OBJECTIVES. Stress and odontophobia represent a major problem for operators committed to the proper and smooth conduct of therapies. Where a simple verbal approach is not enough, the most common solution is to make use of medications. The present work evaluates how a virtual reality system can allow for the stabilization of the patients' cardiovascular parameters and the consequent management of stress. MATERIALS AND METHODS. 29 non dentophobic patients, mean age 33.8 +/- 12.8 years, were subjected to tartar ablation with and without the use of video-glasses Unidexx All-in-One (UNIDEXX Srl, Pomezia, RM, Italy). At the completion of treatment, the patients' pressure and heart rate were measured. RESULTS AND CONCLUSIONS. A statistically significant result was obtained with the use of a combined audio/video system, while audio only (music) did not produce equally significant results. This preliminary study make it possible to observe how the use of a virtual reality system serves to effectively stabilize or even reduce cardiovascular factors related to a state of stress. Further studies will be needed to confirm the obtained results.