In this paper, we conduct research on differences of Uighur Han Chinese communication etiquette customs and the psychological characteristics under cross-cultural environment. Empathy is the process of cross-cultural communication subject and adapts to each other and good a better means of communication. In cross-cultural communication, we must improve on the sensitivity of the taboo, taboo customs of different peoples and nations. In this way can eliminate communication barriers and conflict, to achieve smooth with the harmonious language communication. This article will use the theory of intercultural communication with the understanding of the Uygur traditional culture as can dissolve the contradictions and obstacles of the communication. This article from two aspects of the language communication, nonverbal communication in the process of cross-cultural communication problems enumerated and analyzed which will be meaningful.