Objective: To assemble and synthesize the best evidence oil the epidemiology, diagnosis, prognosis, treatment, and prevention of musculoskeletal injuries and pain in dancers. Data Sources: Medline, CINAHL, PsycINFO, Embase, and other electronic databases were searched from 1966 to 2004 L]Sin go key words such as dance, dancer, dancing, athletic injuries, occupational injuries, sprains and strains, and musculoskeletal diseases. In addition, the reference lists of relevant Studies were examined, specialized journals were hand-searched, and the websites of major dance associations were scanned for relevant information. Study Selection: Citations were screened for relevance using a priori criteria, and relevant Studies were critically reviewed for scientific merit by the best evidence synthesis method. After 1865 abstracts were screened, 103 articles were reviewed, and 32 (31%) of these were accepted as scientifically admissible (representing 29 unique studies). Data Extraction: Data from accepted Studies were abstracted into evidence tables relating to the prevalence and associated factors, incidence and risk factors, diagnosis, treatment, economic costs, and prevention of musculoskeletal injuries and pain in dancers. Data Synthesis: The scientifically admissible studies consisted of 15 (52%) cohort studies, 13 (45%) cross-sectional Studies, and 1 (3%) validation study of a diagnostic assessment tool. There is a high prevalence and incidence of lower extremity and back injuries, with Soft tissue and overuse injuries predominating. For example, lifetime prevalence estimates for injury in professional ballet dancers ranged between 40% and 84%, while the point prevalence of minor injury in a diverse group of university and professional ballet and modern dancers was 74%. Several potential risk factors for injury are suggested by the literature, but conclusive evidence for any of these is lacking. There is preliminary evidence that comprehensive injury prevention and management strategies may help decrease the incidence Of future injury. Conclusions: The dance medicine literature is young and heterogeneous, limiting our ability to draw consistent conclusions. Nonetheless, the best available evidence suggests that musculoskeletal injury is an important health issue for dancers at all skill levels. Better quality research is needed in this specialized area. Future research would benefit from clear and relevant research questions being addressed with appropriate study designs, use of conceptually valid and clinically meaningful case definitions Of injury and pain, and better reporting of studies in line with current scientific standards.