OBJECTIVE: To determine the frequency of thyroid dysfunction in patients with menstrual disturbances. PATIENTS AND METHODS: This multidisciplinary case series study of six months was conducted from Jan 2016 to June 2016 at LUMHS Jamshoro Sindh Pakistan. All the ladies with menstrual disturbances were evaluated for thyroid dysfunction by screen their serum fT3, fT4 and TSH level. The data was collected and analyzed in SPSS 16 while the frequency and percentages (%) was calculated. RESULTS: Total fifty ladies with menstrual disturbances recruited and screened for their serum thyroid hormone levels. The means age +/- SD for whole population was 37.87 +/- 6.87 while the frequency for thyroid dysfunction was 40 (80%) with hypothyroidism being the predominant disorder 25 (50%). The common menstrual disturbances observed was menorrhagia 20(40%) and oligomenorrhea 15 (20%) respectively. CONCLUSION: Thyroid dysfunction should be taken as an important etiological factor for menstrual abnormalities.