Brazilian jiu-jitsu (BJJ) is a grappling combat sport that athletes, lying (guard fighter) or kneeling (pass fighter) on the mat, attempt to force their opponents to submit. Brazilian jiu-jitsu practices may result in muscular imbalances, which increase the risk of injury. Instead, the Functional Movement Screen (FMS) is an evaluation routine that could be related to injury incidence and seeks to detect muscular imbalance and movement dysfunction. Thus, the aim of the study was to investigate the injury profile and the FMS score and their relationship, with consideration for the BJJ fight style. Sports injuries were recorded in the last 12 months of 33 BJJ athletes, and the statistical analyses were applied to a routine evaluation FMS and a score of 14 points or less was considered low performance in FMS. We used a logistic regression; the effect size (ES) was calculated, and 5% was assumed as the statistical significance level. Pass fighters showed a higher percentage of injuries on the thorax (24.24%) than did guard fighters (6.67%, p = 0.01). Upper limbs were the most injured part of the body (chi(2) = 36.7; p < 0.001), and they were 79% of the injuries that occurred in training sessions (chi(2) = 14.53; p < 0.001). Despite the lack of statistical differences in the FMS performance between guard and pass fighters (t = 1.97; p = 0.05), its magnitude was considered medium (ES = 0.77). There was an association between FMS and presence of injury (chi(2) = 4.95; p = 0.03). Considering the FMS score as a predictor and the presence or absence of injury as the dependent variable, the data met a Wald coefficient of 4.55, p = 0.03 and Exp (B) = 5.71. The study found that almost half of the sample had injuries in the upper limbs and a quarter had injuries in the lower limbs in the last year. A poor FMS score was observed, and lower scores in the FMS were associated with a higher risk of injury in BJJ athletes.