Title: 8 Health Benefits of Magnolia Bark + Dosage, Side Effects - SelfHacked
Headings: 8 Health Benefits of Magnolia Bark + Dosage, Side Effects
8 Health Benefits of Magnolia Bark + Dosage, Side Effects
What Is Magnolia Tree/Bark?
Components
Mechanism of Action
Snapshot
Proponents
Skeptics
Health Benefits
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Possibly Effective for:
1) Oral Health
2) Menopausal Symptoms
3) Anxiety
4) Depression
5) Insomnia
Insufficient Evidence for:
1) Asthma
2) Fatty Liver
3) Weight Loss
Animal and Cell Research (Lack of Evidence)
Brain Function
Inflammation and Pain
Diabetes
Seizures
High Blood Pressure
Enlarged Prostate
Cancer
Limitations & Caveats
Side Effects & Precautions
Side Effects
Contraindications
Drug Interactions
Supplementation
Dosage
User Experiences
Are you stressed out?

Content: During the summer, the root and bark from the trees are harvested, dried, slightly boiled, and let to turn a purple-brown color. After being softened by steaming and rolling, this bitter and fragrant extract is used in medicine and dietary supplements for its potential health benefits [ 1 ]. Magnolia bark extract is often used in combination with Phellodendron bark extract in a supplement called Relora that is used for anxiety [ 2, 1 ]. Components
Magnolol and honokiol are lignans that are the major active components of magnolia bark extract. Various alkaloids (aporphine and benzylisoquinoline derivatives) and volatile oils (consisting of sesquiterpenoid alcohols, α-, β-, and γ-eudesmol) make up the rest of the extract [ 1 ]. Mechanism of Action
Honokiol maintains sodium- potassium channel activity, which is vital for communications between neurons [ 3 ]. Honokiol prevents glucose intolerance, which otherwise would severely damage neuron cells because they require a high amount of energy to function [ 4 ]. Honokiol also prevented the formation of necrotic tissue in rat brains by stopping neutrophil (immune cells that kill damaged cells and harmful pathogens) activity and neutralizing reactive oxygen species such as hydrogen peroxide [ 4 ]. Honokiol prevents neurotoxicity by inhibiting the production of nitric oxide by an enzyme called nNOS. This enzyme depends on calcium, which is allowed into cells by a glutamate (a neurotransmitter) receptor called the NMDA receptor.