BACKGROUND The number of people living with HIV/AIDS is on the rise, so are the problems like renal dysfunction which needs to be addressed. The study was aimed at providing data regarding prevalence and the association of certain modifiable and non-modifiable factors with renal function. MATERIALS AND METHODS This was a cross-sectional study on 390 HIV positive subjects. Renal function was assessed by means of eGFR, calculated using Cockcroft-Gault equation and proteinuria, estimated by spot Urine Albumin Creatinine Ratio (UACR). Renal dysfunction was identified by either eGFR30 mg/gm. The data was analysed based on demographic characteristics, type and duration on ART, height, weight, body mass index, CD4 count, blood pressure and fasting lipid profile between renal dysfunction group and normal renal function group. RESULTS 21.3% (n = 83) of study population had renal dysfunction. Sixty percent of them were females. Higher mean duration of ART (40.3 months) and lower mean CD4 counts (312.6 cells/mm(3)) was associated with renal dysfunction. Mean height (162.6 cm) and mean weight (55.3 Kgs) were lower in renal dysfunction group and significant. Mean LDL cholesterol (100.3 mg/dL) and serum triglycerides (197.0 mg/dL) were higher among renal dysfunction group. Different types of ART regimen, BMI, blood pressure, HDL cholesterol and total cholesterol was found to have insignificant association in the study. CONCLUSION Every one in five HIV positive subjects might have renal insufficiency and more so common in females. Lower height, lower weight, increased duration of ART therapy were associated with decreased renal function and has to be screened. Different types of ART regimen, body mass index, systolic and diastolic blood pressure did not show any effect on renal function in this study. Decrease in CD4 count was shown to have positive correlation with decrease in estimated GFR. So subjects with greater immunosuppression should be screened frequently. High triglyceride levels and high LDL levels are associated with decreased renal function.