Context: Soluble CD40 ligand (sCD40l) can predict cardiovascular events (CVE) and mortality in haemodialysis (HD) patients (short-, medium-term follow-up studies).Objective: To evaluate the relationship between sCD40l and survival, CVE and mortality in HD patients on long-term follow-up.Methods: We registered 46HD patients' baseline characteristics, mortality and CVE for 108 months.Results: SCD40l correlated positively with C-reactive protein, was higher in survivors, but had no impact on survival and was not predictive for CVE or CV mortality.Conclusion: The levels of sCD40l have no influence on survival or CVE and mortality in HD patients in a long-term follow-up.