BACKGROUND For many years, 'conventional' double contrast enteroclysis has been suggested as the technique of choice for the evaluation of the small intestine. Computed tomography (CT) performed with oral and intravenous contrast material has a proven track record of depicting bowel wall and mesenteric abnormalities. CT enteroclysis was developed to overcome the individual deficiencies of CT and conventional enteroclysis and to combine the advantages of both barium enteroclysis and conventional abdominal CT examinations into one technique. The present study is a longitudinal study to evaluate the role of multi-detector row helical Computed Tomographic (CT) enteroclysis for the depiction of small bowel diseases in patients. Aim of Study-To prospectively evaluate the role of multi-detector row helical Computed Tomographic (MDCT) enteroclysis for the depiction of small-bowel diseases. MATERIALS AND METHODS Study Group-CT enteroclysis was done for 35 clinically suspected cases of small-bowel diseases referred to Department of Radiodiagnosis, Yenepoya Medical College, Mangalore from October 2014 to September 2016. RESULTS Of the 33 patients who underwent successful CT enteroclysis, positive findings were obtained in 16 patients (48.5%), and negative findings were obtained in 17 patients 51.56%). Among the 16 patients, CT enteroclysis allowed the detection of small-bowel masses in 4 patients including 2 Adenocarcinoma, 1 gastrointestinal stromal tumour and 1 lymphoma. CT enteroclysis demonstrated metastatic lymph nodes in 2 cases; small-bowel abnormalities in 12 patients including 4 patients with Crohn's disease and 2 patients with small-bowel tuberculosis. Images demonstrated site and cause of small bowel obstruction in 2 cases and areas of stenosis in 12 cases with the mural and extramural inflammatory changes. CONCLUSION CT enteroclysis is a fast, well-tolerated, and reliable imaging modality for the depiction of small-bowel diseases. This technique provides adequate small-bowel distension in a majority of patients. In addition, CT enteroclysis allows the detection of extraluminal disease and provides information relative to the entire abdomen that is not obtained with small-bowel follow-through or endoscopy.