In the present work, hydrodynamics and mass-transfer performance of vapor-liquid flow of orthogonal wave tray (OWT) column was studied. Dry pressure drop, operating range (capacity graph) and overall column efficiency of OWT column were investigated using pilot columns. A three-dimensional CFD model was developed within the two-phase Eulerian framework to have an insight into the two-phase flow and mass-transfer behavior of OWT. The simulated results were compared with experimental data and showed a good agreement. Hydrodynamic and mass-transfer behaviors were revealed with the aid of velocity profiles, streamlines, interfacial area density distribution and so on. The effects of vapor/liquid load (F-s factor) on the Murphree tray efficiency were also studied. The simulations of OWT with different waves showed that the pressure drop, clear liquid height, froth height and Murphree tray efficiency increase with the increase of slope, and OWT with middle slope tended to have more uniform foam layer. Comparison of the liquid-phase component velocity between OWT and ripple shows that OWT has better performance in froth layer distribution and stability. The mass-transfer data showed that OWT not only had almost the same "peak efficiency" as sieve tray, but also had higher capacity and stability, it was suitable for capacity expansion. (c) 2016 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.