Överlevnad och tumörprogression har undersökts i fem stora kontrollerade studier på totalt 2833 patienter, varav fyra var dubbelblinda, placebokontrollerade studier och en var en öppen studie. ###>Survival and tumour progression have been examined in five large controlled studies involving a total of 2833 patients, of which four were double-blind placebo-controlled studies and one was an open- label study.