394 1 +Ophthalmoparesis 0.2951413712443039 0.4413691215138244 0.658945792934647 1.0 1.0 74 Q9Y4W6,P00846,Q5U5X0,P03915,Q10713,Q8N183,O75695,O00217,O15460,Q8IY37,Q9GZY8,P06753,Q5ST30,Q969G3 14 +Abnormal intraocular pressure 0.438703177316294 0.4405157980385786 0.6595635728022973 1.0 1.0 6 P04439,Q15043 2 +Proptosis 0.3259039788717643 0.4401286282759544 0.6598439483865257 1.0 1.0 50 P61978,Q9NX62,O75718,P07237,Q32P28,P52788,O75844,Q9H3P2,Q969G3 9 +Splenomegaly 0.3133494116166364 0.4386615176907483 0.6609068148169959 1.0 1.0 91 P36551,O14936,Q10713,P00813,P28070,Q15392,Q96HY6,P54802,Q14739,P14174,P28288,Q9Y2V7,P46100,Q16625 14 +Abnormality of the brainstem white matter 0.652716725852025 0.4380216105321309 0.6613706178996561 1.0 1.0 3 Q10713 1 +Multicystic kidney dysplasia 0.3518105522498072 0.4375126186539279 0.661739626767321 1.0 1.0 16 Q10713,O75381,Q9UBM7 3 +Type i diabetes mellitus 0.3748073085400755 0.4368952311554264 0.6621873305712329 1.0 1.0 12 P03915 1 +Visual acuity test abnormality 0.4577111054086461 0.4367856791376663 0.6622667857711542 1.0 1.0 5 Q969G3 1 +Multiple enchondromatosis 0.4375987249912047 0.4364994728636435 0.6624743816010119 1.0 1.0 6 P48735 1 +Dyskinesia 0.2863709125182599 0.4320916060605265 0.6656748351602082 1.0 1.0 67 O75569,P00846,Q14139,P03915,Q9H173,O14936,P11166,O75306,P35610,Q96N66,P49959,O00217,Q00577,Q96F07,Q9BTV4,Q01105 16 +Exercise induced muscle cramps 0.4362988243252624 0.4317880773714919 0.6658954456736617 1.0 1.0 6 P53985 1 +Abnormality of the clitoris 0.3452187627283858 0.4283386890370599 0.668404555168995 1.0 1.0 19 Q9Y619,Q8IY37,O75381,Q9UBM7 4 +Nuclear cataract 0.6490198434683818 0.427900249425697 0.6687237455041513 1.0 1.0 3 P08670 1 +Widened cerebral subarachnoid space 0.6490036522234078 0.4278561480888639 0.6687558552266697 1.0 1.0 3 P03915 1 +Abnormality of the autonomic nervous system 0.3241662490861891 0.4261782552335403 0.669977961055024 1.0 1.0 50 P50336,Q10713,Q15067,P41440,P42892,P46100 6 +Impaired vibratory sensation 0.3331744176029486 0.4256792386843043 0.6703415922851761 1.0 1.0 28 Q9NR77 1 +Embryonal neoplasm 0.3364197598999762 0.4245859609402669 0.6711385290310727 1.0 1.0 22 Q96GM5,P20585,Q8IY37,P25054,O14497,Q969G3 6 +Decreased methylmalonyl coa mutase activity 0.6512234910277233 0.4229461822955834 0.6723345270195877 1.0 1.0 2 Q9H3L0 1 +Decreased adenosylcobalamin 0.6512234910277233 0.4229461822955834 0.6723345270195877 1.0 1.0 2 Q9H3L0 1 +Congenital nystagmus 0.3475486285962828 0.4219559875510409 0.6730571428959671 1.0 1.0 17 Q96PZ0,P00846 2 +Syringomyelia 0.6458877284595358 0.4194063935492922 0.6749191522898457 1.0 1.0 3 Q9Y2U8,P35222 2 +Retinopathy 0.332877824777019 0.41925470700736 0.6750299942892817 1.0 1.0 29 Q9Y4I1,Q9H3P2,P00846 3 +Abnormality of the auditory canal 0.3467396188112934 0.4177875429119032 0.676102459526136 1.0 1.0 17 Q13428 1 +Ependymoma 0.6452349869451668 0.4176457606746808 0.6762061341508099 1.0 1.0 3 O75874,P25054 2 +Hypoplasia of the brainstem 0.332485255503589 0.4167431452657764 0.6768662923964857 1.0 1.0 29 Q96EK5,O14936,Q10713,Q96KP1,Q9UPT5,Q9Y320,Q9HD42,P07942,Q6ZXV5 9 +Meningioma 0.4124969509537877 0.4151175352254522 0.6780558633360148 1.0 1.0 7 Q969G3 1 +Abnormality of metacarpal epiphyses 0.5038335638395126 0.4138959184532184 0.6789503331589097 1.0 1.0 4 O96028,P51812 2 +Aplasia hypoplasia involving the metacarpal bones 0.3335736972014549 0.4080242991757357 0.6832558354195712 1.0 1.0 22 Q32P28,Q14739,Q9H173 3 +Tetraparesis 0.3329977201788917 0.4061752270629431 0.6846138548980696 1.0 1.0 35 P50336,Q5U5X0,P00846 3 +Adrenocorticotropic hormone deficiency 0.6450244698205491 0.4051836304260148 0.6853425366790438 1.0 1.0 2 O00170 1 +Muscle abnormality related to mitochondrial dysfunction 0.3327388810600608 0.4044421250539736 0.6858876285230564 1.0 1.0 35 P03915,Q8N183,P00846 3 +Abnormal macroscopic urine appearance 0.3439503345095068 0.4035086145267567 0.6865740987173354 1.0 1.0 17 Q12769,P36551,P23786,Q9BW27,Q8NFH4,Q14C86 6 +Progressive sensorineural hearing impairment 0.3863420082320764 0.4004495478310678 0.6888254364730417 1.0 1.0 10 P03915,Q9NSE4 2 +Tube feeding 0.29700912444409 0.3980110423043553 0.6906220461704391 1.0 1.0 61 P61978,P17480,Q14139,Q96N66,Q9HA77,O60762,P37268,Q15233,Q99720,P35637,Q9H2P0,Q96EY7,Q9GZY8,P06753,Q8N3U4,Q01105 16 +Neoplasm of the peripheral nervous system 0.3408666753027101 0.3951944209193699 0.692699409753637 1.0 1.0 18 P46100 1 +Brittle hair 0.3420919010271237 0.3940766542045954 0.693524446534826 1.0 1.0 17 Q9Y276,P29084,Q15477,Q9NVI7,Q9Y487,O75844 6 +Microscopic hematuria 0.4971724524323091 0.3937276537570119 0.6937821223834453 1.0 1.0 4 Q9BW27 1 +Retinal hemorrhage 0.4254616970378524 0.3931949963032589 0.6941754650951766 1.0 1.0 6 P36543 1 +Wide intermamillary distance 0.3271072329649462 0.3897596788851061 0.6967142619928932 1.0 1.0 23 Q96EK5,P61978,Q9UM00,Q96KP1,P23786,P52788,Q9UBM7 7 +Tissue ischemia 0.337406702807379 0.3865052378854043 0.69912252416007 1.0 1.0 19 O75844 1 +Juvenile onset 0.3291483422392116 0.3841506921831121 0.7008667615450535 1.0 1.0 39 Q9NR77,O15118,P54802,P41440,P39210,P50402 6 +Basal ganglia calcification 0.4041254737367077 0.3835681947007202 0.7012985170479455 1.0 1.0 7 P03915 1 +Dry skin 0.3292216756571454 0.3834781501166435 0.7013652680000877 1.0 1.0 33 Q06136,P00813,Q9NYB0,P37268,Q9Y2V7 5 +Visual loss 0.3185500945031954 0.3817133759915973 0.702673977432273 1.0 1.0 50 P00846,P03915,Q13428,Q10713,O14773,O15460,Q969G3 7 +Hepatic necrosis 0.3902285486067689 0.3786776058210255 0.7049272850036217 1.0 1.0 9 Q9NWH9,P35222,Q16836,P40939 4 +Exaggerated cupid s bow 0.4210433691495756 0.3778282144601332 0.705558212552595 1.0 1.0 6 P61978 1 +Gangrene 0.380419222518647 0.3763848000307123 0.7066308444573997 1.0 1.0 10 O15460 1 +Retrognathia 0.2896946587169511 0.3748264271641496 0.7077895587414853 1.0 1.0 75 Q4J6C6,Q13428,P37268,Q15392,Q9UPT5,Q9Y2V7,Q16625,O75844 8 +Intracranial hemorrhage 0.3240295962101895 0.3717737308492584 0.7100613237733544 1.0 1.0 23 O75844,P23786 2 +Gastrointestinal inflammation 0.3271859356966105 0.3714981119476199 0.710266561948758 1.0 1.0 22 P08183 1 +Atrial arrhythmia 0.4007615071559234 0.3711229834097901 0.710545933219213 1.0 1.0 7 P50402 1 +Intellectual disability moderate 0.2868512002866162 0.3685679361454517 0.7124497987375316 1.0 1.0 73 P61978,O95394,Q96N66,Q4J6C6,O14936,Q01105,P48651,Q92796,P29084,Q10713,P34897,P38159,Q8NI60,P25054,Q969G3 15 +Elbow flexion contracture 0.3197798542310727 0.3677869014517816 0.7130321366532795 1.0 1.0 24 P48651,P37268,P23786,Q9BTV4,P50402 5 +Ocular pain 0.487361713525072 0.3648028547165654 0.7152585739907291 1.0 1.0 4 Q15043 1 +Skeletal muscle hypertrophy 0.3233952588097234 0.3647291523699036 0.7153135950588103 1.0 1.0 44 Q9NR77,P61978,P46100 3 +Abnormality of the alveolar ridges 0.3988490216102581 0.3641094425309172 0.7157762859863914 1.0 1.0 7 Q15392,Q9UBM7 2 +Abnormal nipple morphology 0.2984851771769768 0.3640986345569169 0.7157843564180244 1.0 1.0 59 Q96EK5,P61978,P56589,P29084,Q15067,Q9UM00,Q96AA3,Q15233,P23786,Q96KP1,P52788,Q9UBM7,Q9H3P2,P98172 14 +Supernumerary nipple 0.3773097765938651 0.3639449214408058 0.7158991391095422 1.0 1.0 10 P61978,Q15233 2 +Facial edema 0.3190416532183549 0.363392925775992 0.7163113855331025 1.0 1.0 24 Q12769,P28070,Q9BW27,Q8NFH4,Q14C86,Q14331 6 +Hemiparesis 0.3373141745521157 0.3628320535535012 0.7167303459345138 1.0 1.0 15 P00403,P03915,Q969G3 3 +Scaling skin 0.3920566343500757 0.3616321851801643 0.717626909936963 1.0 1.0 8 O75844 1 +Septo optic dysplasia 0.6229223779228179 0.3595220174656879 0.719204609783179 1.0 1.0 3 Q8N3U4 1 +Abnormality of the frontal hairline 0.281144332125617 0.3583890925102892 0.7200521532100321 1.0 1.0 65 O60885,P36551,O95831,Q9H2P0,P98172,Q9H9Y6,Q969G3,P46783,Q13428,Q92785,O14497,Q9H3P2,Q9UM00,P61313,Q08J23,Q07020,P29372,Q8N3U4,Q96GM5 19 +Abnormality of the musculature of the upper limbs 0.2824227383817167 0.3577836897251853 0.7205051974131291 1.0 1.0 70 P50336,P46783,P61313,O14979,P36551,Q8TD16,Q13586,Q9Y6X9,Q9NR77,Q9BQT8,Q8WXH0,Q07020,Q9NVV4,Q14331,Q9Y487,Q9BTV4,P06753,P50402 18 +Avascular necrosis 0.3247200245034501 0.3576491377071755 0.7206059007570216 1.0 1.0 22 O75844,Q9H173 2 +Thick nasal alae 0.356227116363171 0.3553709216797751 0.7223117301680244 1.0 1.0 12 P11166,Q96GM5,Q92785,O14497,Q969G3 5 +Parkinsonism 0.3173065456105269 0.3531201057382679 0.72399840040584 1.0 1.0 24 Q99720,P35637 2 +Fetal akinesia sequence 0.432122433855679 0.3529944820331779 0.7240925773023399 1.0 1.0 5 P06753 1 +Primary adrenal insufficiency 0.3349337518145837 0.3516823248932266 0.7250765175220506 1.0 1.0 15 P56589,O75381,Q969G3 3 +Hiatus hernia 0.4310907903331195 0.3497666029678262 0.7265138647683287 1.0 1.0 5 P57740,Q8WUM0,P54886,Q9NPF4 4 +Exertional dyspnea 0.3337155728560659 0.3482638513643716 0.7276420389756613 1.0 1.0 16 O75844 1 +Bifid tongue 0.6182848015019983 0.347965719588752 0.7278659283982911 1.0 1.0 3 P61978 1 +Nephropathy 0.3298332789972124 0.3471580852107043 0.7284725580277249 1.0 1.0 19 Q10713,P03915 2 +Keratoconjunctivitis 0.3633580936042831 0.3465744363266155 0.7289110537733183 1.0 1.0 11 Q9NSE4,Q14739 2 +Single naris 0.6161879895561372 0.3428025181233722 0.7317470314326233 1.0 1.0 3 Q8N3U4,Q14683 2 +Cerebral hemorrhage 0.3525221468655339 0.3397812224273523 0.734021289826964 1.0 1.0 12 P23786 1 +Morphological abnormality of the corticospinal tract 0.3321941262881565 0.3389938839344158 0.7346143375838934 1.0 1.0 15 P00846 1 +Elevated circulating glutaric acid concentration 0.4779627815866669 0.3380096248964944 0.7353559346106919 1.0 1.0 4 P38117,Q16134,Q92947 3 +Abnormal echocardiogram 0.6139033942558751 0.3372212750303032 0.7359501004744704 1.0 1.0 3 Q969Y2,P49748 2 +Edema of the dorsum of hands 0.6189233278955866 0.3346079627655032 0.7379208374322408 1.0 1.0 2 Q9Y263 1 +Edema of the dorsum of feet 0.6189233278955866 0.3346079627655032 0.7379208374322408 1.0 1.0 2 Q9Y263 1 +Abnormality of the upper respiratory tract 0.3048471986937583 0.3331620761373751 0.739011943239146 1.0 1.0 93 Q15165,Q13428,P28070,Q92804,O15460,Q96HY6,P35637,P54802,Q14739,P50995,P46100,Q969G3 12 +Bifid scrotum 0.4077888221682793 0.333106938548237 0.7390535619992367 1.0 1.0 6 Q9UBM7 1 +Cutaneous syndactyly 0.383859019197342 0.3314357729604701 0.7403153474680164 1.0 1.0 8 Q9Y2U8,Q9Y619,P98175 3 +Long toe 0.3689286555101508 0.3311168093209325 0.7405562551425073 1.0 1.0 10 Q8WXI9,P23786,P52788 3 +Ovarian cyst 0.3407204059793968 0.3309214784460736 0.7407037977094981 1.0 1.0 13 P20585,P78549 2 +Subcutaneous hemorrhage 0.3199161067571716 0.3302059162230537 0.7412443768292889 1.0 1.0 42 Q9NWM8,Q13126,P46100,Q16625 4 +Hand polydactyly 0.3184228275881949 0.3293086226906395 0.7419224273066296 1.0 1.0 29 O00459,Q10713,Q15067,Q9UBM7,Q14739,Q9H3P2,P98172,P98175 8 +Chorioretinal coloboma 0.3886598029033506 0.3275319742695161 0.7432655634214378 1.0 1.0 7 Q10713 1 +Hypoplasia of the olfactory bulb 0.6159869494290282 0.3271163171404194 0.7435799108404557 1.0 1.0 2 Q13509 1 +Increased circulating androgen concentration 0.6156606851549689 0.3262897218829164 0.7442051638325311 1.0 1.0 2 P04637 1 +Long penis 0.6156606851549666 0.3262897218829108 0.7442051638325353 1.0 1.0 2 O00170 1 +Decreased activity of mitochondrial complex iii 0.4052777503112605 0.3248792199885097 0.7452724845906344 1.0 1.0 6 Q9Y584 1 +Aplasia hypoplasia of the uterus 0.3285900565431612 0.3241806433198414 0.7458012758321411 1.0 1.0 16 Q16740 1 +Incoordination 0.2756355099085125 0.32400656516801 0.7459330638440047 1.0 1.0 67 P00846,Q9Y619,Q9NR77,Q10713,Q15067,Q6DKK2 6 +Punctate cataract 0.4728180894462063 0.3237417193670824 0.7461335828806415 1.0 1.0 4 P08670 1 +Hemolytic anemia 0.3201203026772432 0.3235333195182649 0.7462913778626439 1.0 1.0 34 P00813,P22830,P36551,P41440 4 +Abnormality of epiphysis morphology 0.3060588368286698 0.3220235267489526 0.7474348713162557 1.0 1.0 53 Q9Y619,Q9H173,O75381,O95831,Q96HY6,Q9UBM7,Q14739 7 +Subsarcolemmal accumulations of abnormally shaped mitochondria 0.6137030995105951 0.321354702349549 0.7479416063397699 1.0 1.0 2 Q8TCS8 1 +Abnormality of the breast 0.3128504832087522 0.3205913000257489 0.74852013146429 1.0 1.0 102 Q15067,Q96AA3,Q15233,P23786,Q9UBM7,P98172,Q96KP1,Q8IY37,P25054,Q9H3P2,P46100,Q96EK5,P56589,Q9Y619,Q9NYB0,Q9UM00,P52788,Q8NI60,P48735,P78549,P61978,P29084,P49959 23 +Azoospermia 0.3656707553965348 0.3186445685498039 0.7499960528952074 1.0 1.0 10 Q8IY37 1 +Abnormality of the supraorbital ridges 0.3175025696897987 0.3179763079890998 0.7505029084298704 1.0 1.0 22 P56589,P38159,O75381 3 +Thick eyebrow 0.318096369206947 0.3177480968754506 0.7506760243784729 1.0 1.0 42 Q96EK5,O60885,P51812,Q08J23,Q03164,Q96GM5,Q9UM00,O95831,Q9Y2U8,P15586,Q92785,Q9NSE4,O14497,P98175,Q969G3 15 +Aplasia cutis congenita over the scalp vertex 0.61141924959216 0.3156506562813411 0.7522676837017359 1.0 1.0 2 Q15149 1 +Congenital localized absence of skin 0.61141924959216 0.3156506562813411 0.7522676837017359 1.0 1.0 2 Q15149 1 +Abnormality of the 1st metacarpal 0.3791929907393612 0.3146621691167885 0.7530181708196146 1.0 1.0 8 Q9UQE7,O60885,O60828,Q15233,Q9NVI1 5 +Rib fusion 0.3849242977006811 0.3144693688574336 0.7531645774019506 1.0 1.0 7 Q9H3P2 1 +Positional foot deformity 0.2996989005320711 0.3139222574684434 0.7535800852695944 1.0 1.0 90 P61978,P10412,Q9Y619,Q9NR77,Q15392,P52788,Q8NI60,Q9UBM7,Q9NWM8,Q9H3P2,P46100,P36543 12 +Abnormal circulating proteinogenic amino acid concentration 0.3174888244966417 0.3119949346742991 0.7550443728822103 1.0 1.0 32 P55263,P41440 2 +Facial diplegia 0.3782523781700724 0.3113185512445831 0.7555584656783485 1.0 1.0 8 P34897 1 +Redundant neck skin 0.3835623403384988 0.3097549630011834 0.7567473024812483 1.0 1.0 7 Q9Y487,P36543 2 +Stenosis of the external auditory canal 0.4005227049983721 0.3095230170317521 0.7569237061510852 1.0 1.0 6 P16435,P08754,O96028,P61254,P55011 5 +Dystrophic fingernails 0.3527742925059215 0.3045088747081196 0.7607402325435941 1.0 1.0 11 O75844 1 +Encephalocele 0.3526957407883083 0.3042038197655695 0.7609726149110758 1.0 1.0 11 Q13428,Q10713 2 +Myopathic facies 0.3985909930506333 0.3033701453174457 0.7616077948530062 1.0 1.0 6 Q00577 1 +Lymphoma 0.3111303440001581 0.3032200831386128 0.7617221449097964 1.0 1.0 26 P46100,O95394,P00813,P78549 4 +Impaired distal proprioception 0.6055464926590448 0.3012505448417066 0.7632234496490664 1.0 1.0 2 O14802 1 +Supernumerary spleens 0.3809357242395009 0.3007370785885668 0.7636149922436466 1.0 1.0 7 P49454 1 +Abnormal glycosylation 0.314140872525072 0.2999598024910495 0.7642078174872169 1.0 1.0 22 Q9Y2V7,Q8TCJ2,Q8N511 3 +Micropenis 0.2909537553381532 0.2986187059108361 0.7652309910907893 1.0 1.0 59 Q8TCJ2,Q9Y619,O14936,Q10713,Q9UBM7,P42892,P46100 7 +Abnormal paranasal sinus morphology 0.3078439205836241 0.2985275598780987 0.7653005447594021 1.0 1.0 24 P28070,P46100 2 +Acquired abnormal hair pattern 0.3801322853035886 0.2979983830229948 0.7657043977521116 1.0 1.0 7 O75844,P25054 2 +Increased adipose tissue 0.5972584856396885 0.2979925435031518 0.7657088546660038 1.0 1.0 3 O14802,P02545 2 +Abnormality of bone mineral density 0.3376717417055558 0.2966916943262145 0.7667018986513394 1.0 1.0 130 O75718,P07237,Q13126,O95831,Q13428,Q32P28,Q96HY6,P54802,Q14739,Q8IY37,O75844,Q9H3P2,P48651,Q15392,P52788,Q9NSE4,P61978,P29084,Q9NWM8 19 +Abnormality of long bone morphology 0.3658712596296399 0.2963961298544823 0.7669275805522371 1.0 1.0 162 Q9NX62,O75718,P07237,Q9NR77,O14936,Q13126,P37268,O95831,Q9UBM7,Q96PZ0,P98172,Q9H173,O75381,Q32P28,Q96HY6,Q14739,O75844,P46100,P56589,Q9Y619,P48651,P00813,P48735 23 +Abnormality of the columella 0.321889884164933 0.2935821460450409 0.7690772202710989 1.0 1.0 16 P49454,P55795,P36543 3 +Chordee 0.3953471731588059 0.2931515053486804 0.7694063495716568 1.0 1.0 6 P16435,O14974,P48651 3 +Dermal atrophy 0.3104042556897183 0.2928189625660135 0.7696605332098945 1.0 1.0 27 O75844,Q15392 2 +Hypoproteinemia 0.6016313213702995 0.2918671617866932 0.770388191915512 1.0 1.0 2 P49748 1 +Molar tooth sign on mri 0.4597025787722164 0.2887038231811841 0.772808036755908 1.0 1.0 4 Q10713 1 +Telangiectasia of the skin 0.3198781102261586 0.2869452183710193 0.774154266394681 1.0 1.0 17 P46100 1 +Concentric hypertrophic cardiomyopathy 0.5918376632855783 0.2857774643962176 0.775048569435407 1.0 1.0 3 P03915 1 +Corneal erosion 0.4096531915913073 0.2856192897237173 0.7751697275966305 1.0 1.0 5 P39210 1 +Hamartoma 0.3190639562751503 0.2832332783712922 0.7769980198849689 1.0 1.0 17 P20585,P48735 2 +Hypoplasia of the iris 0.4573086358868709 0.2825224176369154 0.7775429596290704 1.0 1.0 4 O96028,Q13586 2 +Contractures of the large joints 0.5970636215334314 0.28114210764333 0.7786014058136794 1.0 1.0 2 Q9Y263 1 +Osteopetrosis 0.5893397831470335 0.2802440947407955 0.7792902387329323 1.0 1.0 3 Q15392 1 +Biparietal narrowing 0.363371128481437 0.2792067249926375 0.7800861829894101 1.0 1.0 9 Q10713 1 +Elevated lactate pyruvate ratio 0.4554358472086088 0.2777339412780489 0.7812166038362185 1.0 1.0 4 P53597,Q96RP9,O96000 3 +Aspiration pneumonia 0.3063580917204963 0.2761121844689612 0.782461902468579 1.0 1.0 26 Q96EY7,O95721,Q96GM5,P78318,Q00577,P20700,Q92734,O14497,P06753,Q8N3U4,Q969G3 11 +Scarring alopecia of scalp 0.5944535073409352 0.2751220545384733 0.7832224680851161 1.0 1.0 2 Q15149 1 +Inflammatory abnormality of the eye 0.3123055483354418 0.2724805809497869 0.7852525207511869 1.0 1.0 39 P04439,P28070,Q9NSE4,Q14739,P14174 5 +Temperature instability 0.3670269823771033 0.2724348020606163 0.7852877161409069 1.0 1.0 8 Q8N3U4,P35270 2 +Abnormal serum iron concentration 0.4525693127151396 0.2704857354682535 0.7867865895260955 1.0 1.0 4 Q15477 1 +Abnormal hair laboratory examination 0.3645890067970959 0.2642473871085384 0.7915892986719613 1.0 1.0 8 Q15477,P29084 2 +Sparse eyebrow 0.3100197206648146 0.2641504382071589 0.7916639995737396 1.0 1.0 33 Q96EK5,P61978,Q14696,P60953,Q9UM00,Q00577,P52788,Q9Y2V7,O75844 9 +Aplasia hypoplasia of the skin 0.3012147255495037 0.2611786337706321 0.7939547542087957 1.0 1.0 51 Q9Y619,P48651,Q13126,Q15392,Q15126,Q9NWM8,O75844,Q9H3P2 8 +Telangiectasia 0.3094565344450249 0.26082401630927 0.7942282229795103 1.0 1.0 33 P03915,P00846,P46100 3 +Calvarial hyperostosis 0.4007794491234171 0.2608035442552027 0.7942440110950069 1.0 1.0 5 P09651,P22626 2 +Atopic dermatitis 0.400322213424821 0.2595539395959812 0.7952078696970468 1.0 1.0 5 O95394 1 +Abnormality of the endometrium 0.3627867341321857 0.2582560404334189 0.7962093103472176 1.0 1.0 8 P78549 1 +Widened subarachnoid space 0.3052485644166324 0.2577909440587505 0.796568253927852 1.0 1.0 28 P03915,O95831 2 +Panhypogammaglobulinemia 0.3836304231174881 0.2574690102892889 0.7968167352996742 1.0 1.0 6 P29084 1 +Decreased muscle mass 0.3132042087999052 0.2572191702457505 0.7970095860435202 1.0 1.0 14 Q8TAA9,Q02809,P52788,P36543 4 +Abnormal atrioventricular valve physiology 0.3084605016594749 0.256946246757597 0.7972202689894932 1.0 1.0 43 O75844,Q15233,P46100,O00459 4 +Abnormality of the musculature of the thigh 0.3619806426193395 0.255593351494781 0.798264852661714 1.0 1.0 8 Q9BTV4,O14979,P50402,Q8WXH0 4 +Focal white matter lesions 0.3980719818528991 0.2534464413230431 0.799923243832128 1.0 1.0 5 O00443,O00584,Q9H2P0 3 +Severe demyelination of the white matter 0.5840130505709511 0.2518428920915696 0.8011625024666524 1.0 1.0 2 Q96C36 1 +Abnormal uvea morphology 0.2962418494227132 0.2515582399059762 0.8013825404295909 1.0 1.0 93 P56589,Q9Y619,Q9NR77,Q13428,P49454,Q10713,Q9Y4I1,O75381,O14936,P04439,Q9UBM7,P14174,Q9H3P2 13 +Diabetes insipidus 0.3386531193785201 0.2514796893198537 0.8014432633105619 1.0 1.0 11 P35222,O15460,Q8N3U4,Q9BZH6,Q14683 5 +Hypoplasia of the ear cartilage 0.5750652741514357 0.2498009127718361 0.802741313831854 1.0 1.0 3 Q8WUM0,Q9NPF4 2 +Posteriorly rotated ears 0.3038973411249321 0.2459809000811399 0.8056970178554514 1.0 1.0 101 P56589,Q14696,Q9Y619,Q14004,Q4J6C6,Q10713,Q15392,P37268,O75381,Q9H3P2,Q8NAT1,P23786,Q9UBM7,P42892,P46100 15 +Meningitis 0.3589293499734862 0.2456107531485447 0.8059835643735274 1.0 1.0 8 O15460,Q8TAA9 2 +Apraxia 0.2844995415774711 0.2446016331094256 0.806764899429055 1.0 1.0 59 Q9Y4W6,Q9Y619,P11166,Q10713,O14773,Q9Y296,P49959,Q15233,Q00577,P35637,Q6DKK2,Q96PZ0,Q5JTZ9,Q12873,P35270 15 +Progressive hearing impairment 0.328052060214088 0.2432433942010665 0.8078168524106524 1.0 1.0 12 P03915,Q9NSE4 2 +Gastric ulcer 0.5797716150081446 0.2427565064409127 0.8081940306181483 1.0 1.0 2 Q8N5K1 1 +Spontaneous recurrent epistaxis 0.5797716150081446 0.2427565064409127 0.8081940306181483 1.0 1.0 2 P35579 1 +Bulbar palsy 0.3437000681289562 0.2391577980470665 0.8109832254572895 1.0 1.0 10 P35637 1 +Mildly elevated creatine kinase 0.3060636454593145 0.2387356712629777 0.8113105547169228 1.0 1.0 20 Q16836,Q7Z406,P31483,P09651,Q92734,P40939,P06753,P39210 8 +Prenatal movement abnormality 0.2856306758649002 0.2361651307567915 0.8133045358937205 1.0 1.0 58 P56589,Q4J6C6,Q70HW3,Q9UBM7,Q96F07,O75844,Q9H3P2 7 +Abnormality of the fontanelles or cranial sutures 0.3068570907727984 0.2359287456372172 0.8134879620015427 1.0 1.0 105 P61978,Q9NX62,P56589,Q14696,Q9Y619,O75718,P07237,P48651,P29084,O75381,O95831,Q32P28,Q00577,P98172,O75844,P46100,P36543 17 +Crumpled long bones 0.5681470844716496 0.2357828081433812 0.8136012092058915 1.0 1.0 3 O75718 1 +Incisor macrodontia 0.3082111524479778 0.2351334627187727 0.8141051471735288 1.0 1.0 15 Q00577,Q96PZ0 2 +Abnormal incisor morphology 0.3082111524479778 0.2351334627187727 0.8141051471735288 1.0 1.0 15 Q00577,Q96PZ0 2 +Severe combined immunodeficiency 0.360240276981745 0.2333017669921668 0.8155270866013917 1.0 1.0 7 P00813 1 +Retinal dysplasia 0.3490963810633605 0.2309261021641007 0.8173722121283604 1.0 1.0 9 Q10713 1 +Emotional lability 0.2923875406152502 0.2300113323130714 0.8180829638723324 1.0 1.0 54 Q15165,Q8N183,Q92804,P35637,P50995 5 +Papillary renal cell carcinoma 0.3891283620746138 0.2298789235095726 0.8181858543808496 1.0 1.0 5 Q9NWH9,Q92733 2 +Neoplasm of the pancreas 0.3002417994326939 0.2288851244794018 0.8189582026353643 1.0 1.0 22 Q92878,Q01844,Q9NYB0,P49959,P25054,P78549 6 +Abnormal urine phosphate concentration 0.5725938009787802 0.2278742761517188 0.8197439812947482 1.0 1.0 2 P35670 1 +Abnormal drinking behavior 0.5725938009787802 0.2278742761517188 0.8197439812947482 1.0 1.0 2 Q8N5K1 1 +Hyperphosphaturia 0.5725938009787802 0.2278742761517188 0.8197439812947482 1.0 1.0 2 P35670 1 +Childhood onset 0.3049737094060774 0.2271372523984501 0.8203170177353445 1.0 1.0 37 Q9NR77,Q5JRX3,P22830 3 +Abnormal metatarsal morphology 0.2994765863872706 0.2251420045462768 0.8218688047871876 1.0 1.0 22 Q15392,Q9UBM7,Q9H173 3 +Pain 0.3655378928884501 0.2249678164203433 0.8220043112978686 1.0 1.0 171 P36551,Q9NR77,O14936,P23786,P35637,P50995,Q969G3,P00846,Q15165,P28070,O15460,Q96HY6,Q14739,P14174,O75844,P42892,P46100,P50336,Q92804,Q6UN15,P48735,Q70HW3 22 +Abnormality of circulating enzyme level 0.2920757470578847 0.2229679226170791 0.8235604721044674 1.0 1.0 92 Q5JRX3,Q9Y584,Q9H173,Q9BTV4,O43772,O95831,Q8NAT1,P23786,Q9NWM8,Q9Y2V7,P53985,P39210,P50402 13 +Variable expressivity 0.2792819282003128 0.2227404690783703 0.8237375027119194 1.0 1.0 80 Q9Y4W6,P03915,Q8TD16,Q9NR77,O60762,Q13868,P11166,Q70HW3,Q9H061,P49959,O00217,Q00577,P00403,Q8NI60,P06753 15 +Abnormal metacarpal morphology 0.2988117116580979 0.2224253472313463 0.8239827817388412 1.0 1.0 28 Q32P28,Q9NX62,Q14739,Q9H173 4 +Congenital diaphragmatic hernia 0.3032037992749862 0.2198737526564088 0.8259694784490199 1.0 1.0 19 Q9H3P2,P98172 2 +Spastic tetraparesis 0.2926466495074511 0.2164882592055658 0.8286071759775147 1.0 1.0 24 P00846 1 +Abnormal midbrain morphology 0.3682588440213054 0.2137422198676536 0.8307480853888507 1.0 1.0 6 Q10713 1 +Headache 0.2709972347066218 0.2123641710616171 0.831822935617579 1.0 1.0 63 P53680,Q8TAA9,Q12769,P00846,P03915,O15460,P23786,Q9BW27,P00403,P25054,P06753,Q969G3 12 +Increased circulating antibody level 0.302593125015304 0.2118191957128226 0.832248092296183 1.0 1.0 17 P00813,P28070,O95394 3 +Decreased activity of mitochondrial complex iv 0.3021285600756471 0.2110530513232794 0.8328458746057807 1.0 1.0 15 Q9HA77,Q70HW3,Q9Y584 3 +Abnormal cell proliferation 0.426818530649995 0.2099466050129411 0.8337093471887456 1.0 1.0 4 O95394 1 +Abnormal forearm bone morphology 0.3019314991140048 0.2091043795171077 0.834366755919127 1.0 1.0 17 Q32P28,P98175 2 +Papilledema 0.2976855366494516 0.207372005934229 0.8357193434353654 1.0 1.0 21 P25054,Q96PZ0,Q969G3 3 +Broad phalanx of the toes 0.3654071200950802 0.2060348765619737 0.8367636681560748 1.0 1.0 6 P98172 1 +Erythroid hyperplasia 0.4247527387670941 0.2054586876026333 0.8372137720476331 1.0 1.0 4 Q9Y606 1 +Duplication involving bones of the feet 0.2996413401107614 0.2014919709630748 0.8403139069382473 1.0 1.0 15 Q10713,Q14739 2 +Motor polyneuropathy 0.3236946766342545 0.199567106196726 0.8418191556857662 1.0 1.0 11 P50336 1 +Enchondroma 0.3391032743667874 0.1992560768100126 0.8420624358092206 1.0 1.0 9 P48735 1 +Chromosomal breakage induced by ionizing radiation 0.4207955504713785 0.1970191076292305 0.8438125851111709 1.0 1.0 4 Q969G3 1 +Mania 0.3148484828852566 0.196320587930974 0.8443592480934501 1.0 1.0 12 P51812,P03915,P16615,Q92766,P00403 5 +Spastic paraparesis 0.2983922484401129 0.1960355325166009 0.8445823546135915 1.0 1.0 18 Q9Y4W6,Q9Y619,Q9NVV4,Q6DKK2,Q8WVX9 5 +Tongue atrophy 0.3739237495206861 0.192498298284316 0.8473519007578885 1.0 1.0 5 Q14331 1 +Cerebral inclusion bodies 0.3210446424653099 0.1908595616181456 0.8486356228631964 1.0 1.0 11 O96008,P22626,P09651,O15118 4 +Mutism 0.3046572716555911 0.1900896032841482 0.8492389169246513 1.0 1.0 13 P22626,P35637 2 +Polycystic liver disease 0.5434073107049555 0.1897101516951213 0.8495362653746401 1.0 1.0 3 P14314,Q9UGP8 2 +Thick lower lip vermilion 0.296493464348014 0.1875354526438624 0.8512408295531644 1.0 1.0 45 Q9Y619,P38159,P52788,P46100,Q969G3 5 +Abnormal mitochondria in muscle tissue 0.2891234604280969 0.1860958954415369 0.8523695606559643 1.0 1.0 23 Q9Y4W6,P03915,Q8N183,O00217,O43676 5 +Proximal amyotrophy 0.2952493338844532 0.1850249019476565 0.8532095038522214 1.0 1.0 15 O14979,Q13586,Q9Y6X9,Q92734,P35637,Q9BTV4,P50402 7 +Cholestasis 0.2640720627558684 0.1844105449077656 0.8536913980440031 1.0 1.0 70 P36551,O14936,O15118,O75381,P28288,Q9UBM7,Q14739,P55263,Q9Y2V7,P39210,Q16625 11 +Deviation of the thumb 0.2944004118411236 0.1819042463194204 0.8556578720165389 1.0 1.0 15 Q9UQE7,O60885,P38919,Q9Y3E5,P60953,P34897,P36776,Q9UBM7,Q14683 9 +Slow saccadic eye movements 0.3256143486367538 0.1804180568632199 0.8568243795949513 1.0 1.0 10 Q9Y4W6,P34897 2 +Paraplegia paraparesis 0.2701609790037877 0.1799196588299311 0.8572156415314798 1.0 1.0 76 P56589,Q9Y4W6,P00846,Q9Y619,P29084,Q8N183,O95831,P35637,Q6DKK2,P07942,P46100 11 +Low set posteriorly rotated ears 0.2667325079499894 0.1763010123346256 0.8600574667628245 1.0 1.0 63 Q4J6C6,Q10713,O75381,P37268,Q15392,Q9UBM7,Q9H3P2 7 +Neoplasm of the small intestine 0.3537390471410633 0.1758761260275171 0.8603912616414342 1.0 1.0 6 P78549 1 +Delayed closure of the anterior fontanelle 0.3082063385106288 0.174224149987756 0.8616893068316458 1.0 1.0 12 Q9Y487,P51812,O75381,P36543 4 +Confusion 0.2927840231860266 0.1737895318563844 0.8620308715714962 1.0 1.0 16 O96008,Q16836,P36551,Q9Y619,P11166 5 +Infantile muscular hypotonia 0.2595310543830872 0.1737564234566963 0.8620568923954988 1.0 1.0 67 P17480,P00846,P36543,P03915,P60953,O14936,O75306,O60762,Q8N3U4,Q96GM5,Q15043,Q8WXI9,P52788,Q9H2P0,O14497,Q9GZY8,P46100,Q969G3 18 +Pigmentary retinopathy 0.2955837735732313 0.1736490004158097 0.8621413202201542 1.0 1.0 42 P03915,Q8N183,P00846 3 +Difficulty standing 0.3527455529486785 0.1734123603652358 0.8623273101272384 1.0 1.0 6 P52788,Q8WVX9 2 +Increased serum lactate 0.2988014048758881 0.1731093043019079 0.8625655115908843 1.0 1.0 104 Q5U5X0,P03915,P00846,P35610,Q8N183,Q70HW3,O95831,Q8NI60 8 +Pilomatrixoma 0.5326604436677932 0.1717091770261838 0.8636661707530764 1.0 1.0 3 P25054 1 +Oromotor apraxia 0.4079204392056093 0.1710094866059268 0.8642163062454726 1.0 1.0 4 Q8N3U4,Q14683 2 +Unilateral renal agenesis 0.2922698333688036 0.1709041461687475 0.8642991364591728 1.0 1.0 17 Q9Y2V7,Q86XL3 2 +Broad neck 0.3147720235224033 0.1708620836723725 0.8643322110271838 1.0 1.0 11 P11166,Q8IY37,P78318 3 +Spastic paraplegia 0.2905202806521873 0.1701971758025456 0.8648550727002335 1.0 1.0 49 P00846,Q9Y619,Q8N183,O95831,P46100 5 +Megalocornea 0.3142117763020422 0.1691185837639882 0.865703367743613 1.0 1.0 11 Q9H3P2 1 +Hyperinsulinemic hypoglycemia 0.3369666872571045 0.1658948761729302 0.8682396798444827 1.0 1.0 7 P53985 1 +Abnormal conjunctiva morphology 0.287782464842422 0.1652593791820259 0.8687398298647719 1.0 1.0 28 P29084,P28070,P34897,Q9NSE4,Q14739 5 +Vertical supranuclear gaze palsy 0.3366778673578484 0.1651187585202101 0.8688505085034799 1.0 1.0 7 O15118 1 +Lissencephaly 0.287335946779947 0.1637770678295328 0.8699066451155857 1.0 1.0 51 Q96EK5,O00139,P11177,O00459,O14936,O95721,Q15392,P20700,Q96T60,P23786,Q86XL3,Q9Y320,P07942,Q8NAT1,Q6ZXV5,Q16625,P36543 17 +Neoplasm of the rectum 0.3048385340051938 0.1634225294599899 0.8701857653874767 1.0 1.0 12 P78549 1 +Decreased circulating cortisol level 0.3312834092287091 0.1625561195547891 0.8708679388607745 1.0 1.0 8 Q969G3 1 +Abnormal sacrum morphology 0.2859601771000946 0.162278895360986 0.871086233447014 1.0 1.0 27 P61978,Q8TAA9,Q03164,Q14739,Q9H3P2 5 +Biconcave vertebral bodies 0.3592423252775916 0.1597505959120391 0.873077542894066 1.0 1.0 5 P32322,Q14807,O00170,Q96AY3 4 +Cranial asymmetry 0.4002611818478648 0.156602137377402 0.8755584179477147 1.0 1.0 4 O96028,P40855,O14802 3 +Posterior pharyngeal cleft 0.4002251603169241 0.1565362722452142 0.8756103305141578 1.0 1.0 4 P29372 1 +Abnormal pyramidal sign 0.316450013799106 0.1561742587106281 0.8758956663212047 1.0 1.0 124 Q13217,Q9Y4W6,P00846,Q9Y619,P29084,Q92796,Q9NR77,O14773,Q15067,O95831,P34897,Q99720,P35637,Q8NI60,P41440,Q6DKK2 16 +Abnormality iris morphology 0.2640919401756086 0.1556236299904502 0.876329697836588 1.0 1.0 73 P56589,Q9NR77,P49454,Q13428,Q10713,Q9Y4I1,O75381,Q9UBM7,Q9H3P2 9 +Abnormal brain lactate level by mrs 0.3169627365813664 0.1546668056804672 0.8770840002612315 1.0 1.0 10 P00403,P03915 2 +Increased megakaryocyte count 0.5210834563250706 0.1536954336781286 0.877849885398897 1.0 1.0 3 O75533 1 +Minicore myopathy 0.5288743882544702 0.1508953969457384 0.8800582316158969 1.0 1.0 2 Q9Y281 1 +Slender build 0.2992107339258286 0.145990688266747 0.8839287393552857 1.0 1.0 12 P17252,Q15233 2 +Progressive external ophthalmoplegia 0.3139170059501031 0.1459797981695094 0.8839373362982235 1.0 1.0 10 P03915,Q5ST30 2 +Type 2 muscle fiber atrophy 0.3940581129611465 0.1455218877185762 0.8842988357871038 1.0 1.0 4 Q8TCS8,Q9NP81,Q13586 3 +Inability to walk 0.2769429265469372 0.1454680122795893 0.8843413695828364 1.0 1.0 86 P61978,P00846,Q9NR77,Q99720,P52788,P35637 6 +Ridged nail 0.3246149183986239 0.1446413451669108 0.8849940517473676 1.0 1.0 8 P98172 1 +Colon cancer 0.2903794308139057 0.142995316535968 0.8862938800450153 1.0 1.0 13 P20585,P78549 2 +Sideroblastic anemia 0.3280909971828895 0.1427497499599296 0.8864878242395178 1.0 1.0 7 Q9Y606,O75027 2 +Paraplegia 0.2828198987071814 0.1419517712156665 0.887118100802976 1.0 1.0 52 P00846,Q9Y619,Q8N183,O95831,P46100 5 +Cerebral white matter hypoplasia 0.3276660211675956 0.1416784967192641 0.887333960716665 1.0 1.0 7 P11166 1 +Chorioretinal degeneration 0.3390372157780884 0.1411307178019568 0.8877666772142598 1.0 1.0 6 Q9Y619 1 +Reduced tendon reflexes 0.3510757206984372 0.1404414488380896 0.8883112109134537 1.0 1.0 165 Q9NR77,Q15067,O95831,Q99720,P35637,P41440,P50402,P00846,Q9H173,O75381,P54802,Q96F07,P50336,Q13217,P56589,Q8TD16,Q9BQT8,Q9NSE4,Q8NAT1,P39210,P61978,P03915,P35610,P29084,Q10713 25 +Abnormal iris pigmentation 0.2840996278496331 0.1402208303304091 0.888485514273778 1.0 1.0 18 Q9Y4I1,O75381 2 +Abnormal metabolism 0.284721380781888 0.1393705613702985 0.8891573339211558 1.0 1.0 50 Q8TCJ2,Q8N511,P41440 3 +Synostosis involving bones of the hand 0.3041928041451178 0.1391484094618411 0.8893328750667742 1.0 1.0 11 Q15233,P48651 2 +Progressive distal muscle weakness 0.5108488304034667 0.138958594531742 0.8894828683107661 1.0 1.0 3 Q7Z406 1 +Upslanted palpebral fissure 0.267362844027979 0.1369813103236435 0.8910455680456455 1.0 1.0 78 P56589,Q14004,P60953,Q92796,Q13868,O75381,Q9UM00,Q15233,Q00577,Q8WXI9,Q86XL3,P52788,Q9NVI7,Q9UBM7,P46100 15 +Suicidal ideation 0.5086353924290997 0.1359173785919976 0.8918865968379 1.0 1.0 3 Q14203 1 +Abnormality of the parathyroid gland 0.279426006701384 0.1340685920607483 0.8933483352919278 1.0 1.0 22 P48735 1 +Abnormality of the nasal tip 0.2901496758097637 0.1338819332608735 0.8934959368268143 1.0 1.0 100 Q14696,P60953,O14936,O95831,Q00577,P23786,P98172,Q969G3,P25054,O14497,Q9Y2V7,O75844,P42892,P46100,P36543,Q96EK5,Q03164,Q8WXI9,P52788,P61978,Q92796,P38159,P17252,Q96GM5 24 +Accelerated skeletal maturation 0.309370553393456 0.1333866975477624 0.8938875652183993 1.0 1.0 10 P10412 1 +Erythroderma 0.3155191706671226 0.132086395693707 0.8949159562911801 1.0 1.0 9 P00813 1 +Abnormality of the diencephalon 0.2839186043744273 0.13069922431453 0.8960132459887202 1.0 1.0 31 P11166,Q96KP1,Q9UPT5,Q96EY7,Q9GZY8,Q8N3U4,Q969G3 7 +Genital neoplasm 0.2846048585274244 0.129677093655784 0.8968219061327718 1.0 1.0 32 Q13423,Q92878,P49959,P20585,Q8IY37,P25054,P48735,P78549 8 +Abnormal elasticity of skin 0.2695877072659119 0.1285139246746413 0.8977422793017633 1.0 1.0 59 O75844,Q13126 2 +Abnormal cutaneous elastic fiber morphology 0.5028431498482255 0.1282029381015663 0.8979883749902264 1.0 1.0 3 P36543 1 +Prominent veins on trunk 0.5028431498482255 0.1282029381015663 0.8979883749902264 1.0 1.0 3 P36543 1 +Abnormal circulating apolipoprotein concentration 0.5028431498482255 0.1282029381015663 0.8979883749902264 1.0 1.0 3 P36543 1 +Abnormal subcutaneous fat tissue distribution 0.5028431498482256 0.1282029381015663 0.8979883749902264 1.0 1.0 3 P36543 1 +Abnormality of metacarpophalangeal joint 0.3831337205865439 0.127291310982104 0.898709837197166 1.0 1.0 4 O60828,Q15233 2 +Tall stature 0.2814775413843524 0.1255543517315796 0.9000846989529392 1.0 1.0 51 P61978,Q13423,Q9Y296,Q9H3P2,Q15233,P17252,P52788,Q9NWM8,Q96PZ0,P36543 10 +Focal segmental glomerulosclerosis 0.2793315828442098 0.1249643641214186 0.9005517624501032 1.0 1.0 20 P03915,Q12769,P00403,Q9BW27,Q8NFH4,Q14C86 6 +Aplasia hypoplasia involving bones of the lower limbs 0.2658875737640418 0.1245922220303334 0.900846386335195 1.0 1.0 78 Q9NX62,Q9Y619,Q9H173,P00813,O95831,Q96HY6,Q9UBM7,Q9H3P2 8 +Abnormal heart rate variability 0.3812008512219287 0.1242360173134843 0.9011284054406457 1.0 1.0 4 Q8N3U4,Q14683 2 +Paraparesis 0.2734003846540955 0.1242016802487883 0.901155591895344 1.0 1.0 24 Q6DKK2,Q9Y619,P35637 3 +Nephrotic syndrome 0.2750950423008555 0.1228326345410218 0.902239631306833 1.0 1.0 23 Q12769,O95721,P00813,Q9BW27,Q8IY37 5 +Hypoplasia of teeth 0.2777613621870889 0.1221483162112805 0.9027815575305524 1.0 1.0 21 Q9Y2V7,O75844 2 +Thyroid carcinoma 0.2765906155772109 0.1212696744457781 0.9034774389995932 1.0 1.0 15 O14497,Q969G3,P25054 3 +Elevated urinary monocarboxylic acid level 0.4964099216710104 0.1200457425101391 0.9044469126520868 1.0 1.0 3 P51649,O96000 2 +Joint stiffness 0.2768182465019483 0.1199116248992177 0.9045531555872266 1.0 1.0 54 O15460,O75844,P48735,P46100 4 +Intestinal malrotation 0.2736347624684369 0.1180959209208456 0.9059916554697436 1.0 1.0 25 P49454,Q15392,Q14739 3 +Abnormal muscle fiber alpha dystroglycan 0.5044045676998232 0.1179922940364191 0.9060737636984764 1.0 1.0 2 Q14118 1 +Calf muscle pseudohypertrophy 0.5044045676998232 0.1179922940364191 0.9060737636984764 1.0 1.0 2 Q14118 1 +Congenital muscular dystrophy 0.5044045676998188 0.1179922940364137 0.9060737636984806 1.0 1.0 2 P02545 1 +Genetic anticipation 0.5011419249591987 0.1141374686306055 0.9091288206174712 1.0 1.0 2 P54886 1 +Mild hearing impairment 0.287989625335535 0.1136022139252861 0.9095531322567318 1.0 1.0 12 Q96GW9,Q92796 2 +Phenotypic variability 0.2907319330950757 0.113379325445759 0.909729829914262 1.0 1.0 103 P36551,Q9NR77,Q13868,Q00577,P50995,Q92733,Q969G3,O14979,P00846,Q9Y4W6,Q9H061,Q8TD16,Q9NTZ6,Q8NI60,P06753,P03915,Q70HW3,P49959,O00217,P00403 20 +Abnormal blood gas level 0.4903847859900179 0.1127940407673013 0.9101938429717762 1.0 1.0 3 P06753 1 +Bladder neoplasm 0.3154979487441463 0.1124672575645499 0.9104529296767438 1.0 1.0 7 P78549 1 +Abnormality of the metacarpal bones 0.2834747102339124 0.1108622624610493 0.9117255712736628 1.0 1.0 36 Q9NX62,Q9H173,Q15233,Q32P28,Q9UBM7,Q14739 6 +Stereotypical hand wringing 0.3722389205848576 0.110735474250922 0.9118261145765992 1.0 1.0 4 P20700 1 +Recurrent bronchitis 0.3331156107119516 0.1099135386596359 0.912477945303612 1.0 1.0 5 O60934,Q03519,Q05655,Q9H0U3 4 +Impaired collagen induced platelet aggregation 0.4959216965742148 0.1082221328501742 0.9138194885882848 1.0 1.0 2 Q8N5K1 1 +Diffuse mesangial sclerosis 0.2721601235297961 0.1076655687020915 0.9142609828981616 1.0 1.0 15 Q12769,P00813,Q9BW27,Q14C86,Q8NFH4 5 +Aplasia hypoplasia of the eyebrow 0.2837576324411778 0.1074916448372129 0.914398953373174 1.0 1.0 43 Q96EK5,P61978,Q14696,P60953,P00813,Q9UM00,Q8WVM7,Q00577,P52788,Q9Y2V7,O75844 11 +Aplasia hypoplasia of toe 0.2798860661106009 0.1069879552498894 0.914798535224927 1.0 1.0 32 Q9NX62,Q03164,P00813,Q9H3P2,Q9UBM7,P25054,Q96PZ0 7 +Upper limb undergrowth 0.2725669632741321 0.1048772941732101 0.916473176215352 1.0 1.0 16 P98175,Q14739,P25054 3 +Flat face 0.2719640052822237 0.1040230905614171 0.9171510243567508 1.0 1.0 26 Q9NX62,P56589,Q03164,O75381,P46100 5 +Abnormal right ventricle morphology 0.311697755139425 0.1039298312274511 0.9172250333964952 1.0 1.0 7 Q15233 1 +Abnormal peripheral nervous system morphology 0.3390707987084073 0.1032481430981803 0.9177660313812844 1.0 1.0 156 