The aim of the research is to examine the HIV risk factors affecting poor health in Ethiopia by epidemiological perspectives. The Demographic and Health Survey 2011 and other secondary data were used. Ethiopian population growth has slowed dramatically or stopped due to HIV and AIDS. A logistic regression and correlation between HIV positive towards AIDS, high risk factors leading to exposure to HIV infection was adopted with selected variables. The study confirmed that the high level of HIV positivity and poor health was highly affected by socio-economic and demographic factors.