Title: Sulfadimethoxine - Wikipedia
Headings: Sulfadimethoxine
Sulfadimethoxine
Contents
Mechanism
With ormetoprim
Pharmacokinetics
Usage
Notes

Content: Dogs are the exception – since they are unable acetylate sulfanamides, they excrete sulfadimethoxine mostly unchanged in the urine (their inability to transform sulfadimethoxine also makes them more susceptible to negative side effects). Sulfadimethoxine has a relatively high solubility at the pH normally occurring in the kidneys, and is easily reabsorbed into the renal tubules, adding to its long half-life. The use of sulfadimethoxine raises concerns that it will precipitate in the kidneys, leading to crystalluria. Though crystallization is not actually a common occurrence in veterinary medicine, it can be avoided entirely by adding a diaminopyrimidine such as ormetoprim. Having the animal stay well-hydrated also is advised. Usage
Sulfadimethoxine is the only FDA-approved drug for treating intestinal coccidioisis in cats and dogs. It is also used for: Treating skin and soft-tissue infections in dogs caused by Staphylococcus aureus or E. coli
Treating cattle for bovine respiratory disease complex ("shipping fever complex"), necrotic pododermatitis (foot rot), pneumonia when caused by Pasteurella, and calf diphtheria caused by Fusobacterium necrophorum
When combined with ormetoprim: Treating soft tissue infections, skin infections, urinary tract infections, and intesintal coccidia infections in dogs
Prevention of fowl cholera and coccidioisis by Eimeria in poultry
Treating salmon and trout for furunculosis
It is also one of the only sulfonamides allowed for treating lactating dairy cattle (the others being sulfabromethazine and sulfathoxypyridazine). Notes
^ a b "SulfaMed (sulfadimethoxine) Injection 40% for Animal Use".