Purpose: The purpose of this article is to analyze the strengths and limitations of research designs of studies implementing coping based training interventions in adolescents. Methods: Quantitative and mixed methods studies were selected and reviewed for critical analysis of strengths, limitations, and validity concerns. Results: Methodological strengths and weaknesses were assessed. The major limitation to the studies reviewed is selection bias in both quasi-experimental studies and randomized controlled trials. Practice implications: Improved coping strategies and skills were found in participants of coping skill training intervention programs. Decreased depressive symptoms and less impact of individual disease burden was found in the treatment intervention groups.