anchor.diff:      && apt-get clean \
       && rm -rf /var/lib/apt/lists/*
   
  -# RUN apt-get install -y --no-install-recommends \
  -#     texlive \
  -#     texlive-latex-extra \
  -#     texlive-fonts-extra \
  -#     texlive-bibtex-extra \
  -#     texlive-science \
  -#     texi2html \
  -#     texinfo \
  -#     && apt-get clean \
  -#     && rm -rf /var/lib/apt/lists/*
  +RUN apt-get install -y --no-install-recommends \
  +    texlive \
  +    texlive-latex-extra \
  +    texlive-fonts-extra \
  +    texlive-bibtex-extra \
  +    texlive-science \
  +    texi2html \
  +    texinfo \
  +    && apt-get clean \
  +    && rm -rf /var/lib/apt/lists/*
   
   # install GenomicsDB
   ENV GENOMICSDB_PATH=/opt/GenomicsDB
  
positive.code: remotes::install_github("nalinigans/GenomicsDB-R", ref="master", configure.args="--with-genomicsdb=/opt/GenomicsDB/")'
  
  # install PureCN
  RUN Rscript -e 'BiocManager::install("PureCN", dependencies = TRUE)'
  #RUN Rscript -e 'BiocManager::install("lima1/PureCN", dependencies = TRUE)'
  ENV PURECN=/usr/local/lib/R/site-library/PureCN/extdata
  
  # add symbolic link and paths
  
negative.code: #FROM bioconductor/bioconductor_docker:RELEASE_3_15
  FROM bioconductor/bioconductor_docker:devel
  
  # install base packages
  RUN Rscript -e 'if (!requireNamespace("BiocManager", quietly = TRUE)){install.packages("BiocManager")}; \
  