Title: The science behind munchies: cannabis and your appetite | Examine.com
Headings: The science behind munchies: cannabis and your appetite
The science behind munchies: cannabis and your appetite
Tetrahydrocannabinol (THC), a cannabinoid in cannabis, can bind the cannabinoid receptor type 1 (CB1) and thus promote overeating and weight gain. This effect, detrimental to most people, can prove beneficial under certain medical conditions, such as cancer and HIV-associated wasting syndrome.
How cannabis works
Does cannabis cause weight gain?
Cannabis for weight gain in clinical populations
HIV-associated wasting syndrome
Cancer-associated cachexia
Anorexia nervosa
CB1: the key to weight loss?
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References

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But what exactly is cannabis and how does it affect appetite? Let’s dig in. How cannabis works
The word “cannabis” refers to several plants in the Cannabis genus, including sativa, indica, and ruderalis. The cannabinoid compound tetrahydrocannabinol (THC), one of cannabis main active ingredients, is also the main reason why cannabis can cause “the munchies”: by partially binding to and thus activating cannabinoid receptor type 1 (CB1), THC increases your appetite. In the different body tissues it occupies, CB1 acts in slightly different ways, several of which increase appetite. [ 2] CB1 can be found in the following areas: The basal ganglia, where it may enhance eating pleasure. The limbic forebrain, where it may enhance food palatability. The stomach and small intestine, which both regulate ghrelin (an appetite-stimulating hormone that speeds digestion).