What is the fine-grained topic of the following text: Now, in a further attempt to produce complexes that combine the antitrypanosomal activities of both the metal and ligand, researchers at the Universidade de São Paulo, Brazil, Universidad de la República, Uruguay, and Universidad Nacional de La Plata and Instituto IFLP, Argentina, have synthesised new Ru(II) complexes (2). Only return the topic.
Synthesis of new Ru(II) complexes for antitrypanosomal activities by international researchers