Under the conditions of this study , the low dose level of 0.15 mg / kg / occasion is considered to be the No Observed Effect Level ( NOEL ) , and the dose of 1.0 mg / kg / occasion is considered the maximal tolerated dose for COMPOUND_XXX when administered for 13 weeks by oral gavage as 3 doses per week using a Monday , Wednesday and Friday dosing schedule .
Under the conditions of this study , the low dose level of 0.15 mg / kg / occasion is considered to be the No Observed Effect Level ( NOEL ) , and the dose of 1.0 mg / kg / occasion is considered the maximal tolerated dose for COMPOUND_XXX when administered for 13 weeks by oral gavage as 3 doses per week using a Monday , Wednesday and Friday dosing schedule .
O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O