Title: Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years | Rheumatology | Oxford Academic
Headings: Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years
Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years
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Abstract
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Issue Section:
Methods
Results ( Table 1)
Patient demographics
Associations
Concomitant drugs
Dosing issues
Severity of pancytopenia
Discussion
References
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Content: died
9
78/M
12.5 mg, 11 months oral (severe)
Blood monitoring, epistaxis
Low folate renal impairment
Nizatidine, indoramin, diltiazem, Asasantin Retard, prochlorperazine, metoclopramide
Blood transfusion folinic acid; recovered
10
24/F
20 mg, 24 months oral (severe)
Epistaxis, PV bleed, purpura
Hepatic steatosis, anorexia, low albumin
Folic acid, loratidine, prednisolone, alendronate, coproxamol
Folinic acid; recovered
11
83/F
7.5 mg, 36 months s.c. ( not severe)
Mucositis, epistaxis, foll pamidronate
Low albumin glomerulo-nephritis
Atenolol, coamilofruse, doxazosin, folic acid, amlodipine
Folinic acid; recovered
12
84/F
10 mg, 48 months oral (not severe)
Blood monitoring
Raised MCV
Nifedipine, folic acid, meloxicam, frusemide
Recovered
13
69/M
12.5 mg, 47 months oral (not severe)
Mucositis, epistaxis sepsis
Renal impairment, low albumin, Septrin
Folic acid, Septrin, prednisolone, risedronate, atenolol, felodipine
Folinic acid, blood transfusion; recovered
14
83/F
10 mg, 93 months oral (not severe)
Angina
Low albumin
Folic acid, frusemide, alendronate
Folinic acid, AML; died
15
61/F
20 mg, 60 months oral (severe)
Epistaxis, mucositis, cellulitis
Raised MCV, low albumin, daily MTX
Risedronate, Calcichew, pantoprazole
Folinic acid; recovered
16
68/F
12.5 mg, 24 months oral (not severe)
Blood monitoring
Raised MCV, low albumin
Premarin, aspirin
Recovered
17
82/F
12.5 mg, 120 months oral (not severe)
Mucositis
Low folate
Lisinopril, digoxin, amiodarone, frusemide, lansoprazole, Calcichew, alendronate, iron
Recovered
18
82/F
10 mg, 87months s.c. ( severe)
Sepsis, pneumonia
Renal impairment, low albumin
Perindopril, frusemide
Blood transfusion folinic acid; recovered
19
82/F
10 mg, 78 months oral (not severe)
Sepsis
Low albumin, raised MCV, renal impairment
Prednisolone, celecoxib, alendronate, lisinopril, bendrofluazide
Folinic acid;