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Content: There are many groups of drugs that contain sulfa. Examples include antibiotics (sulfamethoxazole/trimethoprim), diuretics for high-blood  pressure  (hydrochlorothiazide,  furosemide), sulfonylureas for reducing blood sugar in diabetes mellitus (glyburide),  and  dapsone  for  leprosy  (18). Other  drugs containing sulfa include burn creams and eye drops. Drugs containing sulfa were one of the earliest drugs used against bacterial  infections. Antibiotic  derivatives  of  sulfa  drugs include  septrin,  gantanol,  and  bactrim. Bactrim  is  the most common drug used in patients with MRSA diabetic foot  infection  (19). Today,  it  is  a  commonly  prescribed prophylactic  drug  for  patients  living  with  HIV/AIDS. These patients should be monitored because a retrospective cohort study showed that sulfamethoxazole/trimethoprim could cause reversible hyperkalemia in HIV patients (20). Trimethoprim works by inhibiting dihydrofolate reductase while  sulfamethoxazole  inhibits  dihydropteroate  synthase (21). Together they inhibit the production of folic acid in bacterial cells thereby making it bactericidal.