Predicting grain growth in nanocrystalline materials requires modeling approaches that incorporate grain boundary thermodynamics and kinetics. In this work, the thermokinetic model of Chen et al. (2012) for grain growth was applied to experimental X-ray diffraction measurements from a binary nanocrystalline alloy in an effort (1) to understand the influence of thermodynamic, kinetic, and material parameters in the model; and (2) to extend the thermokinetic model by incorporating temperature dependence. The model performs well for the grain boundary saturated case in the binary nanocrystalline alloy, where it is assumed that solute segregates to the grain boundaries and thermodynamically/kinetically reduces the driving force for grain growth. In this work, a sensitivity analysis of parameters (Monte Carlo global sensitivity analysis) identifies the important thermodynamic/kinetic parameters and their correlation with one another for the present model. This model was then extended to include the change in these independent thermodynamic/kinetic parameters as a function of temperature and to model the effect of initial grain size distribution. This research shows that the thermodynamic and kinetic contributions can describe grain growth in nanocrystalline materials and this extended model can be parameterized for grain size evolution and stabilization with temperature for nanocrystalline systems. Published by Elsevier B.V.