Q9NR77,Q15067,O95831,Q99720,P35637,P41440,Q6DKK2,Q969G3,Q9Y4W6,P00846,O75381,Q9GZY8,P46100,P56589,Q9Y619,P48651,Q9BQT8,P39210,P03915,Q92796 20 +Solitary median maxillary central incisor 0.4785299782407259 0.099602026238917 0.9206602851213248 1.0 1.0 3 Q8N3U4 1 +Generalized aminoaciduria 0.4778067885117419 0.0988426937962273 0.9212631697006172 1.0 1.0 3 P38117,Q16134 2 +Abnormal cranial nerve physiology 0.2539992281872542 0.0987469868220068 0.921339161057486 1.0 1.0 70 P56589,P48651,Q9NR77,Q92796,O75381,P48735,Q969G3 7 +Abnormal adipose tissue morphology 0.2687788788540181 0.0970824081642982 0.9226609511148632 1.0 1.0 57 P53680,P03915,P29084,Q9BTV4,P28070,P17252,P25054,O75844,P50402,P36543 10 +Abnormal tracheal morphology 0.2767089099826018 0.0967773071827013 0.9229032455725684 1.0 1.0 31 Q13428,Q96HY6,Q14739 3 +Glomerulonephritis 0.2705850012591317 0.095617700551275 0.9238242066072316 1.0 1.0 17 Q12769,O95394,Q9BW27,Q8NFH4,Q14C86,Q03252 6 +Subcortical band heterotopia 0.3608407311447644 0.0951309569059171 0.9242108095177326 1.0 1.0 4 P07942 1 +Subcortical heterotopia 0.3608407311447644 0.0951309569059171 0.9242108095177326 1.0 1.0 4 P07942 1 +Skin ulcer 0.2725261543217577 0.0940526249500156 0.9250673533022872 1.0 1.0 28 O15460,P48735,Q14739 3 +Aphasia 0.2797913466925742 0.0927693930053776 0.9260867669668768 1.0 1.0 36 P03915,Q13428,Q9Y296,P09651,P22626,Q96PZ0,P46100 7 +Repetitive compulsive behavior 0.4805872756932917 0.0925896172329766 0.9262295925612504 1.0 1.0 2 P51608 1 +Color vision defect 0.2695050869936585 0.09226453170317 0.92648786773392 1.0 1.0 17 Q6P4Q7,Q9H061 2 +Otosclerosis 0.4799347471451731 0.0919804152750388 0.926713599965616 1.0 1.0 2 Q12830 1 +Abnormality of the stapes 0.4799347471451731 0.0919804152750388 0.926713599965616 1.0 1.0 2 Q12830 1 +Abnormality of the middle ear ossicles 0.4799347471451731 0.0919804152750388 0.926713599965616 1.0 1.0 2 Q12830 1 +Subcapsular cataract 0.3217864425601098 0.0916960891724405 0.9269395046906506 1.0 1.0 5 Q8N2K0,Q9H6K4 2 +Coarse hair 0.2691834010418494 0.0912731252261068 0.9272755717983936 1.0 1.0 17 Q9Y276,P51812,P36543,Q9UM00,P54802,P15586 6 +Progressive visual field defects 0.4789559543229886 0.0910749611585684 0.9274330280424516 1.0 1.0 2 P35222 1 +Deep palmar crease 0.2787717157294046 0.0894145112037542 0.9287524913912126 1.0 1.0 12 P61978 1 +Abnormality of amino acid metabolism 0.476998368678618 0.0892939280748463 0.9288483194891644 1.0 1.0 2 P19447 1 +Anophthalmia 0.2917381361705918 0.0888896265895886 0.9291696276992474 1.0 1.0 10 Q8NAT1 1 +Dementia 0.2763747194869345 0.0879981768636137 0.9298781251745714 1.0 1.0 50 P00846,P03915,O15118,Q8WVX9,P09651,P27544,P35637,P22626,P36543 9 +Skin dimple 0.267799094084808 0.0879332405537052 0.9299297367824562 1.0 1.0 22 Q03164,Q8TAA9,Q9H3P2,P61978 4 +Chronic fatigue 0.3190725016329173 0.0876340971026639 0.9301675008537926 1.0 1.0 5 P04637,Q9NZJ7,Q13423,P07602 4 +Pseudoepiphyses 0.4656331541581769 0.0868247264526761 0.9308108329726672 1.0 1.0 3 P51812 1 +Pseudoepiphyses of the metacarpals 0.4656331541581769 0.0868247264526761 0.9308108329726672 1.0 1.0 3 P51812 1 +Pseudoepiphyses of hand bones 0.4656331541581769 0.0868247264526761 0.9308108329726672 1.0 1.0 3 P51812 1 +Neoplasm of the nervous system 0.2790660464278983 0.085149262743419 0.9321427264779664 1.0 1.0 45 P48735,P78549,P46100,Q969G3 4 +Axonal degeneration regeneration 0.3503571628524353 0.0822942542125274 0.9344127233983726 1.0 1.0 4 P02545,P51149 2 +Absent nipple 0.46818923327895 0.0817621482698951 0.934835856560056 1.0 1.0 2 P10586 1 +Hypoplastic vertebral bodies 0.3085869492687347 0.0811690111893278 0.935307543663472 1.0 1.0 6 Q14739 1 +Vomiting 0.2815532011181397 0.0804635329501782 0.9358685986512092 1.0 1.0 98 P50336,P61978,P03915,P00846,P35610,Q9Y619,P36551,Q8N183,P22695,P23786,O43676,P39210,P46100 13 +Abnormal growth hormone level 0.2718680240760572 0.0802289284512917 0.9360551827369874 1.0 1.0 30 Q4J6C6,Q03164,Q96GW9,Q9NSE4,Q969G3 5 +Eeg with focal spikes 0.4578981723237652 0.0799192892117111 0.9363014483271735 1.0 1.0 3 P36776,P08559 2 +Abnormal circulating nitrogen compound concentration 0.2757022969321793 0.0791775240356348 0.9368914216786348 1.0 1.0 49 Q9Y619,P23786,O43772,P35610 4 +Reduced forced expiratory volume in one second 0.4649265905383258 0.0791679415360656 0.9368990434816652 1.0 1.0 2 O95453 1 +Abnormal protein glycosylation 0.265758495857857 0.0783081613634648 0.9375829255716436 1.0 1.0 18 Q9Y2V7,Q8N511 2 +Lymphopenia 0.2685528092022192 0.0771186471503946 0.93852915889494 1.0 1.0 28 P00813,P28070,O95394,Q96MG7 4 +Abnormality of the upper arm 0.2656686838753845 0.076507961808452 0.9390149799360492 1.0 1.0 19 O14979,P48651,Q9Y6X9,Q8WXH0,P36776,P02545,Q9BTV4,P50402 8 +Cerebral palsy 0.2798535858854734 0.0762450864605345 0.9392241132501876 1.0 1.0 11 P48735,P98175 2 +Lower limb muscle weakness 0.2776622816912725 0.0760051400271371 0.9394150088790204 1.0 1.0 44 Q9NR77,P00846 2 +Abnormality on pulmonary function testing 0.2655487236777799 0.0758242155815486 0.9395589503324184 1.0 1.0 20 Q9BQT8 1 +Premature skin wrinkling 0.2653118404779391 0.0753749232454993 0.9399164107907458 1.0 1.0 19 O75844 1 +Metamorphopsia 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Uveal melanoma 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Abnormal ciliary body morphology 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Choroidal melanoma 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Inferior lens subluxation 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Photopsia 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Lens subluxation 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Mydriasis 0.450391644908616 0.0737401992876438 0.9412171114379072 1.0 1.0 3 O75533,P29992 2 +Abnormal urine magnesium concentration 0.4561174551386533 0.0726691870063453 0.9420693689060052 1.0 1.0 2 P29992 1 +Abnormality of complement system 0.3403891542568599 0.0713941178108993 0.9430840909721788 1.0 1.0 4 Q03252 1 +Limited elbow movement 0.272759946095535 0.0703740247214331 0.943895965247424 1.0 1.0 33 P48651,P37268,Q8WVM7,P23786,Q9BTV4,P50402 6 +Dilated third ventricle 0.4518760195758472 0.0697940581334451 0.9443575765691096 1.0 1.0 2 Q93009 1 +Delirium 0.4518760195758468 0.0697940581334448 0.94435757656911 1.0 1.0 2 Q9UJS0 1 +Ectropion of lower eyelids 0.450244698205538 0.0687306997161679 0.9452039811376038 1.0 1.0 2 O60716 1 +Abnormal erythrocyte enzyme level 0.2622848077221104 0.0678676688677616 0.9458909758964642 1.0 1.0 18 P61313,P00813,Q07020 3 +Retinal atrophy 0.2614959635485421 0.0675530834923739 0.9461414039828222 1.0 1.0 25 Q10713,P04439,Q96PZ0 3 +Progressive proximal muscle weakness 0.447960848287106 0.0672808411523639 0.9463581288696206 1.0 1.0 2 Q15149 1 +Annular pancreas 0.440926892950385 0.0666538432165145 0.9468572803248084 1.0 1.0 3 Q96T58,Q9Y4R8 2 +Mortality aging 0.2817720689973224 0.0661121577406761 0.947288531551966 1.0 1.0 100 Q9Y2V7,Q8TCJ2,O75718,Q15067,O75381,Q14739,O75844,P46100 8 +Trigonocephaly 0.2542757421565185 0.0649478503694746 0.9482155219046078 1.0 1.0 14 O60762,Q02809,P20700,Q92785,Q9H2P0,Q03252 6 +Germinoma 0.4430668841761784 0.0643232154784136 0.9487128684511444 1.0 1.0 2 P35222 1 +Central primitive neuroectodermal tumor 0.4430668841761764 0.0643232154784122 0.9487128684511454 1.0 1.0 2 P04637 1 +Psoriasiform dermatitis 0.333006856023508 0.0641126693008325 0.9488805139582746 1.0 1.0 4 P10321,P01889,Q15800 3 +Clubbing of toes 0.4407830342577444 0.0630109093375809 0.9497578171903522 1.0 1.0 2 Q9NVI1 1 +Pyridoxine responsive sideroblastic anemia 0.4407830342577444 0.0630109093375809 0.9497578171903522 1.0 1.0 2 Q9NVI1 1 +Duodenal stenosis 0.4407830342577444 0.0630109093375809 0.9497578171903522 1.0 1.0 2 Q9NVI1 1 +Aplasia involving bones of the extremities 0.4407830342577403 0.0630109093375787 0.949757817190354 1.0 1.0 2 P02545 1 +Aplasia of the phalanges of the hand 0.4407830342577403 0.0630109093375787 0.949757817190354 1.0 1.0 2 P02545 1 +Prolonged partial thromboplastin time 0.2971130269783112 0.0628105800886904 0.94991734081405 1.0 1.0 6 P28288 1 +Hypoplastic labia majora 0.2845472132529188 0.0612864502935104 0.95113108161662 1.0 1.0 9 P16435,O60885,Q9UQE7,Q9Y619 4 +Abnormal labia majora morphology 0.2845472132529188 0.0612864502935104 0.95113108161662 1.0 1.0 9 P16435,O60885,Q9UQE7,Q9Y619 4 +Carcinoma 0.2953283240771011 0.0601602812569415 0.9520279793534984 1.0 1.0 6 P51532,P43246,Q07864,P28340,P25054 5 +Abnormality of the ureter 0.261225934923368 0.0579978168487607 0.9537503675036834 1.0 1.0 58 P61978,O14936,Q86XL3,P23786,O75844,P46100 6 +Neonatal hypotonia 0.2710788994879187 0.0574594101285157 0.9541792386857972 1.0 1.0 50 P56589,P10412,Q16836,Q9Y584,O14936,Q15067,Q9UM00,Q15233,Q00577,Q8WXI9,P23786 11 +Non midline cleft lip 0.3251714005876617 0.0570920883412464 0.9544718387343324 1.0 1.0 4 O60934,O60716,Q9NXE4 3 +Chest pain 0.2582050129009874 0.0561373564127922 0.9552323847325048 1.0 1.0 18 P50336,Q9BTV4 2 +Premature birth 0.273751714532232 0.055550136007328 0.9557001888229816 1.0 1.0 41 O75844,O43676,O75381,Q9UBM7 4 +Peritonitis 0.2641134047580288 0.0555215670848132 0.955722948400203 1.0 1.0 12 O43707,Q12769,Q9BW27,Q8NFH4,Q14C86 5 +Minimal change glomerulonephritis 0.2641134047580288 0.0555215670848132 0.955722948400203 1.0 1.0 12 O43707,Q12769,Q9BW27,Q8NFH4,Q14C86 5 +Aplasia hypoplasia of the gallbladder 0.421207177814026 0.0534065220450089 0.9574080087905454 1.0 1.0 2 P18583 1 +Aplasia hypoplasia of the phalanges of the toes 0.4179445350734042 0.0520707056568338 0.958472354788585 1.0 1.0 2 P02545 1 +Intractable diarrhea 0.3174523887096451 0.0508589121512847 0.9594379464655596 1.0 1.0 4 Q15477 1 +Neoplasm of the larynx 0.4148172323759808 0.0508567362593655 0.9594396803323382 1.0 1.0 3 P52701,P04637 2 +Abnormality of mouth shape 0.2525320321494078 0.0499477190153134 0.960164050458032 1.0 1.0 62 P61978,Q10713,Q15233,Q00577,Q96PZ0,Q86XL3,Q8IY37,Q9H3P2,P46100 9 +Combined immunodeficiency 0.2779398529174484 0.0488237315496744 0.9610597696828777 1.0 1.0 9 P00813 1 +Muscular dystrophy 0.2613367471099435 0.0481491958332367 0.9615973390391332 1.0 1.0 28 O14979,Q9H173,Q8WXH0,O60762,Q9BTV4,Q14331,P09651,P22626,Q8NAT1,P50402 10 +Coarse facial features 0.2454448356664681 0.047221696908635 0.9623365351771112 1.0 1.0 65 P38159,O95831,P54802,P46100,Q969G3 5 +Equinus calcaneus 0.4042414355627985 0.0471897840434092 0.9623619696049616 1.0 1.0 2 P40939 1 +Eeg with focal sharp waves 0.4050261096605805 0.0462129543972793 0.9631405173908034 1.0 1.0 3 P36776,P08559 2 +Chills 0.4043733681462186 0.0459259088322885 0.9633693036985288 1.0 1.0 3 P11171,P40939 2 +Rieger anomaly 0.3999999999999972 0.0458996333964777 0.9633902463780516 1.0 1.0 2 O96028 1 +Malrotation of small bowel 0.3999999999999972 0.0458996333964777 0.9633902463780516 1.0 1.0 2 O96028 1 +Ectopia pupillae 0.3999999999999972 0.0458996333964777 0.9633902463780516 1.0 1.0 2 O96028 1 +Craniofacial asymmetry 0.3999999999999972 0.0458996333964777 0.9633902463780516 1.0 1.0 2 O96028 1 +Preaxial foot polydactyly 0.3999999999999972 0.0458996333964777 0.9633902463780516 1.0 1.0 2 O96028 1 +Myoclonus 0.2687036015917761 0.0453345987985236 0.9638406099246928 1.0 1.0 90 O14936,Q96AA3,Q00577,Q969G3,Q9Y4W6,P00846,O95394,Q9HA77,O14773,Q96F07,P27544,P52788,Q8NI60,P03915,Q10713,P49959,P00403,Q96EY7,Q01105 19 +Duplication of hand bones 0.267664981165306 0.0431278185193168 0.9655996439531872 1.0 1.0 51 P61313,O00459,Q10713,Q15067,P34897,Q9UBM7,Q14739,Q9H3P2,P98172,P98175 10 +Delayed ossification of carpal bones 0.3892332789559506 0.0430417783766433 0.9656682303665882 1.0 1.0 2 P36776 1 +Buphthalmos 0.3859706362153292 0.04228496423097 0.9662715313713568 1.0 1.0 2 Q14118 1 +Joint laxity 0.246745025095244 0.0420790571228489 0.966435675376096 1.0 1.0 70 P61978,P36543,Q9Y619,P49959,Q8WVM7,Q15233,Q32P28,Q8WXI9,Q96HY6,P55795,O14497,P98172,Q969G3 13 +Abnormal electroretinogram 0.2625054916636055 0.0417320609745977 0.9667122952546476 1.0 1.0 30 Q15067,P00846 2 +Decreased circulating androgen concentration 0.25715206406358 0.0413898934771054 0.9669850697313156 1.0 1.0 12 Q969G3 1 +Short thorax 0.3893611136030799 0.0400452569299668 0.9680570453976116 1.0 1.0 3 P11166 1 +Limitation of neck motion 0.3838120104438667 0.0381984479756295 0.969529458330458 1.0 1.0 3 P02545,Q8TD19 2 +Verrucae 0.3803706811507744 0.0371347647064989 0.9703775529081422 1.0 1.0 3 Q8IWT6 1 +Abnormality of t cell physiology 0.2469903313651867 0.0362571394644494 0.9710773252036508 1.0 1.0 16 Q9Y2V7,P00813,O95394 3 +Abnormal glomerular mesangium morphology 0.2469398555391766 0.0361425624409924 0.9711686845620392 1.0 1.0 16 Q12769,P00813,Q9BW27,Q14C86,Q8NFH4 5 +Abnormality of body mass index 0.3769582245430796 0.0361390013204662 0.9711715240701002 1.0 1.0 3 P42858,Q9UJS0 2 +Rigidity 0.2653980734980598 0.035622363541975 0.9715834761087984 1.0 1.0 52 P00846,Q9H173,O14936,Q9Y4I1,Q15392,Q96F07 6 +Atrial flutter 0.3373572593800972 0.0354925016773858 0.9716870254045302 1.0 1.0 2 P02545 1 +Aplasia hypoplasia of the epiglottis 0.3249592169657396 0.0347009174986122 0.9723182293112752 1.0 1.0 2 P38919 1 +Sunken cheeks 0.3230016313213695 0.0345985517956821 0.9723998563095976 1.0 1.0 2 Q07954 1 +Weakness of the intrinsic hand muscles 0.2897226753670499 0.0335237329235983 0.9732569403299252 1.0 1.0 2 Q13586 1 +Hyperorality 0.289722675367051 0.0335237329235983 0.9732569403299252 1.0 1.0 2 Q14203 1 +Neoplasm of the oral cavity 0.2584058668713545 0.0327595672641431 0.9738663215420612 1.0 1.0 11 Q969G3 1 +Constipation 0.2606128390540445 0.0323079052603398 0.974226505011074 1.0 1.0 84 P50336,P61978,Q8TAA9,P03915,P36551,Q13423,Q03164,P37268,P78318,Q8WXI9,P00403,Q9UBM7,P25054,P42892,P46100,Q8WVX9 16 +Abnormal brain choline level by mrs 0.3580287206266372 0.0315821239201724 0.9748052993237036 1.0 1.0 3 P09543,P07602 2 +Abnormal brain n acetyl aspartate level by mrs 0.3580287206266372 0.0315821239201724 0.9748052993237036 1.0 1.0 3 P09543,P07602 2 +Reduced brain n acetyl aspartate level by mrs 0.3580287206266372 0.0315821239201724 0.9748052993237036 1.0 1.0 3 P09543,P07602 2 +Abducens palsy 0.3580287206266321 0.0315821239201713 0.9748052993237046 1.0 1.0 3 O00170,P07602 2 +Prominent nasal bridge 0.2680090208846387 0.0313335870562123 0.9750035049536552 1.0 1.0 47 O14936,P49454,Q10713,Q8WVM7,P52788,P42892 6 +Lipodystrophy 0.2621653849114846 0.0307210473033954 0.9754920057625724 1.0 1.0 32 O75844,P28070,P50402,P36543 4 +Brain imaging abnormality 0.2637622551239655 0.0286184013871172 0.9771689359102188 1.0 1.0 34 P03915,P35610,P60953,Q00577,P00403,Q969G3 6 +Pelvic girdle muscle weakness 0.267734553775737 0.0281113800635848 0.977573317683088 1.0 1.0 8 Q9Y223,P55072,O14979,Q15149,Q9Y5L0,A6NHR9,P06753 7 +Periorbital fullness 0.2494836483332828 0.0273537322828785 0.9781776007152768 1.0 1.0 20 P38159 1 +Abnormality of the extraocular muscles 0.3273498694517018 0.0269785321259031 0.9784768566803452 1.0 1.0 3 Q13509,P43243 2 +Neoplasm of the skin 0.2676971299469357 0.0265594233890527 0.978811137277782 1.0 1.0 42 Q969G3,Q06136,P29084,P20585,Q15126,P25054,P78549 7 +Peripheral hypomyelination 0.3221279373368193 0.0264560375775848 0.9788935982444298 1.0 1.0 3 Q8TB36,O60231 2 +Mastoiditis 0.3198433420365635 0.026246673133603 0.9790605889128396 1.0 1.0 3 O60934,Q15043 2 +Abnormality of the mastoid 0.3198433420365635 0.026246673133603 0.9790605889128396 1.0 1.0 3 O60934,Q15043 2 +Increased urinary non proteinogenic amino acid level 0.2699967352269082 0.0253300870995104 0.9797916755909408 1.0 1.0 4 P51649,P32929,O00469 3 +Increased serum iron 0.3054830287206369 0.0251659221316161 0.979922618541889 1.0 1.0 3 Q9Y276,Q02241 2 +Dry hair 0.3043588589600906 0.0250966335336773 0.9799778853889084 1.0 1.0 3 Q9Y276 1 +Abnormal phalangeal joint morphology of the hand 0.2618013883312979 0.024933138509281 0.980108294736646 1.0 1.0 33 O75844,P98172 2 +Conjugated hyperbilirubinemia 0.2677113940581205 0.0245648359546916 0.9804020676734402 1.0 1.0 4 P11166,Q9H267,Q86SX6 3 +Hypoplastic toenails 0.2486112361605866 0.0234216017800262 0.9813139740027288 1.0 1.0 22 Q969G3,P23786,Q92785,O14497,Q96GM5 5 +Abnormality of the cerebrospinal fluid 0.3174111960518113 0.0227099882631193 0.9818816084095456 1.0 1.0 143 P00846,P03915,O00459,Q9NR77,Q8N183,P49454,Q10713,P07237,Q15392,O95831,P23786,Q8NI60,Q9Y2V7,P07942,P39210,O43676,Q16625,Q969G3 18 +Epiphora 0.2533463924257333 0.0205093920414505 0.9836370198875128 1.0 1.0 4 O60832,Q07954,Q15043 3 +Abnormality of the bladder 0.2835079243852196 0.0182736112612448 0.9854205791142552 1.0 1.0 108 P50336,P61978,Q9NR77,Q99720,Q86XL3,P35637,Q9NWM8,P46100,Q969G3 9 +Multifocal seizures 0.2593923554394014 0.017941210032676 0.9856857534452808 1.0 1.0 6 Q6PJG6,Q9HA77,Q96S52,Q9UGM6,Q14683 5 +Dysmetria 0.2588897834715276 0.0173769318344629 0.9861359121068234 1.0 1.0 55 Q5JRX3,Q9Y4W6,Q10713,O14773,Q8N183,Q96GW9,P41440,Q6DKK2 8 +Posterior subcapsular cataract 0.2347371857655961 0.0168895510462638 0.9865247286367732 1.0 1.0 4 P36405,Q9H6K4,O43837 3 +Bone pain 0.2454664774919179 0.0167358932023452 0.986647312531488 1.0 1.0 20 P48735,Q6UN15 2 +Sepsis 0.2473155078654901 0.0166152554059562 0.9867435541844992 1.0 1.0 25 P42892,O95394,P00813,P25054 4 +Nephritis 0.2452511342177185 0.0161836394960309 0.9870878875466096 1.0 1.0 20 O43707,Q12769,O95394,Q8N1F7,Q9BW27,Q14C86,Q8NFH4,Q03252 8 +Dilated fourth ventricle 0.2647534539622752 0.0158929946057441 0.987319758792668 1.0 1.0 40 P36543,P60953,O14936,Q10713,Q8WVX9,Q96GM5,P49959,P23786,Q9UBM7,O14497,Q8NAT1,Q969G3 12 +Speech articulation difficulties 0.2236546261412951 0.0154195295396285 0.987697482959038 1.0 1.0 4 Q8N3U4 1 +Poor wound healing 0.2364467668190721 0.0135479961603819 0.9891905937093376 1.0 1.0 5 P04062,Q02809,O00170,O15270 4 +Esophageal stenosis 0.2535119242077756 0.0129131359329356 0.9896970945416914 1.0 1.0 6 O95394,P06748,O60832,O95453,P01889 5 +Renal agenesis 0.2625037996158618 0.0116021892243537 0.9907430000288612 1.0 1.0 50 Q15392,Q86XL3,Q9UBM7,Q9Y2V7,P46100 5 +Retinal detachment 0.2309691874451654 0.0103763239792592 0.991721039862644 1.0 1.0 15 Q8NAT1,Q02809,P04439,Q14331 4 +Abnormal blood glucose concentration 0.2711863876525391 0.0100480050136257 0.9919829868358064 1.0 1.0 97 P35610,Q4J6C6,Q8N183,P22695,O43772,P23786,O75844,P53985,O43676 9 +Nasogastric tube feeding 0.2450904123726559 0.0094351178420742 0.992471976837207 1.0 1.0 25 Q96EY7,Q9GZY8,Q96N66,Q15233 4 +Abnormality of the testis size 0.2520211192973536 0.0087001458895859 0.9930583754896074 1.0 1.0 29 P46100 1 +Ectopic calcification 0.2532215345111321 0.0082263652999578 0.993436384165746 1.0 1.0 58 P03915,Q9Y4I1,O75381,P23786,Q14739,Q9UBM7,O75844,Q16625 8 +Finger syndactyly 0.2516998602911361 0.0076056115283716 0.993931658490304 1.0 1.0 29 Q9Y619,P48651,Q9UBM7,P25054,P98172,P98175 6 +Pace of progression 0.3257520005312996 0.0058883028370528 0.9953018412261794 1.0 1.0 155 Q5U5X0,Q9Y4W6,Q9NR77,Q8N183,Q13126,Q10713,O14773,Q9NR28,O95831,Q99720,P27544,P54802,P28288,P41440,P55263,P07942,P39210,P50402 18 +Microvesicular hepatic steatosis 0.2454900090033006 0.0054790057361672 0.9956284077867444 1.0 1.0 10 Q9HA77,P39210 2 +Simplified gyral pattern 0.2492590261176067 0.0049480884497259 0.9960520127306264 1.0 1.0 28 O14936,Q96GM5,P20700,Q86XL3,Q9UPT5,O14497,Q03252,Q969G3 8 +Gonosomal inheritance 0.240494793787518 0.0046793577186544 0.9962664263471136 1.0 1.0 69 Q92796,O14936,P38159,O95831,Q15233,P52788,P98172,P46100 8 +Abnormal mitral valve physiology 0.2548339653839084 0.0034836823717913 0.9972204292429728 1.0 1.0 32 O75844 1 +Hip contracture 0.2389590375420086 0.0027636857728488 0.9977949005980102 1.0 1.0 11 Q8TD16 1 +Abnormal bone structure 0.3312910053495001 0.0024951258802449 0.998009179648586 1.0 1.0 162 O75718,P07237,Q13126,O95831,Q9UBM7,Q13428,O75381,Q32P28,Q96HY6,P54802,Q14739,Q8IY37,O75844,Q9H3P2,P56589,Q9Y619,P48651,Q15392,Q86XL3,P52788,Q9NSE4,P48735,P61978,P29084,Q9NWM8 25 +Abnormality of the diaphragm 0.24100014054027 0.0019473269752218 0.9984462588536214 1.0 1.0 22 Q9H3P2,P98172 2 +Abnormality of the synovia 0.2475985175911814 0.0006661365664783 0.9994684999575284 1.0 1.0 76 O75718,Q9H173,Q8TD16,Q9NSE4,Q9UBM7,O75844,P36543 7 +Abnormal systemic blood pressure 0.2646257094609481 0.0003610870566315 0.9997118942186688 1.0 1.0 92 P50336,P03915,O43772,O75844,P42892,P46100 6 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f6f3776f8a7a80d285310dc9b5dc09329e31259d --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal bowel sounds", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal coccyx morphology", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger flexion creases", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemidiaphragm morphology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal right ventricular function", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical adenoma", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid nose", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Chin with horizontal crease", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Choroideremia", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic myelogenous leukemia", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Compensatory head posture", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crossed fused renal ectopia", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystathioninemia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum complement c4", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Eeg with spike wave complexes 2 5 3 5 hz", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg myotonic discharges", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal ulceration", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Folliculitis", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu recurvatum", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonadotropin deficiency", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematemesis", "Hematochezia", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemophagocytosis", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensibility of the knee", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermagnesiuria", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the fundus", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypoglycorrhachia", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Imbalanced hemoglobin synthesis", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Inappropriate sexual behavior", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal bleeding", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular acetabular roof", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "Ivory epiphyses", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited knee extension", "Limited wrist extension", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low plasma citrulline", "Low posterior hairline", "Low self esteem", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Miosis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic absence seizure", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuroma", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid dysgenesis", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dyskinesia", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Personality disorder", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postprandial hyperglycemia", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent coccyx", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protracted diarrhea", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged fingernail", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe b lymphocytopenia", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Silver gray hair", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowed slurred speech", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue neoplasm", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tibialis muscle weakness", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Uncontrolled eye movements", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zollinger ellison syndrome", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ANAPC1", "ANAPC2", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANXA11", "AP1B1", "AP1S2", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APPL1", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6IP1", "ARPC1B", "ARVCF", "ASAH1", "ASCC1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATG7", "ATIC", "ATP1A1", "ATP2A2", "ATP5A1", "ATP6", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "ATR", "ATRX", "ATXN10", "B4GAT1", "BAG3", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCKDHA", "BCKDK", "BCR", "BCS1L", "BICD2", "BLVRA", "BMS1", "BPTF", "BRAT1", "BRD4", "BUB1B", "BUB3", "C19orf70", "C1QBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAPN1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CCDC22", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC42", "CDC73", "CDH2", "CDK13", "CDK4", "CELF2", "CENPF", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD3", "CHD4", "CHD7", "CHD8", "CHM", "CHMP1A", "CHORDC1", "CISD2", "CIZ1", "CLASP1", "CLCN7", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT2", "CNP", "COA3", "COA7", "COG4", "COG6", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ5", "COQ8A", "COX15", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSC", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "CYFIP2", "DAG1", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DEGS1", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DICER1", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJC13", "DNAJC21", "DNAJC3", "DNM1", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTNBP1", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFNB1", "EFTUD2", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S3", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ESS2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOC8", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GBA", "GCDH", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GNA11", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2E2", "GTF2I", "GTPBP2", "GTPBP3", "GUF1", "GUSB", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HAX1", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2BP2", "IGF2R", "IMPAD1", "INF2", "INTS1", "IRF2BPL", "IRS4", "ITCH", "ITPA", "IVD", "JAGN1", "JAM3", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KMT2A", "L2HGDH", "LAMB1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD2", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPP", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LSS", "LYRM7", "MACF1", "MAGED2", "MAGT1", "MAN2B1", "MAP1B", "MAP2K1", "MAP2K2", "MAPK1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MESD", "MFF", "MFN2", "MGME1", "MIA3", "MICU1", "MID1", "MIF", "MIPEP", "MMAB", "MMADHC", "MOGS", "MORC2", "MPG", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTHFS", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MYH14", "MYH9", "MYO5A", "MYO6", "NAA10", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NARS2", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCDN", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEK9", "NELFA", "NEMF", "NF1", "NFKB2", "NFU1", "NHLRC2", "NHP2", "NNT", "NONO", "NOP56", "NPC1", "NPM1", "NR3C1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NTHL1", "NUBPL", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "OPTN", "OSGEP", "OTULIN", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PANX1", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDK3", "PDXK", "PEPD", "PEX14", "PEX16", "PEX19", "PEX3", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKB", "PICALM", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PISD", "PITRM1", "PKN1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "POMGNT2", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPP3CA", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCA", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RB1", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RFT1", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF213", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS28", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RREB1", "RRP7A", "RTN2", "RTN4IP1", "SAMHD1", "SAR1B", "SARS", "SARS2", "SBDS", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SDHA", "SDHB", "SEC23A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERAC1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC27A4", "SLC2A1", "SLC33A1", "SLC39A14", "SLC5A6", "SLMAP", "SLTM", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SNAP29", "SNRNP200", "SNRPE", "SOAT1", "SON", "SORD", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SRCAP", "SRP54", "SRP72", "SSBP1", "SSR4", "STAG1", "STAG2", "STAT1", "STAT3", "STIM1", "STK4", "STT3A", "STT3B", "STUB1", "STX3", "SUCLA2", "SUCLG1", "SUZ12", "SYNE2", "TAF15", "TALDO1", "TAP2", "TARDBP", "TARS", "TARS2", "TBCD", "TBCE", "TBL2", "TCF20", "TCOF1", "TDP2", "TECR", "TELO2", "TERF2IP", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM22", "TIMM50", "TIMM8A", "TIMMDC1", "TJP2", "TKT", "TLK2", "TMCO1", "TMEM126A", "TMEM199", "TMEM43", "TMEM70", "TMPO", "TMPO", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOMM40", "TOP2A", "TOR1AIP1", "TP53", "TPI1", "TPM3", "TPP1", "TPP2", "TRAPPC11", "TRAPPC4", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TRRAP", "TSFM", "TTC19", "TTC21B", "TTC37", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUFM", "UBA1", "UBA5", "UBE4A", "UBTF", "UFD1", "UFSP2", "UGDH", "UGP2", "UMPS", "UNC45A", "UPF3B", "UQCC2", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP7", "USP9X", "VAMP7", "VANGL1", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VPS13D", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VRK1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WDR1", "WDR11", "WDR36", "WNK1", "XIAP", "XPC", "XPNPEP3", "YARS", "YARS2", "YIPF5", "YME1L1", "YWHAE", "YWHAG", "ZC3H14", "ZCCHC8", "ZFR", "ZMPSTE24", "ZNF687", "ZPR1"], "leading_proteins": ["AARS2", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACADS", "ACADVL", "ACAT2", "ACOX1", "ACTN4", "ADA", "ADAR", "ADK", "ADNP", "AFG3L2", "AIFM1", "AIP", "ALDH18A1", "ALDH5A1", "ANKLE2", "ANXA11", "AP1B1", "AP2S1", "APC", "ARID1A", "ARL3", "ATAD3A", "ATP2A2", "ATP6", "ATP6V0A2", "ATP6V1E1", "ATP7B", "ATRX", "BCKDK", "BCS1L", "BICD2", "BPTF", "BRAT1", "BRD4", "CARS2", "CASK", "CDC42", "CDK13", "CENPF", "CERS1", "CFL2", "CHD3", "CHMP1A", "CISD2", "CLPP", "CNNM4", "CNP", "COG6", "COQ8A", "COX2", "CPOX", "CPT2", "CRTAP", "CTH", "CTNNB1", "CTNND1", "CYFIP2", "DAG1", "DCTN1", "DDRGK1", "DHCR24", "DHCR7", "DHX16", "DHX37", "DIABLO", "DKC1", "DLAT", "DLG3", "DNAJC3", "DPF2", "DPM1", "ECE1", "EFNB1", "EIF4A3", "EMD", "EPB41", "EPHX2", "ERCC3", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOSC2", "FANCI", "FAR1", "FDFT1", "FECH", "FIP1L1", "FKBP10", "FKBP14", "FRG1", "FUS", "GAPVD1", "GATAD2B", "GBA", "GCDH", "GDAP1", "GFM1", "GLRX5", "GNA11", "GNAI3", "GNE", "GNS", "GTF2E2", "GTPBP3", "HADH", "HADHA", "HIST1H1E", "HLA-A", "HLA-B", "HLA-C", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HTT", "IARS2", "IDH1", "IDH2", "IDH3B", "IGBP1", "IMPAD1", "KDSR", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIFBP", "KMT2A", "LAMB1", "LBR", "LEMD3", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRP1", "LRRC8A", "LYRM7", "MAGT1", "MARS2", "MATR3", "MBOAT7", "MECP2", "MESD", "MFF", "MID1", "MIF", "MIPEP", "MMADHC", "MORC2", "MPG", "MPV17", "MRE11", "MRPS22", "MSH2", "MSH3", "MSH6", "MSMO1", "MTAP", "MTCH1", "MTPAP", "MUT", "MYH14", "MYH9", "MYO5A", "NAGLU", "NBN", "NCSTN", "ND5", "NDUFAF2", "NDUFAF3", "NDUFB10", "NDUFB3", "NDUFS2", "NDUFS8", "NEK9", "NELFA", "NNT", "NONO", "NPC1", "NPM1", "NSD2", "NSMCE3", "NSUN2", "NTHL1", "NUMA1", "NUP107", "NUP133", "NUP160", "NUP37", "NUP85", "NUP93", "OCLN", "OPA3", "OPTN", "OSGEP", "P3H1", "P4HA2", "P4HB", "PARN", "PDHA1", "PDHB", "PEX14", "PEX19", "PEX3", "PGM3", "PIGS", "PIK3C2A", "PIK3R2", "PITRM1", "PLAA", "PLEC", "PLOD1", "PLOD2", "PMPCA", "PMVK", "PNKP", "PNPT1", "POLD1", "POLE", "POLR1B", "POLR2A", "POLR3A", "POMGNT2", "PON2", "POR", "PPOX", "PPP1R12A", "PQBP1", "PRCC", "PREPL", "PRKCA", "PRKCD", "PRKCSH", "PRKRA", "PSAP", "PSMB4", "PTCD3", "PTDSS1", "PTPRF", "PTRH2", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "RAB7A", "RAD50", "RARS2", "RBM10", "RBM12", "RBMX", "RFT1", "RNASET2", "RP2", "RPL15", "RPL18", "RPL26", "RPS10", "RPS6KA3", "RREB1", "SARS2", "SCARB2", "SEC63", "SET", "SF3B1", "SHMT2", "SIGMAR1", "SIL1", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A26", "SLC2A1", "SLC39A14", "SLTM", "SMARCA4", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMPD4", "SMS", "SNAP29", "SOAT1", 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sha256:60ab66b5340ccb5401386c0469d67be8b73f387acd8c2fcfd85045ef9a6c5e3d +size 70791 diff --git a/msigdb_kegg/df_merge.tsv b/msigdb_kegg/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..02922be84fec3dd11e170e55f6c0565e4be80c17 --- /dev/null +++ b/msigdb_kegg/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P53 signaling pathway 2 10 2.222172270051161 0.026271665703708 4.75 13.138349514563108 0.2179791659661161 0.5830709418085639 2.6854742308687665 2.7213262747001785 0.8499311192783285 0.3095875853329852 0.0038219614243763 0.0295498589150116 0.0169766331569465 0.1537817902530961 0.5157725074249294 +Abc transporters 2 6 2.2115063660936296 0.0270007915217753 2.3762135922330097 6.366504854368932 0.6645221155900782 0.3307647417699358 1.8079428939478197 2.1798157082242287 1.1702884010083077 0.2791394174824396 0.0328536036090919 0.0919337377678228 0.1774332758731671 0.01180448121602 0.0701952648708137 +Mismatch repair 1 16 2.148102751096577 0.0317055937338901 4.83252427184466 18.160194174757283 0.0396129719955681 0.5226528038513648 3.232662558988282 1.5481175418750386 1.0072555486723271 0.3057089512016173 0.0393012238682757 0.0058373227860703 0.0224191931510111 0.1139407547181512 0.1083207684216986 +Cell cycle 6 47 2.117516445264257 0.034216041092038 13.774271844660197 51.12378640776699 0.0173991045433985 0.7535224495236807 7.363318835662017 6.012262326651711 0.6471200437086846 0.2867365157911225 0.0156108801532558 0.0180869455940733 0.005348854267881 0.0225148091657114 0.332857932113291 +Progesterone mediated oocyte maturation 3 25 2.0282697094611284 0.0425327286798913 7.487864077669903 26.20145631067961 -0.045720462168252 0.6461945384437632 4.15212523673421 3.724844144199416 0.8126996753235531 0.3168477449517888 0.0055875306330083 0.0421554091664212 0.028249351231176 0.0824194625829831 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b/msigdb_kegg/result.tsv @@ -0,0 +1,62 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P53 signaling pathway 0.768323978261556 2.2221722700511615 0.026271665703708 0.9914814129664437 0.7699268740739599 10 P06493,P24941 2 +Abc transporters 0.8597507106721607 2.2115063660936296 0.0270007915217753 0.9925503620161412 0.7699268740739599 6 P08183,O15439 2 +Mismatch repair 0.6464608184046022 2.148102751096577 0.0317055937338901 0.99687155362747 0.7699268740739599 16 Q9UQ84 1 +Cell cycle 0.5274765446104601 2.117516445264257 0.034216041092038 0.998034297419118 0.7699268740739599 47 Q9Y619,Q9Y3B8,P49841,P53350,P06493,P24941 6 +Progesterone mediated oocyte maturation 0.5594396089070426 2.0282697094611284 0.0425327286798913 0.999581991772317 0.7699268740739599 25 P53350,P06493,P24941 3 +Fatty acid metabolism 0.5353302446914839 1.883555117583268 0.0596251777198586 0.9999833705570184 0.7699268740739599 30 P35610,Q15067,P30837,Q9BWD1,P23786,O15254 6 +Prostate cancer 0.5958736763015094 1.8274363597618395 0.067634186653509 0.999996402878987 0.7699268740739599 15 P24941,P49841 2 +Peroxisome 0.5086526014410582 1.7314375300073772 0.0833737577640914 0.9999998292269652 0.7699268740739599 35 P56589,P34913,Q9BY49,Q9NR77,Q15067,O75381,P33121,O14975,P28288,Q15126,P48735,P39210,O15254 13 +Small cell lung cancer 0.6609169301031055 1.7159612075282769 0.0861691427434605 0.9999999011488884 0.7699268740739599 10 P24941,P07942,O00459 3 +Porphyrin and chlorophyll metabolism 0.5646605035929623 1.6480052946576278 0.0993515846955914 0.9999999926650566 0.7699268740739599 15 P50336,P30519,P22830 3 +Ppar signaling pathway 0.5582833043427367 1.6390002952910636 0.1012131981953139 0.99999999493538 0.7699268740739599 16 Q15067,O95864,P23786,P33121,O15254 5 +Riboflavin metabolism 0.7320821755635787 1.5357653339431443 0.1245959447469602 0.99999999995478 0.7835830427837391 5 Q9NPH0 1 +Biosynthesis of unsaturated fatty acids 0.63986642812266 1.5262436033139488 0.1269492080487622 0.99999999997207 0.7835830427837391 9 Q15067,O15254,Q9BY49 3 +Hypertrophic cardiomyopathy hcm 0.6380178544475039 1.4618483861096814 0.1437827614117135 0.999999999999144 0.8040888618202915 8 P16615,P54619,P67936,P02545,P06753,P50402 6 +Terpenoid backbone biosynthesis 0.6328012424988516 1.3851834988309668 0.165996365033604 0.9999999999999922 0.8040888618202915 7 Q9BWD1,P35610 2 +Colorectal cancer 0.5172434951757792 1.350636101013217 0.1768120304777141 0.9999999999999992 0.8040888618202915 14 P20585,P49841,O00459 3 +Tryptophan metabolism 0.5103402767992231 1.330593756225175 0.1833227180729233 0.9999999999999998 0.8040888618202915 15 P30837,P35610 2 +Chemokine signaling pathway 0.4508139246238966 1.2590822364464669 0.2080006298545966 1.0 0.8040888618202915 28 Q9UBI6,O00459,P49840,Q13464,P49841,P17252 6 +Alpha linolenic acid metabolism 0.9004569190600631 1.2584712218619016 0.2082213885123414 1.0 0.8040888618202915 3 Q15067,O15254 2 +Butanoate metabolism 0.4755937014748528 1.2241648190299166 0.2208900578238317 1.0 0.8040888618202915 19 P30837,P35610 2 +Basal cell carcinoma 0.6541270155926266 1.211246918640017 0.2258007857734212 1.0 0.8040888618202915 5 P49841 1 +Hedgehog signaling pathway 0.6970224316925115 1.111959634954586 0.2661555060787455 1.0 0.8040888618202915 