Title: CMA - Clinical: Centromere Antibodies, IgG, Serum
Headings: Test ID: CMA
Centromere Antibodies, IgG, Serum

Test ID: CMA
Centromere Antibodies, IgG, Serum
Useful For
Suggests clinical disorders or settings where the test may be helpful
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Interpretation
Provides information to assist in interpretation of the test results
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Clinical Reference
Recommendations for in-depth reading of a clinical nature
Special Instructions
Library of PDFs including pertinent information and forms related to the test

Content: 3) Several putative epitopes associated with these autoantigens have been described. The CENP-B antigen is believed to be the primary autoantigen and is recognized by all sera that contain centromere antibodies. Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this. <1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages. Interpretation
Provides information to assist in interpretation of the test results
In various reported clinical studies, centromere antibodies occur in 50% to 96% of patients with calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis (CREST) syndrome. A positive test for centromere antibodies is strongly associated with CREST syndrome. The presence of detectable levels of centromere antibodies may antedate the appearance of diagnostic clinical features of CREST syndrome by several years.