The "materials genome" was given a rather vague definition in US President Obama's announcement in 2011. We argue that the materials genome, analogously with biological genomes, should be defined as a set of information (databases) allowing prediction of a material's structure, as well as its response to processing and usage conditions. The materials genome is thus encoded in the language of CALPHAD thermodynamics and kinetics, as such databases are major parts of integrated computational materials engineering. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.