4 P49841 1 +Proteasome 0.4221341780961875 1.0708553665561875 0.2842344674136212 1.0 0.8040888618202915 36 Q99436,P28070,P49721 3 +Steroid biosynthesis 0.4763926395265002 0.8760650866596188 0.3809946514758082 1.0 0.8040888618202915 11 Q16850,Q15392,P35610,P37268 4 +Lysine degradation 0.3918685129960295 0.8439896186021951 0.3986752067796324 1.0 0.8040888618202915 24 P30837,P35610 2 +Homologous recombination 0.4949120192148235 0.8364194690451419 0.4029189636500607 1.0 0.8040888618202915 9 P46100,P49959 2 +T cell receptor signaling pathway 0.4243329222862624 0.8268469379157759 0.4083238219467673 1.0 0.8040888618202915 15 P49841 1 +Arginine and proline metabolism 0.399883047279342 0.8263504928956414 0.4086052983639234 1.0 0.8040888618202915 22 P30837,P52788,O15460 3 +Dilated cardiomyopathy 0.491862157001284 0.8221529821464251 0.4109898345147798 1.0 0.8040888618202915 9 P16615,P17252,P67936,P06753,P50402 5 +Glycine serine and threonine metabolism 0.5076020251586884 0.8147729480898581 0.4152022883594801 1.0 0.8040888618202915 7 O75600 1 +B cell receptor signaling pathway 0.446510922745781 0.7887193208844939 0.430276072886643 1.0 0.8040888618202915 12 P49841 1 +Base excision repair 0.4416622020306699 0.7636711032140662 0.4450632652563027 1.0 0.8040888618202915 12 P09874 1 +Beta alanine metabolism 0.4513634602642815 0.7505520737729763 0.4529222734411444 1.0 0.8040888618202915 11 P30837 1 +Amyotrophic lateral sclerosis als 0.4608556855690332 0.7344278729714603 0.4626880042876538 1.0 0.8040888618202915 10 O96008,P07197,Q08209,P20339 4 +N glycan biosynthesis 0.3948503399271203 0.6530303031437797 0.513736742774932 1.0 0.8168948664911438 14 Q8TCJ2,P04844,O60762,Q96AA3,Q16706 5 +Apoptosis 0.3912686364703764 0.6499972512443991 0.5156939971574808 1.0 0.8168948664911438 16 O95831 1 +Endometrial cancer 0.4061816098943175 0.6451135336431506 0.518853614134754 1.0 0.8168948664911438 13 P49841 1 +Oocyte meiosis 0.3648546675594573 0.6444678314544704 0.5192721110480667 1.0 0.8168948664911438 39 P06493,P24941 2 +Snare interactions in vesicular transport 0.3868504517295967 0.6164361534519296 0.5376066983168464 1.0 0.8168948664911438 15 O95249,P56962,O15400,Q86Y82 4 +Glycerophospholipid metabolism 0.3772342439181185 0.5591900525597192 0.5760320212730323 1.0 0.8168948664911438 14 Q8NCC3,Q96N66,P48651 3 +Leukocyte transendothelial migration 0.3498966694975544 0.55728524347999 0.5773325562367813 1.0 0.8168948664911438 24 P17252,Q13464,Q16625,O00459 4 +Arachidonic acid metabolism 0.5371535484204615 0.5205457164409526 0.6026832728875022 1.0 0.82984850651433 4 P34913,Q9H7Z7 2 +Erbb signaling pathway 0.3640167264373578 0.5092328906113944 0.6105889912608005 1.0 0.8343162552342236 17 P49841 1 +Mtor signaling pathway 0.3916705526283096 0.4674665091696525 0.6401661478791492 1.0 0.848812892373094 11 P23588,Q15418,Q9Y376,O00459 4 +Axon guidance 0.332657166635241 0.4396108483973383 0.6602189821853781 1.0 0.8617603854085069 25 P98172,P49841 2 +Glycosaminoglycan biosynthesis heparan sulfate 0.6544861337683465 0.4324407902751396 0.6654210771166262 1.0 0.8617603854085069 2 O94923 1 +Jak stat signaling pathway 0.4137823352686443 0.4200320209311231 0.6744620617520363 1.0 0.8617603854085069 7 O75928,O00459 2 +Vibrio cholerae infection 0.3303621683853409 0.3734128616997049 0.7088411884164818 1.0 0.8872907183674842 21 Q9Y5K8,P36543,Q93050,P13667 4 +Epithelial cell signaling in helicobacter pylori infection 0.3280859583961427 0.3609488271010211 0.7181377018089505 1.0 0.8926850598875149 21 Q16512,P07948,P60953,Q9Y5K8,Q9BX67,Q93050,Q9Y487,Q9NWH9,P36543 9 +Pathways in cancer 0.305932393659066 0.3512586475139814 0.7253943152666182 1.0 0.8954867753981012 55 O00459,P60953,P12270,P07942,Q16204,P49841,O75928,P20585,P17252,P25054,P24941,P06753 12 +Aldosterone regulated sodium reabsorption 0.3465046609071956 0.280507955319743 0.7790878229039933 1.0 0.9359511429517772 11 Q9Y3B8,O00459 2 +Fc epsilon ri signaling pathway 0.3323745190648549 0.2594296471067845 0.7953037574457742 1.0 0.9469368585930223 12 P17252,O00459 2 +Insulin signaling pathway 0.3016060094199299 0.2073231140785017 0.8357575238613308 1.0 0.9714324465660924 37 Q9UPT5,P49841,P41440 3 +Notch signaling pathway 0.4129937969311165 0.1809918362032913 0.8563739839566686 1.0 0.972341112909824 4 P56545,Q13573,Q92542 3 +Viral myocarditis 0.298823420321925 0.1240483652510969 0.9012769808327292 1.0 0.9762777288605984 11 P35579,P04439,Q7Z406,P35580 4 +Systemic lupus erythematosus 0.2809220431467051 0.114800909658891 0.9086029280215124 1.0 0.9762777288605984 13 P19474,P10155,O43707,P84243 4 +Thyroid cancer 0.2964944838073352 0.1002037460120313 0.9201825720978684 1.0 0.9762777288605984 10 P12270,Q16204,P06753 3 +Nitrogen metabolism 0.3512895853738189 0.0833782336885372 0.9335507952390594 1.0 0.9772256862443954 4 P08243,P32929,P00367 3 +Glutathione metabolism 0.2575869255779005 0.0504756959229445 0.959743316554728 1.0 0.9873221474902087 21 P48735,P52788 2 +Vegf signaling pathway 0.241024964116027 0.0233009896709017 0.9814101822859628 1.0 1.0 13 P17252,O00459 2 +Non homologous end joining 0.2440743635047118 0.0058261465264683 0.9953514339360454 1.0 1.0 6 P49959,Q92878 2 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..fba261a066d9d50508406ea55fd2e7907fac41d4 --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "APPL1", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG7", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATR", "ATRX", "B4GAT1", "BAIAP2", "BCAS2", "BCAT2", "BCKDHA", "BCR", "BDH2", "BIRC6", "BLVRA", "BLVRB", "BNIP1", "BPNT1", "BUB1B", "BUB3", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CARS2", "CASK", "CBR1", "CCDC6", "CCNB1", "CD47", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDS2", "CETN2", "CFL1", "CFL2", "CHD8", "CHERP", "CHMP6", "CHORDC1", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "COMT", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DEGS1", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIS3", "DLAT", "DLD", "DLST", "DNA2", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK1", "DPM1", "DPYSL2", "DPYSL5", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "EMD", "ENAH", "ENDOD1", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERBIN", "ERCC2", "ERCC3", "ERO1A", "EXO1", "EXOC3", "EXOC4", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FOXO3", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLM", "GFPT1", "GGA1", "GGA2", "GGCT", "GGH", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GRB2", "GRHPR", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HADH", "HADHA", "HADHB", "HAGH", "HCCS", "HDAC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIP1", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2R", "IMPDH2", "IQGAP1", "IQGAP2", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JAM3", "JUP", "KARS", "KDSR", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LCLAT1", "LDHA", "LDHB", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LSM2", "LSM6", "LSS", "LTA4H", "LYN", "LYPLA1", "M6PR", "MAD2L1", "MAN2A1", "MAN2B1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MGST2", "MGST3", "MID1", "MIF", "MMAB", "MOGS", "MPG", "MPHOSPH6", "MPI", "MPST", "MPV17", "MRE11", "MRPL13", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTOR", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NARS2", "NBN", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NF1", "NFKB2", "NGEF", "NIT2", "NLN", "NME1", "NME2", "NNT", "NPC1", "NR3C1", "NSD2", "NSD3", "NSDHL", "NSF", "NT5C2", "NTHL1", "NUDT12", "NUDT5", "NUDT9", "OAT", "OCLN", "OGDH", "ORC3", "ORC5", "OXA1L", "P4HA1", "P4HA2", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PC", "PCBP1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PECR", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PHF5A", "PHGDH", "PHKB", "PIAS2", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKN1", "PLA2G15", "PLCG1", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLXNB2", "PMPCA", "PMVK", "PNP", "PNPT1", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "PPA1", "PPA2", "PPAT", "PPID", "PPIH", "PPIL1", "PPIL2", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTDSS1", "PTGES2", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QPRT", "RAB13", "RAB31", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAC1", "RAD21", "RAD23B", "RAD50", "RALA", "RALB", "RAPGEF2", "RARS", "RARS2", "RB1", "RBM17", "RBM22", "RBM25", "RBM8A", "RBMX", "RCOR1", "RDH11", "RDX", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RIPK1", 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2.3938503595706133 0.01667254935181 5.254854368932039 9.893203883495143 0.0168746556788541 0.5228319015695678 2.816491091086608 1.1205288397723716 0.9907162189370564 0.3181797684516186 0.0231057649354089 0.0652597674910206 0.0078714328443906 0.0439142352380576 0.1457988469723397 +Apc c mediated degradation of cell cycle proteins 7 60 2.389006597732442 0.0168939989715772 16.58009708737864 56.25970873786408 0.4894986081915347 0.5846445085026403 8.225929403640711 3.549651687085986 1.2134956516570392 0.3755323963670207 0.0078467631278517 0.0068431745235502 1.2701489161645118e-05 0.0007410319848467 0.0056304221630037 +Translation of sars cov 1 structural proteins 1 7 2.3593791369150146 0.0183055427691722 2.4223300970873787 6.516990291262136 0.2000582351843073 0.5481069552771392 1.643252283063436 0.9715380009471484 0.8883530031630541 0.303698878937936 0.0360824876045856 0.0049155620827658 0.0190005699483642 0.0983610682747182 0.2898287915273368 +Tp53 regulates transcription of cell cycle genes 2 13 2.323957143938341 0.0201277910722346 5.092233009708738 15.592233009708735 -0.1377848768994166 0.6453639748045861 3.1663028368184145 2.218356310966637 0.73671025302338 0.2924169623156991 0.0022697669771903 0.0180235679120217 0.0082729445560879 0.0854582473740603 0.347580215848049 +Maturation of sars cov 2 nucleoprotein 1 5 2.275342543906087 0.0228853891719131 2.412621359223301 4.985436893203883 0.0067238540290333 0.5371553195215879 1.444653995706506 0.9577388182984884 0.9451900366181616 0.3092790872936227 0.0214721625357582 0.0017062060788896 0.0067896670197663 0.0382400085743442 0.1289341732663725 +Egr2 and sox10 mediated initiation of schwann cell myelination 2 7 2.2752677543421016 0.0228898725654422 1.5631067961165048 6.456310679611651 0.9405466898133904 0.3504222949879002 1.1919625891097876 1.444955732376159 0.8981851290078471 0.2877478182828594 1.0 0.0919337377678228 0.0158256043387446 0.0834574734746242 0.0701952648708137 +G2 m checkpoints 8 80 2.2269009405715425 0.0259538949762143 20.961165048543688 83.21601941747574 0.2497590522742128 0.6198120617040068 11.249096904504546 6.6438113169442845 1.0983784482763044 0.3587806160447286 0.0013188919413374 0.0038246242160168 0.0003155694632167 0.0052370120210683 0.0610477161186252 +Regulation of tp53 activity through phosphorylation 3 25 2.211556362214667 0.026997333424271 9.16504854368932 31.033980582524272 -0.166760358087954 0.6053682165807477 5.2682361731688045 5.209104304015077 0.8414955883036344 0.3086775406206219 0.0080350743708833 0.0589240460435226 0.0082058667706489 0.1374400519295191 0.2071976594921332 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 1 7 2.140011502519806 0.0323538371783944 3.4199029126213594 8.004854368932039 -0.0074914025899924 0.5778505619608933 2.1902014781398274 0.9951219509377702 0.8292091582875282 0.2994121402505436 0.0296145418928731 0.083126337411673 0.012905013470629 0.0693365470158766 0.2166689846253057 +Class i peroxisomal membrane protein import 3 11 2.1344865963188617 0.0328029696964065 4.300970873786408 9.604368932038836 1.1426576411245968 0.2560233101944223 2.515331441636984 1.9424437465598188 1.2133199793435778 0.2911424942178205 1.0 0.0875404472016038 0.1693528922958147 0.0102137155300364 0.0118865434534573 +Fatty acid metabolism 17 58 2.095001840847194 0.0361708288392721 12.601941747572816 56.89320388349515 -0.6410370109047604 0.354277511640737 6.622394788478767 4.797678689021568 1.3258270224785833 0.3264233172937892 0.1782831463897266 0.0023437820755387 0.0001363362205479 2.5208008683948227e-05 1.2512597553716874e-05 +Metabolism of folate and pterines 1 7 2.063396504474471 0.0390749717958143 1.8106796116504855 8.368932038834952 1.1027495377425318 0.3107646321591615 1.2630224668311476 0.7725922983430199 0.836443902773376 0.2729501818402672 1.0 0.0697581245313758 0.1362380906066266 0.307957256786686 0.1630814235328921 +Collagen biosynthesis and modifying enzymes 4 11 2.059088587626185 0.0394857528998426 3.5800970873786406 10.699029126213592 0.3805554574163366 0.5145805337299729 2.1668042752572436 0.8015149667162244 0.9486467410293076 0.31672669778814 0.0488968448910572 0.0090330503435184 0.03403446937649 0.0056128198685199 0.0137665493817408 +Cholesterol biosynthesis 6 15 1.9808231296038457 0.0476111120094286 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 1.0 1.0 0.0224191931510111 1.774557205833731e-05 0.0001024209024739 +Regulation of tp53 expression and degradation 1 8 1.97781331856754 0.0479497704365126 3.6966019417475726 10.317961165048544 0.294217562214269 0.6081549616972154 2.5840601955018023 2.0297227603613113 0.762833700222209 0.3012258595302401 0.001340238952411 0.0108643857486399 0.0405463165390607 0.1899587232036964 0.4808786474245576 +Non integrin membrane ecm interactions 3 7 1.9749025683885555 0.0482792058869709 2.3810679611650487 5.682038834951456 -0.0725412144856926 0.5776386594360561 1.652573992657068 1.8534585143755615 0.8819938971562727 0.3098953498776026 1.0 1.0 1.0 1.0 0.1028731839020021 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..193ee9ac032abaead1e14011c3e4c9800d74a2c7 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 1388, + "title": "Average number of proteins per term", + "value": 18.930115273775215 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c93a7da349341f66b5b0b228fa13a0ae9045e835 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..83366a35e0f7654a19e54627bc4d44cba8a2d8c9 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,448 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Phase i functionalization of compounds 0.7311328638900682 2.570647985939489 0.0101508447318341 0.9999992923878044 0.488617180069445 15 P30837,P07099 2 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.72888906295254 2.5204315933049304 0.0117211018455163 0.999999921877338 0.488617180069445 14 Q13217,P07237,Q86UP2,Q07065,P07942,Q02818,Q15084,O43852,Q15293 9 +Translation of sars cov 2 structural proteins 0.6851643757658521 2.4068093712831415 0.0160925674240464 0.9999999998338552 0.488617180069445 17 P49840 1 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.8309338727312957 2.3938503595706133 0.01667254935181 0.9999999999267092 0.488617180069445 9 P06493 1 +Apc c mediated degradation of cell cycle proteins 0.4977840914340865 2.389006597732442 0.0168939989715772 0.9999999999463856 0.488617180069445 60 Q96GD4,P28070,P53350,P06493,P24941,P49721,Q99436 7 +Translation of sars cov 1 structural proteins 0.8550066939328589 2.3593791369150146 0.0183055427691722 0.9999999999927028 0.488617180069445 7 P49840 1 +Tp53 regulates transcription of cell cycle genes 0.7171192649899478 2.323957143938341 0.0201277910722346 0.9999999999994464 0.5079522546956662 13 P06493,P24941 2 +Maturation of sars cov 2 nucleoprotein 0.9162784913280416 2.275342543906087 0.0228853891719131 0.9999999999999888 0.5323510132320617 5 P49840 1 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.8349290087608089 2.2752677543421016 0.0228898725654422 0.999999999999989 0.5323510132320617 7 Q9NR77,Q16850 2 +G2 m checkpoints 0.4632153176084192 2.2269009405715425 0.0259538949762143 1.0 0.5489103128096631 80 Q9Y3B8,P28074,P28070,Q9UQ84,P06493,P24941,P49721,Q99436 8 +G0 and early g1 0.9844097561945486 2.216906839247847 0.0266294583115915 1.0 0.5489103128096631 4 P06493 1 +Regulation of tp53 activity through phosphorylation 0.5863994695793511 2.211556362214667 0.026997333424271 1.0 0.5489103128096631 25 Q96GD4,P24941,Q9UQ84 3 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.8030499816767324 2.140011502519806 0.0323538371783944 1.0 0.6040630619009593 7 P06493 1 +Class i peroxisomal membrane protein import 0.7257849024831845 2.1344865963188617 0.0328029696964065 1.0 0.6040630619009593 11 Q9NR77,P28288,O75381 3 +Fatty acid metabolism 0.4779515394410595 2.095001840847194 0.0361708288392721 1.0 0.604880848541081 58 P34913,Q9BY49,Q15165,Q8IVS2,Q15067,O43772,P23786,P33121,O95864,Q8N8N7,Q14914,O14975,Q9UMR5,P09960,Q9H7Z7,O15254,P42126 17 +Metabolism of folate and pterines 0.7852061445599012 2.063396504474471 0.0390749717958143 1.0 0.6447791179409605 7 P41440 1 +Collagen biosynthesis and modifying enzymes 0.7101981564803682 2.059088587626185 0.0394857528998426 1.0 0.6447791179409605 11 O15460,Q32P28,P13674,O75718 4 +Cholesterol biosynthesis 0.6229440782905081 1.9808231296038457 0.0476111120094286 1.0 0.6548936403625141 15 Q15392,P37268,Q16850,Q9BWD1,Q14739,Q15126 6 +Regulation of tp53 expression and degradation 0.751394040920006 1.97781331856754 0.0479497704365126 1.0 0.6548936403625141 8 P06493 1 +Non integrin membrane ecm interactions 0.7647789834424661 1.9749025683885555 0.0482792058869709 1.0 0.6548936403625141 7 O14936,P17252,P07942 3 +Diseases of mitotic cell cycle 0.6117582522667332 1.9505834811823557 0.0511066138167191 1.0 0.6568146294222789 16 P24941,P46100 2 +Dna damage telomere stress induced senescence 0.5969905887734499 1.9402564464652376 0.05234853160703 1.0 0.6605432897323423 18 P10412,Q92878,P07305,Q9NYB0,P49959,P20700,P16402,P16403,P24941,Q9Y6J0 10 +Activation of nima kinases nek9 nek6 nek7 0.9044063074508724 1.917246017517103 0.0552066844083385 1.0 0.6846368558985707 4 P06493 1 +Phosphorylation of the apc c 0.6349679206898879 1.8948140120549375 0.0581170461824085 1.0 0.695400518113647 13 P53350,P06493 2 +Diseases of dna repair 0.7174416469484716 1.8876393076647149 0.0590743893120646 1.0 0.7008141227790236 9 P20585,Q9UQ84,P49959,P78549 4 +Cell surface interactions at the vascular wall 0.5849015966113835 1.8676790079035952 0.061806826366495 1.0 0.7107622263046501 18 P53985,Q9UNN8,P14174 3 +E2f enabled inhibition of pre replication complex formation 0.8098513591330528 1.8540597923462712 0.0637306062171934 1.0 0.7250662412251183 5 P06493 1 +G2 m dna damage checkpoint 0.5277049598618884 1.8356250567209549 0.0664131287197189 1.0 0.7299772049658785 31 P06493,Q9UQ84 2 +Hdr through homologous recombination hrr 0.5654670294641057 1.8355736427930365 0.0664207382790842 1.0 0.7299772049658785 20 Q9UQ84 1 +Condensation of prophase chromosomes 0.6856343317932725 1.83473160377868 0.0665454671676577 1.0 0.7299772049658785 10 P53350,P06493,Q01105 3 +Initiation of nuclear envelope ne reformation 0.5914234489443515 1.8330720136464371 0.0667918624140249 1.0 0.7299772049658785 16 P06493,Q86XL3,Q14739 3 +Cyclin a b1 b2 associated events during g2 m transition 0.7043281401719156 1.8273511358576324 0.0676469912813235 1.0 0.7335470617068525 9 P06493,P24941 2 +Homology directed repair 0.5159905766680686 1.7760516386408185 0.0757244062684507 1.0 0.7611815764179306 34 P24941,Q9UQ84,P41440 3 +Syndecan interactions 0.7840695617996665 1.7493955378185768 0.0802226716596106 1.0 0.7611815764179306 5 O14936,P17252 2 +Protein localization 0.4145259102124584 1.7463041702005064 0.080758111626185 1.0 0.7611815764179306 76 Q5JRX3,Q99595,Q9NR77,Q15067,O60830,P50402,O15254,P06576,O75381,O14975,P56589,Q9NS69,Q7L5D6,Q9BY49,P21796,P28288,P39210,P34913,Q10713 19 +Transcriptional regulation by runx2 0.4610268934804999 1.729821421250518 0.0836621859724198 1.0 0.7611815764179306 53 P28074,P28070,P49841,P06493,P49721,Q99436 6 +Ercc6 csb and ehmt2 g9a positively regulate rrna expression 0.6226473833052104 1.7211859278947357 0.0852170905365632 1.0 0.7611815764179306 12 O95983,P16104,Q13185,Q86YP4,Q8WXI9,Q12873,P84243 7 +Golgi cisternae pericentriolar stack reorganization 0.6412226099700755 1.718353915782196 0.0857320806696098 1.0 0.7611815764179306 11 P06493 1 +Metabolism of porphyrins 0.6573292555006781 1.698618788725395 0.0893910339820358 1.0 0.7611815764179306 10 P50336,P30519,P22830 3 +Heme biosynthesis 0.7347929577697966 1.690495235419329 0.0909332490172158 1.0 0.7611815764179306 6 P50336,P22830 2 +Slc mediated transmembrane transport 0.5088738462150388 1.6772208268255722 0.0934993078761254 1.0 0.7611815764179306 26 Q99808,P53985,P30825,Q8TAD4 4 +Arachidonic acid metabolism 0.6810516255145926 1.660315429665222 0.0968510132957216 1.0 0.7611815764179306 8 Q15165,P34913,Q8N8N7,Q9H7Z7 4 +Sphingolipid de novo biosynthesis 0.6296098359464513 1.659934907854517 0.0969275480059805 1.0 0.7611815764179306 11 Q06136,Q96G23 2 +Maturation of sars cov 1 nucleoprotein 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.7611815764179306 2 P49840 1 +Rhobtb1 gtpase cycle 0.5354509137919478 1.644977657918396 0.0999744185832223 1.0 0.7611815764179306 20 Q5VTR2,P08670,P07910,Q8N684,Q13464,P38159,P62995,O43396 8 +The role of gtse1 in g2 m progression after g2 checkpoint 0.4650613825428032 1.640980353792971 0.1008014934475782 1.0 0.7611815764179306 49 P28070,P53350,P06493,P49721,Q99436 5 +Mismatch repair 0.6624182914807254 1.6324184281169944 0.1025913696448013 1.0 0.7611815764179306 9 Q9UQ84 1 +Rac2 gtpase cycle 0.4902276741873921 1.6015367403131 0.1092580892691721 1.0 0.7611815764179306 36 Q8TAA9,Q14185,O00459,P60953,Q9H0H5,Q86XL3,Q6IAA8,Q14739,Q5T2T1,Q9UH62,O15173,P50402,Q07960 13 +Collagen formation 0.5781236645149144 1.5872158261125304 0.112463771584041 1.0 0.7611815764179306 13 O15460,Q32P28,P13674,O75718 4 +Rho gtpases activate pkns 0.5314657841153447 1.578367481955825 0.1144812111952866 1.0 0.7611815764179306 19 Q9Y3B8,P16104,O14974,P35579,Q7Z406,P60660,P35580,P31946,P84243 9 +Extracellular matrix organization 0.4915349532631765 1.5642584875650631 0.1177568767712899 1.0 0.7611815764179306 30 O75718,P07237,O14936,Q32P28,P55081,O15460,P17252,P13674,P07942 9 +Regulation of tp53 activity 0.4744403176890248 1.5623895917417712 0.1181962375511844 1.0 0.7611815764179306 42 Q96GD4,P06493,P24941,Q9UQ84 4 +Gpcr ligand binding 0.647100557338913 1.560389652993714 0.1186678284847693 1.0 0.7611815764179306 9 P42892 1 +Activation of kainate receptors upon glutamate binding 0.8105579077002929 1.5560022790706938 0.1197075504239761 1.0 0.7611815764179306 4 Q9UBI6 1 +Scf skp2 mediated degradation of p27 p21 0.4735530816086932 1.5551246281217272 0.1199163905111582 1.0 0.7611815764179306 42 Q99436,P24941,P28070,P49721 4 +Ras processing 0.7002150797581799 1.5419624592367245 0.1230827164515648 1.0 0.7611815764179306 6 P49354 1 +G1 s dna damage checkpoints 0.4754473452005612 1.537676447268082 0.1241277452172455 1.0 0.7611815764179306 40 Q99436,P24941,P28070,P49721 4 +Ire1alpha activates chaperones 0.5026153906108161 1.522433088732676 0.1279005991886661 1.0 0.7611815764179306 22 Q9NWM8,Q13217,P49840,Q15084 4 +Transport of inorganic cations anions and amino acids oligopeptides 0.6018855627285882 1.5194180923766327 0.1286572907481749 1.0 0.7611815764179306 11 P30825 1 +Dna double strand break repair 0.4621788540766129 1.5185555680865792 0.1288744023474162 1.0 0.7611815764179306 45 P24941,Q9UQ84,P41440 3 +Mitotic g1 phase and g1 s transition 0.3897206562946558 1.5079733758754286 0.1315613412559653 1.0 0.7667722468180528 73 P28074,P28070,P06493,P24941,P49721,Q99436 6 +Rac3 gtpase cycle 0.4811040865038284 1.5042381568917569 0.1325200562317898 1.0 0.7667722468180528 33 Q8TAA9,O00459,P60953,P51149,Q15758,Q9H0H5,Q14126,Q9BSJ8,Q14739,Q9UQB8,Q5T2T1,Q6IAA8,O15173,P50402,Q07960 15 +Dual incision in gg ner 0.5175380234426161 1.4905693300878309 0.1360746015526168 1.0 0.7667722468180528 19 P41440 1 +Cyclin a cdk2 associated events at s phase entry 0.4624901048631747 1.4818575349257146 0.1383782062590912 1.0 0.7667722468180528 43 Q99436,P24941,P28070,P49721 4 +Signal amplification 0.6539880470664564 1.4816001776422565 0.1384467117414392 1.0 0.7667722468180528 7 Q9UBI6,P63218,Q14344,Q13685 4 +Orc1 removal from chromatin 0.4398285742968435 1.4719826833139322 0.1410255538418992 1.0 0.7689026276205226 51 P28074,P28070,P24941,P49721,Q99436 5 +Formation of fibrin clot clotting cascade 0.9494346351232716 1.4343343024582849 0.1514768858853981 1.0 0.7733244790935758 3 P42785 1 +Abc family proteins mediated transport 0.4248551328382399 1.4259792717675044 0.1538743254154322 1.0 0.7733244790935758 54 P28074,P08183,P28070,O15439,P49721,Q99436 6 +Base excision repair 0.4721257605153184 1.4144256332198168 0.1572369682198571 1.0 0.7733244790935758 25 P78549,P09874,Q9NYB0,P41440 4 +Depolymerisation of the nuclear lamina 0.5812678514420786 1.4141038237175485 0.1573314206245131 1.0 0.7733244790935758 11 P20700,P42167,P17252,P14635,Q9Y2U8,P06493,P50402 7 +Apc c cdc20 mediated degradation of cyclin b 0.5628025154318141 1.4058553832222769 0.1597670723232434 1.0 0.7733244790935758 12 P06493 1 +Rhoa gtpase cycle 0.4511230961383407 1.4053242825870422 0.1599248708059608 1.0 0.7733244790935758 44 Q8TAA9,O00459,Q9H0H5,Q13464,Q8N5V2,P30519,Q96HY6,P28288,Q14739,P41440,O15173,Q07960 12 +Transcriptional regulation of granulopoiesis 0.6124420763995224 1.396146959650196 0.1626702451161226 1.0 0.7758979389043924 9 P24941,P84243 2 +Termination of translesion dna synthesis 0.516741844379266 1.3920622923715047 0.1639035355223574 1.0 0.7767762043830992 16 P41440 1 +Switching of origins to a post replicative state 0.3940242515344733 1.390732562486419 0.1643065394961615 1.0 0.7767762043830992 61 Q9Y619,P28074,P28070,P24941,P49721,Q99436 6 +Resolution of abasic sites ap sites 0.4891247898075828 1.386309024702459 0.1656525623180096 1.0 0.7767762043830992 21 P78549,P09874,P41440 3 +Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.5108350667825858 1.3834046313408026 0.16654083127336 1.0 0.777020614769597 17 P41440 1 +Pink1 prkn mediated mitophagy 0.6319988295225916 1.3815229922593553 0.1671182133435773 1.0 0.777020614769597 7 P21796,Q9NS69 2 +G1 s specific transcription 0.6193969236333781 1.375218988373204 0.1690635631559209 1.0 0.777020614769597 8 P06493 1 +Meiotic recombination 0.5895389963095182 1.3668088720639615 0.1716852211640867 1.0 0.7777465110957895 10 P24941,P49959,P84243 3 +Striated muscle contraction 0.6907250163292098 1.3639493104584677 0.1725835197532443 1.0 0.7777465110957895 5 P67936,Q9NYL9,P08670,P06753 4 +Phosphorylation of emi1 0.9286190226480606 1.3595312513700235 0.1739783064879541 1.0 0.7814947877193537 3 P06493 1 +Hdacs deacetylate histones 0.5358203623475076 1.3539988695383691 0.1757367383752661 1.0 0.7868470737576433 13 O95983,Q86YP4,O75446,Q8WXI9,Q12873 5 +Constitutive signaling by akt1 e17k in cancer 0.682216596076601 1.3284741890746812 0.1840215048609086 1.0 0.8009722077720725 5 P49840 1 +Assembly of the orc complex at the origin of replication 0.5975788457683334 1.3252891889898069 0.1850752533285913 1.0 0.8027639113127648 9 Q9UBD5,Q9Y619,P84243 3 +Regulation of mecp2 expression and activity 0.5803106251518656 1.3211733825064167 0.1864435593044682 1.0 0.8032961492816543 10 Q96GD4,Q14739 2 +Linoleic acid la metabolism 0.9001631321370271 1.3209110923303766 0.1865310107547975 1.0 0.8032961492816543 2 P33121 1 +Dna replication pre initiation 0.3784357058154282 1.3176353264820946 0.1876257539014179 1.0 0.8032961492816543 63 P28074,P28070,P24941,P49721,Q99436 5 +Thromboxane signalling through tp receptor 0.6768366928102721 1.30603036373081 0.1915422320398687 1.0 0.8063620511285355 5 Q9UBI6,Q14344,Q13685 3 +Positive epigenetic regulation of rrna expression 0.4571460896701052 1.3055244696095525 0.1917143205132685 1.0 0.8063620511285355 26 O95983,O00159,P16104,Q13185,P49841,Q86YP4,Q8WXI9,O15446,Q12873,Q9H9Y6,P84243 11 +Rac1 gtpase cycle 0.440396171850459 1.297827352337062 0.1943466683232513 1.0 0.8149642768358696 43 Q8TAA9,Q14185,O00459,P60953,Q86UP2,Q9H0H5,Q8N5V2,Q6IAA8,Q14739,Q9UQB8,Q15758,Q96F07,Q5T2T1,P50402,Q07960 15 +Processing of dna double strand break ends 0.4545184088802714 1.290240528052662 0.1969671586343029 1.0 0.8234651089891941 24 Q9UQ84 1 +Protein protein interactions at synapses 0.5030966105244297 1.2879481978245713 0.1977639961594683 1.0 0.824313593601628 15 O14936,Q14168,P41440,Q92796 4 +Cdc42 gtpase cycle 0.4524566753975046 1.2814855401477352 0.2000231756745036 1.0 0.8265386204117244 32 Q8TAA9,O00459,P60953,Q86UP2,Q9H0H5,P27105,Q8N5V2,Q8N6H7,Q14344,A4D1P6,Q14739,Q9UQB8,Q6IAA8,Q07960 14 +Peroxisomal lipid metabolism 0.5393346526540207 1.2807696937343829 0.2002745719077823 1.0 0.8265386204117244 12 Q15067,O15254,Q9BY49 3 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.4153693877822823 1.2760107939985892 0.2019517034716067 1.0 0.8265386204117244 52 Q96GD4,P28070,P53350,P49721,Q99436 5 +Synaptic adhesion like molecules 0.6054929837943254 1.2603398243942507 0.2075467994436568 1.0 0.8265386204117244 7 P41440 1 +G alpha z signalling events 0.604908646765667 1.2576638448891213 0.2085133530626119 1.0 0.8265386204117244 7 Q9UBI6 1 +Long term potentiation 0.6631285937376372 1.2488181622624672 0.2117315894455704 1.0 0.8265386204117244 5 Q92796 1 +Unblocking of nmda receptors glutamate binding and activation 0.6631285937376372 1.2488181622624672 0.2117315894455704 1.0 0.8265386204117244 5 Q92796 1 +Ras activation upon ca2 influx through nmda receptor 0.6631285937376372 1.2488181622624672 0.2117315894455704 1.0 0.8265386204117244 5 Q92796 1 +Formation of senescence associated heterochromatin foci sahf 0.56531978286614 1.246912956505869 0.2124294154503831 1.0 0.8265386204117244 10 P10412,P07305,P20700,P16402,P16403 5 +Pre notch expression and processing 0.6021179374681845 1.244882097497478 0.2131750924706419 1.0 0.8265386204117244 7 P16104,Q9HCE1,P84243 3 +Synthesis of leukotrienes lt and eoxins ex 0.879282218597058 1.2385840457469472 0.2154995794764007 1.0 0.8265386204117244 2 Q14914 1 +Insulin processing 0.5470108983050737 1.2380850551442983 0.2156845246989089 1.0 0.8265386204117244 11 O60645,Q9UPT5,Q8TAD4 3 +Hdms demethylate histones 0.5897718125890024 1.236796941577589 0.2161624778166109 1.0 0.8265386204117244 8 Q8NB78 1 +Smooth muscle contraction 0.5445233309208259 1.2252751831288178 0.2204715555220189 1.0 0.8293076397413611 11 P08133,P60660,P67936,P06753 4 +Mitotic g2 g2 m phases 0.380206011282592 1.2051970791631872 0.228127229695854 1.0 0.8511843946716277 88 Q96CV9,P28074,O43805,P49454,P28070,Q7Z4H7,O95684,P17252,Q9H6D7,Q92530,P53350,P06493,P24941,P21127,P49721,Q99436 16 +Negative regulation of nmda receptor mediated neuronal transmission 0.5925776845999242 1.2011718977440322 0.2296845280191868 1.0 0.8546973857657676 7 Q14168,Q92796 2 +Biosynthesis of specialized proresolving mediators spms 0.8795691906005302 1.1837646519924174 0.2365062383608966 1.0 0.8630734934822522 3 P34913,Q14914 2 +Peptide hormone metabolism 0.4850092334568643 1.1813625613362055 0.2374587241098362 1.0 0.8630734934822522 15 O60645,Q9UPT5,Q8TAD4 3 +Metabolism of steroid hormones 0.6162148888019446 1.1764948564877031 0.2393971865926996 1.0 0.8630734934822522 6 P30536 1 +Cell death signalling via nrage nrif and nade 0.5831848496338967 1.1581305215188376 0.2468107762223601 1.0 0.868697347075642 7 Q8N5V2,Q14344,Q9NY61 3 +Rhob gtpase cycle 0.4483156500139546 1.1536550559502357 0.2486416168894847 1.0 0.868697347075642 22 O00459,Q9H0H5,Q13464,P41440,Q07960 5 +Meiosis 0.4352763859926753 1.1525543938362135 0.2490933315101624 1.0 0.868697347075642 24 Q92878,Q8WXH0,P16104,Q9NYB0,P49959,Q8WVM7,P20700,Q9UH99,P24941,Q8N3U4,P84243 11 +Reproduction 0.4352763859926753 1.1525543938362135 0.2490933315101624 1.0 0.868697347075642 24 Q92878,Q8WXH0,P16104,Q9NYB0,P49959,Q8WVM7,P20700,Q9UH99,P24941,Q8N3U4,P84243 11 +S phase 0.3802877599422046 1.1441245201538983 0.2525720000751277 1.0 0.8757112965202937 93 Q9Y619,P28074,P28070,P49841,Q8WVM7,P41440,P24941,P49721,Q99436 9 +Pregnenolone biosynthesis 0.7015920398774721 1.129784885096155 0.2585668787014035 1.0 0.8757112965202937 4 P30536 1 +Nod1 2 signaling pathway 0.6998483460790067 1.1229809922209932 0.2614455672733609 1.0 0.8757112965202937 4 Q13685,Q15750 2 +Activation of the pre replicative complex 0.4586568592485381 1.1163015963067555 0.264293058559967 1.0 0.8757112965202937 19 P24941 1 +Nrage signals death through jnk 0.6298058235460555 1.109854657836857 0.2670616618482102 1.0 0.8757112965202937 5 Q8N5V2,Q9NY61 2 +Polo like kinase mediated events 0.8558246016961896 1.0992792206431845 0.2716462930996606 1.0 0.8757112965202937 3 P53350 1 +Synthesis of dna 0.3651509611232421 1.0986153773773224 0.2719358674665271 1.0 0.8757112965202937 83 P28074,P28070,P41440,P24941,P49721,Q99436 6 +Abc transporters in lipid homeostasis 0.8520456745062206 1.0858899595570666 0.2775276795524179 1.0 0.8757112965202937 3 P28288 1 +Purine salvage 0.6236759504255762 1.084355980736723 0.278206993174833 1.0 0.8757112965202937 5 P55263 1 +Biological oxidations 0.4136610771428384 1.0745428860917032 0.2825794342545196 1.0 0.8757112965202937 43 P30837,P07099,Q16850 3 +Assembly and cell surface presentation of nmda receptors 0.5295647078895043 1.0696633111769498 0.2847708863402833 1.0 0.8757112965202937 10 O14936,Q92796 2 +Neurexins and neuroligins 0.52874164949745 1.0655897152840828 0.2866091503978252 1.0 0.8757112965202937 10 O14936,Q14168,Q92796 3 +Infection with mycobacterium tuberculosis 0.4654372782079191 1.050920686922138 0.2932950183905669 1.0 0.8757112965202937 14 P49840 1 +Response of mtb to phagocytosis 0.4654372782079191 1.050920686922138 0.2932950183905669 1.0 0.8757112965202937 14 P49840 1 +Amino acid transport across the plasma membrane 0.6152569995453524 1.0493924403675283 0.2939975360702622 1.0 0.8757112965202937 5 Q15758,P30825 2 +Regulation of runx2 expression and activity 0.4050712248835499 1.048951766336131 0.2942003183806951 1.0 0.8757112965202937 46 Q99436,P28070,P49841,P49721 4 +Pi3k akt signaling in cancer 0.4944516712250637 1.0411379218303234 0.2978115418122109 1.0 0.8757112965202937 12 P49840,P49841 2 +G protein beta gamma signalling 0.6771139405811459 1.034543980554692 0.3008819272575747 1.0 0.8757112965202937 4 Q9UBI6,P63218,P60953 3 +G beta gamma signalling through cdc42 0.6771139405811459 1.034543980554692 0.3008819272575747 1.0 0.8757112965202937 4 Q9UBI6,P63218,P60953 3 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.5365987840152506 1.0337453875548608 0.3012552086223592 1.0 0.8757112965202937 9 Q9HA64,Q9BU89 2 +Mitophagy 0.5221884395427183 1.0331799118238163 0.3015197118629067 1.0 0.8757112965202937 10 P21796,Q9NS69 2 +Rhod gtpase cycle 0.4194756324416371 1.0326798861035371 0.3017537294094148 1.0 0.8757112965202937 26 Q8TAA9,O00459,P51149,Q9H0H5,P20700,Q9BSJ8,Q14739,O15173,P50402,Q07960 10 +Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.5555186007743205 1.031538540155628 0.3022883447175315 1.0 0.8757112965202937 7 P33121,Q15067 2 +Aurka activation by tpx2 0.4197071484344433 1.0304935228019356 0.3027783912703303 1.0 0.8757112965202937 30 O43805,Q7Z4H7,O95684,P17252,Q9H6D7,P53350,P06493 7 +Transcriptional regulation by mecp2 0.4760205152156904 1.0221597746838635 0.3067052857936976 1.0 0.8757112965202937 13 Q96GD4,Q14739 2 +Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 0.6082520839832553 1.0203626781185595 0.3075564874199745 1.0 0.8757112965202937 5 Q16512,P16104,P84243 3 +Mapk6 mapk4 signaling 0.3857219239164824 1.0017305404911252 0.3164737522364194 1.0 0.8771533896227272 52 Q99436,P06493,P28070,P49721 4 +Degradation of beta catenin by the destruction complex 0.3953515526944125 1.0010603701173646 0.31679762287995 1.0 0.8771533896227272 48 Q99436,P28070,P49841,P49721 4 +Mrna decay by 3 to 5 exoribonuclease 0.4563636485694059 0.9986539029166536 0.3179623784813166 1.0 0.8771533896227272 14 Q969T7,Q13868,Q9NQT4,Q15024 4 +Inhibition of dna recombination at telomere 0.4983162115148477 0.9877091555480902 0.3232951092872882 1.0 0.8771533896227272 11 P46100,Q9NYB0 2 +Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.4381646013108441 0.9862229034330824 0.3240237425557537 1.0 0.8771533896227272 19 P41440 1 +Sars cov 1 infection 0.4541763191476869 0.9860810924819348 0.3240933210553969 1.0 0.8771533896227272 14 P49840 1 +Prevention of phagosomal lysosomal fusion 0.6631656652628242 0.980614773456486 0.3267827462240609 1.0 0.8771533896227272 4 P20339 1 +Tcr signaling 0.393778006195751 0.9689262219897448 0.3325820012050022 1.0 0.8771533896227272 47 Q99436,P28070,P28074,P49721 4 +Polb dependent long patch base excision repair 0.6598022111866299 0.96765808589832 0.3332151574677997 1.0 0.8771533896227272 4 P09874 1 +G alpha 12 13 signalling events 0.540651369010979 0.9638040055619308 0.3351441980931762 1.0 0.8771533896227272 7 Q8N5V2,Q9UBI6,Q13464 3 +Metabolism of fat soluble vitamins 0.5943743044097918 0.9630581774417686 0.3355183283748153 1.0 0.8771533896227272 5 Q8N0U8,Q6NUM9 2 +Base excision repair ap site formation 0.5666641412226665 0.9610299641475204 0.3365371019151595 1.0 0.8771533896227272 6 Q9NYB0,P29372,P78549 3 +Nephrin family interactions 0.5305946599877944 0.9603403101508085 0.336883968664051 1.0 0.8771533896227272 8 O00459 1 +Recruitment of mitotic centrosome proteins and complexes 0.4099336590513116 0.9602780604760682 0.3369152889215274 1.0 0.8771533896227272 32 O43805,Q7Z4H7,P17252,Q9H6D7,P53350,P06493,P21127 7 +Nucleotide salvage 0.5291938883076706 0.953837690761412 0.3401658075481881 1.0 0.8771533896227272 8 P55263,P00813 2 +Activation of atr in response to replication stress 0.4361726901208543 0.9490371346638964 0.3426017256907254 1.0 0.8771533896227272 18 P24941 1 +Rhobtb gtpase cycle 0.4086142231134384 0.9483029386882954 0.342975255277206 1.0 0.8771533896227272 30 Q12792,Q5VTR2,P08670,P07910,Q8N684,Q13464,P38159,P62995,O43396 9 +Cd28 co stimulation 0.5250687681672797 0.9347091597534724 0.3499382050979376 1.0 0.8797697065625757 8 P07948,O00459 2 +Cellular senescence 0.3980745210394005 0.9328543570449216 0.3508951712821706 1.0 0.8797697065625757 42 P51812,P10412,Q92878,P07305,Q96DE5,Q15418,Q9NYB0,P49959,P20700,P16402,Q8IXK0,Q9UJX3,P16403,Q9UJX4,P24941,Q9Y6J0,Q9HCE1,P84243 18 +Cilium assembly 0.3571797897920926 0.930393998554009 0.3521671247432572 1.0 