The wind tunnel test of large-scale sectional model and computational fluid dynamics (CFD) are employed for the purpose of studying the aerodynamic appendices and mechanism on suppression for the vortex-induced vibration (VIV). This paper takes the HongKong-Zhuhai-Macao Bridge as an example to conduct the wind tunnel test of large-scale sectional model. The results of wind tunnel test show that it is the crash barrier that induces the vertical VIV. CFD numerical simulation results show that the distance between the curb and crash barrier is not long enough to accelerate the flow velocity between them, resulting in an approximate stagnation region forming behind those two, where the continuous vortex-shedding occurs, giving rise to the vertical VIV in the end. According to the above, 3 types of wind fairing (trapezoidal, airfoil and smaller airfoil) are proposed to accelerate the flow velocity between the crash barrier and curb in order to avoid the continuous vortex-shedding. Both of the CFD numerical simulation and the velocity field measurement show that the flow velocity of all the measuring points in case of the section with airfoil wind fairing, can be increased greatly compared to the results of original section, and the energy is reduced considerably at the natural frequency, indicating that the wind fairing do accelerate the flow velocity behind the crash barrier. Wind tunnel tests in case of the sections with three different countermeasures mentioned above are conducted and the results compared with the original section show that all the three different countermeasures can be used to control VIV to varying degrees.