### TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy

Benedetta Salvatori, Tina Linder, Daniel Eppel, Micaela Morettini, Laura Burattini, Christian Göbl & Andrea Tura
Abstract Background The triglyceride-glucose index (TyG) has been proposed as a surrogate marker of insulin resistance, which is a typical trait of pregnancy. However, very few studies analyzed TyG performance as marker of insulin resistance in pregnancy, and they were limited to insulin resistance assessment at fasting rather than in dynamic conditions, i.e., during an oral glucose tolerance test (OGTT), which allows more reliable assessment of the actual insulin sensitivity impairment. Thus, first aim of...

### Data from: Nucleus reuniens of the thalamus contains head direction cells

Maciej M. Jankowski, , Nicholas F. Wright, Seralynne D. Vann, Jonathan T. Erichsen, John P. Aggleton, Shane M. O’Mara & Shane M O'Mara
Discrete populations of brain cells signal heading direction, rather like a compass. These ‘head direction’ cells are largely confined to a closely-connected network of sites. We describe, for the first time, a population of head direction cells in nucleus reuniens of the thalamus in the freely-moving rat. This novel subcortical head direction signal potentially modulates the hippocampal CA fields directly and, thus, informs spatial processing and memory.

### Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine

Nicolò Meneghetti, Chiara Cerri, Eleonora Vannini, Elena Tantillo, Angelita Tottene, Daniela Pietrobon, Matteo Caleo & Alberto Mazzoni
Abstract Background Migraine affects a significant fraction of the world population, yet its etiology is not completely understood. In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-function associated with a monogenic form of migraine (familial-hemiplegic-migraine-type-1: FHM1). However, how these alterations reverberate on cortical activity remains unclear. As altered responsivity to visual stimuli and abnormal processing of visual sensory information are common hallmarks of migraine, herein we investigated the effects of FHM1-driven synaptic alterations in...

### Additional file 1 of TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy

Benedetta Salvatori, Tina Linder, Daniel Eppel, Micaela Morettini, Laura Burattini, Christian Göbl & Andrea Tura
Additional file 1: Table S1. Subsets obtained from the feature selection procedure (from 2 to 5, as no subset was selected with 6 features).

### Data from: The functional role of serial dependence

Guido Marco Cicchini, Kyriaki Mikellidou & David C. Burr
The world tends to be stable from moment to moment, leading to strong serial correlations in natural scenes. As similar stimuli usually require similar behavioral responses, it is highly likely that the brain has developed strategies to leverage these regularities. A good deal of recent psychophysical evidence is beginning to show that the brain is sensitive to serial correlations, causing strong drifts in observer responses towards previously seen stimuli. However, it is still not clear...

### Data from: D quantification of tumor vasculature in lymphoma xenografts in NOD/SCID mice allows to detect differences among vascular-targeted therapies

Marco Righi, Arianna Giacomini, Loredana Cleris & Carmelo Carlo-Stella
Quantitative characterization of the in vivo effects of vascular-targeted therapies on tumor vessels is hampered by the absence of useful 3D vascular network descriptors aside from microvessel density. In this study, we extended the quantification of planar vessel distribution to the analysis of vascular volumes by studying the effects of antiangiogenic (sorafenib and sunitinib) or antivascular (combretastatin A4 phosphate) treatments on the quantity and spatial distributions of thin microvessels. These observations were restricted to perinecrotic...

### Data from: Scalability of asynchronous networks is limited by one-to-one mapping between effective connectivity and correlations

Sacha Jennifer Van Albada, Moritz Helias & Markus Diesmann
Network models are routinely downscaled compared to nature in terms of numbers of nodes or edges because of a lack of computational resources, often without explicit mention of the limitations this entails. While reliable methods have long existed to adjust parameters such that the first-order statistics of network dynamics are conserved, here we show that limitations already arise if also second-order statistics are to be maintained. The temporal structure of pairwise averaged correlations in the...

### Data from: Bistability, non-ergodicity, and inhibition in pairwise maximum-entropy models

Vahid Rostami, PierGianLuca Porta Mana, Sonja Grün & Moritz Helias
Pairwise maximum-entropy models have been used in neuroscience to predict the activity of neuronal populations, given only the time-averaged correlations of the neuron activities. This paper provides evidence that the pairwise model, applied to experimental recordings, would produce a bimodal distribution for the population-averaged activity, and for some population sizes the second mode would peak at high activities, that experimentally would be equivalent to 90% of the neuron population active within time-windows of few milliseconds....

