In the "Design4All" project, a hardware and software architecture is under development for the implementation of adaptable and adaptive applications aimed to support all people in carrying out an independent life at home. In this paper, the problems of interactions with applications implemented in the Android platform, chosen for the experiments of interaction with the developed applications, are discussed with main emphasis on two main aspects: (i) the use of facilities supporting accessibility available in the most commonly used operating systems (mainstreaming) and (ii) the portability of solutions across different platforms.