I kliniska prövningar med 73 tidigare behandlade patienter (PTP, definierade som haft fler än 100 exponeringsdagar) följda över 4 år hittades inga de- novo inhibitorer. ###>In clinical studies with 73 previously treated patients (PTP, defined as having more than 100 exposure days), followed over four years, no de-novo inhibitors were observed.