What is the fine-grained topic of the following text: very often (< 1%), on that point crataegus laevigata be an inheriteddefect in alkali metabolism, which should be suspectedparticularly if gouty arthritis expands under time of life 25, in patientswith excretory product back breaker excretory organ calculi, or if in that respect is a efficacious familyhistory of early-onset gout. Only return the topic.
Inherited defect in alkali metabolism and early-onset gout