Title: CREST syndrome - Wikipedia
Headings: CREST syndrome
CREST syndrome
Contents
Signs and symptoms
Calcinosis
Raynaud's phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasias
Other
Cause
Diagnosis
Treatment
Epidemiology
History
See also
References
External links

Content: The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. CREST syndrome is associated with detectable antibodies against centromeres (a component of the cell nucleus ), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma ). If the lungs are involved, it is usually in the form of pulmonary arterial hypertension . Contents
1 Signs and symptoms
1.1 Calcinosis
1.2 Raynaud's phenomenon
1.3 Esophageal dysmotility
1.4 Sclerodactyly
1.5 Telangiectasias
1.6 Other
2 Cause
3 Diagnosis
4 Treatment
5 Epidemiology
5.1 History
6 See also
7 References
8 External links
Signs and symptoms
CREST syndrome (calcinosis and sclerodactyly)
X-rays showing calcinosis in a woman with CREST syndrome. X-ray of subtle calcifications in CREST syndrome. Calcinosis
CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). Raynaud's phenomenon
Raynaud's phenomenon is frequently the first manifestation of CREST/lcSSc, preceding other symptoms by years. Stress and cold temperature induce an exaggerated vasoconstriction of the small arteries, arterioles, and thermoregulatory vessels of the skin of the digits. Clinically this manifests as a white-blue-red transition in skin color.