The Quality Function Deployment (QFD) model and the optimal decision-making model is applied to the design of special-shaped stone Machining Center. Through the establishment of Design of house of quality of Machining Center, it can convert the users' needs and requirements of improvement on machining center into engineering measures of shape design of machining center in manufacturing engineering and at the same time combine resource consumption of various engineering measures implemented and resources of enterprises together. In the constrains of limited resource, in order to make the design of machining center meet the customers' needs to the maximum extent and enhance the competitiveness of machine tool in the market, the optimal decision model can be used to select the vital engineering measurement on re-designing machining tool.