Introduction: Depression is a frequent disorder characterized by the presence of sadness, loss of interest or pleasure in everyday activities, guilt feelings, low self-esteem, sleeping or eating disorders, feeling of tiredness and lack of concentration. Patient's satisfaction with his/her prescribed treatment is defined as "patient's evaluation on the administration of his/her treatment and the results obtained". The aim of the present study is to assess satisfaction with the prescribed antidepressant treatment (considering type of medication, dosage and length of treatment) through a validated questionnaire to evaluate patients' satisfaction. Patients could ask for it in three pharmacies located in different provinces of Argentina. Method: A descriptive observational cross-sectional study was carried out during January and February 2015. A satisfaction survey was given to patients over 18 years old who were taking any antidepressant medication and wanted to answer it. Results: 262 patients answered the survey. Selective serotonin reuptake inhibitors (SSRIs) were the most commonly prescribed antidepressants: paroxetine, fluoxetine and sertraline with an average dose of 19,2mg/day, 21 mg/day and 37mg/day respectively. Sixty-eight percent of the patients were taking antidepressants for the first time. Fifty-one percent had treatment from seven to twenty-four months. After the satisfaction assessment of those who completed the survey, it was generally observed that 90.5% considered the treatment was efficient. Conclusions: We conclude that patient satisfaction with the antidepressant treatment is high; the most common one is with SSRI, on daily morning doses for at least one year, at recommended doses.