Traumatic ankle injury is a frequent clinical presentation. Ankle taping is commonly used in the prophylaxis of sprains and as an adjunct during rehabilitation of ankle injury. The mechanisms behind taping remain unclear however, one possible mechanism is improved proprioception and peroneal reflex responses. This study investigated the peroneal reflex response to rapid inversion (using a trapdoor) with different taping protocols. The dominant leg of 31 healthy subjects was tested in three conditions: no taping; simple prophylactic taping; and circumferential leg taping. A repeated measures ANOVA revealed no statistically significant effect across conditions or trials. The results suggest that neurophysiological responses to sudden inversion are not altered by mechanical or sensory input from taping in normal subjects.