The Swansea boxer's chance comes at Bethnal Green's York Hall on Saturday, 24 February.
Harris' father Peter was a British champion and Harris, who trains with Gary Lockett, is looking to follow in his footsteps.
"To be fighting for a title in just my 10th fight is huge for me," he said.
"I'm determined to become the Commonwealth champion."
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Welsh boxer Jay Harris will challenge Thomas Essomba for the Commonwealth flyweight title in just his 10th professional fight.