Title: T-Tubule - an overview | ScienceDirect Topics
Headings: T-Tubule
T-Tubule
Ion Channel Trafficking
T-Tubules
Skeletal Muscle
T-tubules Are Surface Invaginations; the SR Is an Internal Membrane System
Structure and Function of Calcium Release Channels
2 T Tubules and CRUs Revert to More Primitive Forms Under Pathological Conditions
Muscles
Coupling Action Potentials to Contraction
The Cellular Basis of Cardiac Contractility
The SR Releases Stored Ca 2+ to Activate Contraction
Disorders of Muscle Excitability
Calcium couples muscle membrane excitation to filament contraction
Muscle physiology
Excitation–contraction coupling
EXERCISE | Muscle
Voltage-dependent Sarcoplasmic Reticulum Ca 2+ Release

Content: 71 Integrity of NCX/NKA/InsP3 complex is critical in removing calcium from the clefts between T-tubule surface and SR membrane, facilitating calcium decline during relaxation. Therefore, intracellular calcium equilibrium can be achieved by balancing calcium entry through LTCC clustered at BIN1-membrane and calcium removal by NCX anchored at ankyrin B-induced membrane. View chapter Purchase book
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URL: https://www.sciencedirect.com/science/article/pii/B9780128020029000029
Skeletal Muscle
Clara Franzini-Armstrong, Andrew G. Engel, in Muscle, 2012
T-tubules Are Surface Invaginations; the SR Is an Internal Membrane System
T-tubules have a random, mostly longitudinal, disposition between the myofibrils during their initial formation but even at this stage they immediately form junctions with SR elements. The mature position of T-tubules within planes perpendicular to the fiber long axis (Figure 53.1A,B) is acquired gradually during the coordinated differentiation of myofibrils and membrane system. This reorientation takes up to a month in chick and mouse muscles and the association of the whole triad assembly with the appropriate myofibril location drives it, perhaps via ankyrin and the giant protein obscurin. However, longitudinal remnants of the T network are still present in the adult. The T-tubules actually carry an action potential in some but perhaps not all fibers, but a depolarization of the tubules rather than the action potential is a triggering event in EC coupling (7). The initial description of the SR (2) correctly identified this organelle as a differentiated form of the ubiquitous endoplasmic reticulum (ER), characterized by its abundance and its precise positioning and relationship to the myofibrils ( Figure 53.2 ).