Despite Latino youth being at increased risk of developing mental health problems, they are less likely to receive adequate treatment (Gonzales et al. in Handbook of U.S. Latino psychology: developmental and community-based perspectives. Sage, Thousand Oaks, pp 115-134, 2009; Romero et al. in Ethn Health 12(5):443-463, 2007; Smokowski et al. in J Community Psychol 37(8):1024-1045, 2009; Flores in Pediatrics 125(4):e979-e1020, 2010). Better understanding of the factors that influence psychosocial outcomes for Latino youth is crucial to addressing existing mental health disparities. In order to build on existing knowledge of factors that promote positive mental health outcomes for Latino youth, the current study examined sociocultural influences on Latino early adolescents' global self-worth. In particular, researchers investigated the effects of acculturation and acculturation risk factors on early adolescents' perceptions of global self-worth. Seventy-nine Latino early adolescents completed a series of questionnaires assessing behavioral and cognitive aspects of acculturation (i.e., ethnic culture of origin, US mainstream culture, and biculturalism), acculturation risk factors (i.e., acculturation stress, acculturation conflict, and perceived ethnic discrimination), and global self-worth. Results suggested that specific cultural orientations were associated with increased global self-worth, and increased levels of acculturation risk factors were associated with decreased global self-worth. Acculturation conflict was the most salient predictor of global self-worth, and regression analyses indicated that the effects of acculturation stress, acculturation conflict, and perceived ethnic discrimination on global self-worth depended on youth's cultural orientation on the behavioral and cognitive measures of acculturation. Results indicate the importance of assessing both cognitive and behavioral aspects of acculturation, as well as the way in which acculturation moderates the relation between acculturation risk factors and early adolescents' perceptions of global self-worth.