The 27-year-old man from Blackburn was riding a grey Triumph Daytona motorcycle along the B6479 near Selside when he crashed at 19:25 BST on Wednesday.
The air ambulance was called but the biker died at the scene.
The road was closed for five hours to allow collision investigators to examine it.
A motorbiker has died after hitting a sign at the side of the road in North Yorkshire.