Synchronised wreath-laying ceremonies will take place in counties Cork, Meath, Wexford, Galway and Dublin, beginning at 09:45 local time in Cork.
Thousands of people lined the streets of Dublin on Sunday for a parade to mark the centenary.
The commemoration events have been organised by the Irish government.
The rebellion is viewed as a seminal event in the founding of the state.
The Easter Rising was quelled within six days by British troops, but despite its failure it is seen as a significant stepping stone to the eventual creation of the Republic of Ireland and the partition of Ireland.
More than 450 people were killed and 2,500 injured during the fighting.
A weekend of events to mark the centenary of the Rising began on Saturday with a remembrance ceremony in Dublin at which Irish president Michael D Higgins laid a wreath.
Wreaths were also laid in Dublin at Kilmainham Gaol, where 14 of the Rising's leaders were executed, and at the Sigerson Monument in Glasnevin Cemetery, which is dedicated to to all those who lost their lives in the Rising.
The synchronised wreath-laying ceremonies on Monday have been organised by the Irish Department of Arts, Heritage and the Gaeltacht (Irish-speaking areas).
The locations and times are:
Then, at 12:30 local time, wreaths will be laid at various buildings and landmarks around the Irish capital that became focal points during the rebellion.
They include Boland's Mill, Jacob's Factory, Dublin Castle/City Hall, The Four Courts, Royal College of Surgeons and Moore Street.
The centenary of the Easter Rising, the rebellion that began on Easter Monday 1916, is to be marked in Irish towns and cities with wreath-laying events.