We review selected aspects of the interactions between protein and energy in human metabolism and nutrition. Following a short account of the underlying metabolic basis for the effects of energy on protein metabolism, the contribution made by whole body protein turnover to the metabolic rate is discussed, including the relationship between protein turnover and energy metabolism at different phases of life. The effects of changes in energy metabolism and intake on the nitrogen economy of the host are also reviewed briefly and we explore the relationship between amino acid oxidation and requirements for indispensable amino acids. Interactions between energy and protein metabolism need to be investigated in greater detail and also they must be considered in relation to further attempts to establish more precisely energy and amino acid requirements of people under various circumstances.