CONCLUSION The oral administration of COMPOUND_XXX for 1 month to rats at doses of 10 , 30 and 100 mg / kg / day resulted in compound - related mortality in 1/16 males at 100 mg / kg / day ; no clinical signs and no ocular abnormalities at whatever the dose ; body weight gain decreases throughout the study primarily in males treated at 100 mg / kg / day , with decreases in food intake .
CONCLUSION The oral administration of COMPOUND_XXX for 1 month to rats at doses of 10 , 30 and 100 mg / kg / day resulted in compound - related mortality in 1/16 males at 100 mg / kg / day ; no clinical signs and no ocular abnormalities at whatever the dose ; body weight gain decreases throughout the study primarily in males treated at 100 mg / kg / day , with decreases in food intake .
O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O B-FINDING O O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD B-MANIFESTATION_FINDING O O O O O B-SEX O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O