The angiotensin-converting-enzyme inhibitor induced angioedema (ACEi AE) is the most commen angioedema in the upper airway. The bradykinin B2 receptor antagonist icatibant is effective in ACEi AE. The drug is not approved officially for this indication and has to be administered in an emergency situation off-label. Corticosteroids or antihistamines do not seem to work in this condition. The effectiveness of C1-esterase-inhibitor in ACEi AE must be verified in a double-blind study.