Title: Sulfanilamide | drug | Britannica
Headings: Sulfanilamide
Sulfanilamide
drug
Learn about this topic in these articles:
antibiotic development
antimetabolites
carboxylic acids
medicinal applications
organosulfur compounds
sulfa drugs

Content: Thus, the enzymes are inhibited from catalyzing the synthesis of folic acid and, deprived of folic…
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medicinal applications
In protein: Inhibition of enzymes
The inhibitor sulfanilamide, for example, is similar enough to a substrate ( p -aminobenzoic acid) of an enzyme involved in the metabolism of folic acid that it binds to the enzyme but cannot react. It covers the active site and prevents the binding of p -aminobenzoic acid. This enzyme is…
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In history of medicine: Sulfonamide drugs
…its active antibacterial agent is sulfanilamide. In 1936 English physician Leonard Colebrook and colleagues provided overwhelming evidence of the efficacy of both Prontosil and sulfanilamide in streptococcal septicemia (bloodstream infection), thereby ushering in the sulfonamide era. New sulfonamides, which appeared with astonishing rapidity, had greater potency, wider antibacterial range, or…
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organosulfur compounds
In organosulfur compound: Other sulfinyl and sulfonyl compounds
Sulfanilamide, p -aminobenzenesulfonamide, a compound used in the manufacture of azo dyes, was found to inhibit the growth of bacteria. This discovery led to the development of sulfa drugs, which still find some use today in the treatment of infections, although they have been largely replaced…
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sulfa drugs
In sulfa drug
…of synthetic antibiotics containing the sulfanilamide molecular structure. Sulfa drugs were the first chemical substances systematically used to treat and prevent bacterial infections in humans.