What is the fine-grained topic of the following text: The MDD course worsened linearly with age; the worst outcomes were seen for people aged 70 years and older compared with those of the reference group aged 18 to 29 years (MDD diagnosis: odds ratio, 2.02; chronic symptom course, odds ratio, 3.19; time to remission: hazard ratio, 0.60; and depression severity change: −12.64 and −5.57 in those aged 18 to 29 and 70 years or older, respectively). Only return the topic.
The influence of age on Major Depressive Disorder (MDD) course and outcomes.