Title: Staphylococcus saprophyticus: Which beta-lactam? - ScienceDirect
Headings: Staphylococcus saprophyticus
: Which beta-lactam?

International Journal of Infectious Diseases
Short Communication
Staphylococcus saprophyticus: Which beta-lactam?
Highlights
Abstract
Background
Methods
Results
Conclusions
Keywords
Introduction
Methods
Results
Discussion
Conflict of interest/funding
References

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Keywords
Staphylococcus saprophyticus
Beta-lactams
Minimum inhibitory concentrations
Ceftriaxone
Amoxicillin–clavulanic acid
Introduction
Staphylococcus saprophyticus is a Gram-positive coccus responsible for uncomplicated lower urinary tract infections (UTIs), mainly in young women ( Raz et al., 2005 ). The resistance of S. saprophyticus to the antibiotics commonly used in the empirical treatment of cystitis, such as cefixime and fosfomycin trometamol, complicates the treatment of patients infected with this pathogen. The objective of this study was to describe the epidemiology of UTIs associated with S. saprophyticus at the University Hospital of Angers, and to compare the susceptibility of methicillin-susceptible S. saprophyticus (MSSS) with the susceptibility of methicillin-susceptible Staphylococcus aureus (MSSA) isolates to amoxicillin–clavulanic acid and ceftriaxone. Methods
All MSSS isolated from clinical samples at the University Hospital of Angers between November 2014 and July 2016 were selected. These strains were categorized as susceptible to oxacillin by the Vitek 2 System (bioMérieux, Marcy l’Etoile, France) and by the disc diffusion method (cefoxitin diameter ≥22 mm according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommendations). Eighty-five S. saprophyticus strains met these criteria. For every S. saprophyticus isolate, data on the type of infection, direct examination of the urine sample, the clinical ward, and the empirical antibiotic therapy used were recorded. In parallel, 17 MSSA isolates were randomly selected based on the same criteria. The minimum inhibitory concentrations (MICs) of amoxicillin–clavulanic acid and ceftriaxone were determined using Etest strips (bioMérieux) and broth microdilution (Sensititre;