0.8799315757547505 59 Q92973,O43805,Q10713,Q7Z4H7,A6NIH7,P17252,Q9UPT5,Q9H6D7,P53350,P06493,O60645 11 +Vxpx cargo targeting to cilium 0.514078866853161 0.9266946160668866 0.3540851136905139 1.0 0.8799315757547505 9 Q9UPT5 1 +Insulin receptor recycling 0.4995236178770642 0.9215759670823672 0.3567497990947268 1.0 0.8799315757547505 10 Q9Y5K8,P36543 2 +Regulation of lipid metabolism by pparalpha 0.4394944876453741 0.9144508766598396 0.3604799787979722 1.0 0.8799315757547505 15 P23786,Q15067,P37268 3 +Sensing of dna double strand breaks 0.6457721188377443 0.9138480486472 0.3607966949525636 1.0 0.8799315757547505 4 P49959,P52292,Q92878 3 +Hedgehog off state 0.3733343488324836 0.91170143935265 0.3619259060822761 1.0 0.8799315757547505 53 Q99436,P28070,P49841,P49721 4 +Regulation of runx3 expression and activity 0.3990480743633058 0.9036898018808296 0.3661599082098155 1.0 0.8799315757547505 38 Q99436,P28070,P49721 3 +Rho gtpases activate cit 0.5180217230684865 0.9021117117524328 0.3669975280575339 1.0 0.8799315757547505 8 O14974,P60660,Q7Z406,P35580 4 +Sars cov 2 infection 0.3998897030169152 0.9004889347593309 0.3678601112888797 1.0 0.8799315757547505 24 P49840 1 +Epha mediated growth cone collapse 0.5076167253494206 0.8961515837903444 0.3701718100250377 1.0 0.8799315757547505 9 P07948,Q13464,Q7Z406,Q8N5V2,P60660,P35580 6 +Transcriptional activation of mitochondrial biogenesis 0.4802762608337865 0.8957499717642374 0.3703863146417658 1.0 0.8799315757547505 11 P48735 1 +Transport of bile salts and organic acids metal ions and amine compounds 0.5512014087838863 0.8944811481553608 0.3710645118811211 1.0 0.8799315757547505 6 Q8TAD4 1 +Rhoj gtpase cycle 0.4191278328860698 0.892132258222594 0.372322046327616 1.0 0.8799315757547505 20 Q8TAA9,O00459,P60953,P27105,Q6IAA8,Q15758,Q5T2T1,Q07960 8 +Ros and rns production in phagocytes 0.5062822214562983 0.8898565146192858 0.3735429361581206 1.0 0.8799315757547505 9 Q9Y5K8,P36543 2 +Ptk6 regulates proteins involved in rna processing 0.795487393080809 0.8882596026973291 0.3744011244276395 1.0 0.8799315757547505 3 O75525 1 +Organelle biogenesis and maintenance 0.3527341548618385 0.8847413371863239 0.3762961552640826 1.0 0.8799315757547505 89 Q92973,P00846,O60645,P06576,Q10713,O43805,Q7Z4H7,A6NIH7,O95684,P17252,Q9UPT5,Q9H6D7,P53350,P06493,P48735 15 +Factors involved in megakaryocyte development and platelet production 0.3888807841236044 0.8814772800984733 0.3780595458961571 1.0 0.8799315757547505 44 P45973,Q9NSK0,Q14185,P60953,Q9H0H5,Q8IWA4,P17252,P20339,Q92667,P24941,P84243 11 +Displacement of dna glycosylase by apex1 0.7907809735992237 0.8721157234951874 0.383145249206118 1.0 0.8799315757547505 3 P78549 1 +Mitochondrial protein import 0.3968209749916708 0.8699358333215174 0.3843354715612628 1.0 0.8799315757547505 35 Q5JRX3,Q9NS69,Q99595,P06576,P21796,Q10713,O60830 7 +Cdt1 association with the cdc6 orc origin complex 0.3907241761277405 0.8625542871889178 0.3883825730704915 1.0 0.8799315757547505 41 Q99436,P28070,P28074,P49721 4 +Alpha oxidation of phytanate 0.6322010458532581 0.8622223517302107 0.3885651720515464 1.0 0.8799315757547505 4 Q9BY49 1 +Negative regulation of notch4 signaling 0.3915551460219529 0.8600681138827346 0.3897514967454007 1.0 0.8799315757547505 40 Q99436,P28070,P49721 3 +Degradation of dvl 0.3923667503838883 0.8583860029424916 0.3906793539468902 1.0 0.8799315757547505 39 Q99436,P28070,P49721 3 +Hdr through mmej alt nhej 0.5426055376378811 0.857723907145073 0.3910449356324632 1.0 0.8799315757547505 6 P09874,P49959 2 +Generation of second messenger molecules 0.6310102305989724 0.8577150639982417 0.3910498198548018 1.0 0.8799315757547505 4 Q16512,Q8N8S7 2 +Anchoring of the basal body to the plasma membrane 0.3961254170845388 0.8562970105086003 0.3918335144358289 1.0 0.8799315757547505 31 O43805,Q7Z4H7,P17252,Q9H6D7,P53350,P06493 6 +Degradation of axin 0.3925029663004468 0.8523508055567608 0.3940194155386098 1.0 0.8799315757547505 38 Q99436,P28070,P49721 3 +Cross presentation of soluble exogenous antigens endosomes 0.3925029663004468 0.8523508055567608 0.3940194155386098 1.0 0.8799315757547505 38 Q99436,P28070,P49721 3 +Telomere maintenance 0.3938883773239489 0.8518075373265551 0.3943209222762642 1.0 0.8799315757547505 36 P24941,P41440 2 +Dna replication 0.350202733788459 0.844568220956601 0.3983519585121891 1.0 0.8806903298290087 90 P28074,P28070,P41440,P24941,P49721,Q99436 6 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.3925583088841814 0.8438271232644007 0.3987660165868369 1.0 0.8806903298290087 25 Q13126 1 +Hur elavl1 binds and stabilizes mrna 0.5140580548182478 0.8436621986156801 0.39885819673695 1.0 0.8806903298290087 7 P17252 1 +Asymmetric localization of pcp proteins 0.3895621998757818 0.8362558141906722 0.4030110050049638 1.0 0.8839690253745132 39 Q99436,P28070,P49721 3 +Stabilization of p53 0.3895621998757819 0.8362558141906722 0.4030110050049638 1.0 0.8839690253745132 39 Q99436,P28070,P49721 3 +Metabolism of polyamines 0.3885111587927522 0.8358170646227646 0.4032578249173084 1.0 0.8839690253745132 40 Q99436,P28070,P28074,P49721 4 +Rhog gtpase cycle 0.3916859433834537 0.8349025211234969 0.4037725951638626 1.0 0.8839690253745132 36 P61604,Q8TAA9,Q16718,Q14185,P60953,P51149,Q86UP2,Q14126,P34897,Q86XL3,Q9BSJ8,Q14739,Q5T2T1,Q6IAA8,O15173,P50402,Q07960 17 +Heme degradation 0.6234315387044893 0.8291239149722719 0.4070342925320094 1.0 0.8879720889234776 4 P09601,P30519 2 +Visual phototransduction 0.4926935363425089 0.8260388972393942 0.4087820271336277 1.0 0.8888398964587934 9 P49354,P17252 2 +Akt phosphorylates targets in the cytosol 0.7770338046809244 0.825303426221843 0.4091993471449344 1.0 0.8888398964587934 3 P49840 1 +B wich complex positively regulates rrna expression 0.4186775301843248 0.8228508405816778 0.4105928210441929 1.0 0.8904731806395935 17 O00159,P16104,P49841,O15446,Q9H9Y6,P84243 6 +Formation of atp by chemiosmotic coupling 0.4784552890810081 0.8189268810904591 0.4128281321050628 1.0 0.891143775057274 10 P00846 1 +Signaling by notch4 0.3832705287520135 0.8122703906398071 0.4166364966669418 1.0 0.892684791120434 42 Q99436,P28070,P49721 3 +Regulation of plk1 activity at g2 m transition 0.3892167888580072 0.8120899063321487 0.4167400445543432 1.0 0.892684791120434 35 Q96CV9,O43805,Q7Z4H7,P17252,Q9H6D7,P53350,P06493 7 +Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 0.7667210440456724 0.8076782385428913 0.41927583414562 1.0 0.892684791120434 2 Q15750 1 +Activated tak1 mediates p38 mapk activation 0.7667210440456724 0.8076782385428913 0.41927583414562 1.0 0.892684791120434 2 Q15750 1 +Platelet calcium homeostasis 0.6170421155729683 0.8051546644967932 0.4207304341865976 1.0 0.892684791120434 4 P20020,Q13586,P16615 3 +Noncanonical activation of notch3 0.7657422512234792 0.8040934370135057 0.4213430145991017 1.0 0.892684791120434 2 P67809 1 +Notch3 activation and transmission of signal to the nucleus 0.7657422512234792 0.8040934370135057 0.4213430145991017 1.0 0.892684791120434 2 P67809 1 +The phototransduction cascade 0.5551948485641318 0.803502129168934 0.4216845666116438 1.0 0.892684791120434 5 P49354 1 +Resolution of sister chromatid cohesion 0.3379310138100121 0.803124292024187 0.4219028983969775 1.0 0.892684791120434 61 Q96GD4,O00139,Q12769,Q8WYP5,P49454,Q53HL2,Q8WVM7,Q29RF7,Q9BW27,Q6P1K2,P53350,P06493,Q8NFH4,Q92674,Q9NQS7 15 +Transferrin endocytosis and recycling 0.4608848196586123 0.7979856739936838 0.4248788036799213 1.0 0.8939329948960888 11 Q9Y5K8,P36543 2 +Anti inflammatory response favouring leishmania parasite infection 0.4346092868877844 0.795674926661411 0.4262210039970973 1.0 0.8939329948960888 13 Q9UBI6,P07948,P19174,Q9Y3E5,P35579,P17252,P13861,P63218,P04899 9 +Regulation of ras by gaps 0.3831506819273293 0.7932873555500822 0.4276104220545151 1.0 0.8939329948960888 40 Q99436,P28070,P49721 3 +Sumoylation of transcription factors 0.6122068991179074 0.7871046481654668 0.4312206086233314 1.0 0.8939329948960888 4 O75928,Q13330 2 +Cdc6 association with the orc origin complex 0.765216116381015 0.7855119157967926 0.4321534867257028 1.0 0.8939329948960888 3 Q9Y619 1 +Creb phosphorylation 0.7595432300163059 0.7814839472797502 0.4345179145094344 1.0 0.8964913327267506 2 Q15418 1 +Hedgehog on state 0.3769684282210397 0.7715751894093141 0.4403660736648209 1.0 0.8964913327267506 43 Q99436,P28070,P49721 3 +Extension of telomeres 0.3828044269626822 0.7666660190894653 0.4432801122096834 1.0 0.8964913327267506 27 P41440 1 +Interleukin 12 signaling 0.3796630429647692 0.7444743713077088 0.4565895404480695 1.0 0.905351831631315 27 P07237,P60953,Q13126,P52597,P14174,P22626 6 +Signaling by ptk6 0.4358388117741574 0.7337571331132823 0.4630967707949707 1.0 0.9143361562779792 12 O75525,P24941,Q14185 3 +Chromosome maintenance 0.3734642204012439 0.7247173680213352 0.468625437907439 1.0 0.9200188692699668 41 P24941,P41440 2 +Synthesis of prostaglandins pg and thromboxanes tx 0.594067113276589 0.7201528872741282 0.4714308676596086 1.0 0.9205594492283318 4 Q8N8N7 1 +Dna damage bypass 0.3874048661612019 0.7158668857548321 0.4740735473312616 1.0 0.9205594492283318 21 P41440 1 +E2f mediated regulation of dna replication 0.4322864895751989 0.7156079756591105 0.4742334474706895 1.0 0.9205594492283318 12 P06493 1 +Apoptotic cleavage of cellular proteins 0.3946253224466608 0.7150394195149448 0.4745846857007474 1.0 0.9205594492283318 19 P49354,P35611,P08670,Q15149,Q13464,Q14126,P20700,P51572,P02545,P25054,Q13813,Q16625 12 +Auf1 hnrnp d0 binds and destabilizes mrna 0.3697585088922326 0.7132560295536312 0.475687340936616 1.0 0.9205594492283318 43 P28070,Q99436,P49721 3 +Dna methylation 0.5324191301822412 0.7130021828346532 0.4758444064029183 1.0 0.9205594492283318 5 P84243 1 +Egfr downregulation 0.4842075682636169 0.711361248017849 0.4768604063365782 1.0 0.9205594492283318 7 Q92783,Q9Y6I3,P60953 3 +Signaling by hedgehog 0.3378861975211495 0.7075337207331884 0.479234864939267 1.0 0.9230955203909748 58 Q99436,P28070,P49841,P49721 4 +Signaling by vegf 0.3732326074588764 0.6993382794039051 0.4843406498581446 1.0 0.9230955203909748 27 Q14185,Q13685,O00459,Q13464,P17252,Q96F07,Q9UQB8 7 +Plasma lipoprotein assembly remodeling and clearance 0.3973173576367005 0.6969782893940284 0.485816380797708 1.0 0.9230955203909748 17 P35610,P07237,O15118,P17252,Q8WTV0 5 +Rhof gtpase cycle 0.3957814921062287 0.6880615745940486 0.4914140067904542 1.0 0.929267903848979 17 Q8TAA9,Q07960,O00459,P20700,Q9BSJ8,P80723 6 +Aquaporin mediated transport 0.4771289262434278 0.6805486665801419 0.4961571178283404 1.0 0.9338942141349644 7 Q9UBI6,P17252,Q99797 3 +Fc epsilon receptor fceri signaling 0.3480485175104041 0.680025488866069 0.4964883218585616 1.0 0.9338942141349644 53 Q99436,P28070,P28074,P49721 4 +Peroxisomal protein import 0.3817433796427845 0.679925202560396 0.4965518227893399 1.0 0.9338942141349644 21 P34913,Q9BY49,Q15067,O75381,P39210,O15254 6 +Rhobtb2 gtpase cycle 0.383565312827381 0.6681006458860959 0.5040693495847315 1.0 0.9390899930249316 20 O43396,P38159 2 +Tcf dependent signaling in response to wnt 0.3242335744288289 0.6632602239068096 0.5071639066588247 1.0 0.9390899930249316 61 Q99436,P28070,P49841,P49721 4 +Neurotransmitter clearance 0.7259380097879276 0.6621145536888452 0.5078978093283453 1.0 0.9390899930249316 2 P05091 1 +Cristae formation 0.3858149343593425 0.6617356269436627 0.5081406678682012 1.0 0.9390899930249316 19 P00846,P06576 2 +Trafficking of myristoylated proteins to the cilium 0.7261881770495198 0.6577008776996197 0.5107303582700988 1.0 0.9390899930249316 3 A6NIH7 1 +Senescence associated secretory phenotype sasp 0.3780679725749707 0.656762323386066 0.5113337536471574 1.0 0.9390899930249316 21 P51812,Q15418,Q96DE5,Q9UJX3,Q9UJX4,P24941,P84243 7 +Dcc mediated attractive signaling 0.7258021996950326 0.656468661651187 0.5115226248348501 1.0 0.9390899930249316 3 Q14185 1 +Uch proteinases 0.3567717756432086 0.653655316380197 0.5133338972996979 1.0 0.9390899930249316 47 P28074,P28070,Q8NB78,P49721,Q99436 5 +Suppression of phagosomal maturation 0.4701424571019323 0.6503972809387589 0.5154356332251657 1.0 0.9405986057666444 7 P20339 1 +Cellular response to hypoxia 0.3621820559704771 0.629777229521051 0.528840345598319 1.0 0.9509106129711216 40 Q99436,P28070,P49721 3 +Regulation of hmox1 expression and activity 0.3537538719124423 0.6286507302811963 0.5295777405091333 1.0 0.9509106129711216 47 Q99436,P28070,P49721 3 +Dna double strand break response 0.3849702307621531 0.6259187437446686 0.5313682395982464 1.0 0.9511737840019434 17 O60934,P04637,Q14676,Q92878,P16104,P61088,P49959,Q9NWV8,P52292,O96028 10 +Transcriptional regulation by runx3 0.3587670586192965 0.6256047720065362 0.5315742079926835 1.0 0.9511737840019434 43 Q99436,P28070,P28074,P49721 4 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.3571480247878124 0.6220926644479615 0.533880938190828 1.0 0.9511737840019434 44 Q99436,P28070,P49721 3 +Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 0.5658370461738507 0.6188550493801903 0.5360118531456666 1.0 0.9511737840019434 4 P42126 1 +Mitochondrial calcium ion transport 0.383616220316768 0.6182191734711845 0.5364308728687135 1.0 0.9511737840019434 17 P21796,Q10713,Q8WWC4,Q9Y4W6 4 +Rho gtpases activate paks 0.4223804131243819 0.6094195058104909 0.5422464120295567 1.0 0.9511737840019434 11 Q14247,P60953,P35579,O14974,Q7Z406,P60660,P35580 7 +Mitochondrial biogenesis 0.361383545728384 0.6071826592821856 0.5437296989043101 1.0 0.9511737840019434 30 P48735,P00846,P06576 3 +Degradation of gli1 by the proteasome 0.3559830664754605 0.6036880530584628 0.5460510584860729 1.0 0.9511737840019434 43 Q99436,P28070,P49721 3 +Cell cycle checkpoints 0.3754841217376633 0.601534733581426 0.5474838847082202 1.0 0.9511737840019434 138 Q96GD4,Q9Y3B8,P28074,Q9Y619,Q8WYP5,P28070,Q9UQ84,Q6P1K2,P53350,P06493,P24941,P49721,Q99436 13 +Fgfr2 alternative splicing 0.4095266693099971 0.6014479329196949 0.5475416811365654 1.0 0.9511737840019434 12 O15514,P52272,P31943,P52597,P09651,P31483,Q09161 7 +Regulation of pten stability and activity 0.3561675077288725 0.5970627833072601 0.5504654643131457 1.0 0.95265317447898 42 Q99436,P28070,P49721 3 +Recruitment of numa to mitotic centrosomes 0.3601454681160129 0.5960546956907972 0.551138688117162 1.0 0.95265317447898 35 O43805,Q7Z4H7,P17252,Q9H6D7,P53350,P06493 6 +Rhoc gtpase cycle 0.359503812949795 0.5940957690407827 0.5524480605633122 1.0 0.9527749371393908 30 Q9H0H5,Q13464,P28288,Q14739,P41440,Q07960 6 +Small interfering rna sirna biogenesis 0.7058937828141973 0.5938955044067004 0.5525820060498627 1.0 0.9527749371393908 3 Q15631 1 +Carnitine metabolism 0.5001672621710042 0.5890941071449366 0.5557981462405166 1.0 0.9559452626788564 5 O43772 1 +Fceri mediated nf kb activation 0.3538562394786148 0.5870318603126081 0.5571823091767345 1.0 0.956047069115123 43 Q99436,P28070,P49721 3 +Cargo trafficking to the periciliary membrane 0.3702244019081746 0.5869535147188943 0.5572349271715666 1.0 0.956047069115123 20 O60645,Q9UPT5,A6NIH7 3 +Dectin 1 mediated noncanonical nf kb signaling 0.3533427638002568 0.5830223372785559 0.559878263212144 1.0 0.9582133530683796 43 Q99436,P28070,P49721 3 +Tnfr2 non canonical nf kb pathway 0.3533427638002568 0.5830223372785559 0.559878263212144 1.0 0.9582133530683796 43 Q99436,P28070,P49721 3 +Unfolded protein response upr 0.3567301546396906 0.5788547060952742 0.5626872144753334 1.0 0.9618347951869 38 Q13217,Q13868,P49840,O14773,Q15084,Q15024,Q9NWM8,Q9NQT4 8 +Copi dependent golgi to er retrograde traffic 0.3489134727000722 0.5770837602013631 0.5638828742554562 1.0 0.9626930251741368 46 Q8N6H7,Q9NSK0,Q9H0H5,O15260 4 +Met activates ptk2 signaling 0.6985516263396458 0.5713397610459927 0.5677693541541147 1.0 0.9669495258477436 3 P07942 1 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4345076028828516 0.562029411995168 0.5740959800976873 1.0 0.9694716948287796 9 Q14168,Q92796 2 +Transcriptional regulation by tp53 0.3376487459665266 0.5604437625423022 0.5751767886223478 1.0 0.9694716948287796 103 Q96GD4,Q9Y3B8,Q14004,Q9UQ84,P06493,P24941 6 +Miscellaneous transport and binding events 0.4697750433107661 0.5580436665697435 0.5768145666162521 1.0 0.9694716948287796 6 Q8TDW0 1 +Kinesins 0.3707433216716005 0.5578527308193307 0.576944951736738 1.0 0.9694716948287796 18 Q9H0H5 1 +Interleukin 1 signaling 0.3455917475180961 0.5504346015128644 0.5820213213728902 1.0 0.9694716948287796 46 Q99436,P28070,P49721 3 +Rnd2 gtpase cycle 0.3726368505136006 0.5471129312750304 0.5843011487831418 1.0 0.9694716948287796 16 Q8TAA9,O00459,Q07065,P38159,O43396,Q07960 6 +Cd209 dc sign signaling 0.4876241058966909 0.5426282665696529 0.5873857728975542 1.0 0.9694716948287796 5 P17252 1 +Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.6889246059768512 0.542228088763319 0.5876613874782046 1.0 0.9694716948287796 3 Q8NB78 1 +Defective cftr causes cystic fibrosis 0.3473615280408384 0.5366750734167509 0.5914920769975842 1.0 0.9694716948287796 43 Q99436,P28070,P49721 3 +Abc transporter disorders 0.3473615280408383 0.5366750734167494 0.5914920769975853 1.0 0.9694716948287796 43 Q99436,P28070,P49721 3 +Glycerophospholipid biosynthesis 0.3474034764397844 0.5284477129890041 0.5971886288048833 1.0 0.9746377066628944 26 Q9NPH0,Q8NCC3,Q96N66,P48651 4 +Cytoprotection by hmox1 0.2972663182381392 0.5219393317545085 0.6017125720742871 1.0 0.9779590749872488 65 Q99436,P28070,P28074,P49721 4 +Plasma lipoprotein assembly 0.5330630312769986 0.5069781763402097 0.6121701312982828 1.0 0.9857217427401584 4 P07237 1 +Recognition and association of dna glycosylase with site containing an affected purine 0.4765486025381047 0.5025638336850986 0.615270962150817 1.0 0.9857753407463774 5 Q9NYB0,P29372 2 +Hedgehog ligand biogenesis 0.3438721019533647 0.4972565289332125 0.619008162640766 1.0 0.9857753407463774 41 Q99436,P28070,P49721 3 +Erythropoietin activates phospholipase c gamma plcg 0.6743882544861195 0.4924284700865826 0.6224164770333065 1.0 0.9859583469165089 2 P07948 1 +Trna modification in the mitochondrion 0.4733220213050353 0.4910768312374342 0.623372107552773 1.0 0.9859583469165089 5 O15091 1 +Inla mediated entry of listeria monocytogenes into host cells 0.673409461663945 0.4893983997207514 0.6245596688029196 1.0 0.9862216385647924 2 O60716 1 +Regulation of insulin secretion 0.3698576349843259 0.4634351396591387 0.6430524958614261 1.0 0.993593730401348 13 P11166,Q9UBI6,P17252 3 +Plasma lipoprotein clearance 0.3777443060189839 0.4502498385454721 0.6525303036402528 1.0 0.993593730401348 12 O15118,Q8WTV0,P35610 3 +Clec7a dectin 1 signaling 0.3301272620852705 0.4495948360644081 0.6530026122479538 1.0 0.993593730401348 48 Q99436,P28070,P49721 3 +Sphingolipid metabolism 0.3355899269320149 0.4461959470242934 0.6554557103250911 1.0 0.993593730401348 27 Q06136,Q96G23 2 +Glucagon like peptide 1 glp1 regulates insulin secretion 0.4203306906747796 0.4453449955107079 0.6560704556755674 1.0 0.993593730401348 7 Q9UBI6,P17252 2 +Interleukin 12 family signaling 0.3370252825754065 0.4422454298153024 0.6583116148798509 1.0 0.993593730401348 30 Q13126 1 +Metabolism of steroids 0.3351786602710519 0.438631123304434 0.6609288416475456 1.0 0.993593730401348 42 P37268,Q15392,Q16850,Q9BWD1,P30536,Q14739,Q9UBM7,Q9H4L5,Q15126 9 +Glucagon signaling in metabolic regulation 0.4371942536691758 0.4350316715489379 0.6635394386176732 1.0 0.993593730401348 6 Q9UBI6,P17252 2 +Vasopressin regulates renal water homeostasis via aquaporins 0.4371942536691758 0.4350316715489379 0.6635394386176732 1.0 0.993593730401348 6 Q9UBI6,P17252 2 +Translocation of slc2a4 glut4 to the plasma membrane 0.3369160012210432 0.4326127101166095 0.6652961541498235 1.0 0.993593730401348 35 O60645,Q9UPT5,Q9Y3B8 3 +Hs gag biosynthesis 0.6544861337683465 0.4324407902751396 0.6654210771166262 1.0 0.993593730401348 2 O94923 1 +Beta catenin independent wnt signaling 0.3095779035935861 0.4195600142531942 0.6748069041258586 1.0 0.993593730401348 57 Q99436,Q9UBI6,P28070,P49721 4 +Synthesis of pips at the er membrane 0.6492659053833503 0.4172973725772773 0.676460910085019 1.0 0.993593730401348 2 Q13614 1 +Regulation of mrna stability by proteins that bind au rich elements 0.2901827842210382 0.4167643442401415 0.6768507849611658 1.0 0.993593730401348 64 Q92973,P28074,Q13868,P28070,P49721,P17252,Q92530,Q15024,Q9NQT4,Q99436,Q01105 11 +Processing of smdt1 0.3699205190169919 0.4149442164723873 0.6781827400342486 1.0 0.993593730401348 12 Q10713,Q9Y4W6 2 +Activation of gene expression by srebf srebp 0.3481607782481241 0.4129874897634503 0.6796157794899265 1.0 0.993593730401348 14 Q16850,P37268,Q15126 3 +Establishment of sister chromatid cohesion 0.4112513587756459 0.4103726554882628 0.6815326020345605 1.0 0.993593730401348 7 Q29RF7,Q8N3U4,Q8WVM7 3 +Clec7a dectin 1 induces nfat activation 0.6460032626427337 0.4079637546638007 0.6833002851062553 1.0 0.993593730401348 2 Q08209 1 +Signaling by flt3 fusion proteins 0.5007549520248831 0.4045228674312808 0.6858282656403247 1.0 0.993593730401348 4 Q9UBW7 1 +Role of lat2 ntal lab on calcium mobilization 0.6401846969413959 0.4041362163312255 0.6861125543169986 1.0 0.993593730401348 3 O00459 1 +Mapk family signaling cascades 0.3109080240924639 0.4033376634266679 0.6866998380634972 1.0 0.993593730401348 92 P49354,Q96S59,P28074,O00459,P28070,O60725,P06493,P49721,Q99436 9 +Metabolism of lipids 0.3831317212447467 0.4001164693395154 0.6890707344177553 1.0 0.9951407708381524 170 Q16836,O00459,Q15067,O43772,P37268,P23786,P33121,Q8N8N7,Q14914,Q9UBM7,Q9H4L5,O15254,P42126,Q9NPH0,Q06136,Q15165,Q8NCC3,Q8IVS2,Q16850,O95864,O14975,Q14739,Q9H7Z7,Q96G23,Q9BY49,P48651,Q15392,P27544,P30536,Q16880,Q9UMR5,P34913,P35610,Q96N66,Q10713,Q9BWD1,P17252,P09960,P20339,Q15126 40 +Synthesis of bile acids and bile salts 0.4080422717476644 0.3982287763230341 0.6904615559298124 1.0 0.9951407708381524 7 Q9H4L5 1 +Bile acid and bile salt metabolism 0.4080422717476644 0.3982287763230341 0.6904615559298124 1.0 0.9951407708381524 7 Q9H4L5 1 +Apoptotic execution phase 0.3298799466360622 0.3961325266407895 0.6920072640580288 1.0 0.9951407708381524 30 P49354,P10412,P08670,P07305,Q13464,P20700,P16402,P16403,P25054,Q16625 10 +Adora2b mediated anti inflammatory cytokines production 0.3939576067578135 0.393279478053967 0.6941130737586614 1.0 0.9962810124758922 9 Q9UBI6,P17252,P13861,P63218,P04899 5 +Mitochondrial trna aminoacylation 0.3376561920596162 0.3878223011579897 0.6981475407678313 1.0 0.9962810124758922 19 Q9HA77,Q96GW9,Q9NSE4,Q5JTZ9,Q5ST30 5 +Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.4928340233341022 0.3808195903381227 0.7033371216825139 1.0 0.997172548411981 4 O14975 1 +Sema4d in semaphorin signaling 0.3966402273963215 0.3789011443870896 0.7047612743600022 1.0 0.9976631790637256 8 Q13464,Q7Z406,P60660,P35580,Q9NWH9 5 +Interleukin 1 family signaling 0.3203435103106887 0.3738356033991064 0.7085266291641168 1.0 0.9984111282028368 48 Q99436,P28070,P49721 3 +Tp53 regulates transcription of dna repair genes 0.3238087001992685 0.3704914995015883 0.7110163090840231 1.0 0.9990332610526576 23 Q14004 1 +Hiv transcription initiation 0.3880790838989466 0.3703423507946777 0.7111274221325834 1.0 0.9990332610526576 9 Q92804 1 +Rho gtpases activate formins 0.3003822855797275 0.3596187747265955 0.7191322414664496 1.0 1.0 58 P35080,Q96GD4,Q12769,P60953,Q8WYP5,P49454,Q53HL2,Q9BW27,Q6P1K2,P53350,Q92674,Q9NQS7 12 +Signaling by notch 0.3099250485601145 0.3527922943273906 0.724244161052213 1.0 1.0 53 Q99436,P28070,P49721 3 +Transcriptional regulation by runx1 0.2814579187824126 0.3482000822833792 0.7276899259888758 1.0 1.0 70 P28074,P28070,P49721,Q99436,Q969G3 5 +Reduction of cytosolic ca levels 0.6168407310704977 0.344405671944218 0.7305412239012856 1.0 1.0 3 P20020,P16615 2 +Tight junction interactions 0.6182707993474623 0.3329350442943721 0.7391833155179077 1.0 1.0 2 Q8TEW0 1 +Miro gtpase cycle 0.4744341056703651 0.3281924306206896 0.7427661706733477 1.0 1.0 4 Q8IWA4,Q8IXI2 2 +Mitotic prometaphase 0.3016897098516093 0.3229418171696062 0.7467393060957392 1.0 1.0 91 Q12769,O95684,Q9BW27,P06493,O75935,O00139,O43805,Q7Z4H7,Q9NQS7,Q96GD4,Q8WYP5,P49454,P53350,Q29RF7,Q8NFH4,Q8WVM7,Q53HL2,Q96CS2,P17252,Q9H6D7,Q6P1K2,Q92674 22 +Antigen processing cross presentation 0.3091685868411247 0.3208357551495379 0.748334861910706 1.0 1.0 51 Q99436,P28070,P49721 3 +Signaling by egfr 0.3556974734970785 0.3159375637533313 0.7520498993304292 1.0 1.0 11 Q9Y6I3,Q92783,Q13685,P60953 4 +Sema4d induced cell migration and growth cone collapse 0.4020322970603527 0.3143659901478012 0.7532430836681863 1.0 1.0 6 P60660,Q13464,Q7Z406,P35580 4 +Pcp ce pathway 0.3082300253149257 0.3136652821023721 0.7537752717884463 1.0 1.0 51 Q99436,P28070,P49721 3 +Extra nuclear estrogen signaling 0.3364818577907095 0.312907722830979 0.7543507700399072 1.0 1.0 13 Q9UBI6 1 +Deubiquitination 0.2963322535392481 0.312151281130289 0.7549255554359027 1.0 1.0 87 P85037,Q96RU2,P28074,P21796,P28070,Q8NB78,P06493,Q96K76,P49721,Q99436 10 +Rna polymerase i transcription 0.318898882822224 0.3119023734692188 0.7551147186602349 1.0 1.0 21 P17480,O95983,P16104,Q13185,Q86YP4,Q8WXI9,O15446,Q12873,P84243 9 +Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 0.6091353996737257 0.310004624789056 0.756557439425114 1.0 1.0 2 Q96T60 1 +Transcription of the hiv genome 0.320071834041489 0.3069528753961129 0.7588792416942765 1.0 1.0 20 Q9H3P2,P29084,Q92804 3 +Transcriptional regulation by the ap 2 tfap2 family of transcription factors 0.3995426331264295 0.3063950491890583 0.7593038773977347 1.0 1.0 6 P35659,O95619,P06748,P46087,Q6PL18 5 +Nuclear envelope breakdown 0.3162642095973799 0.3053163738592967 0.7601252064027069 1.0 1.0 42 Q9BTX1,Q12769,P49790,Q8NFH5,Q8N1F7,P20700,P42167,Q9BW27,Q7Z3B4,Q99567,P06493,P50402,P12270,A8CG34,P53350,Q8NFH4,P14635,P17252,Q9Y2U8 19 +Activation of nmda receptors and postsynaptic events 0.311980550055576 0.3036508643856179 0.761393895895369 1.0 1.0 23 Q92796,O14936,P49593,Q15418,Q14168,P17252,P13861 7 +Signaling by pdgfr in disease 0.3982746224561082 0.3023672248270982 0.762372136905815 1.0 1.0 6 O00459 1 +Abortive elongation of hiv 1 transcript in the absence of tat 0.3668801274346113 0.2915909669106547 0.7705993828041795 1.0 1.0 9 Q9H3P2 1 +Formation of the early elongation complex 0.3489610402524536 0.2898266714675316 0.7719488423126211 1.0 1.0 11 Q9H3P2 1 +Hats acetylate histones 0.3061898151111754 0.2892467312223679 0.7723925730612409 1.0 1.0 24 Q9H0E3,Q9NV56,Q9UBU8 3 +Retrograde transport at the trans golgi network 0.3205457017200135 0.2868606808608859 0.7742189978553975 1.0 1.0 15 Q9Y2V7,P51151 2 +Nr1h2 and nr1h3 mediated signaling 0.4568375430651826 0.2813139737602244 0.7784695933972345 1.0 1.0 4 Q8NB78 1 +Ca2 pathway 0.3748551849162628 0.280244742309905 0.7792897419437772 1.0 1.0 7 Q9UBI6,Q08209,P17252,P63218,Q9HCE1 5 +Intra golgi traffic 0.3168860391039449 0.2723665950296082 0.7853401553842814 1.0 1.0 14 O95721,O95249,O00461,Q8TBA6,Q9Y2V7 5 +Nonhomologous end joining nhej 0.3165217300666335 0.269829574012693 0.7872913696475805 1.0 1.0 16 O95551,Q14676,Q92878,P16104,P61088,P49959,Q9NWV8,O96028,P12956 9 +C type lectin receptors clrs 0.2991047879074285 0.2681820285688959 0.7885592076029238 1.0 1.0 53 Q99436,P28070,P49721 3 +Vegfr2 mediated cell proliferation 0.4016448039332061 0.2631764196380695 0.7924146047455651 1.0 1.0 5 P17252,O43865,P19174 3 +Signaling by scf kit 0.3636581565481672 0.2611463909738487 0.793979617696775 1.0 1.0 8 P17252,O00459 2 +Mitotic telophase cytokinesis 0.3486741264323685 0.256411510026516 0.7976331011615281 1.0 1.0 10 P53350,Q29RF7,Q8WVM7 3 +Transcriptional regulation by e2f6 0.3613667443306965 0.2535726243132122 0.7998257481333992 1.0 1.0 8 P45973,Q9UBK9 2 +Intracellular signaling by second messengers 0.2921128505493534 0.2522362174069542 0.8008584854375238 1.0 1.0 89 P28074,P49840,P28070,P49841,P49721,Q99436 6 +E3 ubiquitin ligases ubiquitinate target proteins 0.3107472568696716 0.2450776984373692 0.8063962705110046 1.0 1.0 16 Q5VTR2,P04439,P61088,O75381,Q8N7H5,Q9BUN8 6 +Global genome nucleotide excision repair gg ner 0.3067246324806532 0.244841993512646 0.8065787771747199 1.0 1.0 33 P41440 1 +Rna polymerase i transcription initiation 0.3091360716486691 0.2383244290172476 0.8116294755165199 1.0 1.0 16 P17480,O95983,Q9H9Y6,Q86YP4,Q8WXI9,Q12873,O15446 7 +Phospholipid metabolism 0.3065465582269132 0.2364788976771447 0.8130610801891196 1.0 1.0 39 Q9NPH0,Q96N66,P48651,O00459,Q10713,Q8NCC3,P20339 7 +Fatty acyl coa biosynthesis 0.307969466163128 0.233477209726764 0.8153908645873971 1.0 1.0 16 Q9UMR5 1 +Regulation of signaling by cbl 0.3900420472661423 0.2322340262305078 0.8163562509735434 1.0 1.0 5 O00459 1 +Regulation of kit signaling 0.5633172089949006 0.2262867545814049 0.820978399545186 1.0 1.0 3 P17252 1 +P75 ntr receptor mediated signalling 0.3392347350461538 0.2240614747339073 0.8227094690742822 1.0 1.0 10 Q8N5V2,Q14344,Q9NY61 3 +Signaling by kit in disease 0.3841258868214294 0.2172006156035822 0.8280520049536557 1.0 1.0 5 O00459 1 +Mitotic spindle checkpoint 0.2832201543722285 0.2169968446824359 0.8282108039365292 1.0 1.0 58 Q96GD4,O00139,Q12769,Q8WYP5,P49454,Q96DE5,Q53HL2,Q9BW27,Q6P1K2,P53350,Q8NFH4,Q92674,Q9NQS7 13 +Meiotic synapsis 0.3039104634308321 0.2168957651261612 0.8282895779914214 1.0 1.0 16 Q8WXH0,P16104,Q9NYB0,Q8WVM7,P20700,Q9UH99,Q8N3U4 7 +Sting mediated induction of host immune responses 0.3689281426917202 0.2155698970869599 0.8293230227292077 1.0 1.0 6 P19474,P49959 2 +Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.3245005071017097 0.2022449254233058 0.8397252533132273 1.0 1.0 11 Q92973,Q9NQT4,Q15024 3 +Ksrp khsrp binds and destabilizes mrna 0.3243601689606407 0.2017775738769705 0.8400906143901679 1.0 1.0 11 Q13868,Q9NQT4,Q15024 3 +Dna repair 0.2908061167898986 0.1928834368819995 0.8470502569070271 1.0 1.0 94 Q15004,P09874,Q9NYB0,P20585,Q9UQ84,P41440,Q9NY27,P24941,P78549 9 +Rhoq gtpase cycle 0.2943800982379195 0.1923075474661741 0.8475013067175832 1.0 1.0 21 Q8TAA9,P60953,P27105,Q6IAA8,Q15758,Q5T2T1,Q07960 7 +Neddylation 0.2623620805816628 0.1889650684301921 0.8501201948632757 1.0 1.0 68 Q8NEZ5,P28070,Q99436,P49721 4 +Signaling by insulin receptor 0.2946180695997822 0.180651491397379 0.8566411364534621 1.0 1.0 16 Q9Y5K8,P36543,O00459 3 +Fcgr3a mediated il10 synthesis 0.3403116382965767 0.1749943578375551 0.8610840669725106 1.0 1.0 7 P17252,P07948 2 +Amyloid fiber formation 0.3391223736084971 0.1717358032354464 0.8636452370513754 1.0 1.0 7 P84243,Q9UJY4,Q92542 3 +Interleukin 3 interleukin 5 and gm csf signaling 0.3265026908431291 0.161999567112454 0.8713061947614327 1.0 1.0 9 P17252,O00459 2 +Ret signaling 0.3332835785917054 0.1561126854663934 0.875944199403986 1.0 1.0 7 O00459 1 +Mecp2 regulates transcription of neuronal ligands 0.5295269168025963 0.1518713325406973 0.879288419297741 1.0 1.0 2 Q96ST3 1 +Signaling by cytosolic fgfr1 fusion mutants 0.3271717905822251 0.1514086714106451 0.8796533495257328 1.0 1.0 8 O15164,Q9UBW7,O95684 3 +Apoptosis 0.2797265708634073 0.1421787630816306 0.8869388059705683 1.0 1.0 89 P49354,P10412,Q9Y3B8,P28074,P28070,Q16625,Q9NR28,P49721,Q99436 9 +Rhou gtpase cycle 0.2841276895318654 0.1403241020278837 0.8884039220615256 1.0 1.0 18 Q92783,Q8TAA9,O43396,O00459 4 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.3026315771800824 0.1346877401187317 0.8928587668271335 1.0 1.0 11 P09601,Q7L5D6,P50402,P46379 4 +Listeria monocytogenes entry into host cells 0.3197718680129826 0.1321740375730138 0.8948466359485236 1.0 1.0 8 Q92783,O60716,Q9NWH9,P42566 4 +Transcription of e2f targets under negative control by dream complex 0.5128874388254329 0.1285929455847025 0.8976797485692549 1.0 1.0 2 P11388 1 +Atf4 activates genes in response to endoplasmic reticulum stress 0.2998162846817424 0.1267891611345319 0.899107274662784 1.0 1.0 11 Q13868,Q9NQT4,Q15024 3 +Inactivation of cdc42 and rac1 0.5004345028618414 0.1250983961626841 0.9004456530000686 1.0 1.0 3 P60953 1 +Pten regulation 0.2553102620968473 0.1242332299255946 0.9011306123574792 1.0 1.0 65 P28070,Q99436,P49721 3 +Energy dependent regulation of mtor by lkb1 ampk 0.3410298666852008 0.1238564697350497 0.9014289195983004 1.0 1.0 5 Q9Y376,Q6IAA8 2 +Iron uptake and transport 0.279069229670286 0.1221228328955871 0.9028017391860788 1.0 1.0 18 P30519,Q9Y5K8,Q93050,P36543 4 +Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 0.5070146818923225 0.1211645790175143 0.9035606792183056 1.0 1.0 2 P12814 1 +Epigenetic regulation of gene expression 0.2862241006695442 0.1200038047589823 0.9044801339800332 1.0 1.0 42 Q9H0E3,P17480,O95983,O00159,P16104,Q13185,P49841,Q86YP4,O75446,Q8WXI9,O15446,Q12873,Q9H9Y6,P84243 14 +Beta oxidation of butanoyl coa to acetyl coa 0.3719567364931971 0.1103280906298448 0.9121491801455612 1.0 1.0 4 Q16836 1 +Rho gtpases activate rocks 0.3066197528794533 0.1096666087777274 0.9126737829795516 1.0 1.0 9 P35579,O14974,Q13464,Q7Z406,P60660,P35580 6 +Caspase mediated cleavage of cytoskeletal proteins 0.3325917863170688 0.1090261006115971 0.9131817884360692 1.0 1.0 5 Q13813,Q15149,P08670 3 +Atf6 atf6 alpha activates chaperones 0.4959216965742147 0.1082221328501745 0.9138194885882844 1.0 1.0 2 P14625 1 +Atf6 atf6 alpha activates chaperone genes 0.4959216965742147 0.1082221328501745 0.9138194885882844 1.0 1.0 2 P14625 1 +Fgfr1 mutant receptor activation 0.3059339790696992 0.1080077227151249 0.913989566209193 1.0 1.0 9 O15164,Q9UBW7,O95684 3 +Fceri mediated ca 2 mobilization 0.3308835724160537 0.1061626147400955 0.915453332388626 1.0 1.0 5 P07948,Q08209,P19174 3 +Regulation of innate immune responses to cytosolic dna 0.4830287206266224 0.104442112765436 0.916818504248604 1.0 1.0 3 P19474,Q9UJV9 2 +Cation coupled chloride cotransporters 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 1.0 2 Q9Y666 1 +Tbc rabgaps 0.269160881626069 0.0987998214237797 0.921297210284159 1.0 1.0 15 P61020,P20339,Q9UJY4,Q96CV9 4 +Nuclear envelope ne reassembly 0.2803122816648528 0.0944486095841515 0.9247528034868492 1.0 1.0 46 Q9BTX1,Q8WYP5,Q86XL3,Q14739,P06493,P53990,P50402 7 +Inlb mediated entry of listeria monocytogenes into host cell 0.3140819213444897 0.0907784617874973 0.9276686243802604 1.0 1.0 6 Q92783,P42566 2 +Ngf stimulated transcription 0.4727569331158148 0.0855699874643341 0.9318082574586166 1.0 1.0 2 Q14839 1 +Programmed cell death 0.2825728671674216 0.080417010754638 0.9359055980939236 1.0 1.0 99 P49354,P10412,Q9Y3B8,P28074,P28070,Q16625,Q9NR28,P41440,P49721,Q99436 10 +Signaling by fgfr1 in disease 0.2875592841675945 0.0793737791986533 0.936735323993821 1.0 1.0 10 O15164,Q9UBW7,O95684 3 +Sensory perception 0.26591293045426 0.0722362776065243 0.942413875216526 1.0 1.0 27 P49354,Q6NUM9,Q12792,O14936,P17252 5 +Robo receptors bind akap5 0.4478570573935975 0.0717668058484652 0.9427874897739354 1.0 1.0 3 P17252 1 +Nuclear pore complex npc disassembly 0.2694194748890322 0.0697767072076282 0.9443713869357186 1.0 1.0 30 Q9BTX1,Q12769,P12270,A8CG34,Q9BW27,P06493,Q8NFH4 7 +Beta oxidation of hexanoyl coa to butanoyl coa 0.3056160347307594 0.0691873388077153 0.9448405011246748 1.0 1.0 5 Q16836 1 +Rap1 signalling 0.3377138423686643 0.068679012525033 0.945245124329432 1.0 1.0 4 P17252 1 +Neurotransmitter receptors and postsynaptic signal transmission 0.2736966494325445 0.0672702654534417 0.9463665479824834 1.0 1.0 35 Q9UBI6,P53680,Q92796,O14936,Q14168,P17252 6 +Antigen activates b cell receptor bcr leading to generation of second messengers 0.3354110385989747 0.0664117187779324 0.947050040565892 1.0 1.0 4 P07948 1 +Netrin 1 signaling 0.2902641605888569 0.0664091319900347 0.9470520999776488 1.0 1.0 8 Q16512,P19174,Q14185,P60953 4 +Signaling by wnt 0.2681658590219338 0.0654001604899495 0.947855396302556 1.0 1.0 87 Q9UBI6,P28070,P49841,P49721,Q99436 5 +Beta oxidation of decanoyl coa to octanoyl coa coa 0.3019028120597228 0.0645842646299012 0.948505013557052 1.0 1.0 5 Q16836 1 +Beta oxidation of octanoyl coa to hexanoyl coa 0.3019028120597228 0.0645842646299012 0.948505013557052 1.0 1.0 5 Q16836 1 +Dscam interactions 0.4313213703099467 0.0580139215456896 0.9537375394140252 1.0 1.0 2 Q16512 1 +Sema4d mediated inhibition of cell attachment and migration 0.4313213703099393 0.0580139215456863 0.9537375394140276 1.0 1.0 2 Q9NWH9 1 +Parasite infection 0.2582615771039873 0.0570571950665774 0.9544996342304576 1.0 1.0 23 P07948,Q14185,O15511,Q9Y4I1,Q96F07,Q9UQB8 6 +Hemostasis 0.3041760204765695 0.0560091411829972 0.9553345249833018 1.0 1.0 124 Q9UBI6,Q9NSK0,O43852,O00459,Q9H0H5,Q8NBX0,P42785,Q9UNN8,P14174,P24941,P53985 11 +Beta oxidation of lauroyl coa to decanoyl coa coa 0.3234867408458102 0.0556749734654448 0.9556007368519271 1.0 1.0 4 Q16836 1 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.2760913270324566 0.0553059246028547 0.9558947422420578 1.0 1.0 10 Q9UJX3,Q96DE5 2 +Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 0.2639606148427499 0.0551978864764518 0.9559808127179188 1.0 1.0 12 Q03164,Q9HCE1,P84243 3 +Signaling by notch1 0.2917347272133328 0.05498922530046 0.9561470477702234 1.0 1.0 6 Q96J02,Q92769,Q13616,Q92542,Q13573 5 +Selective autophagy 0.2614188865279407 0.0544078292500263 0.9566102412565254 1.0 1.0 27 P21796,Q9NS69,P08670 3 +Free fatty acids regulate insulin secretion 0.4190600522193203 0.0530740752878588 0.9576728872551 1.0 1.0 3 O60488,P29992 2 +Signaling by notch1 pest domain mutants in cancer 0.291639451338991 0.0529219567209764 0.9577940899748534 1.0 1.0 5 Q92769,Q13616,Q13573,Q92542 4 +Ub specific processing proteases 0.2468995718801298 0.0515872259108903 0.9588575980337132 1.0 1.0 69 Q96RU2,P28074,P28070,Q96K76,P49721,Q99436 6 +Tak1 activates nfkb by phosphorylation and activation of ikks complex 0.317355338304513 0.0507847213735169 0.9594970657440376 1.0 1.0 4 Q15750 1 +Irf3 mediated induction of type i ifn 0.2873097801221566 0.0484566298082589 0.9613523282108728 1.0 1.0 5 P49959 1 +Sirt1 negatively regulates rrna expression 0.2872313747141524 0.0483781931609191 0.961414838288322 1.0 1.0 5 P84243 1 +Gastrin creb signalling pathway via pkc and mapk 0.285087961040075 0.0460005024389492 0.963309849446644 