NiH16(C3O)8(C3H2O)4 is Indium-derived structured and crystallizes in the cubic Im-3m space group. The structure is zero-dimensional and consists of eight 1,2,3,4,5,6-hexakis(methoxymethyl)benzene molecules and twelve NiH16(C3O)8 clusters. In each NiH16(C3O)8 cluster, Ni(1) is bonded in a rectangular see-saw-like geometry to four equivalent O(2) atoms. All Ni(1)-O(2) bond lengths are 2.02 Å. There are six inequivalent C sites. In the first C site, C(1) is bonded in a distorted bent 120 degrees geometry to one C(2), one O(1), and one O(2) atom. The C(1)-C(2) bond length is 1.53 Å. The C(1)-O(1) bond length is 1.24 Å. The C(1)-O(2) bond length is 1.21 Å. In the second C site, C(2) is bonded in a trigonal planar geometry to one C(1), one C(3), and one C(7) atom. The C(2)-C(3) bond length is 1.31 Å. The C(2)-C(7) bond length is 1.41 Å. In the third C site, C(3) is bonded in a distorted single-bond geometry to one C(2), one C(4), and one H(2) atom. The C(3)-C(4) bond length is 1.23 Å. The C(3)-H(2) bond length is 0.93 Å. In the fourth C site, C(4) is bonded in a distorted trigonal planar geometry to one C(3), one C(5), and one H(3) atom. The C(4)-C(5) bond length is 1.43 Å. The C(4)-H(3) bond length is 0.93 Å. In the fifth C site, C(5) is bonded in a distorted single-bond geometry to one C(4) and one H(4) atom. The C(5)-H(4) bond length is 0.93 Å. In the sixth C site, C(7) is bonded in a distorted single-bond geometry to one C(2) and one H(5) atom. The C(7)-H(5) bond length is 0.93 Å. There are four inequivalent H sites. In the first H site, H(2) is bonded in a single-bond geometry to one C(3) atom. In the second H site, H(3) is bonded in a single-bond geometry to one C(4) atom. In the third H site, H(4) is bonded in a single-bond geometry to one C(5) atom. In the fourth H site, H(5) is bonded in a single-bond geometry to one C(7) atom. There are two inequivalent O sites. In the first O site, O(1) is bonded in a single-bond geometry to one C(1) atom. In the second O site, O(2) is bonded in a distorted bent 120 degrees geometry to one Ni(1) and one C(1) atom. Linkers: 8 [O]C(=O)c1cccc(OCc2c(COc3cccc(C([O])=O)c3)c(COc3cccc(C([O])=O)c3)c(COc3cccc(C([O])=O)c3)c(COc3cccc(C([O])=O)c3)c2COc2cccc(C([O])=O)c2)c1. Metal clusters: 12 O=[C]O[Ni](O[C]=O)(O[C]=O)O[C]=O. RCSR code: soc. The MOF has largest included sphere 16.39 A, density 0.52 g/cm3, surface area 5054.87 m2/g, accessible volume 1.44 cm3/g