The Seasiders' Andy Taylor came close to the opening goal after five minutes, curling just over from 20 yards.
Wycombe were denied by the woodwork in the 25th minute as Michael Harriman's looping 20-yard strike came back off the crossbar.
Harriman came close again nine minutes later but sent a header straight at goalkeeper Sam Slocombe, while at the other end Brad Potts met Mark Cullen's cross but nodded wide from three yards.
Wycombe started the second half on the front foot as Adebayo Akinfenwa brought the ball down and unleashed a powerful 25-yard strike which was inches over the bar.
On the hour mark, a cleverly-worked low corner created a chance for Blackpool but Potts fired over from eight yards.
The hosts almost snatched a winner in the 81st minute, forcing Blackman to produce a fingertip save to deny Cullen from 12 yards before the on-loan Chelsea youngster pushed Jim McAlister's 25-yard strike wide.
Report supplied by Press Association.
Match ends, Blackpool 0, Wycombe Wanderers 0.
Second Half ends, Blackpool 0, Wycombe Wanderers 0.
Attempt missed. Kelvin Mellor (Blackpool) right footed shot from the left side of the box misses to the right following a corner.
Corner,  Blackpool. Conceded by Joe Jacobson.
Attempt blocked. Mark Cullen (Blackpool) right footed shot from the centre of the box is blocked.
Attempt blocked. Armand Gnanduillet (Blackpool) left footed shot from outside the box is blocked.
Corner,  Wycombe Wanderers. Conceded by Jim McAlister.
Corner,  Blackpool. Conceded by Jamal Blackman.
Attempt saved. Jim McAlister (Blackpool) right footed shot from outside the box is saved in the bottom left corner.
Corner,  Blackpool. Conceded by Jamal Blackman.
Attempt saved. Mark Cullen (Blackpool) left footed shot from the left side of the box is saved in the top left corner.
Paul Hayes (Wycombe Wanderers) is shown the yellow card.
Corner,  Blackpool. Conceded by Anthony Stewart.
Attempt blocked. Brad Potts (Blackpool) right footed shot from the centre of the box is blocked.
Colin Daniel (Blackpool) wins a free kick in the defensive half.
Foul by Sido Jombati (Wycombe Wanderers).
Attempt missed. Kelvin Mellor (Blackpool) header from the centre of the box is close, but misses the top right corner following a corner.
Corner,  Blackpool. Conceded by Aaron Pierre.
Attempt missed. Paul Hayes (Wycombe Wanderers) header from the centre of the box is just a bit too high.
Attempt missed. Armand Gnanduillet (Blackpool) left footed shot from the right side of the box is close, but misses to the left.
Foul by Colin Daniel (Blackpool).
Sido Jombati (Wycombe Wanderers) wins a free kick on the left wing.
Substitution, Wycombe Wanderers. Paul Hayes replaces Adebayo Akinfenwa.
Attempt missed. Marcus Bean (Wycombe Wanderers) right footed shot from outside the box misses to the right.
Attempt blocked. Nick Freeman (Wycombe Wanderers) right footed shot from the left side of the box is blocked.
Danny Pugh (Blackpool) is shown the yellow card.
Foul by Danny Pugh (Blackpool).
Marcus Bean (Wycombe Wanderers) wins a free kick in the attacking half.
Clark Robertson (Blackpool) wins a free kick in the attacking half.
Foul by Adebayo Akinfenwa (Wycombe Wanderers).
Substitution, Wycombe Wanderers. Matt Bloomfield replaces Dan Rowe because of an injury.
Substitution, Blackpool. Armand Gnanduillet replaces Bright Samuel.
Substitution, Wycombe Wanderers. Dayle Southwell replaces Garry Thompson.
Attempt missed. Brad Potts (Blackpool) right footed shot from the centre of the box is close, but misses to the right following a corner.
Corner,  Blackpool. Conceded by Dan Rowe.
Attempt missed. Joe Jacobson (Wycombe Wanderers) left footed shot from outside the box misses to the right.
Jim McAlister (Blackpool) wins a free kick in the defensive half.
Foul by Marcus Bean (Wycombe Wanderers).
Corner,  Wycombe Wanderers. Conceded by Andy Taylor.
Foul by Colin Daniel (Blackpool).
Blackpool and Wycombe played out a goalless draw at Bloomfield Road, with the visitors having goalkeeper Jamal Blackman to thank for a string of late saves.