"Twilight Imperium: Rex" by Fantasy Flight Games is a wonderful science-fiction themed game set in the Twilight Imperium Universe.  Up to six players vie for control of Mecatol Rex, the capital city of the declining Lazax Empire.  What's cool here is that each of the races competing for control has unique advantages.  The Xxcha can make predictions about the game, the Federation of Sol knows where the bombarding human fleet will travel to next, the Hacan get money every time anyone deploys troops, etc...  The battle engine is a lot fun, where each side has to commit a set number of troops while adding an officer with an additional combat rating.  Each side is able to pick a traitor, which they can use against one enemy in battle.  This traitor mechanic adds a fun level of paranoia to the game that delivers a unique degree of tension.  The only real complaint is the Hacan advantage seems a little strong, and might lead to some balancing issues with repeated play.  Based on the original "Dune" mechanic, this game is a fun game that will provide hours of entertainment.