Structural health monitoring is a key factor in life cycle management of infrastructures. Truly distributed fiber optic sensors are able to provide relevant information on large structures, such as bridges, dikes, nuclear power plants or nuclear waste disposal facilities. The sensing chain includes an optoelectronic unit and a sensing cable made of one or more optical fibers. A new instrument based on Optical Frequency Domain Reflectometry (OFDR), enables to perform temperature and strain measurements with a centimeter scale spatial resolution over hundred of meters and with a level of precision equal to 1 mu strain and 0.1 degrees C. Several sensing cables are designed with different materials targeting to last for decades in a concrete aggressive environment and to ensure an optimal transfer of temperature and strain from the concrete matrix to the optical fiber. Tests were carried out by embedding various sensing cables into plain concrete specimens and representative-scale reinforced concrete structural elements. Measurements were performed with an OFDR instrument; meanwhile, mechanical solicitations were imposed to the concrete element. Preliminary experiments are very promising since measurements performed with distributed sensing system are comparable to values obtained with conventional sensors used in civil engineering and with the Strength of Materials Modelling. Moreover, the distributed sensing system makes it possible to detect and localize cracks appearing in concrete during the mechanical loading.