Title: Magnolia Bark Extract: Benefits, Side Effects & Dosage
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Content: Gingivitis
Magnolia extract may be effective at combating gingivitis and bad breath. Many separate studies have verified that toothpaste and gum that contains magnolia extract reduces the amount of gingivitis on the gums and kills bacteria that cause bad breath ( x, x ). Studies show that both honokiol and magnolol may have potent antimicrobial effects and have the potential to treat periodontal pathogens ( x ). Anxiety & Depression
Magnolia extract may also have connection with anxiety. Researchers believe that honokiol acts on GABA receptors in the brain in a similar manner to benzodiazepines and Z-drugs ( x ). However, honokiol has fewer motor and cognitive side effects than traditional anxiety medications, such as Xanax and Klonopin. Thus, honokiol is more selective in the receptors it binds to, which enables it to produce a similar anxiolytic effect with fewer detrimental side effects. One particular study found that an active dose as small as 0.2 mg/kg can possibly significantly increase exploratory behavior and decrease anxiety-related behavior in animal models. The same study also found that honokiol is effective at combating the anxiety-producing effects of large doses of caffeine ( x ). Additionally, studies show that a blend of honokiol and magnolol may reduce corticosterone concentration in the brain, which is associated with symptoms of depression ( x ).