Floods impose a significant risk to buildings sustainability. Due to climate changes this issue becomes a topic for more and more areas. Among various categories, cultural heritage is especially vulnerable because its assets cannot be reproduced. This contribution discusses some results of the ongoing research project focused on protection of cultural heritage from flood danger. One of the crucial goals of the project is the design and development of a methodology and supporting software application for analysing building and materials vulnerability to floods. During the research several experts from various areas of materials engineering contributed to an extensive knowledge base covering the most important materials related to immovable constructs, and movable objects. The model has been designed with the goal to be transformed to a formalised computer model that enables development of a knowledge system. Such a system has been prototyped and it is now being finalized for end users. It offers the users to perform customised analysis of their building consisting of general aspects of the building and location together with sophisticated details of inner building constructions and movable objects.