Title: Progressive Systemic Sclerosis - an overview | ScienceDirect Topics
Headings: Progressive Systemic Sclerosis
Progressive Systemic Sclerosis
NEUROLOGY OF RHEUMATOLOGY, IMMUNOLOGY, AND TRANSPLANTATION
PROGRESSIVE SYSTEMIC SCLEROSIS
Epigenetic Basis of Autoimmune Disorders in Humans
11.2.6 Epigenetic Deregulation in Progressive Systemic Sclerosis
Autoimmune and Inflammatory Disorders
PATHOGENESIS AND PATHOPHYSIOLOGY
The Pharmacology and Therapeutic Aspects of Colchicine
F PROGRESSIVE SYSTEMIC SCLEROSIS
Disturbances of Gastrointestinal Motility and the Nervous System
General Muscle Diseases Causing Gut Dysmotility
OCCUPATIONAL DISEASES | Coal Workers’ Pneumoconiosis
Autoimmune diseases
Autoimmune Disease
IgG Anti-RNA Polymerase III (ARA)
Reference Interval
Clinical Applications
Limitations
Assay Technology
Type of Sample
Maternal Antibodies
Nonorgan-specific autoimmune diseases

Content: hypothyroidism; sicca syndrome; and arthralgias and tenosynovitis. Dysphagia is often present because of esophageal disease and is usually not an indication of bulbar neurological dysfunction. The syndrome of subcutaneous calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia (CREST) may be present with less systemic involvement. More than half the patients with progressive systemic sclerosis have evidence of autoimmunity such as antinuclear antibodies or, less common but more specific, antibodies against centromeres, topoisomerase I, RNA polymerase III, or Scl-70. These provide some prognostic clues: anti–SCL-70 antibody is more often associated with fully developed progressive systemic sclerosis, whereas anticentromere antibodies are associated with CREST. Neurological complications are relatively limited in patients with progressive systemic sclerosis. These include headache, myopathy, trigeminal neuropathy, peripheral neuropathy, autonomic neuropathy, ectopic calcifications, and stroke.