She was a passenger in a car that collided with a lorry on the Legacorry Road at about 15:35 GMT on Thursday.
The woman who was driving the vehicle is in a critical condition in hospital.
In a separate incident, Moor Road in Coalisland, County Tyrone, has been closed following a two-vehicle crash.
A 20-year-old woman has died in a crash in Richhill, County Armagh.