Title: Susceptibility of urine isolates of Staphylococcus saprophyticus to antimicrobial agents - ScienceDirect
Headings: 
Pathology
Susceptibility of urine isolates of Staphylococcus saprophyticus to antimicrobial agents
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Content: 3 ,6 -8 .1 I , 12 suphrophyticus may ha rbor plasmids encoding antimicrobial resistance12 and beta-lactamase activity has been observed in some clinical isolate^.^,'^ Because of the importance of Staph. saprophyticus as a urinary pathogen, empirical therapy should be chosen to include an antibiotic active against this organism. The purpose of this study was to determine the susceptibility of Staph. saprophyticus to a selection of antimicrobial agents likely to be used in the therapy of community- acquired urinary tract infections. MATERIALS AND METHODS Isolures All isolates of Stuph. suprophytrcu.r were cultured from urine specimens, from symptomatic patients, submitted to a large private pathology laboratory. All catalase-positive, coagulase-negative, Gram positive cocci were initially screened for novobiocin ( 5 pg disc) s ~ s c e p t i b i l i t y ~~ and later identified using the classification scheme of Kloos and Schleifer,IS as incorporated in the API STAPH (API System, La Balme Les Grottes 38390, Montalieu Vercieu, France) micromethod. Isolates were stored frozen at ~ 10Â°C in Tryptic soy broth (Oxoid, Basingstoke. UK) with 10% glycerol until tested. A total of 96 strains of Stuph.