anchor.diff: -FROM bioconductor/bioconductor_docker:RELEASE_3_15
  -#FROM bioconductor/bioconductor_docker:devel
  +#FROM bioconductor/bioconductor_docker:RELEASE_3_15
  +FROM bioconductor/bioconductor_docker:devel
   
   # install base packages
   RUN Rscript -e 'if (!requireNamespace("BiocManager", quietly = TRUE)){install.packages("BiocManager")}; \
  
positive.code: remotes::install_github("nalinigans/GenomicsDB-R", ref="master", configure.args="--with-genomicsdb=/opt/GenomicsDB/")'
  
  # install PureCN
  RUN Rscript -e 'BiocManager::install("PureCN", dependencies = TRUE)'
  #RUN Rscript -e 'BiocManager::install("lima1/PureCN", dependencies = TRUE)'
  ENV PURECN=/usr/local/lib/R/site-library/PureCN/extdata
  
  # add symbolic link and paths
  
negative.code:     && apt-get clean \
      && rm -rf /var/lib/apt/lists/*
  
  RUN apt-get install -y --no-install-recommends \
      texlive \
      texlive-latex-extra \
      texlive-fonts-extra \
      texlive-bibtex-extra \
      texlive-science \
      texi2html \
      texinfo \
      && apt-get clean \
      && rm -rf /var/lib/apt/lists/*
  
  # install GenomicsDB
  ENV GENOMICSDB_PATH=/opt/GenomicsDB
  