It will be the 30-year-old's first competition of 2016 as she prepares to defend her Olympic title in Brazil.
The double world champion missed the indoor season with an Achilles injury.
Ennis-Hill is not yet ready for a full heptathlon and will miss an event in Gotzis, Austria on 28 May.
Olympic heptathlon champion Jessica Ennis-Hill will begin the build-up to Rio 2016 by competing in the javelin at the Loughborough International Athletics match on Sunday.