Recent studies showed that a large amount of graphene oxide accumulated in kidney and liver when it injected intravenously. Evaluation of lethal and apoptosis gene expression in these tissues, which are under stress is very important. In this paper the in vivo dose-dependent effects of graphene oxide and reduced graphene oxide nanoplatelets on kidney and liver of mice were studied. Balb/C mice were treated by 20 mg/kg body weight of nanoplatelets. Molecular biology analysis showed that graphene nanoplatelets injected intravenously lead to overexpression of BAX gene in both kidney and liver tissues (P >= 0.01). In addition these nanoparticles significantly increase BCL2 gene expression in both kidney and liver tissues (P >= 0.05). Graphene significantly increase level of SGPT in groups 1 (220.64 +/- 13), 2 (164.44 +/- 9.3) in comparison to control group (P <= 0.05). Also in comparison with control group (148.11 +/- 10.4), (P <= 0.05), the level of SGOT in groups 1(182,01 +/- 12.6) and 2 (1782 +/- 22) significantly increased. (C) 2016 Published by Elsevier B.V.