The incidence and severity of these signs were dose - dependent , with any signs observed at the Low dose level being of minimal or mild severity .
The incidence and severity of these signs were dose - dependent , with any signs observed at the Low dose level being of minimal or mild severity .
O O O O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O O