Based on the sciatic nerve degeneration resulting from severe hypoglycemia at dose levels of 150 and 450 mg / kg / day , the no - observable adverse effect level ( NOAEL ) for the current study is 50 mg / kg / day which corresponds to COMPOUND_XXX AUC 0 - 24 hr and C max values of 8,730 ng * hr / ml and 1,440 ng / ml , in males and 18,600 ng * hr / ml and 4,390 ng / ml in females , respectively , on day 15 .
Based on the sciatic nerve degeneration resulting from severe hypoglycemia at dose levels of 150 and 450 mg / kg / day , the no - observable adverse effect level ( NOAEL ) for the current study is 50 mg / kg / day which corresponds to COMPOUND_XXX AUC 0 - 24 hr and C max values of 8,730 ng * hr / ml and 1,440 ng / ml , in males and 18,600 ng * hr / ml and 4,390 ng / ml in females , respectively , on day 15 .
O O O B-SPECIMEN I-SPECIMEN B-FINDING O O O B-FINDING O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O