Recently, number of smart material are investigated and widely used in civil construction and other industries. Present study investigates the application of smart semi-active piezoelectric friction damper (PFD) made with piezoelectric material for the seismic control of the horizontally curved bridge isolated with lead rubber bearing (LRB). The main aim of the study is to investigate the effectiveness of hybrid system and to find out the optimum parameters of PFD for seismic control of the curved bridge. The selected curved bridge is a continuous three-span concrete box girder supported on pier and rigid abutment. The PFD is located between the deck and abutments or piers in chord and radial directions. The bridge is excited with four different earthquake ground motions with all three components (i.e. two horizontal and a vertical) having different characteristics. It is observed that the use of semi-active PFD with LRB is quite effective in controlling the response of the curved bridge as compared with passive system. The incorporation of the smart damper requiring small amount of energy in addition with an isolation system can be used for effective control the curved bridge against the dynamic loading.