Background: The increasing prevalence of obesity has necessitated the increasing use of bariatric surgery in the adolescent population. Outcomes following laparoscopic sleeve gastrectomy (LSG) among adolescents, however, have not been well-studied. We report outcomes following LSG as a first-line surgical therapy in patients under 21 years of age. Methods: All patients who underwent LSG as a primary surgical option for morbid obesity were identified at the University of Illinois at Chicago between 2006 and 2014. Standard clinicopathologic and outcomes data were recorded. Results: We identified 18 patients (13 females, 5 males) who underwent LSG. Mean patient age was 17.8 +/- 1.7 years. Mean BMI among all patients was 48.6 +/- 7.2 kg/m(2) and did not differ by gender (P=0.68). One patient (5.6%) experienced a 30-day perioperative complication (pulmonary embolism). Median LOS following LSG was 3 days (IQR: 2, 3). 2 patients (11.1%) were readmittedwithin 30-days because of feeding intolerance that resolved without invasive intervention. At a median follow-up of 10.6 (range: 0-38) months, percent excess weight loss (% EWL) among all patients was 35.6%. Among patients with at least 2 years follow-up (n=3), % EWL was 50.2%. Conclusions: Laparoscopic sleeve gastrectomy in morbidly obese adolescents is a safe and feasible option. Short-and long-term weight loss appears to be successful following LSG. As such, LSG should be strongly considered as a primary surgical treatment option for all morbidly obese adolescents. (C) 2017 Elsevier Inc. All rights reserved.