def remove_lcr_regions(orig_bed, items):
    """If configured and available, update a BED file to remove low complexity regions.
    """
    lcr_bed = tz.get_in(["genome_resources", "variation", "lcr"], items[0])
    if lcr_bed and os.path.exists(lcr_bed) and "lcr" in get_exclude_regions(items):
        return _remove_regions(orig_bed, [lcr_bed], "nolcr", items[0])
    else:
        return orig_bed