• Title/Summary/Keyword: Korean red ginseng

### Effect of Korean Red Ginseng on Rabbit and Rat Corpus Cavernosal Smooth (고려인삼 복용이 토끼 및 횐쥐의 음경해면체 평활근에 미치는 효과)

• 최영득;마상열
• Journal of Ginseng Research
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• v.21 no.2
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• pp.98-103
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• 1997
• On the precontracted rabbit cavernosal muscle strips with phenylephrine ($5\ast10^{-6}$M), Increasing concentrations of acetylcholine (10-7, 10-6, 10-5, 10-4M) showed relaxation effect dose-dependently in control group ($10^{-7}$M : 15.32%, $10^{-6}$M : 35.44%, 10-5M : 59.45%, 10-4M : 76.54%). After 3 months administering Korean red ginseng, the relaxation action of acetylcholine was significantly increased ($10^{-7}$M : 34.18%, $10^{-6}$M : 56.35%, $10^{-5}$M : 75.33%, $10^{-4}$M : 89.86%). Relaxation effect of Korean red ginseng was significantly increased after 3 months administering Korean red ginseng. Intracavernous pressure response to electrostimulation wan 107.52 cm$H_2O$ in control group and significantly increased to 138.34 cm $H_2O$ after 3 month administering Korean red ginseng. With these results, we can confirm that long-term administration of Korean red ginseng enhances the erectly capacity and that its action is mediated by endothelium derived relaxing factor and peripheral neurophysiologic enhancement.

### Effect of Korean Red Ginseng on Somatic Symptoms in a General Population in Korea (일반인에서 홍삼이 신체증상에 미치는 효과)

• Kang, Eun-Ho;Shin, Woo-Yong;Song, Yoon-Jae;Yu, Bum-Hee
• Journal of Ginseng Research
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• v.33 no.3
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• pp.219-222
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• 2009
• Various somatic symptoms are known to be related to stress in a general population. Korean red ginseng has been used as a therapeutic agent for the treatment and prevention of many diseases in Oriental medicine. There exist no data, however, on the effect of Korean red ginseng on somatic symptoms in a general population. In this study, 21 normal subjects were randomly assigned to the Korean-red-ginseng group, and 18 subjects to the placebo group. The subjects took 3 g Korean red ginseng or placebo every day for three weeks. After the three-week treatment, there was a

### Effects of Korean Red Ginseng marc with aluminum sulfate against pathogen populations in poultry litters

• Chung, Tae Ho;Park, Chul;Choi, In Hag
• Journal of Ginseng Research
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• v.39 no.4
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• pp.414-417
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• 2015
• Background: The aim of this study was to evaluate the effects of Korean Red Ginseng marc with aluminum sulfate as litter amendments on ammonia, soluble reactive phosphorus, and pathogen populations in poultry litters. Methods: Increasing levels of Korean Red Ginseng marc with aluminum sulfate were applied onto the surface of rice hull as a top-dress application; untreated rice hulls served as controls. Results: Treatment with Korean Red Ginseng marc with aluminum sulfate or aluminum sulfate alone resulted in lower litter pH (p < 0.05), as compared with that of the controls. There were some differences (p < 0.05) between treatments with Korean Red Ginseng marc with aluminum sulfate or aluminum sulfate alone and controls at 2-4 wk (not at 1 wk). Ammonia levels reduced on an average by 29%, 30%, and 32% for 10 g, 20 g Korean Red Ginseng marc with aluminum sulfate, and aluminum sulfate alone, respectively, as compared with controls at 4 wk. During the experiment, Korean Red Ginseng marc with aluminum sulfate or aluminum sulfate treatment had an effect (p < 0.05) on soluble reactive phosphorus content, as compared with the controls (not at 4 wk). A decrease in Salmonella enterica and Escherichia coli was observed (p < 0.05) in litter amended with both Korean Red Ginseng marc with aluminum sulfate and aluminum sulfate alone, as compared with the control, except at 1-3 wk for Salmonella enterica and 1 wk and 4 wk for Escherichia coli, respectively. Conclusion: The results showed that using Korean Red Ginseng marc with aluminum sulfate (blends), which act as acidifying agents by reducing the pH of the litter, was equally effective as aluminum sulfate in reducing the environmental impact.

### Development of a Korean Red-Ginseng’s Shape Sorting System Using Image Processing (영상처리를 이용한 홍삼의 외형선별 시스템 개발)

• 장요한;장동일;방승훈
• Journal of Biosystems Engineering
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• v.26 no.3
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• pp.279-286
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• 2001
• The purpose of this study were to organize a sorting system, to develop an algorithm of image processing for the shape sorting, and to finally develop a scientific and objective shape sorting system of Korean Red-Ginseng for mechanization of the shape sorting. The results of this study are followed. 1. The shape sorting system of Korean Red-Ginseng consists of a control computer, a color CCD camera(WV-CP4110) for image processing, an image processing board(DT3153), and an image acquisition unit. 2. Many image processing skill, such as sliding, stretching, threshold, binary and D$\sub$t/ were used to analyze the shape sorting factors of Korean Red-ginseng. 3. The sorting accuracy of the shape sorting system for the Korean Red-Ginseng was 74.7%. It is 21.1% lower than that of human inspector. Although the system has low accuracy, using more cameras may improve its sorting accuracy.

