Macroscopic liver changes were observed in one animal from the high dose group only but histology revealed changes from the mid dose on including vacuolation of hepatocytes and Kupffer cells , necroses , and hepatic hematopoiesis .
Macroscopic liver changes were observed in one animal from the high dose group only but histology revealed changes from the mid dose on including vacuolation of hepatocytes and Kupffer cells , necroses , and hepatic hematopoiesis .
O B-SPECIMEN B-FINDING O O O O O O O B-GROUP I-GROUP I-GROUP O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O B-FINDING I-FINDING I-FINDING O O O O B-FINDING O O B-FINDING I-FINDING O