Eighteen people were arrested during the four-day operation and 63 vehicles were seized.
Forty-two of the vehicles had no insurance and/or licence.
A further 21 had no Vehicle Excise Licence, the Hampshire and Thames Valley operation discovered.
Hampshire Constabulary and Thames Valley Police said the joint operation earlier this month aimed to make the roads safer for people living and working in the region.
The "large quantity" of the substance believed to be cocaine was discovered in a car in the Iver and Denham area, officers said.
Other items seized included a stolen digger worth £12,000.
The lorry driver asleep in his cab was in a vehicle "piggy-backing" another vehicle in Portsmouth.
Both drivers were given fines totalling £1,000.
A lorry driver asleep at the wheel and a car thought to be carrying £100,000 of cocaine were among the discoveries made during a police crackdown on motoring offences.