Hoffmann bromamide degradation reaction
Hoffmann developed a method for preparation of primary amines by
treating an amide with bromine in an aqueous or ethanolic solution
of sodium hydroxide In this degradation reaction, migration of an
alkyl or aryl group takes place from carbonyl carbon of the amide
to the nitrogen atom The amine so formed contains one carbon less
than that present in the amide Write chemical equations for the following conversions:
(i) CH3–CH2–Cl into CH3–CH2–CH2–NH2
(ii) C6H5–CH2–Cl into C6H5–CH2–CH2–NH2
Example 9