1.0 1.0 6 P17252,Q15418 2 +Acyl chain remodeling of cl 0.4043733681462202 0.0459259088322891 0.9633693036985282 1.0 1.0 3 Q6UWP7,P40939 2 +Diseases associated with o glycosylation of proteins 0.3536704730831899 0.0370014685096293 0.9704838348423768 1.0 1.0 2 Q14118 1 +Scavenging by class f receptors 0.2941560561541022 0.0358146536482147 0.9714301486417738 1.0 1.0 4 P27797,Q92598,Q9Y4L1 3 +Arms mediated activation 0.305709624796086 0.0339064439430034 0.9729517546208496 1.0 1.0 2 P31946 1 +Signaling by mras complex mutants 0.2988580750407841 0.0337180391610097 0.9731019939809082 1.0 1.0 2 P31946 1 +Deposition of new cenpa containing nucleosomes at the centromere 0.2698387327727314 0.0312592451934598 0.9750627921361624 1.0 1.0 8 P16104,Q92674,Q96T23,Q6IPU0 4 +Rho gtpase cycle 0.323865362602408 0.0310169484037859 0.9752560233039512 1.0 1.0 149 P08670,P60953,O00459,P07910,Q9H0H5,Q13464,A4D1P6,P41440,O15173,P50402,P61604,Q12792,Q5VTR2,Q96HY6,P30519,Q9BSJ8,Q14739,Q96F07,Q9UQB8,Q5T2T1,P80723,Q7Z6E9,Q8TAA9,Q14185,P34897,Q8N5V2,Q86XL3,P28288,Q6IAA8,Q92783,P06753,Q86UP2,Q07065,Q8N684,P38159,Q8N6H7,P62995,Q15758,O43396,Q9UH62,Q07960 41 +Negative regulation of met activity 0.2693878708512957 0.0279124779666133 0.9777319563435468 1.0 1.0 7 Q92783,P42566 2 +Dex h box helicases activate type i ifn and inflammatory cytokines production 0.3328981723237654 0.0276059189476581 0.9779764608283495 1.0 1.0 3 Q9H2U1,Q08211 2 +Disorders of transmembrane transporters 0.2523729979162088 0.0270610776462683 0.9784110189215696 1.0 1.0 77 Q9BTX1,P28070,P53985,P49721,Q99436 5 +Mitochondrial fatty acid beta oxidation of saturated fatty acids 0.2681032659052693 0.0261412240514164 0.979144696248492 1.0 1.0 7 Q16836,P40939 2 +Nuclear signaling by erbb4 0.2633812010443942 0.0236133967469837 0.9811609860725676 1.0 1.0 3 P61201,Q92542 2 +Leishmania infection 0.2638985920642535 0.0164583296635428 0.9868687456924852 1.0 1.0 38 Q9UBI6,P07948,Q14185,P60953,O15511,Q9Y4I1,P17252,P59998,Q9UQB8,Q96F07,P09601 11 +Mitochondrial translation 0.2489788725861881 0.0131357475698262 0.989519491218533 1.0 1.0 61 Q7Z7F7,Q9HD33,Q9NYK5,Q9NQ50,Q7Z7H8,Q9NRX2,Q92665,Q9BYD6,Q96EY7,Q9NX20,Q8TAE8,Q9Y291 12 +Eph ephrin mediated repulsion of cells 0.2251814444676076 0.0078823668256178 0.9937108463332976 1.0 1.0 14 P53680,P98172 2 +Nucleotide excision repair 0.2629023915715291 0.0045999482441397 0.996329785258846 1.0 1.0 43 P41440 1 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ab2e5fed7dbbdbd780cdc5c8b60c9e288dea7ce1 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of caspases through apoptosome mediated cleavage", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via dependence receptors in the absence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd22 mediated bcr regulation", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular hexose transport", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Common pathway of fibrin clot formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Dectin 2 family", "Defective cftr causes cystic fibrosis", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of base excision repair", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Electric transmission across gap junctions", "Elevation of cytosolic ca2 levels", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phosphoinositide 3 kinase pi3k", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Erythropoietin activates stat5", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acids bound to gpr40 ffar1 regulate insulin secretion", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr activation", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of cell cycle genes", "Foxo mediated transcription of cell death genes", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 processing", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Na cl dependent neurotransmitter transporters", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr regulates axonogenesis", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Ras signaling downstream of nf1 loss of function variants", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in bcr signaling", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of keratinocytes", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx1 regulates transcription of genes involved in interleukin signaling", "Runx1 regulates transcription of genes involved in wnt signaling", "Runx2 regulates bone development", "Runx2 regulates chondrocyte maturation", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates bcl2l11 bim transcription", "Runx3 regulates cdkn1a transcription", "Runx3 regulates immune response and cell migration", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgf beta receptor complex in cancer", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of immune response proteins", "Sumoylation of intracellular receptors", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 24 hydroxycholesterol", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc efflux and compartmentalization by the slc30 family", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3B", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATR", "ATRX", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDHA", "BCKDK", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRD1", "BRD2", "BRD4", "BSG", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "CAB39", "CABIN1", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC22", "CCDC59", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CDS2", "CENPF", "CENPI", "CENPP", "CERS1", "CERS2", "CETN2", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLINT1", "CLNS1A", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "COG4", "COG6", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPM1", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFNB1", "EFTUD2", "EHD1", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF2", "FAM114A2", "FAM3C", "FAM49B", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP14", "FKBP1A", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTA", "FNTB", "FOXK1", "FOXO3", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP2", "GTPBP3", "GUSB", "GYS1", "H1F0", "H2AFX", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAM3", "JUP", "KARS", "KAT7", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LRPPRC", "LRRC41", "LRRC8A", "LRRC8C", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LYN", "LYPLA1", "M6PR", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAN2A1", "MAN2B1", "MANF", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MAPRE1", "MARC1", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "METAP1", "METTL1", "MFAP1", "MFN1", "MFN2", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MIPEP", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MPV17", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO5A", "MYO6", "NAA35", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NARS2", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEK9", "NELFA", "NELFCD", "NELFE", "NF1", "NFKB2", "NGEF", "NHLRC2", "NHP2", "NIP7", "NISCH", "NIT2", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PAK4", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF5A", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUS1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP5", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIOX2", "RIPK1", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP7A", "RRP8", "RRP9", "RSF1", "RSU1", "RTCB", "RTF1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMDT1", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX17", "STX18", "STX3", "STX4", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SYMPK", "SYNE2", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAP2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED10", "TMED5", "TMED7", "TMED9", "TMEM30A", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMX3", "TNPO1", "TOLLIP", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRMT10C", "TRMT11", "TRMT112", "TRMT61A", "TRRAP", "TSFM", "TSG101", "TSN", "TSPO", "TSR1", "TST", "TSTA3", "TTC21B", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS25", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WBP11", "WDCP", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YEATS4", "YIF1A", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZCRB1", "ZFYVE16", "ZMYM2", "ZNF512B", "ZNF638", "ZW10"], "leading_proteins": ["AAMP", "AARS2", "AATF", "ABCB1", "ABCC4", "ABCD3", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACSL4", "ACTN1", "ADA", "ADD1", "ADK", "AFG3L2", "AHCTF1", "AHCYL1", "AKAP1", "ALDH1B1", "ALDH2", "ANAPC16", "ANAPC5", "ANAPC7", "ANKLE2", "ANXA6", "AP2S1", "APC", "ARFGAP2", "ARHGAP1", "ARMCX3", "ARPC4", "ARPC5", "ATAD2", "ATP2A2", "ATP2B1", "ATP5B", "ATP6", "ATP6V0A1", "ATP6V1D", "ATP6V1E1", "ATRX", "AURKB", "BABAM1", "BAG6", "BAIAP2", "BASP1", "BCAP31", "CAB39", "CABIN1", "CALR", "CALU", "CARS2", "CASK", "CBX3", "CBX5", "CCNB1", "CD3EAP", "CDC42", "CDCA8", "CDK1", "CDK11B", "CDK13", "CDK2", "CENPF", "CENPI", "CENPP", "CERS1", "CERS2", "CHD3", "CHD4", "CKAP4", "COG6", "COPS2", "CPSF7", "CPT2", "CRTAP", "CTNND1", "CTTN", "CUL1", "CYFIP2", "CYP51A1", "DAG1", "DCTN3", "DDRGK1", "DDX41", "DEK", "DERL1", "DHCR24", "DHCR7", "DHX36", "DHX9", "DIABLO", "DLG3", "DNAJC3", "DOCK1", "DOHH", "DSG2", "ECE1", "ECI1", "EFNB1", "EMD", "ENAH", "EPHX1", "EPHX2", "EPN1", "EPS15", "ESYT1", "EXO1", "EXOC3", "EXOC7", "EXOSC2", "EXOSC5", "EXOSC7", "FADS2", "FBXO22", "FDFT1", "FECH", "FGFR1OP", "FKBP14", "FN3KRP", "FNTA", "FOXK1", "GADD45GIP1", "GATAD2A", "GATAD2B", "GET4", "GGA2", "GLCE", "GNA11", "GNA13", "GNAI2", "GNG12", "GNG5", "GOLGA5", "GOLIM4", "GOSR1", "GSK3A", "GSK3B", "GTF2E2", "H1F0", "H2AFX", "H3-3A*", "HADH", "HADHA", "HAUS1", "HAUS4", "HAUS6", "HDAC2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HLA-A", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPF", "HNRNPH1", "HNRNPM", "HSP90B1", "HSPE1", "HSPH1", "HYOU1", 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0000000000000000000000000000000000000000..edac058168caeee3e95b778860f3e0e13cd39970 --- /dev/null +++ b/msigdb_wp/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f55cd2a116527fadb902b919dd02d370f35ab322d13565a83770cab7175882ae +size 102063 diff --git a/msigdb_wp/df_merge.tsv b/msigdb_wp/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0f2ba2139b60264866caf56f7a454a9514d91c85 --- /dev/null +++ b/msigdb_wp/df_merge.tsv @@ -0,0 +1,31 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Dna irdamage and cellular response via atr 4 31 2.601731873322294 0.009275433873408 11.368932038834952 35.29854368932039 -0.5571161533496566 0.5286960221336726 6.506516958951914 4.2335573207288775 0.9558756700654956 0.346850563426156 0.00026096311242 0.0059462173176447 0.0065863767611137 0.0386631533679294 0.1700618733952761 +Type i collagen synthesis in the context of osteogenesis imperfecta 4 12 2.528437326435569 0.0114571539998256 3.929611650485437 12.026699029126211 0.5177909587737206 0.4899443091771766 2.065057615656466 0.7083179697775124 0.9693193629839164 0.3218513942404959 0.0393012238682757 0.0058373227860703 0.0224191931510111 0.0024379570615939 0.0052134507581354 +Mitochondrial long chain fatty acid betaoxidation 5 14 2.469131995806684 0.0135441248584624 3.349514563106796 13.533980582524272 0.7147062657958151 0.3986109248220331 2.228276960109081 1.0526483843060723 1.0135677936233438 0.2846338064127241 1.0 0.0742352733278267 0.144637307685789 0.0004862334359502 6.703246650942136e-05 +Mirna regulation of dna damage response 3 21 2.464056604197262 0.0137374414758077 6.997572815533981 23.76941747572815 -0.0927742871867072 0.6297630627489007 3.799909801182797 3.3700186756541433 0.7986845515233213 0.2977741953481899 0.005271608704837 0.0038595506966638 0.0038034373632918 0.0756483536674149 0.2160232841208998 +Dna damage response 3 20 2.43822976391747 0.0147593895116939 6.825242718446602 22.76941747572815 -0.1047399916281437 0.6179341114552384 3.624825899979946 3.3700186756541433 0.8102402020510112 0.2962122153795926 0.0049642787567718 0.0035377598965085 0.0034028502394037 0.0691718370159023 0.1985748090604032 +Ketogenesis and ketolysis 3 6 2.371778734461613 0.0177026884738962 1.8349514563106797 5.844660194174757 1.1440476930797234 0.2688274513424756 1.082491618646365 0.8448275696235764 0.860272390139093 0.2373824405295798 1.0 0.0331691185540615 0.0018987369599165 1.1110147517061663e-05 0.0001708540892308 +Dna mismatch repair 1 16 2.3634617888275997 0.0181050936270743 5.160194174757281 19.174757281553397 0.1547408857460915 0.5270932325531026 3.4632001533411247 1.960419929584235 1.0139907215610702 0.3153217325311915 0.0425098423004131 0.0068317681715133 0.0260710687649276 0.1300982938321277 0.3621483333283614 +Cholesterol metabolism with bloch and kandutschrussell pathways 9 21 2.3627125052778983 0.0181417371177652 7.092233009708738 23.070388349514563 1.3045876527781233 0.2885598195159411 3.1892169450204397 2.132138915277104 1.1515799969949023 0.3088028425519339 1.0 1.0 0.0498890213657128 2.226230744371199e-06 7.06610764140417e-06 +Influence of laminopathies on wnt signaling 5 11 2.361175000788707 0.0182171317341384 2.929611650485437 10.199029126213592 1.172665957836072 0.274405530989148 1.5096443497648335 1.3031697834850824 0.8784257604250459 0.2713478851839423 1.0 0.134742527043449 0.0029806631250197 0.0056128198685199 0.0027845492980534 +Neural crest differentiation 1 8 2.358465668877872 0.0183506570904188 2.121359223300971 8.480582524271844 0.2184651498610498 0.5347394603612715 2.120136947648397 1.523954886345698 0.8663287650790108 0.2803232757223193 1.0 0.0335548880884004 0.1151189883762866 0.4288192611001937 0.795813225928823 +Atm signaling pathway 1 13 2.3557753451397274 0.0184840926008467 5.725728155339806 14.978155339805824 -0.4845531915333449 0.565875901017388 3.04895624411497 2.0519960670928907 0.732253277081457 0.2994249617469091 0.0016839157720017 0.0135379522122687 0.0498890213657128 0.2256009180273313 0.2668248172965894 +Vitamin a and carotenoid metabolism 1 5 2.2484507334713686 0.0245474632407418 1.0606796116504855 4.106796116504855 0.9332890102257668 0.3070288768360753 0.8805930946368925 1.0255249317378814 1.0615219291263185 0.2652373693874932 1.0 0.0032958763634803 0.012905013470629 0.0693365470158766 0.2166689846253057 +Statin inhibition of cholesterol production 2 5 2.2321531233094305 0.0256048443937793 2.0315533980582523 5.029126213592233 1.044092701346018 0.2144191485801186 1.2890406286437517 1.2084356467042294 1.2621579412510306 0.2395890160394713 1.0 0.0652597674910206 0.1277572387780678 0.0041946485896371 0.0277461310389573 +Omega3 omega6 fatty acid synthesis 3 6 2.220405128833508 0.0263912792148657 2.186893203883495 5.679611650485437 0.6147861513210825 0.4189854893383595 1.4636445594342842 0.6147632306564689 0.961935437880314 0.3073297118149702 0.0181972414507802 0.0516364610584135 0.1018169846714528 0.0020064706347618 0.0013781701696679 +Overlap between signal transduction pathways contributing to lmna laminopathies 4 16 2.2044852155578907 0.0274902385688713 4.927184466019417 14.766990291262136 1.2077866030529698 0.2877996039599693 1.943257907759383 1.4611731122572065 0.935661776029738 0.2919054664837305 1.0 0.1952735388158895 0.0093807730237194 0.0230341265569123 0.020723717832043 +G1 to s cell cycle control 2 23 2.199052835101234 0.0278741656589063 6.900485436893204 24.733009708737864 0.2427705123410361 0.6554568890773506 4.5732760832124555 3.009947532023907 0.8058923051029326 0.3212929414660505 0.004094381550339 0.0315268496209905 0.1088269092294783 0.1655021226103433 0.5396622799916891 +Cholesterol biosynthesis with skeletal dysplasias 3 5 2.1897760147693264 0.028540485052122 2.703883495145631 6.024271844660194 1.6250539245333766 0.1427602110791373 1.3052115351448448 0.7101163612316155 0.9675759117714408 0.205892393525391 1.0 1.0 0.0018987369599165 0.0004573905935078 0.0001708540892308 +Male infertility 3 19 2.181756468075004 0.029127510937382 4.771844660194175 21.143203883495147 0.0444814370323583 0.5560383924350045 2.840652101933473 2.673381449757451 0.8805323935686871 0.3007001850197258 0.1135831106778655 0.0049299691055274 0.0327043685536917 0.096818905200251 0.4653980221544829 +Nrp1triggered signaling pathways in pancreatic cancer 1 10 2.179562601994179 0.0292898994997914 3.5242718446601944 10.155339805825244 -0.1581030855894588 0.5627629700317509 2.497939578871497 2.3013600096987736 0.8375438042065276 0.2894955313304667 0.0017757260688105 0.0142466262053111 0.0523352985295366 0.2345960405017343 0.5569491745948094 +Cell cycle 6 45 2.1716974477560376 0.0298784911757425 13.604368932038836 49.62135922330097 0.0249984674289128 0.7560897539313539 7.374930003933479 5.628665372951865 0.6307917639367615 0.2837424250752632 0.0146052019149518 0.0164824785433421 0.0046116462239443 0.0189568719932508 0.3013722093479412 +Wnt signaling pathway 1 11 2.136116072171825 0.0326699540415971 3.9563106796116503 12.050970873786408 -0.1668721405390101 0.6077108119526166 2.6112218582109348 2.3264673893512393 0.8231911322186768 0.2957072479206077 0.0709369996773478 0.0188245552589776 0.0678620701894922 0.2887846572413305 0.1636366172223574 +Progeriaassociated lipodystrophy 3 10 2.130913653136861 0.0330962563819632 2.5606796116504853 9.87135922330097 0.8348691672738174 0.3132697473637388 1.651332949166155 0.8732569863233294 1.0627007810416775 0.2700069969953336 1.0 1.0 0.012905013470629 0.0007869115437374 0.0097510399506001 +Integrated cancer pathway 2 12 2.057575856260911 0.0396308662750688 5.533980582524272 14.570388349514564 -0.1404285602316551 0.6609702247616228 3.450947622721706 2.757583866580215 0.6906701888261467 0.2846381743249511 0.0023755233326464 0.0188245552589776 0.0088166073526355 0.0901467992310857 0.1636366172223574 +Fatty acid betaoxidation 5 21 2.037186525263422 0.0416313536461372 5.162621359223301 19.570388349514563 0.1995607006787997 0.4670713659716193 3.5273220572363555 1.315478001889997 1.0772652457386651 0.2899601798313401 1.0 0.134742527043449 0.2540772386550496 0.0056128198685199 0.0027845492980534 +Eicosanoid metabolism via cyclooxygenases cox 3 6 2.0243100256869995 0.0429382627170276 2.1723300970873787 5.970873786407767 -0.5997976144138961 0.3148044959908401 1.0869532585081771 0.910630963157096 1.2684242485629602 0.2767828501620498 0.0198359893050149 0.0014481500629001 0.0057815105752346 0.000142755965642 0.0019884945269669 +Angiopoietinlike protein 8 regulatory pathway 4 27 2.011816260527047 0.0442393092146451 7.575242718446602 28.25242718446602 0.0554077707393526 0.6876386171429575 4.071171283635633 4.140654342084138 0.7247314269394591 0.2975639551036786 0.1643017062783413 0.0145949948181238 0.0857236814467353 0.1179506058012683 0.4191175542383009 +T cell receptor and costimulatory signaling 1 7 2.001725694354153 0.0453142413792608 2.004854368932039 4.997572815533981 0.0830042136398081 0.610725986843673 1.434652871703374 1.6480332297169549 0.8275331080085909 0.2993058931533784 0.0296145418928731 0.0032958763634803 0.012905013470629 0.0693365470158766 0.0539281835546241 +Small cell lung cancer 2 8 1.996233871162689 0.0459084722403162 3.895631067961165 12.45873786407767 -0.0228219556353496 0.6257817052219004 2.6349555254635137 3.2613872739529466 0.7561717293401203 0.2839951877209646 0.1254250484281346 0.3208381238265493 0.5432530093799623 0.5811837748974361 0.7527687502855307 +1q211 copy number variation syndrome 1 9 1.9858808343933227 0.047046557301742 1.866504854368932 8.890776699029127 0.7558686703595463 0.4317742326000632 1.7233813053885791 1.5024938423345304 0.794994669182033 0.2981691736709426 1.0 0.0875404472016038 0.1693528922958147 0.0762921742488627 0.2348875720984273 +Constitutive androstane receptor pathway 0 5 1.9633695275452376 0.0496032519392488 1.3470873786407769 5.580097087378641 0.3129409554034168 0.503782578475575 1.3789035541989327 0.7477422264229717 0.9528192116668128 0.3098481746082029 0.0279911849957302 0.0786913117950012 0.152955667850895 0.3411306657380243 0.5711774547855736 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c864839a3cda94134328a5fe1f7a50492899a097 --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 594, + "title": "Average number of proteins per term", + "value": 10.45959595959596 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..443c79b0ba204fa0346392fc853b52774e0e4140 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3384473088246cdc331035ff13bf4a04fae70562 --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,192 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Dna irdamage and cellular response via atr 0.6366160516219992 2.601731873322294 0.009275433873408 0.9960550493456376 0.3049875279139707 31 P53350,P06493,P24941,Q9UQ84 4 +Type i collagen synthesis in the context of osteogenesis imperfecta 0.7839824610686618 2.528437326435569 0.0114571539998256 0.9989350590767656 0.3049875279139707 12 O15460,Q32P28,P13674,O75718 4 +Mitochondrial long chain fatty acid betaoxidation 0.7190724468052405 2.4691319958066837 0.0135441248584624 0.9996965184773218 0.3049875279139707 14 Q9BY49,O43772,P23786,P33121,P42126 5 +Mirna regulation of dna damage response 0.658250885578629 2.464056604197262 0.0137374414758077 0.9997298701896192 0.3049875279139707 21 P06493,P24941,P41440 3 +Dna damage response 0.6639317553546165 2.43822976391747 0.0147593895116939 0.9998540752472868 0.3049875279139707 20 P06493,P24941,P41440 3 +Ketogenesis and ketolysis 0.8995982518868249 2.371778734461613 0.0177026884738962 0.999975321684184 0.3049875279139707 6 P53985,O43772,P35610 3 +Dna mismatch repair 0.6851226284439912 2.3634617888275993 0.0181050936270743 0.999980652973642 0.3049875279139707 16 Q9UQ84 1 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.6415972470112894 2.3627125052778983 0.0181417371177652 0.9999810771395672 0.3049875279139707 21 P35610,P37268,Q15392,Q16850,Q9BWD1,P33121,Q14739,Q9UBM7,Q15126 9 +Influence of laminopathies on wnt signaling 0.7734405324518905 2.361175000788707 0.0182171317341384 0.9999819208904052 0.3049875279139707 11 P49354,P49841,O60725,O75844,P50402 5 +Neural crest differentiation 0.8388582425312487 2.3584656688778716 0.0183506570904188 0.999983324078287 0.3049875279139707 8 Q9NR77 1 +Atm signaling pathway 0.7233639222179946 2.3557753451397274 0.0184840926008467 0.9999846176921428 0.3049875279139707 13 P06493 1 +Vitamin a and carotenoid metabolism 0.909343451479964 2.2484507334713686 0.0245474632407418 0.9999996123420996 0.3221888944977058 5 O94788 1 +Statin inhibition of cholesterol production 0.905150519779926 2.2321531233094305 0.0256048443937793 0.9999997964556872 0.3221888944977058 5 Q8WTV0,P35610 2 +Omega3 omega6 fatty acid synthesis 0.8619441741304205 2.220405128833508 0.0263912792148657 0.99999987400119 0.3221888944977058 6 P33121,Q15067,O15254 3 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.6564962561890287 2.2044852155578907 0.0274902385688713 0.9999999355804482 0.3221888944977058 16 P49841,O75844,P49354,O60725 4 +G1 to s cell cycle control 0.5955547246580173 2.199052835101234 0.0278741656589063 0.9999999490486244 0.3221888944977058 23 P06493,P24941 2 +Cholesterol biosynthesis with skeletal dysplasias 0.8942829438878205 2.1897760147693264 0.028540485052122 0.9999999660940782 0.3221888944977058 5 Q16850,Q15392,Q14739 3 +Male infertility 0.629799591073954 2.1817564680750037 0.029127510937382 0.999999976322066 0.3221888944977058 19 Q15165,P08183,P41440 3 +Nrp1triggered signaling pathways in pancreatic cancer 0.7590602966047773 2.179562601994179 0.0292898994997914 0.9999999785616248 0.3221888944977058 10 P49840 1 +Cell cycle 0.5410002914937552 2.1716974477560376 0.0298784911757425 0.9999999850471722 0.32268770469802 45 Q9Y619,Q9Y3B8,P49841,P53350,P06493,P24941 6 +Wnt signaling pathway 0.7261231635101053 2.136116072171825 0.0326699540415971 0.9999999973000332 0.3389513153601062 11 P49840 1 +Progeriaassociated lipodystrophy 0.7485374884293878 2.1309136531368615 0.0330962563819632 0.9999999979219998 0.3389513153601062 10 O75844,P49354,P09874 3 +Integrated cancer pathway 0.6882113833038094 2.057575856260911 0.0396308662750688 0.9999999999629928 0.3804766033000815 12 P06493,P24941 2 +Fatty acid betaoxidation 0.5892936456046799 2.037186525263422 0.0416313536461372 0.9999999999892758 0.3804766033000815 21 P35610,O43772,P23786,P33121,P42126 5 +Eicosanoid metabolism via cyclooxygenases cox 0.8141002300591721 2.0243100256869995 0.0429382627170276 0.999999999995232 0.3804766033000815 6 Q15067,Q8N8N7,O15254 3 +Angiopoietinlike protein 8 regulatory pathway 0.5559335797161389 2.011816260527047 0.0442393092146451 0.9999999999978748 0.3804766033000815 27 Q9UPT5,P49840,P49841,P41440 4 +T cell receptor and costimulatory signaling 0.7709503639537113 2.001725694354153 0.0453142413792608 0.9999999999989108 0.3804766033000815 7 P49840 1 +Small cell lung cancer 0.7555426756031008 1.996233871162689 0.0459084722403162 0.9999999999992476 0.3804766033000815 8 P24941,O00459 2 +1q211 copy number variation syndrome 0.7389801029107718 1.9858808343933227 0.047046557301742 0.9999999999996296 0.3804766033000815 9 Q9NPH0 1 +Metapathway biotransformation phase i and ii 0.5763002562256859 1.954654239672854 0.0506238946714496 0.9999999999999604 0.3860119855568271 21 P07099,Q16850 2 +Pregnane x receptor pathway 0.8322660768441131 1.944271847652974 0.0518626776664175 0.9999999999999818 0.3860119855568271 5 P08183 1 +Eicosanoid metabolism via lipooxygenases lox 0.7946057132547614 1.9432318934903483 0.0519881462029396 0.9999999999999832 0.3860119855568271 6 Q15067,Q8N8N7,O15254 3 +Proximal tubule transport 0.6823038102374248 1.9226474362222397 0.0545243423274302 0.9999999999999966 0.3998451770678214 11 P08183,O15439,P36543 3 +Allograft rejection 0.7215459156689275 1.9064353280432096 0.0565937488597014 0.9999999999999992 0.4099595953983252 9 P08183,P08670,Q9BY49 3 +Folate metabolism 0.6051330279643677 1.880146669632171 0.060088091494566 1.0 0.4207344904353968 15 P41440 1 +Familial partial lipodystrophy fpld 0.7425760470522532 1.877784475173436 0.0604106549074245 1.0 0.4207344904353968 7 O75844,P49354 2 +Sphingolipid metabolism in senescence 0.6070280876995523 1.8621160187940633 0.0625867385492795 1.0 0.4224604852076369 14 Q06136,P24941 2 +Vitamin d receptor pathway 0.6672008026666112 1.8479897302559407 0.0646038285078072 1.0 0.4311761138610953 11 Q92783,Q92604,P24941,P08183 4 +Microtubule cytoskeleton regulation 0.5725069670029418 1.834062229900971 0.0666447572243307 1.0 0.43535252402929 19 Q96GD4,Q13464,P49841,P17252,P25054,P06493 6 +Heme biosynthesis 0.7945303029802826 1.791974070342847 0.073137119659542 1.0 0.4544926738152278 5 P50336,P22830 2 +Regulation of apoptosis by parathyroid hormonerelated protein 0.8598085454760145 1.7467131511626257 0.0806871079950628 1.0 0.4736270414329788 4 P49840 1 +Tryptophan metabolism 0.5816535340326692 1.7460127780404666 0.0808087314834395 1.0 0.4736270414329788 15 Q15392,O94788 2 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.8478578716917382 1.7006447454552422 0.0890097165338037 1.0 0.4887204799608628 4 P07099 1 +Nrf2are regulation 0.702072423746916 1.698245968614275 0.0894613478053933 1.0 0.4887204799608628 7 P17252,P49841 2 +Ethanol effects on histone modifications 0.6570584828315942 1.6973088819689548 0.0896382789020351 1.0 0.4887204799608628 10 O94788 1 +Dna replication 0.5095133158670508 1.686988099240313 0.0916056403200604 1.0 0.4887204799608628 28 P24941,P41440 2 +Ppar signaling pathway 0.5582833043427363 1.6390002952910616 0.1012131981953143 1.0 0.5273740327019013 16 Q15067,O95864,P23786,P33121,O15254 5 +Mevalonate arm of cholesterol biosynthesis pathway 0.6603239384509846 1.62259304014363 0.1046764293020419 1.0 0.5376230808545144 9 Q9BWD1,P37268,P35610 3 +B cell receptor signaling pathway 0.5382325291340776 1.6208548018135605 0.1050487821943995 1.0 0.5376230808545144 19 P49840,P49841 2 +Acquired partial lipodystrophy barraquersimons syndrome 0.7370909433780536 1.5564785962589094 0.1195943284226381 1.0 0.5617280142523363 5 P49354,Q03252,O60725 3 +Notch signaling pathway 0.5911059907895251 1.5557989836494517 0.1197558999036738 1.0 0.5617280142523363 12 P49841,O00459 2 +Cholesterol biosynthesis pathway 0.6040737304789587 1.5305576854134382 0.1258787464059896 1.0 0.5776031537358854 11 Q16850,P37268,Q15126 3 +7oxoc and 7betahc pathways 0.633786034657771 1.4974839632090493 0.1342673753235874 1.0 0.5914736839346315 9 O15118,P34913,Q9UBM7 3 +Drug induction of bile acid pathway 0.9435562805872716 1.4927425399971663 0.1355045933515239 1.0 0.5914736839346315 2 P08183 1 +Sarscov2 and covid19 pathway 0.9597173814124702 1.4712869271296791 0.1412135372040803 1.0 0.5914736839346315 3 Q8WTV0 1 +Sphingolipid metabolism overview 0.6253341916696875 1.4574234763169045 0.1449995206183341 1.0 0.5914736839346315 9 Q06136,Q96G23 2 +Sphingolipid metabolism integrated pathway 0.6253341916696875 1.4574234763169045 0.1449995206183341 1.0 0.5914736839346315 9 Q06136,Q96G23 2 +Map3k1 role in promoting and blocking gonadal determination 0.7852328335177808 1.4571990145450584 0.1450614525575853 1.0 0.5914736839346315 4 P49841 1 +Nuclear receptors in lipid metabolism and toxicity 0.930831973898853 1.4423008687989298 0.1492175152106851 1.0 0.5914736839346315 2 P08183 1 +Regulation of wnt bcatenin signaling by small molecule compounds 0.709243193911504 1.4410336468017575 0.1495751773722937 1.0 0.5914736839346315 5 P49841 1 +Melatonin metabolism and effects 0.780391147400733 1.4382688440062843 0.1503577883402851 1.0 0.5914736839346315 4 P42892,P49841 2 +Pparalpha pathway 0.6400495356838001 1.41822193602859 0.1561259794882412 1.0 0.5944796911283031 7 P06493 1 +Gastric cancer network 1 0.598568413968823 1.4113809408956977 0.1581323196628625 1.0 0.5944974549350656 10 P49454,Q9ULW0,P84243 3 +Oxidation by cytochrome p450 0.6652556823855607 1.3904002953660366 0.1644073568376991 1.0 0.6142010689408383 6 Q6UW02,Q16850 2 +Striated muscle contraction pathway 0.6907250163292099 1.3639493104584677 0.1725835197532443 1.0 0.6289239922296144 5 O43707,P67936,P06753,P08670 4 +Cohesin complex cornelia de lange syndrome 0.5151126348343937 1.3586649275538971 0.1742527906675484 1.0 0.631000769413984 15 Q96GD4,P06493 2 +Atm signaling in development and disease 0.4760148971904429 1.3422391103070477 0.1795184791297033 1.0 0.631849219261951 22 Q96GD4,P06493 2 +Il5 signaling pathway 0.5080288268745854 1.316990025364094 0.1878419680563445 1.0 0.648710052473655 15 P49840,P49841 2 +Endothelin pathways 0.6020708474424723 1.294328204959385 0.1955520780392929 1.0 0.6606490598703771 8 P17252,P42892 2 +Vitamin b12 metabolism 0.6012624782504268 1.2905491064334809 0.1968600733957184 1.0 0.6606490598703771 8 Q8WTV0 1 +Sphingolipid pathway 0.5837574232163684 1.2592476396538184 0.2079408991232247 1.0 0.6825098290226763 9 Q06136 1 +Acute viral myocarditis 0.518255318580342 1.25652331325518 0.2089262988519986 1.0 0.6825098290226763 13 P49841 1 +Dna irdouble strand breaks and cellular response via atm 0.4737032302066424 1.2458453407014132 0.2128211801501029 1.0 0.6893049381115277 20 Q9UQ84 1 +Synaptic signaling pathways associated with autism spectrum disorder 0.5796912145545848 1.2397997380840813 0.2150494751347911 1.0 0.6893049381115277 9 P49841 1 +Eicosanoid synthesis 0.8792822185970558 1.2385840457469384 0.215499579476404 1.0 0.6893049381115277 2 Q9H7Z7 1 +Oxysterols derived from cholesterol 0.5873026407674231 1.2252401672351676 0.2204847445137883 1.0 0.6893049381115277 8 P34913,Q9UBM7 2 +Nucleotide metabolism 0.524930998369491 1.2038222202273037 0.2286582994346828 1.0 0.7001187106402145 12 P30520 1 +Glycogen synthesis and degradation 0.4760060054297909 1.1705179622134894 0.2417925899742163 1.0 0.7029436919584912 17 P49840 1 +Metabolism of spingolipids in er and golgi apparatus 0.7105308525742406 1.1646992318375105 0.2441407600448069 1.0 0.7029436919584912 4 Q06136 1 +Pi3kakt signaling pathway 0.4303235320030508 1.134825419639876 0.2564484733695338 1.0 0.7113778345676618 36 Q9UBI6,O00459,P49841,P23588,P24941 5 +Omega9 fatty acid synthesis 0.6310560194932662 1.115058795367644 0.2648252272079407 1.0 0.7212467395395451 5 P33121 1 +Tyrobp causal network in microglia 0.689413382127068 1.0823200613417117 0.2791103348235964 1.0 0.7303592021375165 4 Q15418,O15439 2 +Pathways affected in adenoid cystic carcinoma 0.4640680489833986 1.0581082641826214 0.2900060871726779 1.0 0.7489722425242205 15 P10412,P46100,Q969G3 3 +Physicochemical features and toxicityassociated pathways 0.4601114076923654 1.0525373841639805 0.2925530680723267 1.0 0.7522793179002687 16 P35080,P07197,P49841 3 +Insulin signaling 0.4126366598467795 1.0404430050747735 0.2981341305701632 1.0 0.7556804563793866 41 P49840,P49841,P41440 3 +Nanomaterial induced apoptosis 0.8358179764965994 1.0286114938624376 0.3036622746845023 1.0 0.7556804563793866 3 O95831 1 +Mevalonate pathway 0.6740032399577542 1.0224914431525998 0.3065483605238044 1.0 0.7556804563793866 4 Q9BWD1 1 +Initiation of transcription and translation elongation at the hiv1 ltr 0.5754210281171193 0.998914074937286 0.3178363173511767 1.0 0.7556804563793866 6 Q9H3P2 1 +Corticotropinreleasing hormone signaling pathway 0.4435902628018682 0.9949417824035852 0.3197645799474089 1.0 0.7556804563793866 18 P42892,P49841 2 +Measles virus infection 0.4343959573747309 0.9904644998622396 0.3219471326555594 1.0 0.7556804563793866 20 P24941,O00459 2 +Adipogenesis 0.454296669027574 0.9867725588393426 0.3237541501235863 1.0 0.7556804563793866 14 P14174 1 +Pi3kaktmtor signaling pathway and therapeutic opportunities 0.5679646011498609 0.9666481180746224 0.3337199713619263 1.0 0.7556804563793866 6 P49841 1 +Thermogenesis 0.410606762554017 0.9642139519215815 0.3349386709081678 1.0 0.7556804563793866 28 Q15418,O43772,P17252,P23786,P33121,O14497,Q969G3 7 +Transcriptional activation by nrf2 in response to phytochemicals 0.6580701471772554 0.96099385145061 0.336555259370199 1.0 0.7556804563793866 4 P09601,P17252 2 +Sterol regulatory elementbinding proteins srebp signaling 0.4095796445693625 0.9567258043785846 0.338705670106066 1.0 0.7556804563793866 28 Q8WTV0,Q16850,P49840 3 +22q112 copy number variation syndrome 0.4086005143977991 0.9487941934923584 0.3427252956540032 1.0 0.7556804563793866 31 P45973,Q9BW71,Q92973,Q9NQ50,O94788,P60953,P53350 7 +Wntbetacatenin signaling pathway in leukemia 0.5885686523574302 0.9391839650148668 0.3476363003100284 1.0 0.7556804563793866 5 P49841 1 +Arachidonate epoxygenase epoxide hydrolase 0.8019575856443588 0.9391044027036451 0.3476771440371997 1.0 0.7556804563793866 2 P34913 1 +Il7 signaling pathway 0.5251209283434366 0.9349508263485586 0.3498136417806663 1.0 0.7556804563793866 8 P49841 1 +Sleep regulation 0.6421424472259833 0.899996133769074 0.3681223081911429 1.0 0.7699459544561228 4 Q99808 1 +Effect of progerin on genes involved in hutchinsongilford progeria syndrome 0.4498811325352819 0.8784917241737289 0.3796769268899229 1.0 0.7777215805398218 13 P45973,O95983,P84243,Q13185,P83916,Q13330,Q12873,O60341 8 +Wnt signaling pathway and pluripotency 0.4284054822045713 0.8502748783972511 0.3951722800194153 1.0 0.8011342468652993 15 P17252,Q9H0H5,P49841 3 +Purine metabolism 0.5026452587321713 0.8314141822889877 0.4057396899315206 1.0 0.8087562946957156 8 P30520 1 +Wnt signaling 0.4233654948764563 0.8212942778542304 0.4114786662798029 1.0 0.8147277592340096 15 P17252,P49841,P25054 3 +Mrna protein and metabolite inducation pathway by cyclosporin a 0.7696574225122306 0.8184562576956175 0.4130967094375704 1.0 0.8152141043385941 2 Q15758 1 +Oxidative damage response 0.7623819159897955 0.7760364019266051 0.4377274928462984 1.0 0.8265260534193719 3 P60953 1 +Apoptosis modulation and signaling 0.4307730349334769 0.7750514288357465 0.4383092707526972 1.0 0.8265260534193719 13 O95831 1 +Methionine de novo and salvage pathway 0.4869528422914879 0.7600445836198114 0.4472279356992721 1.0 0.8273439914627916 8 Q13126 1 +Chromosomal and microsatellite instability in colorectal cancer 0.407334263922575 0.7556055859841039 0.4498857057954237 1.0 0.8273439914627916 17 P20585,P49841,P25054 3 +Lncrna in canonical wnt signaling and colorectal cancer 0.4237441822521151 0.7374864083166411 0.4608266056362304 1.0 0.839665655668469 13 P61978,P49841 2 +Proteasome degradation 0.372135270965148 0.7227718764281459 0.4698200483293151 1.0 0.8492358154600277 42 Q99436,P28070,P49721 3 +Dna repair pathways full network 0.3685847001089176 0.7142468119826665 0.4750745749908782 1.0 0.8492358154600277 44 P78549,P09874,Q9UQ84,P41440 4 +Embryonic stem cell pluripotency pathways 0.4308300537042659 0.7081898742349982 0.4788273534061253 1.0 0.8492358154600277 12 P49841 1 +Nucleotide excision repair in xeroderma pigmentosum 0.3751854862087808 0.7067207355969661 0.4797400409991414 1.0 0.8492358154600277 29 P41440 1 +Mecp2 and associated rett syndrome 0.3996639574525876 0.6975233161596011 0.4854753529275513 1.0 0.8492358154600277 16 Q9UQE7,Q00013,P31943,P52597,P35637,P67809 6 +Glioblastoma signaling pathways 0.3912831002214963 0.6947344291178041 0.4872217474384619 1.0 0.8492358154600277 19 P24941 1 +Joubert syndrome 0.3987701228793471 0.6924335653046698 0.4886650930723673 1.0 0.8492358154600277 16 Q10713,P09874,Q9Y4I1,P49959,O75695 5 +Cardiac hypertrophic response 0.4631650983938896 0.6897319261833974 0.4903627847276464 1.0 0.8492358154600277 9 P49841 1 +Il6 signaling pathway 0.4267006715084801 0.6872339807813531 0.4919352941110806 1.0 0.8492358154600277 12 P49841 1 +16p112 distal deletion syndrome 0.4704552615827105 0.6861296932127279 0.4926313279787662 1.0 0.8492358154600277 8 Q9H2V7 1 +Base excision repair 0.411608256555794 0.6734033518197196 0.5006907168048684 1.0 0.8562951311356339 13 P09874 1 +Leptin signaling pathway 0.3657937894652138 0.6522994761526072 0.514207997923029 1.0 0.8603931007500822 26 P49840,P49841 2 +Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway 0.7223491027732373 0.6497260604937851 0.5158691871418069 1.0 0.8607480257366102 2 P09601 1 +Endometrial cancer 