Objectives: Two genome-wide association studies (GWAS) have identified the IL-23 receptor- IL-12 receptor beta 2 (1L23R-IL12RB2) as the susceptibility genetic region in Turkish and Japanese population with Behcet's disease (BD). We investigated the association of this region with BD in a Northern Chinese Han population. Methods: A total of 407 patients with BD and 421 healthy controls were genotyped for single nucleotide polymorphisms (SNPs) rs924080 and rs11209032 using the Sequenom MassArray system. Results: Statistically significant associations with BD were detected at two SNPs namely, rs924080 and rs11209032, both, by allele analysis (OR = 1.58, 95% CI = 1.25-2.00, P-c = 2.52 x 10(-4), and OR =1.45, 95% CI = 1.19-1.76, P-c = 3.46 x 10(-4), respectively), and genotype analysis (P-c = 1.22 x 10(-3) and P-c = 1.77 x 10(-3), respectively). Significant differences were observed in the genotype frequency distribution for these SNPs under the additive, dominant and recessive models (all P-c < 0.05). The haplotypes (AT and GC) formed by the two SNPs were associated with BD (all permutation P < 0.05). A meta-analysis also appeared to support the association of the two SNPs with BD. Conclusion: SNPs (rs924080 and rs11209032) of the IL23R-IL12RB2 region were found to be associated with BD in a Northern Chinese Han population. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.