anchor.diff:  # Install Python 3 packages
   RUN pip install \
       awscli==1.16.81 \
  -    beautifulsoup4==4.6 \
  -    biopython==1.70 \
  -    bokeh==0.12 \
  -    certifi \
  -    click \
  -    cloudpickle==0.2.2 \
  -    cython==0.26 \
  -    dill==0.2 \
  -    h5py==2.7.0 \
  -    ipywidgets==5.2.2 \
  +    # beautifulsoup4==4.6 \
  +    biopython==1.72 \
  +    bokeh==1.0.3 \
  +    certifi==2018.10.15 \
  +    click==7.0 \
  +    # cloudpickle==0.2.2 \
  +    cython==0.29.2 \
  +    # dill==0.2 \
  +    # h5py==2.9.0 \
  +    ipywidgets==7.4.2 \
       jupyterthemes==0.20.0 \
  -    jupyter_contrib_nbextensions==0.5.0 \
  -    pandas==0.20.3 \
  -    matplotlib==2.0.0 \
  -    numba==0.34.0 \
  -    numexpr==2.6.0 \
  -    patsy==0.4.0 \
  -# do we need skimage? it's rather large
  -#    scikit-image==0.13.0 \
  +    jupyter_contrib_nbextensions==0.5.1 \
  +    pandas==0.23.0 \
  +    matplotlib==3.0.2 \
  +    numba==0.42.0 \
  +    numexpr==2.6.9 \
  +    # patsy==0.4.0 \
  +    # scikit-image==0.13.0 \
       scikit-learn==0.19.0 \
  -    scipy==0.19.0 \
  -    seaborn==0.8 \
  +    scipy==1.1.0 \
  +    seaborn==0.9.0 \
       selenium==3.141.0 \
  -    sqlalchemy==1.1.0 \
  -    statsmodels==0.8.0 \
  -    sympy==1.1 \
  -    vincent==0.4.0 \
  -    weasyprint==0.42.3 \
  +    # sqlalchemy==1.1.0 \
  +    # statsmodels==0.8.0 \
  +    # sympy==1.1 \
  +    # vincent==0.4.0 \
  +    weasyprint==44 \
       xlrd==1.2.0
   
   # Jupyter notebook should have already been installed above, but here we force a particular version
  
positive.code: RUN echo "en_US.UTF-8 UTF-8" > /etc/locale.gen && \
      locale-gen
  
  # Install Tini
  RUN wget --quiet https://github.com/krallin/tini/releases/download/v0.9.0/tini && \
      echo "faafbfb5b079303691a939a747d7f60591f2143164093727e870b289a44d9872 *tini" | sha256sum -c - && \
      mv tini /usr/local/bin/tini && \
      chmod +x /usr/local/bin/tini
  
  # Configure environment
  ENV SHELL /bin/bash
  
negative.code: 
  FROM python:3.6.6-slim-stretch
  
  LABEL maintainer="Nick Greenfield <nick@onecodex.com>"
  
  USER root
  
  