File size: 9,657 Bytes
d1d02d4
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
Dna irdamage and cellular response via atr	4	31	2.601731873322294	0.009275433873408	11.368932038834952	35.29854368932039	-0.5571161533496566	0.5286960221336726	6.506516958951914	4.2335573207288775	0.9558756700654956	0.346850563426156	0.00026096311242	0.0059462173176447	0.0065863767611137	0.0386631533679294	0.1700618733952761
Type i collagen synthesis in the context of osteogenesis imperfecta	4	12	2.528437326435569	0.0114571539998256	3.929611650485437	12.026699029126211	0.5177909587737206	0.4899443091771766	2.065057615656466	0.7083179697775124	0.9693193629839164	0.3218513942404959	0.0393012238682757	0.0058373227860703	0.0224191931510111	0.0024379570615939	0.0052134507581354
Mitochondrial long chain fatty acid betaoxidation	5	14	2.469131995806684	0.0135441248584624	3.349514563106796	13.533980582524272	0.7147062657958151	0.3986109248220331	2.228276960109081	1.0526483843060723	1.0135677936233438	0.2846338064127241	1.0	0.0742352733278267	0.144637307685789	0.0004862334359502	6.703246650942136e-05
Mirna regulation of dna damage response	3	21	2.464056604197262	0.0137374414758077	6.997572815533981	23.76941747572815	-0.0927742871867072	0.6297630627489007	3.799909801182797	3.3700186756541433	0.7986845515233213	0.2977741953481899	0.005271608704837	0.0038595506966638	0.0038034373632918	0.0756483536674149	0.2160232841208998
Dna damage response	3	20	2.43822976391747	0.0147593895116939	6.825242718446602	22.76941747572815	-0.1047399916281437	0.6179341114552384	3.624825899979946	3.3700186756541433	0.8102402020510112	0.2962122153795926	0.0049642787567718	0.0035377598965085	0.0034028502394037	0.0691718370159023	0.1985748090604032
Ketogenesis and ketolysis	3	6	2.371778734461613	0.0177026884738962	1.8349514563106797	5.844660194174757	1.1440476930797234	0.2688274513424756	1.082491618646365	0.8448275696235764	0.860272390139093	0.2373824405295798	1.0	0.0331691185540615	0.0018987369599165	1.1110147517061663e-05	0.0001708540892308
Dna mismatch repair	1	16	2.3634617888275997	0.0181050936270743	5.160194174757281	19.174757281553397	0.1547408857460915	0.5270932325531026	3.4632001533411247	1.960419929584235	1.0139907215610702	0.3153217325311915	0.0425098423004131	0.0068317681715133	0.0260710687649276	0.1300982938321277	0.3621483333283614
Cholesterol metabolism with bloch and kandutschrussell pathways	9	21	2.3627125052778983	0.0181417371177652	7.092233009708738	23.070388349514563	1.3045876527781233	0.2885598195159411	3.1892169450204397	2.132138915277104	1.1515799969949023	0.3088028425519339	1.0	1.0	0.0498890213657128	2.226230744371199e-06	7.06610764140417e-06
Influence of laminopathies on wnt signaling	5	11	2.361175000788707	0.0182171317341384	2.929611650485437	10.199029126213592	1.172665957836072	0.274405530989148	1.5096443497648335	1.3031697834850824	0.8784257604250459	0.2713478851839423	1.0	0.134742527043449	0.0029806631250197	0.0056128198685199	0.0027845492980534
Neural crest differentiation	1	8	2.358465668877872	0.0183506570904188	2.121359223300971	8.480582524271844	0.2184651498610498	0.5347394603612715	2.120136947648397	1.523954886345698	0.8663287650790108	0.2803232757223193	1.0	0.0335548880884004	0.1151189883762866	0.4288192611001937	0.795813225928823
Atm signaling pathway	1	13	2.3557753451397274	0.0184840926008467	5.725728155339806	14.978155339805824	-0.4845531915333449	0.565875901017388	3.04895624411497	2.0519960670928907	0.732253277081457	0.2994249617469091	0.0016839157720017	0.0135379522122687	0.0498890213657128	0.2256009180273313	0.2668248172965894
Vitamin a and carotenoid metabolism	1	5	2.2484507334713686	0.0245474632407418	1.0606796116504855	4.106796116504855	0.9332890102257668	0.3070288768360753	0.8805930946368925	1.0255249317378814	1.0615219291263185	0.2652373693874932	1.0	0.0032958763634803	0.012905013470629	0.0693365470158766	0.2166689846253057
Statin inhibition of cholesterol production	2	5	2.2321531233094305	0.0256048443937793	2.0315533980582523	5.029126213592233	1.044092701346018	0.2144191485801186	1.2890406286437517	1.2084356467042294	1.2621579412510306	0.2395890160394713	1.0	0.0652597674910206	0.1277572387780678	0.0041946485896371	0.0277461310389573
Omega3 omega6 fatty acid synthesis	3	6	2.220405128833508	0.0263912792148657	2.186893203883495	5.679611650485437	0.6147861513210825	0.4189854893383595	1.4636445594342842	0.6147632306564689	0.961935437880314	0.3073297118149702	0.0181972414507802	0.0516364610584135	0.1018169846714528	0.0020064706347618	0.0013781701696679
Overlap between signal transduction pathways contributing to lmna laminopathies	4	16	2.2044852155578907	0.0274902385688713	4.927184466019417	14.766990291262136	1.2077866030529698	0.2877996039599693	1.943257907759383	1.4611731122572065	0.935661776029738	0.2919054664837305	1.0	0.1952735388158895	0.0093807730237194	0.0230341265569123	0.020723717832043
