What is the fine-grained topic of the following text: As opposed to direct treatment using NO-donating compounds, priming sensitivity of soluble guanylate cyclase (sGC) to NO may provide more efficacious therapeutic benefits as sGC stimulators work synergistically with endogenous NO to amplify cGMP production. Only return the topic.
Priming sensitivity of soluble guanylate cyclase (sGC) to NO for therapeutic benefits