The most viable therapy for curing type 1 diabetes mellitus is pancreatic islet transplantation. However, they are unavoidable in terms of immunogenicity, which is differently affected by transplantation site. Therefore, it is necessary to determine alternate sites to permit successful islet transplantation outcomes. This paper reviews evidence that the anterior chamber of the eye (ACE) could be a good site for islet transplantation when compared to other alternate sites. In addition, this site may be a promising technical platform for noninvasive in vivo imaging of transplanted pancreatic islets. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.