The 26-year-old has tweeted that she can "only take so much" and seems to have broken up with the singer via social media.
It follows claims he fathered a child with another woman.
According to US website TMZ, Chris Brown became a dad nine months ago with his friend and former model Nia.
The site claims the pair have known each other "for several years" and that Chris is "happy" to be a dad.
TMZ also says Chris and Nia are not together, but are on "very good terms".
It's been a turbulent four years for Chris and Karrueche, with the pair splitting up on several occasions before getting back together.
But Karrueche has tweeted that this time she has had enough of the drama.
Newsbeat has contacted representatives for Chris Brown, but has not received a response so far.
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She has been the long suffering girlfriend of Chris Brown, but after four rocky years Karrueche Tran says enough is enough.