anchor.diff:  ENV R_VERSION=R-3.6.3
   
   RUN curl https://cran.r-project.org/src/base/R-3/$R_VERSION.tar.gz -o $R_VERSION.tar.gz && \
  -        tar xvf $R_VERSION.tar.gz && \
  -        cd $R_VERSION && \
  +    tar xvf $R_VERSION.tar.gz && \
  +    cd $R_VERSION && \
   	./configure && make && make install
  -
   
   RUN R -e 'install.packages("BiocManager", repos="http://cran.us.r-project.org")'
   RUN R -e 'BiocManager::install("tidyverse")'
  
positive.code: ENV PATH=${TRINITY_HOME}:${PATH}
  
  
  
  
  
  # some cleanup
  WORKDIR $SRC
  RUN rm -r ${R_VERSION} *.tar.gz *.zip *.bz2
  
  RUN apt-get clean
  
  ################################################
  ## be sure this is last!
  COPY Dockerfile $SRC/Dockerfile.$TRINITY_VERSION  
  
  
negative.code: 
  ENV DEBIAN_FRONTEND=noninteractive
  
  RUN apt-get -qq update && apt-get -qq -y install \
      automake \
      build-essential \
      bzip2 \
      cmake \
      curl \
      default-jre \
      fort77 \
      ftp \
      g++ \
      gcc \
      gfortran \
      git \
      libblas-dev \
      libbz2-dev \
      libcairo2-dev \
      libcurl4-openssl-dev \
      libdb-dev \
      libghc-zlib-dev \
      libjpeg-dev \
      liblzma-dev \
      libncurses-dev \
      libncurses5-dev \
      libpcre3-dev \
      libpng-dev \
      libreadline-dev \
      libreadline-dev \
      libssl-dev \
      libtbb-dev \
      libx11-dev \
      libxml2-dev \
      libxt-dev \
      libzmq3-dev \
      make \
      nano \
      perl \
      pkg-config \
      python3 \
      python3-dev \
      python3-distutils \
      python3-pip \
      python3-setuptools \
      rsync \
      texlive-latex-base \
      tzdata \
      unzip \
      wget \
      x11-common \
      zlib1g-dev
  
  
  ## Perl stuff
  