PurposeThe occurrence of pressure ulcers (PrUs) challenges care facilities. Few studies report PrU reduction efforts in long-term acute care (LTAC). This study described the PrU reduction efforts of a single, LTAC facility using the Medline Pressure Ulcer Prevention Program (mPUPP). DesignThis study was a quasi-experimental, quality improvement project, with pre- and postmeasurement design. MethodsOutcomes were tracked for 24months. The mPUPP was implemented in month 11. Education for caregivers was provided through an interactive web-based suite. In addition, all Patient Care Technicians attended a 4-week 1-hour inservice. New skin care products were implemented. The facility also implemented an algorithm for treatment of wounds. FindingsThere was a significant reduction in the mean monthly hospital-acquired PrU (nPrU) rate when preprogram is compared to postprogram. ConclusionsSustainable nPrU reduction can be achieved with mPUPP. Clinical RelevanceLTAC hospitals could expect to reduce nPrU with education and incentive of caregivers.