AgC8N4H6S2O5CF3 crystallizes in the orthorhombic Pna2_1 space group. The structure consists of four trifluoromethane molecules inside a AgC8N4H6S2O5 framework. In the AgC8N4H6S2O5 framework, Ag(1) is bonded in a 4-coordinate geometry to one N(1), one N(2), one N(3), and one O(3) atom. The Ag(1)-N(1) bond length is 2.37 Å. The Ag(1)-N(2) bond length is 2.41 Å. The Ag(1)-N(3) bond length is 2.35 Å. The Ag(1)-O(3) bond length is 2.47 Å. There are eight inequivalent C sites. In the first C site, C(1) is bonded in a distorted bent 120 degrees geometry to one C(2), one N(1), and one H(1) atom. The C(1)-C(2) bond length is 1.39 Å. The C(1)-N(1) bond length is 1.34 Å. The C(1)-H(1) bond length is 1.09 Å. In the second C site, C(2) is bonded in a distorted trigonal planar geometry to one C(1), one N(2), and one S(1) atom. The C(2)-N(2) bond length is 1.34 Å. The C(2)-S(1) bond length is 1.80 Å. In the third C site, C(3) is bonded in a distorted trigonal planar geometry to one C(4), one N(2), and one H(2) atom. The C(3)-C(4) bond length is 1.40 Å. The C(3)-N(2) bond length is 1.34 Å. The C(3)-H(2) bond length is 1.09 Å. In the fourth C site, C(4) is bonded in a distorted trigonal planar geometry to one C(3), one N(1), and one H(3) atom. The C(4)-N(1) bond length is 1.34 Å. The C(4)-H(3) bond length is 1.09 Å. In the fifth C site, C(5) is bonded in a distorted single-bond geometry to one C(6), one N(4), and one S(1) atom. The C(5)-C(6) bond length is 1.39 Å. The C(5)-N(4) bond length is 1.33 Å. The C(5)-S(1) bond length is 1.80 Å. In the sixth C site, C(6) is bonded in a distorted trigonal planar geometry to one C(5), one N(3), and one H(4) atom. The C(6)-N(3) bond length is 1.35 Å. The C(6)-H(4) bond length is 1.09 Å. In the seventh C site, C(7) is bonded in a distorted bent 120 degrees geometry to one N(3) and one H(5) atom. The C(7)-N(3) bond length is 1.34 Å. The C(7)-H(5) bond length is 1.09 Å. In the eighth C site, C(8) is bonded in a distorted bent 120 degrees geometry to one N(4) and one H(6) atom. The C(8)-N(4) bond length is 1.33 Å. The C(8)-H(6) bond length is 1.09 Å. There are four inequivalent N sites. In the first N site, N(1) is bonded in a distorted trigonal planar geometry to one Ag(1), one C(1), and one C(4) atom. In the second N site, N(2) is bonded in a distorted trigonal planar geometry to one Ag(1), one C(2), and one C(3) atom. In the third N site, N(3) is bonded in a trigonal planar geometry to one Ag(1), one C(6), and one C(7) atom. In the fourth N site, N(4) is bonded in a bent 120 degrees geometry to one C(5) and one C(8) atom. There are six inequivalent H sites. In the first H site, H(1) is bonded in a single-bond geometry to one C(1) atom. In the second H site, H(2) is bonded in a single-bond geometry to one C(3) atom. In the third H site, H(3) is bonded in a single-bond geometry to one C(4) atom. In the fourth H site, H(4) is bonded in a single-bond geometry to one C(6) atom. In the fifth H site, H(5) is bonded in a single-bond geometry to one C(7) atom. In the sixth H site, H(6) is bonded in a single-bond geometry to one C(8) atom. There are two inequivalent S sites. In the first S site, S(1) is bonded in a distorted bent 120 degrees geometry to one C(2), one C(5), one O(1), and one O(2) atom. The S(1)-O(1) bond length is 1.45 Å. The S(1)-O(2) bond length is 1.44 Å. In the second S site, S(2) is bonded in a distorted trigonal non-coplanar geometry to one O(3), one O(4), and one O(5) atom. The S(2)-O(3) bond length is 1.47 Å. The S(2)-O(4) bond length is 1.46 Å. The S(2)-O(5) bond length is 1.46 Å. There are five inequivalent O sites. In the first O site, O(1) is bonded in a single-bond geometry to one S(1) atom. In the second O site, O(2) is bonded in a single-bond geometry to one S(1) atom. In the third O site, O(3) is bonded in a distorted single-bond geometry to one Ag(1) and one S(2) atom. In the fourth O site, O(4) is bonded in a single-bond geometry to one S(2) atom. In the fifth O site, O(5) is bonded in a single-bond geometry to one S(2) atom. Linkers: 4 O=S(=O)(c1cnccn1)c1cnccn1. Metal clusters: 4 [O]S([O])(O[Ag])C(F)(F)F. The MOF has largest included sphere 1.73 A, density 2.26 g/cm3, surface area 3348.24 m2/g, accessible volume 0.07 cm3/g