Title: Magnolia Bark Extract: Benefits, Side Effects & Dosage
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Content: However, honokiol has fewer motor and cognitive side effects than traditional anxiety medications, such as Xanax and Klonopin. Thus, honokiol is more selective in the receptors it binds to, which enables it to produce a similar anxiolytic effect with fewer detrimental side effects. One particular study found that an active dose as small as 0.2 mg/kg can possibly significantly increase exploratory behavior and decrease anxiety-related behavior in animal models. The same study also found that honokiol is effective at combating the anxiety-producing effects of large doses of caffeine ( x ). Additionally, studies show that a blend of honokiol and magnolol may reduce corticosterone concentration in the brain, which is associated with symptoms of depression ( x ). Medical researchers found that in mice studies, honokiol increases GABA neurotransmitter synthesis in the hippocampal regions in the brain ( x ). However, there are no studies on human subjects. Studies suggest that honokiol’s neuroprotective properties make it a viable candidate for treating neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Menopause Symptoms
Researchers have also expressed magnolia extract’s potential as an effective management tool for menopause symptoms in women. One study demonstrated that a nutraceutical cocktail with magnolia extract significantly reduced the occurrence and severity of postmenopausal hot flashes and contributed to better sleep and psychophysical wellness in individuals compared to control groups ( x ).