What is the fine-grained topic of the following text: This must be done cautiously, however, because the movie shows many of the adverse effects and limitations of levodopa that occurred with rapid dose increases in Sacks’ patients with postencephalitic Parkinson disease much earlier than with our usual slow dose increases in patients with slowly degenerative Parkinson disease. Only return the topic.
Adverse effects and limitations of levodopa in treating Parkinson disease