The biological resistance of different preservatives and mechanical properties of particleboard have a key role in panel performance. The attack ability of Microcerotermes diversus and Anacanthotermes vagans termites to particleboard evaluated and also, mechanical properties of particleboards measured. The alkaline copper quat (ACQ), boron-fluorine-chromium-arsenic (BFCA salts) and Chlorotalonil (CTL) were used to particleboard protection against termite. Degradation grading the termite attack was performed in accordance with the ASTM D 1758-06 specifications. This research was conducted in Sistan region for 18 months in field condition. Both weight loss and grading values indicated that the particleboard has the most degradation when exposed to Anacanthotermes vagans termite. The biological resistance of CTL-treated particleboard and control sample is the same. Treated specimens with BFCA and ACQ have a high biological resistance against the Microcerotermes diversus and Anacanthotermes vagans termites (5.5 and 13 percent weight losses, respectively). The weak mechanical strength such as internal bond is related to BFCA-treated particleboard (0.49 Mpa). ACQ-treated particleboard strength (0.74 Mpa) is similar to control sample (0.76 Mpa) and the highest strength value (1.25 Mpa) was obtained for particleboard made from CTL. In general, ACQ-treated particleboard indicated better performance than others particleboard. (C) 2017 Elsevier Ltd. All rights reserved.