degree from the
University of London Since this reaction requires the approach of the nucleophile to the
carbon bearing the leaving group, the presence of bulky substituents
on or near the carbon atom have a dramatic inhibiting effect Of the
simple alkyl halides, methyl halides react most rapidly in SN2 reactions
because there are only three small hydrogen atoms Tertiary halides
are the least reactive because bulky groups hinder the approaching
Configuration
Spacial arrangement of functional groups around carbon is called its configuration