Introduction It is important to understand the interactions, processes, and issues that occur within telerehabilitation interventions to inform research and practice. The aim of this study was to identify the difficulties reported and intervention features that were captured as helpful in the notes written by occupational therapists during a telerehabilitation trial. Method Administrative documentation in the form of 60 subjective, objective, assessment, and plan notes were collected. The trial examined the effectiveness of three teleconference-delivered interventions: physical activity alone, fatigue management with physical activity, and contact-control social support for people with multiple sclerosis. Results Five themes emerged: desiring change, taking action, experiencing difficulty, infrastructure support, and relief and appreciation. Desiring change captured therapists' observations of clients' desire to manage symptoms and improve participation; it was most apparent at the beginning and supported clients' taking action as the interventions progressed. Therapists identified their own difficulties with group facilitation and time management and clients' difficulties with some intervention materials. Infrastructure support was reported to be helpful in minimizing some of these difficulties. In the end, the therapists expressed relief that the clients appeared to benefit from and appreciate the interventions. Conclusion This study highlights the need for and importance of providing resources and training to support teleconference-delivered interventions in clinical practice.