What is the fine-grained topic of the following text: Seventeen dogs with HER2/Neu+ OSA that had undergone amputation and carboplatin chemotherapy received 1 × 108, 5 × 108, 1 × 109 or 3 × 109 CFU of ADXS31-164 intravenously every 3 weeks for three administrations. Only return the topic.
Treatment of HER2/Neu+ OSA in dogs with ADXS31-164 after amputation and chemotherapy.