Forty ( 40 ) young adult male Charles River CD rats ( Sprague - Dawley ) were randomly divided into four groups of 10 animals each and administered 212 - 713 ( COMPOUND_XXX ; hydrogen tartrate salt ) in suspension ( 1 % CMC plus 0.2 % Tween 80 ) by gavage ( rigid oral feeding needle ) for 15 consecutive days as follows : Group I , Control ; Group II , 0.04 mg ; kgjday ; Group III , 0.4 mg / kg / day ; Group IV , 4 mgjkgjday ( base equivalent dose levels : 0 , 0.025 , 0.25 and 2.5 mg / kgjday , respectively ) .
Forty ( 40 ) young adult male Charles River CD rats ( Sprague - Dawley ) were randomly divided into four groups of 10 animals each and administered 212 - 713 ( COMPOUND_XXX ; hydrogen tartrate salt ) in suspension ( 1 % CMC plus 0.2 % Tween 80 ) by gavage ( rigid oral feeding needle ) for 15 consecutive days as follows : Group I , Control ; Group II , 0.04 mg ; kgjday ; Group III , 0.4 mg / kg / day ; Group IV , 4 mgjkgjday ( base equivalent dose levels : 0 , 0.025 , 0.25 and 2.5 mg / kgjday , respectively ) .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP O B-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE O B-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-GROUP I-GROUP O B-DOSE I-DOSE O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O