In the last two decades, computational hydraulics has undergone a rapid development following the advancement of data acquisition and computing technologies. Using a finite-volume Godunov-type hydrodynamic model, this work demonstrates the promise of modern high-performance computing technology to achieve real-time flood modeling at a regional scale. The software is implemented for high-performance heterogeneous computing using the OpenCL programming framework, and developed to support simulations across multiple GPUs using a domain decomposition technique and across multiple systems through an efficient implementation of the Message Passing Interface (MPI) standard. The software is applied for a convective storm induced flood event in Newcastle upon Tyne, demonstrating high computational performance across a GPU cluster, and good agreement against crowd-sourced observations. Issues relating to data availability, complex urban topography and differences in drainage capacity affect results for a small number of areas.