What is the fine-grained topic of the following text: The combination of advanced scientific knowledge with evil impulses is the subject of both James B. Stewart’s Blind Eye: The Terrifying Story of a Doctor Who Got Away with Murder, and Deborah Blum’s The Poisoner’s Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York. Only return the topic.
Combination of advanced scientific knowledge with evil impulses in literature