The distribution of water pollution is often assessed by remote sensing. In this study, we develop a fuzzy multiple regression model and analyze water quality using data collected by the Advanced Visible and Near Infrared Radiometer type-2 (AVNIR-2) of the Advanced Land Observing Satellite at different time points. We conduct a fuzzy multiple regression analysis of the AVNIR-2 data and direct measurements of the local water quality of Lake Hachiroko in Japan. The relationship between the AVNIR-2 and water quality data are analyzed by solving both min and max problems. We compare the estimated water quality maps with the actual distributions in the study area, and determine that the proposed method enables us to derive water quality conditions effectively from the AVNIR-2 data. Furthermore, by comparing maps created using AVNIR-2 data collected at different times, we obtain results revealing temporal changes in water quality. In addition, we compare maps created using the fuzzy multiple regression and fuzzy regression models. We demonstrate that the former offers a greater number of solutions and provides more details about water quality.