What is the fine-grained topic of the following text: Several different inhibitors of BACE1 have been tested in clinical trials for Alzheimer’s disease, but the new study suggests that using 3K3A-APC to block the production of BACE1 could be an alternative approach, particularly at early stages of the disease when amyloid-beta has yet to accumulate to levels capable of permanently damaging the brain. Only return the topic.
Using 3K3A-APC to block BACE1 production as a potential treatment for early stages of Alzheimer's disease