A constrained output feedback model predictive control approach for nonlinear systems is presented in this paper. The state variables are observed using an unscented Kalman filter, which offers some advantages over an extended Kalman filter. A nonlinear dynamic model of the system, considered in this investigation, is developed considering all possible effective elements. The model is then adaptively linearized along the prediction horizon using a state-dependent state space representation. In order to improve the performance of the control system as many linearized models as the number of prediction horizons are obtained at each sample time. The optimum results of the previous sample time are utilized for linearization at the current sample time. Subsequently, a linear quadratic objective function with constraints is formulated using the developed governing equations of the plant. The performance and effectiveness of the proposed control approach is validated both in simulation and through real-time experimentation using a constrained highly nonlinear aerodynamic test rig, a twin rotor MIMO system (TRMS). (c) 2011 Elsevier Ltd. All rights reserved.