In this brief, a 1-V potentiostat circuit for a glucose sensor has been proposed. Test results of this 1-V potentiostat demonstrate high linearity with respect to glucose concentration, which is comparable with conventional potentiostat designs. This high linearity is achieved with the help of a transconductance enhanced bulk-driven operational amplifier. The overall current consumption of the circuit is around 22 mu A. The potentiostat is tested as a glucose biosensor for glucose concentration ranging from 0 to 30 mM. The design is realized in a 0.35-mu m bulk-CMOS process, and the area for the core layout is 0.13 mm(2). The proposed low-power potentiostat can be incorporated in an implantable glucose sensor system due to its low-power operation and small footprint.