Title: 5. Molecular mechanism of skeletal muscle contraction. Structure of skeletal muscle. The regulatory role of calcium ion – greek.doctor
Headings: 5. Molecular mechanism of skeletal muscle contraction. Structure of skeletal muscle. The regulatory role of calcium ion
5. Molecular mechanism of skeletal muscle contraction. Structure of skeletal muscle. The regulatory role of calcium ion
Table of Contents
Learning objectives
General principles of muscles
Excitation-contraction coupling
General structure of muscle cells
Structure and contraction of skeletal muscle
Structure of skeletal muscle
Mechanism of excitation
Mechanism of contraction
Termination of contraction

Content: What is the functional unit of striated muscle? What are the thin filaments anchored to? What are T-tubules? Which two proteins in the T-tubules are essential for excitation-contraction coupling, and what are their functions? Describe the mechanism of excitation of skeletal muscle
Describe the cross-bridge cycle
Describe the termination of contraction
General principles of muscles
There are three types of muscle tissue. Striated muscle, which includes skeletal and cardiac muscle, and smooth muscle. Excitation-contraction coupling
Depolarization of the motor end plate initiates a series of events which eventually cause Ca 2+ to be released from the sarcoplasmic reticulum of the muscle cell. Skeletal muscle contraction occurs when the level of Ca 2+ in the cytoplasm increases. The depolarization of the motor end plate initiates muscle contraction. For that reason, we say that excitation and contraction are coupled, a phenomenon aptly called excitation-contraction coupling, or electromechanical coupling.