Title: Staphylococcus saprophyticus: Which beta-lactam? - ScienceDirect
Headings: Staphylococcus saprophyticus
: Which beta-lactam?

International Journal of Infectious Diseases
Short Communication
Staphylococcus saprophyticus: Which beta-lactam?
Highlights
Abstract
Background
Methods
Results
Conclusions
Keywords
Introduction
Methods
Results
Discussion
Conflict of interest/funding
References

Content: Results
Of the S. saprophyticus isolates from urine, 59.5% were associated with a diagnosis of cystitis and 33.3% with pyelonephritis. Sixty percent of S. saprophyticus cystitis cases and 25% of pyelonephritis cases were given an inappropriate antibiotic regimen. The MICs of ceftriaxone ranged from 4 to >32 μg/ml for MSSS, and from 1.5 to 4 μg/ml for MSSA. Conclusions
Many UTIs were treated with an empirical antibiotic therapy that was ineffective for S. saprophyticus, revealing that S. saprophyticus is an aetiology that is insufficiently considered in UTI. High MICs for ceftriaxone in MSSS were observed, which raises questions about the use of this antibiotic in UTIs due to S. saprophyticus. Previous article
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Keywords
Staphylococcus saprophyticus
Beta-lactams
Minimum inhibitory concentrations
Ceftriaxone
Amoxicillin–clavulanic acid
Introduction
Staphylococcus saprophyticus is a Gram-positive coccus responsible for uncomplicated lower urinary tract infections (UTIs), mainly in young women ( Raz et al., 2005 ). The resistance of S. saprophyticus to the antibiotics commonly used in the empirical treatment of cystitis, such as cefixime and fosfomycin trometamol, complicates the treatment of patients infected with this pathogen. The objective of this study was to describe the epidemiology of UTIs associated with S. saprophyticus at the University Hospital of Angers, and to compare the susceptibility of methicillin-susceptible S. saprophyticus (MSSS) with the susceptibility of methicillin-susceptible Staphylococcus aureus (MSSA) isolates to amoxicillin–clavulanic acid and ceftriaxone. Methods
All MSSS isolated from clinical samples at the University Hospital of Angers between November 2014 and July 2016 were selected.