Based on recent findings, the main span of the Vincent Thomas suspension bridge crosses directly over the Palos Verdes fault, which has the capacity to produce a devastating earthquake. In spring 2000, the bridge underwent a major retrofit using visco-elastic dampers. This study focuses on seismic vulnerability of the retrofitted bridge. Three-dimensional memberbased detailed and panel-based simplified finite element models of the bridge are developed. In order to show the appropriateness of these models, eigenproperties of the bridge are evaluated and compared with the system identification results obtained using ambient vibration data. In addition, a model validation is performed by simulating the dynamic response during the 1994 Northridge earthquake and comparing with the measured response. Finally, considering a set of strong ground motions in the Los Angeles area, nonlinear time history analyses are performed and the ductility demands of critical sections are presented in terms of fragility curves. The study shows that a ground motion with peak ground acceleration of 0.9 g or greater will result in plastic hinge formation at one or more locations with a probability of exceedance of 50%. Also, it is found that the effect of dampers is minimal for low to moderate earthquakes and high for strong earthquakes.