Title: 
Headings: 

 
REVIEW
 
OF
 
ARSENIC
 
POISONING
 
AND
 
ITS
 
EFFECTS
 
ON
 
HUMAN
 
HEALTH
 

I.
 
INTRODUCTION
 

II.
 
SOURCE
 
OF
 
EXPOSURE
 

III.
 
ARSENIC
 
POISONING
 

A.
 
Acute
 
Poisoning:
 

B.
 
Chronic
 
Poisoning:
  

IV.
 
PRIMARY
 
SYMPTOMS
 
AND
 
DIAGNOSIS
 
OF
 
ARSENIC
 
DISEASES
  

Clinical
 
Symptoms:
 

Stages
 
of
 
Clinical
 
Features
 
of
 
Arsenic
 
Toxicity
 

Major
 
Dermatological
 
Signs:
 

(vii)
 
Combination
 
of
 
pigmentation
 
(Melanosis)
 
and
 
nodular
 
rough
 
skin
 
(spotted
 
palmoplanter
 

Minor
 
Dermatological
 
Feature:
 

Other
 
Rare
 
Signs:
 

V.
 
TOXICITY
 
OF
 
ARSENIC
 
TO
 
HUMANS
  

A.
 
Respiratory
 
Effects:
 

B.
 
Cardiovascular
 
Effects:
  

C.
 
Gastrointestinal
 
Effect:
  

D.
 
Hematological
 
Effects:
  

E.
 
Hepatic
 
Effect:
 

F.
 
Renal
 
Effects:
 

G.
 
Dermal
 
Effects:
 

H.
 
Neurological
 
Effects:
 

I.
 
Developmental
 
Effects
 

J.
 
Reproductive
 
Effects
 

K.
 
Genotoxicity
 
Effects
 

L.
 
Mutagenic
 
Effects:
   

M.
 
Immunologic
 
Effect:
 

N.
 
Carcinogenic
 
Effect:
 

O.
 
Cancer
 
of
 
the
 
Respiratory
 
System:
 

P.
 
Cancer
 
of
 
the
 
Skin:
 

Q.
 
Biochemical
 
Effects
 

VI.
 
TRANSFORMATION
 
OF
 
ARSENIC
 
IN
 
THE
 
BODY
 

VII.
 
HOW
 
ARSENIC
 
AFFECT
 
OR
 
DESTROY
 
THE
 
BODY
 
ENZYMATIC
 
SYSTEM
 

1st
 
step.
 

Step
 
2
 

VIII.
 
REMEDY
 
FOR
 
ARSENICOSIS
 


 
Acute
 
Arsenic
 
Poisoning
 

B.
 
Chronic
 
Arsenic
 
Poisoning
 

IX.
 
PREVENTION
 
OF
 
ARSENIC
 
POISONING
 
IN
 
HUMANS
 

X.
 
CONCLUSIONS
 

Increasing
 
incidence
 
of
 
arsenicosis-cumulative
 
(1983-97)
 

REFERENCES
 


Content: though
 
it
 
can
 
prevent
 
further
 
complication. Once
 
the
  
___________________________________________________________________________
 
4Address
 
correspondence
 
to
 
Dr.
 
K.
 
C.
 
Saha,
 
EC-21,
 
Sector
 
1,
 
Salt
 
Lake,
 
Calcutta-700064,
 
India
 
complication
 
(malignancy)
 
has
 
developed,
 
using
 
medicine
 
may
 
not
 
prevent
 
it. The
 
symptoms
 
and
  
signs
 
of
 
arsenic
 
poisoning
 
may
 
be
 
reduced
 
if
 
the
 
quality
 
of
 
drinking
 
water
 
were
 
improved. Arsenic
 
free
 
water
 
or
 
decrease
 
in
 
arsenic
 
level
 
in
 
the
 
drinking
 
water
 
source
 
is
 
essential
 
for
 
overall
 
development. KEY
 
WORDS: Arsenicosis,
 
acute
 
toxicity,
 
chronic
 
toxicity,
 
melanosis,
 
keratosis,
 
cancer,
 
ground
 
water,
 
remedy. I.
 
INTRODUCTION
 
Arsenic
 
is
 
an
 
element
 
that
 
raises
 
much
 
concern
 
from
 
the
 
both
 
environmental
 
and
 
human
 
health
 
standpoints. Humans
 
may
 
encounter
 
arsenic
 
in
 
water
 
from
 
wells
 
drilled
 
into
 
arsenic-rich
 
ground
 
strata
 
or
 
in
 
water
 
contaminated
 
by
 
industrial
 
or
 
agrochemical
 
waste.62
 
They
 
may
 
come
 
in
 
contact
 
with
 
arsenic
 
in
 
contaminated
 
dusts,
 
fumes,
 
or
 
mists. They
 
may
 
eat
 
food
 
contaminated
 
with
 
arsenical
 
pesticides
 
or
 
grown
 
with
 
arsenic-contaminated
 
water
 
or
 
in
 
arsenic-rich
 
soil.99
 
In
 
experience
 
of
 
one
 
of
 
us
 
(KCS)
 
food
 
grown
 
in
 
arsenic
 
affected
 
areas
 
arsenic
 
is
 
not
 
found
 
inside
 
the
 
food
 
like
 
cereals,
 
pulses,
 
fruits,
 
but
 
may
 
be
 
found
 
in
 
external
 
layer
 
of
 
food
 
or
 
fruits
 
due
 
to
 
spreneld
 
of
 
arsenicated
 
water. Similarly
 
milk
 
of
 
arsenic
 
affected
 
cows
 
is
 
free
 
from
 
arsenic
 
due
 
to
 
modification
 
inside
 
body
 
or
 
some
 
barrier
 
action
 
of
 
unknown
 
mechanism.