Title: CREST Syndrome: Background, Pathophysiology, Etiology
Headings: CREST Syndrome
CREST Syndrome
Background

Content: CREST Syndrome: Background, Pathophysiology, Etiology
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Drugs & Diseases > Dermatology
CREST Syndrome
Updated: Oct 05, 2020
Author: Jeanie C Yoon, MD; Chief Editor: Dirk M Elston, MD more...
Sections
CREST Syndrome
Sections CREST Syndrome
Overview
Background
Pathophysiology
Etiology
Epidemiology
Prognosis
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Presentation
History
Physical Examination
Complications
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DDx
Workup
Laboratory Studies
Imaging Studies
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Treatment
Medical Care
Surgical Care
Consultations
Diet
Activity
Prevention
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Medication
Medication Summary
Calcium channel blockers
Prostaglandins
Antidepressants
Phosphodiesterase enzyme inhibitors
Histamine H2 antagonists
Proton-pump inhibitors
Antihypertensive agents
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Questions & Answers
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References
Overview
Background
CREST ( calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome is a member of the heterogeneous group of sclerodermas, and its name is an acronym for the cardinal clinical features of the syndrome. [ 1, 2]
In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calcinosis cutis, Raynaud phenomenon, sclerodactyly, and telangiectasia) syndrome in English by Winterbauer who, in 1964, described a series of 8 patients with the features that make up the abbreviation CRST. [ 3, 4] Although he noted esophageal dysmotility in 4 of 8 patients, he did not include this feature in his original description of CRST syndrome.