Nowadays, the garment industries are developing from the traditional manufacture industry to the culture creative industry in China. The knowledge employees in garment industry are facing some new challenges and work stress from high requirements for organizational management which are needed at the current circumstance. The article indicated that the work stress of knowledge employees in garment industry has reached a middle-up level. The researched discovered different characteristics of work stress on the basis of demographic variables through empirical research. In order to adhere to the philosophy of people-oriented, the organization should strengthen work stress management, which has high value and importance not only for improving the human resource management but also for enhancing the potentiality of knowledge employees and expanding organization performance practically at the same time in the future.