The key to the success of surgical navigation based on computer-aided design and computer-aided manufacturing (CAD/CAM) planning is the registration process. This has to be precise and adapted to the surgical needs. However, the application of a conventional rigid skull-fixed navigation star for accurate registration is limited for use in the paediatric population, because of the risk of unstable fixation, dural perforation, and intracranial bleeding. The authors describe their experience with a non-invasive reference headband that was used in combination with a custom-made acrylic resin dental registration splint for resection of a rare infraorbital zygomatic desmoplastic fibroma in a 2-year old patient. This approach appears not to have been reported in the literature to date.