





from collections import defaultdict


def  SCREAMING_SNAKE_CASE   ( _UpperCAmelCase		,			_UpperCAmelCase				)    ->  bool:
    lowerCamelCase__					:   Dict      				=	first_str.lower().strip()
    lowerCamelCase__					:   Optional[int]      				=	second_str.lower().strip()

    # Remove whitespace
    lowerCamelCase__					:   Tuple      				=	first_str.replace(' '		,			''				)
    lowerCamelCase__					:   Tuple      				=	second_str.replace(' '		,			''				)

    # Strings of different lengths are not anagrams
    if len(_UpperCAmelCase				) != len(_UpperCAmelCase				):
        return False

    # Default values for count should be 0
    lowerCamelCase__					:   defaultdict[str, int]      				=	defaultdict(_UpperCAmelCase				)

    # For each character in input strings,
    # increment count in the corresponding
    for i in range(len(_UpperCAmelCase				)				):
        count[first_str[i]] += 1
        count[second_str[i]] -= 1

    return all(_count == 0 for _count in count.values()				)


if __name__ == "__main__":
    from doctest import testmod

    testmod()
    _UpperCAmelCase       : str			     =       input("""Enter the first string """).strip()
    _UpperCAmelCase       : Any			     =       input("""Enter the second string """).strip()

    _UpperCAmelCase       : Tuple			     =       check_anagrams(input_a, input_b)
    print(F"""{input_a} and {input_b} are {"" if status else "not "}anagrams.""")












import dataclasses
import re
import string
from typing import Any, Dict, Iterator, List, Mapping, Optional, Sequence, Tuple

import numpy as np

from . import residue_constants


_UpperCAmelCase       : int			     =       Mapping[str, np.ndarray]
_UpperCAmelCase       : List[Any]			     =       Mapping[str, Any]  # Is a nested dict.
_UpperCAmelCase       : Dict			     =       0.01

@dataclasses.dataclass(frozen=__UpperCamelCase    )
class      lowerCAmelCase							:
 UpperCAmelCase__									=	42  # [num_res, num_atom_type, 3]

 # Amino-acid type for each residue represented as an integer between 0 and
 # 20, where 20 is 'X'.
 UpperCAmelCase__									=	42  # [num_res]

 # Binary float mask to indicate presence of a particular atom. 1.0 if an atom
 # is present and 0.0 if not. This should be used for loss masking.
 UpperCAmelCase__									=	42  # [num_res, num_atom_type]

 # Residue index as used in PDB. It is not necessarily continuous or 0-indexed.
 UpperCAmelCase__									=	42  # [num_res]

 # B-factors, or temperature factors, of each residue (in sq. angstroms units),
 # representing the displacement of the residue from its ground truth mean
 # value.
 UpperCAmelCase__									=	42  # [num_res, num_atom_type]

 # Chain indices for multi-chain predictions
 UpperCAmelCase__									=	None

 # Optional remark about the protein. Included as a comment in output PDB
 # files
 UpperCAmelCase__									=	None

 # Templates used to generate this protein (prediction-only)
 UpperCAmelCase__									=	None

 # Chain corresponding to each parent
 UpperCAmelCase__									=	None


def  SCREAMING_SNAKE_CASE   ( _UpperCAmelCase				)    ->  Protein:
    lowerCamelCase__					:   Optional[int]      				=	r'(\[[A-Z]+\]\n)'
    lowerCamelCase__					:   List[str]      				=	[tag.strip() for tag in re.split(_UpperCAmelCase		,			_UpperCAmelCase				) if len(_UpperCAmelCase				) > 0]
    lowerCamelCase__					:   Iterator[Tuple[str, List[str]]]      				=	zip(tags[0::2]		,			[l.split('\n'				) for l in tags[1::2]]				)

    lowerCamelCase__					:   List[str]      				=	["N", "CA", "C"]
    lowerCamelCase__					:   Dict      				=	None
    lowerCamelCase__					:   str      				=	None
    lowerCamelCase__					:   int      				=	None
    for g in groups:
        if "[PRIMARY]" == g[0]:
            lowerCamelCase__					:   int      				=	g[1][0].strip()
            for i in range(len(_UpperCAmelCase				)				):
                if seq[i] not in residue_constants.restypes:
                    lowerCamelCase__					:   Union[str, Any]      				=	'X'  # FIXME: strings are immutable
            lowerCamelCase__					:   Union[str, Any]      				=	np.array(
                [residue_constants.restype_order.get(_UpperCAmelCase		,			residue_constants.restype_num				) for res_symbol in seq]				)
        elif "[TERTIARY]" == g[0]:
            lowerCamelCase__					:   List[List[float]]      				=	[]
            for axis in range(3				):
                tertiary.append(list(map(_UpperCAmelCase		,			g[1][axis].split()				)				)				)
            lowerCamelCase__					:   int      				=	np.array(_UpperCAmelCase				)
            lowerCamelCase__					:   Tuple      				=	np.zeros((len(tertiary[0]				) // 3, residue_constants.atom_type_num, 3)				).astype(np.floataa				)
            for i, atom in enumerate(_UpperCAmelCase				):
                lowerCamelCase__					:   int      				=	np.transpose(tertiary_np[:, i::3]				)
            atom_positions *= PICO_TO_ANGSTROM
        elif "[MASK]" == g[0]:
            lowerCamelCase__					:   int      				=	np.array(list(map({'-': 0, '+': 1}.get		,			g[1][0].strip()				)				)				)
            lowerCamelCase__					:   List[Any]      				=	np.zeros(
                (
                    len(_UpperCAmelCase				),
                    residue_constants.atom_type_num,
                )				).astype(np.floataa				)
            for i, atom in enumerate(_UpperCAmelCase				):
                lowerCamelCase__					:   Union[str, Any]      				=	1
            atom_mask *= mask[..., None]

