Recently, the research on the co-cultural groups gradually becomes a new focus. In the midst, the study on the disabled co-culture is a typical example. Going from this perspective, this paper mainly summarizes the influence of physical appearance, interpersonal space and distance, and paralanguage etc. to the disabled and nondisabled people's communication and analyzes the cultural foundations based on Hofstede's theory of value orientations. Finally communication principles are proposed. The purpose is to improve the intercultural communication between the disabled and nondisabled people.