Problem i hud och underhud Akut försämring av aknen framträder då och då under den initiala behandlingen men avklingar under fortsatt behandling, vanligtvis inom 7 – 10 dagar. ###>Skin and subcutaneous tissues disorders Acute exacerbation of acne is occasionally seen during the initial period but this subsides with continued treatment, usually within 7 - 10 days, and usually does not require dose adjustment.