Title: Sulfonamide (medicine) - Wikipedia
Headings: Sulfonamide (medicine)
Sulfonamide (medicine)
Contents
Function
History
Preparation
Varieties
Side-effects
See also
References
External links

Content: The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Contents
1 Function
2 History
3 Preparation
4 Varieties
5 Side-effects
6 See also
7 References
8 External links
Function
Main article: Dihydropteroate synthase inhibitor
In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase (DHPS), an enzyme involved in folate synthesis. Sulfonamides are therefore bacteriostatic and inhibit growth and multiplication of bacteria, but do not kill them.