BACKGROUND The objective of this study is to overview the attempts of suicide in young females and its relation to PCOS and thyroid profile dysfunction. World health report puts that the yearly global prevalence of suicide attempt varies between 2% to 20%. 1 The incidence of attempted suicide is greatly influenced by the differences in age, sex, race, religion, culture, marital status, habitat, climate and social systems. 2 This study aimed to analyse risk factor, mode of attempt, and spectrum association with PCOS, thyroid dysfunction in young females. MATERIALS AND METHODS The present study was conducted in department of medicine with history of attempted suicides from March 2015 to May 2016 (100 cases). All female (15-49 years) subjects meeting the selection criteria were evaluated. RESULTS There were a total of 738 female patients admitted in the Emergency ward of our tertiary care centre during the study period of one and half years from 1st March 2015 till 31st May 2016. During this study period, 100 patients of attempt of suicide who were admitted to the Medical ICU of our tertiary care centre were studied. This resulted in a prevalence of 8.9%, and incidence of attempt of suicides were 96% cases of poisoning out of which 27% were unmarried and 69% were married females and the rest 4% by hanging with 2% each. Evaluation of hospitalised patients due to suicidal attempt showed PCOS in 14% cases and Hypothyroidism and Hyperthyroidism in 16% and 1% cases respectively. Among cases with Hypothyroidism, signs of depression were present in 81% cases (n=13) whereas 19% cases (n=3) had stress. Signs of frustration, anxiety, stress & depression were present in 7%, 7%, 29% and 57% cases respectively among those diagnosed to have PCOS. Overall, there were 58% cases of stress which led to suicidal attempt. CONCLUSION Present study revealed importance of hormonal changes which occur in PCOS, hypothyroidism and causes psychophysical changes in young and reproductively active females. An attempt is made to focus on all these issues so that in future we can intervene early and prevent complications.