0.4061816098943175 0.6451135336431506 0.518853614134754 1.0 0.8633026520897586 13 P49841 1 +Breast cancer pathway 0.3620730837743673 0.6384276193680142 0.5231953567069647 1.0 0.8634324283772793 24 P09874,P49841 2 +Thyroid stimulating hormone tsh signaling pathway 0.3787839522544995 0.619751959745916 0.5354211012401511 1.0 0.8672437790666291 19 P24941 1 +Signal transduction through il1r 0.7127183343500796 0.6151207323395212 0.5384749912932669 1.0 0.8678301402512278 3 Q9BQ95 1 +Orexin receptor pathway 0.3734899751653917 0.6066246113445191 0.5441000633452453 1.0 0.8678301402512278 20 P50336,O00459,P11166,Q8TDW0,P17252,Q9H4L5 6 +Amyotrophic lateral sclerosis als 0.4271400714815337 0.5773809552984797 0.563682136599104 1.0 0.8822286185061787 10 O96008,P07197,Q08209,P20339 4 +Tumor suppressor activity of smarcb1 0.3771149377584818 0.5638758469805389 0.5728386286740539 1.0 0.8842835565367437 15 O14497,Q969G3,Q96GM5,P84243 4 +Fluoropyrimidine activity 0.3902119672991387 0.5634231902385876 0.5731467496071487 1.0 0.8842835565367437 13 Q99808 1 +Prostaglandin synthesis and regulation 0.448251897967941 0.5578892491825711 0.576920013210078 1.0 0.8873773404673 7 P09525,O15439 2 +Preimplantation embryo 0.4466897302179233 0.5514167754321564 0.5813480035526961 1.0 0.8873773404673 7 Q99729 1 +Ranklrank signaling pathway 0.3963742947287575 0.5375219523881627 0.5909071254533933 1.0 0.8912657240453086 12 O00459,P07948,Q15750 3 +Alpha 6 beta 4 signaling pathway 0.4136437793843179 0.5169423873428326 0.605196377091989 1.0 0.8946316275280046 10 P07942,O00459 2 +Micrornas in cardiomyocyte hypertrophy 0.3606144035634362 0.4908448392458804 0.6235361934782886 1.0 0.9120918804218606 17 O00459,Q13464,P49841,Q15750 4 +Erbb signaling pathway 0.3584924687978088 0.4894062902535556 0.6245540836323018 1.0 0.9120918804218606 18 P49841 1 +Ebola virus infection in host 0.3443951357522932 0.4888444245358886 0.6249518439927564 1.0 0.9120918804218606 38 O00459,O15118,P51151,P20339,P41440 5 +Androgen receptor signaling pathway 0.3374910620267926 0.4639993498851524 0.6426482114097152 1.0 0.9287908456870336 26 O00459,Q13464,P49841,O75928,Q5VUA4,Q969G3 6 +Extracellular vesiclemediated signaling in recipient cells 0.5172002312540666 0.4555788333952428 0.6486928668322094 1.0 0.9352311005256588 4 Q9NWH9,P25054 2 +Tlr4 signaling and tolerance 0.6485717792814873 0.4266805592596682 0.6696120123456786 1.0 0.9352311005256588 3 Q15629 1 +Histone modifications 0.4089719597984271 0.4266353448877361 0.6696449496255366 1.0 0.9352311005256588 8 P84243,Q01105 2 +Retinoblastoma gene in cancer 0.3324614653187985 0.4188513591863366 0.6753247671772855 1.0 0.9352311005256588 42 P06493,P24941,Q9Y619 3 +Mirna regulation of p53 pathway in prostate cancer 0.64502446982055 0.4051836304260172 0.685342536679042 1.0 0.9352311005256588 2 O14681 1 +Mirnas involved in dna damage response 0.6450244698205477 0.4051836304260112 0.6853425366790464 1.0 0.9352311005256588 2 P16104 1 +Metastatic brain tumor 0.6450244698205407 0.4051836304259912 0.6853425366790611 1.0 0.9352311005256588 2 P60953 1 +Angiogenesis 0.6437194127243022 0.4014912578336245 0.6880584732489201 1.0 0.9352311005256588 2 P19174 1 +Erk pathway in huntingtons disease 0.6437194127243008 0.4014912578336206 0.688058473248923 1.0 0.9352311005256588 2 P42858 1 +Chemokine signaling pathway 0.3260020547242888 0.3983082887354183 0.6904029513483649 1.0 0.9352311005256588 25 Q9UBI6,P49841 2 +Nuclear receptors metapathway 0.3199842635324519 0.3929746004063375 0.6943382412993528 1.0 0.9352311005256588 50 Q15067,P08183,P23786,Q14914,P06493 5 +Epithelial to mesenchymal transition in colorectal cancer 0.3327647300843512 0.3730923062766917 0.7090797446556263 1.0 0.9423137480155188 20 P49841,O00459 2 +Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells 0.3861496004893461 0.3629120635573643 0.7166705748350948 1.0 0.9423137480155188 9 P28482,P61020,Q8WUM4,P31943,P51148,P20339,P62070 7 +Tgfbeta signaling pathway 0.3255945356516299 0.3624876931035248 0.7169876186005186 1.0 0.9423137480155188 32 O00459,Q13464,O75928,Q7Z3T8,Q15750,P06493 6 +Prolactin signaling pathway 0.3297627947198243 0.357109568806476 0.7210097812902463 1.0 0.943352835354826 20 P49841 1 +Purine metabolism and related disorders 0.3452936664994324 0.3507469605369163 0.7257781915103627 1.0 0.943352835354826 13 P30520 1 +Gpr40 pathway 0.6130505709624701 0.3197190808433209 0.7491812939940221 1.0 0.9665558094486334 2 P19174 1 +Egfr tyrosine kinase inhibitor resistance 0.3209434071866429 0.2961970115052094 0.7670796309735286 1.0 0.9665558094486334 18 P49841 1 +Ddx1 as a regulatory component of the drosha microprocessor 0.4508429834954791 0.2661683864000423 0.7901095290604188 1.0 0.9720346640544982 4 P49959 1 +Mitochondrial complex i assembly model oxphos system 0.3050853150933118 0.2626916801612775 0.7927882299120899 1.0 0.9720346640544982 27 Q8N183,P03915 2 +Dna damage response only atm dependent 0.3128369223865059 0.2586083766128946 0.7959374194658184 1.0 0.9720346640544982 18 P49841 1 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0.8274975486970828 1.0 0.9720346640544982 3 P35222 1 +Exerciseinduced circadian regulation 0.3037421304008702 0.2162177474828052 0.8288180202399327 1.0 0.9720346640544982 16 Q93062,Q13185,Q96PU8,Q00577,Q96KR1 5 +Tnfalpha signaling pathway 0.3014804244719704 0.2071835628951669 0.835866503723347 1.0 0.9729660691710412 16 P53350 1 +Mbdnf and probdnf regulation of gaba neurotransmission 0.3503734649934203 0.203574718261964 0.8386858513124742 1.0 0.9729660691710412 7 O00459 1 +Smc1smc3 role in dna damage cornelia de lange syndrome 0.3315701513367122 0.1516475047461777 0.8794649633029283 1.0 0.984969053556575 7 Q9UQE7,Q14676,Q92878,P49959,Q14683 5 +Genes related to primary cilium development based on crispr 0.3225019917523554 0.1508215398471689 0.8801164942890827 1.0 0.984969053556575 9 Q10713,O95684 2 +Hedgehog signaling pathway wp47 0.5164763458401136 0.1333328143784968 0.8939301771545607 1.0 0.9943717700932754 2 Q96ST3 1 +Hair follicle development organogenesis part 2 of 3 0.4853133159268981 0.1069774801809532 0.914806845427979 1.0 1.0 3 P05556,P35222 2 +Alzheimers disease 0.2643794600880638 0.0945169736441362 0.9246984997851472 1.0 1.0 80 P28074,O00459,P28070,P49841,P49721,Q99436 6 +Mrna processing 0.2823989727621545 0.0871839831020534 0.9305252705076028 1.0 1.0 98 P07910,P31943,Q15233,Q99729,P35637,Q96I25,Q9UHI6,O95400,Q08170,Q13243,O75400,O75533,Q9UKA9,P49755,P09012,Q16629,P23246,P84103,P22626,P33240,Q13242,P61978,O75494,P38159,Q8IWZ8,Q92879,P09651,P55795,P62995,P67809,Q07955 31 +Burn wound healing 0.2976534098211419 0.0812130374204806 0.935272531403856 1.0 1.0 8 P08670,P31949 2 +Alzheimers disease and mirna effects 0.2623272100272737 0.0613969073968222 0.9510431152550662 1.0 1.0 82 P28074,O00459,P28070,P49841,P49721,Q99436 6 +Robo4 and vegf signaling pathways crosstalk 0.4313213703099464 0.0580139215456896 0.9537375394140252 1.0 1.0 2 O94813 1 +Complement system 0.2690159837613205 0.052874087220804 0.9578322309096274 1.0 1.0 11 P07942 1 +Notch signaling 0.4128590078329029 0.0498760461899947 0.9602211659115492 1.0 1.0 3 P56545,Q92542 2 +Mitochondrial immune response to sarscov2 0.2711808963035668 0.0459151135690724 0.9633779079956823 1.0 1.0 10 Q9Y276,P35232,Q99623,Q9BQ95,Q7Z434,Q9Y6M9,Q9Y375,O94826,Q00653 9 +Myometrial relaxation and contraction pathways 0.2557998023663956 0.0458570165337777 0.9634242139481876 1.0 1.0 22 Q9Y3B8 1 +Serotonin and anxietyrelated events 0.337030995106037 0.0354681717820524 0.9717064256375052 1.0 1.0 2 Q08209 1 +Glial cell differentiation 0.2969004893964097 0.0336713512456582 0.9731392244072838 1.0 1.0 2 P09543 1 +Dopamine metabolism 0.3449420535195589 0.0292583505499545 0.9766585441155446 1.0 1.0 3 P17252 1 +Gdnfret signaling axis 0.3426892950391679 0.0289165070915914 0.9769311803716184 1.0 1.0 3 P35222,O94813 2 +Endoplasmic reticulum stress response in coronavirus infection 0.2533917664819635 0.0128154228590962 0.989775051843834 1.0 1.0 6 O14974,Q12972 2 +Homologous recombination 0.252916873069721 0.0124311730469264 0.9900816144085844 1.0 1.0 6 Q9Y2S7,P49959,Q92878 3 +Ccl18 signaling pathway 0.2485881850267688 0.0096051915950044 0.9923362837650076 1.0 1.0 10 P00403,P08670 2 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..fff567fcb85be9c3b28c08ba752110146a74f66b --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoe and mir146 in inflammation and atherosclerosis", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgf23 signaling in hypophosphatemic rickets and related disorders", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Galanin receptor pathway", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthesis ii from tryptophan", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP1", "AKAP12", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1A2", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANP32A", "ANXA1", "ANXA2", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APC", "APEX1", "APMAP", "APPL1", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARL5B", "ARL8B", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AURKB", "BAG3", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAS3", "BCAT2", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BLVRA", "BLVRB", "BPTF", "BRD1", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CASK", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CERS1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHMP6", "CHORDC1", "CHRAC1", "CHTF18", "CIP2A", "CKB", "CLASP1", "CLCN7", "CLIC1", "CLPTM1L", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COA3", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COQ8A", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CRK", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAG1", "DARS", "DAXX", "DBNL", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDAH2", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEGS1", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFNB1", "EFTUD2", "EHD1", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERBIN", "ERCC2", "ERCC3", "ERI1", "ESD", "ESS2", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC2", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAM120A", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FKBP10", "FKBP1A", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXO3", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAPDH", "GART", "GBA", "GCDH", "GCLM", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNG12", "GNG5", "GNPAT", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2E2", "GTF2I", "GTPBP2", "GTPBP4", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIRIP3", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "ILF2", "IMP3", "IMPAD1", "IMPDH2", "INF2", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LAMB1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LPGAT1", "LPP", "LRP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM2", "LSS", "LTA4H", "LYN", "LYRM7", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1B", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MFAP1", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MMADHC", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPG", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTOR", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO5A", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NARS2", "NAT10", "NBN", "NCAPG", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NF1", "NFATC2IP", "NFKB2", "NGEF", "NKRF", "NME1", "NME2", "NONO", "NOP2", "NPC1", "NR3C1", "NSDHL", "NSF", "NTHL1", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "ORC3", "ORC5", "OSBPL3", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELO", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKB", "PI4K2A", "PIAS2", "PIGT", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKN1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNKP", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "QPRT", "RAB10", "RAB13", "RAB14", "RAB21", "RAB2A", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RB1", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RBPMS", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RTCB", "RTF1", "RTN3", "RTN4", "RUVBL1", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARS", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC13", "SEC23A", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT2", "SHOC2", "SIN3A", "SIRT1", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SNAP23", "SNAP29", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORT1", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSNA1", "SSR4", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STRAP", "STRN", "STUB1", "STX3", "STX4", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE2", "TAB1", "TALDO1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCF20", "TCP1", "TDP2", "TECR", "TELO2", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMED10", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPM4", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT2A", "TRRAP", "TSG101", "TSPO", "TTC19", "TTC21B", "TTC26", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TXNDC5", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBR5", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UPF1", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS18", "VPS33A", "VPS4A", "WARS", "WDCP", "WDHD1", "WDR1", "WDR5", "WNK1", "XAB2", "XIAP", "XPC", "XPNPEP3", "XPO1", "XPO5", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACTN4", "ADSS", "AGPAT1", "AGPS", "AIFM1", "ALDH1A2", "ANXA4", "APC", "ARID1A", "ATP6V1E1", "ATRX", "AURKB", "BCS1L", "CBX1", "CBX3", "CBX5", "CD2BP2", "CDC42", "CDK1", "CDK2", "CELF1", "CENPF", "CERS2", "CHD3", "CNP", "COX2", "CPT2", "CRTAP", "CSTF2", "CTBP2", "CTNNB1", "CYP20A1", "CYP51A1", "DDX20", "DHCR24", "DHCR7", "DNAJC3", "ECE1", "ECI1", "ECSIT", "EI24", "EIF4B", "EMD", "EPHX1", "EPHX2", "EXO1", "EXOC7", "FADS2", "FDFT1", "FECH", "FGFR1OP", "FNTA", "FUS", "GNG12", "GNPAT", "GSK3A", "GSK3B", "H2AFX", "H3-3A*", "HIRIP3", "HIST1H1E", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HTT", "ICMT", "ITGB1", "KDM1A", "KDSR", "LAMB1", "LBR", "LMNB2", "LPGAT1", "LRRC8C", "LYN", "MAPK1", "MAVS", "MBD3", "MDC1", "MIF", "MPP1", "MRE11", "MRPL40", "MSH3", "MTA1", "MTAP", "MYEF2", "MYO5A", "NCSTN", "ND5", "NDUFAF1", "NDUFAF2", "NDUFB9", "NEFM", "NELFA", "NFKB2", "NONO", "NPC1", "NTHL1", "OSBPL3", "P3H1", "P4HA1", "P4HA2", "PARP1", "PDCD6IP", "PECR", "PFN2", "PHB", "PHB2", "PIAS2", "PIK3R2", "PLCG1", "PLK1", "PMPCA", "PMVK", "POLDIP2", "PON2", "PPOX", "PPP1R12A", "PPP1R8", "PPP3CA", "PRKCA", "PRPF40A", "PSMB2", "PSMB4", "PSMB5", "PSMB7", "PTBP2", "PTGES2", "PTGR1", "PTGR2", "PURA", "PXMP2", "QKI", "RAB5A", "RAB5B", "RAB5C", "RAB9A", "RACGAP1", "RAD50", "RBM17", "RBMX", "RBPMS", "REXO2", "ROCK1", "RP2", "RPS6KA1", "RRAS2", "S100A11", "SCARB1", "SET", "SF3B1", "SFPQ", "SIN3A", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A15", "SLC25A20", "SLC29A1", "SLC2A1", "SLIT2", "SLTM", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SNRPA", "SOAT1", "SPNS1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "STAM", "SUGP1", "TAB1", "TMED10", "TNPO1", "TOMM40", "TOMM70", "TPM3", "TPM4", "TPX2", "TRA2B", "TRAM1", "VIM", "YBX1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF318"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/opencell_localization/basic/idx2term.json b/opencell_localization/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..3d53fbb772400c4ffcbfaa581ddfd3acc39c05ba --- /dev/null +++ b/opencell_localization/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "nuclear_punctae", "1": "centrosome", "2": "cytoskeleton", "3": "chromatin", "4": "golgi"} \ No newline at end of file diff --git a/opencell_localization/basic/plot_0.png b/opencell_localization/basic/plot_0.png new file mode 100644 index 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b/opencell_localization/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..6785abc7327d2c020d7960aeba6cc4801c3d75de --- /dev/null +++ b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:07a41b79d1508f2eeb72e2044514590a2a3fc0c92801aee05cd6a8e59cbc263f +size 67554 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..520fc3e01192bfd5b642b77c2ee7b51f6a6cbe71 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 91.58823529411765 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a5da490f82903750295822eb6978ca3e5171fb49 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2e4e266f1b9350224c90af95b4638517f9c08e83 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,7 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +nuclear_punctae 0.3355100973912978 0.9057039202769592 0.3650925869749883 0.999557333391794 1.0 72 P38159,Q15233,P98179,Q96PK6,P25440,P53350,P24941,P50995,Q5BKZ1 9 +centrosome 0.3322202491067257 0.4050904133083313 0.6854110530024491 0.999999997105065 1.0 32 Q9NSK0,Q10713,P17252,P53350,P06493 5 +cytoskeleton 0.3238202994566411 0.3458069642144442 0.7294877910106117 0.9999999997775784 1.0 35 O00139,P08670,P60953,Q96DE5,P06493 5 +chromatin 0.2838031533008703 0.1590605163636144 0.873621195494583 0.9999999999999994 1.0 91 Q96GD4,O15164,Q14004,Q9BWF3,P07910,P07305,P38159,Q8WVM7,Q15233,Q9NTZ6,O14497,P21127,Q96T37,Q9BQ61,P98175,Q969G3 16 +focal_adhesions 0.3478118876551245 0.136603760881426 0.8913440036191864 1.0 1.0 5 Q16512,Q13177,Q6RW13,P18206 4 +golgi 0.2497579346916719 0.0453958176814089 0.9637918145595412 1.0 1.0 63 P36543,Q8TAD4,Q8N6H7,Q9Y3E0,Q8IXU6,Q5VW38,O14976,P49755 8 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e8a8a0dcdf4da800c5ad458a31e93d01d318399f --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AAMP", "AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AGAP3", "AGTRAP", "AHCY", "AHSA1", "AKAP12", "AKAP8L", "AKR1A1", "AKT1S1", "ALCAM", "ALDH9A1", "ANAPC16", "ANAPC2", "ANAPC4", "ANXA11", "AP2B1", "AP2S1", "APC", "APPL1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8B", "ARPC2", "ARPC3", "ATG3", "ATG7", "ATG9A", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "AURKB", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BRD2", "BRD4", "BTF3", "BUB1B", "BYSL", "C1orf123", "C8orf33", "CAD", "CALD1", "CALM3", "CAMK1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDS2", "CETN2", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLCN7", "CLINT1", "CLNS1A", "CLPTM1", "CLTA", "CLTB", "CLTC", "CNN2", "COIL", "COPA", "COPB2", "COPE", "COPG1", "COPG2", "COPZ1", "CORO1B", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP2", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DAD1", "DBNL", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DEGS1", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DOCK7", "DRG1", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EBNA1BP2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1G", "EFTUD2", "EIF2AK2", "EIF2S3", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMG1", "ENO1", "EPN1", "EPS15", "ESD", "ESYT1", "EWSR1", "EZR", "FAM120A", "FAM50A", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GNL2", "GNL3", "GOLGA2", "GOLT1B", "GORASP2", "GOSR1", "GPR107", "GRB2", "GSK3A", "GSK3B", "GSPT1", "GTPBP4", "GYS1", "H1F0", "HDAC2", "HEATR3", "HGS", "HIP1", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HMGN2", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPBP1", "HSPH1", "IDI1", "IGF2BP1", "IGF2BP3", "ILF3", "IMP3", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "KDSR", "KIAA0319L", "KIAA0368", "KIF11", "KIF22", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LAMP1", "LAMP2", "LARP7", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LMAN1", "LMNA", "LMNB1", "LPCAT1", "LSM14B", "LSS", "LTV1", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MBOAT7", "MCM10", "MDH1", "MECP2", "MED14", "MED24", "MFN1", "MFN2", "MIF", "MKI67", "MPHOSPH10", "MRTO4", "MSH6", "MSN", "MTMR2", "MTOR", "MYBBP1A", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NANS", "NAPA", "NAPG", "NCAPH", "NCKAP1", "NCL", "NCLN", "NEK9", "NEMF", "NFKB2", "NHP2", "NIFK", "NOL10", "NOL11", "NOM1", "NONO", "NOP2", "NOP58", "NPM1", "NRBP1", "NSA2", "NSDHL", "NUCKS1", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP214", "NUP35", 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57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 0.0008905065788121 1.877054437832283e-05 1.8456219404983973e-06 2.5208008683948227e-05 0.000160196255065 +transmembrane signal receptor 2 7 2.5427758725970997 0.0109975747172623 3.266990291262136 7.169902912621359 1.6693846681257831 0.1085289610325799 1.5770125590990791 1.7927217985188668 1.0928815816574815 0.16461969248918 1.0 0.0097083087369112 0.0600500471997379 0.3859684085300801 0.6593661810718379 +non-receptor serine/threonine protein kinase 8 47 2.487327350220026 0.0128706908526308 16.135922330097088 52.12621359223301 -0.134221300875087 0.6060262879741318 7.554075018956698 12.250365250469567 0.92962806947858 0.321800658077224 0.0064722342721356 0.0052052890396093 0.0078111794266681 0.117607229695818 0.5938036324931917 +calcium-binding protein 3 6 2.449812039910771 0.0142930804496084 2.9150485436893203 5.973300970873787 -0.4136067607963649 0.4738157943355645 1.5842264804417423 0.6731795131978904 0.993496353582113 0.3160797205817164 1.0 1.0 0.0930016660897952 6.292953854873037e-05 0.0009118158302113 +serine protease 4 16 2.2456553420009087 0.0247260927223345 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 1.0 0.0230489069918226 0.0818055658939264 0.006410021202963 0.0302802497568866 +ATP-binding cassette (ABC) transporter 2 6 2.2115063660936296 0.0270007915217753 2.686893203883495 7.684466019417476 0.6951371488068213 0.3450534093319853 1.8332217537175712 2.163791049328932 1.0940500371142112 0.2754733493972692 0.0376931223304609 0.1049896535105009 0.2012104780589677 0.0173886328284286 0.0981468657129251 +protein modifying enzyme 5 21 2.1700358729607343 0.0300041284713401 6.487864077669903 24.82281553398058 0.9737051724681342 0.3238157719208961 2.575528657386725 2.871041189126622 1.1448244681235864 0.2930923238696635 0.004094381550339 0.0315268496209905 0.0186371594327644 0.0026843919056765 0.0215069931551279 +secondary carrier transporter 1 17 2.104750838305141 0.0353130025985557 6.104368932038835 14.6626213592233 1.264699085385324 0.2718921136589474 3.483843477892234 2.781747184831951 1.2916784116683784 0.322278600042778 0.1120923026939533 0.290515894493261 0.1512044234932328 0.516414990920093 0.6769796331686941 +protein-binding activity modulator 0 5 2.089716801284169 0.0366432468448214 1.529126213592233 4.25 0.2668550947983373 0.5086627191257674 1.193276558571054 0.9441310794299864 0.9807813955882424 0.3127844875765326 1.0 1.0 0.1854358412925483 0.4028006685093745 0.6487121027608701 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e1f8d0c445efe8ab50ab2b3441811cd18024ac6b --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 160, + "title": "Average number of proteins per term", + "value": 13.1875 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2efba05328e0fd28f0688b99b66dfc9ae9ebb584 --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6ce922986223d4f220b2505e5b7053ff047f0a6e --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,50 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +acyltransferase 0.7508027534334971 2.8764555601666726 0.004021688205821 0.4752154652688996 0.2540992079930386 19 Q8NCC3,P49354,P35610,Q9BWD1 4 +transporter 0.5231134125625088 2.68992891925274 0.0071467239740647 0.6825965056999155 0.2540992079930386 61 Q99595,Q9Y619,Q9NR77,Q567V2,Q9H2V7,O43772,Q99808,Q6N075,P41440,P53985,O60830 11 +transmembrane signal receptor 0.8994892113446555 2.5427758725970993 0.0109975747172623 0.8295578296760517 0.2540992079930386 7 Q99720,Q8WUJ1 2 +non-receptor serine/threonine protein kinase 0.5727915146687913 2.487327350220026 0.0128706908526308 0.874151657965135 0.2540992079930386 47 Q96GD4,O14874,Q14004,P49840,P49841,P53350,P06493,P24941 8 +calcium-binding protein 0.9192687687169844 2.449812039910771 0.0142930804496084 0.9000808244186855 0.2540992079930386 6 P20073,P09525,P50995 3 +serine protease 0.6638621923630119 2.2456553420009087 0.0247260927223345 0.9817922272787069 0.3596522577794109 16 P42785,Q9HB40,Q16740,Q4J6C6 4 +ATP-binding cassette (ABC) transporter 0.8597507106721607 2.2115063660936296 0.0270007915217753 0.987468648379946 0.3600105536236716 6 P08183,O15439 2 +protein modifying enzyme 0.6104285584513416 2.1700358729607343 0.0300041284713401 0.9923584451641662 0.3686629753423009 21 Q92791,O75718,O60725,O15460,Q9UMR5 5 +secondary carrier transporter 0.6319806624698481 2.1047508383051414 0.0353130025985557 0.9968243839854452 0.3686629753423009 17 Q6NT16 1 +lyase 0.6882073679872008 1.9516824954660936 0.0509759120979669 0.9997686030042796 0.4319549101280154 11 Q9UHG3,Q9BU89 2 +metalloprotease 0.5447086748474343 1.9333447236791024 0.0531937457965168 0.9998408601716527 0.4319549101280154 27 Q5JRX3,P55786,Q10713,P22695,Q7Z2K6,O75844,P42892 7 +primary active transporter 0.5523425020340682 1.8008381122234078 0.0717283998285502 0.9999932700754598 0.5063202453742958 21 O60888,Q9NS69 2 +esterase 0.7203486965003043 1.6286406096062542 0.1033891221346139 0.9999999738999968 0.5063202453742958 6 Q969T7 1 +histone 0.6152163645729052 1.493304722984306 0.1353574398487889 0.9999999999216828 0.5549027151652082 10 P10412,P07305,P16402,P16403,P84243 5 +oxidoreductase 0.4605683839974832 1.4846829789755664 0.1376278226639398 0.9999999999485768 0.5549027151652082 44 P03915,O95831,Q8N4Q0,O43396,O43676,O15254 6 +nucleotide kinase 0.5370063406511543 1.360571267544869 0.1736492167358776 0.9999999999999444 0.611795599376758 13 Q13126 1 +hydrolase 0.4568045622960344 1.3043819470638691 0.1921033873337272 0.9999999999999984 0.6282932516715208 25 Q96AB3,P07099,P34913,Q9BQG2,Q9BW91 5 +mitochondrial carrier protein 0.637819002163458 1.2708109700304215 0.2037959051387896 1.0 0.6521468964441268 6 Q70HW3 1 +calmodulin-related 0.5241858643140223 1.1998403974651712 0.2302013315525342 1.0 0.6696766008800995 12 Q14257,Q02818,P80303,O43852 4 +reductase 0.4162938402929105 1.0081108602488644 0.3134012445260261 1.0 0.7956057782231667 32 Q06136,Q9BY49,Q15392,Q14914,Q14739,Q8N8N7,Q9UBM7,Q9H7Z7 8 +ATP synthase 0.4305217040810376 0.9654358578848686 0.3343265484986002 1.0 0.7956057782231667 20 Q9Y5K8,P00846,P06576 3 +zinc finger transcription factor 0.5398552269902005 0.9601859516074708 0.3369616359475453 1.0 0.7956057782231667 7 Q9H1B7,Q9UBW7 2 +oxygenase 0.5313257924812151 0.9214958893186264 0.3567915864013091 1.0 0.7956057782231667 7 Q6UW02,Q16850,P30519 3 +DNA glycosylase 0.7947797716149979 0.9119918612329228 0.3617730019535523 1.0 0.7956057782231667 2 P78549 1 +actin binding motor protein 0.5266363447327891 0.9002867463648748 0.3679676724282146 1.0 0.7956057782231667 7 P06753,Q9Y4I1,O00159 3 +RNA splicing factor 0.340815800770324 0.8630002318380716 0.3881373394805256 1.0 0.8127827208956335 80 Q93062,P31943,P31942,Q96PK6,Q12972,O95400,Q13243,Q9H9Y2,Q12849,Q9P2K5,Q9HCS7,P09012,Q16629,P84103,Q9NTZ6,P62312,Q13242,Q9BWF3,Q9BZJ0,O75525,O75494,Q6IQ49,Q8IWZ8,P52597,O75934,P55795,Q14331,Q07955 28 +nucleic acid metabolism protein 0.6285381318236406 0.8483706613812665 0.3962315764366213 1.0 0.8127827208956335 4 Q9NYF8,Q9Y2W1 2 +major histocompatibility complex protein 0.6236622051577848 0.8299916212075782 0.406543520949377 1.0 0.8233792829354472 4 P04439 1 +SNARE protein 0.4498066154178026 0.8058118213287111 0.4203513608400433 1.0 0.8311703814858276 12 O95249,P56962,O15400,Q86Y82 4 +RNA helicase 0.4427658876742943 0.7081245230337075 0.478867932019376 1.0 0.8468708136543552 11 Q7Z478,Q8IX18,Q8IY37 3 +protease 0.3714720520736617 0.6951668924578792 0.4869507178512542 1.0 0.8468708136543552 39 Q99436,P28070,P49721 3 +extracellular matrix protein 0.5750608318284727 0.6515139996377163 0.5147147429613323 1.0 0.8668879881454018 4 P55081 1 +RNA processing factor 0.2971892630429136 0.2329095450856713 0.8158316463496433 1.0 1.0 25 Q13868,Q8N684,Q6P087,O95104 4 +heterotrimeric G-protein 0.3511449149521862 0.2208512409122144 0.8252082640345517 1.0 1.0 8 Q9UBI6,Q8NHH9,Q14344,P63218 4 +cell adhesion molecule 0.543929019697759 0.1906152759545182 0.8488270211554463 1.0 1.0 3 Q08722 1 +methyltransferase 0.3262056672064967 0.1822351749740228 0.8553981695125921 1.0 1.0 10 Q9BV86,P34897,Q8N6R0 3 +dehydrogenase 0.2591252510057892 0.1701899520089563 0.8648607535791839 1.0 1.0 67 P30837,O94788 2 +kinase inhibitor 0.5216118358774793 0.1544864674790023 0.8772261805174744 1.0 1.0 3 Q9NQG5 1 +GTPase-activating protein 0.2872876871244535 0.1538196668193515 0.8777519265064302 1.0 1.0 16 Q8N6H7,Q9H0H5,Q07960 3 +kinase 0.2859974720556679 0.1492629930643187 0.8813461153547253 1.0 1.0 16 Q9HA64,Q15126,Q8WVC6 3 +acetyltransferase 0.3049863026453475 0.12167287034589 0.903158099897546 1.0 1.0 10 Q5VZE5 1 +DNA-binding transcription factor 0.2747651275279351 0.1069080619532183 0.9148619173359808 1.0 1.0 19 P17480,Q00577,Q96JN0,Q8WXI9,Q9NXV6,P46100 6 +microtubule binding motor protein 0.2663852081880657 0.0827937964339423 0.9340155019217152 1.0 1.0 17 Q9NSK0,O00139,O95239,Q13561,O75935 5 +C2H2 zinc finger transcription factor 0.4487597911227154 0.0724632216196679 0.9422332733906452 1.0 1.0 3 Q9Y2X9,O95785 2 +kinase activator 0.427079934747138 0.0559933174095461 0.9553471307456228 1.0 1.0 2 P14635 1 +kinase modulator 0.2798716715784788 0.0435227557242928 0.9652848252656032 1.0 1.0 7 Q93052,O00459 2 +DNA helicase 0.2547416612164797 0.0122828830492455 0.990199923675118 1.0 1.0 9 P51532,P18074,P46063,O60264,P19447,P28370,P13010,P12956 8 +nucleotide phosphatase 0.2414243711205515 0.0040427003680251 0.9967744005786274 1.0 1.0 6 Q9H857,Q9BX68,P49902,Q5TFE4,Q86UY8 5 +histone modifying enzyme 0.234034132391189 0.0032494868273072 0.99740728919277 1.0 1.0 12 Q9H0E3 1 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8ca8e270be8b8f633db56dc40baf146b82e88af8 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "Rel homology transcription factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "antimicrobial response protein", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "hydroxylase", "immunoglobulin superfamily cell adhesion molecule", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "membrane-bound signaling molecule", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase inhibitor", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AGPAT5", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "ANAPC1", "ANAPC7", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APPL1", "APRT", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL5B", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATAD5", "ATG3", "ATG7", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BAG6", "BAIAP2", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDHA", "BCKDK", "BCLAF1", "BCR", "BDH2", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPHL", "BPNT1", "BRD1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKN2AIP", "CDS2", "CEBPZ", "CENPB", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHERP", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT7", "CNP", "COA3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAM3C", "FAM89A", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDE1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS2", "GLA", "GLB1", "GLCE", "GLDC", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOPC", "GOSR1", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GUF1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "ISOC1", "ISOC2", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LENG8", "LETM1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LYAR", "LYPLA1", "LYPLAL1", "LYRM7", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MAT2B", "MBLAC2", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIF4GD", "MIPEP", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MORF4L2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTF2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCDN", "NCOA5", "ND5", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NENF", "NF1", "NFKB2", "NGEF", "NHP2", "NIP7", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PHKB", "PI4K2A", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSMF1", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIOK2", "RIPK1", "RNASEH2A", "RNF2", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTN4IP1", "S100A11", "S100A13", "SACM1L", "SAE1", "SAMHD1", "SAP130", "SAP18", "SAP30", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMN1*", "SMNDC1", "SMPD4", "SNAP23", "SNAP29", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", 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0000000000000000000000000000000000000000..4ef2ea3e57817eac30979c8bdd213ad76d4dbbee --- /dev/null +++ b/pharos_dto/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e7d4331c2e6ad1612adeebf1b817eafa3fc847a72d96cf666e0c8e8df984f0ed +size 141745 diff --git a/pharos_dto/consensus.joblib b/pharos_dto/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..a1da06fcc31da8780369aa9680c7c1b00db47afe --- /dev/null +++ b/pharos_dto/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7b6b91d54e481992cc9b83f856be966c66b080f9ee0dc82605289a5604ab49d2 +size 303380 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..14a34f68411267dcb6bb31c2acbf1e21918b7fda --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,11 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +SLC superfamily of solute carriers 12 47 3.3718389517497904 0.0007466809660954 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 0.0361501341984463 0.0111376955132978 1.0115068547532244e-05 0.0004762934947769 0.0155853325236128 +CMGC group 5 14 3.156393127642437 0.0015973341136759 6.247572815533981 15.779126213592232 -0.153268389949456 0.5765849550881931 3.46926434271725 2.584917270387921 0.8944539059731658 0.3077759775494332 8.09008738184145e-05 4.56083100807583e-06 0.0001411644236219 0.0015231541907095 0.0390821401419673 +mRNA processing factor 34 75 2.8585071585637336 0.0042563950486989 25.347087378640776 75.25485436893204 -0.2985441958276097 0.5602779604890878 10.316515944124484 3.6776154061944775 1.2913421409729118 0.3651678095317845 1.0 1.0 0.0189557671296911 0.0002224125210767 2.3916700034174837e-08 +mRNA splicing factor 31 60 2.7976158601680816 0.0051481299712448 20.18446601941747 60.25 -0.0534479997211008 0.543839505368344 8.174667919166573 3.2318387263906065 1.3503022593676848 0.3639653466937346 1.0 1.0 0.0453414776018772 0.0001558609137303 5.355574478492799e-08 +CDK family 3 6 2.462981295679952 0.0137787103669673 2.9733009708737863 6.779126213592233 0.1942284521715007 0.5657664118918665 1.8425303877561647 1.511204500497056 0.8783804710728754 0.3084054520210429 0.0004400527817872 9.575570058867652e-05 0.0007685743700876 0.0009779431698101 0.0118865434534573 +Protein kinase 14 60 2.371835677613622 0.0176999605867411 20.09223300970874 68.12135922330097 -0.1885407530168121 0.6382294404073665 8.905449289760881 14.39153709303092 0.8281308874650661 0.3147542738878373 0.0190693919317974 0.025670635271445 0.0536080250949328 0.4758901411684216 0.7286927740005684 +SLC25 family of mitochondrial transporters 3 18 2.220733469915308 0.0263690190754259 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 0.1635258499471353 0.0498890213657128 0.0118572988629309 0.0319540971359957 +ATP-binding cassette transporter family 2 6 2.2115063660936296 0.0270007915217753 2.2135922330097086 6.097087378640777 0.6703089129361733 0.3321717891455754 1.6917876191440782 1.952168637803411 1.1544628029909134 0.2803059295197611 0.0312353468433775 0.0875404472016038 0.1693528922958147 0.0102137155300364 0.0618109910728358 +Signaling 3 18 2.1815078612978778 0.0291458736412879 5.66747572815534 18.009708737864077 1.330299096012152 0.2668377480945127 2.507969905227609 1.6994867622232877 1.0107551340834326 0.2926688105318188 1.0 0.3467229085425889 0.5778229381468787 0.3595041155184194 0.6245730475338752 +Receptor 6 27 2.138477509941032 0.032478007553258 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 0.1628913150338835 0.0142331659478869 0.0838856775027136 0.0436986166677031 0.2554949002325081 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d63a62ec1c1a2f038eeb6bdbc7da36dd0f05537d --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 1988, + "title": "Average number of proteins per term", + "value": 3.106639839034205 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..49044580d985be9dc3682cbf77d8030da2ea67c5 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..559d57e4d47a99cbbce0394c3ee0eb8862905cbf --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,69 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SLC superfamily of solute carriers 0.6881415198421199 3.3718389517497904 0.0007466809660954 0.7734877437151229 0.1034058788738251 47 Q6NT16,Q9BQT8,Q9H2V7,Q70HW3,O43772,Q8TAD4,Q99808,Q6N075,Q8IXU6,P30825,P41440,P53985 12 +CMGC group 0.8556980338875717 3.1563931276424375 0.0015973341136759 0.9583327191217352 0.1034058788738251 14 Q14004,P49840,P49841,P06493,P24941 5 +mRNA processing factor 0.51744020566589 2.8585071585637336 0.0042563950486989 0.999792374133763 0.1034058788738251 75 Q93062,Q01844,Q15233,P98179,Q96PK6,P35637,Q96SI9,Q13243,Q13595,Q9HCS7,P09012,Q16629,P19338,P23246,P84103,Q96PU8,Q92804,Q8IY67,Q96E39,P62312,Q13242,O95104,Q8WXF1,Q14011,Q9BWF3,O75525,Q9BZJ0,O75494,P38159,Q8IWZ8,O75934,P62995,Q96KR1,Q07955 34 +mRNA splicing factor 0.5409371812178247 2.7976158601680816 0.0051481299712448 0.9999650264106662 0.1034058788738251 60 Q93062,Q01844,Q15233,P98179,Q96PK6,P35637,Q13243,Q13595,Q9HCS7,P09012,Q16629,P19338,P23246,P84103,Q96PU8,Q92804,Q8IY67,Q96E39,P62312,Q14011,Q13242,Q8WXF1,Q9BWF3,O75525,Q9BZJ0,O75494,P38159,Q8IWZ8,O75934,P62995,Q07955 31 +CDK family 0.922606363676838 2.462981295679952 0.0137787103669673 0.9999999999989504 0.1049183235047606 6 P06493,P24941,Q14004 3 +Protein kinase 0.4960062163155892 2.371835677613622 