What is the fine-grained topic of the following text: The aim of this project is to develop an in silico tumour genome and transcriptome simulation tool and use this to a) model the effects of tumour evolution on emergent ITH, and b) benchmark current methods for delineation of ITH. Only return the topic.
Development and use of an in silico tumor genome and transcriptome simulation tool to study tumor evolution and Intratumor Heterogeneity (ITH).