Several frameworks for the dynamic analysis of wind-vehicle-bridge systems were presented in the past decade to study the safety or ride comfort of road vehicles as they pass through bridges under crosswinds. The wind loads on the vehicles were generally formed based on the aerodynamic parameters of the stationary vehicles on the ground, and the wind loads for the pure bridge decks without the effects of road vehicles. And very few studies were carried out to explore the dynamic effects of the aerodynamic interference between road vehicles and bridge decks, particularly for the moving road vehicles. In this study, the aerodynamic parameters for both the moving road vehicle and the deck considering the mutually-affected aerodynamic effects are formulized firstly. And the corresponding wind loads on the road vehicle-bridge system are obtained. Then a refined analytical framework of the WVB system incorporating the resultant wind loads, a driver model, and the road roughness in plane to fully consider the lateral motion of the road vehicle under crosswinds is proposed. It is shown that obvious lateral and yaw motions of the road vehicle occur. For the selected single road vehicle passing a long span bridge, slight effects are caused by the aerodynamic interference between the moving vehicle and deck on the dynamic responses of the system.