Thermodynamics dependent microstructure, phase, and physical model predictions of material characteristics are demonstrated for aluminum alloys 7020 (Al-4.5Zn-1.2Mg), 7039 (Al-4.0Zn-2.8Mg), and 7075 (Al-5.6Zn-2.5Mg-1.6Cu) by application of Sente Software's* Java Materials Program (JMatPro), mesoscale computation materials engineering software. JMatPro reveals phase constitutions as a function of input composition, temperature, and time and, using material property databases and physical models, calculates temperature-dependent physical and mechanical properties. With secondary application, the elastic bulk moduli for constituent phases and inclusions, derived from Gibbs energy by JMatPro, are used to predict the maximum levels of microscale shear stresses under hydrostatic pressure. With comparison to conditions known to cause incipient spall in 7020 alloy, levels of microscale shear stress around inclusions are shown to equal or exceed the level of Von Mises calculated shear yield strength.