An accurate analysis of the flow transient is very important in safety evaluation of a nuclear power plant. In this study, analysis of a VVVVER-1000 reactor is investigated. In order to perform this analysis, a model is developed to simulate the coupled kinetics and thermal-hydraulics of the reactor with a simple and accurate numerical algorithm. For thermal-hydraulic calculations, the four-equation drift-flux model is applied. Based on a multi-channel approach, core is divided into some regions. Each region has different characteristics as represented in a single fuel pin with its associated coolant channel. To obtain the core power distribution, point kinetic equations with different feedback effects are utilized. The appropriate initial and boundary conditions are considered and two situations of decreasing the coolant flow rate in a protected and unprotected core are analyzed. In addition to analysis of normal operation condition, a full range of thermal-hydraulic parameters is obtained for transients too. Finally, the data obtained from the model are compared with the calculations conducted using RELAP5/MOD3 code and Bushehr nuclear power plant data. It is shown that the model can provide accurate predictions for both steady-state and transient conditions.