Repeat dosing of male and female Wistar rats with COMPOUND_XXX 3 at 80 , 160 and 320 mg / kg induced dose - related changes in appearance and behaviour from the low dose .
Repeat dosing of male and female Wistar rats with COMPOUND_XXX 3 at 80 , 160 and 320 mg / kg induced dose - related changes in appearance and behaviour from the low dose .
O O O B-SEX I-SEX I-SEX O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O