Hooker Dylan Hartley and locks Christian Day and James Craig all come in to the Saints starting line-up.
Billy Vunipola makes his first appearance of the season for Saracens after recovering from a knee injury he suffered at the World Cup with England.
Brad Barritt, Richard Wigglesworth and Chris Wyles come into the back line.
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Hooker Schalk Brits makes his 150th appearance for Sarries while Mako Vunipola and Jacques Burger also come into the pack.
Argentine World Cup pair Juan Figallo and Marcelo Bosch are named as replacements.
Northampton: Foden; Elliott, G Pisi, Burrell, North; Myler, Fotuali'i; Waller, Hartley, Brookes, Craig, Day, Gibson, Wood (capt), Dickinson.
Replacements: Haywood, Waller, Hill, Patterson, Harrison, Dickson, Hanrahan, Tuala.
Saracens: Goode; Ashton, Taylor, Barritt, Wyles; Farrell, Wigglesworth; M. Vunipola, Brits, Du Plessis, Kruis, Hargreaves (capt), Itoje, Burger, B. Vunipola.
Replacements: George, Barrington, Figallo, Rhodes, Brown, Spencer, Hodgson, Bosch.
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Northampton wing George North will make his first Saints appearance of the season following his time at the World Cup with Wales.