BACKGROUND Psoriasis is one of the most common dermatological conditions seen in the daily practice. Psoriasis is known to be associated with lipid profile abnormality, increased fasting blood glucose levels, increased waist circumference and increase in blood pressures which collectively constitute the so called metabolic syndrome. The objectives of this studyTo study the serum lipid profile among psoriasis patients attending our hospital. To study serum lipids in relation to the severity of psoriasis among these patients. MATERIALS AND METHODS The study was conducted at Navodaya Medical College Hospital and Research Centre, Raichur. 50 patients of newly diagnosed psoriasis who had not received any prior topical or systemic treatment were randomly selected for the study and matched with 50 age and sex matched controls. A complete lipid profile was estimated with measurement of blood pressure. Collection of Data-Blood samples were collected after obtaining proper consent from all cases and controls. Serum lipids were measured by enzymatic method. RESULTS A total of 50 consecutive cases of psoriasis were screened, examined and recruited. A detailed history was taken and thorough examination was carried out. 50 age and sex matched controls were also recruited. Blood tests were then carried out to assess levels of total cholesterol, LDL, VLDL and HDL. Majority (26%) of the patients belonged to 31 -40 years' age group. Male: female ratio was 3.2: 1.2 (4%), patients had mild psoriasis (PASI10). Psoriatic arthritis was noted in 12% (6 patients) of the cases. 22% of the patients had concomitant diabetes, while 16% of the patients had coexistent hypertension. Amongst the various lipid parameters, slight elevation was found only in triglyceride values, while other parameters like HDL, VLDL, LDL and Total Cholesterol did not show any significant association. Further there was no correlation of abnormality in lipid parameters with the severity of disease. CONCLUSION Our study did not show any association of psoriasis with abnormality in the lipid profile. The plenty of reports from West approving such an association can be explained on the basis of increased prevalence of obesity, abnormal BMI and hypertension as compared to Indian patients.