Based on the characteristics and teaching problems of electronic technology courses, this paper proposed to use the multisim simulation software in the whole process of analog electronic technology teaching, integrating theory and practice of teaching, which strengthen the theory teaching and make up for the lack of hardware in experimental teaching. The teaching practice of basic amplifier and integrated operational amplifier that are core components in analog electronics, for example, the analysis based on the integration of theory and practice in teaching methods of multisim stimulate students' interest in learning, improve learning initiative, and enhance understanding of the content students learned as well as their practical abilities, developing sense of innovation and achieving ideal teaching effect.