I kliniska studier definierades patienter med en uttalad brist på FSH och LH som de vars endogena serumnivå av LH var < 1, 2 IE/ l, vilken uppmättes i ett centralt laboratorium. ###>In clinical trials, patients with severe FSH and LH deficiency were defined by an endogenous serum LH level < 1.2 IU/ l as measured in a central laboratory.