Memristor is a nano device that exhibits unique IV pinched hysteresis loop with switching mechanism and has ability to remember its last state. These interesting memristor characteristics encourage researchers to understand the new device and develop its potential applications. The problem is memristor has not yet available in current market due to the cost and technical difficulties in fabrication nanoscale device. Thus, the only way is develop model for memristor. In this paper, few SPICE memristor models are selected and their I-V behaviors are compared to a physical memristor to verify model similarity with actual device. Next a new approach of CMOS memristor application is proposed. An interfacing circuit between SPICE memristor model and CMOS circuit is presented. The interfacing circuit is composed by write circuit (to program memristor resistance) and read circuit (to read memristor current) using operational amplifier and current mirror. This interfacing circuit is very important to incorporate memristor into CMOS for CMOS-memristor application studies.