anchor.diff:            -  Subject has history of drug-induced interstitial lung disease (ILD) or any evidence
                of active ILD.
   
  -          -  Subject has ongoing cardiac arrhythmia that is Grade â‰¥ 2 or uncontrolled atrial
  +          -  Subject has ongoing cardiac arrhythmia that is Grade  2 or uncontrolled atrial
                fibrillation of any grade.
   
             -  Subject currently has Class 3 or 4 New York Heart Association congestive heart
  
positive.code: 
            5. Adequate hepatic and renal function:
  
                 -  AST and ALT â‰¤2.5 x ULN for subjects without liver metastases and â‰¤3.5 x ULN for
                    subjects with liver metastases
  
                 -  Bilirubin â‰¤1.5 x ULN (unless bilirubin rise is due to Gilbert's syndrome or of
                    non-hepatic origin)
  
                 -  Creatinine â‰¤2.0 x ULN or Creatinine Clearance â‰¥40 mL/min
  
            6. PT/INR <1.5 x ULN and PTT/ aPTT <1.5 x ULN
  
  
negative.code:                        treatment of which should have been completed 6 months prior to signing
                         ICF).
  
                     21. Radiotherapy _ 4 weeks or limited field radiation for palliation _ 2 weeks
                         prior to starting IP, and/or from whom  30% of the bone marrow was
                         irradiated. Prior radiation therapy to a target lesion is permitted only if
                         there has been clear progression of the lesion since radiation was
                         completed.
  