However , a sufficiently high systemic exposure to identify potential target organs could not be achieved due to limited oral bioavailability resulting in systemic exposures which did not increase relevantly on increasing the dose from 100 to 300 mg / kg .
However , a sufficiently high systemic exposure to identify potential target organs could not be achieved due to limited oral bioavailability resulting in systemic exposures which did not increase relevantly on increasing the dose from 100 to 300 mg / kg .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O