Introduction. Patient's behavioral and psychological factors are key determinants of medical treatment adherence while representing a research and management challenge. Purpose. Highlighting the implication of behavioral and psychological factors associated with patients' compliance to medical treatment and therapeutic success in relation to acute coronary syndrome. Methods. We monitored seventeen patients hospitalized with acute coronary syndrome using qualitative observational analysis; they were divided into two groups: Group 1 (10 patients)-patients with ST-segment elevation myocardial infarction (STEMI), and group 2 (7 patients) with angina pectoris (AP) and non-ST-segment elevation myocardial infarction (NSTEMI). Patients were monitored at one month both in terms of clinical and biological indicators and echocardiography - according to current guidelines. For psychological assessment we used self-rated questionnaire for health related behavioral, Health Perception Scale, Depression Scale (HADS-D) and Health Locus of Control Scale. Results. We have identified a higher degree of receptivity and responsibility in adopting health promoting behaviors in patients having less severe cardiac pathology (i.e. angina pectoris and a mild to moderate systolic dysfunction). All the other patients came regularly at one month. We noticed high scores regarding the information and knowledge profile for all three levels: clarity of information on their current clinical state, specific medical treatment and recommended healthy behaviors for both groups. Both groups of patients exhibited high degree of receptivity and responsibility in adopting health promoting behavior as regards stress management and check-up visits attendance. In-depth analysis revealed that patients' confidence in therapy, stress management and check-up visits attendance significantly correlated with overall level of knowledge. Additionally, self-perception of projected health, present overall satisfaction and future overall satisfaction significantly correlated with information and knowledge profile. Conclusions. In medium to long term management of ischemic cardiac disease, the psychological and behavioral factors are relevant players, which should be part of patients' assessment algorithm in order to improve the adoption of healthy behaviors and treatment adherence.