With a shift in focus from genes to cells, systems approach is not only revolutionizing cell biology, but is also providing impetus for clinical medicine to shift from a reductionistic to a holistic approach for efficient disease management. This inevitably brings into focus one of the longest unbroken healthcare systems in the world, namely ayurveda, the medical system indigenous to Indian subcontinent. A distinctive feature of ayurveda is its systems approach to health and disease. Through the theoretical framework of vata, pitta and kapha, ayurveda offers a new paradigm for understanding the human system as a networked functional entity wherein system properties are integral components. An open-minded dialogue between the cell-centric systems biology and organism-centric ayurveda can open new exciting vistas for research beneficial to both sciences, which could leave a major imprint on clinical practice.