Title: Transverse Tubular System - an overview | ScienceDirect Topics
Headings: Transverse Tubular System
Transverse Tubular System
Cardiovascular Physiology
Transverse Tubules
Ion Channel Trafficking
T-Tubules
Functional Organization of Vertebrate Plasma Membrane
2.4 T-tubules, physiology, and disease
Skeletal Muscle
T-tubules Are Surface Invaginations; the SR Is an Internal Membrane System
Cardiac Rhythm
4.2.1 Ca++ Regulation
Cardiovascular Physiology
Membrane Depolarization and Activator Calcium
Structure and Function of Calcium Release Channels
2 T Tubules and CRUs Revert to More Primitive Forms Under Pathological Conditions
Ion Channel Trafficking in the Heart
Ca V 1.2 Channel Trafficking in the Heart
Ca V 1.2 Forward Trafficking in Normal Heart Physiology
Ca V 1.2 Forward Trafficking in Heart Pathophysiology
Accessory Proteins Involved in Ca V 1.2 Targeted Delivery
T-Tubules and Ca V 1.2 Regulation in Normal Heart Physiology
T-Tubules and Ca V 1.2 Regulation in Heart Pathophysiology
Ca V 1.2 Internalization
Muscles
Coupling Action Potentials to Contraction
Skeletal Muscle Excitability
AIII Further Evidence that the T-Tubules Fire Na + -Dependent AP s

Content: From their data, the authors proposed that the dysfunction was due to a gain in the CICR process, implicating T-tubule structural disorganization in the pathophysiology of the failing myocyte. Follow-up studies also demonstrated that failing myocytes have increased Ca 2 + spark frequency, consistent with an uncoupling of the Ca 2 + release machinery and disruption of the T-tubules. It has also been argued that such a mechanism would produce only transient/short-lived changes in the size of the Ca 2 + transient and that it is more likely that a decrease in SR Ca 2 + content underlies the decrease in Ca 2 + transients. However, a reduction in T-tubule density could desynchronize Ca 2 + following electric stimulation, reducing peak Ca 2 + and slowing the time course. Although the loss of T-tubules cannot be completely responsible for the changes in Ca 2 + handling observed in heart failure, it is important to note that many of the functional changes exhibited in heart failure are observed in detubulation experiments, suggesting that the loss of T-tubules in heart failure may contribute to or exacerbate the phenotype observed in models of heart failure. View chapter Purchase book
Read full chapter
URL: https://www.sciencedirect.com/science/article/pii/B9780124170278000040
Skeletal Muscle
Clara Franzini-Armstrong, Andrew G. Engel, in Muscle, 2012
T-tubules Are Surface Invaginations; the SR Is an Internal Membrane System
T-tubules have a random, mostly longitudinal, disposition between the myofibrils during their initial formation but even at this stage they immediately form junctions with SR elements. The mature position of T-tubules within planes perpendicular to the fiber long axis ( Figure 53.1A,B) is acquired gradually during the coordinated differentiation of myofibrils and membrane system. This reorientation takes up to a month in chick and mouse muscles and the association of the whole triad assembly with the appropriate myofibril location drives it, perhaps via ankyrin and the giant protein obscurin.