Temporary closures of polluted coastal waters to shellfish harvesting protect human health but also generate broad socioeconomic impacts on rural, fishing-dependent communities. Improved understanding of these impacts could help coastal managers prioritize investments to protect water quality and mitigate the effects of coastal pollution. Using a regression model of monthly landings, we explore the impact of temporary closures on the commercial harvest of soft-shell clams (Mya arenaria) in the Machias Bay region of Maine (USA). We find that economic losses are significant and depend heavily on tidal activity, and the size, frequency and timing of closures. Over the nine-year sample period (2001 2009), temporary pollution closures contributed to the loss of 33.6 million in forgone revenue (2014 dollars), approximately 27.4% of total revenue. Closures linked to combined sewer overflows from the Machias wastewater system produce the majority of these losses ($2.0 million) with the largest occurring during the peak clamming season (May August). Our results highlight the variability of the impacts of closures and the information burden for efficient management of shellfish areas and coastal waters. By strategically reducing pollution, managers could limit public health risks, avoid destabilizing harvesting and revenue, and bolster the resilience of fishing communities. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).