Objective: To evaluate the relationship between the serum resistin levels and metabolic syndrome (MetS) in chronic spontaneous urticaria (CSU) patients. Methods: In the study 42 CSU patients and 42 healthy volunteers were included. Height, weight, waist circumference, and blood pressure measurements were assesed for both of the groups. Fasting blood sugar, serum lipid levels, resistin and tumor necrosis factor-alpha (TNF-alpha) levels were evaluated in the venous blood samples. The metabolic syndrome (MetS) diagnosis was determined using the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria. Results: MetS was found in 14 (33.3%) CSU patients and 5 (11.9%) control subjects. There was a statistically significant difference between the two groups (p=0.037) in terms of MetS presence. It was found that the mean serum resistin levels was 1928.31 +/- 212.85 pg/mL in the CSU patients and 2107.60 +/- 156.71 pg/mL in the control group. There was no statistically significant difference between the groups in terms of serum resistin levels. No difference was seen between the patients with and without a diagnosis of MetS regarding the urticaria activity score, duration of the disease, autologous serum skin test positivity, serum immunoglobulin E levels, presence of autoimmunity, serum resistin and TNF-alpha levels. Conclusion: An increased incidence of MetS in the CSU patient group is found in our study. However, there was no difference between the CSU patients with and without MetS regarding the disorder-associated parameters and the serum resistin and TNF-alpha levels.