Larger displacement and inter-force response of the structure will be produced when self-anchored cable-stayed suspension bridge in longitudinal earthquake. The optimized layout of viscous damper is done for self-anchored cable-stayed suspension bridge with the lead rubber bearings in the main tower, moreover, the nonlinear time-history analysis in the longitudinal seismic input be made. Comparing the analysis results above between the scheme with viscous damper and the scheme without isolation measures, analysis results show that inter-force and displacement of control section and control node are reduced greatly in hybrid vibration control.