anchor.diff:  remotes::install_github("nalinigans/GenomicsDB-R", ref="master", configure.args="--with-genomicsdb=/opt/GenomicsDB/")'
   
   # install PureCN
  -RUN Rscript -e 'BiocManager::install("lima1/PureCN", dependencies = TRUE)'
  +RUN Rscript -e 'BiocManager::install("PureCN", dependencies = TRUE)'
  +#RUN Rscript -e 'BiocManager::install("lima1/PureCN", dependencies = TRUE)'
   ENV PURECN=/usr/local/lib/R/site-library/PureCN/extdata
   
   # add symbolic link and paths
  
positive.code: RUN Rscript -e 'BiocManager::install("lima1/PSCBS", ref="add_dnacopy_weighting")'
  
  RUN apt-get update \
      && apt-get install -y --no-install-recommends apt-utils \
      && apt-get install -y --no-install-recommends \
      texlive \
      texlive-latex-extra \
      texlive-fonts-extra \
      texlive-bibtex-extra \
      texlive-science \
      texi2html \
      texinfo \
      python-is-python3 \
      && apt-get clean \
      && rm -rf /var/lib/apt/lists/*
  
  # install GenomicsDB
  ENV GENOMICSDB_PATH=/opt/GenomicsDB
  
negative.code: FROM bioconductor/bioconductor_docker:RELEASE_3_15
  #FROM bioconductor/bioconductor_docker:devel
  
  # install base packages
  RUN Rscript -e 'if (!requireNamespace("BiocManager", quietly = TRUE)){install.packages("BiocManager")}; \
  