Acacia Nilotica seed shell ash supported Ni0.5Zn0.5Fe2O4 magnetic nanoparticles were synthesized by a low-cost, simple, and environmentally benign procedure. The adsorbent was characterized by several methods including X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy. Then, the potential of Acacia Nilotica seed shell ash supported Ni0.5Zn0.5Fe2O4 magnetic nanoparticles was investigated for adsorption of Pb(II). The effect of different parameters including contact time, pH, adsorbent dosage and initial Pb(II) concentration on the Pb(II) removal yield was studied. The experimental data were fitted well with the pseudo-second order kinetic model (R-2 = 0.999). The adsorption isotherm was described well by the Langmuir isotherm (R-2 = 0.900) with a maximum monolayer adsorption capacity of 37.6 mg g(-1). The process for purifying water treatment presented here is easy using the magnetic nanoparticles. Therefore, this adsorbent was found to be useful and valuable for controlling water pollution due to Pb(II) ions.