ObjectiveTo identify risk factors for canine lymphoma in dogs from New South Wales, Australia, and to compare factors affecting remission duration. MethodsClient-owned dogs diagnosed with lymphoma presented to the University Veterinary Teaching Hospital (UVTH), University of Sydney, between 2001 and 2009 (n=134) were compared with a control population of dogs seen in that period of time with a diagnosis other than lymphoma to evaluate association of explanatory variables (breed, age and sex) with the outcome (case or control status). ResultsThe Australian Cattle Dog (odds ratio (OR)=4.71; 95% confidence interval (Cl) 2.31-9.62; P<0.001), Doberman (OR=7.64; 95% Cl 2.87-20.34; P=0.001) and Rottweiler (OR=4.52; 95% Cl 2.09-9.73; P=0.001) had increased odds of lymphoma among dogs attending the UVTH compared with crossbreds. The results suggested that the Border Collie (OR=3.38; 95% Cl 1.52-7.53; P=0.008) and Boxer (OR=3.85; 95% Cl 1.65-8.95; P=0.006) also have increased odds of lymphoma among the pure-breed dogs attending the UVTH when compared with crossbred dogs. ConclusionsThe results of this study confirmed a breed predilection for lymphoma in dogs, with the Australian Cattle Dog and Doberman having increased odds of lymphoma.