The number of decease due to Cardiovascular Disease (CVD) in low and middle-income countries has become a major concern. From a clinical standpoint, electrocardiogram is an useful mechanism to diagnose cardiac diseases. Therefore, electrocardiogram based machine design has taken into consideration to create a framework for building a simple, low cost microcontroller based ECG monitoring system. However, most of the machines in current research has high price with bulky shape which deprives the people of remote area to get benefit from it. Therefore, the paper tries to design a smart economical diagnosis system which can maintain reliable diagnosis with better portability. This system has been implemented by instrumentation amplifier with high common mode rejection ration and right leg circuit to remove 50 Hz noise of ac main. Digital and analog filtering of the system has optimized the signal by removing baseline wandering and power frequency noise. The communication between the hardware and software is interfaced through USB port using microcontroller. The implementation of this system shows greater benefits in domestic health monitoring and rural area's medical camp.