Title: T-tubule | Psychology Wiki | Fandom
Headings: T-tubule
T-tubule
Contents
Structure
Excitation-contraction coupling
Detubulation
See also
External links

Content: Detubulation
It is possible to physically and functionally uncouple T-tubules from the surface membrane using a technique known as detubulation. This relies on osmotically active chemicals, such as glycerol (for skeletal muscle) or formamide (mainly for cardiac muscle ). Addition of these chemicals to the solution surrounding muscle cells causes the cells to shrink; when the chemical is withdrawn the cells rapidly expand before returning to their normal size. The rapid expansion is thought to cause the t-tubules to detach from the surface membrane, which reseals, and to reseal within the cell. This technique can be used to investigate the function of the t-tubules. There is some evidence that heart failure precipitates the loss of the T-tubule network, again indicating their importance. [ How to reference and link to summary or text]
See also
Muscle contraction
External links
Histology at Boston University 22502loa - "Ultrastructure of the Cell: cardiac muscle, intercalated disk "
Dictionary at eMedicine T+tubule
Physiology at MCG 2/2ch3/communic
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