ObjectivesTo assess the skeletal status in asthmatic children treated with inhaled corticosteroids in a longitudinal observation by quantitative ultrasound (US) measurement at the hand phalanges. MethodsThirty-four children were studied prospectively. Quantitative US measurements were performed at baseline and after a meanSD of 2.350.20 years. The obtained results were compared to age-, sex-, and body size-matched control participants selected from a database of previously examined healthy children. Individual changes in the amplitude-dependent speed of sound (Ad-SoS) during the follow-up period were also analyzed. ResultsThe mean age of the asthmatic children was 10.6 +/- 2.5 years. The mean Ad-SoS in the asthmatic children at baseline was 1940.5 +/- 49.6 m/s, and the mean Z score was -0.26 +/- 0.80. Corresponding values at the follow-up examination were 1976.2 +/- 63.6 m/s and -0.18 +/- 1.16. The results did not differ significantly in comparison to the healthy controls. The analysis of individual changes in Ad-SoS revealed that 18 participants had a significant increase in this parameter (ie, exceeding the least significant change threshold), and 16 did not have a significant change in their values. No one had a significant decrease in Ad-SoS. ConclusionsQuantitative US at the hand phalanges applied as a diagnostic tool revealed no essential differences in the pattern of skeletal development between asthmatic children treated with inhaled glucocorticosteroids and healthy controls.