What is the fine-grained topic of the following text: Clinical risk endpoints (CRE) linked to the development of smoking-related disease were analyzed following a six-month randomized, controlled clinical study with THS, which demonstrated a consistent improvement of CREs in different pathophysiologic pathways leading to atherosclerosis. Only return the topic.
Analysis of Clinical Risk Endpoints in a Smoking-Related Disease Study using a Six-Month Randomized, Controlled Study with THS