0.0176999605867411 0.9999999999999996 0.1118569219802134 60 Q96GD4,P07948,O14874,Q14004,O14936,P49840,Q13464,P49841,P17252,O14976,P53350,P06493,P24941,P21127 14 +SLC25 family of mitochondrial transporters 0.6445137598457215 2.2207334699153076 0.0263690190754259 1.0 0.1269288375834064 18 Q9BQT8,Q70HW3,O43772 3 +ATP-binding cassette transporter family 0.8597507106721607 2.2115063660936296 0.0270007915217753 1.0 0.1273651459175799 6 P08183,O15439 2 +Signaling 0.6377858111779189 2.1815078612978778 0.0291458736412879 1.0 0.1300869053623845 18 Q8WUJ1,Q7Z4V5,P98172 3 +Receptor 0.5742243511366217 2.1384775099410316 0.032478007553258 1.0 0.1373750617359084 27 Q9NR77,Q567V2,O75381,A6NIH7,Q8WTV0,P39210 6 +Mitochondrial amino acid transporter subfamily 0.8843385389687687 1.8407946654930183 0.0656516548620818 1.0 0.1947992386056994 4 O43772 1 +Extracellular structure 0.6900130138938089 1.7611432699020655 0.0782141569844272 1.0 0.215061886701302 9 Q32P28,Q92791,O75718 3 +Dehydrogenase 0.4383495468234166 1.709098244674188 0.0874327526886467 1.0 0.2293091191886934 58 P03915,O94788,O95831,P30837,Q14914,Q8N8N7,Q8N4Q0 7 +CDK1 subfamily 0.9918433931484502 1.6840410414695584 0.0921737373411499 1.0 0.2352264311093788 2 P06493 1 +GSK family 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.2435471496707048 2 P49840 1 +GSK subfamily 0.9853181076672096 1.658226045888588 0.097271849516368 1.0 0.2435471496707048 2 P49840 1 +Kinase 0.4093009646555494 1.457158318319034 0.145072683348286 1.0 0.3042241503126505 94 Q9HA64,Q96GD4,O14874,Q14004,P49840,P49841,P11908,P55263,P06493,P24941,P53350 11 +Histone 0.573991306982376 1.376802720558337 0.168573249506122 1.0 0.3337884661535564 11 P10412,P16104,P07305,P16402,P16403,Q13330 6 +Bromodomain 0.6510949465717549 1.3287243955946326 0.1839389133198983 1.0 0.3539889251500076 6 O60885,P25440,Q6PL18 3 +F-type and V-type ATPases 0.4935133340920256 1.252849893312957 0.2102603400452385 1.0 0.38739355499368 16 Q9Y5K8,P00846,P06576 3 +Intracellular calcium-sensing protein 0.4853918300655193 1.1662830196848673 0.2435000362085895 1.0 0.4251418651919126 14 Q14257,Q02818,P80303,O43852 4 +Calmodulin 0.4853918300655193 1.1662830196848673 0.2435000362085895 1.0 0.4251418651919126 14 Q14257,Q02818,P80303,O43852 4 +Metalloprotease 0.4268483378430066 1.1238602095270331 0.2610723339263265 1.0 0.4424653025111144 38 Q5JRX3,P55786,Q10713,P22695,Q7Z2K6,O75844,P42892 7 +Serine protease 0.4320924547427012 1.122321084667422 0.2617259444426425 1.0 0.4431952108619875 27 P61978,P34913,Q9HB40,O14773,P42785,Q9H3G5 6 +F-type ATPase 0.561662284714618 1.1052258958751129 0.2690617185973516 1.0 0.4509878588140272 8 P00846 1 +Acyltransferase 0.514983820614938 1.0732101680734083 0.2831768295433461 1.0 0.4637195528271599 11 P49354 1 +Oxidase 0.4322037460003832 0.9485698578444884 0.3428394273731552 1.0 0.5246842044787009 19 P36551,Q15067,Q15800,O15260,O43169,O15254,Q6ZRP7 7 +Glycosylase 0.7947797716149979 0.9119918612329228 0.3617730019535523 1.0 0.5395384305203766 2 P78549 1 +DNA glycosylase 0.7947797716149979 0.9119918612329228 0.3617730019535523 1.0 0.5395384305203766 2 P78549 1 +Actin binding motor protein 0.526636344732789 0.9002867463648745 0.3679676724282148 1.0 0.5446907913531579 7 P06753,Q9Y4I1,O00159 3 +Oxidoreductase 0.3802935337063415 0.8671588592365518 0.385854974395055 1.0 0.5600734232325125 117 P03915,O94788,Q15067,Q15392,O95831,P30837,Q16850,Q8N8N7,Q14914,Q8N4Q0,Q14739,O15260,O15254,Q9H7Z7 14 +SLC56 Sideroflexins 0.7732463295269127 0.8316763994206703 0.4055916254642602 1.0 0.5760698026619453 2 Q96NB2 1 +SNARE protein 0.4498066154178026 0.8058118213287111 0.4203513608400433 1.0 0.5897378301693762 12 O95249,P56962,O15400,Q86Y82 4 +RSK family 0.7595432300163059 0.7814839472797502 0.4345179145094344 1.0 0.5998761208644137 2 Q15418 1 +RSK subfamily 0.7595432300163059 0.7814839472797502 0.4345179145094344 1.0 0.5998761208644137 2 Q15418 1 +Chromatin/chromatin-binding protein 0.3814330086181244 0.7711008056420809 0.4406471831217635 1.0 0.6037261199490461 24 O95400,O95619,Q8WVM7,O75446,Q8IXK0,Q8WXI9,Q9UBU8,Q29RF7,Q9UQR0,Q8N3U4,Q96GM5 11 +Calcium-binding protein 0.4072118931690595 0.7548847711464027 0.4503181240446217 1.0 0.6123340838582133 17 Q14257,P80303 2 +Kinase inhibitor 0.5388880203064286 0.7384919228806501 0.4602155736445434 1.0 0.6202769901053237 5 Q9UBW7,Q9NQG5 2 +DNA binding protein 0.3331432918957135 0.7208974367003078 0.4709726200730482 1.0 0.6279634934307309 60 Q9UBD5,P10412,Q00577,P16402,P20585,O95400,Q8IXK0,Q9Y5Q8,O95619,P07305,Q8WXI9,Q9UBU8,Q29RF7,Q8WVM7,O75446,P16403,Q9UQR0,Q8N3U4,Q96GM5 19 +Reductase 0.4005431397662122 0.7157714512251682 0.4741324832402604 1.0 0.6300637544663354 17 Q15392,Q14739,Q9UBM7,O95881,Q9H7Z7 5 +Reader 0.4314144186477914 0.7111645904077856 0.4769822483669972 1.0 0.6308986758174254 12 P45973,O60885,Q13185,P25440,Q6PL18,Q86U86 6 +Esterase 0.4287912350098791 0.5848841896134321 0.5586255901518054 1.0 0.6857750597586251 10 Q969T7 1 +Other group 0.4154046411800608 0.5763750163589063 0.5643617276126274 1.0 0.6886936545226142 11 Q96GD4 1 +Kinase modulator 0.3715032763002829 0.534092183154904 0.5932777576542101 1.0 0.7064382638193107 15 Q9NQG5,O00459,Q93052,Q9UBW7,Q5VT52 5 +Acetyltransferase 0.3560993999096744 0.5217193557879928 0.6018657459947963 1.0 0.7128514180707951 21 Q9BWD1,P23786,Q5VZE5 3 +Chromodomain 0.6710182767624207 0.4895903265366728 0.6244238230037662 1.0 0.7256540794625145 3 P45973,Q13185 2 +Translation initiation factor 0.3532440150752339 0.4725086122509394 0.636563795965396 1.0 0.732346417843658 19 O75153 1 +Nuclease 0.341936765079347 0.4676570287057768 0.6400298754028735 1.0 0.7344982669500001 36 Q13868,Q9UQ84,Q15024,Q6L8Q7,Q92667,Q5JSZ5,Q9UHB6 7 +Microtubule binding motor protein 0.3765195499628219 0.4446664238075299 0.656560837216861 1.0 0.7431425219608092 12 O00139,O95239,P33176,Q99661,Q13561,Q8NI77 6 +Ca2+-ATPases 0.6479608482871058 0.4135517002318077 0.6792024520506494 1.0 0.7492377892363533 2 P16615 1 +V-type ATPase 0.3949369183255465 0.3724525963000778 0.7095558998761244 1.0 0.7681713972224138 8 Q9Y5K8 1 +TK group 0.4782536279407309 0.3388247814060341 0.734741731512544 1.0 0.7780557116006699 4 P07948 1 +Glycosyltransferase 0.3250123578895207 0.3064928225549392 0.7592294438380236 1.0 0.7898980372043614 15 Q8TCJ2,P04844,O60762,Q8N128,Q8NAT1 5 +AGC group 0.3410053209801708 0.2300022577238138 0.8180900153359649 1.0 0.8340322823014863 10 P17252,Q13464 2 +Heterotrimeric G-protein 0.3511449149521862 0.2208512409122144 0.8252082640345517 1.0 0.8404272689040414 8 Q9UBI6,Q8NHH9,Q14344,P63218 4 +PKN family 0.567373572593788 0.2174447530164533 0.827861757558547 1.0 0.8426979897728578 2 Q16512 1 +RNA helicase 0.330382522762984 0.1952743514485267 0.8451781751211731 1.0 0.8594446097907377 10 Q7Z478,Q9BQ75,Q8IY37 3 +Zinc finger transcription factor 0.3505390395295631 0.1679998403844685 0.8665834046489922 1.0 0.8794118470863688 6 Q9Y2X9,Q8WU90,O95785,Q9NRM2,Q7Z3K3 5 +Exoribonuclease 0.3186980419720808 0.1294724472305092 0.8969838253530078 1.0 0.9084074604186344 8 Q6L8Q7,Q15024 2 +SLC12 family of cation-coupled chloride transporters 0.4900489396410901 0.1019323713225138 0.9188103551771384 1.0 0.9295648784183976 2 Q9Y666 1 +Protease 0.2895243202426935 0.0872332383512842 0.9304861196658988 1.0 0.9404201351783462 105 P61978,Q8NHP8,P34913,P55786,Q5JRX3,Q96RU2,Q9Y4W6,Q9HB40,Q10713,P22695,O14773,Q7Z2K6,P42785,Q9H3G5,O75844,Q96K76,P42892 17 +Nucleotide phosphatase 0.292968759162416 0.0785200520636723 0.9374143802245009 1.0 0.9469409491292212 9 Q8IWA4 1 +KRAB box transcription factor 0.4487597911227154 0.0724632216196679 0.9422332733906452 1.0 0.950842511421626 3 Q9Y2X9,O95785 2 +C2H2 zinc finger transcription factor 0.4487597911227154 0.0724632216196679 0.9422332733906452 1.0 0.950842511421626 3 Q9Y2X9,O95785 2 +Methyl-lysine/arginine binding protein 0.3013746513165905 0.0639463169177202 0.9490129721533088 1.0 0.9567128745642892 5 P45973 1 +Cytokine 0.3477977161500808 0.0363875081246145 0.9709733746567486 1.0 0.977859710647222 2 Q13123 1 +DNA helicase 0.2549083769633484 0.0267196921349573 0.9786833066865452 1.0 0.9851252727558744 11 P49736,P46063,P25205,Q14566,O60264,P33991,P28370,P13010,P33993,P12956 10 +Transporter 0.3558050046903018 0.0117496232293213 0.990625372730816 1.0 0.99664131628991 191 Q6NT16,Q9H2V7,P08183,O43772,Q8IXU6,P41440,O60645,P00846,O15439,Q6N075,P30825,P49755,Q9Y619,Q86Y82,Q9BQT8,Q8TAD4,Q99808,P28288,P53985,Q96S59,Q70HW3,Q9UPT5 22 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..46271caeee7d72b47065534224d450c239dac8b7 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome non-ATPase regulatory subunit 9", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S16, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3'-5' exoribonuclease 1", "3-Ketosteroid receptors", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L13, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L16, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L23, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L41, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "39S ribosomal protein S18a, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "5'-nucleotidase domain-containing protein 3", "5-formyltetrahydrofolate cyclo-ligase", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AK3 subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-1 complex subunit sigma-2", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit a", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 10, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "ATR subfamily", "AUR family", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 2/3 complex subunit 5", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-CoA-binding domain-containing protein 5", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine deaminase", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose 1-epimerase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Antigen peptide transporter 2", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Arfaptin-2", "Arginase-2, mitochondrial", "Armadillo repeat protein deleted in velo-cardio-facial syndrome", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "Aurora kinase b", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breakpoint cluster region protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK1 family", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 2", "CCR4-NOT transcription complex subunit 7", "CD166 antigen", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CRK7 subfamily", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcineurin-binding protein cabin-1", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium/calmodulin-dependent protein kinase type 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbonyl reductase family member 4", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Chaperone", "Chaperonin", "Charged multivesicular body protein 6", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "ClC-7/CLCN7 subfamily", "Class I transporters", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Copper-transporting ATPase 2", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Coronin-7", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cu+-ATPases", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 11b", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 13", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-g-associated kinase", "Cystathionine gamma-lyase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase alpha subunit B", "DNA polymerase epsilon subunit 2", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA repair protein complementing XP-C cells", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Derlin-2", "Desmocollin-3", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 2", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-3", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "Dystonin", "Dystroglycan", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase XIAP", "E3 ubiquitin-protein ligase ZNF598", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELMO domain-containing protein 2", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Endodeoxyribonuclease", "Endonuclease III-like protein 1", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelial protein C receptor", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Ephrin-B1", "Epidermal growth factor receptor substrate 15", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Erythrocyte band 7 integral membrane protein", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2 subunit 3", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 4", "Exocyst complex component 6", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Flavin reductase (NADPH)", "Folate transporter 1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GC-rich sequence DNA-binding factor 2", "GDP-L-fucose synthase", "GMP synthase [glutamine-hydrolyzing]", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTP-binding protein 2", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "Gap junction-forming innexin (innexin) family", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General vesicular transport factor p115", "Geranylgeranyl transferase type-1 subunit beta", "Geranylgeranyl transferase type-2 subunit alpha", "Glia maturation factor beta", "Glucocorticoid receptor", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycogen synthase kinase-3 beta", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgi pH regulator family", "Golgi ph regulator b", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Gtp:amp phosphotransferase ak3, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein G(o) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-11", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Hepatoma-derived growth factor-related protein 3", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone deacetylase complex subunit SAP30", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase NSD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Huntingtin-interacting protein 1", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin superfamily cell adhesion molecule", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol monophosphatase 3", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF18A", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF3A", "Kinetochore protein NDC80 homolog", "Kinetochore protein Nuf2", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit beta-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligand-dependent corepressor", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lipoma-preferred partner", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Long-chain-fatty-acid--CoA ligase 6", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAGUK p55 subfamily member 7", "MAP7 domain-containing protein 1", "MAPK family", "MCU family", "MFS-type transporter SLC18B1", "MHC class II regulatory factor RFX1", "MIF4G domain-containing protein", "MMS19 nucleotide excision repair protein homolog", "MST subfamily", "Magnesium transporter protein 1", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mediator of RNA polymerase II transcription subunit 14", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-bound signaling molecule", "Metal-response element-binding transcription factor 2", "Metallo-beta-lactamase domain-containing protein 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methionine aminopeptidase 1", "Methionine--tRNA ligase, mitochondrial", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Microfibrillar-associated protein 1", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1A", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial import inner membrane translocase subunit Tim22", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 3", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mortality factor 4-like protein 2", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 4", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 2", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "N-acetyl-D-glucosamine kinase", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 5", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurofibromin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Neutral amino acid transporter subfamily", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-14", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Non-structural maintenance of chromosomes element 3 homolog", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear envelope pore membrane protein POM 121C", "Nuclear factor NF-kappa-B p100 subunit", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor", "Nuclear receptor coactivator 5", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Origin recognition complex subunit 3", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PAKB subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PIN2/TERF1-interacting telomerase inhibitor 1", "PITSLRE subfamily", "PKA family", "PKC alpha subfamily", "PKC delta subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pannexin-1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP1A", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Peptidyl-prolyl cis-trans isomerase-like 3", "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal NADH pyrophosphatase NUDT12", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 3-kinase regulatory subunit beta", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylase b kinase regulatory subunit beta", "Phosphorylated adapter RNA export protein", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Prenylated Rab acceptor protein 1", "Presequence protease, mitochondrial", "Primase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable asparagine--tRNA ligase, mitochondrial", "Probable cysteine--tRNA ligase, mitochondrial", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable helicase with zinc finger domain", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Proteasome inhibitor PI31 subunit", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FAM177A1", "Protein FAM89A", "Protein FRG1", "Protein LSM14 homolog B", "Protein Mpv17", "Protein NDRG3", "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SEC13 homolog", "Protein SET", "Protein SYS1 homolog", "Protein Wiz", "Protein XRP2", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein kinase c alpha type", "Protein kinase c beta type", "Protein kinase c delta type", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1F", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein spinster homolog 1", "Protein strawberry notch homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24C", "Protein transport protein Sec24D", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pseudouridine-5'-phosphatase", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RIO family", "RIO2 subfamily", "RIPK family", "RNA 3'-terminal phosphate cyclase", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding motif protein, X-linked-like-1", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with multiple splicing", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab proteins geranylgeranyltransferase component A 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Rap guanine nucleotide exchange factor 6", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein R-Ras2", "Ras-related protein Ral-A", "Ras-related protein Ral-B", "Ras-related protein Rap-2b", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Rel homology transcription factor", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal dehydrogenase 2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoblastoma-associated protein", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-associated protein kinase 2", "Rho-related GTP-binding protein RhoG", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal RNA-processing protein 7 homolog A", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "Ribosome-recycling factor, mitochondrial", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "S1 RNA-binding domain-containing protein 1", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC18 family of vesicular amine transporters", "SLC19 family of vitamin transporters", "SLC2 family of hexose and sugar alcohol transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC30 zinc transporter family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC38 family of sodium-dependent neutral amino acid transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC5 family of sodium-dependent glucose transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC6 neurotransmitter transporter family", "SLC61 Molybdate transporter family", "SLC63 Sphingosine-phosphate transporters", "SLC7 family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRC family", "SRPK family", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "Sarcolemmal membrane-associated protein", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Sedoheptulokinase", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-6", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase atr", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase pak 4", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase rio2", "Serine/threonine-protein kinase tousled-like 2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase wnk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 6 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters", "Sodium-coupled neutral amino acid transporter 2", "Sodium-dependent HCO3- transporters", "Sodium-dependent multivitamin transporter", "Sodium-dependent neutral amino acid transporter B(0)AT2", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 12 member 7", "Solute carrier family 2, facilitated glucose transporter member 1", "Solute carrier family 35 member F2", "Sorbitol dehydrogenase", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Synaptosomal-associated protein 23", "Synaptosomal-associated protein 29", "Syntaxin-12", "Syntaxin-17", "Syntaxin-18", "Syntaxin-3", "Syntaxin-4", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "System A-like transporters", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TLK family", "TOPK family", "TP53-binding protein 1", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Testin", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1B", "Trafficking protein particle complex subunit 4", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription factor 20", "Transcription initiation factor IIA subunit 1", "Transcription initiation factor IIE subunit beta", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation initiation factor IF-2, mitochondrial", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 4", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Trophoblast glycoprotein", "Tropomodulin-1", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-3 chain", "Tubulin beta-4B chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Type II PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "Tyrosine-protein kinase lyn", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 36", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 5", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like modifier-activating enzyme ATG7", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Unconventional myosin-Va", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 26B", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 45", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuolar protein sorting-associated protein 52 homolog", "Vacuolar protein sorting-associated protein 72 homolog", "Vacuole membrane protein 1", "Very long-chain acyl-CoA synthetase", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WASH complex subunit 5", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "WNK family", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YEATS domain-containing protein 4", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 277", "Zinc finger protein 281", "Zinc finger protein 622", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zinc transporter 5", "Zinc transporter 7", "Zinc transporter ZIP14", "Zyxin", "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALYREF", "ANAPC1", "ANO6", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "ARCN1", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG7", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATXN2L", "AUP1", "AURKB", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCAT2", "BCKDK", "BCLAF1", "BCR", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRD2", "BRD4", "BRIX1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CAB39", "CABIN1", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CBR4", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC37", "CDC42", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKN2AIP", "CEBPZ", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHERP", "CHM", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT7", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCPS", "DCTN1", "DCTN2", "DDAH2", "DDB1", "DDI2", "DDOST", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLGAP5", "DLST", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "EPHA7", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAM177A1", "FAM89A", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP1A", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCFC2", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS2", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPDA1", "GNS", "GOLGA2", "GOSR1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GTF2A1", "GTF2E2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GUF1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LCOR", "LDHA", "LDHB", "LETM1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPP", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM6", "LYN", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARS2", "MAT2A", "MBLAC2", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "METAP1", "METTL1", "MFAP1", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF4GD", "MIPEP", "MMS19", "MORF4L1", "MORF4L2", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL38", "MRPL39", "MRPL41", "MRPL44", "MRPL47", "MRPL49", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NARS2", "NBN", "NCAPD2", "NCBP1", "NCL", "NCOA5", "ND5", "NDC80", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NDUFS8", "NEDD4L", "NEK9", "NF1", "NFKB2", "NHP2", "NISCH", "NKRF", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NR3C1", "NRBP1", "NRDC", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OLA1", "OPA1", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAIP1", "PAK2", "PAK4", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDHX", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGGT1B", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PINX1", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPT1", "POGZ", "POLA2", "POLDIP3", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PPA1", "PPA2", "PPAT", "PPIL1", "PPIL3", "PPM1F", "PPM1G", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKACA", "PRKAG1", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSMF1", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPRF", "PUDP", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB3GAP2", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAPGEF6", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBMX", "RBMXL1", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RNASEH2A", "RNH1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RTCA", "S100A11", "S100A13", "SAE1", "SAP18", "SAP30", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT2", "SHPK", "SIN3A", "SIRT1", "SKP1", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMN1*", "SNAP23", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPNS1", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TAP2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDRKH", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIMM22", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMOD1", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM40", "TOP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRMT61A", "TROVE2", "TRUB1", "TSFM", "TSG101", "TST", "TSTA3", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UCK2", "UGGT1", "UNC119B", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP19", "USP28", "USP36", "USP39", "USP47", "USP5", "USP7", "UTP11", "UTP14A", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS52", "VPS72", "VRK1", "VRK3", "WARS", "WASHC5", "WDHD1", "WDR1", "WDR33", "WDR82", "WIZ", "WNK1", "XAB2", "XIAP", "XPC", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS4", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF207", "ZNF277", "ZNF281", "ZNF598", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABCD3", "ACAT2", "ACOX1", "ACOX3", "ADK", "AFG3L2", "AIFM1", "AKAP1", "ALDH1A2", "ALDH1B1", "ATAD2", "ATL2", "ATP2A2", "ATP5B", "ATP6", "ATP6V1D", "AURKB", "BCAS2", "BCKDK", "BRD2", "BRD4", "CALU", "CASK", "CBX3", "CBX5", "CD2BP2", "CDK1", "CDK11B", "CDK13", "CDK2", "CIRBP", "CLUH", "CMSS1", "CPOX", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CYB5B", "CYB5D2", "CYP51A1", "DCTN2", "DHCR24", "DHCR7", "DHX29", "DHX37", "DPM1", "ECE1", "EFNB1", "EPHX2", "ERMP1", "EWSR1", "EXO1", "EXOC3", "EXOC7", "EXOSC2", "EXOSC7", "FAM177A1", "FN3KRP", "FNTA", "FUS", "GAK", "GATAD2B", "GNA13", "GNG12", "GNG5", "GOSR1", "GSK3A", "GSK3B", "GTF3C5", "H1F0", "H2AFX", "HDGFL2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HNRNPK", "IK", "KHDRBS3", "KIF18A", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LBR", "LIMA1", "LPP", "LSM6", "LYN", "MCM2", "MCM3", "MCM4", "MCM6", "MCM7", "MFN1", "MFSD5", "MORF4L1", "MPV17", "MPV17L2", "MSH3", "MSMO1", "MTA1", "MYO1C", "MYO5A", "NAA35", "NCL", "ND5", "NONO", "NPEPPS", "NT5C3B", "NTHL1", "NUCB1", "NUCB2", "ORC3", "P3H1", "P3H4", "PBRM1", "PDE12", "PDS5A", "PEX14", "PHC2", "PIK3R2", "PITRM1", "PKN1", "PLBD2", "PLK1", "PMPCA", "POGZ", "POMGNT2", "PRCP", "PRKCA", "PRPS2", "PRRC2B", "PSPC1", "PTGES2", "PTGR1", "PTGR2", "PURA", "PXMP2", "QKI", "QSOX2", "RANBP9", "RAVER1", "RBM14", "RBM3", "RBM4", "RBMX", "RBMXL1", "RBPMS", "RCN2", "RECQL", "ROCK1", "RPN2", "RPRD1B", "RPRD2", "RPS6KA1", "SAP30", "SCAF4", "SCARB1", "SCML2", "SCPEP1", "SFPQ", "SFXN2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A26", "SLC29A1", "SLC30A5", "SLC35F2", "SLC7A1", "SMARCA1", "SMARCA5", "SMARCD1", "SNRPA", "SPNS1", "SRSF1", "SRSF10", "SRSF3", "SRSF5", "SRSF7", "SRSF9", "STAG1", "STAG2", "STRBP", "STT3B", "STX12", "STX17", "STX7", "SUGP1", "SURF4", "TAF15", "TMED10", "TPM3", "TPP1", "TRA2A", "TRA2B", "TXNDC12", "UNC119B", "UQCRC2", "USP28", "USP47", "WIZ", "XAB2", "XRCC5", "XRCC6", "YEATS4", "ZADH2", "ZC3H15", "ZFR", "ZMPSTE24", "ZMYM2", "ZNF277", "ZNF281"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..6785abc7327d2c020d7960aeba6cc4801c3d75de --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:07a41b79d1508f2eeb72e2044514590a2a3fc0c92801aee05cd6a8e59cbc263f +size 67554 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7293a29c8326221280af5f0cb078bf699a190c98 --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 766.5 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..533a33feeb86790c82c7c85e374c9ae01b7a5a29 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..911c0f98110fcfc0055bf4e7c9370c039a6363c6 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2b92d566c6ec388645b977e511f82bfea7d0c45b --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C3orf58", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG4", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM89A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", 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"RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", 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1.308877373090359 0.190575892316662 0.9999999999999996 0.7808963392487616 45 Q16352,Q8WUJ1,P49840,P49841,Q8N5V2,P98172,Q969G3 7 +Amino-acid transport 0.5914004716302208 1.2444188137392025 0.2133454622093931 1.0 0.7846055962352838 8 Q9H9B4,Q15758,P30825,Q96NB2 4 +Hydrogen ion transport 0.4710099636032958 1.228317999322945 0.2193276167502955 1.0 0.7846055962352838 20 Q9Y5K8,P00846,P36543,P06576 4 +Symport 0.5421646185836153 1.060307882512539 0.2890045543395638 1.0 0.8239421556605022 9 P53985 1 +Sugar transport 0.8202283849918436 1.0087701700139695 0.3130848702315889 1.0 0.8239421556605022 2 Q96AA3 1 +Phagocytosis 0.8012621162748177 0.9081433833245672 0.3638024720534369 1.0 0.8239421556605022 3 P20339 1 +ATP synthesis 0.5112507893251963 0.8709008296439076 0.3838083037673439 1.0 0.8239421556605022 8 P00846 1 +Lipid transport 0.4224204088060646 0.864447519884229 0.3873420979110109 1.0 0.8239421556605022 18 Q9H4L5,Q99720,Q9H2V7 3 +Nucleotide metabolism 0.5007581372921919 0.8638483317040239 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Q16836,Q15067,P37268,P23786,P33121,Q14914,Q9UBM7,O15254,P42126,Q9NPH0,Q8NHP8,Q06136,O15118,Q8NCC3,Q8IVS2,Q16850,O95864,O14975,Q14739,Q9H7Z7,Q96G23,Q9BY49,P48651,Q15392,P27544,Q16880,P34913,P35610,Q96N66,P09960,Q15126,Q9UHB6 32 +Prostaglandin metabolism 0.6710545110874631 0.4896947408684403 0.6243499239011179 1.0 0.9089891291297548 3 Q9H7Z7 1 +Immunity 0.2938144176038506 0.4507276160723981 0.6521858760803272 1.0 0.9089891291297548 72 Q8WXF1,Q9NUD5,P07948,Q8N5M9,Q9BQ95,Q96CV9,P23246,Q13740,Q12899,P04439,Q15233,Q96PK6,O43823,Q9UQ84,P14174,Q6P179,Q9BWS9 17 +Fatty acid metabolism 0.3229392690427797 0.4044182833573524 0.6859051576301014 1.0 0.9089891291297548 49 Q9BY49,Q8NCC3,Q8IVS2,Q15067,P23786,P33121,O95864,Q14914,Q9H7Z7,O15254,P42126 11 +Exocytosis 0.3456506093377052 0.4027529868504396 0.6871299496599139 1.0 0.9089891291297548 15 Q9UPT5 1 +Biological rhythms 0.3317094642113092 0.4018703714357259 0.6877794288777102 1.0 0.9089891291297548 39 P06493 1 +Cilium biogenesis/degradation 0.3399093169028155 0.3830853082203361 0.7016565125906018 1.0 0.9089891291297548 17 O95721,Q9Y5K8,O95684,A6NIH7,Q9Y5Y2 5 +Mitosis 0.3232129623691843 0.3820103807368146 0.7024536648177164 1.0 0.9089891291297548 106 Q9H7Z3,Q96DE5,Q9H6H4,P06493,P24941,Q9ULW0,O75935,O00139,Q7Z4H7,Q9NQS7,Q96GD4,O43768,P49454,P12270,Q86XL3,P53350,Q29RF7,Q8NFH4,Q6IQ49,Q9NWV8,Q8WVM7,Q9UJX3,Q96CS2,Q53HL2,Q9H6D7,Q6P1K2 26 +Adaptive immunity 0.3064085288819909 0.2270481316114227 0.8203863157120013 1.0 0.9873175343463264 16 P04439,P07948,Q6P179 3 +Ion transport 0.2711207948261913 0.2134260759175416 0.8309946433734487 1.0 0.9873175343463264 63 P00846,P06576,P21796,Q6P4Q7,Q9H0H5,Q8TDW0,Q9Y5K8,Q8TAD4,Q6N075,P36543 10 +Cell shape 0.3440052270499862 0.1524575248482179 0.8788260890155137 1.0 0.99089116076917 6 P15311,P35579,Q7Z406,Q96AC1,P35580 5 +Notch signaling pathway 0.4833550913838104 0.1048011003501134 0.9165336369062208 1.0 1.0 3 Q96T58,Q92542 2 +Cell division 0.3216240428401951 0.0834019865750238 0.9335319089587016 1.0 1.0 139 Q96GD4,Q8WYP5,P49454,Q9H7Z3,Q9H0H5,Q6IQ49,Q96DE5,Q8WVM7,Q7Z4H7,Q86XL3,Q9H6D7,Q6P1K2,P53350,P06493,P24941,P53990,P50995,Q6DKK2 18 +mRNA capping 0.3183153770812966 0.0515231243171285 0.9589086757798722 1.0 1.0 4 Q09161,O43148,Q53F19 3 +Branched-chain amino acid catabolism 0.2783034257748792 0.0333522230782789 0.9733937089056262 1.0 1.0 2 Q6NVY1 1 +Innate immunity 0.2576108281865771 0.0101707932020388 0.9918850210422618 1.0 1.0 55 Q8WXF1,Q9NUD5,P07948,Q9BQ95,Q96CV9,P04439,Q12899,Q15233,Q96PK6,O43823,P14174,Q9BWS9 12 +DNA repair 0.2770606203894307 0.0009194288106424 0.9992664020505888 1.0 1.0 104 Q15004,Q9UBU8,Q96RU2,P09874,Q15233,P20585,Q9UQ84,Q68E01,P24941,P46100,P78549 11 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f8a521bf09e1dad56c1b5d10a7e2496a901a74d2 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Biological rhythms", "Biomineralization", "Blood coagulation", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Copper transport", "Cysteine biosynthesis", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Erythrocyte