College is a critical time in which individuals experience transition and stress, and may experience subthreshold or clinical symptoms of anxiety and depression. In addition, educational contexts offer a unique opportunity to serve the needs of a diverse group of students who may experience additional stressors related to experiences with discrimination; acculturative stress; financial strain; and balancing family, work, and school demands. Therefore, college appears to be an ideal time for students to learn about evidence-based skills to use in response to anxiety and depression. However, there are multiple barriers that may make it less likely that evidence-based skills and services are available to or utilized by students, including lack of funding and services available on campus, as well as concerns about mental health stigma. This study examines the preliminary acceptability and effectiveness of an acceptance-based behavioral stress/anxiety management workshop for university students on a diverse urban campus. Results indicate that participants found the workshop to be acceptable and helpful. Mixed-effect regression models examining symptom and impairment measures at preworkshop, 1-week follow-up, and 4-week follow-up showed a significant effect for time on anxious arousal, general anxiety symptoms, and social anxiety, but no significant effect for time on impairment. Implications and future directions for mindfulness and acceptance-based approaches in educational contexts are discussed.