anchor.diff:  RUN apt-key adv --keyserver keyserver.ubuntu.com --recv-keys E298A3A825C0D65DFD57CBB651716619E084DAB9
   RUN apt-get -yq update
   
  +ENV DEBIAN_FRONTEND "noninteractive" 
   # no benefit of combined in builder stage
   RUN apt-get install -yq --no-install-recommends locales
   RUN apt-get install -yq --no-install-recommends g++
  
positive.code: 
  LABEL maintainer="cgphelp@sanger.ac.uk" \
        uk.ac.sanger.cgp="Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute" \
        version="4.3.3" \
        description="Ascat NGS docker"
  
  RUN apt-get -yq update \
  
negative.code: RUN apt-get install -yq --no-install-recommends libbz2-dev
  RUN apt-get install -yq --no-install-recommends unzip
  RUN apt-get install -yq --no-install-recommends libpng-dev
  RUN apt-get install -yq --no-install-recommends tzdata
  RUN apt-get install -yq --no-install-recommends r-base
  RUN apt-get install -yq --no-install-recommends libcurl4-openssl-dev
  RUN apt-get install -yq --no-install-recommends libxml2-dev
  