The seismic response of the Wusong bridge was analyzed though the response spectrum method and the time-history method by adopting the MIDAS/CIVIL. The analysis results show that the longitudinal displacement of the main girder is much larger under longitudinal seismic input, so some inhibiting device or dampers should be used to avoid impacting. There is not coupling between longitudinal and lateral seismic excitations, while the seismic response of moment and shear force at the bottom of the main tower is much larger. On the contrary the seismic response of main beam and the main cable should be calculated under the longitudinal and vertical seismic excitations because of the coupling between the both of them. Furthermore, the artificial seismic wave fitting standard response spectrum was generated to conduct the time-history analysis and the results are much larger than the results from the response spectrum method.