NbCuC8N4H8OF5(C2NH2)2 crystallizes in the orthorhombic Cccm space group. The structure consists of eight n-methyl methanimine molecules and four pyrazine molecules inside a NbCuC8N4H8OF5 framework. In the NbCuC8N4H8OF5 framework, Nb(1) is bonded to one O(1), one F(3), two equivalent F(1), and two equivalent F(2) atoms to form NbOF5 octahedra that share  a cornercorner with one Cu(1)N4F2 octahedra and  a cornercorner with one Cu(2)N4O2 octahedra. The corner-sharing octahedra are not tilted. The Nb(1)-O(1) bond length is 1.80 Å. The Nb(1)-F(3) bond length is 2.08 Å. Both Nb(1)-F(1) bond lengths are 1.95 Å. Both Nb(1)-F(2) bond lengths are 1.94 Å. There are two inequivalent Cu sites. In the first Cu site, Cu(1) is bonded to two equivalent N(1), two equivalent N(3), and two equivalent F(3) atoms to form CuN4F2 octahedra that share corners with two equivalent Nb(1)OF5 octahedra. The corner-sharing octahedra are not tilted. Both Cu(1)-N(1) bond lengths are 2.05 Å. Both Cu(1)-N(3) bond lengths are 2.07 Å. Both Cu(1)-F(3) bond lengths are 2.26 Å. In the second Cu site, Cu(2) is bonded to two equivalent N(2), two equivalent N(4), and two equivalent O(1) atoms to form distorted CuN4O2 octahedra that share corners with two equivalent Nb(1)OF5 octahedra. The corner-sharing octahedra are not tilted. Both Cu(2)-N(2) bond lengths are 2.55 Å. Both Cu(2)-N(4) bond lengths are 2.07 Å. Both Cu(2)-O(1) bond lengths are 1.91 Å. There are four inequivalent C sites. In the first C site, C(3) is bonded in a distorted bent 120 degrees geometry to one N(3) and one H(3) atom. The C(3)-N(3) bond length is 1.34 Å. The C(3)-H(3) bond length is 1.09 Å. In the second C site, C(4) is bonded in a distorted trigonal planar geometry to one C(4), one N(4), and one H(4) atom. The C(4)-C(4) bond length is 1.39 Å. The C(4)-N(4) bond length is 1.34 Å. The C(4)-H(4) bond length is 1.09 Å. In the third C site, C(1) is bonded in a distorted trigonal planar geometry to one C(2), one N(1), and one H(1) atom. The C(1)-C(2) bond length is 1.40 Å. The C(1)-N(1) bond length is 1.35 Å. The C(1)-H(1) bond length is 1.09 Å. In the fourth C site, C(2) is bonded in a distorted trigonal planar geometry to one C(1), one N(2), and one H(2) atom. The C(2)-N(2) bond length is 1.34 Å. The C(2)-H(2) bond length is 1.09 Å. There are four inequivalent N sites. In the first N site, N(1) is bonded in a trigonal planar geometry to one Cu(1) and two equivalent C(1) atoms. In the second N site, N(2) is bonded in a distorted trigonal planar geometry to one Cu(2) and two equivalent C(2) atoms. In the third N site, N(3) is bonded in a trigonal planar geometry to one Cu(1) and two equivalent C(3) atoms. In the fourth N site, N(4) is bonded in a trigonal planar geometry to one Cu(2) and two equivalent C(4) atoms. There are four inequivalent H sites. In the first H site, H(1) is bonded in a single-bond geometry to one C(1) atom. In the second H site, H(2) is bonded in a single-bond geometry to one C(2) atom. In the third H site, H(3) is bonded in a single-bond geometry to one C(3) atom. In the fourth H site, H(4) is bonded in a single-bond geometry to one C(4) atom. There are two inequivalent O sites. In the first O site, O(1) is bonded in a linear geometry to one Nb(1) and one Cu(2) atom. In the second O site, O(1) is bonded in a linear geometry to one Nb(1) and one Cu(2) atom. The O(1)-Nb(1) bond length is 1.80 Å. The O(1)-Cu(2) bond length is 1.91 Å. There are four inequivalent F sites. In the first F site, F(1) is bonded in a single-bond geometry to one Nb(1) atom. In the second F site, F(2) is bonded in a single-bond geometry to one Nb(1) atom. In the third F site, F(3) is bonded in a linear geometry to one Nb(1) and one Cu(1) atom. In the fourth F site, F(3) is bonded in a linear geometry to one Nb(1) and one Cu(1) atom. The F(3)-Nb(1) bond length is 2.08 Å. The F(3)-Cu(1) bond length is 2.26 Å. Linkers: 2 c1cnccn1. Metal clusters: 4 [Nb] ,4 [Cu]. The MOF has largest included sphere 2.54 A, density 2.05 g/cm3, surface area 3511.97 m2/g, accessible volume 0.07 cm3/g