Objective: To evaluate the association between overactive bladder syndrome (OBS) and depression among older women. Methods: One hundred sixty-nine older women answered 2 questionnaires: the Overactive Bladder (OAB-V8) and the Yesavage Geriatric Depression Scale. Results: One hundred twenty-nine participants (76.3%) had symptoms of OBS (OAB-V8 8 points). Among those with OBS, 42.6% exhibited mild or severe depression. A significant correlation was found between OBS and depression (r = 0.354; P = .001). Conclusions: A high prevalence rate of OBS was found in older women and a large portion of these women exhibited symptoms of mild and severe depression.