What is the fine-grained topic of the following text: CAPE and propolis, cause an accumulation of acetylated histone proteins in MCF-7 (ER+) and MDA-MB-231 (ER-/PR-/Her2-) cells with associated decreases in ER and PR in MCF-7 cells, and upregulation of ER and decrease in EGFR in MDA-231 cells. Only return the topic.
The effects of CAPE and propolis on acetylated histone proteins and hormone receptors in MCF-7 and MDA-MB-231 cells.