Set after the events of the original movie, Alice ( Milla Jovovich)has came out of the hospital in Raccoon City to find the entire population of the city has been sealed off and contaminated by the T-virus. She meets up with survivors including Jill Valentine and Carlos whom are part of the S.T.A.R.S. alpha team of the police station, they together must escape the city of horrors or end up dead by zombies, mutants and a powerful new foe called "Nemesis".