Introduction: Irritable Bowel Syndrome (IBS), a common gastrointestinal (GI) disorder has been linked with asthma implying a clue to its pathophysiology as being some form of allergic response. Previous studies from other parts of the world have shown both the presence as well as an absence of an association between them. Aim: We conducted a cross-sectional study to find an association between IBS and asthma, in an Indian cohort. Materials and Methods: Seventy patients of IBS diagnosed by exclusion and ROME III criteria with a matched control group were questioned for GI, respiratory symptoms along with their Medicine Section spirometry analysis. Those having reversible bronchoconstriction were categorized as asthmatic. Results: The prevalence of asthma in the IBS group of 16 females and 54 males was 12 (17.14%) as compared to 14 (20%) in control group. Chi-square test revealed the Odds Ratio (OR) for prevalence of asthma in IBS as 0.828 with 95% Confidence Interval (CI) between 0.320 and 2.121 (p=0.664) which was nonsignificant (p>0.05). Conclusion: This study denies the presence of association between IBS and asthma among Indian cohorts and suggests that regional variations are present in the above association.