The giant striker was in the right place at the right time to bundle home the loose ball, after Morecambe's defence failed to clear, earning what could be an important draw.
They dropped to 11th, but remain just a point behind Blackpool in the final play-off spot and within two points of sixth-placed Carlisle.
Gareth Ainsworth's side had fallen behind eight minutes earlier when Morecambe veteran Kevin Ellison scored a superb opener.
Ellison received the ball with his back to goal on the edge of the area but turned quickly and curled a delightful effort past Jamal Blackman from the edge of the box.
The first half saw no goals, but plenty of endeavour from both sides.
Blackman was the busier of the two keepers making three excellent saves from three different players.
His best was a flying effort to tip away Michael Rose's 30-yard drive which was heading for the top right-hand corner of the Wycombe goal
The on-loan Chelsea goalkeeper then did well to tip over Paul Mullin's drive and a low volley from Ellison that was destined for the bottom left-hand corner.
Match report supplied by the Press Association
Match ends, Morecambe 1, Wycombe Wanderers 1.
Second Half ends, Morecambe 1, Wycombe Wanderers 1.
Attempt missed. Kevin Ellison (Morecambe) right footed shot from more than 35 yards misses to the left.
Corner,  Wycombe Wanderers. Conceded by Ryan Edwards.
Dean Winnard (Morecambe) wins a free kick in the defensive half.
Foul by Myles Weston (Wycombe Wanderers).
Goal!  Morecambe 1, Wycombe Wanderers 1. Adebayo Akinfenwa (Wycombe Wanderers) right footed shot from the centre of the box to the centre of the goal.
Attempt saved. Luke O'Nien (Wycombe Wanderers) header from the centre of the box is saved in the bottom right corner.
Attempt missed. Aaron Pierre (Wycombe Wanderers) right footed shot from outside the box is just a bit too high.
Corner,  Wycombe Wanderers. Conceded by Danijel Nizic.
Attempt saved. Adebayo Akinfenwa (Wycombe Wanderers) left footed shot from the centre of the box is saved in the top left corner.
Substitution, Morecambe. Liam Wakefield replaces Aaron McGowan.
Substitution, Wycombe Wanderers. Myles Weston replaces Garry Thompson because of an injury.
Goal!  Morecambe 1, Wycombe Wanderers 0. Kevin Ellison (Morecambe) left footed shot from outside the box to the bottom left corner. Assisted by Aaron McGowan.
Substitution, Morecambe. Steven Yawson replaces Paul Mullin.
Paris Cowan-Hall (Wycombe Wanderers) hits the bar with a header from the centre of the box.
Attempt blocked. Marcus Bean (Wycombe Wanderers) right footed shot from outside the box is blocked.
Foul by Alex Whitmore (Morecambe).
Adebayo Akinfenwa (Wycombe Wanderers) wins a free kick in the defensive half.
Aaron Pierre (Wycombe Wanderers) is shown the yellow card.
Kevin Ellison (Morecambe) is shown the yellow card.
Corner,  Morecambe. Conceded by Michael Harriman.
Peter Murphy (Morecambe) wins a free kick in the defensive half.
Foul by Luke O'Nien (Wycombe Wanderers).
Foul by Paul Mullin (Morecambe).
Sido Jombati (Wycombe Wanderers) wins a free kick on the right wing.
Substitution, Wycombe Wanderers. Anthony Stewart replaces Joe Jacobson because of an injury.
Substitution, Wycombe Wanderers. Paris Cowan-Hall replaces Paul Hayes.
Aaron McGowan (Morecambe) is shown the yellow card for a bad foul.
Foul by Aaron McGowan (Morecambe).
Joe Jacobson (Wycombe Wanderers) wins a free kick in the defensive half.
Attempt missed. Luke O'Nien (Wycombe Wanderers) right footed shot from outside the box is close, but misses to the right.
Substitution, Morecambe. Andrew Fleming replaces Peter Murphy because of an injury.
Attempt missed. Paul Hayes (Wycombe Wanderers) right footed shot from the right side of the box is close, but misses the top left corner.
Foul by Kevin Ellison (Morecambe).
Joe Jacobson (Wycombe Wanderers) wins a free kick on the left wing.
Attempt blocked. Lee Molyneux (Morecambe) left footed shot from outside the box is blocked.
Paul Mullin (Morecambe) wins a free kick in the defensive half.
Foul by Aaron Pierre (Wycombe Wanderers).
Joe Jacobson (Wycombe Wanderers) wins a free kick on the right wing.
Adebayo Akinfenwa's last-gasp equaliser kept Wycombe's quest for a League Two play-off spot alive at Morecambe.