The first sign with all multivitamins, etc. is, if your urine turns bright neon. If it does, you just lost everything you thought will be kept in your body. This one does and in my opinion a big waste of hard earned $. Kind of heavy on the stomach as well. I'm taking a different shake, not interested in promoting it, so I won't mention it. None the less, it is light years ahead of this one.... let's just leave it at that. Do some more extensive research on MEAL Replacements, you'll stumble across the product I'm currently using with no "neon urine" afterwards :-) P.S: Even tried their pills with the same effect.