This article explores the illicit labor and imprisonment of two women, Cynthia and Dinah, in the Santa Monica prison in Lima, Peru through the lens of gendered motherwork. Because the unequal distribution of care places the burden of this labor on women, Cynthia and Dinah were primarily responsible for the care of their adult children who were diagnosed with AIDS. Both women entered the transnational cocaine commodity chain in order to provide their children with medication that was not administered by the state. Neoliberal healthcare in the form of cuts to national health systems makes the motherwork of poor women more difficult to perform. In order to afford care for their children's health, Cynthia and Dinah entered a labor market that is criminalized by punitive war on drug policies and they were subsequently imprisoned. Illicit labor was therefore an extension of their motherwork and the removal of this care from their children resulted in tragic health consequences. This article is based on ethnographic dissertation fieldwork in 2008-09 in the largest women's prison in Peru.