Aims and objectives. To identify factors associated with anxiety and depression of patients with implantable cardioverter defibrillators. Background. Implantable cardioverter defibrillator is effective to increase survival from life-threatening arrhythmias, but it lowers health-related quality of life. Anxiety and depression had significant negative association with health-related quality of life. However, knowledge about factors associated with these two negative emotions in this specific population is inadequate. Design. A cross-sectional descriptive design was conducted. Secondary analysis was performed to address the aim. Methods. A convenience sampling of patients with implantable cardioverter defibrillators was performed. Anxiety and depression were measured by the Hospital Anxiety and Depression Scale through face-to-face interview. Results. Stepwise multivariable regression results showed that older age (aged 60-69 and >= 70: B = 2.08 and 3.31, p = 0.039 and= aged 60) and more self-care dependent perceive higher depression. Nursing strategies are suggested to reduce depression especially for those who are older people and more self-care dependent. Early screening is essential to provide immediate care for reducing vulnerabilities arising from depression. Performing comprehensive assessment for selfcare ability and providing adequate assistance are crucial. Family involvement may reduce depression through providing physical and psychosocial support.