What is the fine-grained topic of the following text: Our goals are:(i) study the lack of association between the mutations and the patients clinical phenotype by differentiating COQ-iPSC towards disease-affected tissues (purkinje neurons and skeletal muscle), and (ii) characterize the metabolic dysfunction of iPSC and the differentiated progeny to assess whether exogenous CoQ10 rescues metabolic homeostasis and influences differentiation of COQ-iPSC. Only return the topic.
Studying the relationship between mutations, clinical phenotype, and metabolic dysfunction in COQ-iPSC, and assessing the effect of exogenous CoQ10 on metabolic homeostasis and differentiation.