maturation", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Hemostasis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Keratinization", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN4", "ACTR3", "ADA", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8", "AKAP8L", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDOA", "ALDOC", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKLE2", "ANO6", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "API5", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARL8B", "ARMT1", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATR", "ATRX", "AUP1", "AURKB", "BABAM1", "BABAM2", "BAG3", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOD1L1", "BOP1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C1QBP", "CACYBP", "CAD", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CARS2", "CBR4", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC51", "CCDC59", "CCDC86", "CCDC93", "CCNB1", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPF", "CENPV", "CERS1", "CERS2", "CETN2", "CFL1", "CGGBP1", "CHAF1A", "CHAF1B", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "COG6", "COG7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPZ1", "COQ5", "COQ8A", "CORO7", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF16", "DCPS", "DCTN1", "DCTN3", "DCUN1D1", "DCXR", "DDB1", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DEGS1", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPYSL2", "DSC3", "DSG2", "DST", "DTNBP1", "DTYMK", "DUS2", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM162A", "FAM208A", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCFC2", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GHITM", "GINS2", "GINS3", "GINS4", "GM2A", "GMPS", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPI", "GPKOW", "GPR89B", "GRB2", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP3", "GTPBP4", "GUF1", "GYS1", "H2AFX", "HACD3", "HADH", "HADHA", "HADHB", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INTS13", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JUP", "KARS", "KAT7", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIF11", "KIF18A", "KIF18B", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "LAMB1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPGAT1", "LPP", "LRP1", "LRPPRC", "LRRC41", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1S", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METTL1", "MFAP1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MIA3", "MICAL3", "MICU1", "MID1", "MIF", "MIF4GD", "MINDY3", "MKI67", "MLEC", "MMS19", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MRE11", "MRGBP", "MRPL41", "MRPL58", "MRPS27", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYCBP", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA15", "NAE1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NFKB2", "NGEF", "NHP2", "NIP7", "NISCH", "NKRF", "NLE1", "NME1", "NME2", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPLOC4", "NPM1", "NR3C1", "NRDE2", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NTHL1", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OGDH", "OGT", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PANK4", "PANX1", "PAPOLA", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK1", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PECR", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHKB", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN1", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLIN3", "PLK1", "PLRG1", "PMF1", "PMVK", "PNKP", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POP1", "PPAT", "PPHLN1", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1R8", "PPP2R1A", "PPP4R2", "PPP5C", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRELID1", "PRIM1", "PRIM2", "PRKAG1", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP2", "RANBP3", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM14", "RBM15", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCOR1", "REEP4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN3", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RTCB", "RTF1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SON", "SORT1", "SPC24", "SPC25", "SPEN", "SPNS1", "SPTLC1", "SPTLC2", "SRCAP", "SREK1", "SRM", "SRPK1", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STK4", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNGR2", "SYS1", "TAF6L", "TALDO1", "TAMM41", "TAP2", "TARDBP", "TARS", "TARS2", "TARSL2", "TBCB", "TCEA1", "TCERG1", "TCF20", "TDP2", "TDRKH", "TECR", "TEFM", "TERF2", "TERF2IP", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TK1", "TLK2", "TLN1", "TMCO1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM214", "TMEM30A", "TMEM41B", "TMX1", "TMX4", "TNPO1", "TNPO3", "TOLLIP", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TP53", "TP53BP1", "TPI1", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT112", "TRMT61A", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSR1", "TTC19", "TTC26", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB2B", "TUFM", "TWF2", "TXLNA", "TXLNG", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UFD1", "UFL1", "UFSP2", "UGDH", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS52", "VPS72", "VRK1", "VTA1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WDR12", "WDR33", "WDR36", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WTAP", "XAB2", "XIAP", "XPC", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "ZBED4", "ZC3H11A", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZMYM2", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ACOX1", "ACOX3", "ACP6", "ACSL1", "ADA", "AHCTF1", "AKAP8", "ALCAM", "ANAPC16", "ANAPC7", "ANKLE2", "ANXA11", "ATP5B", "ATP6", "ATP6V1D", "ATP6V1E1", "ATRX", "AURKB", "BABAM1", "BICD2", "CDCA8", "CDK1", "CDK2", "CENPF", "CERS1", "CERS2", "CHID1", "CNNM4", "CPT2", "CYB5D2", "CYP51A1", "DCTN3", "DHCR24", "DHCR7", "DMAP1", "ECI1", "ECSIT", "EFNB1", "ENSA", "EPHX1", "EPHX2", "ERAP2", "EXO1", "EXOC7", "EZR", "FADS2", "FDFT1", "FECH", "FERMT2", "FGFR1OP", "GSK3A", "GSK3B", "HADH", "HAUS1", "HAUS4", "HAUS6", "HIBCH", "HLA-A", "INA", "INCENP", "INTS3", "IST1", "JAGN1", "KDSR", "KIF2A", "LBR", "LIMA1", "LRRC8C", "LTA4H", "LYN", "MBOAT7", "MCAT", "MFSD5", "MIF", "MORF4L1", "MRGBP", "MSH3", "MTAP", "MYH10", "MYH14", "MYH9", "NCBP1", "NCBP3", "NCSTN", "NDC1", "NGEF", "NONO", "NPC1", "NRDE2", "NSMCE3", "NT5C3B", "NTHL1", "NUBP2", "NUP37", "OPTN", "OSBPL3", "PARP1", "PCLAF", "PDS5A", "PECR", "PEX14", "PEX3", "PLA2G15", "PLBD2", "PLK1", "PMF1", "PMVK", "PPOX", "PSPC1", "PTDSS1", "PTGES2", "PTGR1", "RAB5A", "RACGAP1", "RBM14", "REEP4", "RFT1", "RNMT", "SDE2", "SFPQ", "SFXN1", "SFXN2", "SIGMAR1", "SIL1", "SLC16A1", "SLC1A5", "SLC27A2", "SLC30A5", "SLC7A1", "SMARCE1", "SNAP29", "SOAT1", "SPEN", "SPNS1", "STAG1", "TIMM17A", "TIMM17B", "TOMM22", "TPR", "TPX2", "TRAM1", "TRIM26", "TTC19", "UGT8", "UNC119B", "USP28", "VDAC1", "ZCCHC3"]} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/advanced/idx2term.json b/protein_atlas_disease_involvement/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/protein_atlas_disease_involvement/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/basic/idx2term.json b/protein_atlas_disease_involvement/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..916e6a868bffcd7b9e42f05231db753b6c77c21a --- /dev/null +++ b/protein_atlas_disease_involvement/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Dwarfism", "1": "Deafness", "2": "Primary mitochondrial disease", "3": "Limb-girdle muscular dystrophy", "4": "Proto-oncogene", "5": "Neuropathy"} \ No newline at end of file diff --git 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b/protein_atlas_disease_involvement/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d0675fc9d4c821ad44ba215f813ab471e29cfd3c00266585b396dd9f53ee8322 +size 72765 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b349371504a853ec28f6efa06c6afdf6bbba699c --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Diabetes mellitus 2 9 1.977394043420188 0.0479971067576612 3.1966019417475726 10.315533980582524 0.6190680538080506 0.4730085508812801 1.8480344075927575 1.973723369210009 0.8597438282474712 0.3113207504672028 0.0631212919045741 0.01497108596825 0.0548237001435711 0.0678108138951911 0.2936288791787133 diff --git 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b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..89bda777641de58ded4c535417f67e9a5683f7b5 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,37 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Alzheimer disease 0.9418182063053556 2.058432321216473 0.0395486517711933 0.9903468821192812 0.4334893877341303 4 P49840 1 +Diabetes mellitus 0.7371108747430651 1.977394043420188 0.0479971067576612 0.9965053728279764 0.4334893877341303 9 P49840,P49841 2 +Dwarfism 0.5055328691228714 1.835741039715779 0.0663959652013543 0.9996295643340136 0.5090357332103835 43 O75718,O95831,Q32P28,Q96HY6,Q14739,Q96PZ0 6 +Amyotrophic lateral sclerosis 0.6063676054926043 1.7410265676593473 0.0816789216702229 0.9999444896996827 0.5760428659631595 13 Q99720,P50995,Q96CV9,P35637 4 +Leber hereditary optic neuropathy 0.9676998368678612 1.58845311141903 0.1121839157522854 0.9999988593668148 0.5930792912473026 2 P00846 1 +Zellweger syndrome 0.8117415252298816 1.5606097442278974 0.1186158582494605 0.9999995056873712 0.5930792912473026 4 O75381 1 +Peroxisome biogenesis disorder 0.8117415252298816 1.5606097442278974 0.1186158582494605 0.9999995056873712 0.5930792912473026 4 O75381 1 +Retinitis pigmentosa 0.5186842919868717 1.258906068814495 0.2080642615375569 0.9999999999977648 0.8599628160453194 13 O75695,P00846 2 +Osteogenesis imperfecta 0.5634124289232968 1.1619044040180726 0.2452742980326723 0.9999999999999912 0.8599628160453194 9 Q32P28,O75718,P07237 3 +Hirschsprung disease 0.8541598694942805 1.140135299502963 0.2542299375917629 0.9999999999999978 0.8599628160453194 2 P42892 1 +Charcot-Marie-Tooth disease 0.4060711639386145 0.9442500916159372 0.3450418631807341 1.0 0.8599628160453194 24 P54802,O95831 2 +Congenital disorder of glycosylation 0.4368074295377537 0.9317551768732693 0.3514630639489566 1.0 0.8599628160453194 17 Q8TCJ2,Q8N511 2 +Glaucoma 0.7738874794721082 0.8146665347595019 0.4152632140767858 1.0 0.925885483196342 3 Q96CV9 1 +Ehlers-Danlos syndrome 0.7673735725937858 0.8100703080439218 0.417899768203779 1.0 0.925885483196342 2 Q9NWM8 1 +Deafness 0.3710930825848577 0.7740620707261815 0.4388940859588377 1.0 0.925885483196342 47 Q13217,Q15067,Q9NR28,O95831,Q96GW9,Q16740,Q9NWM8 7 +Dystroglycanopathy 0.5441795629878207 0.7594749746733117 0.4475684786464042 1.0 0.925885483196342 5 Q8NAT1 1 +Primary mitochondrial disease 0.3470127280194635 0.71588613773048 0.474061658698139 1.0 0.925885483196342 98 O95831,Q99797,Q6DKK2,P14927,P00846,Q9HA77,Q96GW9,Q9Y606,Q9BQT8,P22695,Q8NI60,P39210,Q5ST30,Q5U5X0,P03915,Q9Y584,Q8N183,Q70HW3,O00217,P08574,P00403,O43676 22 +Leigh syndrome 0.4402643183267091 0.6958604547181101 0.4865162247728785 1.0 0.925885483196342 11 P00846 1 +Allergen 0.7318107667210425 0.682547524864601 0.4948928023971239 1.0 0.925885483196342 2 O43290 1 +Emery-Dreifuss muscular dystrophy 0.5205946223748064 0.6669163701465374 0.5048255538163113 1.0 0.925885483196342 5 Q9BTV4,P50402,Q8WXH0 3 +Congenital muscular dystrophy 0.4921396174675604 0.647173690814959 0.5175195366405447 1.0 0.925885483196342 6 O60762,Q8NAT1,P02545 3 +Limb-girdle muscular dystrophy 0.4353389034233462 0.5656513710011353 0.5716307988770006 1.0 0.925885483196342 9 O14979,Q15149,Q5JTV8,P02545,Q8NAT1 5 +Proto-oncogene 0.3459708432260865 0.5340704610240571 0.5932927857096015 1.0 0.925885483196342 44 Q06136,P07948,Q03164,P12270,Q16204,Q92804,P17252,P35637,Q96T37,Q01105 10 +Dystonia 0.4422488510140901 0.533121760052469 0.5939492969835902 1.0 0.925885483196342 7 P11166,O75569,Q15043,P35270 4 +Schizophrenia 0.6810703575143497 0.5188886994691034 0.6038383586063101 1.0 0.925885483196342 3 Q9NTZ6 1 +Neuropathy 0.3335983005179828 0.4771153759120379 0.6332799662669979 1.0 0.9357202128670054 48 Q13217,P00846,Q15067,O95831,P54802 5 +Lissencephaly 0.3950540302900354 0.4366791668954281 0.6623440399470679 1.0 0.9429706879522 10 Q8NAT1,O00139,P07942,Q9Y320 4 +Glutaricaciduria 0.4779627815866669 0.3380096248964944 0.7353559346106919 1.0 0.9825617494502108 4 P38117,Q16134,Q92947 3 +Gaucher disease 0.5797716150081446 0.2427565064409127 0.8081940306181483 1.0 1.0 2 P07602 1 +Ciliopathy 0.3510149612944748 0.2204467258476647 0.8255232583624963 1.0 1.0 8 P49454,P49959 2 +Rhizomelic chondrodysplasia punctata 0.4792822185970516 0.0913756684385874 0.9271940946275136 1.0 1.0 2 O00116 1 +Cockayne syndrome 0.476998368678618 0.0892939280748463 0.9288483194891644 1.0 1.0 2 P19447 1 +Fanconi anemia 0.4407830342577444 0.0630109093375809 0.9497578171903522 1.0 1.0 2 Q9NVI1 1 +Alport syndrome 0.4388254486133703 0.0619196299935364 0.9506268350178984 1.0 1.0 2 P35579 1 +Hereditary nonpolyposis colorectal cancer 0.4146818923327835 0.0508042206256163 0.9594815276495254 1.0 1.0 2 P52701 1 +Systemic lupus erythematosus 0.3234334203655425 0.0265808085056827 0.9787940804452702 1.0 1.0 3 P05455,P12956 2 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d6e8aa6dd5806e27d5780f27bf561d922b50891a --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Phenylketonuria", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pseudohermaphroditism", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", 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"signature_size": 3067, + "annotations_size": 97, + "title": "Average number of proteins per term", + "value": 37.7319587628866 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d874a5121081030a4c8e8d2fef468a009435e91b --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..eab9b9d0d3a1ec3bea8f3806eb3a9bc6578d95f7 --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,25 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine/threonine-protein kinase 0.5227211161836294 2.1733123170224284 0.0297568190902381 0.946615139413461 0.4314849185055215 50 Q96GD4,Q14004,O14936,P49840,Q13464,P49841,P17252,O14976,P53350,P06493,P24941,P21127 12 +Serine protease 0.7279846969559245 1.87321491628662 0.0610387133596206 0.9977775827056344 0.4314849185055215 8 Q16740,Q4J6C6 2 +Carboxypeptidase 0.7435011380872242 1.7276418729578005 0.0840524507463325 0.999799807094544 0.4314849185055215 6 P42785,Q9HB40 2 +Monooxygenase 0.8296891377743734 1.6303403977790152 0.1030295739811553 0.9999737289128788 0.4314849185055215 4 Q16850,Q9BU89 2 +Protease 0.3967997079797643 1.5609995665985616 0.1185238531277925 0.9999951535385132 0.4314849185055215 75 Q5JRX3,Q9Y4W6,P55786,Q96RU2,P28074,Q4J6C6,Q9HB40,O14773,Q7Z2K6,P42785,Q16740,Q9H3G5,O75844,P42892,Q99436 15 +Metalloprotease 0.4818148833684705 1.4836346590574925 0.1379058693641726 0.999999439204182 0.4314849185055215 26 Q5JRX3,P55786,Q9Y4W6,Q7Z2K6,P09960,O75844,P42892 7 +Kinase 0.4126559703450461 1.4700672381874194 0.1415435443533126 0.9999996278891982 0.4314849185055215 96 Q9HA64,Q96GD4,O14874,Q14004,P49840,P49841,P11908,Q8NI60,P55263,P06493,P24941,P53350 12 +Signal transduction inhibitor 0.9428412973636188 1.4106377858378958 0.1583514440777187 0.9999999453379502 0.4423022399916183 3 P49840 1 +Receptor 0.4608337597257793 1.4064397228891663 0.159593591749553 0.9999999526339176 0.4423022399916183 39 Q99720,Q9UNN8,P30825,P06493,Q8WTV0 5 +Host cell receptor for virus entry 0.5161856462435801 1.3649731368994438 0.172261493276032 0.9999999891448346 0.4641490235493085 15 P06493 1 +Translocase 0.4657968321869927 1.3191029706040924 0.1871346901969257 0.9999999981301652 0.4706548419071333 23 P03915,Q13423,Q9HD20,P06576,P08183,O15439,O00217,P08574 8 +Acyltransferase 0.4572253539263046 1.3175441516218578 0.187656291738999 0.9999999982430368 0.4706548419071333 32 P35610,Q8NCC3,O75600,Q9BWD1,P23786 5 +Myosin 0.5028680592499383 0.873772354903267 0.3822422384004968 1.0 0.7130287908624653 9 O00159,Q9Y4I1,Q7Z406,P60660,P35580 5 +Exonuclease 0.4056366129175071 0.8334061551178301 0.4046157045214391 1.0 0.7358274713332476 21 Q9Y3B8,P49959,Q9UQ84,Q6L8Q7,Q9BQ61 5 +Endonuclease 0.4053365655726582 0.7807249696857756 0.4349642713874491 1.0 0.7671188059015012 19 Q12972,Q9UQ84,Q15631 3 +Oxidoreductase 0.4103234417784407 0.6797418386218778 0.4966679393769233 1.0 0.822553424568042 170 P36551,O94788,Q15067,O95831,Q8NBX0,P30837,Q8N8N7,Q14914,Q8N4Q0,Q9UBM7,Q9UHG3,O15254,Q06136,Q9BU89,Q32P28,O15460,Q16850,P30519,Q6UW02,O95864,Q14739,P50336,Q9NRG7,Q9BY49,Q15392,P48735,Q8IXB1,Q99536,P13674,Q8NB78 30 +Protein phosphatase inhibitor 0.7069190600522293 0.5970685943610752 0.550461584733291 1.0 0.8753241593299873 3 Q12972,O43768 2 +Glycosyltransferase 0.3368951558127719 0.4358040007190658 0.6629789409246789 1.0 0.9273643817766468 32 P09874,Q13126,Q8NAT1,Q8TCJ2 4 +Threonine protease 0.643920947970365 0.4141114528343936 0.6787924856303291 1.0 0.9273643817766468 3 Q99436 1 +Nuclease 0.323778691497286 0.3460147237793621 0.7293316494613395 1.0 0.9537513060502998 38 O15091,Q9Y3B8,P49959,Q15631,Q9UQ84,Q6L8Q7,Q12972,Q9BQ61 8 +rRNA-binding 0.3017259562852152 0.2082635122887093 0.8350232199470766 1.0 1.0 17 Q9H9Y2,Q9NUL7 2 +Developmental protein 0.2732769601010419 0.2077131602322098 0.8354529414096943 1.0 1.0 76 Q16352,P85037,Q96C57,P49454,Q9BX40,Q9H0H5,P49841,Q8N5V2,Q8NB78,Q99426,P98172 11 +Repressor 0.297787383617787 0.0740145385277501 0.9409988169191306 1.0 1.0 115 Q9H0E3,P85037,Q14966,P18615,Q15233,Q96PK6,Q9HD42,Q12972,O14979,O15164,Q9NX63,Q9BUJ2,Q9H3P2,Q9UBK9,Q5VUA4,Q13217,Q16629,P23246,Q13185,Q8NEY8,Q8WXI9,Q9NPF5,Q14011,Q13242,P61978,Q8WXF1,P38159,O75446,Q5PRF9,P62995,Q8NB78,Q9UQR0,P67809 33 +Heparin-binding 0.289774583469462 0.0522611946439105 0.9583205732281316 1.0 1.0 6 P10586,P30533,P47914,O94813,P35268 5 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8994ba2391a86e51a3669b908174046aae62031c --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgG-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Potassium channel", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCC4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "ATR", "ATRX", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BANF1", "BAZ1B", "BAZ2A", "BCAT2", "BCKDHA", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BPHL", "BPNT1", "BPTF", "BRD1", "BRD2", "BRD4", "BRMS1L", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C12orf43", "CABIN1", "CAD", "CALD1", "CALR", "CAMK1", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBR4", "CBX3", "CBX8", "CCAR1", "CCAR2", "CCDC47", "CCDC51", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CERS1", "CERS2", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHM", "CHMP1A", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIRBP", "CKB", "CKMT1A*", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP2", "CTDSPL2", "CTH", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CUL5", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCD", "DCPS", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EFNB1", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERMP1", "ERO1A", "ERP44", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "F11R", "FADS2", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDE1", "GDI1", "GDI2", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLCE", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C5", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL3", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INF2", "IQGAP1", "IQGAP2", "IRF2BPL", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIAA1147", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KRR1", "L2HGDH", "LAMP1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD3", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "M6PR", "MACF1", "MAGED2", "MAN2A1", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MATR3", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST2", "MGST3", "MICAL3", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MTA1", "MTA2", "MTAP", "MTF2", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTR", "MUT", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NARS2", "NAT10", "NAXE", "NCBP3", "NCL", "NCOA5", "ND5", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NF1", "NFKB2", "NGEF", "NHP2", "NIFK", "NIP7", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRDC", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "OSGEP", "OTUB1", "OTULIN", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDE8A", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM7", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHKB", "PI4K2A", "PIAS2", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PMF1", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R8", "PPP3CA", "PPP4C", "PPP5C", "PPT1", "PPT2", "PPWD1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS2", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSMD9", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALB", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RFX1", "RHOT1", "RHOT2", "RIC8A", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP7A", "RRP8", "RRP9", "RSF1", "RTCA", "RTCB", "RTF1", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAP30", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT2", "SHPK", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A2", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAF15", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TK1", "TKT", "TLK2", "TMCO1", 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"VPS4A", "VPS4B", "VPS72", "VRK1", "WARS", "WARS2", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WNK1", "WTAP", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "ZADH2", "ZBED4", "ZC3H14", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFR", "ZMPSTE24", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687"], "leading_proteins": ["ABCB1", "ABCC4", "ACAT2", "ACOX1", "ACOX3", "ADK", "AFG3L2", "AIFM1", "ALDH1A2", "ALDH1B1", "ATP13A1", "ATP5B", "AURKB", "BCKDK", "C12orf43", "CASK", "CBX3", "CDK1", "CDK11B", "CDK13", "CDK2", "CENPF", "CHCHD3", "CHMP1A", "CIRBP", "CLPP", "COQ8A", "CPOX", "CPT2", "CPVL", "CYC1", "CYP20A1", "CYP51A1", "DDX28", "DHCR24", "DHCR7", "DMAP1", "DNAJC10", "DNAJC3", "DOHH", "ECE1", "EFNB1", "ENSA", "ERMP1", "EXO1", "FADS2", "FN3KRP", "FOXK1", "GAK", "GATAD2B", "GCAT", "GSK3A", "GSK3B", "HMOX2", "HNRNPDL", "HNRNPK", 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0000000000000000000000000000000000000000..188deb847da6408ac08cdb0f02e9ac04c438468f --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:221c1c527d4f924c3fcca23ccd18cebc59a27a397c8bbdfe51db9c69d49b4376 +size 82772 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..adf0bfc421ab9e671e92327cb30a7083ff6942bb --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted secreted proteins 8 49 2.690094980351761 0.0071431685217218 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 0.0727150512522393 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0000000000000000000000000000000000000000..ed16460bceb7e0c15be4a06ee0418a08c1495a8f --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..86a7601307a8da9f679fee628831c4e1268c1e65 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,8 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted secreted proteins 0.5892896326100324 2.690094980351761 0.0071431685217218 0.1397608655309335 0.0541563005251677 49 O60888,Q8WUJ1,O75718,Q9HB40,Q15165,Q9UMX5,P80303,P14174 8 +Enzymes 0.282044478450201 2.0995661898306888 0.0357670195745432 0.5346050994378623 0.1877768527663518 869 P07099,O94788,Q13126,P49840,P08183,P30837,P42785,Q8N8N7,Q8N4Q0,P06493,P24941,Q9UHG3,O15254,Q9NPH0,Q06136,P55786,P30520,Q14004,Q4J6C6,Q15165,Q8NCC3,P28070,P49841,Q9BU89,Q32P28,Q16850,P14174,P55263,O75844,P42892,P49721,P46100,Q99436,Q9H7Z7,P50336,Q96GD4,P49354,Q96G23,Q969T7,P22830,Q15392,Q8NI60,P53350,P48735,Q9NUJ1,Q9HA64,P34913,P03915,O14874,P35610,Q9HB40,P09874,Q9BWD1,Q16740,Q9H3G5,Q9NWM8,Q8TCJ2,P28074,Q15067,P37268,O60725,P11908,P23786,P33121,Q14914,P21127,O15091,O15439,O15460,O75600,P30519,P54802,Q14739,Q9BY49,P22695,P00813,Q9NUL7,Q15084,P52788,Q7Z2K6,P78549,Q96RU2,Q10713,P13674,P20339,Q15126,Q8NB78,Q9NX62,Q5JRX3,P36551,P07237,O14936,Q9UBM7,Q9H773,Q9BW91,P42126,P13667,Q9Y4W6,Q9Y680,P06576,O14773,Q8IVS2,Q96GW9,O95864,O14975,Q8IY37,Q96K76,O95881,Q12873 109 +Candidate cardiovascular disease genes 0.6344906834634982 1.5008195550485526 0.1334022393989133 0.9505497136288912 0.3578172540661953 9 Q15165 1 +Metabolic proteins 0.2663142602416947 1.33971990898613 0.1803364224387953 0.9846415148269742 0.4207849856905225 846 P07099,O94788,Q13126,P08183,O43772,Q8NBX0,P30837,P41440,Q8N4Q0,P06493,P24941,Q8WTV0,Q9UHG3,O15254,Q9NPH0,Q06136,P55786,P00846,P30520,Q14004,Q15165,Q8NCC3,Q16850,P30825,P14174,P55263,O75844,Q9H7Z7,P50336,Q96GD4,P49354,Q96G23,Q9BQT8,Q969T7,P22830,Q15392,Q99808,P27544,P53350,P48735,P53985,Q9UMR5,Q9HA64,P34913,P03915,O14874,P35610,Q70HW3,P09874,Q8N6R0,Q9BWD1,Q9NWM8,O43676,Q9H0E3,Q9BTX1,Q8TCJ2,O00459,Q15067,P37268,O60725,P11908,P23786,P33121,Q14914,P21127,Q9BW71,O15439,O15460,O75600,P30519,P54802,Q14739,Q9Y619,Q9BY49,Q8WYP5,P22695,P00813,Q15084,P52788,P28288,Q96RU2,Q96N66,Q10713,P13674,Q15126,Q9NX62,P36551,P07237,O14936,Q9UBM7,Q9H773,Q9BW91,Q99426,P42126,P13667,Q9Y680,P06576,O15118,O14773,Q8IVS2,Q96GW9,O95864,O14975,Q96K76,P36543 105 +CD markers 0.4063260606327746 0.7356634420929815 0.4619355430161627 0.999997774024401 0.9700646403339416 16 P08183 1 +Human disease related genes 0.232246850355986 0.3311778622276656 0.7405101409770294 0.9999999999995028 1.0 887 P07099,O75718,Q9NR77,P08183,O43772,O95831,Q99720,Q06136,P00846,Q14004,Q4J6C6,Q32P28,Q96HY6,Q8N511,P14174,P55263,O75844,P42892,P46100,Q9H7Z7,P50336,Q9BQT8,P22830,Q15392,Q86XL3,P27544,Q8NI60,P48735,P53985,Q5U5X0,P03915,O14874,Q8N183,Q70HW3,P38159,Q9UPT5,Q16740,Q9NWM8,O43676,Q8TCJ2,O00459,Q15067,P23786,P35637,Q6DKK2,P50995,P98172,Q969G3,Q9H173,Q13428,Q9H061,Q8TDW0,Q9Y4I1,O75381,O15460,P54802,Q14739,Q96F07,Q9Y2V7,Q16625,Q13217,Q9Y619,P49454,P22695,P00813,P52788,P28288,P39210,P61978,Q96N66,Q92796,Q6P4Q7,Q10713,Q9NR28,Q8WVM7,Q15126,P07942,Q9NX62,P36551,P08670,P07237,O14936,Q15233,Q00577,P20585,Q9UBM7,Q96PZ0,P50402,Q9Y4W6,O15118,O14773,Q96GW9,Q8IY37,Q9GZY8,P36543,P56589,Q8TD16,P48651,P12270 99 +Disease related genes 0.2292247020274548 0.3233494967098769 0.7464305725761635 0.9999999999996938 1.0 997 P07099,O75718,Q13126,P08183,O43772,O95831,Q99720,Q06136,P00846,Q14004,Q4J6C6,P28070,Q32P28,Q96HY6,Q8N511,P14174,P55263,O75844,P42892,P46100,P50336,Q96GD4,Q9BQT8,Q9H6R7,P22830,Q15392,Q92804,Q86XL3,P27544,Q8NI60,P53350,P48735,P53985,Q5U5X0,P03915,O14874,Q8N183,Q70HW3,P38159,Q8N6R0,Q16740,Q9NWM8,O43676,P10412,Q8TCJ2,O00459,Q15067,P37268,P23786,P35637,Q6DKK2,P50995,P98172,Q969G3,Q12792,Q9H173,Q13428,Q9H061,Q9Y4I1,O75381,O15460,P54802,Q14739,Q96F07,Q9Y2V7,Q96T37,Q16625,Q13217,Q9Y619,P49454,P22695,P00813,P52788,P28288,Q6UN15,P39210,P78549,P61978,Q5VU43,Q96N66,Q92796,Q6P4Q7,Q10713,Q9NR28,Q8WVM7,Q15126,P07942,Q9NX62,P36551,P08670,P07237,O14936,Q15233,Q00577,P20585,Q9UBM7,Q96PZ0,P50402,Q9Y4W6,O15118,O14773,Q96GW9,Q8IY37,Q9GZY8,Q12873,P36543,P56589,Q8TD16,P48651,P12270 110 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..058cbf49b8a9e1e22b17fdef451e9fd811c4027a --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Nuclear receptors", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL5B", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "B4GAT1", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDHA", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C3orf58", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHERP", "CHID1", "CHM", "CHMP1A", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM89A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI2", "GNAI3", "GNAO1", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GXYLT1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "IRS4", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYRM7", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED24", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMADHC", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND5", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NT5DC3", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX16", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POMGNT2", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB31", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERAC1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMIM12", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM160", "TMEM161A", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM41B", "TMEM43", "TMEM65", "TMEM70", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13D", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS52", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFC3H1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABCD3", "ABHD10", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ADA", "ADK", "ADSS", "AFG3L2", "AHCTF1", "AIFM1", "ALDH1A2", "ALDH1B1", "ANKLE2", "ANXA11", "ATP5B", "ATP6", "ATP6V1E1", "ATRX", "AURKB", "BCKDK", "BICD2", "CASK", "CDK1", "CDK11B", "CDK13", "CDK2", "CENPF", "CERS1", "CERS2", "CHD3", "CLPP", "CNNM4", "COG6", "COQ8A", "CPOX", "CPT2", "CPVL", "CRTAP", "CUTA", "CYB5D2", "CYFIP2", "CYP51A1", "DCTPP1", "DDRGK1", "DDX28", "DHCR24", "DHCR7", "DHX37", "DIABLO", "DLG3", "DNAJC3", "DOHH", "ECE1", "ECI1", "EFNB1", "EMD", "EPHX1", "EPHX2", "ERMP1", "EXOC7", "FADS2", "FDFT1", "FECH", "FIP1L1", "FKBP14", "FKBP7", "FN3KRP", "FNTA", "FUS", "GCAT", "GSK3A", "GSK3B", "HIRIP3", "HIST1H1E", "HMOX2", "HNRNPK", "ICMT", "IDH2", "IMPAD1", "KDM1B", "KDSR", "KIAA0391", "LAMB1", "LBR", "LRRC8C", "LYRM7", "MARS2", "MBOAT7", "MCAT", "METTL13", "MFF", "MIF", "MPV17", "MSH3", "MTAP", "MYO5A", "NAGLU", "ND5", "NDC1", "NDUFAF2", "NDUFB3", "NENF", "NONO", "NPC1", "NPEPPS", "NT5C3B", "NTHL1", "NUCB2", "NUDT9", "OCLN", "P3H1", "P4HA1", "P4HA2", "P4HB", "PARP1", "PCYOX1", "PDE4DIP", "PDIA4", "PDIA6", "PECR", "PEX14", "PEX3", "PIK3R2", "PITRM1", "PLA2G15", "PLK1", "PMPCA", "PMVK", "PON2", "PPOX", "PPT2", "PRCP", "PREPL", "PRPS2", "PSMB2", "PSMB4", "PSMB5", "PSMB7", "PTDSS1", "PTGES2", "PTGR1", "PTGR2", "PURA", "PUS7", "PXMP2", "RAB5A", "RBM15", "RBMX", "SAP130", "SCARB1", "SCCPDH", "SCPEP1", "SIGMAR1", "SIL1", "SLC16A1", "SLC19A1", 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+size 72805 diff --git a/protein_atlas_subcellular_location_all/df_merge.tsv b/protein_atlas_subcellular_location_all/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..41ad33157f1c1c3fc637a188788d568a958877cb --- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Focal adhesion sites 4 27 3.006555326785444 0.002642259657408 6.264563106796117 27.364077669902912 0.2615680943966604 0.640618977052225 3.6431084765940094 3.1857496524893976 0.758529337646141 0.3146129005339539 0.0084178166544246 0.0614819278885333 0.0481208533269518 0.0528572065128901 0.1128690321722891 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..519af3e49643ab7d0cbb1da27f084d9f816f52fe --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3067, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 142.1818181818182 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..92b91984f7d0a8cf169ef82fe4a2e2e3e03ed155 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C432/C432_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fc1d5fbb6f38ae76af42ec63be0c56113e608e16 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,10 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Focal adhesion sites 0.7062527343339208 3.0065553267854437 0.002642259657408 0.0836070003139955 0.0435972843472328 27 O60888,P08183,Q9Y3B8,Q9UHB6 4 +Peroxisomes 0.5994862608325461 1.915456198840478 0.0554343499922198 0.8477136826860042 0.4573333874358138 17 Q9BY49,Q15067,O75381,P28288,O15254 5 +Nuclear membrane 0.3583158700424599 1.1449777560123553 0.2522183718970137 0.9999316768152308 1.0 64 Q9BTX1,Q9BVC6,Q9BW91,Q9Y5Q9,P50402,Q9BTZ2,Q96SK2,Q8IY37,Q14739,O15260,Q14728,Q96G23,O95619,Q8WYP5,P12270,A8CG34,Q9UKD2,Q8IXM6,Q6UW68 19 +Mitotic chromosome 0.3993938269682655 0.8895945663512185 0.3736836248952668 0.9999998031233118 1.0 35 Q9NYH9,Q7L5D6,Q13601,Q6PK04,Q9H6F5,Q14684,P19338,Q13895,Q76FK4,Q14137,Q99848,Q9Y3B9,Q5QJE6,Q9UMY1 14 +Actin filaments 0.3350686000485141 0.4888652513446968 0.6249370981652349 0.9999999999999912 1.0 48 Q9BTX1,O75718,Q6P4Q7,Q6WCQ1,Q6UW02,Q9UHB6 6 +Nuclear speckles 0.3351732765492853 0.3085842170705452 0.7576378282593448 1.0 1.0 126 Q9H0E3,P10412,Q6NSI4,Q92841,Q15233,P11908,Q96PK6,P21127,Q12972,Q9NYF8,Q92733,P98175,O95400,Q14004,Q7Z4H7,Q16630,Q5T8P6,O75600,Q92766,Q96SK2,Q9Y2V7,Q86VM9,Q7Z6E9,Q14139,O43290,Q9P2N5,Q9P275,Q9P013,Q15024,Q9UBU8,P82979,Q14157,Q15750,Q6IQ49,Q93050,O75934,P25440,P31949,Q9BU76,Q9Y2W1 40 +Intermediate filaments 0.28913758958884 0.1485476462467106 0.8819105867525106 1.0 1.0 33 Q16352,O75718,P08670 3 +Centrosome 0.2662173948939849 0.1185213077926401 0.9056546129083732 1.0 1.0 60 Q15004,P28074,P55081,Q69YU5,P24941 5 +Centriolar satellite 0.2459639288205531 0.0187279131585455 0.9850581606768448 1.0 1.0 24 Q00013,Q9Y4I1,Q7Z4H7,O43169,Q12873 5 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cae7d21bd9e9b6f81824ff2d076d4e8ed51ed815 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ADA", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC5", "ARVCF", "ASCC1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1B3", "ATP2B1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATR", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKB", "BABAM1", "BABAM2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT2", "BCCIP", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOD1L1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CABIN1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC127", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC51", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5RAP3", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPI", "CENPP", "CENPV", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHCHD4", "CHD1", "CHD1L", "CHD3", "CHD4", "CHD7", "CHD8", "CHID1", "CHM", "CHMP1A", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG6", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COQ5", "COQ8A", "CORO1B", "COTL1", "COX15", "COX4I1", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB12", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOHH", "DPF2", "DPP3", "DPP9", "DPY19L3", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DTNBP1", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFNB1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELP1", "ELP2", "ELP3", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM3C", "FAM49B", "FAM50A", "FAM89A", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXO3", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLB1", "GLCE", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNE", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GPAA1", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2A1", "GTF2E2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C5", "GTPBP1", "GTPBP2", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HGH1", "HGS", "HIBCH", "HINT2", "HIP1", "HIRIP3", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BPL", "IRGQ", "ISOC1", "ISOC2", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JAGN1", "JAM3", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMP2", "LAMTOR1", "LANCL1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCOR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMF2", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LPP", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBLAC2", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MESD", "METAP1", "METTL1", "METTL13", "METTL17", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD3", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MIF4GD", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL23", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL44", "MRPL46", "MRPL47", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS11", "MRPS15", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTF2", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NARS2", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEFL", "NEFM", "NELFA", "NELFCD", "NELFE", "NEMF", "NES", "NF1", "NFATC2IP", "NFKB2", "NFU1", "NGEF", "NHLRC2", "NIF3L1", "NIFK", "NIP7", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR3C1", "NRBP1", "NRDC", "NRDE2", "NRM", "NSA2", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSL1", "NSMCE1", "NSMCE2", "NSUN2", "NSUN5", "NT5DC1", "NT5DC3", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OPTN", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PANX1", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE4DIP", "PDE8A", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKB", "PI4K2A", "PIAS2", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POM121C", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4C", "PPP4R2", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID1", "PREP", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPRT", "QSOX2", "QTRT2", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAPGEF2", "RAPGEF6", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RFX1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK2", "RIOX1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHPK", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A7", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A5", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC5A6", "SLC6A15", "SLFN11", "SLIRP", "SLK", "SLMAP", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMDT1", "SMIM12", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD2", "SNRPD3", "SNTB2", "SNW1", "SNX1", "SNX2", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPATA5L1", "SPATS2L", "SPC24", "SPC25", "SPCS2", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRIP1", "STRN", "STT3B", "STUB1", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOC7", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMEM109", "TMEM126A", "TMEM161A", "TMEM167A", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM41B", "TMEM70", "TMOD3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIM4", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT112", "TRMT2A", "TRMT61A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC37", "TTC38", "TTC4", "TTF2", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13D", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS72", "VRK1", "VRK3", "VTA1", "WARS", "WARS2", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR77", "WDR82", "WIZ", "WNK1", "WTAP", "XAB2", "XIAP", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZBED4", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCCHC8", "ZFC3H1", "ZFR", "ZFYVE16", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF207", "ZNF277", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCD3", "ACOX1", "ACOX3", "AHCTF1", "ATP6V0A1", "BCAS2", "BCLAF1", "BOP1", "BRD2", "BYSL", "C12orf73", "C1orf35", "CCDC137", "CCDC86", "CD2BP2", "CDK11B", "CDK13", "CDK2", "CERS2", "CHD3", "CNNM4", "COG6", "CPSF6", "CRTAP", "CUTA", "CWC15", "CXorf57", "CYB5B", "CYP20A1", "DDX17", "DHRS4", "DHX37", "DNTTIP2", "EBNA1BP2", "EMD", "EXOSC7", "GCAT", "GET4", "GTF3C3", "HAUS6", "HIST1H1E", "INA", "KRR1", "LBR", "LIMA1", "MFAP1", "MFSD10", "MORF4L1", "MPP1", "MPRIP", "MRTO4", "MYO5A", "NCL", "NDC1", "NOL7", "NOL8", "NONO", "NRM", "NUDT9", "PCLAF", "PECR", "PEX14", "POM121C", "PPP1R8", "PRCC", "PRPS2", "PSMB5", "RBBP6", "RBM10", "RBM14", "RBM26", "RBM27", "REXO2", "RREB1", "RRP15", "RRP1B", "S100A11", "SAP130", "SARNP", "SART1", "SDE2", "SURF4", "TAB1", "THRAP3", "TMEM109", "TMEM205", "TMEM209", "TPR", "UBAP2L", "UBE4A", "USP36", "UTP6", "VIM", "YEATS4", "ZC3H18"]} \ No newline at end of file