Soil salinization is one of the most common land desertification processes that can be found worldwide. It is a certainly severe environment hazard and threatens the stability of ecosystems. As a rapid and inexpensive tool, remote sensing technology combining with the measurements of soil spectra has been widely concerned on identifying and mapping salt effect on lands. However, as effects of the soil moisture often immerge the effects of salt to soil reflectance spectra, soil moisture became a major factor to restrict soil salinity monitoring from soil reflectance. High soil moisture content will lead to failure on soil salinity estimation from soil reflectance data. In this paper, a semianalytical model using an exponent function was developed to estimate soil salt content (SSC) under different moisture levels based on a control laboratory experiment. And the root-mean- square error and mean relative error were 0.799 g/kg and 31.294%, respectively, when the model was applied to estimate SSCs by wet soil reflectance. To sum up, considering both effects of soil moisture and soil salt on soil reflectance, the semianalytical model reduced SSC estimated error. The approach presented in this paper provides a new way of estimating soil salinity from soil spectra under various soil moisture conditions, and it will be a potential application for large-scale SSC mapping.