OBJECTIVE: To explore the correlation between plasma beta 2-microglobulin (beta 2-MG) as senescence factor with age, heart, liver and kidney function as well as the predictive value of beta 2-MG in human metabolism function and senescence. PATIENTS AND METHODS: 387 cases of healthy people of different ages were selected and the automatic biochemical analyzer was used to test beta 2-MG in plasma based on immuno-turbidimetry and also all biochemical indexes. The correlation between beta 2-MG and age, gender and all biochemical indexes was analyzed. RESULTS: beta 2-MG was positively correlated to age, r = 0.373; and the difference was of statistical significance (p < 0.010). It was significantly negative correlated to HDL-C but positively correlated to LP (a), BUN, CREA, UA, CYS-C, LDH, CK-MB, HBDH, AST, GLB and HCY. CONCLUSIONS: beta 2-MG was closely correlated to age, heart, kidney and liver biochemical indexes, which can be taken as an important biomarker for human body function and anti-senescence and have significant basic research and clinical guidance values.