Title: Gastrointestinal Motility Disorder - an overview | ScienceDirect Topics
Headings: Gastrointestinal Motility Disorder
Gastrointestinal Motility Disorder
Motility Disorders of the Stomach and Small Intestine
Abstract
Intestinal and Multivisceral Transplantation
Motility Disorders
Neurogastroenterology and motility disorders in pediatric population
Summary
Complications of Diabetes Mellitus
Gastropathy.
Disturbances of Gastrointestinal Motility and the Nervous System
Disorders of Gastrointestinal Motility
Pathobiology
Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children With Complex Airway Disease
Abstract
Neurobiology of the Enteric Nervous System
Sphincteric Achalasia

Content: Combined disorders occur in systemic sclerosis (Chapter 275), amyloidosis (Chapter 194), and mitochondrial cytopathy (Chapter 429), which initially can manifest with neuropathic patterns and later display myopathic characteristics with disease progression. Genetic defects that result in congenital dysmotilities include abnormalities of RET, the gene that encodes the tyrosine kinase receptor, and abnormalities in the endothelin B system. Neural crest cells migrate from the vagal and sacral crest to the developing gut and, over time, colonize the entire alimentary canal and its appendages. Endothelin B serves to retard maturation of migrating neural crest cells, thus facilitating colonization of the entire gut with nerve cells. Other abnormalities resulting in congenital dysmotility involve other transcription factors, such as Sox10, which enhances maturation of neural precursors, and KIT, a marker for the interstitial cells of Cajal. Defects of RET, endothelin B, and Sox10 are associated with the phenotypic picture recognized as Hirschsprung's disease, whereas KIT defects have been associated with idiopathic hypertrophic pyloric stenosis and congenital megacolon. View chapter Purchase book
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URL: https://www.sciencedirect.com/science/article/pii/B978143771604700138X
Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children With Complex Airway Disease
Scott Pentiuk MD, MEd, Philip E. Putnam MD, in Kendig's Disorders of the Respiratory Tract in Children (Ninth Edition), 2019
Abstract
Gastroesophageal reflux disease (GERD), gastrointestinal dysmotility, and Eosinophilic Esophagitis (EoE) are all entities which can affect children with complex airway conditions. GERD is defined as symptoms or mucosal changes related to stomach acid regurgitation. It has been implicated in airway symptoms such as chronic cough and swallowing difficulty outside of “classic” reflux complaints of heartburn.