I bought this creme at a little store in Squaw Valley, CA, when desperate to find something, anything!, to help me heal after having suffered from angular cheilitis. I developed a badly cracked lip area after an intense dental procedure. Once the yeast infection was gone (that's what causes cheilitis), my skin would still crack open and bleed because the area around the mouth has to be moved so much. The derma e Cracked Skin Relief was apparently stocked in Squaw Valley for the many skiers, but it was a heaven's send for my cheilitis as well. The creme stings a bit when first applied but goes to work immediately. I applied it often and had great results. My face surrounding the cracked lip area was very read and flaking, really unsightly, for at least two weeks. Whith the derma e product, I was able to heal over the weekend. Terrific stuff!