Systemic exposure and maximum serum concentrations increased almost to the same extent as the dose from the medium to the high dose .
Systemic exposure and maximum serum concentrations increased almost to the same extent as the dose from the medium to the high dose .
O O O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O