Purpose of the Review In this review, we will discuss the basic fundamentals of how to perform molecular imaging to better understand the underlyingmechanisms contributing to cardiovascular disease. Report Findings Molecular imaging combines molecular biology with in vivo imaging. Molecular probes are used to target discrete biological processes such as cell death, inflammation, and angiogenesis. These probes emit signals that are detected by traditional imaging systems. Because the same disease processes can manifest in individuals in different ways, molecular imaging may emerge as an important strategy for delivering precision medicine. Summary Molecular imaging is a powerful tool that may help physicians provide more personalized care in the near future.