Youth sports participation is on the rise, resulting in an increase in sports-related injuries in the pediatric and adolescent population. The presentation of injury, pathology, and disease in this younger population is often unique and may require customize and novel medical and rehabilitation interventions to optimize the outcome. The purpose of this review is to highlight unique considerations in the rehabilitation management of the pediatric and adolescent athlete. General guidelines for progression of this population through a criteria-based rehabilitation program with a focus on a systematic return to sport algorithm will be reviewed.