# Whole-genome sequencing of multiple Arabidopsis thaliana populations

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The plant Arabidopsis thaliana occurs naturally in many different habitats throughout Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse environments, a 1001 Genomes Project to sequence geographically diverse A. thaliana strains has been initiated. Here we present the first phase of this project, based on population-scale sequencing of 80 strains drawn from eight regions throughout the species' native range. We describe the majority of common small-scale polymorphisms as well as many larger insertions and deletions in the A. thaliana pan-genome, their effects on gene function, and the patterns of local and global linkage among these variants. The action of processes other than spontaneous mutation is identified by comparing the spectrum of mutations that have accumulated since A. thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations.

 Author(s): Cao, J. and Schneeberger, K. and Ossowski, S. and Günther, T. and Bender, S. and Fitz, J. and Koenig, D. and Lanz, C. and Stegle, O. and Lippert, C. and Wang, X. and Ott, F. and Müller, J. and Alonso-Blanco, C. and Borgwardt, K. and Schmid, KJ. and Weigel, D. Journal: Nature Genetics Volume: 43 Number (issue): 10 Pages: 956–963 Year: 2011 Month: October Day: 0 Department(s): Empirical Inference Bibtex Type: Article (article) Digital: 0 DOI: 10.1038/ng.911 Links: BibTex @article{CaoSOGBFKLSLWOMABSW2012, title = {Whole-genome sequencing of multiple Arabidopsis thaliana populations}, author = {Cao, J. and Schneeberger, K. and Ossowski, S. and G{\"u}nther, T. and Bender, S. and Fitz, J. and Koenig, D. and Lanz, C. and Stegle, O. and Lippert, C. and Wang, X. and Ott, F. and M{\"u}ller, J. and Alonso-Blanco, C. and Borgwardt, K. and Schmid, KJ. and Weigel, D.}, journal = {Nature Genetics}, volume = {43}, number = {10}, pages = {956–963}, month = oct, year = {2011}, month_numeric = {10} }
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