Title: 
Headings: Arsenic (As) and Inorganic Arsenic Compounds
Arsenic
 
(As)
 
and
 
Inorganic
 
Arsenic
 
Compounds
 

Description

Routes
 
of
 
Exposure

Dermal
  

Physical
 
Properties

Incompatibilities

Health
 
Effects
 

Acute
 
Exposure

Cardiovascular
  

Chronic
 
Exposure

Prehospital
 
Management
 

Hot
 
Zone

Decontamination
 
Zone

Support
 
Zone

Multi-Casualty
 
Triage

Emergency
 
Department
 
Management
 

Reporting

Arsenic
 
trioxide
 
(As2O3)
 
Patient
 
Information
 
Sheet
 

What
 
is
 
arsenic
 
trioxide?
 

What
 
immediate
 
health
 
effects
 
can
 
be
 
caused
 
by
 
exposure
 
to
 
arsenic
 
trioxide?
 

Can
 
arsenic
 
trioxide
 
poisoning
 
be
 
treated?
 

Are
 
any
 
future
 
health
 
effects
 
likely
 
to
 
occur?
 

What
 
tests
 
can
 
be
 
done
 
if
 
a
 
person
 
is
 
exposed
 
to
 
arsenic
 
trioxide?
 

Where
 
can
 
more
 
information
 
about
 
arsenic
 
trioxide
 
be
 
found?
 

Follow-up
 
Instructions
 

References
 


Content: Symptoms
 
are
 
dose
 
dependent
 
and
 
can
 
be
 
delayed. Similar
 
effects
 
would
 
be
 
expected
 
following
 
oral
 
exposure
 
to
 
toxic
 
levels
 
of
 
other
 
arsenic
 
compounds. Dermal
 
contact
 
and
 
inhalation
 
of
 
airborne
 
arsenic
 
trioxide
 
and
 
other
 
arsenic
 
compounds
 
may
 
cause
 
localized
 
irritation,
 
but
 
usually
 
do
 
not
 
result
 
in
 
systemic
 
effects. Acute
 
Exposure
The
 
toxic
 
effects
 
caused
 
by
 
acute
 
exposure
 
to
 
arsenic
 
are
 
due
 
in
 
large
 
part
 
to
 
its
 
inhibition
 
of
 
pyruvate
 
and
 
succinate
 
oxidation,
 
which
 
leads
 
to
 
decreased
 
production
 
of
 
acetyl-CoA
 
and
 
succinyl-CoA,
 
impaired
 
gluconeogenesis,
 
and
 
disruption
 
of
 
oxidative
 
phosphorylation. Arsenic
 
accumulates
 
in
 
mitochondria
 
and
 
damages
 
mitochondrial
 
membranes. As(V)
 
mimics
 
phosphate
 
anions,
 
which
 
leads
 
to
 
loss
 
of
 
high-energy
 
phosphate
 
bonds,
 
uncoupling
 
of
 
ATP
 
synthesis,
 
and
 
decreased
 
mitochondrial
 
respiration. The
 
primary
 
target
 
organs
 
are
 
the
 
gastrointestinal
 
tract,
 
heart,
 
brain,
 
and
 
kidney. Eventually
 
the
 
skin,
 
bone
 
marrow,
 
a