Recently a new methodology was developed for automated fatigue crack growth (FCG) life analysis of components based on finite element stress models, weight function stress intensity factor solutions, and algorithms to define idealized fracture geometry models. This paper describes how the new methodology is being used to integrate FCG analysis into highly automated design assessments of component life and reliability. In one application, the FCG model automation is supporting automated calculation of fracture risk due to inherent material anomalies that can occur anywhere in the volume of the component. Automated schemes were developed to divide the component into a computationally optimum number of sub-volumes with similar life and risk values to determine total component reliability accurately and efficiently. In another application, the FCG model automation is supporting integration of FCG life calculations with manufacturing process simulation to perform integrated computational materials engineering. Calculation of full-field, location-specific residual stresses or microstructure is being linked directly with automated life analysis to determine the impact of manufacturing parameters on component reliability.