The purpose of this study was to investigate the logotherapeutic model as described by Frankl that explains the relationships among the search for meaning in life, the presence of meaning in life, existential vacuum, existential frustration, noogenic neurosis, will-to-power, and will-to-pleasure. A sample of college students from a large Mid-Atlantic university (N = 750) completed paper-and-pencil instruments for the variables. Structural equation modeling was used to test and compare four competing alternative models of the relationships among the aforementioned constructs. Two models exhibited excellent fit, one model good fit, and the fourth model poor fit. Of the two best models, one treated will-to-power and will-to-pleasure as outcomes of noogenic neurosis and the other treated them as causes of noogenic neurosis. Limitations, suggestions for future research, and implications for clinical practice are also discussed.