By taking the Runyang Highway Bridge over the Yangtze River with 1490 m main span as example, structural response of the bridge under the horizontal and vertical seismic excitations is investigated by the response spectrum and time-history analysis of MIDAS/Civil software respectively, the seismic behavior and the influence of structural nonlinearity on the seismic response of the bridge are revealed. Considering the aspect of seismic performance, the suitability of employing the suspension bridge in super long-span bridges is investigated as compared to the cable-stayed bridge and cable-stayed-suspension hybrid bridge with the similar main span. Furthermore, the effects of structural parameters including the span arrangement, the cable sag to span ratio, the side to main span ratio, the girder height, the central buckle and the girder support system etc on the seismic performance of the bridge are investigated by the seismic response spectrum analysis, and the favorable earthquake-resistant structural system of suspension bridges is also discussed.