Båda dessa metaboliter uppvisar betydligt lägre in vivo farmakologisk effekt än olanzapin i djurstudier. ###>Cytochromes P450- CYP 1A2 and P450-CYP2D6 contribute to the formation of the N-desmethyl and 2-hydroxymethyl metabolites, both exhibited significantly less in vivo pharmacological activity than olanzapine in animal studies.