The issue of novelty-seeking traits have been related to important economic attitudes such as risk-taking, entrepreneurial, and explorative behaviors that foster technological progress and, thus, economic development. However, numerous molecular genetic studies have shown that novelty-seeking bearing individuals are prone to certain psychological "disadvantages" such as Attention Deficit Hyperactivity Disorder (ADHD), leading to occupational and educational difficulties in modern societies. Using a recent compilation of DRD4 exon III allele frequencies a particular gene variant that population geneticists have found to be sometimes associated with the human phenotype of novelty-seeking behavior-this paper advances a new country-level measure on the prevalence of novelty-seeking traits for a large number of countries worldwide. The results suggest a stable non monotonic inverted U-shaped relationship between the country-level DRD4 exon III allele frequency measure and economic development. This finding is suggestive of the potential "benefits" and "costs" of novelty-seeking traits for the aggregate economy.