Mean concentrations of COMPOUND_XXX in mouse plasma Target dose ( mg / kg / day ) Mean COMPOUND_XXX concentration ( ng / ml ) ( SD ) 60 5.66 ( 3.59 ) 200 40.4 ( 19.9 ) 600 86.9 ( 34.4 ) At microscopic examination , dose - dependent mucosal hyperplasia was observed m the jejunum ( minimal to slight ) and ileum ( minimal ) at 200 and 600 mg / kg / day .
Mean concentrations of COMPOUND_XXX in mouse plasma Target dose ( mg / kg / day ) Mean COMPOUND_XXX concentration ( ng / ml ) ( SD ) 60 5.66 ( 3.59 ) 200 40.4 ( 19.9 ) 600 86.9 ( 34.4 ) At microscopic examination , dose - dependent mucosal hyperplasia was observed m the jejunum ( minimal to slight ) and ileum ( minimal ) at 200 and 600 mg / kg / day .
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