### Effect of Korean Red Ginseng Component on Lipolytic Action of Toxohormone-L from Cancerous Ascites Fluid (고려홍삼 성분이 암독소 호르몬-L의 체지방 분해작용에 미치는 영향)

• 이성동;황우익
• The Korean Journal of Food And Nutrition
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• v.8 no.2
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• pp.105-109
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• 1995
• This study was devised to observe the inhibitory effects of 3 kinds of petroleum ether extracts (percolation by petroleum ether) from Korean red ginseng, Chinese red ginseng and American white ginseng on a lipolytic action of Toxohormone-L which has been known as lipolytic and anorexigenic factors. Toxohormone-L was obtained by partial purification of the ascites fluid from mice which had been Inoculated with sarcoma-180. The yields of petroleum ether extract from Korean red ginseng, Chinese red ginseng and American white ginseng were 0.64, 0.47 and 0.58 and respectively, indicating that the yield of Korean red ginseng was the highest. In vitro, at the concentration of 2 mg /ml, the inhibition rate of lipolysis by the petroleum ether extract of Korean red ginseng, Chinese red ginseng and American white ginseng were 55.1, 50.0 and 44.9% respectively, and the total inhibitory activity per gram of ginseng material were 18, 12 and 13 unit respectively, indicating that the Korean red ginseng was the most effective in the inhibition of the lipolysis.

### Effect of Korean Red Ginseng Polysaccharide on Lipolytic Action of Toxohormone-L from Cancerous Ascites Fluid (고려홍삼 다당체 성분이 암독소 호르몬-L의 체지방 분해작용에 미치는 영향)

• 이성동;신유정
• The Korean Journal of Food And Nutrition
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• v.8 no.2
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• pp.110-115
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• 1995
• This study was devised to observe the inhibitory effects of ethanol treatment precipitate (crude acidic polysaccharide) from Korean red ginseng on a lipolytic action of Toxohormone-L which has been known as lipolytic and anorexigenic factors. Toxohormone-L was obtained by partial purification of the ascites fluid from mice which had been inoculated with sarcoma-180. The yields of crude acidic polysaccharide from Korean red ginseng was 63.5%. In vitro, at the concentration of 500rg /ml, the inhibition rate of lipolysis by the crude acidic polysaccharide of Korean red ginseng was 38.8% and the total inhibitory activity per gram of ginseng material was 4,928 nit. In vivo, the red ginseng polysaccharide(40mg/ml in saline soon.) 16ul/g of body weight was injected to the sarcoma-180 bearing mice once In 3 days until death. The effects against the extension of life span was little but body weight gain of sarcoma-180 bearing mice decreased significantly by administration of Korean red ginseng polysaccharide compared to those of the control group.

### Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

• Lee, So-Jung;Park, Ji-Young;Choi, Ki-Seok;Ock, Chan-Young;Hong, Kyung-Sook;Kim, Yoon-Jae;Chung, Jun-Won;Hahm, Ki-Baik
• Journal of Ginseng Research
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• v.34 no.2
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• pp.122-131
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• 2010
• This clinical study was performed to evaluate whether supplementation of proton pump inhibitor (PPI)-based triple therapy with Korean red ginseng can enhance Helicobacter pylori (H. pylori) eradication and reduce levels of halitosis-associated volatile sulfur compounds (VSCs) in the stomach. Seventy-six patients were randomized into an eradication regimen-only group (n=45) or an eradication regimen plus 10 weeks of Korean red ginseng supplementation group (n=31). The eradication regimen consisted of PPI b.i.d., clarithromycin 500 mg b.i.d., and amoxicillin 1 g b.i.d.. for seven days. Korean red ginseng supplementation commenced on the last day of the eradication regimen. $^{13}C$-urea breath test and halimeter measurements were performed prior to protocol repetition. By intention-to-treat analysis, the H. pylori eradication rate in the Korean red ginseng group (77.4%, 24 of 31) was higher than that in the control group (45.0%, 26 of 45). However, by per protocol analysis, the eradication rate in the Korean red ginseng group was significantly higher than that in the control group (92.3%, 24/26 vs. 69.4%, 26/38; p<0.05). H. pylori infection was significantly associated with increased VSC levels. However, VSC levels decreased significantly in the Korean red ginseng group (p<0.05). In conclusion, supplementation of triple therapy with Korean red ginseng increased the H. pylori eradication rate and led to significant reductions in VSC levels, suggesting the usefulness of this substance in combating H. pylori infection.

