Title: CMA - Clinical: Centromere Antibodies, IgG, Serum
Headings: Test ID: CMA
Centromere Antibodies, IgG, Serum

Test ID: CMA
Centromere Antibodies, IgG, Serum
Useful For
Suggests clinical disorders or settings where the test may be helpful
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Interpretation
Provides information to assist in interpretation of the test results
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Clinical Reference
Recommendations for in-depth reading of a clinical nature
Special Instructions
Library of PDFs including pertinent information and forms related to the test

Content: +1 855-379-3115
Values are valid only on day of printing. Test ID: CMA
Centromere Antibodies, IgG, Serum
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Overview
Specimen
Clinical & Interpretive
Performance
Fees & Codes
Setup & Updates
Useful For
Suggests clinical disorders or settings where the test may be helpful
Evaluating patients with clinical signs and symptoms compatible with systemic sclerosis including skin involvement, Raynaud phenomenon, and arthralgias
Aiding in the diagnosis of calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis (CREST) syndrome
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests. See Connective Tissue Disease Cascade (CTDC) in Special Instructions. Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Centromere antibodies occur primarily in patients with the calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis (CREST) syndrome variant of systemic sclerosis (scleroderma). CREST syndrome is characterized by the following clinical features: calcinosis, Raynaud phenomenon, esophageal hypomotility, sclerodactyly, and telangiectasia. ( 1) Centromere antibodies were originally detected by their distinctive pattern of fine-speckled nuclear staining on cell substrates used in the fluorescent antinuclear antibody test. ( 2) In subsequent studies, centromere antibodies were found to react with several centromere proteins of 18 kDa, 80 kDa, and 140 kDa named as CENP-A, CENP-B, and CENP-C, respectively. (