A deadly virus has escaped into a underground scientific colony owned by the Umbrella Corporation killing all the researchers and employees, a lovely woman named "Alice" ( Milla Jocovich) is joined with "Rain" ( Michelle Rodriguez) and a elite commando squad to investigate the mysterious deaths of the workers. They discover that the computer that runs the place has taken over and accidently unleashes hordes of zombies & mutant monsters, they must find a way out or else end up as dinner before the virus will infect humanity.