A few seconds after the first film concluded, this one takes off with Alice (Milla Jovovich) wandering a zombified city after some idiots from the Umbrella Corporation decide to reopen The Hive for a little peek.  Apparently, they couldn't trust the reports that told them they needed to keep that place locked tight, permanently.  With the zombies taking over, the EVIL villain in charge (Thomas Kretschmann as Major Cain) decides to seal off the city and destroy it with a nuclear missile, then call it an accident, despite film footage stating otherwise.  Can the last few survivors manage to get out in time and in one piece?  And exactly just what is Program Alice?