Aspergillosis of face affects the nose and eyes mainly. The invasive and in particular, the fulminant forms are associated with high mortality. We report a case of sino-orbital aspergillosis in a known case of diabetes mellitus. The Patient underwent surgery for debridement of right maxillary sinus through transnasal approach. Successful treatment of aspergillosis requires prompt diagnosis and institution of therapy, because delay or non aggressive therapy can result in spread in infection and lethal consequences.