Kneen, 28, won both Superbike events on his way to collecting the man-of-the-meeting award two years ago, and will ride for the Mar-Train Yamaha outfit.
Ryan Farquhar takes in the 'big bike' events on his BMW Superstock and the Supertwins class on his KMR Kawasaki.
Malachi-Mitchell Thomas competes after taking a treble at the Mid Antrim 150.
The Bolton rider is joined in the Cookstown BE Racing team by Dubliner Derek Sheils, who won the feature event at Mid Antrim on 2 April on his 1000cc Suzuki.
Farquhar struggled with the stability and electronics on his Superstock machine at Mid Antrim but emerged the victor in the Supertwins and won the opening Superbike race over the 5.3-mile Tandragee circuit last year.
William Dunlop is set to campaign his Supersport 600cc Yamaha at the County Armagh meeting, with Republic of Ireland competitors Derek Sheils and Derek McGee also in the mix.
The meeting features a nine-race programme, with practicing on Friday and racing on Saturday.
Manxman Dan Kneen will be out to repeat the form he showed on his debut in 2014 when he takes part in this weekend's Tandragee 100 road races.