Objective: The aim of this study was to identify the prevalence of metabolic syndrome (MetS) and degree of cardiovascular disease (CVD) risk in patients with psoriatic arthritis (PsA). Material and Methods: We performed a cross-sectional study on 102 adult patients with PsA and a control group of 102 patients with rheumatoid arthritis (RA). MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF) criteria. The Framingham risk scores of 10-year risk of CVDs and coronary heart disease (CHD) were also calculated. Results: The prevalence of MetS was higher in patients with PsA than in those with RA, according to the NCEP-ATP III (40.6% vs. 24.7%, respectively; p= 0.019) and IDF (46.8% vs. 27.9%, respectively; p= 0.05) criteria. The prevalence of MetS was higher in female patients with PsA (p= 0.009) than in male patients. A significantly increased prevalence of hypertriglyceridemia was determined in patients with PsA (p= 0.019). No significant difference existed between the two groups with respect to 10-year CVD (p= 0.333) and CHD (p= 0.798) risks. Additionally, there were no significant differences between the clinical subtypes of PsA with regard to MetS (p= 0.229). Conclusion: MetS prevalence increased in patients with PsA compared with those with RA, whereas the risks were similar for CVDs and CHD. For this reason, optimal protection measures should be taken and guidelines should be applied to achieve adequate metabolic control in patients with PsA.