Computer aided materials design is of increasingly importance and interest because the conventional approach solely relying on experimentation is no longer viable within the constraint of available resources. The CALPHAD approach, which emerged first as an approach for the calculation of phase equilibria and thermodynamic properties of complex multi-component, multi-phase systems, has in recent years been applied to a broader field of materials science and engineering beyond phase diagrams, such as solidification, coating, joining, and phase transformation. This approach, therefore, plays an important role in modern materials design in the framework of Integrated Computational Materials Engineering. In this study, we present a modeling approach that integrates thermodynamic calculation and kinetic simulation to simulate the precipitation kinetics of multi-component alloys. Its applications will be demonstrated by the studies of a number of nickel-based alloys.