Objective: Chronic periodontitis (CP) is associated with increased systemic inflammation and osteoporosis. Proinflammatory cytokines, implicated in systemic bone loss, are also associated with periodontitis. The impact of control of systemic inflammation by scaling and root planing (SRP) on bone mineral density (BMD) in postmenopausal (PM) osteopenic women with CP was investigated in this study. Method and Materials: Sixty-eight PM osteopenic women with CP were included. The test group (n = 34) received SRP along with calcium (500 mg) and vitamin D (250 IU) supplementation twice a day for 6 months, while the control group (n = 34) received calcium (500 mg) and vitamin D (250 IU) supplemen-tation twice a day for 6 months. BMD, serum high sensitivity C-reactive protein (hsCRP), and periodontal parameters were recorded at baseline and 6 months. Results: Improvement in BMD and serum hsCRP showed a statistically significant difference between groups at 6 months (P <.001). Binomial logistic regression analysis revealed that the test group was 4.82 (OR adjusted = 4.82; 95% CI = 1.17-19.71; P =.029) times more likely to exhibit normal BMD at 6 months. The results suggest there is an association of control of systemic inflammation by SRP with improved BMD in PM osteopenic women with generalized severe CP.