Based on fuzzy decision theory, multi objective fuzzy optimization is done for the dynamic isolation model scheme of self-anchored cable-stayed suspension bridge. Using two comparison theory solves the problem of quantifying the qualitative indexes and distinguish the concepts of importance and superiority. Combining the fuzzy decision method with engineering practice and using the results of five cases are proposed for multi objective fuzzy optimization. Comparison results show that it is more reasonable to place lead rubber bearings not only between pier and girder, but also main tower and girder, with viscous dampers between main tower and girder on the same time. This method can provide a reference for structure selection in practical conceptual design phase.