What is the fine-grained topic of the following text: In this connection a series of substituted quinolinyl chalcones and substituted quinolinyl pyrimidines were synthesised and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV and antimalarial activity against NF-54 strain of Plasmodium falciparum. Only return the topic.
Synthesis and evaluation of substituted quinolinyl chalcones and pyrimidines for antitubercular and antimalarial activity.