In this work, an 8-channel high-voltage (HV) stimulation chip for the rehabilitation of stroke patients through surface stimulation is presented. The chip receives control data through its serial peripheral interface and can be controlled by an external microcontroller. It can accordingly generate biphasic stimulation currents with different amplitudes, duration time, frequencies, and polarities for each channel independently. The chip was designed and fabricated using X-FAB 0.35 mu m HV mixed-signal process. Circuits were carefully designed to ensure their operations under HVs. Our measurement results showed that a supply voltage of as high as 75V can be achieved, and the current driver can generate biphasic stimuli with current amplitudes up to 4 mA. Copyright (C) 2015 John Wiley & Sons, Ltd.