In this paper, the global operating point dependent losses of induction machines are studied utilizing a local transient loss formulation. After calculating the local loss distribution, the losses are integrated in space and averaged in time to get the average global losses. The main loss components Ohmic losses, iron losses and friction losses are considered. The Ohmic losses in stator and rotor are dependent on current values and the time-and local-waveform due to current displacement. The iron losses are highly dependent on flux density, base frequency, and harmonic distortion of the flux density. The level of flux, the machine is operated at, depends on the operation mode of the inverter. Hence for precise loss modeling of inverter driven induction machines at the machine design stage, time and spatial distribution of flux density and the influence of choosing the best operating point is included.