Microscopically , there were liver findings of an inflammatory nature in three of four dogs at 60 mg / kg / day , characterized by periportal / sinusoidal inflammatory cell infiltration as well as Kupffer cell hypertrophy / hyperplasia and centrilobular bile stasis in both high - dose females and one high - dose male .
Microscopically , there were liver findings of an inflammatory nature in three of four dogs at 60 mg / kg / day , characterized by periportal / sinusoidal inflammatory cell infiltration as well as Kupffer cell hypertrophy / hyperplasia and centrilobular bile stasis in both high - dose females and one high - dose male .
O O O O B-SPECIMEN B-FINDING O O B-FINDING O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O O B-FINDING I-FINDING I-FINDING O B-FINDING O B-FINDING I-FINDING I-FINDING O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION B-SEX O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION B-SEX O