In current clinical practice, electroencephalograms (EEG) are reviewed and analyzed by well-trained neurologists to provide supports for therapeutic decisions. The way of manual reviewing is labor-intensive and error prone. Automatic and accurate seizure nonseizure classification methods are needed. One major problem is that the EEG signals for seizure state and nonseizure state exhibit considerable variations. In order to capture essential seizure features, this paper integrates an emerging deep learning model, the independently recurrent neural network (IndRNN), with a dense structure and an attention mechanism to exploit temporal and spatial discriminating features and overcome seizure variabilities. The dense structure is to ensure maximum information flow between layers. The attention mechanism is to capture spatial features. Evaluations are performed in cross-validation experiments over the noisy CHB-MIT data set. The obtained average sensitivity, specificity and precision of 88.80 , 88.60 and 88.69 are better than using the current state-of-the-art methods. In addition, we explore how the segment length affects the classification performance. Thirteen different segment lengths are assessed, showing that the classification performance varies over the segment lengths, and the maximal fluctuating margin is more than 4 . Thus, the segment length is an important factor influencing the classification performance.
@cite_13: The electroencephalogram (EEG) has proven a valuable tool in the study and detection of epilepsy. This paper investigates for the first time the use of Permutation Entropy (PE) as a feature for automated epileptic seizure detection. A Support Vector Machine (SVM) is used to classify segments of normal and epileptic EEG based on PE values. The proposed system utilizes the fact that the EEG during epileptic seizures is characterized by lower PE than normal EEG. It is shown that average sensitivity of 94.38 and average specificity of 93.23 is obtained by using PE as a feature to characterize epileptic and seizure-free EEG, while 100 sensitivity and specificity were also obtained in single-trial classifications.
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@cite_26: 
@cite_14: Epilepsy is the second most common brain disorder after migraine. Automatic detection of epileptic seizures can considerably improve the patients' quality of life. Current Electroencephalogram (EEG)-based seizure detection systems encounter many challenges in real-life situations. The EEGs are non-stationary signals and seizure patterns vary across patients and recording sessions. Moreover, EEG data are prone to numerous noise types that negatively affect the detection accuracy of epileptic seizures. To address these challenges, we introduce the use of a deep learning-based approach that automatically learns the discriminative EEG features of epileptic seizures. Specifically, to reveal the correlation between successive data samples, the time-series EEG data are first segmented into a sequence of non-overlapping epochs. Second, Long Short-Term Memory (LSTM) network is used to learn the high-level representations of the normal and the seizure EEG patterns. Third, these representations are fed into Softmax function for training and classification. The results on a well-known benchmark clinical dataset demonstrate the superiority of the proposed approach over the existing state-of-the-art methods. Furthermore, our approach is shown to be robust in noisy and real-life conditions. Compared to current methods that are quite sensitive to noise, the proposed method maintains its high detection performance in the presence of common EEG artifacts (muscle activities and eye-blinking) as well as white noise.
@cite_22: Abstract This article addresses the problem of real-time seizure detection from intracranial EEG (IEEG). One difficulty in creating an approach that can be used for many patients is the heterogeneity of seizure IEEG patterns across different patients and even within a patient. In addition, simultaneously maximizing sensitivity and minimizing latency and false detection rates has been challenging as these are competing objectives. Automated machine learning systems provide a mechanism for dealing with these hurdles. Here we present and evaluate an algorithm for real-time seizure onset detection from IEEG using a machine-learning approach that permits a patient-specific solution. We extract temporal and spectral features across all intracranial EEG channels. A pattern recognition component is trained using these feature vectors and tested against unseen continuous data from the same patient. When tested on more than 875 hours of IEEG data from 10 patients, the algorithm detected 97 of 67 test seizures of several types with a median detection delay of 5 seconds and a median false alarm rate of 0.6 false alarms per 24-hour period. The sensitivity was 100 for 8 of 10 patients. These results indicate that a sensitive, specific, and relatively short-latency detection system based on machine learning can be employed for seizure detection from EEG using a full set of intracranial electrodes to individual patients. This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction.
