With the continuous development of higher education enterprise and improvement of scientific research conditions, the quality and quantity of large instruments and equipment in colleges and universities have been greatly improved. However, the problem of low efficiency of high quality resources has not been well solved. Problems existed in the construction, management, and utilization of open sharing system of large instruments in colleges are found. In allusion to these problems, the corresponding solutions are doped out. More importantly, it can be used as reference in construction of the opening sharing system of large instruments in other colleges. The practice of opening sharing system of large instruments promotes effective utilization of technological resources in colleges. Making use of advanced technology, intensive operation, humanized service, and networked management will be significant in the construction of a better open sharing system of large instruments in colleges. This paper, taking Harbin Institute of Technology as an example, summarizes the process of its construction of sharing platform of large precise instruments, analyzes the problems in such construction, and eventually finds out some measures to construct the open sharing system of large instruments in colleges.