Title: Type 2 diabetes in adolescents and young adults - The Lancet Diabetes & Endocrinology
Headings: Type 2 diabetes in adolescents and young adults
Type 2 diabetes in adolescents and young adults
Summary
Introduction
Epidemiology
Pathophysiology
Decline in β-cell function
Obesity-induced mechanisms
Key drivers for the development of type 2 diabetes in young people
Early life determinants
Diet and obesity
Physical activity
Socioeconomic factors
Family history
Female sex and polycystic ovarian syndrome
Non-alcoholic fatty liver disease
Clinical characteristics
Complications
Microvascular complications
Macrovascular complications
Other complications
Treatment
Lifestyle changes
Pharmacological and surgical approaches
Table 2 Key studies showing the effectiveness of interventions to treat young-onset type 2 diabetes
Societal effects of type 2 diabetes in young people
Summary and future research directions
Search strategy and selection criteria
Contributors
Declaration of interests
References
Article Info
Publication History
Identification
Copyright
ScienceDirect
Figures
Tables

Content: 2014; 311: 1778-1786
Crossref
PubMed
Scopus (341)
Google Scholar
Recent data from the SEARCH study (a multicentre, observational study in the USA involving 11 245 young people with type 1 diabetes [0–19 years] and 2846 with type 2 diabetes [10–19 years]),
6
Mayer-Davis EJ
Lawrence JM
Dabelea D
et al. for the SEARCH for Diabetes in Youth Study
Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med. 2017; 376: 1419-1429
Crossref
PubMed
Scopus (21)
Google Scholar
showed an annual increase of about 7% in the incidence of type 2 diabetes between 2002–03 and 2011–12 (from nine cases per 100 000 to 12·5 cases per 100 000) among people aged 10–19 years in the USA, with substantial relative increases in all ethnic minority groups compared with non-Hispanic white people. In a nationwide screening programme
7
Pinhas-Hamiel O
Zeitler P
The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr.