Nowadays securing data has become a prime concern for educational institutes, workplaces etc. USB drives are now largely used for storing and transferring data due to its large capacity at nominal cost, high-transferring rate and portability. These drives are not only used to store data but they also have the ability to run software programs and boot the operating systems. Besides several advantages, USB drives are being misused for stealing data and injecting viruses, Trojans and malicious software into the system. With the invent of U3 technology, which runs based on the auto-run facility of the operating system it has become possible to copy data without the owner's knowledge. This paper provides a solution to safeguard from data-thefts without using physical methods like using superglue to block the USB ports, without altering the registry values and without using Bios method.