Ag4C8N2H3O2F3 crystallizes in the orthorhombic Pbca space group. There are four inequivalent Ag sites. In the first Ag site, Ag(1) is bonded in a bent 150 degrees geometry to one C(1) and one O(2) atom. The Ag(1)-C(1) bond length is 2.20 Å. The Ag(1)-O(2) bond length is 2.35 Å. In the second Ag site, Ag(2) is bonded in a linear geometry to one C(1) and one N(1) atom. The Ag(2)-C(1) bond length is 2.35 Å. The Ag(2)-N(1) bond length is 2.38 Å. In the third Ag site, Ag(3) is bonded in a 3-coordinate geometry to one C(1), one N(2), and one O(1) atom. The Ag(3)-C(1) bond length is 2.23 Å. The Ag(3)-N(2) bond length is 2.32 Å. The Ag(3)-O(1) bond length is 2.60 Å. In the fourth Ag site, Ag(4) is bonded in a 3-coordinate geometry to one C(1), one C(2), and one O(2) atom. The Ag(4)-C(1) bond length is 2.50 Å. The Ag(4)-C(2) bond length is 2.53 Å. The Ag(4)-O(2) bond length is 2.41 Å. There are eight inequivalent C sites. In the first C site, C(1) is bonded in a 5-coordinate geometry to one Ag(1), one Ag(2), one Ag(3), one Ag(4), and one C(2) atom. The C(1)-C(2) bond length is 1.22 Å. In the second C site, C(2) is bonded in a distorted trigonal non-coplanar geometry to one Ag(4), one C(1), and one C(3) atom. The C(2)-C(3) bond length is 1.45 Å. In the third C site, C(3) is bonded in a trigonal planar geometry to one C(2), one C(4), and one C(6) atom. The C(3)-C(4) bond length is 1.40 Å. The C(3)-C(6) bond length is 1.39 Å. In the fourth C site, C(4) is bonded in a distorted bent 120 degrees geometry to one C(3), one N(1), and one H(1) atom. The C(4)-N(1) bond length is 1.33 Å. The C(4)-H(1) bond length is 0.93 Å. In the fifth C site, C(5) is bonded in a trigonal planar geometry to one N(1), one N(2), and one H(2) atom. The C(5)-N(1) bond length is 1.34 Å. The C(5)-N(2) bond length is 1.34 Å. The C(5)-H(2) bond length is 0.93 Å. In the sixth C site, C(6) is bonded in a distorted bent 120 degrees geometry to one C(3), one N(2), and one H(3) atom. The C(6)-N(2) bond length is 1.34 Å. The C(6)-H(3) bond length is 0.93 Å. In the seventh C site, C(7) is bonded in a distorted trigonal planar geometry to one C(8), one O(1), and one O(2) atom. The C(7)-C(8) bond length is 1.52 Å. The C(7)-O(1) bond length is 1.22 Å. The C(7)-O(2) bond length is 1.23 Å. In the eighth C site, C(8) is bonded in a 3-coordinate geometry to one C(7), one F(1), one F(2), and one F(3) atom. The C(8)-F(1) bond length is 1.37 Å. The C(8)-F(2) bond length is 1.25 Å. The C(8)-F(3) bond length is 1.30 Å. There are two inequivalent N sites. In the first N site, N(1) is bonded in a distorted trigonal planar geometry to one Ag(2), one C(4), and one C(5) atom. In the second N site, N(2) is bonded in a trigonal planar geometry to one Ag(3), one C(5), and one C(6) atom. There are three inequivalent H sites. In the first H site, H(1) is bonded in a single-bond geometry to one C(4) atom. In the second H site, H(2) is bonded in a single-bond geometry to one C(5) atom. In the third H site, H(3) is bonded in a single-bond geometry to one C(6) atom. There are two inequivalent O sites. In the first O site, O(1) is bonded in a distorted single-bond geometry to one Ag(3) and one C(7) atom. In the second O site, O(2) is bonded in a 3-coordinate geometry to one Ag(1), one Ag(4), and one C(7) atom. There are three inequivalent F sites. In the first F site, F(1) is bonded in a single-bond geometry to one C(8) atom. In the second F site, F(2) is bonded in a single-bond geometry to one C(8) atom. In the third F site, F(3) is bonded in a single-bond geometry to one C(8) atom. Linkers: 8 [C]#Cc1cncnc1. Metal clusters: 32 [Ag]. The MOF has largest included sphere 5.30 A, density 2.00 g/cm3, surface area 2338.43 m2/g, accessible volume 0.21 cm3/g