This paper presents an interval effective independence method for optimal sensor placement, which contains uncertain structural information. To overcome the lack of insufficient statistic description of uncertain parameters, this paper treats uncertainties as non-probability intervals. Based on the iterative process of classical effective independence method, the proposed study considers the eliminating steps with uncertain cases. Therefore, this method with Fisher information matrix is extended to interval numbers, which could conform to actual engineering. As long as we know the bounds of uncertainties, the interval Fisher information matrix could be obtained conveniently by interval analysis technology. Moreover, due to the definition and calculation of the interval relationship, the possibilities of eliminating candidate sensors in each iterative process and the final layout of sensor placement are both presented in this paper. Finally, two numerical examples, including a five-storey shear structure and a truss structure are proposed respectively in this paper. Compared with Monte Carlo simulation, both of them can indicate the veracity of the interval effective independence method.