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# Title:A spatially resolved network spike in model neuronal cultures reveals nucleation centers, circular traveling waves and drifting spiral waves

Abstract: We show that in model neuronal cultures, where the probability of interneuronal connection formation decreases exponentially with increasing distance between the neurons, there exists a small number of spatial nucleation centers of a network spike, from where the synchronous spiking activity starts propagating in the network typically in the form of circular traveling waves. The number of nucleation centers and their spatial locations are unique and unchanged for a given realization of neuronal network but are different for different networks. In contrast, if the probability of interneuronal connection formation is independent of the distance between neurons, then the nucleation centers do not arise and the synchronization of spiking activity during a network spike occurs spatially uniform throughout the network. Therefore one can conclude that spatial proximity of connections between neurons is important for the formation of nucleation centers. It is also shown that fluctuations of the spatial density of neurons at their random homogeneous distribution typical for the experiments $\textit{in vitro}$ do not determine the locations of the nucleation centers. The simulation results are qualitatively consistent with the experimental observations.
 Comments: 14 pages, 7 figures Subjects: Neurons and Cognition (q-bio.NC); Disordered Systems and Neural Networks (cond-mat.dis-nn); Adaptation and Self-Organizing Systems (nlin.AO); Pattern Formation and Solitons (nlin.PS); Biological Physics (physics.bio-ph) Journal reference: Phys. Biol. 14, 026003 (2017) DOI: 10.1088/1478-3975/aa5fc3 Cite as: arXiv:1811.03335 [q-bio.NC] (or arXiv:1811.03335v1 [q-bio.NC] for this version)

## Submission history

From: Dr. Alexander Paraskevov [view email]
[v1] Thu, 8 Nov 2018 09:56:49 UTC (6,449 KB)
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