[molecular_function] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity <sep> ATP binding <sep> flavonoid binding <sep> inositol tetrakisphosphate 3-kinase activity <sep> inositol tetrakisphosphate 5-kinase activity <sep> inositol tetrakisphosphate 6-kinase activity <sep> inositol tetrakisphosphate kinase activity <sep> inositol-1,4,5-trisphosphate 3-kinase activity <sep> inositol-1,4,5-trisphosphate 6-kinase activity <sep> metal ion binding <sep> myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity