The landscape of aesthetic dermatology has changed dramatically over the past couple of years due to soaring patient demands for minimally invasive, safe, effective, and fast whole-body procedures and the continuously emerging new technologies. Moreover, the concept of whole-body rejuvenation as the new paradigm that ensures skin health and age prophylaxis by stimulating dermal remodeling, epidermal turnover, skin tightening, and modulating repletion or depletion of volume requires clinical application of a combination of energy-based devices (intense-pulsed light, fractional lasers, vascular lasers, ultrasound, radio-frequency, shockwave, and low-energy laser light devices) alongside fillers/toxins and an at-home skin care regimen. This present-day reality has mobilized physicians to carefully assess the best strategies for their patient's goals while capitalizing on the advantages of each of the technologies entering the arena. As such, this report aims to provide an overview of the mainstream energy-based modalities currently used for whole-body rejuvenation.