Neil Aspin's promotion-chasing hosts have not lost in nine National League matches while Adam Lockwood's side are unbeaten in five.
Guiseley went ahead on 15 minutes against the run of play when a throw-in found James Hurst who squared to Jake Lawlor to stroke into an empty net.
Gateshead defender Liam Hogan superbly blocked Jordan Preston's effort and Guiseley keeper Jonny Maxted then saved well from Wesley York's shot just before the break.
The hosts, who started the second half well, levelled on 62 minutes when a slip by half-time substitute Derek Asamoah let York curl sweetly into the top-right corner from the edge of the box.
Match report supplied by the Press Association.
Match ends, Gateshead 1, Guiseley 1.
Second Half ends, Gateshead 1, Guiseley 1.
Substitution, Guiseley. Michael Rankine replaces Jordan Preston.
Substitution, Gateshead. Luke Hannant replaces Gus Mafuta.
Gus Mafuta (Gateshead) is shown the yellow card.
Substitution, Guiseley. Adam Boyes replaces Jake Cassidy.
Goal!  Gateshead 1, Guiseley 1. Wes York (Gateshead).
Substitution, Guiseley. Derek Asamoah replaces Kevan Hurst.
Second Half begins Gateshead 0, Guiseley 1.
First Half ends, Gateshead 0, Guiseley 1.
Simon Walton (Guiseley) is shown the yellow card.
Goal!  Gateshead 0, Guiseley 1. Jake Lawlor (Guiseley).
First Half begins.
Lineups are announced and players are warming up.
Gateshead and Guiseley extended their unbeaten runs with a 1-1 draw at the Gateshead International Stadium.