[biological_process] cellular response to chemical stress <sep> energy homeostasis <sep> GDF15-GFRAL signaling pathway <sep> negative regulation of appetite <sep> negative regulation of growth hormone receptor signaling pathway <sep> negative regulation of leukocyte migration <sep> negative regulation of multicellular organism growth <sep> negative regulation of SMAD protein signal transduction <sep> negative regulation of transforming growth factor beta receptor signaling pathway <sep> positive regulation of fatty acid oxidation <sep> positive regulation of MAPK cascade <sep> positive regulation of myoblast fusion <sep> positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction <sep> reduction of food intake in response to dietary excess <sep> response to metformin