The Latics are seven points from safety with six games remaining including tough trips to Brighton and Reading.
David McGoldrick put Ipswich ahead midway through the first half, slotting in Myles Kenlock's pass, before Freddie Sears raced clear to double the lead.
Wigan improved after the break, Bartosz Bialkowski saving brilliantly from Ryan Colclough and Alex Gilbey, but Sears pounced late on to make it 3-0.
The win relieved some of the pressure on Town boss Mick McCarthy, following seven draws in their last eight matches, and they are now nine points clear of the relegation zone.
A lack of goals has been one of the Tractor Boys' main issues this campaign, with only Wigan and Rotherham scoring fewer, but striker McGoldrick ended a 15-game drought to set the ball rolling.
It was the Republic of Ireland international's first goal since netting the winner in the reverse fixture on 17 December.
Sears has also been struggling to score this campaign, but the former West Ham forward showed superb composure to fire past Matt Gilks for his fourth goal of the season.
His second had an air of fortune as Gilks saved his first effort, which then fell at his feet for an easy tap-in - but the game was already over at that point.
With an average of 49 points keeping teams in the second tier since three points were introduced for a win in the early 1980s, the Latics, on 34 points, may need to win five of their last six matches to avoid an immediate return to League One.
Ipswich manager Mick McCarthy: "I am delighted about the result and the performance and also a little bit relieved about the fact we got three points and other results went for us.
"I thought David McGoldrick and Freddie Sears epitomised our performance, but I am also not going to just sit here crowing about everything.
"At the start of the second half, it seemed we were conspiring to give them a goal and our fabulous goalkeeper made sure it wasn't 2-1 - though I think we deserved the 3-0 win."
Wigan interim manager Graham Barrow: "The scoreline was fair as we gave them all three goals - but for Matt Gilks in goal, it could have been much worse.
"I am not even going to pretend that was okay. It was suicidal stuff, real kamikaze football and I do personally feel let down.
"Things were said in the dressing room, but they will stay in the dressing room, but the club, supporters and staff don't deserve that kind of performance. Our defending has actually been quite sound this season but all of a sudden that went up in smoke."
Match ends, Ipswich Town 3, Wigan Athletic 0.
Second Half ends, Ipswich Town 3, Wigan Athletic 0.
Attempt missed. Gabriel Obertan (Wigan Athletic) right footed shot from outside the box misses to the left.
Substitution, Ipswich Town. Dominic Samuel replaces David McGoldrick.
Foul by Dan Burn (Wigan Athletic).
David McGoldrick (Ipswich Town) wins a free kick on the right wing.
Corner,  Wigan Athletic. Conceded by Bartosz Bialkowski.
Attempt saved. Alex Gilbey (Wigan Athletic) right footed shot from outside the box is saved in the bottom right corner.
Attempt blocked. David McGoldrick (Ipswich Town) right footed shot from outside the box is blocked.
Attempt missed. Max Power (Wigan Athletic) right footed shot from outside the box is just a bit too high.
Goal!  Ipswich Town 3, Wigan Athletic 0. Freddie Sears (Ipswich Town) right footed shot from very close range to the bottom left corner.
Attempt saved. Freddie Sears (Ipswich Town) right footed shot from the centre of the box is saved in the bottom right corner. Assisted by Bartosz Bialkowski.
Attempt saved. Max Power (Wigan Athletic) header from the centre of the box is saved in the centre of the goal. Assisted by Alex Gilbey with a cross.
Corner,  Wigan Athletic. Conceded by Bartosz Bialkowski.
Attempt saved. Alex Gilbey (Wigan Athletic) right footed shot from outside the box is saved in the centre of the goal.
Attempt saved. Tommy Smith (Ipswich Town) header from the centre of the box is saved in the centre of the goal. Assisted by Grant Ward.
Max Power (Wigan Athletic) is shown the yellow card for a bad foul.
Christophe Berra (Ipswich Town) wins a free kick in the attacking half.
Foul by Max Power (Wigan Athletic).
Substitution, Wigan Athletic. Gabriel Obertan replaces Shaun MacDonald.
Substitution, Ipswich Town. Kevin Bru replaces Emyr Huws.
Attempt saved. David McGoldrick (Ipswich Town) right footed shot from outside the box is saved in the centre of the goal.
Substitution, Wigan Athletic. Callum Connolly replaces Stephen Warnock.
Toumani Diagouraga (Ipswich Town) wins a free kick on the left wing.
Foul by Max Power (Wigan Athletic).
Grant Ward (Ipswich Town) is shown the yellow card for a bad foul.
Foul by Grant Ward (Ipswich Town).
Jake Buxton (Wigan Athletic) wins a free kick in the defensive half.
Attempt saved. Grant Ward (Ipswich Town) right footed shot from the centre of the box is saved in the bottom left corner.
Attempt saved. Freddie Sears (Ipswich Town) right footed shot from the right side of the six yard box is saved in the centre of the goal. Assisted by Grant Ward.
Grant Ward (Ipswich Town) wins a free kick in the defensive half.
Foul by Michael Jacobs (Wigan Athletic).
Foul by Myles Kenlock (Ipswich Town).
Michael Jacobs (Wigan Athletic) wins a free kick on the right wing.
Attempt blocked. Max Power (Wigan Athletic) right footed shot from outside the box is blocked.
Corner,  Wigan Athletic. Conceded by Myles Kenlock.
Corner,  Wigan Athletic. Conceded by Bartosz Bialkowski.
Attempt saved. Michael Jacobs (Wigan Athletic) left footed shot from outside the box is saved in the centre of the goal.
Toumani Diagouraga (Ipswich Town) is shown the yellow card for a bad foul.
Max Power (Wigan Athletic) wins a free kick in the attacking half.
Wigan's Championship relegation worries deepened with defeat at Ipswich.