This study describes the conceptual design and the first prototype implementation of the Multi-Sense CardioPatch, a wearable multi-sensor patch for remote heart monitoring aimed at providing a more detailed and comprehensive heart status diagnostics. The system integrates multiple sensors in a single patch for detection of both electrical (electrocardiogram, ECG) and mechanical (heart sounds, HS) cardiac activity, in addition to physical activity (PA). The prototypal system also comprises a microcontroller board with a radio communication unit and it is powered by a Li-Ion rechargeable battery. Results from preliminary evaluations on healthy subjects have shown that the prototype can successfully measure electromechanical cardiac activity, providing useful cardiac indexes. The system has potential to improve remote monitoring of cardiac function in chronically diseased patients undergoing home-based cardiac rehabilitation programs.