I love these journals.  I've wasted so much money on different notebooks and paper, etc trying to nail down a note system perfect for me.  Since discovering Moleskine I've completely changed the way I compose and organize my notes for classes; the large size is the perfect size for transferring info from large index cards.  The major upside is that I no longer have to carry around a bunch of loose and thick 5X8 cards which saves space and weight in my backpack.  I use one cahier journal per chapter in chemistry, one journal per chapter in math, and keep classic Moleskine notebooks for overall important course notes.  All unruled paper, but I would buy the dot-grids if they made cahier journals with them.  I've never been more organized and less bogged down by a meticulously complex system.  They're perfect because I like to keep my most important notes on things around 5X8 size rather than standard letter-sized paper.  The only thing I struggle with is my love of Levenger circa system; I still use their notebooks for problem solving, there is nothing better for the job.  So I keep both Moleskine and Levenger; combined, they're pretty pricey but more than worth it.