The Hives set up by the influential Umbrella Corporaton has been secretly conducting genetic experiments and the subterranean lab has unfortunately been plagued by a viral outbreak, taking its toll on the working staff. It is up to Milla Jovovich and Michelle Rodriguez with the assistance of cop Eric Mabius to confront and isolate the virus. Accompanying them is an elite task force - and the situation is critical with the time factor going against them. They have to reach the Red Queen, the mother of the computer network that powers and defend the Hive.