What is the fine-grained topic of the following text: Preliminary analysis of the market opportunity for a DMOAD with clinically relevant impact on disease progression, an acceptable safety profile, and a market entry in the 2014 timeframe points toward an incremental global revenue forecast of $1 to 2 billion at peak penetration. Only return the topic.
Market opportunity analysis for a DMOAD (Disease-Modifying Osteoarthritis Drug) with a 2014 entry timeframe.