There are conditions in dermatology that cause severe cracking and flaking of the skin, representing a failure of normal desquamation. Several hygroscopic substances that affect the moisturization of the stratum corneum have been identified for the treatment of scaling disorders. Prominent among these are polyols and alpha hydroxy acids. We elaborated a new pharmaceutical product that combines the biomolecules glycerol and ammonium lactate. The aim of this study was to evaluate the physicochemical stability and rheologic properties of the new skin care preparation.