What is the fine-grained topic of the following text: The review article: "The Enigma of Spontaneous Preterm Birth", publishes February 11, 2010 by the New England Journal of Medicine (NEJM), concludes that inflammation plays a major role in preterm childbirth and suggests researching how (quote) "...host-microbe interactions shape the immune response, possibly increasing or decreasing the likelihood that an inflammatory response will be directed against the fetus..." (end quote). Only return the topic.
The role of inflammation in spontaneous preterm birth.