[molecular_function] cullin family protein binding <sep> molecular adaptor activity <sep> NEDD8 ligase activity <sep> NEDD8 transferase activity <sep> RNA polymerase II-specific DNA-binding transcription factor binding <sep> ubiquitin protein ligase activity <sep> ubiquitin protein ligase binding <sep> ubiquitin-ubiquitin ligase activity <sep> zinc ion binding