The objective of self modeling curve resolution (SMCR) methods is to decompose a second-order bilinear data matrix into a range of chemically meaningful matrices without any knowledge about the chemical or physical model describing the considered system. In addition, SMCR methods are efficient approaches to deeply investigate data structures by finding not only one of the solutions but all possible ones. Multi-set data analysis can be a powerful tool to decrease the range of feasible solutions in the absence of appropriate conditions for unique resolution. Using SMCR methods, we have investigated the impact of multi set data analysis on the accuracy of soft modeling results. Interestingly, the feasible regions of individual and simultaneous analysis are compared in a common abstract space. It is demonstrated how such global analysis can result in the reduction of rotational ambiguity in soft modeling analysis. Moreover, as a systematic study, different factors are considered in order to discover the advantages and limitations of multi-set data analysis and lead to a proper design for more accurate results. (C) 2016 Elsevier B.V. All rights reserved.