The Gran Fondo was in the city for the first time, giving riders the option of taking on a 100 mile (160km) course or a shorter 37 mile (60km) route.
Plymouth based cyclist Jonathan Tiernan-Locke, who is serving a two-year doping ban, was among the riders.
The Sky Ride offered families the chance to cycle a 5 mile (8km) tour of the city.
Thousands of bikers in Devon took to the streets as two big cycling events came to Plymouth.