What is the fine-grained topic of the following text: The role transition structures (TSs) and vectors have played in discussing issues associated to enzyme catalysis is examined with focus on RubisCO; computations belong to standard semi-classic Born-Oppenheimer model with one-electron orbitals located at nuclear position coordinates. Only return the topic.
The role of transition structures and vectors in enzyme catalysis, with a focus on RubisCO and computations based on the Born-Oppenheimer model.