Objective: This study aims to retrospectively investigate the contraceptive methods of different reproductive-aged women in two different regions of Yangzhou, China, to understand the changes of the contraceptive methods, and to analyze the targeted improvements of future informed choices of contraception and birth control, and reduce the occurrence of the unintended pregnancies. Materials and Methods: This study included 13,407 and 20,876 married reproductive-aged women (MCW) that were chosen from a city downtown and a county-level city, respectively, for the group-organized random sampling questionnaire survey. Results: There was a significant urban-rural difference in the choice of contraceptive methods in different MCW. The female choices of contraception were single; the accessibility of contraceptive supplies, and personalized services could improve the implementation rate of long-term contraceptive measures. The cooperation of male contraceptive responsibility was related to the education levels and enhanced male-female communication. Conclusions: It was very important for urban and rural women with different ages to choose different contraceptive measures, suggesting that these choices require the development of different educational models towards women of different ages and regions. The accessibility to various aspects of counseling and contraceptive measures should be strengthened, meanwhile male participation should also be promoted to prevent unwanted pregnancies and to reduce the health hazards related to sexual activities.