The study was designed to establish a no observable adverse effect level ( NOAEL ) , to establish a maximal tolerated dose ( MTD ) , to estimate the toxicokinetic profile , and to estimate the potential for reversal of any toxic effects within a 4 - week post-dosing phase .
The study was designed to establish a no observable adverse effect level ( NOAEL ) , to establish a maximal tolerated dose ( MTD ) , to estimate the toxicokinetic profile , and to estimate the potential for reversal of any toxic effects within a 4 - week post-dosing phase .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O