The rash or blisters may not appear until as late as 48 hours after exposure, so do not wait to do this. If you identify poison sumac and know you have been exposed, pour rubbing alcohol over the affected skin as soon as possible. Because the toxin, urushiol, will not fully dissolve in alcohol, using a paper towel or other solid material to rub the alcohol-soaked skin may be necessary to remove a significant amount of the toxin.Warning: the alcohol may temporarily make you more susceptible to further exposure, by removing the protective oils on your skin. Avoid areas where poisonous plants grow for the next 24 hours after applying alcohol, if possible.
A better alternative is using a good surfactant to bind the oils before they penetrate the dermis of the skin, Fels Naptha (old fashioned yellow soap available at a hardware store) or good ole Spic n Span, wash the affected areas well, scrub and rinse well. Repeat. Do not touch any affected clothing as the oil will remain on the surface and readily transfer to skin.
Wear disposable gloves during this process if your hands have not been exposed.
 Whether or not you applied alcohol, scrub the exposed area with lots of cold water. Do not use warm water because it will open your pores and make the exposure worse. You may also use soap, detergent, or specialized products such as Tecnu, but wash these off frequently so they do not dry on your skin along with any toxin they have picked up., If you develop blisters or a rash, you may take oral antihistamines to reduce the itching. You may also apply calamine, hydrocortisone lotions, or oatmeal baths for the same purpose.


If you develop large, oozing blisters, you may wish to visit a doctor for prescription-strength treatment.
Ooze from blisters does not contain the toxin, so it cannot spread the rash.
 If you suspect you inhaled poison sumac smoke, seek medical attention immediately even if symptoms have not developed. Other serious situations that may require a doctor's attention include a rash on your face or genitals, or a rash anywhere that fails to reduce in size after a week, as well as eyes that are swollen shut, or trouble breathing., If you leave the sumac oil on tools or clothing, they can spread the rash for months or years after the initial exposure. Put on disposable gloves and wash tools with soap and water, rubbing alcohol, or diluted bleach. Store clothes in disposable bags during transport, then wash them in soap and hot water.
Consider using a towel soaked in rubbing alcohol immediately after exposure.
Wash in cold water.
Treat the rash with antihistamines or lotions.
Seek medical attention in severe cases.
Wash exposed tools and clothing.
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