In contrast , oral administration of COMPOUND_XXX produced minimal and often transient changes in thyroid hormone levels ( increases in TSH , decreases in T3 and T4 ) , which were not accompanied by organ weight or microscopic changes in the thyroid , pituitary or liver .
In contrast , oral administration of COMPOUND_XXX produced minimal and often transient changes in thyroid hormone levels ( increases in TSH , decreases in T3 and T4 ) , which were not accompanied by organ weight or microscopic changes in the thyroid , pituitary or liver .
O O O O O O O O O O O O B-MANIFESTATION_FINDING O B-SPECIMEN B-STUDY_TESTCD I-STUDY_TESTCD O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O B-STUDY_TESTCD O O O O O O O O O O O O O O O O O O O O