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Content: Clindamycin  is  the  most  commonly  used  prophylaxis  in preoperative  patients  who  have  a  penicillin  allergy  (13). Other  alternatives  depend  on  the  organism  and  area  of the  body. Commonly  used  alternatives  are  vancomycin, sulfamethoxazole/trimethoprim  (Bactrim),  doxycycline, clindamycin, linezolid, synercid, and levoﬂ oxacin (14-16). CHAPTER16
76  CHAPTER 16
SULFA DRUGS 
Sulfa drugs are any drugs containing sulfonamides. They are derivatives of para-amino benzoic acid (17). There are many groups of drugs that contain sulfa. Examples include antibiotics (sulfamethoxazole/trimethoprim), diuretics for high-blood  pressure  (hydrochlorothiazide,  furosemide), sulfonylureas for reducing blood sugar in diabetes mellitus (glyburide),  and  dapsone  for  leprosy  (18). Other  drugs containing sulfa include burn creams and eye drops. Drugs containing sulfa were one of the earliest drugs used against bacterial  infections. Antibiotic  derivatives  of  sulfa  drugs include  septrin,  gantanol,  and  bactrim.