    assert aatype is not None

    return Protein(
        atom_positions=_UpperCAmelCase		,			atom_mask=_UpperCAmelCase		,			aatype=_UpperCAmelCase		,			residue_index=np.arange(len(_UpperCAmelCase				)				)		,			b_factors=_UpperCAmelCase		,			)


def  SCREAMING_SNAKE_CASE   ( _UpperCAmelCase		,			_UpperCAmelCase = 0				)    ->  List[str]:
    lowerCamelCase__					:   List[str]      				=	[]

    lowerCamelCase__					:   Dict      				=	prot.remark
    if remark is not None:
        pdb_headers.append(F"""REMARK {remark}"""				)

    lowerCamelCase__					:   str      				=	prot.parents
    lowerCamelCase__					:   Union[str, Any]      				=	prot.parents_chain_index
    if parents is not None and parents_chain_index is not None:
        lowerCamelCase__					:   Any      				=	[p for i, p in zip(_UpperCAmelCase		,			_UpperCAmelCase				) if i == chain_id]

    if parents is None or len(_UpperCAmelCase				) == 0:
        lowerCamelCase__					:   List[Any]      				=	['N/A']

    pdb_headers.append(F"""PARENT {" ".join(_UpperCAmelCase				)}"""				)

    return pdb_headers


def  SCREAMING_SNAKE_CASE   ( _UpperCAmelCase		,			_UpperCAmelCase				)    ->  str:
    lowerCamelCase__					:   List[str]      				=	[]
    lowerCamelCase__					:   str      				=	pdb_str.split('\n'				)

    lowerCamelCase__					:   int      				=	prot.remark
    if remark is not None:
        out_pdb_lines.append(F"""REMARK {remark}"""				)

    lowerCamelCase__					:   List[List[str]]
    if prot.parents is not None and len(prot.parents				) > 0:
        lowerCamelCase__					:   List[Any]      				=	[]
        if prot.parents_chain_index is not None:
            lowerCamelCase__					:   Dict[str, List[str]]      				=	{}
            for p, i in zip(prot.parents		,			prot.parents_chain_index				):
                parent_dict.setdefault(str(_UpperCAmelCase				)		,			[]				)
                parent_dict[str(_UpperCAmelCase				)].append(_UpperCAmelCase				)

            lowerCamelCase__					:   str      				=	max([int(_UpperCAmelCase				) for chain_idx in parent_dict]				)
            for i in range(max_idx + 1				):
                lowerCamelCase__					:   Optional[Any]      				=	parent_dict.get(str(_UpperCAmelCase				)		,			['N/A']				)
                parents_per_chain.append(_UpperCAmelCase				)
        else:
            parents_per_chain.append(list(prot.parents				)				)
    else:
        lowerCamelCase__					:   Union[str, Any]      				=	[['N/A']]

    def make_parent_line(_UpperCAmelCase				) -> str:
        return F"""PARENT {" ".join(_UpperCAmelCase				)}"""

    out_pdb_lines.append(make_parent_line(parents_per_chain[0]				)				)

    lowerCamelCase__					:   List[Any]      				=	0
    for i, l in enumerate(_UpperCAmelCase				):
        if "PARENT" not in l and "REMARK" not in l:
            out_pdb_lines.append(_UpperCAmelCase				)
        if "TER" in l and "END" not in lines[i + 1]:
            chain_counter += 1
            if not chain_counter >= len(_UpperCAmelCase				):
                lowerCamelCase__					:   Union[str, Any]      				=	parents_per_chain[chain_counter]
            else:
                lowerCamelCase__					:   Optional[Any]      				=	['N/A']

            out_pdb_lines.append(make_parent_line(_UpperCAmelCase				)				)

    return "\n".join(_UpperCAmelCase				)


def  SCREAMING_SNAKE_CASE   ( _UpperCAmelCase				)    ->  str:
    lowerCamelCase__					:   Tuple      				=	residue_constants.restypes + ['X']

    def res_atoa(_UpperCAmelCase				) -> str:
        return residue_constants.restype_atoa.get(restypes[r]		,			'UNK'				)

    lowerCamelCase__					:   int      				=	residue_constants.atom_types

    lowerCamelCase__					:   List[str]      				=	[]

