High school students in a chemistry course were challenged to prepare an improved lemon cake by means of statistical experimental design. They were introduced to basic statistical experimental design theory, calculation of effects, empirical mathematical models, response surfaces and their isocontour projections, as well as descriptive statistics. Geogebra, a digital program for teaching and learning mathematics, was used to produce the mathematical models and response surface plots. Assessment of the lemon cakes with regard to fluffiness (texture), lemon taste, and an overall rating required efficient planning of sensory panels. A slight extrapolation, that is, selection of the experimental setting outside the investigated domain, and assessment of the predicted procedure to check the reproducibility of the lemon cake recipe were also included in this project, which complements the Next Generation Science Standard.