Research on men's health has increasingly recognized the importance of depression and eating disorders among men. The present study sought to extend extant work on self-concept and depression to men, incorporating muscularity-related attitudes and behaviors, and also incorporating risk for disordered eating. Two samples, one of 204 heterosexual college men and one of 197 gay and bisexual men sampled online, were recruited. Participants completed measures of drive for muscularity, self-concept, depression symptoms, and eating disorder symptoms. Data were analyzed using a structural equation model in which the relationships between drive for muscularity attitudes and behaviors, and depression and eating disorder symptoms, were mediated by physical self-concept, global physical self-concept, and selfesteem. The model was supported for the gay and bisexual men sample, but not for the college men sample. Implications for future research with men, and integration of body-related variables into therapy with men, are discussed.