By sharing rows and columns, the 2-D networked resistive sensor arrays simplified the interconnect complexity but suffered from the crosstalk problem among its elements. The crosstalk was mainly affected by the multiplexers' resistor, adjacent column elements, adjacent row elements, and array size. First, we designed an improved isolated drive feedback circuit (IIDFC) using one operational amplifier to reduce the crosstalk caused by the adjacent column elements in the 2-D networked resistive sensor array. Then, a mathematical equivalent resistance expression of the element being tested (EBT) for this circuit was analytically derived. Then, the IIDFC and its equivalent resistance expression of the EBT were evaluated by the simulations. The simulation results show that the IIDFC can greatly reduce the crosstalk error caused by the adjacent column elements in the 2-D networked resistive sensor array with the row-column fashion and its resistance expression of the EBT can be used as a general formula to evaluate the performance of the IIDFC.