Signet ring cell carcinoma is a type of rare adenocarcinoma with poor prognosis. Early detection leads to huge improvement of patients’ survival rate. However, pathologists can only visually detect signet ring cells under the microscope. This procedure is not only laborious but also prone to omission. An automatic and accurate signet ring cell detection solution is thus important but has not been investigated before. In this paper, we take the first step to present a semi-supervised learning framework for the signet ring cell detection problem. Self-training is proposed to deal with the challenge of incomplete annotations, and cooperative-training is adapted to explore the unlabeled regions. Combining the two techniques, our semi-supervised learning framework can make better use of both labeled and unlabeled data. Experiments on large real clinical data demonstrate the effectiveness of our design. Our framework achieves accurate signet ring cell detection and can be readily applied in the clinical trails. The dataset will be released soon to facilitate the development of the area.
@cite_18: Convex and continuous energy formulations for low level vision problems enable efficient search procedures for the corresponding globally optimal solutions. In this work we extend the well-established continuous, isotropic capacity-based maximal flow framework to the anisotropic setting. By using powerful results from convex analysis, a very simple and efficient minimization procedure is derived. Further, we show that many important properties carry over to the new anisotropic framework, e.g. globally optimal binary results can be achieved simply by thresholding the continuous solution. In addition, we unify the anisotropic continuous maximal flow approach with a recently proposed convex and continuous formulation for Markov random fields, thereby allowing more general smoothness priors to be incorporated. Dense stereo results are included to illustrate the capabilities of the proposed approach.
@cite_4: Deep convolutional neural networks (DCNNs) trained on a large number of images with strong pixel-level annotations have recently significantly pushed the state-of-art in semantic image segmentation. We study the more challenging problem of learning DCNNs for semantic image segmentation from either (1) weakly annotated training data such as bounding boxes or image-level labels or (2) a combination of few strongly labeled and many weakly labeled images, sourced from one or multiple datasets. We develop Expectation-Maximization (EM) methods for semantic image segmentation model training under these weakly supervised and semi-supervised settings. Extensive experimental evaluation shows that the proposed techniques can learn models delivering competitive results on the challenging PASCAL VOC 2012 image segmentation benchmark, while requiring significantly less annotation effort. We share source code implementing the proposed system at this https URL
@cite_8: Computer-aided diagnosis of histopathological images usually requires to examine all cells for accurate diagnosis. Traditional computational methods may have efficiency issues when performing cell-level analysis. In this paper, we propose a robust and scalable solution to enable such analysis in a real-time fashion. Specifically, a robust segmentation method is developed to delineate cells accurately using Gaussian-based hierarchical voting and repulsive balloon model. A large-scale image retrieval approach is also designed to examine and classify each cell of a testing image by comparing it with a massive database, e.g., half-million cells extracted from the training dataset. We evaluate this proposed framework on a challenging and important clinical use case, i.e., differentiation of two types of lung cancers (the adenocarcinoma and squamous carcinoma), using thousands of lung microscopic tissue images extracted from hundreds of patients. Our method has achieved promising accuracy and running time by searching among half-million cells .
@cite_10: The morphology of glands has been used routinely by pathologists to assess the malignancy degree of adenocarcinomas. Accurate segmentation of glands from histology images is a crucial step to obtain reliable morphological statistics for quantitative diagnosis. In this paper, we proposed an efficient deep contour-aware network (DCAN) to solve this challenging problem under a unified multi-task learning framework. In the proposed network, multi-level contextual features from the hierarchical architecture are explored with auxiliary supervision for accurate gland segmentation. When incorporated with multi-task regularization during the training, the discriminative capability of intermediate features can be further improved. Moreover, our network can not only output accurate probability maps of glands, but also depict clear contours simultaneously for separating clustered objects, which further boosts the gland segmentation performance. This unified framework can be efficient when applied to large-scale histopathological data without resorting to additional steps to generate contours based on low-level cues for post-separating. Our method won the 2015 MICCAI Gland Segmentation Challenge out of 13 competitive teams, surpassing all the other methods by a significant margin.
@cite_9: Deep neural networks have advanced many computer vision tasks, because of their compelling capacities to learn from large amount of labeled data. However, their performances are not fully exploited in semantic image segmentation as the scale of training set is limited, where perpixel labelmaps are expensive to obtain. To reduce labeling efforts, a natural solution is to collect additional images from Internet that are associated with image-level tags. Unlike existing works that treated labelmaps and tags as independent supervisions, we present a novel learning setting, namely dual image segmentation (DIS), which consists of two complementary learning problems that are jointly solved. One predicts labelmaps and tags from images, and the other reconstructs the images using the predicted labelmaps. DIS has three appealing properties. 1) Given an image with tags only, its labelmap can be inferred by leveraging the images and tags as constraints. The estimated labelmaps that capture accurate object classes and boundaries are used as ground truths in training to boost performance. 2) DIS is able to clean tags that have noises. 3) DIS significantly reduces the number of perpixel annotations in training, while still achieves state-ofthe- art performance. Extensive experiments demonstrate the effectiveness of DIS, which outperforms an existing bestperforming baseline by 12.6 on Pascal VOC 2012 test set, without any post-processing such as CRF MRF smoothing.
