CuC6N4H3O2F crystallizes in the orthorhombic P2_12_12_1 space group. Cu(1) is bonded to one N(1), two equivalent N(2), one O(1), and one O(2) atom to form corner-sharing CuN3O2 trigonal bipyramids. The Cu(1)-N(1) bond length is 2.16 Å. There is one shorter (2.01 Å) and one longer (2.06 Å) Cu(1)-N(2) bond length. The Cu(1)-O(1) bond length is 2.00 Å. The Cu(1)-O(2) bond length is 1.98 Å. There are six inequivalent C sites. In the first C site, C(5) is bonded in a distorted single-bond geometry to one C(4), one C(6), and one F(1) atom. The C(5)-C(4) bond length is 1.38 Å. The C(5)-C(6) bond length is 1.39 Å. The C(5)-F(1) bond length is 1.35 Å. In the second C site, C(6) is bonded in a distorted trigonal planar geometry to one C(5), one N(1), and one H(3) atom. The C(6)-N(1) bond length is 1.34 Å. The C(6)-H(3) bond length is 1.09 Å. In the third C site, C(1) is bonded in a distorted bent 120 degrees geometry to one C(2), one O(1), and one O(2) atom. The C(1)-C(2) bond length is 1.50 Å. The C(1)-O(1) bond length is 1.27 Å. The C(1)-O(2) bond length is 1.28 Å. In the fourth C site, C(2) is bonded in a trigonal planar geometry to one C(1), one C(3), and one C(4) atom. The C(2)-C(3) bond length is 1.40 Å. The C(2)-C(4) bond length is 1.40 Å. In the fifth C site, C(3) is bonded in a distorted trigonal planar geometry to one C(2), one N(1), and one H(1) atom. The C(3)-N(1) bond length is 1.35 Å. The C(3)-H(1) bond length is 1.09 Å. In the sixth C site, C(4) is bonded in a distorted trigonal planar geometry to one C(2), one C(5), and one H(2) atom. The C(4)-H(2) bond length is 1.09 Å. There are four inequivalent N sites. In the first N site, N(1) is bonded in a trigonal planar geometry to one Cu(1), one C(3), and one C(6) atom. In the second N site, N(2) is bonded in a distorted trigonal planar geometry to two equivalent Cu(1) and one N(3) atom. The N(2)-N(3) bond length is 1.21 Å. In the third N site, N(3) is bonded in a linear geometry to one N(2) and one N(4) atom. The N(3)-N(4) bond length is 1.16 Å. In the fourth N site, N(4) is bonded in a single-bond geometry to one N(3) atom. There are three inequivalent H sites. In the first H site, H(1) is bonded in a single-bond geometry to one C(3) atom. In the second H site, H(2) is bonded in a single-bond geometry to one C(4) atom. In the third H site, H(3) is bonded in a single-bond geometry to one C(6) atom. There are two inequivalent O sites. In the first O site, O(2) is bonded in a bent 120 degrees geometry to one Cu(1) and one C(1) atom. In the second O site, O(1) is bonded in a distorted bent 150 degrees geometry to one Cu(1) and one C(1) atom. F(1) is bonded in a single-bond geometry to one C(5) atom. Linkers: 4 [O]C(=O)c1cncc(F)c1. Metal clusters: 4 [Cu]. The MOF has largest included sphere 1.85 A, density 2.07 g/cm3, surface area 3525.69 m2/g, accessible volume 0.09 cm3/g