The changes were more pronounced after treatment with COMPOUND_XXX when compared to treatment with , i.e. at the end of the 28 - day treatment period , foci of acute myocardial necrosis were noted in several rats treated with COMPOUND_XXX at > 120 mg / kg / day and the incidence and severity of inflammatory focus , characterized by granulation tissue with or without inflammatory cell infiltration , were increased after COMPOUND_XXX treatment at > 120 mg / kg / day when compared to control animals or rats treated with .
The changes were more pronounced after treatment with COMPOUND_XXX when compared to treatment with , i.e. at the end of the 28 - day treatment period , foci of acute myocardial necrosis were noted in several rats treated with COMPOUND_XXX at > 120 mg / kg / day and the incidence and severity of inflammatory focus , characterized by granulation tissue with or without inflammatory cell infiltration , were increased after COMPOUND_XXX treatment at > 120 mg / kg / day when compared to control animals or rats treated with .
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