This paper is concerned with constructing nodal radial solutions for generalized quasilinear Schrodinger equations in RN with critical growth which arise from plasma physics, fluid mechanics, as well as the self-channeling of a high-power ultashort laser in matter. We find the critical exponents for a generalized quasilinear Schrodinger equations and obtain the existence of sign-changing solution with k nodes for any given integer k >= 0.