Attack of angioedema is a frequently occurring disorder, especially in adults. It may appear with or without hives and itch. It may be idiopathic or it may accompany other disorders. They may be allergic, including IgE-related, in which histamine is the major mediator, or non-Ige-related, mediated by other mediators, e.g., PAF. Allergic angioedema is provoked by food, insect venom, drug, or allergic focal infection. They very often go with an itching and hives. Corticosteroids, antihistaminics and adrenalin are drugs effectively removing their symptoms. The nonallergic angioedema, in contrast to allergic one, is usually induced by bradykinin. This type of angioedema grows slowly. It is not accompanied by itch and hives and it can reach large size. It disappears spontaneously after 2-3 days. Bradykinin mediated angioedema is a consequence of hereditary or acquired deficiency of C1 inhibitor or hyperactivity of agglutination factor XII. It can appear also after intake of some drugs that decrease inactivation of bradykinin. It is resistant for corticosteroids, antihistaminic drugs or adrenaline and requires treatment with C1 inhibitor drugs or inhibitor of B2 receptor of bradykinin, or fresh frozen plasma. Bradykinin angioedema presents as subcutaneous external angioedema or in submucosal membrane of internal organs (usually of the airways or the digestive system). Bradykinin angioedema of the airways may be fatal and requires immediate efficient medical treatment. However, bradykinin angioedema of the digestive system also may be dangerous due to shock provoked by hypovolemy and ache, or due to intestine occlusion.