In satellite group animals treated with COMPOUND_XXX at 120 or 180 mg / kg / day for 28 days , COMPOUND_XXX and COMPOUND_XXX heart tissue concentrations were markedly increased compared to plasma concentrations ( heart / plasma concentration ratios : COMPOUND_XXX : 29 - 38 , COMPOUND_XXX : 35 - 49 ) thus indicating accumulation of COMPOUND_XXX and its metabolite COMPOUND_XXX in the heart .
In satellite group animals treated with COMPOUND_XXX at 120 or 180 mg / kg / day for 28 days , COMPOUND_XXX and COMPOUND_XXX heart tissue concentrations were markedly increased compared to plasma concentrations ( heart / plasma concentration ratios : COMPOUND_XXX : 29 - 38 , COMPOUND_XXX : 35 - 49 ) thus indicating accumulation of COMPOUND_XXX and its metabolite COMPOUND_XXX in the heart .
O B-GROUP I-GROUP O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O