The positive control article propylthiouracil ( PTU ) was administered daily at a dose of 10 mg / kg via oral gavage at a dose volume of 5 mL / kg as a suspension in 0.25 % methylcellulose , to an additional group of 90 male Han Wistar rats , for 5 ( n = 30 ) , 12 ( n = 30 ) or 26 ( n = 30 ) days .
The positive control article propylthiouracil ( PTU ) was administered daily at a dose of 10 mg / kg via oral gavage at a dose volume of 5 mL / kg as a suspension in 0.25 % methylcellulose , to an additional group of 90 male Han Wistar rats , for 5 ( n = 30 ) , 12 ( n = 30 ) or 26 ( n = 30 ) days .
O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O