AgC5NH6O2CF2 crystallizes in the trigonal R-3c space group. The structure consists of seventy-two difluoromethane molecules inside a AgC5NH6O2 framework. In the AgC5NH6O2 framework, there are three inequivalent Ag sites. In the first Ag site, Ag(1) is bonded in a 3-coordinate geometry to one N(1) and two equivalent O(2) atoms. The Ag(1)-N(1) bond length is 2.21 Å. Both Ag(1)-O(2) bond lengths are 2.32 Å. In the second Ag site, Ag(2) is bonded in a 4-coordinate geometry to one N(2), one O(1), one O(3), and one O(4) atom. The Ag(2)-N(2) bond length is 2.20 Å. The Ag(2)-O(1) bond length is 2.27 Å. The Ag(2)-O(3) bond length is 2.76 Å. The Ag(2)-O(4) bond length is 2.35 Å. In the third Ag site, Ag(3) is bonded in a distorted trigonal planar geometry to one N(3) and two equivalent O(3) atoms. The Ag(3)-N(3) bond length is 2.22 Å. Both Ag(3)-O(3) bond lengths are 2.33 Å. There are ten inequivalent C sites. In the first C site, C(3) is bonded in a distorted bent 120 degrees geometry to one O(1) and one O(2) atom. The C(3)-O(1) bond length is 1.26 Å. The C(3)-O(2) bond length is 1.26 Å. In the second C site, C(4) is bonded in a distorted trigonal non-coplanar geometry to one C(7), one H(1), one H(2), and one H(3) atom. The C(4)-C(7) bond length is 1.49 Å. The C(4)-H(1) bond length is 1.10 Å. The C(4)-H(2) bond length is 1.10 Å. The C(4)-H(3) bond length is 1.10 Å. In the third C site, C(5) is bonded in a distorted trigonal non-coplanar geometry to one C(8), one H(4), one H(5), and one H(6) atom. The C(5)-C(8) bond length is 1.49 Å. The C(5)-H(4) bond length is 1.10 Å. The C(5)-H(5) bond length is 1.10 Å. The C(5)-H(6) bond length is 1.10 Å. In the fourth C site, C(6) is bonded in a distorted bent 120 degrees geometry to one O(3) and one O(4) atom. The C(6)-O(3) bond length is 1.26 Å. The C(6)-O(4) bond length is 1.26 Å. In the fifth C site, C(7) is bonded in a distorted trigonal planar geometry to one C(11), one C(4), and one N(1) atom. The C(7)-C(11) bond length is 1.41 Å. The C(7)-N(1) bond length is 1.35 Å. In the sixth C site, C(8) is bonded in a distorted trigonal planar geometry to one C(5), one C(9), and one N(2) atom. The C(8)-C(9) bond length is 1.41 Å. The C(8)-N(2) bond length is 1.35 Å. In the seventh C site, C(9) is bonded in a distorted trigonal planar geometry to one C(10), one C(8), and one N(2) atom. The C(9)-C(10) bond length is 1.49 Å. The C(9)-N(2) bond length is 1.35 Å. In the eighth C site, C(10) is bonded in a distorted trigonal non-coplanar geometry to one C(9), one H(7), one H(8), and one H(9) atom. The C(10)-H(7) bond length is 1.10 Å. The C(10)-H(8) bond length is 1.10 Å. The C(10)-H(9) bond length is 1.10 Å. In the ninth C site, C(11) is bonded in a distorted trigonal planar geometry to one C(12), one C(7), and one N(3) atom. The C(11)-C(12) bond length is 1.50 Å. The C(11)-N(3) bond length is 1.34 Å. In the tenth C site, C(12) is bonded in a distorted trigonal non-coplanar geometry to one C(11), one H(10), one H(11), and one H(12) atom. The C(12)-H(10) bond length is 1.10 Å. The C(12)-H(11) bond length is 1.10 Å. The C(12)-H(12) bond length is 1.10 Å. There are three inequivalent N sites. In the first N site, N(1) is bonded in a trigonal planar geometry to one Ag(1) and two equivalent C(7) atoms. In the second N site, N(2) is bonded in a trigonal planar geometry to one Ag(2), one C(8), and one C(9) atom. In the third N site, N(3) is bonded in a trigonal planar geometry to one Ag(3) and two equivalent C(11) atoms. There are twelve inequivalent H sites. In the first H site, H(6) is bonded in a single-bond geometry to one C(5) atom. In the second H site, H(7) is bonded in a single-bond geometry to one C(10) atom. In the third H site, H(8) is bonded in a single-bond geometry to one C(10) atom. In the fourth H site, H(9) is bonded in a single-bond geometry to one C(10) atom. In the fifth H site, H(10) is bonded in a single-bond geometry to one C(12) atom. In the sixth H site, H(11) is bonded in a single-bond geometry to one C(12) atom. In the seventh H site, H(1) is bonded in a single-bond geometry to one C(4) atom. In the eighth H site, H(12) is bonded in a single-bond geometry to one C(12) atom. In the ninth H site, H(2) is bonded in a single-bond geometry to one C(4) atom. In the tenth H site, H(3) is bonded in a single-bond geometry to one C(4) atom. In the eleventh H site, H(4) is bonded in a single-bond geometry to one C(5) atom. In the twelfth H site, H(5) is bonded in a single-bond geometry to one C(5) atom. There are four inequivalent O sites. In the first O site, O(3) is bonded in a 1-coordinate geometry to one Ag(2), one Ag(3), and one C(6) atom. In the second O site, O(2) is bonded in a distorted bent 120 degrees geometry to one Ag(1) and one C(3) atom. In the third O site, O(4) is bonded in a distorted single-bond geometry to one Ag(2) and one C(6) atom. In the fourth O site, O(1) is bonded in a distorted bent 120 degrees geometry to one Ag(2) and one C(3) atom. Linkers: 12 Cc1nc(C)c(C)nc1C ,12 [O]C(=O)C(F)(F)C(F)(F)C([O])=O. Metal clusters: 24 [Ag]. The MOF has largest included sphere 6.85 A, density 1.78 g/cm3, surface area 3112.84 m2/g, accessible volume 0.27 cm3/g