A new sandwich structure which core is made of thin-walled semi-ellipsoidal shell is designed, column cell sandwich composite was prepared by pre-panel preparation process. A series of quasi-static axial compression experiments were carried out on 2 x 2 thin-walled semi-ellipsoidal shell, the compression deformation and yield behavior of thin wall semi-ellipsoidal shells with different materials, diameters and wall thicknesses were studied by means of ANSYS/LS-DYNA finite element simulation and experiment. Then, the effect of filling mode of epoxy resin on the mechanical properties of Column-cell sandwich composites was studied. The results show that the deformation process of the thin spherical shell can be divided into local flattening, axisymmetric depression, non-axisymmetric depression and compaction stage. As the wall thickness increases, the deformation"mode changes from the polygon to the ring and the deformation process become three stages; small diameter requires larger force under the conditions of the same compression displacement, as the diameter increases, the critical displacement of flipping and asymmetric buckling increases; Epoxy filled in the spherical shell of the sample specific compression performance is better than filled in the outer shell and better than unfilled with epoxy resin. (C) 2017 Elsevier B.V. All rights reserved.