An increase in dose resulted in a generally proportional increase in exposure at lower doses in male rats , but generally under - proportional increases with dose in female rats and in male rats at the highest dose level .
An increase in dose resulted in a generally proportional increase in exposure at lower doses in male rats , but generally under - proportional increases with dose in female rats and in male rats at the highest dose level .
O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE O