Introduction: The association between primary monosymptomatic nocturnal enuresis (PMNE) and behavioral disorders was highlighted frequently, suggesting psychiatric origin. On the other hand, there is no difference between the incidence of mental disorders in children with PMNE and controls, although the psychological genesis could provide additional secondary forms, in which the child might react to stressful events with the resumption of involuntary urination at night, with a possible alteration of bowel control due to a high vulnerability to stressors. The purpose of this study is assessing the stressful events of life in a sample of children with PMNE. Materials and methods: 56 subjects with PMNE, (37 males and 19 females) (mean 10.87 years; SD +/- 1.68) were recruited consecutively. All subjects were evaluated for the presence of stressful events (ICU) with test Coddington Life Events Scales (CLES). The control group consists of 98 typically developing children (65 males, 33 females) (p = 0.855) (mean 11.3 years; SD +/- 1.85; p = 0.594). Results: Individuals with enuresis do not show a significant difference in the prevalence of stressful events than the control group (42.85% vs 41.83%; Chi-square = 0.002; p = 0,963) (table 1). Conclusions: These results for the first time show that PMNE can be regarded as an independent state by stress factors, suggesting that it itself represents a stress factor that can affect the proper psychological and neuropsychological development in children.