In competitive sports a number of physiological, biomechanical, environmental and psychological factors interact to cause increased susceptibility or vulnerability to injury. We now better understand the importance of psychological variables in the origin of injuries, a number of previous studies have identified certain factors that could predict sports injuries. The aim of this study is to analyze the influence of psychological characteristics associated with athletic performance, competitive trait anxiety and mood in injury occurrence. Participants were 115 athletes, members of specialization programs, who were administered the Psychological Inventory on Athletic Execution (IPED), Sport Competition Anxiety Test (SCAT) and Profile of Mood States (POMS). Subsequent lesions were recorded over a period of 10 months. The results indicate that self-confidence and competitive trait anxiety were significant predictors of the number of injuries. Moreover, this relationship between injuries, anxiety and self-confidence is maintained when the effect of other variables is controlled. These results are discussed and a series of considerations at the applied level are proposed.