The event takes place at East Kirkcarswell Farm near Dundrennan on 25 and 26 July.
Dizzee Rascal will headline the opening night in his only Scottish festival appearance of the year.
Organisers have also unveiled a string of other acts including Martha Reeves and The Vandellas, The Zombies, Big Country and The Feeling.
Wickerman Festival co-ordinator Helen Chalmers said she was "thrilled" to be revealing the first acts.
"We are delighted that Dizzee Rascal will be joining the party this year, his live performances are incredible and I can't wait to see the crowd's reaction to his headline set," she said.
"From hip hop, pop, folk to Motown and alternative rock, this year's line-up will once again be a truly diverse offering.
"We look forward to announcing further exciting additions including our Saturday night headliner over the coming weeks."
Rapper Dizzee Rascal has been announced as one of the headline acts at this year's Wickerman Festival.