Read the team news for Saturday's matches below.
Kick-off 15:00 unless stated. All times GMT.
Manchester City v Chelsea (12:30)
Crystal Palace v Southampton
Stoke City v Burnley
Sunderland v Leicester City
Tottenham Hotspur v Swansea City
West Bromwich Albion v Watford
West Ham United v Arsenal (17:30)
Birmingham City v Barnsley
Blackburn Rovers v Huddersfield Town
Bristol City v Ipswich Town
Burton Albion v Rotherham United
Cardiff City v Brighton and Hove Albion
Fulham v Reading
Norwich City v Brentford
Sheffield Wednesday v Preston North End
Wigan Athletic v Derby County
Leeds United v Aston Villa (17:30)
Four of the Premier League's top five are in action on Saturday, while there is a packed programme in the Championship.