Ni2C10N4H8O5Cl2H2O crystallizes in the monoclinic Pc space group. The structure consists of two water molecules inside a Ni2C10N4H8O5Cl2 framework. In the Ni2C10N4H8O5Cl2 framework, there are two inequivalent Ni sites. In the first Ni site, Ni(1) is bonded in a distorted trigonal bipyramidal geometry to one N(1), one N(3), one O(1), one O(4), and one Cl(1) atom. The Ni(1)-N(1) bond length is 1.89 Å. The Ni(1)-N(3) bond length is 1.90 Å. The Ni(1)-O(1) bond length is 1.93 Å. The Ni(1)-O(4) bond length is 1.95 Å. The Ni(1)-Cl(1) bond length is 2.52 Å. In the second Ni site, Ni(2) is bonded in an octahedral geometry to one N(2), one N(4), one O(2), one O(3), one O(6), and one Cl(2) atom. The Ni(2)-N(2) bond length is 2.01 Å. The Ni(2)-N(4) bond length is 2.01 Å. The Ni(2)-O(2) bond length is 2.05 Å. The Ni(2)-O(3) bond length is 2.05 Å. The Ni(2)-O(6) bond length is 2.27 Å. The Ni(2)-Cl(2) bond length is 2.36 Å. There are ten inequivalent C sites. In the first C site, C(1) is bonded in a distorted bent 120 degrees geometry to one C(3), one O(1), and one O(3) atom. The C(1)-C(3) bond length is 1.48 Å. The C(1)-O(1) bond length is 1.28 Å. The C(1)-O(3) bond length is 1.26 Å. In the second C site, C(2) is bonded in a distorted bent 120 degrees geometry to one C(4), one O(2), and one O(4) atom. The C(2)-C(4) bond length is 1.50 Å. The C(2)-O(2) bond length is 1.26 Å. The C(2)-O(4) bond length is 1.28 Å. In the third C site, C(3) is bonded in a distorted single-bond geometry to one C(1), one C(5), and one N(1) atom. The C(3)-C(5) bond length is 1.38 Å. The C(3)-N(1) bond length is 1.36 Å. In the fourth C site, C(4) is bonded in a distorted single-bond geometry to one C(2), one C(6), and one N(2) atom. The C(4)-C(6) bond length is 1.39 Å. The C(4)-N(2) bond length is 1.35 Å. In the fifth C site, C(5) is bonded in a distorted bent 120 degrees geometry to one C(3), one N(3), and one H(1) atom. The C(5)-N(3) bond length is 1.35 Å. The C(5)-H(1) bond length is 1.09 Å. In the sixth C site, C(6) is bonded in a distorted bent 120 degrees geometry to one C(4), one N(4), and one H(2) atom. The C(6)-N(4) bond length is 1.35 Å. The C(6)-H(2) bond length is 1.09 Å. In the seventh C site, C(7) is bonded in a distorted trigonal planar geometry to one C(9), one N(3), and one H(3) atom. The C(7)-C(9) bond length is 1.39 Å. The C(7)-N(3) bond length is 1.34 Å. The C(7)-H(3) bond length is 1.09 Å. In the eighth C site, C(8) is bonded in a distorted trigonal planar geometry to one C(10), one N(4), and one H(4) atom. The C(8)-C(10) bond length is 1.39 Å. The C(8)-N(4) bond length is 1.34 Å. The C(8)-H(4) bond length is 1.09 Å. In the ninth C site, C(9) is bonded in a distorted trigonal planar geometry to one C(7), one N(1), and one H(5) atom. The C(9)-N(1) bond length is 1.34 Å. The C(9)-H(5) bond length is 1.08 Å. In the tenth C site, C(10) is bonded in a distorted trigonal planar geometry to one C(8), one N(2), and one H(6) atom. The C(10)-N(2) bond length is 1.34 Å. The C(10)-H(6) bond length is 1.09 Å. There are four inequivalent N sites. In the first N site, N(1) is bonded in a trigonal planar geometry to one Ni(1), one C(3), and one C(9) atom. In the second N site, N(2) is bonded in a trigonal planar geometry to one Ni(2), one C(10), and one C(4) atom. In the third N site, N(3) is bonded in a trigonal planar geometry to one Ni(1), one C(5), and one C(7) atom. In the fourth N site, N(4) is bonded in a trigonal planar geometry to one Ni(2), one C(6), and one C(8) atom. There are eight inequivalent H sites. In the first H site, H(1) is bonded in a single-bond geometry to one C(5) atom. In the second H site, H(2) is bonded in a single-bond geometry to one C(6) atom. In the third H site, H(3) is bonded in a single-bond geometry to one C(7) atom. In the fourth H site, H(4) is bonded in a single-bond geometry to one C(8) atom. In the fifth H site, H(5) is bonded in a single-bond geometry to one C(9) atom. In the sixth H site, H(6) is bonded in a single-bond geometry to one C(10) atom. In the seventh H site, H(8) is bonded in a single-bond geometry to one O(6) atom. The H(8)-O(6) bond length is 1.00 Å. In the eighth H site, H(10) is bonded in a single-bond geometry to one O(6) atom. The H(10)-O(6) bond length is 0.97 Å. There are five inequivalent O sites. In the first O site, O(1) is bonded in a bent 120 degrees geometry to one Ni(1) and one C(1) atom. In the second O site, O(2) is bonded in a bent 120 degrees geometry to one Ni(2) and one C(2) atom. In the third O site, O(3) is bonded in a distorted bent 120 degrees geometry to one Ni(2) and one C(1) atom. In the fourth O site, O(4) is bonded in a bent 120 degrees geometry to one Ni(1) and one C(2) atom. In the fifth O site, O(6) is bonded in a distorted water-like geometry to one Ni(2), one H(10), and one H(8) atom. There are two inequivalent Cl sites. In the first Cl site, Cl(1) is bonded in a single-bond geometry to one Ni(1) atom. In the second Cl site, Cl(2) is bonded in a single-bond geometry to one Ni(2) atom. Linkers: 2 [O]C(=O)c1cnccn1. Metal clusters: 4 [Ni]. The MOF has largest included sphere 2.59 A, density 1.95 g/cm3, surface area 3682.90 m2/g, accessible volume 0.14 cm3/g