I use a primer before applying and then I use a round buffer foundation brush to apply. I swirl the brush in the Dermablend and then buff it onto my face. I finish applying my make-up and then set with Make Up For Ever HD setting powder and it stays until I wash my face without budging. I haven't tried the Dermablend setting powder but I am sure it is similar. I use NARS tinted moisturizer for more sheer coverage and the Dermablend for my full-on days :) Love it