Title: Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years | Rheumatology | Oxford Academic
Headings: Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years
Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years
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Abstract
Topic:
Issue Section:
Methods
Results ( Table 1)
Patient demographics
Associations
Concomitant drugs
Dosing issues
Severity of pancytopenia
Discussion
References
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Content: 1
77/F
7.5 mg, 6 months oral (severe)
Moribund, sepsis
Renal impairment, low albumin
Thyroxine, folic acid, fluoxetine, frusemide, cocodamol, temazepam
Blood transfusion, folinic acid; died
2
76/M
7.5 mg, 12 months oral (not severe)
Blood monitoring
Peptic ulcer
Codydramol
Recovered
3
74/M
7.5 mg, 36 months oral (not severe)
Blood monitoring

Didronel PMO, folic acid
Recovered
4
73/F
7.5 mg, 48 months oral (not severe)
Blood monitoring sepsis, heart failure, pneumonia
Low folate, raised MCV, raised LFT
Lansoprazole, amitriptyline, celecoxib, thyroxine, oxybutinin, coproxamol
Blood transfusion, folinic acid; recovered
5
69/M
7.5 mg, 36 months oral (not severe)
Blood monitoring

Folic acid, Didronel PMO, aspirin
Recovered
6
71/M
10 mg, 48 months oral (severe)
Malaena, sepsis, bleeding gums, mucositis
Low albumin
Prednisolone, glipizide, felodipine, bisoprolol, digoxin, warfarin, lisinopril, cocodamol
Blood, platelet transfusion GCSF, folinic acid; died
7
69/M
12.5 mg, 24 months oral (not severe)
Dyspnoea, lethargy blood monitoring
Low albumin
Calcichew, aspirin, prednisolone, frusemide, alendronate, mesalazine, folinic acid
Folinic acid, AML; died
8
74/F
20 mg, 96 months oral (severe)
Sepsis, mucositis
Infected hip prosthesis low albumin
Thyroxine, prednisolone, oxytetracycline, coproxamol, fusidic acid
Folinic acid, Blood transfusion; died
9
78/M
12.5 mg, 11 months oral (severe)
Blood monitoring, epistaxis
Low folate renal impairment
Nizatidine, indoramin, diltiazem, Asasantin Retard, prochlorperazine, metoclopramide
Blood transfusion folinic acid; recovered
10
24/F
20 mg, 24 months oral (severe)
Epistaxis, PV bleed, purpura
Hepatic steatosis, anorexia, low albumin
Folic acid, loratidine, prednisolone, alendronate, coproxamol
Folinic acid; recovered
11
83/F
7.5 mg, 36 months s.c. ( not severe)
Mucositis, epistaxis, foll pamidronate
Low albumin glomerulo-nephritis
Atenolol, coamilofruse, doxazosin, folic acid, amlodipine
Folinic acid; recovered
12
84/F
10 mg, 48 months oral (not severe)
Blood monitoring
Raised MCV
Nifedipine, folic acid, meloxicam, frusemide
Recovered
13
69/M
12.5 mg, 47 months oral (not severe)
Mucositis, epistaxis sepsis
Renal impairment, low albumin, Septrin
Folic acid, Septrin, prednisolone, risedronate, atenolol, felodipine
Folinic acid, blood transfusion;