What is the fine-grained topic of the following text: I found that energy levels are diminished in a high-cholesterol diet model for Alzheimer's disease in rabbit, a trisomic mouse model for Down syndrome (Ts65Dn), and following administration of Tat to primary mouse cortical cultures as a model for HIV-1 dementia. Only return the topic.
Impact of different diets and substances on energy levels in various disease models