Introduction: The use of beta emitters is one of the effective methods for palliation of bone metastasis. The risk of normal tissue toxicity should be evaluated in the bone pain palliation treatment. Methods: In this study, the Monte Carlo simulation code MCNPX was used for simulation a bone phantom model consisted of bone marrow, bone and soft tissue. Specific absorbed fractions were calculated for monoenergetic electrons, photons and eight beta emitters: P-32, Sr-89, Y-90, Sm-153, Ho-166, Lu-177, Re-186 and Re-188. Beta and gamma S-factor, absorbed dose and cumulative dose of mentioned radionuclides were obtained to the selection of radionuclides with optimal radiation characteristics. Results: The results show Lu-177 gives a higher local dose to source organ. Lu-177 has fewer side effects on critical organ including bone marrow in comparison with other radionuclides such as Sr-89, P-32 and Y-90. Cumulative dose versus time shows after a long time, long half-life radionuclides delivering a higher dose in comparison with the short-half radionuclides. Conclusion: According to the results, low energy beta-emitters(177)Lu, Sm-153 and Re-186 can be used for bone pain palliation especially in vertebra. Different combination of these radionuclides can be used to improving therapeutic effects for tumors with different size.