G1 to s cell cycle control	2	23	2.199052835101234	0.0278741656589063	6.900485436893204	24.733009708737864	0.2427705123410361	0.6554568890773506	4.5732760832124555	3.009947532023907	0.8058923051029326	0.3212929414660505	0.004094381550339	0.0315268496209905	0.1088269092294783	0.1655021226103433	0.5396622799916891
Cholesterol biosynthesis with skeletal dysplasias	3	5	2.1897760147693264	0.028540485052122	2.703883495145631	6.024271844660194	1.6250539245333766	0.1427602110791373	1.3052115351448448	0.7101163612316155	0.9675759117714408	0.205892393525391	1.0	1.0	0.0018987369599165	0.0004573905935078	0.0001708540892308
Male infertility	3	19	2.181756468075004	0.029127510937382	4.771844660194175	21.143203883495147	0.0444814370323583	0.5560383924350045	2.840652101933473	2.673381449757451	0.8805323935686871	0.3007001850197258	0.1135831106778655	0.0049299691055274	0.0327043685536917	0.096818905200251	0.4653980221544829
Nrp1triggered signaling pathways in pancreatic cancer	1	10	2.179562601994179	0.0292898994997914	3.5242718446601944	10.155339805825244	-0.1581030855894588	0.5627629700317509	2.497939578871497	2.3013600096987736	0.8375438042065276	0.2894955313304667	0.0017757260688105	0.0142466262053111	0.0523352985295366	0.2345960405017343	0.5569491745948094
Cell cycle	6	45	2.1716974477560376	0.0298784911757425	13.604368932038836	49.62135922330097	0.0249984674289128	0.7560897539313539	7.374930003933479	5.628665372951865	0.6307917639367615	0.2837424250752632	0.0146052019149518	0.0164824785433421	0.0046116462239443	0.0189568719932508	0.3013722093479412
Wnt signaling pathway	1	11	2.136116072171825	0.0326699540415971	3.9563106796116503	12.050970873786408	-0.1668721405390101	0.6077108119526166	2.6112218582109348	2.3264673893512393	0.8231911322186768	0.2957072479206077	0.0709369996773478	0.0188245552589776	0.0678620701894922	0.2887846572413305	0.1636366172223574
Progeriaassociated lipodystrophy	3	10	2.130913653136861	0.0330962563819632	2.5606796116504853	9.87135922330097	0.8348691672738174	0.3132697473637388	1.651332949166155	0.8732569863233294	1.0627007810416775	0.2700069969953336	1.0	1.0	0.012905013470629	0.0007869115437374	0.0097510399506001
Integrated cancer pathway	2	12	2.057575856260911	0.0396308662750688	5.533980582524272	14.570388349514564	-0.1404285602316551	0.6609702247616228	3.450947622721706	2.757583866580215	0.6906701888261467	0.2846381743249511	0.0023755233326464	0.0188245552589776	0.0088166073526355	0.0901467992310857	0.1636366172223574
Fatty acid betaoxidation	5	21	2.037186525263422	0.0416313536461372	5.162621359223301	19.570388349514563	0.1995607006787997	0.4670713659716193	3.5273220572363555	1.315478001889997	1.0772652457386651	0.2899601798313401	1.0	0.134742527043449	0.2540772386550496	0.0056128198685199	0.0027845492980534
Eicosanoid metabolism via cyclooxygenases cox	3	6	2.0243100256869995	0.0429382627170276	2.1723300970873787	5.970873786407767	-0.5997976144138961	0.3148044959908401	1.0869532585081771	0.910630963157096	1.2684242485629602	0.2767828501620498	0.0198359893050149	0.0014481500629001	0.0057815105752346	0.000142755965642	0.0019884945269669
Angiopoietinlike protein 8 regulatory pathway	4	27	2.011816260527047	0.0442393092146451	7.575242718446602	28.25242718446602	0.0554077707393526	0.6876386171429575	4.071171283635633	4.140654342084138	0.7247314269394591	0.2975639551036786	0.1643017062783413	0.0145949948181238	0.0857236814467353	0.1179506058012683	0.4191175542383009
T cell receptor and costimulatory signaling	1	7	2.001725694354153	0.0453142413792608	2.004854368932039	4.997572815533981	0.0830042136398081	0.610725986843673	1.434652871703374	1.6480332297169549	0.8275331080085909	0.2993058931533784	0.0296145418928731	0.0032958763634803	0.012905013470629	0.0693365470158766	0.0539281835546241
Small cell lung cancer	2	8	1.996233871162689	0.0459084722403162	3.895631067961165	12.45873786407767	-0.0228219556353496	0.6257817052219004	2.6349555254635137	3.2613872739529466	0.7561717293401203	0.2839951877209646	0.1254250484281346	0.3208381238265493	0.5432530093799623	0.5811837748974361	0.7527687502855307
1q211 copy number variation syndrome	1	9	1.9858808343933227	0.047046557301742	1.866504854368932	8.890776699029127	0.7558686703595463	0.4317742326000632	1.7233813053885791	1.5024938423345304	0.794994669182033	0.2981691736709426	1.0	0.0875404472016038	0.1693528922958147	0.0762921742488627	0.2348875720984273
Constitutive androstane receptor pathway	0	5	1.9633695275452376	0.0496032519392488	1.3470873786407769	5.580097087378641	0.3129409554034168	0.503782578475575	1.3789035541989327	0.7477422264229717	0.9528192116668128	0.3098481746082029	0.0279911849957302	0.0786913117950012	0.152955667850895	0.3411306657380243	0.5711774547855736