Title: Centromere Antibodies, IgG, Serum - Mayo Clinic Laboratories | Neurology Catalog
Headings: Test ID:
CMA
Centromere Antibodies, IgG, Serum

Test ID: CMA Centromere Antibodies, IgG, Serum
Reporting Name
Useful For
Clinical Information
Interpretation
Testing Algorithm
Analytic Time
Day (s) and Time (s) Performed
Clinical Reference
Method Name
Specimen Type
Specimen Required
Container/Tube:
Specimen Minimum Volume
Specimen Stability Information
Special Instructions
Reference Values
Test Classification
CPT Code Information
LOINC Code Information

Content: 2) In subsequent studies, centromere antibodies were found to react with several centromere proteins of 18 kDa, 80 kDa, and 140 kDa named as CENP-A, CENP-B, and CENP-C, respectively. ( 3) Several putative epitopes associated with these autoantigens have been described. The CENP-B antigen is believed to be the primary autoantigen and is recognized by all sera that contain centromere antibodies. Interpretation
In various reported clinical studies, centromere antibodies occur in 50% to 96% of patients with calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis (CREST) syndrome. A positive test for centromere antibodies is strongly associated with CREST syndrome. The presence of detectable levels of centromere antibodies may antedate the appearance of diagnostic clinical features of CREST syndrome by several years. Testing Algorithm
See Connective Tissue Disease Cascade (CTDC) in Special Instructions. Analytic Time
Same day/1 day
Day (s) and Time (s) Performed
Monday through Saturday; 4 p.m.
Clinical Reference
1. White B: