Title: T-Tubule Function in Mammalian Cardiac Myocytes | Circulation Research
Headings: T-Tubule Function in Mammalian Cardiac Myocytes
T-Tubule Function in Mammalian Cardiac Myocytes
Abstract
Occurrence and Morphology of the T-Tubules
T-Tubule Development Is Labile
Proteins Present in the T-Tubule Membrane
Ca2+-Handling Proteins
Na+-Handling Proteins
K+-Handling Proteins
Anion-Handling Proteins
Second-Messenger Pathways
Interpretation of Immunohistochemical Data
Protein Colocalization Within, and With Proteins Adjacent to, the T-Tubules
Localization of Function
Cells Lacking T-Tubules
Diffusion Studies
Scanning Pipette
Detubulation
Functional Role
Electrical Properties of T-Tubules
Coupling of Ca 2+ Entry and Ca 2+ Release
Ca 2+ Efflux
Signal Transduction
Changes During Development and Disease
T-Tubule Development and Morphology in Hypertrophy and Failure
Changes in Protein Expression in Development, Hypertrophy, and Failure
Relevance of Changes in T-Tubule Structure and Protein Expression to Function
Conclusions and Unanswered Questions
Footnotes
References

Content: T-Tubule Function in Mammalian Cardiac Myocytes | Circulation Research
Home Circulation Research Vol. 92, No. 11 T-Tubule Function in Mammalian Cardiac Myocytes
T-Tubule Function in Mammalian Cardiac Myocytes
Fabien Brette
and
Clive Orchard
Fabien Brette
Fabien Brette From the School of Biomedical Sciences, University of Leeds, Leeds, UK. Search for more papers by this author
and
Clive Orchard
Clive Orchard From the School of Biomedical Sciences, University of Leeds, Leeds, UK. Search for more papers by this author
Originally published 13 Jun 2003 https://doi.org/10.1161/01.RES.0000074908.17214.FD Circulation Research. 2003;92:1182–1192
Abstract
The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent studies have suggested that the structure and function of the t-tubules are more complex than previously believed; in particular, many of the proteins involved in cellular Ca 2+ cycling appear to be concentrated at the t-tubule. Thus, the t-tubules are an important determinant of cardiac cell function, especially as the main site of excitation-contraction coupling, ensuring spatially and temporally synchronous Ca 2+ release throughout the cell. Changes in t-tubule structure and protein expression occur during development and in heart failure, so that changes in the t-tubules may contribute to the functional changes observed in these conditions.