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Content: It’s sometimes called CREST syndrome, after its five common signs: Calcinosis. This is when calcium salts form nodules under your skin or in your organs. Raynaud’s phenomenon. This is a lack of blood flow to parts of your body such as your fingers, toes, or nose, usually because of cold. Your skin might turn red, white, or blue. Esophageal dysfunction. This is when your esophagus doesn’t work the way it should. Sclerodactyly. This is when your skin becomes thin and shiny.