User: I want to come up with a SMILES.
Assistant: This sounds  very curious. Should I consider any constraints for the generation?
User: Yes, please. The molecule should not be toxic in the SR-ARE assay.
Assistant: Ok, this SMILES is not toxic in the SR-ARE assay: O=C1OC(=O)c2cc(-c3ccc4c(c3)C(=O)OC4=O)ccc21
User: I want to come up with a SMILES.
Assistant: This sounds  very curious. Should I consider any constraints for the generation?
User: Yes, please. The molecule should not be toxic in the SR-ARE assay.
Assistant: Ok, this SMILES is not toxic in the SR-ARE assay: O=C1OC(=O)c2cc(-c3ccc4c(c3)C(=O)OC4=O)ccc21