Introduction: Organizations can successfully achieve their mission and objectives when they benefit from a competent and effective management; since it is the most important factor in the organization's survival and success. The aim of this study is to determine the influential determinants of human resources development among the health services senior managers and commanders. Method: This descriptive and analytical research was undertaken through a cross-sectional study in late 2009. The sample included 157 people from among the health services' managers and commanders of the studied organization. Data was collected through a questionnaire and was analyzed using the SPSS software. Findings: The results showed that the influential determinants for development of the senior health service managers and commanders consisted of ideological, innovation, behavioral, perception skill, technical skills, human skills, decision making skill, physical capabilities, spiritual ability, mental ability, motivation, attitude, team work, communication, intelligence, learning, technical knowledge, and general/basic knowledge. The importance of the mentioned determinants for the top management of such organizations is significantly more than 75 percent. Conclusion: Overall, based on the results of this research the most important influential determinants lie in ideological, innovation and behavioral areas. Accordingly, it is recommended that these important determinants should be emphasized in human resources development for the managers. Besides, the talent-seeking activities should be performed based on these determinants.