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Content: Laboratory studies of the toxicity of magnolia bark and its components failed to reveal any immediate reason for concern about its use in normal doses: the LD50of magnolia bark in decoction given by injection was 6 grams per kilogram in mice and the LD50of the alkaloid magnofluorine was 45 mg/kg by injection in mice. The mean lethal dose of magnolia bark decoction given to cats by intravenous administration was 4.25 g/kg. DOSAGE
The usual dosage recommendation for magnolia bark in decoction is 3-9 grams (6, 17). It is also powdered in formulas made in pill form, in which case the daily dose ingested is typically less than 1 gram. Since prolonged boiling of the bark may reduce the content of essential oils and biphenols, the decoction requires a higher dose than the powder that is ingested in pills. PRODUCTION 
Virtually all of the magnolia bark collected for the herb market comes from cultivated supplies. Jingning County of Zhejiang Province is one of the largest production areas. Currently, China produces about 200 tons per year of magnolia bark, but there is a project underway in Jingning County to increase production to