    lowerCamelCase__					:   Union[str, Any]      				=	prot.atom_mask
    lowerCamelCase__					:   Union[str, Any]      				=	prot.aatype
    lowerCamelCase__					:   int      				=	prot.atom_positions
    lowerCamelCase__					:   List[Any]      				=	prot.residue_index.astype(np.intaa				)
    lowerCamelCase__					:   Optional[int]      				=	prot.b_factors
    lowerCamelCase__					:   Any      				=	prot.chain_index

    if np.any(aatype > residue_constants.restype_num				):
        raise ValueError('Invalid aatypes.'				)

    lowerCamelCase__					:   List[Any]      				=	get_pdb_headers(_UpperCAmelCase				)
    if len(_UpperCAmelCase				) > 0:
        pdb_lines.extend(_UpperCAmelCase				)

    lowerCamelCase__					:   Union[str, Any]      				=	aatype.shape[0]
    lowerCamelCase__					:   Optional[Any]      				=	1
    lowerCamelCase__					:   str      				=	0
    lowerCamelCase__					:   Tuple      				=	string.ascii_uppercase
    lowerCamelCase__					:   str      				=	None
    # Add all atom sites.
    for i in range(_UpperCAmelCase				):
        lowerCamelCase__					:   List[Any]      				=	res_atoa(aatype[i]				)
        for atom_name, pos, mask, b_factor in zip(_UpperCAmelCase		,			atom_positions[i]		,			atom_mask[i]		,			b_factors[i]				):
            if mask < 0.5:
                continue

            lowerCamelCase__					:   Union[str, Any]      				=	'ATOM'
            lowerCamelCase__					:   Optional[int]      				=	atom_name if len(_UpperCAmelCase				) == 4 else F""" {atom_name}"""
            lowerCamelCase__					:   Any      				=	''
            lowerCamelCase__					:   Optional[Any]      				=	''
            lowerCamelCase__					:   str      				=	1.00
            lowerCamelCase__					:   str      				=	atom_name[0]  # Protein supports only C, N, O, S, this works.
            lowerCamelCase__					:   List[str]      				=	''

            lowerCamelCase__					:   str      				=	'A'
            if chain_index is not None:
                lowerCamelCase__					:   List[Any]      				=	chain_tags[chain_index[i]]

            # PDB is a columnar format, every space matters here!
            lowerCamelCase__					:   Union[str, Any]      				=	(
                F"""{record_type:<6}{atom_index:>5} {name:<4}{alt_loc:>1}"""
                F"""{res_name_a:>3} {chain_tag:>1}"""
                F"""{residue_index[i]:>4}{insertion_code:>1}   """
                F"""{pos[0]:>8.3f}{pos[1]:>8.3f}{pos[2]:>8.3f}"""
                F"""{occupancy:>6.2f}{b_factor:>6.2f}          """
                F"""{element:>2}{charge:>2}"""
            )
            pdb_lines.append(_UpperCAmelCase				)
            atom_index += 1

        lowerCamelCase__					:   Dict      				=	i == n - 1
        if chain_index is not None:
            if i != n - 1 and chain_index[i + 1] != prev_chain_index:
                lowerCamelCase__					:   List[Any]      				=	True
                lowerCamelCase__					:   List[str]      				=	chain_index[i + 1]

        if should_terminate:
            # Close the chain.
            lowerCamelCase__					:   int      				=	'TER'
            lowerCamelCase__					:   Any      				=	(
                F"""{chain_end:<6}{atom_index:>5}      {res_atoa(aatype[i]				):>3} {chain_tag:>1}{residue_index[i]:>4}"""
            )
            pdb_lines.append(_UpperCAmelCase				)
            atom_index += 1

            if i != n - 1:
                # "prev" is a misnomer here. This happens at the beginning of
                # each new chain.
                pdb_lines.extend(get_pdb_headers(_UpperCAmelCase		,			_UpperCAmelCase				)				)

    pdb_lines.append('END'				)
    pdb_lines.append(''				)
    return "\n".join(_UpperCAmelCase				)


def  SCREAMING_SNAKE_CASE   ( _UpperCAmelCase				)    ->  np.ndarray:
    return residue_constants.STANDARD_ATOM_MASK[prot.aatype]


def  SCREAMING_SNAKE_CASE   ( _UpperCAmelCase		,			_UpperCAmelCase		,			_UpperCAmelCase = None		,			_UpperCAmelCase = None		,			_UpperCAmelCase = None		,			_UpperCAmelCase = None		,			_UpperCAmelCase = None		,			)    ->  Protein:
    return Protein(
        aatype=features['aatype']		,			atom_positions=result['final_atom_positions']		,			atom_mask=result['final_atom_mask']		,			residue_index=features['residue_index'] + 1		,			b_factors=b_factors if b_factors is not None else np.zeros_like(result['final_atom_mask']				)		,			chain_index=_UpperCAmelCase		,			remark=_UpperCAmelCase		,			parents=_UpperCAmelCase		,			parents_chain_index=_UpperCAmelCase		,			)





