Title: Anti-Centromere Antibodies - an overview | ScienceDirect Topics
Headings: Anti-Centromere Antibodies
Anti-Centromere Antibodies
AUTOIMMUNITY AND THE MUSCULOSKELETAL SYSTEM
Anti-centromere pattern
Sjögren's syndrome
Classification and diagnosis
Key points
ANTI-RNA POLYMERASE III ANTIBODIES
Disease Prevalence
Cholestatic Diseases, Chronic
Serologic Diagnosis
TOPOISOMERASE-I (SCL-70) AUTOANTIBODIES
Disease Association
Autoimmune disease
General management
Microtubules: in vivo
2 Procedure
Systemic Sclerosis
Vascular Damage
Immune Activation
Fibrosis
Thromboangiitis Obliterans (Buerger's Disease)
Laboratory and Arteriographic Findings
Thrombotic Microangiopathies
Clinical and Laboratory Manifestations

Content: Anti-Centromere Antibodies - an overview | ScienceDirect Topics
Anti-Centromere Antibodies
ACA are found in systemic sclerosis in its limited cutaneous form and in the Calcinosis, Raynaud's phenomenon, Esophageal disease, Sclerodactyly, Teleangectasia syndrome variant. From: Seminars in Arthritis and Rheumatism, 2010
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AUTOIMMUNITY AND THE MUSCULOSKELETAL SYSTEM
Nicholas Manolios, in The Musculoskeletal System (Second Edition), 2010
Anti-centromere pattern
This specific speckled pattern is due to antibodies to the centromere and results in exactly 46 nuclear speckles. Anti-centromere antibodies are associated with the CREST syndrome, a limited variant of the disease scleroderma. The latter is also known as systemic sclerosis. CREST comprises C for calcinosis (calcium hydroxyapatite deposition in soft tissues), R for Raynaud’s phenomenon (abnormal vascular sensitivity of the digits on exposure to cold, characterized by a classical three-phase colour change of white, then blue, then red), E for esophageal dysfunction (usually manifest initially as difficulty swallowing), S for sclerodactyly (thickening of the skin of the digits) and T for telangiectasia (localized capillary dilatation and tortuosity in the skin). Anti-centromere antibody is uncommon in the more diffuse form of systemic sclerosis and is only rarely found in other connective tissue disorders. View chapter Purchase book
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URL: https://www.sciencedirect.com/science/article/pii/B9780702033773000093
Sjögren's syndrome
Robert I. Fox MD, PhD, Carla M. Fox RN, in Sjogren's Syndrome, 2020
Classification and diagnosis
In the “present” section of this introductory chapter, an important advance to emphasize is the recent improvements in the classification criteria for SS 51 that are necessary for basic research, clinical trials by industry, and designation of endpoints by FDA regulators. These criteria and the guidelines for diagnostic testing suggested by both the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) are the subjects of Chapter 2 in this book.