Ticket to Ride is amazing.  It is simple enough that my 6 year old daughter can play, but has complex layers that make it fun for me.  It is a game for the whole family that we can play again and again.  Choose your tickets (destinations) and build your train route between the locations, but watch out, others can block your path making you take a longer route.  This game has tons of replay value and is a great game for the whole family!