This study investigates the retention load (RL) between ZrO2 primary crowns and secondary polyetheretherketone (PEEK) crowns made by different fabrication methods with three different tapers. Standardized primary ZrO2 crowns were fabricated with three different tapers: 0 degrees, 1 degrees, and 2 degrees (n = 10/group). Ten secondary crowns were fabricated (i) milled from breCam BioHPP blanks (PM); (ii) pressed from industrially fabricated PEEK pellets (PP) (BioHPP Pellet); or (iii) pressed from granular PEEK (PG) (BioHPP Granulat). One calibrated operator adjusted all crowns. In total, the RL of 90 secondary crowns were measured in pull-off tests at 50 mm/min, and each specimen was tested 20 times. Two- and one-way ANOVAs followed by a Scheff's post-hoc test were used for data analysis (p < 0.05). Within crowns with a 0 degrees taper, the PP group showed significantly higher retention load values compared with the other groups. Among the 1 degrees taper, the PM group presented significantly lower retention loads than the PP group. However, the pressing type had no impact on the results. Within the 2 degrees taper, the fabrication method had no influence on the RL. Within the PM group, the 2 degrees taper showed significantly higher retention load compared with the 1 ffi taper. The taper with 0 degrees was in the same range value as the 1 degrees and 2 degrees tapers. No impact of the taper on the retention value was observed between the PP groups. Within the PG groups, the 0 ffi taper presented significantly lower RL than the 1 degrees taper, whereas the 2 degrees taper showed no differences. The fabrication method of the secondary PEEK crowns and taper angles showed no consistent effect within all tested groups.