For increasing the efficiency of combustion engines new airpath concepts with increased complexity are viable. In case of gasoline engines one promising technology is two-stage turbocharging. The closed-loop control of such an airpath concept is investigated in this paper. In particular a modelbased predictive control approach is proposed. It reveals the advantage of taking the multiple input process behaviour into account, compensation for the arising deadtime and respecting the turbocharger speed limits, with low demands on the calibration effort. For validation the proposed control algorithm was implemented on a prototyping electronic control unit and tested in a vehicle. In the present paper the results of the vehicle experiments, conducted on a chassis dynamometer, are demonstrated.