The human factor is a key variable in the efficiency of the product-process development system. The ability to be able to predict the influence of this factor in the process is a significant challenge in manufacturing engineering, as well as the consequences that the process designed has on this factor. All ergonomic considerations have traditionally been evaluated without using 3D product design. Nowadays, 3D process design technologies and simulation tools allow us the opportunity from the earliest stages of the design process. They can also be used to improve current processes in order to increase human comfort, productivity and safety. This paper describes a methodology using 3D design and simulation tools to improve industrial and service processes. This methodology has as an objective the detection, evaluation and control of work-related musculoskeletal disorders (WMSDs).