### Additional file 1 of Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine

Nicolò Meneghetti, Chiara Cerri, Eleonora Vannini, Elena Tantillo, Angelita Tottene, Daniela Pietrobon, Matteo Caleo & Alberto Mazzoni
Fig. S1 related to Figs. 3, 4. (A) (left) PSD modulation for the minimum contrast level (K = 0) of experimental (black) and simulated data for WT (orange, left) and FHM1 (green, right). $${\chi}_r^2=0.34$$ χ r 2 = 0.34 for WT and $${\chi}_r^2=0.28$$ χ r 2 = 0.28 for FHM1. (B) Cortical narrow band power modulation as a function of thalamic narrow band strength in the FHM1 model. The model was set with (red) and...

### Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

Austin R. Graves, Richard H. Roth, Han L. Tan, Qianwen Zhu, Alexei M. Bygrave, Elena Lopez-Ortega, Ingie Hong, Alina C. Spiegel, Richard C. Johnson, Joshua T. Vogelstein, Daniel J. Tward, Michael I. Miller & Richard Huganir
Elucidating how synaptic molecules such as AMPA receptors mediate neuronal communication and tracking their dynamic expression during behavior is crucial to understand cognition and disease, but current technological barriers preclude large-scale exploration of molecular dynamics in vivo. We have developed a suite of innovative methodologies that break through these barriers: a new knockin mouse line with fluorescently tagged endogenous AMPA receptors, two-photon imaging of hundreds of thousands of labeled synapses in behaving mice, and computer...

### TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy

Benedetta Salvatori, Tina Linder, Daniel Eppel, Micaela Morettini, Laura Burattini, Christian Göbl & Andrea Tura
Abstract Background The triglyceride-glucose index (TyG) has been proposed as a surrogate marker of insulin resistance, which is a typical trait of pregnancy. However, very few studies analyzed TyG performance as marker of insulin resistance in pregnancy, and they were limited to insulin resistance assessment at fasting rather than in dynamic conditions, i.e., during an oral glucose tolerance test (OGTT), which allows more reliable assessment of the actual insulin sensitivity impairment. Thus, first aim of...

### Data from: Stronger neural modulation by visual motion intensity in autism spectrum disorders

Ina Peiker, Till R. Schneider, Elizabeth Milne, Daniel Schöttle, Kai Vogeley, Alexander Münchau, Odette Schunke, Markus Siegel, Andreas K. Engel & Nicole David
Theories of autism spectrum disorders (ASD) have focused on altered perceptual integration of sensory features as a possible core deficit. Yet, there is little understanding of the neuronal processing of elementary sensory features in ASD. For typically developed individuals, we previously established a direct link between frequency-specific neural activity and the intensity of a specific sensory feature: Gamma-band activity in the visual cortex increased approximately linearly with the strength of visual motion. Using magnetoencephalography (MEG),...

### Data from: ASSET: analysis of sequences of synchronous events in massively parallel spike trains

Emiliano Torre, Carlos Canova, Michael Denker, Goerge Gerstein, Moritz Helias, Sonja Grün & George Gerstein
With the ability to observe the activity from large numbers of neurons simultaneously using modern recording technologies, the chance to identify sub-networks involved in coordinated processing increases. Sequences of synchronous spike events (SSEs) constitute one type of such coordinated spiking that propagates activity in a temporally precise manner. The synfire chain was proposed as one potential model for such network processing. Previous work introduced a method for visualization of SSEs in massively parallel spike trains,...

### Data from: Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication

Mario Senden, Niels Reuter, Martijn P. Van Den Heuvel, Rainer Goebel, Gustavo Deco & Matthieu Gilson
Higher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs—referred to as the rich club—has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from functional magnetic resonance imaging activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective...

### Additional file 1 of Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine

Nicolò Meneghetti, Chiara Cerri, Eleonora Vannini, Elena Tantillo, Angelita Tottene, Daniela Pietrobon, Matteo Caleo & Alberto Mazzoni
Fig. S1 related to Figs. 3, 4. (A) (left) PSD modulation for the minimum contrast level (K = 0) of experimental (black) and simulated data for WT (orange, left) and FHM1 (green, right). $${\chi}_r^2=0.34$$ χ r 2 = 0.34 for WT and $${\chi}_r^2=0.28$$ χ r 2 = 0.28 for FHM1. (B) Cortical narrow band power modulation as a function of thalamic narrow band strength in the FHM1 model. The model was set with (red) and...

### Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine

Nicolò Meneghetti, Chiara Cerri, Eleonora Vannini, Elena Tantillo, Angelita Tottene, Daniela Pietrobon, Matteo Caleo & Alberto Mazzoni
Abstract Background Migraine affects a significant fraction of the world population, yet its etiology is not completely understood. In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-function associated with a monogenic form of migraine (familial-hemiplegic-migraine-type-1: FHM1). However, how these alterations reverberate on cortical activity remains unclear. As altered responsivity to visual stimuli and abnormal processing of visual sensory information are common hallmarks of migraine, herein we investigated the effects of FHM1-driven synaptic alterations in...

### Additional file 1 of TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy

Benedetta Salvatori, Tina Linder, Daniel Eppel, Micaela Morettini, Laura Burattini, Christian Göbl & Andrea Tura
Additional file 1: Table S1. Subsets obtained from the feature selection procedure (from 2 to 5, as no subset was selected with 6 features).

### Data from: Identifying anatomical origins of coexisting oscillations in the cortical microcircuit

Hannah Bos, Markus Diesmann & Moritz Helias
Oscillations are omnipresent in neural population signals, like multi-unit recordings, EEG/MEG, and the local field potential. They have been linked to the population firing rate of neurons, with individual neurons firing in a close-to-irregular fashion at low rates. Using a combination of mean-field and linear response theory we predict the spectra generated in a layered microcircuit model of V1, composed of leaky integrate-and-fire neurons and based on connectivity compiled from anatomical and electrophysiological studies. The...

### Data from: Fundamental activity constraints lead to specific interpretations of the connectome

Jannis Schuecker, Maximilian Schmidt, Sacha J. Van Albada, Markus Diesmann & Moritz Helias
The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to experimental observations. Nevertheless, structurally realistic network models of spiking neurons are necessarily underconstrained even if experimental data on brain connectivity are incorporated to the best of our knowledge. Guided by physiological observations, any model must therefore explore the parameter ranges...

### Data from: Locking of correlated neural activity to ongoing oscillations

Tobias Kühn & Moritz Helias
Population-wide oscillations are ubiquitously observed in mesoscopic signals of cortical activity. In these network states a global oscillatory cycle modulates the propensity of neurons to fire. Synchronous activation of neurons has been hypothesized to be a separate channel of signal processing information in the brain. A salient question is therefore if and how oscillations interact with spike synchrony and in how far these channels can be considered separate. Experiments indeed showed that correlated spiking co-modulates...

### The role of prognostic stratification on prescription of anticoagulants in older patients with atrial fibrillation: a multicenter, observational, prospective European study (EUROSAF)

Alberto Pilotto, Nicola Veronese, Maria Cristina Polidori, Timo Strandberg, Eva Topinkova, Alfonso J. Cruz-Jentoft, Carlo Custodero & Stefania Maggi
Literature suggests that different risks of mortality could influence physicians in prescribing or not anticoagulants in older patients with atrial fibrillation (AF). The Multidimensional Prognostic Index (MPI) can be considered a tool for the detection of multidimensional frailty. The aim of this cross-sectional study was to evaluate whether prescription patterns of oral anticoagulants exist, based on MPI values. Older hospitalised patients (age ≥ 65 years) with non-valvular AF were included across 24 European centres. MPI...

### The role of prognostic stratification on prescription of anticoagulants in older patients with atrial fibrillation: a multicenter, observational, prospective European study (EUROSAF)

Alberto Pilotto, Nicola Veronese, Maria Cristina Polidori, Timo Strandberg, Eva Topinkova, Alfonso J. Cruz-Jentoft, Carlo Custodero & Stefania Maggi
Literature suggests that different risks of mortality could influence physicians in prescribing or not anticoagulants in older patients with atrial fibrillation (AF). The Multidimensional Prognostic Index (MPI) can be considered a tool for the detection of multidimensional frailty. The aim of this cross-sectional study was to evaluate whether prescription patterns of oral anticoagulants exist, based on MPI values. Older hospitalised patients (age ≥ 65 years) with non-valvular AF were included across 24 European centres. MPI...

• 2022
11
• 2018
1
• 2017
4
• 2016
2
• 2015
2
• 2014
1
• 2013
1

• Dataset
14
• Collection
4
• Text
4

#### Affiliations

• Institute of Neuroscience
12
• Neuroscience Institute
10
• RWTH Aachen University
6
• University of Pisa
5
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