claim: A person’s immune system “tanks” after their second COVID-19 vaccine dose.
evidence: Fig. 2: Dynamics and projection of circulating IgG levels against RBD after the second dose of the COVID-19 vaccination using a linear model. [...] In conclusion, humoral responses following COVID-19 vaccination decreased in all age groups after approximately 6 months. Non-linear models estimated a continuous waning in humoral responses primarily in the older population and individuals with a delayed administration of the second vaccine dose. Natural infections prior to completion of vaccination induced a more robust immune response, characterized primarily by the stability of the IgG levels, higher levels of IFN-γ release from activated T-cells, and the presence of IgA antibodies in circulation. The use of dynamic models taking into consideration different factors of the immune system may be of use to establish guidelines for future re-vaccination strategies. [...] Ledford, H. Delaying a COVID vaccine’s second dose boosts immune response. Naturehttps://doi.org/10.1038/d41586-021-01299-y (2021).