An increase in dose resulted in a generally proportional increase in exposure between the two lower doses ; exposure at the highest dose appeared to be under - proportional .
An increase in dose resulted in a generally proportional increase in exposure between the two lower doses ; exposure at the highest dose appeared to be under - proportional .
O O O O O O O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O