Title: Type 2 diabetes in adolescents and young adults - The Lancet Diabetes & Endocrinology
Headings: Type 2 diabetes in adolescents and young adults
Type 2 diabetes in adolescents and young adults
Summary
Introduction
Epidemiology
Pathophysiology
Decline in β-cell function
Obesity-induced mechanisms
Key drivers for the development of type 2 diabetes in young people
Early life determinants
Diet and obesity
Physical activity
Socioeconomic factors
Family history
Female sex and polycystic ovarian syndrome
Non-alcoholic fatty liver disease
Clinical characteristics
Complications
Microvascular complications
Macrovascular complications
Other complications
Treatment
Lifestyle changes
Pharmacological and surgical approaches
Table 2 Key studies showing the effectiveness of interventions to treat young-onset type 2 diabetes
Societal effects of type 2 diabetes in young people
Summary and future research directions
Search strategy and selection criteria
Contributors
Declaration of interests
References
Article Info
Publication History
Identification
Copyright
ScienceDirect
Figures
Tables

Content: Epidemiology
Type 2 diabetes is increasingly diagnosed in children, adolescents, and young adults. Prevalence estimates suggest a 31% increase in type 2 diabetes among people aged 10–19 years in the USA between 2001 and 2009, accounting for a prevalence of 0·48 per 1000 in this age group in 2009. 5
Dabelea D
Mayer-Davis EJ
Saydah S
et al. for the SEARCH for Diabetes in Youth Study
Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA. 2014; 311: 1778-1786
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Recent data from the SEARCH study (a multicentre, observational study in the USA involving 11 245 young people with type 1 diabetes [0–19 years] and 2846 with type 2 diabetes [10–19 years]),
6
Mayer-Davis EJ
Lawrence JM
Dabelea D
et al. for the SEARCH for Diabetes in Youth Study
Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med.