Author(s): Bradic, Jelena; Wager, Stefan; Zhu, Yinchu | Abstract: Many popular methods for building confidence intervals on causal effects under high-dimensional confounding require strong "ultra-sparsity" assumptions that may be difficult to validate in practice. To alleviate this difficulty, we here study a new method for average treatment effect estimation that yields asymptotically exact confidence intervals assuming that either the conditional response surface or the conditional probability of treatment allows for an ultra-sparse representation (but not necessarily both). This guarantee allows us to provide valid inference for average treatment effect in high dimensions under considerably more generality than available baselines. In addition, we showcase that our results are semi-parametrically efficient.
@cite_4: We consider inference about a scalar parameter under a non-parametric model based on a one-step estimator computed as a plug in estimator plus the empirical mean of an estimator of the parameter's influence function. We focus on a class of parameters that have influence function which depends on two infinite dimensional nuisance functions and such that the bias of the one-step estimator of the parameter of interest is the expectation of the product of the estimation errors of the two nuisance functions. Our class includes many important treatment effect contrasts of interest in causal inference and econometrics, such as ATE, ATT, an integrated causal contrast with a continuous treatment, and the mean of an outcome missing not at random. We propose estimators of the target parameter that entertain approximately sparse regression models for the nuisance functions allowing for the number of potential confounders to be even larger than the sample size. By employing sample splitting, cross-fitting and @math -regularized regression estimators of the nuisance functions based on objective functions whose directional derivatives agree with those of the parameter's influence function, we obtain estimators of the target parameter with two desirable robustness properties: (1) they are rate doubly-robust in that they are root-n consistent and asymptotically normal when both nuisance functions follow approximately sparse models, even if one function has a very non-sparse regression coefficient, so long as the other has a sufficiently sparse regression coefficient, and (2) they are model doubly-robust in that they are root-n consistent and asymptotically normal even if one of the nuisance functions does not follow an approximately sparse model so long as the other nuisance function follows an approximately sparse model with a sufficiently sparse regression coefficient.
Our result is most closely related to a recent proposal by , who studied any linear functional whose Riesz representer admits an (approximate) linear representation. In another paper, considers theoretical results for estimators based on learning conditional mean function and the propensity score. In both papers, the key condition is that the product of @math -loss for learning the two nuisance parameters is @math , a condition referred to as rate double robustness; see Definition 2 in @cite_4 . Sufficient conditions for rate double robustness have been provided in these works in terms of sparsity levels. For example, Remark 5.2 of shows that rate double robustness is guaranteed when the product of two sparsity levels is @math , while Remark 7 of points out that under the assumption of bounded @math -norm of both parameters, rate double robustness holds whenever one of the sparsity levels is @math .