In this paper, a segmentation-based approach to fine registration of multispectral and multitemporal very high resolution (VHR) images is proposed. The proposed approach aims at estimating and correcting the residual local misalignment [also referred to as registration noise (RN)] that often affects multitemporal VHR images even after standard registration. The method extracts automatically a set of object representative points associated with regions with homogeneous spectral properties (i.e., objects in the scene). Such points result to be distributed all over the considered scene and account for the high spatial correlation of pixels in VHR images. Then, it estimates the amount and direction of residual local misalignment for each object representative point by exploiting residual local misalignment properties in a multiple displacement analysis framework. To this end, a multiscale differential analysis of the multispectral difference image is employed for modeling the statistical distribution of pixels affected by residual misalignment (i.e., RN pixels) and detect them. The RN is used to perform a segmentation-based fine registration based on both temporal and spatial correlation. Accordingly, the method is particularly suitable to be used for images with a large number of border regions like VHR images of urban scenes. Experimental results obtained on both simulated and real multitemporal VHR images confirm the effectiveness of the proposed method.