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Content: We spoke to our Assistant Director of Nursing, Andrea Oster, for her tips and tricks for avoiding arm soreness post-shot: 1.) Relax your arm when getting the shot. " It can be hard to do when you're nervous, but do not tense up," Andrea says. While you're sitting, lay your hand flat on your upper leg and relax your shoulder, letting your arm hang until the nurse administers the shot. 2.) Take ibuprofen or Tylenol. A lot of the pain comes from inflammation. Taking a painkiller will do wonders in reducing swelling and assisting with the discomfort. 3.)