Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied.Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR=1.63, 95%CI=1.03-2.58, p=0.04). The association was not significant among men.Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.Conclusion: Accumulation of CML may be an adverse health consequence of SDB