In this work we focus on the temporal and spatial characteristics of TGFbeta2 expression in various human eye tissues during prenatal development from fetal weeks 8 to 22. We used the complex approach: the analysis of TGFbeta2 gene expression by PCR and the localization of TGFbeta2 protein by immunohistochemistry. TGFbeta2 was detected in all eye tissues. Our results suggest that differential expression pattern of TGFbeta2 in the lens and retina is correlated with the cell type and differentiation state. The data obtained give evidence to the TGFbeta2 contribution to forming of eye tissues of various embryonic origins.