Objective: Weight restoration in anorexia nervosa (AN) is associated with lower relapse risk; however rate of weight gain and percent of patients achieving weight restoration (BMI >= 19 at discharge) vary among treatment programs. We compared both cost/pound of weight gained and cost of weight restoration in a hospital-based inpatient (IP)-partial hospitalization (PH) eating disorders program to estimates of these costs for residential treatment. Method: All adult first admissions to the IP-PH program with AN (N5314) from 2003 to 2015 were included. Cost of care was based on hospital charges, rates of weight gain, and weight restoration data. Results were compared with residential treatment costs extracted from a national insurance claims database and published weight gain data. Results: Average charge/day in the IP-PH program was $ 2295 for IP and $ 1567 for PH, yielding an average cost/pound gained of $ 4089 and $ 7050, respectively, with 70% of patients achieving weight restoration. Based on published mean weight gain data and conservative cost/day estimates, residential treatment is associated with higher cost/pound, and both higher cost and lower likelihood of weight restoration for most patients. Discussion: The key metrics used in this study are recommended for comparing the costeffectiveness of intensive treatment programs for patients with AN.