Objective. The aim of this study was evaluate the effects of resistance exercise on bone markers in HD patients. Material and methods. Twenty-six patients undergoing hemodialysis were assigned to either an exercise group (EG n=14) or a control group (CG n=12). The EG performed approximately six months of intradiatytic resistance exercise program (using elastic bands and leggings with both lower limbs) monitored thrice weekly (72 sessions), while the CG received standard care. Plasma bone markers (osteoprotegerin OPG, osteocalcin OC, Osteopontin OPN and intact parathyroid hormone-iPTH) were measured by Luminex. Results. OPG levels increased significantly after resistance training in EG (from 6.8 +/- 1.8 to 7.8 +/- 1.8 ng/L, P=0.02), whereas OC, OPN and iPTH did not change. Conclusion. In summary, resistance exercise may have contributed to the increase in OPG plasma levels and probably to the prevention of bone loss among HD patients who participated in the exercise program. (C) 2017 Elsevier Masson SAS. All rights reserved.