This paper describes macromodeling of operational amplifiers for overdrive circuit design. Macromodels have been applied to operational amplifier simulations with good convergence. Also, macromodels allow the accurate simulation with not only double-power supply but also single-power supply. In this study, a macromodel has been applied to an overdrive circuit for sound effect design. Output waveform using the macromodel is compared with that using a pre-set model only with double-power supply and experiment. The output of the macromodel shows more accurate in amplitude, a frequency, and distortion than that of the pre-set model. From this result, the macromodel of the operational amplifier is suitable than the pre-set model in the overdrive circuit design.