What is the fine-grained topic of the following text: However, given the mode of action of SGLT2 blockers, initiation of a therapy with a SGLT2 blocker will cause an increase of creatine because of its effects on the tubuloglomerular feedback mechanisms/glomerular hemodynamics like RAAS blocking agents do. Only return the topic.
Effects of SGLT2 blockers on tubuloglomerular feedback mechanisms/glomerular hemodynamics.