Volcanosedimentary boron deposits are formed in specific volcano and lake facies deposition environment in Neogene period, and the characteristic of the boron bearing stratum is the containing boron lacustrine sedimentary rocks and tuff and andesite volcanic rocks interbedded cyclically and composed binary sedimentary structure. As the borate mineral deposition occurred in the late deposition period, usually associated with tuff and clay and limestone, so the formed boron deposits had the characteristics of low density, low electrical resistivity. According to the characteristic of the boron deposits, we employ comprehensive geophysical technology in the exploration. We firstly conducted the 1 : 50000 high-precision gravity survey in the Xiongba area, Tibet, and obtain the Bouguer gravity anomalies. Through the processing and analysis of the gravity data, we got access to the fault structures development and gravity anomaly changes in the study area, deduced the spatial variation characteristics of underground lithology and delineated the favorable mining area of volcanosedimentary boron deposits; based on that, the 1 :5000 audio magnetotelluric sounding is carried out on the favorable area and the electrical structure characteristics of the underground strata in the study area are obtained. Combining the seismic-electric fitting of the electrical data, the joint inversion of gravity and electricity data and the geological data in the study area, we further analyzed stratum structure, fracture system and the distribution of sedimentary rocks and their relation to the volcanosedimentary boron deposits. Then we predicted the distribution of the volcanosedimentary boron deposits, the drilling test results are basically consistent with the predicted results.