The third-person effect (TPE) hypothesis states that people typically perceive the media messages to have greater influence on others than on themselves. Though this self-other perceptual bias has been shown to be robust across a variety of message contexts, past research has typically utilized Caucasian college student samples. The current study addresses this shortcoming in the literature by examining whether the TPE hypothesis holds for low-income, low-education, Spanish-speaking female adults with regard to the perceived effects of health news coverage. Our findings showed that most participants chose "equal to others" when estimating health news effects on themselves instead of "less than others" or "more than others." Results from ordinal logistic regression showed that the propensity toward TPE was related to optimistic bias and certain indicators of acculturation. Our findings suggest the need for future TPE research in Hispanic populations and further efforts to investigate TPE from an intercultural perspective.