Under the background of "pubic entrepreneurship, people innovation", in order to speed up the implementation of innovation driven development strategy, it is imperative to deepen the innovation of colleges and universities entrepreneurship education reform. After "one system with multivariate" training mode reform, the comprehensive ability of the students of machine design manufacture and automation professional was promoted and the school innovation system of campus culture innovation reform was strengthened. In the long run it can effectively improve the quality of graduates and graduate employment competitiveness of colleges and universities. Aiming at the problems in the process of implementing the author puts forward some countermeasures and Suggestions.