Title: Arsenic poisoning - Wikipedia
Headings: Arsenic poisoning
Arsenic poisoning
Contents
Signs and symptoms
Cancer
Causes
Drinking water
Groundwater
Food
Soil
Air
Pesticides
Copper smelting
Pathophysiology
Mechanism
Kinetics
Heat shock response
Oxidative stress
Diagnosis
Treatment
Chelation
Nutrition
History
Legislation
Challenges to implementation
Pregnancy
See also
References
Further reading
External links

Content: Arsenic is related to heart disease (hypertension-related cardiovascular disease ), cancer, stroke ( cerebrovascular diseases ), chronic lower respiratory diseases, and diabetes. Skin effects can include skin cancer in the long term, but often prior to skin cancer are different skin lesions. Other effects may include darkening of skin and thickening of skin. Chronic exposure to arsenic is related to vitamin A deficiency, which is related to heart disease and night blindness. The acute minimal lethal dose of arsenic in adults is estimated to be 70 to 200 mg or 1 mg/kg/day. Cancer
Arsenic increases the risk of cancer. Exposure is related to skin, lung, liver, and kidney cancer among others. Its comutagenic effects may be explained by interference with base and nucleotide excision repair, eventually through interaction with zinc finger structures. Dimethylarsinic acid, DMA (V), caused DNA single strand breaks resulting from inhibition of repair enzymes at levels of 5 to 100 mM in human epithelial type II cells. MMA (III) and DMA (III) were also shown to be directly genotoxic by effectuating scissions in supercoiled ΦX174 DNA.