@cite_7: Abstract Objective A novel patient-specific seizure detection algorithm is presented. As the spatial distribution of the ictal pattern is characteristic for a patient’s seizures, this work incorporates such information into the data representation and provides a learning algorithm exploiting it. Methods The proposed training algorithm uses nuclear norm regularization to convey structural information of the channel-feature matrices extracted from the EEG. This method is compared to two existing approaches utilizing the same feature set, but integrating the multichannel information in a different manner. The performances of the detectors are demonstrated on a publicly available dataset containing 131 seizures recorded in 892 h of scalp EEG from 22 pediatric patients. Results The proposed algorithm performed significantly better compared to the reference approaches ( p = 0.0170 and p = 0.0002). It reaches a median performance of 100 sensitivity, 0.11 h −1 false detection rate and 7.8 s alarm delay, outperforming a method in the literature using the same dataset. Conclusion The strength of our method lies within conveying structural information from the multichannel EEG. Such formulation automatically includes crucial spatial information and improves detection performance. Significance Our solution facilitates accurate classification performance for small training sets, therefore, it potentially reduces the time needed to train the detector before starting monitoring.
@cite_28: Recurrent Neural Networks (RNNs) with sophisticated units that implement a gating mechanism have emerged as powerful technique for modeling sequential signals such as speech or electroencephalography (EEG). The latter is the focus on this paper. A significant big data resource, known as the TUH EEG Corpus (TUEEG), has recently become available for EEG research, creating a unique opportunity to evaluate these recurrent units on the task of seizure detection. In this study, we compare two types of recurrent units: long short-term memory units (LSTM) and gated recurrent units (GRU). These are evaluated using a state of the art hybrid architecture that integrates Convolutional Neural Networks (CNNs) with RNNs. We also investigate a variety of initialization methods and show that initialization is crucial since poorly initialized networks cannot be trained. Furthermore, we explore regularization of these convolutional gated recurrent networks to address the problem of overfitting. Our experiments revealed that convolutional LSTM networks can achieve significantly better performance than convolutional GRU networks. The convolutional LSTM architecture with proper initialization and regularization delivers 30 sensitivity at 6 false alarms per 24 hours.
@cite_9: Inter-subject variability between individuals poses a challenge in inter-subject brain signal analysis problems. A new algorithm for subject-selection based on clustering covariance matrices on a Riemannian manifold is proposed. After unsupervised selection of the subsets of relevant subjects, data in a cluster is mapped to a tangent space at the mean point of covariance matrices in that cluster and an SVM classifier on labeled data from relevant subjects is trained. Experiment on an EEG seizure database shows that the proposed method increases the accuracy over state-of-the-art from 86.83 to 89.84 and specificity from 87.38 to 89.64 while reducing the false positive rate hour from 0.8 hour to 0.77 hour.
@cite_21: Identifying a core set of features is one of the most important steps in the development of an automated seizure detector. In most of the published studies describing features and seizure classifie...
@cite_1: We present and evaluate a machine learning approach to constructing patient-specific classifiers that detect the onset of an epileptic seizure through analysis of the scalp EEG, a non-invasive measure of the brain's electrical activity. This problem is challenging because the brain's electrical activity is composed of numerous classes with overlapping characteristics. The key steps involved in realizing a high performance algorithm included shaping the problem into an appropriate machine learning framework, and identifying the features critical to separating seizure from other types of brain activity. When trained on 2 or more seizures per patient and tested on 916 hours of continuous EEG from 24 patients, our algorithm detected 96 of 173 test seizures with a median detection delay of 3 seconds and a median false detection rate of 2 false detections per 24 hour period. We also provide information about how to download the CHB-MIT database, which contains the data used in this study.
@cite_17: Abstract An encephalogram (EEG) is a commonly used ancillary test to aide in the diagnosis of epilepsy. The EEG signal contains information about the electrical activity of the brain. Traditionally, neurologists employ direct visual inspection to identify epileptiform abnormalities. This technique can be time-consuming, limited by technical artifact, provides variable results secondary to reader expertise level, and is limited in identifying abnormalities. Therefore, it is essential to develop a computer-aided diagnosis (CAD) system to automatically distinguish the class of these EEG signals using machine learning techniques. This is the first study to employ the convolutional neural network (CNN) for analysis of EEG signals. In this work, a 13-layer deep convolutional neural network (CNN) algorithm is implemented to detect normal, preictal, and seizure classes. The proposed technique achieved an accuracy, specificity, and sensitivity of 88.67 , 90.00 and 95.00 , respectively.
