Cu4C12N10H8O9(C3H2)8(C3NH4)4 is Indium-derived structured and crystallizes in the orthorhombic Fddd space group. The structure is zero-dimensional and consists of thirty-two 2,3-dimethyl-1,3-butadiene molecules; thirty-two trimethylamine molecules; and eight Cu4C12N10H8O9 clusters. In each Cu4C12N10H8O9 cluster, Cu(1) is bonded to one N(2), one N(3), one O(1), one O(2), and one O(3) atom to form a mixture of edge and corner-sharing CuN2O3 square pyramids. The Cu(1)-N(2) bond length is 2.01 Å. The Cu(1)-N(3) bond length is 1.98 Å. The Cu(1)-O(1) bond length is 1.95 Å. The Cu(1)-O(2) bond length is 2.24 Å. The Cu(1)-O(3) bond length is 1.94 Å. There are three inequivalent C sites. In the first C site, C(1) is bonded in a distorted bent 120 degrees geometry to one O(1) and one O(2) atom. The C(1)-O(1) bond length is 1.25 Å. The C(1)-O(2) bond length is 1.24 Å. In the second C site, C(11) is bonded in a distorted bent 120 degrees geometry to one N(2) and one H(9) atom. The C(11)-N(2) bond length is 1.34 Å. The C(11)-H(9) bond length is 0.93 Å. In the third C site, C(12) is bonded in a distorted bent 120 degrees geometry to one N(2) and one H(10) atom. The C(12)-N(2) bond length is 1.34 Å. The C(12)-H(10) bond length is 0.93 Å. There are four inequivalent N sites. In the first N site, N(2) is bonded in a trigonal planar geometry to one Cu(1), one C(11), and one C(12) atom. In the second N site, N(3) is bonded in a distorted trigonal planar geometry to two equivalent Cu(1) and one N(4) atom. The N(3)-N(4) bond length is 1.18 Å. In the third N site, N(4) is bonded in a linear geometry to one N(3) and one N(5) atom. The N(4)-N(5) bond length is 1.14 Å. In the fourth N site, N(5) is bonded in a single-bond geometry to one N(4) atom. There are two inequivalent H sites. In the first H site, H(9) is bonded in a single-bond geometry to one C(11) atom. In the second H site, H(10) is bonded in a single-bond geometry to one C(12) atom. There are three inequivalent O sites. In the first O site, O(3) is bonded in a tetrahedral geometry to four equivalent Cu(1) atoms. In the second O site, O(1) is bonded in a distorted bent 120 degrees geometry to one Cu(1) and one C(1) atom. In the third O site, O(2) is bonded in a bent 120 degrees geometry to one Cu(1) and one C(1) atom. Linkers: 32 [O]C(=O)CN1[CH]C=C(c2ccncc2)C=C1. Metal clusters: 32 [Cu]. The MOF has largest included sphere 4.76 A, density 1.34 g/cm3, surface area 4228.35 m2/g, accessible volume 0.32 cm3/g