Objective: Present study was designed to find out whether leptin is a predictor of bone mass density (BMD) in premenopausal women (PMW) and postmenopausal osteoporotic women (PMOPW) or it has no association with BMD.Methods: One hundred and ninety two women (98 PMOPW and 94 PMW) were recruited for this study. The control group was BMI matched with osteoporotic subjects. BMD assessment was done on calcaneus by peripheral ultrasound bone densitometry and T scores were determined. Serum leptin levels were measured by enzyme-linked immunosorbent assay (ELISA).Results: Serum leptin and BMD values were significantly different in both groups (leptin, 18.568.65ng/ml versus 21.649.80ng/ml, p=0.02) and (BMD, -0.700.19 versus -3.170.59, p=0.000), respectively. In PMOPW serum leptin and BMD were considerably correlated with weight (lep, r=0.53, p=<0.001; BMD, r=-0.21, p=0.02), BMI (lep, r=0.52, p =<0.001; BMD, r=-0.27, p=0.005), waist circumference (lep, r=0.61, p=<0.001; BMD, r=0.18, p=0.04), hip circumference (lep, r=0.58, p=<0.001).Multivariate linear stepwise regression analysis showed that weight and BMI in PMW and PMOPW were independent predictors of BMD. Serum leptin level was not found to be the predictor of BMD in both groups.Conclusion: The present results indicate that body weight and BMI have an impact on BMD while serum leptin is not associated with BMD in PMW and PMOPW.