The teenager was taken to Southmead hospital with knife wounds, but died of his injuries.
Two 19-year-old men have been arrested on suspicion of murder following the stabbing on Stothard Road, Lockleaze, at about 5:50 GMT.
Avon and Somerset Police said the men remained in custody and the force is not looking for anyone else.
Officers have closed the road during investigations.
A 16-year-old boy has died after being stabbed during the early hours in Bristol.