Title: Progressive Systemic Sclerosis - an overview | ScienceDirect Topics
Headings: Progressive Systemic Sclerosis
Progressive Systemic Sclerosis
NEUROLOGY OF RHEUMATOLOGY, IMMUNOLOGY, AND TRANSPLANTATION
PROGRESSIVE SYSTEMIC SCLEROSIS
Epigenetic Basis of Autoimmune Disorders in Humans
11.2.6 Epigenetic Deregulation in Progressive Systemic Sclerosis
Autoimmune and Inflammatory Disorders
PATHOGENESIS AND PATHOPHYSIOLOGY
The Pharmacology and Therapeutic Aspects of Colchicine
F PROGRESSIVE SYSTEMIC SCLEROSIS
Disturbances of Gastrointestinal Motility and the Nervous System
General Muscle Diseases Causing Gut Dysmotility
OCCUPATIONAL DISEASES | Coal Workers’ Pneumoconiosis
Autoimmune diseases
Autoimmune Disease
IgG Anti-RNA Polymerase III (ARA)
Reference Interval
Clinical Applications
Limitations
Assay Technology
Type of Sample
Maternal Antibodies
Nonorgan-specific autoimmune diseases

Content: In progressive systemic sclerosis, the skin is affected in a number of other ways, including calcifications, telangiectasias, finger swelling, and sclerodactyly (tightening of the skin of the digits). Raynaud's phenomenon occurs in as many as 90% of patients with progressive systemic sclerosis. Other systemic manifestations are gastrointestinal disease, especially impaired esophageal motility; pulmonary disease, such as fibrosis or pulmonary hypertension; renal or cardiac involvement, especially with hypertension; hypothyroidism; sicca syndrome; and arthralgias and tenosynovitis. Dysphagia is often present because of esophageal disease and is usually not an indication of bulbar neurological dysfunction. The syndrome of subcutaneous calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia (CREST) may be present with less systemic involvement.