Poly(N-isopropylacrylamide) (NIPAAm) is well known as a smart material with good thermal sensitivity and favorable biocompatibility. A series of new smart hydrogels, NIPAAm copolymerized with IAM (itaconamic acid; 4-amino-2-methylene-4-oxobutanoic acid), were synthesized through radical solution polymerization in this work. Poly(NIPAAm-co-IAM) can respond to the changes of temperature as well as pH value. Such a characteristic is due to the fact that IAM contains not only a hydrophilic acrylic acid moiety but also an acrylamide moiety to be thermal and pH sensitive. The experimental results show that the lower critical solution temperature (LCST) of the copolymer increases as the molar fraction of IAM increases. Moreover, based on the current experimental data, 3 wt % of Poly(NIPAAm-co-IAM) aqueous solution in this study exhibits a phase transition temperature (37.8 degrees C) close to the human body temperature in the buffer solution of pH 7 possibly to be useful in drug delivery. (C) 2015 Wiley Periodicals, Inc.