@cite_0: In this work, we present a novel and effective framework to facilitate object detection with the instance-level segmentation information that is only supervised by bounding box annotation. Starting from the joint object detection and instance segmentation network, we propose to recursively estimate the pseudo ground-truth object masks from the instance-level object segmentation network training, and then enhance the detection network with top-down segmentation feedbacks. The pseudo ground truth mask and network parameters are optimized alternatively to mutually benefit each other. To obtain the promising pseudo masks in each iteration, we embed a graphical inference that incorporates the low-level image appearance consistency and the bounding box annotations to refine the segmentation masks predicted by the segmentation network. Our approach progressively improves the object detection performance by incorporating the detailed pixel-wise information learned from the weakly-supervised segmentation network. Extensive evaluation on the detection task in PASCAL VOC 2007 and 2012 [12] verifies that the proposed approach is effective.
@cite_5: 
@cite_16: In this paper, we propose DeepCut, a method to obtain pixelwise object segmentations given an image dataset labelled weak annotations, in our case bounding boxes. It extends the approach of the well-known GrabCut[1] method to include machine learning by training a neural network classifier from bounding box annotations. We formulate the problem as an energy minimisation problem over a densely-connected conditional random field and iteratively update the training targets to obtain pixelwise object segmentations. Additionally, we propose variants of the DeepCut method and compare those to a naive approach to CNN training under weak supervision. We test its applicability to solve brain and lung segmentation problems on a challenging fet al magnetic resonance dataset and obtain encouraging results in terms of accuracy.
@cite_13: Most methods for object instance segmentation require all training examples to be labeled with segmentation masks. This requirement makes it expensive to annotate new categories and has restricted instance segmentation models to 100 well-annotated classes. The goal of this paper is to propose a new partially supervised training paradigm, together with a novel weight transfer function, that enables training instance segmentation models on a large set of categories all of which have box annotations, but only a small fraction of which have mask annotations. These contributions allow us to train Mask R-CNN to detect and segment 3000 visual concepts using box annotations from the Visual Genome dataset and mask annotations from the 80 classes in the COCO dataset. We evaluate our approach in a controlled study on the COCO dataset. This work is a first step towards instance segmentation models that have broad comprehension of the visual world.
@cite_12: Automatic analysis of histopathological images has been widely utilized leveraging computational image-processing methods and modern machine learning techniques. Both computer-aided diagnosis (CAD) and content-based image-retrieval (CBIR) systems have been successfully developed for diagnosis, disease detection, and decision support in this area. Recently, with the ever-increasing amount of annotated medical data, large-scale and data-driven methods have emerged to offer a promise of bridging the semantic gap between images and diagnostic information. In this paper, we focus on developing scalable image-retrieval techniques to cope intelligently with massive histopathological images. Specifically, we present a supervised kernel hashing technique which leverages a small amount of supervised information in learning to compress a 10 @math 000-dimensional image feature vector into only tens of binary bits with the informative signatures preserved. These binary codes are then indexed into a hash table that enables real-time retrieval of images in a large database. Critically, the supervised information is employed to bridge the semantic gap between low-level image features and high-level diagnostic information. We build a scalable image-retrieval framework based on the supervised hashing technique and validate its performance on several thousand histopathological images acquired from breast microscopic tissues. Extensive evaluations are carried out in terms of image classification (i.e., benign versus actionable categorization) and retrieval tests. Our framework achieves about 88.1 classification accuracy as well as promising time efficiency. For example, the framework can execute around 800 queries in only 0.01 s, comparing favorably with other commonly used dimensionality reduction and feature selection methods.
Several semi-supervised learning methods have been proposed and verified their effectiveness on natural images @cite_13 @cite_5 @cite_9 @cite_4 @cite_16 @cite_0 . @cite_4 used box-level annotation to achieve similar performance with pixel-level annotation. @cite_9 organized a reconstruction head to convert segmentation output back to original images. Generally, all the previous methods focus on training one model with complex auxiliary branches. On the contrary, our semi-supervised learning framework can organize the multiple models to support each other and no extra auxiliary branch is needed. There have been lots of automatic methods for pathology, including nuclei segmentation @cite_12 @cite_8 @cite_18 and specific object @cite_10 . However, automatic signet ring cell detection has not been investigated before to our best knowledge.