@cite_5: EEG is one the most effective tools used in the diagnosis of epilepsy. However, proper diagnosis of epilepsy requires the detection and analysis of epileptic seizures for a long period of time. Manual monitoring of long term EEG is tedious and costly. Therefore, a reliable automated seizure detection system is desirable. Most current state-of-the-art methods use hand crafted feature extraction and simple classification techniques, which often leads to sub-par performance due to lack of generalizability across patient dataset. Consequently, this work introduces novel deep recurrent neural network (DRNN) architecture to perform automated patient specific seizure detection using scalp EEG. We further propose a unique mapping of seizure EEG signal for efficient processing with the DRNN. This mapping allows the proposed deep architecture to simultaneously learn both temporal and spatial features of raw seizure EEG respectively. The proposed DRNN architecture is tested with long term patient specific scalp EEG data of 5 subjects with approximately 34 hours of EEG extracted from a publically available dataset. Overall, the proposed network successfully detects 100 of total seizure events with an average detection delay of 7.0 sec. The results demonstrate superior performance to that of the current state-of-art seizure detection methods. The proposed DRNN architecture also obtains a runtime of approximately 30ms for 1 sec segment of 18 channel EEG. The low processing time with sparse use of computing resources and superior performance make the proposed architecture appropriate for real-time use.
@cite_15: In this paper we present the application of ensemble learning to epileptic seizure detection problem. We propose a robust learning framework to mitigate class imbalance in large CHB-MIT (982 hrs) scalp EEG dataset. The algorithm being used is RUSBoost which is a hybrid data sampling and boosting technique designed especially for skewed classes. The data that is being used in this study has severe class imbalance, with average representation of 0.38 of seizure class to that of 99.62 of non-seizure class. The proposed approach shows the power of RUSBoost in terms of robustness and generalization. We compared our method with the most successful Support Vector Machine (SVM) based approach and report competitive results of 97 seizure detection accuracy, mean detection delay of 2.7s and false detection rate of 0.08 seizure hr. We also report fast training times of just under three minutes on average for average training data of 21 hrs.
@cite_16: Outstanding seizure detection algorithms have been developed over past two decades. Despite this success, their implementations as part of implantable or wearable devices are still limited. These works are mainly based on heavily handcrafted feature extraction, which is computationally expensive and is shown to be data set specific. These issues greatly limit the applicability of such methods to hardware implementation, including in-silicon implementations such as application specific integrated circuits. In this paper, we propose an integer convolutional neural network (CNN) implementation, Integer-Net, as a memory-efficient unified hardware-friendly CNN framework. The performance of Integer-Net is evaluated with multiple time-series data sets consisting of intracranial and scalp electroencephalogram (EEG) signals. Integer-Net shows a consistent seizure detection performance across three data sets: Freiburg Hospital intracranial EEG data set, Children’s Hospital of Boston-MIT scalp EEG data set, and UPenn and Mayo Clinic’s seizure detection data set. Our experimental results show that a 4-bit Integer-Net leads to only 2 drop of accuracy compared with a 32-bit real-value resolution CNN model, while offering more than 7 times improvement in memory efficiency. We discuss the structure of the integer convolution to improve the computational gain and reduce the inference time that are crucial for real-time application.
@cite_10: Epilepsy is a chronic neurological condition that affects approximately 70 million people worldwide. Characterised by sudden bursts of excess electricity in the brain, manifesting as seizures, epilepsy is still not well understood when compared with other neurological disorders. Seizures often happen unexpectedly and attempting to predict them has been a research topic for the last 30 years. Electroencephalograms have been integral to these studies, as the recordings that they produce can capture the brain’s electrical signals. The diagnosis of epilepsy is usually made by a neurologist, but can be difficult to make in the early stages. Supporting para-clinical evidence obtained from magnetic resonance imaging and electroencephalography may enable clinicians to make a diagnosis of epilepsy and instigate treatment earlier. However, electroencephalogram capture and interpretation is time consuming and can be expensive due to the need for trained specialists to perform the interpretation. Automated detection of correlates of seizure activity generalised across different regions of the brain and across multiple subjects may be a solution. This paper explores this idea further and presents a supervised machine learning approach that classifies seizure and non-seizure records using an open dataset containing 342 records (171 seizures and 171 non-seizures). Our approach posits a new method for generalising seizure detection across different subjects without prior knowledge about the focal point of seizures. Our results show an improvement on existing studies with 88 for sensitivity, 88 for specificity and 93 for the area under the curve, with a 12 global error, using the k-NN classifier.
@cite_11: 
Seizure nonseizure classification distinguishes seizure segments from nonseizure segments, which can be used to detect whether a data segment contains a seizure or not. For this task, extensive studies have been performed. Because seizure detection, which is often of a real-time flavor, is often treated as the seizure nonseizure classification problem, many machine learning methods have been developed @cite_1 @cite_15 @cite_7 @cite_11 @cite_5 @cite_10 @cite_13 @cite_22 @cite_9 . Recently, deep learning techniques have been applied to the seizure detection problem @cite_26 @cite_16 @cite_28 @cite_17 @cite_14 @cite_18 @cite_21 .