### Photoprotective Effect of Topical EGb 761 and Korean Red Ginseng in C57BL/6 Mice

• Choi, Wook-Hee;Han, Seon-Kyu;Yi, Seh-Yoon;Ann, Hyoung-Soo;Ahn, Ryoung-Me
• Proceedings of the Korean Environmental Health Society Conference
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• 2005.06a
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• pp.306-310
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• 2005
• Exposure to UVB radiation can cause diverse biological photodamage to skin. Eeb 761 and Korean red ginseng are the major and most effective natural drug against a variety of oxidative damage. But, the protective effects against UVB radiation have not been clearly identified. In this study, we investigated the protective effect of topical EGb 761 and Korean red ginseng on pigmentation by UVB radiation. Pro-inflammatory cytokines($IL-l{\beta}$, IL-6 and $TNF-{\alpha}$) and melanogenesis proteins(tyrosinase, TRP-1 and TRP-2) mRNA were measured by reverse transcription-polymerase chain reaction(RT-PCR) analysis. The in vivo protection against pigmentation was calculated using chromameter. The mRNA level of IL-lf and TNF-a were increased by UVB irradiation in treated and non-treated group, while no significant changes were observed in IL-6 level. Topical treatment with EGb 761 and Korean red ginseng remarkably reduced expression of tyrosinase, TRP-1 and TRP-2 in the non-irradiated and irradiated skin. Application of EGb 761 and Korean red ginseng significantly protected the WB-induced skin pigmentation and Korean red ginseng was more effective. Our study suggests that topical ECb761 and Korean red ginseng can regulate melanogenic proteins and protect UVB radiation on skin pigmentation.

### Korean Red Ginseng Powder in the Treatment of Melasma: An Uncontrolled Observational Study

• Song, Margaret;Mun, Je-Ho;Ko, Hyun-Chang;Kim, Byung-Soo;Kim, Moon-Bum
• Journal of Ginseng Research
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• v.35 no.2
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• pp.170-175
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• 2011
• Exposure to the sun, ultraviolet radiation, and oxidative stress are the chief etiologic factors responsible for melasma. The ingredients of Korean red ginseng powder, which include ginsenoside and phenolic compounds, have antioxidative effects and reduce ultraviolet B-induced pigmentation. This study was designed to evaluate the effectiveness and safety of Korean red ginseng powder in patients with melasma. In 25 female patients, 3 g of Korean red ginseng powder was orally administered for a 24 week period. The level of pigmentation and erythema were determined and clinical improvement was evaluated by the melasma area and severity index (MASI), melasma quality of life scale (MELASQoL), and patient- and investigator-rated global improvement scale. After 24 weeks, the MASI score decreased from 8.8 to 5.6, and MELASQoL showed improvement in 91% of patients (p<0.05). The mean level of pigmentation decreased from 184.3 to 159.7 and erythema levels decreased from 253.6 to 216.4 (p<0.05). Additionally, 74% of the patients showed some improvement in both patient- and investigator-rated global improvement scales at week 24. Korean red ginseng powder was well tolerated by most of the patients. In conclusion, Korean red ginseng powder showed good tolerability and beneficial effects in patients with melasma. The use of Korean red ginseng would be counted as a useful adjunctive therapy for patients with melasma.

### Korean Red Ginseng: Qualitative and Quantitative Benefits on Helicobacter pylori Infection

• Chung, Jun-Won;Kim, Yoon-Jae;Lee, So-Jung;Hahm, Ki-Baik
• Journal of Ginseng Research
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• v.34 no.2
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• pp.77-88
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• 2010
• Ginseng has been reported to reduce the risk of cancer in diverse organs, including the lip, oral cavity, pharynx, larynx, esophagus, lung, liver, pancreas, ovary, colon, rectum, and stomach, as demonstrated in clinical and epidemiological studies. studies, base on which findings, Panax ginseng has been classified as a "non-organ-specific cancer preventive." However, the recent keen interest in traditional medicinal herbs has been frequently questioned, about exact mode of action and the use of panaceic compounds has been a prime issue discussed in terms of complementary and alternative medicine. Several in vitro and in vivo studies have shown the mitigating effects of Korean red ginseng on Helicobacter pylori (H. pylori)-associated atrophic changes and carcinogenesis; However, evidence-based medicine, consisting of large-scale or well designed clinical studies, is still warranted whether Korean red ginseng is to be recognized as an essential therapeutic strategy regarding a "H. pylori-associated gastric cancer preventive." Specifically, comprehensive clinical trials of Korean red ginseng are needed to demonstrate that mucosal regeneration in patients with atrophic gastritis is feasible using Korean red ginseng supplements after the eradication of H. pylori infection. Ginseng is a good example of a natural herb and its ubiquitous properties may include the reduction or delay of inflammation carcinogenesis. Korean red ginseng contains ample amounts of active ginsenosides and we have demonstrated their effects in in vitro and in vivo studies with positive outcomes. In this review, the quantitative and qualitative benefits of Korean red ginseng in the treatment of H. pylori infection are described.
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