anchor.diff:  
   ==== Quality control and SNP mapping
   
  -An automated pipeline, run at the NCBI, adds additional SNP specific information associated with the rsID extracted. This information includes the SNP's base pair and cytogenetic location in the current human genome reference assembly, mapped genes and SNP function. This information is then used for queries and in the production of the karyotype diagram. The pipeline also performs checks for missing information, such as SNP identifiers, resolution of the citation in PubMed, existence of SNPs in dbSNP, confirmation of gene names vs. NCBI's Gene database and confirmation that the reported SNP and gene are in the same chromosomal region.
  +An automated pipeline, run at the NCBI, adds additional SNP specific information associated with the rsID extracted. This information includes the SNP's base pair and cytogenetic location in the current human genome reference assembly, mapped genes and SNP function. This information is then used for queries of the search interface and in the production of the karyotype diagram. The pipeline also performs checks for consistency and missing information, such as SNP identifiers, resolution of the citation in PubMed, existence of SNPs in dbSNP, confirmation of gene names vs. NCBI's Gene database and confirmation that the reported SNP and gene are in the same chromosomal region.
   
   Additional information added by NCBI pipeline. Capitalised titles correspond to column headings in tab delimited file:
   
   * REGION: Cytogenetic region associated with rs number.
   * CHR_ID: Chromosome number associated with rs number.
  -* CHR_POS: Chromosomal position, in base pairs, associated with rs number (dbSNP Build 132, NCBI).
  +* CHR_POS: Chromosomal position, in base pairs, associated with rs number.
   * MAPPED GENE(S): Gene(s) mapped to the strongest SNP. If the SNP is located within a gene, that gene is listed, with multiple overlapping genes separated by “;”. If the SNP is intergenic, the upstream and downstream genes are listed, separated by “-”.
   * UPSTREAM_GENE_ID: Entrez Gene ID for nearest upstream gene to rs number, if not within gene.
   * DOWNSTREAM_GENE_ID: Entrez Gene ID for nearest downstream gene to rs number, if not within gene.
  
positive.code: * REPORTED GENE: Gene(s) reported by the author; "Intergenic" is used to denote a reported intergenic location (or lack of gene if it appeared that gene information was sought); “NR” is used to denote that no gene location information was reported.
  * STRONGEST SNP-RISK ALLELE: SNP(s) most strongly associated with trait + risk/effect allele (? for unknown risk allele). May also refer to a haplotype.
  * SNPS: Strongest SNP; If a haplotype is reported above, this field may include more than one rs number (multiple SNPs comprising the haplotype). Multiple SNPs may also be included if proxy SNPs are reported.
  * RISK ALLELE FREQUENCY: Reported risk/effect allele frequency associated with strongest SNP in controls (if not available among all controls, among the control group with the largest sample size). ; If the associated locus is a haplotype the haplotype frequency will be extracted.
  * P-VALUE: Reported p-value for strongest SNP risk allele. Note that p-values are rounded to 1 significant digit (for example, a published p- value of 4.8 x 10-7 is rounded to 5 x 10-7).
  * P-VALUE (TEXT): Information describing context of p-value (e.g. females, smokers).
  * OR or BETA: Reported odds ratio or beta-coefficient associated with strongest SNP risk allele. Note that if an OR <1 is reported this is inverted, along with the reported allele, so that all ORs included in the Catalog are >1. Appropriate unit and increase/decrease are included for beta coefficients.
  
negative.code: === Identification of studies
  
  Published GWAS studies are identified through a weekly PubMed search.
  The search terms are "genome-wide" OR "genome AND identification" OR "genome AND association", with limits on the current year and human status.
  
  === Eligibility criteria
  
  