Long-span suspension bridges have evolved through the years and with them, the bridge girder decks improved as well, changing their shapes from standard box-deck girders to twin box and multi-box decks sections. The aerodynamic characteristics of the new generation of twin and multiple-decks are investigated nowadays, to provide the best design wind speeds and the optimum dimensions such bridges could achieve. The multi-box Megane bridge deck is one of the new generation bridge decks, consisting of two side decks for traffic lanes and two middle decks for railways, linked between them with connecting beams. Three-dimensional CFD simulations were performed by employing the Large Eddy Simulation (LES) algorithm with a standard Smagorinsky subgrid-scale model, for Re = 9.3 x 10(7) and angles of attack alpha = -4 degrees, -2 degrees, 0 degrees, 2 degrees and 4 degrees. Also, a wind tunnel experiment was performed for a scaled model, 1:80 of the Megane bridge deck section, for Re = 5.1 x 10(5) and the aerodynamic static coefficients were found to be in good agreement with the results obtained from the CFD-LES model. However the aerodynamic coefficients determined individually, from the CFD-LES model, for each of the traffic and railway decks of the Megane bridge, varied significantly, especially for the downstream traffic deck. Also the pressure distribution and the effect of the spacing between the connecting beams, on the wind speed profiles showed a slight increase in turbulence above the downstream traffic and railway decks.