The north-western part of Bangladesh especially the Barind region is considered as a drought-prone area. The objective of this paper is to find out the adaptation measures practised by farmers to cope with climate change and agricultural drought in two drought-prone villages of the north-western Bangladesh. The primary data for this study were collected from a structured questionnaire survey conducted on 130 households selected from 192 through simple random sampling. The present study finds that agriculture of this area is recurrently disrupted by frequent drought events. Moreover, the climate change will increase both frequency and magnitude of extreme drought events in this region. This paper identifies that the impacts of drought on agriculture are difficulties in irrigation, disruption in cropping pattern, depletion of ground water table, problem in fish cultivation and so on. On the other hand, analyses unveil that respondents practised a range of adjustment strategies to combat adverse impacts of drought such as adoptions of drought-tolerant crop varieties, rainwater harvesting, mango and jujube intercropping with rice, kitchen gardening, weed control and reducing water loss, constructing water control structures, irrigation and cultivation of fast-growing fish species. Therefore, the present study recommends proper drought early warning system, reserving surface water, managing supplemental irrigation, tree plantation, re-excavation of canals and traditional ponds, credit support to the farmers, preparedness and awareness rising to ensure the future sustainable agricultural development in the study areas.