[biological_process] GDF15-GFRAL signaling pathway <sep> negative regulation of appetite <sep> negative regulation of extrinsic apoptotic signaling pathway in absence of ligand <sep> negative regulation of neuron apoptotic process <sep> nervous system development <sep> positive regulation of MAPK cascade <sep> positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction <sep> reduction of food intake in response to dietary excess <sep> response to metformin <sep> stress-activated protein kinase signaling cascade