KeeLoq algorithm with high security was usually used in wireless codec. Its security lack is indicated in this article according to the detailed rationale and the introduction of previous attack researches. Taking examples from Triple Data Encryption Standard algorithm, the triple KeeLoq codec algorithm was first proposed. Experimental results showed that the algorithm would not reduce powerful rolling effect and in consideration of limited computing power of embedded microcontroller three 64-bit keys were suitable to increase the crack difficulties and further improved its security. The method was applied to intelligent door access system for experimental verification. 16F690 extended Bluetooth or WiFi interface was employed to design the lock system on door. Key application was constructed on Android platform. The wireless communication between the lock on door and Android key application employed triple KeeLoq algorithm to ensure the higher security. Due to flexibility and multiformity (an Android key application with various keys) of software-based keys, the solution owned overwhelmed advantages of low cost, high security, humanity, and green environmental protection.