Almost one of four Germans is registered in a sports club. Nowadays, sport is acknowledged as an integral component of a healthy lifestyle. Numerous studies provide evidence of the benefits of sports on health. However, about 2 million sports injuries per year diminish the health benefits of sport. (a) Description of the epidemiology of sports injuries in German sports club between 1987 and 2012 and (b) identification of focal areas for the development and implementation of prevention measures. Continuous questionnaire-based injury monitoring of club sports injuries that have been reported to the respective sports insurance. Full survey among selected federal sports associations. Since 1987, a sample of 200,884 sports injuries has been established. About two thirds of the injuries are reported in soccer, handball, basketball, and volleyball, although only one third of all sports club members are registered in these team sports. The number of women's soccer injuries has risen from 7.5 to 15.6 %. Ankle injuries have decreased from 28.7 to 16.9 %. By contrast, the rate of knee injuries has increased from 18.4 to 20.3 %. Days of disability have dropped steadily since the 1990s. Inpatient hospital days have decreased from 10 to 5 days, whereas the share of injuries that needed surgery increased from 30 to 40 %. Team ball sports are still a clear focal area for injury prevention, as participation and injury risk are highest in this group. While the prevention of ankle injuries seems to be headed in the right direction, knee injuries are increasing. As team ball sports become more popular among women, who are more prone to severe knee injuries, prevention programs should be tailored toward the specific situation and needs of the targeted sports participants.